LOCUS       DBMVGT010000001       119091 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.001, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000001 DBMVGT010000000
VERSION     DBMVGT010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 119091)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 119091)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..119091
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.001"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..324
                     /locus_tag="AC0DU4_000001"
     CDS             <1..324
                     /locus_tag="AC0DU4_000001"
                     /EC_number="5.4.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006703946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004619 - phosphoglycerate mutase activity
                     [Evidence IEA];
                     GO_function: GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="2,3-bisphosphoglycerate-dependent
                     phosphoglycerate mutase"
                     /protein_id="HIN4236055.1"
                     /translation="MDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERALPFWEDKI
                     APALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDEKLNVVSE
                     YYLGK"
     gene            377..2788
                     /locus_tag="AC0DU4_000002"
     CDS             377..2788
                     /locus_tag="AC0DU4_000002"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000620712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="HIN4236056.1"
                     /translation="MIRNKKQDYVLAYKQPASTTYMGWEEEALPIGNGSLGAKVFGRI
                     GAERIQFNEKSLWSGGPLPDSSDYQGGNLQDQYVFLAEIRQALEKRDYNLAKELAEQH
                     LIGPKTSQYGTYLSFGDIHIEFSQQGTTLSQVTDYQRQLNISKALVTTSYVYKGTRFE
                     REAFASFPDDLLVQRFTKEGAETLDFTIELSLTCDLASDEKYEQEKSDYKECKLDITD
                     SHILMKGRVKDNDLRFASYLAWETDGDIRVWSDRVQISGASYANLFLAAKTDFAQNPA
                     SNYRKKLDLEQQVIDLVDTAKEKGYTQLKSRHIEDYQALFQRVQLDLEADVDASTTDD
                     LLKNYKPQEGQALEELFFQYGRYLLISSSRDCPDALPANLQGVWNAVDNPPWNSDYHL
                     NVNLQMNYWPAYVTNLLEAVFPVINYVDDLRVYGRLAAVKYAGIVSQKGEENGWLVHT
                     QATPFGWTAPGWDYYWGWSPAANAWMMQTVYEAYSFYRDQDYLREKIYPMLRETVRFW
                     NAFLHKDQQAQRWVSSPSYSPEHGPISIGNTYDQSLIWQLFHDFIQAAQELGLDEDLL
                     TEVKEKSDLLNPLQITQSGRIREWYEEEEQYFQNEKVEAQHRHASHLVGLYPGNLFSY
                     KGQEYIEAARASLNDRGDGGTGWSKANKINLWARLGDGNRAHKLLAEQLKTSTLPNLW
                     CSHPPFQIDGNFGATSGMAEMLLQSHAAYLVPLAALPDAWSTGSVSGLMARGHFEVSM
                     SWEDKKLLQLTILSRSGGDLRVSYPDIEKSVIKMNQEKIKAKCMGKDCISVATAEGDL
                     VQFYF"
     gene            3038..3739
                     /locus_tag="AC0DU4_000003"
     CDS             3038..3739
                     /locus_tag="AC0DU4_000003"
                     /EC_number="7.6.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236057.1"
                     /translation="MAYIEMKHCYKRYQVGDTEIVANRDVNFEIEKGELVIILGASGA
                     GKSTVLNLLGGMDTNDEGEIWIDGVNIADYSSHQRTNYRRNDVGFVFQFYNLVSNLTA
                     KENVELASEIVTDALNPDQVLTDVGLAHRLNNFPAQLSGGEQQRVSIARAVAKNPKIL
                     LCDEPTGALDYQTGKQVLKILQDMSRQKGATVIIVTHNGALAPIADRVIHMHDASVKD
                     VVLNQHPQDIDSLEY"
     gene            3741..6449
                     /locus_tag="AC0DU4_000004"
     CDS             3741..6449
                     /locus_tag="AC0DU4_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HIN4236058.1"
                     /translation="MIKRKTYWKDLIQSFTGSKGCFLSILILMMLGSLALVGLKVTSP
                     NMEATANAYLTTAQTLDLAVMSNYGLDQADQEELKQTEGAEVEFGYLTDVTMDNGQDA
                     IRLYSKPERISTFQLRKGRLPQSDKEIALATHLQGQYSVGQEISFKEKEEGHSSLKDH
                     TYTITGFVDSAEILSQRDMGYAGSGSGTLTAYGVILPSQFDQKVYNIARLKYQDLAGL
                     NVFSSAYEEKSKQHQEELEQILSDNGKVRLQLLKKEGQESLDKGQETLDKAQTNLQEG
                     KRRLAAAQARIQAQESQLALFPQVQREQASAQLTQAKQELGKEEDKLKQAEQNLAQEK
                     EKLEKHQQVLDDLAEPRYQVYNRQTMPGGQGYLMYSNASSSIRAVGNIFPVVLYAVAA
                     MVTFTTMTRFVDEERTHAGIFKALGYRSKDIIAKFLLYGLVAGTVGTALGSILGHYLL
                     ASVISSVITKGMVVGETQIQFYWTYSLLAFVLSLLASVLPAYLVAWRELHDEAAQLLL
                     PKPPVKGAKILLERIGFIWRRLSFTHKVTARNIFRYKQRMLMTIFGVAGSVALLFAGL
                     GIQSSVAGVPSKQFQQIQQYQMLVSENPSATNQDKVELAEVLKGQEILAYQKIYSKAL
                     YKDFKGKAGLQNITLMMIEKEDLTPFIHLQHHQQELTLKDGIVITAKLAQLAGVKVGQ
                     TLEIEGKELKVAAITENYVGHFIYMSQASYEQLYGQLPQANTYLVSLRDTSATSIESQ
                     AGLLMNQSAVSSVVQNASAIRLFDSIASSLNQTMTILVIVSVLLAIVILYNLTNINVA
                     ERIRELSTIKVLGFHNNEVTLYIYRETIVLSLVGIVLGLIAGFYLHQFLIQMISPATI
                     LFYPQVGWEVYVIPVAAVSIILTLLGFFVNYYLRKVDMLEALKSVE"
     gene            complement(6545..7036)
                     /gene="tpx"
                     /locus_tag="AC0DU4_000005"
     CDS             complement(6545..7036)
                     /gene="tpx"
                     /locus_tag="AC0DU4_000005"
                     /EC_number="1.11.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008379 - thioredoxin peroxidase activity
                     [Evidence IEA];
                     GO_function: GO:0016684 - oxidoreductase activity, acting
                     on peroxide as acceptor [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiol peroxidase"
                     /protein_id="HIN4236059.1"
                     /translation="MVTFLGNPVSFTGKQLQVGDKALDFSLTTTDLSKKSLADFDGKK
                     KVLSVVPSIDTGICSTQTRRFNEELAGLDNTVVLTVSMDLPFAQKRWCGAEGLDNAIM
                     LSDYFDHSFGHDYALLINEWHLLARAVFVLDTDNTIRYVEYVDNINSEPNFEAAIAAA
                     KAL"
     gene            complement(7159..8088)
                     /gene="psaA"
                     /locus_tag="AC0DU4_000006"
     CDS             complement(7159..8088)
                     /gene="psaA"
                     /locus_tag="AC0DU4_000006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000733059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter substrate-binding
                     lipoprotein/adhesin PsaA"
                     /protein_id="HIN4236060.1"
                     /translation="MKKLGTLLVLFLSAIILVACASGKKATTSGQKLKVVATNSIIAD
                     ITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTK
                     LVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSA
                     KDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVP
                     SAYIWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQ
                     IFTDSIAEQGKEGDSYYSMMKYNLDKIAEGLAK"
     gene            complement(8120..8968)
                     /locus_tag="AC0DU4_000007"
     CDS             complement(8120..8968)
                     /locus_tag="AC0DU4_000007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000559784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease subunit"
                     /protein_id="HIN4236061.1"
                     /translation="MIAEFIDGLQKFHFLQNALITAIVVGIVAGAVGCFIILRGMSLM
                     GDAISHAVLPGVALSFILGLDFFIGAIVFGLLAAIIITYIKGNSIIKSDTAIGITFSS
                     FLALGIILIGVAKSSTDLFHILFGNILAVQDTDMFITMGVGAAILLLIWIFFKQLLIT
                     SFDELLAKAMGMPVNFYHYLLMVLLTLVSVTAMQSVGTILIVAMLITPAATAYLYANS
                     LKSMIFLSSTFGATASVLGLFIGYSFNVAAGSSIVLTAASFFLISFFIAPKQRYLKLK
                     NKHLLK"
     gene            complement(8965..9687)
                     /locus_tag="AC0DU4_000008"
     CDS             complement(8965..9687)
                     /locus_tag="AC0DU4_000008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HIN4236062.1"
                     /translation="MIRIENLSVSYKETLALKDISLVLHGPTITGIIGPNGAGKSTLL
                     KGMLGIIPHQGQAFLDDKEVKKSLHRIAYVEQKINIDYNFPIKVKECVSLGLFPSIPL
                     FRSLKAKHWKKVQEALEIVGLADYAERQISQLSGGQFQRVLIARCLVQEADYILLDEP
                     FAGIDSVSEEIIMNTLRDLKKAGKTVLIVHHDLSKIPHYFDQVLLVNREVIAFGPTKE
                     TFTETNLKEAYGNQLFFNGGDL"
     gene            9978..11870
                     /gene="pepO"
                     /locus_tag="AC0DU4_000009"
     CDS             9978..11870
                     /gene="pepO"
                     /locus_tag="AC0DU4_000009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase PepO"
                     /protein_id="HIN4236063.1"
                     /translation="MTRYQDDFYDAINGEWQQTAEIPADKSQTGGFVDLDQEIEDLML
                     ATTDKWLAGEEVPEDAILENFVKYHRLVRDFDKREADGITPVLPLLKEFQELETFADF
                     TAKLAEFELAGKPNFLPFGVSPDFMDARINVLWASAPSTILPDTTYYAEEHPQREELL
                     TLWKESSANLLKAYDFSDEEIEDLLEKRLELDRRVATVVLSNEESSEYAKLYHPYSYE
                     DFKKFAPALPLDDFFKAVIGQLPDKVIVDEERFWQAAEQFYSEEAWSLLKATLILSVV
                     NLSTSYLTEDIRVLSGAYSRALSGVPEAKDKVKAAYHLAQEPFKQALGLWYAREKFSP
                     EAKADVEKKVATMIDVYKERLLKNDWLTPETCKQAIVKLNVIKPYIGYPEELPARYKD
                     KVVNETASLFENALAFARVEIKHSWSKWNQPVDYKEWGMPAHMVNAYYNPQKNLIVFP
                     AAILQAPFYDLHQSSSANYGGIGAVIAHEISHAFDTNGASFDENGSLKDWWTESDYAA
                     FKEKTQKVIDQFDGQDSYGATINGKLTVSENVADLGGIAAALEAAKREADFSAEEFFY
                     NFGRIWRMKGRPEFMKLLASVDVHAPAKLRVNVQVPNFDDFFTTYDVKEGDGMWRSPE
                     ERVIIW"
     gene            complement(11993..12622)
                     /locus_tag="AC0DU4_000010"
     CDS             complement(11993..12622)
                     /locus_tag="AC0DU4_000010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HIN4236064.1"
                     /translation="MKIHKTVNPVAYENTYYLEGEKHLIVVDPGSHWEAIRQTIEKIN
                     KPICAILLTHAHYDHIMSLDLVRETFGNPPVYIAESEASWLYTPVDNLSGLPRHDDMA
                     DVVTKPAEHTFVFHEEYQLEEFRFKVLPTPGHSIGGVSLVFPDAHLVLTGDALFRETI
                     GRTDLPTGSMEQLLHSIQTQLFTLPNYDVYPGHGPATTIAHEKAFNPFF"
     gene            13618..15840
                     /locus_tag="AC0DU4_000011"
     CDS             13618..15840
                     /locus_tag="AC0DU4_000011"
                     /EC_number="2.7.6.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019316080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008728 - GTP diphosphokinase activity
                     [Evidence IEA];
                     GO_function: GO:0008893 - guanosine-3',5'-bis(diphosphate)
                     3'-diphosphatase activity [Evidence IEA];
                     GO_process: GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RelA/SpoT family protein"
                     /protein_id="HIN4236065.1"
                     /translation="MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYR
                     KSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRVIV
                     DGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQ
                     ERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALV
                     DEVVTKLEEYTTERHLKGKIYGRPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQS
                     DVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEV
                     AEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAE
                     EIYVFTPDGAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVE
                     IIANPNSFGPSRDWLNMVKTSKARNKIRQFFKNQDKELSVNKGREMLMDQFQENGYVA
                     NKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEERAKAKAE
                     AEELVKGGEVKVENKETLKVKYEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGR
                     GVAIHRVDCMNLRAQENYEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQ
                     VLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTTVVDKIKSVPEVYSVKRTNG
                     "
     gene            15870..16313
                     /gene="dtd"
                     /locus_tag="AC0DU4_000012"
     CDS             15870..16313
                     /gene="dtd"
                     /locus_tag="AC0DU4_000012"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004045 - peptidyl-tRNA hydrolase activity
                     [Evidence IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="HIN4236066.1"
                     /translation="MKIIIQRVKKAQVSIEGQIQGKINQGLLLLVGVGPEDQEEDLDY
                     AVRKLVNMRIFSDAEGKMNLSVKDIEGEILSISQFTLFADTKKGNRPAFTGVAKPDMA
                     SDFYDAFNQKLAQEVPVQTGIFGANMQVELVNNGPVTIILDTKKR"
     gene            complement(16352..16767)
                     /locus_tag="AC0DU4_000013"
                     /pseudo
     CDS             complement(16352..16767)
                     /locus_tag="AC0DU4_000013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000720030.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            17105..17488
                     /locus_tag="AC0DU4_000014"
     CDS             17105..17488
                     /locus_tag="AC0DU4_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000514168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236067.1"
                     /translation="MQKENVRMRLASESRQILDKLKDDVYNKLGYEVSYSSIVSQAVR
                     EYVPKKERIDWIKLKETAIPFSSLKQSNNWEYQTSLMLEEDVLILLSELQNFFLDVFQ
                     AKRIHRAFCVRLCLKAQFLLSNNDS"
     gene            17669..17968
                     /locus_tag="AC0DU4_000015"
     CDS             17669..17968
                     /locus_tag="AC0DU4_000015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001081475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236068.1"
                     /translation="MNRDVLEFLRTETAEKISLYISEANRLEGDVTLLAPSSQDLEDI
                     KNAMLSNSNLGLKVARLDVMKKIAYASTRNHYLTGATIFGDISKGTYNCDPKSYV"
     gene            complement(18063..18500)
                     /locus_tag="AC0DU4_000016"
     CDS             complement(18063..18500)
                     /locus_tag="AC0DU4_000016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236069.1"
                     /translation="MKKLYRIHFIAIAVIDLLLFAFFITRLETSFEWLLLSGLIFFLA
                     QGLLLFLLVVRLKHQFAEIYPQINKKIRFYYLGVLTIDFLFFVLLAFISSQRFSSLMP
                     IITACHSTFYYMTADYLGENYPDFYDKHISNTYTILSISSFLV"
     gene            complement(18602..19267)
                     /locus_tag="AC0DU4_000017"
     CDS             complement(18602..19267)
                     /locus_tag="AC0DU4_000017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000260183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0034257 - nicotinamide riboside
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0034258 - nicotinamide riboside transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide mononucleotide transporter"
                     /protein_id="HIN4236070.1"
                     /translation="MAIASGYLNSRLDKFVDWGPWTALVPFGLISVTNVGISMLSTRF
                     TGKLSKWGNYFGIVNTILSGAIDYILGNKAAIITYPVTFLIYTFAIKKWKASQEGRPN
                     QMSQKQVKLAAIIISIIAFLFAFVTNYIGYEGKMNLLAYVTTIAFALSLIANALNALK
                     LTTQWGFWLIYNFVQLTKAGIQGNFANIGKYIFYILNAIGALFVWNDEEVRYIEGNSN
                     KEY"
     gene            complement(19455..20105)
                     /locus_tag="AC0DU4_000018"
     CDS             complement(19455..20105)
                     /locus_tag="AC0DU4_000018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000188500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent transcriptional regulator"
                     /protein_id="HIN4236071.1"
                     /translation="MTPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKR
                     MKSENLILKDKECGYLLTDLGLKLVSELYRKHRLIEVFLVHHLDYTSDQIHEEAEVLE
                     HTVSDLFVERLDKLLGFPKTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHD
                     SFDILHYLDKHSLHIGDQLQVKQFDGFSNTFTILSNDEDLQVNMDIAKQLYVEKIN"
     gene            20217..21059
                     /locus_tag="AC0DU4_000019"
     CDS             20217..21059
                     /locus_tag="AC0DU4_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HIN4236072.1"
                     /translation="MTKIALLSDIHGNTTALEAVLADAQQLGVDEYWLLGDILMPGTG
                     RRRILDLLDQLPITARVLGNWEDSLWHGVRKELDSTRPSQRYLLRQCQYVLEEISLEE
                     IEVLHNQPLQIHRQFGDLTVGISHHLPDKNWGRELIHTGKQENFDRLVTHPPCDIAVY
                     GHIHQQLLRHGTGGQLIVNPGSIGQPFFLDAQLRKDLRAQYMILEFDGKGLVDMDFRR
                     VDYDVAAELQLAKDLRLPYFEVYYESLVNGIHHTHHQEFLRELAQKEGCDRELDDWLK
                     SGND"
     gene            21135..21572
                     /locus_tag="AC0DU4_000020"
     CDS             21135..21572
                     /locus_tag="AC0DU4_000020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HIN4236073.1"
                     /translation="MQIPSRFTIATHMLIIIALEGKESKVTSDFLAASVGVNPVIIRK
                     ILSQLKKAELISVARGTGGTEIVKDLKDISLLDVYQAVECLGKTGQLFSFHDNPNPNC
                     PVGAHIHDVLDQKLERIQLTMEAELGQTSLEKVVADAESQMKD"
     gene            21641..21943
                     /locus_tag="AC0DU4_000021"
     CDS             21641..21943
                     /locus_tag="AC0DU4_000021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000281600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236074.1"
                     /translation="MYLVIEIVLAFIVSFWKDNRSLWNPVLFLLSLISSYFYLSYLFY
                     KNGYENVQLAFYVFTFVLLPFLLFLSGIFLIYNGVILLKREGRSKPHYLSMLFDFY"
     gene            complement(22034..23107)
                     /locus_tag="AC0DU4_000022"
     CDS             complement(22034..23107)
                     /locus_tag="AC0DU4_000022"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2974 domain-containing protein"
                     /protein_id="HIN4236075.1"
                     /translation="MANIFDYLKDVAYDSYYDLPLNELDILTLIEITYLSFDNLVSTL
                     PQRLLDLAPQVPREPTMLTSKNRLQLLDELAQHKRFKNCKLSHFINDIDPELQKQFAA
                     MTYRVSLDTYLIVFRGTDDSIIGWKEDFHLTYMKEIPAQKHALRYLKNFFAHHPKQKV
                     ILAGHSKGGNLAIYAASQIEQSLQNQITAVYTFDAPGLHQELTQTAGYQRIMDRSKIF
                     IPQGSIIGMMLEIPAHQIIVQSTALGGIAQHDTFSWQIEDKHFVQLDKTNSDSRQVDT
                     TFKEWVATVPDEELQLYFDLFFGTILDAGISSINDLASLKALEYIHHLFVQAQSLTPE
                     ERETLGRLTQLLIDTRYHAWKNR"
     gene            23263..23940
                     /locus_tag="AC0DU4_000023"
     CDS             23263..23940
                     /locus_tag="AC0DU4_000023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HIN4236076.1"
                     /translation="MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQS
                     EPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSSRDQAMDIVMAINMGADDFVTKP
                     FDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
                     RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGI
                     GYGLKHA"
     gene            23933..24907
                     /locus_tag="AC0DU4_000024"
     CDS             23933..24907
                     /locus_tag="AC0DU4_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HIN4236077.1"
                     /translation="MLDWKQFFLAYLRSRSRLFIYLLFLAFLVLLFQFLFASLGIYFL
                     YFFFLCCFVTILFFTWDILVETQVYRQELLYGEREAKSPLEIALAEKLEAREMELYQQ
                     RSKAERKLTDLLDYYTLWVHQIKTPIAASQLLVAEVVDRQLKQQLEQEIFKIDSYTNL
                     VLQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLHDLDKEIVTDKKW
                     LLVVIEQIISNSLKYTKEGGLEIYMDDQELCIKDTGIGIKNSDVLRVFERGFSGYNGR
                     LTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTTVRIQFAQVNLVLE"
     gene            complement(24956..26899)
                     /gene="thrS"
                     /locus_tag="AC0DU4_000025"
     CDS             complement(24956..26899)
                     /gene="thrS"
                     /locus_tag="AC0DU4_000025"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000608363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004829 - threonine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006435 - threonyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HIN4236078.1"
                     /translation="MINITFPDGAVREFESGVTTFEIAQSISNSLAKKALAGKFNGKL
                     IDTTRAITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGF
                     YYDTDNIAGQISNEDLPRIEEEMQKIVKENFPSIREEVTKDEAREIFKNDPYKLELIE
                     EHSEDEGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLHVAGAYWRGNSDNAMMQRIY
                     GTAWFDKKDLKNYLQMREEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRE
                     LERYIVNKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPTMDMGDGEEFVLRPM
                     NCPHHIQVFKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHLFVTP
                     EQIQEEFQRALQLIIDVYEDFNLTDYRFRLSLRDPQDTHKYFDNDEMWENAQTMLRAA
                     LDEMGVDYFEAEGEAAFYGPKLDIQIKTALGKEETLSTIQLDFLLPERFDLKYIGADG
                     EDHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVNYAWEVA
                     KKLRDRGVRADVDERNEKMQFKIRASQTSKIPYQLIVGDKEMEDETVNVRRYGQKETQ
                     TVSVDNFVQAILADIANKSRVEK"
     gene            complement(26957..27280)
                     /locus_tag="AC0DU4_000026"
     CDS             complement(26957..27280)
                     /locus_tag="AC0DU4_000026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000422771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like protein"
                     /protein_id="HIN4236079.1"
                     /translation="MELQELVEHSWAIRQAYHELEVKHHDSKWTVEEDLLALSNDIGN
                     FQRLVMTKQGRYYDETPYTLEQKLSENIWWLLELSQRLDIDILTEMENFLSDKEKQLN
                     VRTWK"
     gene            complement(27537..27904)
                     /locus_tag="AC0DU4_000027"
                     /pseudo
     CDS             complement(27537..27904)
                     /locus_tag="AC0DU4_000027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397621.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            28145..28775
                     /locus_tag="AC0DU4_000028"
                     /pseudo
     CDS             28145..28775
                     /locus_tag="AC0DU4_000028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398308.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0070403 - NAD+ binding [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-dependent oxidoreductase"
     gene            28916..29185
                     /gene="rpsO"
                     /locus_tag="AC0DU4_000029"
     CDS             28916..29185
                     /gene="rpsO"
                     /locus_tag="AC0DU4_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HIN4236080.1"
                     /translation="MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIK
                     QHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR"
     gene            30001..30615
                     /locus_tag="AC0DU4_000030"
     CDS             30001..30615
                     /locus_tag="AC0DU4_000030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000531723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CadD family cadmium resistance transporter"
                     /protein_id="HIN4236081.1"
                     /translation="MGQTIISAIGVYISTSIDYLIILIILFAQLSQNKQKWHIYAGQY
                     LGTGLLVGASLVAAYVVNFVPEEWMVGLLGLIPIYLGIRFAIVGEDAEEEEEEIIERL
                     EQSKANQLFWTVTLLTIASGGDNLGIYIPYFASLDWSQTLVALLVFVIGIIIFCEISR
                     VLSSIPLIFETIEKYERIIVPLVFILLGLYIMYENGTIETFLIV"
     gene            complement(30908..31657)
                     /locus_tag="AC0DU4_000031"
     CDS             complement(30908..31657)
                     /locus_tag="AC0DU4_000031"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="HIN4236082.1"
                     /translation="MFYTYLRGLVVLLLWSINGNAHYHNTDKIPNQDENYILVAPHRT
                     WWDPVYMAFATKPKQFIFMAKKELFTNRIFGWWIRMCGAFPIDRENPSASAIKYPINV
                     LKKSDRSLIMFPSGSRHSNDVKGGAALIAKMAKVRIMPVTYTGPMILKGLISRERVDM
                     NFGNPIDISDIKKMNDEGIETVANRIQTEFQRLDEETKQWHNDKKPNPLWWFIRIPAL
                     ILAIILAILTIIFSFIASFIWNPDKKREELA"
     gene            31790..34126
                     /locus_tag="AC0DU4_000032"
     CDS             31790..34126
                     /locus_tag="AC0DU4_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015662 - P-type ion transporter activity
                     [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0019829 - ATPase-coupled monoatomic cation
                     transmembrane transporter activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HIN4236083.1"
                     /translation="MDKNKIMGLTQREVKERQAEGLVNDFTASASTSTWQIVKRNVFT
                     LFNALNFAIALALAFVQAWSNLVFFAVICFNAFSGIVTELRAKHMVDKLNLMTKEKVK
                     TIRDGQEVALNPEELVLGDVIRLSAGEQIPSDALVLEGFAEVNEAMLTGESDLVQKEV
                     DGLLLSGSFLASGSVLSQVHHVGADNYAAKLMLEAKTVKPINSRIMKSLDKLAGFTGK
                     IIIPFGLALLLEALLLKGLPLKSSVVNSSTALLGMLPKGIALLTITSLLTAVIKLGLK
                     KVLVQEMYSVETLARVDMLCLDKTGTITQGKMQVEAVLPLTETYGEEAIASILTSYMA
                     HSEDKNPTAQAIRQRFVGDVAYPMISNLPFSSDRKWGAMELEGLGTVFLGAPEMLLDS
                     EVPEAREALERGSRVLVLALSQEKLDHHKPQKPSDIQALALLEILDPIREGAAETLDY
                     LRSQEVGLKIISGDNPVTVSSIAQKAGFADYHSYVDCSKITDEELMAMAEETAIFGRV
                     SPHQKKLIIQTLKKAGHTTAMTGDGVNDILALREADCSIVMAEGDPATRQIANLVLLN
                     SDFNDVPEILFEGRRVVNNIAHIAPIFLIKTIYSFLLAVICIASALLGRSEWILIFPF
                     IPIQITMIDQFVEGFPPFVLTFERNIKPVEPNFLRKSMLRALPSALMVVFSVLFVKIF
                     GSSQGWSELEISTLLYYLLGSIGFLSVFRACMPFTLWRVLLIVWSVGGFLATALFPRI
                     QKLLEISTLTGQTLPVYGVMMLVFTVIFILTSRYQAKK"
     gene            34227..34904
                     /locus_tag="AC0DU4_000033"
     CDS             34227..34904
                     /locus_tag="AC0DU4_000033"
                     /EC_number="2.1.1.217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000624068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:0160105 - tRNA
                     (adenine(22)-N1)-methyltransferase activity [Evidence
                     IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenine(22)-N(1))-methyltransferase"
                     /protein_id="HIN4236084.1"
                     /translation="MISKRLELVASFVSQGAILLDVGSDHAYLPIELVERGQIKSAIA
                     GEVVEGPYQSAVKNVEAHGLKEKIQVRLANGLAAFEETDQVSVITIAGMGGRLIARIL
                     EEGLGKLANVERLILQPNNREDDLRIWLQDHGFQIVAESILEEAGKFYEILVVEAGQM
                     KLSASDVRFGPFLSKEVSPVFVQKWQKEAEKLEFALGQIPEKNLEERQVLVDKIQAIK
                     EVPHVSK"
     gene            34891..35688
                     /locus_tag="AC0DU4_000034"
     CDS             34891..35688
                     /locus_tag="AC0DU4_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000881127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0051540 - metal cluster binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HIN4236085.1"
                     /translation="MLASEVIQAYEAFCPQEFSMEGDSRGLQIGTLDKGIQRVMVALD
                     IREETVAEAIEKGVDLIIVKHAPIFRPIKDLLASRPQNQIYIDLIKHDIAVYVSHTNI
                     DIVENGLNDWFCQMLGIEETTYLQETGPERGIGRIGNIQPQTFWELAQQVKQVFDLDS
                     LRMVHYQENDLQKPISRVAICGGSGQSFYKDALAKGADVYITGDIYYHTAQDMLSDGL
                     LALDPGHYIEVLFVEKIAALLTQWKEKKGWELEILPSQASTNPFRHI"
     gene            35705..36808
                     /locus_tag="AC0DU4_000035"
     CDS             35705..36808
                     /locus_tag="AC0DU4_000035"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HIN4236086.1"
                     /translation="MKKVAIIGAGIVGATAAYYLSRESDLEVTVFDHEQGQATKAAAG
                     IISPWLSKRRNKAWYKMARLGADFYVDLLADLEKSGQEIDFYQRSGVFLLKKDESKLE
                     ELYQLALQRREESPLIGQLSILDQAPANELFPGLQGFDNLLYASGGARVDGHLLVTRL
                     LEASQVKLVKEKVTLTLLSSGYQIGEEVFDQVILATGAWLGDMLEPLGYEVDVRPQKG
                     QLRDYQLAQDMEDYPVVMPEGEWDLIPFAGGKLSLGATHENDMGFDLTVDEPLLQQME
                     EAALPHYPVLARVTSRAERVGIRAYTSDFSPFFGQVPELAGVYAASGLGSSGLTTGPI
                     IGYHLAQLIQDKELTLDPENYPIENYVKRVKSE"
     gene            36815..37006
                     /locus_tag="AC0DU4_000036"
     CDS             36815..37006
                     /locus_tag="AC0DU4_000036"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236087.1"
                     /translation="MKIKEQTRKLAADYSKHCFEVVDRTDEVSSKHCFEVVDRTDEVS
                     NHTHGKATLTWFELDFRRV"
     gene            37109..38128
                     /gene="galE"
                     /locus_tag="AC0DU4_000037"
     CDS             37109..38128
                     /gene="galE"
                     /locus_tag="AC0DU4_000037"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA];
                     GO_process: GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HIN4236088.1"
                     /translation="MQEKILVTGGAGFIGTHTVIELIQAGHQVVVVDNLVNSNRKSLE
                     VVERITGVEIPFYEADIRDTDTLRDIFKQEEPTGIIHFAGLKAVGESTRIPLAYYDNN
                     IAGTVSLLKAMEENNCKNIIFSSSATVYGDPHTVPILEDFPLSVTNPYGRTKLMLEEI
                     LTDIYKADSEWNVVLLRYFNPIGAHESGDLGENPNGIPNNLLPYVTQVAVGKLEQVQV
                     FGDDYDTEDGTGVRDYIHVVDLAKGHVAALKKIQKGSGLNVYNLGTGKGYSVLEIIQN
                     MEKAVGRPIPYRIVERRPGDIAACYSDPAKAKAELGWEAELDITQMCEDAWRWQSKHP
                     NGFED"
     gene            38130..39095
                     /locus_tag="AC0DU4_000038"
     CDS             38130..39095
                     /locus_tag="AC0DU4_000038"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HIN4236089.1"
                     /translation="MMISIIVPCLNEEEVLPLFYQALEALLPDLETEIEYVFVDDGSS
                     DGTLELLKAYREQNPAVHYISFSRNFGKEAALYAGLQYATGDLVVVMDADLQDPPSML
                     FEMKNVLDKNVDLDCVGTRRTSREGEPFFRSFCAVLFYRLMQKISPVALPSGVRDFRM
                     MRRSVVDAILSLTESNRFSKGLFAWVGFKTYYLDYPNVERQAGKTSWSFRQLFFYSIE
                     GIINFSDFPLIIAFVAGLLSCFLSLLMTFFVVVRTLILGNPTSGWTSLMAVILFLGGI
                     QLLTIGILGKYISKIYLETKKRPLYLIKEKSDLPDFTEKNKVKRL"
     gene            complement(39146..39352)
                     /locus_tag="AC0DU4_000039"
     CDS             complement(39146..39352)
                     /locus_tag="AC0DU4_000039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005506 - iron ion binding [Evidence IEA];
                     GO_function: GO:0009055 - electron transfer activity
                     [Evidence IEA];
                     GO_function: GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HIN4236090.1"
                     /translation="MKITLIPERCIACGLCQTYSDLFDYHDNGIVRFYDDPDQLEKEI
                     SPSQDVLEAVKNCPTRALIGNQEA"
     gene            39404..39880
                     /locus_tag="AC0DU4_000040"
     CDS             39404..39880
                     /locus_tag="AC0DU4_000040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAG1386/EF1546 family surface-associated
                     protein"
                     /protein_id="HIN4236091.1"
                     /translation="MAKEPWQEDIYDQEESRAERRHRNHGGADRMANRILTILASIFF
                     VIVVVMVIVLIYLSSGGSNRTAALKDFHDSDASVVQISSSSSSQPEQSSEPESTSSSS
                     EEAANPEGTIKVLAGEGEAAIAARAGISIAQLEALNPGHMATGSWFANPGDVIKIK"
     gene            39889..40560
                     /gene="cmk"
                     /locus_tag="AC0DU4_000041"
     CDS             39889..40560
                     /gene="cmk"
                     /locus_tag="AC0DU4_000041"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004127 - (d)CMP kinase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HIN4236092.1"
                     /translation="MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAATYM
                     ALKNQLGVEEVEALLALLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAI
                     AAIPEVREKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKE
                     NIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAE
                     AEKRM"
     gene            40690..41028
                     /locus_tag="AC0DU4_000042"
     CDS             40690..41028
                     /locus_tag="AC0DU4_000042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002920966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein YjdM"
                     /protein_id="HIN4236093.1"
                     /translation="MNNLPNCPKCNSEYVYEDGALLVCPECAHEWNPAEVAEVEEGLV
                     AIDANGNKLADGDTVTLIKDLKVKGAPKDLKQGTRVKNIHIVEGDHNIDCKIDGFGAM
                     KLKSEFVRKI"
     gene            41031..41660
                     /locus_tag="AC0DU4_000043"
     CDS             41031..41660
                     /locus_tag="AC0DU4_000043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Pr6Pr family membrane protein"
                     /protein_id="HIN4236094.1"
                     /translation="MSKHYKLVFYSRIFLFLAAFTGVYLEITKHGGFGMLLYYTVLSN
                     LLVTIFTLYLLKVMSRVGENWQRPSLLRLKGGVTMSIMITCVIYHFLLAPIATNFYTL
                     ENFLCHYIVPIWFLADTLFFDKQGQYKIWDPAVWTILPFLYMMFALFNGLVLKLNIPN
                     AKDNPFPYFFLNVNKGWNVVFKWCLIIFVAYMVAGFIFYFIKQIKRKSS"
     gene            41900..43051
                     /locus_tag="AC0DU4_000044"
     CDS             41900..43051
                     /locus_tag="AC0DU4_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HIN4236095.1"
                     /translation="MKQFLERASILALSLVLITSFSISSALPAMFDYYQGYSKEQIEL
                     LVSLPSFGIMMMLLLNGFLEKIFPERLQISLGLLILSLSGTAPFWYQAYPFVFGARLL
                     FGLGLGMINAKAISIISERYQGKRRIQMLGLRASAEVVGASLITLAVGQLLAFGWTAI
                     FLAYSAGFLVLPLYLLFVPYGKSKKEVKKRAKEASRLTREMKGLIFTLAIEAAVVVCT
                     NTAITIRIPSLMVERGLGDAQLSSFVLSIMQLIGIVAGVSFSFLISIFKEKLLLWSGI
                     TFGLGQIVIALSSSLWVVVAGSVLAGFAYSVVLTTVFQLVSERIPAKLLNQATSFAVL
                     GCSFGAFTTPFVLGAIGLLTHNGMLVFSILGGWLIVISIFVMYLLQKRA"
     gene            43369..44118
                     /gene="truA"
                     /locus_tag="AC0DU4_000045"
     CDS             43369..44118
                     /gene="truA"
                     /locus_tag="AC0DU4_000045"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HIN4236096.1"
                     /translation="MTRYKATISYDGYAFAGFQRQSHARSVQEEIEKTLTRLNKGQAI
                     TVHGAGRTDSGVHALGQVIHFDLPYQIDEEKLRFALDTQSPEDIDVISIELVADDFHC
                     RYAKHSKTYEFIVDRGRPKNPMRRHYATHFPYPLDVERMQIAIKKLEGTHDFTGFTAS
                     GTSVEDKVRTITEASLIVDETGQFLTFTFSGNGFLYKQIRNMVGTLLKIGNNRMPVEQ
                     IDLILEKKDRQLAGPTAAPNGLYLKEIRYEE"
     gene            44108..44881
                     /locus_tag="AC0DU4_000046"
     CDS             44108..44881
                     /locus_tag="AC0DU4_000046"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HIN4236097.1"
                     /translation="MKNNRILALSGNDIFSGGGLSADLATYTLNGLHGFVAVTCLTAL
                     TEKGFEVFPTDDTIFQHELDSLRDVEFGGIKIGLLPTVSVAEKALDFIKQRPGVPVVL
                     DPVLVCKETHDVAVSELCQELIRFFPYVSVITPNLPEAELLSGQEIKTLEDMKTAAQK
                     LHDLGAPAVIIKGGNRLSQDKAVDVFYDGQTFTILENPVIQGQNAGAGCTFASSIASH
                     LIKGDKLLPAVESSKAFVYRAIAQADQYGVRQYEANKNN"
     gene            44859..45320
                     /locus_tag="AC0DU4_000047"
     CDS             44859..45320
                     /locus_tag="AC0DU4_000047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HIN4236098.1"
                     /translation="MKQTKTTKIALVSLLTALSVVLGYFLKIPTPTGILTLLDAGVFF
                     AAFYFGSREGAVVGGLASFLIDLLSGYPQWMFFSLVNHGLQGFFAGFKGKSQWLGLIL
                     ATIAMVGGYALGSTLMNGWAAALPEILPNFMQNMVGMIVGFILSQSIKKIK"
     gene            complement(45579..45740)
                     /locus_tag="AC0DU4_000048"
                     /pseudo
     CDS             complement(45579..45740)
                     /locus_tag="AC0DU4_000048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884849.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            complement(45775..46857)
                     /locus_tag="AC0DU4_000049"
     CDS             complement(45775..46857)
                     /locus_tag="AC0DU4_000049"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004177 - aminopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_function: GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M24 family metallopeptidase"
                     /protein_id="HIN4236099.1"
                     /translation="MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFL
                     FVLADQEPLLFVPALEVERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFD
                     NLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDN
                     ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFD
                     LGVLVNGYASDMTRTVAVGKPDQFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAARE
                     VIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFSVEPGIYIPGKVGVR
                     IEDCGVVTKDGFDLFTSTSKDLLYFD"
     gene            complement(46983..47765)
                     /gene="gatD"
                     /locus_tag="AC0DU4_000050"
     CDS             complement(46983..47765)
                     /gene="gatD"
                     /locus_tag="AC0DU4_000050"
                     /EC_number="6.3.5.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004359 - glutaminase activity [Evidence
                     IEA];
                     GO_function: GO:0140282 - carbon-nitrogen ligase activity
                     on lipid II [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lipid II isoglutaminyl synthase subunit GatD"
                     /protein_id="HIN4236100.1"
                     /translation="MVYTSLSSKDGNYPYQLNIAHLYGNLMNTYGDNGNILMLKYVAE
                     KLGAHVTVDIVSLHDDFDENHYDIAFFGGGQDFEQSIIADDLPAKKESIDNYIQNDGV
                     VLAICGGFQLLGQYYVEASGKRIEGLGVMGHYTLNQTNNRFIGDIKIHNEDFDETYYG
                     FENHQGRTFLSDDQKPLGQVVYGNGNNEEKVGEGVHYKNVFGSYFHGPILSRNANLAY
                     RLVTTALKKKYGQDIQLPAYEDILSQEIAEEYSDVKSKADFS"
     gene            complement(47765..49108)
                     /gene="murT"
                     /locus_tag="AC0DU4_000051"
     CDS             complement(47765..49108)
                     /gene="murT"
                     /locus_tag="AC0DU4_000051"
                     /EC_number="6.3.5.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016881 - acid-amino acid ligase activity
                     [Evidence IEA];
                     GO_function: GO:0140282 - carbon-nitrogen ligase activity
                     on lipid II [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lipid II isoglutaminyl synthase subunit MurT"
                     /protein_id="HIN4236101.1"
                     /translation="MNLKTTLGLLAGRSSHFILSRLGRGSTLPGKVALQFDKDILQNL
                     AKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMITGIATTFLTAKSSKT
                     GKNIAVLEIDEASLSRICDYIQPSLFVITNIFRDQMDRFGEIYTTYNMILDAIRKVPT
                     ATVLLNGDSPLFYKPTIPNPIEYFGFDLEKGPAQLAHYNTEGILCPDCQGILKYEHNT
                     YANLGTYICEGCGCKRPDLDYRLTKLVELTNNRSRFVIDGQEYGIQIGGLYNIYNALA
                     AVAIARFLGADSQLIKQGFDKSRAVFGRQETFHIGDKECTLVLIKNPVGATQAIEMIK
                     LAPYPFSLSVLLNANYADGIDTSWIWDADFEQITDMDIPEINAGGVRHSEIARRLRVT
                     GYPAEKITETSNLEQVLKTIENQDCKHAYILATYTAMLEFRELLASRQIVRKEMN"
     gene            complement(49207..50523)
                     /locus_tag="AC0DU4_000052"
     CDS             complement(49207..50523)
                     /locus_tag="AC0DU4_000052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000958936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016668 - oxidoreductase activity, acting
                     on a sulfur group of donors, NAD(P) as acceptor [Evidence
                     IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-containing oxidoreductase"
                     /protein_id="HIN4236102.1"
                     /translation="MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCI
                     NIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNGKNYATVAGTGVDIFDAEAHFLS
                     NKVIEIQAGDEKKELTAETIVINTGAVSNVLPIPGLATSKNIFDSTGIQNLDKLPEKL
                     GILGGGNIGLEFAGLYNKLGSKVTVLDALDTFLPRAEPSIAALAKQYMEEDGIELLQN
                     IHTTEIKNDGDQVLVVTEDETYRFDALLYATGRKPNVEPLQLENTDIELTERGAIKVD
                     KHCQTNVPGVFAVGDINGGLQFTYISLDDFRVVYSYLAGDGSYTLEDRLNVPNTMFIT
                     PALSQVGLTESQAADLKLPYAVKEIPVAAMPRGHVNGDLRGAFKAVVNTETKEILGAS
                     IFSEGSQEIINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI"
     gene            50716..51942
                     /locus_tag="AC0DU4_000053"
     CDS             50716..51942
                     /locus_tag="AC0DU4_000053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015129 - lactate transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate MFS transporter"
                     /protein_id="HIN4236103.1"
                     /translation="MKSNRYIIAFAGVILHLMLGSTYAWSVYRNPIIEKTGWDQASVA
                     FAFSLAIFCLGLSAAFMGRLVEKFGPRVMGSLSAFLYAGGNILTGFAIDRQELWLLYL
                     AYGILGGLGLGAGYITPVSTIIKWFPDKRGLATGLAIMGFGFASLLTSPIAQHLIAGV
                     GLVETFYILGASYFIIMLLASQFIKRPNEQELAILSSSGKEKTASLTQGMAANQALKS
                     NRFYILWIIFFINIACGLGLISAASPMAQEMAGLSTSHAAVMVGVLGIFNGFGRLLWA
                     SLSDYIGRPLTFSILLLVNLFFSLSLWLFTDSVLFVVAMSILMTCYGAGFSLIPAYLS
                     DIFGTKELAALHGYILTAWAMAGLAGPILLAETYKMAHSYTQTLFVFLILYSIALALS
                     YYLGRSIKKESQKPLT"
     gene            52141..53715
                     /locus_tag="AC0DU4_000054"
     CDS             52141..53715
                     /locus_tag="AC0DU4_000054"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HIN4236104.1"
                     /translation="MKFNELNLSADLLAEIEKAGFVEASPIQEQTIPLALEGKDVIGQ
                     AQTGTGKTAAFGLPTLEKIRTEEATIQALVIAPTRELAVQSQEELFRFGRSKGVKVRS
                     VYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLQNIETLILDEADEMLNMGF
                     LEDIEAIISRVPENRQTLLFSATMPDAIKRIGVQFMKAPEHVKIAAKELTTELVDQYY
                     IRVKEQEKFDTMTRLMDVAQPELAIVFGRTKRRVDELTRGLKIRGFRAEGIHGDLDQN
                     KRLRVLRDFKNGNLDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAG
                     KSGQSITFVAPNEMGYLQIIENLTKKRMKGLKPASVEESFQSKKQVALKKIERDFADE
                     TIRANFEKFGKDARKLAAEFTPEELAMYILSLTVQDPDSLPEVEIAREKPLPFKPSGN
                     GFGGKAKGGRGGRRGDDRRERDRRGNGRRDEFKKGSRGNDRFDKEKRYRKDNKKPRNT
                     LSEKQTGFVIRNKGDK"
     gene            53979..54767
                     /gene="codY"
                     /locus_tag="AC0DU4_000055"
     CDS             53979..54767
                     /gene="codY"
                     /locus_tag="AC0DU4_000055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HIN4236105.1"
                     /translation="MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNAC
                     IINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIF
                     PVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLN
                     FQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGQLTASVIADRIGITR
                     SVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY"
     gene            54767..55342
                     /locus_tag="AC0DU4_000056"
     CDS             54767..55342
                     /locus_tag="AC0DU4_000056"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase family protein"
                     /protein_id="HIN4236106.1"
                     /translation="MTKALISIDYTEDFVADSGKLTAGAPAQAISDAISKVTRLAFER
                     GDYIFFTIDAHEENDFFHPESKLFPPHNLIGTSGRNLYGDLGIFYQEHGSDSRVFWMD
                     KRHYSAFSGTDLDIRLRERRVSTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVAS
                     IWPENHQFALGHFKNTLGAKLVDENLNELSE"
     gene            55424..55509
                     /locus_tag="AC0DU4_000057"
     tRNA            55424..55509
                     /locus_tag="AC0DU4_000057"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:55458..55460,aa:Leu,seq:aag)
     gene            55792..56922
                     /locus_tag="AC0DU4_000058"
     CDS             55792..56922
                     /locus_tag="AC0DU4_000058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236107.1"
                     /translation="MVELNLKNIYKKYPNSEHYSVEDFNLNIKDKEFIVFVGPSGCGK
                     STTLRMIAGLEDITEGTASIDGVVVNDVAPKDRDIAMVFQNYALYPHMTVYDNMAFGL
                     KLRKYSKEDINKRVQEAAEILGLKEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMD
                     EPLSNLDAKLRVSMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSATKNPAGT
                     GTIGRVEQIGTPQEVYKNPVNKFVAGFIGSPAMNFITVKLVGSEIVSDGFRLKVPEGA
                     LKVLREKGYEGKELIFGIRPEDVNAEPAFLETFPDCVVKATISVSELLGSESHLYCQV
                     GKDEFVAKVDARDYLQTGATVELGFDLNKAHFFDVETEKTIY"
     gene            57421..58179
                     /locus_tag="AC0DU4_000059"
     CDS             57421..58179
                     /locus_tag="AC0DU4_000059"
                     /EC_number="2.1.-.-"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001848902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HIN4236108.1"
                     /translation="MSEAGHKFLAKLGKKRLRPGGKRATDWLIAEGGFSKEKRILEVA
                     CNRGTTAIELAQRFGCKITAVDMDAQALEVAKKSAGTAGVAHLISFERANAMKLPYQD
                     ASFDIVINEAMLTMQADQAKKKCVMEYLRVLKPGGLLLTHDVLLKEAKESIRQELSQA
                     IHVNVGPLTQDGWEQVMIESGYCDVKALTGEMTLMKLSGMIYDEGLLGTLKICVNACK
                     KENRKQFLTMYKMFAKNKQKLGFIAMASYKSSKR"
     gene            58267..58779
                     /locus_tag="AC0DU4_000060"
     CDS             58267..58779
                     /locus_tag="AC0DU4_000060"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA];
                     GO_process: GO:0006168 - adenine salvage [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HIN4236109.1"
                     /translation="MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYA
                     TDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLT
                     MHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIG
                     DYDYKVLMHY"
     gene            58961..59905
                     /gene="metA"
                     /locus_tag="AC0DU4_000061"
     CDS             58961..59905
                     /gene="metA"
                     /locus_tag="AC0DU4_000061"
                     /EC_number="2.3.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004414 - homoserine O-acetyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine O-acetyltransferase MetA"
                     /protein_id="HIN4236110.1"
                     /translation="MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLM
                     PQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTTRSEHMETFYKTFPEVKDEYFDG
                     MIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQM
                     DSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVG
                     VSILASRDLREIYSFGHLEYDRDTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLC
                     WSSSAALFFSNWVNHAVYQETPFDWRKIEDDASAYGYL"
     gene            59914..60591
                     /locus_tag="AC0DU4_000062"
     CDS             59914..60591
                     /locus_tag="AC0DU4_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006269 - DNA replication, synthesis of
                     primer [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HIN4236111.1"
                     /translation="MTYLDAFKSGTLVLPSALLLHFKELFPSSDDFLVWQFFYLQNTT
                     GLEEMSPSQIAERIGKEISDVNQSISNLTERGLLQYRTIELNGEIELLFDASLALERL
                     DDLFGAVHSSSDQLTPQNQLKDLVETFQQELGRLLTPFEIEDLTKTLKEDGTSADLIK
                     EALREAVLNGKPNWKYIQAILRNWRHEGIKSVAQIEAKRAEREASNPQLTQVSADFRN
                     AMDLWKD"
     gene            60689..61447
                     /gene="tpiA"
                     /locus_tag="AC0DU4_000063"
     CDS             60689..61447
                     /gene="tpiA"
                     /locus_tag="AC0DU4_000063"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000087908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004807 - triose-phosphate isomerase
                     activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HIN4236112.1"
                     /translation="MSRKPFIAGNWKMNKNPEEAKAFVEAVASKLPSSDLVEAGIAAP
                     ALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTGETSPQVLKEIGTDYVVIGHSERRDY
                     FHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTAEQV
                     AASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPE
                     NVASYMACPDVDGALVGGASLEAESFLALLDFVK"
     gene            61485..62990
                     /gene="lytC"
                     /locus_tag="AC0DU4_000064"
     CDS             61485..62990
                     /gene="lytC"
                     /locus_tag="AC0DU4_000064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078138769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase LytC"
                     /protein_id="HIN4236113.1"
                     /translation="MSVTFFIGEQRLKTKIGLASICLLGLATSHVAANETEVAKTSQD
                     TTTASSSSEQNQSSNKTQTSAEVQTNAAAHWDGDYYVKDDGSKAQSEWIFDNYYKAWF
                     YINSDGRYSQNEWHGNYYLKSGGYMAQNEWIYDSNYKSWFYLKSDGAYAHQEWQLIGN
                     KWYYFKKWGYMAKSQWQGSYFLNGQGAMMQNEWLYDPAYSAYFYLKSDGTYANQEWQK
                     VGGKWYYFKKWGYMARNEWQGNYYLTGSGAMATDEVIMDGARYIFAASGELKEKKDLN
                     VGWVHRNGKRYFFNNREEQVGTEHAKKIIDISEHNGRINDWKKVIDENEVDGVIVRLG
                     YSGKEDKELAHNIKELNRLGIPYGVYLYTYAENETDAENDAKQTIELIKKYNMNLSYP
                     IYYDVENWEYVNKSKRAPSDTDTWVKIINKYMDTMKQAGYQNVYVYSYRSLLQTRLKH
                     PDILKHVNWVAAYTNALEWENPYYSGEKGWQYTSSEYMKGIQGRVDVSVWY"
     gene            63486..64004
                     /locus_tag="AC0DU4_000065"
     CDS             63486..64004
                     /locus_tag="AC0DU4_000065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Dps family protein"
                     /protein_id="HIN4236114.1"
                     /translation="MVELKKEAVKDVTSLTKAAPVALAKTKEVLNQAVADLYVAHVAL
                     HQVHWYMHGRGFLVWHPKMDEYMEALDGQLDEISERLITLGGSPFSTLTEFLQNSEIE
                     EEAGEYRNVEESLERVLVIYRYLSELFQKGLDVTDEEGDDVTNGIFAGAKTETDKTIW
                     MLAAELGQAPGL"
     gene            64134..64640
                     /locus_tag="AC0DU4_000066"
     CDS             64134..64640
                     /locus_tag="AC0DU4_000066"
                     /EC_number="1.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004146 - dihydrofolate reductase activity
                     [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_process: GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase"
                     /protein_id="HIN4236115.1"
                     /translation="MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAIL
                     MGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQDQEKNLYIIGG
                     KQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTI
                     QYRKRKEV"
     gene            64640..64810
                     /locus_tag="AC0DU4_000067"
     CDS             64640..64810
                     /locus_tag="AC0DU4_000067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000442275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236116.1"
                     /translation="MERSLFGLFTAFLCFICFLAGAQAFRKKRYGLSILLWLNAFTNL
                     VNSIHAFYMTLF"
     gene            64842..66074
                     /gene="clpX"
                     /locus_tag="AC0DU4_000068"
     CDS             64842..66074
                     /gene="clpX"
                     /locus_tag="AC0DU4_000068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002874765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HIN4236117.1"
                     /translation="MSTNRKNDMMVYCSFCGKNQEEVQKIIAGNNAFICNECVELAQE
                     IIREELVEEVLADLSEVPKPIELLHILNHYVIGQDRAKRALAVAVYNHYKRINFHDTR
                     EESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
                     ILLKLLQVADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGT
                     VASVPPQGGRKHPQQEMIQVDTKNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAI
                     DENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVRILKEPRNALVKQYQ
                     TLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLV
                     RITKETVDGTDKPILETA"
     gene            66083..66670
                     /gene="yihA"
                     /locus_tag="AC0DU4_000069"
     CDS             66083..66670
                     /gene="yihA"
                     /locus_tag="AC0DU4_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002915299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTP-binding protein
                     YihA/YsxC"
                     /protein_id="HIN4236118.1"
                     /translation="MELNTHNAEILLSAANKSHYPQDELPEIALAGRSNVGKSSFINT
                     MLNRKNLARTSGKPGKTQLLNFFNIDDKMRFVDVPGYGYARVSKKEREKWGCMIEEYL
                     TTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESA
                     IKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL"
     gene            66681..67061
                     /locus_tag="AC0DU4_000070"
     CDS             66681..67061
                     /locus_tag="AC0DU4_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HIN4236119.1"
                     /translation="MAKTIHTDKAPKAIGPYVQGKIVGNLLFASGQVPLSPETGEIVG
                     ENIQEQTEQVLKNIGAILAEAGTDFDHVVKTTCFLSDMNDFVPFNEVYQTAFKEEFPA
                     RSAVEVARLPRDVKVEIEVIAEIG"
     gene            67113..68003
                     /gene="rapZ"
                     /locus_tag="AC0DU4_000071"
     CDS             67113..68003
                     /gene="rapZ"
                     /locus_tag="AC0DU4_000071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HIN4236120.1"
                     /translation="MTKKQLHLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALLPK
                     FLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDELENQDGLDFKILFLDAADKELVA
                     RYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQFS
                     DQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVM
                     NHPESEDFYQHLLALIEPILPSYQKEGKSVLTIAMGCTGGQHRSVAFAKRLVQDLSKN
                     WSVNEGHRDKDRRKETVNRS"
     gene            68000..68977
                     /locus_tag="AC0DU4_000072"
     CDS             68000..68977
                     /locus_tag="AC0DU4_000072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HIN4236121.1"
                     /translation="MRKPKITVIGGGTGIPVILKSLREKDVEIAAIVTVADDGGSSGE
                     LRKNMQQLTPPGDFRNVLVAMSDMPKFYEKVFQYRFSEDAGAFAGHPLGNLIIAGLSE
                     MQGSTYNAMQLLSKFFHTTGKIYPSSDHPLTLHAVFQDGTEVAGESHIVDHRGIIDNV
                     YVTNALNDDTPLASRRVVQTILESDMIVLGPGSLFTSILPNIVIKEIGRALLETKAEI
                     AYVCNIMTQRGETEHFTDSDHVEVLHRHLGRPFIDTVLVNIEKVPQEYMNSNRFDEYL
                     VQVEHDFVGLCKQVSRVISSNFLRLENGGAFHDGDLIVDELMRIIQVKK"
     gene            68974..69885
                     /gene="whiA"
                     /locus_tag="AC0DU4_000073"
     CDS             68974..69885
                     /gene="whiA"
                     /locus_tag="AC0DU4_000073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0043937 - regulation of sporulation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HIN4236122.1"
                     /translation="MSFTVAVKEEILGQHHLSWHELSAIIKMSGSIGLSTSGLTLSVV
                     TENAKLARHLYESFLHFYEIKSEIRHHQRSNLRKNRVYTVFTDEKVQDLLSDLHLADS
                     FFGLETGIDEAILSDEEAGRAYLCGAFLANGSIRDPESGKYQLEISSVYLDHAQGIAS
                     LLQQFLLDAKVLERKKGAVTYLQRAEDIMDFLIVIGAMQARDDFERVKILRETRNDLN
                     RANNAETANIARTVSASMKTINNISKIKDIMGLENLPVDLQEVAQLRIQHPDYSIQQL
                     ADSLSTPLTKSGVNHRLRKINKIADEL"
     gene            complement(69919..70887)
                     /locus_tag="AC0DU4_000074"
     CDS             complement(69919..70887)
                     /locus_tag="AC0DU4_000074"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000081018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HIN4236123.1"
                     /translation="MSQLYDITIVGGGPVGLFAAFYAHLRQAKVQIIDSLPQLGGQPA
                     ILYPEKEILDVPGFPNLTGEELTNRLIEQLNGFDTPIHLNETVLEIDKQEEEFAITTS
                     KGSHLTKTVIIAMGGGAFKPRPLELESVEGYENIHYHVSNIQQYAGKKVTILGGGDSA
                     VDWALAFEKIAPTTLVHRRDNFRALEHSVQALQESSVTIKTPFAPSQLLGNGKTLDKL
                     EITKVKSDETETIDLDHLFVNYGFKSSVGNLKNWGLDLNRHKIIVNSKQESSQAGIYA
                     IGDCCYYDGKIDLIATGLGEAPTAVNNAINYIDPEQKVQPKHSTSL"
     gene            71023..71880
                     /gene="cdaA"
                     /locus_tag="AC0DU4_000075"
     CDS             71023..71880
                     /gene="cdaA"
                     /locus_tag="AC0DU4_000075"
                     /EC_number="2.7.7.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001867651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004016 - adenylate cyclase activity
                     [Evidence IEA];
                     GO_process: GO:0006171 - cAMP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diadenylate cyclase CdaA"
                     /protein_id="HIN4236124.1"
                     /translation="MNFQQLSNLQYWTSLFASPWTIAINLIDILIVAYILYHFTKAIA
                     GTKIMILVRGVLVFILAQILANMIGLTTISWLINQIITYGVIAAVVIFSPEIRTGLER
                     LGRATDFFSNAPISAEEQMIRAFVKSVEYMSPRKIGALVAIQRVRTLQEYMSTGIPLD
                     AKISAELLINIFIPNTPLHDGAVIIKEERIAVTSAYLPLTKNTGISKEFGTRHRAAIG
                     LSEVSDALTFVVSEETGGISITYNGRFKHNLTLDEFETELREILLPKEEVGLSFKERL
                     LGGWKHEKK"
     gene            71867..72646
                     /locus_tag="AC0DU4_000076"
     CDS             71867..72646
                     /locus_tag="AC0DU4_000076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CdaR family protein"
                     /protein_id="HIN4236125.1"
                     /translation="MKKNSLYIISSLFFACVLFVYATATNFQNSTSARQVKTETYTNT
                     VTNVPIDIRYNSDKYFISGFASEVSVVLTGANRLSLASEMQESTRKFKVTADLTDAGV
                     GTIEVPLSIEDLPNGLTAVATPQKITVKIGKKAQKDKVKIVPEIDPSQIDSRVQIENV
                     MVSDKEVSITSDQETLDRIDKIIAVLPTSERITGNYSGSVPLQAIDRNGVVLPAVITP
                     FDTIMKVTTKPVAPSSSTSNSSTSSSSETSSSTKATSSKTN"
     gene            72670..74022
                     /gene="glmM"
                     /locus_tag="AC0DU4_000077"
     CDS             72670..74022
                     /gene="glmM"
                     /locus_tag="AC0DU4_000077"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0008966 - phosphoglucosamine mutase
                     activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HIN4236126.1"
                     /translation="MGKYFGTDGVRGEANLELTPELAFKLGRFGGYVLSQHETEAPKV
                     FVGRDTRISGEMLESALVAGLLSVGIHVYKLGVLATPAVAYLVETEGASAGVMISASH
                     NPALDNGIKFFGGDGFKLDDEKEAEIEALLDAEEDTLPRPSAEGLGILVDYPEGLRKY
                     EGYLVSTGTPLDGMKVALDTANGAASTSARQIFADLGAQLTVIGETPDGLNINLNVGS
                     THPEALQEVVKESGSAIGLAFDGDSDRLIAVDENGNIVDGDKIMYIIGKYLSEKGQLA
                     QNTIVTTVMSNLGFHKALNREGINKAVTAVGDRYVVEEMRKSGYNLGGEQSGHVILMD
                     YNTTGDGQLSAVQLTKIMKETGKSLSELAAEVTIYPQKLVNIRVENVMKEKAMEVPAI
                     KAIIEKMEEEMAGNGRILVRPSGTEPLLRVMAEAPTTEEVDYYVDTITDVVRAEIGID
                     "
     gene            74096..74470
                     /locus_tag="AC0DU4_000078"
     CDS             74096..74470
                     /locus_tag="AC0DU4_000078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1149 family protein"
                     /protein_id="HIN4236127.1"
                     /translation="MNLKREQEFVSQYHFDARNFEWENENGAPETKVDVNFQLLQHDQ
                     ENQVTSLIVILSFMIVFDKFVISGTISQVNHIDGRIVNEPSELNQEEVETLARPCLNM
                     LNRLTYEVTEIALDLPGINLEF"
     gene            74472..75320
                     /locus_tag="AC0DU4_000079"
     CDS             74472..75320
                     /locus_tag="AC0DU4_000079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HIN4236128.1"
                     /translation="MKLAVFTDSSAYLSEETLQREDLFVLDIPVNIDGEEYVEGINLS
                     AEEFYQKMAQASELPKTSQPSIAKLDEILTSLKEQGYTHALGLFLSSGISGFYQNIQY
                     MVDDYEGLTIAFPDTLITSAPLGIMVESVFNWRDQGDDFASIQDKLAIQISRTSAFIM
                     VDDLDHLVKGGRLSNGAAILGNLLSIKPILYFNDQGVIEVYEKVRTEKKATKRLIEII
                     KETTASGQYRVIVIHGNAPEKAEELRQHLLDFGLGSDVSLATFGSVIGTHLGAGSIAL
                     GYIPVI"
     gene            75597..76364
                     /gene="dapB"
                     /locus_tag="AC0DU4_000080"
     CDS             75597..76364
                     /gene="dapB"
                     /locus_tag="AC0DU4_000080"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008839 - 4-hydroxy-tetrahydrodipicolinate
                     reductase [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HIN4236129.1"
                     /translation="MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQ
                     GIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELK
                     EFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKT
                     AELMAEVRESIQQGAADEEELIAGARGADFDGMHIHSVRLPGLVAHQEVIFGNQGEGL
                     TLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL"
     gene            76361..77560
                     /locus_tag="AC0DU4_000081"
     CDS             76361..77560
                     /locus_tag="AC0DU4_000081"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0001680 - tRNA 3'-terminal CCA addition
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HIN4236130.1"
                     /translation="MRLTQMPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHNPIH
                     DVDIATSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSA
                     VSFVRSLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDA
                     LRIMRGFRFQASLGFALEPETFKAMKTLTPLLENISVERTFVEFDKLLLAPFWRRGLA
                     SMIESQAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSFLKS
                     WKTSRQFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAI
                     TEKYQSLTIHDKKEIQINGGILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIH
                     AYLREKK"
     gene            77557..79428
                     /locus_tag="AC0DU4_000082"
     CDS             77557..79428
                     /locus_tag="AC0DU4_000082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001279112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HIN4236131.1"
                     /translation="MSDFIVEKLSKSVGDKTVFRDISFIIHDLDRIGLIGVNGTGKTT
                     LLDVLSGVSGFDGDVSPFSAKNDYQIGYLTQDPDFDDRKTVLDTVLSSELKEIQLIRE
                     YELIMLDYSEDKQARLERVMAEMDSLQAWEIESQVKTVLSKLGIQDLSTPVGELSGGL
                     RRRVQLAQVLLGNHDLLLLDEPTNHLDIAIIEWLTLFLKNSKKTVLFITHDRYFLDAL
                     STRIFELDRAGLTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMRRQPQAR
                     ATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQAVSFAYENKPILQD
                     FNLLVQAKDRIGIVGDNGVGKSTLLNLIAGSLEPTKGQVVIGETVRIAYFSQQIEGLD
                     ESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHGTLIEKLSGGEKKRLYLL
                     KLLLEKPNVLLLDEPTNDLDIATLTVLENFLQGFAGPVLTVSHDRYFLDKVATKILAF
                     EDGKIRPFFGHYTDYLDEKAFETDMANQVQKVEKEKVVKVREDKKRMTYQEKQEWASI
                     EGDIETLEKRIAAIEEEMQANGSDFGKLATLQKELDEKNEALLEKYERYEYLSEFDS"
     gene            complement(79571..80755)
                     /gene="mntE"
                     /locus_tag="AC0DU4_000083"
     CDS             complement(79571..80755)
                     /gene="mntE"
                     /locus_tag="AC0DU4_000083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDF family manganese efflux transporter MntE"
                     /protein_id="HIN4236132.1"
                     /translation="MKQSISNLKLAERGAIISISTYLILSAAKLATGHLLHSSSLVAD
                     GFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLITSIIMFYVGFDVLRD
                     TIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSKALKAAAKDNLSDA
                     VTSLGTAIAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLED
                     YQKAIMEIPKISKVKSQRGRTYGSNIYLDITLEMNPDLSVFESHEIADQVESMLEERF
                     GVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQDGEQM
                     DKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETK
                     KE"
     gene            81059..83755
                     /locus_tag="AC0DU4_000084"
     CDS             81059..83755
                     /locus_tag="AC0DU4_000084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015662 - P-type ion transporter activity
                     [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0019829 - ATPase-coupled monoatomic cation
                     transmembrane transporter activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HIN4236133.1"
                     /translation="MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHN
                     ELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAF
                     GVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLR
                     LIEANSLKIEEAALTGESVPVEKDLSVELATDAGIGDRVNMAFQNSNVTYGRGMGVVV
                     NTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKN
                     PLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIA
                     SDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIG
                     DPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDGRFLVAVKGA
                     PDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLT
                     SEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGI
                     IDANDTEGHVLTGAELNELSDEEFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAM
                     TGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNI
                     QKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGV
                     MNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALT
                     MAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMAIIVVEPLEGI
                     FHVTKLDLSQWGIVMAGSFSMIIIVEIVKFIQRKLGFDKNAI"
     gene            83768..84559
                     /gene="yghU"
                     /locus_tag="AC0DU4_000085"
     CDS             83768..84559
                     /gene="yghU"
                     /locus_tag="AC0DU4_000085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_process: GO:0006749 - glutathione metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-dependent disulfide-bond
                     oxidoreductase"
                     /protein_id="HIN4236134.1"
                     /translation="MSAYQLPTVWQDEASNQGAFTGLNRQTAGARFEQNLPKGEQAFQ
                     LYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKIAIMDGDQFGSDFVKLNPNSKIPAL
                     LDQSGTEDVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLGGGFG
                     HFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADIAIWSWYGQLV
                     QENLYQGSAKFLDASSYQNLVKWAEKIANRPAVKRGLEVTYTEIK"
     gene            84675..85085
                     /locus_tag="AC0DU4_000086"
     CDS             84675..85085
                     /locus_tag="AC0DU4_000086"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HIN4236135.1"
                     /translation="MEKKIVKDNLFLSQVSQPASQEDLYLARDLQDTLLANRDTCVGL
                     AANMIGVQKRVIIFNLGLVPVVMFNPVLLSFEGSYEAEEGCLSLVGVRSTKRYETIRL
                     AYRDSKWQEQTITLTGFPAQICQHELDHLEGRII"
     gene            85097..86692
                     /locus_tag="AC0DU4_000087"
     CDS             85097..86692
                     /locus_tag="AC0DU4_000087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000822862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236136.1"
                     /translation="MKRIVFELIFIATTWYIFLPPLNLTSWEFLFFLCGHLLVVAILF
                     GFGKGINLVKTVHVRHGKAEAALNLEGFKINRLGKILLASIGGILLLAALVSLVTSSM
                     FQAKNYANVVTVTEKDFTEFPRSDTSKVPILDRSTAEKIGDRYLGSLTDKVSQYVAAD
                     TYTQLTIDGKPYRVTPLEYADPIKWFNNQAKGIGEYIKVDMVTGNADLVDLKTPIKYS
                     DSEYFNRDVKRHLRLKYPTKIFKTPSFEVDDEGNPFYVATVYQKQFGLAVPRPASVII
                     LDATNGETKEYSLSDVPEWVDRIYPAEETIEQINYNGKYKDGFLNAMISKKNVTQTTK
                     GYNYLSIGNDIYLYTGVTSANADESNLGFILENMRTGEITKYSLASATEESARESAEG
                     AVQEKSYKATFPILINLNDKPLYIMGLKDNAGLVKEYALVDAVEYQNVIVATTVEEML
                     SKYANKNDLEIDNATTESINGVVADLKSAVIKGDTVYFFKVDGKIYKVKASVSDDLPY
                     LENGKTFEGQVGKDNYLKTFKLR"
     gene            86759..86923
                     /locus_tag="AC0DU4_000088"
     CDS             86759..86923
                     /locus_tag="AC0DU4_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000508323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YczI family protein"
                     /protein_id="HIN4236137.1"
                     /translation="MGFYLMVASMLLGLLALKIGFSQFKEKKDKFLSILTSLAGTALV
                     LVAVWLGWPK"
     gene            87002..87730
                     /gene="yaaA"
                     /locus_tag="AC0DU4_000089"
     CDS             87002..87730
                     /gene="yaaA"
                     /locus_tag="AC0DU4_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HIN4236138.1"
                     /translation="MKILIPTAKEMNTDLPSIEAIPLKPESQTVLDALALYSASQLES
                     FYKVSAEKAAEEFQNIQALKRQTAQHYPALKLFDGLMYRNIKRDKLTEAEQDYLENHV
                     FITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAVYDEALKKEEVIFSLLSS
                     EFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARR
                     LNFAGFVYREDLSQPQGLVFVKEV"
     gene            complement(88008..88556)
                     /locus_tag="AC0DU4_000090"
     CDS             complement(88008..88556)
                     /locus_tag="AC0DU4_000090"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008752 - FMN reductase [NAD(P)H] activity
                     [Evidence IEA];
                     GO_function: GO:0008753 - NADPH dehydrogenase (quinone)
                     activity [Evidence IEA];
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050136 - NADH:ubiquinone reductase
                     (non-electrogenic) activity [Evidence IEA];
                     GO_function: GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="HIN4236139.1"
                     /translation="MSKKVLFIVGSLRQGSFNHQMALEAEKALASKAEVSYLDYSALP
                     LFSQDLEVPTHPAVAAAREAVLVADAIWIFSPVYNFSIPGTVKNLLDWLSRALDLSDT
                     RGVSALQDKFVTVSSVANAGHDQLFAIYKDLLPFIRTQGVGDFTAARVNDSAWADGKL
                     VLEETVLNSLEKQAQDLVEAIK"
     gene            88877..89386
                     /locus_tag="AC0DU4_000091"
     CDS             88877..89386
                     /locus_tag="AC0DU4_000091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5590 domain-containing protein"
                     /protein_id="HIN4236140.1"
                     /translation="MKKRQNKAKNNLLWQYGLGMTILFVVISGSFLYMVSLSMKPYQT
                     AKSEGEKLAQQYAGLEQVDQVDLYNGLESYYSVLGRNKQQEALAVLIGKDDHKIYVYQ
                     LNQGVSQEKAETVSKEKGAGEIDKIIFGRYQDKPIWEVKSGSDFYLVDFETGALVNKE
                     GLWNYPTVF"
     gene            89362..90549
                     /locus_tag="AC0DU4_000092"
     CDS             89362..90549
                     /locus_tag="AC0DU4_000092"
                     /EC_number="2.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008483 - transaminase activity [Evidence
                     IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HIN4236141.1"
                     /translation="MELSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTT
                     PKNIQDAAIASIRDGRASFYTVTSGLPELKAAVNSYFERFYGYSVASNQVTVAAGAKY
                     SLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEAA
                     RTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTP
                     ISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQ
                     YAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAME
                     MKGYTDVTDFTTVILEEAEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGS
                     END"
     gene            90542..90907
                     /locus_tag="AC0DU4_000093"
     CDS             90542..90907
                     /locus_tag="AC0DU4_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HIN4236142.1"
                     /translation="MIDHFEIKVKDLQISEGFYRSFLAPLDYKLAFKTSSLISFLSPN
                     SPHPGGDFWLTQGTQDPVHFAFLAENKEEVQACYEAGLEAGGRDNGAPGYRSEHPIYY
                     AAFVIDLDGNNIEVVCHKE"
     gene            90926..92269
                     /gene="asnS"
                     /locus_tag="AC0DU4_000094"
     CDS             90926..92269
                     /gene="asnS"
                     /locus_tag="AC0DU4_000094"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730396.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004816 - asparagine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HIN4236143.1"
                     /translation="MTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTAF
                     FQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITDI
                     EVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGFM
                     KFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRAE
                     KSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTEL
                     LKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPTF
                     VMNYPAAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDELG
                     MDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP"
     gene            92422..92712
                     /gene="rpsF"
                     /locus_tag="AC0DU4_000095"
     CDS             92422..92712
                     /gene="rpsF"
                     /locus_tag="AC0DU4_000095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018030687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HIN4236144.1"
                     /translation="MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKTWE
                     KRRLAYEIQDFREGLYHIVNVEANDDAALKEFDRLSKINADILRHMIVKIDA"
     gene            92724..93194
                     /gene="ssbA"
                     /locus_tag="AC0DU4_000096"
     CDS             92724..93194
                     /gene="ssbA"
                     /locus_tag="AC0DU4_000096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein SsbA"
                     /protein_id="HIN4236145.1"
                     /translation="MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGER
                     EADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQM
                     LESRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF"
     gene            93226..93465
                     /gene="rpsR"
                     /locus_tag="AC0DU4_000097"
     CDS             93226..93465
                     /gene="rpsR"
                     /locus_tag="AC0DU4_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HIN4236146.1"
                     /translation="MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKI
                     LPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED"
     gene            93760..95160
                     /locus_tag="AC0DU4_000098"
     CDS             93760..95160
                     /locus_tag="AC0DU4_000098"
                     /EC_number="3.1.3.-"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA];
                     GO_function: GO:0016791 - phosphatase activity [Evidence
                     IEA];
                     GO_process: GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional Cof-type HAD-IIB family
                     hydrolase/peptidylprolyl isomerase"
                     /protein_id="HIN4236147.1"
                     /translation="MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLRE
                     KGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIEKSDVEEYI
                     SWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFED
                     KGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDG
                     LNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQV
                     DIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMI
                     QGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLP
                     YSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDAIAAVETGAM
                     DKPVEDVVIETIEIED"
     gene            95162..95521
                     /locus_tag="AC0DU4_000099"
     CDS             95162..95521
                     /locus_tag="AC0DU4_000099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HIN4236148.1"
                     /translation="MKIGDKLKGRITGIQPYGAFVELETGDTGLIHISEIRTGFIENI
                     HETLKVDEEVQVQVVDLDEFTGKASLSIRTLEEEKYQFPRRRRFSSDRFNYGFAPFRR
                     MLPIWTGEALHHLKKKK"
     gene            95575..96324
                     /locus_tag="AC0DU4_000100"
     CDS             95575..96324
                     /locus_tag="AC0DU4_000100"
                     /EC_number="2.1.1.223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008170 - N-methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:0016430 - tRNA
                     (adenine-N6)-methyltransferase activity [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HIN4236149.1"
                     /translation="MEEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPR
                     FPKKGLIVDFCAGNGAVGLFASTRTQAQILSVEIQERLADMAERSVRLNGLEEQMQVI
                     CDDLKNMPAHIQGSKVDMILCNPPYFKVNPYSNLNESEHYLLARHEITTNLEEICRSA
                     QSILKSNGRLAMVHRPDRLLDILDTLKRHNLAPKRLQFVYPKREKEANMLLIEAIKDG
                     STSGFKVLPPLIVHNDDGSYTPEIEEIYYGS"
     gene            96314..96613
                     /locus_tag="AC0DU4_000101"
     CDS             96314..96613
                     /locus_tag="AC0DU4_000101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HIN4236150.1"
                     /translation="MDHKAYMYVLECRDGSYYIGYTTDMRRRLAIHNSGKGAKYTRAR
                     LPVKLIYAQGFASKEEAMSAEALLKRKKRPQKEEFLSENQDRNLLSYFEESWGVL"
     gene            96684..97619
                     /locus_tag="AC0DU4_000102"
     CDS             96684..97619
                     /locus_tag="AC0DU4_000102"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004427 - inorganic diphosphate
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="manganese-dependent inorganic pyrophosphatase"
                     /protein_id="HIN4236151.1"
                     /translation="MSKILVFGHQNPDSDAIGSSVAFAYLAKEAYGLDTEAVALGTPN
                     EETAFVLNYFGVEAPRVITSAKAEGAEQVILTDHNEFQQSVSDIAEVEVYGVVDHHRV
                     ANFETASPLYMRLEPVGSASSIVYRMFKEHGVAVPKEIAGLMLSGLISDTLLLKSPTT
                     HPTDKIIAPELAELAGVNLEEYGLAMLKAGTNLASKSAEELIDIDAKTFELNGNNVRV
                     AQVNTVDIAEVLERQAEIEAAMQAANESNGYSDFVLMITDIVNSNSEILALGANMDKV
                     EAAFNFKLENNHAFLAGAVSRKKQVVPQLTESFNA"
     gene            97705..98217
                     /locus_tag="AC0DU4_000103"
     CDS             97705..98217
                     /locus_tag="AC0DU4_000103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000892254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YiiX/YebB-like N1pC/P60 family cysteine
                     hydrolase"
                     /protein_id="HIN4236152.1"
                     /translation="MLENGDLIFVRDGSDMGQAIQTSTGNYSHVAIYLDGMIYHASGQ
                     AGVVCQEPADFFESNHLYDLYVYPEMDIQSVKERACKHLGAPYNASFYPDAPGFYCSQ
                     YIAEILPIFETIPMKFGDGEQEISDFWREYYIELGLPVPLNQAGTNPSQLAASPLLQC
                     KERNLHDSDF"
     gene            98201..98850
                     /locus_tag="AC0DU4_000104"
                     /pseudo
     CDS             98201..98850
                     /locus_tag="AC0DU4_000104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000614493.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1803 domain-containing protein"
     gene            98951..99148
                     /locus_tag="AC0DU4_000105"
     CDS             98951..99148
                     /locus_tag="AC0DU4_000105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HIN4236153.1"
                     /translation="MSLENKLEQATGAVKEGFGKVTGDSKTELEGAVEKTVAKAKDVV
                     EDAKGAVEGAVEGLKNVFTKE"
     gene            complement(99191..100636)
                     /locus_tag="AC0DU4_000106"
     CDS             complement(99191..100636)
                     /locus_tag="AC0DU4_000106"
                     /EC_number="6.3.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-
                     lysine ligase"
                     /protein_id="HIN4236154.1"
                     /translation="MIKIETVLDILKKDGLFREIIDQGHYHYNYSKVVFDSISYDSRK
                     VTEDTLFFAKGAAFKKEYLLSAITQGLAWYVAEKDYEVGIPVIIVNDIKKAMSLIAME
                     FYGNPQEKLKLLAFTGTKGKTTAAYFAYNILSQGHRPAMLSTMNTTLDGETFFKSALT
                     TPESIDLFDMMNQAVQNDRTHLIMEVSSQSYLVRRVYGLTFDVGVFLNISPDHIGPIE
                     HPSFEDYFYHKRLLMENSRAVIINSDMDHFSVLKEQVEDQDHDFYGSQFDNQIENSKA
                     FSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAATRVPGRMEV
                     LTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLN
                     QHPEIQVFLTADDPNYEDPMAIADEISSYINHPVEKIADRQEAIKAAMAITNHELDAV
                     IIAGKGADCYQIIQGKKESYPGDTAVAENYL"
     gene            100742..102364
                     /locus_tag="AC0DU4_000107"
     CDS             100742..102364
                     /locus_tag="AC0DU4_000107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="putative polysaccharide biosynthesis protein"
                     /protein_id="HIN4236155.1"
                     /translation="MSHENNHQQAQMLRGTAWLTASNFISRLLGAVYIIPWYIWMGAY
                     AAKANGLFTMGYNIYAWFLLVSTAGIPVAVAKQVAKYNTMREEEDSFALIRSFLGFMT
                     GLGLVFALVLYVFAPWLADLSGVGKDLIPIMQSLAWGVLIFPSMSVIRGFFQGMNNLK
                     PYAMSQIAEQVIRVIWMLLATFIIMKLGSGDYLAAVTQSTFAAFVGMVASFAVLIYFL
                     AQEGSLKRVFETGDKINSKRLLVDTIKEAIPFILTGSAIQLFQILDQLTFINSMSWFT
                     NYSNEDLVVMFSYFSANPNKITMILISVGVSIGSVGLPLLTENYVKGDLKAASRLVQD
                     SLTLLFMFLLPATVGVVMVGEPLYTVFYGKPDSLALGLFVFAVLQSIILGLYMVLSPM
                     LQAMFRNRKAVLYFIYGSIAKLVLQLPTIALFHSYGPLISTTIALIIPNVLMYRDICK
                     VTGVKRKVILKRTILISLLTLVMFLLIGTIQWLLGFFFQPSGRLWSFFYVALVGAMGG
                     GLYMVMSLRTYLLDKVIGKAQADRLRAKFKLS"
     gene            102567..104525
                     /locus_tag="AC0DU4_000108"
     CDS             102567..104525
                     /locus_tag="AC0DU4_000108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4236156.1"
                     /translation="MKKSKSKYLTLAGLVLGTGVLLSACGNSSTASKTYNYVYSSDPS
                     SLNYLAENRAATSDIVANLVDGLLENDQYGNIIPSLAEDWTVSQDGLTYTYKLRKDAK
                     WFTSEGEEYAPVTAQDFVTGLQYAADKKSEALYLVQDSVAGLDDYITGKTSDFSTVGV
                     KALDDQTVQYTLVKPELYWNSKTLATILFPVNADFLKSKGDDFGKADPSSILYNGPFL
                     MKALVSKSAIEYKKNPNYWDAKNVFVDDVKLTYYDGSDQESLERNFTAGAYTTARLFP
                     NSSSYEGIKEKYKNNIIYSMQNSTSYFFNFNLDRKSYNYTSKTSDIEKKSTQEAVLNK
                     NFRQAINFAFDRTSYGAQSEGKEGATKILRNLVVPPNFVSIKGKDFGEVVASKMVNYG
                     KEWQGINFADGQDPYYNPEKAKAKFAEAKKELEAKGVQFPIHLDKTVEVTDKVGIQGV
                     SSIKQSIESVLGSDNVVIDIQQLTSDEFDSSGYFAQTAAQKDYDLYHGGWGPDYQDPS
                     TYLDIFSVKNGGVLQNLGLDPGEANDKAKAVGLDTYTQMLEEANKEQDPAKRYEKYAD
                     IQAWLIDSSLVLPSVSRGGTPSLRRTVPFAAAYGLTGTKGVESYKYLKVQDKIVTTDE
                     YAKAREKWLKEKEESNKKAQEELAKHVK"
     gene            104697..105632
                     /locus_tag="AC0DU4_000109"
     CDS             104697..105632
                     /locus_tag="AC0DU4_000109"
                     /inference="COORDINATES: protein motif:HMM:NF012869.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236157.1"
                     /translation="MKLKLLRVDTKVIMGSFLLVLSSLLALLLPLILKGLIDGSSIEN
                     IGSKVFQSFLIFIGQALFSSIGYYLFSQSGEKKIAKIRKKVIEGLIYAEKSFFDKSQS
                     GELTSAIVNDTSVIREFLITTFPNIILSLVMVLGSIVVLFSLDWNLSLLLFITLPCMM
                     FIILPLSNISEKYSRRLQEEIGFLTGQLTEKIQEHELIKTNQAEKSVQDVLDNCIERV
                     QNNSLKSDRVTSFETPFALLFIFATIAVMLTYGGYRVSAGYISVGTLVSFLIYLFQLL
                     NPISNIANFVTVYSRSKGSSVALENLLAVPKEKFE"
     gene            105657..106379
                     /locus_tag="AC0DU4_000110"
     CDS             105657..106379
                     /locus_tag="AC0DU4_000110"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236158.1"
                     /translation="MNFNHVYFGYDENRPVLKDITCSIFKGQKIAFVGPSGSGKSTIV
                     RLLEQFYKPLSGDILMEQSSIYDFNLKEWRSKIAWVSQNNAVLSGSIRDNLCLGLNRL
                     VTDDELMKVLDLVSLGDEIRSMKEGLDTEVGERGRFLSGGQSQRLQIARTYLKDAEIL
                     IFDEATANLDADSEYAIISSLYSVLKEKTVVIIAHSLSTVKDVDCIFFLEEGKITGSG
                     THKELLENHERYARFVQEQMIE"
     gene            106536..107630
                     /locus_tag="AC0DU4_000111"
     CDS             106536..107630
                     /locus_tag="AC0DU4_000111"
                     /EC_number="2.5.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HIN4236159.1"
                     /translation="MSKELHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGRST
                     GFDYTRTKNPTRSKAEEVLATIESADYALATSSGMSAIVLAFSGFPVGSKVLAVRDLY
                     GGSFRWFNQVEQEGRFHFTYANTEEELIAELEKDVDVLYIETPTNPLMLEFDIEKLAK
                     LAHAKGAKVVVDNTFYSPIYQRPIEDGADIVLHSATKYLAGHNDVLAGVVVTNSLELY
                     EKLFYNLNTTGAVLSPFDSYQLLRGLKTLSLRMERSTANAQEVVAFLKDSPAVKEVLY
                     TGRGGMISFKVADETRIPHILNSLKVFSFAESLGGVESLITYPTTQTHADIPAEVRHS
                     YGLTDDLLRLSIGIEDARDLIADLRQALEG"
     gene            107638..108804
                     /locus_tag="AC0DU4_000112"
     CDS             107638..108804
                     /locus_tag="AC0DU4_000112"
                     /EC_number="4.4.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_function: GO:0047804 - cysteine-S-conjugate beta-lyase
                     activity [Evidence IEA];
                     GO_process: GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MalY/PatB family protein"
                     /protein_id="HIN4236160.1"
                     /translation="MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPE
                     IRQVVQTYADQLVYGYTYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAI
                     QTFTKEGDAVLINTPVYPPFARSVKLNNRRLITNSLVEKDGLFEIDFDQLEKDLVEEE
                     VKLYILCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTI
                     NPAFKNFAIVLSSATKTFNIAGTKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLA
                     TEAAYRYGKDWLEELKQVFEDHINYVVDLFGKETKIKVMKPQGTYLIWLDFSAYDLTD
                     ETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR"
     gene            108897..111995
                     /locus_tag="AC0DU4_000113"
     CDS             108897..111995
                     /locus_tag="AC0DU4_000113"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0004386 - helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HIN4236161.1"
                     /translation="MAKLIPGKIRIEGVALYETGKVDIIKEKNNRLYARVAEEELRYS
                     LEDDLVFCACDFFQKRGYCVHLAALEHFLKNDERGQEILWSLEEGHEEKEAVETKVTL
                     GGKFLDRILSPKSECAYELSAVGQVEAGTNHILWTLRIGQINSQKYYVIRDIPLFLRI
                     VEQRKSYMIGKIYEESLSWEAFDDASQELLTFLHGLTEEGLVSDLFFQNQGRHLFFPL
                     TFFEQGVNLLMALPHFQFDHQVDSYQTLLFQDMHADANLFAFTVTEYSDYFEMEISES
                     PRVNVFYQGAVLFHKGQVYFLTDQQMRLLKEIKALPVGQQGKKYLQFDSSDRDKLASC
                     LTLFIQMGTVSAPERLQIKTFAPSFYFDREEDNRIRLEIQFDYGNRQVSSRQELEELP
                     FSSDADLEERIFQVCLAAGFEADFQSWRQALKAESVYHFFHDIIPVFEKLGHVDLSDK
                     LEELYSLASPQVQIASKGGLLEIQFDFQNIVQEEIDQAMQALVANQDFYIDSSNQVYF
                     FDEETKKIRQNLQELGQFELKDGTLQARKSLTYSLAHLFEGRDRVSFSQEFQNLAQDL
                     THPEDFPLQATQVKADLRDYQEKGIGWLQMLHHYGFGGILADDMGLGKTLQTIAFLTS
                     QVTKESRVLILAPSGLIYNWADEFQKFAPQLDVTVVHGLKASREEILAESHQIYVTSY
                     ATFRQDSELYQGMAFDFLFLDEAQVMKNAQTKIAQTLRQFVVPSVFALSGTPIENHLG
                     ELWSIFQIVMPGLLPSKKEFMKLPAERVAQFIKPFVMRRKKEEVLTELPDLIEVVYKN
                     ELEDQQKAIYLAQLQQMRDHLAQVSEQEFQRSRVEILSGLMRLRQICDTPALFMEDYQ
                     GASGKLDSLRDLLVQVADGGHRVLIFSQFKGMLEKIEQELPDLGLTSFKITGSTPAKE
                     RQDMTKAFNQGERDAFLISLKAGGVGLNLTGADTVILVDLWWNPAVEAQAIGRAHRMG
                     QEETVEVYRLVTKGTIEEKIQELQEQKKHLVSQVLDGTESRGSLTLAEIREILGISEA
                     ST"
     gene            112043..112660
                     /locus_tag="AC0DU4_000114"
     CDS             112043..112660
                     /locus_tag="AC0DU4_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HIN4236162.1"
                     /translation="MKQERFPLVSDDEVMLTEMPVMNLYDESDLISNIKGEYRDKNYL
                     EWAPIAEEKPVKPIEKQVEKPKKAPLGVKKEGKSYAEVAREEARADLKKKRSANYLTQ
                     DFSLARRHSQPSLVRQGNQPTTPFQKENPGEFVKYSQKLTQSHYILAEEVHSIPTKNE
                     EVSAPAPKKNNYDFLKKSQIYNKKSKQTEQERRVAQELNLTRMTE"
     gene            112671..114005
                     /gene="murC"
                     /locus_tag="AC0DU4_000115"
     CDS             112671..114005
                     /gene="murC"
                     /locus_tag="AC0DU4_000115"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008763 - UDP-N-acetylmuramate-L-alanine
                     ligase activity [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HIN4236163.1"
                     /translation="MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGL
                     EQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIAYADQNGISYKRYHEFLGSFMRD
                     FVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF
                     MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDA
                     PIYYYGFEAEGNDFVASDLLRSTTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIG
                     LLYTAGFDLNLVREHLKTFAGVKRRFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKY
                     PSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLAN
                     KINKKHQVITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ"
     gene            114015..114479
                     /locus_tag="AC0DU4_000116"
     CDS             114015..114479
                     /locus_tag="AC0DU4_000116"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236164.1"
                     /translation="MEIPIKIIQASKFDLPEIGALQTSSFPAEKQQLSHILEESIRKC
                     ADTFLLARDENQLLGYILSSPQSDNPQCLKVHSLVIESDHQRQGLGTLLLAALKEVAV
                     ELDYKGIRLESPDELLSYFEMNGFVDEEEILLYATSQGYSMIWFNPFYLEEQ"
     gene            114476..114970
                     /locus_tag="AC0DU4_000117"
     CDS             114476..114970
                     /locus_tag="AC0DU4_000117"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000702438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236165.1"
                     /translation="MKIRQARLEDLDRIVELEFENFSVEEAIPPSVFEAHLREIQTSF
                     LVAEKEGRIMGYIEGPVGLHRHLQDQSFTEEIKDYSHEPGGYISVTCLSIAKEAQGLG
                     LGQKLLTALKEVALEDERDGINLTCHDYLIAYYEKHGFVNEGQSQSTFAGETWYDMVW
                     EMKK"
     gene            115051..116706
                     /gene="mltG"
                     /locus_tag="AC0DU4_000118"
     CDS             115051..116706
                     /gene="mltG"
                     /locus_tag="AC0DU4_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008932 - lytic endotransglycosylase
                     activity [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HIN4236166.1"
                     /translation="MSEKSREEEKLSFKEQILRDLEKVKGYDEVLKEDEAVVRTPANE
                     PSAEELMADSLSTVEEIMRKAPTVPTHPSQGVPASPADEIQRETPGVPSHPSQDVPSS
                     PAEESGSRPGPGPVRPKKLEREYNETPTRVAVSYTTAEKKAEQAGPETPTPATETVDI
                     IRDTSRRSRREGAKPVKPKKEKKSHVKAFVISFLVFLALLSAGGYFGYQYVLDSLLPI
                     DANSKKYVTVGIPEGSNVQEIGTTLEKAGLVKHGLIFSFYAKYKNYTDLKAGYYNLQK
                     SMSTEDLLKELQKGGTDEPQEPVLATLTIPEGYTLDQIAQTVGQLQGDFKESLTAEAF
                     LAKVQDETFISQAVAKYPTLLESLPVKDSGARYRLEGYLFPATYSIKESTTIESLIDE
                     MLAAMDKNLSPYYSTIKSKNLTVNELLTIASLVEKEGAKTEDRKLIAGVFYNRLNRDM
                     PLQSNIAILYAQGKLGQNISLAEDVAIDTNIDSPYNVYKNVGLMPGPVDSPSLDAIES
                     SINQTKSDNLYFVADVTEGKVYYANNQEDHDRNVAEHVNSKLN"
     gene            116777..117259
                     /gene="greA"
                     /locus_tag="AC0DU4_000119"
     CDS             116777..117259
                     /gene="greA"
                     /locus_tag="AC0DU4_000119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018370745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HIN4236167.1"
                     /translation="MAEKTYPMTLEEKEKLEKELEELKLVRRPEVVERIKIARSYGDL
                     SENSEYEAAKDEQAFVEGQISSLETKIRYAEIVNSDAVAQDEVAIGKTVTIQEIGEDE
                     EEVYIIVGSAGADAFAGKVSNESPIGQALIGKKTGDTATIETPVGSYDVKILKVEKTA
                     "
     gene            complement(117316..117774)
                     /locus_tag="AC0DU4_000120"
     CDS             complement(117316..117774)
                     /locus_tag="AC0DU4_000120"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236168.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDRTDEVSSKHGFEVVDETDEVS
                     SKHGFEVVDETDEVSSKHCFEVVDETDEVSSKHCFEVVDETDEVSSKHSFEVVDETDE
                     VSSKHCFEVVDETDEVSSKHCFEVVNETDKVSNHTYGKATLTWFEEIFEE"
     gene            117902..118300
                     /locus_tag="AC0DU4_000121"
     CDS             117902..118300
                     /locus_tag="AC0DU4_000121"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236169.1"
                     /translation="MENKESHKSQEIGNLIRVYNRSKREEAESEPLNLYVEDEKGNLL
                     AGLIAETFGNWLEIEYLFVKEELRGQGIGSKLLQQAESEAKNRNCCFAFVNTYQFQAP
                     DFYQKHGYKEVFYLQDYLYIRQRYYYQKNL"
     gene            118758..>119091
                     /locus_tag="AC0DU4_000122"
     CDS             118758..>119091
                     /locus_tag="AC0DU4_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236170.1"
                     /translation="MQNHYTTKGEHLTIDSRRLIERWKKEGKSNREIASLLGKVPQTI
                     HTEIKRGTVRQCLGKGRFKEVYSADYAQQSYENNRKRSVKKSSLTKELKEKILHYHNQ
                     KFSPEMMVM"
BASE COUNT        35036 a        22241 c        27080 g        34734 t
ORIGIN      
        1 atggaccgtg atgatgagca ctcagctcac acagaccgtc gttatgcttc acttgacgac
       61 tcagtaatcc cagatgctga aaacttgaaa gtgactttgg aacgtgctct tccattctgg
      121 gaagataaaa tcgctccagc tcttaaagat ggtaaaaacg tattcgtagg agctcacggt
      181 aactcaatcc gtgcccttgt aaaacacatc aaaggtttgt cagatgatga gatcatggac
      241 gtggaaatcc ctaacttccc accattggta ttcgaattcg acgaaaaatt gaacgttgtt
      301 tctgaatact accttggaaa ataaaaaatt gtaagcctag gattgatttc taggcttttt
      361 atgttagtat ggaagtatga taaggaataa aaaacaagat tatgtactgg cctacaaaca
      421 accagcttca accacttaca tgggttggga agaagaagct ttaccgatag gtaatggttc
      481 tttaggagca aaagtatttg gccgtatagg ggctgaacgg attcaattta atgaaaaaag
      541 tctctggtct ggaggtccac ttcctgatag ttcagattat cagggtggaa atcttcagga
      601 tcagtatgtt tttttagctg agattcggca ggctttggag aagagagatt acaatctggc
      661 taaggaactg gctgagcagc acctaattgg gccaaaaacg agtcaatatg ggacctatct
      721 gtcttttggg gatattcaca ttgagttcag ccagcaaggt acgactttgt ctcaggtgac
      781 ggactatcag agacagctga atattagtaa ggcacttgtg acgacttctt atgtctataa
      841 gggaacgcga tttgaacgtg aagcttttgc gagttttcca gatgatctct tggttcagcg
      901 ttttactaag gaaggggcgg aaactctaga ttttactata gaactatcct tgacctgtga
      961 tttggcttct gatgaaaagt atgagcagga aaaatctgat tacaaggagt gtaagttgga
     1021 tattactgat tctcatatct tgatgaaggg aagagttaag gataatgatc tgcggtttgc
     1081 tagttatcta gcttgggaaa cggatggaga tattagagtt tggtcagata gggttcagat
     1141 atcaggagcc agttatgcca atctcttctt ggccgctaag acggattttg cccaaaatcc
     1201 tgctagcaat tatcgcaaga aactagattt agagcaacag gtgatagact tggtggacac
     1261 agctaaagaa aagggctata cccaattgaa atcaaggcat atcgaggact accaagcctt
     1321 attccagcgt gttcaattgg atttggaagc tgatgttgac gcatccacta cagatgattt
     1381 gttaaaaaat tataagccac aagaagggca ggctttggag gagctgttct tccagtatgg
     1441 acggtattta ttgattagtt cgtccagaga ctgcccagat gctctaccag ctaacctaca
     1501 gggagtctgg aatgcggtcg acaatcctcc ttggaattcg gactatcact taaatgtcaa
     1561 tctgcagatg aattattggc cagcctatgt taccaatctc ctagaggcgg tctttccggt
     1621 catcaactat gtagatgatt tgcgtgtcta tggtcgtcta gcggctgtaa agtatgcagg
     1681 aatcgtctct cagaaaggtg aggaaaatgg ttggttggtt catactcaag cgactccctt
     1741 tggttggacg gcacctggtt gggattacta ttggggttgg tcaccagctg ccaatgcgtg
     1801 gatgatgcaa accgtttatg aagcctattc attttatagg gaccaagact atctcaggga
     1861 gaaaatttat cccatgttga gggaaacggt tcgtttttgg aatgcctttt tacataagga
     1921 tcagcaggcg cagcgttggg tgtcttctcc gtcttattct ccagaacatg ggccgatttc
     1981 gattggcaat acctatgacc aatctctgat ttggcagtta tttcatgatt ttattcaggc
     2041 tgctcaggaa ttgggactgg atgaggactt gttgactgag gttaaggaga agtctgattt
     2101 actaaatcct ttgcaaatca ctcaatctgg tcgaatcagg gagtggtatg aggaggaaga
     2161 gcagtatttt caaaatgaga aagtggaggc ccagcaccgg cacgcttccc atctagtggg
     2221 actctatcct ggcaatctct ttagctacaa gggacaagag tatattgaag cggcgcgtgc
     2281 tagcctcaat gatcgtggag atggcggcac aggctggtcc aaggctaata agatcaatct
     2341 ctgggcgcgt ttgggagatg gcaatcgagc ccataaatta ttggcagagc agttaaagac
     2401 atccaccttg ccaaatcttt ggtgtagcca tcctcctttt cagatagatg gtaattttgg
     2461 tgctactagt ggcatggcag aaatgttact ccagtctcat gcagcttatc tggtacctct
     2521 agctgcccta cctgatgctt ggtcaacagg ttctgtttca ggcttaatgg cacgtggaca
     2581 ttttgaagtg agcatgagct gggaagataa aaaactctta cagttgacca ttttatcaag
     2641 gagtggagga gatttgcgag tttcttatcc agatattgag aagagtgtga ttaaaatgaa
     2701 tcaagaaaaa ataaaagcga aatgcatggg gaaagattgt atttcggtgg caacagcaga
     2761 aggtgatctt gttcaatttt atttttaaga agatgttata aggcagtaat ttgaaactgc
     2821 cttttaataa ggatttaaga atataagcag ttttcaacta gttgaaaaag cgttataatg
     2881 ataataggaa gtaatactca atgaaaatca aagagcacaa acaaggaagc tagccgcagg
     2941 ttgctcaaaa cagtgttttg aggttgcaga tggaagctga cgtggtttga agagagattt
     3001 tcgaggagta taatttgttt gatagagggt gggtctgatg gcttatattg agatgaaaca
     3061 ctgttacaag cgttatcagg ttggggacac ggagattgtg gccaatcgtg atgtgaattt
     3121 tgagattgaa aagggggagc tggttattat ccttggtgct tcaggtgcag gcaagtcaac
     3181 agtgcttaac cttcttgggg gaatggatac caatgatgaa ggggaaatct ggattgatgg
     3241 tgttaatatt gcggattata gttcccacca gcgcaccaat taccgtagaa atgatgtggg
     3301 gtttgttttt cagttttata atctagtttc taatctgaca gctaaggaaa atgtggaact
     3361 ggcttctgaa attgtgacag atgccttgaa tcctgatcag gtcttgacag atgtaggtct
     3421 ggctcatcgt ctaaataact ttccagccca gctttctgga ggggagcaac agcgagtctc
     3481 cattgcacgc gcggtagcca aaaatcctaa aattcttctt tgtgatgaac ctactggagc
     3541 cttggattat cagacgggca agcaggtttt gaaaattctc caagatatgt ctcgtcaaaa
     3601 gggagcgacg gtgatcatcg tgactcataa tggagctttg gcgcccattg ctgatcgcgt
     3661 gattcatatg cacgatgcca gtgtcaagga tgtggtgctc aaccagcatc ctcaggatat
     3721 tgacagtttg gagtactagt atgatcaagc gaaaaactta ttggaaggac ttaattcagt
     3781 ccttcacagg ctccaagggg tgttttttat ccatcttgat cctgatgatg ttgggatctc
     3841 tagccttagt aggcctcaaa gtaaccagtc ccaacatgga ggcgacagct aatgcttatt
     3901 taacaactgc tcaaaccttg gatttggcag tcatgtctaa ctatggcttg gatcaagcag
     3961 accaagaaga actaaaacag acggagggcg cagaggtcga gtttggctat ttgacagatg
     4021 tgactatgga taatgggcag gatgccattc ggctgtactc caaaccagag cgaatttcaa
     4081 cctttcagct aagaaaggga cgacttcctc agtcagacaa ggaaatcgct ttggccactc
     4141 atttgcaagg ccaatacagc gtgggacagg agattagttt taaagaaaaa gaagagggtc
     4201 attcctcttt aaaagaccat acttatacca ttactggttt tgtggattcg gctgaaatcc
     4261 tctcccagcg agatatgggc tacgcaggaa gtggaagtgg gactctgaca gcctatgggg
     4321 tgattttacc tagtcagttt gatcagaaag tctacaatat agctcgtttg aaatatcaag
     4381 atttagcagg tttaaatgtc ttttcatcag cttatgaaga aaaatccaag caacatcagg
     4441 aagagcttga acaaatttta tcagataatg gcaaggtacg tctgcaactt ttgaaaaaag
     4501 aaggacaaga gtctctagac aaggggcaag agacccttga caaggctcag actaatttgc
     4561 aggaaggcaa gcgtcgttta gcagctgctc aagctcgtat acaggctcaa gaaagtcaac
     4621 tagccttgtt tcctcaagtt cagagagagc aggctagtgc tcaacttacc caagccaagc
     4681 aggaattggg caaggaagag gacaaactaa agcaagctga acaaaatcta gcccaagaaa
     4741 aggaaaaatt agaaaaacat cagcaagtct tggacgattt ggcggagcca aggtatcagg
     4801 tctataatcg tcagaccatg ccaggtggtc agggctatct tatgtatagc aatgcttcat
     4861 ccagtattcg agcagtgggc aatatctttc ctgtggtact ttatgccgta gcagccatgg
     4921 tgacctttac gaccatgact cgctttgtag acgaagagcg aactcatgca gggattttta
     4981 aggccttggg ttatcgtagt aaggatatta tcgccaagtt tctcctttat ggactagtag
     5041 ctgggactgt cggaacggct ctaggtagta tacttggtca ttatttgcta gccagtgtaa
     5101 tttcaagtgt cattacaaaa ggcatggtgg tgggagaaac ccagattcag ttctattgga
     5161 cctatagctt actagctttt gtcttgagct tgttggcgag tgtgttacca gcctatctgg
     5221 tggcttggag ggaacttcat gacgaagcag cccagcttct acttcctaaa cctcctgtca
     5281 aaggagctaa aatcttattg gagcgtatcg gttttatctg gcgtcgtctc agttttactc
     5341 ataaggtaac agcccgcaac atctttcgtt ataagcagag aatgttgatg acaatctttg
     5401 gtgtggcagg ttctgtagct ctgctctttg caggtttggg aatccaatct tctgtagcag
     5461 gagttccgtc taaacagttt caacaaatcc aacagtatca gatgcttgtc tctgaaaatc
     5521 ctagtgcgac caatcaggac aaggtagagc tagcagaagt gttgaaaggg caggagatac
     5581 tagcctacca gaaaatctat tctaaagcgc tatacaagga tttcaaaggc aaagctggtc
     5641 ttcaaaacat tactcttatg atgatagaga aggaagattt gactcccttt atccatcttc
     5701 aacatcatca gcaggagctg acattaaaag atggcatcgt tattacagct aaactcgccc
     5761 agctggcagg tgtcaaggtt gggcagactt tagaaattga aggtaaggaa ctaaaggtcg
     5821 ctgctattac tgagaactac gttggtcact ttatttatat gagtcaggct agctatgagc
     5881 aactttacgg acagctaccc caagccaaca cttatctggt ctcattaagg gataccagtg
     5941 caactagtat cgaaagtcag gcgggcttgc ttatgaatca atctgcggtg tccagcgttg
     6001 tccaaaatgc ttcagccatt cgactcttcg actctatcgc tagctcactc aatcagacca
     6061 tgaccatctt ggtcatcgta tcggttctat tagctattgt catcctttac aatctgacca
     6121 atatcaacgt agctgagaga atccgtgaac tctccactat caaggttctt ggttttcata
     6181 ataatgaagt caccctctac atttaccgtg agacgattgt gctgtccctt gtgggaatcg
     6241 tacttggtct gatagctggt ttctatttac accaattttt gattcaaatg atttcgcctg
     6301 cgactattct cttttatccg caggtaggct gggaagtcta tgtaatccca gtggcagcag
     6361 taagcatcat tttgaccttg cttggtttct tcgtcaatta ttatctgaga aaggttgata
     6421 tgttagaagc cctgaaatct gtagagtaag gtagttattt ttagctgatt gaacttctat
     6481 ttactaatat tcaaaaatcc tccgtttcaa agagcaggga actctttgtg acagaggatt
     6541 ttttctatag ggctttagca gctgcaattg cggcttcgaa gtttggctca gaattgatat
     6601 tatccacgta ttcaacgtag cgaatcgtat tgtcagtatc gaggacaaag actgcgcgtg
     6661 ctaataggtg ccattcgttg atcaagaggg cataatcgtg cccgaaagaa tggtcaaagt
     6721 agtctgaaag cataatggca ttgtcaaggc cttcagcacc gcaccaacgt ttttgagcaa
     6781 aaggtaggtc cattgaaaca gtcaatacga ccgtgttgtc cagtccagcc aattcttcat
     6841 taaaacgacg tgtttgagtt gagcagatgc ctgtatcgat agaaggaacg acactcaaga
     6901 cttttttctt gccatcaaaa tcagccagag attttttaga aagatctgtt gtagtaagag
     6961 aaaaatcaag cgccttgtcg ccgacttgta gttgtttacc tgtaaagctc acaggatttc
     7021 cgagaaaagt taccatagga tactccaatc ttttttcttc cattgtatct gaaacagtca
     7081 gaattttcca atgatttgac cggaaatgtg ggcatagaaa aaacgccagc tcatatgaga
     7141 atgacgtttt tcagaggctt attttgccaa tccttcagca atcttgtcaa ggttgtattt
     7201 catcatgctg tagtagctgt cgccttcttt accttgttct gcgatagagt cagtaaagat
     7261 ttgtgcgtag attgggatgt ttgtgtcttg agaaacggtt ttcattggac ggtcatccac
     7321 acttgattct acaaagagtg atggaacttt tgtttggcga agtttttcaa ccaaggtctt
     7381 gatttgttca ggagttcctt cttcttcagt attgatttcc cagatgtagg cacttggaac
     7441 accataggct ttagagaagt atttgaatgc tccttcgctg gttacaatga gtttcttttc
     7501 agcagggatc ttattaaatt tatccttact ttctttatca agtttgtcta acttatcagt
     7561 atattctttg agattttttt catagaattc tttattgtta gggtctttgg cgctcaattg
     7621 tttggcgata tttttagcaa aaataatacc gttttcaagg ttaagccaag cgtgtgggtc
     7681 ttcttttcct ttttcatttt gaccttcaag gtagataaca tcaacgccgt cgctgactgc
     7741 gaagtagtct ttgttttcag ttttcttggc attttctacc aattttgtaa accaagcatt
     7801 gccacctgtt tcaaggttga taccgttata gaaaatcaaa tcagcctcag aagttttctt
     7861 aacgtcttca ggaagtggtt cgtattcgtg tgggtcttgc ccaatcggaa cgatactatg
     7921 aaggtcaatt ttgtcaccag caatattttt agtaatatca gcgatgattg agtttgtagc
     7981 aacaactttt agtttttgac cagaagttgt tgcttttttt ccgctagcac atgctacaag
     8041 aatgattgca gaaagaaaga gaacgagtaa tgtacctaat tttttcatta gatcctccaa
     8101 tttattaggg ctttgcccct tattttaaca aatgtttatt tttcagtttc aaatatcgtt
     8161 gtttgggagc gataaagaag ctaatgagaa agaaactagc agctgtaagc acgatactag
     8221 aacctgccgc aacattaaaa ctatagccaa taaagagtcc caaaactgaa gcagtagctc
     8281 cgaaggttga ggaaaggaaa atcatgcttt tcagactatt agcatacaga taagcagttg
     8341 cagctggggt aatcagcatg gctacaatca ggatagttcc gacactttgc atggctgtca
     8401 cagacacgag agtcaggagt accatgagaa ggtagtgata gaaattgaca ggcattccca
     8461 tggctttagc caagagttca tcaaaggaag ttatcaagag ttgcttgaag aaaatccaga
     8521 ttaacaagag gatggctgcc cccacaccca tagtaataaa catatccgta tcttggacgg
     8581 ccaggatatt accaaaaagg atatggaaaa ggtcagttga acttttagcg acaccaatca
     8641 agatgatacc gagggctaag aaagaagaaa aggtaatgcc gatggcggta tcgcttttga
     8701 taatcgagtt tcctttgatg taggtaatga tgatggcagc tagcaatcca aagacaatgg
     8761 ctccgataaa gaagtcaagg cccaagatga aggagagggc tacacctggt aagacagcat
     8821 gtgaaatggc atctcccatg agtgacatcc cgcgtagaat aatgaaacat cccacggctc
     8881 cagctacaat cccgacgaca atagctgtta tcaaggcatt ttgtaggaaa tggaattttt
     8941 gcaatccatc gataaattct gcaatcatag gtcacctcca ttgaaaaaga gttgattacc
     9001 gtaagcttct tttagattgg tttcggtaaa agtttctttt gttggaccaa aggcaatcac
     9061 ttctcgattg acaagtaaga cttgatcgaa gtagtgggga atcttgctga ggtcgtggtg
     9121 aacgatgaga accgtcttcc cagctttttt caaatctctc agcgtattca tgatgatttc
     9181 ctcactgaca gagtcaatcc cagcaaaggg ttcatccaag aggatatagt cggcttcctg
     9241 caccaaacat ctggcaatca agacccgctg gaattgacct ccagacagtt gactaatttg
     9301 acgttcagcg tagtcagcta ggccgacgat ttcaagggcc tcttgcactt tcttccaatg
     9361 tttagccttt aaacttcgaa agagaggaat agagggaaat agtcctaacg agacgcattc
     9421 cttgaccttg atgggaaagt tgtagtcgat attgattttt tgttcgacat aggcaattcg
     9481 gtgtaaggat tttttaactt ccttgtcatc gagaaatgcc tgaccttgat gtgggataat
     9541 tcccagcata ccttttaata gtgttgattt cccagcgccg tttggaccaa tgatgccggt
     9601 aattgttggt ccatggagca ctagtgaaat atccttaagt gccaacgttt ctttgtagga
     9661 gacactgagg ttttcgatac gtatcataaa cttgtattcc tcctgtctct taatatacat
     9721 taaaaaaaaa attaagtcaa gttaattttt gaaaaaatta aaataataac tgaaaaatag
     9781 attctaaaga taactttcag gataaatttc taaattataa aacgcatagt atcaagtgta
     9841 aaaaacttgg aattatgcgt tttatcatgg aaagattttt tataatagct aaaaaataat
     9901 agttaaatgg ttattaattg cattccctag tgatttttgt taagataaat gcaaatacaa
     9961 atgaaagcga gaacaagatg acacgttatc aagatgattt ttatgatgct atcaatggag
    10021 aatggcaaca gacagctgaa atcccagcag ataagtctca aactggaggt tttgttgatt
    10081 tagaccagga aattgaagac ctgatgctgg cgacaacaga caagtggtta gcaggtgaag
    10141 aagtgcctga ggatgctatc ttggaaaact ttgtcaaata ccaccgccta gttcgtgatt
    10201 ttgacaagag agaagctgac ggtatcacac ctgtcttacc actccttaaa gaattccaag
    10261 aattggaaac ttttgcggat tttacagcta aactagcaga gtttgagctt gcaggaaaac
    10321 caaacttcct tccttttggt gtatcgccag actttatgga tgctagaatc aatgttctat
    10381 gggctagcgc tccaagcaca atcttgccag atacgaccta ctatgcagaa gaacatcctc
    10441 agcgcgaaga gctcttgact ctttggaaag aaagcagcgc aaatctcctc aaggcttatg
    10501 atttctctga tgaagaaatt gaagacttgc tagaaaaaag acttgaattg gaccgccgag
    10561 ttgcgacagt ggtgctctct aatgaagaaa gttcagaata tgctaaactc tatcatccat
    10621 attcttacga agatttcaag aaattcgcgc ctgccctacc tttggatgac ttcttcaaag
    10681 cagttattgg gcaattacca gacaaggtta ttgtagacga ggaacgtttc tggcaagcag
    10741 cagagcaatt ctacagtgag gaagcctggt ctctccttaa agcaaccttg attttgagtg
    10801 ttgtcaatct ttcaaccagc tatttaacag aggatatccg tgttttgtct ggtgcctaca
    10861 gccgtgccct ttctggagtt ccagaggcaa aagataaggt caaagcagct tatcatctag
    10921 cacaggaacc tttcaagcaa gccctggggc tttggtacgc ccgtgagaag ttctctccag
    10981 aagccaaggc ggatgtggag aaaaaagtgg caaccatgat tgatgtctat aaggagcgtc
    11041 tgcttaagaa tgactggctc actccagaaa cctgtaaaca ggctatcgtg aagctcaatg
    11101 tgatcaaacc ttatattggc tatccagaag aattgcctgc acgttacaag gataaggtag
    11161 tgaatgaaac tgccagtctt tttgagaatg ctctagcctt tgcgcgtgtg gaaatcaagc
    11221 acagttggag taagtggaac cagcctgtag actataagga atggggcatg cctgctcata
    11281 tggtcaatgc ctactacaat cctcagaaga acctgattgt ctttccagcg gccattttac
    11341 aggcgccttt ctatgacttg catcagtcat cttctgctaa ctacggtggt attggggcag
    11401 tgattgccca tgaaatttcc cacgcctttg atactaacgg ggcttccttt gacgaaaatg
    11461 gtagcctcaa ggattggtgg acagagagcg actatgctgc cttcaaggag aaaacacaaa
    11521 aagtcattga ccaatttgat ggacaggatt cttatggagc aaccattaac ggtaaattga
    11581 ctgtatcaga aaacgtggct gacttgggag gaatcgcagc agcgcttgaa gcagctaaga
    11641 gagaagcaga cttctcagca gaagagttct tctacaactt cggtcgcatc tggcgcatga
    11701 aaggtcgtcc agaatttatg aaacttttgg ctagcgtcga tgtgcacgca ccagccaaac
    11761 tccgtgtcaa tgtgcaagta ccaaacttcg acgatttctt tacaacctat gatgtcaaag
    11821 aaggagacgg aatgtggcgt tcaccagagg agcgcgtgat tatttggtaa tacaaaaaat
    11881 ctagtcatca gaaaaaaggc atccaatcac gtgtgaaaac cttgatagga tgccttttgt
    11941 aatagaaaga tttgctggat agtttactta aatttcgatt gtcatcatct tgctagaaaa
    12001 agggattgaa ggccttttcg tgagcgatag tagtagctgg accatgtcct ggatagacat
    12061 cgtagtttgg tagggtgaag agttgggtct ggatactatg aaggagttgc tccatgctac
    12121 cagtcggaag gtcggtccgt ccgatagttt cgcggaatag agcatctccc gtcaagacta
    12181 ggtgagcatc aggaaagact agggaaacac caccgataga gtgccctggg gtcggtagaa
    12241 ccttaaaacg aaattcctct agttggtatt cttcgtgaaa gacaaaggtg tgttctgcag
    12301 gttttgtgac cacatctgcc atatcatcgt ggcgagggag accggagaga ttatcgacag
    12361 gagtgtagag ccagctggct tcgctctctg cgatatagac aggaggattg ccaaacgtct
    12421 cgcgaaccaa gtccagactc atgatatggt cataatgggc gtgggtcaag agaatagcac
    12481 agatcggttt gttgatcttc tcgattgtct gacgaatggc ttcccaatga ctaccaggat
    12541 cgacgacgat gaggtgcttt tcgccttcta gataataggt attttcatag gcaacaggat
    12601 tcacggtttt atggattttc atactagctc caatctcaaa gaatgtacta atactcttcg
    12661 aaaatctctt caaaccgcgt caactttatc tgcaacctca aagcagtgct ttgaacagcc
    12721 tgcggctagc tttctagttt gctctttgat tttcattgag tataaattaa gtatagcaca
    12781 gttagggaga ataggtaagg atttaaaatg aacttaaaaa ccagcatgac tagatgaaga
    12841 caggctggtt atcaatttat caatattgga aaggtgtcaa ttgcccttca taggttgcat
    12901 aaactccgtc attagcttgt ttgatagacg tgatgtttag agtgctaccg tagttggctt
    12961 ctcatttgtc gctatattca ctataagtta tcctactggg caggttctgg tcgttagcat
    13021 agtattgaac gactgttttt tatagttttg ctggctgaat aggaacaggc agcaaactcc
    13081 taacattagg agagcaaaga tagaaatagc agtttttttc ataggtattc tccttataaa
    13141 ctaaaggata gaagaaagta tcttgaggat ttttatactc ttcaaaaatc tcttcaaacc
    13201 gcgtcaacgt cgccttgccg tatatatgtg actgactttg tcagtcttat ctacaacctc
    13261 aaagcagtgc tttgaacagc ctgcggctag tttcctagtt tgctcttgga ttttcattga
    13321 gtattaattc caaaatccag tcaaggtacc agtgtatgtg atacgagttc caccgtttat
    13381 ctttcgtatc ttcaatggaa ttggggaaat cagaaagtct ttgggttaca atatggtttc
    13441 cgttcttcta tctctccttc tatcacctaa gtttaaaatc taacttcgta gtatattatg
    13501 ggccaataat tcagaattat caagcaattt tgaattattt ttttcttatt ctgttccaat
    13561 ctagttttca tattcttaaa aaagtgataa aatggtagga agaattggag agtagagatg
    13621 ccgaaagaag tgaatttaac aggcgaagaa gttgtcgctt taaccaaaga atatttaacg
    13681 gaagaggatg ttcattttgt ccataaggcc ttggtctatg ctgttgaatg ccacagtggt
    13741 caatatcgca aatcaggcga gccttatatc attcacccta tccaagtggc aggtatttta
    13801 gctaagctaa agctggatgc tgtaacagta gcttgtggat tcttgcatga tgtggtggaa
    13861 gatacagatg cgaccttgga cgatttggaa agagagtttg gtcctgatgt gcgggtgatt
    13921 gttgacggag ttaccaagct tggcaaggtc gagtacaaat cgatcgagga gcaattagcg
    13981 gaaaatcatc gcaagatgct catggccatg tctgaggaca tccgcgttat tttggtcaaa
    14041 ctgtctgacc gcttgcacaa tatgcggacc ctgaaacatc ttcgaaaaga caagcaggag
    14101 cgtatttcca aagaaaccat ggaaatctat gccccacttg cccatcgttt ggggatttcc
    14161 agtgtcaaat gggaattaga agacttgtct ttccgttatc tcaatccaac ggagttttac
    14221 aagattaccc atatgatgaa ggaaaagcgc agggagcgtg aggccttggt ggatgaggta
    14281 gtcacaaaat tagaggagta tacgacagaa cgtcacttga aagggaagat ttatggtcgt
    14341 cccaagcata tttactcaat tttccgcaaa atgcaggaca agagaaaacg gtttgaggaa
    14401 atctatgatc tgattgctat tcgttgtatt ttagataccc aaagtgatgt ttatgccatg
    14461 cttggttacg tgcatgaatt ttggaaaccg atgccaggtc gcttcaaaga ctatattgcc
    14521 aaccgcaagg ccaatggtta tcagtctatc catacgactg tttatggacc aaaagggccg
    14581 attgaattcc agattcgaac caaggaaatg cacgaggtgg ctgagtacgg ggttgcggct
    14641 cactgggctt ataagaaagg tataaagggg caagttaaca gcaaggaatc agctattgga
    14701 atgaactgga tcaaggagat gatggagctc caagaccagg ctgatgatgc taaggaattt
    14761 gtggactctg ttaaggaaaa ctatttggct gaggagattt acgtttttac cccagatgga
    14821 gctgtccgtt cccttcccaa agattcagga ccgattgatt ttgcctacga aatccatacc
    14881 aaggtcggtg aaaaagcaac tggtgccaag gtcaatggcc gcatggttcc actgacaacc
    14941 aagttaaaga caggggatca ggttgaaatt atcgccaacc cgaactcctt tggacctagc
    15001 cgtgactggc tcaatatggt caagactagc aaggcgcgca ataagattcg ccagttcttt
    15061 aaaaaccaag ataaggaatt gtctgtcaac aagggtcgtg agatgctgat ggatcagttc
    15121 caagaaaatg gctatgtggc aaataaattt atggacaagc gccacatgga tcaagttctg
    15181 caaaagacca gttacaagac agaagactcc ctctttgcgg ccattggttt tggggaaatc
    15241 ggtgcgatta ccgtctttaa ccgtctgact gaaaaggagc gccgtgagga agagcgtgcc
    15301 aaggccaagg ctgaggcaga ggagcttgtc aaaggtggcg aggtcaaggt tgaaaataaa
    15361 gaaactctca aggtcaagta tgagggggga gtggttattg aaggtgcttc tggtctccta
    15421 gtgcggattg ctaagtgttg taaccccgtg cctggtgacg atattgttgg ctacattacc
    15481 aagggtcgtg gtgtggctat tcaccgtgtg gactgtatga acctgcgtgc ccaagaaaac
    15541 tacgagcaac gtctccttga tgtggaatgg gaagaccagt actctagctc aaataaggag
    15601 tatatggccc atatcgatat ctacggtctc aaccgtacag gactgttgaa cgatgtactg
    15661 caagttcttt caaatacaac caagaatatt tcaacggtca atgcccaacc aaccaaggat
    15721 atgaagtttg ctaatatcca tgtgtccttc ggtattgcca acctctctac actgactacg
    15781 gttgtcgata aaattaagag tgtgccagaa gtttactctg tcaaacggac caacggctag
    15841 ttgtcctagc tcttactaga aaggctatta tgaaaatcat tatccaacgg gttaaaaaag
    15901 cccaagtgag tatagaaggc cagattcagg gaaaaatcaa tcagggactt ttattgctgg
    15961 ttggtgttgg accagaggac caagaggaag atttggacta tgctgtgaga aaactggtca
    16021 atatgcgaat tttttcagac gcagaaggca agatgaacct atctgtcaaa gatattgaag
    16081 gagaaatcct ctctatttct cagtttaccc tctttgcgga tactaagaaa ggcaatcgtc
    16141 cagcctttac aggggtagct aaacctgata tggcatcaga cttctatgat gctttcaatc
    16201 aaaaattagc gcaagaagtg cccgttcaga caggtatctt tggagcaaat atgcaggttg
    16261 agctggttaa taacggacct gttaccatta tcctagatac taaaaagaga taagaaagac
    16321 caagcccagt cggcttggtc tttctcatct atcataaaat actccaaaaa gaaatcggtt
    16381 cttgatatgc ttgggggaag tctcttttca ggctttggca gatgcgatag gaagggatga
    16441 gatgtcctag gatgaggaga gttccctgaa ggaaaagtgg aatatcactt aaagacacca
    16501 aggagagaat catcaggcta tcccatagga gaatttgtaa agcaaaacgc cagaatctcg
    16561 gtctaatctg ggaatagagt tgactaaagt ggtcacaaag ttggtttgaa agataggtca
    16621 atagcacagg atgaaagaaa atgagccaac cgctataaat caaaatccag tcccaagtaa
    16681 gccccccttt ttaaatgtca aaaatgccag catgattcca tcaatgacaa ggagttgaat
    16741 ggttttgatg aagatgattt ttttcatgct aaaacctcct tttccttaga gacactcccc
    16801 tacaggtatt ttagaatgta tattgcttag atattcctta ttttattagc tttttaaggt
    16861 attaaagtag ttatataagt ttatgaaggg tatcctatcc tgcacggcta attttgagtt
    16921 cgaaactgag gagtttataa ctcaaaattt cgattaaatc agcatttaac gatagtatgt
    16981 ttgtcataaa atgataaatt tttagattgt ggaaattttt tttaacttaa ttcttgattt
    17041 tttttctaaa tgtgatatac ttaatttacg ggataaaaaa accaccttag aaaggtgtga
    17101 taatgtgcaa aaagagaatg ttagaatgcg tttagcgtct gaatccagac agatattaga
    17161 taagcttaaa gatgatgttt acaataaatt aggctatgaa gtaagctatt ccagtattgt
    17221 tagtcaagct gttagagaat acgttcctaa aaaagaacgt atagattgga taaaattaaa
    17281 agagacagct ataccctttt catcgttaaa acagagcaat aattgggagt accagacatc
    17341 acttatgtta gaggaagatg tattaatctt actgtctgaa ctacaaaatt ttttcttaga
    17401 tgtcttccaa gcgaaacgta tacatagggc attttgtgta cgcctatgct tgaaagcaca
    17461 atttttatta agtaataatg attcttaata ctatcaatat taatgcggag tgtaatgctc
    17521 cgctaaaata aaacctatta cgggataaaa acactacttt atttaggatg gaaagaggaa
    17581 cgaatgaaga tgaaagctag agattcacca ttgaattgat tttgttttta gaaaaaatca
    17641 ataattagaa aaaatacgag gtaaaaaaat gaatagagat gtattagagt ttctgagaac
    17701 agagaccgct gaaaaaatta gtctttatat aagcgaggct aatagattgg agggcgatgt
    17761 aactctactc gcacctagtt ctcaagattt ggaagatatt aaaaatgcta tgctttccaa
    17821 ttctaatctc ggattaaaag ttgcgagact ggatgtgatg aagaaaatag catatgcttc
    17881 tacaagaaat cattatttaa caggggctac gatttttggg gatatttcga aaggaacata
    17941 caattgtgat cctaaaagtt atgtctaata taagggaggt taatccctcc ccttgttttt
    18001 gaaaatcgaa aggaaaagta taaaaatgaa agttaatgaa tatttctgga gaacgagctg
    18061 tcttatacta aaaaagaaga aatcgataaa atagtatacg tgttagagat gtgtttgtcg
    18121 taaaagtctg gatagttttc tcctaggtag tcagctgtca tataataaaa agtagaatgg
    18181 caagcagtga taattggcat aagagatgaa aaacgctgag aactaatgaa ggctaagaga
    18241 acaaaaaata gaaaatcaat ggtgagaacc cctaaatagt agaagcgaat ctttttattg
    18301 atttgaggat aaatctcagc gaattgatgt ttgagtcgga cgaccaagag aaatagcagg
    18361 agtccttgag caaggaagaa aattaaacca gagagcaaga gccactcaaa agatgtctcg
    18421 agtctagtga taaaaaatgc aaatagtagc aaatcaataa ctgcaattgc tataaaatgg
    18481 attctataga gttttttcat gacaagacct tcctctttta tctaacttca ttctactcca
    18541 aaagaatggg agttacaact aaaatgataa aaatagcaga agggagattc tcttaagttg
    18601 gctagtattc tttatttgag tttccttcta tgtatctaac ttcttcatca ttccagacaa
    18661 ataaagctcc gattgcattg aggatataaa agatgtattt accgatattg gcgaagtttc
    18721 cttgaatacc agcttttgtc agctgaacga aattgtaaat caaccaaaag ccccactgag
    18781 ttgttagttt caatgcattc aaagcattgg caatgaggga cagtgcaaag gcaatagttg
    18841 ttacgtaggc aaggagattc atcttgccct catatccgat atagttggtc acaaaggcaa
    18901 agaggaaggc gatgatggaa atgatgatgg ccgccaattt tacctgtttt tggctcattt
    18961 ggttgggtct gccttcttgc gaagctttcc atttctttat agcaaaggta taaatgagga
    19021 aggtgacggg ataggtaatg atggccgcct tatttccaag gatataatca atagcaccgg
    19081 acaaaatggt attaacaata ccaaagtaat ttccccattt gcttaatttc cccgtgaaac
    19141 gagtggacaa catggaaatc ccaacgttgg ttacggaaat caatccaaag ggtacaagag
    19201 ctgtccatgg tccccagtct acaaatttat cgaggcgtga gttgaggtaa ccagatgcaa
    19261 tcgcaatcca acgaccaaag caaccccgaa gaggtcaaac tatttagatg tagcaaaaat
    19321 ttttagtgat tttttcatag gttaaactac ctttcttttt ttcaaatatt ctcccaccaa
    19381 atgaaagtaa aataaaatga tagaaataaa accctgaaaa taaaactttc agggttggta
    19441 ggggacttga gaaattagtt gattttctcg acatagagtt gttttgcaat gtccatattc
    19501 acttgtaaat cctcgtcgtt actgaggata gtgaaggtat tgctgaagcc atcaaactgc
    19561 ttgacttgga gctggtcacc gatgtgaagt gagtgcttgt ccagataatg gagaatgtca
    19621 aaactatcgt gcacccgagt caggcggtag gcgccagctt ccttgatatc agctagtggg
    19681 aggttattga tttcaacgag gagttctccc ttggcaggaa tagttcctcc gtgggggcag
    19741 gttttaggga aacctagcag tttatctagt ctttccacga acaggtcaga gacagtgtgt
    19801 tccaagacct cagcttcctc gtgaatctgg tcacttgtat agtctaaatg atgaactaga
    19861 aaaacttcaa tcaagcggtg cttacgatag agctcagaga ccagtttgag accgaggtca
    19921 gtcagtagat agccacattc cttgtccttt aggatgagat tttcactttt cattcgtttg
    19981 atcatttcag ttacggcagg gggagagact tgcatgcgag ccgcaatttc cttgttggta
    20041 atcttatgca ggtctatgcc aatttcataa atacatttta gatagtcttc tttgtttggg
    20101 gtcattcgtt tcctcttgtc taatatcttt atctagtata tcaaaaaaag ctagatttct
    20161 ctagctgtga ctttttatgt tatacttatt gcaagagaaa aaacgaggag atggatatga
    20221 cgaaaatagc tcttctttca gatattcatg gaaataccac cgccttggag gctgttttgg
    20281 cagatgctca gcagctagga gtggatgaat actggctttt gggagatatt ctcatgccag
    20341 ggacaggacg tagaaggatt ttggacttgt tggatcaact accgattacg gctagagttt
    20401 tgggaaactg ggaagacagt ctttggcatg gtgtccgtaa ggaattggat agtactcgcc
    20461 ctagtcaacg ctatctcttg cgccagtgcc agtatgtttt agaggaaatt tccctagaag
    20521 aaattgaagt gctccacaat caacctcttc aaattcatcg tcagtttggg gatttgacag
    20581 tgggaattag ccatcatctg cctgataaga actgggggcg agagttgatt catactggca
    20641 aacaagagaa ttttgaccgc ttggtgactc atcctccctg tgatattgct gtttatggac
    20701 atattcacca gcagttgctt cgtcacggga ctggtgggca attgattgtc aatccgggtt
    20761 cgattggcca acctttcttt ttggacgctc agctacggaa ggacttgcgg gcccagtata
    20821 tgattttgga gtttgatggc aagggcctgg tagatatgga cttccgacgg gtagactacg
    20881 atgtggcagc tgaattgcag ctggctaaag acctgagact tccctatttt gaggtttact
    20941 atgaaagtct ggtcaatggg atccaccata ctcatcatca ggaatttttg agagaattgg
    21001 ctcagaaaga gggttgcgat cgggagttag acgactggtt gaaaagtggt aacgattgac
    21061 attacaacta aaaagggtat aataatagaa aaagaagagt agaggcaggg tagcctcgta
    21121 aaaaggagaa gaggatgcaa attccaagta gatttaccat tgcgactcat atgctgataa
    21181 tcattgccct cgaggggaag gaaagcaagg tgaccagtga ttttctggct gctagtgtcg
    21241 gggtcaatcc tgtcattatc agaaagatct tgtcccagtt gaagaaggca gagctgattt
    21301 cagtagcgcg tggaacgggc ggaacagaga ttgtcaagga ccttaaggat attagtcttt
    21361 tagatgttta tcaggcggtc gaatgtcttg gtaagacagg tcaactcttc agtttccatg
    21421 acaatccgaa tccaaattgc cctgtaggag ctcatattca tgatgttttg gatcaaaaat
    21481 tggagagaat tcagttgact atggaggcag aacttggtca gaccagtcta gaaaaagtcg
    21541 tggccgatgc agagagtcag atgaaggatt aagagggata aatgccctct ttttttcttt
    21601 ggataattat gataaaatgt agctattaaa ggagtaagaa atgtatctcg ttatagaaat
    21661 tgtattagcc tttatagtgt cattttggaa ggataataga agtttgtgga atccagtatt
    21721 atttttatta tccctcattt caagttattt ttatctatcc tacctttttt ataaaaatgg
    21781 atacgagaat gttcagttag ctttttatgt atttaccttt gtcttacttc cttttttgct
    21841 ttttctaagt ggcatctttt taatctataa tggggtcatt ttgttgaaac gagagggacg
    21901 ttccaagccc cattatctct caatgctctt tgatttttat tgactattag attctattta
    21961 aaaagactta gaatgcacat gaaagtatgt attctaggtc ttttgttttg tatacattta
    22021 attttcaaga gtattatcta tttttccatg catggtaacg agtatcaatc aataactggg
    22081 taaggcgacc caaggtttct ctttcttctg gagtgaggga ttgagcttgg acaaagagat
    22141 gatgaatgta ttcaagcgcc tttaaggaag ccaagtcatt gatagagcta ataccagcat
    22201 caagaatagt gccaaagaag aggtcgaagt agagctgaag ttcttcgtca gggactgtgg
    22261 ccacccattc tttaaaggtt gtgtctactt gccggctatc actgttggtc ttatccagtt
    22321 gaacgaagtg cttgtcctca atctgccaac taaaggtatc gtgctgggcg atgccaccca
    22381 gggcagtact ctgaacgatg atttggtgag caggaatttc cagcatcata ccgataatag
    22441 acccttgtgg aatgaatatc ttgcttctat ccattatcct ttgataaccc gcagtctgtg
    22501 tcaattcttg atggagacca ggtgcatcaa atgtataaac tgctgtgatc tgattttgca
    22561 aactttgctc aatttggcta gcagcataga tagcgagatt tcctcccttg gaatgcccag
    22621 ccagaataac cttttgctta ggatgatggg caaaaaagtt ctttaaatag cgaagggcgt
    22681 gcttttgagc aggaatttcc ttcatatagg tcaggtggaa atcttccttc cagccaatga
    22741 tactgtcatc tgtcccacga aagacaatca gataggtatc gaggctgaca cgataagtca
    22801 tagccgcaaa ttgcttttgc agttcagggt cgatgtcgtt gataaaatgg gagagtttgc
    22861 aatttttgaa gcgcttgtgt tgagccaatt catctaataa ttgaaggcga tttttgctag
    22921 taagcatggt gggctctctt ggaacctgag gtgctagatc taaaagacgt tgaggaagtg
    22981 tggagaccag attatcaaag gagaggtagg tgatttctat taaggttaga atgtctaact
    23041 cattcaaggg aaggtcgtaa taagaatcat atgcgacatc tttcagatag tcaaaaatat
    23101 tggccataag agctcctttc tttttattta tcttagcaaa tttccctcaa attagctagt
    23161 agcatagcct gtttgtactg gctaaaaaca ggctatttca aattcagttt cagaccatct
    23221 agcatggaaa aatctgttat aataatggaa aaggagaagc gcatgcacaa gattttatta
    23281 atagaagatg atcaggtcat tcgtcaacag attgggaaaa tgctctctga atggggattt
    23341 gaagtggtcc tggtagaaga ctttatggaa gttttgagtc tatttgttca gtcggaacct
    23401 catctggtcc tcatggatat tggtttgccc ttgtttaatg gttatcactg gtgtcaggaa
    23461 atccgcaaga tttccaaggt acctatcatg tttctttctt cgagagacca ggctatggat
    23521 attgtcatgg caatcaatat gggggcggat gactttgtga ccaagccttt tgaccagcag
    23581 gttcttttag ctaaggttca gggcttgttg cgtcgttcct atgagtttgg gcgtgatgag
    23641 agtttgctgg aatatgctgg tgttatcctc aataccaaat ccatggattt acattatcaa
    23701 gggcaagtct tgaatttgac caagaatgaa ttccagattt tacgcgtgtt atttgagcat
    23761 gcaggcaaca tcgtagcacg tgacgacctg atgcgggaac tttggaacag tgactttttc
    23821 attgatgata ataccctctc tgtcaatgtg gctcgtttgc gtaaaaagtt ggaggagcag
    23881 ggattggtag gatttatcga gaccaagaaa ggaatagggt acggattgaa gcatgcttga
    23941 ttggaaacaa ttttttctag cctatctgcg ctcccgtagt cgtcttttta tctatctgct
    24001 ttttttggca tttcttgtct tactctttca gtttttattt gccagtctag gaatttactt
    24061 cctctacttt ttcttcttgt gttgctttgt aaccatctta tttttcactt gggacatatt
    24121 ggtggaaacg caggtctatc gccaggaact tctctatgga gagagggaag ccaagtctcc
    24181 tttggaaata gctttagcag aaaaattaga agcgcgtgag atggaactct atcagcagag
    24241 gtcaaaagca gaaagaaaac tgacggattt gctggattac tataccttgt gggttcatca
    24301 gataaagacc cccattgcag ccagtcaact cttagttgca gaagtggtcg accgccaact
    24361 gaagcagcag ctagaacagg aaattttcaa aatcgactcc tataccaacc tagttttaca
    24421 gtacctgcgt ttagaaagtt tccatgatga tttggtctta aagcaggttc aaattgagga
    24481 cttggtcaag gaaataattc gtaaatatgc tcttttcttt attcaaaaag gcttaaatgt
    24541 caatctacat gaccttgata aagaaatcgt gacggataaa aagtggctgc tagtggttat
    24601 tgagcaaatc atctcaaaca gtctcaagta caccaaggaa ggtggtctgg agatttatat
    24661 ggatgaccaa gagctttgta tcaaagatac gggaatcggg ataaaaaaca gtgatgtcct
    24721 ccgagtattt gaacgtggct tttcaggata caatggccgt ttgacccagc agtcctctgg
    24781 acttggcctt tatctatcta agaaaatttc tgaagaactg gggcaccaga ttcgtatcga
    24841 gtctgaggtc ggaaaaggaa cgacagtgcg gattcagttt gctcaagtga acttagtcct
    24901 tgagtaaaaa tagatgagaa aaagcctcca gattggaggc ttttatgcta gactcttatt
    24961 tctcaacgcg tgatttgttg gcgatatcag ctaggatagc ttgaacaaaa ttatcaactg
    25021 agacagtttg tgtttctttt tggccgtagc gacgaacgtt gactgtttcg tcttccattt
    25081 ctttgtctcc aacaattaat tggtaaggaa tcttgctggt ttgtgaagca cggatcttga
    25141 actgcatttt ttcattgcgc tcatctacgt ctgcacggac accgcggtca cggagtttct
    25201 tggccacttc ccaagcgtag ttcacgtgtt tttcgttaga tactgggatg agggttactt
    25261 ggtgtggtgc cagccatgtt gggaaggccc ccttgtagtt ctcaatcaag atagctgtga
    25321 agcgttccat agttgagata accccacggt ggatcatgac tggacggtga tcttcgccat
    25381 cagctccgat gtatttgagg tcgaagcgtt ctggcaacaa gaaatcaagt tggatagtag
    25441 aaagggtttc ttcttttcca agggcagttt taatctggat atccaatttt ggtccgtaga
    25501 aggctgcttc accttcggct tcaaagtagt ccacgcccat ttcatcaaga gctgcacgaa
    25561 gcatggtttg ggcattttcc cacatctcat cgttatcaaa gtacttatga gtatcttgag
    25621 ggtcacgaag agagaggcgg aagcggtagt cagtcaagtt gaagtcttca taaacatcga
    25681 taatcaactg aagggcacgt tggaattctt cttggatttg ttctggagta acgaataggt
    25741 gaccgtcgtt gagtgacatt tcacgtacac gttgaaggcc agtgagggca ccagattttt
    25801 cgtaacggtg catcataccg atttcagcga tacggattgg caattcacgg taagagtgaa
    25861 catggtgttt gaaaacttgg atgtggtgcg gacagttcat tggacgaagg acaaattctt
    25921 ccccgtcacc catgtccatg gttgggaaca tgtcttcttg gtaatgatcc cagtgaccag
    25981 aagtcttgta aagctcaaca gaagcaagtg gtggagtgta gacgtgttgg tagccagaag
    26041 ccaactcttt gtttacgatg tagcgttcca attcacgacg gatagtcgca ccatttggca
    26101 accagaatgg caaaccttgt cccacttctt gtgaaatcat aaagaggtca agctctttac
    26161 caagtttacg gtggtcacgt tccttagctt cttcacgcat ttgaaggtag tttttcaagt
    26221 ctttcttgtc aaaccaagct gtaccgtaga tacgttgcat catagcgttg tcgctgtttc
    26281 cacgccagta agcaccagct acatggagaa ggtggaagat ttggatacga cctgttgatg
    26341 gaacgtgagg tccacggcag aggtctacat attcaccctg acgatagata gtcaaaccgc
    26401 cttcgtcttc tgagtgttct tcaatcaatt ccaacttgta agggtcattt ttgaagattt
    26461 cacgtgcctc gtctttagtc acttcttcac gaatagatgg gaagttttct ttgacgattt
    26521 tttgcatttc ttcttcgata cgaggaaggt cttcgttaga gatttgacca gctatgttgt
    26581 cagtatcgta gtagaaacca tcttcgatgg ctggaccaac tcccaagtga atgtctggga
    26641 aaagacgacg agctgcttgg gcgaacaagt gagctgctga gtgacgcaag attggaaggg
    26701 catcttcgtg atcaggtgtc acaatttcga tgcttccatc ttcagtgata gcgcgagtag
    26761 tgtcgatgag tttgccgttg aatttaccag ccaaggcttt tttagctagg gaattgctga
    26821 tagattgggc aatttcaaaa gttgttacgc cagattcgaa ttcacgaaca gcgccatctg
    26881 ggaaagtaat gttaatcatg atgttctcct tttttattat ttcatagttt ctaagcattg
    26941 attttttatc agcagactac ttccaagtcc taacgttcaa ttgcttttct ttatcagaga
    27001 ggaagttttc catttccgtc agaatgtcta tatccaaacg ttgagaaagt tctaatagcc
    27061 accagatatt ttctgaaagt ttttgttcca gtgtgtaggg tgtttcatca tagtagcgtc
    27121 cttgctttgt catcaccaat cgttggaaat ttccaatatc attagataaa gccaagaggt
    27181 cttcttctac cgtccacttg gaatcatgat gcttaacttc cagttcgtga taagcttgtc
    27241 ggattgccca actgtgctcc actaattctt gcaactccat aattagtatc ctaataaaaa
    27301 aatgcgacat cctcgaaagg acgtcgcaac gtggttccac cttcatttat atacctcaaa
    27361 agagagggac acctctgatc ggctctaacg tggccaccgt tttatgtttt cataaaaaac
    27421 tcaagagtag tatcagttta gacttcctat gcgtttccag caaccacgca ctctctagta
    27481 gaaagggact aagtgacttg tctctatgga ttattatagc atgattgtga gatttttcaa
    27541 ggattttgtg aaagtttttt gtttttcatt ttttgtagaa tatgcttgat gctaatacca
    27601 gaatccatgc tcaccagagc aactgtttca tagattagca agtaaattag tataaactca
    27661 ccaaagatta tgatagtgaa gtaaaagagc agtccgttac caactaacca tcaaagtgag
    27721 aaacggaaac ggtagctata gagtaacgat acaatcaaga ttaccagagg tgtaaagaag
    27781 agaagattgt ttatatagag tcccttgagt gtaagggggt cagaaacaac tagcaagaac
    27841 aactcataaa gtggccaata aatatgacca gatagtaggg gagatgggaa tagaatctac
    27901 gcatgataat cacctcgttt taaaaaaaac agacaactta gatctcttgc tatgattatt
    27961 ataagcatgt ttaaaacaag aaagtaaatt tgttgacaaa gaagattttt cttttcacta
    28021 gaatcatagt tagttttctt ggtagaaata ttttgataat aattaagcaa gactattgac
    28081 attgattatt aagagtgtca caattgctgt aactaaaata attacaacaa gagaggtata
    28141 aaaaatgaaa ctagcagtta ttgcagcaaa tggacaagtg gggaaagcaa ttgttgaaga
    28201 agcagtcaaa cgaggacatg aagtaacggc tattgttcgt tctgaaaaca aaagtcaagc
    28261 tgagtctatt attaaaaaag atttatttga gttgacaaaa gatgatctta ctggatttga
    28321 tgctgttatt tcagcgtttg gtgcttatac accagatacg ctaccgctcc atagcaaatc
    28381 aatcgaacta tttaatcagc ttcttgctgg aacacagaca cgttttctag ttgtaggggg
    28441 agcagaaagt ctttatatag atgaaacaaa aacgacacga cttttagata cgtctgattt
    28501 tcctgaagaa tttaagtcac tagcaaaagc tcaagcggat gaattggatc ttcttcgtac
    28561 aaaaaataat ctcaactgga cttttgtcag tcctgctgta gattttattc ccgatggtga
    28621 aaaaacagga aactacattc tagcaggaga aatttttact actaatgaaa aaaggaataa
    28681 gccagattag ttatgcagat tatgctattg gattggtaga tgaacttgaa aaaggtcatc
    28741 atataaaaga acgtatctct ttacttgaaa aataataact atgagagtat taatgtttga
    28801 cagaaaattt aaatcttggt aaaataggga ttgtcgtaaa gacaaataac ttcttcttgg
    28861 ttacaggcat gccaacctgt cactcggatg aagccaaata aaaaggagaa acatcatggc
    28921 aatctcaaaa gagaaaaaaa atgaaatcat tgcacaatat gcacgtcacg aaggtgatac
    28981 aggttcagta gaggttcaag ttgctgtcct tacttgggaa atcaaccacc ttaacgaaca
    29041 catcaaacaa cacaaaaaag accacgctac ttaccgtgga ttgatgaaaa aaatcggtcg
    29101 tcgtcgtaac ttgcttgcat acttgcgtaa aaacgacgtt aaccgttacc gtgagttgat
    29161 caactctcta ggacttcgtc gctaattcaa gatacaaagg ccgtcaaaag cacaaagcaa
    29221 aaataggaaa attgacgaag aaacttcagt ttctaggaga ttttatcttt tttgccaagt
    29281 gcttaggccg tgttcaattg agcatatctt gataataaag ctactctaaa ttgggtagct
    29341 tttttgcgtt gtcaccttac ctcgctatac tcaagtataa tctttggtta cggttcctag
    29401 cactgtaagg taaaataaac cagcttttct cccttcgggg agattttttt tgtttcactg
    29461 aaagtttcgt acgatcttcg cctcgtcgcc tagtctataa acgatttatc tagcaagaat
    29521 catgatgcta agggcgtcaa aaatccgtat gaaaataggg aaatgacaca gtgttcgatg
    29581 agcacaagga gtttcatctt tttcactagg attttagccc gggctaaaat cagctctctg
    29641 acttcagagg gcttttttat tgaggtttta tcggtaacaa ttttggagac tacaaaaacc
    29701 tcaaatggta tcagctaatt acaccataaa ggtgcgcagt tactcggctt ttcaagccga
    29761 gtagctgtat gcaagccccc tagaagagcc cactctttac aaagtaaagt atagtatgtt
    29821 atactttaca tggaagtagt cactgaattc cagttagaaa ttactttgta actacgtttt
    29881 gaggaggagt aaaatgcttt cctacgttcg acattaccca ctagcgatag ctaaattaat
    29941 gtgtctgtgc tctcctgaaa tctgctgatt tattactgac taatacagga ggtttttttt
    30001 atgggacaga caatcatatc tgctattggt gtttatattt ccaccagtat cgattattta
    30061 attattttaa ttattttatt tgcacagcta tcacagaata aacagaaatg gcatatttat
    30121 gcggggcaat atctaggcac aggcttactt gtaggggcga gtttagttgc tgcttatgtc
    30181 gttaatttcg tgcctgaaga atggatggtt ggattgcttg gtttaatccc tatctattta
    30241 gggattcgct ttgcaattgt tggagaagat gcggaagaag aagaggaaga aattattgaa
    30301 agattagaac aaagcaaggc aaatcaactg ttttggacag ttacattgct gacaattgcg
    30361 tctggcggag ataatttagg tatctatata ccttattttg cttcgttaga ttggtcacag
    30421 accctcgtgg ccttgcttgt gtttgtaatc ggcataatta tcttttgcga gattagtcgg
    30481 gtgttatcct ctattccgtt aatattcgag acaattgaaa aatacgagcg aatcattgtg
    30541 cccttagtat tcattctact tggactatac atcatgtatg aaaatggcac gatagagact
    30601 tttctgatcg tgtagatttt tttgtttcac taggatttta gcccgagctc aaatcagctc
    30661 tctgattttc agagggcttt ttcattgagt ataaatggac aatcttaaag ttactctatt
    30721 gtagagtggc ttttgatttg attaggagat tcttataaat atagtaaaat gaaacaaaaa
    30781 caggacaaat cgatcaggac agtcaaatcg atttctaaaa atgttttaag aagtagaggt
    30841 gtactattct agtttcaatt tgctatataa atgaaaacct tagctgtttg gccaaggttc
    30901 atttcttcta tgcaagttct tctcttttct tatctgggtt ccagatgaag cttgcgataa
    30961 agctaaagat gatggttagg atagcgagga taatagcaag gatgagggca gggatgcgga
    31021 taaaccacca gagtggattt ggttttttat cattgtgcca ttgtttcgtt tcttcgtcca
    31081 gacgttggaa ttctgtttga atacgattgg cgactgtttc aatgccttca tcattcattt
    31141 tcttgatatc tgagatatcg attggatttc caaagttcat atcgacacgt tcacggctaa
    31201 tcaagccctt caaaatcatg ggaccggtgt aggtaaccgg catgatacgg accttggcca
    31261 ttttggcaat cagtgctgcg ccccccttga catcgtttga gtggcggcta ccacttggaa
    31321 acatgatgag agagcggtca ctttttttga gaacgttgat aggatatttg atggctgagg
    31381 cgctgggatt ttcacggtcg atgggaaagg cgccacacat acgaatccac caaccaaaga
    31441 tacggttggt aaagagttct ttttttgcca taaagatgaa ctgttttggc ttggtcgcaa
    31501 aggccatata aacaggatcc caccaggtac ggtgaggcgc aactaaaata taattttcat
    31561 cttgattagg aattttatca gtattatgat agtgagcatt gccattgatg gaccataaga
    31621 gcaacacaac taatccacgc aaataagtat aaaacatgcg atctccttcg attgttttct
    31681 tgttattatt ataccttatc aaaggagggc tggcaaactt ttcccttgac tagatgcata
    31741 tttgggatga aattagaatt ctgttaaaaa aaatggtata atagaattta tggataaaaa
    31801 taagattatg ggattaaccc aaagagaagt caaggaaaga caggctgagg gtttggtcaa
    31861 tgactttacc gcatcagcca gtaccagcac ttggcaaatc gttaaacgaa atgtctttac
    31921 cctttttaac gctttgaact ttgccattgc tttggccctt gcctttgtgc aggcttggag
    31981 caatctggtc ttctttgctg ttatctgctt taacgctttt tctgggattg tgaccgagct
    32041 acgagccaaa cacatggtgg acaagctcaa tctcatgacc aaggaaaagg tcaaaaccat
    32101 ccgtgatggt caggaagttg ctcttaatcc tgaagaatta gtgctaggag atgtcattcg
    32161 tttgtctgca ggagagcaga ttcctagtga tgccttggtt ttggaaggct ttgcggaagt
    32221 caatgaagcc atgttaacgg gagaaagtga tttggtgcaa aaggaagttg acggcttact
    32281 tttgtcagga agtttcctag ccagtgggtc agttttatct caagttcacc atgtcggtgc
    32341 agacaactat gctgccaaac tcatgcttga ggctaagacc gttaaaccca tcaactcccg
    32401 tatcatgaaa tcgctggaca agttggctgg ttttactggg aagattatca ttccctttgg
    32461 tctggctctc ttgctggaag ccttgctttt aaaaggcctg cctctcaagt catccgttgt
    32521 aaactcgtcg acagctcttt tgggaatgtt gcctaaggga attgcccttt tgaccattac
    32581 ttcgctcttg actgcagtga ttaagttggg cttgaaaaag gtcttggtgc aggagatgta
    32641 ctctgttgag accttggcgc gcgtggatat gctctgtctg gacaagacgg gcaccatcac
    32701 ccaaggaaag atgcaggtgg aggctgttct tccactgacg gaaacttacg gtgaagaggc
    32761 tattgccagc atcttgacta gctacatggc ccatagtgag gataagaatc caactgccca
    32821 agccattcgc cagcgttttg tgggagatgt tgcttatcct atgatttcca atcttccctt
    32881 ctcgagcgac cgcaagtggg gggctatgga gttagaaggc ttggggacag ttttcttagg
    32941 ggcacctgag atgttgctgg attctgaagt cccagaagcc agggaggcct tggagagagg
    33001 atcacgtgtc ttggtcttag ctctcagtca ggagaaatta gaccatcaca aaccacagaa
    33061 accatctgat attcaggctc tagccttgct ggaaatcttg gaccccattc gagagggagc
    33121 agcagagacg ctggactatc tccgttctca ggaggtggga ctcaagatta tctctggtga
    33181 caatccagtt acggtgtcca gcattgccca gaaggctggt tttgcggact atcacagcta
    33241 tgtagattgc tcaaaaatca ccgatgagga attgatggcc atggcggagg agacagctat
    33301 tttcggacgt gtttcccctc atcaaaagaa actcatcatc caaacgttga aaaaagcggg
    33361 tcatacaacg gctatgacag gggacggggt taatgatatc ttggcccttc gtgaggcgga
    33421 ttgttctatc gtgatggcgg agggggatcc agcaacccgt cagattgcca atctggttct
    33481 cttgaactca gactttaatg atgttcctga gattctcttc gagggtcgtc gcgtggtcaa
    33541 taacattgcc cacatcgccc cgattttctt gataaagacc atctattcct tcctgttagc
    33601 agtcatctgt attgccagtg ctttactagg tcggtcagag tggattttga ttttcccctt
    33661 cattccgatc cagattacca tgattgacca gtttgtggaa ggtttcccac cattcgttct
    33721 gacttttgag cgaaatatca aacctgttga gccaaatttc ctcagaaaat ccatgcttcg
    33781 tgccctacca agcgctctca tggtcgtctt cagcgtcctg tttgtgaaaa tatttgggag
    33841 tagccaaggt tggtctgagt tagaaatctc aactctactc tattatctct tggggtcaat
    33901 tggtttctta tccgtattta gagcctgcat gccatttacc ctatggcgtg tcctcttgat
    33961 tgtttggtca gtaggaggtt tcctagccac agctctcttc ccaagaattc aaaaactgct
    34021 tgaaatttca accttaacag gacaaacatt acctgtttat ggtgtcatga tgttggtctt
    34081 taccgtgatt ttcatcctga ccagtcgtta ccaagcgaaa aaataaagaa agactgcaat
    34141 ctgtggattg cggttttttt aggtacaaga ttgccagccg aaatgtggta taataagagg
    34201 taatagagtt tggaaagtga gagaaaatga tttcaaagag attagaattg gtagcttcct
    34261 ttgtgtcaca gggggctatt ttactagatg tgggaagtga ccatgcttat ctgcctatcg
    34321 agttggttga gagaggccaa atcaaaagcg ctattgcagg tgaggtggtg gaaggtccct
    34381 atcagtctgc ggttaaaaat gttgaggctc acggcctaaa ggagaaaatc caagtccgtt
    34441 tagccaatgg cttggcagct tttgaagaga ctgaccaagt gtctgtcatt accattgctg
    34501 gcatgggtgg tcgtttgatt gctaggattt tagaagaagg tttggggaag ttagctaatg
    34561 tagagcgttt gatcctccag cccaataatc gtgaagacga cttgcgtatc tggctacagg
    34621 atcatggatt ccagattgta gcagaaagca tcttagaaga agctggaaag ttttatgaga
    34681 ttttggtggt ggaagcagga caaatgaagc tatcagccag tgatgttcgc tttggtccct
    34741 tcttgtccaa agaagtcagt ccagtatttg tccaaaaatg gcaaaaagaa gctgagaagc
    34801 tagagttcgc cctcggacaa atcccagaaa aaaatctgga agaacgtcaa gttctagtag
    34861 ataagattca agctatcaag gaggtgcccc atgttagcaa gtgaagtgat ccaagcttat
    34921 gaagcctttt gccctcagga attttctatg gagggagaca gccgtggtct gcaaattggc
    34981 actttagaca agggtatcca aagggtcatg gttgccctcg atattcgtga agagacagtg
    35041 gcagaggcca ttgaaaaggg tgtggacttg attatcgtca agcacgcgcc tatctttcgt
    35101 cctatcaagg acttgcttgc cagccgtccg caaaatcaga tttacatcga cctgattaag
    35161 catgatatcg cagtttatgt cagccatacc aatattgata tcgttgaaaa tgggctcaat
    35221 gactggtttt gtcagatgct aggaatcgag gagacgactt atctgcagga aacaggtcca
    35281 gaacgtggaa ttggacgtat tgggaatatt cagcctcaga cattttggga attggcccaa
    35341 caggtcaagc aagtctttga cctagatagc cttcgaatgg tgcattatca agagaatgat
    35401 ttgcagaagc ctatttcaag agtagcaatt tgtggtggaa gcgggcagtc tttctataag
    35461 gatgctttgg caaagggggc agatgtctat atcactggtg atatctacta ccatactgct
    35521 caggatatgc tgtctgatgg cttgttagca ttggatccag gtcactatat cgaagtgctt
    35581 tttgtggaaa aaatcgcagc actccttact caatggaaag agaaaaaagg ctgggaacta
    35641 gagattttac ctagtcaagc atcgaccaat cctttccgtc atatctagtt agaaagtgaa
    35701 gacaatgaaa aaagttgcca ttattggagc aggaattgtg ggagcaacag ctgcctacta
    35761 cctctcgaga gaaagtgacc tagaggtgac cgtttttgac catgagcaag gtcaagccac
    35821 caaggccgca gcaggaatta tcagtccttg gctttcaaaa cgccgcaata aggcctggta
    35881 caagatggcg cgattggggg ctgactttta tgtggattta ttagctgatt tagagaaatc
    35941 aggacaagaa atcgactttt accagcgttc gggagtcttt ctcttgaaaa aggatgaatc
    36001 caagttggaa gaactctatc aactggctct ccagcgcaga gaagaatctc ccttgatagg
    36061 ccagttatcc attctggacc aagccccagc taatgaatta ttccctggct tgcagggatt
    36121 cgacaacttg ctctatgctt ctggtggagc gagagtagat ggtcacctct tagtaactcg
    36181 tttgctggaa gccagtcagg tcaagttggt caaagaaaaa gtgactctga cactcttatc
    36241 atcaggctac cagattggcg aagaggtgtt tgatcaggtt attttggcaa cgggagcttg
    36301 gttgggggac atgttagagc ctttaggtta tgaagtggat gtccgtcctc aaaaaggaca
    36361 actacgagat tatcagcttg cccaagacat ggaagattac cctgttgtca tgccagaagg
    36421 ggagtgggat ttgattccct ttgcaggtgg gaaattatcc ttgggcgcta cccatgaaaa
    36481 tgacatggga tttgatttga cggtagatga acccttgctc caacaaatgg aggaggcggc
    36541 cttgcctcat tacccagttt tagctagagt gacttcaagg gctgagcgtg tgggaatccg
    36601 tgcctatacc agtgatttct ctcccttctt tgggcaggtg ccagaattgg caggtgtcta
    36661 tgcagccagt ggactaggtt catcaggcct cacaactggt cctatcattg gttaccatct
    36721 agcccaactg atccaagaca aggagttgac cttggaccct gaaaactacc caattgaaaa
    36781 ctatgtcaaa cgagtaaaaa gcgaataata ctcaatgaaa atcaaagaac aaactaggaa
    36841 actagccgcg gattactcaa agcactgctt tgaggttgtg gatagaactg acgaagtcag
    36901 ctcaaaacac tgttttgagg ttgtggatag aactgacgaa gtcagtaacc atacccatgg
    36961 caaggcgacg ttgacgtggt ttgaattgga ttttcgaaga gtataagcat tttactgaaa
    37021 ttttatcagg tagtttagga tggcaaatga cattccctgt caaaaatggt aaaataagaa
    37081 aaaataatct gagaatcgag gaaaaaagat gcaagaaaag attttggtaa ctggtggtgc
    37141 cggttttatt ggaacccaca ctgttattga attgatccaa gcaggccatc aagttgttgt
    37201 ggtggataat cttgtcaata gcaatcgtaa gagtttagaa gttgttgaaa gaatcacagg
    37261 agttgagatt cctttctatg aggcagatat tcgtgacaca gataccctca gagatatttt
    37321 caagcaggaa gaaccgactg gtatcattca ctttgctggt ttgaaggctg ttggcgaatc
    37381 aacacgtatc cctcttgcct actatgacaa caatatcgct ggaactgtca gccttttgaa
    37441 agccatggaa gaaaacaact gtaaaaacat catcttcagt tcttctgcga cagtttacgg
    37501 ggatccgcac acagtgccca tcttggaaga tttcccactt tcagtgacca acccatacgg
    37561 tcgtactaag ctcatgctag aggaaatttt gactgatatt tacaaagcag actcagaatg
    37621 gaatgttgtc ttgcttcgtt actttaaccc aatcggagcc catgagagtg gtgatttggg
    37681 agaaaatcca aacggtattc caaacaatct cttgccatat gtgactcaag tagccgttgg
    37741 aaaattagag caagtgcaag tgtttggaga cgattacgat acggaagatg gaacaggtgt
    37801 tcgtgattat atccacgttg tcgatttggc taagggtcac gttgcagctt tgaaaaaaat
    37861 ccaaaaaggt tcaggactaa acgtttataa ccttggaact ggtaaaggtt actcagttct
    37921 tgaaattatc caaaacatgg aaaaagcggt gggacgtcct attccttacc gcatcgtaga
    37981 acgtcgccca ggtgatatcg ctgcctgcta ctcagaccca gcaaaagcta aagcagaact
    38041 cggttgggaa gcagaactcg acatcaccca aatgtgtgaa gacgcatggc gttggcaaag
    38101 caagcatcca aatggatttg aagactaaga tgatgatttc aatcatcgtc ccttgtttaa
    38161 acgaagagga agtacttcct cttttttatc aggctctgga agctttactt ccagatttgg
    38221 aaacagaaat cgagtatgtc tttgtcgatg atggatcaag tgatgggacc ttggaactct
    38281 taaaggccta tcgggagcaa aatccggcag tccattatat ttctttctct cgaaattttg
    38341 gcaaagaagc agccctttat gcaggcttgc aatatgcgac aggagatttg gtggtggtga
    38401 tggatgcaga cctccaagat cctcctagta tgttgtttga gatgaaaaat gtactagaca
    38461 aaaatgtaga cttggactgc gttgggacac ggagaactag tcgggaggga gaacccttct
    38521 ttcgcagttt ctgtgctgtt ctcttttatc gcctcatgca aaaaatcagc ccagtagctc
    38581 tgccgtcggg tgtccgtgat tttcgtatga tgagaaggtc tgtagtcgat gccattttaa
    38641 gcttgaccga gtccaatcgt ttttcaaagg ggctcttcgc ctgggtgggt ttcaaaacct
    38701 actatttgga ctatccaaat gtcgaaaggc aggctggcaa gacaagttgg agttttaggc
    38761 aactcttttt ctactccatt gaagggatta ttaatttttc agattttccc ttgattatag
    38821 cctttgtagc tggtctccta tcttgttttc tttctctgct gatgaccttt tttgttgtgg
    38881 ttcggaccct cattttgggc aatccgacat ctggttggac ctctctgatg gctgttattc
    38941 tctttcttgg aggcattcaa ctcttgacca ttgggattct cggcaagtat atcagtaaga
    39001 tttatttaga gactaaaaaa agaccacttt atcttatcaa agaaaaaagt gaccttcctg
    39061 attttacaga aaaaaataaa gtgaaaagac tataatttta catggaaatg tgctaaacta
    39121 gagggagtgg attatcgcca ttgatttagg cttcctggtt tccaatcagg gcgcgagttg
    39181 ggcaattttt aacagcctct aagacatcct gactaggaga aatttctttt tccagttggt
    39241 cagggtcatc gtaaaaacgc acgattccat tatcgtggta atcaaataaa tcagaataag
    39301 tttggcaaag cccacaggcg atacatcgtt caggtataag tgtgattttc atgttcatat
    39361 ttatattgta ataagaaaag taaaaaaaaa caaggagtaa ggtatggcaa aagaaccgtg
    39421 gcaagaagat atctatgatc aagaagaatc aagagcagag cgtcggcatc gaaaccacgg
    39481 aggggctgat aggatggcta atcgtatttt gacgatccta gctagtattt tctttgtaat
    39541 tgtggtggtg atggtcatcg ttctcatcta tctatcatcg gggggaagta atcgcacagc
    39601 agccttaaaa gactttcatg attctgatgc aagtgtagta caaatctcat cttcaagcag
    39661 ttctcagcct gagcagagtt cagagccaga atctacttct agtagttcag aagaagctgc
    39721 taatcctgaa ggaacgatta aagttctcgc aggagaaggg gaagcagcta ttgccgctcg
    39781 tgcaggaatc tccattgctc agttagaggc cttgaatcct gggcacatgg ctacaggatc
    39841 ttggtttgct aatccaggtg atgttataaa aataaaatag gagccgatat gaaaacaatt
    39901 caaattgcta ttgatggtcc tgcttccagc ggtaagagta cggtcgcaaa gattattgct
    39961 aaggattttg gattcaccta ccttgataca ggagctatgt atcgtgcagc gacctatatg
    40021 gctcttaaga accaattagg agttgaagaa gtcgaagccc ttctagcctt gttggaccag
    40081 catccaatca gctttggacg ttcagaaact ggagaccagc ttgtttttgt aggagatgtg
    40141 gatattaccc atcctatccg tgaaaatgaa gtgaccaatc atgtttctgc tattgcagca
    40201 attcctgaag tgcgtgagaa attggtttct ctccaacaag aaattgccca gcaaggcggg
    40261 attgtcatgg atggtcgcga tattggaact gttgtattgc cacaagcaga attgaaaatt
    40321 ttcctagtag cttctgttga tgagagagca gagcgtcgtt acaaggaaaa tattgccaag
    40381 ggaattgaaa cagaccttga aaccctaaaa aaggaaattg ctgcgcgtga ctacaaggat
    40441 agtcatcgtg agacttctcc tctcaaacaa gcagaggatg ctgtctacct tgatacaact
    40501 ggtttgaaca ttcaagaagt agttgaaaaa atcaaagcag aagctgaaaa aagaatgtaa
    40561 atgtagaaaa gccgatagat tgatatcggt tttttctaaa tttgtcaaaa tgctgatttt
    40621 agggtataat agttgctgtt cgagaaattt tgattttcaa agaatagtga atgatgataa
    40681 ggagaaatca tgaacaattt accaaattgt ccaaaatgta actcagagta tgtctacgaa
    40741 gacggtgccc tactggtttg cccagagtgt gctcatgagt ggaatcctgc tgaagttgca
    40801 gaagtagaag aaggtcttgt cgctatcgat gccaacggaa ataaattggc tgatggtgat
    40861 acagtaactc tcatcaagga cttgaaagta aaaggtgcgc caaaagattt gaaacaaggg
    40921 acgcgcgtga aaaatatcca catcgtagaa ggcgaccaca atatcgactg taagattgat
    40981 ggttttggtg ccatgaaact taaatcagag tttgtgagga agatttaagc atgtcaaaac
    41041 actataaact tgtattttat agccgtatct tcttgtttct agcggctttt acgggagttt
    41101 atcttgaaat tactaagcat ggtggttttg ggatgcttct ctattacacg gttctgtcca
    41161 acctcttggt aactattttt accctttatc ttctaaaggt tatgagccgt gtaggtgaaa
    41221 attggcaaag accaagtctc ttgcgcttaa aaggtggggt caccatgagt atcatgatta
    41281 cctgtgtgat ttaccatttc ctcttggcgc ccattgcgac taatttctat accctagaaa
    41341 atttcctttg ccactatatc gttcccatct ggtttttagc ggataccctc ttttttgaca
    41401 aacagggtca atacaagatt tgggatccag cagtgtggac cattttaccc tttctgtata
    41461 tgatgtttgc tctttttaat ggcttggttc taaaactcaa tattccaaat gccaaggata
    41521 atcctttccc ttacttcttt ttgaatgtga acaagggttg gaatgttgtg tttaagtggt
    41581 gtctgattat ctttgttgcc tatatggtag caggatttat tttctacttt atcaagcaaa
    41641 tcaagagaaa gtcatcctaa tactcttcga aaatctcttc aaaccacgtc agtttccatc
    41701 tgcaacctca aaacactgtt ttgaacaacc tgcggctagc ttcctagttt gctctttgat
    41761 tttcattgag tataagatac aagggattca ttttcgaatt taagaaggag tctacaaacc
    41821 aatgaggctt cttcttttct tgcttatttg ataactatca aaaaagtaga agattaagag
    41881 aaatatagaa agagatttca tgaaacaatt tttagaacgg gccagcattt tggctctctc
    41941 cctcgttttg attacctcct tttccatttc gagtgcccta ccagccatgt ttgactatta
    42001 tcagggttat tctaaggaac aaattgagct cttggtgagc ttgccttcct ttggaatcat
    42061 gatgatgtta ctgctaaatg gtttcttaga aaaaatattt cctgagcgct tacagattag
    42121 tttgggcttg ctgattttat cattgagcgg tacagctccc ttctggtacc aagcctatcc
    42181 ctttgtcttt ggagcacggc ttctctttgg tttgggtctt gggatgatca atgccaaggc
    42241 catttctatt atcagtgaac gctaccaagg aaaaaggcga attcagatgt tagggctacg
    42301 cgcttctgca gaggtcgttg gagcttctct cattaccttg gccgtcggtc agttgttggc
    42361 ctttggttgg acagctatct ttctagccta tagtgctgga tttttggtgc tgccccttta
    42421 tctgctcttt gtcccttatg gaaaatcaaa gaaagaagtc aagaaaagag cgaaggaagc
    42481 aagtcgttta actcgagaaa tgaaaggctt gatttttacc ttagctatcg aagcggcagt
    42541 tgtagtttgt accaatacag ctattaccat ccgtattcca agtttgatgg tggaaagagg
    42601 attgggggat gcccagttat ctagttttgt tcttagtatc atgcagttga tcgggattgt
    42661 ggctggggtg agtttttctt tcttgatttc tatctttaaa gagaaactgc tcctctggtc
    42721 tggtattacc tttggcttgg ggcaaattgt gattgccttg tcttcatcct tgtgggtggt
    42781 agtagcagga agtgttctgg ctggatttgc ctatagtgta gtcttgacga cggtctttca
    42841 acttgtctct gaacgaattc cagctaaact cctcaatcaa gcaacttcat ttgctgtatt
    42901 aggctgtagt ttcggagcct ttacgacccc atttgttcta ggtgcaattg gcttactaac
    42961 tcacaatggg atgttggtct ttagtatctt aggaggttgg ttgattgtaa tctctatctt
    43021 tgtcatgtac ctacttcaga agagagctta ggattgattc ctaagttttt cttttgatac
    43081 tcaatgaaaa tcaaagagca aactatagtt gattgagttt ggaatagtac gctgtagctg
    43141 ctaaaatatt tctagaaatt aatttgactt tcctaataga gttattcata tcttatttca
    43201 atctactata gaaagctagc cgcaggttgc tcaaaatagt gttttgaggt tgcagatgga
    43261 aactgacgtg gtttgaagag attttcgaag agtatgagat ttttataccc atacaatatt
    43321 tgttttaggt ccttgtttac agactaattt cttgataaaa tagaggttat gacgagatat
    43381 aaagcaacta tttcctatga tggttatgcc tttgctggct ttcagcgcca gtctcatgcg
    43441 cgtagcgttc aggaagaaat tgaaaaaacc ttgaccagat taaataaagg gcaagccatt
    43501 actgttcacg gtgctggtag gacagatagt ggggttcatg ccctgggaca ggtcattcat
    43561 tttgacctgc cttatcagat tgatgaggag aaactccgtt ttgccttgga tacccagtct
    43621 cctgaagata ttgatgtgat ttcgattgag cttgtggcag atgattttca ttgccgttat
    43681 gccaagcata gcaagaccta tgagtttatt gtggatagag gacgtcccaa aaatccgatg
    43741 cgccgtcact atgccaccca ctttccctac ccactcgatg tggaacgaat gcagattgca
    43801 atcaaaaagc tagagggaac ccatgatttt accggtttta cagcctctgg gactagtgta
    43861 gaggataagg ttcgcaccat cacagaagct agtttaatag tcgatgagac aggacaattt
    43921 ttgaccttta ccttttccgg aaatggtttc ttgtataaac agattcgcaa tatggtgggg
    43981 actcttctca aaatcggtaa caaccgcatg ccagtagagc agattgatct catcttggag
    44041 aagaaggaca ggcaacttgc aggtcccact gcagcaccaa atggtttgta tttaaaggag
    44101 attcgttatg aagaataatc gtattttagc actttctgga aatgatattt ttagtggtgg
    44161 tggactgtca gctgatttgg ctacctatac cttgaacggc ttgcatgggt ttgtagcagt
    44221 gacttgtttg acagccttga cagaaaaagg atttgaagtc tttccaactg atgataccat
    44281 ttttcaacat gaattagata gcttgcgtga tgtggaattt gggggaatta agattggtct
    44341 tctccctact gtcagtgtgg ctgagaaggc cttggacttt atcaaacaac gcccaggagt
    44401 acctgtggtg ttggatcctg tcttggtctg caaggaaacg catgatgtag ctgtcagtga
    44461 gctctgccaa gagttgattc gctttttccc ttatgtcagt gtgattacgc ctaatctccc
    44521 agaagcagaa ttattatccg gtcaggaaat taaaaccttg gaagacatga aaactgcagc
    44581 gcagaaattg catgatttag gagcgccagc agtcattatc aagggaggca atcgtcttag
    44641 tcaggacaag gctgtggatg tcttttatga tggacagacc tttactatcc tagaaaatcc
    44701 agttatccaa ggccaaaatg ctggtgcagg ttgtaccttt gcctctagca ttgccagtca
    44761 cttgattaaa ggtgataaac ttttgccagc agtagaaagc tctaaggctt tcgtttatcg
    44821 tgctattgca caagcagatc agtatggagt aagacaatat gaagcaaaca aaaacaacta
    44881 aaatcgccct tgtatcccta ttaaccgccc tttctgtggt tctaggttat ttcttaaaaa
    44941 tcccaacacc tacaggaatt ctaactcttt tagatgctgg tgtcttcttt gcggcctttt
    45001 actttggtag tcgtgaagga gcggtagtcg gaggactagc aagtttcttg attgacctct
    45061 tatcaggcta ccctcagtgg atgttcttta gcttggtcaa ccatggcttg cagggatttt
    45121 tcgcaggatt taaaggaaaa agtcagtggt taggccttat tttagcaact attgccatgg
    45181 taggaggcta cgccttgggt tctactttga tgaatggctg ggcagcagcc ctcccagaaa
    45241 ttctaccaaa tttcatgcaa aatatggtag ggatgattgt aggatttatt cttagtcaaa
    45301 gtatcaagaa gattaagtaa tactcttcga aaatctcttc aaaccacgtc agtttccatc
    45361 tgcaacctca aaacactgtt ttgagcagcc tgcggctagc tttctagtct gattttcatt
    45421 gagcataaag aggttgagta aaaagtcttt caaataagaa aaacgcatag tatcaggtgt
    45481 tgaatgaaca cctgatacta tgcgttttat tgtgggaaga ttttcctcat tttctagtga
    45541 aattgaactt tttctaacat cttttgatag atgacttctt aatcaattat catttccatt
    45601 gttgtttctt ggggtttcat cccttgtctt tgataaaagc ggagagcacc ctcgttatca
    45661 ttccagacac ttagggttag attattgcag ccaatttctt tagcataata gcagaaaaat
    45721 gacaataaaa tagcccctag atattttgaa aggaaagcat aggggctata tagtttaatc
    45781 aaaataaagc aaatctttgc tggtgcttgt aaagaggtcg aagccatcct tggtaacaac
    45841 accgcagtct tcaatacgaa caccgacttt accagggata tagatacctg gttcaacaga
    45901 gaagcacatg ccttcttcga tgaccatgtc gtttccttcc atgatagatg ggaattcatg
    45961 gacatccata ccgataccat gcccgagacg gtggttgaag tactcaccat aaccagcttt
    46021 ttcgatgacc tcacgggcag cgcggtccac ttcatgagca gtcacacctg gcttgataaa
    46081 gtcaagagca gcttgttggg cttcaagagt caagttgtaa atatctttct tgaattggtc
    46141 tggtttgccg acagcgactg tacgagtcat atctgacgca tagccattga ccagaacacc
    46201 caggtcaaag aggagaagag catcattttc aaccttatta gctgctggaa tgccgtgtgg
    46261 attcgcagca ttatcaccag tcaagaccat ggtatcaaag ctcatttcgt aaccttcacg
    46321 tttcatggca aagtcaattt gtgcgatgat atctgtctca gtcttatcaa gagaaatatt
    46381 gtcaaaacca acatgaacag ccttgtcagc ataaagacct gcaaccatca ttttttgcac
    46441 ttcatcagct gatttgatga ggcgcatgcg ttggatacga ggagtgaggt tgtcaaactc
    46501 agcagtctca aaaactgttt tcaaaccatg gtatttggtc aagatgagat tgtcaaactc
    46561 aacagcgaca cgtttgaagt caagttgtgg aagagcatgt ttgatttttt gccatggatt
    46621 ttcagaatcg acatagccca ctactgggaa ggaaacggtg ctacttgcac gttctacttc
    46681 aagagctggg acaaagagga gaggttcctg atctgctagg acaaagagga acatttggcg
    46741 ttcatgggga tcactgtaaa aaccagtgag gtaattgatt gtgacggggt cagatacgac
    46801 agcgacgtct agtttttctg attcaagata tgttaggatt tgttgtaatt tagacatatg
    46861 ctaccttctt tctatccctc tattttggca aaaaatgaga gaaaatgcaa gggagaaggg
    46921 taaaagaaaa gacaaaaaac tccgacaaga taacggagtt ctttgatatc attttccttt
    46981 gtttaagaaa agtcagcctt gcttttgacg tcactgtact cttcagcgat ttcttggctg
    47041 aggatatcct cataggcagg gagttggatg tcctgaccat atttcttctt gagggcagta
    47101 gtaactaggc gataagccag attggcatta cgagagagga taggcccgtg gaagtaggaa
    47161 ccaaagacat tcttataatg aaccccttca ccgacctttt cttcgttgtt tccatttcca
    47221 tagacaacct gtcccagcgg tttttggtca tcagagagga aggtacggcc ttggtgattt
    47281 tcaaatccat agtaggtttc atcgaaatct tcattgtgaa tcttgatgtc accgataaaa
    47341 cggttattgg tctggttgag cgtgtagtgt cccatgaccc ctagcccttc gatacgtttt
    47401 cctgaagctt caacataata ttgacccaat agttggaaac caccgcagat agccagaact
    47461 acaccgtcgt tttggatgta gttgtcaatg ctctcttttt tagcaggtag gtcgtctgca
    47521 atgatacttt gttcaaagtc ttgaccacca ccgaaaaagg cgatgtcgta gtgattttca
    47581 tcaaagtcat catggagaga aacgatgtca acggtcacat gggctcccag tttttcagcc
    47641 acatacttga gcatgaggat gtttccattg tccccgtagg tattcatgag atttccgtag
    47701 aggtgggcaa tgttgagctg ataggggtaa ttgccatctt ttgaggaaag tgaagtataa
    47761 accattagtt catctccttt ctaacaatct gacgactagc cagcagttca cgaaattcca
    47821 gcatggcagt ataagttgcc agaatatagg catgcttgca gtcttgattc tcaatggtct
    47881 tgagaacttg ctccagatta ctcgtttcag tgattttctc agctggatag ccagtcactc
    47941 ggaggcgacg agcgatttca gaatgacgaa caccgccagc gttgatttca ggaatgtcca
    48001 tgtcagtgat ttgttcaaag tctgcatccc agatccagct agtgtcaatt ccatctgcat
    48061 agttggcatt aaggaggaca gataggctaa atggataagg tgctagtttg atcatttcga
    48121 tagcttgggt tgcaccgact ggatttttaa tcaagacaag ggtacattcc ttgtcaccga
    48181 tatgaaaggt ttcttggcgt ccaaagacag cacggctctt gtcaaatccc tgtttgatga
    48241 gttgcgaatc ggcacctagg aaacgggcga tggccacagc agctagggcg ttatagatat
    48301 tatagagccc gccgatttgg ataccgtatt cttggccgtc tatgacaaag cgagagcgat
    48361 tgttggtcaa ctcaaccagt tttgtcaaac gatagtcgag atcaggacgt ttacatccac
    48421 aaccttcaca gatataggta cccaagtttg cataggtatt atgctcatat ttgaggatgc
    48481 cttggcagtc aggacagaga atcccttcgg tattgtagtg agccagttgg gctggtcctt
    48541 tttccaagtc aaaaccaaaa tactctatag ggtttggaat agttggcttg tagaaaagtg
    48601 gactgtctcc gttaaggaga acagtagcag ttggaacttt ccgaatggca tccaatatca
    48661 tgttataggt agtatagatt tcaccgaaac ggtccatctg gtcacggaag atattagtaa
    48721 tgacaaaaag actaggctgg atatagtcac agatacgaga tagactggct tcgtcaattt
    48781 cgaggacggc aatatttttt ccagttttag aagatttggc tgttaggaag gttgttgcaa
    48841 tccctgtaat catgttggca ccgcttggat tggttagaac ttgaccatag acctctttta
    48901 aaatgccgac agtgagggca gttgtcaggg tttttccatt tgttccagtg acaacgacaa
    48961 tctcgtagtt cttagctagg ttttgtaaaa tatctttatc aaattgaagg gcgactttac
    49021 ctgggagcgt acttccacgg ccaagacggc ttaaaatgaa gtgggaagaa cgcccagcaa
    49081 gaaggcccaa agtagttttt aagttcatgt ttctattata tcataaaaga ggagaaagac
    49141 agatttgaga ttccgcagaa gtaaaaacag cccaaagagg gctgttcgat acgattaaat
    49201 ctcaacttaa atcgcaaaca agtcattcaa gttctcagcc aaggttgggt gagtgaagat
    49261 ttgttttgtg aagtaagtgt aaggaatctt gttgtccata gcaacagtga tgatgttgat
    49321 gatttcttga gaaccttctg agaagatgct tgctccaaga atttcttttg tttcagtatt
    49381 gacaacagct ttgaaggcac cgcgaaggtc tccatttacg tgaccacgag gcatggctgc
    49441 aacggggatt tccttaacag cgtatggaag tttcaaatca gctgcttggc tttcagtcaa
    49501 accaacttgt gaaagtgcag gtgtgatgaa catagtattt ggcacattga gacggtcttc
    49561 aagtgtgtag ctgccatctc cagcaaggta gctgtaaaca acacggaagt catcaagtga
    49621 aatgtaagta aattgaaggc caccgttgat atctccaact gcaaagacac caggaacgtt
    49681 tgtttgacag tgtttgtcta ctttaatagc accacgttca gttagttcaa tatctgtatt
    49741 ttcaagttga agtggttcta catttggttt gcgtccagtt gcgtagagaa gggcgtcgaa
    49801 acggtaagtt tcgtcttcag ttacgacaag cacttggtca ccatcgtttt tgatttcagt
    49861 agtatggata ttttgaagca attcaatgcc atcttcttcc atgtattgtt tagcaagagc
    49921 tgcgatggaa ggttctgcac gaggaaggaa agtatccaag gcatctagga ctgtgacctt
    49981 gcttccaagt ttgttgtaaa ggccggcaaa ttcaagaccg atatttccgc caccaaggat
    50041 tccaagtttt tcaggtaatt tgtccaagtt ttggatacct gttgagtcaa agatgttttt
    50101 gcttgtagca agtccaggga ttggcaagac gtttgaaaca gcaccagtgt tgatgacgat
    50161 tgtttcagca gtcagttctt tcttttcatc accagcttgg atttcgatga ctttatttga
    50221 aaggaagtga gcttccgcat caaagatatc tacgcctgta ccagcaacag tcgcatagtt
    50281 tttaccgttg aggcgaccag tgatcgtgtt tttagtagca atcacttctt caaaagacaa
    50341 gtccttttca gcagcaacta gcaaggtttt agttgggata caaccaatgt tgatacaagt
    50401 tccaccgtac atagccttgc tgcgttcaac gagggcaact tttttgccag ctgaagccaa
    50461 tttacctgct agtgttttac cagctttacc aaatccaata acaattaaat cgtatgttaa
    50521 catttatctt cctcctattc gaatttcatt ctagcacaag aaaaaaactt ttgcacaatt
    50581 ctgctacgga aaagacagaa aaagataaaa acgctttcca gacaaaaaac tagtaatttt
    50641 ttgacaagct tgataaacta aaatcctatc tatttttata taagatagaa taaatgttcg
    50701 aaaataggag gttttatgaa atcgaatcgt tatattattg cctttgctgg ggtcatttta
    50761 cacttaatgc tgggttcgac ttatgcttgg agtgtttatc gtaaccctat tattgaaaaa
    50821 acgggatggg atcaggcttc tgttgccttt gcctttagtc tagcaatctt ttgtttgggc
    50881 ttatcggctg catttatggg gcgtttggta gaaaaatttg gtccgagagt catggggagt
    50941 ctatctgctt ttctatacgc aggtggaaat atcttaacag gatttgcaat agaccgtcag
    51001 gagctgtggt tgttgtatct cgcttatggc attttaggtg ggcttggttt gggagcaggc
    51061 tatattaccc ctgtgtcgac gattataaaa tggtttcctg ataaacgtgg tctcgcaaca
    51121 ggtttagcga ttatggggtt tggttttgct tctttattga ctagtcccat agcgcaacac
    51181 ctcatcgcag gggtagggct tgtagaaact ttttatattt taggagcaag ttactttatt
    51241 atcatgctcc tagcttcaca attcattaag cgtccaaatg agcaagagct tgcaatttta
    51301 tcttcttcag ggaaagaaaa aacagcctct ttgacgcaag gaatggctgc aaatcaggct
    51361 ctaaaaagca atcggtttta tatactttgg attattttct ttatcaacat agcttgtggt
    51421 ttaggcttaa tttcagcggc atcgccaatg gcacaggaga tggctggctt gtctacaagt
    51481 catgcagcag taatggtggg cgttttaggg attttcaatg gatttggtcg cttgctctgg
    51541 gcgagcttat ctgactatat cggtcgccct ctaaccttta gtatattact gcttgttaat
    51601 cttttctttt ctctctcact ttggctcttt acagattccg ttttatttgt agtcgctatg
    51661 tctattttga tgacttgcta tggagctggt ttttcattga tcccagctta tctcagtgat
    51721 atttttggaa ccaaggaatt ggccgctctg catggatata ttttaacagc ttgggcaatg
    51781 gctggtttag cgggacctat tttattagca gagacttata aaatggctca ttcgtacaca
    51841 caaaccttgt tcgtttttct cattttatac agtatcgcct tggctttgtc ttattatcta
    51901 ggtcgttcaa tcaaaaaaga aagtcaaaaa ccgcttacat gattttctgt agaaatgggg
    51961 ctatcttttg ctctggtctt gtgttatact agataggttg caaagaaaac agtacttttc
    52021 ttttgtggaa aagaagcaac acgattttat atctagttat atgaaaatac gtcataaaaa
    52081 gaaaagtata aactaagccc tatagggtgg cttcgcacca cctttagaaa gaagaataac
    52141 gtgaaattta atgaattaaa cttgtctgct gatttgctgg cagaaattga aaaagctggt
    52201 tttgtagaag ctagtcctat ccaagaacaa actattcctt tggcccttga aggcaaggat
    52261 gttatcggtc aagctcagac tggtacagga aaaactgcag cctttggctt gcctaccctt
    52321 gaaaaaatcc gtacagaaga agcgactatc caagccttgg tcatcgctcc aactcgtgaa
    52381 ctagctgtcc aaagtcaaga agaactcttc cgctttggtc gtagtaaggg agtcaaagtc
    52441 cgttcagtat atggcggatc aagcattgaa aaacaaatta aggctcttaa atctggtgcc
    52501 catatcgtgg tgggaactcc aggtcgcctc ttggacttga ttaaacgcaa ggccttgaaa
    52561 ttacaaaaca ttgaaaccct tatccttgac gaagcggatg aaatgcttaa catgggcttc
    52621 cttgaagaca tcgaagccat tatttcccgt gtacctgaga accgtcaaac tttgcttttc
    52681 tcagcaacta tgccagatgc catcaaacgt atcggtgttc agtttatgaa agcccctgaa
    52741 catgtcaaga ttgcagctaa ggaattgaca acagaattgg ttgaccagta ctatatccgt
    52801 gttaaggaac aagaaaaatt tgacaccatg actcgtctca tggatgtggc acaaccagaa
    52861 ctcgctattg tatttggtcg taccaaacgc cgtgtggatg aattgactcg tggtttgaaa
    52921 attcgtggct tccgtgcaga aggaattcat ggcgacctag accaaaacaa acgtcttcgt
    52981 gtccttcgtg actttaaaaa tggcaatctt gatgttttgg ttgcgacaga cgttgcagcg
    53041 cgtggtttgg atatttcagg tgtgacccat gtctacaact acgatattcc acaagatcct
    53101 gagagttatg ttcaccgtat cggtcgtaca ggtcgtgctg gtaagtcagg tcaatctatt
    53161 acttttgttg ctccaaacga aatgggttac cttcaaatca ttgaaaactt gactaagaaa
    53221 cgcatgaaag gtctcaaacc tgcaagtgta gaagaatcct tccaatcaaa aaaacaggta
    53281 gctctcaaga aaatcgaacg tgattttgca gatgaaacca ttcgtgccaa ctttgagaaa
    53341 tttggtaagg atgctcgcaa attggctgct gagtttactc cagaagaatt ggcaatgtat
    53401 atcttgagtc tgacagtcca agacccagat agccttccag aagtggagat tgcacgtgaa
    53461 aaaccactac cgtttaaacc atcaggtaat ggtttcggtg gtaaagctaa gggaggtcgt
    53521 ggaggccgtc gtggggacga ccgtcgagag cgtgatcgcc gtggcaatgg tcgccgtgat
    53581 gagttcaaaa aaggaagtcg tggcaacgat cgttttgata aggaaaaacg ttaccgtaag
    53641 gataataaaa aaccacgcaa tactttaagc gaaaagcaaa caggctttgt tattcgtaac
    53701 aaaggcgata aataagaaaa agcggttcaa aatgaatcgc ttttttatat aaggagaccg
    53761 aatgtgaaaa gacaaataaa attattatat tatcttttat aatgttatga tacacaaaaa
    53821 taggcaactt gtcaatagaa aaggaacaat ttaattaaaa atattctggt ttttaattaa
    53881 attgtaagtc aatgcaagtc aataaggaat tttcagataa ttattgaaaa agagacgttt
    53941 ttatgttata atgatagcga ttaaattcga ggtgaaaaat ggcacattta ttagaaaaaa
    54001 ctagaaaaat tacatcaatt ttgaaacgct cagaggagca gttgcaggat gagctccctt
    54061 acaacgctat tacgcgtcag ttagcggata ttattcattg caatgcctgc attatcaata
    54121 gtaagggacg tctgcttggc tattttatgc gttataaaac aaatacagat cgcgtagagc
    54181 aattcttcca aactaagatt ttcccagatg actacgttca aggggctaat atgatttacg
    54241 aaacagaagc aaacttgcct gttgagcatg atatgagtat tttccctgtt gagagtagag
    54301 atgattttcc agatggcttg acgactattg caccgattca tgtatcgggg attcgccttg
    54361 gttctttgat tatttggcgt aatgataaaa aattcgaaga tgaggacttg gttcttgttg
    54421 agattgccag taccgttgtt gggattcagc ttcttaactt ccaacgtgaa gaagatgaga
    54481 aaaatattcg tcgtcgtact gctgtcacca tggcggtcaa taccctttct tactccgaac
    54541 tccgtgctgt ttcagcaatt ttaggggaat taaatggaaa tgaagggcag ttgactgcgt
    54601 cagtgattgc agatcgtatc ggaatcactc gctctgtgat tgtcaatgct cttcgtaaac
    54661 ttgagtctgc ggggattatt gaaagtcgct cacttggaat gaagggaacc tatcttaagg
    54721 tcttgatttc agatattttt gaagaagtga agaaaagaga ttactaatga caaaggcttt
    54781 aatttcgatt gattatacag aagattttgt tgctgatagt gggaagctga cagcaggtgc
    54841 tccagctcag gcgatttcgg atgccattag caaggtaact cgattagctt ttgaacgagg
    54901 agattatatc ttctttacta ttgatgctca tgaagaaaac gattttttcc atccggaaag
    54961 taagttattt cctcctcata atctgattgg gacgagtgga cggaatttat atggagattt
    55021 ggggatcttt tatcaagagc atggttcaga cagtcgtgtc ttttggatgg ataaacgcca
    55081 ttactcagct ttttcaggga ctgacctaga tattcgtttg agagagcgta gagtgtctac
    55141 cgttatctta acaggtgtct tgacggatat ctgtgtccta catacagcta tagatgccta
    55201 taatctagga tatgacatcg agattgttaa accagctgtt gcttccatct ggcctgaaaa
    55261 tcatcaattt gccctaggtc atttcaaaaa tacactcgga gctaagttag tagatgaaaa
    55321 tctaaatgaa ctttctgagt aacctggttg gtgaaaatga aaaaatttga aaaaaagtgt
    55381 tgacaagcat cccaaaagtt gatatactag taaagtaatc gatgcgggga tggcggaatt
    55441 ggcagacgcg caggactaag gatcctgtga ccgctttagg tcgtgagggt tcaagtccct
    55501 ctctccgcat aggaaaagag ttagctaaag ctagctcttt tgtatttctc taaaaaatta
    55561 gaatccagtc aaatgtagtg gagaatcagc gaaaatatgg gaaaactgat ccttgtttct
    55621 gcttttgtca tagaagaata ataaagatta tcttcttcaa attctccgat attctctaaa
    55681 gttttgtgca agttgcacag aactttttta tttttttggt catcttgcca tagaaatata
    55741 aagcgttttc atatataata taattatcaa aagacaaaag gagttcacct catggtagaa
    55801 ttgaatctta aaaatattta caaaaaatat ccaaacagcg aacactattc agttgaagat
    55861 ttcaacttga acatcaaaga taaagaattt atcgttttcg taggaccttc aggatgtggt
    55921 aaatcaacta cactccgtat gattgctggt cttgaagaca ttacagaagg tactgcatct
    55981 atcgatggcg tggttgtcaa cgacgtagct ccaaaagacc gtgatatcgc catggtattc
    56041 caaaactacg ctctttaccc acacatgact gtttatgaca acatggcttt cggcttgaaa
    56101 ttgcgtaaat acagcaaaga agacattaac aaacgtgttc aagaagcagc tgaaatactt
    56161 ggattgaaag aattcttgga acgtaaacca gctgaccttt caggtggtca acgtcaacgt
    56221 gttgccatgg ggcgtgcgat tgtccgtgat gcgaaagtat tcttgatgga cgaacctttg
    56281 tcaaacttgg atgccaaact tcgtgtatca atgcgtgctg aaatcgctaa aattcaccgt
    56341 cgtatcggag ctacaactat ctatgtaact cacgaccaaa cagaagcgat gacacttgca
    56401 gaccgtatcg ttattatgtc agctactaag aaccctgctg gtacaggtac tatcggacgt
    56461 gtagaacaaa tcggtactcc tcaagaagtt tacaaaaatc cagttaacaa attcgttgca
    56521 ggattcatcg gaagcccagc tatgaacttc atcaccgtga aattggttgg tagcgaaatt
    56581 gtttctgacg gtttccgttt gaaagtgcca gaaggagcat tgaaagttct tcgtgaaaaa
    56641 ggctacgaag gaaaagaatt gatctttggt atccgtccag aagacgtgaa tgcagaacct
    56701 gctttccttg aaacattccc agactgtgtt gtaaaagcga ctatctctgt atcagaactg
    56761 cttggttcag aatctcacct ttactgccaa gttggtaaag acgagtttgt tgcaaaagtt
    56821 gatgctcgtg actacttgca aacaggtgca acagttgagc ttggatttga cttgaacaaa
    56881 gcacacttct tcgatgtaga aactgaaaaa acaatctact aaaataaata aaattcaaag
    56941 cactacaaga aaatatatct ctttatcaat tgtagtggag agatatcagt taatctaggg
    57001 agagaaacaa aatgcttctc tcctttttgc tagggaagtc atattatgca tctatattgt
    57061 gatgctcttt atactcttcg aaaatctctt caaaccacgt caacgtcgcc ttgccgtacg
    57121 tatgattact gatttcgtca gttttatctg caacctcaaa gatgtacttt gagcagctta
    57181 cggctagttt cctagtttgc tctttgattt ccattgagta ttattgtgag taccatctac
    57241 aagtgaagct atatgcgtaa actacgtgag caattgaatt cgaactagag aggtaataat
    57301 aaatttatgc tatagttatg gtgacttgta tgcttttgat tctagtttat caaataatag
    57361 attagaattg tcagataata tcattttgtg ttataatgaa gaaaaaacag aggtgttcaa
    57421 atgtcagaag caggtcataa gtttttagca aaattgggga aaaaacgctt acgtccaggt
    57481 ggaaagcgtg ccacagattg gttaattgca gaaggaggat tttcaaaaga aaagagaata
    57541 ctagaggttg cgtgtaatag gggaactaca gcaattgagt tggcacagcg ttttggttgc
    57601 aagataactg ctgttgatat ggatgctcaa gctttagaag tggctaaaaa atctgctgga
    57661 acggcaggtg ttgctcattt aatcagtttt gaaagagcaa atgcaatgaa acttccttat
    57721 caagatgcta gttttgatat tgttataaat gaagctatgc tgactatgca agccgatcaa
    57781 gctaagaaaa aatgtgtaat ggaatatcta agggtattaa aacctggagg tcttctcttg
    57841 acacatgatg tgcttcttaa ggaagctaaa gagtctatca gacaggaatt atcacaagca
    57901 attcatgtaa atgtaggtcc tttaactcaa gatggttggg aacaggtgat gatagaatca
    57961 ggttattgtg atgtgaaagc attgactggt gaaatgacat taatgaaatt atcgggtatg
    58021 atttatgacg aaggtttgct aggaactttg aaaatttgtg taaatgcttg taaaaaggag
    58081 aatagaaagc agtttttaac tatgtataaa atgtttgcta agaataaaca gaaattgggc
    58141 tttattgcga tggctagtta taaatcgtca aaacgttaga taattattga agttaacttt
    58201 tccttttttc tttcttaaaa aatatgctat aatagagagt aaaaaacttt gaaagaaaga
    58261 aaaaagatga atttaaaaga ttacattgca acaattgaaa attatccaaa ggaaggcatt
    58321 accttccgtg atattagtcc tttgatggct gatggaaatg cttatagcta cgctgttcgt
    58381 gaaatcgttc agtatgctac tgacaagaaa gtcgacatga tcgtgggacc tgaagctcgt
    58441 ggatttatcg tgggttgtcc agttgccttt gagttgggaa ttggttttgc gcctgttcgt
    58501 aagccaggta aattgccacg tgaagttatt tctgctgact atgaaaaaga gtacggtgtc
    58561 gataccttga ctatgcacgc ggatgccatt aagccaggtc aacgtgttct tattgtagat
    58621 gaccttttgg cgacaggtgg aactgttaag gcaactatcg agatgattga aaaacttggt
    58681 ggtgttatgg caggttgtgc cttccttgtt gaattggatg aattgaacgg ccgtgaaaaa
    58741 attggtgact acgactacaa agttcttatg cattattaat gaaaacagtc cctagggctg
    58801 ttttctctac actaggatat aaaaatagac tataactagt tagagaaaaa ctataattga
    58861 aaactatatc ttcttgcagt ataataaaag gactaagtgt ttgagatttg tcttcaaaca
    58921 tatgcaatta ttcctgaaag agtacagtta ggagagggtt atgccgattc gaattgataa
    58981 aaaattgcca gctgttgaga ttttacggac agagaatatc tttgtcatgg atgatcaacg
    59041 tgctgcccac caagatatcc gtcctttgaa gattttaatt ttaaatctca tgccacagaa
    59101 aatggtcaca gagacccagt tgttgcgcca cttggctaat acacccctac aactggatat
    59161 tgattttctc tatatggaga gccaccgttc taaaacaact cgttcagagc acatggagac
    59221 cttctataaa acttttcctg aagtcaagga tgagtatttt gatgggatga tcatcacggg
    59281 tgctccagtt gagcatttac catttgagga agtggactat tgggaggaat ttagacagat
    59341 gcttgagtgg tctaagactc atgtctattc gacccttcat atctgttggg gggctcaggc
    59401 tgggctttat ctgcgctatg gtgtagaaaa ataccagatg gacagtaagc tatcaggtat
    59461 ttatcctcag gacaccctaa aagagggtca ccttctattt agaggctttg atgatagcta
    59521 tgtatcccct cattcacggc acacggagat ttctaaggaa gaggtcttaa acaagaccaa
    59581 tctcgagatt ttatcagaag gacctcaggt tggggtttct attttggcca gtcgtgattt
    59641 acgagaaatt tatagttttg gtcatttgga gtatgaccgt gataccttgg caaaagagta
    59701 ttttcgagat cgtgatgcag gtttcgaccc acatattcca gaaaattact ttaaagatga
    59761 tgatgttaat caggtacctt gtctttgttg gtcttcatct gcagccctct ttttcagtaa
    59821 ttgggtaaac catgcggtct atcaggagac gccttttgat tggagaaaga tagaagatga
    59881 tgcatctgca tatgggtatt tataagagga attatgacat atttagacgc ttttaaatca
    59941 ggtaccttgg ttttaccgag tgccctgctc ttgcatttta aggaactctt tccttctagc
    60001 gacgattttc tggtttggca atttttctat ttgcaaaata cgacaggctt agaagaaatg
    60061 tcgccaagcc agattgctga aaggattggc aaggaaattt cggatgtcaa ccagtccatt
    60121 tctaatctga cggaaagggg actgctccag tatcgtacta tcgaattaaa tggcgaaatt
    60181 gaattgctct ttgatgctag tttggccttg gaacgtttgg atgacctgtt tggagcagtt
    60241 cattcaagtt cagaccagct aacacctcaa aaccagctca aggatttggt ggaaaccttc
    60301 cagcaggagt tgggacgatt gttgacgcct tttgagattg aggatttgac caagacacta
    60361 aaggaagatg gaaccagtgc tgacttgatt aaggaggctc ttcgtgaagc tgttttgaat
    60421 ggaaaaccaa actggaagta cattcaggct attttgagaa actggcgcca tgaaggaatc
    60481 aagagtgtgg ctcaaattga ggccaagaga gcagaaagag aagcaagcaa tcctcagttg
    60541 acacaggtat ctgcagattt cagaaatgcc atggatctct ggaaggatta atccatgcaa
    60601 gtaggcttga aatccgagta agatttgcaa gctgtgtata attgtgatag aataaataga
    60661 aaataaattg aaaaaagagg tatgtgaaat gtcacgtaaa ccatttatcg ctggtaactg
    60721 gaaaatgaac aaaaatccag aagaagctaa agcattcgtt gaagcagttg catcaaaact
    60781 tccttcatca gatcttgttg aagcaggtat cgctgctcca gctcttgatt tgacaactgt
    60841 tcttgctgtt gcaaaaggct caaaccttaa agttgctgct caaaactgct actttgaaaa
    60901 tgcaggtgct ttcactggtg aaactagccc acaagttttg aaagaaatcg gtactgacta
    60961 cgttgttatc ggtcactcag aacgccgtga ctacttccat gaaactgacg aagatatcaa
    61021 caaaaaagca aaagcaatct ttgcgaacgg tatgcttcca atcatctgtt gtggtgaatc
    61081 acttgaaact tacgaagctg gtaaagctgc tgaattcgta ggtgctcaag tatctgctgc
    61141 attggctgga ttgactgctg aacaagttgc tgcctcagtt atcgcttatg agccaatctg
    61201 ggctatcggt actggtaaat cagcttcaca agacgatgca caaaaaatgt gtaaagttgt
    61261 tcgtgacgtt gtagctgctg actttggtca agaagtcgca gacaaagttc gtgttcaata
    61321 cggtggttct gttaaacctg aaaatgttgc ttcatacatg gcttgcccag acgttgacgg
    61381 tgcccttgta ggtggtgcgt cacttgaagc tgaaagcttc ttggctttgc ttgactttgt
    61441 aaaataatca gtaagtagca aaagctaggt ggaacagcat tcagatgtct gttacatttt
    61501 ttataggaga gcaaagattg aaaacaaaaa ttggattagc aagtatctgt ttactaggct
    61561 tggcaactag tcatgtcgct gcaaatgaaa ctgaagtagc aaaaacttcg caggatacaa
    61621 cgacagcttc aagtagttca gagcaaaatc agtcttctaa taaaacgcaa acgagcgcag
    61681 aagtacagac taatgctgct gcccactggg atggggatta ttatgtaaag gatgatggtt
    61741 ctaaagctca aagtgaatgg atttttgaca actactataa ggcttggttt tatattaatt
    61801 cagatggtcg ttactcgcag aatgaatggc atggaaatta ctacctgaaa tcaggtggat
    61861 atatggccca aaacgagtgg atctatgaca gtaattacaa gagttggttt tatctcaagt
    61921 cagatggggc ttatgctcat caagaatggc aattgattgg aaataagtgg tactacttca
    61981 agaagtgggg ttacatggct aaaagccaat ggcaaggaag ttatttcttg aatggtcaag
    62041 gagctatgat gcaaaatgaa tggctctatg atccagccta ttctgcttat ttttatctaa
    62101 aatccgatgg aacttatgct aaccaagagt ggcaaaaagt gggcggcaaa tggtactatt
    62161 tcaagaagtg gggctatatg gctcggaatg agtggcaagg caactactat ttgactggaa
    62221 gtggtgctat ggcgactgac gaagtgatta tggatggtgc tcgctatatc tttgcggcct
    62281 ctggtgagct caaagaaaag aaagatttga atgtcggctg ggttcacaga aatggtaaac
    62341 gctatttctt taataataga gaagaacaag tgggaaccga acatgctaag aaaatcattg
    62401 atattagtga gcacaatggt cgtatcaatg attggaaaaa ggttattgat gagaacgagg
    62461 tggatggtgt cattgttcgt ctaggttata gcggtaaaga agacaaggaa ttggcgcata
    62521 acattaagga gttaaaccgt ctgggaattc cttatggtgt ctatctctat acctatgctg
    62581 aaaatgagac cgatgctgag aatgacgcta aacagaccat tgaacttata aagaaataca
    62641 atatgaacct gtcttaccct atctattatg atgttgagaa ctgggaatat gtaaataaga
    62701 gcaagagagc tccaagtgat acagacactt gggttaaaat catcaacaag tacatggaca
    62761 cgatgaagca ggcgggttat caaaatgtgt atgtctatag ctatcgtagt ttattacaga
    62821 cgcgtttaaa acacccagat attttaaaac atgtaaactg ggtagcggcc tatacgaatg
    62881 ctttagaatg ggaaaaccct tattattcag gagaaaaagg ttggcaatat acctcttctg
    62941 aatacatgaa aggaatccaa gggcgcgtag atgtcagcgt ttggtattaa gcgatgattt
    63001 gaaagaggga tgtgatagta gcaccctctt tttctttgtt ttatgatagt tcatcctcga
    63061 gtaaattcaa gatcttgctc ggaaatgaag cttatatagt agattgaata tagacaaata
    63121 ccttgtgatt ggtaaaacat tttagaaatt catttacctt tcctaatcga cttggtttca
    63181 tcttatttca atctattata gtattgggga atttcttcaa accacatcag cttggtcagt
    63241 tctacctgcg acctcaaaac ttgtgctttg gtcaagctgg gtttagtttc ctagtttgct
    63301 gatggatttc cattgactat aagcatccaa ccctcttttt gtcttctaaa gaattcttaa
    63361 attatcagtc tattgcaact tttctcatat aagttctttg tcttgctatt tgttttcctt
    63421 agtagtatac taaggtagta atcattaaga agtggttaca aaaaataatg aatgaggtaa
    63481 agaaaatggt agaattgaaa aaagaagcag taaaagacgt aacatcattg acaaaagcag
    63541 cgccagtagc attggcaaaa acaaaggaag tcttgaacca agctgttgct gatttgtatg
    63601 tagctcacgt tgctttgcac caagtgcact ggtatatgca tggtcgtggt ttccttgtat
    63661 ggcatccaaa aatggatgag tacatggaag ctcttgacgg tcaattggat gaaatcagcg
    63721 aacgcttgat tacactcggt ggaagcccat tctctacatt gacagagttc cttcaaaata
    63781 gtgaaatcga agaagaagct ggtgaatacc gtaatgttga agaaagcttg gaacgtgttc
    63841 ttgttatcta ccgttacttg tcagaacttt tccaaaaagg tttggatgtc actgatgaag
    63901 aaggtgacga tgtgacaaac ggtatctttg caggcgctaa aactgaaaca gataaaacaa
    63961 tttggatgct tgcagccgaa cttggacaag cacctggttt gtaagaaata aggaaacata
    64021 gataaatctg taggaaattt cttacagatt ttttctattt tgtaagctat tccaaaccag
    64081 tctttttttg agttttttga taaaatagta ctatcagtga aaaggatgga agcatgacta
    64141 agaaaatcgt agctatttgg gcccaggatg aagagggtgt gattggtaag gaaaatcgtc
    64201 tgccttggca tttgccagca gaattgcagc actttaaaga aacaactctg aatcatgcta
    64261 tcttgatggg gcgtgtgacc tttgatggga tggggcgtcg cttgcttcca aaacgggaaa
    64321 ccctgatttt gacgcgtaat ccggaagaaa agatagatgg ggttgctact tttcaggacg
    64381 tccagtctgt tcttgactgg tatcaggatc aagaaaagaa tctctacatt atcggtggga
    64441 agcaaatttt tcaggctttt gaaccttacc ttgatgaagt gattgtcact cacattcatg
    64501 ctcgggtgga aggagatacc tatttccctg aagagcttga cttgtctctt tttgagacag
    64561 tttcaagcaa attttacgcc aaagatgaga agaatcctta tgattttacc atccaatacc
    64621 gcaagagaaa ggaagtataa tggaacggag tttatttggt ctattcacgg cttttctgtg
    64681 tttcatctgc tttctggcag gagcacaggc ttttcgtaaa aagcgttacg ggctttctat
    64741 cctcctttgg ttaaatgcct ttaccaatct ggtcaatagt attcatgctt tttacatgac
    64801 cttattttag atagaatgac agtatagaat ggaaggaaat catgtctaca aatagaaaaa
    64861 atgatatgat ggtttattgc tcattttgtg gcaaaaacca agaagaagta caaaaaataa
    64921 ttgctggcaa caatgctttt atttgtaatg aatgcgtgga gttagctcag gaaatcattc
    64981 gagaagaatt ggttgaggaa gtcttggcag acttgtctga ggtgccaaaa ccaattgaac
    65041 tcctccatat cttgaaccac tatgtaattg gtcaagatcg tgccaagcgt gccttggcag
    65101 tggcggttta taaccactac aaacgcatca atttccacga tacacgcgaa gagtcagaag
    65161 atgtggattt gcagaagtca aacattttga tgattggccc aactggttca gggaaaactt
    65221 tccttgccca gaccttggct aagagcttga atgtgccttt tgctattgcg gatgcgacag
    65281 ctctgacgga ggctggttat gtgggtgagg acgtggaaaa tatcctcctc aaactcttgc
    65341 aggttgctga ctttaacatc gaacgtgcag agcgtggcat tatctatgtg gatgaaattg
    65401 acaagattgc caagaagagt gagaatgtgt ctatcacacg tgatgtttct ggtgaagggg
    65461 tgcaacaagc ccttctcaag attatcgagg gaactgttgc tagcgtgccg cctcaaggtg
    65521 gacgcaaaca tccacaacaa gagatgattc aagtggatac aaaaaatatc ctcttcatcg
    65581 tgggtggtgc ttttgatggt attgaagaaa ttgtcaaaca acgtctgggt gaaaaagtca
    65641 tcggatttgg tcaaaataat aaggcgattg acgaaaacag ctcatatatg caagaaatca
    65701 tcgctgaaga cattcaaaaa tttggtatta tccctgagtt gattggacgc ttgcctgttt
    65761 ttgcggctct tgagcaattg accgttgatg acttggttcg catcttgaaa gagccaagaa
    65821 atgccttggt gaaacaatac caaactttgc tttcttatga tgatgttgag ttggaatttg
    65881 acgacgaagc ccttcaagag attgctaata aagcaatcga acggaagaca ggggcgcgtg
    65941 gacttcgctc cattatcgaa gaaaccatgc tagatgttat gtttgaggtg ccgagtcagg
    66001 aaaatgtgaa attggttcgc atcactaaag aaactgtcga tggaacggat aaaccgatcc
    66061 tagaaacagc ctagaggtga ctatggaact taatacacac aatgctgaaa tcttgctcag
    66121 tgcagctaat aagtcccact atccgcagga tgaactgcca gagattgccc tagcagggcg
    66181 ttcaaatgtt ggtaaatcca gctttatcaa cactatgttg aaccgtaaga atctcgcccg
    66241 tacatcagga aaacctggta aaacccagct cctgaacttt tttaacattg atgacaagat
    66301 gcgctttgtg gatgtgcctg gttatggcta tgctcgtgtt tctaaaaagg aacgtgaaaa
    66361 gtgggggtgc atgattgagg agtacttaac gactcgggaa aatctccgtg cggttgtcag
    66421 tctagttgac cttcgtcatg acccgtcagc agatgatgtg cagatgtacg aatttctcaa
    66481 gtattatgag attccagtca tcattgtggc gaccaaggcg gacaagattc ctcgtggtaa
    66541 atggaacaag catgaatcag caatcaaaaa gaaattaaac tttgacccga gtgacgattt
    66601 catcctcttt tcatctgtca gcaaggcagg gatggatgag gcttgggatg caatcttaga
    66661 aaaattgtga ggaaaagaaa atggcaaaaa caattcatac agataaggcc ccaaaggcta
    66721 tcggacccta tgttcaagga aaaatcgttg gcaacctttt gtttgctagc ggtcaagttc
    66781 ccctatcccc tgaaactggg gaaattgtag gagagaatat ccaagaacag acagagcaag
    66841 tcttgaaaaa catcggtgct attttggcag aagcaggaac agactttgac catgttgtca
    66901 aaacaacttg tttcttgagc gatatgaacg actttgttcc ttttaatgag gtttaccaaa
    66961 cggccttcaa agaggaattc ccagctcgtt cagctgtgga ggtagctcgt cttcctcgtg
    67021 atgtaaaagt cgaaattgaa gtcatcgcag agattggata agctagttga agtttggtgt
    67081 tgccaaactt cttttgatat aaggagaaaa agatgacaaa gaaacaactt cacttggtga
    67141 ttgtgacagg gatgagtggc gcagggaaaa ctgtagccat tcagtccttc gaggatctag
    67201 gttatttcac cattgataat atgccgccag ctctcttgcc taagtttttg cagctggttg
    67261 aaattaagga agacaatcct aagttggcct tggtagtgga tatgcgtagc cgttctttct
    67321 tttcagagat tcaagctgtt ttggatgagt tggaaaatca agatggtttg gatttcaaaa
    67381 tcctcttttt ggatgcggct gataaggaat tggtcgctcg ttacaaggaa accagacgga
    67441 gtcacccact agcagcagac ggtcgtattt tagatggaat caagttggaa cgtgaactct
    67501 tggcaccttt gaaaaatatg agccaaaatg tggtggatac gactgaactc actccacgtg
    67561 agctgcgcaa aacccttgca gagcagtttt cagaccaaga acaagcccag tctttccgta
    67621 tcgaagtcat gtctttcgga tttaagtatg gaatcccgat tgatgcggac ttggtctttg
    67681 atgtccgttt cttgccaaat ccctattatt taccagaact gagaaaccaa acgggtgtgg
    67741 atgaacctgt ttatgattat gtcatgaacc atcctgagtc agaagacttt tatcaacatt
    67801 tattggcctt gattgagccg attctgccaa gttaccaaaa ggaaggtaag tccgttttga
    67861 ccattgccat gggatgtacg ggtggacaac accgtagtgt ggcatttgct aaacgcttgg
    67921 tgcaggactt atccaagaat tggtctgtta atgaagggca tcgcgacaaa gaccgcagaa
    67981 aggaaacggt aaaccgttca tgagaaaacc aaagataacg gtgattggtg gagggactgg
    68041 aattcccgtc attctaaaaa gtctgcggga aaaagatgtg gaaatcgcag ctatcgtgac
    68101 ggtggcagat gatggtggtt cttcaggtga actccgaaaa aatatgcaac agttgacacc
    68161 gccaggtgat tttcgtaatg tccttgtggc catgtcggat atgcctaagt tttatgagaa
    68221 ggtctttcag tatcggttct ctgaggatgc cggagccttt gctggccatc cattgggaaa
    68281 tctcatcatt gctggcttgt cagaaatgca gggttcaacc tataatgcca tgcagttatt
    68341 gagcaaattt ttccatacaa cagggaaaat ttatccttcc agtgaccatc ctttgaccct
    68401 tcatgcagtc tttcaggatg ggacagaagt ggctggagag agtcatattg tagaccatcg
    68461 aggcataatt gacaatgtct atgtgaccaa tgccctaaac gatgatacgc ctctggccag
    68521 ccgtcgagta gtgcagacca tccttgaaag tgacatgatt gtcctagggc caggttctct
    68581 ctttacctct attttgccca atatcgtgat taaggaaatt gggcgggctc ttttggaaac
    68641 caaggcagaa attgcctatg tctgcaatat catgacccaa cgtggggaga cggaacactt
    68701 tacagatagc gaccacgtgg aagtcttgca tcgtcacctt ggtcgccctt ttatcgacac
    68761 tgtcttggtg aatattgaaa aagtgcctca ggaatacatg aattccaacc gttttgatga
    68821 atacttggtg caagtggaac acgattttgt aggtctttgt aagcaagttt cgcgcgtgat
    68881 ttcatctaac ttccttcgtc tggaaaatgg cggtgccttc cacgatggag atttgattgt
    68941 ggacgagttg atgcgcatta tacaggtgaa aaaatgagtt tcacagtagc agtaaaagaa
    69001 gaaatcctgg gccaacacca tctgagctgg catgaattat ctgccattat caaaatgtct
    69061 ggtagcatcg gtctctcgac ttcgggcttg actttgtcag ttgtgacaga aaatgccaaa
    69121 ctggcccgtc acctctatga gtcctttctc catttctatg aaatcaaatc tgaaattcgt
    69181 caccaccaac ggagcaatct tcgcaagaat cgcgtctata ccgtttttac agatgaaaag
    69241 gtgcaggatt tgttaagtga tttgcacttg gcagactctt tctttggcct ggaaacaggt
    69301 attgatgagg cgattttatc ggatgaggaa gcaggtcgtg cctatctctg tggcgctttc
    69361 ttggcaaatg ggagcattcg tgaccctgag tcaggcaagt accagttgga aatcagttct
    69421 gtttatctgg accacgcgca aggaattgcc tcccttctcc aacagttttt actggatgcc
    69481 aaggtgcttg agcgcaagaa gggggctgtg acctatctcc agcgagcaga agacattatg
    69541 gacttcttga tagtaatcgg agccatgcag gcacgtgatg attttgagcg ggttaagatt
    69601 ttgcgagaaa cccgtaacga cctcaatcgg gctaataatg ccgagacagc taatatcgct
    69661 cggacagttt ctgccagcat gaagaccatt aacaatatca gtaaaataaa agatatcatg
    69721 ggcttagaaa atttgccagt agatttgcag gaagtggcgc aactgaggat tcagcaccca
    69781 gactactcta tccaacagtt ggcagatagc ctcagcaccc ctctgaccaa aagtggtgtc
    69841 aatcacagac tcagaaaaat caataagata gccgatgaat tataaaacca cgaatcctat
    69901 gtgactcgtg gttctttttt ataaactagt agagtgtttt ggttgtactt tttgttcagg
    69961 gtcaatgtag ttgatagcgt tgttgacagc agttggagct tctccgaggc ctgtcgcaat
    70021 cagatcaatt tttccgtcat agtagcagca gtcaccgata gcatagatac ctgcttggct
    70081 ggattcctgt ttgctgttga cgataatctt gtgacggttg aggtcgagcc cccagttttt
    70141 aaggttaccg acagaagatt tgaaaccata gttgacaaag aggtggtcta ggtcaatggt
    70201 ttcagtttca tcagatttga cttttgtgat ttcaagttta tcaagtgttt ttccatttcc
    70261 aaggagttgg ctaggggcga atggtgtctt gatggttaca gatgattctt gcaaggcttg
    70321 aacactgtgt tccaaggcac ggaaattatc tctgcggtga acaagggtag ttggtgcgat
    70381 tttttcaaaa gccaaagccc aatccacagc cgagtctccc ccaccaagaa tcgtcacttt
    70441 cttaccagcg tattgctgaa tgttagaaac gtggtagtgg atattttcat agccctcaac
    70501 actttcaagt tccagcggac gtggtttgaa ggcaccgcca cccatagcga tgataactgt
    70561 tttagtcagg tgacttcctt tagaagttgt gatggcaaat tcttcttctt gtttgtcaat
    70621 ctcaagaacc gtttcattga gatgaatagg ggtatcaaat ccatttagct gttcaatcaa
    70681 gcggttagtc aactcttctc cagtcaggtt tgggaagcct ggtacgtcta ggatttcctt
    70741 ttcagggtag agaatagcag gttgtccacc tagctgggga agagagtcga tgatttgaac
    70801 cttggcttgg cgtaggtggg cataaaaggc tgcaaaaagc ccgacaggac caccacccac
    70861 aatggtaata tcatagagtt gagacatagt ttctcctttg ttttttctag tcagtttatt
    70921 ttatcatatt tttgttcaat gtaaaatgga ctaggatagg gaaaaaaatg ccagaaaatg
    70981 gtataatagg acgaaagtgt tttgataggg aggatatcag ggatgaattt tcaacaatta
    71041 tccaatctgc aatattggac cagtttgttt gcaagtccat ggacgatagc tatcaatctg
    71101 attgatattt tgattgttgc ttatatttta taccatttta caaaagctat tgcaggaacc
    71161 aagattatga ttttggtacg tggagttttg gtgtttattt tagctcaaat ccttgcaaat
    71221 atgattggtt tgactacgat ttcttggtta atcaatcaaa ttattactta tggggttatt
    71281 gcggcggttg ttatcttctc tccagagatt cggactggtt tggaacgttt gggaagagcg
    71341 acagatttct tttccaatgc ccctattagt gctgaggaac agatgattcg tgcctttgtt
    71401 aagtctgttg aatacatgag tcctcgtaaa atcggggcct tggttgctat tcagcgtgta
    71461 cgtaccttgc aggagtatat gtcgacagga attcccttgg atgctaagat ttctgcagaa
    71521 cttctcatta acatttttat tcccaacact cccctacatg acggtgcggt gattatcaaa
    71581 gaagaacgta tcgctgtgac gtctgcctat ctgcccttga caaaaaacac agggatttcc
    71641 aaggaatttg ggaccagaca ccgggcggct atcggtttat cagaagtctc agatgccttg
    71701 acttttgtcg tatcagagga aacgggagga atttcgataa cctataatgg aaggtttaag
    71761 cacaacctaa cacttgatga atttgaaaca gaattacgtg aaatcttact tccaaaagag
    71821 gaagtgggtc ttagttttaa agaacgattg ctaggaggat ggaaacatga aaaaaaatag
    71881 tttatatatc atatcctcac tcttttttgc ttgtgtctta tttgtctatg ctacggcgac
    71941 gaattttcaa aacagtacca gtgctaggca ggtaaaaacg gaaacctata ctaatacagt
    72001 aacaaatgtc cctattgaca tacgctataa tagtgataag tattttatta gcggttttgc
    72061 ttcagaagta tcagtggtct tgactggtgc aaatcgccta tcgctagcta gtgaaatgca
    72121 agaaagtaca cgtaaattca aggttactgc tgacctaaca gatgccggtg ttggaacgat
    72181 tgaagttcct ttgagcattg aagatttacc caatgggctg accgctgtgg cgactccgca
    72241 aaaaattaca gtcaagattg gtaagaaggc tcaaaaggat aaggtaaaga ttgtaccaga
    72301 gattgaccct agtcaaattg atagtcgggt acaaattgaa aatgtcatgg tgtcagataa
    72361 agaagtgtcg attacgagtg accaagagac attggataga attgataaga ttatcgctgt
    72421 tttgccaact agcgaacgta taacaggtaa ttacagtggt tcagtacctt tgcaggcaat
    72481 cgaccgcaat ggtgttgtct taccggcagt tatcactccg tttgatacaa taatgaaggt
    72541 gactacaaaa ccagtagcac caagttcaag cacatcaaat tcaagtacaa gcagttcatc
    72601 ggagacatct tcgtcaacga aagcaactag ttcaaaaacg aattaaaaat agaaaaggat
    72661 tttataacaa tgggtaaata ttttgggact gatggagtcc gtggagaagc taacctagaa
    72721 ctaacaccag aattagcctt taaactagga cgttttggag gctatgttct tagtcaacat
    72781 gaaacggaag cgccgaaagt ctttgtagga cgtgacacac gtatttcagg ggaaatgctg
    72841 gaatcggcct tggtggcagg tctcctttca gtagggattc acgtatacaa acttggtgtc
    72901 cttgcaacac cagcagtagc ttacttggtt gaaactgaag gagcaagtgc cggtgtcatg
    72961 atttctgcta gccacaaccc agcccttgat aacggaatca agttctttgg cggtgatggc
    73021 ttcaaactag atgatgaaaa agaagcagaa attgaagcct tgctagatgc tgaggaagac
    73081 actcttcctc gtccaagtgc agaaggctta ggaattttgg tagattatcc agaaggcttg
    73141 cgtaagtatg aaggatacct tgtttcaact ggaactcctc ttgatggaat gaaggttgcc
    73201 ttggatacag ctaatggagc agcttctacc agtgcccgtc aaatctttgc agaccttggt
    73261 gcccaattga cggttatcgg ggaaacacca gacggtctta acatcaacct taatgttggt
    73321 tcaacacatc cagaagccct tcaagaagtg gtcaaagaaa gtgggtcagc tattggtttg
    73381 gcctttgatg gagacagtga ccgcttgatt gctgttgatg agaatggtaa catcgtcgat
    73441 ggtgacaaga ttatgtacat catcggaaaa tacctttctg aaaaaggaca attggctcaa
    73501 aatacaattg tgacaactgt tatgtctaac cttggtttcc acaaggcctt gaatcgcgaa
    73561 ggtattaaca aggcagttac tgcagttggt gaccgctacg ttgttgaaga aatgagaaaa
    73621 tcaggctaca accttggtgg tgaacagtct ggtcacgtta tcttgatgga ttacaatacc
    73681 acaggtgatg gtcaattatc agcagttcaa ttgactaaaa tcatgaagga aactggtaag
    73741 agcttatcag agttggcggc agaagtaacg atttatccac aaaaattagt taatatccga
    73801 gtggaaaacg tcatgaagga aaaggccatg gaagtgccag ctatcaaggc catcatcgag
    73861 aagatggaag aagaaatggc ggggaacggc cgtatccttg ttcgtccaag tggaacagaa
    73921 cccctcttgc gtgttatggc agaagcgcct acaacagaag aagtagacta ctatgttgat
    73981 accatcacag atgtagttcg tgctgaaatt gggattgact aaatcctaga aaactagatg
    74041 aaaataaaaa attatggtac aatagcttat aatattgtag ccgatggaga aagacatgaa
    74101 tcttaaacgt gaacaagaat ttgttagtca gtatcatttt gatgcgcgta attttgaatg
    74161 ggaaaatgaa aatggagctc ctgaaaccaa ggtggatgtg aatttccaat tgctccaaca
    74221 tgaccaagaa aatcaagtga cttccttgat tgtcatcttg agctttatga ttgtatttga
    74281 taagtttgtc attagtggaa caatctcaca agtaaaccat atcgatggcc gtattgtcaa
    74341 tgaaccaagt gaattgaacc aagaagaggt ggaaaccttg gctcgtccat gtttgaacat
    74401 gctcaatcgt ttgacttacg aagtgactga aattgcatta gacttaccag gaattaattt
    74461 ggagttctaa tatgaaatta gctgttttca cagattcctc tgcttatctc agtgaagaga
    74521 ccttgcaaag agaagacttg tttgtcttgg atattcctgt caatattgat ggtgaggaat
    74581 atgtcgaagg catcaatctg tctgctgagg aattttacca aaaaatggct caggcttctg
    74641 aattgcctaa gaccagtcaa ccaagtattg ccaagttaga tgagatctta acttcgctca
    74701 aagaacaagg ctatacacat gccttggggc ttttcctatc ttctggaatt tcaggttttt
    74761 accaaaatat ccagtatatg gtcgatgact atgagggctt aaccattgct ttcccagaca
    74821 ctttgattac aagtgctccc ctaggcatca tggttgaaag cgtctttaat tggcgtgatc
    74881 agggcgatga ttttgccagc attcaggata agctagccat tcaaatcagc cgtacgtcag
    74941 cctttatcat ggtagatgac ttggatcatt tggtaaaagg tggacgcctt tcaaatgggg
    75001 ctgccatttt gggcaatttg cttagcatta agccaatcct ttattttaac gatcaaggtg
    75061 tgattgaagt ttacgaaaaa gttcgtactg aaaagaaggc caccaagcgc ttaattgaaa
    75121 ttatcaagga aacaacggct tcaggtcaat accgggtcat tgtcattcat gggaatgctc
    75181 ctgaaaaggc tgaagaattg cgtcagcact tgcttgattt tggcttgggt tcggatgttt
    75241 cacttgctac atttggtagt gtcattggaa cgcacctagg agcaggaagt attgctctgg
    75301 gttatattcc agtgatttag ttggcgcttc taggctagtt aagatgcctt gtatcttaga
    75361 aattgaacac ggactacctg cctcttgaaa aaagatgcct gtcttgcctt tcgtggaaag
    75421 tcagtgccat tccctatttt tcagaggcag ctaaggtcct ttgtatcttg ataattgaac
    75481 acgcctggaa ccctgtgtga aaaagatagt tcttccaaga agtagacact tcttgattgg
    75541 aattcctatt ttcactttgt gttcttacgg actttgtatc ttagacagga gtagagatga
    75601 gtattcgagt aattattgcc ggttttaagg gaaagatggg ccaggctgct tgtcagatgg
    75661 tattgactga tccagacttg gacttggtag cagttttgga tccttttgag tctgagtcag
    75721 aatggcaggg tattcctgtt ttcaaggata aggctgattt agctggtttt gaagcggatg
    75781 tctgggtaga ttttactact ccagctgttg cctacgaaaa tacacgtttt gctcttgaaa
    75841 atggctttgc tccagtagtt ggaacgactg gtttcacgag tgaagaaatt gcagagctaa
    75901 aagaattttc tcgtgcccaa gacttgggtg gcctgattgc ccctaacttt gccttgggtg
    75961 ctgtcttact catgcaattt gcgacgcagg ctgccaaata tttcccaaat gtggagatta
    76021 ttgagctcca tcatgacaag aaaaaggatg ctccgagtgg aacagccatt aaaacagctg
    76081 agttgatggc agaggttcga gagtccattc agcaaggcgc agcagatgag gaagagctga
    76141 ttgctggtgc tcgtggtgct gactttgatg gtatgcacat ccactcagtt cgtttgccag
    76201 gtttggtagc ccatcaggaa gtcatctttg gcaatcaggg agaagggttg accctccgtc
    76261 atgactccta tgatcgcatc tccttcatga caggagtcaa tttgggaatt aaagaagttg
    76321 tcaagcgtca tgagcttgtc tatggattag aacacttatt atgagattaa cgcaaatgcc
    76381 ttctgaattt cagaaggctt taccagtatt agaaaaaatt aaagaagcag gctttgaggc
    76441 ttattttgtt gggggctctg ttcgagatgc ccttctccat aaccctatcc acgatgtgga
    76501 tattgcgacg tcttcttatc cagaagagac caagcagatt tttccgcgaa cagccgatat
    76561 cggaatcgag catggaaccg tcttggtctt agatggggat gaggagtatg aggtaacaac
    76621 ctttcggaca gaggatgtct atgtggacta tcgcagaccc agtgcggttt cctttgtgcg
    76681 ctcgctagaa gaagacctca aacgccgtga tttcacagtc aacgcctttg ccttggatga
    76741 gacaggagaa atcgttgact tgttccatgg tttagaagat ttggaaaagc aagtcttgcg
    76801 agcagttgga gtggctagtg agcgtttcaa cgaagatgct ttacggatta tgcgtggttt
    76861 ccgttttcag gctagtcttg gttttgcact tgaaccagaa acatttaaag ctatgaagac
    76921 cttgacgccg cttttggaga acatttctgt agagcgtacc ttcgtcgagt ttgataaact
    76981 cttgctggct ccattttgga gaaggggctt ggcttccatg attgagagtc aagcttatga
    77041 ctatctccct gatatggcat ctagccagga caagctcaac agactgtttg atttggagac
    77101 tgattttact tttgaatcct ctgaacaagc ctgggcggct ttactatggg ctttggagat
    77161 tgaaaatgcg cagtcatttt tgaaatcttg gaagacctca cgccagtttg ccaagcaagt
    77221 tcaggatttg ctgattattt tggctctgcg tgaaaatgga gaattgagca agcgagattg
    77281 ttatcgcttt gacatagatt tgcttttaca ggctgaaaat cttcgtcaag ctcaaggaaa
    77341 agaagtcaac ccacaagcca tcacagaaaa ataccaaagc ttgactatcc atgacaagaa
    77401 agagattcag attaatggcg gtattttgat caaggaatat ggctatcagc caggcccaga
    77461 cttgggagag attttaacag agattgagtt tgccattgtc gatggagaat tggagaataa
    77521 tcgtgaagcc atccatgctt acctgaggga gaaaaaatga gtgattttat cgttgaaaaa
    77581 ctaagtaaat ccgttggtga caagaccgtt tttagggata tttcctttat tatccatgac
    77641 ttagacagaa ttggtttaat cggtgtcaat gggactggca agaccaccct tttggacgtc
    77701 ctttctggtg tttctggatt tgatggggat gtcagtcctt tttcagctaa aaatgattac
    77761 cagattggtt acttgactca ggatcctgat tttgatgata gaaagacagt tttggatacg
    77821 gttctatcta gtgaactcaa ggaaatccag ctcattcgtg agtatgaatt gattatgctc
    77881 gactatagtg aggacaagca ggcgcgtttg gaacgtgtca tggcagagat ggactctctc
    77941 caagcttggg aaatcgaaag tcaggtcaag accgttctta gcaaattggg cattcaagac
    78001 ttatctactc ctgttgggga attgtcaggt ggtctgagaa gacgggtaca gttggcacaa
    78061 gtcttacttg gcaaccacga cctcttgctt ttggatgagc cgaccaacca tctggatatt
    78121 gcgattattg agtggctgac cctctttttg aaaaattcta agaagaccgt cctttttatc
    78181 actcacgatc gttatttctt agacgctttg tcaacacgga ttttcgagtt ggatcgtgca
    78241 ggcttgaccg agtaccaggg aaattaccag gactatgttc gcctaaaggc ggaacaggat
    78301 gagcgcgacg cggctcttct tcacaaaaaa gaacaactct acaaacaaga attggcctgg
    78361 atgcgcagac aaccgcaggc gcgtgcgacc aagcagcagg cccgtatcaa tcgattccat
    78421 gatctgaaaa aggaagtttc aggcagtagt gctgagacag acttgaccat gaactttgaa
    78481 accagtcgga ttgggaagaa agtcatcgag tttcaggctg tttcctttgc ctatgaaaac
    78541 aagcctattt tgcaagattt taatctcttg gtgcaggcca aagaccgtat cggaatcgtt
    78601 ggggacaatg gtgttggaaa atcaaccctg ctcaacttga ttgcaggaag tcttgagcca
    78661 actaaaggac aagttgtgat tggggaaact gttcgcatcg cctatttctc tcagcaaatt
    78721 gagggtttgg atgaaagcaa gagagttatc aattacctgc aggaagtggc agaagaggtc
    78781 aagaccagtg gcggttctac gacttcgatt gcagagttgc tggagcagtt ccttttccca
    78841 cgttcgacgc atggaacctt gattgagaaa ttgtcagggg gtgagaaaaa acgtctttat
    78901 ctcctcaaac tgcttttgga aaaaccaaat gttcttcttt tagacgagcc aaccaatgac
    78961 ctagatattg caactttgac agtcttagag aatttcttgc aaggttttgc aggtcccgtt
    79021 ttaacagtca gtcacgaccg ctatttcttg gataaggtag cgaccaagat tctcgctttt
    79081 gaggatggca agattcgtcc tttctttggt cattacaccg actatcttga tgaaaaagct
    79141 tttgaaacag atatggccaa tcaagtgcaa aaggtcgaaa aggaaaaagt ggtcaaggtt
    79201 cgagaagaca agaaacgcat gacctaccaa gaaaagcagg agtgggcaag tattgaaggt
    79261 gatattgaaa ccttggaaaa acgtatcgct gctattgaag aggaaatgca ggctaacggc
    79321 tctgactttg gtaagctggc tactctccaa aaagaattgg atgagaaaaa tgaagcactc
    79381 cttgaaaaat acgaacgcta tgagtatctc agtgaatttg atagttaaga ctattcgaaa
    79441 atcaaagtgc aaactatgtc ggcttcacat tgccgactca agtacagcct gtgaccggct
    79501 tcctaatttg cactttgatt tttattgagt ataaacgaat agaaaaatcc cgtctcatga
    79561 aaggatttct ctattctttt ttggtttctt gatgaaagat attttgccag gtttcgtggc
    79621 gacgccagat actggtatgg atgataccat ctaactcata gcagataagt ttggtttttt
    79681 gactgatgga agtaatttga atgtccttga tagcagaatt taactctttt ttggtcttat
    79741 aagcctcttt atccatctgc tctccatctt ggcgaatata gacaaaatca tcagtcaaga
    79801 gttcttctag ttggtttcct tggtcgatca attgttcacg cataagcaat tttttataga
    79861 cattgtctaa aatttcatcc tcagggatag gtgctggttc gatatggaca tcggtatcaa
    79921 agacgccaaa acgctcctcc agcatagact cgacctgatc cgcgatttca tggctttcaa
    79981 aaacagacaa gtcaggattc atctctagtg taatatccag gtagatgttg ctaccgtagg
    80041 tgcgacctct ttgcgatttg accttgctga ttttgggaat ttccatgata gccttttggt
    80101 agtcctcgag caggcggtcg tcaaagccat ctgaaagact aaaggaagac tcgatgaaga
    80161 tatcataggc agtcttcaag ataaagaaag tgatgatgat agcaaccagt ttatccacaa
    80221 tcggataatt gaaactacta gctaggatgg caatggcggt tccaagtgag gtaacagcgt
    80281 cagaaagatt gtccttagca gctgccttca gcgccttgga gttggatttc ttactgaggc
    80341 gagtattgta gagatagacc acaaacataa tcgctgcaga aatgattcct agagttgcac
    80401 caagaggatc aatgaccgtt tcttcccgac tgagaatctt ttgaatggta tctcttagaa
    80461 catcgaaacc gacatagaac atgatgatag aagtgatcaa gcttgccaaa tcttcaatct
    80521 tccaatgacc aaaacggtgg tcacggtctg caggctggcg cgccatccga atcccgatta
    80581 agagggccac atttccaatg atgtccgata cgttattaaa accatcggcc accaaactgg
    80641 atgaatgaag gagatgacca gttgctaatt tggctgcaga caagatcaaa taggtcgaaa
    80701 tactgataat ggctccacgc tcagctaact tgagatttga gatagattgc ttcattcaac
    80761 ttcctttcta gtcacatagc attctaccat tatactggtt ttcaaggaaa aattcaaata
    80821 aggcagtttt tactctttga aaactcccca aaatttggta taatggtact actcaaggga
    80881 gtagctggca gaaacctgtg atagtgtcgt cattccgaat tttatgctga aaagtatgct
    80941 ttccggccct atcttaaaca gcgagacttg ttatgattaa caggtctctt tttgtttgtc
    81001 gtgaaaagat atgacagaaa gagagtctgt tttgcacaca atgtcaagga ggagacacat
    81061 gtcaaaagaa caaaaacgcc aagcgtttta tactcagagc cctgaagagg tcttgcaggc
    81121 tgtggatgcg accgagcaag gtttgtcatc aagtgaggcg gaaaagcgcc ttgccgaatt
    81181 tgggcacaat gaactcgaag aaggcgagaa acgatcaatc ttggtcaaat tcatcgagca
    81241 atttaaggat ttgatgatta tcatcctagt tgcggcagca atcttgtcag tcgtgacttc
    81301 tggtggggaa gatatcgcag atgccattat catcctagct gtggttatca tcaacgctgc
    81361 ctttggtgtt taccaagaag gaaaagctga agaagctatt gaagccctca aatccatgtc
    81421 tagtccagtt gcccgcgttc ttcgtgatgg acacatggca gagattgact ctaaagaatt
    81481 ggtaccaggc gatatcgttg cccttgaagc aggtgacgtg gtaccagcgg acctacgttt
    81541 gatagaagcc aactctctta aaattgaaga agcagccttg acaggtgaat ctgtaccagt
    81601 cgaaaaagac ttgtcagtcg agcttgcgac agatgctggt attggtgacc gtgtcaacat
    81661 ggccttccaa aactcaaacg taacctatgg tcgtgggatg ggtgttgttg tcaatacagg
    81721 tatgtacact gaagttggtc atattgctgg tatgcttcaa gatgcggatg agactgatac
    81781 accactcaaa caaaacttga acaacctttc taaggtcttg acctatgcta tcttggtcat
    81841 tgcccttgtt acttttgtag tgggtgtctt cattcaaggg aaaaatccac ttggtgagtt
    81901 gttgacttct gttgcccttg ccgttgcagc cattccagaa ggacttcctg ctatcgttac
    81961 catcgttctt tctcttggta ctcaagtttt ggccaaacga cattccatcg ttcgtaagtt
    82021 gccagcagtt gaaacacttg gttcaactga aatcatcgct tctgataaga ctggtacgct
    82081 gactatgaac aagatgacag tcgaaaaagt cttctacgat gcggttctac atgactcagc
    82141 tgatgatatt gaactaggtc ttgaaatgcc actacttcgt tcagttgtct tggccaatga
    82201 tacgaaaatc gatgtggaag gtaacttgat tggtgaccca accgaaacag cctttatcca
    82261 atatgccttg gacaagggct atgatgtcaa aggtttctta gagaaatatc ctcgtgtagc
    82321 tgaattgcca tttgactctg accgtaagct catgtcaaca gttcacccat tgccagatgg
    82381 tcgtttcctt gtagcagtca agggtgcgcc agaccaactc ttaaaacgtt gtcttcttcg
    82441 tgataaggct ggggatattg ctccgattga tgagaaggtt acaaatctca ttcatacaaa
    82501 caattctgaa atggctcatc aagccttgcg tgtccttgca ggtgcttata agattatcga
    82561 tagtattcca gaaaatctca cttctgaaga gcttgaaaat gatttaattt ttactggttt
    82621 gattgggatg attgaccctg aacgtcctga agccgctgag gctgttcgtg tggctaagga
    82681 agcgggaatc cgtccaatta tgattacagg tgaccaccaa gacacagcgg aagccattgc
    82741 caaacgtttg ggaatcattg acgcaaacga tacagaaggt cacgttttaa ctggtgctga
    82801 actcaatgaa ctgtcagatg aagaatttga aaaagtcgtt ggtcaatact ctgtttatgc
    82861 ccgtgtgtct ccagaacaca aggttcgtat cgtcaaggct tggcaaaaac aaggtaaagt
    82921 cgttgccatg acaggtgacg gtgtcaatga cgcgccagct ctgaaaacag ccgatatcgg
    82981 tatcggtatg ggaatcactg gtacagaggt ttctaagggg gcttctgaca tgattcttgc
    83041 agatgataac tttgcgacta ttatcgtcgc agtggaagaa ggacgtaagg tcttctcaaa
    83101 cattcaaaag actattcagt acctactttc tgctaatact gctgaagtat taaccatctt
    83161 cctatcaacc ttgtttggtt gggatgtctt gcagccggtt catcttttgt ggatcaactt
    83221 ggtaacggat accttcccag ctatcgctct tggtgttgaa cccgcggagc ctggtgtcat
    83281 gaatcataaa ccacgtggac gcaaggcaag cttcttctca ggtggtgttt tgagttctat
    83341 catttatcaa ggtgtactcc aagcagctct tgttatgagt gtttatggcc ttgcgattgc
    83401 ttacccagtt catgtgggtg acaatcatgc tattcatgca gatgccctaa cgatggcctt
    83461 tgcaaccctt ggtttgattc agctcttcca tgcctacaat gtcaagtctg tctaccaatc
    83521 catcttgaca gttggcccat tcaagtctaa gacctttaac tggtccatct tggtatcctt
    83581 tatccttctc atggcaataa tcgttgtaga accgcttgaa ggaatcttcc acgtaaccaa
    83641 actagacttg tcacaatggg gaattgttat ggctggaagc ttctcaatga ttatcatcgt
    83701 cgaaatcgtt aagtttattc aacgcaaact cggttttgac aagaatgcga tttaagggag
    83761 gtttcggatg tcagcatatc aattaccgac cgtatggcag gatgaagcta gtaatcaagg
    83821 agcttttacg gggctaaaca gacaaacagc aggtgcccgt ttcgaacaaa acttgccaaa
    83881 aggagaacaa gcttttcagc tttattcact gggaacacca aatggtgtga aggttactat
    83941 cttattggaa gaattactag aagctggttt taaggaagcg gcttacgact tgtataagat
    84001 tgctatcatg gatggggatc aattcggatc agactttgtg aagctcaatc caaattccaa
    84061 gattccagcc ttattggacc agtcaggtac tgaagatgta agagtctttg agtctgctca
    84121 tattcttctt taccttgctg agaaatttgg agccttttta ccaagtaatc ctgtggaaaa
    84181 ggtagaagtt ttgaattggc tattctggca agcaggtgca gcaccttttc taggtggggg
    84241 atttggacat ttcttcaatt atgctcctga aaaattggaa tatcctatta accgttttac
    84301 gatggaagtg aaacgccagt tggatttatt ggataaggaa ttggctcaga aaccttatat
    84361 tgcaggcaat gactatacga ttgcagatat tgctatctgg tcttggtatg gacagttagt
    84421 tcaagaaaat ctttaccaag gttctgcaaa attcttggat gcctcaagtt atcaaaatct
    84481 agtaaaatgg gcagaaaaaa ttgccaatcg tccagctgtt aagcgtggct tggaagtaac
    84541 ttatacagaa attaaatagc aaaaaagtca tcttcggatg gctttttgct acagttgagg
    84601 gaaagggttt gcagttatcg gcttttgtgc tataattgct ataatatagt aaaaagcaag
    84661 aggagtgtga ggaagtggaa aagaaaattg tgaaggataa cttattttta tctcaagtgt
    84721 ctcagccggc aagtcaggag gacctttatc ttgccagaga tttgcaggat acactcttag
    84781 caaatcgtga tacctgtgtt ggtctagctg ccaatatgat tggggtgcag aagcgcgtga
    84841 ttatctttaa tcttggcttg gttcccgtgg tcatgtttaa cccagtgctt ctgtcctttg
    84901 aaggatctta tgaggcagaa gaaggctgtt tgtccttggt aggtgtgaga tcaactaagc
    84961 gttatgaaac cataaggctt gcctatcgtg acagcaagtg gcaggaacag accattacct
    85021 tgacaggctt cccagctcag atttgccagc atgagctgga tcacttggaa ggacgaatca
    85081 tttaggagga aagcaaatga aacgaatagt ctttgaactt atttttatcg caacgacctg
    85141 gtatatcttt ttaccgcccc ttaacctgac cagctgggaa tttctcttct tcctctgtgg
    85201 gcatttgtta gttgtggcaa tcttatttgg ctttggcaag gggataaacc ttgtcaaaac
    85261 ggttcatgtg cgccacggta aggcggaagc tgccttaaat cttgagggtt tcaaaatcaa
    85321 tcggttaggg aaaattctgt tagcttcgat tggaggaatt cttctcttgg cagctttggt
    85381 ttccttggta acttccagca tgtttcaggc taaaaattat gccaatgtag tcacggttac
    85441 ggaaaaagac tttactgaat ttcctaggag tgacaccagt aaggttccta tcctagatag
    85501 aagtactgct gaaaaaattg gagaccgcta cttgggttcc ctaaccgata aggtgtcgca
    85561 atacgtagcg gcagatacct atacccaatt gacaattgat gggaaacctt atcgggtcac
    85621 accactagaa tatgcagacc ctatcaaatg gtttaacaat caagccaagg gaatcggtga
    85681 gtatatcaag gtggacatgg taactggaaa tgcggatttg gtggacttga agacaccaat
    85741 caagtattca gactcggagt attttaaccg tgatgtcaaa cgtcacctgc gcttgaagta
    85801 cccgaccaaa atctttaaaa ctccatcttt tgaggtggac gatgagggca atcctttcta
    85861 tgtagcaacg gtttaccaaa agcaatttgg acttgctgtt cctcgtcctg cttcagtcat
    85921 tatcttggat gctacaaatg gagaaaccaa ggaatacagc ttatcagatg ttccagaatg
    85981 ggtggacagg atctatccag cagaggaaac cattgagcaa attaactaca acggcaagta
    86041 caaggacggt ttcttgaatg ccatgatttc caagaaaaac gtgacccaga ctaccaaggg
    86101 ctataattac ttgtctatcg gtaatgacat ctatctctac acaggtgtga cgtcggctaa
    86161 tgcggatgag agtaatcttg gtttcatcct tgaaaatatg cgaacaggag aaatcactaa
    86221 gtatagcttg gcttctgcga cagaagaatc agcccgtgaa tcagcagaag gtgctgttca
    86281 ggagaaatcc tacaaagcaa ccttcccaat cctcatcaac ctcaatgaca agcctctcta
    86341 catcatgggc ttgaaggaca atgctggctt ggtcaaagag tacgccctgg tagacgcagt
    86401 cgagtaccaa aatgttatcg ttgctactac agtggaagag atgctcagca agtatgccaa
    86461 taaaaacgac cttgaaattg acaatgcaac gacagaaagc atcaatggag tagtagcaga
    86521 cctcaaatca gctgttatca agggagacac tgtctacttc tttaaagttg atggcaagat
    86581 atacaaggtc aaggcttcag tatccgatga ccttccttac cttgaaaatg gtaaaacctt
    86641 cgaaggtcaa gtaggaaaag acaattatct caagaccttt aagctacggt aaaaataggt
    86701 ttttttcaga aagtatatgt tataataagg taaattaagc ctaatggagg acaaagaaat
    86761 gggtttttat ttgatggttg cttcaatgct actcggactg ctcgctttga agataggttt
    86821 ttctcagttc aaggagaaaa aagataaatt cttatctatc ttaacaagtt tagctggcac
    86881 agcccttgtt ctcgtggctg tctggttagg atggcccaaa taaatagaaa aacctcggtc
    86941 aaaccgaggt ttttcaaatg aatttcttgg ttgtggctaa aaaatatgct acactatcaa
    87001 tatgaaaatt ttaatcccaa cagcaaaaga aatgaacaca gacttgccaa gtatcgaggc
    87061 aattccttta aaaccagaaa gtcagaccgt gcttgatgcc ttggctctct attctgccag
    87121 tcaattggag agtttctaca aggtatcagc tgagaaagcg gcggaagaat ttcaaaatat
    87181 ccaagctttg aaaaggcaaa ctgctcaaca ctatccagcc ttgaaacttt ttgatgggct
    87241 tatgtaccgc aacattaaga gagataagct gaccgaggcg gaacaagatt atcttgaaaa
    87301 tcatgtcttc attacctcgg ctttgtacgg tgttgttcca gccttgtcac ccatggctcc
    87361 tcaccgtttg gattttttga tgaaattaaa agtcgctggt aagactttga agagccattg
    87421 gaaggcagtc tatgatgaag ctctgaagaa ggaagaagtg attttctctc tcttgtcatc
    87481 agagtttgag actgtatttt ctaaggaaat cagagcaaag atggtgacct tcaaattcat
    87541 ggaggataga ggcggtcagc tgaagattca ctcaactatc tccaagaaag cgcgcggggc
    87601 ctttctaaca gctttaatag aaaatcaagt acaaactgtg ggggaagcac gtcgcttgaa
    87661 ctttgctgga tttgtttacc gagaagattt gtcacaacca cagggattgg tttttgtaaa
    87721 ggaagtatag aaatcagata ttttgtattt ggcaatatgt atcatcagct gttttagttt
    87781 ataaatgaga aaaaaagcga acaagctagt cttctgagtg tcagaaaagt agtcttgttc
    87841 gcttttatta tgttatactc ttcgaaaatc tcttcaagcc acgtcagcgt cgccttaccg
    87901 tatatatgtc actgacttcg tcagttctat ctacaacctc aaagcagtgc tttgagcagc
    87961 ttgcggctag cttcctagtt tgctttttga tttttattga gtgttagtta cttgatagct
    88021 tcgaccaagt cttgagcttg tttttcaagt gagtttagga ctgtttcttc aagaaccaat
    88081 tttccgtctg cccaggcaga gtcattaaca cgtgcagcag tgaaatcacc aacgccttgt
    88141 gtacggataa atggcaagag gtctttgtag atagcgaaaa gttgatcgtg ccctgcattg
    88201 gctacagatg atactgtgac aaacttgtct tgaagggcag aaacgccacg tgtatcagac
    88261 aagtcaaggg cacgagatag ccagtcaagc aagtttttca ctgtaccagg gatagagaag
    88321 ttgtagactg gagagaaaat ccagatagca tccgcaacga gaactgcttc acgagcggca
    88381 gctacagctg gatgtgttgg gacttccaaa tcttggctga agagagggag ggctgaataa
    88441 tcaaggtagc taacttccgc tttactagca agtgctttct cagcttcgag cgccatttgg
    88501 tggttgaaag aaccttgacg tagtgatccg acgataaata atactttttt agacatgatg
    88561 tgtctccttt ttcttaaaat ttcgagaact ctctcgttgt tataaaatat attacaacaa
    88621 aacaaaagaa cttgcaagaa atttgctcag agtttatttg aaaattgtaa aatttcggaa
    88681 actctagtca tttgtgactg aaaaagtaag aactgtttca ctttcaaaat cggttttgtt
    88741 tgaagggaga aatagaattg gttgctcaaa gcacagcttt gaggttgcag ataaagctga
    88801 cgtggtttga agagattttc gaagagtatt cttatattca cttgtaataa agcttaatag
    88861 atggtaaaat agacgagtga aaaaaagaca aaacaaagca aaaaataatc tactgtggca
    88921 gtatggtcta gggatgacga ttttgtttgt ggttatcagt ggttcctttc tgtatatggt
    88981 ttctcttagc atgaaaccct atcaaacagc taaaagtgaa ggagaaaaat tagctcagca
    89041 gtatgcagga ttagagcagg tcgatcaggt tgatttatac aatggcttgg aatcttatta
    89101 cagcgttctt ggtcgtaata aacagcaaga agcgcttgct gtcctgattg gtaaagatga
    89161 tcataagatt tacgtttatc agctaaatca gggtgtttca caagaaaaag cagaaacggt
    89221 ttctaaggaa aagggagctg gcgaaattga caagattatc tttggtcgtt atcaagataa
    89281 gccaatctgg gaagtcaagt caggatctga tttttatcta gtagattttg aaacaggagc
    89341 attggtcaac aaggagggcc tatggaatta tccaaccgtg ttttagaaat ggaagaaagt
    89401 gtgactttgg ctgctggagc ccgtgccaaa gcactgaagg ctgagggtag agatattttg
    89461 tctctaacct tgggtgagcc agatttcact actcccaaaa atatccaaga tgccgccatt
    89521 gcatcgattc gagatgggcg tgcttctttt tatacagtaa cctcaggtct gccagagctt
    89581 aaggcggcgg tcaatagcta ctttgagcgc ttttacggct attctgtagc gtcaaatcaa
    89641 gtgacagtcg ctgcgggagc caaatattct ctctatacct tctttatggc tgtggtcaat
    89701 ccaggtgatg aagtcatcat cccaacccca tactgggtta gctatggaga tcaggtcaag
    89761 atggcagaag gcgttcccgt ctttgtttct gctaaggaag acaatcactt taaggtgacc
    89821 gtagagcagt tagaagcagc tcgcactgac aagaccaagg ttttggtgct gaattcgcca
    89881 tctaatccca caggtatgat ttacacccgt gaggaactct tggcaattgg aaactgggct
    89941 gtagaaaatg atattctcat cctagcagat gatatctatg gccgcttggt ttataatggt
    90001 catgagttca caccgatttc tagcctatcg gaagcgattc gcaagcaaac agtggtcatc
    90061 aatggtgtgt ctaaaaccta tgccatgact ggttggcgga ttggttatgc cgttggagaa
    90121 gcagacatta tcgctgccat gtccaagatt gcaggtcaaa caacttcgaa tccgtcagca
    90181 gtagcccaat atgcagcagt tgaggctcta tcaggtgagc aagatactgt agaaagcatg
    90241 cgtcaggcct ttgaggaacg tcttaatacc atctatcccc tccttgcaga agtgccagga
    90301 tttgaagtgg tcaaaccgca aggggccttc tatctcttcc caaatgtcaa aaaggccatg
    90361 gagatgaaag gctacacgga tgtgacagac tttacaactg ttatcttaga agaagccgaa
    90421 gtggccttgg taacaggagc tggatttgga gcaccagaaa atgtccgcct cagctatgcg
    90481 acagacctag acacgcttaa agaagcagtc gaacgcttga aagcatttat gggtagtgag
    90541 aatgattgat cattttgaga ttaaggtaaa ggatttacaa atttcagaag gattttatag
    90601 gagttttctc gctcctttgg actataaatt ggcttttaag actagttctc taattagttt
    90661 tctatccccg aacagccctc atcctggtgg tgatttttgg ctgactcagg gaacacaaga
    90721 tcctgttcat tttgcttttt tagcagaaaa taaggaagaa gttcaggctt gttatgaggc
    90781 tggcttagag gcaggtgggc gagacaatgg ggctcctggt tatcgaagtg agcatccgat
    90841 ttactatgct gcttttgtga ttgacctgga tgggaacaat atagaggtgg tttgccataa
    90901 agaataaaaa agaaaaggaa aaataatgac aaaacgtgta acgattattg acgtaaaaga
    90961 ctatgttggt caggaagtga cgattggcgc ttgggttgcc aacaaatcag gaaaagggaa
    91021 aatcgctttc ttacaattgc gtgatggaac agccttcttt caaggtgtgg cttttaaacc
    91081 aaactttgtc gaaaaatttg gtgaagaagt gggacttgag aagtttgatg ttatcaaacg
    91141 cttgagccaa gaaacgtctg tttatgtgac aggtattgtc aaagaggacg aacgttctaa
    91201 atttggctat gagttggaca tcacagacat cgaagtgatc ggtgaatctc aagactaccc
    91261 aatcacacca aaagaacacg gaacagactt tttgatggat aaccgtcact tgtggctacg
    91321 ctctcgtaag caagtagctg tgttgcaaat ccgtaacgct attatctatg caacttatga
    91381 gttctttgac aagaacggtt ttatgaagtt tgacagccca attctttcag gaaatgcggc
    91441 agaagattct acagaactct ttgaaactga ctacttcgga acgccagcct acttgagcca
    91501 atcaggtcaa ctttacctag aagcaggggc tatggctctt ggtcgtgtct ttgactttgg
    91561 tccagttttc cgtgctgaaa aatcaaaaac acgccgtcac ttgactgagt tctggatgat
    91621 ggatgctgag tactcatact tgacacatga tgagtcgctt gacttgcaag aagcttatgt
    91681 gaaagctctt ctacaaggtg ttcttgaccg cgcgcctcaa gccttggaaa ccttggaacg
    91741 tgatacagaa ctcttgaaac gctacattgc agagccattc aaacgtatca cttacgatca
    91801 agccattgac ctcttgcaag agcatgaaaa tgatgaagat gctgactacg agcatcttga
    91861 gcatggtgat gactttgggt caccacacga aacttggatt tcaaaccact ttggtgtgcc
    91921 aacatttgtc atgaactatc cagcagccat caaggccttc tacatgaaac cagttcctgg
    91981 aaatccagag cgcgtgcttt gtgcagactt gcttgctcca gaaggctatg gagaaattat
    92041 cggtgggtct atgcgtgagg aagattacga tgcccttgtc gctaagatgg atgaacttgg
    92101 catggatcgt acagaatatg aattctacct tgaccttcgt aaatacggta cagttccaca
    92161 cggaggattt ggtatcggta tcgaacgtat ggtaaccttc gcagcaggaa caaaacatat
    92221 ccgtgaagct attccattcc cacgtatgtt gcaccgtatc aaaccataag aacaggaaaa
    92281 cgcccatgtg gcgttttttc gaattctagt gtttttactt gcgtaaaaaa attttttcta
    92341 gtataatagt ttattgtgag cgaacctcac ttaccccttg caaagtcttg gggtcattag
    92401 accaaaagga ggaacatatc aatggctaaa tacgaaattc tttatatcat tcgtccaaac
    92461 attgaagaag aagctaaaaa cgctttggta gcacgttttg actctatttt gactgacaac
    92521 ggtgcaactg ttgttgaatc aaaaacttgg gaaaaacgtc gtcttgcata cgaaatccaa
    92581 gatttccgtg aaggacttta ccacatcgtt aacgttgaag caaatgacga tgcagctctt
    92641 aaagagtttg accgtctttc aaaaatcaac gctgacattc ttcgtcacat gatcgtcaaa
    92701 attgacgcgt aagaaggtaa actatgatta acaatgttgt acttgtaggg cgtatgacac
    92761 gtgacgctga gttgcgttat accccatcaa atgtagcagt tgcgactttt actcttgcag
    92821 taaaccgtac atttaagagt caaaatggtg aacgtgaggc tgattttatc aatgtcgtta
    92881 tgtggcgcca acaggctgaa aatcttgcta actgggctaa aaaaggctca cttatcgggg
    92941 tgacaggtcg tatccagact cgtagttacg ataaccagca aggacaacgt gtctacgtga
    93001 cagaggtcgt ggctgagaat ttccaaatgt tggaaagccg tagtgtgcgt gagggccaca
    93061 caggtggagc ttactctgca ccaactgcaa actattcagc acctacaaat tcagtaccag
    93121 acttttcacg taatgaaaat ccatttggag caacaaaccc attggatatt tcagatgatg
    93181 atttaccatt ctaatggaca actaaactta taaaggagaa aaaacatggc tcaacaacgt
    93241 cgtggcggat tcaaacgccg taaaaaagtt gattacatcg cagcaaacaa aattgaatat
    93301 gttgattaca aagatactga gcttcttagc cgtttcgttt cagaacgtgg gaaaatcctt
    93361 cctcgtcgtg taacaggaac ttcagctaaa aaccaacgta aagtaacaac agctatcaaa
    93421 cgcgctcgcg taatggcttt gatgcctttc gtaaacgaag attaaagaaa agacccggtt
    93481 gggtctcttt ttcatgagct tgaaaacaag aaagcgaatt aagaccccaa cgggtctttt
    93541 ttcacaagct ttgaaatgag agagcgagtt aggctcagtg gctccctttt tacgagtttg
    93601 aaaacaagag aacacattaa aagcacgatg gagctttttc ataaatatgt cttttttctc
    93661 atccaagaaa ttaaaataaa aatgataaac tttttgaaaa taggggattt gcctacttta
    93721 tgatataatg gaaagagtta gattgaaaga ggtagtgaga tggacgcgaa attaagatac
    93781 aaggcaaaga agatcaagat tgtctttttt gatattgatg atacattgcg gaattcaaag
    93841 acagggttta ttccaactac aattcccact gtttttaaac agttgcgtga aaaaggaatt
    93901 ttaacaggaa tcgcctctgg acgtggcatt tttggtgttg ttccagagat tcgtgatctc
    93961 aagcctgact tttttgtaac tttgaatgga gcttatatcg aagataaaaa aggtcaggtc
    94021 atttatcagc atcagattga aaagtcagat gttgaggagt atatctcttg ggctaagcaa
    94081 gaaggaattg aatatggctt ggttgggagt catgatgcca agttgtcgac tcgcaccgat
    94141 atgatgagtg aagctatcaa tccaatttat cccgacttag atgtagatcc cgatttccat
    94201 gaaaaagaag atatctatca gatgtggact tttgaagata agggagatga cttgcacttg
    94261 cctgacagtc tctcagacaa acttcgcatg gttcgttggc atcaacattc gtctgatatt
    94321 gtgccgattt caggctccaa agcgacgggg gtggaaaagg ttgtggaaca ccttggcttg
    94381 aaaccagaga aggtcatggt ttttggagat ggtctcaacg acttggaact ctttgattat
    94441 gctggaatca gcgttgccat gggaatttct catgataaaa tcaaagaaaa agcagattat
    94501 attacaaaaa cattagaaga agatggcatt tttgatgcct tagaagtatt tggtatggta
    94561 gaaaaagaat tgcattttcc acaagtagac attgaaacag tagaaggtcc tcttgcgact
    94621 attaagacca atcacggaga cttacgtatc aagcttttcc ctgaacatgc tcctaaaaca
    94681 gtggctaact ttgtatctct ttcaaaagat ggctactatg atggtgtcat tttccaccgt
    94741 attatcaagg actttatgat ccaaggtgga gacccaactg gaactggtat gggtggcgag
    94801 tcaatctacg gcgaatcttt tgaggatgaa ttctcagaag agctttacaa tatccgtggt
    94861 gctctttcca tggcaaatgc tggtccaaat accaacggca gccagttctt tatcgtgcaa
    94921 aaccaacacc taccttattc gaagaaagaa attactcgtg gtggttggcc agaaccgatt
    94981 gcagaaatct atgccaatca aggtgggaca cctcacctag accgccgtca cacggttttt
    95041 ggtcagttag ctgatgaagc atcttacgct gtcttggatg ccattgctgc tgttgagaca
    95101 ggagctatgg acaagccagt tgaagatgtt gtaattgaaa ctattgaaat cgaggactaa
    95161 gatgaaaatc ggtgataagc taaaggggcg tattacaggg attcagccct acggtgcctt
    95221 tgttgagtta gagacgggtg atacggggct gattcacatt tcagaaattc ggacaggatt
    95281 tattgaaaat attcatgaaa ccttgaaagt cgatgaagag gttcaagttc aggtagtgga
    95341 tttagatgaa tttacgggga aagccagtct ttctatccgc actttggagg aagaaaagta
    95401 ccagtttcct agacggagac gcttttcaag cgaccgcttt aactacggtt ttgctccctt
    95461 tcgacgaatg ctaccaatct ggactggaga agccctgcac catttaaaaa agaagaagta
    95521 gtttagagtt ttatattttt tgtaatgtta atatgaattt gctataatag gaccatggaa
    95581 gaagaacaat tattaaaatc aggagagcgc attaaccagc tcttttcgac agatatcaaa
    95641 atcattcaaa atagagaggt ttttagctat tcggtggata gtgttctctt atcacgattt
    95701 ccacgttttc ctaagaaggg gttgattgtg gatttctgtg ctgggaatgg agcagtgggg
    95761 ctttttgcta gcactcgtac tcaagcacag atattgtctg ttgagattca ggagcgtttg
    95821 gcggatatgg ctgaacgctc tgtccgtttg aatggattag aggagcaaat gcaggtcatc
    95881 tgcgatgatt tgaaaaatat gcctgctcac attcagggga gtaaggtgga tatgattttg
    95941 tgtaatccac cctatttcaa ggtgaatcct tattctaatc tgaacgagag tgaacattat
    96001 ctcttggctc gacacgaaat cacgactaat ttggaagaaa tctgtcgtag tgcccagagt
    96061 attctcaagt ctaatgggcg tttggccatg gttcatcgtc ctgatcgact tctggatatt
    96121 ttggatacgt taaaacgaca taatctagcc cctaagcgcc tgcagtttgt ttatccaaaa
    96181 agagaaaagg aagccaatat gcttttgatt gaggcgatca aggatggctc aacaagtggc
    96241 tttaaggtct tacctccttt gattgtccac aatgatgatg gctcttatac gcccgaaatc
    96301 gaagagattt attatggatc ataaggctta tatgtacgtt ctggagtgtc gtgatggatc
    96361 ctactatata ggctatacga ctgatatgag aagacgcctc gctatccaca atagtgggaa
    96421 gggagccaaa tatacacgag cacgcttgcc agtcaaactt atctatgctc aaggttttgc
    96481 cagtaaggaa gaagccatgt cggctgaagc tcttctcaag cgtaagaaga ggccacagaa
    96541 ggaagaattt ttatctgaaa atcaagatag aaatttactc agttattttg aagaatcgtg
    96601 gggagtcctt tgactcctct tacctttgtc aaaaagcgaa aaaaatgcta caataaagaa
    96661 aataaacaaa atgaggtatt atcatgtcca agattctagt atttggtcac caaaatccag
    96721 actcagatgc catcggatca tctgtagctt ttgcctacct tgcaaaagaa gcttacggtt
    96781 tggatacgga agctgttgcc cttggaactc caaatgaaga aacagccttt gtcttgaact
    96841 attttggtgt ggaagcacca cgtgttatca cttctgccaa agcagagggg gcagagcaag
    96901 ttatcttgac tgaccacaat gaattccaac aatctgtatc agatatcgct gaagtagaag
    96961 tttacggtgt tgtagaccac caccgtgtgg ctaactttga aactgcaagc ccactttaca
    97021 tgcgtttgga gccagttgga tcagcgtctt caatcgttta ccgtatgttc aaagaacatg
    97081 gtgtagctgt gcctaaagag attgcaggtt tgatgctttc aggtttgatt tcagataccc
    97141 ttcttttgaa atcaccaaca acacacccaa cagataaaat cattgctcct gaattggctg
    97201 aattggctgg tgtgaacttg gaagaatatg gtttggcaat gttgaaagct ggtaccaact
    97261 tggctagcaa atctgctgaa gaattgattg atatcgatgc taagactttt gaactcaacg
    97321 gaaataatgt ccgtgttgcc caagtgaaca cagttgacat cgctgaagtt ttggaacgcc
    97381 aagcagaaat tgaagctgca atgcaagctg ccaacgaatc aaacggctac tctgactttg
    97441 tcttgatgat tacagatatc gtcaactcaa actcagaaat cttggctctt ggtgccaata
    97501 tggacaaggt cgaagcggct ttcaacttca aacttgaaaa caatcatgcc ttccttgctg
    97561 gtgccgtttc acgtaagaaa caagtggtac ctcaattgac tgaaagcttt aatgcgtaag
    97621 attttgggtg tcagctcaaa atcggaaagt ctagtttgcc ttatatcgaa aggagtttcg
    97681 gctccttttt tctaggagtg aagtatgtta gaaaatggcg atttgatttt tgtgagagat
    97741 gggtcagaca tgggacaggc catccagact tccacaggta actatagcca tgttgccatt
    97801 tatttggatg ggatgattta tcatgctagt ggacaggctg gtgttgtctg tcaagaaccg
    97861 gcagacttct ttgagtccaa tcatttatac gacctctatg tttacccaga aatggatatc
    97921 cagtcggtga aggaaagagc ttgcaaacat cttggagcac cctacaatgc ttctttctat
    97981 ccagatgcac ctggtttcta ctgctcccag tatatagcag aaatcctacc tatttttgaa
    98041 actattccta tgaaatttgg agatggggag caggagatta gtgatttttg gagggagtat
    98101 tacatagaac taggtctgcc tgttcctctg aaccaagctg gtaccaatcc tagtcagttg
    98161 gcagcatcgc ctctgttaca atgtaaagaa aggaatcttc atgattcaga tttttaatcc
    98221 atctcgtttg acgagacagc catttttgga gaattgatcc gctatctgga ccagtatgag
    98281 gatgtgattc tacgggaaat taaggctcaa tttccagatg ttgcagttga taaactcatg
    98341 gaagagtata taaaggcagg cttgattcta cgtgaaaata agcgctatta cctcaatttt
    98401 cctacgcttg aatcacttga tagtcttgaa ctggatcaag agatttttgt cagagaagct
    98461 agtccggtct atcaagcctt gttggagcag agttttgaga cggaattgcg caatcaaatc
    98521 aatgcagcta ttttagttga aaagacggac tttgcgcgca ttaaaatgac tctgtccaat
    98581 tatttttaca aggtcaaaca gcagtatcct ttgacagaaa aacagcagga gctctatgac
    98641 attttaggag atgttaatcc tgagtatgca ctcaagtata tgacggcttt tttgttgaaa
    98701 tttctcaaaa aagaccagct tatgcagaaa tgccgtgata tctttgtgga cagtttggtt
    98761 gtcttaggct atattgtgca aaatgaagat ggaaagtatg agttggctat cgattttgat
    98821 aaggagagat taactttcta cttagcgtga tttcttgttt ctgagtacat tgtttgactt
    98881 tccttagtat tcggtataaa ctatatgtaa ccggtaacac atatcggaat aaactaaagg
    98941 agacaatcat atgtcacttg aaaacaaatt ggaacaagca acaggcgctg tcaaagaagg
    99001 ttttggtaaa gttactggag acagcaagac agaacttgaa ggagctgttg aaaaaacagt
    99061 tgctaaggca aaagacgttg tagaagacgc aaaaggtgct gtagaaggtg ccgttgaagg
    99121 tttgaaaaac gtttttacta aagaatagga aaaaatcaag ggtttcattt tcccttgatt
    99181 ttttctattc ttataaataa ttttctgcga cggctgtatc tcctgggtag gattctttct
    99241 tgccctggat gatttggtaa caatcggctc ccttacccgc aataataact gcatctaatt
    99301 cgtgatttgt gatagccatt gccgccttga tggcttcttg gcgatccgca atcttctcaa
    99361 caggatgatt gatgtagcta ctaatttcat ctgcaatggc cattgggtct tcatagttag
    99421 ggtcatcagc agtcagaaag acttgaatct cagggtgttg attgaggagg aggccaaagt
    99481 ccttacgacg actttctccc ttgtttcctg ttgatcccag aaccagagca atctttccgg
    99541 tttgatgagt ttcaaccaca ttgatgagtt ttttcagact atccccattg tgggcatagt
    99601 cgatgaagac cttggctcca tttttctgag tgaggacttc catacgacca ggaacgcggg
    99661 ttgcagcgat gccttttttg atgtcctcaa gacttgctcc gagacggaga caagcaagtc
    99721 cagcagcaac tgcattttct tggttgaagt tgccaatgag ttggatatca taatctccag
    99781 cgagtttacc cgtagctgaa aagctaaagg ctttggaatt ctcgatttgg ttatcaaatt
    99841 ggctaccata gaaatcatgg tcttgatctt caacctgttc tttcaagact gagaagtggt
    99901 ccatgtcact gttaatgatg actgctcggc tattttccat caagagacgc ttgtggtaga
    99961 aatagtcttc aaagctaggg tgttcaatcg ggccgatatg gtctgggctg atattgagga
   100021 aaactcccac atcaaaggtt agaccataga cacgtctgac cagataggat tgactggaga
   100081 cttccatgat gaggtgggta cggtcatttt gcacagcctg attcatcatg tcaaagaggt
   100141 caatactctc aggggttgtc aacgctgact taaagaaagt ctcgccatca agagttgtgt
   100201 tcatggtcga caacatagca ggtcgatgcc cttgagataa gatgttatag gcgaaatagg
   100261 ctgctgttgt cttaccctta gtaccagtaa aggcaaggag tttgagtttt tcctgtggat
   100321 taccatagaa ctccatggca atcaaactca tggctttctt tatatcgttc acaatgatga
   100381 cagggatacc gacttcgtag tccttttcag ctacatacca agctaagcct tgtgttatag
   100441 cagaaagaag gtattctttt ttaaaggcag cgccttttgc aaaaaaaaga gtgtcttctg
   100501 ttacttttcg gctatcgtag ctgatgctat caaaaacaac tttgctgtag ttgtagtggt
   100561 aatgaccttg gtcaataatt tcgcgaaaaa ggccatcttt ctttaaaata tctaatacag
   100621 tttcaatttt tatcatactt tctattgtaa accgaaagtc gcaaatttac aagtaacaag
   100681 gaaaagttta taatggaaga taaggagttt ttcctagtta tcaaaattga atgaggaatc
   100741 tatgtcgcac gaaaacaatc accagcaggc ccagatgtta cgggggactg cttggctaac
   100801 ggctagtaac tttatcagtc gcctactcgg ggctgtttac attatccctt ggtacatctg
   100861 gatgggggct tatgcagcta aggcaaatgg tctctttacc atgggttaca atatctatgc
   100921 ttggttcttg ttggtttcaa cagcggggat tccagttgcg gtggccaagc aagttgccaa
   100981 gtataatacc atgcgagaag aagaggatag ctttgccctg attcggagct tcttaggctt
   101041 tatgacagga ctaggcctgg tttttgcttt agtcttgtat gtctttgctc cttggctagc
   101101 agacttgtct ggcgtgggca aagacttgat cccaatcatg caaagcttgg cttggggagt
   101161 cttgattttc ccgtctatga gtgttatccg aggatttttc caagggatga ataacctcaa
   101221 accttatgcc atgagccaaa ttgctgagca ggtcattcgt gttatctgga tgctcctagc
   101281 aacctttatc attatgaagc tcggttcagg agattatcta gcagccgtta cccaatcaac
   101341 ctttgctgcc tttgtcggta tggtagccag ttttgcagtc ttgatttatt tccttgccca
   101401 agaaggttca ctcaaaagag tctttgaaac aggagataag attaacagta agcgtctctt
   101461 ggttgatacc attaaggaag ccattccttt tatcctgaca gggtctgcca tccagctctt
   101521 ccagattttg gatcagctga cctttatcaa tagtatgagc tggtttacca actacagcaa
   101581 tgaggacttg gttgtcatgt tttcttattt ctcagccaat cctaataaaa tcacgatgat
   101641 tttgatttct gtaggggttt cgattgggag tgttggtttg ccacttttga cggaaaacta
   101701 tgtcaagggg gacttgaaag cagcttctcg tctggttcag gacagtctca ccctactctt
   101761 tatgttcttg ctaccagcaa cggttggagt ggttatggta ggagaacctc tatatacagt
   101821 cttctatggt aagccagata gtttggctct gggcttattt gtctttgcag ttttgcagtc
   101881 tattatttta ggcttgtaca tggtcttgtc tccaatgctt caggccatgt tccgcaaccg
   101941 caaggccgtt ctctatttta tctatggttc tattgccaag ctagtcttgc aactacctac
   102001 catcgccctc ttccacagtt atggtccttt gatttcaaca accattgctc tcatcattcc
   102061 taacgtcttg atgtatcggg atatttgtaa agtaactggt gtcaagcgca aggtgatttt
   102121 gaagcgaacc attttaatca gtttgctgac cctagtcatg tttctgttaa taggaaccat
   102181 ccagtggctg ttaggatttt tcttccaacc aagtggacgt ttgtggagct tcttttatgt
   102241 agctcttgtc ggtgccatgg ggggtggact ttatatggtt atgagtctgc gtacctattt
   102301 attagataag gtaataggaa aagcccaagc agatcgcctg cgagcaaaat ttaagctttc
   102361 gtaaggtagc atttataaat aaaaggaata agttgaacaa tcttttagga gaacttgaaa
   102421 cttattcctt ttttagcgtc aaaatagcta aaattatctt tcaaaaatag aaaatgaggt
   102481 ttttttgatt ttttggaaaa aacaattgac taaacaaacc aagagttgta taataaaaca
   102541 aatatttaaa gcaggaggtt ctggaaatga aaaagtctaa gagcaaatat ctaaccttgg
   102601 caggtcttgt cctgggtaca ggagttttat tgagcgcgtg tggaaattct agcactgcat
   102661 caaaaaccta taactatgtt tattcaagtg atccatctag tttgaactat ctagcagaaa
   102721 accgcgcagc aacatccgat attgttgcaa atttggtaga cgggttatta gaaaatgacc
   102781 aatatgggaa tattattcca tcattagcag aggattggac tgtttctcag gacggtttga
   102841 cctataccta caaacttcgt aaggatgcca agtggtttac ttctgaggga gaagaatatg
   102901 cgcctgtaac tgcccaggat tttgtgacag gtttgcaata tgcagctgat aaaaaatcag
   102961 aagctttgta tctagtgcag gactctgttg ctggtttgga tgactatatc actggtaaaa
   103021 caagcgactt ttcaactgtc ggtgtcaagg cacttgatga ccaaacggtt caatatactt
   103081 tggttaaacc agaactttac tggaattcaa aaacacttgc aacgatactt tttcctgtta
   103141 atgcagattt cctgaaatca aaaggggatg attttgggaa ggcggatcca tctagtattt
   103201 tgtacaatgg acctttcttg atgaaagcac ttgtctcaaa atctgctatt gaatataaga
   103261 aaaaccctaa ttactgggat gctaagaatg tctttgtaga cgatgtgaaa ttgacctact
   103321 atgatggtag cgaccaagaa tcactggaac gtaattttac agctggtgct tatactacgg
   103381 ctcgtctttt tcctaacagc tccagctatg aagggattaa agaaaaatac aaaaacaata
   103441 tcatctatag tatgcaaaat tcaacttcat atttctttaa ttttaaccta gataggaagt
   103501 cttacaatta tacttctaaa acaagtgaca ttgaaaagaa atcgactcag gaagcagttc
   103561 tcaataaaaa cttccgtcag gctatcaatt ttgcttttga cagaacatct tatggggctc
   103621 agtccgaagg gaaagaaggt gcaacaaaga ttttgcgtaa cctagtggtt cctccaaact
   103681 ttgtcagtat caagggaaaa gactttggtg aagttgtagc ctctaagatg gtcaactatg
   103741 gtaaggaatg gcaaggtatc aactttgcgg atggtcaaga cccttactac aatcctgaga
   103801 aagccaaggc taagtttgcg gaagctaaga aagaactcga agcaaagggt gttcaattcc
   103861 caatccactt ggataagact gtggaagtaa cagataaagt aggcatacaa ggagttagtt
   103921 ctatcaaaca atcaattgaa tctgttttag gttctgataa tgtagtgatt gacattcagc
   103981 aattaacatc agatgagttt gacagttcag gctactttgc tcaaacagct gctcagaaag
   104041 actatgattt atatcatggc ggttggggac ctgattatca agacccgtca acctatcttg
   104101 atatctttag tgtcaagaat ggtggggttc tacaaaatct tggactcgac cctggtgaag
   104161 ccaatgacaa ggctaaggca gttggacttg acacttatac tcaaatgttg gaagaggcta
   104221 ataaggagca agacccagcc aaacgttatg agaaatatgc tgatattcaa gcttggttga
   104281 ttgatagttc tttagttctt ccaagtgttt cgcgtggggg aacaccatca ttgagaagaa
   104341 ccgtaccatt tgctgctgcc tatggtttaa ccggtacaaa aggggttgaa tcatataaat
   104401 acctcaaagt acaagataag attgtcacaa cagacgaata tgcaaaagcc agagaaaaat
   104461 ggttgaaaga aaaagaagaa tccaataaaa aagcccaaga agaattggca aaacatgtca
   104521 aataaaatct aattgtagat aagtttgtgt aagaagtctt tgtgcttaaa aacgcataat
   104581 atcaggtata taaaatccta gatgttatgc gttttgttat aggaagattt attagatttt
   104641 atcctcaaat tgagttattc ccgactttat ccgttgaaat attataagga gtatttatga
   104701 aattaaaatt attaagagta gatactaagg tgattatggg gagtttctta cttgttctgt
   104761 ctagtctact tgctttgttg cttcccctta tcttaaaggg tttaatagat gggagttcta
   104821 ttgaaaatat aggttccaaa gtatttcaat cgtttttgat ttttattggt caagccttgt
   104881 tttcttctat tggttactat ctgtttagtc aatcgggtga aaaaaagata gcaaaaatca
   104941 ggaaaaaagt gatagagggg ttgatttatg cagagaaatc cttctttgat aagagccaaa
   105001 gtggggagtt gacttctgcc attgtcaatg acacgagtgt cattcgtgag tttttaatta
   105061 cgactttccc aaatattatt ctgagtttag ttatggtact tggttccatt gtagtcttat
   105121 ttagtcttga ttggaatctt tctctacttt tattcatcac tcttccttgt atgatgttta
   105181 ttatcttgcc cctttccaat atcagtgaaa agtatagtcg tcgtttacag gaggaaatcg
   105241 gatttttaac agggcaattg actgaaaaga ttcaagaaca tgaattaatt aagactaacc
   105301 aagcagagaa aagtgtacag gatgttttgg ataattgtat tgaaagggta caaaacaatt
   105361 cactgaaatc agatagggtt acttcttttg agaccccgtt tgctctctta tttatctttg
   105421 cgactatagc tgtgatgcta acctatgggg gttatcgggt cagcgcagga tatatatctg
   105481 tgggaacctt ggtttcgttt ttgatttacc tctttcaatt acttaatcct attagtaata
   105541 tagctaattt tgtaactgtt tattctagga gcaagggatc ttcagttgca ctggagaact
   105601 tgcttgcagt tcctaaagaa aaatttgagt gaggaaaatc ggtatcagga caagggttga
   105661 attttaacca tgtctatttt ggttatgatg aaaatcgacc tgtcttaaag gatattactt
   105721 gttcaatttt caaggggcaa aaaattgctt ttgttggacc atctggatca ggaaaatcaa
   105781 cgattgtgcg tttgttagag cagttttata aaccgctttc aggagatatt ctaatggagc
   105841 aatcaagtat atatgatttt aacttaaaag aatggagaag taaaatcgct tgggtttcac
   105901 aaaataatgc agtcttatct ggcagtattc gtgacaatct ttgtctcggt ttgaatcgct
   105961 tagtaactga tgatgaattg atgaaagtgc tagacttagt atcactaggt gatgagattc
   106021 gctccatgaa agagggacta gatactgaag ttggtgaacg cggacgattc ttgtcagggg
   106081 ggcaaagcca aagacttcaa atagctagaa cctacttaaa agatgctgaa attcttatat
   106141 ttgatgaagc tactgctaat cttgatgcgg attctgagta tgcgattatc agtagcctct
   106201 attctgtatt aaaggagaag acggttgtga ttatagcgca tagtttgtca acggtaaaag
   106261 atgtggattg tattttcttc ttagaggagg ggaaaatcac tggctcagga actcataagg
   106321 aactactgga aaatcatgag cgttatgctc gttttgtgca ggagcaaatg atagagtgaa
   106381 gtgtcttttg agattcacca ttttatagtc tattaaaggg agcaggaaaa actccctttt
   106441 tatatagttt gaaactataa ctagctcttg aaaagaagaa aatgagttga tgaaaataag
   106501 tggtacaata gttactatag atttggaggt attgtatgag caaggaatta cacattaaca
   106561 caattttggc ccaggcgggt attaagtcag atgaagcgac aggtgcattg gtgacaccgc
   106621 ttcatttttc aacgacctat cagcatccag agtttggtcg atctactggg tttgactata
   106681 cgcgcactaa aaatccaact cgtagtaagg ctgaggaagt cttggcgact attgagtcag
   106741 cagactatgc cttagcgact agctcaggga tgtcagctat tgtactggcc tttagcggct
   106801 ttccagtagg aagtaaggtc ttggcagtgc gtgatcttta cggcggttct tttcgctggt
   106861 ttaaccaagt ggagcaggaa ggtcgtttcc attttaccta tgccaataca gaagaagagt
   106921 tgattgccga gttagaaaag gatgtggatg ttctctatat cgaaacccca accaatccct
   106981 tgatgttgga atttgatatc gaaaaactag caaaattggc tcatgctaag ggtgccaaag
   107041 tggtggtgga caataccttc tatagcccta tctaccaacg tccgattgaa gatggagcag
   107101 atatcgttct ccattcagca accaagtatc tagcaggcca caatgatgtc ttggctggag
   107161 tggttgtgac caatagttta gaactatacg agaagctttt ttacaatctc aatacaacag
   107221 gggcagtctt gtctccattt gacagctacc agttgcttcg tggtctcaag accttgtctc
   107281 ttcgtatgga gcgctcaaca gctaacgccc aagaagtggt tgcctttttg aaggattctc
   107341 cagcagttaa ggaagttctc tacactggtc gtggaggcat gatttccttt aaagtagccg
   107401 atgaaacacg cattcctcat attttgaaca gtctcaaggt cttctctttt gcggaaagtt
   107461 tgggcggagt ggaaagtctt attacttatc caacgactca aactcatgct gatattccag
   107521 cagaagtacg ccattcttat ggtttgacag atgacctctt gcgtttgtct attgggattg
   107581 aggatgctag agatttgatt gcagatttgc gccaagcctt agaaggataa gacaaagatg
   107641 ggaaaatatg attttacaag cctgcccaac cgtttagggc accataccta taaatggaaa
   107701 gaaacagaaa cggatagtga agttctacca gcttggatag cggatatgga ctttgtggtc
   107761 ttgcctgaaa tccgccaagt cgtgcaaact tacgcagacc aactggttta tggttatacc
   107821 tatgccagtg aagacttaat taaggaagtt caaaagtggg aagctacaca atacggttac
   107881 aactttgaca aagaggctct tgtctttatc gagggtgtgg taccagccat ctcaacagct
   107941 attcaaacct ttacaaaaga aggcgatgcg gttttaatta acacgcctgt ctacccaccc
   108001 tttgctcgca gtgtcaagtt gaataatcgt agattgatta ctaattcctt agtggaaaag
   108061 gatggtctgt ttgagattga ctttgaccaa cttgaaaagg atttggtgga agaggaggtt
   108121 aaactctata ttctttgcaa ccctcacaat cctggtggac gtgtttggga aaaagaagtg
   108181 ttggagaaga ttggccaact ctgccaaaaa cacggtgttt tgttagtttc ggatgagatt
   108241 caccaagatt tgaccctctt tggtcacaaa caccagtctt tcaataccat caatcctgcc
   108301 ttcaaaaatt ttgctatcgt cttgagcagt gccactaaaa catttaatat tgctggaaca
   108361 aaaaattcct atgcagtcat tgaaaatcct aagttgagac tagctttcca gaaacgcctg
   108421 ttggccaata atcagcatga aatttcaggc ttgggttatt tggcgacaga agctgcctat
   108481 cgatacggta aagattggct agaggaactc aagcaagtct ttgaagacca catcaattat
   108541 gtggtggatc tatttggaaa agagactaaa atcaaggtca tgaaaccgca aggtacctac
   108601 ttgatttggc ttgacttttc agcctatgac ctgactgatg aaacattgca agagttgttg
   108661 agaaatgaag ccaaggttat cctcaaccgt ggtttggatt ttggagagga aggaagtctc
   108721 catgcccgca tcaatatagc tatgcccaaa tctctgttgc aagaagtctg tcagcggatt
   108781 gtggctactt ttgccaaacg ttaaaaatcc agccttctag gagaaaagtc ttcctagaag
   108841 gctattttca taggcgaaaa tatggtataa taaaaagata aggtaaaggt gaaaatatgg
   108901 ctaaattgat tccggggaaa attcgtatcg aaggtgttgc cctttatgaa actggtaagg
   108961 ttgatatcat caaggaaaag aacaatcggc tctacgctcg cgttgcagaa gaagaactgc
   109021 gctatagttt agaggatgat ttggtttttt gtgcctgtga tttttttcaa aagaggggtt
   109081 actgtgtgca tttggcagcg ctagagcatt ttctgaaaaa tgatgagcgt ggtcaggaaa
   109141 tcttgtggag tctggaagaa ggtcatgaag aaaaagaggc tgttgaaacc aaggtgacct
   109201 tgggtggcaa gtttttggat cgaattttat ctccaaaatc agaatgcgcc tatgagttat
   109261 cagctgtggg tcaggtggaa gcaggaacca atcatatctt gtggactctg agaatcggcc
   109321 aaatcaatag ccaaaaatac tatgtcattc gggatattcc acttttttta aggattgtcg
   109381 agcagagaaa gtcgtatatg attggcaaga tttatgagga gtctctttct tgggaagcct
   109441 ttgatgatgc cagccaagaa cttttgactt tcttgcacgg actaacggag gaagggctgg
   109501 tttcagacct ctttttccaa aaccaaggtc ggcacctctt tttccctctg accttttttg
   109561 agcagggtgt gaatttactg atggccttgc cccattttca atttgaccat caagtggata
   109621 gctaccaaac cctgcttttt caggatatgc atgctgatgc caatctattt gcctttacag
   109681 taacagaata ctcggactat tttgaaatgg aaatcagtga gagtcctagg gtcaatgtct
   109741 tttatcaggg agcagtactt ttccataaag gtcaggttta ttttttaaca gaccagcaga
   109801 tgcgtcttct caaggaaatt aaagcgttac ctgtgggtca acaaggaaag aaatacctgc
   109861 aatttgatag cagtgatcga gacaaattgg cctcctgtct gactcttttt atccagatgg
   109921 gcaccgtttc agctccagaa cgtctacaaa tcaaaacttt tgcgccctct ttttactttg
   109981 acagggaaga agataatcgg attcgtttag aaattcagtt tgattatgga aatagacagg
   110041 tatctagccg acaagagcta gaagaattac cattttcaag tgacgcggac ttagaagaaa
   110101 gaattttcca agtctgtttg gctgcgggct ttgaggccga ttttcaatct tggcgtcagg
   110161 ccttaaaagc ggagtctgtc tatcattttt ttcatgatat cattccagtc tttgaaaaac
   110221 tcgggcatgt tgacctatca gataaactag aagagcttta tagcctagcg agtcctcagg
   110281 tgcagattgc ctccaaggga ggtctcttgg aaatccagtt tgattttcaa aatattgtcc
   110341 aggaggaaat cgaccaagcc atgcaggcct tggttgccaa tcaggatttt tatattgatt
   110401 cgtctaatca agtttacttt ttcgatgaag aaaccaagaa aattcgccaa aatttacagg
   110461 aactggggca atttgaatta aaagatggga ccttgcaggc tcggaaatcc ttgacctaca
   110521 gtttagctca tctctttgaa gggcgagacc gtgtttcttt ttcacaagaa ttccagaatc
   110581 tggcccagga tttgacgcat ccagaggact ttcctttgca agcaactcag gtcaaggctg
   110641 acttgcgaga ttatcaggaa aagggaattg gctggttgca gatgctccat cattatggtt
   110701 ttggtgggat tttggctgat gatatgggac ttgggaaaac ccttcagacc attgcttttt
   110761 tgactagtca agtgacaaaa gaaagtcggg ttttgattct cgctccgtcg ggtttgattt
   110821 acaactgggc agatgagttt cagaaatttg ctccacagtt ggatgtgact gttgttcatg
   110881 gtttgaaagc aagtcgtgag gagattcttg ccgagagcca tcaaatctat gtgactagct
   110941 atgccacctt ccgtcaggac agtgagcttt atcaggggat ggcctttgac ttccttttct
   111001 tagatgaagc tcaggtcatg aaaaatgccc agaccaagat tgcccagacc ttgagacaat
   111061 ttgtggtgcc gtcggtcttt gccttgtcag gaactccgat tgaaaaccat ctgggtgagt
   111121 tgtggtctat tttccaaatc gtcatgcccg gacttttgcc aagcaagaaa gaatttatga
   111181 aattgccagc agagcgagtg gctcagttta tcaagccttt cgtgatgcga cgcaagaaag
   111241 aagaagttct gactgaattg ccagacttga ttgaggtggt ttataaaaat gaactggaag
   111301 accagcaaaa ggctatttac cttgcccagt tacaacagat gcgagaccat ctggctcaag
   111361 tgtcagaaca ggaatttcag cgaagtcgtg tggaaatttt atctggtttg atgcgcttgc
   111421 gtcaaatatg tgacactcct gccctgttta tggaagatta tcagggagcc agcggcaaac
   111481 tagatagtct ccgagaccta ctggtacagg tggcagacgg cggacaccgt gtcttgattt
   111541 tctctcagtt caagggaatg ttggaaaaaa ttgaacaaga actgccagac ttgggcctga
   111601 cttcctttaa aattacgggt tcaaccccag ccaaggaaag acaagacatg accaaggcct
   111661 ttaaccaagg agaaagagat gcctttctga tttccctcaa ggctggtggg gtcggtctga
   111721 acctgacagg tgcagataca gtgatcttgg ttgacctttg gtggaatcct gcggtggaag
   111781 cgcaagccat tggccgtgcc catcggatgg gtcaggaaga aacggttgag gtctatcgct
   111841 tggtgaccaa gggaaccatt gaagaaaaaa ttcaggaact ccaagaacaa aagaaacatc
   111901 tggtgtcaca agtattggac ggcacagagt cacgtggtag tctgacccta gcagaaatta
   111961 gagaaatttt gggaatttct gaagccagca cttgaaaaat caagacaata cgctataatg
   112021 aagtgttgaa aggaaataga aaatgaaaca agaacgattt ccattggtgt cagatgacga
   112081 ggtcatgttg actgaaatgc cagtcatgaa tctctatgat gagtctgatc tgatcagtaa
   112141 tatcaagggt gagtatcgag ataaaaatta tttagaatgg gctcctattg ctgaagaaaa
   112201 accagtaaaa ccgattgaaa agcaagtcga aaaacctaaa aaggctcctt taggggttaa
   112261 aaaagaagga aagagctatg cggaggtggc gcgtgaagaa gcgcgtgcgg acttgaaaaa
   112321 gaaacgctct gctaactacc taactcagga tttcagcctt gcgagacgtc attctcagcc
   112381 cagtctagtt agacagggca atcaaccgac aactcctttc caaaaggaaa atcctggtga
   112441 atttgtcaaa tatagccaaa aattgaccca gtctcattat atcttggcgg aagaagttca
   112501 ttctatccct accaagaatg aagaagtgtc agcacctgct ccaaagaaaa acaattatga
   112561 ttttctaaag aagagccaaa tctacaataa aaaaagtaaa caaacagaac aagaacgtcg
   112621 ggttgcccaa gagttgaatc tgaccagaat gacagaatag gggagaaaac atgtcaaaga
   112681 catatcattt tatcggaatt aagggatcag ggatgagtgc cttggccttg atgttgcacc
   112741 agatggggca caaggttcag ggatcagatg ttgaaaagta ctactttacc caacgcggtc
   112801 ttgagcaggc aggaattacc attcttcctt ttgatgaaaa gaatctagac ggtgatatgg
   112861 aaattatcgc tggaaatgcc tttcgtccag ataacaacgt cgaaattgcc tatgcggacc
   112921 aaaatggtat cagctacaaa cgttaccatg agtttctagg tagctttatg cgtgactttg
   112981 ttagcatggg agtagcagga gcacatggaa aaacttcaac gacaggtatg ttgtctcatg
   113041 tcttgtctca cattacagat accagcttct tgattggaga tgggacaggt cgtggttcgg
   113101 ctaatgccaa atattttgtc tttgaatctg acgaatatga gcgtcacttc atgccttacc
   113161 acccagaata ctctattatc accaacattg actttgacca tccagattat ttcacaagtc
   113221 tcgaggatgt tttcaatgcc tttaacgact atgccaaaca aattaccaag ggtctttttg
   113281 tctatggtga agatgctgaa ttgcgtaaga ttacgtctga tgcaccaatt tattattatg
   113341 gttttgaagc tgaaggcaat gactttgtag ctagtgatct tcttcgttca acaactggtt
   113401 caaccttcac cgttcatttc cgtggacaaa acttggggca attccacatt ccaacctttg
   113461 gtcgtcacaa tatcatgaat gcgacagccg ttattggtct tctttacaca gcaggatttg
   113521 atttgaactt ggtgcgtgag cacttgaaaa catttgccgg tgttaaacgt cgtttcactg
   113581 agaaaattgt caatgataca gtgattattg atgactttgc ccatcatcca acagaaatta
   113641 ttgcgacctt ggatgcggct cgtcagaaat acccaagcaa ggaaattgta gcagtctttc
   113701 aaccgcatac ctttacaaga accattgccc tgttggacga ctttgcccat gctttaaacc
   113761 aagcagatgc tgtttatcta gcgcaaattt atggctcggc tcgtgaagta gatcatggtg
   113821 acgttaaggt agaagaccta gccaataaaa tcaacaaaaa acaccaagtg attactgttg
   113881 aaaatgtttc tccactccta gaccatgaca atgctgttta cgtctttatg ggagcaggag
   113941 acatccaaac ctatgaatac tcatttgagc gtctcttgtc taacttgaca agcaatgttc
   114001 aataggatgt tcccatggaa attccaatta agatcattca ggcaagcaag tttgatttgc
   114061 ctgagatagg ggcacttcag acctcgtctt ttccagctga aaagcagcaa ctttcccata
   114121 ttttagaaga aagtatccgt aagtgtgcgg atacctttct tctagctagg gatgaaaatc
   114181 aacttttagg ctatatttta tcaagtcccc agtcagacaa tccgcaatgt ctaaaagtac
   114241 attctttagt catcgagtct gaccatcaga gacagggcct gggaacactt cttcttgcag
   114301 ccttgaaaga ggtggcagtt gagctggatt acaaagggat tcgtttggag agtcctgatg
   114361 agctgctttc ctattttgaa atgaacggtt ttgttgatga agaagaaatt ttgctctatg
   114421 caactagcca gggctatagt atgatttggt ttaatccctt ttatctggag gaacaatgaa
   114481 aatcagacaa gcaagattag aagatttgga tcggattgtt gaacttgaat ttgaaaattt
   114541 ttcggtcgaa gaagccattc ctccttctgt ctttgaagca catttgagag aaattcagac
   114601 ctcttttctg gttgctgaaa aagaaggaag aatcatgggt tatatcgaag gaccagttgg
   114661 cctgcaccgc catctgcaag accagtcttt tacagaagaa ataaaagact atagtcatga
   114721 gcctggtggt tatatctctg tgacctgtct gtctattgcc aaggaggcac agggactcgg
   114781 actgggtcag aaattgctga cagccttgaa agaagttgct cttgaagatg agagagatgg
   114841 cattaatcta acctgtcatg actatctcat cgcctattat gaaaaacatg gatttgtcaa
   114901 cgaaggccag tcccagtcaa cctttgcagg ggaaacatgg tatgatatgg tctgggaaat
   114961 gaaaaaataa gttaggaaaa gtatcataga ttgctttttt tggactttta agatataata
   115021 ttatggatta tcaacaagga ggaaaaactt ttgagtgaaa agtcaagaga agaagagaaa
   115081 ttaagcttta aagagcagat tctgagagat ttagaaaaag taaaaggcta tgatgaagtt
   115141 ctgaaagaag atgaggcagt agttcgcact cctgcaaatg aaccttcagc tgaagaactc
   115201 atggctgatt ccttgtcaac ggtagaggag attatgagaa aagctcctac cgtgcctact
   115261 cacccaagtc aaggtgtacc agcttctcca gcagatgaga ttcaaagaga aactcctggt
   115321 gttccaagtc atccaagtca agatgtacct tcttctccag cggaagaaag tggatcaaga
   115381 ccaggtccag gtcctgttag acctaagaaa cttgaaagag aatacaatga aaccccaaca
   115441 agggtagctg tttcctatac gacggcagag aaaaaagcag aacaagcagg tccagaaaca
   115501 cctacgcctg ctacagaaac agtggatatc atcagagata catcacgtcg tagccgtaga
   115561 gaaggagcaa aacccgttaa gcctaagaaa gagaagaagt cacatgtgaa agcttttgtg
   115621 atttcattcc ttgtattcct tgccttgctc tcagcaggtg gttactttgg ttaccagtac
   115681 gtgctagatt ccttattacc tatcgatgct aattctaaga aatatgtgac ggttggaatt
   115741 ccagaaggtt caaacgttca agaaatcggt acgacgcttg aaaaagctgg tttggtaaag
   115801 catggtctga tttttagttt ttatgccaag tataaaaatt ataccgactt gaaagcaggt
   115861 tactacaatt tgcaaaagag tatgagtaca gaagacttac tcaaagagtt gcaaaaaggt
   115921 ggaacagatg aaccgcaaga acctgtactt gcgactttga caattccaga aggttatacc
   115981 ttggatcaga ttgctcaaac tgtgggtcaa ttgcaaggtg acttcaaaga gtctttgaca
   116041 gcggaggctt tcttggctaa agttcaagat gagacgttta tcagtcaagc agtagcgaaa
   116101 tatcctactt tactggaaag tttgcctgta aaagacagcg gtgcgcgtta tcgtttggaa
   116161 ggataccttt tcccagctac atactctatc aaggaaagca caactattga gagcttgatt
   116221 gatgagatgt tagctgctat ggataagaac ctatctcctt actatagtac tatcaaatct
   116281 aaaaacttga ctgtcaatga gttgttgacc attgcttcct tggtcgaaaa agaaggtgcc
   116341 aagacagaag atcgtaagct cattgcaggt gtattctaca atcgtttgaa tcgtgatatg
   116401 ccacttcaaa gtaatattgc aatcttgtat gcccaaggaa aactggggca aaatatcagt
   116461 ctagctgagg atgttgcgat tgataccaac attgattcac cttataatgt ttataaaaat
   116521 gtaggtctca tgcctggtcc agtcgatagt ccaagtctgg atgcgattga gtcaagcatc
   116581 aatcaaacta agagcgataa cctctacttt gtagcagatg tcacagaagg caaggtctac
   116641 tatgctaaca atcaagaaga ccacgaccgc aatgtcgctg aacatgtcaa cagcaaatta
   116701 aactaaacaa actaaaatta tgtgatactt cacataattt tctttagaaa atattatcag
   116761 aagaaagttg agaaaaatgg cagaaaaaac atatcctatg acccttgagg aaaaggagaa
   116821 acttgaaaaa gaattagaag aattgaaatt ggttcgtcga ccagaagtgg tagaacgcat
   116881 taagattgcc cgttcatacg gtgatctttc agaaaacagt gagtacgaag cagctaagga
   116941 tgaacaagcc tttgtcgaag gacaaatctc tagcttagaa acaaaaatcc gctatgctga
   117001 aatcgtcaat agcgacgcag ttgcccagga cgaagtagcg attggtaaaa cagtcaccat
   117061 ccaagaaatt ggtgaggacg aagaagaagt ttatattatc gtaggttcag ctggtgcgga
   117121 tgcctttgca ggtaaggttt caaatgaaag cccaattggg caggccttga ttggcaagaa
   117181 aacaggtgac acagcaacca ttgaaacgcc tgttggtagc tatgatgtaa aaatcttgaa
   117241 ggttgaaaaa acagcctaaa aacagaaaaa ggagtgggga ggcgatgtgc ttcactcact
   117301 cctttttcca ttttgctatt cttcgaaaat ctcttcaaac cacgtcagcg tcgccttgcc
   117361 gtatgtatgg ttactgactt tgtcagtttc atttacaacc tcaaaacagt gttttgagct
   117421 aacttcgtca gtttcatcta caacctcaaa acagtgtttt gagctaactt cgtcagtttc
   117481 atctacaacc tcaaaactat gttttgagct gacttcgtca gtttcatcta caacctcaaa
   117541 acagtgtttt gagctaactt cgtcagtttc atctacaacc tcaaaacagt gttttgagct
   117601 gacttcgtca gtttcatcta caacctcaaa accatgtttt gagctgactt cgtcagtttc
   117661 atctacaacc tcaaaaccat gttttgagct gacttcgtca gttctatcta caacctcaaa
   117721 acagtgtttt gagcaacctg cggctagttt cctagtttgc tctttgattt tcattgagta
   117781 ttagatgtat agtgcattga agttaaaata gtaaactttg atttctaaga cattattaga
   117841 aattagatta aattccttaa tcgatttgcg catgttttat ttcatttcat tatactttag
   117901 attggaaaat aaggaatcac ataaatcgca agaaataggg aatctgattc gtgtttataa
   117961 ccgttcaaaa agggaagagg ctgaaagtga gccacttaat ctttatgtcg aagatgaaaa
   118021 gggcaatctc cttgcgggtt tgatagcaga gacttttgga aattggctag aaatcgagta
   118081 tttgtttgta aaagaggaac tgcgagggca aggaatcggt tcaaaactat tgcaacaggc
   118141 agaaagtgaa gctaagaatc gaaattgttg ttttgccttt gtcaatactt atcagttcca
   118201 ggcaccggac ttttatcaga aacatggcta caaggaagtt ttttatttgc aagactatct
   118261 ctacattagg caaagatatt attaccaaaa gaatctgtaa ggtgagtatg gaggtataat
   118321 acaaagagag gctcgcacat aagtatggag gtggactgat gtatatgagt aactatcgat
   118381 aaataccagt tataacctag aaattgtgtc tttctagacg atattgagga caatataatc
   118441 gtagctccaa aattaggaat caaggcttat caggttaaga aaagaagtga tgttgttgat
   118501 attttaaaac aatttattta aactaaaaac tctctatctt tttaaattga cattaatccg
   118561 agattcccct ctcggatttt gtgttgcttt cattaaattt acaggtaaga cttgctagct
   118621 tcagtaaata tacacaagtt tttcagaata gagtgaaatc cgaaagaaaa tggaaataat
   118681 gaaagctctt gtaggcataa gaaaacacct ctgtgttata cttgttgttc aaccacaaac
   118741 acaagaaagg cacagagatg caaaaccatt atactacaaa aggcgaacat ttgacaatcg
   118801 atagccgtcg cttaatcgaa agatggaaaa aagaagggaa atcaaataga gaaattgcct
   118861 ctctgcttgg aaaagttcct caaactatcc acactgaaat caagcgtggg acagtccgac
   118921 aatgtcttgg aaaagggcgc ttcaaagagg tttattctgc cgactatgct caacagtctt
   118981 atgaaaacaa tcgcaagcgc tcggtcaaga aatcaagctt gaccaaggaa ctaaaggaaa
   119041 agattctcca ctatcataac caaaaatttt cgcctgaaat gatggtgatg g
//
LOCUS       DBMVGT010000002        94519 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.002, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000002 DBMVGT010000000
VERSION     DBMVGT010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 94519)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 94519)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..94519
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.002"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            1..166
                     /locus_tag="AC0DU4_000123"
                     /pseudo
     CDS             1..166
                     /locus_tag="AC0DU4_000123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            136..1149
                     /locus_tag="AC0DU4_000124"
                     /pseudo
     CDS             136..1149
                     /locus_tag="AC0DU4_000124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259617.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004601 - peroxidase activity [Evidence
                     IEA];
                     GO_function: GO:0020037 - heme binding [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Dyp-type peroxidase"
     gene            1124..1702
                     /locus_tag="AC0DU4_000125"
     CDS             1124..1702
                     /locus_tag="AC0DU4_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron permease"
                     /protein_id="HIN4236171.1"
                     /translation="MVRNYWKAKSWLLVLALSFLILSPAGAQESLSFFFVKITDASKT
                     VKNGGQTETQKLVTKMASDFERVENKDSEVGKIVKEKLALSGDITEAKLTEISSALLA
                     FEKEQNPVDLDAEKEKLVNRLSPRFETLEQAIASKDLEKVREAFKKMNSTWTINESVV
                     RDNSTAHYGRVETAISFLPSSMETKPTDESGT"
     gene            complement(1759..2001)
                     /locus_tag="AC0DU4_000126"
     CDS             complement(1759..2001)
                     /locus_tag="AC0DU4_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019770973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="HIN4236172.1"
                     /translation="MKKDIHPEYRPVVFMDTTTGYQFLSGSTKRSNETVEFEGETYPL
                     IRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLK"
     gene            complement(2097..3032)
                     /locus_tag="AC0DU4_000127"
     CDS             complement(2097..3032)
                     /locus_tag="AC0DU4_000127"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HIN4236173.1"
                     /translation="MEICQQILEKIKEYDTIIIHRHMKPDPDALGSQVGLKALLEHHF
                     PEKTIKAVGFDEPTLTWMAEMDLVEDRAYQGALVIVCDTANTARIDDKRYSQGDFLIK
                     IDHHPNDDVYGDLSWVDTSSSSASEMITLFAQTTQLALADRDAELLFAGIVGDTGRFL
                     YPSTTARTLRLAAYLREHNFDFAALTRKMDTMSYKIAKLQGYIYDHLEVDENGAARVI
                     LSQKILKQYNITDAETAAIVGAPGRIDRVSLWGIFVEQADGHYRVRLRSKVHPINEIA
                     KEHDGGGHPLASGANSYSLEENEIIYQKLKNLLKN"
     gene            3136..3579
                     /locus_tag="AC0DU4_000128"
     CDS             3136..3579
                     /locus_tag="AC0DU4_000128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HIN4236174.1"
                     /translation="MALAKIVFASMTGNTEEIADIVADKLRDLGLDVDVDECTTVDAS
                     DFLEADIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKIYGVVGSGDTFYDEFCKAV
                     DDFDRVFVSTGAEKGSECVKVDLSAEEEDIERLEQFAEELAAKVG"
     gene            3695..3961
                     /locus_tag="AC0DU4_000129"
     CDS             3695..3961
                     /locus_tag="AC0DU4_000129"
                     /EC_number="5.4.99.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate mutase"
                     /protein_id="HIN4236175.1"
                     /translation="MDLDIIRQEIDQIDDQIVKLLEERMHLVEGVVAYKKASGKPILD
                     TKREEVIFEKVRSRVEDKRYQETIVATFSDILKRSRDYQDQNIK"
     gene            3958..4332
                     /gene="crcB"
                     /locus_tag="AC0DU4_000130"
     CDS             3958..4332
                     /gene="crcB"
                     /locus_tag="AC0DU4_000130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HIN4236176.1"
                     /translation="MKKEQFYPLGIFLAAMLGGLVRYLVSTWLPASPDFPWGTLFVNY
                     LGIFCLIFLVKGYLVYKGTSKGLILALGTGFCGGLTTFSSLMLDTVKLLDTGRYLSLV
                     LYLLLSIGGGLLLAYFLGRKKW"
     gene            4326..4655
                     /gene="crcB"
                     /locus_tag="AC0DU4_000131"
     CDS             4326..4655
                     /gene="crcB"
                     /locus_tag="AC0DU4_000131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HIN4236177.1"
                     /translation="MVIVYLAIACGFGALVRYFFSRYNQASKLPLGTLIANLLGCFLI
                     GVFYNHVESKEVYAILATGFCGGLTTFSTLNDELQRLLSDKKVFYSYLTLTYIGGLVA
                     IFLGILL"
     gene            4774..5121
                     /gene="rplS"
                     /locus_tag="AC0DU4_000132"
     CDS             4774..5121
                     /gene="rplS"
                     /locus_tag="AC0DU4_000132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000311 - plastid large ribosomal subunit
                     [Evidence IEA];
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HIN4236178.1"
                     /translation="MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGNRERIQIFE
                     GVVIARKGAGISENYTVRKISNGVGVERIFPIHTPRVEKIEVVRYGKVRRAKLYYLRA
                     LQGKAARIKEIRR"
     gene            5163..5234
                     /locus_tag="AC0DU4_000133"
     tRNA            5163..5234
                     /locus_tag="AC0DU4_000133"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:5196..5198,aa:Arg,seq:cct)
     gene            complement(5289..6095)
                     /gene="yidA"
                     /locus_tag="AC0DU4_000134"
     CDS             complement(5289..6095)
                     /gene="yidA"
                     /locus_tag="AC0DU4_000134"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000023490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HIN4236179.1"
                     /translation="MSIKLIAVDIDGTLVNSQKEITPEVFSAIQDAKEAGVKVVIATG
                     RPIAGVAKLLDDLQLRDQGDYVVTFNGALVQETDTGHEIISESLTYEDYLDMEFLSRK
                     LGVHMHAITKDGIYTANRNIGTYTVHESTLVSMPIFYRTPEEMAGKEIVKCMFIDEPE
                     ILDAAIEKIPAEFYEHYSINKSAPFYLELLKKNVDKGSAITHLAEKLGLTKDETMAIG
                     DEENDRAMLEVVGNPVVMENGNPEIKKIAKYITKTNDESGVAHAIRTLVL"
     gene            complement(6108..7412)
                     /locus_tag="AC0DU4_000135"
     CDS             complement(6108..7412)
                     /locus_tag="AC0DU4_000135"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HIN4236180.1"
                     /translation="MNEKVFRDPVHNYIHVNNQIIYDLINTKEFQRLRRIKQLGTSSY
                     TFHGGEHSRFSHCLGVYEIARRITEIFEEKYPEEWNPAESLLTMTAALLHDLGHGAYS
                     HTFENLFDTDHEAITQEIIQNPETEIHQVLLQVTPDFPEKVASVIDHTYPNKQVVQLI
                     SSQIDADRMDYLLRDSYFTGASYGEFDLTRILRVIRPIENGIAFQRNGMHAIEDYVLS
                     RYQMYMQVYFHPATRAMEVLLQNLLKRAKELYPEDKDFFARTSPHLLPFFEKNVTLTD
                     YLALDDGVMNTYFQLWMTSPDKILADLSHRFVNRKVFKSITFSQEDQDQLTSMRKLVE
                     DIGFDPDYYTAIHKNFDLPYDIYRPESENPRTQIEILQKNGELAELSSLSPIVQSLAG
                     SRHGDNRFYFPKEMLDQNSIFASITQQFLHLIENDHFTPNKN"
     gene            7484..7861
                     /locus_tag="AC0DU4_000136"
     CDS             7484..7861
                     /locus_tag="AC0DU4_000136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HIN4236181.1"
                     /translation="MKIRMRNTIQFDEQLEVIDQLYDVEVHEKGDYSYLLFYNEEKEK
                     VVIKFHGQELVMSRFSNPKTIMRFLKDSDSLAYIPTPMGMQEFIIQTNRYQVDGQKIE
                     LDYQLQNQEGHPFASYQLEITWG"
     gene            7952..8284
                     /locus_tag="AC0DU4_000137"
     CDS             7952..8284
                     /locus_tag="AC0DU4_000137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014637934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HIN4236182.1"
                     /translation="MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEE
                     FGVSRQAVYDNIKRTEKILEDYEMKLHMYSDYIVRSQIFDQILERYPKDDFLQEQIEI
                     LTSIDNRE"
     gene            8296..9867
                     /gene="ffh"
                     /locus_tag="AC0DU4_000138"
     CDS             8296..9867
                     /gene="ffh"
                     /locus_tag="AC0DU4_000138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002902912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0048501 - signal recognition particle,
                     plasma membrane targeting [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005048 - signal sequence binding
                     [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HIN4236183.1"
                     /translation="MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADV
                     ALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVDEELTAVLGSDTAEIIKSPKIPT
                     IIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPV
                     FALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKVLAQPNEI
                     LLVVDAMIGQEAANVAREFNAQLEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGT
                     GEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEMAEKMRENTFDFNDF
                     IDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPD
                     LLNPSRRRRIAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLP
                     KNMPNMGGMDMSALEGMMGQGGMPDLSALGGAGMPDMSQMFGGGLKGKIGEFAMKQSM
                     KRMANKMKKAKKKRK"
     gene            complement(10062..11345)
                     /locus_tag="AC0DU4_000139"
     CDS             complement(10062..11345)
                     /locus_tag="AC0DU4_000139"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007554578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0015851 - nucleobase transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-xanthine permease family protein"
                     /protein_id="HIN4236184.1"
                     /translation="MKQESTVDLLLDVDQRPSAGKGILLSFQHVFAMFGATILVPLIL
                     GMPVSVALFASGVGTLIYMLATGFKVPVYLGSSFAFITAMSLAMKEMGGDVSAAQTGV
                     ILTGLVYVLVATSIRFVGTKWIDKLLPPIIIGPMIIVIGLGLAGSAVTNAGLVADGNW
                     KNALVAVVTFLIAAFINTKGKGFLRIIPFLFAIIGGYLFALTLGLVDFTPVLEANWFE
                     IPGFYLPFSTGGAFKEYNLYFGPEAIAILPIAIVTISEHIGDHTVLGQICGRQFLKEP
                     GLHRTLLGDGIATSVSAFLGGPANTTYGENTGVIGMTRIASVSVIRNAAFIAIALSFL
                     GKFTALISTIPNAVLGGMSILLYGVIASNGLKVLIKERVDFAQMRNLIIASAMLVLGL
                     GGAILKLGPVTLSGTALSAMTGIILNLILPYENKD"
     gene            complement(11599..12312)
                     /gene="rsmG"
                     /locus_tag="AC0DU4_000140"
     CDS             complement(11599..12312)
                     /gene="rsmG"
                     /locus_tag="AC0DU4_000140"
                     /EC_number="2.1.1.170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0031167 - rRNA methylation [Evidence IEA];
                     GO_process: GO:0046118 - 7-methylguanosine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HIN4236185.1"
                     /translation="MKPKTFYNLLAEQNLPLSDQQKEQFERYFELLVEWNEKINLTAI
                     TDKEEVYLKHFYDSIAPILQGLIPNETIKLLDIGAGAGFPSLPMKILYPELDVTIIDS
                     LNKRINFLQLLAQELDLNGVHFYHGRAEDFAQDKNFRAQYDFVTARAVARMQVLSELT
                     IPYLKVGGKLLALKASNAPEELLEAKNALNLLFSKVEDNLSYALPNRDPRYITVVEKK
                     KETPNKYPRKAGMPNKRPL"
     gene            12406..12966
                     /locus_tag="AC0DU4_000141"
     CDS             12406..12966
                     /locus_tag="AC0DU4_000141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LemA family protein"
                     /protein_id="HIN4236186.1"
                     /translation="MTWIILGVIALIVIFVIVSYNGLVKNRMQTKEAWSQIDVQLKRR
                     NDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAATSPAEAMKASDALTRQVSGIFAV
                     AESYPDLKASANFVKLQEELTNTENKISYSRQLYNSVVSNYNVKLETFPSNIIAGMFG
                     FKAADFLQTPEEEKSVPKVDFSGLGD"
     gene            12968..13867
                     /gene="htpX"
                     /locus_tag="AC0DU4_000142"
     CDS             12968..13867
                     /gene="htpX"
                     /locus_tag="AC0DU4_000142"
                     /EC_number="3.4.24.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease HtpX"
                     /protein_id="HIN4236187.1"
                     /translation="MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLV
                     IALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAPDLYHVVEDMALVAQIPMPRVFI
                     IDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV
                     ALASAITMLSGMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLV
                     QLAISRQREFLADASSVELTRNPQGMINALDKLDNSKPMSRHVDDASSALYINDPKKG
                     GGFQKLFYTHPPISERIERLKQM"
     gene            complement(13911..15470)
                     /locus_tag="AC0DU4_000143"
     CDS             complement(13911..15470)
                     /locus_tag="AC0DU4_000143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4236188.1"
                     /translation="MHYEHSRKGNHMIKINHLTITQNKDLRDLVSDLTMTIQDGEKVA
                     IIGEEGNGKSTLLKILMGEALSDFTIKGNIQSDYQSLAYIPQKLPEELKKKTLHDYFF
                     LDSIDLDYSILYRLAEELHFDSNRFASDQEIGNLSGGEALKIQLIHELAKPFEILFLD
                     EPSNDLDLETVDWLKGQIQKTRQTVIFISHDEDFLSETADTIVHLRLVKHRKEAETLV
                     EHLDYDSYSEQRKANFAKQSQQAANNQRAYDKTMEKHRRVKQNVETALRATKDSTAGR
                     LLSKKMKTVLSQEKRYEKAAQSMTQKPLEEEQIQLFFSDIQPLPASKVLVQLEKENLS
                     IDDRVLVQKLQLTVRGQEKIGIIGPNGVGKSTLLAKLKQLLNDKREISLGFMPQDYHK
                     KLQLDLSPIAYISKTGEKEELQKIHSHLASLNFSYPEMQHQIRSLSGGQQGKLLLLDL
                     VLRKPNFLLLDEPTRNFSPTSQPQIRKLFATYPGGLITVSHDRRFLKEVCSIIYRMTE
                     HGLKLVNLEDL"
     gene            complement(15709..16026)
                     /locus_tag="AC0DU4_000144"
     CDS             complement(15709..16026)
                     /locus_tag="AC0DU4_000144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
                     /protein_id="HIN4236189.1"
                     /translation="MEDKKLIQLLSKLNKSYQNCKQGTADDIRLQELLNTTMQELKKT
                     EQLNNSILIDLEKFYQPTSLLIGLGSLKLNDQARTAWRNYDKFHYEHVKHVLSLYGPV
                     FEF"
     gene            16196..16738
                     /locus_tag="AC0DU4_000145"
     CDS             16196..16738
                     /locus_tag="AC0DU4_000145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YceD family protein"
                     /protein_id="HIN4236190.1"
                     /translation="MKLNIQEIRKQSEGLNFEQTLDLVDDLRARNQEILDVKDILAVG
                     KVQYEDRMYFLDYQLSYTIVLASSRSMEPVELVESYPVTEVFMEGATNQLDQEVLDDD
                     LVLPIENGELDLAESVSDNILLNIPIKVLTAEEEAGQGFISGNDWQIMTEEEYQAQKA
                     VKKEENSPFAGLQGLFDGDE"
     gene            16738..17367
                     /gene="nth"
                     /locus_tag="AC0DU4_000146"
     CDS             16738..17367
                     /gene="nth"
                     /locus_tag="AC0DU4_000146"
                     /EC_number="4.2.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000244461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0140078 - class I DNA-(apurinic or
                     apyrimidinic site) endonuclease activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HIN4236191.1"
                     /translation="MVLSKKRARKVLEEIITLFPDAKPSLDFTNHFELLVAVMLSAQT
                     TDAAVNKATPGLFVAFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDF
                     DGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPL
                     EVEKRVMDILPPEQWLAAHQAMIYFGRAICHPKNPECDQYPQLYDFSNL"
     gene            17578..18099
                     /gene="pyrR"
                     /locus_tag="AC0DU4_000147"
     CDS             17578..18099
                     /gene="pyrR"
                     /locus_tag="AC0DU4_000147"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HIN4236192.1"
                     /translation="MKTKEVVDELTVKRAITRITYEIIERNKDLNKIVLAGIKTRGVF
                     IAHRIQERLKQLENLSVPVVELDTKPFRDDVKSGEDTSLVSVDVTDREVILVDDVLYT
                     GRTIRAAIDNIVGHGRPARVSLAVLVDRGHRELPIRPDYVGKNIPTSRSEEIIVEMTE
                     LDDQDRVLITEEA"
     gene            18118..19041
                     /locus_tag="AC0DU4_000148"
     CDS             18118..19041
                     /locus_tag="AC0DU4_000148"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001293822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004070 - aspartate carbamoyltransferase
                     activity [Evidence IEA];
                     GO_function: GO:0016597 - amino acid binding [Evidence
                     IEA];
                     GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase catalytic
                     subunit"
                     /protein_id="HIN4236193.1"
                     /translation="MSENQQALNHVVSMEDLTVDQVMKLIKRGIEFKNGAQLPYEDHP
                     IVSNLFFEDSTRTHKSFEVAEIKLGLERLDFDVKTSSVNKGETLYDTILTLSALGVDV
                     CVIRHPEVDYYRELIASPTITTSIINGGDGSGQHPSQSLLDLMTIYEEFGHFEGLKVA
                     IAGDLDHSRVAKSNMQILKRLGAELFFAGPEEWRSQEFADYGQFVTIDEIIDQVDVMM
                     FLRVQHERHDSGAVFSKEDYHAQHGLTQERYDRLKETAILMHPAPINRDVEIADHLVE
                     APKSRIVQQMTNGVFVRMAILESVLASRNAN"
     gene            19091..20170
                     /locus_tag="AC0DU4_000149"
     CDS             19091..20170
                     /locus_tag="AC0DU4_000149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_process: GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl phosphate synthase small subunit"
                     /protein_id="HIN4236194.1"
                     /translation="MTKRILVLEDGTVFEGKAFGADIDVTGEIVFNTGMTGYQESITD
                     QSYNGQILTFTYPLVGNYGINRDDYESIIPTCKGVVVFEEARRASNWRNQMTLDEFLK
                     AKKIPGISGIDTRALTKIIRKHGTMRATLTHVGDSMDHVTDQLQATVLPTDNIKQVST
                     KTSYPAPGVGLSVVLVDFGLKHSILRELSKRNCNVTVVPYSTTAEEILHLNPDGVMLS
                     NGPGNPEDVPQALDMIRGVQGKIPIFGICMGHQLFAMANGAKTYKMKFGHRGFNHAVR
                     EIATGRVDFTSQNHGYAVSREDLPEHLIITHEEINDKSVEGVRHRYQPAFSVQYHPDA
                     APGPHDASYLFDEFIEMMEVFKQSN"
     gene            20483..23659
                     /gene="carB"
                     /locus_tag="AC0DU4_000150"
     CDS             20483..23659
                     /gene="carB"
                     /locus_tag="AC0DU4_000150"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HIN4236195.1"
                     /translation="MPKRTDIQKIMVIGSGPIIIGQAAEFDYAGTQACLSLKEEGYEV
                     VLVNSNPATIMTDKEIADKVYIEPITLEFVTRILRKERPDALLPTLGGQTGLNMAMEL
                     SKNGILDELGVELLGTKLSAIDQAEDRDLFKQLMEELEQPIPESEIVNTVEEAVAFAA
                     TIGYPVIVRPAFTLGGTGGGMCANEKELREITENGLKLSPVTQCLIERSIAGFKEIEY
                     EVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPAQTMSDYENQMLRDASLSIIRALK
                     IEGGCNVQLALDPNSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEV
                     INPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERRLGTQMKATGEVMAIGRNIEES
                     LLKACRSLEIGVHHNEIPELAAVSDDALIEKVVKAQDDRLFYVSEAIRRGYTPEEIAE
                     LTKIDIFYLDKLFHIFEIEQELGAHPQDLEVLKTAKLNGFSDRKIAELWGTTDDKVRQ
                     LRLENKIVPVYKMVDTCAAEFDSETPYFYSTYGWENESIRSDKESVLVLGSGPIRIGQ
                     GVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDL
                     EQPKGVIVQFGGQTAINLAEPLAKAGVTILGTQVADLDRAEDRDLFEQALKELDIPQP
                     PGQTATNEEEAALAARKIGFPVLVRPSYVLGGRAMEIVENEEDLRSYMRTAVKASPDH
                     PVLVDSYIVGQECEVDAISDGKDVLIPGIMEHIERAGVHSGDSMAVYPPQTLSQKVQE
                     TIADYTKRLAIGLHCLGMMNIQFVIKDEKVYVIEVNPRASRTVPFLSKVTNIPMAQVA
                     TKLILGQSLSELGYQNGLYPESTRVHIKAPVFSFTKLAKVDSLLGPEMKSTGEVMGSD
                     ATLEKALYKAFEASYLHLPTFGNVVFTIADDAKEEALNLARRFQNIGYGILATEGTAA
                     FFASHGLQAQPVGKIGDDDKDIPSFVRKGRIQAIINTVGTKRTADEDGEQIRRSAIEH
                     GVPLFTALDTANAMLKVLESRSFVTEAI"
     gene            complement(23934..24743)
                     /locus_tag="AC0DU4_000151"
     CDS             complement(23934..24743)
                     /locus_tag="AC0DU4_000151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LicD family protein"
                     /protein_id="HIN4236196.1"
                     /translation="MQYLEKKEIKEIQLALLDYIDETCKKHDIPYFLSYGTMLGAIRH
                     KGMIPWDDDIDISLYREDYERLLKIIEEENHPRYKVLSYDTSSWYFHNFASILDTSTV
                     IEDHVKYKRHDTSLFIDVFPIDRFTDLSIVDKSYKYVALRQLAYIKKSRAVHGDSKLK
                     DFLRLCSWYALRFVNPRYFYKKIDQLVKNAVTNTPQYEGGVGIGKEGMKEIFPVDTFK
                     ELILTEFEGRMLPVPKKYDQFLTQMYGDYMTPPSKEMQEWYSHSIKAYRKN"
     gene            complement(24745..25548)
                     /locus_tag="AC0DU4_000152"
     CDS             complement(24745..25548)
                     /locus_tag="AC0DU4_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LicD family protein"
                     /protein_id="HIN4236197.1"
                     /translation="MKQLTVEDAKQIELEILNYIDTLCKKHNINYIINYGTLIGAVRH
                     EGFIPWDDDIDLSMPREDYQRFINIFQKEKSKYKLLSLETDKNYFNNFIKITDSTTKI
                     IDTRNTKTYESGIFIDIFPIDRFDDPKVIDTCYKLESFKLLSFSKHKNIVYKDSLLKD
                     WIRTAFWLLLRPVSPRYFANKIEKEIQKYSRENGQYMAFIPSKFKEKEVFPSGTFDKT
                     IDLPFENLSLPAPEKFDTILTQFYGDYMTLPPEEKRFYSHEFHAYKLED"
     gene            complement(25558..27045)
                     /gene="tacF"
                     /locus_tag="AC0DU4_000153"
     CDS             complement(25558..27045)
                     /gene="tacF"
                     /locus_tag="AC0DU4_000153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV teichoic acid flippase TacF"
                     /protein_id="HIN4236198.1"
                     /translation="MKSIKLNALSYMGIRVLNIIFPILTGTYVARVLDRTDYGYFNSV
                     DTILSFFLPFATYGVYNYGLRAISNVKDNKKDLNRTFSSLFYLCIACTILTTAVYILA
                     YPLFFTDNPIVKKVYLVMGIQLIAQIFSIEWVNEALENYSFLFYKTAFIRILMLVSIF
                     LFVKNEHDIVVYTLVMSLSTLINYLISYFWIKRDIKLVKIHLSDFKPLFLPLTAMLVF
                     ANANMLFTFLDRLFLVKTGIDVNVSYYTIAQRIVTVIAGVVTGAIGVSVPRLSYYLGK
                     GDKEAYVSLVNRGSRIFNFFIIPLSFGLMVLGPNAILLYGSEKYIGGGILTSLFAFRT
                     IILALDTILGSQILFTNGYEKRITVYTVFAGLLNLGLNSLLFFNHIVAPEYYLLTTML
                     SETSLLVFYIIFIHRKQLIHLGHIFSYTVRYSLFSLSFVAIYFLINFMYPVDMVINLP
                     FLINTGLIVLLSAISYISLLVFTKDSIFYEFLNHVLALKNKFKKS"
     gene            27381..28088
                     /locus_tag="AC0DU4_000154"
     CDS             27381..28088
                     /locus_tag="AC0DU4_000154"
                     /EC_number="2.7.7.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0070567 - cytidylyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IspD/TarI family cytidylyltransferase"
                     /protein_id="HIN4236199.1"
                     /translation="MIYAGILAGGTGTRMGISNLPKQFLELGDRPILIHTIEKFVLEP
                     SIEKIVVGVHGDWVSHAEDLVDKYLPLHKERIIITKGGADRNTSIEKIIEAIDAYRPL
                     TSEDIVVTHDSVRPFITLRMIQDNIQLAQNHDAVDTVVEAVDTIVESTNGQFITDIPN
                     RAHLYQGQTPQTFRCKDFMDLYGSLSDEEKEILTDACKIFVIKGKDVALAKGEYSNLK
                     ITTVTDLKIAKSMIEKD"
     gene            28093..29115
                     /locus_tag="AC0DU4_000155"
     CDS             28093..29115
                     /locus_tag="AC0DU4_000155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribitol-5-phosphate dehydrogenase"
                     /protein_id="HIN4236200.1"
                     /translation="MINQIYQLTKPKFINVKYQEEVIDQENHILIRPNYMAVCHADQR
                     YYQGKRDPKILNKKLPMAMIHESCGTVISDPTGTYEVGQKVVMIPNQSPMQSDEEFYE
                     NYMTGTHFLSSGFDGFMREFVSLPKDRVVAYDAIEDTVAAITEFVSVGMHAMNRLLTL
                     AHSKRERIAVIGDGSLAFVVANIINYTLPEAEIVVIGRHWEKLELFSFAKECYITDNI
                     PEDLAFDHAFECCGGDGTGPAINDLIRYIRPQGTILMMGVSEYKVNLNTRDALEKGLI
                     LVGSSRSGRIDFENAIQMMEVKKFANRLKNILYLEEPVREIKDIHRVFATDLNTAFKT
                     VFKWEV"
     gene            29132..30001
                     /gene="licA"
                     /locus_tag="AC0DU4_000156"
     CDS             29132..30001
                     /gene="licA"
                     /locus_tag="AC0DU4_000156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline kinase LicA"
                     /protein_id="HIN4236201.1"
                     /translation="MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIV
                     KFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAGIKVNEYIEFAITLDSTSI
                     KTKFDKIAPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLE
                     KRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTS
                     QEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRA
                     VKGLASYGGSDEK"
     gene            29991..30869
                     /locus_tag="AC0DU4_000157"
     CDS             29991..30869
                     /locus_tag="AC0DU4_000157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HIN4236202.1"
                     /translation="MKSKNGVPFGLLSGIFWGLGLTVSAYIFSIFTDLSPFVVAAAHD
                     FLSIFILLAFLLVKEGKVRLSIFLNIRNVSVIIGALLAGPIGMQANLYAVKYIGSSLA
                     SSVSAIYPAISVLLAFFFLKHKISKNTVFGIVLIIGGIIAQTYKVEQVNSFYIGILCA
                     LVCAIAWGSESVLSSFAMESELSEIEALLIRQVTSFLSYLVIVLFSHQSFTAVANGQL
                     LGLMIVFAAFDMISYLAYYIAINRLQPAKATGLNVSYVVWTVLFAVVFLGAPLDMLTI
                     MTSLVVIAGVYIIIKE"
     gene            30881..31570
                     /locus_tag="AC0DU4_000158"
     CDS             30881..31570
                     /locus_tag="AC0DU4_000158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar phosphate nucleotidyltransferase"
                     /protein_id="HIN4236203.1"
                     /translation="MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEK
                     GINDIIIIVGYLKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANSYVIDAD
                     NYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFW
                     DAPTAEKIVSFIDKAYASGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDY
                     RKLEEIFKNEN"
     gene            31666..32514
                     /gene="dprA"
                     /locus_tag="AC0DU4_000159"
     CDS             31666..32514
                     /gene="dprA"
                     /locus_tag="AC0DU4_000159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009294 - DNA-mediated transformation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-processing protein DprA"
                     /protein_id="HIN4236204.1"
                     /translation="MKITNYEIYKLKKSSLTNQQILKVLEYGENVDQELLLGDIADIS
                     GCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDCYPWDLSEIYDAPVLLFYKGNLD
                     LLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
                     TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRG
                     VIVAEAKMRSGSLITCERAMEEGRDVFAIPDSILDGLSDGCHHLIQEGAKLVTSGQDV
                     LAEFEF"
     gene            33398..34441
                     /locus_tag="AC0DU4_000160"
     CDS             33398..34441
                     /locus_tag="AC0DU4_000160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00341 family protein"
                     /protein_id="HIN4236205.1"
                     /translation="MTNNKLYSLIEFRNKIYEELELSRSDLAILLCAMLIASIGLNMD
                     STPVIIGAMLISPLMTPILGVGLSLAIFDFKLLRKSFKILAIQILASLIASTLYFYLS
                     PISYASSEIVARTSPTIWDVLIAFVGGIAGIIGARKKETNNIVPGVAIATALMPPLCT
                     VGYAIASANLKFIIGSSYLFLINCSFIVIATYIGVRLMMVKKHYFKDNEEDSKMRRIL
                     LLVAVLLMIPSFISATTLVRETLKKESLKKFISEQFQGYNILKKTYSKKTHTLKLTIS
                     GNYLTEEELDMISSKRGDYGLSDVSVQVSQLSDSEQLSKEELVEYFFQYIKDKEAKEK
                     EKANKFDTESEEQ"
     gene            34608..36695
                     /gene="topA"
                     /locus_tag="AC0DU4_000161"
     CDS             34608..36695
                     /gene="topA"
                     /locus_tag="AC0DU4_000161"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003917 - DNA topoisomerase type I (single
                     strand cut, ATP-independent) activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HIN4236206.1"
                     /translation="MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGH
                     IRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAIS
                     WHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYS
                     ISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHAS
                     FYGVDGKKMKLTSNNEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAAN
                     KINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGS
                     KYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQM
                     TAAVFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMAVGDVVKQVNS
                     KPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTEL
                     GEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEE
                     EMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPS
                     CHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQV
                     VCSKGDYEEEKIK"
     gene            36801..37160
                     /locus_tag="AC0DU4_000162"
     CDS             36801..37160
                     /locus_tag="AC0DU4_000162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YbaN family protein"
                     /protein_id="HIN4236207.1"
                     /translation="MRLIYLIIGFLSLALAIVGVVLPLLPTTPFLLLSIACFSRSSKR
                     FEDWLYHTKLYQTYVADFRETKSITRERKKKIIVSIYVLMGISIYFAPLLPVKIGLGA
                     LTIFITYYLFKVIPDKE"
     gene            37253..37885
                     /locus_tag="AC0DU4_000163"
     CDS             37253..37885
                     /locus_tag="AC0DU4_000163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HIN4236208.1"
                     /translation="MIYEFCAENVTLLEKAMQAGARRIELCDNLAVGGTTPSYGVTKA
                     AVELAANYDTTIMTMIRPRGGDFVYNDLEIAIMLEDIRLTAQAGSQGVVFGTLTADKK
                     LDKPNLEKLIAASKGMEIVFHMAFDELSDEDQPEAIDWLSQAGVTRILTRAGVSGDSL
                     EKRFVHYHRILEYAKGKIEILPGGGIDLENRQTFIDQVGVTQLHGTKVVF"
     gene            37929..38585
                     /locus_tag="AC0DU4_000164"
     CDS             37929..38585
                     /locus_tag="AC0DU4_000164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="HIN4236209.1"
                     /translation="MFEIFKSYQFNQEKAHDYGFIENSEVWTYSCQILQGDFVMTVSI
                     TADNVNFQVFDQETGDLYPHVHMESMRGSFVGNVREACLEILYQIRKACFDVQDFICH
                     QTKRIMTQVQEKYGNQLEYLWEKSPDTAVLRHEGNQKWYAVLMKISWNKLEKGREGQV
                     EAVNLKHDQVANLLSQKGIYPAFHMSKRYWISVSLDDTLSDEEVLELIEKSWNLTSKK
                     "
     gene            38649..39698
                     /locus_tag="AC0DU4_000165"
                     /pseudo
     CDS             38649..39698
                     /locus_tag="AC0DU4_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261078.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA];
                     GO_process: GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-isopropylmalate synthase regulatory
                     domain-containing protein"
     gene            39710..40747
                     /gene="leuB"
                     /locus_tag="AC0DU4_000166"
     CDS             39710..40747
                     /gene="leuB"
                     /locus_tag="AC0DU4_000166"
                     /EC_number="1.1.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003862 - 3-isopropylmalate dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
                     /protein_id="HIN4236210.1"
                     /translation="MAKKIVALAGDGIGPEIMEAGLEVLEALAEKTGFDYEIDRRPFG
                     GADIDAAGSPLPDETLKASREADAILLVAIGSPQYDGVAVRPEQGLMALRKELNLYAN
                     IRPVKIFDSLKYLSPLKPERISGVDFVVVRELTGEIYFGDHILEERKARDINDYSYEE
                     VERIIRKAFEIARNRRKIVTSIDKQNVLATSKLWRKVAEEVAQDFPDVTLEHQLVDSA
                     AMLMITNPAKFDVIVTENLFGDILSDESSVLSGTLEVMPSASHSENGPSLYEPIHGSA
                     PDIAGQGIANPISMILLVVMMLRDSFGRYEDTERIKRAVETSLAAGILTRDIGGQAST
                     KEMMEAIIARL"
     gene            40744..41013
                     /locus_tag="AC0DU4_000167"
     CDS             40744..41013
                     /locus_tag="AC0DU4_000167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HIN4236211.1"
                     /translation="MKLDEKITLVLLIWNVIIFLIYGIDKFKARRRAWRIPEKILLIL
                     ALTCGGFGAWLAGITFHHKTRKWYFKTVWFLGMVTTLVALYFIWR"
     gene            41017..41376
                     /gene="leuD"
                     /locus_tag="AC0DU4_000168"
     CDS             41017..41376
                     /gene="leuD"
                     /locus_tag="AC0DU4_000168"
                     /EC_number="4.2.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009316 - 3-isopropylmalate dehydratase
                     complex [Evidence IEA];
                     GO_function: GO:0003861 - 3-isopropylmalate dehydratase
                     activity [Evidence IEA];
                     GO_process: GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="HIN4236212.1"
                     /translation="MVGSSREHAAWALADYGFKVVIAGSFGDIHYNNELNNGMLPIVQ
                     PREVREKLAQLKPTDQVTVDLEQQKIISPVEEFTFEIDSKWKHKLLNSLDDIGITLQY
                     EELIAAYEKQRPAYWQD"
     gene            41595..42161
                     /locus_tag="AC0DU4_000169"
                     /pseudo
     CDS             41595..42161
                     /locus_tag="AC0DU4_000169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931891.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="translation factor (SUA5)"
     gene            42327..44258
                     /locus_tag="AC0DU4_000170"
     CDS             42327..44258
                     /locus_tag="AC0DU4_000170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrB family protein"
                     /protein_id="HIN4236213.1"
                     /translation="MNKRKVSLEDFYKWYSLNKEELLNKATVGEKFNDKLKEEFLQEW
                     PLDRILTMSIDEYVIGKGQQNKSLCYALEKGKYKNLFLGISGGSASKFGIYWNKKTNK
                     YKDQANNEISELDQRFSKLKSDLYEIIKEGIRFNFENPIFDMKRSTNEFIGRSAMVTK
                     LLCIYTEGDPFFGVNINSQKEFWNHFVSQTNQGGPYLQNHKIIELVSKTYPELEPSKL
                     GTMLFEYSKLFMENKEDNSTMDSSNNFSHQLTQSLLKSPNLILRGAPGTGKTYLAKEI
                     AKELTDGNEDQIGFVQFHPSYDYTDFVEGLRPVSNGDGAIEFRLQDGIFKDFCQKAKE
                     TQLIGGQDNFDEAWDSYLEYINVAEEKEYITKTSYLSVNSRQNLSVNYDSGVPGWSLP
                     SKYVYELYKDKNYNKQEYYKSGGKTVLETLRKRFGLKDYVSPTEIDTDKKFVFIIDEI
                     NRGEISKIFGELFFSIDPGYRGEKGSVSTQYANLHETDEKFYIPENVYIIGTMNDIDR
                     SVDTFDFAMRRRFRFVEVTAEGQVGMLDKELNIHAEEAKIRLRNLNAAIENVQELNSH
                     YHIGPSYFLKLKDVDFDYELLWSDYIKPLLEDYLRGSYDEVETLETLKKAFELTNNEQ
                     KDQAVADDNEGDENDDADY"
     gene            44245..45561
                     /locus_tag="AC0DU4_000171"
     CDS             44245..45561
                     /locus_tag="AC0DU4_000171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001223073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrC family protein"
                     /protein_id="HIN4236214.1"
                     /translation="MRITDNQHKIIKEKFVEEYPKLSNLLLDRTLESLSQDERIFIFP
                     NDLTHTPDLDKDQKIFETVNQKIKTGNVIGFLGYGQERLTISSRFSDESNDHFLHYLL
                     NKVLHINLTSLDVALSREERLYQLLMYLFPKYLQAAIRKGLYKEYQRFSHNDSHVKGV
                     IDVRNHLKKNLPFTGNIAYATREFTYDNPLMQLVRHTIEYIKNQKSIGQGVLDNLSTS
                     RENVSEIVRVTPSYKLADRAKIIRGNQSKPIRHAYFHEYRNLQELCLMILNQEKHGLG
                     YQDQKIYGILFDVAWLWEEYVYTLLPKGFVHPRNKDKTDGISVFSVGKRKVYPDFYDR
                     ERKIVLDAKYKKLELTEKGINREDLFQLISYSYILKAEKAGLIFPSMEQSVNSEIGKV
                     AGYGAQLKKWSIRIPQNASFYSTFCKMMENSEENFKAIIDEEVGRK"
     gene            45736..46722
                     /locus_tag="AC0DU4_000172"
     CDS             45736..46722
                     /locus_tag="AC0DU4_000172"
                     /EC_number="1.7.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902560 - GMP reductase complex [Evidence
                     IEA];
                     GO_function: GO:0003920 - GMP reductase activity [Evidence
                     IEA];
                     GO_process: GO:0006163 - purine nucleotide metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GMP reductase"
                     /protein_id="HIN4236215.1"
                     /translation="MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVV
                     PANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPFIKRMHNQGLIASISVGVKDYEY
                     DFVSQLKADTPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
                     AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIA
                     KSIRFGASMIMIGSLFAGHIESPGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRIL
                     LPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNSIWNGDASH"
     gene            46786..46857
                     /locus_tag="AC0DU4_000173"
     tRNA            46786..46857
                     /locus_tag="AC0DU4_000173"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:46819..46821,aa:Arg,seq:ccg)
     gene            47040..47738
                     /gene="rnc"
                     /locus_tag="AC0DU4_000174"
     CDS             47040..47738
                     /gene="rnc"
                     /locus_tag="AC0DU4_000174"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004525 - ribonuclease III activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HIN4236216.1"
                     /translation="MKELQTVLKNHFAIEFADKNLLETAFTHTSYANEHRLLKISHNE
                     RLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKL
                     GKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
                     YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQE
                     AAKNAVEKGLDSCI"
     gene            47729..51268
                     /gene="smc"
                     /locus_tag="AC0DU4_000175"
     CDS             47729..51268
                     /gene="smc"
                     /locus_tag="AC0DU4_000175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007059 - chromosome segregation [Evidence
                     IEA];
                     GO_process: GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HIN4236217.1"
                     /translation="MYLKEIEIQGFKSFADKTKVVFDQGVTAVVGPNGSGKSNITESL
                     RWALGESSVKSLRGGKMPDVIFAGTESRKPLNYASVVVTLDNHDGFIKDAGQEIRVER
                     HIYRSGDSEYKIDGKKVRLRDIHDLFLDTGLGRDSFSIISQGKVEEIFNSKPEERRAI
                     FEEAAGVLKYKTRRKETESKLQQTQDNLDRLEDIIYELDNQIKPLEKQAENACKFLDL
                     EGQRKAIYLDVLVAQIKENKAELESTEEELAQVQELLMSYYQKREKLEEENQTLKKQR
                     QDLQAEMAKDQGSLMDLTSLISDLERKLALSKLESEQVALNQQEAQARLAALEDKRNS
                     LSKEKSDKESSLALLEGNLVQNNQKLNRLEAELLAFSDDPDQMIELLRERFVALLQEE
                     ADVSNQLTRIENELENSRQLSQKQADQLEKLKEQLAIAKEKASQQKEELETAKEQVQK
                     LLADYQAIAKEQEEQKTSYQAQQSQLFDRLDNLKNKQARAQSLENILRNHSNFYAGVK
                     SVLQEKDRLGGIIGAVSEHLTFDMHYQTALEIALGASSQHIIVEDENAATKAIDFLKR
                     NRAGRATFLPLTTIKARTISSQNQDAIAVSPGFLGMADELVTFDTRLEAIFKNLLATT
                     AIFDTVEHAREAARQVRYQVRMVTLDGTELRTGGSYAGGANRQNNSIVIKPELEQLQK
                     EIAADEASLGSEEAALKTLQDQMAALTERLEAIKSQGEQARIQEQGLSLAYQQTSQQV
                     EELETLWKLQEEEIDRLSEGDWQADKEKCQESLATIASEKQNLEAEIEEIKSNKNAIQ
                     ERYQNLQEEVAQARLLKTELQGQKRYEVADIERLGKELDNLNIEQEEIQRMLQEKVDN
                     LEKVDTELLSQQAEESKTQKTNLQQGLIRKQFELDDIEGQLDDIASHLDQARQQNEEW
                     IRKQTRAEAKKEKVSERLRHLQNQLTDQYQISYTEALEKAHELENLNLAEQEVQDLEK
                     AIRSLGPVNLEAIDQYEEVHNRLDFLNSQRDDILSAKNLLLETITEMNDEVKERFKST
                     FEAIRESFKVTFKQMFGGGQADLILTEGDLLTAGVEISVQPPGKKIQSLNLMSGGEKA
                     LSALALLFSIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKDSQFIVVTHRKGT
                     MAAADSIYGVTMQESGVSKIVSVKLKDLESIEG"
     gene            51265..52059
                     /locus_tag="AC0DU4_000176"
     CDS             51265..52059
                     /locus_tag="AC0DU4_000176"
                     /EC_number="3.-.-.-"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000153012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HIN4236218.1"
                     /translation="MTIKLVATDMDGTFLDGNGRFDMDRLKSLLASYKEKGIYFAVAS
                     GRGFLSLEKLFADVRDDIIFIAENGSLVEYQGQDLYEATMSRDFYLATFEKLKTSPYV
                     DINKLLLTGKKGSYVLDTVDETYLKVSQHYNENIQKVASLEDITDDIFKFTTNFTEET
                     LEAGEAWVNEHVPGVKAMTTGFESIDIVLDYVDKGVAIVELAKKLGITMDQVMAFGDN
                     LNDLHMMQVVGHPVAPENARPEILELAKTVIGHHKERSVIAYMEGL"
     gene            52059..52877
                     /locus_tag="AC0DU4_000177"
     CDS             52059..52877
                     /locus_tag="AC0DU4_000177"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HIN4236219.1"
                     /translation="MADIKLIALDLDGTLLTTDKRLTDRTKETLKAARDRGIKVVLTT
                     GRPLKAMDFFLHELGTDGHEDEYTITFNGGLVQKNTGEILDKTVFSYDDVARLYEETE
                     KLSLPLDAISEGTVYQIQSDQESLYAKFNPALTFVPVDFEDLSSQMTYNKCVTAFAQE
                     PLDAAIQKISPELFDQYEIFKSREMLLEWSPKNVHKATGLAKLISHLGIDQSQVMACG
                     DEANDLSMIEWAGLGVAMQNAVSEVKAAANVVTPMTNDEEAVAWAIEEYVLKEN"
     gene            52881..54158
                     /gene="ftsY"
                     /locus_tag="AC0DU4_000178"
     CDS             52881..54158
                     /gene="ftsY"
                     /locus_tag="AC0DU4_000178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005047 - signal recognition particle
                     binding [Evidence IEA];
                     GO_process: GO:0006614 - SRP-dependent cotranslational
                     protein targeting to membrane [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HIN4236220.1"
                     /translation="MGLFDRLFGKKEEPKIEEVVKEALENLDLSEDVDPTFTEVEEVS
                     QEEAEVEIVEQAVFQEEEIQDTVEESLDLEPVVEVSQKEVEEFPHSEEGNTEFLETIE
                     ENNSEVLEAERPQAEETVQEKYDRSLKKTRTGFGARLNAFFANFRSVDEEFFEELEEL
                     LIMSDVGVQVASNLTEELRYEAKLENAKKPDALRRVIIEKLVELYEKDGSYDESIHFQ
                     DNLTVMLFVGVNGVGKTTSIGKLAHRYKRAGKKVMLVAADTFRAGAVAQLAEWGRRVD
                     VPVVTGPEKADPASVVFDGMERAVAEGIDILMIDTAGRLQNKDNLMAELEKIGRIIKR
                     VVPEAPHETFLALDASTGQNALVQAKEFSKITPLTGIVLTKIDGTARGGVVLAIREEL
                     NIPVKLIGFGEKIDDIGEFNSENFMKGLLEGLI"
     gene            complement(54202..55689)
                     /gene="zwf"
                     /locus_tag="AC0DU4_000179"
     CDS             complement(54202..55689)
                     /gene="zwf"
                     /locus_tag="AC0DU4_000179"
                     /EC_number="1.1.1.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004345 - glucose-6-phosphate
                     dehydrogenase activity [Evidence IEA];
                     GO_function: GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_process: GO:0006006 - glucose metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="HIN4236221.1"
                     /translation="MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTA
                     RRPWSKEYFESVVVESILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELN
                     EKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATANKLN
                     DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLG
                     VEERGGYYDQSGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTD
                     EELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGAFFVDSDRFRGVPFF
                     FRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFN
                     LAPNSLDYRTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVGASWKLIDRIEELWA
                     ENGAPLHDYKAGSMGPQASFDLLEKFDAKWTWQPDIAYRQDGRFE"
     gene            complement(55838..56578)
                     /locus_tag="AC0DU4_000180"
     CDS             complement(55838..56578)
                     /locus_tag="AC0DU4_000180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015424 - ABC-type amino acid transporter
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HIN4236222.1"
                     /translation="MAKLKIDVNDLHKHYGKNEVLKGITTKFYEGDVVCIIGPSGSGK
                     STFLRSLNLLEEVTSGHITVNGYDLTEKTTNVDHVRENIGMVFQHFNLFPHMSVLDNI
                     TFAPIEHKLMTKEEAEELGMELLEKVGLADKANANPDSLSGGQKQRVAIARGLAMNPD
                     IMLFDEPTSALDPEMVGDVLNVMKELAEQGMTMIIVTHEMGFARQVANRVIFTADGEF
                     LEDGTPDQIFDNPQHPRLKEFLDKVLNV"
     gene            complement(56578..58743)
                     /locus_tag="AC0DU4_000181"
     CDS             complement(56578..58743)
                     /locus_tag="AC0DU4_000181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HIN4236223.1"
                     /translation="MKKKFLAFLLILFPIFSLGIAKAETIKIVSDTAYAPFEFKDSDQ
                     TYKGIDVDIINKVAEIKGWNIQMSYPGFDAAVNAVQAGQADAIMAGMTKTKEREKVFT
                     MSDTYYDTKVVIATTKSHKISKYDQLTGKTVGVKNGTAAQRFLETIKDKYGFTIKTFD
                     TGDLMNNSLSAGAIDAMMDDKPVIEYAINQGQDLHIEMDGEAVGSFAFGVKKGSKYEH
                     LVTEFNQALAEMKKDGSLDKIIKKWTASSSSAVPTTTTLAGLKAIPVKAKYIIASDSS
                     FAPFVFQNSSNQYTGIDMELIKAIAKDQGFEIEITNPGFDAAISAVQAGQADGIIAGM
                     SVTDARKATFDFSESYYTANTILGVKESSNIASYEDLKGKTVGVKNGTASQTFLTENQ
                     SKYGYKIKTFADGSSMYDSLNTGAIDAVMDDEPVLKYSISQGQKLKTPISGTPIGETA
                     FAVKKGANPELIEMFNNGLANLKANGEFQKILDKYLASESSTASTSTVDETTLWGLLQ
                     NNYKQLLSGLGITLALALISFAIAIVIGIIFGMFSVSPYKSLRVISEIFVDVIRGIPL
                     MILAAFIFWGIPNFIESITGQQSPINDFVAGTIALSLNAAAYIAEIVRGGIQAVPVGQ
                     MEASRSLGISYGKTMRKIILPQATKLMLPNFVNQFVIALKDTTIVSAIGLVELFQTGK
                     IIIARNYQSFKMYAILAIFYLVIITLLTRLAKRLEKRIR"
     gene            58916..59869
                     /locus_tag="AC0DU4_000182"
     CDS             58916..59869
                     /locus_tag="AC0DU4_000182"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000792120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
                     /protein_id="HIN4236224.1"
                     /translation="MKNKRIFKDFQASKMNLNIYTSPLLAFVFVFIGEFVAYTLYGIS
                     LLALIGLARNFGEAGQNLASYLQTLHQSLTDKTSDFRLILGLLAFGFILNTVFRWTRK
                     VEKRPIRTLGFYRENFLSNLLKGFSLGLALFLLTLLGLVVLGQYRLESIHLNPYSLAF
                     VVFTIPFWILQGTAEEVVARAWLLPQLASRTNLKLAILISSLFFTLLHMGNSGLTPLS
                     LVNLFLFGVAMALYLLKTDTVWGVAGIHGAWNFAQGNLFGILVSGQPSGTSLMTFLPQ
                     GNQDWLSGGSFGIEGSIMTSLVLLLLIVYLANKLKKENERM"
     gene            59946..61934
                     /gene="uvrB"
                     /locus_tag="AC0DU4_000183"
     CDS             59946..61934
                     /gene="uvrB"
                     /locus_tag="AC0DU4_000183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009380 - excinuclease repair complex
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrB"
                     /protein_id="HIN4236225.1"
                     /translation="MINHITDNQFKLVSKYQPSGDQPQAIEQLVDNIEGGEKAQILMG
                     ATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPENAVEYFVSYYDYYQ
                     PEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYA
                     DSVVSLRPGLEISRDKLLNDLVDIQFERNDIDFQRGRFRVRGDVVEIFPASRDEHAFR
                     VEFFGDEIDRIREVEALTGQVLGEVDHLAIFPATHFVTNDDHMEVAIAKIQAELEEQL
                     AVFEKEGKLLEAQRLKQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPYTLLDFF
                     PDDFLIMIDESHMTIGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVH
                     QIVYVSATPGDYENEQTETVIEQIIRPTGLLDPEVEVRPTMGQIDDLLGEINARVEKN
                     ERTFITTLTKKMAEDLTDYFKEMGIKVKYMHSDIKTLERTEIIRDLRLGVFDVLVGIN
                     LLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVIMYADTVTQSMQ
                     RAIDETARRRKIQMAYNEEHGIVPQTIKKEIRDLIAVTKAVAKEEDKEVDINSLNKQE
                     RKELVKKLEKQMQEAVEVLDFELAAQIRDMMLEVKALD"
     gene            61944..62507
                     /locus_tag="AC0DU4_000184"
     CDS             61944..62507
                     /locus_tag="AC0DU4_000184"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236226.1"
                     /translation="MIYLRKLKREDLMSLWEMAYSQLNPVWKQYDAPYYDDYQYFSNF
                     KEFELQKSESILSNSNRLGIFVDDKLVGTVSRYWVCKQTRWMELGIGIYDKKFWNTGI
                     GKVAMLQWIDRTFQDYLELEHLGLTTWSGNLGMMKLAEKLRMKKEAHIPKVRYYQGKY
                     FDSIKYGILREDWEKMNDGYYQINGNS"
     gene            62473..62982
                     /locus_tag="AC0DU4_000185"
     CDS             62473..62982
                     /locus_tag="AC0DU4_000185"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000216007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236227.1"
                     /translation="MTVIIKSMETPEEIEGKSLVHWQTWREAYDDLLPAEFQETMTLE
                     RCRFFSQKYPENTLIAIGDLKVVGFISYGNFRDETIQAGEIIALYVLKDYYGKGIAQK
                     LMKAALTALNHFSEIFLWVLKDNKRAIAFYQKMGFTFDGQEKILELGKPIKEKRMVFY
                     SKIILKSRS"
     gene            63035..63502
                     /locus_tag="AC0DU4_000186"
     CDS             63035..63502
                     /locus_tag="AC0DU4_000186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HIN4236228.1"
                     /translation="MSRSQLTILTNICLIEDLETQCVVMQYRAPETNRWSGYAFPGGH
                     VENGEAFAESVIREIYEETGLTIQNPQLVGVKNWPLDTGGRYIVFCYKATEFTGTLQS
                     SDEGEVSWVQKDQIPNLNLAYDMLPLMEMMEAPDKSEFFYPRRTEDDWEKKIF"
     gene            complement(63499..64014)
                     /locus_tag="AC0DU4_000187"
     CDS             complement(63499..64014)
                     /locus_tag="AC0DU4_000187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HIN4236229.1"
                     /translation="MTKDRKQALLQLLKEAPKALNGQSLAEHFHVTRQVIVQDIAILR
                     ADGAPILSTNRGYIYKQIDTNPYVHKLFKVKHQVEEIGQELLAIVDNGGHVQNTLIDH
                     PVYGEIETLLKLSCRRDVQHFLEQVEHSDFRPLSELTDGIHYHLVEAETQQDLHYIEE
                     ALDQLGYLVKD"
     gene            complement(64026..64553)
                     /locus_tag="AC0DU4_000188"
     CDS             complement(64026..64553)
                     /locus_tag="AC0DU4_000188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HIN4236230.1"
                     /translation="MNTRKKTQFMTMTALLTAIAILIPIVMPFKIVIPPASYTLGSHI
                     AIFIAMFLSPLMAVFVILASSFGFLMAGYPMVIVFRAFSHISFGALGALYLQKFPDTL
                     DKPKSSWVFNFVLAVVHALAEVLACVLFYATSGTNVENMFYVLFVLVGFGTIIHSMVD
                     YTLALAVYKVLRKRR"
     gene            complement(64835..65398)
                     /locus_tag="AC0DU4_000189"
     CDS             complement(64835..65398)
                     /locus_tag="AC0DU4_000189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HIN4236231.1"
                     /translation="MKKRSNIAPIAIFFATMLVIHFLSSLIFNLFPFPIKPTIVHIPV
                     IIASIIYGPRVGVTLGFLMGLLSLTVNTITILPTSYLFSPFVPNGNIYSAIIAIVPRI
                     LIGLTPYLVYKLMKNKTGLILAGALGSLTNTIFVLGGIFFLFGNVYNGNIQLLLATVI
                     STNSIAELVISAILTLAIVPRLQTLKK"
     gene            complement(65382..65933)
                     /gene="coaC"
                     /locus_tag="AC0DU4_000190"
     CDS             complement(65382..65933)
                     /gene="coaC"
                     /locus_tag="AC0DU4_000190"
                     /EC_number="4.1.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenoylcysteine decarboxylase"
                     /protein_id="HIN4236232.1"
                     /translation="MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQ
                     PLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFADNM
                     VTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHG
                     RGALADLTIILERIKETLDEKTL"
     gene            complement(65945..66634)
                     /gene="coaB"
                     /locus_tag="AC0DU4_000191"
     CDS             complement(65945..66634)
                     /gene="coaB"
                     /locus_tag="AC0DU4_000191"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenate--cysteine ligase"
                     /protein_id="HIN4236233.1"
                     /translation="MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLFAGHEVC
                     LITTKRALKPEPHPNLSIREITNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMTGL
                     EEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLL
                     VDVTEDHLVDIARKSLIKNQADLIIANDLTQISAGQHRAIFVEKNQLQTVQTKEEIAE
                     LLLEKIQAYHS"
     gene            66864..68534
                     /locus_tag="AC0DU4_000192"
     CDS             66864..68534
                     /locus_tag="AC0DU4_000192"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004329 - formate-tetrahydrofolate ligase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HIN4236234.1"
                     /translation="MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDK
                     IRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVM
                     GIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELEIDQRR
                     ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRR
                     LANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIA
                     HGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRAL
                     KMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAAL
                     KELCASIDVPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEK
                     IVTEIYRGSKVNFEKKAQTQIAQIVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEI
                     TIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF"
     gene            68862..70037
                     /gene="mutY"
                     /locus_tag="AC0DU4_000193"
     CDS             68862..70037
                     /gene="mutY"
                     /locus_tag="AC0DU4_000193"
                     /EC_number="3.2.2.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0019104 - DNA N-glycosylase activity
                     [Evidence IEA];
                     GO_process: GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="A/G-specific adenine glycosylase"
                     /protein_id="HIN4236235.1"
                     /translation="MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPY
                     HIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLATAPEESLLKAWEGLGYYSRVRNM
                     QAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLAR
                     LFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVK
                     DFSAAYQNGTMDRYPIKSPKKKPVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFP
                     FIEVDNFSQEEQFDLFHQVAEESVNFGPSPEESFQQDYDLDVDWLDVCFDTVQHVFSH
                     RKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD"
     gene            70092..70796
                     /gene="yycF"
                     /locus_tag="AC0DU4_000194"
     CDS             70092..70796
                     /gene="yycF"
                     /locus_tag="AC0DU4_000194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000722069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator YycF"
                     /protein_id="HIN4236236.1"
                     /translation="MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAE
                     QPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDSEFDKVIGLELGADDYVTKP
                     FSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
                     HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPE
                     YILTRRGVGYYMRNNA"
     gene            70789..72138
                     /gene="vicK"
                     /locus_tag="AC0DU4_000195"
     CDS             70789..72138
                     /gene="vicK"
                     /locus_tag="AC0DU4_000195"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall metabolism sensor histidine kinase
                     VicK"
                     /protein_id="HIN4236237.1"
                     /translation="MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQI
                     NQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFY
                     MTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
                     LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSH
                     ELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATS
                     HLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDN
                     ILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSR
                     AQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED"
     gene            72140..72949
                     /locus_tag="AC0DU4_000196"
     CDS             72140..72949
                     /locus_tag="AC0DU4_000196"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HIN4236238.1"
                     /translation="MSEIGFKYSILASGSSGNSFYLETSKKKLLVDAGLSGKKITSLL
                     AEINRKPEDLDAILITHEHSDHIHGVGVLARKYGMDLYANEKTWQAMENSKYLGKVDS
                     SQKHIFEMGKTKTFGDIDIESFGVSHDAVAPQFYRFMKDDKSFVLLTDTGYVSDRMAG
                     IVENADGYLIEANHDVEILRSGSYAWRLKQRILSDLGHLSNEDGAEAMIRTLGNRTKK
                     IYLGHLSKENNIKELAHMTMVNQLAQADLGVGVDFKVYDTSPDTATPLTEI"
     gene            73040..73282
                     /gene="relB"
                     /locus_tag="AC0DU4_000197"
     CDS             73040..73282
                     /gene="relB"
                     /locus_tag="AC0DU4_000197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001853822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB family
                     antitoxin"
                     /protein_id="HIN4236239.1"
                     /translation="MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYD
                     ARVADLAYQEYLEDLEKGVELITWEEMMHDLGLKDE"
     gene            73284..73538
                     /locus_tag="AC0DU4_000198"
     CDS             73284..73538
                     /locus_tag="AC0DU4_000198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA];
                     GO_function: GO:0004521 - RNA endonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0017148 - negative regulation of
                     translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE family
                     toxin"
                     /protein_id="HIN4236240.1"
                     /translation="MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKAL
                     VGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHRRDIY"
     gene            73585..74328
                     /locus_tag="AC0DU4_000199"
                     /pseudo
     CDS             73585..74328
                     /locus_tag="AC0DU4_000199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731134.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005216 - monoatomic ion channel activity
                     [Evidence IEA];
                     GO_function: GO:0005267 - potassium channel activity
                     [Evidence IEA];
                     GO_process: GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA];
                     GO_process: GO:0071805 - potassium ion transmembrane
                     transport [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="potassium channel family protein"
     gene            complement(74629..75615)
                     /locus_tag="AC0DU4_000200"
     CDS             complement(74629..75615)
                     /locus_tag="AC0DU4_000200"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019768616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004459 - L-lactate dehydrogenase activity
                     [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HIN4236241.1"
                     /translation="MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLH
                     EKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNL
                     AINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQ
                     ALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELF
                     EGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVENVFIG
                     QPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQEASKN"
     gene            75809..78277
                     /gene="gyrA"
                     /locus_tag="AC0DU4_000201"
     CDS             75809..78277
                     /gene="gyrA"
                     /locus_tag="AC0DU4_000201"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001152996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003916 - DNA topoisomerase activity
                     [Evidence IEA];
                     GO_function: GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006259 - DNA metabolic process [Evidence
                     IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HIN4236242.1"
                     /translation="MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHR
                     RILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVD
                     GHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
                     FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTG
                     ALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVR
                     LVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAI
                     QNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIR
                     IIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIAD
                     LADILAKPERVSQIIKDELDEVKRKFSDKRRTELMVGQILSLEDEDLIEESDVLITLS
                     NRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRL
                     KGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTS
                     VKEFANIRQNGLKALNLKDEDELINVLLTEGDMDIIIGTKFGYAVRFNQSAVRGMSRI
                     ATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAK
                     ITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQI
                     VTFTTVAVAEKEEVGTENETEGEA"
     gene            78277..79020
                     /gene="srtA"
                     /locus_tag="AC0DU4_000202"
     CDS             78277..79020
                     /gene="srtA"
                     /locus_tag="AC0DU4_000202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase SrtA"
                     /protein_id="HIN4236243.1"
                     /translation="MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVW
                     NTNKYQVSQVSKEKLEENQDTEGNFDFDSVKAISSEAVLTSQWDAQKLPVIGGIAIPE
                     LEMNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLASHHIFGVDNANKMLFSPLDNA
                     KNGMKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDLAATERIIV
                     KGDLKETKDYSQTSDEILTAFNQPYKQFY"
     gene            79264..80061
                     /locus_tag="AC0DU4_000203"
     CDS             79264..80061
                     /locus_tag="AC0DU4_000203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HIN4236244.1"
                     /translation="MVSSEFISKIEFACNKKESLYSQSKFKYAIRSMFAGAFLTFSTA
                     AGAVGADLINKIAPGSGRFLFPFVFAWGLAYIVFLNAELVTSNMMFLTAGSFLKKISW
                     RKTAEILLYCTLFNLIGALIAGWGFAHSAAYANLIHDSFISGVVEMKLGRSNELVLLE
                     AILANIFVNIAILSFILVKDGGAKLWLVLSAIYMFVFLTNEHIAANFASFAIVKFSVA
                     ADSIANFGVGNMLRHWGVTFIGNFIGGGLLMGLPYAFLNKNEDTYVD"
     gene            80209..81468
                     /locus_tag="AC0DU4_000204"
                     /pseudo
     CDS             80209..81468
                     /locus_tag="AC0DU4_000204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365067.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0019346 - transsulfuration [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase family
                     protein"
     gene            81564..82838
                     /locus_tag="AC0DU4_000205"
     CDS             81564..82838
                     /locus_tag="AC0DU4_000205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2130 domain-containing protein"
                     /protein_id="HIN4236245.1"
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMKQEL
                     ALAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHEALLAKDKEV
                     QLLENQLATLRLEHENQLQKTLSDLEKERDQVKNQLLLQEKENELSLASVKQNYEAQL
                     KAASEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGS
                     KGDFIFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLV
                     TMLEADNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVRE
                     QNIDITHFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQL
                     RLANNKLEDVSVKKLTRKNPTMKAKFEALKGE"
     gene            82848..83726
                     /gene="truB"
                     /locus_tag="AC0DU4_000206"
     CDS             82848..83726
                     /gene="truB"
                     /locus_tag="AC0DU4_000206"
                     /EC_number="5.4.99.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HIN4236246.1"
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGV
                     LPIAVGKATRMVEFMQDEGKIYEGEITLGYSTTTEDASGEVIAETPVLSPLDEKLVDE
                     AIASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVTIYQFERTSPISYDG
                     QLARFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALALEEIAE
                     KVEAGQLDFLHPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDKELAAFEDDKLLA
                     ILEKRGNLYKPRKVFS"
     gene            83967..84269
                     /locus_tag="AC0DU4_000207"
     CDS             83967..84269
                     /locus_tag="AC0DU4_000207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HIN4236247.1"
                     /translation="MMRNEFRERVEQLLQQKEINENSELSHLFRLAIQNLDRNEKHQS
                     VMADLSQGLSLYLMTHHYQAPKSVIDFGLWIAKAPSQERGRLAFLQMLAQTLQGFR"
     gene            84377..85015
                     /gene="udk"
                     /locus_tag="AC0DU4_000208"
     CDS             84377..85015
                     /gene="udk"
                     /locus_tag="AC0DU4_000208"
                     /EC_number="2.7.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="uridine kinase"
                     /protein_id="HIN4236248.1"
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYK
                     DQSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQ
                     EPQDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQ
                     YLGVVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     gene            85143..86483
                     /gene="xseA"
                     /locus_tag="AC0DU4_000209"
     CDS             85143..86483
                     /gene="xseA"
                     /locus_tag="AC0DU4_000209"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA];
                     GO_function: GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA];
                     GO_process: GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HIN4236249.1"
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQY
                     FSLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKAEPDG
                     VGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRF
                     PGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVV
                     RAIFESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLTHLQNQEK
                     RMATAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDN
                     KQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLM
                     LDTSRIVARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     gene            86461..86673
                     /locus_tag="AC0DU4_000210"
     CDS             86461..86673
                     /locus_tag="AC0DU4_000210"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HIN4236250.1"
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKE
                     LQATLDKAEKTLVKVMQEDGTESDFE"
     gene            86670..87545
                     /locus_tag="AC0DU4_000211"
     CDS             86670..87545
                     /locus_tag="AC0DU4_000211"
                     /EC_number="2.5.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004659 - prenyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HIN4236251.1"
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRP
                     FLLLEVLEALQVAIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFG
                     EAMAILAGDALFLDPYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
                     HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVL
                     DVTASFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQVPFE
                     TESIVSVVESLRING"
     gene            87538..88353
                     /locus_tag="AC0DU4_000212"
     CDS             87538..88353
                     /locus_tag="AC0DU4_000212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="HIN4236252.1"
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPG
                     EKIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQ
                     NSAKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISL
                     SLILPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKIHQNVLESVTAMAVEA
                     GFSVLGLDFSPIQGGHGNIEFLAYLKKEKSASNQILAEIKEAVERAHSQFKNE"
     gene            88346..88777
                     /locus_tag="AC0DU4_000213"
     CDS             88346..88777
                     /locus_tag="AC0DU4_000213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HIN4236253.1"
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRD
                     IKELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVK
                     AQLIDTFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            88784..90451
                     /gene="recN"
                     /locus_tag="AC0DU4_000214"
     CDS             88784..90451
                     /gene="recN"
                     /locus_tag="AC0DU4_000214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HIN4236254.1"
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNM
                     MLGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGR
                     SISRVNGQMVNLSVLRAIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKET
                     YQTSFDAYRKMRKQVLKVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLALNQERDK
                     LLNHKNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSETYY
                     VLEDISKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEY
                     NLLTGNNLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKA
                     QFQVRFSKGKFSREGNEMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKE
                     GKTSIVFDEVDTGVSGRVAQAIAQKIHKIGQYGQVLAISHLPQVIAIADYQFFIEKIS
                     NDHSTVSTVRLLTVEERVEEVAKMLAGDDMTEAALTQARELLRNREK"
     gene            90453..91181
                     /locus_tag="AC0DU4_000215"
     CDS             90453..91181
                     /locus_tag="AC0DU4_000215"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0016311 - dephosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HIN4236255.1"
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGQTQLLFLGDLIDRGEDSH
                     RVLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLD
                     APVDGVEDAKRVAAEAADLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKV
                     WLRKPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLH
                     GIVFTDQGMTEHHFIENDGFVAED"
     gene            91260..93083
                     /gene="lepA"
                     /locus_tag="AC0DU4_000216"
     CDS             91260..93083
                     /gene="lepA"
                     /locus_tag="AC0DU4_000216"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation elongation factor 4"
                     /protein_id="HIN4236256.1"
                     /translation="MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLA
                     ACEGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVI
                     GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQ
                     VRVMDGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQD
                     TRVGDTVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQ
                     FEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMD
                     VSNPSEFPDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVN
                     VIYQIPLAEIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFI
                     VHKDFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGG
                     DVSRKRKLLEKQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
     gene            complement(93164..93361)
                     /locus_tag="AC0DU4_000217"
     CDS             complement(93164..93361)
                     /locus_tag="AC0DU4_000217"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236257.1"
                     /translation="MKIKEQTRKLAAGYSKHSFEVVDKTDEVSSKHGFEVVDETDEVS
                     NHTYGKATMTWFEEIFEEYKN"
     gene            93540..94016
                     /locus_tag="AC0DU4_000218"
     CDS             93540..94016
                     /locus_tag="AC0DU4_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HIN4236258.1"
                     /translation="MVLDYFFDKNLVLCLEADNQEQLFDQVASLLEEREIVTPTYREA
                     LITREKSFPTGLDMEFLGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIAPDK
                     EVEVSLLFFIINNSSSSQTNILAQLMNFFTGNGHLEDLSKISEPEKLYAYIDEAIA"
     gene            94054..94356
                     /locus_tag="AC0DU4_000219"
     CDS             94054..94356
                     /locus_tag="AC0DU4_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HIN4236259.1"
                     /translation="MIKILAACGAGVNSSHQIKSTLEEELSNRGYDVHCDAVMVKDVN
                     EDLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFCIPAMSAPVFDNIRLPAKQNTV"
     gene            94364..>94519
                     /locus_tag="AC0DU4_000220"
     CDS             94364..>94519
                     /locus_tag="AC0DU4_000220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
                     /protein_id="HIN4236260.1"
                     /translation="MNDEASKQLTDARFKRLVGVQRTTFEEMLAVLKTAYQLKHAKGG
                     RKPKLSLE"
BASE COUNT        28694 a        16989 c        21039 g        27797 t
ORIGIN      
        1 ccacgtccag aacatcctag gaaagcagac gctcaaacca ttgtcgcgtc taaaaataaa
       61 atctcaattc aagaagaaaa gaaagcgctt taaaaccagt agaccttttc ataaggttcg
      121 cttgatgtac caaatagtac gcccatgcaa aagaatatct attttgttgt cttggacctg
      181 catacgacgg atagagataa aattatccag ctattcaagg attggacgga ttatagtgcc
      241 aagttggtcg agggggaatt ggttaaaaaa gatggacaga atgctctctt tcctccgagc
      301 gatactggtg agacagttgg gctcaatcct catcgtttga cgctgacttt tggtgtatct
      361 gcaagtttct tgaaaaggat gaacttggaa aacaagcgcc ctcgactgtt cagggattta
      421 cctctatttc ctaaggagca attacgtgaa aaatatactg gtggagatat tgtgattcat
      481 gcttgtgcag atgatgagca aattgccttt cacgctattc gcaatctcat ccgtaagggg
      541 agaaatgcgg tgccccttcg ttggagtcag tctggatttg cagctatcgg ggatcgaatg
      601 gagactccgt ggaacctctt tggttttaag gatggaacag caaatccaac caaggagcaa
      661 gactttgacc gcgttatctg ggctgatagt aaggactgga tggaaaatgg ttcttatatg
      721 gcagttcgtc ggattcagat gtttttagag acctgggacc gcactagtct cgaagaacga
      781 gaaaatacct ttggtcgtta caaggaaagc ggtgccccct ttggtaagaa aaatgagttt
      841 gatgaagtgg atttgagtct cttacctgat gattcgcatg tttgtttggc caaagaagtg
      901 gataagccac ttttacgtcg ttcttattct tactcagatg gcattgatga aaagactggt
      961 cagtttgata cgggattgct cttcatttct ttccagaagg atcctgataa ctttgttaag
     1021 gttcaaacta acctaggtgc tactgataag atgaatgaat acatcactca cataggtagt
     1081 ggacttttta cttgctttgg tggtgtggag aaaggaggct acattggtca gaaattattg
     1141 gaaggctaaa agctggttac tagttttagc tttgtcattt ttaattcttt ccccagcagg
     1201 tgcccaagaa agcttgagtt ttttctttgt gaaaatcaca gatgcatcca aaacggttaa
     1261 aaatggtggt cagactgaga cccagaaact cgttacgaag atggcatcag acttcgaaag
     1321 agtagaaaat aaggattctg aggttggtaa gattgttaag gaaaagttag ctctatctgg
     1381 agatattact gaagccaaac tcaccgaaat ttcctcagct ctattagctt ttgaaaaaga
     1441 acaaaatcct gttgacctag atgcggaaaa ggaaaaattg gtaaaccgtc taagtcctcg
     1501 ttttgaaacc ttagagcagg ccattgcctc caaagatttg gaaaaagtcc gagaagcttt
     1561 taagaaaatg aattccactt ggaccatcaa tgaaagtgtg gttcgtgaca atagtacagc
     1621 tcattatgga cgtgttgaaa cagctatttc cttcctgcct agtagcatgg aaaccaaacc
     1681 tacagatgag tctggaacat gaaaacagca gttgatttca agaaacaaaa aagaacagcc
     1741 gaaactgttc tcttatcatt atttgagacc gtattttttg ttgaaacgat ccacgcgtcc
     1801 atctgcttga gtgaactttt gacgtccagt gtagaatggg tgtgagtctg atgaaatttc
     1861 cacacggatc aatgggtaag tttcgccttc gaactcaact gtttcgttag agcgttttgt
     1921 tgaaccgcta aggaattggt aaccagtagt tgtgtccatg aagacaactg ggcgatattc
     1981 tggatggata tcttttttca ttttgcaata tttcctttct gccatggtct ctttgcgagc
     2041 catagattgt taccatacta gtctatcaga ttctgaaaag tttggcaagt attttatcag
     2101 tttttaagca agttttttaa cttttggtag atgatttcgt tttcttctag gctataggaa
     2161 ttagcaccac ttgctagagg gtggcctcca ccatcatgct ccttggcaat ttcattgata
     2221 ggatggactt tactgcgtaa gcgaactcgg tagtggccat cagcctgttc gacaaaaatt
     2281 ccccagagac tcactctgtc aatgcgtcca ggtgcaccta caatggccgc agtttcagca
     2341 tcggttatat tgtattgttt caagattttc tgactcagga taacgcgagc agcaccattt
     2401 tcatccactt ccagatggtc gtagatgtag ccttgcagtt tagcaatttt gtagctcata
     2461 gtgtccattt tgcgagtgag agccgcaaag tcaaagttat gttctctcaa ataagcagcc
     2521 aggcgaagag tccgtgcagt ggtagaaggg tagaggaagc gacctgtatc accgacaatt
     2581 cctgcaaaga gcaactcagc atcgcgatct gccaaggcta gttgggttgt ttgggcaaat
     2641 agggtaatca tctcgctagc gctacttgaa ctagtatcga cccaagacag gtcaccgtat
     2701 acatcatcat ttggatggtg gtcaatctta atgagaaaat caccttgact atagcgctta
     2761 tcatcgatac gagcagtatt agctgtatca cagacgatga caagtgcgcc ttggtaggct
     2821 ctatcttcaa caagatccat ctcagccatc caagtaagag ttggttcatc aaaaccgacg
     2881 gctttgatgg ttttttctgg gaaatgatgt tccagcaagg ctttcaatcc cacctgactt
     2941 cccaaggcat cagggtctgg tttcatatga cgatgaatga taatggtgtc gtattcttta
     3001 attttttcta aaatttgttg gcaaatctcc ataaataacc tcaattcttt ctcatttcat
     3061 tgtagcacaa gaatttttat ttttaaaatg aaaaagatgt gatataatgg agaaagataa
     3121 attgaggagg acgatatggc attagcaaaa attgtatttg ccagtatgac cggtaatacc
     3181 gaagaaattg cagatattgt agcagacaaa ttacgtgact tgggcttgga tgttgatgtt
     3241 gatgaatgta caactgttga cgcttcagac ttcttggaag cagacatcgc tatcgttgcg
     3301 acctatactt atggtgatgg tgaattgcca gatgagatga tggacttcta cgaagaccta
     3361 gcagatctca acttgaatgg caaaatctac ggagtggtcg gctcaggaga taccttctac
     3421 gatgaattct gtaaggctgt tgatgacttt gaccgtgtct ttgtgtcaac aggagcagaa
     3481 aaaggttcag agtgtgttaa agttgatctt tctgccgagg aagaagatat tgaacgcttg
     3541 gaacaattcg cagaagaatt ggctgctaaa gtaggataaa cataaaagtg cgctgatgta
     3601 atcaatcagt gcatttttct tatcgagagt tgggatttta ctagcctaat tgatggcttt
     3661 ttgatacaat aattcaaata aaggaggaga ctgtatggat ttagatatta ttcgtcaaga
     3721 aatcgatcaa atcgacgacc aaattgtcaa actgttagaa gaacgaatgc atttagttga
     3781 gggggtggtt gcttataaga aagcttcagg taaaccgatt ttagatacta agagagaaga
     3841 agttattttt gaaaaggtta ggagtcgtgt agaggacaag cgctatcagg agactattgt
     3901 cgcgactttt tcggacatac tcaaacgttc gcgtgattat caggatcaaa atatcaaatg
     3961 aaaaaagaac aattttatcc gctaggaatt tttctagctg ctatgttggg cggacttgtc
     4021 cgatatctag tttccacctg gttaccagcc agtccagact ttccttgggg cactctcttt
     4081 gtcaactatc tgggaatttt ctgcttgatt tttcttgtca agggctatct ggtctataag
     4141 gggactagta agggcttgat tttagcactg gggacgggtt tttgcggagg tttaacaact
     4201 ttttccagcc taatgcttga tactgtgaag ctgcttgata cagggcgtta tcttagttta
     4261 gtcctgtatt tgcttttgag catcggtgga ggcctactct tagcttattt tctagggagg
     4321 aagaaatggt aatcgtctat cttgcaattg cttgtggttt cggagcactc gtacggtatt
     4381 tcttttctcg ctataatcaa gcttctaaat tgccactcgg aacgctcata gctaatcttt
     4441 taggttgttt tttaattgga gtattctaca atcatgtaga gtctaaggaa gtatatgcta
     4501 ttctagcaac aggattttgt ggcggtttaa caactttttc gaccttgaat gacgaacttc
     4561 aaagactgct aagtgataag aaggtctttt attcttacct gactttgact tacataggtg
     4621 gtttggttgc gattttttta ggaattttgc tataaatttc tttacttttt tttagaaatt
     4681 tggtaaacta tatcttgtgt gtaatggacg cacaaaaata cagtttatcc gctgaggaag
     4741 attcctcaag attgacaaag ataggagaat aaaatgaatc cattaatcca aagcttgact
     4801 gaaggtcaac ttcgtacaga tatcccatca ttccgtcctg gtgacactgt tcgtgtacac
     4861 gcgaaagttg tcgaaggtaa ccgtgaacgt atccagattt ttgaaggtgt tgttatcgca
     4921 cgtaaaggtg ctggaatctc agaaaactac acagttcgta aaatctctaa cggtgtaggt
     4981 gttgagcgta tcttcccaat ccacactcca cgtgttgaaa aaatcgaagt tgttcgttac
     5041 ggtaaagtac gtcgtgcgaa attgtactac ttgcgtgctc ttcaaggtaa agcagctcgt
     5101 atcaaagaaa tccgtcgtta attcgactaa aaaactctgc ttttcagcag agtttttatc
     5161 tagctccctt agttcaatgg atataacaac tccctcctaa ggagtagttg caggttcgat
     5221 tcctgcaggg ggcagtaatt agacatcaaa aaccgctcag ctgagcggtt tttatctatt
     5281 ctttcctttt acagtaccaa tgtacgaata gcatgggcaa cgccggattc gtcatttgtt
     5341 ttggtgatgt atttggcgat ttttttgatt tctggatttc cgttttccat gactacaggg
     5401 ttgccaacga cttccagcat ggcacggtca ttttcttcgt ctccgatagc catggtttca
     5461 tctttggtta atcctagttt ttcagctaag tgagtaatag ctgaaccctt gtctacattc
     5521 tttttaagga gttcgaggta gaaaggagca gatttgttga tagagtagtg ctcgtaaaat
     5581 tcggctggta ttttttcaat cgcagcatcg aggatttctg gttcatcgat gaacatacac
     5641 ttgacaattt ccttgccagc catttcttca ggagtgcggt agaagatagg catgctgacg
     5701 agggttgatt cgtgcacagt gtatgttccg atattgcgat tggcggtata gataccgtcc
     5761 ttagtaatag catgcatgtg aacaccaagc ttgcgactga gaaattccat atccagataa
     5821 tcctcatagg tcaaggattc gctgataatc tcatggccag tatcagtctc ttggacaagg
     5881 gcaccattga aggtcaccac atagtcacct tggtctctca actgcaagtc gtccagaagt
     5941 ttggcaacac ctgcgatggg gcggccagtt gcaatcacga ctttgacacc agcttctttg
     6001 gcatcttgga tggcagaaaa gacttcagga gtgatttcct tttggctgtt gactagggtt
     6061 ccgtcaatat cgacggcaat tagtttaata ctcataaaat tcctcttcta gtttttattt
     6121 ggggtaaaat gatcgttctc aatcaagtgt aaaaattgct gggtaatgct tgcaaagatg
     6181 ctgttttggt ccaacatttc ttttggaaaa taaaagcgat tatctccgtg gcgactgcca
     6241 gcaagggatt ggacgatagg agacaggcta gagagttcgg ccagttctcc atttttttgt
     6301 aaaatctcaa tctgtgtccg tgggttttca gattcgggac gatagatatc ataagggagg
     6361 tcaaagttct tatgaatggc agtgtagtag tcgggatcaa agccgatatc ctcaaccaat
     6421 tttctcatgc tagtaagttg atcttggtcc tcttgtgaaa aggtaatgga tttaaagacc
     6481 ttgcggttga caaagcgatg cgataaatct gcaagaatct tgtcaggact ggtcatccaa
     6541 agctggaagt aggtattcat cacgccatca tccagagcca gatagtcagt caaggtcaca
     6601 tttttttcga agaaaggcag gaggtgtgga gaagttcggg caaagaaatc cttgtcctca
     6661 ggatagagtt ccttggcgcg tttgagaaga ttctgtagga gaacttccat ggcgcgtgtt
     6721 gcggggtgga aataaacctg catgtacatc tggtagcgac tgaggacgta gtcttcgatg
     6781 gcgtgcatgc cattgcgctg aaaggcgata ccattttcga taggacgaat gactcggagg
     6841 attcgagtca ggtcaaattc cccataggat gctcctgtaa aataggagtc acgcaagaga
     6901 tagtccatgc ggtccgcatc aatctggcta gaaatgagct gcacgacctg cttattagga
     6961 taggtatggt caatgacact ggccaccttt tctgggaaat caggtgtcac ttgtagcagg
     7021 acttggtgaa tctctgtctc aggattttga ataatctcct gagtaatggc ttcatggtct
     7081 gtatcaaaga gattttcaaa agtatgggag taggcaccat gcccaaggtc gtgtaggaga
     7141 gcagcggtca tggtcaagag agactcggca ggattccatt cctcaggata tttttcttcg
     7201 aaaatctctg tgatgcgtcg tgcaatttca tagactccta gacagtgaga gaagcgacta
     7261 tgctctccac cgtggaaggt ataactggaa gttcccagtt gtttgatccg gcgcaaacgt
     7321 tgaaattctt ttgtattaat caagtcatag atgatttgat tattgacatg gatgtagttg
     7381 tgaacagggt cacggaatac tttttcgttc atatgaccat tatagcaaaa tcctgctctt
     7441 tttggtaaaa tagtaggaca agagacaaga aagagggcct gatgtgaaga ttcggatgcg
     7501 aaatacaatt cagtttgatg agcagttgga agtgattgac cagctttatg atgtggaagt
     7561 gcatgaaaaa ggagattata gctacctgct tttctataat gaggaaaagg aaaaagtagt
     7621 gattaaattt catggtcaag aacttgtgat gagtcgattt tccaatccca agaccattat
     7681 gcgctttcta aaggatagtg atagtttagc ctatattccc acacctatgg gtatgcagga
     7741 gtttattatc caaacgaatc gttatcaagt ggatgggcaa aagattgaac tagattatca
     7801 actacaaaat caagagggac atccctttgc cagctatcaa ttggaaatta cttggggcta
     7861 ggctcatgtc tttttcaaat ttagctatct atcttcttgg atcggcttcc tagtgtggta
     7921 gattaggcta atttttggta taataaaagt tatggaaatc gaaaaaacca atcgtatgaa
     7981 tgcgctcttt gaattttatg cggcgctttt gacagataag caaatgaatt atatcgagct
     8041 ctactacgct gatgattaca gccttgctga aattgccgag gagttcggtg tcagtcgtca
     8101 ggctgtctat gacaatatca agcgaacaga aaagattctg gaagattatg agatgaaatt
     8161 gcacatgtac tcggactata ttgtccgcag tcagattttt gatcagattt tggagcgcta
     8221 tcccaaggat gactttctgc aggagcagat agaaatttta acaagcattg ataatagaga
     8281 ataagaggaa gaaaaatggc atttgaaagt ttaacagaac gtttgcagaa cgtctttaaa
     8341 aatctacgta aaaaaggaaa aatctctgaa tctgatgtcc aagaggcaac caaagaaatt
     8401 cgcttggcct tgctcgaggc cgacgttgcc ttgcctgttg taaaggactt tatcaagaaa
     8461 gttcgtgagc gtgcagtcgg gcatgaggtc attgatacgc ttaatcctgc gcaacagatt
     8521 attaaaatcg ttgatgagga actgacagcc gttttaggtt ctgatacggc agaaattatc
     8581 aagtcaccta agattccaac catcatcatg atggttggtt tacaaggggc tggtaaaaca
     8641 acctttgctg gtaaattggc caacaaactc aagaaagaag aaaatgctcg tcctttgatg
     8701 attgcggcgg atatttatcg tccagctgcc attgaccagc ttaagacctt gggacaacag
     8761 attgatgtgc ctgtctttgc acttggaaca gaagtaccag ctgttgagat tgtacgtcaa
     8821 ggtttggagc aagcccaaac taatcataac gactatgtct tgattgatac tgcgggtcgt
     8881 ttgcagattg atgagctcct catgaatgag cttcgtgatg tgaaagtatt ggctcaacca
     8941 aatgaaatct tgcttgtcgt tgatgctatg attggtcagg aagcagccaa tgttgcgcgt
     9001 gagtttaatg ctcagttgga agtgactggg gtcatcctta ccaagattga tggtgatact
     9061 cgtggtggtg ctgctctgtc tgttcgtcac atcactggaa aaccaatcaa gttcactggt
     9121 acaggtgaaa aaattacaga tatcgaaacc ttccacccag accgtatgtc tagccgtatc
     9181 cttggcatgg gggatatgct cactttgatt gagaaagctt ctcaggaata cgatgaacaa
     9241 aaagcccttg aaatggctga gaagatgcgc gaaaacacct ttgattttaa tgatttcatc
     9301 gatcaattag atcaggtgca aaatatgggg ccgatggaag acttgctcaa gatgattcca
     9361 ggtatggcca acaatccagc ccttcaaaac atgaaggtgg atgaacgcca gattgctcgt
     9421 aaacgtgcca ttgtgtcttc gatgacacct gaagagcgtg aaaacccaga tttgttaaat
     9481 ccaagccgtc gccgtcgtat tgctgctggt tctggaaata cattcgtcga agtcaataaa
     9541 ttcatcaagg actttaacca ggctaaacag ctcatgcagg gtgttatgtc tggggatatg
     9601 aataaaatga tgaagcaaat ggggattaat ccaaataacc ttcctaaaaa tatgccaaat
     9661 atgggaggaa tggatatgtc tgcccttgaa ggaatgatgg gacaaggcgg tatgcctgac
     9721 ttatcagctc tcggaggagc aggaatgcca gatatgagcc agatgtttgg tggcggtttg
     9781 aaaggtaaaa ttggtgaatt tgccatgaaa cagtccatga aacgtatggc taacaaaatg
     9841 aagaaagcga agaagaaacg caagtaagac aagagattga tgcaaatctc atttgatgag
     9901 aaaataaagt aaaaatttct atgataaaac gtacagtatc aaggttttag aatatctgat
     9961 attatacgtt ttttgatttt aataattttg ttaagacact tttattatgg tatacgaaaa
    10021 atccactcag ctgtctgagt ggattaggtg tatttagact cttagtcttt attttcgtat
    10081 ggcaagatca agttcaagat gattcctgtc atggctgaaa gggcagtacc tgaaagtgta
    10141 actggaccaa gtttaaggat agctcctcca agtccaagaa ccaacatagc acttgcgatg
    10201 atgaggtttc gcatttgagc gaaatcaaca cgttctttaa tcaagacttt caaaccattg
    10261 ctggcgataa ccccatagag aaggattgac ataccaccaa gtacagcgtt tggaatagtt
    10321 gaaatcaagg cagtgaattt accaaggaag ctgagggcaa tcgcgatgaa ggcagcgtta
    10381 cggataactg agacagaagc gatacgagtc ataccgataa cccctgtatt ttctccgtaa
    10441 gttgtattgg ctggtccacc aaggaaggca gaaacagaag ttgcgatacc gtcaccaaga
    10501 agagtacggt gaagacctgg ttcttttaag aattgacgac cacagatttg acccaaaaca
    10561 gtatggtctc cgatatgttc agaaattgtt acgatagcga ttggcaagat agcgatggct
    10621 tctggaccaa agtaaagatt gtactcttta aaggcaccac ctgtgctaaa tggcaagtag
    10681 aaaccaggaa tttcaaacca gttagcttct aggacaggcg taaagtcaac caaaccaaga
    10741 gttagtgcga agaggtaacc accgataatg gcaaagagga atggaatgat tcgtaggaag
    10801 ccttttcctt ttgtattgat aaaggcagca attaggaaag taacaacggc taccagagca
    10861 tttttccaat ttccgtctgc tacaagacct gcattggtaa cagctgaacc tgcaagtcca
    10921 agaccgataa cgatgatcat aggaccgata atgattggtg gcaagagttt atcaatccat
    10981 tttgttccta caaatcggat gctggtagca acaaggacat agaccaaacc agtcaagata
    11041 acccctgttt gagcagcaga tacatccccc cccatttctt tcatagccag tgacatagct
    11101 gtgataaagg cgaatgaaga acctagataa actggaactt taaaaccagt agcaagcatg
    11161 tagatgagtg ttccaacacc tgaagcaaaa agggcaacag atacaggcat tcccaaaatc
    11221 aatggtacca agatggtcgc accaaacatg gcgaaaacgt gttggaaact aaggagaatt
    11281 ccttttccag ccgaaggacg ttggtcaacg tctagtaaca aatcaacagt tgattcttgt
    11341 ttcatataaa cctcactttt gggcatcaaa aaagagccca ttattttaca gcaataggcc
    11401 ctcagagtaa gacttcttta aaatttagat tttaaagagt tttaaatatt tctgcgtctt
    11461 cgtcacctca cgggatgaca ttaaaaacct ttgcttagga tagtatagca gaaaaaaatg
    11521 attttgtaaa tcattttttc ccgagcctag aaataaaaga gcgaggctga ttttgtaaac
    11581 atttgtttac taaaaaattt aaagtgggcg tttatttggc ataccagcct tacgtggata
    11641 tttatttggt gtttcttttt tcttttctac cactgtgata tagcgcggat ctctattcgg
    11701 tagggcgtag ctgagattgt cttcgacctt actaaaaagg agattgaggg cattcttagc
    11761 ttctaataat tcctcaggcg cattgctggc cttgagtgcc aatagttttc caccaacctt
    11821 aaggtaggga atggtcaatt cagataggac ctgcatacgg gcaaccgcac gagctgttac
    11881 aaaatcatat tgagcacgga agttcttgtc ttgggcaaaa tcttcggcac gtccgtggta
    11941 gaaatgaact ccgttcaaat ccagttcttg agccaagagt tgtaggaagt tgatgcgctt
    12001 attgagtgaa tcaataatgg tcacatctaa ctccggatag agaattttca ttggtagact
    12061 aggaaatcct gccccagccc cgatatcaag aagtttgata gtttcattgg gaatcaaacc
    12121 ttgaagaatg ggtgcaatcg aatcgtaaaa atgtttgaga taaacttctt ccttgtccgt
    12181 aatcgccgtc aaattaatct tctcattcca ctcgaccaag agctcaaaat aacgttcaaa
    12241 ttgttctttt tgctggtccg aaagtggaag attctgctcg gcaagcaagt tgtaaaatgt
    12301 ttttggtttc atagttattt ccttctttag tatcatctta ttttaccaca atcatagaaa
    12361 atttgatata ctggtactaa tctaaaagca gaaaggactt atattatgac ttggattatt
    12421 cttggagtta tcgctcttat tgttattttt gtgattgtta gctataacgg tttggttaaa
    12481 aatcgtatgc aaaccaagga ggcttggagt cagattgatg ttcagttgaa acgtcgaaat
    12541 gacctcttgc cgaacttgat tgagactgta aaaggttatg ccaaatatga aggttctacc
    12601 cttgaaaagg tggcagaact acgtaaccaa gtggcggcag cgacttcacc agcagaagct
    12661 atgaaagcca gtgatgccct cactcgtcag gtttcaggta tttttgcagt tgcagaaagc
    12721 tatccagatt tgaaagctag tgctaacttt gttaaattgc aagaggagtt gacaaacaca
    12781 gaaaataaaa tttcttactc tcgtcaactc tataacagtg ttgtcagcaa ctacaatgta
    12841 aaattagaaa ctttcccgag caatattatc gctggaatgt ttggatttaa agcggcagat
    12901 ttccttcaaa cacctgaaga ggaaaagtcg gttcctaaag ttgattttag cggtttaggt
    12961 gactaagatg ttgtttgatc aaattgcaag caataaacga aaaacctgga ttttgttgct
    13021 ggtatttttc ctactcttag ctcttgttgg ttatgcggtt ggttatctct ttataagatc
    13081 tggacttggt ggtttggtta tcgcactgat tatcggcttt atctacgctt tgtctatgat
    13141 ttttcaatcg acagagattg tcatgtccat gaatggagcg cgtgaggtgg atgagcaaac
    13201 ggcaccagac ctctaccatg tagtggaaga tatggctctg gtcgctcaga ttcctatgcc
    13261 ccgtgttttc atcattgatg atccagcctt aaatgccttt gcgacaggtt ctaatcctca
    13321 aaatgcggct gttgctgcga cttcaggtct actagctatc atgaatcgtg aagaactaga
    13381 agctgttatg ggacatgaag tcagtcatat tcgtaattat gatatccgta tttcgactat
    13441 tgcagttgcc cttgctagtg ctatcaccat gctttctggt atggcaggtc gtatgatgtg
    13501 gtggggtgga gcaggtcgca gacgaagtga tgatgaccga gatggaaatg gtcttgaaat
    13561 cattatgcta gtggtttccc tactagctat tgtactggca cctctcgctg caaccttggt
    13621 tcagctcgct atttctcgtc agagggaatt tctggcagat gcatctagtg ttgagctgac
    13681 tcgcaatccc cagggaatga ttaatgccct agataagttg gacaatagca aaccgatgag
    13741 tcgccacgtc gatgatgcta gcagtgctct ttatatcaat gatcccaaga aaggtggggg
    13801 gttccaaaaa ctcttttata cccacccacc tatctcagaa cggattgaac gtttaaaaca
    13861 gatgtaaaag aatccagagg tcgtctctgg atttttgcta tgttgcaaat ttataaatct
    13921 tctaaattaa ctagcttcaa accgtgttct gtcatgcgat agatgatcga gcagacttct
    13981 tttaagaaac gacggtcatg cgaaacagtg atgagaccgc ctggataggt tgcaaagagt
    14041 tttctgattt ggggttgaga agtgggagaa aagtttcgtg tgggttcatc cagcaggaga
    14101 aagtttggtt tgcgcaggac tagatccaaa agcaggagtt ttccctgttg tccgccagat
    14161 aaggagcgaa tttgatgctg catttctgga taactgaaat tgagactggc taggtgagag
    14221 tggattttct gaagttcctc tttttcccca gttttgctga tataagctat tggtgataaa
    14281 tccaattgta gttttttgtg gtaatcttgt ggcataaaac caagggaaat ctctctttta
    14341 tcattcagaa gttgctttaa tttggctaac agagttgatt tcccaacacc atttggcccg
    14401 ataataccga ttttttcttg cccacggaca gttagttgta gtttttgaac caaaactcgg
    14461 tcgtcaatgg acaaattttc tttttccagt tggactaaga ctttagaagc tggtaatggt
    14521 tggatgtctg aaaagaaaag ttggatttgt tcctcttcaa gtggtttttg agtcatggac
    14581 tgagctgcct tttcgtagcg tttttcttgt gagaggacag ttttcatctt tttagacaat
    14641 aggcgaccgg cagtactatc tttggtagct cgaagcgcag tttctacatt ttgcttaact
    14701 ctccgatgtt tttccatggt tttatcgtag gctctttggt tgttagcagc ttgctgactt
    14761 tgtttggcaa aattagcctt tctctgctca ctatagctat catagtctaa atgctctact
    14821 agcgtttccg cttctttacg gtgtttgacc agtcgcaagt gaacaatagt gtctgccgtt
    14881 tcagaaagaa agtcttcatc atgggaaatg aaaataacgg tttgcctggt cttttgaatc
    14941 tggcctttta gccaatcaac tgtctcaagg tctaggtcat ttgaaggttc atctaaaaat
    15001 agaatctcaa agggtttggc taactcatgg ataagctgaa ttttcaaagc ttctccccct
    15061 gatagattgc caatctcttg gtcacttgcg aaacgattgc tatcaaaatg caattcctcc
    15121 gccaaacgat agaggatact gtagtctaaa tcaatagaat ctaaaaagaa gtagtcgtgt
    15181 aaagttttct ttttcagctc ctcgggaagt ttttgaggaa tgtaggccag tgactgatag
    15241 tcagattgga tgtttccctt gatagtgaaa tcagacaaag cttcccccat taaaatttta
    15301 agtaaggttg atttgccatt tccttcttca ccaataatag caaccttttc cccgtcttgg
    15361 atggtcatgg ttaggtcaga tacaagatct cgtaaatctt tgttttgtgt gatggttaga
    15421 tgattgattt ttatcatatg atttcccttt ctagaatgtt catagtgcat aacaaaaagc
    15481 tctactttac ctagtagagc ccaaagtcta tgtcaaaaaa actctattaa catgccagaa
    15541 aaagagcata aaagagcaca caaaaagaga caaaaacaag atctactaaa taaaggttct
    15601 ttatttgata gacttagttg ttcatgtctc ccttacctcc gagtattagt atctttatat
    15661 tataccttta aggaaatttt gtcaacagaa aactggaaat tctatgctct aaaattcaaa
    15721 aacaggtcca tagagactta gtacgtgttt gacatgctcg taatggaatt tatcatagtt
    15781 tcgccaagca gtgcgtgctt gatcgtttag ttttaggcta cccagtccaa tcagaagact
    15841 ggtaggttgg taaaatttct caagatcaat taagatactg ttgttcaact gttccgtttt
    15901 tttgagctct tgcatagtag tgtttagcag ctcttgtagt cgaatatcat ctgccgtacc
    15961 ctgtttacag ttttggtagc ttttatttaa cttggatagg agttgaatga gtttcttgtc
    16021 ttccatgtga gcatcctcct tgatctgatg tactctttcc ctatagtata gcactaaaaa
    16081 ataaaactat aatagtaaat atgttaaaat tttgaatttt aattacaaag tttggtgtgc
    16141 tgatttgtag ccttttcatg gtataatcaa gagagtaaat ctttatggag gaagtatgaa
    16201 attaaatatt caagaaattc gtaagcagtc tgaaggtttg aactttgaac aaacgttaga
    16261 tttagttgat gacctgcgtg cacgtaatca agaaatttta gatgtaaaag atatccttgc
    16321 agttgggaaa gtacaatatg aagaccgtat gtatttctta gattatcaac tatcttatac
    16381 cattgttctt gcttcgagtc gcagtatgga gccagttgag ttagttgaat cttatccagt
    16441 cacggaagtt ttcatggaag gcgcaactaa ccagctagat caagaagttt tagatgatga
    16501 cttggtcttg cccatcgaaa atggggagct tgaccttgct gagagtgtat cagacaatat
    16561 cctgctaaac attcctatca aggtcttgac ggctgaagaa gaagctggtc aaggatttat
    16621 ctcaggaaat gactggcaaa tcatgacaga ggaagaatac caagctcaaa aagcagtaaa
    16681 gaaagaagaa aacagtcctt ttgctggctt acaaggacta tttgacggag atgaataatg
    16741 gtcttgtcaa aaaaacgagc acgaaaggtg ctagaagaaa tcattaccct cttcccagat
    16801 gccaagccta gtcttgattt taccaatcat tttgaactcc tggttgcggt catgttatca
    16861 gcccagacga cagatgcagc ggtaaataag gccacaccag gtctctttgt tgcctttcca
    16921 acaccccaag ctatgtctgt agcgacagag agtgagattg cttcacatat ttctcgcttg
    16981 ggattgtatc ggaataaagc taaattcctt aaaaaatgtg cccaacagtt actagacgat
    17041 tttgatggtc aagtccctca gacacgtgaa gaattggaga gtttggcagg tgttggtcgc
    17101 aagacagcca atgttgtcat gagtgtagga tttgggattc cagcctttgc agtggatact
    17161 catgtggagc gtatttgcaa acaccacgat attgtcaaaa aatcagcgac gccacttgag
    17221 gtggaaaagc gggtcatgga tatcttgccg cctgagcagt ggttagctgc ccatcaggcc
    17281 atgatttatt ttggaagagc catttgccat ccaaaaaatc cagagtgtga ccagtaccca
    17341 caattatatg attttagcaa tttgtaagat gctacattga aactttttgc ttgattttaa
    17401 gcatgctttg tgctatagta aatgataact aaatattcct ttaaacctgt cccgtgaggc
    17461 aggcaaggag cgcgataaag tagaagggtg aagtctatac tgtgtgcagt agggctcgct
    17521 tggctataaa tttcaagtct ccttgtttaa ggagactttt ctttttggag gtttgtcatg
    17581 aaaacaaaag aagttgtaga cgaattgacc gtcaaacgag cgattacgcg tattacttat
    17641 gagattatcg aacgcaacaa agatttgaat aagatcgtct tggctggtat taaaactcgt
    17701 ggtgtcttta ttgcccaccg aatccaagaa cgtttgaagc agttagaaaa tctttcagtt
    17761 cctgttgtgg aattggatac taaacctttc cgtgatgatg ttaaaagtgg agaagatact
    17821 tctttggttt ctgtcgatgt gacagaccgc gaagttatct tggtggatga tgtgctctat
    17881 acaggtcgta ccatccgtgc tgctattgat aatattgtcg gtcatggtcg tcctgcgcgt
    17941 gtgagtttag cagttctagt cgatcgtgga catagagaat tgccaatccg tccagattac
    18001 gttggaaaaa atatcccaac cagtcgttct gaagaaatca tcgtagagat gacagaactt
    18061 gatgaccaag acagagttct gattactgaa gaagcttaga aagttaaagg agtagccatg
    18121 tcagaaaatc aacaagcatt gaaccatgtg gtgtccatgg aagacctcac tgtcgatcaa
    18181 gtaatgaaat tgatcaagcg aggaattgag tttaaaaatg gagcccagct tccctatgaa
    18241 gaccatccga ttgtttccaa tctcttcttt gaggattcta cacggacaca taagtccttt
    18301 gaagtcgcag agattaaact tggattggaa cgacttgact ttgatgtgaa gactagttcg
    18361 gttaataagg gtgagacact ttatgacacc attttgactc tgtctgcttt aggagtggat
    18421 gtctgtgtga ttcgccatcc agaggtcgac tactatagag aattgattgc tagtccaacg
    18481 attacgactt ccatcatcaa tggtggagat ggttcgggcc aacaccctag ccagagcttg
    18541 cttgatttga tgaccattta tgaggaattt ggccactttg agggtcttaa agttgctatt
    18601 gcaggtgact tggatcactc acgcgttgcc aaatccaata tgcagatttt gaaacgcttg
    18661 ggagctgaac tctttttcgc tggacctgag gaatggagaa gtcaagagtt tgcagactat
    18721 ggacagtttg taaccattga tgaaatcatt gatcaggttg atgtcatgat gtttctccgt
    18781 gtgcaacacg aacgccatga tagtggagct gtattttcaa aagaagacta ccatgcccaa
    18841 catggcttga ctcaagaacg ttacgatcgt ttgaaagaaa cagcaatcct catgcaccca
    18901 gctccaatca atcgtgatgt agaaatagca gaccacttgg ttgaagcacc aaaatcacgg
    18961 attgtccaac aaatgaccaa tggtgtcttt gttcgaatgg caatcttaga atccgtacta
    19021 gcgagtagaa acgccaacta aaacacaaga cgttaaaaga cgccagtgag cgtccacgag
    19081 aggtgaaaat atgacaaaaa gaattctagt attagaagat ggcacagttt ttgaaggcaa
    19141 ggccttcgga gcagatattg atgtaacagg cgaaatcgtc tttaatacag ggatgaccgg
    19201 ctaccaagaa tccattacag accagtctta taatggacaa atcttgacct ttacttatcc
    19261 tttggtagga aattatggta ttaatcgtga tgattatgaa tccattattc caacttgtaa
    19321 gggagtcgtt gtttttgaag aagcgcgtag agctagcaac tggcgcaacc aaatgacctt
    19381 ggatgaattt ttgaaagcca aaaaaattcc agggatttca ggaattgata cgcgtgctct
    19441 taccaagatt atccgtaagc atggtactat gcgtgcaacc ttgacccatg ttggggacag
    19501 tatggaccat gtgacggacc agctccaagc aacagtttta ccgacagaca atatcaaaca
    19561 ggtttctact aaaacgtctt atccagctcc aggagttggt ttgagcgtgg tgctagtgga
    19621 ctttggtctc aagcactcaa tcctacgtga actttctaaa cgcaactgta acgtgacagt
    19681 tgttccttat tcgacaacgg ctgaagaaat tctccatctc aatcctgatg gggttatgtt
    19741 gtcaaatggt ccaggtaacc cagaagacgt tccacaagca ctcgacatga ttcgcggtgt
    19801 acaaggaaaa attccaatct ttggtatttg tatgggacac caactctttg caatggcaaa
    19861 cggggctaag acctataaga tgaagtttgg ccaccgtgga ttcaaccatg cggtacgtga
    19921 aatcgcaaca ggacgagtag acttcaccag ccagaaccat ggttatgcag tcagccgcga
    19981 ggatttgcca gagcacttga ttattaccca cgaagaaatc aatgacaagt cagtggaagg
    20041 tgtgcgccac agataccaac ctgctttctc tgttcaatac cacccagatg cagctcctgg
    20101 gccacacgac gctagctacc tatttgacga gtttatcgag atgatggaag tttttaaaca
    20161 atcaaactaa gaacgagtaa aagctcgtcg gagaatttat gtaactgaac acggacggaa
    20221 agctcagaat gtagagaaat caacttggat tgtcaatcct tccttgattt tctaaaattc
    20281 aatcgctttc tattcgtcct ttgtatctta tttaatgtcg ccctgagagg cgacgaatag
    20341 aaaggagaag ggtgctccgt atttgctgaa ctgaatacgg gctacggacg gtgctaaaaa
    20401 gatagttatt cctagaactg acagttcttc gtcataactc ctattttagc tttgtccgct
    20461 tgacgccctt aatatcttat atatgcctaa acgtactgat attcaaaaaa ttatggtgat
    20521 tggttctggt ccgattatta ttggccaggc tgctgagttt gactacgctg ggactcaggc
    20581 ttgcttgtcg ttgaaagagg aaggttatga ggttgttttg gttaactcaa atcctgcaac
    20641 catcatgacg gacaaggaaa ttgctgacaa ggtttacatt gaaccgatta cacttgagtt
    20701 tgtgacacgt attcttcgta aggaacgtcc agatgccttg ctaccaacac tcggtggtca
    20761 gacaggtctc aacatggcca tggaattatc taaaaatggt atcctagacg agcttggcgt
    20821 tgaacttctg ggtaccaaat tatctgccat tgaccaagcg gaggaccgtg acctctttaa
    20881 acaattgatg gaagagcttg aacaacccat tccagaatct gaaattgtta acacagtaga
    20941 agaagcagtt gcctttgcag cgacaattgg ctacccagtc atcgttcgtc cagcctttac
    21001 ccttggtggt actggtggtg gtatgtgtgc caacgagaaa gaattgcgtg aaatcactga
    21061 aaatggtttg aaattgtcac ctgttaccca atgtttgatt gagcgttcga ttgccggttt
    21121 caaggaaatt gaatacgaag tgatgcgtga ctcagctgac aatgccttgg ttgtttgtaa
    21181 catggaaaac tttgacccag ttgggattca cacaggggat tccattgtat ttgcccctgc
    21241 gcaaaccatg tcagactatg aaaaccaaat gcttcgtgat gcgagcttga gcattattcg
    21301 tgccctcaag attgaaggtg gatgtaatgt tcagctagct cttgatccta acagcttcaa
    21361 gtattatgtt atcgaagtaa accctcgtgt atcacgttcg tcagcccttg cttctaaagc
    21421 gacaggatat ccgattgcta agttggctgc caagattgca gtaggtttga ccttggatga
    21481 ggttataaac ccagttacag gttcaaccta tgccatgttt gaaccagccc ttgactacgt
    21541 agttgctaag attccacgtt tcccatttga caagtttgaa aagggtgaac gccgtctcgg
    21601 tacacaaatg aaggcgactg gagaagtcat ggcaatcggt cgtaacatcg aggaatctct
    21661 tctcaaggcc tgccgctccc ttgaaattgg ggtgcaccac aatgaaatac ctgaacttgc
    21721 agcagtttct gatgatgcct tgattgaaaa ggttgtcaaa gcccaagatg accgtctctt
    21781 ctacgtatca gaagcaattc gtcgtggcta cacacctgaa gaaattgcag agcttacaaa
    21841 aattgatatc ttctatcttg ataaactctt tcatatcttt gaaattgagc aagaattggg
    21901 tgctcatcca caagatctag aagttttgaa aacagccaaa cttaatggtt tttcagaccg
    21961 taagattgct gaactctggg gaacgactga tgataaagtt cgccaacttc gcttggaaaa
    22021 caagattgtt ccagtttata agatggtaga cacttgtgcg gcagagttcg actccgaaac
    22081 gccatatttc tattcaacct atggttggga aaatgaatct atcagatctg ataaagaatc
    22141 tgtacttgtc ctaggttcag gtccaatccg tatcggtcaa ggggttgagt ttgactacgc
    22201 aaccgttcac tctgttaagg ctatccaggc agctggttat gaagctatca tcatgaactc
    22261 aaacccagag accgtttcaa cagacttctc tgtatcagat aagctttact ttgagccatt
    22321 gacattcgaa gatgttatga acgtcattga cttggaacaa ccaaagggag ttatcgttca
    22381 gttcggtggt caaacagcca tcaaccttgc ggagccattg gcaaaagcag gtgtgaccat
    22441 ccttggtaca caggttgctg acctagaccg tgccgaagac cgtgacctct tcgagcaagc
    22501 tctcaaagaa ttggatattc cacagccacc aggacaaacg gctaccaatg aagaagaagc
    22561 agctcttgca gctcgtaaga ttggcttccc agttcttgtc cgcccatctt atgtacttgg
    22621 tggacgtgcc atggaaatcg ttgaaaacga agaagacctt cgttcttaca tgcgaactgc
    22681 tgttaaggct agtccagatc acccagttct tgtcgactct tatatcgttg ggcaagagtg
    22741 cgaagttgat gccatttcag atggtaaaga tgtactcatt cctggtatca tggagcatat
    22801 cgaacgtgct ggtgtccact caggtgactc aatggctgtt tacccaccac aaaccttgtc
    22861 gcaaaaggtt caggagacca tcgcagacta caccaaacgc ttagcaatcg gtcttcactg
    22921 ccttggaatg atgaacatcc agtttgttat caaggatgaa aaagtctacg ttattgaggt
    22981 caatccacgt gccagccgta ctgttccatt cctatctaag gtaaccaata ttcctatggc
    23041 tcaagtagcg accaagctca ttcttggtca aagtttatca gaacttggct accaaaatgg
    23101 actttaccct gaaagcaccc gtgttcatat caaggcacct gtcttctcct ttaccaaact
    23161 agctaaggta gacagcttgc tcggtcctga aatgaagtca acaggtgaag ttatgggttc
    23221 tgatgctact ttggaaaaag ctctctataa agcctttgaa gcttcttatc tacacttgcc
    23281 aacttttggt aatgtcgtct ttaccatcgc tgatgatgcc aaagaagaag ccttgaactt
    23341 ggctcgtcgt ttccaaaaca ttggttatgg aatccttgcg acagaaggga cagcagcctt
    23401 ctttgctagc catggcttgc aagcccaacc tgttggtaag attggtgatg acgataagga
    23461 tatcccaagt tttgtacgca aaggaagaat tcaagctatc attaacacag taggaacaaa
    23521 acgaactgct gacgaagatg gtgagcaaat tcgtcgttca gccattgaac acggggtgcc
    23581 cctcttcaca gcgctagata cagctaatgc catgcttaag gtacttgaaa gtcgtagctt
    23641 tgttacagaa gcgatttaaa tagaaaaata agatatagca gactgaattt agaacagtac
    23701 acagggatac taaaatattt ctagaaatta atttgaattt tctaattgat tcgttcgcat
    23761 cttatttcaa tctactatag aaaaaagtct ttaaaattat aaaacgcatc atatcaaggt
    23821 ttttcaaaaa ccttgatatg atgcgtttta ttgtgggaat atgtatttca ttttctacta
    23881 aaattatgtt tttgaataac ctctatctta gtagtttgta taatacccct caatcagttt
    23941 ttgcgataag ctttaatgct atgactatac cactcttgca tttcttttga tggtggtgtc
    24001 atataatcgc catacatctg ggttaaaaat tggtcatatt ttttgggaac aggcaacata
    24061 cggccctcaa actcagttaa aatcagttct ttaaaggtat caactgggaa gatttctttc
    24121 atcccttcct taccgatccc aactcctcct tcatattgag gagtgttggt tacagcattt
    24181 ttgactagtt gatcaatttt cttgtaaaag tagcgaggat tgacaaatcg gagagcgtac
    24241 cagctacata atctaagaaa atcttttagt ttgctatcac cgtgaactgc tcgtgatttt
    24301 ttgatataag ctagttgacg aagagccaca tacttatagc tcttgtcgac aatgctcaag
    24361 tctgtaaatc gatcaattgg gaagacatcg atgaaaaggc tggtatcatg acgcttgtac
    24421 ttaacatggt cttctataac agtagaagtg tccaaaatcg atgcgaaatt atggaagtac
    24481 caagaagatg tatcgtagga aagaaccttg tagcgagggt gattttcttc ttcaataatc
    24541 ttcagtaaac gctcataatc ctcacgataa agggaaatat caatatcatc atcccaagga
    24601 atcatacctt tgtggcggat ggctccaagc atggttccat aactgagaaa ataaggaata
    24661 tcatgtttct tacaagtctc atcaatatag tccagcaggg ctagttgaat ttctttaatt
    24721 tctttttttt ctaaatattg catcctaatc ctccaattta taagcgtgaa attcatgact
    24781 gtagaagcgt ttttcttctg gtggtagggt catataatct ccataaaatt gtgtcaaaat
    24841 agtatcaaat ttttcaggtg caggaaggct taaattctca aagggtaaat cgattgtttt
    24901 atcaaaggta ccacttggga agacttcctt ttccttaaat tttgaaggaa taaaagccat
    24961 atactgccca ttttcacgac tatatttttg aatttctttc tcgattttat ttgcaaaata
    25021 acgaggagaa accggtcgaa ggagcaacca aaaggctgtt cgtatccaat cttttaaaag
    25081 gctatcctta tagacaatat ttttatgttt actgaaagac agcagtttga agctttccag
    25141 tttataacaa gtatcaatga ccttaggatc atcaaagcga tctataggga aaatatcgat
    25201 aaagatacca gactcatagg tttttgtatt tcgagtatca ataattttag ttgtactgtc
    25261 ggttatcttg ataaagttgt taaagtagtt cttatcagtt tctaaggata ggagcttata
    25321 cttgcttttt tccttttgaa aaatgttaat aaatcgttgg tagtcttctc taggcatgga
    25381 taaatcaata tcgtcgtccc aagggataaa gccctcatgt cgaaccgccc caatcagagt
    25441 accgtagtta ataatatagt tgatattgtg ctttttacag agagtatcaa tataattcaa
    25501 aatttctaat tcaatttgtt tggcatcttc aacggttagt tgtttcattt taaactccta
    25561 agatttttta aatttatttt ttaaggctag gacatggttt aaaaattcat agaaaatgct
    25621 atcttttgtg aagacaagta gactaatata agagatagct gatagcaaga caatcaaacc
    25681 agtattaatc aaaaatggca aattaatgac catatccaca ggatacatga aattaatcag
    25741 gaaataaatt gctacaaagg aaagtgaaaa gagagagtat cgaacagtat agctaaagat
    25801 atgtcccaag tggatgagtt gttttctatg gatgaaaatg atatagaaaa caagtagaga
    25861 agtctctgat aacatagttg tcagtaagta gtattcagga gccacgatat ggttgaaaaa
    25921 gaggagacta ttcaagccca aattgagtag cccagcaaag actgtataga ctgtgatacg
    25981 tttttcatag ccattggtaa agagaatttg ggaaccaaga atggtatcta aggccaggat
    26041 aatcgtacga aaagcgaaga gagaggtcaa gatgccgcct ccgatatatt tttcactacc
    26101 gtaaagtagg atggcatttg gtcctaaaac catgagtcca aaactcagtg gaatgataaa
    26161 gaagttaaag attcgactac ctctattaac cagagaaaca taggcttctt tgtctccttt
    26221 ccccagatag taactgagac gaggcacact cactccaatt gcacctgtta caaccccagc
    26281 tataacggtc acaattcgct gagctatggt atagtaacta acgttgacat caatccctgt
    26341 tttaacgagg aagaggcgat ctaaaaaagt gaagagcata ttggcattgg caaagactaa
    26401 catggctgtc agagggagaa agagtggttt aaaatcactt aggtgaattt taacaagttt
    26461 gatgtctctt ttaatccaaa aataactaat caggtagtta atcagcgtcg ataaactcat
    26521 cacaagtgta tagacaacaa tatcgtgttc atttttaaca aataagaaaa tagagaccag
    26581 catcaggata cggatgaagg cagttttgta aaagagaaaa ctgtaatttt ccagagcttc
    26641 attgacccat tcgattgaaa aaatctgggc aatgagttga atccccataa caaggtagac
    26701 ctttttgacg attggattat cagtaaagaa gagaggatag gctaggatat agacagcagt
    26761 ggtcaaaatc gtacaagcga tgcacaaata aaaaagacta gaaaaggttc tgttaagatc
    26821 ttttttgtta tccttgacat tactgatagc ccttaaaccg tagttataga caccataagt
    26881 tgcaaagggc aagaaaaatg acaaaatagt gtcgactgag ttgaagtaac catagtcagt
    26941 tcggtccaag acacgcgcga cataggttcc agttaggatg ggaaaaataa tattcaagac
    27001 acgaattccc atgtaagata gagcatttaa ttttatactt ttcattcaat ttacctcgtt
    27061 tttcattata tcataaagtt agctaataag aaatgaaggg cagtaagtca agtaatcact
    27121 ttgaagtttc aaatcttaaa ttttaagttt tctttaagga aagtatatta ttctgaagga
    27181 ctctaaaatt tcgcagccat ttattagtaa ttgctacaga attcctagtc attactagaa
    27241 atgaactagt ttctttgaat aatagaactg cataattctc ctattctaga aggggaggac
    27301 cagtatttct tttatgatag gactagattg tggtataata gagagaataa gtttttttag
    27361 taagacaaag gagaaaatag atgatttatg caggaattct tgccggtgga actggcacac
    27421 gcatgggaat cagtaacttg ccaaaacaat ttttagagct aggtgatcga cctattttga
    27481 ttcatacaat tgaaaaattt gtcttggagc caagtattga aaaaattgta gttggggttc
    27541 atggagactg ggtttctcat gcagaagatc ttgtagataa atatcttcct cttcacaagg
    27601 aacgtatcat cattacaaag ggtggtgctg accgcaatac aagtattgag aaaatcattg
    27661 aagccattga tgcttatcgt ccgcttactt cagaggatat cgttgttacc cacgattctg
    27721 ttcgtccatt tattacactt cgcatgattc aggacaatat ccaacttgcc caaaatcatg
    27781 acgcagtgga cacagtggta gaagcggttg atactatcgt tgaaagtacc aatggtcaat
    27841 ttattacaga tattccaaat cgtgctcacc tttatcaagg acaaacacct caaacattcc
    27901 gttgcaagga cttcatggac ctttatggat ctctttctga tgaagagaag gaaatcttga
    27961 cagatgcatg taaaatcttt gtgatcaaag gaaaagatgt ggccttggcc aaaggtgaat
    28021 actcaaatct gaagattaca accgtaacag atttgaagat tgcaaaaagt atgattgaga
    28081 aagactagta aaatgattaa tcaaatttat caactaacta agcctaagtt tatcaatgtc
    28141 aaatatcagg aagaggttat tgaccaagag aatcatatcc ttatccgtcc caactacatg
    28201 gctgtctgtc atgcggatca gcgttactat cagggaaaac gtgatcccaa gattttgaat
    28261 aaaaagcttc caatggcaat gattcacgag tcatgtggaa ccgtcatttc tgacccgacc
    28321 ggaacctacg aggttggtca aaaagttgtc atgattccca atcagtctcc tatgcagagt
    28381 gatgaagaat tctatgaaaa ctacatgaca gggacccatt tcttgtctag tggatttgat
    28441 ggctttatga gagagtttgt ttctctccct aaagatcgtg tggtggctta tgatgctatt
    28501 gaagatacgg ttgcagccat tacagagttt gtcagtgtgg gcatgcacgc tatgaatcgt
    28561 ctattgactc ttgctcatag caagcgggag cggatcgccg ttattggaga tggaagttta
    28621 gcttttgtgg ttgccaatat tatcaactat actttgccag aagcagagat tgtggttatt
    28681 ggtcgtcatt gggaaaagtt ggaactcttc tcatttgcca aagaatgcta tattacggat
    28741 aatattcctg aagatttggc ctttgaccat gcttttgaat gttgtggtgg tgatggtact
    28801 ggaccagcta ttaatgactt gattcgctac attcgtcctc agggaacgat tctcatgatg
    28861 ggagttagcg aatataaagt caatctcaat actcgcgatg ccttagaaaa gggcttgatt
    28921 ttggttgggt catctcgttc tggtcgcatt gattttgaaa atgctatcca aatgatggaa
    28981 gtcaagaaat ttgccaatcg tcttaaaaat atcctttatc tagaagaacc tgtaagagaa
    29041 attaaagata ttcatcgtgt ctttgcaacc gatttaaaca cagcctttaa aacagtgttt
    29101 aagtgggaag tataagtact ggaggttaat tgtggagaaa atcattaaag aaaaaatttc
    29161 ttccttactt agtcaagaag aggaagtcct cagtgttgaa caactgggtg gaatgaccaa
    29221 tcaaaactat ttggccaaaa caacaaataa gcaatacatt gttaaattct ttggtaaagg
    29281 gacagaaaag cttatcaatc gacaagatga aaagtacaat cttgaactac taaaggattt
    29341 aggcttagat gtaaaaaatt atctttttga tattgaagct ggtatcaaag taaatgagta
    29401 tatcgaattt gcgattacgc ttgattcaac gtcaatcaag accaagttcg acaaaattgc
    29461 tccaatatta caaactattc atacgtctgc taaggaatta agaggagaat ttgctccttt
    29521 tgaagaaatc aaaaaatacg aatccttgat tgaagaacaa attccttatg ccaactatga
    29581 atctgttaga aatgcagtct tctccttaga gaaaagactg gctgacttag gtgttgacag
    29641 aaaatcttgt catatcgatt tggtgcctga aaactttatc gaatcacctc aaggacgact
    29701 ttatttgatt gactgggaat attcatcaat gaatgatcca atgtgggatt tggctgccct
    29761 ctttttagag tctgaattca cttcccaaga ggaagaaact ttcttatctc actatgagag
    29821 tgaccaaaca ccggtttctc atgaaaagat tgctatttat aaaattttac aagatactat
    29881 ttggagtcta tggactgtct ataaggaaga gcaaggtgaa gattttggtg actatggtgt
    29941 gaatcgttac caaagagctg ttaaaggttt ggcttcttat ggaggttcag atgaaaagta
    30001 aaaacggagt tccttttggc cttctctcag gtattttctg gggcttgggt ctaacggtta
    30061 gtgcttatat cttttcgatt tttacagatt tgtcaccctt tgtggtggct gcagctcatg
    30121 attttttgag catctttatc ttactagctt ttctcttggt aaaagaaggg aaagttcgcc
    30181 tctcaatttt cttaaatatt cgcaatgtca gtgttatcat cggagccttg ctagcaggcc
    30241 ctatcggtat gcaggccaat ctttatgcag ttaagtatat cggaagttct ttagcttcat
    30301 ctgtatcggc tatttaccct gcgatttcag ttctattggc tttcttcttt ttgaagcaca
    30361 agatttcgaa aaatactgta tttgggattg tcttgattat tggagggatt attgctcaga
    30421 cctataaggt tgaacaggtt aattctttct acattgggat tctttgtgct ttggtttgtg
    30481 ctattgcatg gggaagtgag agtgttctta gctcttttgc catggaaagt gaattgagtg
    30541 aaatcgaagc cctcttaatc cgtcaagtaa cttcgttctt gtcctatctt gtgattgtgc
    30601 tcttctctca tcagtcattt actgcagtag ccaatggaca attgctaggt ctcatgattg
    30661 tttttgcagc ctttgatatg atttcctact tggcttatta tatcgctatc aatcgcttgc
    30721 aaccagccaa ggctacaggc ttgaacgtga gctatgtagt atggacggtc ttgtttgcag
    30781 ttgttttctt gggtgcaccg ctagatatgc tgaccattat gacgtcactt gtcgtcattg
    30841 ctggagttta tattattatt aaagaataaa ggagattcgt gtgaaagcca ttatcttagc
    30901 agcgggattg ggaactcgct tgcgtcctat gactgaaaat acccctaaag ccttggttca
    30961 ggttaatcaa aaacccttaa ttgagtacca aattgagttt ctcaaagaaa aaggaatcaa
    31021 tgacatcatc atcattgttg gttatcttaa agaacaattc gattacttaa aagaaaaata
    31081 cggtgttcgc ctcgttttca atgataaata cgctgactac aataactttt actctctcta
    31141 tcttgtaaaa gaagaattgg ccaacagcta tgttattgat gctgacaatt atctctttaa
    31201 aaatatgttc cgcaatgatt tgactcgttc gacttatttt agtgtttatc gtgaagattg
    31261 taccaacgaa tggttcttgg tctatggaga tgactacaag gttcaagaca ttattgttga
    31321 tagcaaggca ggtcgcatcc ttagtggtgt atccttctgg gatgctccaa ctgcagaaaa
    31381 gattgtcagc tttatcgata aggcttatgc aagtggcgaa tttgttgatc tctattggga
    31441 caatatggtt aaggataata tcaaagagct agatgtctat gttgaagaat tagaaggcaa
    31501 tagcatttat gagatcgata gtgtccaaga ctatcgtaaa ttagaagaaa tttttaaaaa
    31561 cgaaaattaa agattccaac atctgacaaa atagtcggat gttttttgat tttttacgaa
    31621 cttttacgaa tagatagatg agtagaaaaa gaaatggagt tatttatgaa aatcacaaac
    31681 tatgaaatct ataagttaaa aaaatcaagt ttgaccaatc aacagatttt gaaagttcta
    31741 gaatacggtg aaaatgttga tcaggagctt ttgttgggtg atattgcaga tatatcaggt
    31801 tgccgtaatc cagccgtttt tatggaacgt tattttcaga tagacgatgc gcatttgtcg
    31861 aaagagtttc aaaaatttcc atctttctct attttagatg actgttatcc ttgggatttg
    31921 agtgaaatat atgatgcgcc tgtactttta ttttacaagg gaaatcttga cctcctgaaa
    31981 ttcccgaagg tagcggtcgt gggcagtcgt gcttgtagca aacagggagc taagtcagtt
    32041 gaaaaagtca ttcaaggctt ggaaaatgaa ctggttattg tcagtggtct ggccaagggc
    32101 attgacacag cagctcatat ggcagctctt cagaatggcg gaaaaaccat tgcagtgatt
    32161 ggaacaggac tggatgtgtt ttatcctaaa gccaataaac gcttgcaaga ctacatcggc
    32221 aatgaccatc tggttctaag tgaatatgga cctggcgaac aacctctgaa atttcatttt
    32281 cctgcccgta atcgcatcat tgctggactt tgtcgtggtg tgattgtagc agaggctaag
    32341 atgcgttcag gtagtctcat tacgtgtgag cgagcaatgg aagaaggacg cgatgtcttt
    32401 gctattcctg atagcatttt agatggacta tcagacggtt gccatcattt gattcaagaa
    32461 ggagcaaaat tggtcaccag tgggcaagat gttcttgcgg aatttgaatt ttaaaaatga
    32521 cctaagctag aattctaaga aaaaatcaat tttaagagaa aatgaaccca acatttccat
    32581 aataaaacgc atattagcaa gtttttaaca cttgataata tgcgtttttt ctaagtggat
    32641 tagtagagta gaggattttt ctcatataat actcttcgaa aatctcttca aactacgtca
    32701 gcttccatct gcaacctcaa aacagtattt tgagctgact tcgtcagtct tatctacaac
    32761 ctcaaagcag tgctttgagc aacctgtggc tagcttccta gtttgcgctt tgattttcat
    32821 tgagtataag ggaaagtata gtgaattgaa ataagatgtg aacaactcta tcaggaaagt
    32881 caaattaatt tatagaaata ttttagcagc caaggtgcac tgttatagat tcaatacact
    32941 ataatttagt gtaattgaga aaggagaaat gattgtgatt gatgttggct aggttatgtt
    33001 caatgattcc taccgtctca aatcttgtca gtaaggaaaa ataaattctt caaaagtaga
    33061 gattacaagg cttgtttaag aaagaattca aagaccttga caaataaaaa taaaatggtt
    33121 attataagaa atggtctaaa atagatgatg atacttttcg aaaatctttt tacgtcagct
    33181 cagctttgcc ttgctgtgtt ttgagcaagc tacggttagc ttccgagttt gattttcatt
    33241 tactagaaat gaaactgatg agagatatca gtagacattt gagtcaggat attatggaaa
    33301 atgataaaaa gagctcgtga gattggcata tcagactact aaagtattga gtttgttagg
    33361 attttagcga ctagttagct gggaaaggaa gatatttgtg acaaataata aactgtattc
    33421 gttgatagaa tttagaaata aaatatatga agaattagaa ctttccagaa gtgatttagc
    33481 gattttacta tgtgccatgc ttatcgcctc tatcggatta aatatggatt cgactcccgt
    33541 gattattgga gccatgttaa tctctccttt gatgacacct attctgggag tggggctctc
    33601 tctagctata tttgatttta aattgttaag aaaatctttt aaaatattag ctattcaaat
    33661 tcttgccagt ctaatagctt caacacttta tttttatctt tctcccattt cgtatgctag
    33721 ttcggagatt gttgctagaa cctctccgac tatttgggat gttctcattg cttttgtagg
    33781 agggatagca ggtattattg gtgctaggaa aaaagagacc aataatattg ttcctggtgt
    33841 tgctattgca accgccttga tgcctcctct ttgtacagta ggttatgcta ttgcttctgc
    33901 taatctaaaa tttatcatag gctcctctta cctattcctc atcaattgta gctttattgt
    33961 cattgcgact tatataggtg ttaggttgat gatggttaag aaacattatt ttaaagataa
    34021 cgaagaagac tctaaaatgc gtaggatttt gcttctagtt gctgttttgc tgatgattcc
    34081 gagtttcatc tctgcaacga ctttagtgag agaaacgttg aaaaaagagt cccttaagaa
    34141 atttatatca gagcagtttc aggggtataa tattttgaaa aaaacctatt ctaaaaagac
    34201 tcatacccta aagctaacca tttcaggaaa ttatttgaca gaagaagaac tcgatatgat
    34261 ttcaagtaag agaggtgact atggtttaag tgatgtttct gttcaagttt cacaattgtc
    34321 tgattcagaa caacttagta aggaagagct ggtggagtat ttcttccagt atatcaagga
    34381 taaggaagca aaagaaaagg agaaagccaa taaatttgat acagagtctg aggagcaata
    34441 atttcttgag aatagctggt ttctctcgtg agtcttctat gtatatcaaa ggaagactga
    34501 ggttttaagt ataaaacttt tcttctatta tagtagctaa gtcttgacag ggttcaaaaa
    34561 atggtttaca ctttataaag tttattactt tgaaaaggtg tgatactgtg gctacggcaa
    34621 caaaaaagaa aaaatcaaca gttaaaaaaa atctagtcat cgtggagtcg cctgctaagg
    34681 ccaagacgat tgaaaaatat ctaggcagaa actacaaggt tttagccagt gtcgggcata
    34741 tccgtgattt gaagaaatcc agtatgtccg tcgatattga aaataattat gaaccgcaat
    34801 atatcaatat ccgaggaaaa ggccctctta tcaatgactt gaaaaaagaa gctaaaaaag
    34861 ctaataaagt ttttctcgcg agtgacccgg accgtgaagg agaagcgatt tcttggcatt
    34921 tggcccatat tctcaacttg gatgaaaatg atgccaaccg tgtggtcttc aatgaaatca
    34981 ccaaggatgc agtcaaaaat gcttttaaag aacctcgtaa gatcgatatg gacttggtcg
    35041 atgcccaaca agctcgtcgg atcttggatc gcttggtagg gtattcgatt tcgcctattt
    35101 tgtggaagaa ggtcaagaag ggcttgtcag caggtcgcgt tcagtccatt gcccttaaac
    35161 tcatcattga ccgtgaaaat gaaatcaatg ccttccagcc agaagaatac tggacagttg
    35221 atgctgtctt taaaaaggga accaaacaat ttcatgcttc cttctatgga gtagatggta
    35281 aaaagatgaa actgaccagc aataacgaag tcaaggaagt cttgtctcgt ctgacgagta
    35341 aagacttttc agtagatcag gtggataaga aagagcgtaa gcgcaatgct cctttaccct
    35401 ataccacttc atctatgcag atggatgctg ccaataaaat caatttccgt actcgaaaaa
    35461 ccatgatggt tgcccaacag ctctatgaag gaattaatat cggttctggt gttcaaggtt
    35521 tgattaccta tatgcgtacc gattcgactc gtatcagtcc tgtagcgcaa aatgaggcgg
    35581 caagcttcat tacggatcgt tttggtagca agtattctaa gcacggtagc aaggtcaaaa
    35641 acgcatcagg tgctcaggat gcccatgagg ctattcgtcc gtcgagtgtc tttaatacac
    35701 cagaaagcat cgctaagtat ctggacaagg atcagctcaa gctatatacc cttatctgga
    35761 atcgttttgt ggctagccag atgacagcgg ccgtttttga taccatggct gttaaattgt
    35821 ctcaaaatgg agttcaattt gctgccaatg gtagtcaggt taagtttgat ggttatcttg
    35881 ccatttataa tgattctgac aagaataaaa tgctaccaga tatggctgtt ggagatgtgg
    35941 tcaaacaggt taatagcaaa ccagagcaac atttcaccca accgcctgcc cgttattctg
    36001 aagcaacact gattaaaacc ttagaggaaa atggggttgg acgtccatca acctatgcgc
    36061 caaccattga aaccattcag aaacgttatt atgttcgcct ggcagccaaa cgttttgaac
    36121 cgacagagtt gggagaaatt gtcaataagc tcatcgttga atatttccca gatatcgtaa
    36181 acgtgacctt cacagctgaa atggaaggta aactggatga tgtcgaagtt ggaaaagagc
    36241 agtggcgacg ggtcattgat gccttttaca aaccattctc taaagaagtt gccaaggctg
    36301 aagaagaaat ggaaaaaatc cagattaagg atgaaccagc tggatttgac tgtgaagtgt
    36361 gtggcagtcc aatggtcatt aaacttggtc gttttggtaa attctacgct tgtagcaatt
    36421 tcccagattg ccgtcatacc caagcaatcg tgaaagagat tggtgttgag tgtccaagct
    36481 gtcatcaggg acaaattatt gagcgaaaaa ccaagcgtaa tcgccttttc tatggttgca
    36541 atcgctatcc agaatgtgaa tttacctctt gggacaagcc tgttggtcgt gactgtccaa
    36601 aatgtggcaa cttcctcatg gagaaaaaag tccgtggtgg tggcaagcag gttgtttgta
    36661 gcaaaggcga ctacgaggaa gaaaagatta aataagagga ggggcccgaa agtaaatttc
    36721 aggctccttt tggttagaac ttgacaaaat acatcatttt atgcgaaact agaagaagat
    36781 tattttaact aggagaagtt atgcgtctta tctatctgat aattggtttt ttatcactgg
    36841 ccttggctat tgttggggtt gttttaccct tgttgccgac aacgcctttc cttttgttgt
    36901 ctattgcttg tttctccaga agttccaagc gtttcgaaga ctggctttat cataccaagc
    36961 tctatcaaac atatgtagct gattttcgcg agactaagtc tattacgcgt gaacgaaaga
    37021 aaaaaatcat cgtctctatc tacgtcttga tgggaatttc tatttatttt gcacctcttt
    37081 taccagtcaa aatcggtctg ggtgctttga ccatctttat cacttattat cttttcaagg
    37141 tcattccaga caaagaatag ttaaaacagt agttatttgc cttgataaaa ttgaaagcat
    37201 attcataata atatgatata ataaatttga agtaatattc aaggagaatc aaatgattta
    37261 cgaattttgt gctgaaaatg tgactttact tgaaaaagcg atgcaggctg gagctcgtcg
    37321 gattgaactc tgtgataatc tagcagttgg tgggacaaca cccagctatg gagtgactaa
    37381 ggcagcggtt gaactggcag ctaactacga tacaaccatc atgaccatga ttcggccacg
    37441 tggtggtgac tttgtctata atgacctaga aattgctatc atgctagaag acattcgttt
    37501 gactgctcag gctggaagtc aaggggttgt atttggaact ttaactgctg ataaaaagtt
    37561 ggataagcct aatctggaaa agttaattgc tgcatcaaaa ggaatggaaa ttgtctttca
    37621 catggccttt gatgaactaa gtgatgaaga tcaaccggaa gctattgact ggctcagtca
    37681 agccggtgtc actcgtatcc taactcgtgc tggtgtgtct ggcgactcct tagaaaaacg
    37741 ttttgttcac tatcacagaa ttttggagta cgctaaaggt aaaattgaaa ttctaccagg
    37801 tggggggatt gaccttgaaa accgtcaaac ctttatcgac caggtggggg taacacaatt
    37861 gcatggtact aaggttgttt tttaaaaaat agaaaggaac tgctagcttt gggtagcagt
    37921 tttcacttat gtttgaaatt tttaaatcct atcaatttaa tcaagaaaag gctcatgatt
    37981 atggttttat agaaaatagc gaagtctgga catatagttg ccagattttg caaggtgact
    38041 ttgtcatgac tgtgtccatc actgctgata atgtgaactt tcaagtcttt gaccaagaga
    38101 ctggtgacct ctatcctcac gttcatatgg aaagcatgag gggaagtttt gtcggaaatg
    38161 tccgtgaggc ttgtctggag attctttacc agattcggaa ggcttgtttt gatgtgcaag
    38221 attttatctg tcatcagact aagcgtatca tgactcaagt tcaggaaaag tatggaaacc
    38281 agttggagta tctgtgggaa aaatcgcctg atacagctgt attgcgccat gaaggcaatc
    38341 aaaagtggta tgccgtcttg atgaaaatct cttggaataa gctggaaaag ggcagagaag
    38401 gacaagtgga agcagtcaac ctcaagcatg accaagtagc taatttgctt tcacaaaagg
    38461 ggatttatcc agccttccat atgagcaagc gctactggat tagtgtgtcc cttgatgata
    38521 ctttatcaga tgaagaagta ctggaattga tagaaaaaag ttggaactta acctctaaaa
    38581 aatgaaatat tttaataatt ttcatgaact ttcaattagc taaatattct ttactgaaga
    38641 aattttcaga aaatatagga tttaccacac cagaggaata tggtgccatc ttcaaatacc
    38701 tgattgagaa tgtcaagacg gatcgtcaga tcatctattc gcctcactgt catgatgacc
    38761 tcggaatagc agtggcaaat agccttgctg ctgtcaagaa tggtgcagga cgtgttgaag
    38821 agactatcaa tggtattagg gagcgagctg gaaatgctgc tttggaagaa attgcagtgg
    38881 ctctcaatat tcgccaagat tactaccaag tagaaaccag tattgtccta actgagacca
    38941 tcaatacgtc agaaatggtt tctcgcttct ctggtattcc agttcctaaa aacaaagccg
    39001 tcgttggtgg caataccttc tcccacgaat ctggtattca ccaagatgga gtccttaaaa
    39061 atcctctcac ttatgagatc atcacacctg aattggttgg tgttaagatt ccgcttggaa
    39121 aattatctgg tcgccatgct tttgttgaga aactgagaga attggcccta gattttacag
    39181 aagaggatat caaaccactc tttgctaagt tcaaggcact ggtcgataag aagcaagaaa
    39241 tcacagatgc agatattcga gctttggtag ctggaaccat ggttgaaaat ccagaaggct
    39301 tccactttga tgatttacaa cttcaaactc atgcagataa tgacattgaa gcgctcgtta
    39361 gcctagccaa tatggatggt gagaaagtcg aatttaatgc gacagggcaa ggttccgttg
    39421 aagcaatctt taatgctatc gataagttct ttaaccaatc tgttcgtttg gtgtcctaca
    39481 ctatcgatgc ggtaacagat ggaatcgata cccaggaacg ggttttggtc actgttgaaa
    39541 acagagatac agaaaccatc ttgaatgcag cagggcttga ttttgatgtg ttgaaggctt
    39601 ctgctattgc ctatataaac gctaatacct ttgttcaaaa agagaatgca ggtgagatgg
    39661 gacgcagtgt ttcttaccac gatatgccta gtgtgtaaag gagaaggcta tggcaaagaa
    39721 aatagtagct ctagcaggag acggaattgg cccagaaatc atggaggctg gtttagaagt
    39781 tctggaggct ctagctgaaa aaacaggttt tgactatgag attgacagac gaccgttcgg
    39841 aggtgcagat attgatgcag caggatctcc cttacctgat gaaaccctta aggcaagtag
    39901 ggaagcagat gctatcctac tagtagctat cggtagtcct cagtatgatg gagtagcggt
    39961 tcgccctgaa caaggcctga tggctctccg taaggaactc aatctttacg ctaatattcg
    40021 tcctgtaaaa atctttgaca gtctcaagta tttgtcacca ctcaaaccgg aacgaatttc
    40081 tggtgtagac tttgtcgtgg tgcgtgaatt gacaggcgag atttactttg gagatcatat
    40141 tcttgaagag cgcaaagcgc gtgatatcaa cgactatagc tatgaggaag tggagcggat
    40201 tattcgcaaa gcctttgaaa ttgcaagaaa tcgcagaaaa atcgttacta gtatcgataa
    40261 gcaaaatgtt ctagcgacct caaaactctg gcggaaagta gctgaggaag tcgcacagga
    40321 tttcccagat gtaaccttgg aacaccagct ggtagactca gctgctatgc ttatgattac
    40381 caatcctgct aagtttgatg ttattgtaac ggagaatctt tttggagata ttttatctga
    40441 tgaatcaagc gtcttatctg gtacacttga ggttatgcca tcagccagtc attctgaaaa
    40501 tggaccaagt ctctatgaac ctattcacgg ttcagcacct gatattgcag gtcaaggaat
    40561 tgccaatcct atttccatga ttttattagt tgtcatgatg ttgagagata gtttcggacg
    40621 ttatgaggat acagagcgta tcaaacgtgc tgttgagaca agtctggcgg caggaatttt
    40681 aacgagagat ataggaggtc aggcttcaac aaaggaaatg atggaagcta ttattgcaag
    40741 gttatgaagt tagacgaaaa aattactcta gtccttttga tttggaatgt catcattttc
    40801 ttgatttatg gcattgacaa attcaaggca agaagaagag cttggcgcat cccagagaaa
    40861 atcttactca ttttagccct tacttgtggt ggttttgggg cctggttagc tggaatcact
    40921 tttcaccaca agactcgaaa atggtacttt aaaacagttt ggtttcttgg gatggtgacc
    40981 acactagtag ccttatattt tatttggagg taatggatgg tagggtcttc gagggaacac
    41041 gctgcttggg ctctagcgga ctatggtttt aaggtcgtga ttgcaggatc tttcggtgac
    41101 attcattaca ataatgaact caataatggc atgttgccaa tcgttcagcc tagagaggtt
    41161 agagagaaac tagcccagct aaaaccaacc gaccaggtaa ctgtggactt ggaacaacaa
    41221 aaaatcatct caccagttga agaattcacc ttcgagatag atagcaagtg gaaacataaa
    41281 ctcctaaata gtttggatga tatcggtatt accttgcagt atgaagagtt gattgctgct
    41341 tatgaaaaac aacgaccagc ctactggcag gattagaaaa aatagaaaag gaaatatagt
    41401 aaactgaaat aagatgtaaa caaatgaatt ggagcttaac atccatttcc agcaattttt
    41461 tagaaactac agtggactat tctggattca acacattata aaattatgac aaaacacatt
    41521 cacaagaagg ctacgacatt ttaaaaggtg agggcggatg tatcgtttgc cctactaaag
    41581 ttggttacat tatcatgacc agcaacaagg caggacttga gcgtaagttc gcagccaaag
    41641 aacgtaagcg taacaaacca ggtgttgttc tctgcggtag catggatgaa cttcgcgctt
    41701 tagcgcaact caacccagaa attgaagcat tctactaaaa acattggatg aagatattct
    41761 tcttggttgt atccttcctt ggaaaccaga agcctttgaa aaactcaaag catacgggga
    41821 tggccgtgaa gaacttatga ctgatgtacg tggtactagc tgttttgtta tcaagtttgg
    41881 aaaagcaggt gaacaattgg ctgccaagct ttgggaagaa ggtaaaatgg tctacgcctc
    41941 atatgcttca atgacaaaac gattgaaact cgctatgaga gcaaggtgta atggtgtcta
    42001 tggtcgataa ggacggcaaa ctcatcccag aacaaggagg agcacgttca acttcaccag
    42061 caccagttgt gatccgtaaa gggcttgaca ttgataaaat catgatgcac ctgtcagata
    42121 cttttaactc atgggactac tgtcaggttg agtattatta agataaaaaa agaagtctag
    42181 tgttatgaga tattaaagct cctaacactg gactttttgt ttagaatttc ttttcttttt
    42241 ctataggata tggtattcta tgtagaaaat atatgttaat aagtaatgcc aatatttaaa
    42301 catcattagt aaaaggagtt agattgatga ataaaagaaa agttagttta gaagattttt
    42361 ataaatggta tagtctaaat aaagaagagt tattaaataa ggcaactgtt ggtgaaaagt
    42421 ttaatgataa attaaaagaa gagtttctcc aggaatggcc tttggatagg attttaacaa
    42481 tgtcaatcga tgaatatgta ataggaaagg gacagcaaaa taagtcttta tgctacgctc
    42541 ttgagaaggg aaaatacaaa aatctatttc ttggaatttc tggtggctca gcttcaaaat
    42601 ttggtattta ttggaataaa aaaacaaaca aatataaaga tcaagctaat aatgagattt
    42661 cagagttgga tcagcgattt tcaaaattaa aatcagattt gtatgaaatt atcaaagaag
    42721 gtattcgttt taactttgaa aatcctattt ttgatatgaa aagatcaaca aatgaattta
    42781 ttggtcgttc tgctatggtg acaaaattac tttgtatcta tactgaggga gatcctttct
    42841 ttggtgtaaa tattaatagt cagaaagaat tttggaacca ctttgtttct cagacaaatc
    42901 aaggtggacc ttatctgcaa aatcataaaa taattgaact ggtgtccaaa acttatcctg
    42961 agttggagcc atcgaaatta ggaactatgc tttttgagta ttctaagctt tttatggaaa
    43021 ataaggaaga caatagtaca atggattcat caaacaattt tagtcatcaa ttaactcaat
    43081 ctctattaaa gtctccaaac cttatccttc gtggtgctcc tggcacagga aagacttatc
    43141 ttgctaaaga aattgccaaa gaattaacgg atggcaacga agaccaaatc ggatttgtac
    43201 aatttcaccc atcctatgat tatacggatt ttgtagaagg tttaagacca gtatcaaatg
    43261 gggatggagc tattgagttt aggctacagg acggtatttt taaagatttt tgtcagaaag
    43321 caaaagaaac ccaattgatt ggaggacaag ataattttga tgaggcttgg gattcttact
    43381 tagaatatat aaatgttgct gaagaaaaag aatatataac aaaaacatct tacttatctg
    43441 ttaatagtag acaaaatttg tcagtaaatt atgatagtgg tgttccagga tggtcactac
    43501 ctagcaaata tgtttacgag ttgtataaag ataaaaatta taataagcaa gaatactaca
    43561 aaagtggtgg aaaaactgtc ctagaaacat tgagaaagag atttggtttg aaagactatg
    43621 tttccccaac agaaattgat actgataaga aattcgtctt catcatcgat gaaatcaatc
    43681 gtggggagat ttctaagatt tttggcgaac tctttttctc tatcgaccct ggctatcgtg
    43741 gtgaaaaagg aagtgtttct acccaatatg caaatctaca cgaaactgat gaaaagttct
    43801 atatccccga aaatgtttac atcatcggaa ctatgaatga tattgatcgt tcagtggata
    43861 cctttgattt tgctatgcgt cgtcgttttc gttttgttga agttactgcc gagggtcaag
    43921 ttggcatgtt ggataaagag ctgaatatcc atgcagaaga agcaaaaatt cgtctaagaa
    43981 acttgaacgc tgctatcgaa aatgttcagg aattaaacag tcattatcat attggaccaa
    44041 gttattttct taagttgaag gatgtagatt ttgactatga attactctgg tctgattata
    44101 ttaagcctct cctagaagac tacttgcgag gttcttatga tgaggttgaa actttggaaa
    44161 ctttgaaaaa agcatttgaa ctgacaaata atgagcaaaa agatcaggca gtagctgatg
    44221 acaatgaagg cgatgaaaac gatgatgcgg attactgata atcaacacaa gattattaaa
    44281 gaaaaatttg ttgaagaata tcctaaacta agcaatcttc ttttagacag aaccttggaa
    44341 agtctatccc aagatgaacg tattttcatt tttccaaatg atttgactca tactcctgat
    44401 ttggataagg accaaaagat ttttgaaaca gtcaatcaga aaatcaagac agggaacgtg
    44461 attggttttc ttggatatgg tcaggaaaga ttaacgattt cctcacgatt ttctgatgag
    44521 agtaatgacc attttttgca ttatctctta aacaaggttc ttcatatcaa tctcactagt
    44581 ttagatgttg ctttgtctcg tgaagagagg ctttatcaac ttttgatgta tctcttcccc
    44641 aagtatctac aagctgctat tcgaaaaggt ctttataagg aataccagag attttctcat
    44701 aacgacagtc atgttaaggg agtgattgat gtaagaaacc atctcaagaa aaatcttcct
    44761 ttcacgggaa atattgccta cgcaacgaga gagttcacct atgataatcc cctcatgcag
    44821 ttggtccgtc acactattga atacattaag aatcagaaaa gcattggtca aggggtacta
    44881 gataatctct caactagtcg tgaaaacgta tctgaaatcg tgcgtgtaac gccctcttat
    44941 aaactagctg atcgtgctaa gattattcgg ggaaatcaat ctaaacctat acgtcatgca
    45001 tactttcacg agtacagaaa cttacaagaa ctttgtctga tgatcctaaa ccaagaaaag
    45061 cacggtttag ggtatcaaga tcaaaaaatc tatggtattc tctttgatgt tgcctggctt
    45121 tgggaagagt atgtttacac cttgttgcca aaaggttttg tacatcccag aaataaggat
    45181 aagacggatg gaatttcagt attttctgtt gggaaacgaa aagtatatcc agatttttat
    45241 gacagagaac gaaagattgt tctagatgca aaatataaaa aactggaatt gactgaaaaa
    45301 ggaatcaacc gtgaggactt attccagctg atttcctatt cttatatttt aaaagctgag
    45361 aaggctggac tgatttttcc tagtatggag cagtcagtaa atagtgaaat aggaaaagta
    45421 gctggctatg gagctcaatt gaagaagtgg tctattcgaa tccctcagaa tgcctcattc
    45481 tatagtacat tttgtaaaat gatggaaaat tcagaagaaa attttaaagc gattattgat
    45541 gaagaagtgg ggagaaaata atttcccctc tttcttttat ttttaacaca agtaaaaccc
    45601 gaacgatata ttttaattca taaaataatt tgacaaaaac tgtactttga tttataataa
    45661 attaaggaaa cgtcggaaaa ggcgtagtga tgcaagagca taggtaggtc attacaaaag
    45721 aaacgagaca tcgatatgtt aaatgaattt ccaatttttg attacgaaga tattcaattg
    45781 attccaaata aatgtgtcat taaaagccgt gcagaagcgg atacaagtgt cactttagga
    45841 aatcacacct ttaaactacc tgttgtgcca gcgaatatgc agacgatttt ggatgaaaat
    45901 gtagcagagc aactggctaa aggtggttac ttctacatta tgcaccgttt tgatgaggca
    45961 ggacgcattc cttttattaa acgaatgcac aatcaagggc tcattgcttc tatctctgtc
    46021 ggtgttaagg attatgagta tgattttgtt agccagctca aggctgatac tcctgagtat
    46081 atcactattg atattgctca tggtcatgcg gatagcgtga tttctatgat tcaacacatc
    46141 aagaaagaat tgccagatac ctttgtcatt gctggaaatg tgggaacacc agaagctgtg
    46201 cgtgaattgg aaaatgctgg tgcggatgct actaaggtcg gaatcggtcc tggtaaggtt
    46261 tgtatcacca aggttaagac tggttttggt acaggtggtt ggcagttggc tgctctacgc
    46321 tggtgtgcca aggctgcgcg taaaccgatt atcgctgatg gaggaattcg tactcacggt
    46381 gatattgcca agtctatccg cttcggtgct agcatgatca tgattggttc cctctttgca
    46441 ggacacattg aaagtccagg gaaaacgatt gaagtcgatg gtgaacagtt caaagaatat
    46501 tatggttcag cctcacaata tcaaaaaggt gcttacaaaa atgtggaagg caaacgtatc
    46561 ttgcttcctg ctaaaggtca tctgcaagac actttaactg agatggaaca agaccttcaa
    46621 agtgctattt cttatgcagg tggacgtcag gttgctgacc ttaaacacgt tgattatgtg
    46681 atcgtgaaaa actccatctg gaatggggat gcttcccact aagacggggt ctttgaccaa
    46741 aaaacttgtt attagagcaa atttctgtta taataaaaca agtttccacc cttagtgtaa
    46801 tggatatcac gtaagattcc ggttcttgag atgggggttc gattccctca gggtggatgt
    46861 aaacatccta aaaagccttt aatagggctt ttttctttat cctgacccaa atttgccgct
    46921 aaaactgaga atctctgtct aaagaattcc caaatgcttt ccagtcccgt tttagagtga
    46981 ctcagggggc tttttttgat ataataaaaa ggactattat cagttagaaa gaggttggta
    47041 tgaaagaatt acaaactgta ctaaagaatc attttgcaat cgaatttgca gacaaaaatt
    47101 tactggaaac tgcctttact catacgagtt atgccaatga gcaccgcctc ttaaaaattt
    47161 cacacaatga acgcttggaa tttttaggag acgctgttct acagttattg atttcagaat
    47221 atctatataa aaaatatcct aaaaagcctg aaggtgacct atcaaaactc cgtgctatga
    47281 ttgtccgtga ggagagttta gctggttttg cgcgtgattg ccagtttgac cagtttatca
    47341 agttgggtaa aggggaagaa aaatctggtg gtcgcaatcg tgacaccatt cttggtgatg
    47401 cctttgaagc ctttcttggt gcccttcttt tggataagga tgtggccaag gtcaaggaat
    47461 ttatctatca agtcatgatt cctaaggttg aagcaggcga atttgagatg attacagact
    47521 ataaaaccca tctccaagag ttacttcagg tcaatggtga tgtggctatt cgttatcagg
    47581 tgatttctga aacagggcct gctcacgata aggtctttga tgtagaagtt cttgttgaag
    47641 gtaagagcat cggtcaaggc caaggtcgtt ctaagaaatt agcagagcag gaagctgcca
    47701 aaaatgccgt tgagaagggg ctggattcat gtatttaaag gaaatcgaaa ttcaggggtt
    47761 caagtctttt gctgataaga ccaaggtcgt ttttgaccaa ggtgtgacgg cagttgttgg
    47821 acccaatgga tctggaaagt ccaatattac agaaagtctg cgttgggctt tgggggagtc
    47881 tagtgtcaag agtctccgtg ggggcaagat gccggatgtc atctttgctg gaaccgaaag
    47941 tcgcaaaccg ctcaattatg cttctgtagt tgtgactctg gataatcatg acggatttat
    48001 caaggatgca ggtcaagaaa tcagggtgga acgccatatc tatcgtagtg gagatagcga
    48061 atacaagatt gacggcaaga aagtccgtct gcgtgatatt catgacctct tcttggatac
    48121 tggattggga cgagattcct tctctattat ttcccaaggg aaggttgagg agatttttaa
    48181 ttccaagcct gaggaacgac gagctatttt tgaagaagct gcaggagttt taaaatacaa
    48241 gactcgcaga aaagaaactg agagtaaact gcaacaaact caggataatc tagaccgctt
    48301 agaggacatt atctacgagt tggataatca aatcaagcct cttgagaagc aagctgagaa
    48361 tgcctgtaag tttttagact tggaaggaca acgtaaggct atttatttag acgttctggt
    48421 tgctcaaatc aaggaaaata aggcagaact agagtcgaca gaagaagagc tggctcaggt
    48481 tcaagaactc ttgatgagtt attaccaaaa gcgtgaaaaa ttagaagaag aaaatcaaac
    48541 tcttaaaaag caacgccaag atttacaggc tgaaatggcc aaagaccaag gcagtttgat
    48601 ggacttgact agtctgatta gtgatttaga aagaaaatta gccctatcga aactggagtc
    48661 cgagcaagtg gccttgaatc aacaggaggc acaagctcgt ttggctgctt tggaggataa
    48721 gagaaattca ctcagcaaag aaaagtctga taaagaaagc tctttagctc tgttagaggg
    48781 aaatctagtc caaaataatc aaaaactcaa tcgtttagaa gctgaattgc tggctttctc
    48841 agacgatcct gatcagatga ttgagctctt acgtgaacgc tttgtagctc ttttacaaga
    48901 agaagcggat gtctcaaacc agttgacccg tattgagaat gagttggaaa atagtcgtca
    48961 gctttctcaa aaacaagcag atcaactaga aaagctgaaa gagcaattag ctatagctaa
    49021 agagaaggct agtcagcaaa aggaagagct tgaaactgcc aaggagcagg ttcagaaatt
    49081 attggctgac taccaagcta ttgccaagga gcaagaggag cagaaaactt cctatcaagc
    49141 tcaacaaagc caactctttg accgtctgga taatctcaaa aacaagcagg ccagagctca
    49201 aagtttggaa aatatcctga gaaatcatag taacttttat gcaggtgtta agagtgttct
    49261 ccaagaaaaa gatcgcctag gtgggattat tggtgcagtc agtgagcatc tgacctttga
    49321 tatgcattat caaactgccc tagaaattgc gcttggagcg agtagtcagc acattattgt
    49381 agaagatgag aatgcggcaa ccaaggctat tgacttcctt aaacggaaca gagccggtcg
    49441 tgcaaccttt cttcctttga ccactattaa ggcgcgtacg atttctagtc agaaccaaga
    49501 tgctatcgct gtaagcccag gtttccttgg gatggcagat gagttggtga cttttgatac
    49561 tagactggaa gccattttca agaacttgct agctacgacg gctatctttg ataccgtaga
    49621 acatgcgcgt gaagctgctc gacaagttcg ttatcaggtt cgtatggtga cattggatgg
    49681 gacagaatta cgcacgggtg gttcctatgc gggtggtgcc aatcgccaaa ataacagtat
    49741 tgtcatcaag ccagaactgg agcaattaca aaaagaaatt gctgcagatg aagcaagctt
    49801 gggttcagaa gaagcggctt tgaagacctt gcaagaccag atggctgcat tgacagaaag
    49861 attagaagcc atcaaatctc aaggagagca ggcacgtatt caggagcaag gcttgtccct
    49921 cgcttatcag caaactagtc agcaagttga agaactggaa actctttgga aactccaaga
    49981 agaggaaata gatcgtcttt ctgagggaga ttggcaagcg gataaggaaa aatgtcaaga
    50041 gagccttgct actatcgcca gtgaaaagca aaatctggaa gctgagattg aagaaattaa
    50101 gtctaataaa aacgccatcc aagaacgcta tcaaaatttg caggaagagg tggcgcaagc
    50161 tcgcttgctt aagacagaac tgcaagggca aaaacgttat gaagtagctg atattgagcg
    50221 tttaggcaag gaattggaca atcttaatat cgaacaagaa gaaattcagc gcatgctcca
    50281 agaaaaagtt gacaatcttg agaaggttga tacagaattg ctcagtcaac aggcggaaga
    50341 atccaaaact cagaaaacaa atctccaaca aggtttgatt cgcaagcagt ttgagttgga
    50401 tgatatagaa ggtcaactgg atgatattgc cagtcacttg gatcaagctc gccagcagaa
    50461 tgaggagtgg attcgcaagc aaacacgtgc tgaagccaag aaagaaaagg tcagcgagcg
    50521 cttgcgccat ctacaaaatc aattaacaga ccagtaccag attagctata ctgaagcact
    50581 agaaaaggca catgaattgg aaaacctcaa tctggcagag caagaggtgc aggatttaga
    50641 gaaggctatt cgctcattgg gacctgtcaa cttggaagct attgaccagt acgaagaagt
    50701 tcacaaccgt ctggactttc taaatagtca gcgagatgat attttgtcag cgaaaaatct
    50761 gctccttgaa accattacag agatgaatga tgaggtcaag gaacgcttta aatcaacctt
    50821 tgaagctatt cgtgagtcct ttaaagtgac cttcaagcag atgtttggcg gaggtcaggc
    50881 agacttgata ttgactgagg gcgacctttt aacagctggt gtggagattt ctgttcaacc
    50941 tccaggtaag aaaatccagt cgcttaacct catgagtggt ggtgaaaaag ctctatcggc
    51001 tcttgccttg cttttctcca ttattcgtgt caagaccatt ccttttgtca tcttggatga
    51061 ggtggaagct gcgctggatg aagccaatgt taaacgtttt ggggattacc tcaaccgctt
    51121 tgacaaggac agccagttta tcgttgtaac ccaccgtaag ggaaccatgg cagcggctga
    51181 ttccatctat ggagtgacca tgcaagaatc gggtgtttca aagattgttt cagttaagtt
    51241 aaaagattta gaaagtattg aaggatgaca attaaactag tagcaacgga tatggacgga
    51301 accttcctag atgggaatgg acgctttgat atggatcgtc tcaagtctct cttggcttcc
    51361 tacaaggaaa aagggattta ctttgcggtg gcttcgggtc ggggatttct gtctctggaa
    51421 aaattatttg ctgatgttcg tgatgacatt attttcatcg cggaaaatgg cagtttggta
    51481 gagtatcaag gtcaggactt gtatgaagcg actatgtctc gtgactttta tctggcaact
    51541 tttgaaaagc tgaaaacgtc accttatgta gatatcaata aactgctctt gacgggtaag
    51601 aagggttcat atgttctaga tacggttgat gagacctatt tgaaagtgag tcagcattat
    51661 aatgaaaata tccaaaaagt agcgagtttg gaagatatca cagatgacat tttcaaattt
    51721 acaaccaact tcacagaaga aacgctagaa gctggtgaag cttgggttaa tgaacatgtc
    51781 cctggtgtta aggccatgac aactggcttt gaatctattg atattgttct ggactatgtc
    51841 gataagggtg tagctattgt tgaattagct aaaaaacttg gtatcacaat ggatcaggtc
    51901 atggcttttg gagacaatct taatgactta catatgatgc aggttgtggg acatcctgta
    51961 gctcctgaaa atgcacgacc tgaaatttta gaattagcaa agactgtgat tggtcaccat
    52021 aaggaacggt cggttatagc ttatatggag ggcttataat ggcagatata aaattgattg
    52081 cattggactt ggacgggacc ttgctgacta ctgataaaag gctgacggat cgtaccaagg
    52141 aaaccttgaa agctgcgcgt gatcgtggta tcaaggtcgt attgacaact ggtcgtccct
    52201 taaaagccat ggacttcttt ctccatgagt tagggactga cggccatgaa gatgagtata
    52261 ccattacttt taatggtgga ttagttcaga aaaatacagg agaaatcctt gataaaacag
    52321 tcttttcata tgatgatgtg gcacgtttgt atgaagaaac agagaaatta tcactgcctc
    52381 ttgatgccat ctcagaagga acagtttatc aaatccaatc ggaccaagaa agtctttatg
    52441 ccaaattcaa tccagctttg acctttgttc cagtggactt tgaagactta tctagtcaaa
    52501 tgacctacaa caaatgcgtg actgcctttg ctcaagaacc cttggatgca gccattcaga
    52561 agatttctcc agaattgttt gaccaatatg aaatctttaa atcacgtgaa atgttgctag
    52621 aatggtcacc aaagaatgtt cataaagcaa caggtttggc aaaactaatc agccatcttg
    52681 gaatcgacca aagtcaagtg atggcttgtg gtgacgaggc caatgacctc tctatgattg
    52741 aatgggcagg tcttggtgtt gctatgcaaa acgctgtttc tgaagtaaag gcagccgcaa
    52801 atgtagtgac gccgatgacc aacgatgagg aagctgtcgc ctgggctatc gaagaatatg
    52861 tgctaaagga gaactaagat atgggattgt ttgaccgtct attcggaaaa aaagaagaac
    52921 ctaaaatcga agaagttgta aaagaagctc tggaaaatct tgatttgtct gaagatgttg
    52981 atcctacctt cacagaagtt gaggaagttt ctcaggaaga agcagaggtt gaaattgttg
    53041 aacaagctgt gttccaagaa gaggaaatcc aagacacagt tgaagaaagt ctggatttag
    53101 agccagttgt agaagtttct caaaaagaag tcgaagaatt tccacactca gaagaaggga
    53161 atactgagtt tctagagact atagaagaaa ataattctga agttcttgaa gcagaaaggc
    53221 ctcaagcaga agaaaccgtt caggaaaaat atgaccgcag tcttaagaaa actcgtacag
    53281 gtttcggtgc ccgcttgaat gccttctttg ctaacttccg ctctgttgac gaagaatttt
    53341 tcgaggaact ggaagaactg ctgattatga gtgatgttgg tgtccaagtc gcttctaact
    53401 taacggagga actacgttac gaagccaagc ttgaaaatgc caagaaacct gatgcacttc
    53461 gtcgtgtcat cattgagaaa ttggttgagc tttatgaaaa ggatggtagc tacgatgaaa
    53521 gcatccactt ccaagataac ttgacagtta tgctctttgt tggtgtgaat ggtgttggga
    53581 aaacaacttc tatcggaaaa ctagcccacc gctacaaacg agctggtaag aaggtcatgc
    53641 tggttgcagc agataccttc cgtgcgggtg cagtagctca gctagctgaa tggggccgac
    53701 gagtagatgt tccagtagta actggacctg aaaaagctga tccagccagc gtggtctttg
    53761 atggtatgga acgtgccgtg gctgaaggta tcgatattct catgattgat actgctggtc
    53821 gtctgcaaaa taaggataac cttatggctg agttggaaaa gattggtcgt attatcaaac
    53881 gtgttgtgcc agaagcacca catgaaacct tcttggcact tgatgcatca acaggtcaaa
    53941 atgccctagt acaggccaaa gaattttcga aaatcacacc tttaacggga attgttttga
    54001 ctaagattga tggaactgct cgaggaggtg tggttctagc cattcgtgaa gaactcaata
    54061 ttcctgtaaa attgattggt tttggtgaaa aaatcgatga tattggagag tttaactcag
    54121 aaaactttat gaaaggtctc ttggaaggct taatctaatc agaagcaaaa atcctgcaag
    54181 gtacaaactt gcaggatttt tttattcgaa acgaccatct tgacgatagg cgatatctgg
    54241 ttgccaagtc catttggcat cgaatttttc aagtaggtca aagctggctt gaggtcccat
    54301 gcttccagct ttatagtcat gaagtggggc accattttcg gcccagagct cttcaatacg
    54361 gtcaatcaac ttccatgacg caccaacttc atcccagtgg ctaaagttag ttgagttgtt
    54421 atttaggaca tcataaatca atttttcgta tggttctgga gaagcaccag ttgcagtcgc
    54481 atctgtacgg taatcaagtg agttaggagc caagttaaat tcttctccta cttgcttccc
    54541 atttaggcta agagagaagc cttctgttgg ttgaatatag atggtcaaaa tatttggagc
    54601 aagtggttct ccaaagatag aatccatttg tttaaagacg atgttgacat gggttccttt
    54661 ttcagtcagt cgtttacctg tacggaaaaa gaaaggaaca ccacggaatc gatcgctgtc
    54721 tacaaagaag gcacctgatg taaaggtttc agttgttgat tctggattca catttggctc
    54781 gctacgataa gagatgtatt tcatgccatc aatcttacca gagcggtatt gcccacggat
    54841 aaagtgttct ttgagttctt catcagttgg atgatagagg tttttaaaga ccttaatctt
    54901 ttcagcacga atctcgtctt ttgtgaagct tgctggtttg tccatggcga ggagcgaaag
    54961 aagttgtaga gtgtggtttt ggaccatgtc acggagggca ccggattggt catagtagcc
    55021 accacgttct tctacaccca agcgctccgc aaaggtaatt tgaacattgt cgataaaatc
    55081 cttgttccaa acgttttcaa aaatcaagtt tgcaaagcga actgcaaaga tgctttggat
    55141 catttcctta ccaagataat ggtcgatacg gaaaatttgt tcttcgtcaa atgttgctag
    55201 gagttcgtca ttcaacttgt ttgcagttgc gtaatctgta ccaaatggtt tttcaacgat
    55261 caagcgctca aaacctttgc catcgacaat gttttcagat ttgaggtgtt tggcaatggt
    55321 tccaaagaac tgaggtgcca tagacaagaa gaagagctta ttgtgttcag cttggtattt
    55381 ttcattaagc tcagcttgta attgacgcaa agcaatataa tgttccgaat cattgacatc
    55441 atggctttga tagtagaagt ggctagcaaa ttcttgggct tgctcggtac tatctgccaa
    55501 atcaaggatg gactcgacaa ctacagattc aaaatattcc ttactccaag gtctacgggc
    55561 agttccaata acggcaaagt gcttggaaag attgccggat ttatatagtc taaaaaggga
    55621 agggtagagc ttgcgtttag ccaggtctcc actcgcaccg aaaattgtaa caataacctt
    55681 agatgacatc tagctaccta atttctattt ttattcctag tcttgctagg tatgaggaaa
    55741 cctcatttca taaacttaat tctaacataa ttttccgaaa aatcaaaaat tccaatacga
    55801 ggtagaaaaa ctgcaaggaa atccttacag tttgagttta gacgtttaag accttatcta
    55861 agaactcttt cagacgaggg tgttgtgggt tatcaaagat ttggtcaggt gttccgtctt
    55921 caaggaactc gccatctgca gtaaagataa cgcggttggc aacctgacga gcaaatccca
    55981 tctcatgggt tacgataatc atggtcatgc cttgctcagc caattccttc ataacgttaa
    56041 gtacgtctcc aaccatctca gggtcaaggg cagaagttgg ttcatcgaag agcatgatgt
    56101 ctggattcat tgctaggcca cgagcgatgg ccacacgttg tttttgacca cctgataggc
    56161 tatctggatt ggcattagct ttatctgcta gtccaacctt ttcaagcaac tccattccca
    56221 attcctcagc ttcttcctta gtcatcaact tgtgctcaat aggagcaaag gtgatgttgt
    56281 ccaatacaga catatgaggg aagaggttga agtgttggaa taccatgccg atattttcac
    56341 ggacgtggtc aacattggtt gttttttcag ttaaatcata gccgttcaca gtgatgtgac
    56401 cgctagtgac ttcttctaaa agattgaggc tacggaggaa agttgactta ccagaacctg
    56461 aaggaccgat gatacaaaca acatctcctt catagaactt agtcgtaatt ccttttagga
    56521 cttcattttt tccatagtgc ttgtgtaaat catttacatc aatttttaat tttgccatta
    56581 acgaatcctc ttttctaagc gtttcgctag tctagtcaaa agtgtgataa ttacaagata
    56641 gaagatagca aggattgcat acatcttgaa actttggtag ttacgagcaa tgataatctt
    56701 accagtttgg aagagttcaa ccaaaccgat agcagatacg atagttgtat ctttaagagc
    56761 gataacgaat tggttgacaa agtttggcaa catcaattta gttgcttgtg gcaagataat
    56821 cttacgcatg gtttttccat aagagatacc caagcttcgg ctggcttcca tttggccaac
    56881 tggaacggcc tgaataccac cacgaacgat ttcagcgata taagcagccg cattgagtga
    56941 gagggcaatg gttccagcta caaagtcgtt aattgggctt tgttggcctg tgatagactc
    57001 gatgaagttt ggaattcccc agaagatgaa ggctgcaaga atcatcaatg gaataccacg
    57061 aataacgtca acgaaaatct cagagatgac gcgaagagat ttgtatgggc taacgctaaa
    57121 cataccgaag ataattccga tgacaatggc aatagcaaat gagataagag ctagagcaag
    57181 agtgatacca agaccgctaa ggagttgttt gtagttgttt tgaagcaagc cccagagcgt
    57241 tgtttcgtca acagtacttg ttgaagcagt tgaagattcg ctagctaggt atttgtcaag
    57301 aatcttttgg aattcaccgt ttgccttaag gtttgcaagt ccgttgttga acatttcaat
    57361 cagttctgga tttgctcctt ttttaacggc aaaggctgtt tcaccgattg gagttccaga
    57421 gattggagtt ttcaattttt gaccttggct gatagaatat ttgagaacag gttcatcatc
    57481 cataacggca tcaatggcac cagtgtttaa actgtcatac attgaagaac catcagcaaa
    57541 ggttttgatt ttgtaaccgt atttgctttg attttctgtt aggaaggttt gagaagcagt
    57601 tccgttttta acaccgactg tctttccttt tagatcttca taagaagcaa tattgcttga
    57661 ttctttgaca ccaagaatgg tattagcagt gtagtatgat tctgagaagt caaaagttgc
    57721 cttacgagca tctgtgacag acataccagc aatgatacca tcggcttgac cagcttggac
    57781 agcactgata gcagcatcaa aaccagggtt ggtgatttca atttcaaaac cttggtcttt
    57841 agcgattgcc ttaatcaatt ccatatcaat accagtgtat tggttgcttg aattttggaa
    57901 aacaaaaggt gcaaaagaag aatcgctggc aatgatatat ttagccttaa caggaatagc
    57961 ttttaatcct gcgagagtag ttgtagttgg cactgctgaa gatgatgaag cagtccattt
    58021 cttgataatt ttatcaagac taccatcttt tttcatttca gccaaggctt ggttaaattc
    58081 agtaaccagg tgctcgtatt tacttccttt tttcacaccg aaagcaaaac ttcctacagc
    58141 ttcaccatcc atttcaatat ggaggtcttg accttggtta atggcatatt cgataacagg
    58201 tttgtcatcc atcatggcat cgatggcacc agcactcaag ctgttgttca ttaaatcacc
    58261 agtgtcaaat gttttaatag taaagccgta tttatctttg attgtttcaa ggaaacgttg
    58321 agcggcagtt ccgtttttaa caccaacggt tttgccagtt aattggtcgt acttgctaat
    58381 tttgtgtgac tttgtagtag caatgacaac ttttgtatca tagtaagtat cagacatggt
    58441 gaagactttt tcacgttctt tagtctttgt catccctgcc atgatagcgt cggcttgccc
    58501 agcttgaacc gcattgaccg ctgcgtcaaa tccaggatag gacatctgaa tgttccagcc
    58561 tttaatctca gcgactttgt taataatgtc aacatcaatt cctttataag tttgatctga
    58621 atctttaaac tcaaaaggtg cataggcggt atcagaaaca atcttaatcg tttctgcttt
    58681 ggcaatacct aatgagaaaa ttgggaataa aattagcaaa aatgctagaa attttttctt
    58741 catttttagt ctccttttcc gaatattctc tcattatatc agaaaaagta aaaaaaggca
    58801 aatttttata ttttccgtgt cagaaaatat aacattgatt tttccttttc tttcttgaat
    58861 tgctattaaa aagtgctata ataatagtat atatagaaga aaagaggacg gggatatgaa
    58921 gaataaaaga atatttaaag acttccaagc ttcaaaaatg aatttaaaca tttacacaag
    58981 ccccttgtta gcctttgttt ttgttttcat aggagagttt gtggcttata ctttatatgg
    59041 tattagtttg ttagctctca tcggacttgc tagaaatttt ggagaggctg gtcaaaatct
    59101 tgcaagctac ttgcagacct tgcatcagag cttgacggat aaaacaagtg actttcgttt
    59161 aattttagga ttactggcct ttggttttat tcttaacact gtgttcagat ggacaagaaa
    59221 agttgagaaa agacctattc gaaccttggg attttataga gagaatttcc tcagcaatct
    59281 tctgaaagga tttagtctag gcctggcact ttttcttctg accttgttag gtttagtggt
    59341 cttaggtcaa tatcgtttgg aatccattca cttgaatcct tattctcttg cctttgtcgt
    59401 ctttactatc ccattttgga ttttacaggg gacagcagaa gaagtggtgg cccgtgcttg
    59461 gctacttcct caattggcct caagaaccaa tctaaaacta gctattctta tatctagcct
    59521 gttctttacc ctgcttcata tgggcaattc tggcctcacc cctctatctc tagtaaatct
    59581 ctttttattc ggagttgcca tggctcttta ccttctcaaa actgatacag tttggggtgt
    59641 tgcaggtatt catggtgctt ggaattttgc tcagggtaat ctctttggga ttttagttag
    59701 tggtcaaccg tcaggaacgt ctctgatgac ctttttacca caaggcaatc aagattggct
    59761 atcaggtggt tcttttggca tagaaggttc cattatgaca agtctggtat tactactgct
    59821 gattgtctat cttgctaata aattaaagaa agaaaatgaa aggatgtgac ttcggtccgt
    59881 ccttttcttc gtgaaaatac tataagtatg ctaaaatagg aatagcacat ggagagagga
    59941 ttcttatgat caatcacatt acagataatc aatttaaact agtatcaaaa tatcaaccat
    60001 caggagatca accccaagct atcgagcagt tggtggataa cattgagggg ggagaaaaag
    60061 ctcagattct gatgggggcg actggaacag ggaagaccta tactatgagt caggtcattt
    60121 ctaaagtcaa taaaccaact ctggttattg cccacaataa aactctggct ggtcagctct
    60181 atggggagtt taaggaattt ttccctgaaa atgcagttga gtatttcgta tcctactatg
    60241 attattacca gccagaggcc tatgtccctt ctagcgatac ctatattgag aaggatagtt
    60301 ctgtcaatga cgagattgac aagcttcgcc actcagctac ctcagccctt ttggagcgta
    60361 atgatgttat tgtcgtggcc tcagtctctt gtatctatgg tttgggttcg cccaaggaat
    60421 acgctgatag tgtcgttagt ctccgtcctg gtctagagat ttctcgtgat aaactcttga
    60481 atgacttggt cgatattcag tttgaacgca atgatattga tttccaacgc ggaagatttc
    60541 gcgttcgtgg ggatgtggta gagattttcc cagcttcccg agatgaacat gcctttcgag
    60601 tagaattttt tggagacgaa attgaccgta ttcgtgaagt tgaggctctg acaggtcagg
    60661 tgttgggaga agtggatcat ttagcgattt tcccagcgac acactttgtg accaatgacg
    60721 accacatgga agttgccatt gcaaagattc aggccgagtt ggaagaacaa ttagctgtct
    60781 ttgaaaagga aggtaaactg cttgaagccc agcgtttgaa acagcggaca gagtatgata
    60841 tcgaaatgtt gcgtgagatg ggctatacca atggggttga aaattattct cgccacatgg
    60901 atggacggag cgaaggagag cctccttata cgcttctcga cttcttccca gatgatttct
    60961 tgattatgat tgacgagagt catatgacca tagggcaaat caagggcatg tacaatggag
    61021 accgttcgcg taaagaaatg ctggttaatt atggtttccg tttgccgtct gctttggaca
    61081 atcgtcctct acgtcgggag gagtttgaga gtcacgttca tcagattgtt tacgtttcag
    61141 cgacacctgg tgactatgaa aatgaacaga ccgagacagt gattgagcaa atcattcgtc
    61201 caacgggact cttggatcca gaggtggaag tccgtccgac tatgggacag attgatgacc
    61261 tcttgggtga aatcaatgcc cgcgttgaaa aaaatgagcg tacctttatc acaactttga
    61321 ccaagaaaat ggcagaggac ttgaccgact acttcaagga aatgggtatc aaggtcaagt
    61381 acatgcactc ggatatcaag accttggaac ggacggagat tatccgtgac ctgcgcttgg
    61441 gtgtctttga tgtcttggtc ggaattaacc tgctccgtga aggaattgac gttcctgaag
    61501 tgagcctcgt agctattctc gatgctgaca aggaaggttt ccttcgcaac gaacgtggac
    61561 tcatccagac tattggacgt gctgctcgta acagtgaagg ccatgtcatc atgtatgcag
    61621 acacggttac ccagtctatg caacgtgcta tcgatgaaac tgcccgccgt cggaaaattc
    61681 agatggccta taatgaagag catggtatcg taccacagac aatcaagaaa gaaatccgtg
    61741 acctgattgc cgtgaccaag gcagttgcta aggaagagga caaggaagtc gacatcaata
    61801 gcctcaacaa acaagagcgc aaagaactcg tcaagaaact agaaaaacaa atgcaagaag
    61861 ccgtcgaagt gcttgacttt gaactggcgg ctcagatccg tgatatgatg ttggaagtca
    61921 aggccttgga ttaggggaat agtatgattt atttaagaaa gttaaagaga gaagatttga
    61981 tgtctttatg ggaaatggct tattcacaac ttaatccagt ttggaaacag tatgatgctc
    62041 cctattatga tgattatcag tatttttcaa attttaaaga attcgaacta caaaaatcag
    62101 aatccatttt aagcaactca aatcgccttg gtatttttgt tgatgataaa ctagttggga
    62161 ctgtttcgcg ttattgggta tgtaaacaaa caagatggat ggaattggga attggtattt
    62221 atgataaaaa attctggaac actggtattg ggaaagttgc tatgttgcag tggatagata
    62281 ggacgtttca ggattacttg gagttggagc atctgggttt gacaacttgg tcaggaaatc
    62341 ttggtatgat gaaacttgct gaaaaattaa gaatgaaaaa agaagctcat attccaaaag
    62401 ttcgttatta tcaaggtaaa tattttgata gtattaaata tggtattttg agagaagact
    62461 gggagaaaat gaatgacggt tattatcaaa tcaatggaaa ctcctgaaga gatagaaggt
    62521 aaatcccttg ttcactggca aacgtggaga gaggcttatg atgacctttt gcctgcagaa
    62581 tttcaggaga caatgacatt agaaagatgt cgattcttta gtcaaaagta tccagaaaat
    62641 acattgattg cgataggtga tctgaaggta gttggtttta tcagttatgg taactttcgt
    62701 gatgagacta ttcaagctgg tgaaattatt gctttatatg ttttaaaaga ctattacgga
    62761 aaaggcatag cacaaaagtt aatgaaagca gctttgactg ctctgaatca tttttctgaa
    62821 attttcttat gggtattgaa agataacaag cgagccattg ctttctatca aaaaatgggt
    62881 tttacttttg atggacaaga aaagatactt gaacttggaa agcctataaa ggaaaaacga
    62941 atggtattct attctaaaat aattttaaaa agtagaagct aatggcactg gtaccaagtc
    63001 tgaaaattta ataaattaga aagcgagtaa atttatgtcc cgttcccaat taacgatttt
    63061 aacaaatatt tgtctgattg aagaccttga aactcagtgc gtggttatgc agtaccgtgc
    63121 tcctgaaacc aatcgctggt ctggttatgc ctttcctgga ggtcatgtag aaaatggtga
    63181 ggcttttgcg gagtctgtca ttcgtgaaat ctacgaagaa acaggattga ctatccaaaa
    63241 tccgcaactg gtaggtgtta aaaattggcc tttggataca ggggggcgct acattgtctt
    63301 ttgttacaag gcgaccgagt ttactggaac tcttcaatct tcagacgagg gagaagtttc
    63361 ttgggtgcaa aaagaccaga ttccaaactt gaatctggcc tatgatatgc taccattgat
    63421 ggaaatgatg gaagctcccg acaagtcaga gtttttctac cctcgccgta cagaagacga
    63481 ttgggaaaag aaaatcttct agtcttttac taaataacct agctgatcca aggcttcctc
    63541 gatatagtgg aggtcttgtt gtgtttcggc ttcgactagg tggtaatgga tgccatctgt
    63601 caattcagat agaggtctaa agtcagaatg ctcgacttgt tctagaaaat gttgcacatc
    63661 tctgcgacaa gacagtttaa gcaaggtttc aatttctcca taaacgggat ggtcaatcaa
    63721 ggtattctgg acatgcccac cattatcgac aatagcaagg agttcctgac cgatttcttc
    63781 aacttgatgt ttcactttga aaagtttgtg aacataagga ttggtatcaa tttgcttata
    63841 gatgtagcca cgattggtgg ataggatagg agcgccatcg gctctcaaaa ttgcaatgtc
    63901 ctgcacaatg acctgacgtg tgacatgaaa atgttccgcc aaactttggc cattaagggc
    63961 tttaggagct tctttcaaga gttggagcag ggcttgtttg cgatcttttg tcatagcttt
    64021 tccttttaac ggcgttttcg aagcacttta tagacagcta gtgctaatgt atagtctacc
    64081 atactatgga taattgtgcc aaatccaact agtacaaata gaacatagaa catgttttct
    64141 acattggtac ccgaagttgc gtaaaaaagg acacaggcta atacttcagc aagggcatga
    64201 acaacagcca aaacaaaatt gaaaacccag gaagattttg gtttatctag ggtatcgggg
    64261 aatttttgta ggtaaagagc tcctaaagca ccaaaagata tatgggaaaa agcccgaaaa
    64321 acgataacca tgggatagcc agccatcaaa aatccaaaac tagaggctag gatgacaaaa
    64381 actgccatca agggcgacaa gaacatggct ataaaaatag cgatgtggct ccccaaagta
    64441 taggaagcag gtggaatgac aatcttgaaa ggcataacaa ttggaatcaa aatcgcaata
    64501 gccgttaaaa gggctgtcat tgtcataaat tgtgtctttt tccgtgtatt cacaagaatc
    64561 tcctttttaa ctgcatatac actagtatgg tacaataaac cagacaataa agcaagaatt
    64621 tacttgggtt tatagatcat tttttagtta aaagttatag tagattgaaa ctagaatagt
    64681 acacctctac ttctaaaaca ttgttagaaa tcgatttgac tgtcctgatc gatttgtcct
    64741 gttcttattt cgttttacta tagtaaagat ttcattaaaa agaaactgta tagagcaaaa
    64801 tctccacctt caggtttgaa agcggagatt gtttttattt tttcaaggtt tgtagtcgtg
    64861 gaacaatggc tagggttaga attgcagaaa tgaccaattc agcaattgaa tttgttgaga
    64921 taacggttgc cagaagaagt tggatatttc cattataaac atttccaaat aggaagaaga
    64981 ttcctccaag gacaaagata gtatttgtca aggaaccaag ggctccagct aaaatcagac
    65041 cagtcttgtt tttcatcagt ttatagacta agtaaggagt taaaccaatc aaaatacgtg
    65101 ggacgatggc aatgatagct gagtagatgt ttccgtttgg tacgaaggga gagaagaggt
    65161 agcttgtcgg tagaatcgta atcgtgttaa ccgtcaagct aagtagcccc atcaaaaatc
    65221 caagtgtaac cccaactcgt ggaccataaa taatgctggc aataatgaca ggaatatgaa
    65281 caatggtcgg tttgattgga aatggaaaaa ggttaaagat aagtgagctc agaaagtgta
    65341 tcacgagcat ggtagcaaaa aagatagcaa tgggtgcaat attagagcgt tttttcatcg
    65401 agagtttcct ttattctttc taaaataatt gtgaggtcag ctaaagctcc tcgtccgtgg
    65461 tctccacaag ctagtaggga ttccttagga gcaatcagct gatagccgta ggtttctaat
    65521 gttttcagat tattctgagt tactggatgg tcatacattt ttgtattcat agcaggagct
    65581 attagtttgg gaatatgact tggcagggct agagctgtac tggttaccat gttgtccgca
    65641 aatccgtgag ctagttttgc aatagtgtta gcagttgcag gtaccacgat aaataaatct
    65701 gctttttttc caagttcgat atgattgacc tgatcaggat agggttcctt catgacatcc
    65761 aagtggacag gattctgtga gagtacctgt agtgtcaaag gttggataaa ctctgtagca
    65821 gcctgagtca ttaagacagt gacttgatgg ccttgttttt ttagagaact gactaaatct
    65881 gccgacttat aagaggcgat tgaacccgtt acagccaaga gaatgtttgc catagttttc
    65941 ctttctaaga atgataggct tgaatttttt caaggaggag ttctgcaatt tcttctttag
    66001 tctggactgt ttgaagctga tttttctcaa caaatatagc tcggtgctga cctgctgaaa
    66061 tttgagtcag gtcattcgcg atgattaaat ctgcttgatt cttgataaga ctttttcgtg
    66121 caatgtcaac cagatgatct tcggtaacat caaccagcag tttgaaacca atcagatgaa
    66181 tagtaggatt ccattccttg actagggata tgattttggg tgtcttttta aggaacaaaa
    66241 cctgaacctc atcagttgaa gaaatcttgg cctgatgatt ctgcttgctt aaaaattctt
    66301 ttagattgga gctagcctga acttcctcaa gccctgtcat ataaacagga gtgtagtcag
    66361 aaacagccat tgagtggatc aagacctgat aatcctgaac acgttcttgc atttctatta
    66421 gaaggtcctt ggtattggta atttctcgaa tacttaggtt aggatgaggc tctggcttca
    66481 gagctcgttt tgtcgtaatt aaacaaactt catgccctgc aaaaagcaaa gtctctgtga
    66541 taattttccc caagtgacct gtagaatggt tagtgataga gcggacgcta tcgatagctt
    66601 cactggtacc gcccgatgta actaaaattt tcatagcact attgtacaca aaaataagcg
    66661 gtaagtaaaa tgaaagtgat aaatttttgg taaaaacgaa gatttactat agtttcaaac
    66721 tataaaacca tataaaattt aagaaaggac tctaaaagcc ttaaaaacag agatatttac
    66781 gaacgtttag agagttttag gatgttaaaa atcttgtttt gtgatataat gaattatcat
    66841 ataagaggtt agaggaattt tgaatgaaaa cagatattga aatcgcacag agtattgagt
    66901 tgaagccaat tgttgatgtt gtagagaaac ttggtatttc ttatgacgat ttggagttgt
    66961 acggaaagta caaggctaaa ctcagctttg ataaaattcg tgcagttgag agcaatccag
    67021 tcggtaaatt gatcttggtt actgccatca acccaacacc tgcaggtgaa ggaaagtcga
    67081 cacttaccat tggtcttgcg gatgccttga acaagattgg caagaaaacc atgattgcta
    67141 tccgcgaacc gtctcttggt ccagtcatgg ggatcaaggg tggtgctgct ggtggtgggt
    67201 atgcacaagt tctgccaatg gaagacatca acctccactt tactggagat atgcatgcta
    67261 ttacaactgc caacaatgcc ctttctgcct tgattgacaa ccacttgcac caagggaatg
    67321 agctggaaat tgatcaacgt cgtatcctct ggaaacgcgt tgtggacttg aacgaccgtg
    67381 cgctccgcca tgtgactgtt ggtcttggtg gtcctctaaa cggtattcca cgtgaggatg
    67441 gttttgatat tacagttgct tcagaaatca tggcaattct ttgcttggca acggacatcg
    67501 aggacttgaa acgtcgtttg gcgaatatcg ttattggtta tcgctatgac cgtacgcctg
    67561 tttctgtagg tgatttgcag gttgagggtg ccttggcttt gattttgaag gatgctatta
    67621 agccaaactt ggttcagaca atttacggta cacctgcctt tgtacacggt ggtccatttg
    67681 ccaatatcgc tcatggctgt aactctgttt tggcgacgac aacagccctt cacttggctg
    67741 attacactgt tactgaagct ggttttggtg cggaccttgg tgctgagaaa ttccttgata
    67801 tcaagacacc aaacttgcca acatctccag atgcagttgt tattgtcgca acccttcgtg
    67861 cccttaagat gaatggtggt gtggctaaag acgctctgac tgaagaaaat gtagaggcag
    67921 ttcgtgcagg ttttgctaac ttgaaacgcc acgttgaaaa tatccgtaag ttcggtattc
    67981 cagcagttgt agctattaac gaatttgtat ctgatacaga agctgaaatt gcagccttaa
    68041 aagaactctg tgcctcaatc gatgtaccag ttgaattggc tagtgtctgg gctgatggag
    68101 cagaaggtgg agtagcactt gccgaaacag ttgttaagac aattgctgaa aatccagcta
    68161 actataaacg tttgtacgat aatgaccttt ctgtccaaga aaagattgaa aaaattgtca
    68221 ctgaaatcta tcgtggtagc aaagtgaact ttgagaagaa agctcaaaca caaattgctc
    68281 aaatcgttca aaacggttgg gacaaattgc caatctgtat ggctaaaact caatacagtt
    68341 tctcagacaa tccaaatgcg cttggagcac cagaaaactt tgaaattacc attcgtgaat
    68401 tggtaccaaa attaggtgca ggcttcatcg ttgccttaac tggtgatgtt atgaccatgc
    68461 caggtcttcc aaaacgtcca gcagctctca acatggatgt tgaaagcgat ggaactgtac
    68521 taggcttgtt ctagtggatt gaaattgact ttaagtgagt ttggaaataa tatccaagct
    68581 cattttttct cagactgcaa gcagttcatc aataagattt atactcttcg aaaatctctt
    68641 caaactacgt cagcttcacc ttgccgtagg tatatgatac tgactctgtc agttctatcc
    68701 acaacctcaa aacagtgttt tgagcaacct gcggctagct tcctagtttg ctctttgatt
    68761 ttcattgagt ataagtagat agaaaagtta tatactatct attgaaaata ttataaatca
    68821 gatacaaaga caggtgaaac cttctgtgtt atactagaga tatgttagat ttgaaagaat
    68881 acggtatcgt catgtggccg gaggagaaag tcatttcttt ccgtgagaaa cttctcgctt
    68941 ggtatgatga aaacaaaaga gatttgcctt ggaggagaag taaaaatcct tatcacatct
    69001 gggtatctga aatcatgctt cagcagacca gggtggatac agttatccct tactacgaaa
    69061 gattcctgga ctggtttcca actgtcgaaa gtctggcaac tgcgcctgag gagagtttac
    69121 tgaaagcttg ggagggcttg ggctattatt ctcgagttcg caatatgcag gctgcagccc
    69181 agcagattat gactgacttt ggtggccaat ttccaaatac ctatgaagga atttccagct
    69241 tgaaagggat tggaccttac acagcaggag ccatttccag tattgctttt aacttgcctg
    69301 agccagctgt agatggtaat gtcatgcggg tcttggcgcg tctgtttgaa gtcaaccacg
    69361 atattgggat tccaagtaat cgaaaaattt ttcaggcaat gatggagatc ttgattaatc
    69421 cggatcgtcc gggtgatttt aatcaagcct tgatggactt agggtctgat attgagtctc
    69481 ctgtaaatcc cagacctgaa gaaagcccag tcaaggactt tagtgcggca tatcagaatg
    69541 gaaccatgga ccgttatcca attaaatctc ctaagaaaaa gccggttcct atttatctta
    69601 aagccttagt tgtgaaaaat tctcaaggac aatttttact tgaaaaaaat gaaagcgaaa
    69661 agctcttggc aggtttttgg catttcccct ttatagaagt tgataacttt tcgcaagaag
    69721 agcagtttga cctctttcat caggttgcgg aagaaagtgt gaactttggc cccagtccag
    69781 aagagagttt ccagcaggac tatgacctag atgttgattg gcttgatgtt tgttttgata
    69841 cagtccagca tgtttttagt catcgaaaat ggcatgtaca gattgtagca ggtcaggtga
    69901 gtgacttcca tgatttttca gatagggaag ttcgttggct ttcaccagaa gaattcaaga
    69961 attacccact tgccaaaccc caacaaaaaa tctggcaggc ttatgcacaa gccaacttag
    70021 acagtagcca agactagcta ttgtgtcttc tgactatttt ttggtataat agtagagaaa
    70081 aaggtgaaca tatgaaaaaa atactaattg tagatgatga gaaaccaatc tcggatatta
    70141 tcaagtttaa tatgaccaag gaaggttacg aagttgtaac tgcttttaat ggtcgtgaag
    70201 cgctagagca atttgaagca gagcaaccag atattattat tctggatttg atgcttccag
    70261 aaattgatgg tttagaagtt gctaagacca ttcgtaagac aagcagtgtg cccattctta
    70321 tgctttcagc caaagatagt gaatttgata aggttatcgg tttggaactt ggggcagatg
    70381 actatgtaac gaaacccttc tccaatcgtg agttgcaggc gcgtgttaaa gctcttctgc
    70441 gtcgttctca acctatgcca gtagatggtc aggaagcaga tagtaaacct caacctatcc
    70501 aaattgggga tttagaaatt gttccagacg cctacgtggc taaaaaatat ggcgaagaac
    70561 tagacttaac ccatcgtgaa tttgagcttt tgtatcattt agcatcgcat acaggtcaag
    70621 tcatcacgcg cgaacacttg cttgagactg tctggggtta tgactatttt ggtgatgtcc
    70681 gtacagttga tgtgactgta cgacgtctgc gtgagaagat tgaagatacg cccagccgac
    70741 cagagtatat cttgacgcgc cgtggagtag ggtattacat gagaaataat gcttgattta
    70801 ctgaaacaaa ccatttttac cagagatttt atctttatcc tgattttgtt aggtttcatc
    70861 cttgttgtga ccctcttatt actggaaaat agacgtgata atattcagtt gaagcaaatc
    70921 aatcaaaagg ttaaagattt gattgcagga gattattcca aggttcttga tatgcaaggt
    70981 gggtctgaaa tcaccaatat taccaataat ttgaatgact tgtcggaggt tattcgtctc
    71041 actcaggaaa atctagaaca agagagtaag aggctaaata gtattctgtt ttatatgaca
    71101 gatggggttc ttgcgaccaa ccgtcggggt cagattatca tgattaacga tacagccaag
    71161 aagcaactgg ggttggttaa ggaagatgtt ctgaatagaa gcattttgga attgctcaag
    71221 atagaagaaa actatgaatt gcgtgatttg attacccaaa gtccagaatt gttgctagat
    71281 tcccaagata tcaatggcga atatttgaac cttcgagttc gctttgcctt gatacgtcga
    71341 gagtctggct ttatttcagg tttggtggct gttttgcatg atacgacgga gcaggagaag
    71401 gaagaacgcg aacgaagact ctttgtttcc aatgttagcc atgagttacg gactcctctg
    71461 actagcgtaa aatcctatct tgaagccttg gatgaggggg ctttgtgtga aactgtagca
    71521 ccagacttta tcaaggtttc tcttgatgag accaaccgta tgatgcgcat ggtgacggat
    71581 ctcctccatc tttcacgtat tgataatgct accagtcacc tagatgtgga actgattaac
    71641 ttcactgctt ttattacctt tatcctcaat cgttttgaca agatgaaagg acaggaaaag
    71701 gagaaaaaat atgagttggt gagagattat cccatcaatt ctatctggat ggaaattgat
    71761 acagataaga tgacgcaggt tgtcgacaat attttaaata atgctattaa gtattcgcca
    71821 gatgggggta aaatcactgt cagaatgaag acaactgaag accagatgat tttatccatt
    71881 tctgaccacg gtttggggat tcctaagcag gatttaccac gtatctttga ccgtttctat
    71941 cgtgtggatc gtgctagaag tcgtgcgcaa ggtggtacag gtctaggact gtctatcgct
    72001 aaagaaatta tcaaacaaca taagggcttt atttgggcca agagtgaata cggcaagggt
    72061 tcaaccttta ccattgtgct cccttatgat aaggatgcag tgaaagaaga agtatgggag
    72121 gatgaagtag aagactagaa tgagtgaaat aggctttaaa tacagtattt tagcgtcggg
    72181 ttccagtgga aattcttttt atctggaaac ctcaaaaaag aagcttttag tagatgcagg
    72241 cttgtctggc aagaaaatta ccagtctgct agctgaaatt aaccgtaagc cagaagacct
    72301 ggatgccatc ttgattaccc atgagcattc agatcatatc catggagtag gcgttttggc
    72361 tcgcaagtat ggtatggatc tttatgccaa tgaaaagacc tggcaagcta tggaaaatag
    72421 taaatatctt ggcaaggtgg attcttcgca aaagcatatt tttgaaatgg gtaaaaccaa
    72481 aacctttgga gatatcgaca tcgagagttt tggtgtaagc catgatgcag tcgcaccgca
    72541 gttctatcgc tttatgaagg atgataagag ttttgtcctt ttgacagata caggttatgt
    72601 cagtgaccgt atggcgggca ttgtcgaaaa tgcggatggc tatcttatcg aggccaacca
    72661 tgatgtagag attttgcgat caggttctta cgcttggcga ctcaaacaac gaatcctatc
    72721 tgaccttggt cacctttcta acgaggacgg tgctgaagct atgattcgga cgctaggaaa
    72781 tcgtactaag aagatttacc ttgggcattt atctaaggaa aataatatca aggaactggc
    72841 tcatatgacc atggtcaatc agctggctca agctgatctg ggagtcggag tagactttaa
    72901 ggtttatgat acctcaccag ataccgcaac accattgaca gagatataga aagaacgctg
    72961 agaaggtgtt ctttttatat tgactgaaca cctaaaaagt aatacaatgg tgttaccatt
    73021 aaaaaaggga gcacaaaaga tgactactat tacattaaaa gtttctgaag ctgataaaac
    73081 atttatgaaa gcaatggcta agtttgaagg agtttccctt tcggaactta ttcgcaccaa
    73141 aactcttgaa gccctagaag atgaatacga tgctcgtgtg gcagatttag cctatcaaga
    73201 gtatttagaa gacttggaaa aaggagttga actcattact tgggaagaaa tgatgcatga
    73261 tttaggcttg aaggatgaat aatttgtata aattagttcc aacaagacgt tttatcaagc
    73321 aattgaaaaa attggaccgt tatacgcaga agctaattac aaactattta caaaccaatg
    73381 ttttggaagg tccaagacga cacggaaagg ctttggttgg taatcgcgtt ggtcaatggc
    73441 gctatagaat tggtaattat cgagttatcg tacaaattgt agatgatgaa ttagtcgttg
    73501 ctactctaga agttggtcat cggagagata tttattgaat taaagctgag taataacaat
    73561 atagaaagta aggagagtaa aaatttgaag aaaaaatggt tatttgcaga ttattatgat
    73621 acaacaatta ttttacttgc tttaatctct gttattctgg tattacttgg atttgctgag
    73681 atgactgatt tggacaatcc gccttatagt attattgatt tagtaatctg gggtgttttt
    73741 gtaattgatt atagttggcg cttttttatt actaaaagaa aatggcgctt tattcttgaa
    73801 aatatttttg atttattgac cattctccct ttaaatgcta tttttacagt gtttcgatta
    73861 ggacgtatct tccgcttagc aaggctgaca aaattactga aactgactcg tttacttaga
    73921 ataattggac ttacaggtaa actagaaaga aaaattagta gattcttacg aacaaatgga
    73981 ttgatttata tcttgtatgt taatatcttt attgttctag tagggagttc gattttatcc
    74041 gttgttgaag aaaaatcctt ctcagatagt ctttggtggg ctcttgtgac agtaactact
    74101 gttggttatg gtgatattgt tccagtttcc ctttttggga aatggctagc agttttactg
    74161 atgcttgtcg gtattggaac aatagggatg ctaacaagtg ctttgacgaa cttttttgta
    74221 aaggataatc cagatgaaca gataaaactt gataaactca aagacgaatt atcgagctaa
    74281 agaatattaa tagagaaaca atctgaaaaa atcgaagaac tacattgaat gataaaagac
    74341 ttagttgaaa aaatatcata aaggtgagac aaaataaaac ttgattcgag gagaaatcaa
    74401 gtaagttttg acacaataga acgcatatta tcaggtataa aaacttgata ctatgcgttt
    74461 tatagagaaa taaaataaaa tctgaacaaa tcaattagga atttaaagca ttttataaca
    74521 acgttttaga gtaatggggt gctatttcaa cttcaaccta ctataataca gaaaaaaata
    74581 cagaaaaaaa caactccctg atgattcaag gagttgtcta tagttaaatt agtttttaga
    74641 agcttcttgg aattctggat ttttccatgc ttcgtcaata atagcttgca attctttagc
    74701 agatgcttgc attttttgag tttctgcatc gttcaatgga atgtttactg gacgaacgat
    74761 accatgtgca ccaacaacag ctggttgacc gataaagaca ttctcaactc cgtattgacc
    74821 ttcttggaat actgaaagtg gaagtactgc gttttcatcg tcaaggattg ctttagtgat
    74881 acgagcaagg gctactgcga taccgtagta tgttgcacct tttttgttga tgattgtgta
    74941 ggctgcatca cgaacacctt cgaacaattc aatcaattca gcttcttgaa cattttgagt
    75001 gtctttaagg aattcttcaa gatttacacc agcgatgtta gcgtgtgacc aaacagcgaa
    75061 ctcagagtca ccgtgttcac ccatgatgta ggcgtgcact gaacgagcat ccacatccaa
    75121 tttttcagca agtgcttgac ggaaacgagc tgagtcaagt gaagtacctg aaccgataac
    75181 gcgttcttta gggaaaccag agaatttcca agttgagtaa gtcaaaacgt caactgggtt
    75241 agcagcaaca aggaagatac ctttgaaacc agattcaaca acttgagtta cgattgattt
    75301 gttgatagca aggtttttac ctacaaggtc aagacgagtt tcacctggtt tttgaggtgc
    75361 acctgcagtg atcacaacaa ggtcagcgtc tgcacagtca gagtattgag ctgcatagat
    75421 ttttttaggt gaagtgaagg caagggcgtg actaaggtca agcgcatcac caacagcttt
    75481 ttcatgcaat tgtggaattt cgataattcc aagctcttgt gcaattcctt ggttaacaag
    75541 tgcaaaagcg taagatgaac ctacagcacc atcaccgaca aggataactt ttttgtgttg
    75601 tttagttgaa gtcattgttt taaacatctc cttaatttta ttaggggatt ttccctagac
    75661 aacttcattc tatcactttt aaaaaacttt gtcacgaata tgccttatag ttctcgatgt
    75721 aaacgtttta gtggtttaga ggctgaaata gatgggaatt tatggtataa tgttgttact
    75781 tactaattgt gaaatgaggc atttattaat gcaggataaa aatttagtga atgtcaatct
    75841 gacaaaggag atgaaggcaa gttttatcga ctacgccatg agtgttatcg tagcgcgagc
    75901 tcttcctgat gttcgagatg gcttaaaacc tgttcaccgt cgcattctct acggaatgaa
    75961 tgaattgggt gtgaccccag acaaacccca taaaaaatct gctcgtatta caggggatgt
    76021 catgggtaaa tatcacccac acggggattc ctctatttat gaagccatgg tccgtatggc
    76081 tcaatggtgg agctaccgtt acatgcttgt agatggtcat gggaattttg gttccatgga
    76141 tggagatagt gctgccgctc aacgttatac cgaggcacgt atgagcaaga ttgctctgga
    76201 aatgcttcgt gatatcaaca aaaatacagt tgatttcgtt gataactatg atgccaatga
    76261 acgggaaccc ttggtcttgc cagcgcgttt tccaaacctt ttggttaatg gagcaactgg
    76321 tatcgcggtt gggatggcaa ccaatattcc acctcataat ctgggtgaaa ccattgatgc
    76381 agtgaagttg gtcatggata atcctgaagt gactaccaag gacttgatgg aagtcttgcc
    76441 tggaccagat tttccaactg gtgctcttgt catggggaaa tcaggtatcc ataaggctta
    76501 tgaaacaggt aaaggttcga ttgtcctacg ttctcgtaca gagattgaaa cgactaagac
    76561 tggtcgtgag cgtatcgttg taacagaatt tccttacatg gtcaataaaa ccaaggtgca
    76621 tgagcatatt gttcgcttgg ttcaggaaaa acgcattgag ggtatcacag cagtacgtga
    76681 tgagtcaaac cgtgaaggtg ttcgatttgt tattgaagtc aagcgcgacg cctcagccaa
    76741 tgttattctc aataacctct tcaaaatgac ccaaatgcaa accaattttg gattcaatat
    76801 gctcgctatc caaaatggta taccgaaaat tttgtctctt cgtcagattt tggatgctta
    76861 tattgagcac caaaaagaag tggttgttcg tcgtacacgt tttgataagg aaaaagcgga
    76921 agcgcgcgct catatcttag aaggtctctt gattgcgcta gaccatatcg acgaagtgat
    76981 tcgtatcatc cgtgctagtg aaacggatgc ggaagctcaa gctgagttga tgagcaagtt
    77041 taagctttct gaacgtcaaa gtcaagctat ccttgatatg cgtcttcgtc gtttgacagg
    77101 tttggaacgc gataagattc aatctgagta tgatgacctc ttggctctga ttgcggattt
    77161 agcagatatt cttgctaagc ctgaacgtgt ttctcaaatt atcaaagacg aattggatga
    77221 agttaaacgt aaattttctg ataaacgccg tacagagttg atggttggac agatcttgag
    77281 tctcgaggat gaggacttga ttgaagaatc ggatgtcttg attacccttt ctaacagagg
    77341 ctacattaag cgtttggatc aggacgagtt cactgctcaa aaacgtgggg gtcgtggtgt
    77401 ccaaggaacg ggagtgaaag atgatgactt tgttcgtgag ttagtgtcaa ctagcaccca
    77461 tgatcatctg ctcttcttca caaacaaggg acgtgtctat cgtcttaaag gttatgaaat
    77521 tcctgagtat ggtcggactg ccaaagggct accagtagtc aatctcttga aattggatga
    77581 agatgaaagt attcagacgg ttatcaatgt tgagtctgat cgcagtgatg atgcttatct
    77641 cttctttaca acccgtcacg gtattgtgaa gagaactagt gttaaggagt ttgccaatat
    77701 tcgtcaaaat ggtctcaaag cgctgaattt aaaggatgaa gatgagttaa tcaatgtctt
    77761 gttgacagaa ggagatatgg atattatcat tggtaccaag tttggttatg cagttcgctt
    77821 taatcaatca gccgttcgtg gtatgagccg tatcgccact ggtgtgaaag gtgttaacct
    77881 tcgtgaagga gacacagttg ttggtgccag cttgattact gatcaagatg aggttcttat
    77941 tatcacagaa aaaggatatg gtaagcgtac agtcgctact gaatacccaa caaaaggtcg
    78001 tggtggtaag ggaatgcaga cagctaaaat taccgaaaaa aatggcttgc tggccggtct
    78061 tatgactgtt caaggggatg aggatttgat gattatcact gatacaggtg tcatgattcg
    78121 aaccaatctt gccaatattt cacaaacagg acgtgcaact atgggagtta aagtaatgcg
    78181 cctggatcaa gatgctcaga tagtgacttt cacaacggtt gcggtggcag aaaaagaaga
    78241 agttgggaca gaaaacgaaa cagaaggtga agcataatgt ctcaaaaaaa taataaaaag
    78301 aaaaacaagc gaaaaaatct gctgacaaat atcctagcag gatttctgat attactgtca
    78361 ctggctttga tttttaatac tcaaattcga aatattttca tagtctggaa taccaataag
    78421 tatcaagtta gccaggtatc aaaagaaaaa ttagaagaaa atcaggatac agaaggcaat
    78481 tttgactttg attctgtcaa agctatctct tcggaagctg ttctaacttc tcaatgggat
    78541 gctcaaaaat taccagttat tgggggaatt gcaattcctg aattggaaat gaatttgccg
    78601 atttttaaag gacttgataa tgttaatctc ttctacggag ctggtacaat gaaacgcgag
    78661 caagtaatgg gagaaggaaa ttatagtcta gctagtcacc atatctttgg tgttgataat
    78721 gctaataaaa tgttattttc tcctttagat aatgctaaaa atggcatgaa gatttatcta
    78781 accgataaaa ataaagttta tacttatgaa atacgtgaag tcaaacgtgt gacaccggat
    78841 cgtgttgatg aagttgatga tagagatggg gtcaatgaaa tcacattagt aacctgtgaa
    78901 gaccttgctg ctacagaacg tattattgtc aaaggtgatt tgaaagaaac aaaagattat
    78961 tcacaaacat ctgatgaaat tctaacagct ttcaatcaac catataaaca attttattaa
    79021 tacaaatcag tgaaatcatg gatttcactg attttttaag attttcataa aaatatagta
    79081 aaatgaaata agaataggac gaatcgttca ggacagtcaa atcgatttct aacaatattt
    79141 tagaagtaga ggtgtactat tctagtttca atctactata aacttttatg aaatacagaa
    79201 aacgcttcct aaaacctaaa gtttgtgata taattatcaa gaaaaaagat ttaggagttt
    79261 attatggttt cttcagaatt tatctcaaag attgaatttg cttgcaataa gaaagaaagt
    79321 ctttatagtc aaagcaaatt taagtatgcg attcgttcga tgttcgcagg tgcattttta
    79381 accttcagta ctgctgcagg tgcagttggg gctgacttga ttaataaaat tgcaccaggt
    79441 agtggacgct tcctctttcc attcgttttt gcttggggct tggcctacat tgtttttttg
    79501 aatgccgagt tggtcacttc aaacatgatg ttcttgactg ctggtagttt cttaaaaaaa
    79561 atctcttgga gaaaaacagc tgagatttta ctatactgta ccttgttcaa ccttatcgga
    79621 gccttgatag cagggtgggg ctttgctcat tcggcagcct atgcgaatct gatacacgat
    79681 agtttcatct caggtgttgt tgagatgaag ttaggccgct caaatgaatt ggtcttgctt
    79741 gaggcgattt tggcaaatat tttcgtaaat attgcgattc tgtcatttat tttggtcaaa
    79801 gatggtggtg ccaaactttg gcttgtgttg tcagctattt acatgtttgt attcttaaca
    79861 aacgagcaca ttgcggcgaa ctttgcttct ttcgcgattg tgaaattcag tgttgctgcg
    79921 gattcaattg ccaacttcgg tgttggaaat atgcttcgcc actggggtgt gactttcatc
    79981 ggaaacttta tcggaggagg cctcttgatg ggtcttccat atgccttcct caataaaaac
    80041 gaagatactt atgtagatta agaaaatgag cacgattgag tcgtgctttt ttcattttca
    80101 aaataaggta atagctattt cttatatcaa aatatagaaa actgatattt gtaaactata
    80161 actcaaggtg ctacaatatc cttaataaaa tgatatggag gtcaccttat gacttgtgat
    80221 tttaaatctg aaactctaca actacatgct ggtcaagttg tggctccagc tactaagtct
    80281 cgtgcagtgc cgatttatca aacaacattt tttgtttttg atgacacgta ggaaggtgcc
    80341 gatctgtttg ccttgaggaa accagggaac atttatactc gtatcaccaa tcctacaaca
    80401 gctgcccttg aaggtggtgt tgaagcgcta gcaacagcat caggtatgac tgcagtgact
    80461 tatacgattt tggcgcttgc ccatgctggt gaccatgtag tggctgcttc gactatttac
    80521 ggtggaacct tcaatctttt gaaagaaccc cttcctcgtt atggtatcac aacaaccttt
    80581 gtcgatgttg ataatttgga ggaagtagaa gcagctatca aagacaatac caaacttgtc
    80641 ttgattgaaa ccttgggtaa ctccttgatt aatattccag acctggaaaa actggcagag
    80701 attgctcata aacatcaaat cccacttgtg tcagacaata cttttgcaat accttatttg
    80761 attaacgtct tctctcatgg cgttgacatt gccattcact ctgcgactaa gtttatcggt
    80821 gggcatggta caactattgg aggaataatt gtcgatagtg gtcgttttga ctggatggct
    80881 tcagggaaat tccctcaatt tgttgacgag ggttcaagct gccacaattt gagctatact
    80941 cgtgatgtgg gtgcagtagc ctttattata gctgttcgag ttcaattgct tcgtgataca
    81001 ggtgcagcct tgtcaccatt caatgctttc ctcttgctac aaagacttga aaccctttca
    81061 cttcgtgtgg aacgccatgt acaaaatgct gagacaattg ttgattttct tgtcaaccat
    81121 cctaaggtag aaaaggtaaa ttatccaaaa cttgcagata gtccttatta tgccttggct
    81181 gagaaatact tgccaaaagg tgtcggttca atctttacct tccacgtcaa aggtgacgag
    81241 gaagaagcac gcaaggtcat tgatcattta gaaatctttt ctgaccttgc aaacgcggca
    81301 gatgctaaat cgcttgttgt ccatccagca acaatcactc acggtcaatt gtcagaaaaa
    81361 gacctagaag cagcaggtgt cacaccaaat caaatccact tgtctatcgg tcttgaaaat
    81421 gtagaagatt tgattgaaga cttacgcttg gccttggaaa aaatttaaag taaaagaaga
    81481 taaacagtgg gttttgactc actgtttttg attttccttc atgcatgata taatggttac
    81541 agaagtctag aaagaggaac gatatgaacg aaatcaaatg tcccaactgt ggggaagtct
    81601 ttacagtaaa tgagagtcag tatgccgaac tcttgtccca agtgagaacg gcagagtttg
    81661 ataaggaact acacgatagg atgaagcagg aactggcctt ggcggagcaa aaggccatga
    81721 atgagcaaca gactaaactg gctcagaagg atcaagaaat tgcgcaatta cagagtcaga
    81781 tccaaaactt tgatacagaa aaagaattgg ccaagaaaga ggttgaacag acaagccatg
    81841 aggctctctt ggctaaggac aaggaagtac agctcttaga aaatcagttg gctaccttgc
    81901 gtttggagca tgaaaatcaa ctacaaaaga ccctttctga cctagaaaaa gaacgggatc
    81961 aggttaaaaa ccaactactt ttgcaggaaa aggaaaatga attatctttg gcttctgtta
    82021 agcaaaacta cgaagcccag ctcaaggcag ctagtgaaca agtcgagttt tataagaatt
    82081 ttaaggctca acaatctaca aaagcgattg gggaaagcct agaacagtat gcagagagtg
    82141 agtttaacaa ggttcgtagt ttcgcctttc caaatgctta ctttgagaag gataacaagg
    82201 tctcttcgcg tgggtctaaa ggggacttta tcttccgtga gtgtgatgaa aatggagttg
    82261 aaatcatttc tatcatgttt gagatgaaaa acgaagcaga cggaacagag aagaagcaca
    82321 agaatgcaga tttttacaag gaattggaca aggaccgtcg ggagaagaac tgtgagtatg
    82381 ccgttttggt gaccatgctt gaggctgata atgactactt taacacaggg attgttgacg
    82441 tcagtcacga gtatgaaaaa atgtatgttg ttcgtcctca attctttatc caattgattg
    82501 gtctcttacg taatgcggcg ctaaattccc taaaatacaa gcaggagttg gccttggttc
    82561 gcgagcaaaa tattgacatt acgcattttg aggaagattt ggatgccttt aagctagctt
    82621 ttgctaagaa ctataattca gcttcgacta actttggaaa agctattgat gaaatcgaca
    82681 aggccatcaa acgcatggaa gaggttaaga aattcctgac tacatctgaa aaccaactcc
    82741 gtctagctaa caacaaattg gaagatgtct ctgttaaaaa attgacccgg aaaaatccaa
    82801 caatgaaagc gaagttcgaa gcactgaagg gggagtagaa agcaaaaatg aacggtatta
    82861 tcaacttaaa aaaagaagca ggaatgacct cgcatgatgc ggtttttaaa ctgcgtaaga
    82921 ttttgggaac caagaaaatt ggtcatggtg gaaccttgga tccggatgtg gtgggtgttt
    82981 tgccgattgc ggttggcaag gcgacacgca tggtcgagtt tatgcaggac gagggtaaga
    83041 tctatgaggg ggaaattact ctgggttatt ccacgacgac tgaggatgct agtggggaag
    83101 tgatcgcaga aacccctgtt ttgtctccct tggatgaaaa gcttgttgat gaagcgattg
    83161 ctagcttgac tgggcctatt acccagattc cccctatgta ttcggcagtt aaggttaatg
    83221 gtcgcaagct ctatgagtat gcgcgtgctg gtcaggaagt ggagcgtcca gaacgtcagg
    83281 tgaccattta tcaatttgag cggacaagtc cgatttctta tgatggccaa cttgctcgat
    83341 tcacttttcg tgtaaaatgc agtaaaggga cttacatccg tactttgtca gttgatttgg
    83401 gtgaaaagct tggttatgcg gctcatatgt cccatttgac tcgtactagt gctgctggct
    83461 tacaattaga agacgctctt gccttggagg aaattgctga aaaagtagag gctgggcaat
    83521 tagattttct ccatccttta gagattggga caggtgacct tgtcaaagtt ttcctaactc
    83581 cagaagaggc tacagaagtt cgctttggtc gttttattga gctagaccaa acggacaaag
    83641 aactggctgc ctttgaagat gataaattgt tagccattct agaaaaacgg ggcaatctct
    83701 ataagccaag gaaggttttt agctagatcg tttaggaata aaaatcgggt gatagataac
    83761 aattgcttga taaaacccca tactaatagt agaatggttt tgggaattat aatattccaa
    83821 ttgttgcgag ttgtaggtac tcaaataatc tatatagaaa tttagaggtg tgaaatgaag
    83881 caatttaaaa ttctttcaga taaatattta gagtccatta caggttctgg tgggaactta
    83941 ggcccaggat ttggtgtgat aattccatga tgcgaaatga gtttcgagaa agggtggagc
    84001 aacttcttca acaaaaagaa ataaatgaaa atagtgagtt gagtcacctg tttcgtcttg
    84061 ctatacaaaa tttagacaga aatgaaaaac accaatcggt catggccgat ttgagtcaag
    84121 ggttgtcact ttacctcatg acgcatcatt accaggcacc taagtctgtc attgattttg
    84181 gtttatggat tgccaaagct cctagccagg aaagagggag actggctttc ttgcagatgc
    84241 ttgctcaaac cctacagggc tttcgttaaa actgtcgaac atcagaggga agactctggt
    84301 gttttttgct gatgagacta taaattttgt aaaaaatgtg atagaataga cgacggataa
    84361 aataacggag gatagcatgc aaaatagacc aatcattatt ggagtgacag gtggttctgg
    84421 tggtggtaaa accagtgttt caagagccat tttatcgcat tttcctgatg aaaagatttc
    84481 catgattgag catgattcat actacaagga tcagtctcat ttgacctttg aagagcgtgt
    84541 caaaaccaac tatgaccatc cttttgcctt tgatacagac ttgatgatcg agcagattaa
    84601 ggaattgttg gcagggcgtc cggtggacat cccgacctac gactatacag agcatacacg
    84661 gagtagcaag acctatcgtc aggagcctca agatgtcttt atcgttgagg gcattttggt
    84721 cttggaggac aagcgtctgc gcgatttgat ggatatcaag atttttgtgg atacggatga
    84781 cgatgtgcgt attattcgtc gtatcaagcg tgatatggag gaacgtggcc gtagccttga
    84841 tagcgttatt aaccagtact taggtgtggt caaaccaatg taccaccagt ttatcgagtc
    84901 aactaagcgt tatgctgata tcgtcattcc tgaaggggtt agcaataccg tggctatcga
    84961 cctgttgacg accaagattg caaagatttt ggaagaagct cgaaacagca aataatcaca
    85021 tgtggaggcc ttgcctcctt tttctatttt tccctcataa tggtacataa atggagattt
    85081 ttaggcatat ttttggtata ataataccca taaaagagca agtaaatgaa tagtaggtgg
    85141 agatggaaaa gtatttatcg gtaacaactt tgaccaaata tctgaaaatg aaattcgata
    85201 aagacccata cttggaacgg gtctatttaa ctggtcaagt ttccaacttt cgtaaacgac
    85261 ctactcacca atatttctcc ctaaaggatg accatgcagt tattcaagcg accatctggt
    85321 ctgggattta tcagaaatta gggtttgacc tggaagaagg aatgaagatc aatgtgattg
    85381 ggcgtgtaca ggtctatgaa ccaagtggta gctactccat catcattgaa aaagctgagc
    85441 ctgatggggt tggggcgctt gcgattcagt ttgaacaact taagaaaaaa ttgacagaag
    85501 aaggcctgtt tcaagaacgc ttcaagcaag ctctacccca attttctaag agaattgggg
    85561 tagtaaccag ccgtagtgga gccgttattc gagatattat cacgaccgtc agcaggcgat
    85621 tcccaggtgt tgacatcctt ctttatccta ccaaggttca aggtgaaggg gctgcggagg
    85681 aaattgctag aaatattgcg cgtgctaatc aacgggacga tttggatttg ctcattattg
    85741 gtcgtggagg tggttctatt gaggatctct gggcctttaa cgaagaaatt gtggtacgag
    85801 ctatttttga atctcgtttg ccagttatct ctagtgtggg gcatgagacg gatgtgacct
    85861 tggcagattt tgtggcagat cgacgcgctg caacgccaac agcggcggct gaactggcaa
    85921 cacctgtgac caagttggat gtattaactc atttgcaaaa tcaggaaaaa cggatggcaa
    85981 cggcagtccg aaatgttcta tctaagaaac aagaggcttt gaaaaaatgc agtcagtctg
    86041 ttatctttag acaacctgag cgcttgtatg acggttattt gcaacgcttg gaccaactgc
    86101 aactgcgttt gaaacaaagt ttgcgaactc ggatttctga taacaaacaa ttagttcaag
    86161 caagaactca tcaattagta caattatcac ctgttaccaa aatccaacgc tatcaagacc
    86221 gtttaggaca gttggacaag ctcttaggta gccaaatggc gttagtttat gacgccaagg
    86281 ttgctgaggc caagcgactt tcggaagctt tgctcatgtt ggatactagc cgaatcgtgg
    86341 cgcgtggtta tgctattgtc aaaaaagaag agtccgttgt agattcggtt gagagtttga
    86401 agaaaaaaga tcaagtaacg cttttgatgc gagatggtca agtagaatta gaggttaaag
    86461 atgtcaaaac aaaagaaatt tgaggaaaat ctagcagaac tggaaaccat tgtccaaagt
    86521 ttggaaaatg gtgaaattgc tctggaagat gcgattactg cctttcaaaa gggcatggtc
    86581 ttgtcaaaag agctccaagc tacgctggac aaggctgaaa agaccttggt caaggtcatg
    86641 caagaagacg gaacagaaag tgattttgaa tgaaaaagca agaaaaatta gctcttgtcg
    86701 agtcggcttt ggaagatttt tatggagacc agcagtttgc ctctagttta cgggagtctg
    86761 ttctctattc tattcatgct ggtggcaagc gtattcggcc ttttctcttg ttagaagttc
    86821 tggaagcctt gcaggttgcc atcaaacctg ctcacgcgca ggtagctact gccttggaga
    86881 tgattcatac agggagcttg attcacgatg accttcctgc tatggatgat gacgattatc
    86941 gaagagggcg gttaaccaat cacaagaaat tcggtgaagc tatggccatt ttggctggag
    87001 atgccttatt cttagaccca tatgccttga ttgcgcaggc agatttgcca agtcagatca
    87061 aggtggactt gattgccaac ttatcccttg cttcaggtag tctgggtatg gtggcagggc
    87121 aagttttgga tatggagggc gaacaccagc acttgtctct ggaagaactt cagactattc
    87181 atgccaataa gactgggaag ttactagcct atcccttcca agcggcagct attatagctg
    87241 aattgtcacc tgaaatgcag gtgaagctga aaactgtggg tgaattgatt ggacttgctt
    87301 ttcaagtcag agatgatgta ctggatgtga cagctagttt tgaggaaatc ggtaagacac
    87361 ctcaaaagga tctgcaggca gaaaaatcaa cctatcctgc cttgttgggc ttggaagagt
    87421 ccattgcctt ttgtaaccaa accctggatc aagctaatga aaaattggaa gaaattgccc
    87481 agcaggttcc ctttgaaaca gaatcgattg taagtgtagt agaaagtttg agaatcaatg
    87541 gctaaggaaa gagtggatgt actagcttat aaacaggggt tgtttgaaac gagagagcag
    87601 gccaagcgag gtgtgatggc tggcctagtc gtagcagtcc ttaatggaga acggtttgac
    87661 aagccaggag agaaaattcc agatgatacc gaattaaaac tcaaggggga gaaactcaag
    87721 tatgtcagcc gtggtggttt gaaactggaa aaggccttgc aggtctttga tttgtcggtg
    87781 gatggcgcga ctacgattga tatcggggcc tctactggag gttttaccga tgtcatgcta
    87841 cagaatagtg ccaagttggt ctttgcagtc gatgttggta ccaatcagtt ggcttggaaa
    87901 ttacgccaag acccacgagt tgtcagcatg gagcagttca atttccgcta tgctgaaaag
    87961 actgatttcg agcaggagcc gagctttgcc agtattgatg tgagtttcat ttcccttagt
    88021 ctgattttgc cagccttgca ccgtgtcttg gctgatcaag gtcaggtggt agcacttgtc
    88081 aaacctcagt ttgaggcagg acgtgagcag attgggaaaa atggaattat tcgagatgct
    88141 aagattcatc agaatgtcct tgaatctgta acagctatgg cagtagaggc aggtttttca
    88201 gtccttggct tggacttttc tcccatccaa ggtggacatg gaaatattga atttttagcg
    88261 tatttgaaaa aagaaaagtc agcaagcaat cagattcttg ctgagattaa agaagcagta
    88321 gagagggcgc atagtcaatt taaaaatgaa taaaaaagaa agacttgaaa aaattagaag
    88381 attggtgaca gattatcaaa tcggcacgca agaagaaatt gtagaacatt tgaaagaagc
    88441 aggtatcact gccactcagg cgacggtatc ccgagatatc aaagagttag gtattgtcaa
    88501 aattcctttg agagacaaca cctatgtcta cgaattacca aaatcaatcg taaaaagtct
    88561 gcaactggct gaagacaata tcgaatcggc tgaattgatg gataagatga tcaatctcca
    88621 agttattcca ggaaatacgg cttttgtaaa agctcagtta atcgatactt ttgcagacaa
    88681 gatttttagt tgtttgactg atgatagctc gattttagtc attgccagaa gtggaagtct
    88741 agcagaggaa atctttgaac aagtaaaaaa ttggtaggtc tatatgttac ttgaaatttc
    88801 gataaaaaac tttgccatta ttgaggctat ttccctcaat tttgaaaagg ggatgactgt
    88861 cctgactggt gaaacgggtg cagggaagtc gattatcatt gatgccatga atatgatgtt
    88921 gggagctcgt gcgacgacag atgttattcg tcatggtgca ccaaaggcag agattgaggg
    88981 gcttttctca gttgagaata gtcgcctttt acaggaaatt tttgatgagc aaggtttaga
    89041 attaggtgat gaaattatca tccgtcggga aatcttgcaa aatggtcgta gtatcagccg
    89101 tgtaaatggt cagatggtta atctgtctgt tttgcgagct attgggcaac atcttgtaga
    89161 tattcatggt cagcatgacc atgaggagtt aatgcgtccc caactgcata tccagatgtt
    89221 ggatgaattt ggtgatgccg ctttttggga cttgaaagaa acctatcaaa cgagttttga
    89281 tgcctatcgg aaaatgcgca agcaggttct gaaagtcaag aaaaaccaac aggaacacaa
    89341 ggcacgtatc gaaatgttgg aatttcaaat ggcagagatt gaggcagcaa acttgcaggc
    89401 tggagaagac ttggctctca atcaagagcg agataaactc ctcaaccaca aaaatattgc
    89461 ggatacactg accaatgcct acagtatgtt ggacaatgaa gatttttcaa gtctggccaa
    89521 tgttcgttca gctatgaatg acatggaaag tgtcgaagag tatgatcctg aataccgtga
    89581 aatttcaagc tctctgtctg agacctacta tgttttagaa gacattagca aacgtttgga
    89641 agctatcatt gaggaccttg attttgatgg caatcgcctg atgcaggttg agaatcgttt
    89701 ggacctcctt catactatta ctcgtaagta tggtgggact gttgatgatg ttttgcttta
    89761 ttttgctaag attacggaag aatacaatct cttgacaggc aataatcttt cgtctgagga
    89821 catggaagca gagcttaaga agttggaagt caatcttgtc aatttggcag gtcaacttgc
    89881 ttctgctcgt cataatttgg ctcagcaact cgaagctgag attaaacaag aactgcaaga
    89941 tctttatatg gaaaaagccc agtttcaggt tcgttttagt aagggaaaat tcagtcgtga
    90001 gggaaatgaa atggttgagt tttatatttc aaccaaccct ggagaagact ttaaaccctt
    90061 ggttaaggtt gcttctggag gggaattatc tcgtctcatg ttagccatta agtctgcctt
    90121 ttcacgtaaa gaaggcaaga ctagcattgt ctttgatgag gtggatacgg gagtttcagg
    90181 tcgtgttgct caagctattg ctcagaaaat tcataaaatt ggtcagtatg gtcaggtttt
    90241 ggctatctcc catttgccac aagtaattgc gattgcagat tatcaatttt ttattgagaa
    90301 gattagtaat gaccattcaa cggtttcgac tgttcgtctc ttgacagtcg aagagcgagt
    90361 ggaggaagtt gccaagatgt tggcaggtga tgatatgaca gaagcagccc tgacgcaagc
    90421 cagagaattg ttgagaaaca gggagaaata agatgacaga ttattatgta attggagatg
    90481 ttcacggaaa agctgggatg ctggaagacc ttctcaaaac ctgggatggt cagacccagt
    90541 tgctctttct aggtgatttg attgacagag gtgaggatag tcaccgtgtt cttgaaatgg
    90601 tcaaggactt ggtggacaat caaggggcta tctgtttgtc tggaaaccac gagtatatgt
    90661 ttttgacttg gctagatgac ccagaagaaa gttatgacca ttatcgtcgc aatggtggag
    90721 atacaaccat taactctatc ctaggtcgtc ccttggatgc accagttgat ggagtagaag
    90781 atgccaagcg ggttgccgct gaagcggcag acttggtcga attcattcgt caaatgccat
    90841 ttgtagtaga gacagacaag tatatctttg ttcacgcagg tattgatttg accttggacg
    90901 actggcatga aacaacagat tataaaaaag tatggcttag aaaaccattc cacggagctg
    90961 aaaatcatac tggaaaaacc attgtcttcg gtcatacacc ggtctatggt ttgttacagc
    91021 aagaacgcgg tacatctgag ctttggacta cagaagatgg caagattgga atggatggag
    91081 gagctgttta tggtggtgtc cttcacggga ttgtctttac agaccaagga atgacagaac
    91141 accactttat cgaaaatgac ggctttgtcg ctgaagatta gtactcctag cagggtatgg
    91201 tcttgtcaaa atatcaaaaa caatttataa taaatagata ccctgaaagg aagagaatca
    91261 tgaacttaga agaattgaaa aaacgacagg agaagatccg taacttctct attatcgccc
    91321 atattgacca cggaaaatca actctagcag accgcatttt ggaaaaaaca gagacggttt
    91381 caagtcgtga aatgcaggcc cagcttttgg atagcatgga tctagagcgg gaacgtggaa
    91441 ttactattaa gttgaatgcc atcgagttga attacactgc aaaagatgga gaaacttata
    91501 ttttccactt gattgacaca ccagggcacg ttgactttac ctatgaagtt tcacgttcgc
    91561 tagctgcctg tgagggtgct attttggtgg tcgatgcggc tcaaggaatt gaggctcaaa
    91621 ctcttgccaa cgtttatctg gctttggata atgatttgga aatcatgcct atcattaata
    91681 aaattgacct gccggctgca gatccggagc gcgtgcgtac agagattgaa gatgtgattg
    91741 gtttggatgc cagtgaagca gttttggctt ctgccaaggc tgggattggg attgaagaaa
    91801 tcctcgagca aattgtagaa aaagtaccag caccaacggg tgatgtgacg gcgccactta
    91861 aggccttgat tttcgactct gtttacgatg cttaccgtgg ggttatcctc caagtgcgtg
    91921 tcatggacgg agtggtcaaa cctggtgata agattcagct catgagcaat agtaagacct
    91981 ttgatgtggc cgaagtcggt atttttacac caaaagcggt tggtcgtgat ttccttgcga
    92041 ctggtgatgt tggttacatt gcggcgtcta tcaagacggt tcaggatact cgtgtgggtg
    92101 ataccgttac cttggcaacc aatcctgcgg cagaaccatt acatggttat aagcagatga
    92161 atcctatggt ctttgcgggt ctctacccaa tcgaatcaaa caagtacaat gacctgcgtg
    92221 aagcgcttga aaaattgcaa ctgaatgatg ctagtcttca gtttgaacca gaaacatctc
    92281 aggcacttgg atttggtttt cgttgtggat ttcttggact tctccatatg gatgttatcc
    92341 aggaacgttt agagcgtgag ttcaatattg acctcatcat gacagctccg tctgttattt
    92401 acaaagttaa tttgaccgac ggtgagtcta tggatgtgtc taacccatct gagtttccag
    92461 acccaactaa gattgcgacc attgaagagc cttatgtcaa ggcgcaaatc atggtaccac
    92521 aggagttcgt cggagcagta atggagctag ctcagcgtaa gcgtggggac tttgtgacta
    92581 tggactatat tgatgataac cgtgtcaatg ttatctatca aattcctctt gctgaaattg
    92641 tctttgactt ctttgataaa cttaagtctt caacacgtgg ttatgcaagc tttgactacg
    92701 aattgtcaga atatcgccca tctaagctgg tgaaaatgga tatccttctc aatggagata
    92761 aggtggatgc tctcagcttt atcgttcaca aggactttgc ctacgaacgt gggaaactca
    92821 tcgttgataa actcaagaaa atcatccctc gccaacaatt tgaagttcca atccaagcgg
    92881 ctattggaca caagattgtc gctcgtactg atatcaaggc ccttcgtaag aacgtacttg
    92941 ctaaatgtta tggtggtgac gtttctcgta agcgtaaact ccttgaaaaa caaaaagctg
    93001 gtaagaaacg catgaaatcc atcggatcag ttgaagttcc gcaagaagcc ttcctcagcg
    93061 tcttgagtat ggatgaagaa taagttatca gaaatgcctt tccttgttca caggaaattt
    93121 atataagaat caatagtaaa gcaggcttag atggtctgct tttttagttt ttatactctt
    93181 cgaaaatctc ttcaaaccac gtcatcgtcg ccttaccgta tgtatggtta ctgacttcgt
    93241 cagtttcatc tacaacctca aaaccatgtt ttgagctgac ttcgtcagtc ttatctacaa
    93301 cctcaaaact gtgttttgag taacctgcgg ctagcttcct agtttgctct ttgattttca
    93361 ttgagtatta gaacagaaaa atgcttggag tatttgtttg tgtgtttatt tttatataac
    93421 aaactataaa caaaacaaaa atataaaaaa gagacaaaaa agaacagaaa gtaattaaca
    93481 acgatttcat atagtgttat acttatggca taaagttaat ggaaagaagg gaaaacctta
    93541 tggtattaga ttatttcttt gacaaaaacc ttgtgctttg cttagaagcg gataatcaag
    93601 aacaactctt tgatcaggta gcaagcttgt tggaagaacg agaaattgtc actcctactt
    93661 atcgtgaagc cttgatcacg cgtgaaaagt catttccaac tggtttagat atggaatttc
    93721 taggaaagga cttgccaaat gtagcgattc ctcacacaga tattgttcat aatctagctg
    93781 agaaagtggt ggttgttcga ttagaaaaac cagtaacttt tcacaatatg atagctcccg
    93841 ataaggaagt agaagtatcc ctactcttct ttatcattaa taattcaagt tcaagtcaaa
    93901 cgaacattct tgctcagttg atgaacttct tcacaggaaa tggacatctt gaagacctat
    93961 caaaaatttc cgaaccagaa aaactttatg cttatataga tgaagcaatc gcttaatctt
    94021 gtctattaaa aaataaaatc ggaggaagtc tatatgatta aaattcttgc tgcctgcggt
    94081 gcaggtgtta actcaagtca ccaaattaaa agtactctag aagaagaact ttcaaaccgt
    94141 ggttacgatg ttcactgtga tgcagtcatg gtgaaagatg taaacgaaga ccttatgaaa
    94201 ggttacgata tctttacacc aatcgctgca acagatcttg gttttgaacc aggtatccca
    94261 gttatcgaag ctgggccaat cttattttgt atcccagcaa tgagcgctcc agtatttgac
    94321 aatattagac tccctgcgaa acaaaatacg gtatagtagt tctatgaatg atgaagcaag
    94381 taaacaacta accgatgcac gatttaagcg tcttgttggt gttcagcgta ccacttttga
    94441 agagatgtta gctgtattaa aaacagctta tcaacttaaa cacgcaaaag gtggacgaaa
    94501 acctaaatta agcctagaa
//
LOCUS       DBMVGT010000003        64144 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.003, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000003 DBMVGT010000000
VERSION     DBMVGT010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 64144)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 64144)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..64144
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.003"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(75..233)
                     /locus_tag="AC0DU4_000221"
     CDS             complement(75..233)
                     /locus_tag="AC0DU4_000221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236261.1"
                     /translation="MGDKPISFRDADGNFVSAADVWNEKKLEELFNRLNPNRALRLAR
                     TKKENPSQ"
     gene            complement(243..1553)
                     /gene="obgE"
                     /locus_tag="AC0DU4_000222"
     CDS             complement(243..1553)
                     /gene="obgE"
                     /locus_tag="AC0DU4_000222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HIN4236262.1"
                     /translation="MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGG
                     NVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMHGRGAEDLRVRVPQGTTVRDAET
                     GKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKIL
                     ADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGL
                     IEGASQGVGLGTQFLRHIERTRVILHIIDMSASEGRDPYEDYLAINKELESYNLRLME
                     RPQIIVANKMDMPESQENLEEFKKKLAENYDEFEELPAIFPISGLTKQGLATLLDATA
                     ELLDKTPEFLLYDESDMEEEAYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNF
                     DRDESVMKFARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD"
     gene            complement(1617..1751)
                     /locus_tag="AC0DU4_000223"
     CDS             complement(1617..1751)
                     /locus_tag="AC0DU4_000223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4044 domain-containing protein"
                     /protein_id="HIN4236263.1"
                     /translation="MAFGDNGNRKKTMFEKITLFIVIIMLVASLLGIFATAIGALSSL
                     "
     gene            complement(1810..1986)
                     /locus_tag="AC0DU4_000224"
     CDS             complement(1810..1986)
                     /locus_tag="AC0DU4_000224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HIN4236264.1"
                     /translation="MRSGRDKKIAGVCAGVAHYLDMDPTIVQVIWGVLTCCYGAGIVA
                     YIILWIIAPVATDY"
     gene            complement(2017..3342)
                     /locus_tag="AC0DU4_000225"
     CDS             complement(2017..3342)
                     /locus_tag="AC0DU4_000225"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HIN4236265.1"
                     /translation="MRIGLFTDTYFPQVSGVATSIRTLKTELEKQGHAVFIFTTTDKD
                     VNRYEDWQIIRIPSVPFFAFKDRRFAYRGFSKALEIAKQYQLDIIHTQTEFSLGLLGI
                     WIARELKIPVIHTYHTQYEDYVHYIAKGMLIRPSMVKYLVRGFLHDVDGVICPSEIVR
                     DLLSDYKVKVEKRVIPTGIELAKFERPEIKQENLKELRSKLGIQDGEKTLLSLSRISY
                     EKNIQAVLAAFSDVLKEEDKVKLVVAGDGPYLNDLKEQAQNLEIQDSVIFTGMIAPSE
                     TALYYKAADFFISASTSETQGLTYLESLASGTPVIAHGNPYLNNLISDKMFGTLYYGE
                     HDLAGAILEALIATPDVNEHTLSEKLYEISAENFGKRVHEFYLDAIISNNFQKDLAKD
                     DTVSQRIFKTVLYLQQQVVAVPVKGSRRMLKASKTQLISMRDYWKDHEE"
     gene            complement(3358..4401)
                     /gene="cpoA"
                     /locus_tag="AC0DU4_000226"
     CDS             complement(3358..4401)
                     /gene="cpoA"
                     /locus_tag="AC0DU4_000226"
                     /EC_number="2.4.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosylglucosyldiacylglycerol synthase"
                     /protein_id="HIN4236266.1"
                     /translation="MEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVT
                     ENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKEIVK
                     RYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLR
                     TDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYK
                     KIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRD
                     LDLYKVILEGNYRATAGREEMKEAILEYQANPAALKDLKEKAKNISREYSEEHLLQIW
                     LDFYEKQAALGRK"
     gene            complement(4516..4845)
                     /locus_tag="AC0DU4_000227"
     CDS             complement(4516..4845)
                     /locus_tag="AC0DU4_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HIN4236267.1"
                     /translation="MAYTEEQIENIKTRILTALEEVIDPELGIDIVNLGLIYEIRFDG
                     DTGQTEIDMTLTTMGCPLADLLTDQIYDAMIEVPEVTDTEVKLVWYPAWTVEKMSRYA
                     RIALGIK"
     gene            complement(4859..5968)
                     /gene="rpoD"
                     /locus_tag="AC0DU4_000228"
     CDS             complement(4859..5968)
                     /gene="rpoD"
                     /locus_tag="AC0DU4_000228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0016987 - sigma factor activity [Evidence
                     IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HIN4236268.1"
                     /translation="MATKQKEVTTFDVQVAEFIRNHKQKGTATDDEINASLVIPFTLD
                     ADGIEDLLQRIQDAGISITDNEGNPSARVLSNEEEPELSDEDLIGSTSAKVNDPVRMY
                     LKEIGVVPLLTNEEEKELALAVEAGDIEAKQRLAEANLRLVVSIAKRYVGRGMQFLDL
                     IQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINK
                     LVREQRNLLQELGQDPTPEQIAERMDMTPDKVREILKIAQEPVSLETPIGEEDDSHLG
                     DFIEDEVIENPVDYTTRIVLREQLDEILDTLTDREENVLRLRFGLDDGKMRTLEDVGK
                     VFNVTRERIRQIEAKALRKLRQPSRSKPLRDFIED"
     gene            complement(5971..7731)
                     /gene="dnaG"
                     /locus_tag="AC0DU4_000229"
     CDS             complement(5971..7731)
                     /gene="dnaG"
                     /locus_tag="AC0DU4_000229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000227865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003899 - DNA-directed RNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006269 - DNA replication, synthesis of
                     primer [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HIN4236269.1"
                     /translation="MVDKQVIEEIKNNANIVEVIGDVISLQKAGRNYLGLCPFHGEKT
                     PSFNVVEDKQFYHCFGCGRSGDVFKFIEEYQGVPFIEAVQILGQRVGIEVEKPLYSEQ
                     KSASPHQDLYDMHEDAAKFYHAILMTTTMGEEARNYLYQRGLTDEVLKHFWIGLAPPE
                     RNYLYQRLSDQYREEDLLDSGLFYLSDANQFVDTFHNRIMFPLTNDQGKVIAFSGRIW
                     QKTDSQTSKYKNSRSTAIFNKSYELYHMDRAKRSSGKASEIYLMEGFMDVIAAYRAGI
                     ENAVASMGTALSREHVEHLKRLTKKLVLVYDGDKAGQAATLKALDEIGDMPVQIVSMP
                     DNLDPDEYLQKNGPEDLAYLLTKTRISPIEFYIHQYKPENSENLQAQIEFLEKIAPLI
                     VQEKSIAAQNSYIHILADSLASFDYTQIEQIVNESRQVQRQNRMERISRPTPITMPVT
                     KQLSAIMRAEAHLLYRMMESPLVLNDYRLREDFAFATPEFQVLYDLLGQYGNLPPEVL
                     AEQTEEVERAWYQVLAQDLPAEISPQELSEVEMTRNKALLNQDNMRIKKKVQEASHVG
                     DTDTALEELERLISQKRRME"
     gene            complement(7821..8579)
                     /locus_tag="AC0DU4_000230"
     CDS             complement(7821..8579)
                     /locus_tag="AC0DU4_000230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236270.1"
                     /translation="MTAIVELKNATKIVKNGFDEEKIILNDVSLEIFERDFITILGGN
                     GAGKSTLFNTIAGTLSLTSGTIRILGEDLTKFSPEKRAKYLSRVFQDPKMGTAPRMTV
                     AENLLIAKFRGEKRGLLPRRLTSYKDEFQATIEKVGNGLEKHLNTPIEFLSGGQRQAL
                     SLLMATLKRPELLLLDEHTAALDPKTSVALMELTDEFVKKDQLTALMITHHMEDALKY
                     GNRLIVMKEGRIIQDLNQEEKAKMKISDYYQLFE"
     gene            complement(8576..9442)
                     /locus_tag="AC0DU4_000231"
     CDS             complement(8576..9442)
                     /locus_tag="AC0DU4_000231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236271.1"
                     /translation="MIVSIISQGFVWAILGLGIFMTFRILNFPDMTTEGSFPLGGAVA
                     VTLITKGVNPFLATLVAVGAGCLAGMAAGLLYTKGKIPTLLSGILVMTSCHSIMLLIM
                     GRANLGLLGTKQIQDVLPFDSDLNQLLTGLIFVSIVIALMLFFLDTKLGQAYIATGDN
                     PDMARSFGIHTGRMELMGLVLSNGVIALAGALIAQQEGYADVSRGIGVIVVGLASLII
                     GEVIFKSLSLAERLVTIVVGSIAYQFLVWAVIALGFNTSYLRLYSALILAVCLMIPTF
                     KQTILKGAKLGK"
     gene            complement(9511..10515)
                     /gene="trpX"
                     /locus_tag="AC0DU4_000232"
     CDS             complement(9511..10515)
                     /gene="trpX"
                     /locus_tag="AC0DU4_000232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4236272.1"
                     /translation="MKNKRLIGIIAALAVLVAGNLIYSSMNKSEVQNNKDEKKITKIG
                     VLQFVSHPSLDLIYKGIQDGLAEEGYKDDQVKIDFMNSEGDQSKVATMSKQLVANGND
                     LVVGIATPAAQGLASATKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHNPAQQQ
                     VELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKAGLTVETFAVPSTNEIASTV
                     TVMTSKVDAIWVPIDNTIASGFPTVVSSNQSSKKPIYPSATAMVEVGGLASVVIDQHD
                     LGVATGKMIVQVLKGAKPADTPVNVFSIGKSVINKKIAQELGITIPESVLKEAGQVIE
                     "
     misc_binding    complement(10628..10845)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            complement(10928..13624)
                     /gene="ppc"
                     /locus_tag="AC0DU4_000233"
     CDS             complement(10928..13624)
                     /gene="ppc"
                     /locus_tag="AC0DU4_000233"
                     /EC_number="4.1.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008964 - phosphoenolpyruvate carboxylase
                     activity [Evidence IEA];
                     GO_process: GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA];
                     GO_process: GO:0015977 - carbon fixation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate carboxylase"
                     /protein_id="HIN4236273.1"
                     /translation="MSLQKLENYSNKSVVQEEVLILTELLEDITKNMLAPETFEKIIQ
                     LKELSTQEDYQGLNRLVTSLSNDEMVYISRYFSILPLLINISEDVDLAYEINHQNNID
                     QDYLGKLSTTIKLVAEKENAVEILEHLNVVPVLTAHPTQVQRKSMLDLTNHIHSLLRK
                     YRDVKLGLINKDKWYNDLRRYIEIIMQTDMIREKKLKVTNEITNAMEYYNSSFLKAVP
                     HLTTEYKRLAQAHGLNLKQAKPITMGMWIGGDRDGNPFVTAKTLKQSALTQCEVIMNY
                     YDKKIYQLYREFSLSTSIVNVSKQVREMARQSKDNSIYREKELYRRALFDIQSKIQAT
                     KTYLIEDEEVGTRYETANDFYKDLIAIRDSLLENKGESLISGDFVELLQAVEIFGFYL
                     ASIDMRQDSSVYEACVAELLKSAGIHSRYSELSEEEKCDLLLKELEEDPRILSATHAE
                     KSELLAKELAIFKTARVLKDKLGDDVIRQTIISHATSLSDMLELAILLKEVGLVDTER
                     ARVQIVPLFETIEDLDHSEETMRKYLSLSLAKKWIDSRNNYQEIMLGYSDSNKDGGYL
                     SSCWTLYKAQQQLTAIGDEFGVKVTFFHGRGGTVGRGGGPTYEAITSQPLKSIKDRIR
                     LTEQGEVIGNKYGNKDAAYYNLEMLVSAAINRMITQKKSDTNTPNRYEAIMDQVVDRS
                     YDIYRDLVFGNEHFYDYFFESSPIKAISSFNIGSRPAARKTITEIGGLRAIPWVFSWS
                     QSRVMFPGWYGVGSSFKEFINKNPENIAILRDMYQNWPFFQSLLSNVDMVLSKSNMNI
                     AFEYAKLCEDEQVKAIYETILNEWQVTKNVILAIEGHDELLADNPYLKASLDYRMPYF
                     NILNYIQLELIKRQRRGELSSDQERLIHITINGIATGLRNSG"
     gene            complement(13644..14873)
                     /gene="ftsW"
                     /locus_tag="AC0DU4_000234"
     CDS             complement(13644..14873)
                     /gene="ftsW"
                     /locus_tag="AC0DU4_000234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division peptidoglycan polymerase FtsW"
                     /protein_id="HIN4236274.1"
                     /translation="MKISKRHLLNYSILIPYLLLSILGLIVVYSTTSAILIEEGKSAL
                     QLVRNQGIFWIVSLILIALIYKLRLDFLRNERLIILVILIEMLLLFLARFIGISVNGA
                     YGWISVAGITIQPAEYLKIIIIWYLAHRFSKQQEEIATYDFQVLTQNQWLPRAFNDWR
                     FVLLVLIGSLGIFPDLGNATILVLVSLIMYTVSGIAYRWFSTILALVSAASVFVLTTI
                     SLIGVETFSKIPVFGYVAKRFSAFFNPFADRADAGHQLANSYFAMVNGGWFGLGLGNS
                     IEKRGYLPEAHTDFVFSIVIEEFGFVGASLILALLFFMILRIILVGIRAENPFNAMVA
                     LGVGGMMLVQVFVNIGGISGLIPSTGVTFPFLSQGGNSLLVLSVAVAFVLNIDASEKR
                     AKLYRELENQPMNLLLK"
     gene            complement(15017..15326)
                     /locus_tag="AC0DU4_000235"
                     /pseudo
     CDS             complement(15017..15326)
                     /locus_tag="AC0DU4_000235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
     gene            complement(15658..16554)
                     /locus_tag="AC0DU4_000236"
     CDS             complement(15658..16554)
                     /locus_tag="AC0DU4_000236"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0004519 - endonuclease activity [Evidence
                     IEA];
                     GO_process: GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease"
                     /protein_id="HIN4236275.1"
                     /translation="MTKISFEIQQQIIQCFGLCFHYKDTVVSFMQTSGVPNDLILKWK
                     SEPKFVWAKNVINELNKTENGRLIIRRIATEFYKMKNIPDEVQDRDRGLDALRKLKRL
                     IGDTQQNKVNETLNNSYHRSRQEMKIQLRQQLLQKIEELKTEYYSLFSSDNPQERGYR
                     LEKIVANLFRINDIDYHDSYRNRTNTQQLDGYFRFEGFDYLVEMKWEKNPVNSPKIAS
                     LKQKVDTKLTSTRGLFLSINGFRDEVIQDFSNKDAKILFMDGQELAYILENRISLYEA
                     LKVKIIGASKTGNPNVSIINQE"
     gene            complement(16579..19662)
                     /locus_tag="AC0DU4_000237"
     CDS             complement(16579..19662)
                     /locus_tag="AC0DU4_000237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HIN4236276.1"
                     /translation="MIEFGRRSLYFSKLVRSKAKMIEFDIPLESHLPISEDAQKSFLG
                     ALAIVADTARKYFEVYINRKSFNLQLKNQLHNAAEYFDALLVSGLGNSAEYQDYIAIL
                     GTTAYYLCDYNGSSRVMINYISDDIQLLEDCMTLIKVFIDVVTDELFLNHTPIEGKYS
                     SELNTLVESYRNYILSKTEFSIDIYRDLQDKVYRNGSDFSVIIVNCLLAVVCKKINSS
                     STKLLPEFSGLDFSLWQDYIQSTGSIKELWPSQIELGKQGIFSGKSGIVQMPTSSGKT
                     ASINLTLRSAFYSNRIDNALIVAPFRALCREIYRDINAHFVDENNVIVSEVFDLPEIP
                     QDFSIFNDGKKRVFILTPEKLLFLLRNHQSFIDEIGLCIFDEAHLFDDPSRGTNFELL
                     LSTVKQIFPKGIQKILISAVIPNSEAINRWFNEDGVIVSNNSIKTTEKRVAFSDLNGS
                     NEQLYFIDPITFEEEFFVPRTVSVSELEQLGKERKQKVFPELTNANDISIYYGTKLIN
                     NGGVGIFCGRKDTVNVILRRFIDLNNRNYDLTDFLKNSDRSEVEKIGNLIGQNLGYDS
                     VEYTCSQLGVFSHHSGIPMGIRIAIEYAFSKSKINNVVCTSTLAQGINLPIKYLIISS
                     VYQAGDAIKVRDFQNLIGRAGRAGKYTEGTIILTEPNIYKSPKNKWKKQNYKALLNPI
                     NTEGCQSNILSIIQFKSVVPTDYRFAPIKFDFWNLIKERFDSSVDYRTKINNILSKLK
                     RKNSLYFKDFNSKIDQIDNTLIAIENYIASMYATELETDSLAENTFGYFLGNEEEKEK
                     IKELFILIKSKIITSSVETEIIAKNSIGLYQSELLKEWVQENKTSILSCEKEEELLGV
                     LTKKIIDFSNNKEMRKLSIENLNYISQLWIKGISYFQILESCTEKSISIEKRGKSKPI
                     DMSDIISICDNGLGYETSMVLNAINNILEKLVGEELDVLTMLIKRLKYGLPLEKEINI
                     YELGFSDRIVVQVIGQEINSVSKNQIRNEIKQKSARLEDKLSDFPSYYTQIINEM"
     gene            complement(19659..20468)
                     /locus_tag="AC0DU4_000238"
     CDS             complement(19659..20468)
                     /locus_tag="AC0DU4_000238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Hachiman antiphage defense system protein HamA"
                     /protein_id="HIN4236277.1"
                     /translation="MEKMHSYIKYLTQEDPIITDEGKQIEILHLDIQDDPEIFEDWAK
                     QFRRNYCSDDELAEMIGFMNISPKEYLENFKLPSDSGIGLSTMSGDFGEILVSDYLQY
                     IEEYVVPRTRYDSKVNKNTSTQGSDVLGYKQDSSNVSNDEVVVIEVKSSASDSSSSKA
                     KNKLQEAINHSDKDFERFSTSIVASYLRLKKSNSDQANVVERFLNITDKPFNVIYGAV
                     AVYSNQSYDIDVIKTVVSKNHRDFQKLRLLVIHSNELMKFIRELYSKASEV"
     gene            complement(20452..21228)
                     /gene="pezT"
                     /locus_tag="AC0DU4_000239"
     CDS             complement(20452..21228)
                     /gene="pezT"
                     /locus_tag="AC0DU4_000239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system toxin PezT"
                     /protein_id="HIN4236278.1"
                     /translation="MEIQDYTDSEFKHALARNLRSLTRGKKSSKQSIAILLGGQSGAG
                     KTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQENGKDSVEYTKDFAGKMVESLV
                     TELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
                     LYAINPNPARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTT
                     SAAEVLQEYLFGKWSKVEEEMLKVGEERMRDMSKSNGKDA"
     gene            complement(21228..21704)
                     /gene="pezA"
                     /locus_tag="AC0DU4_000240"
     CDS             complement(21228..21704)
                     /gene="pezA"
                     /locus_tag="AC0DU4_000240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system antitoxin PezA"
                     /protein_id="HIN4236279.1"
                     /translation="MIGKNIKSLRKTHDLTQHEFARIIGISRNSLSRYENGTSSVSTE
                     LIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGI
                     SIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA"
     gene            complement(22149..22604)
                     /locus_tag="AC0DU4_000241"
     CDS             complement(22149..22604)
                     /locus_tag="AC0DU4_000241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236280.1"
                     /translation="MGAARDFLELINHKGLPLFNPLVGDSHVNNRQEYDNTGSGNLQP
                     EKWNENAKQLYNVIMWLIILWNAKPDTPLFNFKDEVIKYKTYEPFESSIKRVNTTIKN
                     GSKGKTLTEMINGYRADNDIRDEICNFNILKNKIRDMKDQQGNTMESYF"
     gene            complement(22879..24618)
                     /locus_tag="AC0DU4_000242"
                     /pseudo
     CDS             complement(22879..24618)
                     /locus_tag="AC0DU4_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511339.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 13 protein"
     gene            complement(24781..25665)
                     /locus_tag="AC0DU4_000243"
     CDS             complement(24781..25665)
                     /locus_tag="AC0DU4_000243"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0001727 - lipid kinase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol/lipid kinase family protein"
                     /protein_id="HIN4236281.1"
                     /translation="MKKAMVIINPTSGGEKALDYKEKLENKAKEYFEYVETKITEKAL
                     DATHFAEEASREQYDAVVVFGGDGTVNEVISGIDERDYIPKLGIIPGGTGNLITKLLE
                     INQDIDGAIDELDFDLTNKIDIGKANDNYFGYIFSIGSLPEAIHNVEIEDKTKFGILT
                     YAVNTMKSVMTDQVFNIKVETENGNYVGEASHVLVLLTNYFADKKIFEENKDGYANIL
                     ILKDASIFSKLSVIPDLLKGDVIANDNIEYIKARNIKISSDSELESDVDGDKSDNLPV
                     EIKVLAQRVEVFSKPKED"
     gene            complement(25777..26631)
                     /locus_tag="AC0DU4_000244"
     CDS             complement(25777..26631)
                     /locus_tag="AC0DU4_000244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="HIN4236282.1"
                     /translation="MLGAIIGDIVGSVYEWNNIKTKDFPLFRKDCFFTDDTVMTCAVA
                     EAIMNGGQKDDFIDAMKKYGRMYPNADYGARFNAWLNSDNREPYNSFGNGSAMRISPC
                     AWIMDCGFYAKTGMWPSSRGLTSLSAEVTHNHPEGVKGAMATADAIFLCRFYFGGYCR
                     EYEQSINDNPTECKRRIKDYIEKEYDYNLSQTLDEIRPNYRFNETCQETVPQAIIAFL
                     ESRDFEDAIRNAISLGGDSDTLAAITCSIAEATYGIPDWIKDKAYSYLDEPLKDVVRR
                     WENRIKAY"
     gene            complement(26689..27447)
                     /locus_tag="AC0DU4_000245"
     CDS             complement(26689..27447)
                     /locus_tag="AC0DU4_000245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HIN4236283.1"
                     /translation="MVVYIRQSKLPSEVSINKYNAQVGAYLQGEEVILYQSFSEIKEL
                     TSEDIVVDYIMETRALLKMMGLNVPVYDYPIELKEFYGRKIYAGILGEIVNIPDNWGK
                     FIKPKAGSKVFTGRVVNGTHDLIGIGLPFDYPIWISEVVEFIAEWRCFVLDVRVLDVR
                     PYTGDYHAQFDASVIDEAISCWKDAPIAYGLDIGVTRDGRTLVVEVNDGYALGNYGLS
                     PLKSINFHRARWKEMVKPYFEKNEIFKIQQDVIF"
     gene            complement(27508..27696)
                     /locus_tag="AC0DU4_000246"
     CDS             complement(27508..27696)
                     /locus_tag="AC0DU4_000246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family transcriptional regulator"
                     /protein_id="HIN4236284.1"
                     /translation="MATDKNRIMISLDDKNLEKLENLVEDARDRRGMRLTKSQVIELL
                     LNTVDYFDDIMGAIYSKK"
     gene            complement(28018..28584)
                     /locus_tag="AC0DU4_000247"
     CDS             complement(28018..28584)
                     /locus_tag="AC0DU4_000247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236285.1"
                     /translation="MVILELYQNDYSKDLVAFDSIEDGKAFVAQIPGYTLETEDGFEV
                     EYFNPKNIPDYMEIIFNGNIVPLSKFMFDPGENVNIIWKEISNLSLKNDRVIEGYSKI
                     DAYVVNNHEVKAYVETRETNYRKAKDFLESRGYEIDRSFFGSEDGEAILYRKKGIEVW
                     HFLCHLDPMFVEIEDVEGYVKEEVGEIQ"
     gene            complement(28852..30531)
                     /locus_tag="AC0DU4_000248"
     CDS             complement(28852..30531)
                     /locus_tag="AC0DU4_000248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000150 - DNA strand exchange activity
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="HIN4236286.1"
                     /translation="MSKEKIKVYLYTRVSTSIQIEGYSLEAQKSRMKAFAIYNDYEIV
                     GEYEDAGKSDKSIEGRIQFNRMMEDIKSGKDGVSFVLVFKLSRFARNAADVLSTLQIM
                     QDYGVNLICVEDGIDSSKDAGKLMISVLSAVAEIERENIRIQTMEGRIQKAREGKWNG
                     GFAPYGYKLEDGKLFINEEEAVAIRTIFDQYVNTTIGANGISKYLENHGIRKIPRQNG
                     KNPLFDAGLIRKILKNPVYNGKIAFGRRTLEKVHGTRNEYKQVEQDEYLISEGIHEAI
                     VSDEVWQAAQVKLKSQAKKYEHVNKGKDTRTHLLSGIVKCPICGVGMFGNKCIKKKKD
                     GTKYKDFYYYGCKHRQMIRGHKCTFSKQIIEELLDDAVAEVIVKIVSNPKFASMMQEK
                     INMKVDTSEIEKEIDNYQKELRKSHSTKFKLIEEIDNLDVEDKHYKRRKQDLDDRLYR
                     MYDKIDELESSLIDAKAKKQTIEAEKLTGDNIYKVLIYFDKLYKVMNDVERRQLISAL
                     ISEIQVYKEKQSNGQWLKSITFKLPIIEENLNIGLDNDEQVECVSLLEKRS"
     gene            complement(30623..30784)
                     /locus_tag="AC0DU4_000249"
     CDS             complement(30623..30784)
                     /locus_tag="AC0DU4_000249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236287.1"
                     /translation="MDNDWNGLADLIANLIAKYAGALDLDNLPDPTPAKNQDMKNSFD
                     MAKTQIETD"
     gene            complement(31468..32190)
                     /locus_tag="AC0DU4_000250"
     CDS             complement(31468..32190)
                     /locus_tag="AC0DU4_000250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000224688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage replisome organizer N-terminal
                     domain-containing protein"
                     /protein_id="HIN4236288.1"
                     /translation="MATNKRYYWIKLKEEFFTDKRIKRLRRISGGDTYTIIYLKLLLL
                     SLKDEGKLYYDGVESDFIKELALTIDETDDDVMVTVNYLINQGLLEVVTENDEYYLTE
                     IPNLIGSETAWAEKKRRYRQNKQRTLSLMSPTHVRQEIEKDIEIDKEREGEIDKKSTP
                     IFYGEFKNVRLSKEEYKNLKEKLNSHTDIMINKLSRYMESSGKTYQNHYVTILKWYEE
                     DKDKLRQKGLNKKMNYDVGESL"
     gene            complement(32367..33584)
                     /gene="mobQ"
                     /locus_tag="AC0DU4_000251"
                     /pseudo
     CDS             complement(32367..33584)
                     /gene="mobQ"
                     /locus_tag="AC0DU4_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019213953.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MobQ family relaxase"
     gene            complement(33894..34211)
                     /locus_tag="AC0DU4_000252"
     CDS             complement(33894..34211)
                     /locus_tag="AC0DU4_000252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000968321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3847 domain-containing protein"
                     /protein_id="HIN4236289.1"
                     /translation="MMASKRLSIEEQIEKKEESIKQLQNQKRQLKKKLNEQERKARNK
                     RLIEKGAVFESIFEESIDLTKDEFYKLIKTLNDEEIRLNIMEILEERIDDNVEKSSKD
                     EIT"
     gene            complement(34267..34692)
                     /locus_tag="AC0DU4_000253"
     CDS             complement(34267..34692)
                     /locus_tag="AC0DU4_000253"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: protein motif:HMM:NF013579.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HIN4236290.1"
                     /translation="MPKRYLLDGKTPRISATNIDNGILGYYEDIDDKNYRVFENFISV
                     SFLGAVFYHKYKASLDMKIHCLKLKNKELNKEVAFYLTSIIRQALKNTEYKDQISSTV
                     LPDIKIKLPIDSRGTPDWNYMERYIEDLKLKCNIANYNI"
     gene            complement(34745..34915)
                     /locus_tag="AC0DU4_000254"
                     /pseudo
     CDS             complement(34745..34915)
                     /locus_tag="AC0DU4_000254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612340.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            complement(35080..35874)
                     /locus_tag="AC0DU4_000255"
     CDS             complement(35080..35874)
                     /locus_tag="AC0DU4_000255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000677523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236291.1"
                     /translation="MKGLWSNNLTCGYDEKIILENINIKIPEEKISVIIGSNGCGKST
                     LIKTLSRLIKPLEGEVLLDNKSINSYKEKDLAKHIAILPQSPIIPESITVADLVSRGR
                     FPYRKPFKSLGKDDLEIINRSMVKANVEDLANNLVEELSGGQRQRVWIALALAQDTSI
                     LLLDEPTTYLDISYQIELLDLLTDLNQKYKTTICMILHDINLTARYADYLFAIKEGKL
                     VAEGKPEDILNDKLVKDIFNLEAKIIRDPISNSPLMIPIGKHHVNS"
     gene            complement(35874..36881)
                     /locus_tag="AC0DU4_000256"
     CDS             complement(35874..36881)
                     /locus_tag="AC0DU4_000256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FecCD family ABC transporter permease"
                     /protein_id="HIN4236292.1"
                     /translation="MQNLIIGIQKRKNRITLFSSLFLLIIISLSFFILLIGDESYSFS
                     TLIKVLNSETVPGASFSIMEIRLPKLLAGIIAGWSFGLAGFIFQTMLRNPLASPDIIG
                     VTSSSSIAAVFCILVLKTNSLTTGIISITCGLTSSLILFLLAKKDGFSAARLIILGIG
                     FQAVTRAGTSFLLLKVARYELQEVMRWLSGSLSFTKLDDIPLVLIVSIIATILVLFFN
                     KRLEIIELGEEIAIGLGANPELSRLVLIFCAVSLTAFSTSITGPIACISFLAGPIALN
                     IGKKRSPILAGLVGILLVLLSDIFSQNILPARYPVGVVTGLLGSPYLIYLLIKMNRRN
                     I"
     gene            complement(36881..37888)
                     /locus_tag="AC0DU4_000257"
     CDS             complement(36881..37888)
                     /locus_tag="AC0DU4_000257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FecCD family ABC transporter permease"
                     /protein_id="HIN4236293.1"
                     /translation="MRNKKQINLGIIFVICLGLLITIFLSLKLGTKEINIRDFLAAFG
                     MGNTNDDFIKSIIYKRIPRTIFAILAGSSLAISGVLMQSVTRNPIADPGILGINTGAS
                     LSVVIGLSFLGISSSISHISFAIIGGLVSAIFVYAIAVSGKAGLTPIKLALSGTCVSM
                     ALSSFVSFLILPNNNVLDKFRFWQIGSLGAATLSSISTLLPFIILGHLIAIFISSDLN
                     ALAMGDEMAVGLGVNVNRIRSLAIIASVLLCSSITAIGGPIGFVGLIVPHFCGLFISK
                     DIRTMTISSSFIGAELLLICDIIGRMLGKPGEIEVGIITAIIGGPVLIYVTMKNRGVN
                     N"
     gene            complement(37878..38903)
                     /locus_tag="AC0DU4_000258"
     CDS             complement(37878..38903)
                     /locus_tag="AC0DU4_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="HIN4236294.1"
                     /translation="MKNKFFLIAILAMCIVFSACSSNSVKNEENTSKEHAPDKIVLDH
                     AFGQTILDKKPERVATIAWGNHDVALALGIVPVGFSKANYGVSADKGVLPWTEEKIKE
                     LNGKANLFDDLDGLNFEAISNSKPDVILAGYSGITKEDYDTLSKIAPVAAYKSKPWQT
                     LWRDMIKIDSKALGMEKEGDELIKNTEARISKELEKHPEIKGKIKGKKVLFTMINAAD
                     TSKFWIYTSKDPRANYLTDLGLVFPESLKEFESEDSFAKEISAEEANKINDADVIITY
                     GDDKTLEALQKDPLLGKINAIKNGAVAVIPDNTPLAASCTPTPLSINYTIEEYLNLLG
                     NACKNAK"
     gene            complement(39296..39514)
                     /locus_tag="AC0DU4_000259"
     CDS             complement(39296..39514)
                     /locus_tag="AC0DU4_000259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001207345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236295.1"
                     /translation="MALNYKPLWIQLAKKGLKKTDVIAMAGLTTNVMAQMGKDKPITF
                     KNLERICKALSCTPNDIISFEDNFSDEE"
     gene            complement(40252..41883)
                     /gene="rlmD"
                     /locus_tag="AC0DU4_000260"
     CDS             complement(40252..41883)
                     /gene="rlmD"
                     /locus_tag="AC0DU4_000260"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000914584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HIN4236296.1"
                     /translation="MLKKNDIVEVEIVDLTHEGAGVAKVDGLVFFVENALPSEKILMR
                     VLKVNKKIGFGKVEKYLVQSPHRNQDLDLAYLRSGIADLGHLSYPEQLKFKTKQVKDS
                     LYKIAGIADVEVAETLGMEHPVKYRNKAQVPVRRVNGVLETGFFRKNSHNLMPLEDFF
                     IQDPVIDQVVVALRDLLRRFDLKPYDEKEQSGLIRNLVVRRGHYSGQIMVVLVTTRPK
                     VFRVDQLIEQVIKQFPEIVSVMQNINDQNTNAIFGKEWRTLYGQDYITDQMLGNDFQI
                     AGPAFYQVNTEMAEKLYQTAIDFAELKKDDVIIDAYSGIGTIGLSVAKHVKEVYGVEL
                     IPEAVENSKKNAQLNNISNAHYVCDTAENAMKNWLKDGIQPTVILVDPPRKGLTESFI
                     KASAQTGADRIAYISCNVATMARDIKLYQELGYELKKVQPVDLFPQTHHVETVALLSK
                     LDVDKHISVEIELDEMNLTSAESKATYAQIKEYVWNKFELKVSTLYIAQIKKKCGIEL
                     REHYNKSKKDKQIIPQCTPEKEEAIMDALRHFKMI"
     gene            complement(41957..42931)
                     /locus_tag="AC0DU4_000261"
     CDS             complement(41957..42931)
                     /locus_tag="AC0DU4_000261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /protein_id="HIN4236297.1"
                     /translation="MRKKLFLTSAAVLWAVTAMNSAHAATDVQKVIDETYVQPEYVLG
                     SSLSEDQKNQTLKKLGYNASTDTKELKTMTPDVYSKIMNVANDSSLQLYSSAKIQKLG
                     DKSPLEVKIETPENITKVTQDMYRNAAVTLGMEHAKITVAAPIPVTGESALAGIYYSL
                     EANGAKVPQANKDLAQEELKALSDINAENKDKSGYDANKLNVALADIKSGLAKAKESK
                     GNLTEEDVRKIVEDTLKNYKLDQVITGNQINIIINFALNLSKSDILSNADFTKTLNDL
                     KQSIVSQAGDSFKNINLNFDADKALEDGGNFLSSLWQALVNFFKSFGS"
     gene            complement(43005..43619)
                     /gene="pmp23"
                     /locus_tag="AC0DU4_000262"
     CDS             complement(43005..43619)
                     /gene="pmp23"
                     /locus_tag="AC0DU4_000262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000476388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall hydrolase Pmp23"
                     /protein_id="HIN4236298.1"
                     /translation="MFKRIRRVLVLAVFLFAGYKAYRVHQDVKQVMTYQPMVREILSE
                     KDTPANEELVLAMIYTETKGKEGDVMQSSESASGSTNTINDNASSIRQGIQTLTGNLY
                     LAQKKGVDIWTAVQAYNFGPAYIDFIAQNGKENTLALAKQYSRETVAPLLGNTTGKTY
                     SYIHPISIFHGAELYVNGGNYYYSRQVRLNLYIIKCFTLFSTSG"
     gene            complement(43619..44593)
                     /locus_tag="AC0DU4_000263"
     CDS             complement(43619..44593)
                     /locus_tag="AC0DU4_000263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HIN4236299.1"
                     /translation="MDIYIKKAIIHQFSPDDTELFLADKFLNITPKIEEYLRKKIEHV
                     YSDEAKTGIFEEENPFFNHITDDLLETSVTLANLWKEEFSISENLKTNDLIFVQFSKE
                     GVEHFAFLRIALRETLTHLGGEVDNPIKLTQNNLPGFGTGADEALVVNLQSSKYHLIE
                     KRIKYNGTFLNYFSDNLLAVAPKISPKKSIKELEKTAQRIAESFNTDDFQFQSKVKSA
                     IFNNLEESNELSPEKLANDLFDNNLTARLSFIDQVKEAVPEPVQFDEIDASRQLKKFE
                     NQKLSLSNGIELIVPNNVYQDAESVEFIQNENGTYSILIKNIEDIQSK"
     gene            complement(44601..45857)
                     /gene="glyA"
                     /locus_tag="AC0DU4_000264"
     CDS             complement(44601..45857)
                     /gene="glyA"
                     /locus_tag="AC0DU4_000264"
                     /EC_number="2.1.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_function: GO:0070905 - serine binding [Evidence IEA];
                     GO_process: GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HIN4236300.1"
                     /translation="MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVM
                     AAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQAN
                     CAAYMSLIEPGDTVMGMDLASGGHLTHGAPVSFSGQTYNFVSYSVDPKTELLDFDAIL
                     KQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPV
                     PYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVSFK
                     EVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQ
                     NLLDEVNITLNKNSIPYESLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKN
                     SENEAVLEEVRSAVKELTDAFPLYEE"
     gene            complement(45919..46350)
                     /locus_tag="AC0DU4_000265"
     CDS             complement(45919..46350)
                     /locus_tag="AC0DU4_000265"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014947335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236301.1"
                     /translation="MLRDLQETDVKAICDINQEALGYTFSPEETASQLARLSQDSHHF
                     LLGYEDAANHVLLGYVHAEVYESLYSKAGFNILALAVSPQAQGQGIGKSLLQGLEEEA
                     KRCGYGFIRLNSANHRLGAHAFYEKVGYTCDKMQKRFIRIC"
     gene            complement(46352..46954)
                     /locus_tag="AC0DU4_000266"
     CDS             complement(46352..46954)
                     /locus_tag="AC0DU4_000266"
                     /EC_number="2.7.7.87"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003725 - double-stranded RNA binding
                     [Evidence IEA];
                     GO_function: GO:0061710 - L-threonylcarbamoyladenylate
                     synthase [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-threonylcarbamoyladenylate synthase"
                     /protein_id="HIN4236302.1"
                     /translation="MMDRIRQELEKGGAVVLPTETVYGLFSKALDEKAVDHVYQLKRR
                     PRDKALNLNIASFEDILHFSKNQPAYLQKLVETFLPGPLTIILEANDRVPYWVNSDLA
                     TIGFRMPSHPITLDLIRETGPLIGPSANISGQASGVTFEQILKDFDQEVLGLEDDAFL
                     TGQDSTIVDLSGDKVKILRQGAIKREDILARLSEISFEEA"
     gene            complement(46938..47777)
                     /gene="prmC"
                     /locus_tag="AC0DU4_000267"
     CDS             complement(46938..47777)
                     /gene="prmC"
                     /locus_tag="AC0DU4_000267"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA];
                     GO_process: GO:0018364 - peptidyl-glutamine methylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HIN4236303.1"
                     /translation="MKLAQLFSNFEEELIRQGEEAESLSFVYRSLKNLSFTDFIFALQ
                     QEVTTEEEKQFVEDIYQQLAAHKPAQYIIGQADFYGMHLKVDERVLIPRPETEELVEL
                     ILTENLETNLSVLDIGTGSGAIALALAKNRPDWSVTAADVSQEALELASENASDQNLN
                     IFFKKSDCFAEISEKYDIIVSNPPYISREDESEVGLNVLHSEPHLALFADEDGLAIYC
                     RIAEDAKDYLKDGGKIYLEIGYKQGQSVPELFRKHLPEKRVRTLKDQFGQNRMVVVDD
                     GQD"
     gene            complement(47777..48856)
                     /gene="prfA"
                     /locus_tag="AC0DU4_000268"
     CDS             complement(47777..48856)
                     /gene="prfA"
                     /locus_tag="AC0DU4_000268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003747 - translation release factor
                     activity [Evidence IEA];
                     GO_process: GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HIN4236304.1"
                     /translation="MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSKEEASNR
                     DTVIAYREYKQVLQNIVDAEEMIKESGGDADLEELAKQELKDAKAEKEEYEEKLKILL
                     LPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAEAQGWRFEVMEASMNGVGG
                     FKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDI
                     DPKDLRVDIYHASGAGGQNVNKVATAVRIVHLPTNIKVEMQEERTQQKNREKAMKIIR
                     ARVADHFAQIAQDEQDAERKSTIGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTIL
                     SGKLDEVVDALVLYDQTQKLEELNK"
     gene            complement(48853..49443)
                     /locus_tag="AC0DU4_000269"
     CDS             complement(48853..49443)
                     /locus_tag="AC0DU4_000269"
                     /EC_number="2.7.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000068157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004797 - thymidine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thymidine kinase"
                     /protein_id="HIN4236305.1"
                     /translation="MAQLYYRYGTMNSGKTIEILKVAYNYEEQGKGVVIMTSALDTRD
                     GVGYVSSRIGMKRPALAIEETTDIFGYIRDLPEKPYCVLVDEAQFLKRHHVYDLARVV
                     DELDIPVMAFGLKNDFRNELFEGSKYLLLLADKIDEIKTICQYCKKKATMVLRTQDGL
                     PVYDGEQIQIGGNETYISVCRKHYFAPEINKENEEK"
     gene            49567..49749
                     /locus_tag="AC0DU4_000270"
     CDS             49567..49749
                     /locus_tag="AC0DU4_000270"
                     /EC_number="5.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005589823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-oxalocrotonate tautomerase"
                     /protein_id="HIN4236306.1"
                     /translation="MPFVRIDLFEGRTLEQKKALAKEVTEAVVRNTGAPQSAVHVIIN
                     DMPEGTYFPQGEMRTK"
     gene            49886..51259
                     /gene="mnmE"
                     /locus_tag="AC0DU4_000271"
     CDS             49886..51259
                     /gene="mnmE"
                     /locus_tag="AC0DU4_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002906470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HIN4236307.1"
                     /translation="MITREFDTIAAISTPLGEGAIGIVRLSGTDSFAIAQKIFKGKDL
                     NKVASHTLNYGHIIDPLTGKVMDEVMVGAMKSPKTFTREDIIEINTHGGIAVTNEILQ
                     LAIREGARLAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMNIAVKQLDGSLSD
                     LINNTRQEILNTLAQVEVNIDYPEYDDVEEATTAVVREKTMEFEQLLTKLLRTARRGK
                     ILREGISTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNINGVPLKLI
                     DTAGIRETDDIVEQIGVERSKKALKEADLVLLVLNASEPLTAQDRQLLEISQDTNRII
                     LLNKTDLPETIETSKLPEDVIRISVLKNQNIDKIEERINNLFFENAGLVEQDATYLSN
                     ARHISLIEKAVESLQAVNQGLELGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLF
                     SQFCLGK"
     gene            complement(51306..52241)
                     /gene="dapA"
                     /locus_tag="AC0DU4_000272"
     CDS             complement(51306..52241)
                     /gene="dapA"
                     /locus_tag="AC0DU4_000272"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008840 - 4-hydroxy-tetrahydrodipicolinate
                     synthase activity [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HIN4236308.1"
                     /translation="MSYQDLKECKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDG
                     ILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLIAGVGTNDTRDSIEFVKEVAEFG
                     GFAAGLAIVPYYNKPSQEGMYQHFKAIADASDLPIIIYNIPGRVVVELTPETMLRLAD
                     HPNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGD
                     EMHEMFTAIAESDMKKAAAIQRKFIPKVNALFSYPSPAPVKAVLNYMGFEAGPTRLPL
                     VPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY"
     gene            complement(52297..53373)
                     /locus_tag="AC0DU4_000273"
     CDS             complement(52297..53373)
                     /locus_tag="AC0DU4_000273"
                     /EC_number="1.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000542485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004073 - aspartate-semialdehyde
                     dehydrogenase activity [Evidence IEA];
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="HIN4236309.1"
                     /translation="MGYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKS
                     LKFKDQDITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAGVVVVDNTSYFRQNP
                     DVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGA
                     GMGAILETQRELREVLNDGVKPRDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYT
                     YEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIAAF
                     PGAVLEDDVAHQIYPQAINAVGSRDTFVGRIRKDMDAEKGIHMWVVSDNLLKGAAWNS
                     VQIAETLHERGLVRPTAELKFELK"
     gene            complement(53715..53787)
                     /locus_tag="AC0DU4_000274"
     tRNA            complement(53715..53787)
                     /locus_tag="AC0DU4_000274"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(53752..53754),aa:Thr,seq:ggt)
     gene            complement(53887..54396)
                     /locus_tag="AC0DU4_000275"
     CDS             complement(53887..54396)
                     /locus_tag="AC0DU4_000275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HIN4236310.1"
                     /translation="MKKLTIRDVADIAIVAAIYVVLTVTPPLNAISYGAYQFRISEMM
                     NFMAFYNPKYIIGVTIGCMIANFFSFGLLDVFVGGGSTLVFLSLGVWLFAKYSKDYLF
                     NGLIRKDHFFFSILFSISMFTIAAELNIVAELPFFLTWFTTGIGEFASLIIGAIIIGK
                     IGRRIDLSK"
     regulatory      complement(54394..54490)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
     gene            54519..54950
                     /locus_tag="AC0DU4_000276"
     CDS             54519..54950
                     /locus_tag="AC0DU4_000276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GtrA family protein"
                     /protein_id="HIN4236311.1"
                     /translation="MKKPIQKFFNNEILAYLFFGLATTLVSILSRLVIYQLSHQELLA
                     TALANIIGILFAFITNDTIVFKQKKKNRLIRLVKFSLARLSTFLLDLFLTFLFVTQFP
                     HIIGQFVTENIDKINAIETIIAQIFIIIINYILSKVYIFRK"
     gene            55032..55409
                     /gene="mscL"
                     /locus_tag="AC0DU4_000277"
     CDS             55032..55409
                     /gene="mscL"
                     /locus_tag="AC0DU4_000277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="large conductance mechanosensitive channel
                     protein MscL"
                     /protein_id="HIN4236312.1"
                     /translation="MLKNLKSFLLRGNVIDLAVGVVIASAFGAIVTSLVNDIITPLIL
                     NPALKAAKVERIAQLSWHGVGYGNFLSAIINFIFVGTALFFIIKGIEKAQKLTGIKKE
                     KTAEKKPTELEVLQEIKALLEKK"
     gene            complement(55451..56545)
                     /gene="hemH"
                     /locus_tag="AC0DU4_000278"
     CDS             complement(55451..56545)
                     /gene="hemH"
                     /locus_tag="AC0DU4_000278"
                     /EC_number="4.98.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004325 - ferrochelatase activity
                     [Evidence IEA];
                     GO_process: GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ferrochelatase"
                     /protein_id="HIN4236313.1"
                     /translation="MKKAILMMTFGSPEEITFEGVADFFTNIRRGMRPQDHEIQTLYD
                     NYVRIGGTPLQKITRQEVALVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCI
                     CLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQD
                     SFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPW
                     IKPDVLEYLREQTEHPDHYIFVPISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMP
                     NTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNILAESEDLQMPEFVK
                     KLIEKKGRENIKMPYLIKKMLEKAGKLPKE"
     gene            56699..57922
                     /gene="pepT"
                     /locus_tag="AC0DU4_000279"
     CDS             56699..57922
                     /gene="pepT"
                     /locus_tag="AC0DU4_000279"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0045148 - tripeptide aminopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HIN4236314.1"
                     /translation="MTYPNLLDRFLTYVKVNTRSDEHSTTTPSTQSQVDFATNVLIPE
                     MKRVGLQNVYYLPNGFAIGTLPANDPSLTRKIGFISHMDTADFNAEGVNPQVIENYDG
                     GVIELGNSGFKLDPADFKSLEKYPGQTLITTDGTSLLGADDKSGIAEIMTAIEYLTAH
                     PEIKHCEIRVGFGPDEEIGVGANKFDAEDFDVDFAYTVDGGPLGELQYETFSAAGAEL
                     HFQGRNVHPGTAKGQMVNALQLAIDFHNQLPENDRPELTEGYQGFYHLMDVTGSVEEA
                     RASYIIRDFEKDAFEARKASMQSIADKMNEELGSDRVTLNLTDQYYNMKEVIEKDMTP
                     ITIAKAVMEDLGITPIIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEYVSLQTM
                     ERAVDTIIGIVAYKG"
     gene            complement(57958..58612)
                     /locus_tag="AC0DU4_000280"
                     /pseudo
     CDS             complement(57958..58612)
                     /locus_tag="AC0DU4_000280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672614.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
     gene            58610..58774
                     /locus_tag="AC0DU4_000281"
                     /pseudo
     CDS             58610..58774
                     /locus_tag="AC0DU4_000281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057566.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            complement(59064..60161)
                     /locus_tag="AC0DU4_000282"
                     /pseudo
     CDS             complement(59064..60161)
                     /locus_tag="AC0DU4_000282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148462.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
     gene            complement(60387..63506)
                     /gene="phtE"
                     /locus_tag="AC0DU4_000283"
     CDS             complement(60387..63506)
                     /gene="phtE"
                     /locus_tag="AC0DU4_000283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtE"
                     /protein_id="HIN4236315.1"
                     /translation="MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDG
                     SQSSQKSENLTPDQVSQKEGIQAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDALFSE
                     ELLMKDPNYQLKDADIVNEVKGGYIIKVDGKYYVYLKDAAHADNVRTKDEINRQKQEH
                     VKDNEKVNSNVAVARSQGRYTTNDGYVFNLADIIEDTGNAYIVPHGGHYHYIPKSDLS
                     ASELAAAKAHLAGKNMQPSQLSYSSTASDNNTQSVAKGSTSKPANKSENLQSLLKELY
                     DSPSAQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHFIPYSKLSALEEKIARMVPI
                     SGTGSTVSTNAKPNEVVSSLGSLSSNPSSLTTSKELSSASDGYIFNPKDIVEETATAY
                     IVRHGDHFHYIPKSNQIGQPTLPNNSLATPSPSLPINPGTSHEKHEEDGYGFDANRII
                     AEDESGFVMSHGDHNHYFFKKDLTEEQIKAAQKHLEEVKTSHNGLDSLSSHEQDYPSN
                     AKEMKDLDKKIEEKIAGIMKQYGVKRESIVVNKEKNAIIYPHGDHHHADPIDEHKPVG
                     IGHSHSNYELFKPEEGVAKKEGNKVYTGEELTNVVNLLKNSTFNNQNFTLANGQKRVS
                     FSFPPELEKKLGINMLVKLITPDGKVLEKVSGKVFGEGVGNIANFELDQPYLPGQTFK
                     YTIASKDYPEVSYDGTFTVPTSLAYKMASQTIFYPFHAGDTYLRVNPQFAVPKGTDAL
                     VRVFDEFHGNAYLENNYKVGEIKLPIPKLNQGTTRTAGNKIPVTFMANAYLDNQSTYI
                     VEVPILEKENQTDKPSILPQFKRNKAQENSKLDEKVEEPKTSEKVEKEKLSETGNSTS
                     NSTLEEVPTVDPVQEKVAKFAESYGMKLENVLFNMDGTIELYLPSGEVIKKNMADFTG
                     EAPQGNGENKPSENGKVSTGTVENQPTENKPADSLPEAPNEKPVKPENSTDNGMLNPE
                     GNVGSDPMLDPALEEAPAVDPVQEKLEKFTASYGLGLDSVIFNMDGTIELRLPSGEVI
                     KKNLSDLIA"
     gene            complement(63716..>64144)
                     /locus_tag="AC0DU4_000284"
     CDS             complement(63716..>64144)
                     /locus_tag="AC0DU4_000284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine motif-containing protein"
                     /protein_id="HIN4236316.1"
                     /translation="DHVRKNKADQDSKPDEDKGHDEVSEPTHPESDEKENHAGLNPSA
                     DNLYKPSTDTEETEEEAEDTTDETEIPQVEHSVINAKIAEAEALLEKVTDSSIRQNAM
                     ETLTGLKSSLLLGTKDNNTISAEVDSLLALLKKSQPAPIQ"
BASE COUNT        18774 a        13099 c        10424 g        21847 t
ORIGIN      
        1 gattcagttc gctatacatg cccgtcgtac cacaaaatcc cgtgtctgat gaggcacggg
       61 attttttagc ttctttactg agatggattt tcctttttag ttcgtgccaa tctcaaggca
      121 cgatttggat tgagacgatt aaatagttct tccaatttct tttcattcca aacgtctgcg
      181 gcggaaacaa aattaccatc cgcatctcgg aaagatatcg gtttatctcc cataccagtc
      241 tcctagtcta caaattcaaa ctcaaattta ccaatgcgga ccaaatcccc atctttagct
      301 ccacgcgcac gaagggcttc atcaaccccc ataccacgaa gctgacgggc aaatttcatg
      361 acagattcat cacgatcaaa gttggtcata ttaaagagtt tcatgagttt ttcaccagaa
      421 agtacccatg tcgcatcgtc atcacgacta atttcaaagg ctttttcttc ttcgtcaaat
      481 ccatagtaag cttcttcttc catatcggac tcgtcgtaga gcaaaaattc tggtgtcttg
      541 tctaacaatt cagctgtagc atctaaaagt gttgccagac cttgcttggt caatccagaa
      601 attgggaaga tagctggtaa ctcttcaaat tcatcataat tttcagccaa ttttttctta
      661 aattcttcaa gattttcctg actctcaggc atgtccatct tattagctac aataatctgt
      721 ggacgctcca tgaggcgaag attgtaagac tccagctctt tattgatagc taggtaatcc
      781 tcatatggat cacggccttc gctagctgac atatcaatga tgtgaaggat aacacgtgta
      841 cgctcgatat gacggaggaa ctgagttccc aaaccaacac cttgactagc cccttcaatc
      901 aaacctggca agtcggctac tgcaaaggat tcacctgatt gggtgcgaac catacctaaa
      961 tttggtacaa tagtggtaaa gtggtaggca ccaattttag gcttagctga ggtaataaca
     1021 cttaaaagtg ttgacttccc tacagatggg aatcctacta aaccgacatc tgccaagatt
     1081 tttagttcca attgtaactc acgttcctga cctggttctc cattttcaga gatttccggt
     1141 gcaggatttt ttggtgtcgc gaaacgaata tttccacgtc caccacgacc accgtgggca
     1201 acgataaatt cttgcccatg ttcaatcaaa tctgttaaaa ccttgccagt ctccgcatca
     1261 cgaacagtcg taccttgtgg tactcgaact ctaaggtcct cagcaccacg accatgcatc
     1321 cctttggtca tccctttttc accagaatca gccttgaaat gacgattgta gcggaaatcc
     1381 atcaaggtac gtagtccttc gtctacaacg aagaccacat tgcctccacg accaccatca
     1441 ccaccccaag ggcctccatt agggacatat ttttcacgac gaaaggcaac cataccatcg
     1501 ccaccattac cagccttgac cttaatctta gctgtatcta aaaacatact cattatttct
     1561 tctcacttta aaaaagggct gggaaatccc agtcactaaa ttttcttgaa tctattttat
     1621 agactactga gggcaccaat tgcagttgca aaaattccca ataaacttgc tactagcatg
     1681 ataatcacga taaacaaggt tattttctca aacatagttt ttttacgatt tccattatct
     1741 ccaaatgcca tttttctctc cttcgttaca ttctattttc tattatctta gcatgaattg
     1801 agctagtttt caatagtcag ttgctactgg tgcgataatc cataaaataa tgtaagctac
     1861 aattccagct ccgtaacagc aagtaagaac accccaaatg acttgaacga tagtcggatc
     1921 catatccaga taatgggcca ccccagcaca aacacccgca atctttttat cacgaccgct
     1981 tctcattaat tgtttttttc atagctgttc ctctttctat tcttcatggt ctttccaata
     2041 gtctctcata ctgatcaact gtgtttttga agccttcaac atgcgtctag atccttttac
     2101 aggtacagca accacctgtt gctgaagata caaaactgtc ttaaagatac gctgactgac
     2161 cgtatcatct ttagccaaat ctttctggaa gttatttgaa ataatggcat ccagataaaa
     2221 ctcatgcact cgtttcccaa agttctcagc tgaaatctca tacaatttct ctgataaggt
     2281 atgctcgttc acgtctggtg ttgcaatcag ggcttccaaa atagcaccag ccaaatcatg
     2341 ttctccatag tacaaggttc caaacatttt atcactgatg aggttgttca aataaggatt
     2401 tccgtgagca atgacaggtg ttccactggc taagctttcc aagtaggtca aaccttgcgt
     2461 ttcgcttgtc gatgccgaaa tgaagaaatc cgccgcttta tagtaaagag ccgtctcact
     2521 aggagcaatc atccctgtaa agatgactga gtcttgaatc tctaggttct gagcttgctc
     2581 tttgaggtca ttcagataag ggccatcccc agctactacc agtttaacct tgtcttcctc
     2641 tttcagaaca tcagaaaagg ctgctaaaac tgcttgaata tttttttcat aggagattct
     2701 cgaaagacta agcaacgtct tttcaccatc ttgaatccct agtttactac gcagttcttt
     2761 caaattttcc tgcttgattt ccggacgctc aaacttggct aattcaatcc cagtaggaat
     2821 gacccgtttt tcaaccttga ccttataatc agatagcaag tcacggacaa tctcactagg
     2881 acaaataacc ccatccacat catgcaggaa acctctaacc agatacttga ccatactcgg
     2941 ccggatcaac atccccttag caatataatg gacatagtct tcatactggg tgtgataggt
     3001 atggatgact ggaattttca attcacgcgc aatccaaatc cccaacaggc caagagaaaa
     3061 ttctgtctga gtatggataa tatctagctg atactgttta gcaatttcaa gtgccttgct
     3121 aaaacctcgg taggcaaagc gacgatcctt aaaagcaaag aaaggaacac ttggaatgcg
     3181 gataatttgc caatcttcgt agcgattgac atccttatct gtcgtcgtaa agataaaaac
     3241 agcatgtccc tgcttttcaa gttctgtttt caaggttcga atactggtcg caacaccaga
     3301 aacctgagga aaataggtat ctgtaaataa accaattcgc atagattacc tcacttttta
     3361 ctttctccct aaagcggctt gtttctcata aaagtccaac cagatttgta acagatgctc
     3421 ttcagaatac tctctggaaa tattcttagc cttttctttg agatctttta aggcagcagg
     3481 atttgcttga tattccaaaa tagcctcttt catctcttct ctacccgctg tcgcccgata
     3541 atttccctcc aaaatcacct tatagagatc taaatcacgc aacataatag gagcctcaca
     3601 actcgcagct tctaaaatag tcataggaaa gagctcattg taactaggca acaagaaaag
     3661 atccgctaga gcatacaatt cgcgcatccg ctctggcgat acaatgcctg gaaaaatcaa
     3721 atttttaggg ggattttcca taattttctt atagtgttca taaccatctg tcataccacc
     3781 aaaagagaag ccaccagccc agataaaggt aatctgaggc aattcctcag ccagacggat
     3841 aaagtcatca atccctttac gtttctgaac ttgcccagca cctactacga taaactgatt
     3901 gtcactaaga ccaagatctg tgcgcagtct aactacctct tcttgtggta gaggatgcca
     3961 tttttccttg ttgacaaagt taggaatata ggtcactttt tcacgtggaa taccagctgc
     4021 taccaaatcc tcaataaaca taggattgac cacaaccaag tgctccatcc ggttgtaaaa
     4081 agaaaataca tagcgtttca caatttcctt taagaaaaat ggaattttca aacttccctc
     4141 aagtgtagct ggcaagaaat gcacatagcc aatctttctc cctgagcgtt tcttttggaa
     4201 ggttgataaa taatagggaa aatcaatcgt atgaaagtga gtcacatctg cctcgatcgg
     4261 aagattttct gtaacaatca attggtcctt ggcagcacgg tgaagaagac gaactaattc
     4321 acggtaagca cctgaaactc cctgtcctgc tactttctca cttgaactca acatattgat
     4381 gcgtaatttc tttttctcca taactactat tatatcattt tctttgaata aaatcagcaa
     4441 aagaaaggag agactagagg aaaagagggg aaatttcctc gcttttccaa cagtctctca
     4501 catgctttta tatgtttact taatgcctag ggcaatgcgg gcatagcgac tcattttttc
     4561 aactgtccag gctggatacc agactaattt aacctcagta tccgttactt ctggaacctc
     4621 tatcatagca tcataaatct ggtctgtcaa aaggtctgct aagggacaac ccatagttgt
     4681 caaagtcatg tcaatctctg tttgccctgt gtcaccgtca aaacgaatct catagatcaa
     4741 accaagattg acaatatcga ttcccaactc agggtcgatg acttcttcca aggctgttaa
     4801 aatccgtgtt ttgatgtttt caatttgctc ttctgtataa gccatatttt cctcactctt
     4861 agtcttcaat aaaatcacga agcggtttgc tgcggcttgg ttggcgtagt tttctcaaag
     4921 cctttgcttc aatctgacgg atacgctcac gagttacgtt aaagactttc cccacatctt
     4981 caagtgtgcg catttttcca tcatctagtc caaaacgtag acgcagaaca ttttcttcac
     5041 ggtctgtaag agtatctaag atttcatcca attgctcacg caagacgata cgagtcgtat
     5101 aatccactgg attttcaatc acttcatctt cgataaagtc tccaaggtgg ctatcgtcct
     5161 cttcaccgat aggagtttca agagatactg gttcttgggc aatcttcaag atttcacgaa
     5221 ccttatcagg tgtcatatcc attcgttcag caatctgttc tggtgtcgga tcttgcccca
     5281 attcttgaag gagattccgc tgttcacgaa ccaatttatt gatagtttca accatgtgaa
     5341 ctgggatacg gatggtacga gcttggtccg caatagcacg agtgatagcc tgacgaatcc
     5401 accaagttgc ataagttgaa aacttgaacc ctttagaata gtcaaacttg tcaaccgcct
     5461 tcatcaagcc catatttcct tcttgaatca agtcaaggaa ctgcatgcca cgaccgacat
     5521 agcgtttggc aatggaaaca accaaacgaa gattggcttc cgcaagacgt tgtttggctt
     5581 cgatatcgcc agcttcaaca gccagtgcca actctttctc ctcttcattg gtcaagagag
     5641 gaacgacccc tatttctttc aagtacatac ggacagggtc attgacctta gcagaagttg
     5701 atccaatcaa gtcctcatcg ctgagttctg gttcttcttc attgctaaga acacgcgcac
     5761 ttggatttcc ttcgttatct gtgatagaaa tccctgcatc ctgaatccgt tgcaagagat
     5821 cttcaatccc atcagcgtcc aaggtaaaag gaataaccag acttgcattg atttcatcat
     5881 ctgttgctgt ccctttttgc ttatgattac ggataaattc tgctacctgt acgtcaaatg
     5941 ttgttacttc tttttgtttt gttgccatta ttactccatt cttctctttt gggaaattaa
     6001 acgttccaat tcttctaggg ctgtatctgt atctcctaca tggctagctt cctgcacctt
     6061 ctttttgatt ctcatattgt cctgattcaa gagagccttg tttcgagtca tctctacttc
     6121 actaagttcc tgcggcgata tctcagcagg caaatcctga gctaaaactt ggtaccaagc
     6181 tctttcaact tcctctgtct gctctgctaa aacttctgga ggaagatttc catactggcc
     6241 aagcaagtca tataagacct gaaattcagg tgtagcaaat gcaaagtctt ctcgcaaacg
     6301 gtaatcgttc aaaacaagag gggattccat catccgatag agtagatggg cttctgccct
     6361 cataatagcc gataactgct tggtgacagg catggtgatt ggcgtcggtc tggaaattct
     6421 ttccatgcga ttctgccttt gcacctgacg actctcatta acaatctgct caatctgggt
     6481 ataatcaaag gacgccagac tgtcagctaa aatatgaata tagctgtttt gagcagcgat
     6541 ggacttttct tgaacaatca agggagctat tttttcaaga aactcaatct gagcctgcag
     6601 attttcactg ttttcaggtt tgtactgatg aatgtagaac tcaatcggac taatacgagt
     6661 tttcgttaat agataggcca agtcttctgg accatttttt tgtagatact catcaggatc
     6721 caagttatca ggcatgctaa cgatttgcac aggcatatca ccaatttcat ccaatgcttt
     6781 caatgtcgcg gcttgcccag ccttatctcc atcgtaaaca agaaccaatt tcttggttaa
     6841 ccttttcaga tgctcaacat gctctcgact caaggccgtt cccatcgacg ccacagcatt
     6901 ttcgattcca gcccgatagg ctgcaataac atccatgaat ccttccatca ggtaaatctc
     6961 actagctttt ccagaagatc tttttgccct atccatatga tataattcgt aacttttgtt
     7021 aaaaattgca gtcgatcggc tgtttttata cttagaagtt tgtgaatccg ttttttgcca
     7081 gatacgacct gagaaggcaa tgacctttcc ttggtcattt gtcaggggaa acataatgcg
     7141 attgtgaaag gtgtctacaa attgattggc atccgagaga taaaacaggc ctgaatccag
     7201 taaatcctct tcacgatact gatcagacaa acgttgatag agatagtttc gttctggagg
     7261 tgctaaacca atccaaaaat gtttaagcac ttcatctgtc aaaccccgct gataaaggta
     7321 atttctggcc tcttcgccca tagtcgttgt catgagaata gcatggtaaa atttggctgc
     7381 atcttcgtgc atatcataaa gatcttggtg aggtgaggct gacttttgct cactataaag
     7441 cggtttttca acctcaattc caacacgctg acctaagatt tggactgcct ctataaaggg
     7501 aaccccttgg tactcctcta tgaacttaaa gacatcacct gagcgaccac aaccgaaaca
     7561 gtgataaaac tgcttatcct ctacaacgtt gaaagaaggt gttttttcac catgaaaagg
     7621 acagagccct agatagttcc gtcctgcctt ttgtaaagaa atcacatctc ctatgacttc
     7681 cacaatgttg gcattgtttt tgatttcttc aatgacttgt ttgtcaacca tacacaatac
     7741 ctccatgtta tcatagttta ctttatatag tatactttat ttcagaaaaa aagtaaacca
     7801 tttcactcat tttccttact ttattcaaag agttgataat aatcagagat tttcattttt
     7861 gctttttctt cttggtttaa atcttggata atccgtcctt ctttcatgac aatcaagcga
     7921 ttgccgtatt tgagagcatc ttccatatga tgagtaatca taagggctgt tagctgatct
     7981 ttcttaacaa attcatctgt caattccatc aaagcaacac tagtctttgg atccagggca
     8041 gcagtatgct cgtctaacaa gagtaattca ggtcgcttca aggttgccat caagagactc
     8101 aaagcctgtc tttgtccacc tgataagaac tcaatcggtg tattcaagtg tttctcaaga
     8161 ccatttccta ctttttcaat ggttgcctga aattcatcct tatagctagt caagcgtctt
     8221 ggtaacaatc cacgcttttc accacgaaac ttggcgatta aaagattttc agcgaccgtc
     8281 atacggggag ctgtccccat ctttggatct tggaagacac gagacaggta cttggcacgc
     8341 ttctcgggtg aaaacttagt gagatcttca cctaaaatac ggatagttcc actagttagt
     8401 gataaggtcc ctgctatagt gttaaagagg gttgattttc cagcaccatt tccgcccaaa
     8461 atcgtgataa agtcccgttc aaaaatttct aaggaaacat catttaaaat aatcttttct
     8521 tcatcaaagc catttttaac gattttggtt gcatttttta attctacaat tgctgtcatt
     8581 tgcctaactt ggctcctttc aagattgttt gcttaaatgt tggaatcatg aggcagactg
     8641 ctaaaatcaa ggcactgtat aaacgaaggt aacttgtatt aaagccaagt gcgataactg
     8701 cccacactaa aaattgataa gcgatagaac ctacaacgat agtaaccaaa cgctctgcca
     8761 agctcaaact cttgaaaata acttctccaa taatcaaact tgcaagcccc acaacgataa
     8821 ccccgatccc tcgagacaca tcggcataac cttcttgctg agcaatgagg gcacctgcaa
     8881 gggcaatcac accatttgat aagaccaagc ccatgagctc catgcgtcca gtatgaatcc
     8941 cgaaacttct agccatatca ggattatccc ctgtagcaat ataggcttgt ccgagtttag
     9001 tgtccaagaa aaagagcatg agagcaataa caatgctcac aaagatgaga cctgtcaaga
     9061 gttgattcaa atccgaatca aaaggcaaaa catcctgaat ttgcttggtt ccaagcaggc
     9121 ctaaattcgc acgtcccata atcaagagca tgattgagtg acaagaagtc atcaccaaaa
     9181 tccctgagag caaggttggg atcttccctt ttgtataaag aaggcctgct gccattccag
     9241 ccaaacaacc tgctcctaca gcaacaagtg tcgctaaaaa tgggttcacg cctttggtta
     9301 tcaaagtgac agcaacagct cccccaagag ggaaggaacc ttctgtcgtc atatctggaa
     9361 agtttaaaat cctaaatgtc ataaagattc ccagacctag aatagcccag acaaatcctt
     9421 gagaaataat ggaaacaatc atattttatt taatcctttc tatattcatc tttttaaaaa
     9481 atgggaagag tctcctcctc cctaccttat ttattcgatg acttgtcctg cttctttgag
     9541 aacagactca ggaatagtaa tacctagttc ttgtgctatt tttttattga tgactgactt
     9601 accaattgaa aagacattga ctggggtatc ggctggtttt gcacctttca agacttgcac
     9661 aatcatttta cctgttgcca caccaaggtc atgttggtca attacaactg atgccaaacc
     9721 acctacttct accatagctg tcgcactggg ataaattggt ttcttagaac tttgattgct
     9781 agagacaacc gttggaaatc ctgatgcaat ggtgttatca attggaaccc aaatagcatc
     9841 taccttgcta gtcataacag tgacagttga ggcaatttca tttgttgaag gaactgcaaa
     9901 tgtttccact gtcagacctg ctttttcagc ataagcctta aattcttcga cctgtgtttt
     9961 tgaattgtct tcgctacttg agtaaagagc tccgattgtt ttcacattcg gtgtcagagc
    10021 cttgatgagt tcaacttgtt gttgagctgg attgtggtca gatacccctg taacgttgcc
    10081 acctggtttt ttcaaatctt taaccaagtt agcaccaatt gggtctgtaa tagcggccat
    10141 gataaccggt aggtcttttg ttgcactagc caacccttgg gctgctggtg ttgcgatacc
    10201 aaccacaagg tcatttccat ttgcaaccaa ttgtttactc attgtcgcaa ccttactttg
    10261 gtcaccttct gagttcataa aatcaatttt aacttgatca tctttatatc cttcttctgc
    10321 aagtccatct tggatccctt tataaatcaa atcaagggat ggatggctca caaattgaag
    10381 cacaccaatc ttggttattt tcttctcatc cttattattc tgaacttctg atttattcat
    10441 tgaagaataa atcaagtttc ctgctactaa gactgctaat gcagcaataa ttccaattaa
    10501 acgtttattt ttcattctgt ttctcctttt tatttccttt aacatatttc acttatctaa
    10561 acaagcgacg ccatcgtttt ctttccatac taacctccat caaaaaaatc ctcacacaaa
    10621 aaacttgtgt gaggacgtcg atgcgcggta ccacctcaat tatagggaat ttccctatcg
    10681 ctcagtctcg caataacgag atgcactgta aggtgtgctt accgaatttt tataatttca
    10741 aattctaaat agcattcagc ccaattttca tcatcgccac ttatctgttt tcagctacca
    10801 cagactctct aaaaagtttg tatgattact tttctgaatg gttaaattat atcattttta
    10861 aactacttgt caatagtcta ttagaatttt tttgatattc acttttagca ttcactcttg
    10921 aaaattatca acctgaatta cgcaatcctg tcgcaattcc gttgatggtg atatgaatca
    10981 atcgttcttg atcactggac aattctccac gacgttggcg tttaatcaac tctaactgaa
    11041 tatagttgag aatattaaag taaggcatac ggtaatccag actagctttt agatatggat
    11101 tgtcagctaa gagttcgtca tgtccttcaa tagccaagat aacgttctta gtaacttgcc
    11161 attcatttaa aatagtctca tagatggcct taacttgctc gtcttcacaa agtttagcat
    11221 attcaaaagc aatattcata tttgattttg acaaaaccat atcaacattt gaaagaagcg
    11281 attggaagaa aggccaattt tggtacatat ctcgtaagat agcaatattc tctggatttt
    11341 tattgataaa ttccttgaag cttgaaccaa ccccgtacca tccagggaac ataacacgac
    11401 tctgtgacca tgagaatacc caagggatgg cacgcaaacc accgatttca gtaatagtct
    11461 tacgagcggc tggacgagaa ccaatattaa aacttgaaat agccttgatt ggacttgact
    11521 cgaagaaata atcatagaaa tgctcattac caaagaccaa atcacggtag atatcgtaac
    11581 tacggtccac tacttgatcc ataatggctt cataacgatt tggggtattg gtatcgctct
    11641 tcttctgagt aatcatacgg ttaatagctg ccgatactag catttcaagg ttatagtaag
    11701 cggcgtcttt gttaccgtat ttattcccaa ttacttcacc ctgctccgtc aagcggatac
    11761 gatccttgat agacttgagc ggttgagatg taatggcttc ataggttggc ccaccaccac
    11821 gaccgacagt accaccacga ccatggaaga aggtaacctt aacgccaaat tcatctccaa
    11881 tagcagtcaa ttgttgttga gccttgtaga gggtccaaca tgatgacagg taaccgccat
    11941 ctttattact gtcagagtag ccaagcatga tttcttggta gttatttcgt gagtcaatcc
    12001 attttttggc aaggctaaga gaaagatatt ttctcattgt ttcctctgaa tgatccaagt
    12061 cttcaattgt ttcaaaaagg ggaacaatct gaacacgcgc cctttccgta tccaccagtc
    12121 ctacttcttt taacagaata gctaattcta gcatatcaga aaggctggtt gcatgtgaaa
    12181 tgatggtctg acggatgaca tcatctccca acttatcttt caaaacacga gccgtcttaa
    12241 aaatagctaa ttcttttgct aataattctg atttttctgc gtgagtcgca gaaagaattc
    12301 ggggatcttc ttctaattct ttcaagagaa ggtcacactt ttcttcttcg ctcaactcgc
    12361 tataacgaga atgaattcct gctgatttca agagttctgc cacacaggct tcatagacgc
    12421 tagagtcttg tcgcatatca attgacgcta agtaaaaacc aaatatctct actgcctgca
    12481 ataattccac aaaatcacct gaaatcaagg actcaccctt attttctagt agagaatctc
    12541 gaatggcaat caaatccttg tagaaatcat tggcggtttc ataacgagtc ccaacttctt
    12601 catcctcaat cagataggtt ttagttgcct gaatttttga ttgaatatca aacaaggcac
    12661 gacggtaaag ctctttttcg cggtaaatcg agttatcctt ggattgacga gccatttctc
    12721 tgacttgctt gctgacgttg acaatgctag ttgaaagaga aaattcacga taaagttggt
    12781 aaatcttttt atcatagtag ttcatgatga cttcacactg agtgagtgca gactgcttca
    12841 aggtctttgc tgtaacaaat ggatttccat cacggtcacc acctatccac atacccatgg
    12901 tgattggttt agcctgtttt aaattcagac catgcgcttg cgctaagcgc ttatactccg
    12961 tcgtcaaatg aggtacagct ttcaaaaagg agctgttata atattccata gcattcgtga
    13021 tttcgttagt cacttttaat tttttctcac gaatcatgtc tgtctgcatg ataatttcga
    13081 tgtaacgacg caaatcattg taccatttat ctttattaat caaccccaac ttaacatcac
    13141 ggtatttacg caaaagacta tgaatatgat ttgttaaatc caacatactt ttgcgttgca
    13201 cttgtgttgg atgggctgtc aaaacaggga caacattcaa gtgttctagg atctcaacgg
    13261 cattttcctt ttctgctacc aatttaatcg ttgtagataa tttacctaaa tagtcctgat
    13321 caatattatt ttgatgattg atttcataag ctaaatccac atcctctgaa atattaatca
    13381 aaagaggcaa gatagagaaa tagcgtgaaa tatagaccat ttcatcattt gataagctag
    13441 tcactagacg gtttagacct tgataatctt cctgcgttga taattctttc aactgtatta
    13501 ttttttcaaa ggtctctggg gcaagcatat ttttagtaat atcttccagt aattctgtta
    13561 gaatcaagac ttcttcttgc acaacacttt tattactata attttctaat ttttgaagag
    13621 acataaacta tcctttcttt atcctacttc aacagaaggt tcattggttg attttccaat
    13681 tctcggtaca atttagcgcg tttttcactg gcatcaatat ttaagacaaa ggctactgcc
    13741 actgataaga ctagaagact atttccaccc tgggataaga aggggaaggt tactcctgta
    13801 gatggaatca agcccgaaat ccctccgata ttgacaaata cctgaaccaa catcatccct
    13861 ccgacaccga gtgcaaccat ggcattgaaa ggattctccg ctcggatacc gaccaagata
    13921 atccgcaaaa tcatgaaaaa taagagagct aaaataagac tggcaccaac aaagccaaat
    13981 tcttcaatca cgatagaaaa gacaaagtct gtatgagctt ctggcaaata acctcgtttt
    14041 tcaatcgagt ttccaagacc tagaccaaac caaccgccat tgaccatggc aaaataagaa
    14101 ttagctaact ggtgacctgc atcagcacga tcggcaaaag gattaaaaaa ggcactaaag
    14161 cgcttggcta catagccaaa tactggaatt tttgaaaagg tctcaacacc gattaggctg
    14221 atagtggtca agacaaagac agaagcggca gatacgagcg ccagaatggt tgaaaaccag
    14281 cgataagcga ttccactaac tgtatacata atcaaggaaa ccaagactaa aatagtcgca
    14341 tttcctaaat cagggaaaat tcccaaactt ccaatcagaa ctaggagaac gaatcgccaa
    14401 tcattaaaag cacggggaag ccattgattt tgagtcaaaa cttgaaaatc ataagtagct
    14461 atttcttctt gctgtttgga gaatcggtga gctaaatacc aaataataat gatttttaag
    14521 tactcagctg gctgaatagt tattcctgca accgaaatcc aaccgtatgc cccgtttacg
    14581 gaaataccaa taaaacgagc caagaacaat aaaagcattt ctattaatat aactaaaatg
    14641 attagtcgct catttctcaa aaaatctagt ctcaatttat aaattaaggc aatcagtatc
    14701 aaactaacaa tccaaaagat tccttggttt cgaaccaact gcaaggcgct cttgccttct
    14761 tcaattaaaa tagcactggt ggtcgaatag accacaatca agcccaaaat agataaaagc
    14821 aagtagggaa tcaagatgga ataatttaat aagtgcctct tactaatctt catagtatca
    14881 ccactctact aggatacaga caaatctgtt ccaaattccg ttttattttc tagttttgat
    14941 tgctattata ccattttttc agaaagaaaa aaactcttac cttacaatcc ttcgaatttt
    15001 actgttttta cagaattaag gcagaatttg aaatcgtaaa accattttga ataagagttg
    15061 cttcaatcca ttgactccga ctaattatgt tgctttcgtg aatgccaaaa tcagccgcaa
    15121 tttgttcata agtgtgctat tctcgcatgt attgaatagt taccatgagg agatcgtcta
    15181 ggcttaattt ggtttttcgt ccaccttttg cgcgtttacg ttgcgttgat aagctgtttt
    15241 taacacagct aacatctcgt gcgctgaaca cctacaaggc tcttgaaacg gctatcgctt
    15301 aattgtttac ttgcttcatc atccatagtt ttattgtatt gtatttttgt ttcgcaggaa
    15361 gtctattatt cctttcgttc caaggttttt acgcttttag caacaagctt acacactcca
    15421 cgtgatgcgt ctgtggaact caaaaggttc ggggaacctt ttgaggatta attgcgtttc
    15481 tctaacaaac tcacacattt aacgtggcat gactgatgaa gtcatcataa gaatttcact
    15541 tgctgctctt ttacgatggc agcctgaacg gtcagaagta tcattgtata tcatttgtat
    15601 catggcatat aaagtatcgc tctattttat tgatggtttt aatatctctc ggaaaagtta
    15661 ttcttgatta attatagaaa catttggatt gccagtttta gaagcaccaa ttatcttaac
    15721 ttttaaagct tcgtacaaac taattctatt ttctagaata taagctaatt cttgtccatc
    15781 cataaataaa attttagcat ctttattaga aaaatcttgt attacttcat ctctaaaacc
    15841 atttattgaa agaaacagtc cccgagtcga agttagtttt gtatcaactt tttgttttaa
    15901 agaagctatt ttcggagaat ttactggatt tttttcccat ttcatttcaa ctaaataatc
    15961 aaaaccttca aacctaaaat agccatctaa ctgttgagta tttgttctat ttctatacga
    16021 atcatggtaa tcaatatcat taattctgaa taaattagca acaatttttt ctaaacgata
    16081 tcctctttct tgaggattat cacttgaaaa tagcgaataa tactccgtct ttagttcttc
    16141 aattttttga aggagttgtt gcctgagttg tattttcatt tcctgtctgg aacgatgata
    16201 agaattatta agtgtttcgt taaccttatt ctgttgagta tcacctatca gtcgctttaa
    16261 ttttcttaac gcatctaatc ctctatctct atcttgaact tcatcaggaa tatttttcat
    16321 cttataaaat tcagttgcta ttcgtctaat tatcaatctt ccattttctg ttttattaag
    16381 ttcatttata acatttttcg cccaaacaaa cttcggttcc gatttccatt ttaatattaa
    16441 atcatttgga actcccgaag tttgcataaa tgaaacgaca gtatctttat agtgaaaaca
    16501 taatccaaaa cattgaataa tttgttgttg gatttcaaaa gatattttag tcattttttc
    16561 tcctttttat caacaatatt acatttcatt aattatctgt gtataataac ttggaaaatc
    16621 actcaattta tcttctagtc tagctgattt ctgtttgatt tcatttctaa tttgattctt
    16681 acttacagaa ttaatctctt gaccaataac ttggaccaca attctatctg aaaaacctaa
    16741 ttcatagata ttgatttctt tttccagagg tagcccatat ttcagcctct ttattaacat
    16801 agtcaatacg tccaattcct ctccaactag tttttcaaga atattattaa tcgcatttaa
    16861 aaccattgat gtttcatacc ctaatccatt atcacaaata gagattatgt cagacatatc
    16921 aattggtttt gacttacctc ttttctcaat actaattgat ttttcagtac aactttccaa
    16981 tatttgaaaa taagaaatcc ccttaatcca gagttgagaa atataattta gattttctat
    17041 acttagtttt ctcatctctt tgttatttga aaaatctatt attttcttgg ttaaaacacc
    17101 taataactct tcttccttct cacaagaaag gatagatgtt ttattttcct gaacccattc
    17161 ttttaataac tcagattgat ataatccaat tgagtttttt gcaattattt cagtttctac
    17221 tgaactggta attattttag attttatcaa gataaataat tcttttattt tttctttttc
    17281 ctcttcatta cctaagaaat atccaaatgt attttcagct aaactatcag tctccaattc
    17341 agtagcatac atagaagcaa tataattttc aattgcaatt agggtattat caatctggtc
    17401 tatcttagaa ttaaaatcct taaaataaag actgttcttt ctttttaatt ttgataaaat
    17461 attatttatt tttgttctgt agtctacaga actgtcaaat ctctctttaa tcaaattcca
    17521 aaaatcaaat tttataggag cgaatcgata atcagttgga actactgatt taaactgtat
    17581 aatactgaga atattacttt gacaaccctc tgtattaata ggatttaaca atgctttata
    17641 gttttgtttt ttccacttat tttttggtga tttataaata ttgggctctg ttaaaattat
    17701 tgttccttct gtatattttc cagcccttcc tgctctacct atcaaattct gaaaatcacg
    17761 aacttttatt gcatctcctg cttgatacac acttgagata atcaagtatt taataggtaa
    17821 gtttatacct tgtgctaagg ttgaagtaca tactacatta tttattttac tttttgaaaa
    17881 agcatactct atagcaatgc gtatccccat aggtatacct gaatgatgtg aaaaaactcc
    17941 tagctgacta catgtatatt caacactatc atatcctaaa ttttgaccaa ttaaatttcc
    18001 tattttttca acttcagacc tatctgagtt ttttaagaaa tcagttagat cataatttct
    18061 attatttaag tctataaatc ttcgtaaaat aacattgacc gtgtcttttc ttccacaaaa
    18121 aattcctact ccaccattat taattagctt agtcccataa taaatactta tatcatttgc
    18181 gtttgtcagt tctggaaaaa ctttttgttt gcgttctttt ccaagctgct ctaattcact
    18241 aacactaaca gtacgtggaa caaaaaattc ttcttcaaat gtaataggat ctatgaaata
    18301 taattgctca ttactcccgt ttaaatcact aaacgcaact cttttctctg ttgttttaat
    18361 cgaattatta gaaacaatta ctccatcttc gttaaaccac cgatttatag cttcactatt
    18421 tggtattaca gcagatatta aaatcttctg tattcctttt gggaaaattt gtttaaccgt
    18481 tgacaacagt aattcaaaat tggttccacg acttggatca tcaaaaagat gtgcttcatc
    18541 aaatatacaa agtcctattt catcaataaa actttgatga tttctcaata aaaacaacaa
    18601 tttctctgga gtaagtataa aaactctttt tttaccatca ttaaaaattg agaaatcctg
    18661 tggaatctcc ggtaaatcaa aaacttcact aacaatcaca ttattctcat caacgaaatg
    18721 tgcattaata tctcgatata tttctctaca taatgctcta aaaggtgcaa caatcaatgc
    18781 attatcaatt ctatttgaat aaaatgctga tcttaaagtt agattgattg aggctgtttt
    18841 acccgaactt gttggcatct gaacgattcc agatttacct gaaaaaattc cttgcttccc
    18901 taattcgatt tgagatggcc aaagctcctt tatgcttcct gttgattgta tataatcctg
    18961 ccataaagaa aaatctaatc ctgaaaattc aggtaataat ttcgttgatg aactatttat
    19021 ttttttacat acaactgcta agagacaatt tacaataatt acagaaaaat cgcttccatt
    19081 cctatatact ttatcttgta aatctctata aatatctata gaaaactcag tttttgataa
    19141 aatataattt ctatatgatt caactagagt atttaactca ctagagtatt taccttctat
    19201 tggcgtatga ttcaaaaaga gttcatccgt tacaacgtca ataaatactt ttataagagt
    19261 catacagtct tctaataact ggatatcatc cgatatatag ttaatcataa ctctcgaact
    19321 accattataa tcgcatagat aataagctgt ggtacccaat attgcaatat agtcttgata
    19381 ttcagctgaa tttcctaatc ctgacaccag caatgcatca aaatattcag cagcattgtg
    19441 taattgattt tttaattgta aattaaaact cttacgattg atataaactt caaaatactt
    19501 cctagcagta tctgcaacaa ttgctagtgc cccaagaaac gatttttgag catcctctga
    19561 aattggtaaa tgactttcta aaggaatatc aaattcaatc atctttgcct ttgaacgcac
    19621 taattttgaa aaatataatg accttctccc aaattctatc atacctcact cgctttcgaa
    19681 tagagttctc taataaattt cattaattca ttagaatgaa tgaccaatag tcgtaatttc
    19741 tgaaaatctc tgtgattttt tgaaactact gtcttgataa catcaatatc atatgattga
    19801 ttggagtaga ctgcaacagc tccatagatt acattaaacg gtttatccgt tatgtttaaa
    19861 aatctttcta ctacatttgc ttgatcacta ttagatttct ttaacctcaa atagctggct
    19921 acaattgagg ttgaaaatcg ttcaaaatct ttatcagaat gattaatagc ttcttgaagc
    19981 ttatttttcg ctttagagct actagaatct gatgcagatg attttacttc aataactaca
    20041 acctcatcat tcgacacatt cgaagaatct tgcttatatc ctagaacatc acttccttga
    20101 gttgaagtat ttttattgac tttactatca taacgagtcc taggaaccac atattcttca
    20161 atatactgaa gataatcaga tactaatatt tctccaaaat ctcctgacat cgttgaaagg
    20221 ccaataccac tatccgaggg taatttaaaa ttttcaagat actctttagg ggagatattc
    20281 ataaaaccta tcatttcagc aagttcatca tcagaacaat aatttcttct gaattgtttt
    20341 gcccaatctt caaaaatttc tgggtcatct tgaatatcta agtgaagaat ctcaatctgc
    20401 ttaccttcat cagtaataat aggatcttct tgagttagat actttatata actatgcatc
    20461 ttttccatta cttttactca tatccctcat ccgttcttct cccaccttca acatctcttc
    20521 ctctaccttg ctccattttc cgaagaggta ttcttgtagc acttctgctg ctgaagttgt
    20581 attttctttt gaatcatata cacaacttct atctcgttgg taaatttgaa ttctttcaaa
    20641 aatagctagt tcttccaatt gtcgtgtatt atcaactaga tgatttacaa tgaaatcatg
    20701 atgttctttt ggagttgcgc gtgctggatt tggattgata gcatacagtt cttcgtatcg
    20761 gataagggtg ctcagatagg acaattcggg cttggttgca attaaggcta attgtacctc
    20821 atacccctta ttttttaata gttgtgctgt tttctttgga acatcaatag ttcgtaaagt
    20881 tccctctatc aaaagattgt atcccaaatg actcaattcg gttactaaag actctaccat
    20941 tttccctgca aaatctttgg tgtattcaac gctatctttg ccattttctt gctgcagttc
    21001 taaatagtgt ggatgctgag aacgaaaact atcaccatct atgataacaa tatttccttg
    21061 aaattctttc tgtttaatac gatgaattgt agtcttaccg gcaccacttt gacctccaag
    21121 caaaatcgct atagattgtt tactggactt ttttcctctt gtcagtgaac gaagattcct
    21181 tgctaaagca tgtttgaatt cactatcagt ataatcttgg atttccatta agctaccatc
    21241 cgcttttcag atatctctaa catacgttca attccatcca aatagccgct atatctctct
    21301 atttcatcaa aattttctac taaatagata tttgtctgaa tcaagtcaga tagatcatca
    21361 ctcattaaaa tccaaggatt agattcatca tcaatgctaa ttccctgact atcttgataa
    21421 cgatagagtc gagataatag attagcacct ctttctttca caatttcaat tttcaaagtc
    21481 aattcataat cttcaacagg attgagcatt ttatcttctc ctacaatatc gacataagat
    21541 acattaaact tctgacaaat gatgtcaatt aattccgtag agactgaact agttccattt
    21601 tcataacgac tcaagctatt tcgagaaatt cctataattc gtgcaaattc gtgttgtgtt
    21661 aagtcatgtg ttttacgtaa ggattttatg ttttttccaa tcatggcaaa ctcctttatt
    21721 tttataaatc cattatagca taaaaaagca taacgcacca aaaatggtgc gttattgact
    21781 gtttttctat cctaaacttt acttctataa aagtcaccta aagagccata aatatttatt
    21841 cttgtattaa ttttttcgat gcgcaaacga tatctacaaa tacatctata acgattcacc
    21901 ttttaggatt tttattgtca aaattgcctt tatctacaaa gacaaaatgc ttataaaata
    21961 gcttgaaatc aaggattatc acctttttcg ttgtagcaac actccacatg tgattattag
    22021 gctattagca aagcgtatcc aatacctcaa taaagtgttg tttttactga tattttaact
    22081 atattgtata gtctactatt taaatctcaa ttaggatatt ttatagaata cccaaaattc
    22141 aacaataact aaaagtaaga ttccattgta tttccttgtt ggtctttcat atcacgaatt
    22201 ttatttttca gaatattaaa gttacaaatt tcatctctaa tatcgttatc cgctctgtag
    22261 ccattaatca tctcagtcag agttttccct ttactaccat tctttatagt agtatttact
    22321 ctttttatac tgctttcaaa aggctcatat gttttatact taattacttc gtctttaaaa
    22381 ttaaataaag gtgtatccgg cttagcattc cataaaataa tcaaccacat tataacatta
    22441 taaagctgct ttgcattttc attccacttt tcaggttgta aatttccact ccctgtattg
    22501 tcatattctt gtctattatt tacatgagaa tcacctacaa gcggattaaa aagaggtagc
    22561 cctttgtgat taattagttc taaaaaatcc cttgccgcac ccatgcaaca ctgaataact
    22621 tccttcttgc catcaatttt actctcagcg ataaatacat aatattcatc ttcaatagtt
    22681 gctcctgcat cactatgttt ttgttgattt gctaacagct taatatgtgc tttaggctaa
    22741 acttcaaaat ctctaacaat tctttgtctt gtttcatgtc ctctacaatt catttaagtt
    22801 ctcctttaca agtttagtaa ctagccttat tatactatat aagatatgaa atgtaccata
    22861 atcttcatca actagttttt agaaaatcac aaatccatct ggagagatga caagctgatt
    22921 ctccaattct tggcaattgc ttgctagtac tactgcttct ttctctaaaa gataatcttc
    22981 tgttgattgg ttgaatattg ctttgaggat ccgtccttcg tatttccatt ccagatctac
    23041 tagatcagat ttgatttctt gaaggctata cttgccatgc gaaatgatta ctgacgcgta
    23101 tttccgaatc ttaatcagcc tcttcataaa gttcagcata tcattgtcac ttgatacacg
    23161 ttcccaaggc atacaacgac gacaatctgg atctggtcct ccagtcaagg ctagctcggt
    23221 tccgtaataa atgcacggtg ttcctttttg taaaaagaga aaggctaagg ctgatttaac
    23281 cagttgaaca tcttcattgg ccgtccacag gattcgctct gtatcatgtg aatccaagag
    23341 attaaacatg acctctgaaa tctgctgctt gtaatacata gactctccat tgatttcatc
    23401 gatgaactgg tctgtattct taattcctcg taagaaatag tccttgatac tatcagataa
    23461 aggataattc atgacggcat ggaactcatc tccatttagc caaggctgag atgtatgcca
    23521 gacttctcct aggatataaa gatcaggatt tttagctaaa actgccttac gaaaatcctt
    23581 ccagaactga tggtcaatct cattagccac atccaaacgc caagcatcga tattaaactc
    23641 ttcaatccaa taagtcgcaa cctttaaaag ataattcttg acctctggat tggctgtatt
    23701 tagcttaggc atatagtcct cgaaaccaaa aacatgatag ggtaagtctc tcttattaac
    23761 tagcttttca gttgtcactg ggaattgttg aatatggaac caatccttat aagcagactg
    23821 ttcaccattt ttgacgacat tttttcattg aagagattgc gaaccaatat gattaaatac
    23881 cgcatccagc atgactttca tgccacgatg atgcgcttga tccaccagtt cccgaaaggt
    23941 ctccttgtct ccaaaatgac ggtcaatttc aaagtaatct gtcgtattgt acttgtgatt
    24001 gcttgtagat tcaaagatgg gacaaagata tagtccagta atacccaagt cttgcaagta
    24061 atccatatga tcaataatcc cctgtaaatc accaccaaag aaatcatcac tcttaggtgt
    24121 gacagatgaa tcccagtcta aagtcccttc tgggtttaat agagcattgc cattggcaaa
    24181 tctttcagga aatatctgat accataccgt atttgaaacc ccgtcaggaa ccttgcaggc
    24241 atcaatctca tgaagataag gcaacttaaa tccattccca attgcatgaa gattttctag
    24301 agaattttcc acacaccctt tatcgccata caaaatattt tgaccttctg tatctctgag
    24361 ctcaaagaga tactggatac gtgcaaagtc aactgacact tcaacctgcc aatggtcaaa
    24421 taaggtacca gaagttatct tgaccatttc ttttgtatcc tgataaaact cctccataaa
    24481 gataaaaggg tccccatagt gcaagttgat gctttcaatg tcccctttct tagttcgaat
    24541 tcgaatatgg agtttcttat ccttataaag ataggcatac tccgactcag gcccatggta
    24601 aatagcactt aattccatca atttgtctcc taaagtattc attcaaattt tacgcaaacg
    24661 ttttcaaact caataaatcc agtatactat ttttgtaaac tatttgcaag gaatgtccgt
    24721 tgttaaagga actatctttt aaagtataca aaaagcctta aaaaaggctt tctctatata
    24781 ctaatcctct ttcggttttg aaaatacttc tactcgctga gctaggactt tgatttctac
    24841 aggtaggtta tctgatttat ctccgtcaac atctgactcc aattcactat ctgaagagat
    24901 tttaatatta cgcgctttga tatactcgat attatcattt gcgataacat ccccttttaa
    24961 taaatcagga atgacggata atttggagaa tatagaggca tctttcagaa tcaaaatgtt
    25021 ggcatagccg tccttgtttt cttcaaagat tttcttatca gcgaagtaat ttgtcaaaag
    25081 gaccaaaaca tggctagctt caccaacata atttccattt tctgtctcaa ccttaatgtt
    25141 aaagacctga tctgtcatga cagacttcat ggtatttaca gcataggtta aaataccgaa
    25201 ttttgttttg tcctctattt caacattgtg aatcgcctca ggcagagaac cgatactaaa
    25261 gatataacca aaatagttgt catttgcttt accgatatca atcttattgg ttaaatcaaa
    25321 atccagttcg tcaattgcgc catcgatgtc ttgattgatt tccaaaagtt ttgtaatgag
    25381 gttacccgta ccgcctggga taatccctaa cttaggaatg tagtctctct catcaatacc
    25441 tgaaatgact tcattgacag ttccatctcc accaaacaca accactgcat catactgctc
    25501 acgagaagct tcttcagcaa aatgtgttgc atccagcgct ttttcggtaa ttttggtttc
    25561 aacatattca aagtattctt ttgctttatt ctccagcttt tctttgtaat ccaaagcctt
    25621 ctcgccacca gaagtagggt tgataattac cattgctttt ttcattgatt ttatccttaa
    25681 ttttaaacag aaatgtttac atttcgtcgt atgcaagtaa atgtaatcct attatacaat
    25741 gaaaatacag aaaagagaaa tctgacgtac tggagattaa tacgctttta ttctattttc
    25801 ccatcgccta actacatcct ttaagggttc atccaagtaa gaataggcct tatccttgat
    25861 ccaatcagga ataccgtaag ttgcctctgc tatgctacaa gtgattgctg cgagagtatc
    25921 actgtcgcca ccaagtgaga tggcatttct tatcgcatct tcgaagtctc tactttcaag
    25981 aaaggcgata atggcttgag ggacagtttc ctgacatgtt tcgttaaaac gatagttagg
    26041 acggatttca tctaaagttt gagatagatt gtaatcgtat tctttttcta tataatcctt
    26101 aattcgtctt ttacactctg taggattgtc gttaattgat tgctcgtact ctctacaata
    26161 accaccaaag taaaaacgac atagaaagat agcatcagct gtagccatag cgcctttgac
    26221 accttctgga tgattatgag ttacctctgc agaaagactc gtaagtcctc tagatgatgg
    26281 ccacatacca gttttcgcat aaaaaccaca gtccatgatc caagcacatg gagaaatacg
    26341 catagctgat ccattcccaa agctattata aggttcacgg ttatcgctgt ttagccatgc
    26401 attaaaccga gcaccgtaat cagcattcgg atacattctg ccatatttct tcatcgcgtc
    26461 aatgaaatcg tctttttgtc caccattcat aattgcttct gcaacagcac aggtcataac
    26521 cgtgtcatct gtaaaaaagc agtccttccg aaataaagga aagtcctttg ttttgatatt
    26581 gttccattcg taaacagaac cgacaatatc tccaataatt gctccaagca tcagattcct
    26641 ccttgttcat tttgatgctt tttatattgg ttatctacca tatttatttt agaaaataac
    26701 atcctgttgg attttaaaaa tttcattttt ttcaaaatag ggttttacca tttctttcca
    26761 cctagctcta tgaaaattga ttgattttaa aggagatagg ccataatttc ccaatgcata
    26821 accatcattt acttcaacaa caagtgttct gccatcgcga gtaacaccga tatctagtcc
    26881 ataagctatt ggcgcatctt tccaacatga tatcgcttca tcaattacac ttgcatcaaa
    26941 ttgtgcatga taatcacctg tatagggtcg aacatctaat acgcgaacat ctaacacaaa
    27001 acaacgccat tcagctatga attctacaac ctcactaatc catataggat agtcgaaagg
    27061 tagaccaata cctattaaat catgggttcc attaacaact cttccagtaa agacttttga
    27121 accagcttta ggcttaataa attttcccca attatcaggt atattcacaa tctctcctaa
    27181 aataccagca taaatctttc gaccataaaa ctctttaagc tcaataggat agtcataaac
    27241 cggaacgttt aagcccatca tttttagtaa tgctctagtc tccattatat aatctacaac
    27301 tatatcttca cttgttaact cttttatttc agaaaaagat tgatataaaa taacttcttc
    27361 tccttgtaag taggcaccta cttgagcatt gtatttatta attgaaacct cacttggtaa
    27421 tttactttgt ctaatataaa caaccatttc atcactccta tatcactagt gttacaccaa
    27481 tttgtaaaaa taatagcaat tttgctctta tttttttgag taaatagccc ccataatatc
    27541 atcgaaataa tcaacggtat ttaggagtaa ttcaataacc tgggactttg ttagtcgcat
    27601 tccccttcta tctctagcat cttctactaa attttcaagt ttctctagat ttttatcatc
    27661 caaactaatc attattctat ttttatcggt tgccattttc atcacctcaa gttaattcta
    27721 tcacaggtgt aacacttgtg tcaactggct tttataatac attagtttaa aagtggagag
    27781 gattttttac acagtaactt taaatctttg gtattaaaaa attttcacaa tatttataga
    27841 aataaaatct gtctcaaatc agttatcaaa tctagtataa attatgagcg gctactctaa
    27901 tactttccct ctaaacaaga aaaagactta cactcaagga ttttcttccc ccccttcgtt
    27961 ataacgtttt gactctttta ctagcaaagg tatatactca caaggaactt tggttgacta
    28021 ttgaatctct ccaacttctt ctttaacata tccttctaca tcttcaatct ctacaaacat
    28081 tgggtctaag tgacacaaga aatgccaaac ttcgatccct ttttttctgt aaagaatcgc
    28141 ttcaccgtct tcacttccga aaaagcttct gtcgatttca tatccgcggc tttctaagaa
    28201 gtcttttgct ttacgatagt tcgtttctct tgtttcgaca taggctttaa cttcatggtt
    28261 gttaacgaca tatgcatcaa tttttgaata tccttcgatc actctatcat ttttgaggga
    28321 taaatttgaa atctctttcc aaataatgtt tacattttcc ccaggatcga acataaattt
    28381 agataaagga acaatatttc cgttaaaaat aatttccata taatccggta tgtttttagg
    28441 attaaaatac tccacttcaa aaccatcttc tgtttccaga gtgtatcccg ggatttgagc
    28501 tacaaaggct ttcccatctt ctatggaatc aaatgctact aaatctttag aataatcatt
    28561 ttggtacaat tccaatataa ccatcgataa tctctccatt ttcattatca ggctaatgta
    28621 aataagcacg tcacctgacc aattcaggct ctctgtatca tctcatcata tttcctactt
    28681 actttacgag tcctataccc agaacacacc ttatcgacct tcggtctcac ctcgtcgcat
    28741 tggctgaaca tctactttta ctttgctgat gcttcaactc gtacaagcag tgataccgcc
    28801 tcagcgtgat gcgtcagtgg gactcaaaag gttcggggaa ccttttgagg attaactacg
    28861 tttctctaat aaacttacac attcaacttg ttcatcattg tccaaaccta tgttgagatt
    28921 ttcttctata attggtagct taaaagtaat ggattttagc cattgtccgt tagattgttt
    28981 ttctttataa acttgaattt cagaaatcaa agctgaaatt aactgcctac gctctacatc
    29041 attcatgact ttatagagct tatcaaaata gatcagaacc ttatatatgt tatctcctgt
    29101 aagcttttca gcttcaatag tctgtttctt tgctttcgca tcaattagtg atgattctaa
    29161 ttcatctatt ttgtcataca tacgatatag tctatcatct aaatcctgtt tccttctctt
    29221 ataatgctta tcttcaacat ctaaattatc tatttcctca attagcttaa actttgtaga
    29281 atgactcttt ctcaattcct tttggtaatt atctatttct ttttctattt cagaggtatc
    29341 caccttcatg ttgatttttt cttgcatcat agaagcaaat ttcggattac ttactatctt
    29401 gacaatcacc tctgcaacag catcatctaa caattcttct ataatttgct tactgaatgt
    29461 acacttatga cctcttatca tctgcctatg tttacaacca tagtaataaa aatctttata
    29521 ctttgtgcca tctttctttt tcttgataca cttgttccca aacattccca ctccacatat
    29581 cgggcatttt acaattccag aaagcaagtg tgtgcgtgta tcttttcctt tattcacatg
    29641 ctcatatttc tttgcttgag attttagctt aacctgagca gcttgccaaa cttcatcgga
    29701 aactatagct tcatgtatcc cttcagatat tagatattca tcttgttcaa cctgcttata
    29761 ttcatttctt gtaccatgaa ctttttctaa agttcttctt ccaaatgcta ttttcccatt
    29821 atatacagga ttctttaata tctttcttat aagacctgca tcaaacaaag gattcttacc
    29881 attctgtctt gggatttttc taattccatg attctctaag tatttagata tcccattggc
    29941 tcctatcgta gtatttacat actggtcgaa aatcgttctt attgcaactg cctcttcctc
    30001 atttataaac agcttgccgt cttcaagttt atatccatac ggagcaaagc caccattcca
    30061 ttttccttcc cttgcttttt gaatgcgacc ttccattgtt tgaatacgga tgttttctct
    30121 ttctatttca gccacagctg ataaaacaga aatcattagt ttcccagcat ctttagatga
    30181 atcaatgcca tcttcaacgc agataagatt aactccataa tcctgcatta tctgaagtgt
    30241 agaaagaaca tcagcggcat ttcttgcaaa tcttgataac ttaaacacaa gaacaaaaga
    30301 tactccatct tttccagatt ttatatcttc catcattcga ttgaactgta ttctaccttc
    30361 aatagacttg tcagacttcc cggcatcttc atactctcca acaatttcat aatcgttgta
    30421 aatagcaaaa gctttcattc gtgatttttg tgcctctaac gaatacccct ctatctgtat
    30481 tgacgtagat actcgtgtat agaggtatac ttttattttt tcttttgaca tagtattaac
    30541 ctcaatataa tttttctata tcatatataa tttttttaat ttaagtttgg actatcattt
    30601 caagtatatt ataacacttt tattagtccg tctcaatttg tgtttttgcc atgtcaaaac
    30661 tatttttcat atcttgattt tttgctggcg ttggatcggg tagattatct aaatctaaag
    30721 caccagcata ttttgcaatc agatttgcta ttaaatcagc caatccattc cagtcattgt
    30781 ccaatatata cctcctctaa agttttatat ctaataatta tttgtttaat taagtttttt
    30841 gacattgaca agtgctttgg attagcaaca taggaatctc acctccgcct ctattccgga
    30901 tgagccggct tcaaccttag aagtatcatt atcctcattt tcttcatagc ggatagggta
    30961 tccctcccta tattcaaact cttacttatc gctcactttc tttttgctta gcagaacttt
    31021 ttttgccgaa ttattcagcc gaaagatctt gacggatagg ttattacgct ccaaaaataa
    31081 ttaacgtctt gtcttggtct attcaattgt taaggttcaa aatttatcga gagttattaa
    31141 tctttttaaa atttgaccat cagaaaatat ttatcttgat gtaacaaaat tctataaatt
    31201 accctcttat acttaacagt gaaaagaagt ctttcttggt aaccaatttt gaaatagaat
    31261 ttgcttatat aaaaaggttc aattcccact gcataagtag cagtgaaaat tagaccctct
    31321 tggtaactgt catctaaaag tcttctagca tttctttaat tttctaatcg cctttaaagt
    31381 gtcatattta tattttttta tctctggcat actttgatac ctttttagac ttaaagtctt
    31441 taatagtgcc tttccacctc tttttatcta taaagattct cctacatcat aattcatttt
    31501 tttatttaaa cctttctgtc ttagtttgtc tttatcttct tcataccatt ttaatattgt
    31561 cacatagtgg ttttgatagg tcttaccact gctttccatg tatctggata gtttatttat
    31621 cattatatct gtgtgtgagt ttaatttttc ttttagattt ttatattctt ctttgcttaa
    31681 ccttacattt ttgaattctc cataaaaaat gggggtggac tttttatcta tctctccctc
    31741 tctctcttta tctatctcta tatctttctc tatctcttgt cggacatggg ttggactcat
    31801 taaggacaat gtcctctgtt tattttgtct gtatcttctt tttttctctg cccaggctgt
    31861 ttctgatccg attaagtttg gtatttcagt taggtagtat tcatcatttt ctgttacaac
    31921 ttctaataag ccttgattga ttaaataatt tactgttacc attacatcat cgtctgtttc
    31981 atctatggtt agtgctaact cttttataaa atcactttct actccgtcat aatagagttt
    32041 gccctcatct tttaggctta gtagtagaag ttttaggtag attatcgtat aggtatctcc
    32101 tccagatatt ctccttaacc tttttatcct tttgtctgtg aaaaattctt cttttaattt
    32161 tatccaatag tatcttttgt ttgttgccat atctgctcct ttcttgattt tcgataatcg
    32221 aaattcttga tttccgattt tcggaattct ggacttctgt ttttcggaag tcttgttatt
    32281 atggttattt aagggtgtaa cttttcgtta ctccctttag atttctctgg tcatatcttt
    32341 tttgtttggt tttacttttt cttttacttt cctttttctt ttgtcttatc tttgtttttg
    32401 gataggtctt tgtatttctt tatttgtttt tggatacttt ctttttcttt tttatttagc
    32461 ctataactat tagactttaa agtttctatt tttgtttgta actgacctat ggtttctatg
    32521 ttgttttttc ttaaataact atatgcactt gttagctttt tgaagtcata tttttcttta
    32581 ttagtttttg catatccttt tagatattta cttttttctt tttgaatttc tgaataagtt
    32641 aatagataat ttgttagatt aaaaagttta gggttgtcta ttaccttatc tctttcgata
    32701 tccttaaatt tttcataagc agtagataag ttatctaata aatttcctat ccaacccttt
    32761 aatgttttta tctcttcttt tattgttttt acaagttgat tatattttct tatttctcta
    32821 ttatagtttc ccttgtcagt ttctattccc tttctttcca ttgcacttgc tgctgatcct
    32881 aaatggattg tcggtagata atctgaattt tgtcttttaa aactcctatg gtctactctt
    32941 ttttctgctc ctgctctttc taaatatttg ttacaaagat ctgaaaaatt ttctctccat
    33001 ttttctacat tgcctgtatc gttccaggtt gttagttcta cttttcttgt ctttggtttt
    33061 ccatttttgt ttaatacttt ttctcctttt tcatctagga tatattcttt ttttgacttg
    33121 gctaagaact ctcctttttc gtttattggt cgcattatgg tcattatatg acaatggata
    33181 tttccatttt tatcttgact ctcatcatga attgcataat ctactatcat tccttgtgat
    33241 gttaaatttt cttttatata tctttcaacc aggtttttat tttcacttaa agataactct
    33301 tttggtagtc ctattatgaa ttgtcttgct agttgtgcat tagaattttt ttctgccatt
    33361 tctactttat tccataaggt agacttatca ttaaattctt ttggtatatg atcaggcaat
    33421 attatatttt ttactaatat tttttctttt cttgtgtagt catgggttac tccgtcccat
    33481 tcatttttta ttttttctcc acttatatat gctgcacttg ctactgcact tttgcctttt
    33541 cctcttgata ttatgtttac tgaaaaatga aaactgtctg ccatttttat cacttccttt
    33601 ctttgttgtt ttaggtggag gcttaatagt ttttttatat cctctttgtg aatgagcgtt
    33661 ttgaaatgat agaattaaaa aagccgacta ctgaattaat ttttgttgtt tcagtatgtt
    33721 ggcttaattg ttactttcat ttcaaatttt aaaagtcaag ggcgagcctt agcgagttta
    33781 tttacccttg acttttaaaa agcgaatggt tgttgctccc tgcaagggtt tgactccgca
    33841 ggacgcaagc accctttagg gtgtataatt gcgcccttgt aaccaaggga caattatgtt
    33901 atttcatctt tagatgattt ttctacatta tcatctattc tttcttctaa aatttccatt
    33961 atgtttaatc ttatttcttc atcatttaac gtttttatta acttataaaa ttcatctttt
    34021 gttaaatcaa tactttcttc aaaaatactt tcaaacactg cacctttttc tataagtctt
    34081 ttgtttcttg cttttctttc ttgttcatta agttttttct tcaactgtct tttttgattt
    34141 tgtaattgct taatgctttc ttctttcttt tcaatctgtt cttcaatact taatctttta
    34201 cttgccatca tgtatccttt cttaaaataa aaaacgacta gatttttatt tctaatcgtt
    34261 cttgttttaa atattataat ttgctatatt gcattttaat tttaagtctt ctatatatct
    34321 ttccatgtaa ttccaatctg gagtacctct actgtctatc ggtaatttaa ttttgatatc
    34381 tggcaatact gtgctagata tttgatcttt atattcagta ttttttaaag cttgcctaat
    34441 aattgaagtt aaatagaatg ctacttcttt attcaattct ttatttttta attttaaaca
    34501 atgaattttc atatctaggc ttgctttata tttatgataa aagactgctc ctaaaaatga
    34561 aacagatata aaattttcaa agactctata atttttatca tctatatctt cgtagtaacc
    34621 taagatacca ttgtcaatat ttgtagcact aattctagga gtttttccat cgagtaaata
    34681 tctttttgga atagatgagc ctgttggtac ttaactcgat ttcccctttt tttcggtaat
    34741 aaatatttct ttttattttg ttgtctgata tttttcctac ctgtcctttg taggatgagt
    34801 attttctaga ttttcttgaa taacttttta cttgaagttt tagcttttga actagtcgtt
    34861 gtactttctt tttgtttatt atcagtcctg atctttttaa tattgctgtt attctctata
    34921 tcctattttt cattcatgat attcttttac taattttatc ttaaattctg tgctgtattt
    34981 gccattaaaa aactgacctc ctttagttag ttttttggcc taacttttga gggtcagttc
    35041 aaaatttgcg acttttaaat gaattccaat attcaattat taagagttaa catggtgctt
    35101 gccaatagga atcattagag gcgaattgga aatagggtca cgtataattt ttgcttcaag
    35161 attaaagata tctttaacta gtttatcatt tagtatatct tcaggctttc cctctgcaac
    35221 aagtttacct tctttaattg caaataggta atcagcgtat cttgctgtta gatttatatc
    35281 gtgcaaaatc atgcaaatgg ttgtcttata tttttggttt agatcagtca agaggtctaa
    35341 tagttctatt tgatatgaga tatccaagta agtagttggc tcatctaaaa gtaggatact
    35401 tgtatcttgg gctagggcta gagctatcca tactctttgc ctttgacccc cagaaagttc
    35461 ttcaactagg ttatttgcta gatcttcaac attggcctta accattgatc tgtttattat
    35521 ttcaaggtca tcttttccaa gactcttaaa aggctttctg taggggaaac gaccacggct
    35581 tacaagatca gctactgtta ttgattcagg gattattgga gattgaggta atatagctat
    35641 gtgttttgct aaatcttttt ctttataaga attaattgat ttattatcaa gcaatacttc
    35701 tccctctaat ggctttataa gtcgagacaa ggttttaatg agtgttgatt tcccacaacc
    35761 atttgaccca ataataactg atattttttc ttcaggtatt tttatattta tattttccaa
    35821 gattattttt tcatcataac cgcaggtaag attatttgac cacagacctt tcattatata
    35881 ttcctcctgt tcatttttat tagtaagtat attaagtatg gtgaacctaa caagccagtt
    35941 acaacaccta ctggatatct agctggtaaa atattttgag agaatatgtc tgataacaaa
    36001 actagtaaaa ttccaaccaa tccagctaat attgggcttc ttttcttgcc aatatttaag
    36061 gctatgggac cagctaaaaa agatatacaa gctattggtc ctgtaattga agtagaaaaa
    36121 gcagttaaag atacagcgca aaaaattaaa acaagccttg aaagctcggg atttgctcca
    36181 agtccgattg ctatttcttc accaagttca ataatttcta gtcttttatt aaaaaataaa
    36241 actaatatag tagcaataat acttactatt agaacaagag gtatgtcatc taactttgta
    36301 aaagataaag agccactgag ccatctcata acttcttgta attcatatct tgctactttc
    36361 aacaataaaa atgaggtgcc tgctcttgtg acagcttgaa aaccaatacc taatattatc
    36421 agtcttgctg ctgaaaaacc atctttttta gctagtaaaa ataatattaa agatgatgtt
    36481 agtccacaag ttattgaaat aattccagta gttaaactat ttgtttttaa taccaatatg
    36541 caaaagaccg ctgcaataga tgaagaactt gtgacaccga ttatatcagg acttgcaaga
    36601 ggatttctta acatagtttg aaagataaat cctgccaatc caaaagacca gccagctata
    36661 attcctgcta ataattttgg taatctaatt tccataatcg aaaaactagc tccaggaaca
    36721 gtttcactat ttaagacttt aatcaaagtt gaaaaagaat aactttcatc tccgataagt
    36781 aaaatgaaaa atgatagact gattattatt aataaaaata gtgaggaaaa tagtgttatt
    36841 ctattttttc ttttttgaat acctataatt aaattttgca ttagttatta acccctctat
    36901 ttttcatagt tacataaata agtactggac ccccgattat tgcagtaatt atccctactt
    36961 caatttcacc tggtttacct aacatacggc cgattatatc acatataagc aagagctctg
    37021 cacctataaa agatgaagaa atggtcattg tgcgtatatc tttgcttata aataagccac
    37081 aaaagtgagg aactataaga cctacgaagc caataggtcc accaattgca gtaatacttg
    37141 aacataaaag cacacttgca attattgcaa gtgatcttat cctattaaca ttaactccaa
    37201 gaccaacagc catttcatca cccatagcta aagcgtttaa atctgatgaa ataaatatag
    37261 ctatcaagtg acctaaaatt ataaaaggta gtagtgtaga tatagaagat aatgtagctg
    37321 ctccaaggct acctatttgc caaaatctaa atttgtctaa gacgttatta ttcggtaaaa
    37381 ttaaaaaact tacaaaactg cttaaagcca tactaacaca agttcctgat aaggcaagtt
    37441 ttataggggt aaggcctgct tttccgctta cagcaatcgc gtatacaaaa attgcactta
    37501 ctaagccacc aatgattgca aaacttatat ggcttatgct tgatgaaatt cctaaaaaag
    37561 aaagaccaat tactacacta agacttgctc ctgtgtttat accgagtata cctggatcag
    37621 ctattgggtt tctagtaact gattgcatca atacaccgct tatggcaaga ctagaacctg
    37681 ctaaaattgc aaaaatagtt ctaggtattc ttttatatat aattgattta ataaaatcat
    37741 catttgtatt acccattcca aaagctgcta aaaaatctct gatattaatt tcttttgttc
    37801 caagctttaa tgacaaaaat attgtaataa gaagacctag gcagattaca aaaattatgc
    37861 ctaggtttat ttgtttttta tttcgcattt ttgcatgcat ttcctaaaag atttagatat
    37921 tcttcaatag tatagtttat tgaaagtggt gttggagtgc atgaggctgc taacggtgta
    37981 ttatctggaa ttacagcaac ggcaccattt ttaattgcat ttattttacc taaaagagga
    38041 tctttttgta aagcttcaag agttttatca tcaccataag ttatgattac atcagcatca
    38101 tttatcttat ttgcttcttc tgcagaaatt tcctttgcaa aactatcttc actctcaaat
    38161 tcttttaatg attcagggaa aactagacct aaatctgtta aataatttgc tcttggatct
    38221 ttgctagtat aaatccagaa ttttgatgta tctgcagcat taatcatagt aaataatact
    38281 ttttttcctt tgatttttcc tttgatttct ggatgttttt ctaattcttt ggatatacga
    38341 gcttcagtat ttttgattaa ctcatcacct tctttttcca tacctaaggc ttttgaatca
    38401 attttaatca tatctctcca taaagtttgc caaggtttag atttgtatgc tgctacagga
    38461 gcaatttttg atagagtgtc ataatcttct ttagttatac cagaataacc tgctaagata
    38521 acatctggtt tagaatttga tattgcttca aagttaagtc catccaaatc gtcaaatagg
    38581 ttagctttac catttagttc tttgattttt tcttctgtcc atggtaaaac tcctttatca
    38641 gcacttacac cgtaatttgc ttttgaaaat ccaacaggaa ctattcctaa agctaatgct
    38701 acatcatgat ttccccaagc aatagttgca actctttcag gttttttatc taatatagtt
    38761 tgaccgaaag catgatctaa aactatttta tcaggcgcat gctctttaga agtattttct
    38821 tcatttttaa cagaattaga agaacaagcg ctaaaaacta tacacatagc taaaatagct
    38881 attagaaaaa atttgttttt cataaaaact ccttaaacat atttcaagtc tattgtatcg
    38941 ataataatta tcattgtcaa tagatacagt tacaaattta ataatataat tttttcaaaa
    39001 aaggatctag tttttatttt tagttaaatt atgtctatat ttttcattaa ctcatcaata
    39061 aaaatttgtt tgctaatatc tctttcttct gattttgttt caaggattat tgctacatca
    39121 ttcatatttt taggtaaata ccaaccatct ggcttatctg aatatccctt gaagcctaat
    39181 tgattaaaag tagttatttg accagtacct tgattgatgt tttcttcaac ttcattaaag
    39241 cctatacttc tcttgcataa tccctaactt gatcttctgt ccttaaagtc attttctatt
    39301 cctcgtcact aaaattatct tcaaaactaa taatatcatt aggagtgcaa gataaagcct
    39361 tacatattct ttctaaattc ttaaatgtaa ttggtttatc ctttcccatt tgtgccataa
    39421 catttgttgt aagtcctgcc atagctatta catctgtttt ctttagtcct ttttttgcta
    39481 actgtatcca taatggttta tagttaagtg ccataatatc cctctttttt tcttcattag
    39541 atttatttaa ttatagcata aatattgatt tcattcaatc ttacattgat ttagtgattt
    39601 gttttagaga atttgttgtg ttattccgtc cttattttgc cataaattgt tttaagtggg
    39661 acctcttatc cttaccattt ttacctccta attttgagta taaaaaagac gatagagttt
    39721 ttaatttcta tcgtctgaga tttacatatt aaattttcat cacaaaataa gactctttaa
    39781 agaatcttta aattcattgg tatgctaatt acaatatcca ttattaaaat ggatactata
    39841 agcagcacac caactattta ttttttgagt tttaaacttt ggtagaagtc ttgaactcct
    39901 tatatttaca taactatttg cctctataac tattatgaca cgaaaccaac aagcaagttc
    39961 aagcacctcc atatctttat tcaaatgagg actaagatat tcacaaactt tatcataaac
    40021 ctctttatct tttttcataa aaggggcata caacttagca aatttatcct aaaatttttt
    40081 gttgccttta tcaatcattt caacactcct ttaaatataa aaatgatcct atcaatcttt
    40141 atattgagcc tattttctaa ttgatacctt gcaagaaagg aataatagct gttcctatac
    40201 caagtaggaa tgtaataaat gcagaaagtc atatactgtc attcttttct attaaatcat
    40261 tttgaagtgt ctcaaagcat ccatgatggc ttcttctttt tcaggtgtac actgtggaat
    40321 aatttgttta tcctttttag acttgttgta atgttctcgt aattctattc cacatttctt
    40381 ttttatctgt gcaatatata atgtcgaaac ttttaattca aatttattcc aaacatattc
    40441 tttgatttga gcatatgttg ctttgctctc cgcacttgtc aaattcatct catccagctc
    40501 aatttcaaca cttatgtgct tatcgacatc gagtttggac aaaagtgcta ccgtctcgac
    40561 gtgatgcgtt tgaggaaata gatccaccgg ctggactttc ttcaattcat atcccaattc
    40621 ttggtagagt ttgatatcac gcgccatggt tgcgacattg caggagatat aggcgatgcg
    40681 atcggctcct gtttgggcgc ttgctttgat aaagctttct gtcaagccct tgcgtggagg
    40741 atcaaccaag ataacggttg gttgaatccc atctttaagc caattcttca tagcattttc
    40801 agctgtgtca cagacatagt gggcgtttga aatattgttc agctgagcat tttttttact
    40861 attctcaacc gcttctggaa tcagttcaac accgtagact tctttgacat gcttggcgac
    40921 tgataaacca atggttccaa taccagaata ggcatcaata atcacgtcat ctttttttaa
    40981 ctctgcaaag tcaatggctg tttgatagag tttctccgcc atttcagtat tgacttggta
    41041 aaaggctggg ccagcgattt ggaagtcatt tcccaacatc tggtccgtaa tatagtcttg
    41101 accataaaga gtgcgccact ccttaccaaa aatcgcattg gtattctggt cgttgatatt
    41161 ttgcatgaca gacacaatct ctgggaactg cttgataact tgttcaatca attggtcaac
    41221 acgaaaaact tttggacgag ttgtcaccaa aacgaccatg atttgtcctg aatagtgacc
    41281 acgacgcacc acaagattcc gaatcaatcc agactgttcc ttttcgtcat aaggttttaa
    41341 atcaaaacga cggagcaggt ctcgaagagc tactacgact tggtcaatga caggatcctg
    41401 gataaagaaa tcttcaaggg gcatgaggtt gtgcgaattc ttacggaaaa atcctgtttc
    41461 caagacacca ttcactcgac gaacgggcac ctgcgcctta ttgcgatact tgactggatg
    41521 ttccatacca agcgtttcag caacttctac atctgcaatt ccagcaatct tgtagagact
    41581 gtccttgact tgcttggttt taaacttgag ctgttctgga taagaaaggt gtcctaaatc
    41641 cgcgattcct gaacgcaggt aagccaaatc tagatcttga ttacggtgtg gtgactggac
    41701 aaggtatttt tcaacttttc caaagccaat ctttttattg accttgagga cacgcatgag
    41761 aattttttca ctcggtaaag cattctctac aaaaaagacc aaaccatcta ccttggcaac
    41821 tcctgcccct tcatgggtca agtcaacaat ttcaacttct acaatatcat ttttctttaa
    41881 cattcttttc tctttctatt ggccgacaaa aaagacggca acgttacggt taccatccat
    41941 tataccatga aatttcttaa gaaccaaaac tcttgaagaa gttgacaagg gcttgccaga
    42001 gggagcttaa gaagttacca ccgtcctcta gcgccttatc cgcatcaaag ttaaggttga
    42061 tatttttaaa actgtcgcca gcttgtgata cgatgctttg tttaaggtca tttagggttt
    42121 tagtgaaatc tgcattgctg aggatatcac tctttgagag attcaaggca aaattgatga
    42181 tgatattgat ctggtttcct gttatgacct gatcaagttt gtaatttttt aaggtatctt
    42241 caacaatctt gcgtacatct tcttctgtca gatttccctt gctttcttta gctttggcga
    42301 gtcctgactt gatatcagct agggcaacgt ttaatttatt agcatcatag cctgatttgt
    42361 ccttgttttc agcattgata tctgacaaag cctttagctc ttcttgagcc aaatctttat
    42421 tggcttgcgg caccttggct ccattagctt ctagcgaata gtagatccca gccaaagcac
    42481 tctcacctgt aactggaata ggggctgcta cagtgatttt ggcatgttcc atacccagcg
    42541 ttactgctgc gtttcggtac atatcctgag tcaccttagt gatattttct ggtgtttcaa
    42601 tcttgacctc aagtggcgat ttgtcaccta gcttttgaat cttggctgat gaatacaact
    42661 gtaagctaga gtcattggcc acattcatga ttttagaata aacatcaggt gtcatggtct
    42721 tgagttcttt ggtatctgtt gaggcattgt agcccagttt tttaagagtt tgattttttt
    42781 ggtcttcaga tagggaggaa cctaggacat attcaggttg gacataggtt tcatcgataa
    42841 ctttttgaac atctgttgct gcatgggcgc tattcatagc tgttactgcc cacaagaccg
    42901 cagcactggt cagaaagagt ttctttctca tagggaattt cctcctttac ttttctagag
    42961 taatatatct atcttaaaga aaacttataa caaaaacacc tggtctagcc agatgttgaa
    43021 aagagagtga aacatttgat gatgtaaagg ttaagtcgta cctgtctaga ataataatag
    43081 tttcctccat ttacatagag ttcagcaccg tgaaaaatgg aaatggggtg aatataacta
    43141 taagtctttc cagtcgtatt accaagcaag ggggcaacag tctcacgaga gtactgtttg
    43201 gctagagcca aggtattttc cttgccattt tgggcgataa aatcgatata ggcaggtcca
    43261 aaattatagg cttgaacagc tgtccagata tctacaccct tcttctgcgc cagatagaga
    43321 ttgcctgtca gagtttgaat gccttgccga atgctagagg cattatcatt gatggtattg
    43381 gtggaaccac ttgcagactc actagactgc ataacatcgc cttcttttcc ttttgtttca
    43441 gtataaatca tagcaagcac aagctcttcg tttgctgggg tgtctttttc actcaatatt
    43501 tctcgcacca tgggttgata ggtcatgact tgtttgacat cttgatgaac gcggtaagct
    43561 ttatatccag caaaaaggaa gactgctagt acaagcactc ttcgaattcg tttaaacatt
    43621 atttactttg gatatcctcg atatttttga ttaagataga gtaggttcca ttttcgtttt
    43681 ggataaactc aacagactcg gcgtcttgat agacgttatt gggaacgatg agctcaattc
    43741 catttgataa ggagagtttt tggttttcaa atttctttaa ttggcgactg gcatcaattt
    43801 catcaaattg aacaggttct ggtacggctt ctttgacttg gtcaataaag ctcaaacgag
    43861 ccgtcagatt gttgtcaaaa aggtcattag ccaatttctc aggtgacaat tcattgcttt
    43921 cttctaggtt gttgaaaata gctgatttga ccttggattg aaattgaaaa tcatctgtgt
    43981 taaaagattc agcaattctc tgggctgttt tttccagttc cttgatagat tttttaggag
    44041 aaatcttagg agcgacagca agaagattat ctgaaaaata gttcaaaaaa gtcccgttgt
    44101 acttgattcg tttttcaatc aggtgatact tgctactctg aagattgacc accaaggcct
    44161 catcagctcc tgttccaaat ccaggcaggt tattctgagt tagcttgatt ggattatcaa
    44221 cttctcctcc gaggtgggtc aaggtctccc gcagggcaat tcgcaagaaa gcgaaatgtt
    44281 ctacaccttc tttagaaaat tgaacaaaaa tcaagtcatt ggtcttgaga ttttcagaaa
    44341 tgctaaactc ctctttccag agattagcca gcgttactga tgtctccaac aaatcgtctg
    44401 taatatgatt gaagaaggga ttttcttctt cgaaaatccc agtcttggct tcatctgaat
    44461 acacatgttc aattttttta cgtaggtatt cttcgatttt tggagtaata ttgagaaact
    44521 tatctgctaa gaacagctcg gtatcatccg gactgaactg gtgaataatg gctttcttaa
    44581 tataaatgtc cataaaagtt ttattcctcg tataatggga aggcatctgt caattctttg
    44641 actgcacttc tcacttcttc taatacagcc tcattttctg aattcttaag ggttttaatg
    44701 atgagttcag ccactttgcg actttcttct tcaccaaatc cacgtgcagt aatagctgct
    44761 gctccgatac gaatcccact tgtcttgaat ggtgacaagc tttcgtaagg gattgagttt
    44821 ttatttaagg taatattgac ttcatccaac aagttttgag caactttgcc gttttctaca
    44881 actttagtca catcaacaag gaagagatgg ttttcagttc cacctgaaat aatacggaaa
    44941 tcagggtctt gcaagaagac atctgccata gccttgctgt tcttaattac attggcagca
    45001 tattccttga aggctggatc caaaacttct ttgaaggaaa ctgccttagc cgccacaaca
    45061 tgctctaaag gaccgccctg aatacctggg aaaatagctg aattgatttt tttagcaagt
    45121 tcttcgtcat tggtcaaaat caaaccacca cgaggtccac gaagggtttt gtgggtcgtt
    45181 gttgttgtga tatgagcgta tggaactggg cttggatgaa ggccagccgc aaccaagcca
    45241 gcgatatggg ccatgtccac catgagcttc gcaccgacag catctgcgat ttcacggaat
    45301 tttgaaaaat cgataatttg agaataggct gaagcaccag ctacaatcag ttttggtttt
    45361 acttcttggg cttgtttcaa gatagcatca aagtctaaga gttccgtttt aggatcaaca
    45421 ctataagaaa caaagttgta ggtttgacca gagaagctaa caggagcccc atgagtcaaa
    45481 tgaccacctg atgccaaatc cattcccata accgtatcac ctggctcaat caaggacatg
    45541 taagccgcac agttagcttg gcttcctgaa tgtggttgaa cattggcaaa tttagcaccg
    45601 aaaatttctt ttgcgcgttc aatagcaaga gtctctacaa cgtctactac atcagttcca
    45661 ccataataac ggcgtcctgg gtaaccctcg gcatatttat ttgtcaagat agacccttga
    45721 gctgccataa cagccttgga aactacgttt tccgaagcaa ttaactcgat attattttgt
    45781 tggcgttctt cttctttggc aatagcattc cagagatcag catcatatgc tttaaaatca
    45841 tctttgtcaa aaatcatagg tcttctcctt tattgtgtga ctagtccatt agtttgattt
    45901 tacaataaga aaatcaaact aacagatgcg aataaaccgt ttctgcattt tatcacaagt
    45961 atagccaact ttttcataaa atgcatgagc acccagacga tgattggcag aatttaagcg
    46021 gataaaccca taaccacatc tttttgcttc ttcttccaac ccttgtagta aacttttacc
    46081 aataccttga ccttgcgctt gaggtgaaac tgctaaagct aagatattaa atcctgcttt
    46141 ggaatagagt gattcgtaaa cttcagcgtg gacatatcca agtaagacat gattagctgc
    46201 atcctcatag ccaagtagga aatgatggga atcctgagac agtctagcta gttggctagc
    46261 cgtttcctct ggactaaaag tataacccaa agcctcttgg ttgatgtcac atatcgcttt
    46321 cacatctgtt tcttgcaaat ctcttagcat ttcaagcctc ctcaaaagaa atctctgaca
    46381 accgagcaag aatatcttct cgtttaattg cgccttggcg taagattttc accttgtctc
    46441 cagacaaatc cacaatagtt gaatcctgtc cagttagaaa agcatcgtct tccagaccca
    46501 gaacctcttg gtcaaaatcc ttcagaattt gttcaaaggt tacaccactt gcctgacctg
    46561 agatattggc agacggccca atcaagggac ctgtctctcg aattaaatcc agtgtgatag
    46621 ggtgactggg catccgaaat ccaatagttg caaggtcaga atttacccaa tagggaactc
    46681 ggtcattggc ttcgagaata atggtcaagg gacctggcaa aaaggtctct acaagttttt
    46741 gtagataagc tggctgattc tttgaaaagt gcaagatgtc ctcgaaagag gcgatattga
    46801 gattgagtgc cttatctcta ggacgacgtt tgagttggta aacatggtca actgcttttt
    46861 catctaaggc cttggaaaaa agaccataaa cagtctctgt aggtagaacg acagctccac
    46921 ccttttccaa ctcttgtcta atcctgtcca tcatcaacca caaccatcct attttgacca
    46981 aattggtctt tgagtgttcg aactcttttt tcaggaagat gttttctaaa aagttcggga
    47041 acactttgac cttgcttgta tccaatttca aggtaaatct taccaccatc cttgagatag
    47101 tcttttgcat cttccgcaat tctacagtaa atagctaggc catcctcgtc tgcaaagaga
    47161 gctagatgag gctccgaatg caaaacattc aagcctacct ctgactcatc ttcacgagag
    47221 atatagggtg gattggatac aattatatca tatttttcag aaatttctgc aaaacaatca
    47281 gattttttaa aaaatatatt aagattttga tcgctagcat tctctgatgc aagctctaag
    47341 gcctcttgag aaacatctgc tgctgtcact gaccaatctg gtctattttt tgctagagcg
    47401 agagcaatag ctccactacc tgttccaata tccagaactg agagattcgt ctcaagattt
    47461 tcagttagaa taagctccac taactcctct gtttctggac gaggaatcaa aacccgttca
    47521 tccaccttta aatgcattcc ataaaaatct gcctgtccaa tgatgtactg agctggcttg
    47581 tgagctgcta gttgctggta aatatcttct acaaattgtt tttcttcctc tgttgtcacc
    47641 tcctgctgga gggcaaaaat aaagtctgta aaagatagat ttttcagact acgatagaca
    47701 aaagagaggc tttccgcttc ctctccttgt cttatcaact cttcttcaaa atttgaaaat
    47761 aattgagcta atttcattat ttgtttaatt cttctagttt ttgtgtttgg tcataaagca
    47821 ccaaggcatc cacaacttcg tccaatttac cagacaaaat cgtatctagt ttttggaggg
    47881 tcaagccgat acggtggtct gtgacacggt tttgtgggaa gttataagtt cggatccgtt
    47941 ctgaacggtc accagtaccg attgtcgact tacgctcagc gtcttgttca tcctgagcaa
    48001 tctgagcaaa gtggtcagcg acgcgtgcac ggataatctt catagccttc tcgcggttct
    48061 tctgctgggt acgttcttcc tgcatctcaa ccttgatatt ggttggcaag tgaacgatac
    48121 gaacggcagt cgcaacctta ttgacgttct gtccaccagc accagaggcg tgatagatgt
    48181 cgacacgaag gtcttttgga tcaatgtcgt attcaacctc ttcaacttct ggcataacaa
    48241 gaactgtcgc tgtcgaagta tgaacacggc cttggctttc tgtcacagga acacgttgca
    48301 cacggtgggc acctgattca tacttaagct tagagtatac agactgacct gaaaccatag
    48361 caaccacttc tttaaaacca ccgacaccat tcatagaggc ttccatgact tcaaagcgcc
    48421 aaccttgggc ttccgcatac ttttggtaca tagttagcaa atctccagcg aaaagtgccg
    48481 cttcgtctcc accagctgct ccacggattt caaggatgat attcttgtca tcgtttggat
    48541 cctttggaag gagcaaaatt ttcagttttt cttcatattc ttctttttca gccttggcat
    48601 ctttgagttc ttgcttggcc aattcttcca agtccgcatc tccgcctgat tccttaatca
    48661 tctcttcggc atcgacgata ttttgaagga cttgtttata ctcacggtag gctattacgg
    48721 tgtcacgatt ggaagcttct tcttttgaaa gctccataaa acgcttggtg tctgaaacga
    48781 catcagggtc actcagcaat tctcctagtt cttcataacg gtcttctaca gcttgtagtt
    48841 gatcatagat gttcattttt cttcattctc cttattgatt tcaggggcaa aataatgttt
    48901 acggcaaacc gagatatagg tttcattacc accaatctgg atctgttctc catcgtaaac
    48961 gggcagtcca tcctgtgttc gcaacaccat ggtcgccttt ttcttgcaat actgacagat
    49021 ggtcttgatt tcgtcaatct tgtccgctaa aagcaagaga tatttggaac cttcgaacaa
    49081 ttcattgcga aagtcatttt tcaagccaaa agccatgacg ggtatgtcta actcgtccac
    49141 aacacgagct aggtcataaa catggtggcg tttgagaaac tgggcttcat cgaccaaaac
    49201 acagtaaggt ttttctggta ggtctcggat atagccaaag atatccgttg tttcctcaat
    49261 cgcaagggca gggcgtttca tgccaattcg actcgacaca tagccaacac cgtcacgcgt
    49321 atccagagcc gaggtcataa tgacaacacc ttttccttgc tcctcgtagt tataggccac
    49381 tttgagaatc tcaatcgttt taccagagtt catggtccca taacgatagt acaactgtgc
    49441 catgtttctt gcttcacgtc catttctaaa tttttgctac attctagtat atcataattt
    49501 tcttaagctt taaacggcaa aatgtggtaa aatagaagaa atcaaaaact agtggaggaa
    49561 gctattatgc catttgtacg catcgattta tttgaaggac gcacgctcga gcaaaagaaa
    49621 gctcttgcta aggaagtaac ggaagcggtt gttcgcaaca ctggagcacc tcaatctgct
    49681 gtccatgtca tcatcaacga catgccagaa ggaacttact tcccacaagg ggaaatgcgt
    49741 accaaataag ctagcttaag cagaattgct taggcttttt caatctccaa gtagcattca
    49801 ttgaagaaat atcctaaatt tgttacaatt tgaaaagaaa cttggagaat ttccaagaaa
    49861 agagcaatta attaaaggaa acattatgat tacacgtgaa tttgatacca tcgctgctat
    49921 atctactcca ctaggtgaag gggctattgg tattgtccgc ctgagcggaa cagacagttt
    49981 tgctattgcg caaaagattt ttaaaggaaa agacttgaac aaggttgcca gccacactct
    50041 caactacggt cacattatcg atcctctgac tggtaaagtc atggacgagg ttatggttgg
    50101 ggctatgaag tctccaaaga ccttcactcg tgaggatatt atcgagatta acacccacgg
    50161 tgggattgcg gtgaccaatg agattctcca gctagctatc cgtgagggag ctcggttggc
    50221 agaacctggt gaatttacca aacgtgcctt tttaaacggt cgcgtagatt tgacacaggc
    50281 cgaggcggtg atggatatca tccgcgccaa gacagacaag gccatgaaca ttgcagttaa
    50341 gcaattagac ggctcccttt ctgacctcat taacaatacc cgtcaagaaa tcctcaatac
    50401 acttgcccaa gttgaggtca atatcgatta tcctgaatat gatgatgttg aggaagctac
    50461 tactgccgtt gtccgtgaga agactatgga gtttgagcaa ttgctaacca agctccttag
    50521 gacagcccgt cgtggtaaaa tccttcgtga aggaatttca acggctatca ttggacgtcc
    50581 caacgttggg aaatcaagcc ttctcaacaa cctcttgcgt gaggacaagg ctatcgtaac
    50641 agatatcgct gggacaacac gagatgtcat cgaagagtac gtcaacatca atggtgtacc
    50701 tctcaaattg attgatacag ccggtattcg tgaaacagat gacatagtgg aacaaatcgg
    50761 tgttgagcgt tcgaaaaaag ccctcaagga agccgacttg gttctactag tgctaaatgc
    50821 cagtgaacca ctgactgcgc aagacagaca acttcttgaa attagccaag ataccaatcg
    50881 cattattcta cttaataaaa ccgacctgcc agaaacgatt gaaacttcga aactacctga
    50941 agacgttatc cgtatttcag tccttaaaaa ccaaaacatc gacaagattg aagagcgaat
    51001 caacaacctc ttctttgaaa atgctggctt ggtcgagcaa gatgctactt acttgtcaaa
    51061 cgcccgtcac atttccctga ttgaaaaagc agttgaaagc ctacaagccg ttaatcaagg
    51121 tcttgagctg gggatgccag ttgatttgct tcaagttgac ttgactcgta cttgggaaat
    51181 cctcggagaa atcactgggg atgctgctcc agatgaactc atcacccaac tctttagcca
    51241 attctgttta ggaaaataag aaaaatccat gatccttcat tcggtcatgg attttattgt
    51301 ctttattagt aatctggtct taagacccct gttacagttg ccttagttgc ttcgtagtcg
    51361 ccatctacga caaccttgat aatgcgtttg gcatcttctt ctggtgctgg aacaagaggt
    51421 agacgagtgg gtccagcttc aaatcccata tagttaagaa ctgccttaac tggagcagga
    51481 cttggataag agaagagagc attaacctta ggaatgaatt tacgctgaat tgctgcggct
    51541 ttcttcatat cgctttctgc aatggcagta aacatctcgt gcatttcatc cccatttgta
    51601 tgagaggcaa cagaaataac cccatccgcc ccaaggttca tggcatggaa agcatctcca
    51661 tcctcacctg tataaatcaa gaactcttca ggcttgtgct caatcaagta agccatatta
    51721 gccaagctag tacattcttt gacaccgata atatttggat ggtcagccaa acgaagcatg
    51781 gtttctggag tcaattcgac aactacacgc cctggaatgt tatagataat aattggtagg
    51841 tcagaagcat ctgcaatagc cttaaagtgc tgatacatcc cttcttgaga aggtttgttg
    51901 tagtaaggaa caatagcaag cccagctgcg aaaccaccaa attccgctac ttctttgaca
    51961 aactcaatag agtcacgcgt atcattagta cctacacccg caatcaaagg aacgcgtcca
    52021 ttgacaacct tttgtacagc cgcaaacaac tccaactcct catcgtgggt caaagttgga
    52081 ctctcagcag tcgttcctgc gagaagaatt ccatccgtat gatgggccaa taaatgctca
    52141 atcaaggctg gaatagcatc aaagttaatg gaaccatcct catggaaggg ggtaataaag
    52201 gctgtaatga ttttacattc ttttaaatct tgataagaca cgaaaacacc tctctatttc
    52261 aaagaaggag ttcatctgaa ctcctaaacg atatgactat tttaattcaa atttcaattc
    52321 ggctgttgga cgaaccaatc cacgttcatg aagagtttca gcaatctgaa ctgagttcca
    52381 agcagcacct ttgagaaggt tatctgaaac aacccacatg tgaattcctt tttctgcatc
    52441 catgtcttta cggatacgac caacaaaggt atcacgcgaa ccaactgcat tgatagcttg
    52501 aggatagatt tgatgagcta catcatcttc aagaacagca cctgggaagg ctgcgatagc
    52561 tgcttttact tcttcgattg gagccacttc ttttgtttcg atataaacag actcagagtg
    52621 agctgacaag actggaatac gcacacatgt tgcagatact gcaatgctat catcttccat
    52681 aattttctta gtttccttgg tcatcttcat ctcttcgtac gtgtaatcat tatcagtgaa
    52741 aacatcaatt tgtggaagag cgttaaaggc gataggataa tgtttcttgt caccacctga
    52801 aggcaagatt tccgcatgca aatcacgtgg tttcacacca tcattcaaga cttcacgaag
    52861 ttcacgttgt gtctcaagaa ttgctcccat accagcacct gaaacggctt gataagttga
    52921 aacaatgata cggtccaagc cccatttttg gcgaaccggc tcaagagcca ccatcatttg
    52981 gattgttgaa caattagggc aggcaatgat tccgttgtga gcatcaagtg catgagcatt
    53041 gacctctgga acaaccaaag gaacatctgg attttgacgg aaataagatg tattatctac
    53101 tactaccacg ccagctttta ctgcgtatgg tgcatactta gctgatgtag aactacctgc
    53161 tgaaaagaga gcaatatcaa ctccttcaaa agctgtttca gtcgtttctt caattgtaat
    53221 atcttgatct ttaaatttca atgacttacc tgctgaacgt gcagaagcaa ggtaacggat
    53281 tttatcgatt ggaagtgttg attcttccaa catttttatc atctgagcac cgacagcacc
    53341 tgtcgcgccg actacagcaa ctgtatatcc cataaataac ctctttcgga attttctaaa
    53401 aatttctata atagaagtat tatactactt tttccatgaa ttgcaaagct ttttcattat
    53461 tttttggaaa ataaaaatcc cagtcgctag actagggact aagaggcatc ttcatgtgat
    53521 gagcaggttc acacaactca tcaaggtccg ctcctgcgtt atgacctcct tatgctcaat
    53581 agtagtccga agactaccta tcgactcatc gcatattcta tattactaga gatacttgat
    53641 tttgtcaata agaaattttt tcgatcgagt ataacaaaaa actcttgtat tcaagagttt
    53701 ccctatacat atcatgctaa ttgccgggat tgaaccggcg acctcatcct taccatggat
    53761 gcgctctgcc aactgagcta aatcagctta cttaagaagt atactataat cagaaaaact
    53821 tgtcaagttt ccttagaaat tttccatagg aaaaagccag gtaagaacta cctagcttat
    53881 cttcttctat ttacttaaat caattcgacg accaatttta ccaataataa tcgctccaat
    53941 aatcaatgaa gcaaattcac cgattcctgt tgtaaaccaa gtaaggaaga atggtaattc
    54001 tgctacaata tttaactctg cagcgatagt aaacatggaa attgaaaaga ggattgaaaa
    54061 gaagaaatga tcttttcgaa tcaatccgtt aaagaggtaa tccttgctat attttgcaaa
    54121 aagccaaaca cctaaactga ggaatactaa ggttgaacca ccaccaacaa agacatctag
    54181 cagtccgaag ctaaagaaat tagcaatcat acaaccgatg gtaactccga tgatgtactt
    54241 aggattgtaa aaagccataa agttcatcat ttctgaaata cgaaactgat aagcaccata
    54301 gctgatggca tttaggggcg gtgtgacagt caaaacgacg tagatagcag cgacgattgc
    54361 aatatctgca acatcacgaa tagttaattt tttcatcttt tctcctttgg cggttatccg
    54421 cgtgtaatat gcttggtgaa agaagctaag caccaagggt tgattcattc aaccttacta
    54481 gtatagcaca atagcctgct ttatgctata cttaaagcat gaaaaaacct attcaaaaat
    54541 tttttaacaa tgaaatctta gcctatctct tttttggcct tgcgacaact ctagtttcga
    54601 ttctctcacg actagtcatt tatcaactaa gtcatcagga actccttgct acggccttgg
    54661 caaatattat cggtatctta tttgccttta tcacaaatga tacgattgta tttaagcaaa
    54721 aaaagaaaaa tagacttatc cgtttagtga aattttctct tgctcgcctt tctacttttc
    54781 tgttagactt gtttttaact tttctctttg taacccaatt tcctcacatc atagggcaat
    54841 tcgtaactga aaacattgat aagataaatg ctattgaaac aataattgca caaatattca
    54901 ttattatcat caattatatc ttgagcaagg tctatatttt tagaaaataa tgctccattt
    54961 atgagccttt taattgcctt ctataatgat ttaggataca atgaaacacg aaacattgaa
    55021 aggaaaacag tatgttaaaa aatctaaaat cgttcttgct tcgaggaaat gttattgacc
    55081 ttgctgtcgg tgttgtcatt gcctctgctt ttggtgctat cgttacttca cttgtaaacg
    55141 acattatcac tcctcttatt ttaaatcccg ctttgaaagc tgctaaagtc gaacgtatcg
    55201 ctcaactttc ttggcatgga gtcggctatg gtaacttttt aagtgctatt atcaatttta
    55261 tctttgtggg taccgccctc ttctttatta tcaagggcat tgaaaaagca cagaaactga
    55321 ctggcataaa gaaagaaaaa actgccgaaa aaaaaccaac cgaattggaa gtccttcaag
    55381 aaataaaagc tctccttgag aaaaaataat cgattaaaag gatctagcgc aaagctaaat
    55441 ccttttttct ttactctttg ggtaacttgc ctgctttttc aagcattttt ttgataagat
    55501 aaggcatctt aatattctcc cgcccttttt tctcaatcag ttttttcaca aattctggca
    55561 tttgtaaatc ttcagattca gctaaaatgt ttttcgtctc gtctgaagga actaactcat
    55621 caaaggtctc ttcttctggg agaaattcct taaactcttg attttcattg actctaactg
    55681 tattgaccaa agcatcaatc aaacgagaat ctgtatttgg cattggtgga cgatggtagt
    55741 ttaccccaaa ttcctgacat aaatcataac attccacatc attgtcaaac aagacctcaa
    55801 tatgctcact gatgaaacta ataggtacaa aaatataatg gtctggatgt tctgtctgtt
    55861 ctctgagata ctccaaaaca tctggtttaa tccatggaat accaatatca ctctcactct
    55921 gccaagtgtt ggtatattgt tctgaactca agcccagttt ttcagcgact agcttgctat
    55981 tttcgaaaat ttggtctata taaggatctc caaagtccaa ggcaaaaata ggcacactat
    56041 gggctgaaaa gatgacttta aagctgtctt gctttacttc ttcttttaaa atcttagcaa
    56101 tttcatctgc ccaatagttt aagagcgctt cttcctgata ccagtcctta atgaccaaaa
    56161 attgaatttg tttgctttct aaaaattttt catagcccat gacagagtag aaagaataat
    56221 ggggctccaa aatcaagcaa atacactgtt caattccgtc tgcttccatt tgaccgatca
    56281 catctggaat aaagggactg gaaaacttat tagcaaagta gacactgtat tcattcccca
    56341 gcctagcttc taccaaggca acctcttgac gggtaatttt ttgcagaggc gtgcctccaa
    56401 ttcgtacata attatcatag agagtctgaa tctcgtggtc ttggggtctc atcccacgac
    56461 gaatatttgt gaaaaaatca gctacacctt caaaggtaat ctcttctggt gaaccgaagg
    56521 tcatcattaa aattgctttt ttcatgactg cttccttgtg atgtttttat caagtttatt
    56581 ttatcattaa ttcatcgata agtaaacgct agcataggga cattctcaat cttctgtctt
    56641 ttgtttttct cttctttcta tgatacaatg gaaaaaataa attcaaaagg agttttttat
    56701 gacttatcca aatctcttgg accgcttctt aacctacgtt aaggtcaaca cgcgctctga
    56761 tgaacactct actactactc caagtacaca gagtcaggtt gacttcgcaa caaatgtcct
    56821 aattcctgaa atgaaacgtg ttggactgca aaatgtttac tatctaccga atggttttgc
    56881 tattggaacc ttgccagcca acgatccgtc tttaacacgt aagattggtt ttatatcgca
    56941 catggatact gctgatttta atgctgaagg agtcaatcca caggtaattg aaaactacga
    57001 tggtggtgtg attgaactag ggaattctgg tttcaaactc gatccagctg acttcaagag
    57061 tcttgaaaaa tatccaggac aaacgctcat cacaacagat ggaacaagct tgctaggcgc
    57121 tgatgacaaa tcaggaattg ctgaaattat gacagccatt gaatatctaa ctgctcatcc
    57181 tgaaattaag cactgtgaga ttcgtgttgg ttttggtcca gatgaagaaa tcggtgttgg
    57241 tgccaataaa tttgatgcag aagattttga tgtggatttt gcctacactg ttgatggtgg
    57301 tccactaggt gaacttcagt acgagacttt ctcagccgct ggtgctgaat tgcatttcca
    57361 aggccgtaat gtccaccctg gtactgccaa agggcagatg gtcaatgccc ttcagctagc
    57421 aattgatttt cataatcaac ttccagaaaa tgaccgacct gagttaactg aaggttacca
    57481 aggtttttac catctaatgg atgtgacagg tagtgttgag gaggcgcgtg caagctacat
    57541 cattcgtgat tttgaaaaag atgcctttga agcgcgtaaa gcatccatgc aatctatcgc
    57601 tgataagatg aatgaagaac ttgggagcga ccgtgtcact ctcaacttga cagaccagta
    57661 ctacaatatg aaagaagtca ttgaaaaaga tatgactcca attaccattg ctaaagccgt
    57721 tatggaagat ctaggtatca cgcctattat cgaaccaatc cggggtggaa cagacggctc
    57781 taagatttcc tttatgggaa tcccaactcc gaatatcttt gcaggtggcg aaaatatgca
    57841 cggacgtttt gaatacgtta gccttcagac tatggaacgt gcagttgata ccatcattgg
    57901 catcgtagct tataaaggct aaaaagacga ggtagctcag ctacttcgcc tttcttttta
    57961 ttctactggt ttttcttgat ttccagtagt tgtagaagat tctgttgttt tattttctga
    58021 agttgattca gcaggtttag aatctcttgt attgcttggt ttgttttcgt cgctagcagt
    58081 ttcaatgtta gattctgcag ttgcgtttgg ttggttctca gcactggtgt tatcaccatt
    58141 tgcttcagca tttcttgctg gacttgtttc ttcacttgcg ctagcttttg actggatttg
    58201 atgattcaaa actagaatag cttttgtcga ttcaagtaaa gctgttttgt ctttactatt
    58261 agcagaaagt tgatctaata atgcatccac cttatcaaaa gtccgcatca gatccattat
    58321 tactttctaa ataaaagtga agcgacatga gaatatcgta gagtttttga tagagtacaa
    58381 gtgtctgagg atcttgctca gcattttcct tttcttgttg aagggcgcta gcgatacgag
    58441 tcaagacatc ttttacctga ctgtttactt catccaagtc tgcatcagcc ttgtttgtgg
    58501 cagcttttag attttctact tcttctgcca aagattgtct gattccttct tcatggattc
    58561 gttccaagag ttgatttgcc ttgctcaaaa gactttctac ttcttccttg ctatctgtcg
    58621 cagattattg gttgctatct accatgtact cctaaaacag gagagttata atccaagatt
    58681 acaaggcctt acagaaataa gaaatccaga taagacaatg ttcgtccaag acgctattcg
    58741 cttcgcacag cagcacggat tcaatatgct ttaattttaa agtttaggtg tcaagacctc
    58801 tttttagtgt gcccaaaatt tagagaagta atcaatcaac taacttttat ttttttcaaa
    58861 ctttcagtaa actgacctaa agctaactca atctgtcttt gttcgatagg cttgtctttg
    58921 tagatgcttc tgctatcagc tagaagttga tctacttttg ccaagactgc cttctcatca
    58981 aaagttccag gttgatagtt ggattgcagg gatggaatct tgtttttcaa agccgcttca
    59041 tatcccttag tttgaacctt gatgtagtga ttgtggtcgc cacgaggaat cacaaaacct
    59101 tctgaatctt cacttataat tcgattggca tcaaaaccat gaccatcttc ttcctcatgg
    59161 tggacatgta gtgacggatt acttaataca gaactagaag aacttcctac ctcttccgtg
    59221 ttagagtgtg atgggggatt gttaagagat gacttaggaa tatagtgata gtgaccccat
    59281 gtcttactat ataagcatca cctgtatctc tgacaatatc attagggtta aagacataac
    59341 catcatctgc tgcagaaaca ccattattcg gtgtcaccga caaagattga ctgagagctg
    59401 tagtattctc tgataattat acttttgcag ctgctaattc acctgccgac aagtcactct
    59461 caggaatgaa atgatagtga ccaccatgtg gtactatagt agattgaaat agaatatgag
    59521 caaattgata aggggatttt aaagtaattt ctaacaatga tttagaaact atgatgtgct
    59581 attctaaatt caactcacta tatataacca tcatcggtag tataacgtcc ctgtaatttt
    59641 actacagata cttctgcact agctccttta tcgtctttac catgttcttg tttttggcga
    59701 ttgatttcat cttttattcg tacattttct gcatgagctt gatctttaag gtaaacataa
    59761 tactttccat ctaccttaat aatatatcct cccttaacct aactgacgat atcttgatct
    59821 ttcggctgat agttgggggc tttcattaat agctcttcac taaagagcgc atccaaagga
    59881 actttaccat tatagcagtg ataatgatcg ccatgagaag ttacataacc ttgatctgta
    59941 atcttaataa caatttgttt tgcttgaatt ccttcttttt gactaaccta gtctggagtc
    60001 aaattttcag tcttcttagt gtctttatta ctgtttacat atgaaacacg atttttatct
    60061 gtattggcct gttagctatg ttggttcaga gcataaacac acagacttaa ggaaaggata
    60121 acaacagatc cagctgctat atatttcttt ttaaatttca taattacctc atttctataa
    60181 ttatttatat gatgtcttca ttattaaatg attaaataaa ttaattaacc aattaattaa
    60241 ctagtaaata ttccacctct ttttaagttg tatgtcaaga aattttatat attaataata
    60301 aaatgaaatt ctcccaaagt cagagtttta tttctaactt ttgagagaac ttcatttttg
    60361 attcagactt tttctactgc tattccttac gctatgagat cagataaatt cttttttatc
    60421 acttctccac ttggcaatct taattcaatc gttccatcca tattgaatat aacactatct
    60481 aaacctaatc cgtaactagc tgtaaatttt tctaattttt cttgtacagg atctactgct
    60541 ggagcttcct ctaatgctgg atctaacata gggtcactcc ccacattccc ttctggattc
    60601 aacattccat tatccgttga gttttctggt tttacaggtt tttcgtttgg tgcctctggt
    60661 aaagaatctg ctggtttatt ttctgttggt tggttctcaa ctgttccagt agatactttt
    60721 ccattttcag atggtttatt ttcaccattt ccttgaggtg cttctcctgt aaaatctgcc
    60781 atattctttt taatgacttc tcccgatggt aaatataatt caattgttcc gtccatatta
    60841 aacaagacat tttctagctt catcccataa ctttcagcaa attttgctac tttttcttgt
    60901 acaggatcca ctgtaggaac ttcttctaac gttgaattac tagtactatt cccagtttca
    60961 gaaagttttt ctttttctac cttctcacta gtctttggtt cttctacctt ttcatcaagt
    61021 tttgagtttt cttgtgcttt attcctttta aattgtggta gaatacttgg tttatcagtt
    61081 tgattttctt tttccaagat aggtacttcc acaatataag tcgattgatt gtccaaataa
    61141 gcatttgcca tgaaggttac aggaatttta tttccggccg ttctggttgt tccttggttt
    61201 aatttcggaa tcggtaattt aatttcacca actttatagt tattttctaa ataagcattt
    61261 ccatgaaatt catcaaacac tctgactaaa gcatcagttc ctttaggcac tgcaaattga
    61321 gggttcactc ttaaataagt atcccctgca tggaaaggat agaaaatcgt ttgactggcc
    61381 attttgtaag ctaaagaggt tggaactgta aatgtaccat cataacttac ttctggataa
    61441 tcttttgaag cgatagtata cttaaatgtt tgtcctggta aataaggttg atctaattca
    61501 aagtttgcaa tattccctac tccttctcca aatactttac cagatacttt ctccaatact
    61561 tttccatctg gtgttattaa ttttactagc atattgatac ctaatttttt ctccaattca
    61621 ggcggaaaac taaaagaaac gcgtttttga ccattggcta gagtaaagtt ttgattatta
    61681 aacgtactat tttttaacaa attaacaaca ttcgttaatt cttctccagt ataaacttta
    61741 ttcccttctt ttttagcaac tccttcttcg ggtttaaaca gttcatagtt actgtgagaa
    61801 tgaccaattc caaccggttt atgttcatca atcggatctg catgatggtg atctccatgc
    61861 ggataaataa tcgcattttt ttctttattc acgacaatac tttcacgttt gacaccatat
    61921 tgtttcataa tgccagcaat tttttcttcg atttttttat ctaaatcttt catttctttg
    61981 gcattacttg gataatcctg ttcatgagat gacaaagaat ctaatccatt atgactagtt
    62041 ttaacttcct ctaaatgttt ttgcgcagcc ttaatttgct cttctgtcaa gtccttcttg
    62101 aagaaataat gattgtggtc tccgtgactc atgacaaaac ctgattcatc ttcagcgata
    62161 atacgattag catcaaatcc gtatccatct tcttcatgtt tctcatgtga agttcctgga
    62221 ttgattggaa gagatggaga aggtgttgct agactattgt ttggaagagt cggttgccca
    62281 atttgatttg attttggaat gtaatggaaa tgatcaccat gtcttacaat ataagctgta
    62341 gccgtttctt caacgatatc ttttggatta aaaatataac catcagatgc tgaagagagc
    62401 tccttacttg tcgttaaaga agaaggattg cttgaaagac tgcctagact agacactact
    62461 tcattaggtt ttgcatttgt agaaactgta gaaccagttc cactgatagg caccattctg
    62521 gcaatctttt cttctaaggc agaaagcttg ctgtaaggaa taaagtggta atggtcgcca
    62581 tgcggaatcg caactccatt tggtgtacga ctgataatct tagcagggtc aaagaccagg
    62641 ccatctgatt cactgtaacg ttgggcgcta ggtgaatcat agagttcctt caaaagactc
    62701 tggagatttt cagatttatt tgctggcttg ctagttgatc cttttgctac agattgcgtg
    62761 ttattgtcac tagctgttga agaatagctt aactgactcg gttgcatatt ttttccagcc
    62821 agatgtgctt tagctgctgc taattcacta gcagataaat cgcttttggg aatgtagtga
    62881 tagtgacctc catgaggaac gatataagca ttacccgtat cttcgataat atcagctaga
    62941 ttaaagacat aaccatcatt tgtcgtatat cgtccctgag accttgctac agcaacatta
    63001 gagttaacct tctcattatc tttgacatgt tcttgttttt gacgattgat ttcatcttta
    63061 gttcgaacat tatcagcatg agctgcatct ttcaggtaga cataatattt tccatcgacc
    63121 ttgatgatat aaccaccctt gacttcattg acaatatcag cgtctttaag ttgatagttt
    63181 ggatccttca tcaagagttc ttcactaaag agggcatcat aaggaacttt cccattatag
    63241 taatgatagt ggtcaccgtg tgacgttaca tagccctgat ctgtaatttt gattacaatt
    63301 tgctcagcct gaattccttc tttctggcta acctggtctg gtgtcaagtt ttcacttttc
    63361 tgacttgact ggctgccatc cacataagag acacgattat tgtccttatt ttcctgcgaa
    63421 cgatgctggt ttagtgcata ggcacataga ctcaaggata cgataacagc tgatccagct
    63481 gctatatatt ttttactaaa tttcataaat ccctcatttc aataaatgat gaagtttttt
    63541 ctcaacttct tttactttat taaatagttt tctaaaccgg ttatttaacc atttaattaa
    63601 ccagtaaata gtttactatt taaaattact tttgtcaagt ttctgttacg tttttctaaa
    63661 aaagagaagt aacacgaaag gttacttctc cataaaatat gctccattca ttttactact
    63721 gtatcggagc cggttgactt ttttttaaca aagccaagag actatctact tctgctgaaa
    63781 tagtgttatt atctttcgtt ccgagaagaa gactactttt tagaccagtc aatgtctcca
    63841 tagcattttg tctaatacta gaatctgtta ctttttctag caaggcctcc gcctctgcta
    63901 tcttagcgtt aatcacagaa tgctctactt gaggaatttc agtctcatct gtagtatctt
    63961 cagcttcttc ctctgtctct tccgtatcag tgcttggttt ataaagatta tctgctgaag
    64021 gatttaaacc agcgtgattc tctttttcat cagattcagg gtgagttggc tcacttactt
    64081 catcatgtcc cttatcttca tcaggtttac tgtcttggtc tgccttattt ttacgaacat
    64141 ggtc
//
LOCUS       DBMVGT010000004        57305 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.004, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000004 DBMVGT010000000
VERSION     DBMVGT010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 57305)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 57305)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..57305
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.004"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(16..657)
                     /gene="plsY"
                     /locus_tag="AC0DU4_000285"
     CDS             complement(16..657)
                     /gene="plsY"
                     /locus_tag="AC0DU4_000285"
                     /EC_number="2.3.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0008374 - O-acyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006654 - phosphatidic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HIN4236317.1"
                     /translation="MITIILLILAYLLGSIPSGLWIGQVFFQINLREHGSGNTGTTNT
                     FRILGKKAGMATFVIDFFKGTLATLLPIIFHLQGVSPLIFGLLAVIGHTFPIFAGFKG
                     GKAVATSAGVIFGFAPIFCLYLAIIFFGALYLGSMISLSSVTASIAAVIGVLLFPLFG
                     FILSNYDSLFIAIILALASLIIIRHKDNIARIKNKTENLVPWGLNLTHQDPKK"
     gene            793..2736
                     /gene="parE"
                     /locus_tag="AC0DU4_000286"
     CDS             793..2736
                     /gene="parE"
                     /locus_tag="AC0DU4_000286"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005694 - chromosome [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="HIN4236318.1"
                     /translation="MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHL
                     VWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTIL
                     HAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLK
                     KVGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDE
                     AIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVN
                     NVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDYREGLAAVLSILVPE
                     EHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAA
                     RKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQ
                     AILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDAD
                     TDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEE
                     LRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGD
                     KVEPRRKWIEDNVKFTLEEATVF"
     gene            2751..2955
                     /locus_tag="AC0DU4_000287"
                     /pseudo
     CDS             2751..2955
                     /locus_tag="AC0DU4_000287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014166.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
     gene            3156..5627
                     /gene="parC"
                     /locus_tag="AC0DU4_000288"
     CDS             3156..5627
                     /gene="parC"
                     /locus_tag="AC0DU4_000288"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005694 - chromosome [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit A"
                     /protein_id="HIN4236319.1"
                     /translation="MSNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRI
                     LYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMH
                     GNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFP
                     NLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAI
                     IQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVR
                     VNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDN
                     FTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLRIVEGLIRVISILDEVIALI
                     RASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLA
                     AIIGDERTMYNLMKKELREVKKNFATPRLSSLEDTAKAIEIDTASLIAEEDTYVSVTK
                     AGYIKRTSPRSFAASTLEEIGKRDDDRLIFVQSAKTTQHLLMFTSLGNVIYRPIHELA
                     DIRWKDIGEHLSQTITNFETNEAILYVEVLDQFDDATTYFAATRLGQIKRVERKEFTP
                     WRTYRSKSVKYAKLKDDTDQIVAVAPIKLDDVVLVSQNGYALRFNIEEVPVVGAKAAG
                     VKAMNLKEDDVLQSGFICNTSSFYLLTQRGSLKRVSIEEILATSRAKRGLQVLRELKN
                     KPHRVFLAGAVAEQGFVGDFFSTEVDVNDQTLLVQSNKGTIYESRLQDLNLSERTSNG
                     SFISDTISDEEVFDAYLQEVVTEDK"
     gene            5757..6779
                     /locus_tag="AC0DU4_000289"
     CDS             5757..6779
                     /locus_tag="AC0DU4_000289"
                     /EC_number="2.6.1.42"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004084 - branched-chain-amino-acid
                     transaminase activity [Evidence IEA];
                     GO_process: GO:0009081 - branched-chain amino acid
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="HIN4236320.1"
                     /translation="MTVTIDWENLGFSYMKLPYRYLAHFKNGQWDQGELTEDATLHIS
                     ESSPSLHYGQQAFEGLKAYRTKDGSVQLFRPDENAKRLQRTCDRLLMPQVPTDMFVEA
                     CKAVVRANEEYVPPYGIGGTLYLRPLLIGVGDIIGVKPAEEYIFTIFAMPVGNYFKGG
                     LVPTNFLIQDEYDRAAPNGTGAAKVGGNYAASLLPGKMAKSRHFSDVIYLDPSTHTKI
                     EEVGSANFFGITADNEFVTPLSPSILPSITKYSLLYLAEHRLGLTPIEGDVPIDNLDR
                     FVEAGACGTAAVISPIGGIQHGDDFHVFYSETEVGPVTRKLYNELTGIQFGDIEAPEG
                     WIVKVD"
     gene            6835..7539
                     /locus_tag="AC0DU4_000290"
     CDS             6835..7539
                     /locus_tag="AC0DU4_000290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4236321.1"
                     /translation="MVLSTLAILVACGKTDKEADAPTTFSYVYAVDPASLGYSITTRT
                     STTDVIGNVIDGLMENDKYGNVAPSQKDYDLNSTGWAPSYQDPASYLNIMDPKSGSAM
                     KHLGITKGKDKDVVAKPGLDKYKKLLEDAVSETTDLEKRYEKYAKAQAWSTDSSLLMP
                     TASSGGSPIVSNVVPFSKPYSQVGIKGEPYIFKGMKLQKDIVTTKEYNEVFKKWQKEK
                     LESNSKYQKELEKHIK"
     gene            7604..8293
                     /locus_tag="AC0DU4_000291"
     CDS             7604..8293
                     /locus_tag="AC0DU4_000291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF969 domain-containing protein"
                     /protein_id="HIN4236322.1"
                     /translation="MEWIRLIGIAIIVVGFILKFDTIATVVLAGLVTALVSGVSLVEF
                     LEILGKEFSNQRVLTIFMVTLPLVGLSETFGLKQRSIDLIRKIKGLTVGNFYTVYFFI
                     RELAGFFSIRLGGHPQFVRPLVQPMGEAAAESQLGRKLTEVEDETIKARAAANENFGN
                     FFAQNTFVGAGGVLLIGGTLDQLGYESNYAGIASTSIIVAVITLIVVGIYNYLFDKKL
                     ISKKTRGGEQK"
     gene            8290..9213
                     /locus_tag="AC0DU4_000292"
     CDS             8290..9213
                     /locus_tag="AC0DU4_000292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF979 domain-containing protein"
                     /protein_id="HIN4236323.1"
                     /translation="MTELAKQLLELTYIVIGCQFLHTAYCSYKDKTNPVRLGTSAFWT
                     LLSITFIGGSYMPNMSIGIIVILLSLLTLFKQVRIGTLPSLDEMKANIESNRLKNKIF
                     IPVMLMAILALVLAQMIPEFSKISISLAALFATISVLVITNSHPKSLLSENNRMTQQV
                     STSGIVPQLLGALGAIFTVAGVGDVISHLISGIVPSDSRFIGVLAYVLGMVLFTMIMG
                     NAFAAFTVITAGVGVPFVFALGANPIVAGALAMTAGYCGTLLTPMAANFNALPAALMD
                     MKDQNGVIKAQAGVALVMIVIHIFLMYFLAF"
     gene            9228..9872
                     /gene="pcp"
                     /locus_tag="AC0DU4_000293"
     CDS             9228..9872
                     /gene="pcp"
                     /locus_tag="AC0DU4_000293"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0008234 - cysteine-type peptidase activity
                     [Evidence IEA];
                     GO_function: GO:0016920 - pyroglutamyl-peptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HIN4236324.1"
                     /translation="MKILVTGFNPFGGEKINPALEAVKLLPSEINGAEVRWVEIPTVF
                     YKSSEVLEAEILRYQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPI
                     RIDGASAYFSSLPIKAMVQAIKKQGLPAVVSNSAGTFVCNHLMYQALYLVDKKFPNMR
                     AGFMHIPYMMEQVVNKPNTAGMSLCDIVRGIEVAIEAIVDYKDKDLQLVGGETH"
     gene            10040..10270
                     /locus_tag="AC0DU4_000294"
     CDS             10040..10270
                     /locus_tag="AC0DU4_000294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000037109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2969 domain-containing protein"
                     /protein_id="HIN4236325.1"
                     /translation="MSKKDKKIEIQVADAKVNVGKDSFEGYTLTIGKKVIGEIAELDG
                     QFAIIKNGNVDSFYKKLEKAVEILIENYNLAK"
     gene            10320..10400
                     /locus_tag="AC0DU4_000295"
     tRNA            10320..10400
                     /locus_tag="AC0DU4_000295"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:10354..10356,aa:Tyr,seq:gta)
     gene            10410..10481
                     /locus_tag="AC0DU4_000296"
     tRNA            10410..10481
                     /locus_tag="AC0DU4_000296"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:10442..10444,aa:Gln,seq:ttg)
     gene            10643..11845
                     /gene="rpsA"
                     /locus_tag="AC0DU4_000297"
     CDS             10643..11845
                     /gene="rpsA"
                     /locus_tag="AC0DU4_000297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S1"
                     /protein_id="HIN4236326.1"
                     /translation="MNEFEDLLNSVSQVETGDVVSAEVLTVDATQANVAISGTGVEGV
                     LTLRELTNDRDADINDFVKVGEVLDVLVLRQVVGKDTDTVTYLVSKKRLEARKAWDKL
                     VGREEEVVTVKGTRAVKGGLSVEFEGVRGFIPASMLDTRFVRNAERFVGQEFDTKIKE
                     VNAKENRFILSRREVVEAATAAARAEVFGKLAVGDVVTGKVARITSFGAFVDLGGVDG
                     LVHLTELSHERNVSPKSVVTVGEEIEVKILDLNEEEGRVSLSLKATVPGPWDGVEQKL
                     AKGDVVEGTVKRLTDFGAFVEVLPGIDGLVHVSQISHKRIENPKEALKVGQEVQVKVL
                     EVNADAERVSLSIKALEERPAQEEGQKEEKRVARPRRPRRQEKRDFELPETQTGFSMA
                     DLFGDIEL"
     gene            complement(11931..12305)
                     /locus_tag="AC0DU4_000298"
                     /pseudo
     CDS             complement(11931..12305)
                     /locus_tag="AC0DU4_000298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            12547..13044
                     /locus_tag="AC0DU4_000299"
     CDS             12547..13044
                     /locus_tag="AC0DU4_000299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GAF domain-containing protein"
                     /protein_id="HIN4236327.1"
                     /translation="MLKSEKQSRYQMLNEELSFLLEGETNVLANLSNASALIKSRFPN
                     TVFAGFYLFDGKELVLGPFQGGVSCIRIALGKGVCGEAAHFQETVIVGDVTTYLNYIS
                     CDSLAKSEIVVPMMKNGQLLGVLDLDSSEIEDYDAMDRDYLEQFVAILLEKTTWDFTM
                     FEEKS"
     gene            13044..14699
                     /gene="dnaX"
                     /locus_tag="AC0DU4_000300"
     CDS             13044..14699
                     /gene="dnaX"
                     /locus_tag="AC0DU4_000300"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009360 - DNA polymerase III complex
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HIN4236328.1"
                     /translation="MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSG
                     PRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQAVTDGSLEDVIEMDAASNNGVDE
                     IREIRDKSTYAPSLARYKVYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHK
                     IPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALS
                     ILDQALSLTQGNELTTAISEEITGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGK
                     SMTRFVTDLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLFEMIRLATVSLADIK
                     SSLQPKIYAEMMTVRLAEIKPEPALSGAVENEIATLRQEVARLKQELSNVGAVPKQVA
                     PAPSRPATGKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKA
                     LLVGSQPVAANEHHAILAFESNFNAGQTMKRDNLNTMFGNILSQAAGFSPEILAISME
                     EWKEVRAAFSAKAKSSQTEKEVEESLIPEGFEFLADKVKVEED"
     gene            14727..14921
                     /locus_tag="AC0DU4_000301"
     CDS             14727..14921
                     /locus_tag="AC0DU4_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3272 domain-containing protein"
                     /protein_id="HIN4236329.1"
                     /translation="MNKQQFIIMALFTAAETYFFNEAWMTGRYIMAAFWAILLFRNFR
                     VSYVMGKIVDVIDQHFNRKD"
     gene            15071..15841
                     /gene="sufC"
                     /locus_tag="AC0DU4_000302"
     CDS             15071..15841
                     /gene="sufC"
                     /locus_tag="AC0DU4_000302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000114488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly ATPase SufC"
                     /protein_id="HIN4236330.1"
                     /translation="MSVLEIKDLHVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKST
                     LSAAIMGNPNYEVTKGEVLFDGVNILELEVDERARMGLFLAMQYPSEIPGITNAEFLR
                     AAMNAGKEDDEKISVREFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEILQLL
                     MLEPTFALLDEIDSGLDIDALKVVSKGVNAMRGEGFGAMIITHYQRLLNYITPDVVHV
                     MMEGRVVLSGGPELAARLEREGYAKLAEELGYDYKEEL"
     gene            15869..17131
                     /gene="sufD"
                     /locus_tag="AC0DU4_000303"
     CDS             15869..17131
                     /gene="sufD"
                     /locus_tag="AC0DU4_000303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufD"
                     /protein_id="HIN4236331.1"
                     /translation="MTRENIKLFSEMHAEPSWLADLRQKAFDKIETLELPVIERVKFH
                     RWNLGDGTITENEPSANVPDFTALDHHLKLVQVGTQTVFEQTPVELAEQGVVFTDFHS
                     ALEEIPELIEEFFMSSVKYDDDKLAAYHTAYFNSGAVLYIPDNVEITEPIEGIFYQDS
                     DSNVPFNKHIMIIAGKNSKISYLERLESRGEGSDKVTANITVEVIARSGAQVKFAAID
                     RLGENVTAYISRRGKLGNDASIDWAIGVMNEGNVVADFDSDLIGNGSHADLKVVALSS
                     GRQVQGIDTRVTNYGCNSIGNILQHGVILEKATLTFNGIGHIIKGAKGADAQQESRVL
                     MLSDQARSDANPILLIDENDVTAGHAASIGQVDPEDMYYLMSRGLDKATAERLVVRGF
                     LGSVIVEIPVKEVRDEMIATIEEKLSKR"
     gene            17142..18368
                     /locus_tag="AC0DU4_000304"
     CDS             17142..18368
                     /locus_tag="AC0DU4_000304"
                     /EC_number="2.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000887707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_function: GO:0031071 - cysteine desulfurase activity
                     [Evidence IEA];
                     GO_process: GO:0006534 - cysteine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HIN4236332.1"
                     /translation="MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINS
                     YYEQDNANVHRGVHTLAERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVAR
                     FAEEILTEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTD
                     KVKFVSLAHASNVLGVINPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFA
                     FSGHKMAGPTGIGVLYGKEKYLEQMSPVEFGGEMIDFVYEQFASWKELPWKFEAGTPN
                     MAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVI
                     AFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDK
                     LVDALQKTKEFFNGTF"
     gene            18355..18795
                     /gene="sufU"
                     /locus_tag="AC0DU4_000305"
     CDS             18355..18795
                     /gene="sufU"
                     /locus_tag="AC0DU4_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005198 - structural molecule activity
                     [Evidence IEA];
                     GO_process: GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly sulfur transfer protein
                     SufU"
                     /protein_id="HIN4236333.1"
                     /translation="MALSKLDSLYMAVVADHSKNPHHQGKLEDAEQISLNNPTCGDVI
                     NLSVKFDAEDRLEDIAFLNSGCTISTASASMMTDAVLGKTKQEILELATIFSEMVQGQ
                     KDERQGQLGDAAFLSGVAKFPQRIKCATLAWNALKKTIENQEKQ"
     gene            18849..20261
                     /gene="sufB"
                     /locus_tag="AC0DU4_000306"
     CDS             18849..20261
                     /gene="sufB"
                     /locus_tag="AC0DU4_000306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufB"
                     /protein_id="HIN4236334.1"
                     /translation="MAEERVEPKPIDLGEYKFGFHDDVEPVLSTGKGLNEGVIRELSA
                     AKGEPEWMLEFRLKSYETFKKMPMQTWGADLSEIDFDDLIYYQKPSDKPARSWDDVPE
                     KIKETFERIGIPEAERAYLAGASAQYESEVVYHNMKEEFQKLGIIFTDTDSALKEYPD
                     LFKQYFAKLVPPTDNKLAALNSAVWSGGTFIYVPKGVKVDIPLQTYFRINNENIGQFE
                     RTLIIVDEGASVHYVEGCTAPTYSSNSLHAAIVEIFALDGAYMRYTTIQNWSDNVYNL
                     VTKRAKAQKDATVEWIDGNLGAKTTMKYPSVYLDGEGARGTMLSIAFANAGQHQDTGA
                     KMIHNAPHTSSSIVSKSIAKGGGKVDYRGQVTFNKNSKKSVSHIECDTIIMDDLSASD
                     TIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKELP
                     MEYAVELNRLISYEMEGSVG"
     gene            complement(20492..21733)
                     /gene="pbp3"
                     /locus_tag="AC0DU4_000307"
     CDS             complement(20492..21733)
                     /gene="pbp3"
                     /locus_tag="AC0DU4_000307"
                     /EC_number="3.4.16.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase PBP3"
                     /protein_id="HIN4236335.1"
                     /translation="MKKIFLTLLTVSLLGGASTAVAQDFTIAAKHAIAVEANTGKILY
                     EKDATQPVEIASITKLITVYLVYEALENGSITLSTPVDISDYPYQLTTNSEASNIPME
                     ARNYTVEELLEATLVSSANSAAIALAEKIAGSEKDFVDMMRAKLLEWGIQDATVVNTT
                     GLNNETLGDNIYPGSKKDEENKLSAYDVAIVARNLIKKYPQVLEITKKPSSTFAGMTI
                     TSTNYMLEGMPAYRGGFDGLKTGTTDKAGESFVGTTVEKGMRVITVVLNADHQDNNPY
                     ARFTATSSLMDYISSTFTLRKIVQQGDAYQDSKTPVQDGKEDTVTAVAPEDIYLIERV
                     GNQSSQSVQFTPDSKAIPAPLEAGTVVGHLTYEDKDLIGQGYITTERPSFEMVADKKI
                     EKAFFLKVWWNQFVRFVNEKL"
     gene            21836..22945
                     /gene="cozE"
                     /locus_tag="AC0DU4_000308"
     CDS             21836..22945
                     /gene="cozE"
                     /locus_tag="AC0DU4_000308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell elongation protein CozE"
                     /protein_id="HIN4236336.1"
                     /translation="MFRRNKLFFWTTEILLLTIIFYLWRQMGSLINPFVSVLNTIMIP
                     FLLGGFLYYLTNPIVTFLNKVCKLNRLLGILITLCTLVWGMVIGVVYLLPILINQLSS
                     LIISSQTIYSRVQDLIIDLSNYPALQNLDVEATIQQLNLSYVDILQNILNSVSNSVGS
                     VLSALISTVLILIMTPVFLVYFLLDGHKFLPMLERTILKRDRLHIAGLLKNLNATIAR
                     YISGVSIDAIIIGCLAYIGYSIIGLKYALVFAIFSGVANLIPYVGPSIGLIPMIIANI
                     FTDPHRLLIAVIYMLVVQQVDGNILYPRIVGSVMKVHPITILVLLLLSSNIYGVVGMI
                     VAVPTYSILKEISKFLSRLYENHKIMKERERELAK"
     gene            23479..23826
                     /gene="ssrA"
                     /locus_tag="AC0DU4_000309"
     tmRNA           23479..23826
                     /gene="ssrA"
                     /locus_tag="AC0DU4_000309"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            complement(23999..24086)
                     /locus_tag="AC0DU4_000310"
     tRNA            complement(23999..24086)
                     /locus_tag="AC0DU4_000310"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(24050..24052),aa:Ser,seq:gga)
     gene            24249..24989
                     /locus_tag="AC0DU4_000311"
     CDS             24249..24989
                     /locus_tag="AC0DU4_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="HIN4236337.1"
                     /translation="MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELE
                     AENKLRRVHGGAELPHSLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGT
                     TTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQIN
                     QLHFDRAFIGMNGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVA
                     PLKRAIVITSQGHELLQVIKEKTEVIEV"
     gene            24986..25897
                     /gene="pfkB"
                     /locus_tag="AC0DU4_000312"
     CDS             24986..25897
                     /gene="pfkB"
                     /locus_tag="AC0DU4_000312"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015605104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008662 - 1-phosphofructokinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HIN4236338.1"
                     /translation="MIYTVTLNPSIDYIVRLDQVKVGSVNRMDSDDKFAGGKGINVSR
                     VLKRLNIPNTATGFIGGFTGKFITDTLAEEEIETRFVQVAEDTRINVKIKADQETEIN
                     GTGPTVEPVQLEELKAILSSLTVEDTVVFAGSSAKNLGNVIYKDLISLTRQTGAQVVC
                     DFEGQTLIDSLDYQPLLVKPNNHELGAIFGVKLESLDEIEKYARELLAKGAQNVIISM
                     AGDGALLVTSEGAYFAKPIKGTVKNSVGAGDSMVAGFTGEFVKSKDAVEAFKWGVACG
                     TATTFSDDLATAEFIKETYGKVEVEKR"
     gene            25894..27846
                     /locus_tag="AC0DU4_000313"
     CDS             25894..27846
                     /locus_tag="AC0DU4_000313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022877 -
                     protein-N(PI)-phosphohistidine-fructose phosphotransferase
                     system transporter activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-specific PTS transporter subunit EIIC"
                     /protein_id="HIN4236339.1"
                     /translation="MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTEHGYVTDFETF
                     KEGILAREALTSTGLGDGIAMPHSKNAAVKEATVLFAKSNKGVDYESLDGQATDLFFM
                     IAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSAGQVIELFDQASEKTEELVQAP
                     ANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDI
                     RKAKAIIIAADKAVEMDRFDGKPLINRPVADGIRKTEELINLALSGDTEVYRAANGAK
                     AATASNEKQSLGGALYKHLMSGVSQMLPFVIGGGIMIALAFLIDGALGVPNENLGNLG
                     SYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIP
                     YAAGGEATSTLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLG
                     TILTGFVMLAVNIPMAAINTAMNDFLGGLGGGSAVLLGIVLGGMMAVDMGGPVNKAAY
                     VFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLFKDKFTKEERNSGLTNIIM
                     GLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNA
                     LLYLVSVLVGAIVSGVVYGYLRKPQA"
     gene            27983..30235
                     /locus_tag="AC0DU4_000314"
     CDS             27983..30235
                     /locus_tag="AC0DU4_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HIN4236340.1"
                     /translation="MERKEAIQRMLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGS
                     LAYLAIFGLLIYLFFFKWIRKQEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGT
                     MAQVVTDLTGFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGSILILVGSLLVSPWS
                     VYDIAEFFSRGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETEKTLLDLPP
                     VDMETGEILTEEAVQNLPPIPEEKWVEPEIILPQAELKFPEQEDDSDDEDVQVDFSAK
                     EALEYKLPSLQLFAPDKPKDQSKEKKIVRENIKILEATFASFGIKVTVERAEIGPSVT
                     KYEVKPAVGVRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDIATVSFR
                     ELWEQSQTKAENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASI
                     LMKARPDQVKFMMVDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYEL
                     FAKVGVRNIAGFNAKVEEFNSQSEYKQIPLPFIVVIVDELADLMMVASKEVEDAIIRL
                     GQKARAAGIHMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLL
                     GRGDMLFKPIDENHPVRLQGSFISDDDVERIVNFIKAQADADYDESFDPGEVSENEGE
                     FSDGDAGGDPLFEEAKSLVIETQKASASMIQRRLSVGFNRATRLMEELEIAGVIGPAE
                     GTKPRKVLQQ"
     gene            complement(30280..30708)
                     /locus_tag="AC0DU4_000315"
     CDS             complement(30280..30708)
                     /locus_tag="AC0DU4_000315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6556 family protein"
                     /protein_id="HIN4236341.1"
                     /translation="MSNYRRTSKPKTEHIKKGFTVFQKTVATIASILGLITAGITIMN
                     ALDNNKNIKKEPTTSQTTTIVKEIQKESPKENTSPTKETNTSQEKTQQEETPKSSVKE
                     EKKEDQKTATQDSSTPASSKPATENEKQSNAPTSENKSNQ"
     gene            30846..31988
                     /locus_tag="AC0DU4_000316"
     CDS             30846..31988
                     /locus_tag="AC0DU4_000316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase family protein"
                     /protein_id="HIN4236342.1"
                     /translation="MIYFDNSATTRPYPEALETYMQVASKILGNPSSLHRLGDQATRI
                     LDASRQQIADLIGKKSDEIFFTSGGTEGDNWIIKGVAFEKAQFGKHIIVSAIEHPAVK
                     ESALWLKAQGFEVDFAPVDNKGFVDVEALEDLIRPDTTLVSIMAVNNEIGSVQPIEAI
                     SKLLADKPTISFHVDAVQALAKIPTEKYLTERVDFATFSGHKFHGIRGVGFIYIKSGK
                     KITPLLTGGGQERDYRSTTENVAGIAATAKALRLSMEKLDIFRSKTGQMKAVIRQALL
                     DYPDIFVFSDEEDFAPHILTFGIKGVRGEVIVHAFEDYDIFISTTSACSSKAGKPAGT
                     LIAMGVDKDKAQSAVRLSLDLENDMSQVEQFLTKLKLIYNQTRKVR"
     gene            31997..33211
                     /gene="thiI"
                     /locus_tag="AC0DU4_000317"
     CDS             31997..33211
                     /gene="thiI"
                     /locus_tag="AC0DU4_000317"
                     /EC_number="2.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001200101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0140741 - tRNA-uracil-4 sulfurtransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uracil 4-sulfurtransferase ThiI"
                     /protein_id="HIN4236343.1"
                     /translation="MQYSEIMIRYGELSTKGKNRMRFINKLRNNISDVLSIYPQVKVT
                     ADRDRAHAYLNGADYTAVAESLKQVFGIQNFSPVYKVEKSVEVLKSAVQEIMQDIYKE
                     GMTFKISSKRSDHTFELDSRELNQTLGRAVFEAIPNVQAQMKSPDINLQVEIREEAAY
                     LSYETVRGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGVDIEAVHFASPPYTSPG
                     ALKKAQDLTRKLTKFGGNIQFIEVPFTEIQEEIKAKAPEAYLMTLTRRFMMRITDRIR
                     EVRNGLVIINGESLGQVASQTLESMKAINAVTNTPIIRPVVTMDKLEIIDIAQEIDTF
                     DISIQPFEDCCTIFAPDRPKTNPKIKNAEQYEARMDVEGLVERAVAGIMITEITPQAE
                     KDEVDDLIDNLL"
     gene            33346..34169
                     /locus_tag="AC0DU4_000318"
                     /pseudo
     CDS             33346..34169
                     /locus_tag="AC0DU4_000318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076725.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
     gene            34191..34930
                     /locus_tag="AC0DU4_000319"
                     /pseudo
     CDS             34191..34930
                     /locus_tag="AC0DU4_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546805.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
     gene            34943..36109
                     /locus_tag="AC0DU4_000320"
     CDS             34943..36109
                     /locus_tag="AC0DU4_000320"
                     /EC_number="6.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001108652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HIN4236344.1"
                     /translation="MNYLVISPYYPQNFQQFTIELANKGITVLGIGQESYEQLDEPLR
                     NSLTEYFRVDNLENIDEVKRAVAFLFYKHGPIDRIESHNEYWLELDATLREQFNVFGA
                     KPEDLKKTKYKSEMKKLFKKAGVPVVPGAVIKTEADVDQAVKEIGLPMIAKPDNGVGA
                     ATTFKLETEDDINHFKQEWDHSTLYFFEKFVTSSEICTFDGLVDKDGKIVFSTTFDYA
                     YTPLDLMIYKMDNSYYVLKDMDPKLRKYGEAIVKEFGMKERFFHIEFFREGDDYITIE
                     YNNRPAGGFTIDVYNFAHSLDLYRGYAAIVAGEEFPASDFETQYCLATSRRANAHYVY
                     SEEDLLAKYSQQFKVKKVMPAAFAELQGDYLYMLTTPSRQEMEQMIADFGQRQE"
     gene            36369..36494
                     /locus_tag="AC0DU4_000321"
     CDS             36369..36494
                     /locus_tag="AC0DU4_000321"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236345.1"
                     /translation="MKIKEQTRKLAAGFSKHCFEVVDRTDRVSIIYLRQGEADVV"
     gene            36617..38110
                     /locus_tag="AC0DU4_000322"
     CDS             36617..38110
                     /locus_tag="AC0DU4_000322"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I restriction-modification system subunit
                     M"
                     /protein_id="HIN4236346.1"
                     /translation="MITGELKNKIDQLWEILWTEGNANPLTNIEQLTYLLFMKDLDSV
                     ELGRESDAEFLGIPYEGVFPKDKPEYRWSTFKNIGDAQEVYRLMTQEIFPFIKNLKGD
                     TDDTAFSRYMREAIFQINKPATLQKAISILDVFPTRGLDVDFDNDKQSITDIGDIYEY
                     LLSKLSTAGKNGQFRTPRHIIDMMVELMQPTIKDIISDPAMGSAGFLVSASRYLKRKK
                     DEWETNTDNINHFHNQMFHGNDTDTTMLRLGAMNMMLHGVENPQISYLDSLSQDNEEA
                     DKYTLVLANPPFKGSLDYNSTSNDLLATVKTKKTELLFLSLFLRTLKPGGRAAVIVPD
                     GVLFGSSKAHKGIRQEIVENHKLDAVISMPSGVFKPYAGVSTAILIFTKTGNGGTDKV
                     WFYDMKADGLSLDDKRQPISDNDIPDIIERFHHLEKEAERQRTDQSFFVPVAEIKEND
                     YDLSINKYKEIEYEKVEYEPTEVILKKINDLEKEIQAGLAELEKLLK"
     gene            38123..39188
                     /locus_tag="AC0DU4_000323"
                     /pseudo
     CDS             38123..39188
                     /locus_tag="AC0DU4_000323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756164.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
     gene            39248..39484
                     /locus_tag="AC0DU4_000324"
     CDS             39248..39484
                     /locus_tag="AC0DU4_000324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000260605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbrB family transcriptional regulator"
                     /protein_id="HIN4236347.1"
                     /translation="MVVKTRKQGNSITITIPSEFNIPSGVKYEAKLLPSGEIIFTPEE
                     LGQQVSYVSDDAFDLNLDKIFDEYDDVFKALVEK"
     gene            39481..39894
                     /locus_tag="AC0DU4_000325"
     CDS             39481..39894
                     /locus_tag="AC0DU4_000325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000158364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_function: GO:0090729 - toxin activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system death-on-curing
                     family toxin"
                     /protein_id="HIN4236348.1"
                     /translation="MTIYLTEKQIEKINALAIQRYSPNEKIQTVSSSALNMIVNLPEQ
                     FVFGKSLYPTIFDKATILFVQLIKKHVFANANKRTAFFVLVKFLQLNGYRFSVTVEEA
                     VKMCVTIAVEALTDEKMTSYSKWVSEHSVREKVKK"
     gene            40012..40977
                     /gene="xerA"
                     /locus_tag="AC0DU4_000326"
     CDS             40012..40977
                     /gene="xerA"
                     /locus_tag="AC0DU4_000326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008907 - integrase activity [Evidence
                     IEA];
                     GO_function: GO:0009037 - tyrosine-based site-specific
                     recombinase activity [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific tyrosine recombinase/integron
                     integrase"
                     /protein_id="HIN4236349.1"
                     /translation="MESKVTIIMQEMLPLLNNEQLLALRESLEHHLVDGKKQQKYSNN
                     NLLQLFITAKQVEGCSSKTIRYYQRTIENLFNAIKESVTQLTTDDLRSYLANYQSEKD
                     CSKANLDNIRRILSSFFAWLEQEEYIIKNPIRRIKKIKTEQNVKETYTDEHLEIMRDN
                     CENLRDLAIIDLLASTGMRVGELVQLNRSDIDFENRECVVFGKGKKERPVYFDARTKI
                     HLRNYLNDRKDSHPALFVTLVGKAQRLGIAGVEIRLRKLGDKLGIQKVHPHKFRRTLA
                     TKAIDKGMPIEQVQKLLGHSKIDTTLAYAMVNQNNVKHSHQKFIS"
     gene            41000..41581
                     /locus_tag="AC0DU4_000327"
     CDS             41000..41581
                     /locus_tag="AC0DU4_000327"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HIN4236350.1"
                     /translation="MFGENKIFESIDNLFDIIDGDRGKNYPKSDELFSEEYCLFLNTK
                     NVTKNGFSFDTKQFITKTKDKLLRKGKLERYDIVLTTRGTVGNVAYYDELIKYKHLRI
                     NSGMVILRPKTPNLNQKFIIHVLRNNNYSRVISGSAQPQLPITKLKKILLPLPPLALQ
                     NEFADFVVQVDKSQFACEIAIKVWRNSLKFSII"
     gene            41611..44961
                     /locus_tag="AC0DU4_000328"
     CDS             41611..44961
                     /locus_tag="AC0DU4_000328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000526318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HIN4236351.1"
                     /translation="MGNFSFLLKNDEYESFSKPCIEAENMIATSTVATAFMARRALEQ
                     AVHWIYSHDSYLEAPYRATLSSLVWDDDFRDIVDSELHKQIVLLIRWGNHAAHGGEIK
                     EREAILALHHLYQFVNFIDYCYSNEFVERYFDEKCLPLSANIKYRETPQSMIKLQDSL
                     PELPDFHEQMAAQSVEVQETYTEKRETAAQRQDVPFHIDQLSEAETRKLFIDIDLRLA
                     GWIFEENCRVEIAVDGLKHGSGIGYCDYVLYGKNGKILAIVEAKKASVNPEVGEVQVK
                     EYAEALEKHIGYQPICFITNGLKHYILDGPNRRQIAGFYSQEELQLVMDRRHLQKPLE
                     DISSKIRDDISGRHYQKHAIASVCEAFSNHRRQALLVMATGAGKTRTAVSLVDILSRH
                     NWVKNVLFLADRTSLVKQAYDSFRKLLPDLSVCNFLEDKEGAQSSRMVFSTYPTMIGA
                     ISGQEEVNQRPFTVGHFDLIIIDESHRSIYQKYKSIFDYFDARIVGLTATPRQDLDKN
                     TYGFFNLENGVPTYAYDLEEAVKDGYLVAYHSIETKLKLPTDGLHYDDLSEEEKEHFD
                     SKFEDDSCEKDIDGSVFNSFIFNKSTVEIVLNELMTRGIQTASGDEIGKTIIFAKNHD
                     HAEYIRGIFNNRYPEKGSDYAQVIDYSIKHYQTLIDDFKIKEKYPQIAISVDMLDTGI
                     DVPEVVNLVFFKKVRSKTKFWQMIGRGTRLCKDLFGPEQDKENFLVFDYGDNFDYFRA
                     DPRDGEGRHIVSLTQRLFNIKVDLIRELQGLQYQEDQFARAYRQQLVSELQGRIESLN
                     ELDFRVRMVLDTVYSYKKLESWQNLTAVTSETIQKNLSPLLFDEDKEDEMARRFDLWL
                     LHIQLGQLTAKSSTVHISQVMKTARALSAIGNIPQVFEQAEIIRKVQEPEFWKEVNLS
                     DLEKIRLAIRDLLQFLDKTDRKPYYVNFEDRILSTVHETTAFLQVNDLRSYNEKVEQY
                     LKTHLDEESISKLYHNKKLTSDDMLALEKLLWEKLGSKADYQSHYENKAIPRLVREII
                     GLDRESANRIFSKFLSDENLNARQISFVKLIVDYIVENGFLETKVLTQEPFKSYGSVQ
                     LLFQHQLPVLRNIVQIIELINNRAGEAA"
     gene            45232..45432
                     /locus_tag="AC0DU4_000329"
     CDS             45232..45432
                     /locus_tag="AC0DU4_000329"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236352.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDKTDEVSSKHGFEVVDETDEVS
                     NHIYGKATLTRIEEIFEEYKSS"
     gene            complement(45549..46019)
                     /locus_tag="AC0DU4_000330"
     CDS             complement(45549..46019)
                     /locus_tag="AC0DU4_000330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001043003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HIN4236353.1"
                     /translation="MNKSEHRHQLIRALITKNKIHTQAELQALLAENDIQVTQATLSR
                     DIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELYMEDALVWMRPVQHQVLLKTLPGL
                     AQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEE"
     gene            complement(46036..48309)
                     /locus_tag="AC0DU4_000331"
     CDS             complement(46036..48309)
                     /locus_tag="AC0DU4_000331"
                     /EC_number="3.4.14.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008239 - dipeptidyl-peptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Xaa-Pro dipeptidyl-peptidase"
                     /protein_id="HIN4236354.1"
                     /translation="MRFNQYSYINFPKENVLSELKKCGFDLQNTANHKDSLETFLRRF
                     FFTYQDTNYPLSILAADKKTDLLTFFQSEDELTADIFYTVAFQLLGFSYLVDFEDSDV
                     FRKETGFPIIYGDLIENLYQLLNTRTKKGNTLIDQLVSDGLIPEDNDYHYFNGKSLAT
                     FSNQDVIREVVYVESRVDTDQKGLSDLVKVSIIRPRFDGKIPAIMTASPYHQGTNDKA
                     SDKALYKMEGELEVKLPHKIELEKPQLNLVQPQGKAELIAEAEEKLTHINSSYTLNDY
                     FLPRGFANLYVSGVGTKDSTGFMTNGDYQQIEAYKNVIDWLNGRCRAFTDHTRQRQVK
                     ADWSNGKVATTGLSYLGTMSNGLATTGVDGLEVIIAEAGISSWYNYYRENGLVTSPGG
                     YPGEDFDSLAELTYSRNLLAGDYIRGNEAHQADLEKVKAQLDRKTGDYNQFWHDRNYL
                     LNAHKVKAEVVFTHGSQDWNVKPLHVYQMFHALPTHIHKHLFFHNGAHVYMNNWQSID
                     FRESINALLTKKLLGQETDFQLPTVIWQDNTAPQTWLSLDNFGGQENCETFSLGQEEQ
                     AIQNQYPDKDFERYGKTYQIFNTELYQGKANQITINLPVTKDLHLNGRAQLNLRIKSS
                     TNKGLLSAQLLEFGQNKYLQPYPAILSARTIDNGRYHMLENLCELPFRPEAQRVVTKG
                     YLNLQNRNDLLLVEDITADEWMDVQFELQPTIYKLKEGDTLRLVLYTTDFEITIRDNT
                     DYHLTVDLAQSMLTLPC"
     gene            48656..51757
                     /locus_tag="AC0DU4_000332"
     CDS             48656..51757
                     /locus_tag="AC0DU4_000332"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000561528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HIN4236355.1"
                     /translation="MIAQLDTKTVYSFMESVISIEKYVRAAKEYGYTHLAMMDIDNLY
                     GAFDFLEITKKYGIHPLLGLEMTVFVDDQEVNLRFLALSSVGYQQLMKLSTAKMQGEK
                     TWSVLSQYLEDIAVIVSYFDRVESLELGCDYYIGVYPETLASEFHHPILPLYRVNAFE
                     SRDREVLQVLTAIKENLPLREVPLRSRQDVFISASSLEKLFQERFPQALDNLEKLISG
                     ISYDLDTSLKLPRFNPARPAVEELRERAELGLVQKGLTSKEYQDRLDQELSVIHDMGF
                     DDYFLVVWDLLRFGRSNGYYMGMGRGSAVGSLVSYALDITGIDPVEKNLIFERFLNRE
                     RYTMPDIDIDIPDIYRPDFIRYVGNKYGSKHAAQIVTFSTFGAKQALRDVLKRFGVPE
                     YELSAITKKISFRDNLKSAYEGNLQFRQQINSKLEYQKAFEIACKIEGYPRQTSVHAA
                     GVVISDQDLTNYIPLKYGDEIPLTQYDAHGVEASGLLKMDFLGLRNLTFVQKMQELLA
                     EIEGIHLKIEEIDLEDKETLDLFASGNTKGIFQFEQPGAIRLLKRVQPVCFEDVVATT
                     SLNRPGASDYINNFVARKHGQEEVTVLDPVLEDILAPTYGIMLYQEQVMQVAQRFAGF
                     SLGKADILRRAMGKKDASAMHEMRVSFIQGSLEAGHTVEKAEQVFDVMEKFAGYGFNR
                     SHAYAYSALAFQLAYFKTHYPAIFYQVMLNSSNSDYLIDALEAGFEVASLSINTIPYH
                     DKIANKAIYLGLKSIKGVSNDLALWIIENRPYSNIEDFIAKLPENYLKLPLLEPLVKV
                     GLFDSFEKNRQKVFNNLANLFEFVKELGSLFGDAIYSWQESEDWTEQEKFYMEQELLG
                     IGVSKHPLQAIASKAIYPITPIGNLSENSYAIILVEVQKIKVIRTKKGENMAFLQADD
                     SKKKLDVTLFSDLYRQVGQEIKEGAFYYVKGKIQSRDGRLQMIAQEIREAVAERFWIQ
                     VKNHESDQEISRILEQFKGPIPVIIRYEEEQKTIVSPHHFVAKSNELEEKLNEIVMKT
                     IYR"
     gene            51840..52847
                     /gene="pfkA"
                     /locus_tag="AC0DU4_000333"
     CDS             51840..52847
                     /gene="pfkA"
                     /locus_tag="AC0DU4_000333"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HIN4236356.1"
                     /translation="MKRIAVLTSGGDAPGMNAAIRAVVRQAISEGMEVFGIYDGYAGM
                     VAGEIHPLDAASVGDIISRGGTFLHSARYPEFAQLEGQLKGIEQLKKHGIEGVVVIGG
                     DGSYHGAMRLTEHGFPAIGLPGTIDNDIVGTDFTIGFDTAVTTAMDAIDKIRDTSSSH
                     RRTFVIEVMGRNAGDIALWAGIATGADEIIIPEAGFKMEDIVASIKAGYECGKKHNII
                     VLAEGVMSADEFGQKLKEAGDTSDLRVTELGHIQRGGSPTARDRVLASRMGAHAVKLL
                     KEGIGGVAVGIRNEKMVENPILGTAEEGALFSLTAEGKIVVNNPHKADIELSSLNKSL
                     S"
     gene            52906..54411
                     /gene="pyk"
                     /locus_tag="AC0DU4_000334"
     CDS             52906..54411
                     /gene="pyk"
                     /locus_tag="AC0DU4_000334"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0004743 - pyruvate kinase activity
                     [Evidence IEA];
                     GO_function: GO:0030955 - potassium ion binding [Evidence
                     IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HIN4236357.1"
                     /translation="MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAK
                     LIEAGANTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFEGE
                     AKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALGIYDDVEVGRQVLVDDGKLGLRV
                     VAKDDATREFEVEVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIA
                     ISFVRTAKDVNEVRAICEETGNGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMG
                     IEVPFEMVPVYQKMIIKKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGT
                     DATMLSGESANGKYPLESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVK
                     DATNSMDIKLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTD
                     APSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTVR"
     gene            complement(54685..54933)
                     /locus_tag="AC0DU4_000335"
     CDS             complement(54685..54933)
                     /locus_tag="AC0DU4_000335"
                     /inference="COORDINATES: protein motif:HMM:NF012798.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HIN4236358.1"
                     /translation="MQKANTKLEKPINQPLSSHIFRHTLLSTLAEKNAIMVRVEHKNA
                     KTVNNIYTHVSKRMEQATLEVLNTISLNRKYIRSNLDK"
     gene            complement(55265..55372)
                     /locus_tag="AC0DU4_000336"
                     /pseudo
     CDS             complement(55265..55372)
                     /locus_tag="AC0DU4_000336"
                     /inference="COORDINATES: protein motif:HMM:NF012920.6"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="S24 family peptidase"
     gene            56172..57044
                     /locus_tag="AC0DU4_000337"
     CDS             56172..57044
                     /locus_tag="AC0DU4_000337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4300 family protein"
                     /protein_id="HIN4236359.1"
                     /translation="MKKSRKLATLGICSALFLGLAACQQQHATSEGTNQRQSSSAKVP
                     WKASYTNLNNQVSTEEVKSLLSAHLDPNSVDTFFNLVNDYNTIVGSTGLSGDFTSFTH
                     TEYDVEKISHLWNQKKGDFVGTNCRINSYCLLKNSVTIPKLEKNDQLLFLDNDAIDKG
                     KVFDSQDKEEFDILFSRVPTESTTDVKVHAEKMEAFFSQFQFNEKARMLSVVLHDNLD
                     GEYLFVGHVGVLVPADDGFLFVEKLTFEEPYQAIKFASKEDCYKYLGTKYADYTGEGL
                     AKPFIMDNDKWVKL"
     gene            complement(57190..57305)
                     /locus_tag="AC0DU4_000338"
                     /pseudo
     CDS             complement(57190..57305)
                     /locus_tag="AC0DU4_000338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
BASE COUNT        17568 a        10140 c        12524 g        17073 t
ORIGIN      
        1 cacagaactg gcattttatt ttttaggatc ttgatgggtt aggttcaatc cccaagggac
       61 caaattttca gttttatttt tgatacgagc tatattgtcc ttatgacgaa tgataatcaa
      121 actagcaagt gctaagataa tagcgatgaa gagagagtca tagttactca ggataaaacc
      181 aaaaagtgga aagagcagaa ccccgataac agccgcgatc gatgctgtga cactagacag
      241 tgaaatcata ctgccaagat agagagctcc aaagaagata atcgcaaggt agagacagaa
      301 gataggcgca aatccgaaaa tcactccagc actggttgcg acagccttac cacctttaaa
      361 tcctgcaaag atagggaagg tatggccgat aacagccaaa agtccaaaga tgagaggaga
      421 aacgccttgt agatgaaaaa taatcggaag cagcgttgct agggttcctt tgaaaaagtc
      481 aatcacaaag gttgccatac cagctttctt acctaaaatg cggaaggtat tggtcgttcc
      541 agtgttacca gaaccatgct cgcgtagatt gatttgaaag aatacttgtc caatccagag
      601 accagatgga atcgaaccca gcagataggc taggattaat aaaattattg taatcatact
      661 cctattatat catgaattgg gaaagaaaag cagagaatct ctgctgaaat tgtcacatcg
      721 gagaaagaaa aattttgcaa aatccttgga aaacctgtag aatagtaaag atgaacgaat
      781 aggaggttcc ttgtgtcaaa aaaggaaatc aatattaaca attataatga tgatgctatt
      841 caggtgctag aagggttgga tgcggtccga aaacgtccag ggatgtatat tggatcgacc
      901 gatggcgctg gtcttcatca cctagtttgg gaaatcgttg ataatgcagt cgatgaagcc
      961 ttgtctgggt ttggtgatcg tattgatgta actatcaata aagacggtag tctaacggtt
     1021 caagaccatg gacgtgggat gccgacaggt atgcacgcta tgggaattcc aactgttgag
     1081 gttatcttta ccattcttca tgccggaggg aaattcggtc aaggtggcta taagacatca
     1141 ggtggacttc acggagtggg ttcttccgtt gttaacgccc tttctagctg gttagaagtt
     1201 gaaattaccc gtgatggcgc agtttacaag caacgttttg aaaatggtgg aaaacctgtc
     1261 acgactttga agaaagtcgg tacagcaccc aagtctaaaa caggcaccaa agttactttt
     1321 atgcctgacg cgactatctt ttctacgaca gatttcaagt acaataccat ttcagagcgc
     1381 cttaatgaat cagcctttct cttgaaaaat gtgaccttgt ctttaacgga caagcgaaca
     1441 gatgaagcga ttgagttcca ctatgagaat ggagtacaag attttgtttc ttatctcaac
     1501 gaagataagg aaatcttgac gccagttctt tactttgaag gggaagacaa tggttttcaa
     1561 gtggaagtag ccctccagta caatgacgga ttctcagata acattctatc ctttgtcaat
     1621 aacgttcgca ccaaggacgg tggaacgcac gagacaggac tcaagtctgc cattaccaag
     1681 gtcatgaatg actatgcacg taaaacaggt cttctcaagg aaaaagataa aaaccttgaa
     1741 ggttcagact atcgtgaggg actagcggcc gttctttcta tcttagttcc tgaagaacac
     1801 ttgcagtttg aaggacagac caaggataaa ctaggaagcc ccctagctcg cccagttgtg
     1861 gatggaatag tggctgataa gttgaccttt ttccttatgg aaaatgggga attagcttct
     1921 aacctcatcc gcaaggctat caaggcccgt gatgctcgtg aagcagcacg taaggcgcgt
     1981 gatgagagcc gaaatgggaa gaaaaacaag aaagataagg gcttgttgtc tgggaaattg
     2041 accccagccc aatctaagaa tcctgctaag aatgaactct atctagttga gggggactct
     2101 gccggtggtt ctgccaaaca aggtcgtgac cgcaagttcc aggctattct acctcttcgt
     2161 ggtaaggtta tcaatacagc caaggccaag atggcggata tcctcaaaaa tgaagagatc
     2221 aataccatga tttataccat tggtgcgggt gttggagcag acttttctat tgaagatgcc
     2281 aactatgata agatcattat catgaccgat gcggataccg acggtgccca tatccagacc
     2341 ttgctcttga catttttcta ccgttacatg cgtccgctag tcgaggcagg tcatgtctat
     2401 attgccctcc cacctcttta caagatgtcc aaaggtaaag gcaagaaaga agaagtggcc
     2461 tacgcttgga cggacggaga actagaagaa ctccgtaaac agttcggtaa aggcgctacc
     2521 ctccaacgat acaaaggact tggtgagatg aatgcggacc agctctggga aacaaccatg
     2581 aacccagaaa cacgtaccct catccgtgtc acaattgaag atttagcgcg cgccgaacgc
     2641 cgcgtcaatg ttctcatggg agataaggta gaaccacgcc gtaaatggat tgaagataat
     2701 gtcaagttta cgctagaaga agcgacagtg ttttaatgaa agaaaataat atgttagtaa
     2761 actggaaatt agagtcggat gtgaatgact atgtgaaaaa gcagtttgaa aatcttggtt
     2821 tgaaaaaatt gcaggattat taatgaagaa tctgctatga gtgcttatct taaagaggcg
     2881 cttaagggag cggttaagac acaaactaag actaattttg gaaaaccaga ttttcatatt
     2941 gaaaaataca aacaggatag tttggttact tatcgtaact gaacacggga cgaattcccg
     3001 taaaatatct tttactgcat aaaaacctac tctacattct ttgaaaggag ttgaacacgc
     3061 cctagatact gtgtgaaaaa gataaattct cttgtgagtt tgcttacttc aagaattttc
     3121 tattttcact tggtatttta tgggctttgt atcttatgtc taacattcaa aacatgtccc
     3181 tggaggacat catgggagag cgctttggtc gctactccaa gtacattatt caagaccggg
     3241 ctttgccaga tattcgtgat gggttgaagc cggttcaacg ccgtattctt tattctatga
     3301 ataaggatag caatactttt gacaagagct accgtaagtc ggccaagtca gtcgggaaca
     3361 tcatggggaa tttccaccca cacggggatt cttctatcta tgatgccatg gttcgtatgt
     3421 cacagaactg gaaaaatcgt gagattctag ttgaaatgca cggtaataac ggttctatgg
     3481 acggagatcc tcctgcggct atgcgttata ctgaggcacg tttgtctgaa attgcaggct
     3541 accttcttca ggatatcgag aaaaagacag ttccttttgc atggaacttt gacgatacgg
     3601 agaaagaacc aacggtcttg ccagcagcct ttccaaacct cttggtcaat ggttcgactg
     3661 ggatttcggc tggttatgcc acagacattc ctccccataa tttagctgag gtcatagatg
     3721 ctgcagttta catgattgac cacccaactg caaagattga taaactcatg gaattcttac
     3781 ctggaccaga cttccctaca ggggctatta ttcagggtcg tgatgaaatc aagaaagcct
     3841 atgagactgg gaaagggcgc gtggttgttc gttccaagac tgaaattgaa aagctaaaag
     3901 gtggtaagga acaaatcgtt attactgaga ttccttatga aatcaataag gccaatctag
     3961 tcaagaaaat cgatgatgtt cgtgttaata acaaggtagc tgggattgct gaggttcgtg
     4021 atgagtctga ccgtgatggt cttcgtatcg ctattgaact taagaaagac gctaatactg
     4081 agcttgttct caactactta tttaagtaca ccgacctaca aatcaactac aactttaata
     4141 tggtggcgat tgacaatttc acacctcgtc aggttgggat tgttccaatc ctgtctagct
     4201 acatcgctca ccgtcgagaa gtgattttgg cgcgttcacg ctttgacaaa gaaaaggctg
     4261 agaaacgtct ccgtatcgtc gaaggtttga ttcgtgtgat ttcgattttg gatgaagtca
     4321 ttgctcttat ccgtgcttct gagaataagg cggacgccaa ggaaaacctc aaagttagct
     4381 atgattttac ggaagaacag gctgaggcta tcgtaacttt gcaactgtac cgtttgacca
     4441 ataccgatgt ggttgtcttg caggaagaag aagcagagct tcgtgagaag attgctatgc
     4501 tggcggctat tatcggtgat gaaaggacta tgtacaatct catgaagaaa gaacttcgtg
     4561 aggtcaagaa gaactttgca actcctcgtt tgagttcttt agaagacact gcgaaagcaa
     4621 ttgagattga tacagctagt cttatcgctg aggaagatac ctacgtcagc gtgaccaagg
     4681 caggttacat caagcgtacc agtccacgtt cctttgcggc ttccaccttg gaagaaattg
     4741 gcaagcgtga tgatgaccgt ttgatttttg ttcaatctgc caagacaacc cagcacctct
     4801 tgatgttcac aagtcttgga aatgtcatct acagaccaat ccatgagttg gcagatattc
     4861 gttggaagga catcggagag catctgagcc aaaccatcac aaactttgaa acgaatgaag
     4921 caatccttta tgtggaagta ctggatcagt ttgacgatgc gacaacctac tttgcagcga
     4981 ctcgccttgg tcaaatcaaa cgggtagagc gaaaagaatt cactccatgg cggacctata
     5041 gatctaagtc tgtcaagtat gctaagctca aagacgatac agatcagatt gtagcagtgg
     5101 ctccgattaa actagatgat gttgtcttgg ttagtcaaaa tggttatgcc ctgcgtttca
     5161 atatcgaaga ggttccggtt gtcggtgcta aggcagcagg tgtcaaggct atgaatttga
     5221 aagaagatga tgtcctccaa tctggcttta tctgtaatac ttcgtccttc tacctcttga
     5281 cccagcgtgg aagcttgaaa cgtgtttcca ttgaggaaat tctagcaacc agccgtgcca
     5341 aacgaggatt acaagtcttg cgtgagttga aaaacaaacc gcatcgtgtc ttcttggcag
     5401 gagcagttgc agagcaagga tttgttggcg atttcttcag tacggaagtg gatgtgaacg
     5461 accaaactct gcttgtccaa tccaataaag gaacaatcta tgaaagccga ttgcaagact
     5521 tgaacttgtc agaacgcact agcaatggaa gcttcatttc tgacacgatt tcagatgaag
     5581 aagtttttga cgcttatctt caggaagtag ttactgaaga taaataagtg aaatgaagaa
     5641 tcagttctaa gatggttttt attggaggaa ttttctgaaa attacaaaat atacttgcta
     5701 ttttagaaaa atagtgtaga atataagaaa taggttttta gaataaggag tggaatatga
     5761 cagtaacgat tgattgggaa aacctcggtt tttcctatat gaaattacct tatcgctatc
     5821 ttgctcattt caaaaatgga caatgggatc aaggagagct tacagaggat gcaactttgc
     5881 atatttcaga gtcttctcca agtcttcact atggacaaca agcatttgaa ggtttgaaag
     5941 cttatcgtac taaggatggc agtgttcaac tgttccgtcc tgatgaaaat gctaaacgcc
     6001 tgcaacgtac atgtgaccgt ctcttgatgc cacaagttcc gacagacatg tttgtagaag
     6061 cttgtaaagc agttgtccgt gcgaatgaag aatacgtacc accatacgga ataggtggaa
     6121 ccttatatct tcgccctctt ttgattggtg tcggagatat tatcggggta aaaccggcag
     6181 aagagtacat tttcaccatc tttgctatgc cagttggaaa ttactttaaa ggtggtttgg
     6241 tcccaaccaa cttcttgatt caggatgagt acgaccgtgc agcaccaaat ggtacaggtg
     6301 cggctaaggt tggtggaaac tatgctgcaa gtctcttacc aggaaaaatg gccaagtcac
     6361 gccatttctc agatgttatc tatctggacc catcaactca tacaaagatt gaagaagtcg
     6421 gatcagctaa tttctttgga attacagctg ataatgaatt tgtaacacca ttgagtccat
     6481 ctatcttgcc atctattacc aagtattcct tgctttattt ggcagaacat cgcttgggat
     6541 taactcctat tgagggtgat gttccaattg ataatcttga ccgttttgta gaggcaggtg
     6601 cctgtggtac agcagcggtt atttctccaa ttggaggtat tcaacatggt gatgatttcc
     6661 atgtattcta tagtgaaaca gaagtaggtc ctgtgacgcg taaattatat aatgaattga
     6721 cgggtattca gtttggcgat attgaagcgc cagaaggttg gattgtaaaa gtagattaaa
     6781 ataaaccaaa ggagattttt tatgaaatag aaaaagtggc tcttaacagc aggagtggtc
     6841 ctgagcacgt tagctatttt agtggcttgt ggaaaaactg ataaagaagc agatgcaccg
     6901 acaacatttt cttatgtcta tgcagtagat ccagcatcat tgggctacag tataacgact
     6961 cgaacatcga cgacagacgt tattggaaat gttattgatg gtttgatgga aaatgataaa
     7021 tacggcaatg ttgctccttc tcaaaaagac tatgatttga atagtacagg atgggctcca
     7081 agctatcaag atccagcgtc ttacttgaat attatggatc caaaatctgg ttctgccatg
     7141 aaacaccttg gtattacgaa aggaaaagat aaggatgttg tagctaaacc tggtttggat
     7201 aaatataaga aattgttaga agatgctgtt tctgagacca ctgacctaga gaagagatat
     7261 gaaaaatatg ccaaagctca agcttggtcg acagatagtt cattattgat gccaacagct
     7321 tcatctggtg gttctccaat tgtaagtaac gtagtaccat tctcaaaacc atactcacaa
     7381 gttggtatta agggggaacc atatatcttt aaaggaatga aattgcaaaa agatattgtt
     7441 acaacaaaag aatataacga ggtttttaaa aaatggcaaa aagaaaaatt ggaatccaat
     7501 agcaaatacc aaaaagaact agaaaaacac attaaataag gaatggtatt gatcttgata
     7561 aaatttttaa aatactgtca ttttgaatat aaaggagttt gatatggagt ggattagatt
     7621 aataggaata gcaatcattg ttgtgggttt tattttaaaa tttgatacaa ttgcaacagt
     7681 agtcttagct ggtttggtta cagctttagt ttcaggtgtt tctctcgttg aatttttgga
     7741 gattttggga aaagaattta gcaatcagcg agtgctcacg atttttatgg ttaccttgcc
     7801 tcttgtgggg ctgtcagaaa cctttggact caagcaacga tcaatcgatt tgattcgaaa
     7861 gattaaaggt ctgacagttg gaaacttcta tacagtttat ttctttattc gagagttagc
     7921 tggtttcttt tcaattcgtc taggaggaca ccctcagttt gtcagacctt tggttcaacc
     7981 tatgggagaa gcagctgcag agtctcaatt aggtagaaag ttaacagagg ttgaagatga
     8041 gacaataaaa gcgcgtgcgg ctgcgaatga aaattttgga aatttctttg ctcaaaatac
     8101 gtttgtaggt gctgggggag tcctcttgat agggggaaca ttagatcagt taggctatga
     8161 aagcaattat gcagggattg cttctacatc tattattgtt gctgttataa cacttattgt
     8221 agtggggatt tacaattatt tatttgataa aaaattgata tcaaaaaaga ctaggggagg
     8281 agaacaaaaa tgacagagtt ggcaaagcaa ctattagagt tgacctatat tgtgattggt
     8341 tgtcaatttc tccatacagc ctattgtagt tataaagata aaacaaaccc agttcgactt
     8401 gggacatctg cattttggac tctattgtct attacgttta taggtggttc ctatatgcca
     8461 aatatgagta ttggtattat tgtaatccta ttatcgctgt taacattgtt taagcaagtc
     8521 cgtatcggaa ccttgccatc cttagatgaa atgaaagcca atattgaatc taacaggttg
     8581 aaaaataaaa tttttattcc agttatgctg atggcaatac ttgcgttggt cttagcgcaa
     8641 atgattccag aatttagcaa gatttcgatt agccttgccg ccttgtttgc tacaatttct
     8701 gttcttgtga ttaccaatag tcaccctaag agtctgttat cagaaaataa tcgaatgact
     8761 cagcaagttt caacaagtgg gattgttcct caattattag gggctttggg ggctattttt
     8821 actgtagcag gtgttggtga tgttatctct catctgatta gcggtattgt tccttcagat
     8881 agtcgcttta taggagtttt ggcctatgtt cttggaatgg ttctattcac aatgattatg
     8941 ggaaatgctt ttgcagcatt caccgttatt acagcaggtg ttggagttcc cttcgtattt
     9001 gctctgggag ctaatccaat tgtggctggt gctcttgcca tgacagcagg ttattgtggg
     9061 accttattga ccccaatggc tgctaatttt aacgctctac cagcagcatt gatggatatg
     9121 aaagatcaga atggcgttat aaaggctcaa gcaggtgttg ctctagtaat gattgttatt
     9181 cacatattct taatgtactt tctcgcattt tagtaaagga aaataaaatg aaaatattgg
     9241 ttacaggttt taatcctttt ggaggtgaaa agattaatcc agctttggag gctgtaaaat
     9301 tattaccatc tgagattaat ggggctgaag ttcgctgggt agaaattcca acggtttttt
     9361 ataagtcgtc agaagtttta gaggcagaaa tattacgata tcaaccagat gctgtacttt
     9421 gtattggaca agcaggcggc aggaccggct taacacctga acgagtggct attaatcaag
     9481 atgatgctcg catacctgat aacgaaggca atcaaccaat tgatacaccg attcgtattg
     9541 atggagcatc ggcctatttt agtagtttac ctatcaaagc gatggtacaa gctatcaaaa
     9601 aacagggact tccggcagtt gtatccaata gtgcaggaac ctttgtttgc aatcatttga
     9661 tgtaccaagc tctttattta gtggataaaa aattccctaa tatgagagca ggtttcatgc
     9721 atattccata tatgatggaa caagtagtaa ataagccgaa tactgcagga atgagtctat
     9781 gtgatattgt aagaggcata gaggtagcta ttgaagctat tgtagactac aaagataagg
     9841 atttgcagtt agtaggcggt gagactcact gataacctaa aaaggatagt caattatgct
     9901 tgtttactaa ctattaacta tgctaaatcg attgaggttg tttacataaa actctatatc
     9961 agagaagcct gatatagagt tttttcttgc tagttttagg attttcttgt aaaatagaaa
    10021 aagtgaagag aggtatgaaa tgagcaagaa agataaaaaa atcgaaattc aagtagcgga
    10081 tgccaaagtt aatgttggta aagacagttt tgaaggttat acattgacta tcggtaaaaa
    10141 agttatcgga gaaattgccg aattagacgg acaatttgcc attataaaga atgggaatgt
    10201 cgatagtttt tataaaaaat tggaaaaagc tgtggaaatt ttgattgaaa attataattt
    10261 agcaaaataa gtcttgtttt tttgaaattt tcatgatata atagtccatg ttgattgtag
    10321 gagagatagc gaagaggcta aacgcggcgg actgtaaatc cgctccttcg ggttcggggg
    10381 ttcgaatccc tctctctcca tttcattaat ggggtatagc caagcggtaa ggcaagggac
    10441 tttgactccc tcatgcgttg gttcgaatcc agctacccca gttcttaggt aataatcaag
    10501 ataaaaagca aaatatctta gggtatttta tttttataat tgaaagacgt gaatgatatg
    10561 aacatgtcct tgcgggtgct taggaaaaaa attataagta tgtcaagttt aagaaaaact
    10621 tgattgttgg aggatttttt agatgaatga atttgaagat ttgctaaata gcgttagtca
    10681 agttgagact ggtgatgttg ttagtgctga agtattgaca gttgatgcga ctcaagctaa
    10741 cgttgcaatc tctggaactg gtgttgaagg tgtcttgact cttcgcgaat tgacaaacga
    10801 tcgtgatgca gatatcaatg actttgttaa agtaggagaa gtattggatg ttcttgtact
    10861 tcgtcaagta gttggtaaag atactgatac agttacatac cttgtatcta aaaaacgcct
    10921 tgaagctcgc aaagcatggg acaaacttgt tggtcgcgaa gaagaagttg ttactgttaa
    10981 aggaacgcgt gccgttaaag gtggactttc agtagaattt gaaggtgttc gtggatttat
    11041 cccagcttca atgttggata ctcgtttcgt acgtaacgct gagcgttttg taggtcaaga
    11101 atttgatact aaaatcaaag aagttaacgc taaagaaaac cgcttcatcc tttcacgtcg
    11161 tgaagttgtt gaagcagcta ctgcagcagc tcgcgctgaa gtattcggta aattggctgt
    11221 tggtgatgtt gtaactggta aagttgctcg tatcacaagc ttcggcgctt tcgtcgatct
    11281 tggtggtgtt gacggattgg ttcacttgac tgaattgtca catgaacgta atgtatcacc
    11341 aaaatcagtt gtaactgttg gtgaagaaat tgaagtgaaa atccttgatc ttaacgaaga
    11401 agaaggacgt gtatcacttt cacttaaagc aacagtacca ggaccatggg atggcgttga
    11461 gcaaaaattg gctaaaggtg atgtagtaga aggaacagtt aaacgtttga ctgacttcgg
    11521 tgcatttgtt gaagtattgc caggtatcga tggacttgtt cacgtatcac aaatttcaca
    11581 caaacggatt gaaaacccaa aagaagctct taaagttggt caagaagttc aagttaaagt
    11641 tcttgaagtt aacgcagatg cagaacgcgt gtcactttct attaaagctc ttgaagaacg
    11701 tccagcccaa gaagaaggac aaaaagaaga aaaacgtgtt gctcgtccac gtcgtccaag
    11761 acgtcaagaa aagcgtgatt tcgaacttcc agaaacacaa acaggatttt caatggctga
    11821 tttgtttggt gatatcgaac tttaatcaaa ttgaaaattc acaaaatcct ttgtttacta
    11881 aacaaaggat ttttctggct ctttgtcaac tgtagtgggt tgaaaaaaag ctaagctcga
    11941 gaaaggacaa atttcgtcct ttcttttttg atattcagag cgatgaaaat ccgttttttg
    12001 aagttttcaa agttccgaaa accaaaggca ttgcgcttga taagtttgat gagattattg
    12061 gtcgcttcca gtttggcatt agaatagtgt agttgaaggg cgttgacaat cttttcttta
    12121 tctttgagga aggttttaaa gacagtctga aaaataggat gaacctgctt tagattgtcc
    12181 tcaatgagtc cgaaaaattt ctccggtttc ttattctgaa agtgaaacag caagagttga
    12241 tagagctgat agtggtgttt caagtcttct gaatagctca aaagcttgtc taaaatctgg
    12301 atattagggt ctttaatgtc tagtaatttt gtgataaaat gtaattgttc catatgaatc
    12361 tttctaatga gttgtttggt cgcttttcat tatagatctt atgggacttt ttttctacaa
    12421 taaaataggc tccataatat ctataggggg gttacccact acaaatatta tagagcccaa
    12481 aatcctttgt ttactaaaca agggattttt cttttgtctc tgctcctttt ttgatataat
    12541 agttctatgt taaaatcaga aaaacaatca cgttatcaaa tgttaaatga agaattgtcc
    12601 ttcctattgg aaggcgaaac caatgttttg gctaatcttt ccaacgccag tgctctcata
    12661 aaatcacgtt ttcctaatac cgtatttgca ggcttttatt tgttcgatgg aaaggaattg
    12721 gttttaggcc ccttccaagg aggtgtttcc tgcatccgta ttgcactagg caagggtgtt
    12781 tgtggtgagg cagctcactt tcaggaaact gttattgttg gagatgtgac gacctatctc
    12841 aactatattt cttgtgatag tctagctaaa agtgaaattg tggtgccgat gatgaagaat
    12901 ggtcagttac ttggagttct ggatctggat tcttcagaga ttgaggatta cgatgctatg
    12961 gatcgagatt atttggaaca atttgtcgct attttgcttg aaaagacaac atgggacttt
    13021 acgatgtttg aggaaaaatc ttaatgtatc aagcacttta tcgaaaatat agaagtcaaa
    13081 acttctccca gttagttggt caagaagttg tggctaagac tcttaaacaa gcggtggagc
    13141 aagagaaaat aagtcacgct tatctttttt ctggtcctcg tggaacggga aaaaccagtg
    13201 ttgctaaaat ctttgccaag gctatgaact gtcccaatca agtgggtggc gaaccttgca
    13261 ataactgcta tatttgtcaa gcagtgacgg acggtagttt agaagatgtc attgaaatgg
    13321 atgcagcttc taataatggg gtagatgaaa ttcgcgaaat tcgtgataaa tctacctatg
    13381 cgcctagcct tgctcgttat aaggtttata tcatagatga ggttcacatg ctgtctacag
    13441 gggcttttaa tgccctccta aagacgctgg aagaaccaac acagaatgta gtctttattt
    13501 tggccactac tgaattgcac aagattcctg ctactattct atcccgtgtg caacgttttg
    13561 agtttaaatc aattaagaca caggatatta aggaacatat tcactatatc ttagaaaaag
    13621 aaaatatcag ttctgaacca gaggctgtgg aaatcattgc cagacgggcg gaaggtggaa
    13681 tgcgggacgc cttgtctatt ttggatcaag ccctgagttt gacacaggga aatgagctga
    13741 cgactgctat ctctgaagaa attactggca ccattagcct atcagccttg gatgattatg
    13801 tggcggcctt gtctcaacag gatgttccca aagctttgtc ttgcttgaat cttctttttg
    13861 acaatggtaa gagcatgact cgttttgtga ccgatctttt gcactattta agagacttgt
    13921 taattgttca aacaggggga gaaaatactc atcatagttc agtctttgta gaaaatttgg
    13981 cacttcctca aaaaaatctg tttgaaatga ttcgcttagc aacagtgagt ttagcagata
    14041 ttaagtctag tttgcagccc aagatttatg ctgaaatgat gaccgtccgt ttggcggaaa
    14101 tcaagcccga accagctcta tcaggagcgg ttgaaaatga aattgctacg ctgagacagg
    14161 aagttgcccg tctcaaacaa gagctttcta atgtaggtgc ggttcctaaa caagttgcac
    14221 cagctcctag tcgaccagct acgggcaaaa cagtctatcg tgtcgatcgc aataaagtgc
    14281 aatctatctt acaagaggcc gtcgaaaatc ctgatttagc acgtcaaaat ctaattcgtt
    14341 tgcagaatgc ctggggagag gtaattgaaa gtctaggtgg gccggacaag gctctgctag
    14401 ttggttctca accggttgct gccaatgaac accatgctat tcttgctttt gagtctaact
    14461 tcaatgctgg tcaaactatg aaacgagaca atctcaatac catgtttggt aatatcctca
    14521 gtcaggcggc aggtttttca cctgagattt tagctatttc catggaggaa tggaaagaag
    14581 ttcgcgcagc cttttcagcc aaagccaaat cttctcaaac tgaaaaagaa gtagaagaaa
    14641 gcctgattcc agaaggattt gaatttttgg ctgataaagt gaaggtagag gaagactaaa
    14701 gaaagatttc atgatacaat aagtttatga ataaacaaca atttattatt atggcgctgt
    14761 ttacagctgc tgagacctat tttttcaatg aagcctggat gactggccgc tatattatgg
    14821 cagccttttg ggcaatttta ctctttagaa atttccgagt cagttatgtg atgggcaaaa
    14881 tcgttgatgt catcgatcag cattttaata ggaaagacta gccctcagct tccagacaaa
    14941 atcaaagcct tttaggcttt tttttgttat actagaaaag tatatttata gaatttttgc
    15001 tctatttctg gggaaatcag acgtttttct agtaagtact gtaaaagttt tgaaaaagaa
    15061 aggaactatc atgtcagtat tagagattaa agatcttcac gttgagattg aaggaaaaga
    15121 aattttaaaa ggggttaacc tgaccctgaa aacaggagaa attgccgcta tcatgggacc
    15181 aaatggtaca ggtaaatcga ctctttctgc cgctatcatg ggaaatccaa actatgaagt
    15241 aactaaaggt gaagttttgt ttgatggcgt aaacatcctt gagttggaag tggatgagcg
    15301 tgcgcgtatg ggacttttcc ttgctatgca atacccatca gaaatccctg gaattaccaa
    15361 tgctgagttt cttcgtgccg ctatgaatgc gggtaaagaa gatgatgaga agatttcagt
    15421 tcgtgagttt attactaagc tagatgaaaa aatggaattg ctcaacatga aagaagaaat
    15481 ggcagagcgt tacctcaacg aaggcttctc tggtggtgag aaaaaacgca atgaaattct
    15541 tcaacttttg atgttggagc caacatttgc tcttttggac gagattgact caggtcttga
    15601 tattgacgct cttaaagttg tgtctaaagg tgtcaatgcc atgcgtggtg aaggttttgg
    15661 tgctatgatc atcactcact accaacgtct tttgaactat atcacacctg atgtggtaca
    15721 cgtgatgatg gaaggtcgtg ttgtcctttc tggtggtcca gaattggctg cgcgtttgga
    15781 acgtgaagga tacgcaaaat tagctgaaga acttggctac gactacaagg aagaattgta
    15841 atttcctcgt atcttttagg agaagtaaat gactagagaa aatattaaac ttttttcaga
    15901 aatgcacgct gaaccaagct ggttggctga tctccgtcaa aaagcttttg acaagattga
    15961 gactttggaa ttaccagtta ttgagcgtgt caaattccac cgttggaatc tgggtgatgg
    16021 aacgattaca gaaaatgagc catcagcaaa tgttccagat ttcacagctt tagatcatca
    16081 cttgaagttg gtgcaagtag gaactcaaac tgttttcgaa caaactccag ttgagttagc
    16141 tgaacagggt gttgtcttca cagactttca ctcagcttta gaagaaattc cagagctgat
    16201 cgaagaattc ttcatgtcat ctgttaagta tgatgatgac aagttggcgg cttaccacac
    16261 agcttacttt aacagtggtg ctgtactcta tattccagat aacgtagaaa tcacagagcc
    16321 aattgaagga attttctacc aagatagcga tagcaatgtg ccgtttaaca agcatattat
    16381 gattatcgct ggtaaaaatt ctaagattag ttatctggag cgtttagagt cacgcggtga
    16441 aggaagtgac aaagtaactg ccaatatcac agtggaagtg attgcacgtt ctggtgcgca
    16501 agtcaagttt gctgctatcg accgtctagg tgaaaacgtc actgcctaca ttagccgtcg
    16561 tggtaaatta ggcaacgatg caagtattga ctgggctatc ggtgtcatga acgaaggaaa
    16621 tgtcgttgct gattttgata gtgacttgat tggtaatggt agccatgctg acctcaaggt
    16681 tgtagctctt tcaagtggtc gtcaggtaca agggattgat actcgtgtaa ctaactatgg
    16741 ctgcaactct atcggaaata tcctacaaca tggggttatc cttgaaaaag caactttgac
    16801 tttcaatggt atcggccaca tcatcaaggg tgctaaggga gcagatgcgc aacaagagag
    16861 ccgtgttctc atgctttcag accaagcgcg ttcagatgct aacccaattc ttttgattga
    16921 tgaaaatgat gtcactgcag gacacgcagc gtctatcgga caagttgatc cagaagacat
    16981 gtattacctc atgagtcgtg gattggataa ggcaactgca gagcgtttgg ttgttcgtgg
    17041 tttccttgga tctgttatcg tggagattcc agtcaaggaa gttcgtgatg aaatgattgc
    17101 aactatcgaa gagaaattgt caaaacgcta aggggaagcc tatgttagat gtagaagcga
    17161 ttcgcaagga ttttccaatt ttagatcaga ttgtcaatga tgaacctctg gtctatctgg
    17221 acaatgctgc gacgacacaa aaacccctag tagttctgaa agctattaac agttactatg
    17281 agcaggacaa tgccaatgtt caccgtggtg tccatacctt agcggaacga gcgacagctt
    17341 cttatgaagc tgctcgtgaa accattcgta agtttattaa tgcaggctct acaaaggaag
    17401 ttctctttac cagaggaacg acaaccagcc ttaactgggt ggcacgcttt gctgaggaaa
    17461 ttctcactga gggagaccag gtcttgattt cagtaatgga acaccattct aatatcattc
    17521 catggcagga agcttgtcga aagactggag cagagcttgt ctatgtctat cttaaagacg
    17581 gtgccttgga tatggaggat ttgcgagcta aattgactga taaggttaaa tttgtttccc
    17641 tagctcatgc ctccaatgtt cttggtgtga tcaatccgat caaggaaatc actcaattag
    17701 cccaccaagt tggggcaatc atggtagtgg atggtgctca atctacacct catatgaaga
    17761 ttgatgtcca ggacttggat ctggactttt tcgccttttc gggtcacaag atggctggtc
    17821 cgactggtat cggtgtcctt tacggcaaag aaaagtatct tgagcaaatg tctccagtag
    17881 aatttggcgg cgagatgatt gattttgtct acgagcaatt tgctagttgg aaggaattgc
    17941 cttggaaatt tgaggctgga acgccaaata tggcaggagc tattggactt gcgactgcag
    18001 ttgattattt ggaaaagatt ggtatggatg ccgttgaagc tcatgaacag gaattgattg
    18061 cgtacgtcta tccaaaactg caggcaattg agggattgac catttacggt tctcaggatt
    18121 tggctcaacg ttcgggtgtt attgccttta acctaggtga tctccatcct cacgatcttg
    18181 cgacggctct ggattatgaa ggagtggctg ttcgtgctgg tcaccattgt gcgcaaccct
    18241 tgcttcagta tttggaagtc ccagcaacag ctcgtgcaag tttttatatc tacaatacca
    18301 aggcagattg cgacaaacta gtcgatgccc tacaaaagac aaaggagttt ttcaatggca
    18361 ctttctaaac tagatagcct ttatatggca gtggtagcag accattcgaa aaatccacat
    18421 caccaaggga agttagaaga tgctgagcaa atcagtctca acaatccgac ttgtggggat
    18481 gtcatcaacc tctctgtcaa gtttgatgca gaggaccgtt tggaagatat tgcttttcta
    18541 aattcaggat gcacgatttc aactgcttct gctagtatga tgacagatgc cgttttagga
    18601 aaaaccaaac aagaaatttt agaactggcg actatttttt ctgaaatggt tcaagggcaa
    18661 aaagatgagc gtcaaggcca acttggagac gcggcattct tgtcaggtgt tgccaaattc
    18721 cctcaaagaa tcaagtgtgc aaccctagct tggaatgccc ttaagaaaac aattgaaaat
    18781 caagaaaaac agtaagacaa gtttcttttg tcttatgaat tattagaaat gaagaaagaa
    18841 aggatactat ggctgaagaa agagtagaac caaaaccaat tgaccttggt gaatataaat
    18901 ttggtttcca tgacgatgta gagcctgtct tatcgacagg aaaaggactc aacgaaggtg
    18961 ttattcgtga attatctgct gctaagggtg agcctgagtg gatgttggag ttccgtttga
    19021 agtcttatga aaccttcaaa aaaatgccca tgcaaacttg gggagcagac ttgtcagaga
    19081 ttgactttga tgacttaatc tactaccaaa aaccatctga caaaccagcc cgttcttggg
    19141 atgatgtacc tgaaaagatt aaagaaacct ttgaacgtat cgggattcca gaagctgaac
    19201 gtgcttattt agcaggggct tctgcccagt acgagtcaga agtggtttac cacaacatga
    19261 aggaagagtt ccaaaaatta ggtattatct ttacagatac agattccgca ctcaaggaat
    19321 acccagactt atttaaacaa tactttgcga agttggtacc gccgacagat aacaagttgg
    19381 cagccctcaa ctcagcagta tggtcgggtg gaacttttat ctacgtgcca aaaggtgtca
    19441 aggtagatat tccacttcaa acttatttcc gtatcaataa cgaaaatata ggtcagttcg
    19501 aacgtacctt gattatcgtt gatgagggag caagcgtcca ctacgtagaa ggatgtacag
    19561 caccaacata ttcaagcaat agcttacacg ctgccattgt agaaattttt gctttggacg
    19621 gagcttatat gcgttataca actatccaaa actggtctga taacgtctat aacttggtaa
    19681 caaagcgtgc taaggctcaa aaggatgcca ctgttgagtg gattgatgga aacttgggtg
    19741 ccaaaacgac tatgaaatat ccatctgttt accttgatgg agaaggagcg cgtggtacca
    19801 tgctctctat cgcctttgct aatgcagggc aacaccaaga cacgggtgct aagatgattc
    19861 acaatgctcc acataccagc tcgtctattg tgtctaaatc catcgctaaa ggtggaggaa
    19921 aggttgacta ccgtggacaa gtcaccttta acaagaactc taagaaatct gtttcccaca
    19981 ttgaatgtga taccattatc atggatgact tgtcagcatc agatactatt ccatttaatg
    20041 aaattcacaa ctcgcaagtg gctttggaac acgaagccaa agtatctaag atttcagaag
    20101 agcaattgta ttatctcatg agccgtggat tgtcagaatc tgaggcaact gaaatgattg
    20161 tcatgggatt tgtagaaccc tttacaaaag aacttccaat ggaatacgca gttgagctga
    20221 accgcttgat tagctatgaa atggagggat cagttggata aaatttgatt ttatactctt
    20281 cgaaaatctc ttcaaaccac gtcagcatcg ccttaccgta tgtatggtta ctgacttcgt
    20341 cagtttcatc tacaacctca aaacagtgtt ttgagcaagc tgcggctagc ttcctagttt
    20401 gttctttgat tttgagtatt agatttactc aaaatcaagg attttgaaga tgaacttgta
    20461 tcaaaaaatc gcggtttaaa atcgcgattt tttataattt ctcgttaaca aagcggacaa
    20521 actgattcca ccaaactttt aagaagaagg ctttttcaat tttcttgtct gctaccattt
    20581 cgaaactagg gcgctctgtg gtgatgtaac cttgaccaat caagtccttg tcttcataag
    20641 tcaaatggcc aaccactgtt ccagcttcaa gtggtgctgg gattgctttg gaatcaggtg
    20701 tgaattgaac agattgggaa gattgattcc caacacgttc gattagatag atatcctctg
    20761 gagccactgc agttactgta tcttcttttc catcttgtac aggggttttg ctatcttgat
    20821 aggcatcgcc ttgttgaacg attttgcgaa gtgtaaatgt agaagaaata taatccatta
    20881 gggaagatgt agctgtaaat cgagcgtaag gattattgtc ttgatgatct gcatttaaaa
    20941 caactgtgat gactctcatg cctttttcga cagtagtacc aacaaaagac tctccagcct
    21001 tatctgttgt tcctgttttt agcccatcaa aaccaccacg gtaagcaggc ataccttcta
    21061 acatgtagtt ggttgaagtg attgtcatcc cagcaaaagt agaagaaggt tttttggtga
    21121 tttctaagac ttgtgggtat tttttgatga ggttgcgagc aacgatagcg acatcataag
    21181 cactaagctt attttcctca tcttttttag aacctgggta aatgttatcc cctagagttt
    21241 cattgttaag acctgtcgta ttgacaacag tggcatcctg aattccccat tccaagagtt
    21301 ttgcccgcat catatcgacg aaatcttttt ctgagccagc aattttctca gctagggcaa
    21361 tagcggcgct gttggcacta gataccagag ttgcttcaag caactcttcg acagtataat
    21421 tacgggcctc cataggaata ttactggctt cagaatttgt cgtcaattga taaggataat
    21481 cagaaatatc tacaggagtg gagagggtaa tacttccgtt ttccaaagct tcatagacca
    21541 gataaacagt aatcaatttt gttatggaag caatttcgac aggttgcgtt gcatccttct
    21601 catagagaat tttaccagta tttgcctcaa cagcaatcgc atgtttagcg gcaatggtaa
    21661 aatcttgagc aacagcagta gaagcacccc ctaaaagaga gacagttaac aaagttaaaa
    21721 atattttttt catagtagtc ttattctatc ataaagaaaa aaaatattct tgctttaata
    21781 attcatctgt taagcttttt gaaaatatgg taaaataaag tgagggaggt aactcatgtt
    21841 tcgtagaaat aaattatttt tttggaccac agaaatttta ctcttaacca tcatctttta
    21901 cctatggaga cagatgggat ctttgattaa cccttttgtt agcgtgctta atacaattat
    21961 gattccattt ttattagggg gctttcttta ttatttgaca aaccctattg ttactttctt
    22021 aaataaagtc tgtaaactca atcgtttgct tggtatttta attaccttgt gtactttggt
    22081 ctggggaatg gtcataggtg ttgtctatct cttacctatt ttgattaatc agttatctag
    22141 tttgattata tctagtcaaa ctatttatag tcgagtacaa gacttaatca tagacttatc
    22201 taattatcct gcgctccaga atttggatgt agaagctaca attcagcagt taaacttatc
    22261 ctatgttgat attcttcaaa atatcctaaa tagcgtatca aatagtgtgg ggagcgtctt
    22321 gtcagctctt atcagtactg ttttgatttt gattatgact ccagtttttt tggtttattt
    22381 cttattagat ggacataaat tcttgcccat gcttgaaaga acgattctaa agagggatcg
    22441 cttgcatatt gcaggcttat taaagaattt aaatgcgacg attgctcgct atattagtgg
    22501 agtttcgatt gacgcaatca ttataggttg tttggcttat attggctata gtattattgg
    22561 tttaaaatat gctttagttt ttgccatttt ttctggtgta gccaatttaa ttccttatgt
    22621 ggggccaagt attggtttga ttcctatgat catcgcaaat atattcactg atccccatag
    22681 actgctgatt gcagtgattt atatgcttgt tgttcagcag gtagatggca atatcttata
    22741 tcctcgaatc gtaggaagtg ttatgaaggt tcatccaatc acgattttag ttttactttt
    22801 gttgtcaagc aatatctatg gtgtagttgg aatgattgtc gcagtgccaa cctattctat
    22861 cttgaaagaa atttctaagt tcttatcccg tttgtatgaa aatcataaaa taatgaaaga
    22921 acgagaaaga gaattagcta agtaaaagtc aggagaaccc tgatttttct ttactggaag
    22981 tggcctttag attagaagac tgaaaataag ttaaagtctt aaactaattt tcacagctaa
    23041 gaatagtaga agttaatctg ataaaaatcg aaaaaaccag tggaattctg tgtcagggta
    23101 agttccactg gttttcatag tctattaaag ttcgaatgaa acctatttat agtagattga
    23161 aactagaata gtacacctct aattctaaaa cattgttaga aatcgatttg actgtcctga
    23221 tctattcgtc ctattcttat ttcattttac tatattttgg tgcaataagt gaaaagtaga
    23281 ccgaataata taaggattga ttttatagtt tttaaactca aatgaattga aataaagaga
    23341 gtacgaaaat tctcatctga aagtatttta gaataattct cttcgtgaat ttcttcaaaa
    23401 cagatagctt catcttaggt atgtgatttc tttttgcatt tttgagttag ataaggtata
    23461 atggttttat tgtcttttgg ggtcgttacg gattcgacag gcattatgag gcatattttg
    23521 cgactcgtgt ggcgacgtaa acgctcagtt aaatataact gcaaaaaata acacttctta
    23581 cgctctagct gcctaaaaac cagcaggcgt gacccgattt ggattgctcg tgttcaatga
    23641 caggtcttat tattagcgag atacgattaa gccttgtcta gcggtttgat aagagattga
    23701 tagactcgca gtttctagac ttgagttatg tgtcgagggg ctgttaaaat aatacataac
    23761 ctatggttgt agacaaatat gttggcaggt gtttggacgt gggttcgact cccaccggct
    23821 ccattattcc tttgcattcc ttggtaaaac gttgttaaat caacgttttt tatttttatc
    23881 tttggtattc ctttgcattc ttttgctaaa aagggagtca caaacagacc ctattttaaa
    23941 aaaaggatag aaaaaaggat acaacatttg tcgcatccta aaaataatct tttttcgacg
    24001 gaagacatgg gattcgaacc cacgcacgct attacacgcc taccgcgttt ccaacacggc
    24061 ctcttaagcc tcttgagtaa tcttccaata cttactcaaa tagtctacca taaaggctct
    24121 tatcttgcaa taaaaattct agaaataaga aaaaatgata gattttgaaa gaaaatgata
    24181 aaaaatgctt gacttcgaaa gaaagtatga tagaatgaat agtgtaaacg ataacaggag
    24241 gtgattcagt gttaaaaaca gaacgtaaac aactaatttt agaggagtta aatcagcatc
    24301 atgtagtttc tctagaaaaa ttagttagtt tgctagaaac gtcagaatca acggttcgaa
    24361 gagacttgga tgagttggaa gcggaaaaca agcttcgtcg tgtgcatggt ggagcagaac
    24421 tcccccactc cttacaggaa gaagaaacca ttcaagaaaa atctgtcaaa aaccttcaag
    24481 aaaagaagtt gctggctcag aaagcagcct ctctcattaa agaaaaagat gtcatcttta
    24541 tcgatgctgg aacaacaact gcttttttga ttcatgaatt ggtcaataag aatgttacag
    24601 ttgtgaccaa ctccattcac catgccgctc agttggttga aaagcagatt ccaactgtca
    24661 tggttggagg aaacgtcaag acggcgacag atgctagtat cgggggcgtt gctcttaacc
    24721 agattaacca attgcacttt gaccgtgcct ttatcggaat gaatggtgtt gacgatggct
    24781 attatacgac tcctgatatg gaggagggag ctgtgaaaag agctattttg gagaatgcca
    24841 agcagaccta cgtcttggtg gattcgtcaa aaattggaca aacttgcttt gccaaggtag
    24901 caccactcaa acgcgctatc gttatcacta gtcaagggca tgagctcttg caggttatta
    24961 aggagaaaac ggaggtaata gaagtatgat ttatacagtc acactcaatc catccattga
    25021 ctatatcgtt cgtttggacc aagtcaaagt tggtagtgtc aatcgtatgg acagtgatga
    25081 taagtttgct ggtgggaaag gaatcaatgt cagccgtgtc ttgaaacgtt tgaatatacc
    25141 aaatacagcg acgggattta tcggtggctt tactggtaaa tttatcacag atactctagc
    25201 agaggaagaa atcgagacac gttttgtcca agtggcagaa gatactcgta tcaatgttaa
    25261 aatcaaagca gaccaagaaa cagaaatcaa cggaacgggt ccaactgttg aaccggttca
    25321 gctagaagaa ttgaaagcta ttttatctag tctgacagta gaagatacag ttgtctttgc
    25381 aggttcaagt gctaaaaatc taggcaatgt tatctataag gatttgattt ccttgacgcg
    25441 ccagactggt gcgcaagtgg tctgtgactt tgaaggacag accttaattg atagtttgga
    25501 ctaccagcct cttcttgtaa aaccaaacaa tcatgaactt ggagcgattt ttggggttaa
    25561 actcgaaagt ttagatgaaa ttgagaaata cgctcgtgag ttactggcta agggtgctca
    25621 aaatgttatt atctctatgg ctggtgatgg cgcccttctt gtcacatctg agggagctta
    25681 cttcgctaaa ccaatcaaag gaacagtcaa aaattcagtt ggagctggtg attctatggt
    25741 tgctggattc acaggtgaat ttgtcaaatc aaaagacgca gtagaagcct tcaaatgggg
    25801 agtggcttgc ggaacggcaa ctaccttctc agatgacttg gcaacggcgg aatttattaa
    25861 agaaacatat ggaaaagttg aggtagaaaa aagatgaaaa ttcaagacct attgagaaaa
    25921 gatgtcatgt tgctagattt gcaggcaact gaaaaaacag ctgtcatcga cgagatgatt
    25981 aaaaatttga cagagcacgg ttatgtaaca gattttgaaa catttaaaga aggaattttg
    26041 gcgcgtgaag ctttgacttc tactggtttg ggtgatggaa tcgcaatgcc tcacagcaaa
    26101 aacgctgctg tcaaagaagc gacagttcta tttgctaagt caaacaaggg tgttgactac
    26161 gagagcttgg atggacaagc aactgacctc ttcttcatga ttgcagctcc agaaggtgcc
    26221 aatgatactc acttggcagc cttggcagaa ttgtctcaat acttgatgaa agacggtttt
    26281 gcagacaaac ttcgtcaagc aacatctgca ggccaagtta tcgaactttt tgaccaagct
    26341 tcagaaaaaa ctgaggaact tgttcaagca cctgctaatg actctggtga ctttatcgta
    26401 gctgttacag cttgtacaac aggtattgcc cacacttaca tggcccaaga agcccttcaa
    26461 aaagtagctg ctgaaatggg ggttggtatc aaggtcgaaa ccaacggtgc tagcggtgtt
    26521 ggaaatcaac taactgcaga agatatccgt aaggctaaag ctattatcat tgcagcagac
    26581 aaggccgttg aaatggatcg atttgatgga aaaccattga tcaatcgtcc agttgctgac
    26641 ggtatccgta agacagaaga gctaattaac ttggctcttt caggagatac tgaagtctac
    26701 cgtgccgcta atggtgccaa agctgcaaca gcctctaacg aaaaacaaag ccttggtggt
    26761 gccttgtaca aacacttgat gagtggtgta tctcaaatgt taccattcgt tatcggtggt
    26821 ggtatcatga ttgcccttgc cttcttgatt gacggtgctt tgggtgttcc aaatgaaaac
    26881 cttggcaatc ttggttctta ccatgagtta gcttctatgt ttatgaaaat tggtggagct
    26941 gcctttggtt tgatgcttcc agtctttgcg ggttatgttg cctactctat tgctgaaaaa
    27001 ccgggtttgg tagcaggttt cgtggctggt gctattgcca aagaaggttt tgcctttggt
    27061 aaaattcctt atgccgcagg tggtgaagca acttcaactc ttgcaggtgt ctcatctggt
    27121 ttcctaggtg cccttgttgg tggatttatc gcaggtgcct tggttcttgc catcaagaaa
    27181 tacgttaaag ttcctcgttc actcgaaggt gctaaatcaa tccttctatt gccacttctt
    27241 ggaacaatct tgacaggatt tgttatgcta gctgtgaata tcccaatggc tgcaatcaac
    27301 actgctatga atgacttcct aggcggtctt ggaggaggtt cagctgtcct tcttggtatc
    27361 gtccttggtg gaatgatggc tgttgacatg ggtggaccag ttaataaagc agcttatgtc
    27421 tttggtacag gtacgcttgc agcaactgtt tcttcaggtg gttctgtagc catggcagca
    27481 gttatggctg gaggaatggt gccaccactt gcaatctttg tcgcaactct tcttttcaaa
    27541 gataaattta ctaaggaaga acgtaactct ggtttgacaa acatcatcat gggcttgtca
    27601 tttatcactg agggagcgat tccatttggt gccgctgacc cagctcgtgc gattccaagc
    27661 ttcatccttg gttcagcagt agcaggtgga ctcgttggtc ttactggtat caaactcatg
    27721 gcgccacacg gaggaatctt cgttatcgcc cttacttcaa atgctctcct ttacctcgtt
    27781 tctgtcttgg taggagcaat cgtaagtggt gtggtttatg gttacctacg caaaccacaa
    27841 gcataaaaaa tagaaaaatg aaaagattgg accgtttggt gcagtctttt tctcttcccg
    27901 aaatgcctgt gaaatatggt ataatagaag aatggcaaac aagaatacaa gtacaacaag
    27961 acggagaccg tctaaagcag aactggaaag aaaagaagcg attcaacgaa tgttgatttc
    28021 gttaggaatt gcgattttat tgattttcgc agccttcaaa ttaggggctg caggtataac
    28081 cctttataat ttaattcgct tgctagtggg tagcctagct tatctggcga tattcggcct
    28141 attaatctat ctcttctttt tcaagtggat acgaaaacag gaaggactct tatctggctt
    28201 tttcaccata tttgctggct tactcttgat ttttgaggcc tacttggttt ggaaatatgg
    28261 tttggacaag tccgttctaa aagggaccat ggctcaggtt gtgacagatc tgactggttt
    28321 tcgaacgact agctttgctg gagggggctt gatcggggtc gctctttata ttccaacagc
    28381 ctttctcttt tcaaatatcg gaacttactt tattggttct atcttgattt tagtgggttc
    28441 tctcctagtc agcccttggt ctgtttacga tattgctgaa tttttcagta gaggctttgc
    28501 caaatggtgg gaagggcacg agcgtcgaaa agaggaacgc tttgtcaaac aagaagaaaa
    28561 agctcgccaa aaggctgaga aagaggctag attagaacaa gaagagactg aaaaaacctt
    28621 actcgatttg cctcctgttg atatggaaac gggtgaaatt ctgacagagg aagctgttca
    28681 aaatcttcca cctattccag aagaaaagtg ggtggaacca gaaatcatcc tgcctcaagc
    28741 tgaacttaaa ttccctgaac aggaagatga ctcagatgac gaagatgttc aggtcgattt
    28801 ttcagccaaa gaagcccttg aatacaaact tccaagctta caactctttg caccagataa
    28861 accaaaagat caatctaaag agaagaaaat tgtcagagaa aatatcaaaa tcttagaagc
    28921 aacctttgct agctttggta ttaaggtaac agttgaacgg gccgaaattg ggccatcagt
    28981 gaccaagtat gaagtcaagc cggctgttgg tgtaagggtc aaccgcattt ccaatctatc
    29041 agatgacctc gctctagcct tggctgccaa agatgtccgg attgaagcac caatccctgg
    29101 gaaatcccta atcggaattg aagtgcccaa ctccgatatt gccactgtat ctttccgaga
    29161 actatgggaa caatcgcaaa cgaaagcaga aaatttcttg gaaattcctt tagggaaggc
    29221 tgttaatgga accgcaagag cttttgacct ttctaaaatg ccccacttgc tagttgcagg
    29281 ttcaacgggt tcagggaagt cagtagcagt taacggcatt attgctagca ttctcatgaa
    29341 ggcgagacca gatcaagtta aatttatgat ggtcgatccc aagatggttg agttatctgt
    29401 ttacaatgat attccccacc tcttgattcc agtcgtgacc aatccacgta aagccagcaa
    29461 ggctctgcaa aaggttgtgg atgaaatgga aaaccgttat gaactctttg ccaaggtggg
    29521 agttcggaat attgcaggtt ttaatgccaa ggtagaagag ttcaattccc agtctgagta
    29581 caagcaaatt ccgctaccat tcattgtcgt gattgtggat gagttggctg acctcatgat
    29641 ggtggccagc aaggaagtgg aagatgctat catccgtctt gggcagaagg cgcgtgctgc
    29701 aggtatccac atgattcttg caactcagcg tccatctgtt gatgtcatct ctggtttgat
    29761 taaggccaat gttccatctc gtgtagcatt tgcggtttca tcaggaacag actcccgtac
    29821 gattttggat gaaaatggag cagaaaaact tcttggtcga ggagacatgc tctttaaacc
    29881 gattgatgaa aatcatccag ttcgtctcca aggctccttt atctcggatg acgatgttga
    29941 gcgcattgtg aacttcatca aggctcaggc agatgcagac tacgatgaga gttttgatcc
    30001 aggtgaggtt tctgaaaatg aaggagaatt ttcggatgga gatgctggtg gtgatccgct
    30061 ttttgaagaa gctaagtctt tggttatcga aacacagaaa gccagtgcgt ctatgattca
    30121 gcgtcgttta tcagttggat ttaaccgtgc gacccgtctc atggaagaac tggagatagc
    30181 aggtgtcatc ggtccagctg aaggtaccaa acctcgaaaa gtgttacaac aataaaaaaa
    30241 tagcttcttt ccgagtttgg agggaagcta ttttagtggc tattgattgc ttttattttc
    30301 tgaagttggc gcattggact gtttttcgtt ttcagtagca ggtttacttg aagcaggagt
    30361 agaagagtcc tgagttgctg ttttctgatc ttcttttttc tcttccttga cgctagattt
    30421 tggtgtttcc tcttgctgtg ttttttcttg actagtgtta gtctctttag ttggactggt
    30481 gttttcctta ggggattcct tttggatttc tttgacaatg gttgtcgtct ggcttgtcgt
    30541 aggttctttt ttaatatttt tgttattatc caaggcgttc atgatcgtga tacccgcggt
    30601 aatcaagcca aggatactag cgattgtagc aacggttttt tgaaagactg taaagccttt
    30661 tttgatgtgt tctgtttttg gttttgaagt tctacgatag ttagacatac attctctcct
    30721 ttgattatga tttattatac tctgtttctt taaaaaaatc ttaaaaaaag agaaattgcc
    30781 ctttcttgtc gcaggctccg tttcatgata caatagaagg agtgatttta gaaagcgtga
    30841 gaaacatgat ttactttgat aattcggcga cgaccaggcc ctatccagaa gcccttgaaa
    30901 cctatatgca ggtggcttca aaaattttag gaaatccatc tagtctccat cgtttgggag
    30961 accaggcaac acgaatttta gatgcttccc gtcaacagat tgcagattta atcggtaaga
    31021 aaagtgatga aatcttcttt acatctggtg ggacagaagg ggataactgg atcatcaagg
    31081 gagtagcatt tgaaaaagcc cagtttggca agcacatcat cgtatcagcc attgaacatc
    31141 cagcagttaa ggaatcagcc ctctggttga aagctcaagg ttttgaagtg gattttgctc
    31201 cagttgataa caaaggattt gtggatgttg aggcgctaga agatttgata agacctgata
    31261 cgaccctcgt ttccatcatg gcagttaaca atgaaattgg ctctgttcag cccattgagg
    31321 ctatttcaaa actattggca gacaagccaa ctatttcctt ccacgttgat gcggttcagg
    31381 cgcttgccaa gattccgact gaaaagtatc tgacagaacg agtggatttc gcgactttct
    31441 ctggtcacaa gttccacgga atccgtggtg ttggttttat ctatatcaag tctggcaaga
    31501 agattacgcc tcttttaaca ggtggtggtc aggaacgtga ttaccgttcg acaactgaaa
    31561 atgtggcagg aattgcagcg accgctaagg ctctccgttt atctatggaa aagctagata
    31621 tctttaggag caagactggg cagatgaagg cagtgattcg tcaagcactt ctggactatc
    31681 cggatatatt tgtcttttca gatgaggaag acttcgcccc tcatattctg acttttggaa
    31741 tcaagggtgt tcgtggtgag gtcattgttc acgcctttga agactatgat attttcatct
    31801 caacgacctc ggcttgttcg tccaaggctg ggaaaccagc cggaaccctg attgctatgg
    31861 gagtggacaa ggataaggct cagtcagctg tgcgtcttag tctagacctt gaaaatgata
    31921 tgagtcaggt cgagcagttc ttgaccaagc taaaattaat ttacaatcaa actagaaaag
    31981 taagatagga gcattcatgc agtattcaga aattatgatt cgctacggtg agctgtcaac
    32041 caagggcaaa aatcgtatgc gtttcatcaa taaacttcgc aataatattt cagacgtttt
    32101 gtctatctat ccccaagtta aggtaacagc agatcgcgac cgtgcccacg cttacctcaa
    32161 tggagcagat tacacagcag tagcagaatc actcaaacaa gtatttggaa ttcaaaactt
    32221 ttcccctgtt tataaggttg aaaaatctgt agaagttctg aagtctgctg tccaagagat
    32281 tatgcaggac atctacaagg aaggcatgac ctttaaaatc tctagcaagc gtagcgacca
    32341 cacctttgaa ttggacagtc gtgaactcaa ccaaacgctt ggaagggctg tattcgaagc
    32401 cattccaaac gtacaagctc aaatgaaaag tcctgacatc aatcttcagg tggagatacg
    32461 tgaagaagca gcctatcttt cttatgaaac cgttcgaggg gcaggtggat taccagtggg
    32521 aacttctggt aagggcatgc tcatgttgtc agggggaatc gattcccctg tagctggcta
    32581 tctagcgctt aaacgagggg tagatataga ggcagttcac tttgccagcc caccttacac
    32641 gagtcctggt gctcttaaaa aagcccaaga tttgacccgt aaattaacca aatttggggg
    32701 aaatatccag tttatcgaag ttccttttac agagattcaa gaggaaatca aagccaaagc
    32761 gccagaagcc taccttatga ccttgacgcg tcgttttatg atgcgtatta ctgaccgtat
    32821 tcgtgaggta cgaaatggtt tagttatcat caatggggaa agtctaggtc aagtagccag
    32881 ccaaaccctt gaaagtatga aggctatcaa tgctgttacc aacactccca tcattcgtcc
    32941 tgtggttacc atggacaagt tggaaatcat tgacatcgcc caggaaatcg atacctttga
    33001 catttcaatc caaccgtttg aagactgttg taccattttt gcaccagatc gtccaaaaac
    33061 aaatcctaaa attaagaatg cggagcagta cgaagcgcgt atggatgttg aaggcttggt
    33121 tgagcgagca gtggctggaa tcatgattac tgaaatcaca cctcaagccg aaaaagatga
    33181 agttgatgac ttgattgaca atctgctcta attcagaaaa tccaaaagaa tagcgaaaat
    33241 cagtaaaaaa agttagtttt ttctctaaaa acaggtaaaa aactaacttt ttttattttt
    33301 atgatataat gatataaaat tttgaatata gagagttttc tggcaatgaa tcaatcctac
    33361 ttttatctaa aaatgaaaga acacaaactc aaggttcctt atacaggtaa ggagcgccgt
    33421 gtacgtattc ttcttcctaa agattatgag aaagatacag accgttccta tcctgttgta
    33481 tactttcatg acgggcaaaa tgtttttaat agcaaagagt ctttcattgg acattcatgg
    33541 aagattatcc cagctatcaa acgaaatccg gatatcagtc gcatgattgt cgttgctatt
    33601 gacaatgatg gtatggggcg gatgaatgag tatgcggctt ggaagttcca agaatctcct
    33661 atcccagagc agcagtttgg tggtaagggt gtggagtatg ctgagtttgt catggaggtg
    33721 gtcaagcctt ttatcgatga gacctatcgt acaaaagcag actgccagca tacggctatg
    33781 attggttcct cactaggagg caatataccc agtttatcgg tttggaatac caagaccaaa
    33841 ttggttgctt gggcgttttt tcatctgcaa actggctcca ccaagaagcc tttaaccgct
    33901 atatcgagtg ccagaaacta tcgcctgacc agcgcatctt catctatgta ggaacagaag
    33961 aagcagatga tacagacaag accttgatgg atggcaatat caaacaagcc tatatcgact
    34021 cgtcgctttg ctattaccat gatttgatag cagggggagt acatctggat aatcttgtgc
    34081 taaaagttca gtctggtgcc atccatagtg aaatcccttg gtcagaaaat ctaccagatt
    34141 gtctgagatt ttttgcagaa aaatggtaag ttaagaaagg aaaaaacgaa atgcatattg
    34201 aacatcttag ccactggagt ggtcatctta accgtgaaat gtaccttaac cgttatggac
    34261 atggtgggat tccagttgtg gtctttgctt catcaggtgg tagtcacaac gaatactatg
    34321 attttggcat gattgatgcc tgtgcttcct ttatcgagga aggccttgtc cagttcttta
    34381 ccctatctag tttggatagt gagagctggt tggttacttg gaaaaatgct catgaccaag
    34441 cggaaatgca ccgtgcctac gaatgttatg tgattgagga ggccattctt ttatcaagca
    34501 caagacaggt tggtttgatg gcatgatgac gacaggttgc tctatgggag cctatcatgc
    34561 actcaatttc ttcctccagc atccagatgt ctttaccaaa gtgattgctc tcagtggtgt
    34621 ttacgacgca cgtttctttg tcggtgatta ctacaacgat gatgctattt accaaaactc
    34681 gccagtagat tatatttgga accaaaacga cggctggttt attgaccgtt accgtcaggc
    34741 agagattgtg ctgtgtacgg ggcttggagc ctgggaacaa gatggtttgc catcctttta
    34801 caagctcaaa gaagcctttg acaagaaaca aattccagcc tggtttgctg aatggggaca
    34861 tgatgtcgcc catgactggg aatggtggcg taaacaaatg ccttatttcc tcggtaatct
    34921 ctatttataa aaggagttac ctatgaatta ccttgttatt tctccctact atccacaaaa
    34981 ctttcaacag tttaccatcg aactagctaa taaaggcatc acagtcttgg gaattggtca
    35041 agagtcttac gagcaattgg atgagccctt gcgcaatagc ttgaccgagt attttcgtgt
    35101 tgataatctt gagaacatag atgaagtcaa acgtgcagtt gcttttctct tttataaaca
    35161 tggtccaatt gaccgcatcg agtctcacaa tgaatactgg cttgagctag acgcaacact
    35221 cagagaacaa ttcaatgttt ttggtgccaa accagaggat ctcaaaaaga cgaaatataa
    35281 gtctgaaatg aagaaacttt tcaaaaaagc aggtgttcct gtggtacctg gagctgttat
    35341 caagacggaa gcagatgttg atcaagcagt gaaagaaatc ggtcttccaa tgattgccaa
    35401 acctgataat ggagtgggag cagccacaac ctttaaactt gagacagaag acgatatcaa
    35461 tcacttcaag caagaatggg accattcaac cctttatttc tttgaaaaat ttgtcacttc
    35521 cagcgaaatc tgtacctttg acgggctcgt ggacaaggat ggaaagattg tcttctcaac
    35581 aacctttgac tacgcctata caccgcttga cctcatgatt tataagatgg acaattctta
    35641 ttatgtgctc aaggatatgg atcctaaact gcgcaagtat ggggaagcaa ttgtcaaaga
    35701 atttggtatg aaagaacggt ttttccatat tgagttcttc cgtgaggggg acgattatat
    35761 taccatcgag tacaataacc gccctgcagg tggttttacc attgatgttt ataactttgc
    35821 tcattccttg gacctctatc gtggctatgc agctattgtc gcaggagagg agttcccggc
    35881 gtcagacttt gaaactcagt attgtttggc tacttctcgc cgtgcaaatg ctcactatgt
    35941 ttattcagaa gaggatttgc ttgccaaata tagccagcag ttcaaagtta aaaaagtcat
    36001 gccagctgcc ttcgcggaac ttcaaggaga ttacctgtat atgctgacca ctccgagtcg
    36061 acaagaaatg gagcagatga ttgcagattt cggacaacgt caagaataag aactatcgga
    36121 ttaaggaaat taactccctt aatccttttg ttttgtctga taaaaaataa gagcatccca
    36181 acaaggtagc tatcataaaa cttgttcgat aactatttga agcaggatta ggtggtcaga
    36241 aattgaattt taatatttca attgagtcat agtattgtgt ttgcgtatcc ttaaatcagc
    36301 taaaaggatc catgacgaca cctatacgat atagttttca agataccaaa caagtctatt
    36361 aatactcaat gaaaatcaaa gagcaaacta ggaagctagc cgcaggtttc tcaaaacact
    36421 gttttgaggt tgtggataga actgacagag tcagtatcat atacctacgg caaggtgaag
    36481 ctgacgtggt ttgaagagat tttcgaagag tataaaatat tcaggtgacg catagatata
    36541 gttaattgaa gctttgtttg aaatctgata aaataatgat attactaagt tttaaaaact
    36601 aaagaaaagg gaagatatga ttacaggcga attaaaaaat aaaatcgatc agctgtggga
    36661 aattctttgg acagaaggaa acgcaaatcc tttaacaaat attgaacagt tgacttatct
    36721 cttatttatg aaagatttgg atagtgtcga gcttggacgt gaaagtgatg ctgaatttct
    36781 agggattcct tatgagggag tttttccaaa agataaacct gaataccgtt ggtcaacttt
    36841 taaaaatata ggagatgctc aggaagttta tcgtttaatg actcaggaga tttttccgtt
    36901 tattaaaaat ctcaaggggg atacagatga tacagccttt tcacgatata tgcgagaagc
    36961 tatttttcaa ataaataaac ctgctacgct tcaaaaggca atttctatct tagatgtttt
    37021 tccaactagg ggattagatg tagattttga taatgacaaa caaagtatta ctgatatcgg
    37081 agatatctat gaatatctgt tatcaaaatt gtcgaccgca ggtaaaaatg gacagttccg
    37141 tacacctcgt cacatcatcg atatgatggt tgagttgatg caaccgacta tcaaagatat
    37201 catctcagat cccgctatgg gttctgctgg cttcttagta tctgctagcc gttacttaaa
    37261 gcgtaagaaa gatgaatggg aaaccaatac agataatatc aatcattttc ataatcagat
    37321 gtttcatgga aatgatacgg atacgactat gttgagactt ggggcgatga acatgatgct
    37381 acatggagta gaaaatccac aaatcagtta ccttgactcg ctgtctcaag ataatgaaga
    37441 agccgataaa tatactttgg ttttagcaaa tcctcctttt aagggctcac ttgactacaa
    37501 ttcaacctct aatgaccttc ttgcaaccgt aaaaaccaaa aaaacagaat tactctttct
    37561 ttctcttttc ttgcgaactt taaaaccagg tggacgagca gcagttatcg tacctgatgg
    37621 tgtccttttt ggttcgtcta aagctcataa aggaattcgt caggaaattg tagagaatca
    37681 taagcttgat gctgtaatct caatgcctag tggtgtgttc aagccttatg ctggagtttc
    37741 aactgctatt ctcatcttta caaaaactgg taatggtggt actgacaaag tctggtttta
    37801 cgatatgaaa gcggatggtt taagtttgga tgataagcga caaccgatta gcgacaatga
    37861 tattccagat attatcgaac gctttcatca tcttgaaaaa gaagcagaac gtcagagaac
    37921 ggatcaatct ttctttgttc cagttgctga gataaaggaa aatgattatg atttgtctat
    37981 caataaatat aaagagattg agtatgaaaa agttgagtat gaaccaacag aggtcatctt
    38041 aaagaaaatc aatgatttag aaaaagaaat tcaagctggc ttggctgaat tagaaaaatt
    38101 actcaagtag ggaggtggct gtatgaaaaa agtgaagttg ggggaagtct tatctctaaa
    38161 aaaaggaaag aaagccactg tacttgctga acaaacaact ctaagccaac gttatattca
    38221 aatagatgat ttaagaaata ataataattt aaaattcact gaaagtttaa atatgactga
    38281 agcactccca gatgatattc taatagcatg ggatggtgct aatgcaggaa cagttggcta
    38341 tgggttatcg ggagctgttg gtagtacaat tacggtctta aaaaagaatg agcgatacaa
    38401 agaaaaaatt atatcagatt acttgggagt ctttttggaa agtaaatcgc agtatttacg
    38461 agatcattca acaggtgcaa ctattcctca tttaaacaag aatatattac ttgatttaca
    38521 attagaattg ctaggtatcg aagaacaaga gaacattatc tgtattctta atacgattaa
    38581 aaggcttatt actaaaagaa aatttcagtt agatgaacta aacttgctcg tcaaattccc
    38641 gatttaacga gatgtttggg gatcctttaa ataataacaa gaaatttgca gtaaaaacgg
    38701 gacaacagtg ttttaaattt tcaagtggaa aatttcttga taaacatgat agagtttttg
    38761 aaggttatcc tgcctatggt ggaaatggca ttgcttggaa aagtcgaaaa tatttaattg
    38821 ataatcctac tatcatcatt ggtcgtgtag gtgcatattg tggtaatgta agaactaccc
    38881 acggtaaggt atggataagt gacaatgcta tatatataaa agaatttaag aattccgatt
    38941 tcaatcttgt atttttatta gaattaatga aagtaattga ttttagtaaa tttgctgatt
    39001 tctcaggtca accaaagata actcaaaaac cattagaaaa tcagaaatat atcctccccc
    39061 ctctagccct caaaaatgag ttcgcagact ttgtagccct ggtcgacaaa tcacaattgg
    39121 caatccaaaa atctctggaa gaacttgaaa ctttgaagaa atctctgatg caggagtatt
    39181 ttggctgata ttctgccatt gtaattacgg taatgatttg ttataatact tcaaaggagg
    39241 aaatcagatg gtagtaaaaa caagaaaaca aggaaattca atcaccatta cgattccaag
    39301 tgaatttaat attccaagtg gtgttaaata cgaagcgaaa ttgttaccaa gtggtgagat
    39361 tatctttact cctgaagaat tggggcagca ggtttcttat gtatctgatg atgcctttga
    39421 cttaaattta gataaaatat ttgacgaata cgacgatgtt ttcaaagctt tggtggaaaa
    39481 atgacaatct atctgacaga aaagcaaatt gaaaaaataa atgctttagc aattcaacgg
    39541 tattctccaa atgagaaaat tcaaacagtt agttcttctg ccttaaatat gattgtgaac
    39601 ttaccagaac aatttgtctt tgggaagtct ctttatccaa caatttttga taaagcaacg
    39661 atactatttg tccaattgat aaagaagcat gtttttgcta atgctaataa aagaactgct
    39721 ttcttcgttt tggtcaaatt tttacaatta aacggctatc gtttttctgt aacggtagaa
    39781 gaagcagtaa aaatgtgtgt aaccatcgca gtagaagctt taactgatga aaaaatgaca
    39841 agctactcca aatgggtttc tgaacattct gttagagaaa aggtcaaaaa gtaacctagt
    39901 atgctggatt tgaatgagca caagaaaata aatgaacaga caatattaga attctgtaat
    39961 gcagaaactg atattgtctc tttttattga tgaataagaa agtgagaaat tatggaatca
    40021 aaagttacaa ttatcatgca agaaatgtta cctcttttaa ataatgaaca attactagcg
    40081 ttgagagaga gtttagaaca tcatctagta gacggaaaaa agcagcagaa gtattcgaat
    40141 aataacctgt tgcaactatt tattaccgcc aagcaggtag agggctgtag ctcaaaaaca
    40201 attcgttatt accagaggac gattgaaaac ttgtttaatg ctattaaaga gtctgtgaca
    40261 caactcacaa cagatgattt aaggagttat ttagcaaatt accagtctga aaaggattgt
    40321 agtaaggcaa atttagacaa tattaggcgt atattgtctt ctttttttgc ttggcttgag
    40381 caagaggaat atatcattaa aaatcccatt cgacggataa agaaaattaa gactgagcaa
    40441 aatgtgaagg aaacttatac tgatgaacat ttggaaatta tgcgtgataa ctgtgaaaat
    40501 ttgagagatt tggcaataat agacctacta gcatcgacag gtatgcgtgt aggggagctt
    40561 gtacagttga atcgttcaga tattgatttt gaaaacagag agtgtgttgt ctttggtaaa
    40621 ggaaagaagg agagaccagt atattttgac gctcggacga aaattcattt aagaaattat
    40681 cttaacgaca gaaaagatag tcaccctgct ctttttgtaa cgctagttgg aaaagcccag
    40741 agacttggaa ttgctggtgt agagattcgc ttaagaaagt taggagacaa actcggcata
    40801 caaaaggttc acccacataa gttcagaaga actttagcga ctaaggcaat tgataaaggt
    40861 atgcctatcg aacaagtcca aaaactgcta ggtcatagca agattgacac aaccttggcc
    40921 tatgccatgg tcaatcaaaa taatgtcaag cattcacacc aaaaattcat ctcttaaaag
    40981 caaatcccga tttaacgaga tgtttgggga aaataaaata tttgaaagca ttgataactt
    41041 atttgatatt atagatggtg ataggggcaa aaattatcct aaatcagatg agttgtttag
    41101 tgaggagtac tgtttatttt taaatacaaa gaatgttact aaaaacggat tttcattcga
    41161 tacaaagcaa tttatcacta aaacaaagga taaattactt cgaaaaggca aacttgagcg
    41221 ttatgatata gtcttgacaa caagaggtac tgttggaaat gtagcgtact acgatgaatt
    41281 aataaaatat aaacatttac gtataaattc aggtatggta atattacgtc ccaagacacc
    41341 aaatctaaat cagaaattta ttatccatgt tttaaggaat aataattata gtcgagtgat
    41401 atcaggaagt gctcagcctc agttaccaat tacaaaatta aaaaaaatac ttctccccct
    41461 ccccccacta gccctccaaa atgagttcgc agactttgta gtccaggtcg acaaatcaca
    41521 atttgcttgt gagatagcta taaaagtgtg gagaaatagc ttgaaattta gtataatata
    41581 gctaaactat ttgtttaaag tgagaaaaaa atgggaaatt ttagctttct tttaaaaaat
    41641 gacgaatatg aatctttttc aaaaccttgc attgaagctg agaatatgat tgctacatca
    41701 actgtggcta ctgcctttat ggcgcgtcgt gctttagagc aggctgtcca ttggatatat
    41761 agtcacgatt catatttaga agctccctat cgtgctactc tatcttcttt agtatgggat
    41821 gatgatttta gggatatcgt agattctgaa ctccacaagc agatagttct gttgattcgg
    41881 tggggaaacc atgctgctca tggtggtgaa attaaggaac gagaagcgat tttagctttg
    41941 catcatttgt atcagtttgt taattttatc gattattgtt acagcaatga gtttgtggag
    42001 cgttattttg atgagaagtg cttaccactt tcagcaaaca tcaaataccg agaaactcca
    42061 caatctatga taaagttaca agacagttta ccagaactgc ctgattttca tgaacagatg
    42121 gctgctcagt ccgtagaagt tcaagagact tatactgaaa aacgtgagac tgcagcgcaa
    42181 cggcaagatg tgcctttcca tattgatcaa ttatctgagg cagagacaag aaagctcttt
    42241 attgatatcg atctccgttt agcaggatgg atatttgaag aaaactgtcg tgttgagata
    42301 gccgttgatg gtctcaagca cggttcagga attggttact gtgactatgt actttatggt
    42361 aaaaatggga aaattttagc gattgtggag gctaaaaaag cctctgtcaa tccagaagta
    42421 ggggaagtac aggtcaaaga atatgctgaa gctttggaga aacatatcgg ctatcagcca
    42481 atttgcttta ttacaaatgg gttgaagcac tatatacttg atggtccgaa ccgccgccag
    42541 attgcaggct tttactctca agaagaattg caattagtga tggatagacg tcatcttcaa
    42601 aaaccgcttg aggatatttc tagtaaaatt agggacgata tttccgggcg tcactaccaa
    42661 aaacatgcca ttgcaagcgt ttgtgaagct ttctctaatc atcgtagaca ggcacttttg
    42721 gttatggcaa ctggggcggg gaaaactcgt acagcagttt ctctagttga tatcttatca
    42781 cgtcataact gggtaaaaaa cgttctcttc ttagccgata gaacttcctt ggttaagcaa
    42841 gcctatgatt cgtttagaaa attactccca gatctttccg tttgtaactt cttagaagat
    42901 aaagaaggag ctcaatcaag tcgtatggtc ttttcaactt atccgaccat gattggagcg
    42961 attagtggtc aagaagaagt aaatcaacgc ccttttactg ttgggcattt tgaccttatc
    43021 ataattgacg aatctcaccg ttctatttat cagaaataca agtccatttt tgattatttt
    43081 gatgcaagaa ttgtaggctt aacagctact ccgcgtcaag atttagataa aaacacctat
    43141 ggattcttta atttggagaa tggggttcca acatatgcat atgatttgga agaggctgtt
    43201 aaagacggat atttagtagc ctatcattct atcgaaacca aactgaaact acctacggat
    43261 ggtctacatt atgatgattt gtccgaagaa gaaaaggaac attttgatag caaatttgaa
    43321 gacgatagct gtgaaaaaga tattgatggg agtgtattta attcctttat tttcaataaa
    43381 agtacagtag aaattgtttt aaatgaactc atgacaagag gaattcagac agcctcgggt
    43441 gatgaaattg gtaaaactat tatttttgct aaaaatcatg atcatgcgga atatatcaga
    43501 ggtattttta acaaccgcta tcctgaaaaa gggagcgact atgctcaggt gattgattat
    43561 agtattaagc attatcagac cttgattgat gattttaaaa ttaaggagaa gtatcctcaa
    43621 attgcgattt ctgtcgatat gttagataca ggtattgatg taccagaggt tgttaattta
    43681 gtcttcttca agaaagtacg ctctaaaact aagttttggc agatgattgg tcgaggaacc
    43741 cgtctatgta aagatttatt tggacctgag caggataagg aaaacttctt ggtatttgat
    43801 tatggggaca attttgatta ttttcgtgca gatccaagag atggagaggg tcgtcacatt
    43861 gtttcgctga ctcagcgttt atttaatatc aaagtggact tgattcgaga acttcaggga
    43921 ctccaatacc aagaagatca gtttgcgaga gcataccgtc agcagcttgt ctcggaactt
    43981 caaggtcgta tagagagctt aaatgagttg gacttcaggg ttcgtatggt tttagataca
    44041 gtttatagct ataagaaatt ggaaagttgg cagaatctaa ctgctgttac aagtgaaacc
    44101 attcaaaaaa atctctctcc gcttttattt gatgaagata aagaagatga gatggcgagg
    44161 agatttgatt tgtggttgct tcatattcag ttggggcaac tgacagctaa atcttccact
    44221 gttcatattt cccaagtgat gaagacggct agagctcttt ctgctattgg caatatcccg
    44281 caggtttttg agcaggctga aattatcagg aaagtacagg agcctgaatt ttggaaagaa
    44341 gttaacttgt ctgatttgga aaaaattcgt cttgctattc gagatttatt acagtttttg
    44401 gataaaacag accgtaaacc ctactatgtt aactttgaag atcgtatact ctccactgtt
    44461 cacgagacca cagcattttt gcaggtcaac gatcttcggt cttacaatga aaaagttgag
    44521 caatatttga aaactcatct ggatgaggag tccatttcta agctatacca taataaaaag
    44581 ttgacatctg atgatatgct tgcacttgaa aaattgcttt gggaaaaatt aggtagtaaa
    44641 gcagactacc aaagtcatta tgaaaataag gcaattccga gattggttcg tgagattatt
    44701 ggcttagata gagagtctgc caatcgtatt ttttctaaat ttttgtcgga tgagaatctt
    44761 aatgccaggc agatttcatt tgtaaaattg attgtagact acattgtaga aaatggtttt
    44821 ttagagacga aagtgttaac gcaagagccg tttaaatctt atggttctgt tcaactactc
    44881 ttccaacacc aactaccagt acttcgtaat attgttcaaa tcattgaact tatcaataat
    44941 cgagctggag aagcggctta aattctaaag tgattgccat gctgagactc atttaaaatt
    45001 aaaaagagta gaaatttatg ctatatatga gaagttttat taggaagaat gtcatcgttt
    45061 tcctagaata cagtatcagt tgttaagtgg ttgataaatt tcaaagtaga tacttgtacc
    45121 acgatgtttg ttgatcgagt tattaacaaa agagctactt tgattttaaa gaaatagaaa
    45181 acaaaaagct gagcaagaat tcaattgcag gagaaaatga aataatactc aatgaaaatc
    45241 aaagagcaaa ctaggaaact agctgcaggc tgctcaaaac actgttttga ggttgtagat
    45301 aagactgacg aagtcagctc aaaacatggt tttgaggttg tagatgaaac tgacgaagtc
    45361 agtaaccata tatacggcaa ggcgacgttg acgcggattg aagagatttt cgaagagtat
    45421 aaatcttctt aggataaagc aaaacgcata gtatcaaggg ttttcaacac ttgatactat
    45481 gcgttttctg atgttaaaga ctttctacca ggttttttaa aagcataatt gttagttgta
    45541 gtcatttatt attcttcaaa gaaaaatggt ggggcgaatt ttttcagttc ttcaaagcac
    45601 ttttgagcag tatctgcatc ttcacagatg ataagacaga catcattacc acaaagggta
    45661 gcgatagcgt cagggaagct caaagtatca atgatagaac caaaggattg agccagtcca
    45721 ggaagggttt ttagtaggac ttggtgttga actgggcgca tccagacaag ggcgtcttcc
    45781 atgtagagtt cgagacgttt ttcccatttt gagatggaac cattgttaag aacataataa
    45841 gcgctatctt cttcgcggac ttttgatagg ttcatatttt tgatgtcgcg tgagagggtt
    45901 gcctgggtta cttgaatgtc gttctcagca agaagggctt gcaactcagc ctgtgtatga
    45961 atcttgtttt ttgtgataag agcgcgtata agttggtggc ggtgttctga tttattcata
    46021 ataatgtaac tccttttagc aaggtaaggt aagcatggac tgagcgaggt cgacagtcaa
    46081 gtggtagtct gtattgtcac ggatggtgat ttcaaagtca gtagtataga ggactaaacg
    46141 gagagtgtct ccttctttta gcttgtaaat agttggctgc agttcaaatt gaacgtccat
    46201 ccattcatct gcagtaatat cctctactaa cagtaaatca tttctatttt gtaaattaag
    46261 gtaacctttt gtcacgactc gttgtgcctc tggtctaaat ggcaattcac agagattttc
    46321 caacatgtga tagcgaccgt tgtcaatggt tctagcactt aaaatagctg gataaggttg
    46381 taggtattta ttttgcccaa attctagcag ttgggcagat aagagcccct tgtttgtact
    46441 ggatttgata cgaagattga gctgagcgcg accgtttagg tggagatctt tagtcacagg
    46501 aaggttaata gtaatctgat tagctttccc ttgatagagc tctgtattga agatttggta
    46561 tgtcttacca tagcgctcaa aatccttatc tgggtactgg ttttgaatag cttgctcttc
    46621 ttgaccaagt gagaaggttt cacagttttc ttgcccaccg aagttatcaa gtgataacca
    46681 agtctgtgga gctgtattgt cctgccagat aacagtagga agttgaaagt ctgtttcctg
    46741 tcctagtaat ttcttggtca ataaggcatt tatggactca cggaagtcaa ttgattgcca
    46801 attgttcatg taaacatggg caccattatg gaaaaagaga tgcttgtgta tatgagtagg
    46861 aagagcatgg aacatctggt aaacatgaag tggtttgaca ttccaatcct gagaaccatg
    46921 agtaaagaca acctctgcct ttactttatg ggcattgagc agataattgc ggtcatgcca
    46981 aaactgattg tagtccccag tttttcggtc tagctgagct ttcacttttt ctaagtcagc
    47041 ttggtgagct tcattgccac ggatatagtc gccagctaag agattacgag aataggttaa
    47101 ctcagcaagg gagtcaaagt cctcacctgg ataaccacct gggctagtca ccagaccgtt
    47161 ttcacggtag tagttgtacc atgatgaaat tcctgcctcg gcaatgataa cttctaaacc
    47221 atcgactcct gtagtcgcaa gaccattgga catggtacct agataggaaa gtcctgttgt
    47281 agcaactttt ccgtttgacc aatcagcctt gacttgacgc tggcgcgtgt gatcagtaaa
    47341 ggcacggcaa cggccgttaa gccaatcgat gacattttta taagcctcga tttgctggta
    47401 gtctccatta gtcatgaaac ctgtcgagtc tttggtacca acacctgaga catagagatt
    47461 ggcaaagcct ctcggaagga agtagtcgtt tagtgtatag ctagagttga tgtgagttag
    47521 cttttcctca gcctctgcta taagctcagc tttaccttgg ggttggacga gatttagttg
    47581 aggtttctct agctcaatct tgtgaggaag tttaacctca agctcgccct ccatcttgta
    47641 gagagccttg tcactagcct tgtcattggt tccctgatga taagggctgg ctgtcatgat
    47701 ggcagggatt tttccatcaa aacgagggcg aataatgcta acctttacta ggtctgatag
    47761 ccctttttgg tcagtatcga cacgagactc aacgtaaacg acttcacgaa tgacatcctg
    47821 gttagaaaaa gtagccaaac tcttgccgtt aaagtagtgg tagtcattat cctccggaat
    47881 aagaccatca ctaacaagtt ggtcgataag agtatttcct tttttggtgc gagtattgag
    47941 taactgatag agattttcaa tcaagtcacc atatataatg ggaaatccag tttctttacg
    48001 aaaaacgtca ctatcttcga agtcaaccaa ataagaaaag cctaaaagtt gaaaagcaac
    48061 agtataaaaa atatctgctg tcagttcatc ttctgattga aaaaatgtca gcaggtctgt
    48121 ttttttatca gctgctagga tagaaagtgg gtagttggtg tcttgataag tgaaaaagaa
    48181 acgacgtaaa aaggtttcaa gtgagtcttt gtgattggct gtattttgta aatcaaagcc
    48241 acattttttt agttcagata agacattttc ttttggaaaa ttgatataac tatattgatt
    48301 aaaacgcata gaacctccat atagaatgac agttaaggtt attatatcaa aaaaaaagca
    48361 gaaagggaat tgttaacttc aaaaggaaat aatccaataa aaatgaataa agtactaaat
    48421 tcaatataga gaacagagta acaataagaa taaatagata gggtataaaa gttctaggag
    48481 atttatatta tatgctttct atttttatat acaatatagt ataaatataa aaatgatgac
    48541 aaaaatacaa atgaatagaa aataaattag taagctgatg aaatttttct caagagaagc
    48601 catttatagg tgaaaatggt ataatatagt gagaaggata gaggagaagt gtaaattgat
    48661 cgcacaacta gatacaaaaa cagtctatag ttttatggaa agcgtcattt cgatcgaaaa
    48721 gtatgtgaga gcagctaaag aatacggcta cactcatttg gctatgatgg atattgacaa
    48781 tctttatggc gctttcgact ttctagagat tacaaaaaaa tacggcattc atcctttgct
    48841 agggcttgaa atgacagtgt ttgtagatga tcaggaagtg aatttgcgct ttttagctct
    48901 atctagtgtg ggctatcagc agttgatgaa gctttcgaca gccaagatgc agggggagaa
    48961 aacttggtca gtcctgtccc agtacctgga ggatatcgcg gtcattgtgt cttattttga
    49021 tagagttgag tcgttagaac taggctgtga ttactatata ggggtttatc cagaaacact
    49081 agcaagcgaa tttcatcatc ctatcttacc tctttatcgg gtcaacgctt ttgaaagcag
    49141 ggatagagaa gttcttcaag ttttaacagc gattaaagaa aatctaccgc tcagagaagt
    49201 tcccttgcgt tcgagacaag atgtctttat atcagcaagt tctttagaga aactattcca
    49261 agagcgtttt ccgcaagctt tggacaattt agaaaagctt atttcaggca tttcttacga
    49321 cttggatact agtctgaaac tgcctcgttt taatccagct agaccagcag tagaggagtt
    49381 gagagagcgt gctgaactgg ggcttgttca gaaggggttg actagtaaag aatatcaaga
    49441 tagactagac caagaattgt ctgttattca tgatatgggc tttgatgatt atttcttggt
    49501 tgtttgggat ttgttgcgtt ttggacgatc gaatggctat tatatgggaa tgggaagggg
    49561 ttctgcagta ggcagtttgg tttcttatgc cttagacatc acggggattg acccagtaga
    49621 gaaaaatctg atttttgaac gctttcttaa tcgtgaacgc tataccatgc ctgatattga
    49681 tattgatatc ccagatattt atcgtccaga ttttatcaga tatgttggta ataaatatgg
    49741 tagtaaacat gcggcacaaa tcgttacttt ttcaaccttt ggagccaagc aagctcttcg
    49801 agatgtcttg aaacgctttg gtgtgccaga gtatgaatta tctgcaatta ctaagaaaat
    49861 cagttttcgt gacaatctta agtcggccta tgagggcaat ctccagtttc gtcagcaaat
    49921 caatagtaag ttagaatacc aaaaagcttt tgagattgct tgcaagatag agggctatcc
    49981 aagacaaacc tctgtccatg cggctggtgt tgtaattagt gaccaagatt taaccaacta
    50041 tattcctcta aagtatggtg atgaaattcc actgactcag tatgatgctc atggagttga
    50101 ggctagcgga cttttgaaga tggactttct gggactacga aatttgacct ttgtccagaa
    50161 gatgcaagag ttgcttgctg aaatagaagg tattcacctt aaaattgaag aaatagattt
    50221 ggaagacaaa gaaacgttag atttatttgc ctctggaaat acaaaaggta tctttcaatt
    50281 tgagcaacca ggtgccattc gtctgcttaa gcgtgtgcaa ccagtctgtt ttgaagatgt
    50341 cgtcgcgact acttctctaa atcgaccggg tgctagtgac tatatcaata attttgtggc
    50401 aagaaagcat gggcaggaag aagtgactgt tctggatcca gtactggagg atattttggc
    50461 tccaacctac ggcataatgc tctatcagga gcaggttatg caggttgccc agcgatttgc
    50521 cggatttagt cttgggaaag ccgatatttt gcgtcgggct atggggaaaa aggatgcctc
    50581 tgccatgcat gagatgaggg tttcctttat tcaaggttca ttagaagctg gtcatactgt
    50641 ggaaaaagca gagcaggtct ttgatgttat ggagaagttt gcaggttatg gttttaacag
    50701 gtcacacgcc tatgcctact cagccttggc cttccagttg gcttatttta aaacacatta
    50761 tccagccatt ttttatcagg tcatgttaaa ttcttccaac agtgattact taatagatgc
    50821 acttgaagca ggttttgaag tagcctctct atccatcaac accattccct atcacgataa
    50881 aattgccaac aaggccatct atctaggttt gaaatccatt aaaggagtca gtaatgattt
    50941 agctctctgg attattgaaa atagacctta ttctaacatt gaagatttta tagctaaatt
    51001 acctgagaat tatctgaaac ttcctctgct agaacctttg gtaaaagttg gtcttttcga
    51061 ttcatttgaa aaaaatcgtc aaaaagtatt taataattta gctaatctat ttgaatttgt
    51121 gaaagagttg ggaagtttgt ttggagatgc tatttatagt tggcaggaat cggaagattg
    51181 gacggaacaa gaaaaatttt atatggaaca agagctttta gggataggtg tcagcaaaca
    51241 tccactacaa gctattgcaa gtaaggctat ttacccgatt accccaatcg gaaatttgtc
    51301 agaaaatagc tatgctatta tcttggttga agttcagaaa ataaaagtga ttcgtaccaa
    51361 aaagggtgaa aatatggcct tcttacaggc agatgatagt aagaaaaaat tggatgtcac
    51421 tctcttttca gacttatatc gtcaggttgg acaggaaata aaagagggag ccttctacta
    51481 tgtaaaagga aaaatacaat cacgtgatgg ccgtctgcaa atgattgcac aagaaataag
    51541 agaagcagtt gctgaacgct tttggataca ggtgaaaaat catgaatcgg atcaagaaat
    51601 ttcacgcatt ttagaacaat ttaaaggccc aatcccagtc atcatccggt atgaagagga
    51661 acagaaaacc atcgtttctc cccatcattt tgtagctaaa tccaatgaat tagaggagaa
    51721 attgaatgaa atcgttatga aaacgattta tcgctaaaaa tacggaaaat agaagaattt
    51781 taaaatcaaa tgtgatataa tcaagaagaa tgttaaaaga aaaaggagca taaaccaata
    51841 tgaaacgtat tgctgttttg actagtggcg gagacgcacc tggtatgaac gctgccatcc
    51901 gtgcagttgt tcgtcaagca atttcagaag gaatggaagt gtttggtatc tatgacggat
    51961 atgctggtat ggttgccggt gaaattcatc ccctagatgc agcttcagta ggggacatca
    52021 tttctcgtgg tggtactttt cttcactcag ctcgttaccc agagttcgct caacttgaag
    52081 ggcaacttaa agggattgag caattgaaaa aacacggaat tgaaggtgta gttgttatcg
    52141 gtggtgacgg atcttaccac ggcgctatgc gtttgactga acatggcttc ccagctattg
    52201 gtcttccagg tacaatcgat aacgatatcg ttggtactga ctttacaatc ggttttgaca
    52261 cagcggttac tactgccatg gacgctatcg ataagattcg tgatacatca tcaagtcacc
    52321 gtcgtacttt tgtaatcgaa gttatgggac gtaacgctgg tgatatcgct ctttgggctg
    52381 gtattgcaac tggtgctgat gaaatcatca tccctgaagc aggcttcaag atggaagata
    52441 tcgtagcaag catcaaagct ggttatgaat gtggtaaaaa acacaatatc atcgtcttag
    52501 ctgaaggtgt gatgtcagcg gatgaatttg gtcaaaaact taaagaagct ggagatacaa
    52561 gcgaccttcg tgtaacagaa cttggacata ttcaacgtgg tggttctcca actgcgcgtg
    52621 accgtgtttt ggcgtcacgt atgggtgcac atgctgttaa acttcttaaa gaaggtatcg
    52681 gtggtgttgc ggttggtatt cgtaacgaaa aaatggttga aaatccaatt cttggtactg
    52741 cagaagaagg ggcattgttt agccttactg cagaaggtaa gattgtggtt aacaacccac
    52801 acaaagccga tattgagcta tctagcttga ataagagctt gtcataattt acaatttagt
    52861 taataagacc aaaaaggtca tatatataaa ggagtcacaa aaatcatgaa caaacgtgta
    52921 aaaatcgttg caactttggg tcctgcggta gaaatccgtg gtggtaaaaa attcggtgag
    52981 gacggatact ggggtgaaaa acttgatgtt gaagcttcag ctaaaaacat tgctaaattg
    53041 attgaagctg gtgctaacac attccgattc aacttctcac acggcgacca ccaagaacaa
    53101 ggtgagcgta tggcaactgt taaacttgcg gaaaaaattg caggtaaaaa agttggtttc
    53161 cttcttgata caaaaggacc tgaaatccgt acagaattgt tcgaaggtga agctaaagaa
    53221 tattcataca aaactggtga aaaaattcgt gttgcaacta aacaaggaat caaatcaact
    53281 cgtgaagtga ttgcgttgaa cgttgctggt gctcttggta tctatgatga tgttgaagtt
    53341 ggtcgtcaag ttttggttga cgatggtaaa cttggtcttc gtgtggttgc taaagatgat
    53401 gcaactcgtg aatttgaagt tgaagttgaa aacgatggta tcatcgctaa acaaaaaggt
    53461 gtgaacatcc ctaacactaa aattcctttc ccagctcttg ctgaacgcga taacgacgat
    53521 atccgtttcg gtcttgaaca aggtatcaac ttcatcgcaa tttcattcgt acgtactgca
    53581 aaagatgtga acgaagttcg tgcaatctgt gaagaaactg gaaacggaca tgttcaattg
    53641 ttcgctaaaa tcgaaaacca acaaggtatc gataacttag acgaaatcat cgaagcagct
    53701 gatggtatta tgattgctcg tggtgatatg ggtatcgaag taccgttcga aatggttcca
    53761 gtttatcaaa aaatgattat caagaaagtc aatgctgcag gtaaagttgt tatcactgca
    53821 acaaacatgc ttgaaacaat gactgaaaaa ccacgtgcaa ctcgttcaga agtatcagac
    53881 gtattcaacg ctgttatcga cggaactgac gctacaatgc tgtcaggcga gtctgcaaac
    53941 ggtaaatacc cactcgagtc agtaactaca atggctacaa tcgacaagaa cgctcaagct
    54001 cttcttaatg aatacggacg tcttgattca gattcatttg agcgtaactc taagacagaa
    54061 gtaatggctt ctgctgttaa agatgctact aactcaatgg atatcaaatt ggttgtaact
    54121 cttactaaga caggtcatac tgcacgtttg atttctaaat accgtccaaa tgctgacatc
    54181 ttagcattga catttgacga attgacagaa cgtggcttga tgttgaactg gggtgttatc
    54241 ccaatgttga cagatgctcc atcttcaact gacgatatgt tcgaaatcgc tgaacgtaaa
    54301 gcggtagaag caggtctcgt tgagtcaggc gatgatatcg ttatcgttgc tggtgtgcca
    54361 gtaggagaag ctgttcgcac aaacacaatg cgtatccgca cagtacgtta agaaaaatat
    54421 aaaaacctat catatccagc tttatagcct gtatgatggg ctcttttttt gtccaggggg
    54481 caaaaagggg gcaaaacttt cataatggat tgatactctt cgaaaatctc ttcaaaccac
    54541 gtcagcgtcg ccttaccgta ctcaagtaca gcttgcggct agcttcctag tttgctcttt
    54601 gattttcatt gagtatgaaa taagatatgc acaaattgat tagaaagtca aatgaatttc
    54661 tacaaatgtt ttagcaatcg caatctactt gtctagattc gatctgatat attttcgatt
    54721 taatgatatg gtatttaaaa cctccaaagt agcttgctcc attcttttac ttacgtgagt
    54781 gtagatgtta tttactgttt tagcgttttt gtgttccact ctaaccatta tagcattctt
    54841 ctcagctagt gtactaagga gtgtgtgcct gaaaatatgg gaactaaggg gctggtttat
    54901 cggtttctct agtttagtat ttgccttttg caaagtgatc ttaaatgcct ttctctaaat
    54961 ttacatatca ctattgttta acaaaatcta atctacttta ggtcacttat tcttttttgc
    55021 aatgtagaat gaactttttc aaagtttttc gaatctttta aaatctgttt gttttatatc
    55081 gccattctcc cccctttttt aattctccct atatagcctg acaactttcc cgatggtaca
    55141 aatatggttg ctttcgtcta ggtggatgtc ggggtattcg ggattgagtt tttttgaggt
    55201 agccttggcg gagtttcttg acatagttag cgccgtctac ttggaagatg ccgatggtat
    55261 tatagtcaat ctgtggggta ttcttgataa ataggtagtc gctgtttctt atctttggct
    55321 ccatggactt gctgacgaca taagcgattg ggtcgtagtc gtctgggata atggaaactc
    55381 catatctaaa tcgttgtcct gcatcgagcg gctacctgca gagataaact acctaacaag
    55441 agagtaagta gtctgtctgt agtcgtccag tctgatgatt tttacgatac ttcgtttttc
    55501 tgatcataca gttgcctctc ggcataggtc agaactttac cttgtctggg tggtgcccgt
    55561 tggtcgtaga tagattggat atcgctagga gaatcctttt gaactggagg aaagagggca
    55621 tcaatcaagc tactgaatac tttaactaag tcaaatatag tatttttctt agtagaccta
    55681 accctttttt cataatttct aatggtgttt ttacttatac ctatcttagt acccaattct
    55741 tattgagtcc aaccattact agtctatatt gttttatagt tgattgagtt tggaatagta
    55801 cgctgtagct gctaaaacat ttctaggaat taatttgcct ttcctaatag agttgttcat
    55861 atcttatttc aatctatgat gtttttcacc tctaacaatc gcaatctctt ctttatccat
    55921 gaatgaaaac gttttctatt tttgtaagta aagcatcaca cgaaattcac gaaaatgaaa
    55981 acctttgttg tgttttcgta aaaaatttgt tgacagagca cgaaacgcct actataatta
    56041 agtcaagctt aaggaaataa caaaaaaaca aatcggaggg aaagacgatg aacacattaa
    56101 atgagaaagt aatcaatatc tgtaaagcag tagttaaaga aactttaatc caagacattt
    56161 aggagaaaga aatgaagaaa tcaagaaaat tagccacatt aggaatctgt tcagccttgt
    56221 ttttaggctt ggctgcttgt caacaacaac atgctacttc tgaggggacg aatcaaaggc
    56281 aaagcagttc agcgaaagtt ccatggaaag cttcatacac caacctaaac aaccaggtaa
    56341 gtacagaaga ggtcaaatct ctcttatcag ctcacttgga tccaaatagt gttgatacat
    56401 tttttaatct cgttaatgac tataatacca ttgtcggctc aactggctta tcaggagatt
    56461 tcacttcctt tactcacacc gaatacgatg ttgagaaaat cagtcatctc tggaatcaaa
    56521 agaagggcga ttttgttggg accaactgcc gtatcaatag ttattgtctt ttgaaaaatt
    56581 cagtcaccat tccaaagctt gaaaagaatg accagttgct tttcctagat aatgatgcga
    56641 ttgataaagg aaaggtcttt gattcacaag ataaggaaga gtttgatatt ctattttcga
    56701 gagttccaac tgagtcaact acagatgtca aggttcacgc tgaaaagatg gaagcattct
    56761 tctcacaatt tcaattcaat gaaaaagctc gaatgctgtc tgtagtcttg cacgacaatt
    56821 tggatggcga gtatctgttt gtaggccacg ttggggtctt agtacctgct gatgacggtt
    56881 tcttatttgt agagaaattg actttcgaag agccctacca agcgattaaa tttgctagta
    56941 aggaagattg ctacaagtat ttgggcacca agtatgcgga ttatacaggc gagggactgg
    57001 ctaagccttt tatcatggat aatgataagt gggttaaact ttaatagtgt tatgatatga
    57061 cagtaatctt aggattttta tttctatttt tgataagttg gtgggttatt tcaatcgtta
    57121 atagccagaa accacgcaaa aatgaaacat ttattggcta tgtccaaaga tacgatattg
    57181 atgggaatgg ctatcaatca ttaccgtgtc ctcagaactg agaggagttc ttgaaatcgt
    57241 aacaccactt tgaacaagag ttacttaaac ccattggctc cgacggatta agttgctttc
    57301 gtgaa
//
LOCUS       DBMVGT010000005        52458 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.005, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000005 DBMVGT010000000
VERSION     DBMVGT010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 52458)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 52458)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..52458
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.005"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..509)
                     /locus_tag="AC0DU4_000339"
                     /pseudo
     CDS             complement(1..509)
                     /locus_tag="AC0DU4_000339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511369.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
     gene            complement(883..1032)
                     /locus_tag="AC0DU4_000340"
     CDS             complement(883..1032)
                     /locus_tag="AC0DU4_000340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope"
                     /protein_id="HIN4236360.1"
                     /translation="MEKFNFKNNIGQENKLLQIEIYKFTNFCKLQNYTSVNIFSKDIF
                     EAIVN"
     gene            997..1116
                     /locus_tag="AC0DU4_000341"
     CDS             997..1116
                     /locus_tag="AC0DU4_000341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase"
                     /protein_id="HIN4236361.1"
                     /translation="MPDIVFEIEFFHSDSLIFFYTSDDKSNSQKSQEDFSKNK"
     gene            complement(1212..2558)
                     /gene="glnA"
                     /locus_tag="AC0DU4_000342"
     CDS             complement(1212..2558)
                     /gene="glnA"
                     /locus_tag="AC0DU4_000342"
                     /EC_number="6.3.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004356 - glutamine synthetase activity
                     [Evidence IEA];
                     GO_process: GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="HIN4236362.1"
                     /translation="MPITAADIRREVKEKNVTFIRLMFSDILGTMKNVEIPATDEQLD
                     KVLSNKVMFDGSSIEGFVRINESDMYLYPDLDTWTVFPWGDENGSVAGLICDVYTTEG
                     EPFAGDPRGNLKRALRHMEEVGFKSFNLGPEPEFFLFKLDENGDPTLEVNDKGGYFDL
                     APTDLADNTRREIVNVLTKMGFEVEASHHEVAVGQHEIDFKYDEVLRACDKIQIFKLV
                     VKTIARKHGLYATFMAKPKFGIAGSGMHCNMSLFDAEGNNAFFDPNDPKGMQLSETAY
                     HFLGGLIKHAYNYTVIMNPTVNSYKRLVPGYEAPVYIAWAGRNRSPLVRVPASRGMGT
                     RLELRSVDPMANPYIAMAVLLEVGLYGIENKIEAPAPIEENIYIMTAEERKEAGITDL
                     PSTLHNALKALTEDEVVKAALGDHIYTSFLEAKRIEWASYATFVSQWEIDNYLDLY"
     gene            complement(2595..2951)
                     /gene="glnR"
                     /locus_tag="AC0DU4_000343"
     CDS             complement(2595..2951)
                     /gene="glnR"
                     /locus_tag="AC0DU4_000343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000659547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor GlnR"
                     /protein_id="HIN4236363.1"
                     /translation="MKEKEFRRNMAVFPIGSVMKLTDLSARQIRYYEDQELIKPDRNE
                     GNRRMYSLNDMDRLLEIKDYISEGYNIAAIKKKYAEREAKSKKAVSQTEVRRALHNEL
                     LQQGRFASVQSPFGRG"
     gene            complement(3028..3555)
                     /locus_tag="AC0DU4_000344"
     CDS             complement(3028..3555)
                     /locus_tag="AC0DU4_000344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FUSC family protein"
                     /protein_id="HIN4236364.1"
                     /translation="MSYFKKYKFDKSQFKLGMRTFKTGIAVFLVLLIFGFFGWKGLQI
                     GALTAVFSLRESFDESVHFGTSRILGNSIGGLYALVFFLLNTFFHEAFWVTLVVVPIC
                     TMLTIMTNVAMNNKAGVIGGVAAMLIITLSIPSGETISYVFVRVSETFMGVFVAIIVN
                     YDIDRIRLFLEKKEK"
     gene            complement(3691..4887)
                     /locus_tag="AC0DU4_000345"
     CDS             complement(3691..4887)
                     /locus_tag="AC0DU4_000345"
                     /EC_number="2.7.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004618 - phosphoglycerate kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HIN4236365.1"
                     /translation="MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTI
                     KYIIEQGGRAILFSHLGRVKEEADKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEA
                     AINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHA
                     SNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEK
                     ADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAF
                     AGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAG
                     TIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGL
                     AALTEK"
     gene            complement(4977..9887)
                     /locus_tag="AC0DU4_000346"
     CDS             complement(4977..9887)
                     /locus_tag="AC0DU4_000346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000795197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0033925 - mannosyl-glycoprotein
                     endo-beta-N-acetylglucosaminidase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endo-beta-N-acetylglucosaminidase"
                     /protein_id="HIN4236366.1"
                     /translation="MKNPFFERRCRYSIRKLSVGACSLMIGAVLFAGPALAEETAVPE
                     NSGANTELVSGESEHSTNEADKQNEGEHARENKLEKAEAASAAKPEEKAGEVVAETPS
                     AEAKPKSDKETEAKPEATNQGDESKPAAEANKTEKEVQPDVPKNTEKTLKPKEIKFNS
                     WEELLKWEPGAREDDAINRGSVVLASRRTGHLVNEKASKEAKVQALSNTNSKAKDHAS
                     VGGEEFKAYAFDYWQYLDSMVFWEGLVPTPDVIDAGHRNGVPVYGTLFFNWSNSIADQ
                     ERFAEALKQDADGSFPIARKLVDMAKYYGYDGYFINQETTGDLVKPLGEKMRQFMLYS
                     KEYAAKVNHPIKYSWYDAMTYNYGRYHQDGLGEYNYQFMQPEGDKVPADNFFANFNWD
                     KAKNDYTIATANWIGRNPYDVFAGLELQQGGSYKTKVKWNDILDENGKLRLSLGLFAP
                     DTITSLGKTGEDYHKNEDIFFTGYQGDPTGQKPGDKDWYGIANLVADRTPAVGNTFTT
                     SFNTGHGKKWFVDGKVSKDSEWNYRSVSGVLPTWRWWQTSTGEKLRAEYDFTDAYNGG
                     NSLKFSGDVAGKTDQDVRLYSTKLEVTEKTKLRVAHKGGKGSKVYMAFSTTPDYKFDD
                     ADAWKELTLSDNWTNEEFDLSSLAGKTIYAVKLFFEHEGAVKDYQFNLGQLTISDNHQ
                     EPQSPTSFSVVKQSLKNAQEAEAVVQFKGNKDADFYEVYEKDGDSWKLLTGSSSTTIY
                     LPKVSRSASAQGTTQELKVVAVGKNGVRSEAATTTFEWGMTVQDTSLPRPLAENIVPG
                     ATVIGSTFPDTEGGEGIEGMLNGTITSLSDKWSSAQLSGSVDIRLTKPRTVVRWVMDH
                     AGAGGESVNDGLMNTKDFDLYYKDADGKWKLAKEVRGNKAHVTDITLDKPITAQDWRL
                     NVVTSDNGTPWKAIRIYNWKMYEKLDTESVNIPMAKAAARSLGNNKVQVGFADVPAGA
                     TITVYDNPNSQTPLATLKSEVGGDLASAPLDLTNQSGLLYYRTQLPGKEISNVLAVSV
                     PKDDRRIKSVSLETGPKKTSYAEGEDLDLRGGVLRVQYEGGTEDELIRLTHAGVSVSG
                     FDTHHKGEQNLTLQYLGQPVNANLSVTVTGQDEASPKTILGIEVSQEPKKDYLVGDSL
                     DLSEGRFAVAYSNDTMEEHSFTDEGVEISGYDAQKTGRQTLTLRYQGHEVNFDVLVSP
                     KAALNDEYLKQKLAEVEAAKNKVVYNFASPEVKEAFLKAIEAAEQVLKDHETSTQDQV
                     NDRLNKLTEAHKALNGQEKFKEEKTELDRLTGEVQELLAAKPNHPSGSALAPLLEKNK
                     ALVEKVDLSPEELATAKQSLKDLVALLKEDKPAVFSDSKTGVEVHFSNKEKTVIKGLK
                     VERVQASAEEKKYFAGEDAHVFEIEGLDEKGQDVDLSYASIVKIPIEKDKKVKKVFFL
                     PEGKEAVELAFEQTDSHVIFTAPHFTHYAFVYESAEKPQPAKPAPQNKVLPKPTYQPA
                     SDQQKAPKLEVQEEKVAFHRQEHENTEMLVGEQRVIIQGRDGLLRHVFEVDENGQRRL
                     RSTEVIQEAIPEIVEIGTKVKTVPAVVATQEKPAQNTAVKSEEASKQLPNTGTADANE
                     ALIAGLASLGLASLALTLRRKREDKD"
     gene            10180..11823
                     /locus_tag="AC0DU4_000347"
     CDS             10180..11823
                     /locus_tag="AC0DU4_000347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0005436 - sodium:phosphate symporter
                     activity [Evidence IEA];
                     GO_process: GO:0044341 - sodium-dependent phosphate
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HIN4236367.1"
                     /translation="MSINWQEILFHFLGGLGLFLYSIKTMGDGLQQAAGDRLRFYIDK
                     YTSNPFFGVLVGIGMTALIQSSSGVTVITVGLVSAGLLTLRQAIGIVMGANIGTTVTS
                     FLIGFKLGNYALPMLFIGAVCLFFTKNRTVNNIGRILFGVGGIFFALNLMSGAMAPLK
                     DLQVFKDYMIELSKNPVLGVFVGTGLTLLIQASSATIGILQNLYAGNLIDLQGALPVL
                     FGDNIGTTITAIIASLGANIAAKRVAGAHVAFNVIGTVVCVIFLVPFTVLIHWFEATL
                     NLAPEMTIAFAHGTFNITNTIVQFPFIGALAYFVTKIIPGEDEVVKYEPLYLDEHFIK
                     QAPSIALGNAKKELLHLGNYAAKAFDLSYKYIIDLDEKVAEKVAEKGHKTEEAINTID
                     EQLTRYLIALSSEALSQKESEVLTNILDSSRDLERIGDHTEALLNLTDYLQRKNVEFS
                     DAALKELEEVYRQTSDFIKDALDSVENNDIEKARSLVERHEAINKIERVLRKTHIKRL
                     NKGECSTQAGVNFIDIISHYTRVSDHAMNLAEKVFAEQI"
     gene            complement(12382..13989)
                     /locus_tag="AC0DU4_000348"
     CDS             complement(12382..13989)
                     /locus_tag="AC0DU4_000348"
                     /EC_number="6.3.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003883 - CTP synthase activity [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0006241 - CTP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CTP synthase"
                     /protein_id="HIN4236368.1"
                     /translation="MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPY
                     INIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRK
                     ERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALR
                     QMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPA
                     GQGIKNKLAQFCDVAPEAVIESLDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAAAMT
                     EWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYVNDAEVKINWVNAND
                     VTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEF
                     ARHVLGLEGANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAA
                     YHNQEVVQRRHRHRYEFNNAFREQFEAAGFVFSGVSPDNRLVEIVEIPENKFFVACQY
                     HPELSSRPNRPEELYTAFVTAAVENSN"
     gene            complement(14379..14966)
                     /gene="rpoE"
                     /locus_tag="AC0DU4_000349"
     CDS             complement(14379..14966)
                     /gene="rpoE"
                     /locus_tag="AC0DU4_000349"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003899 - DNA-directed RNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit delta"
                     /protein_id="HIN4236369.1"
                     /translation="MELEVFAGQEKSELSMIEVARAILELRGRDHEMHFSDLVNEIQN
                     YLGTSNSDIREALPLFYTELNFDGSFISLGDNKWGLRSWYGVDEIDEEIIALEENDDD
                     EVAPKAKKKRVNAFMDGDSDAIDYNADDPEDEDAYEADPALSYDDENPDDEKNEVEAY
                     DAEINEIAPDDLGEDVDLNEDDDEFSDDDAETSEE"
     gene            complement(15094..15405)
                     /locus_tag="AC0DU4_000350"
                     /pseudo
     CDS             complement(15094..15405)
                     /locus_tag="AC0DU4_000350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333655.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase family protein"
     gene            complement(15411..15715)
                     /locus_tag="AC0DU4_000351"
                     /pseudo
     CDS             complement(15411..15715)
                     /locus_tag="AC0DU4_000351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867286.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(15743..16393)
                     /locus_tag="AC0DU4_000352"
     CDS             complement(15743..16393)
                     /locus_tag="AC0DU4_000352"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466738.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016791 - phosphatase activity [Evidence
                     IEA];
                     GO_process: GO:0006629 - lipid metabolic process [Evidence
                     IEA];
                     GO_process: GO:1901137 - carbohydrate derivative
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HIN4236370.1"
                     /translation="MKDKQTFLMKGSFALLLFVILGYMVKFYPETLVGFDQSIQTAIR
                     GDLPDYLTILFRSLTHLIDIPVIITWVVIIAFVFYRKRWKIESFFMLGNLALAGLLIV
                     TFKNIYQRPRPAILHLVEEKGFSFPSGHSLAVTLMVGTLIVILSQRIKDQVWRKIVQI
                     VLGLYLVSVLVSRVYLGVHYPSDVLASFCVGLGVLFIEFPFYDKLRFQWRFKGKQK"
     gene            complement(16383..16946)
                     /locus_tag="AC0DU4_000353"
     CDS             complement(16383..16946)
                     /locus_tag="AC0DU4_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HIN4236371.1"
                     /translation="MTNTRRLSTIAILSAISFVLMYFDFPLLPAASFLKIEFSILPVL
                     VGLVVMDLPAALGVLLLRSLLKLLLNSQGVNTYIGLPMNIVALGVFVIVFALIWKKER
                     TTLRFLLGSLAGTVGLTLAMLVLNYVYAVPLYAKFANFDIGKILGLSNYLMTMVLPFN
                     LIEGVIFSVSFWLLYVLLKPTLKHYER"
     regulatory      complement(17111..17345)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            complement(17399..17902)
                     /locus_tag="AC0DU4_000354"
     CDS             complement(17399..17902)
                     /locus_tag="AC0DU4_000354"
                     /EC_number="2.1.1.207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0141098 - tRNA
                     (cytidine(34)-2'-O)-methyltransferase activity [Evidence
                     IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0001510 - RNA methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (cytidine(34)-2'-O)-methyltransferase"
                     /protein_id="HIN4236372.1"
                     /translation="MTNHIVLFEPQIPQNTGNIARTCAATNSPLHIIKPMGFPIDDRK
                     MKRAGLDYWDKLEIYFYESLEDFISQMKGKLYLISKFAEKVYSEVDLSTDEDHYFLFG
                     REDKGLPEDFMREHPEKALRIPMNDEHVRSLNVSNTVCMIVYEALRQQNFAGLELVHT
                     YEVDKLK"
     gene            complement(18095..18925)
                     /locus_tag="AC0DU4_000355"
     CDS             complement(18095..18925)
                     /locus_tag="AC0DU4_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     component T family protein"
                     /protein_id="HIN4236373.1"
                     /translation="MQAKLIGYQHRDTVIHRLSGAGKLLFFILVSLAAMISYDTRMLL
                     LIAIFSVFLLYLSEIRFKDVSFVAVFATVFAVLNVLMVYLFSPEYGVGLYGERSVIWQ
                     GIGVYTLTSQELFYLLNLAIKYLCTIPLAIIFLMTTHPSQFASSLNQIGVPYKIAYSV
                     SLTLRYIPDLQEEFFTIKMSQEARGMELSKKASLMQRIKGNLLIITPLIFSSLERIDT
                     IATAMELRRFGKEKKRTWYSYQALKKGDYITLLLATLFLVVSLLLILQNQGRFYNPWK
                     "
     gene            complement(18910..20592)
                     /locus_tag="AC0DU4_000356"
     CDS             complement(18910..20592)
                     /locus_tag="AC0DU4_000356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000656554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236374.1"
                     /translation="MKEAIIEWKDFSFRYETQQEPTLQGIDLTIYKGEKVLIVGPSGS
                     GKSTLGQCLNGIIPNIYKGQTYGEFLIKGQTAFDMSIYDKSHLVSTVLQDTDGQFIGL
                     SVAEDLAFALENDVTALDEMKGRVYKWAEKLDLLPLLDQRPQDLSGGQKQRVSLAGVL
                     IDESPILLFDEPLANLDPKSGQDIIELIDQIHKEEGTTTLIIEHRLEDVLHCPVDRIV
                     LINDGRILFNGSPDQLLATDLLTQNGIREPLYLTTLRQLGVDLVKEEQLANLDNLSIS
                     KGQVQLQNELAKETPALQSLFRLEEVSFSYDDRPILKSLHLDIKKGEKIAIVGKNGAG
                     KSTLAKAISSFIQTEGRYLWEKQDIKGDSVAERAERVGYVLQNPNQMISTNMIFDEVA
                     LGLRLRGVDEKEIETRVYETLKICGLYEFRNWPISALSFGQKKRVTIASILVLGAEII
                     LLDEPTAGQDQKNYTEIMEFLEELHQKGHTIVMITHDMQLMLDYSDRVLVMVDGELIA
                     DTVPASLLSDPELLVKANLKETSIFNLAKKLDVDPLDLTAFYKERREGCKLN"
     gene            complement(20703..20951)
                     /locus_tag="AC0DU4_000357"
     CDS             complement(20703..20951)
                     /locus_tag="AC0DU4_000357"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236375.1"
                     /translation="MKIKEQTRKLAAGCSKQCFEIVDRTDEVSSKHGFEVVDETDEVS
                     NHTYGKAKLTWFEEIFEEYKMMGKAGQLVFFDVYRLVR"
     gene            complement(20958..21506)
                     /locus_tag="AC0DU4_000358"
     CDS             complement(20958..21506)
                     /locus_tag="AC0DU4_000358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ECF-type riboflavin transporter
                     substrate-binding protein"
                     /protein_id="HIN4236376.1"
                     /translation="MEIKFTIKQVVAVGIGAALFVVIGMINIPTPVPNTSIQLQYAVQ
                     ALLSIIFGPIIGLLVGLIGHAIKDSLAGYGLWWTWIIASGLFGLVVGLFRKYVRVING
                     VFDWKDILIFNLIQLLANALVWGVLAPLGDVVIYQEAAEKVFAQGIVAGIANGVSVAI
                     AGTLLLLAYAGTQTRAGSLKKD"
     gene            complement(21521..22369)
                     /locus_tag="AC0DU4_000359"
     CDS             complement(21521..22369)
                     /locus_tag="AC0DU4_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SAM hydrolase/SAM-dependent halogenase family
                     protein"
                     /protein_id="HIN4236377.1"
                     /translation="MNNNLLVLQSDFGLVDGAVSAMIGVALEESPTLKIHHLTHDITP
                     YNIFEGSYRLFQTVDYWPEGTTFVSVVDPGVGSKRKSVVAKTAKNQYIVTPDNGTLSF
                     IKKHVGIVAIREISEVANRRQNTEHSYTFHGRDVYAYTGAKLASGHITFEEVGPELSV
                     EQIVELPVVATIIEDHLVKGAIDILDVRFGSLWTSITREEFYKLEPEFGDRFEVTIYH
                     ADMLVYQNQVVYGKSFADVRIGQPILYINSLYRLGLAINQGSFAKAYNVGVGSSWTIE
                     IKKIEG"
     gene            22557..23906
                     /gene="trkA"
                     /locus_tag="AC0DU4_000360"
     CDS             22557..23906
                     /gene="trkA"
                     /locus_tag="AC0DU4_000360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Trk system potassium transporter TrkA"
                     /protein_id="HIN4236378.1"
                     /translation="MKIILVGGGKVGFALCRSLVAEKHDVLLIEQDEAVLNHIVSRFD
                     IIGILGNGADFAILEQASVQDCDIFIALTEHDEVNMIAAVLAKKMGAKETIVRVRNPE
                     YSNSYFKEKNILGFSLIVNPELLAARAIANIIDFPNALSVERFAGGRVSLMEFVVKST
                     SGLCQMPISDFRKKFGNVIVCAIERDHQIIIPSGDMTVQDKDRIFVTGNRVDMILFHN
                     YFKSRAVKSLLIVGAGRIAYYLLGILKDSRIETKVIEINPEIASFFSEKFPNLYIVQG
                     DGTAKDILLEESAQHYDAVATLTGVDEENLITSMFLDRVGVQKNITKVNRTSLLEIIN
                     APDFSSIITPKSIAVDTIMHFIRGRVNAQYSDLQAMHHLANGQIETLQFHIKEANKMT
                     AKPLSQLKLKKGVLIAAIIRKGKTIFPTGEDMLEVGDKLLVTTLLPNITKIYDLIAR"
     gene            23910..25349
                     /locus_tag="AC0DU4_000361"
     CDS             23910..25349
                     /locus_tag="AC0DU4_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0015079 - potassium ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HIN4236379.1"
                     /translation="MNKSMIRYLLSKLLLIEAVLLLVPVAIAVYYRESSQVFTALFST
                     IGILVLLGGSGSLQKPKNQRIYAKEGVLIVALCWILWSFFGGLPFVFSGQIPSVIDAF
                     FEISSGFTTTGASILNDVSVLSRSLLFWRSFTHLIGGMGVLVFALAIMDNAKNSHLEV
                     MKAEVPGPVFGKVVSKLKNTAQILYLLYLALFSLFVIIYYLAGMPLYDSFVIAMGTAG
                     TGGFTVYNDGIAHYGSSLITYLVSIGVLVFGVNFNLYYYLMLRRIKAFFGDEELRAYL
                     VIVLVSTGLISLNTLYLYPGFSKSFEMTFFQVSNIITTTGFGYGDITNWPLFSQFILL
                     FLMAIGGSAGSTAGGLKIIRGLILSKIAKNQILSILSPHRVLTLHVNQTVIDKDTQHK
                     ILKYFVIYAMILLALIFIVSLDSNDFLVVTSAVFSCFNNIGPILGTTSSFSIFSPISK
                     ILLSFAMIAGRLEIYPILLLFMKRTWSKR"
     gene            complement(25474..27153)
                     /locus_tag="AC0DU4_000362"
     CDS             complement(25474..27153)
                     /locus_tag="AC0DU4_000362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose transporter subunit IIBC"
                     /protein_id="HIN4236380.1"
                     /translation="MDKLVAAIEKQQGKFEKISTNNYMMAIKDGFIATMPLIMFSSFL
                     MIIIMIPKNFGVELPSPAIAWMRKVYMLTMGVLGVIVSGTVAKSLAGNVNRKMPPGKV
                     INDTSAMLAAICGYLVLTVTLVVDEKTGSTSLSTNYLGSQGLITSFVSAFITVNVYRF
                     CIKRDITIHLPKEVPGAISQAFRDIFPFSFVLLISGLLDIVSRFSLDVPFAQVFQQLL
                     TPIFKGAESYPAMMLIWFMCALLWFVGIHGPSIVLPAVTALQLSNMEENAQLLANGQF
                     PYHSLTPNFGNYIAAIGGTGATFVVPFILIFFMRSKQLKSVGKATITPVLFAVNEPLL
                     FGMPVILNPYLFVPFLMTPPVNVFLGKVFIDFFGMNGFYIQLPWAFPGPLGLLIGTNF
                     QSISFVFLSLILVVDILIYLPFCRAYDRQLLMKEDVASSNDIILEEETSEIMPGELDE
                     IKSKELKVLVLCAGSGTSAQLANAINEGAQLAEVRVIANSGAYGAHYDIMGVYDLIIL
                     APQVRSYYREMKVDAERLGIQIVATRGMEYIHLTKNPSKALQFVLEHYQAV"
     gene            complement(27223..28635)
                     /gene="lacG"
                     /locus_tag="AC0DU4_000363"
     CDS             complement(27223..28635)
                     /gene="lacG"
                     /locus_tag="AC0DU4_000363"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033920 - 6-phospho-beta-galactosidase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HIN4236381.1"
                     /translation="MENLQVKALPKEFLLGAATAAYQVEGATRVDGKGINMWDVYLQE
                     NSPFLPDPASDFYYRYEEDIALAAEHGLQALRLSISWVRIFPDIDGEPNILAVRYYHR
                     VFQSCLKYNVIPFVSLHHFDSPQKMLETGDWLNRENIDRFIRYARFCFQEFTEVKHWF
                     TINELMSLAAGQYIGGQFPPNHHFQLSEAIQANHNMLLAHALAVLEFHQLGIEGKVGC
                     IHALKPGYPIDGQKENILAAKRYDVYNNKFLLDGTFLGYYSDDTLFHLNQILEANNSS
                     FIIEDGDLEIMKRAAPLNTMFGMNYYRSEFIREYKGENRQEFNSTGIKGQSSFKLNAL
                     GEFVKKPGIPTTDWDWNIYPQGLFDMLLRIKEEYPQHPVIYLTENGTALKEVKPEGEN
                     DIIDDSKRIRYIEQHLHKVLEARDRGVNIQGYFIWSLQDQFSWANGYNKRYGLFFVDY
                     ETQKRYIKKSALWVKGLKRN"
     gene            complement(28645..28989)
                     /locus_tag="AC0DU4_000364"
     CDS             complement(28645..28989)
                     /locus_tag="AC0DU4_000364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000836781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HIN4236382.1"
                     /translation="MKSKEEINMLGFTIVAYAGDARSDLMDALAFARDGYFEQARELV
                     ESANDSIVSAHREQTNLLAEEAYGDNFEVSFIMIHGQDTLMTTMLLYDQVKFFIDEYE
                     RIRKIEEHIGLQ"
     gene            complement(29157..31043)
                     /locus_tag="AC0DU4_000365"
     CDS             complement(29157..31043)
                     /locus_tag="AC0DU4_000365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000236922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4838 domain-containing protein"
                     /protein_id="HIN4236383.1"
                     /translation="MVIRVFDKQKNTYSSFALEELSYYINRVFKTDIELVEEKEADIF
                     VGLVNKEDRRDHVLISLDKGKGRIESNTIVGLLIGIYRMFHEFGVVYTRPGRGHDFVP
                     ELRFEDFLDKQLSIDETASYYHRGVCIEGADSFENILDFIDWLPKIGMNSFFIQFENP
                     YSFLKRWYEHEFNPYLNKEQFSNELVQELSDRLDKELQKRGLIHHRVGHGWTGEVLGY
                     SSKFGWESGLSISEEKKPYVAEINGKRELFNTAPILTSLDFSNPDVADKMVEIIKDYA
                     KKRPDVNYLHVWLSDARNNICECENCRQELVSDQYIRILNQLDRALTSEGLDTKICFL
                     LYHELLWAPQKEKLDNPERFTMMFAPITRTFEMSYADVDFDNSIPTPKPYLRNKIILP
                     NSLEENLSYLFEWQKAFKGDSFVYDYPLGRAHYGDLGYMKISQTIYRDVSYLSNLHLN
                     GYISCQELRAGFPHNFPNYVMGQMLWKKTRNYEELIEEYFSALYGENWQSVVEYLEKL
                     SIYSSCDYFNAIGSRQSDVLANHYYIAYNLADNFLPIIEENISKLLNSQKDEWKQLSY
                     HREYVVKMAKALYLQATGKTRQAQDEWKNVLNYIRGHELLFQSNLDVYRVIEVAKNYA
                     GFHL"
     gene            complement(31045..32367)
                     /locus_tag="AC0DU4_000366"
     CDS             complement(31045..32367)
                     /locus_tag="AC0DU4_000366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HIN4236384.1"
                     /translation="MNNILAFLETKVAPFGEKVGNQRHLKAIREGFMMAMPLILVGSL
                     FLILISWPQEAFTNWLNSVGLLSILTTMNQSTVAIISLVACFGIAYRLSEGYGTDGPS
                     AGIIALSSFVLMAPRFSSMVYDKNGEQVKQLFGGAIPFSSLNASSLFMAITIGLVTAE
                     IYRMFIQRGITIKMPSGVPDVVSKSFSALLPGFTTFVLWALVLKGLEAAGVAGGLNGL
                     LGAIVGTPLKLIAGTLPGMILCVIVNSFFWFCGVNGGQVLNAFVDPVWLQFTTENQEA
                     VAAGQTLQHIITLPFKDLFVFIGGGGATIGLAICLFLFSKSRANKTLGKLAIIPSIFN
                     INTAILFTFPTVLNPIMLIPFIATPTINALITYVSMAVGLVPYTTGVILPWTMPPIIG
                     GFLATGASWRGALLQVVLILVSVAIYYPFFKIADKRNLEKEKATVGGK"
     gene            32535..33758
                     /locus_tag="AC0DU4_000367"
     CDS             32535..33758
                     /locus_tag="AC0DU4_000367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HIN4236385.1"
                     /translation="MITKQSAFLQNRATILEFLYRNPATSRTDIVNETGLTPATTTNI
                     IKELSEQSLIYETGDEFSEFSGSGRRRKTISITDNIPYVVGGIEINVLGIFLSLCDLQ
                     GKTLFETEILNEDYPISEINSTITNMIKTAIEYVPLETKLLGFGLSIPGHYNKDSGSI
                     ITNNPIWESFNLLNVIKRFNFPFIVKNNIDCMAIGQYLFNPHNTPDNFIFLHAGLGIY
                     TSFFTKEKIGASKNPYIGEIGHTIVELNGQYCECGKKGCLQTYISDAWLIKHAQLLFK
                     NSQLTVLKSLVKTEKDIHLDTLLTAYNLGDSALRQQIDKGVNLLATSIANLLLINPAD
                     KIYINSQLLNYQPFTHEVRDKIQDQLHFVPFTRNIEIEILPYNKHRGSIGACALAIVA
                     FFIEHSNVLQDIISP"
     gene            35190..35474
                     /locus_tag="AC0DU4_000368"
     CDS             35190..35474
                     /locus_tag="AC0DU4_000368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002923859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236386.1"
                     /translation="MDWYDYMIQASKQSQFNASHWFRYLRKVIFEDYSYLTNQDVEKL
                     LDSKELTRFQKISLKYAFQEHTPTHKYVISLNKPAKLTNVQKLMEKYKHG"
     gene            35467..35715
                     /locus_tag="AC0DU4_000369"
     CDS             35467..35715
                     /locus_tag="AC0DU4_000369"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236387.1"
                     /translation="MDKMKPVFQALNKELIQENLTLTIICVDGYVLEYHGLHATQDVD
                     AFYDQNQKINEIIARVGKQFNLNIHEELWLNNHVAKQI"
     gene            35811..36029
                     /locus_tag="AC0DU4_000370"
     CDS             35811..36029
                     /locus_tag="AC0DU4_000370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236388.1"
                     /translation="MMSIREQDLQDIGAIIKYKNFHSPFDTFKYLKDMGFDTIDLSVL
                     LESFSYAYGMDWLEKFFKENQDKLREFY"
     gene            complement(36397..38721)
                     /gene="pflB"
                     /locus_tag="AC0DU4_000371"
     CDS             complement(36397..38721)
                     /gene="pflB"
                     /locus_tag="AC0DU4_000371"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008861 - formate C-acetyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HIN4236389.1"
                     /translation="MVVKTVVEAQDIFDKAWEGFKGVDWKEKASVSRFVQANYTPYDG
                     DESFLAGPTERSLHIKKIVEETKAHYEETRFPMDTRPTSIADIPAGFIDKENEVIFGI
                     QNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFRAYTSNIR
                     RARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAIKEIDEETIRLRE
                     EVNLQYQALQQVVRLGDLYGVDVRKPAMNVKEAIQWVNIAFMAVCRVINGAATSLGRV
                     PIVLDIFAERDLARGTFTESEIQEFVDDFVMKLRTVKFARTKAYDQLYSGDPTFITTS
                     MAGMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDKLPYNFRRYCMHMSHKHS
                     SIQYEGVTTMAKDGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNG
                     GYDDVHKDYKVFDIEPIRDEVLEFESVKANFEKSLDWLTDTYVDALNIIHYMTDRYNY
                     EAVQMAFLPTKQRANMGFGICGFANTVDTLSAIKYATVKPIRDEDGYIYDYETIGDYP
                     RWGEDDPRSNELAEWLIEAYTTRLRSHKLYKDAEATVSLLTITSNVAYSKQTGNSPVH
                     KGVYLNEDGSVNLSKLEFFSPGANPSNKAKGGWLQNLNSLSSLDFSYAADGISLTTQV
                     SPRALGKTRDEQVDNLVTILDGYFENGGQHVNLNVMDLNDVYEKIMSGEDVIVRISGY
                     CVNTKYLTPEQKTELTQRVFHEVLSMDDALDALS"
     gene            39069..40130
                     /gene="dinB"
                     /locus_tag="AC0DU4_000372"
     CDS             39069..40130
                     /gene="dinB"
                     /locus_tag="AC0DU4_000372"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003684 - damaged DNA binding [Evidence
                     IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase IV"
                     /protein_id="HIN4236390.1"
                     /translation="MLIFPLLNDLSRKIIHIDMDAFFAAVEIRDNPKLRGKPVIIGSD
                     PRQTGGRGVVSTCSYEARAFGVHSAMSSKEAYERCPQAVFISGNYEKYKSVGLQIRAI
                     FKRYTDLIEPMSIDEAYLDVTENKLGIKSAVKIARLIQKDIWQELHLTASAGISYNKF
                     LAKMASDYQKSHGLTVILPEQAEDFLKQMDISKFHGVGKKTVERLHQMGVFTGADLLE
                     VPEVTLIDRFGRLGYDLYRKARGIHNSPVKSNRIRKSIGKEKTYGKILCAEEDIKKEL
                     TLLSEKVALNLHQQEKAGKIVILKIRYEDFSTLTKRKSIAQKTQDASQISQIALQLYE
                     ELSEKERGVRLLGITMTGF"
     gene            complement(40277..41122)
                     /locus_tag="AC0DU4_000373"
     CDS             complement(40277..41122)
                     /locus_tag="AC0DU4_000373"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA];
                     GO_process: GO:0016311 - dephosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HIN4236391.1"
                     /translation="MYLIEILKSIFFGIVEGITEWLPISSTGHLILAEEFIQYQNQNE
                     AFMSMFNVVIQLGAILAVMVIYFNKLNPFKPTKDKQEVRKTWRLWLKVLIATLPLLGV
                     FKFDDWFDTHFHNMVSVALMLIIYGVAFIYLEKRNKARAIEPSVTELDKLPYTTAFYI
                     GLFQVLALLPGTSRSGATIVGGLLNGTSRSVVTEFTFYLGIPVMFGASALKIFKFVKA
                     GELLSFGQLFLLLVAMGVAFAVSMVAIRFLTSYVKKHDFTLFGKYRIVLGSVLLLYSF
                     VRLFV"
     gene            41377..42348
                     /locus_tag="AC0DU4_000374"
     CDS             41377..42348
                     /locus_tag="AC0DU4_000374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001826497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
                     /protein_id="HIN4236392.1"
                     /translation="MLYVGIDIAKNKHDVTALNVPGKTVLKPLTFSNNKAGFELLDLS
                     LRQLNQDCLIALKLLSDPNREQFQHDNRQVDLKILARHIHRLKKKQSDWKVQYTRCLD
                     IIFPELDKIVGKHSEYTYQLLTRYPNPQKRIEAGFDKLIEIKRLTASKIQDILSVAPR
                     SIGTTSPAREFEIIEIIKHYKRLIDKAETCVNDLMAEFNSVITTVTGIGGRLGAVILA
                     EIRNIHAFDNPAQLQAFAGLDSSIYQSGQIDLAGRMIKRGSPHLRWALIQAAKACARF
                     SPAFKAYLKTKLEQGKHYNVAIIHLAKKLIRTLFYILKKSCHLTNKK"
     gene            complement(42547..44436)
                     /locus_tag="AC0DU4_000375"
     CDS             complement(42547..44436)
                     /locus_tag="AC0DU4_000375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2207 family protein"
                     /protein_id="HIN4236393.1"
                     /translation="MKKTFFLLVLGLFCLLPLSVFAIDFKINSYQGDLYIHADNTAEF
                     RQKIVYQFEEDFKGQIVGLGRAGKMPSGFDIDPHPKVQAAKNGAELADVTSEVTEEAD
                     GYTVRVYNPGQEGDIVEVDLVWNLKNLLFLYDDIAELNWQPLTDSSESIEKFEFHVRG
                     DKGAEKLFFHTGKLFREGTIEKSNLDYTIRLDNLPAKRGVELHAYWSRTDFASARDQG
                     LKGNRLEEFNKIEDSIVREKDQSKQLVTWVLPSILSISLLLSVCFYFIYRRKTTPSVK
                     YAKNHRLYEPPMELEPMVLSEAVYSTSLEEVSPLVKGAGKFTFDQLIQATLLDVIDRG
                     NVSIISEGDAVGLRLVKEDGLSRFERDCLNLAFSGKKEATLSNLFADYKVSDSLYRRA
                     KVSDEKRIQARGLQLKSSFEEVLNQMQEGVRKRVSFWGLPDYYRPLTGLEKTLQVGMG
                     VLTILPLFIGFGLFLYSLDVHGYLYLPLPILGFLGLVLSVFYYWKLRLDNRDGVLNEA
                     GAEVYYLWTSFENMLREIARLDKAELESIVVWNRLLVYATLFGYADKVSHLMKVHQIQ
                     VENPDINLYVAYGWHSMFYHSSAQMSHYASVANTASTYSVSSGSGSSGGGFSGGGGGG
                     SIGAF"
     gene            44574..46139
                     /locus_tag="AC0DU4_000376"
     CDS             44574..46139
                     /locus_tag="AC0DU4_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HIN4236394.1"
                     /translation="MRKIYLSIFTSLLLMLGLVNVAQADEYLRIGMEAAYAPFNWTQD
                     DDSNGAVKIDGTNQYANGYDVQIAKKIAKDLGKEPLVVKTKWEGLVPALTSGKIDMII
                     AGMSPTAERKQEIAFSSSYYTSEPVLLVKKDSAYASAKSLDDFNGAKITSQQGVYLYD
                     LIAQIPGAKKETAMGDFAQMRQALEAGVIDAYVSERPEALTAEAANSKFKMIQVEPGF
                     KTGEEDTAIAIGLRKNDNRISQINASIETISKDDQVALMDRMIKEQPAEATTTEETSS
                     SFFSQVAKILSENWQQLLRGAGITLLISIVGTIIGLIIGLAIGVFRTAPLSENKAIYG
                     LQKLVGWVLNVYIEIFRGTPMIVQSMVIYYGTAQAFGINLDRTLAAIFIVSINTGAYM
                     TEIVRGGILAVDKGQFEAATALGMTHNQTMRKIVLPQVVRNILPATGNEFVINIKDTS
                     VLNVISVVELYFSGNTVATQTYQYFQTFTIIAVIYFVLTFTVTRILRFIERRMDMDTY
                     TTGANQMQTEDLK"
     gene            46139..46903
                     /locus_tag="AC0DU4_000377"
     CDS             46139..46903
                     /locus_tag="AC0DU4_000377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015424 - ABC-type amino acid transporter
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HIN4236395.1"
                     /translation="MTQAILEIKHLKKSYGQNEVLKDISLTVHKGEVISIIGSSGSGK
                     STFLRSINLLETPTDGQILYHGQNVLEKGYDLTQYREKLGMVFQSFNLFENLNVLENT
                     IVAQTTVLKRERTEAEEIAKENLEKVGMGERYWQARPKQLSGGQKQRVAIARALSMNP
                     DAILFDEPTSALDPEMVGEVLKIMQDLAQEGLTMIVVTHEMEFARDVSHRVIFMDKGV
                     IAEEGKPEDLFTNPKEDRTKEFLQRYLILNENQRAN"
     gene            complement(47102..47317)
                     /locus_tag="AC0DU4_000378"
     CDS             complement(47102..47317)
                     /locus_tag="AC0DU4_000378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236396.1"
                     /translation="MAKSNFEKVESVVGWVRDKKITGYRISKETNAREMSIIALAQGR
                     AKVKNISFETALGLIDFYEKNHEKFED"
     gene            complement(48188..49438)
                     /gene="ilvA"
                     /locus_tag="AC0DU4_000379"
     CDS             complement(48188..49438)
                     /gene="ilvA"
                     /locus_tag="AC0DU4_000379"
                     /EC_number="4.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004794 - threonine deaminase activity
                     [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="threonine ammonia-lyase IlvA"
                     /protein_id="HIN4236397.1"
                     /translation="MLSSKDIIKAHKVLNGVVVNTPLDYDHYLSEKYGAKIYLKKENA
                     QRVRSFKIRGAYYAISQLSKEERERGVVCASAGNHAQGVAYTCNEMKIPATIFMPITT
                     PQQKIGQVRFFGGDFVTIKLVGDTFDASAKAAQEFTVSENRTFIDPFDDAHVQAGQGT
                     VAYEILEEARKESIDFDAVLVPVGGGGLIAGVSTYIKETSPEIEVIGVEANGARSMKA
                     AFEAGGPVKLKEIDKFADGIAVQKVGQLTYEATRQHIQTLVGVDEGLISETLIDLYSK
                     QGIVAEPAGAASIASLEVLAEYIKGKTICCIISGGNNDINRMPEMEERALIYDGIKHY
                     FVVNFPQRPGALREFVNDILGPNDDITRFEYIKRASKGTGPVLIGIALADKHDYAGLI
                     RRMEGFDPAYINLNGNETLYNMLV"
     gene            complement(49488..49844)
                     /locus_tag="AC0DU4_000380"
     CDS             complement(49488..49844)
                     /locus_tag="AC0DU4_000380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HIN4236398.1"
                     /translation="MNITNLFSIKTGCDETDRQLQKLFFQLDLQLGELTDQLRKLDSN
                     FVPRSQFVDTLDLNDVEYKEILNYFIFHRNDSEESLVEWLYDWISTNRYELPKEFSIR
                     MAHKYHESVTEVFGDE"
     gene            complement(50082..50318)
                     /locus_tag="AC0DU4_000381"
     CDS             complement(50082..50318)
                     /locus_tag="AC0DU4_000381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236399.1"
                     /translation="MLADQNKADWSYDENAVINIYDDANFEDGRLHMTFEQFFKLAQI
                     AREEGLEIHSPFERAGATKSARYIAKWILRNKKH"
     gene            complement(50425..51447)
                     /gene="ilvC"
                     /locus_tag="AC0DU4_000382"
     CDS             complement(50425..51447)
                     /gene="ilvC"
                     /locus_tag="AC0DU4_000382"
                     /EC_number="1.1.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HIN4236400.1"
                     /translation="MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDV
                     IIGVRPGKSFDKAKEDGFDTYTVVEATKLADVIMILAPDEIQQELYEAEIAPNLEAGN
                     AVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGN
                     AKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAG
                     YAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGSRVITEQVKENMK
                     AVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDD
                     AFKIYN"
     gene            complement(51513..51989)
                     /gene="ilvN"
                     /locus_tag="AC0DU4_000383"
     CDS             complement(51513..51989)
                     /gene="ilvN"
                     /locus_tag="AC0DU4_000383"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002927678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:1990610 - acetolactate synthase regulator
                     activity [Evidence IEA];
                     GO_process: GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase small subunit"
                     /protein_id="HIN4236401.1"
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATEDPNVS
                     RITIIIDVASHDEVEQIIKQLNRQIDVIRIRDITDKPHLEREVILVKMSAPAEKRAEI
                     LAIIQPFRATVVDVAPSSITIQMTGNAEKSEALLRVIRPYGIRNIARTGATGFTRD"
     gene            complement(51982..>52458)
                     /locus_tag="AC0DU4_000384"
     CDS             complement(51982..>52458)
                     /locus_tag="AC0DU4_000384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="HIN4236402.1"
                     /translation="RQLVTSGGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQMTN
                     QELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAYGI
                     KNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMVPAGKSNHEMLGVQFHA"
BASE COUNT        16065 a        11278 c         9214 g        15901 t
ORIGIN      
        1 gggagaggga taagaataga agcaacttta tcactattca agtttttcac aacagctcca
       61 ctaattagag atagaaattg agaataaact acatttgatg aaagaatata gaatagataa
      121 tctttattta atgagttttc atagttcgaa atagccaacc atccatcgtg tattgcacca
      181 tcaacattca aaatataagg tctaccaaaa ctcatagaat tagttaacaa aaatgtacct
      241 ttttttacaa atctagtttt gttaagccct gattttttga ttttttcttt aacattattt
      301 atatactttt cacccttttc agtatcacct atttttatcc aatttattcc atctacttca
      361 gaagtaagat aatctttgat tggtcgtgga gagccacctc tgacaatttc aaccaatgta
      421 gaaaacctca cccactccca agtatcagga atatcataag gaacatcaat ttcttgagta
      481 cttccatcag caaacttccc ataatgtttc ttatgtgctt caagtatata aaaaggcgta
      541 aaaatacgcc tatagataat ggggttgaaa taggtttatt gttgatgaga ttgtagataa
      601 ttcaattttt tacttccaat cgaatattca aagcctccac cttttctgcc tgtaattgtt
      661 catcataaaa ttcaatatct tcaggatttt ccccttgaca acctcggcag aaatattctt
      721 ccgctcgatc aggattcaaa aatcgacaag cacaaacaaa acagtcgcca tcatcattta
      781 ttgagataat atagtagatt gaaataagat gtaaacaaat cgattaggaa agttaaatta
      841 atttctagaa atttttagca gatgtagtgt actattctag tctcaattta ctatggcttc
      901 aaatatatct ttcgaaaaaa tatttacaga tgtgtaattt tgaagcttgc aaaagttagt
      961 aaacttgtag atttcgattt gaagtaactt gttttcttgc ccgatattgt ttttgaaatt
     1021 gaatttttcc atagtgactc cttgattttc ttctacacgt ctgatgataa atctaattcg
     1081 caaaagagtc aagaggattt ttcgaaaaat aaatagcgac cgaaatcgct attttaaggg
     1141 ttataggtat ttgatggctt agactgctgt gtgactgttt acccacaggc aatctttctt
     1201 ctatattagt attagtaaag gtctaaataa ttatcaattt cccattgtga aacgaaggtt
     1261 gcataacttg cccattcgat tcgtttggct tcaaggaagc tagtgtagat gtgatctccg
     1321 agagcagctt taaccacttc atcttctgtc aaagctttca aagcgttgtg aagagttgat
     1381 ggaaggtctg taataccagc ttccttgcgc tcttctgctg tcatgatgta gatattttct
     1441 tcgataggag ctggtgcttc gattttattt tcaataccat acaaaccaac ttccaaaaga
     1501 acagccatag caatgtaagg gttcgccatt ggatccactg aacgcaactc aagacgagtt
     1561 cccataccac gtgaagcagg tacgcgcaca agtggcgaac ggttacgacc agcccaagca
     1621 atgtaaacag gcgcttcata acctggaacc aaacgtttgt atgagttaac tgttgggttc
     1681 atgatgacag tatagttgta agcatgcttg atcaaaccgc ctaggaaatg gtaagctgtt
     1741 tctgacaact gcattccttt tggatcattt ggatcaaaga aggcgttatt tccttctgca
     1801 tcaaacaagg acatattaca gtgcatacct gatccagcaa taccaaattt tggcttcgcc
     1861 ataaatgttg cgtaaagtcc gtgtttgcga gcaatggttt taacaacaag tttaaagatt
     1921 tgaatcttat cacaagcacg gagaacttca tcgtacttaa agtcaatctc atgctgtcca
     1981 accgcaacct cgtggtgact cgcttctact tcaaatccca ttttggtcaa gacattcaca
     2041 atctcacgac gtgtgttgtc cgcaaggtca gtaggtgcca aatcaaagta gccacccttg
     2101 tcattcactt caagtgttgg gtccccattt tcatccaact taaataggaa gaattctggc
     2161 tctggaccaa ggttgaagga tttgaatcca acttcttcca tgtgacgaag agctcgtttc
     2221 aaattaccac gagggtcacc cgcaaatggt tcaccttctg ttgtataaac atcacagatc
     2281 agacctgcaa cacttccatt ttcatctccc caagggaaga ctgtccatgt atccaagtcc
     2341 gggtacaagt acatatccga ctcattgata cgtacaaaac cttcaataga agatccatca
     2401 aacataacct tgttcgacaa gaccttatct aactgttcat ctgtagcagg aatttcgacg
     2461 tttttcatgg ttcccaaaat atctgagaac ataagacgaa taaaggtaac atttttttcc
     2521 ttgacttcac gacgaatatc tgcagctgtg attggcataa gttttctcct taatctatga
     2581 ctacttgcgg ttgcctaacc gcgaccaaaa ggtgactgta ctgaagcaaa acgcccctgt
     2641 tggaggagtt cattgtgaag tgcacgacgt acttcagtct gactaaccgc tttcttggat
     2701 ttcgcttcac gttcagcata ttttttctta atggcagcga tattataacc ttcagagata
     2761 taatctttga tttcaagcag acgatccatg tcattcaagg aatacatgcg acgatttcct
     2821 tcgtttcgat cgggcttgat caactcttga tcttcataat aacgaatctg acgcgccgat
     2881 agatcggtca acttcataac actgccgata ggaaaaacag ccatatttcg gcgaaattct
     2941 ttttccttca tttacaattt ccttctttct gtctattata gtctaaaaaa agacaaacgt
     3001 caattgataa tgttataaaa tgtaacatta tttttctttt ttctctaaaa agagacgaat
     3061 acgatcaata tcgtaattta cgataattgc gacaaaaact cccataaacg tttctgatac
     3121 acgcacaaac acgtacgaaa ttgtctcacc acttggaatt gatagggtaa tgattaacat
     3181 agctgctaca ccaccaataa cccctgcttt gttattcatg gctacatttg tcataatggt
     3241 taacatggtg cagattggaa caactaccaa ggtcacccaa aaggcttcgt ggaaaaaggt
     3301 atttaataag aagaagacca aggcatagag tccaccgata ctatttccta gaatacgcga
     3361 agtcccaaaa tgaacactct catcaaaact ctccctcagg ctaaaaacgg ctgtcaaagc
     3421 accaatttga agacctttcc agccaaaaaa gccaaaaatc aagagaacta gaaaaacagc
     3481 aatacctgtt ttaaaggttc gcataccaag tttgaactgg gatttatcga atttatattt
     3541 tttaaaataa ctcataatct caactttcta tttccatttt atcataaatc ggtgattttt
     3601 atgagtaata gttgagagga agcgttttta ttttaagcaa aagaaaagag gaactttcat
     3661 ccctctcttc tttgatttgt ttataaaatc ttatttttct gtcaaggctg caagtcctgg
     3721 aagaacctta ccttcaagaa gttccattga tgctccacca cccgtactaa tccatgagaa
     3781 cttgtctgca cggccaaggt taatcgctgc ggcagctgag tcaccaccac cgatgattga
     3841 tttaactcct ggttgtttca cgatagcgtc catcacaccg attgtaccag cttggaaatc
     3901 tgggttttca aatacaccca taggtccgtt ccatacaact gttttggcac cagtcaaagc
     3961 ttcgtcaaat ttggcgatag attttggacc gatgtcaaga ccaaggaagc cttcagaaac
     4021 tgcttcacct tcagtgtcac gcacttcagt gtaaccagca aatgcgttag cttcttttga
     4081 gtcaactggc aagatcaatt taccatttgc tttttcaaga agagctttcg caacatccaa
     4141 tttgtcttct tctacaagtg agttaccgat ttcgatacct tgtgctttgt agaatgtgta
     4201 agtcatccca ccaccgataa ggactttatc agctttttca agcaagtttt cgataacacc
     4261 gatcttgtct gaaacttttg aaccaccaag gatagccacg aatggacgtt ctggagtttc
     4321 aactgcttct tggatgtagg caatttcgtt ttcaagaagg aaaccagcaa ctgctttttc
     4381 aacgtttgct gagataccaa cgttagatgc gtgtgcacgg tgagctgtac cgaatgcatc
     4441 gtttacgaag ataccatctc caagtgatgc ccagtattta ccaagttcag gatcgttttt
     4501 agattctttc ttgccgtcaa catcttcgta acgagtgttt tcaaccaaga gaacttgtcc
     4561 atcttcaaga gcgttgattg ccgcttccaa ttcagcacca cgagtgacac ctgggaaaac
     4621 aacatcttga ccaagttttg ctgccaagtc agctgctaca ggagcaagtg atttaccagc
     4681 tttatcagct tcttctttca cacgtccaag gtgagagaaa agaattgcac gtccaccttg
     4741 ttcgatgatg tacttaatag ttggaagagc tgctgtgata cggttatcgt tagtgattac
     4801 gccatctttc aatggtacgt tgaagtcaac acgaacgagg acttttttac ctttcaagtc
     4861 aacgtcttta acagtaagtt ttgccatgtt acaaaaactc ctttatttat tttattcgaa
     4921 actattatat cacactttgg aaatataagg aaagatttca caagattttt cgatatttaa
     4981 tctttatctt ctcttttccg tctcaaggtc aaggctaaac tagcaagacc aaggctggct
     5041 aagcctgcta ttagggcttc attagcatca gctgttcctg tatttggcaa ttgtttgctt
     5101 gcttcttctg atttaactgc tgtattttga gctggttttt cctgtgtagc tactactgct
     5161 ggtactgttt ttacttttgt tccaatttca acaatttctg gaatcgcttc ttggatgact
     5221 tctgttgaac gaagacgacg ctgaccgttt tcatcaactt caaagacatg tcttaacagt
     5281 ccatctcgtc cctgtatgat gactcgttgt tccccaacta gcatctcagt attttcatgc
     5341 tcttgacgat gaaaggcaac cttttcctct tgaacttcca atttaggagc cttttgttga
     5401 tcagaagccg gttgataagt aggttttgga aggactttgt tttgtggtgc tggtttagca
     5461 ggttgtggtt tttcagcaga ttcataaaca aaggcataat gagtaaagtg tggtgctgta
     5521 aagataacat gactatccgt ttgttcaaaa gccaattcta ctgcctcttt gccttcaggt
     5581 aagaaaaata ctttcttaac tttcttatct ttttcaattg ggattttcac aatagaagcg
     5641 taagagagat caacatcttg acctttttca tccaaacctt ctatttcaaa gacatgagca
     5701 tcttctccag caaagtattt cttctcttca gcacttgctt gaacacgctc tactttcaaa
     5761 cccttgatga cagtcttctc tttatttgag aagtgtactt caacacctgt tttactatca
     5821 gaaaagactg ctggcttgtc ttctttcaat aaagcaacca gatcttttag actctgtttc
     5881 gctgttgcaa gctcttctgg actcaaatct actttttcaa ccaaggcctt gtttttctca
     5941 agaagcggag ctagggcaga acctgaagga tggtttggtt tggcagccaa gagttcttga
     6001 acctcacctg ttaagcgatc aagttctgtc ttttcttcct taaatttctc ttgaccattc
     6061 agagctttat gagcttctgt caatttatta agtcggtcat tgacttgatc ttgggtgcta
     6121 gtttcatggt ctttcaacac ttgttcggcc gcttcaattg ctttcaagaa agcttctttt
     6181 acttctggtg aagcaaagtt atagaccacc ttgttcttag cagcttcaac ttctgctaat
     6241 ttctgtttga ggtactcatc gttcaatgct gcttttggag ataccaaaac atcaaagttg
     6301 acttcatgac cttggtaacg aagcgtcaag gtttgacgac cagtcttttg agcatcgtaa
     6361 ccagaaattt caactccctc atcagtaaag gaatgttctt ccatggtgtc attgctataa
     6421 gccactgcaa agcgtccttc agacaagtct aagctatcac caactaggta atcttttttc
     6481 ggttcctgac ttacttcaat tcccaaaata gttttcggac ttgcttcgtc ttggccagtg
     6541 acagtcactg acaaattagc atttactggt tgtcccaaat attggagagt aagattctgt
     6601 tctcccttat gatgcgtatc aaaacctgat actgatacac ctgcgtgagt taggcgaatg
     6661 agttcgtcct cagttcctcc ttcatactga actcgaagaa caccacctct aaggtccaaa
     6721 tcctcccctt cggcgtagct tgttttctta ggtcctgttt ctaggctgac tgacttgatt
     6781 cttctgtcat cttttggaac ggaaactgct aggacattac taatttcctt gcctggcaac
     6841 tgggtacgat aataaagaag accagattga tttgtcaaat ccaatggtgc acttgctagg
     6901 tctcctccaa cttcgctctt caaggttgcg agtggagttt gagaatttgg attatcataa
     6961 acggtaatag ttgctccagc cggtacatct gcaaagccaa cttgtacctt gttattgcct
     7021 agagaacggg ctgcagcctt ggccatcgga atattgacac tctcagtatc aagcttttca
     7081 tacattttcc agttatagat acgaatagcc ttccatggag ttccattgtc agaagtgaca
     7141 acattcaagc gccagtcttg agcagtgatt ggtttatcaa gagtgatatc tgtcacgtgt
     7201 gctttgttgc cacggacttc cttagctagc ttccacttac catctgcatc tttataataa
     7261 aggtcaaagt ctttggtgtt catcaagcca tcgttaacag actcaccacc agcccctgca
     7321 tgatccatga cccatctaac aacggtacgt ggcttggtca aacgaatatc cacactacca
     7381 ctcaactgag ctgaagacca tttatctgac aagctagtaa tggtaccgtt caacatacct
     7441 tcaatacctt ctccaccttc tgtatctggg aaggtacttc cgataacagt agcccctgga
     7501 acgatgtttt ctgctagagg tcttggaaga cttgtgtctt ggacagtcat cccccactca
     7561 aaggttgtgg ttgcagcttc tgaacgaact ccatttttac cgactgctac aaccttcagt
     7621 tcttgagttg taccctgagc acttgctgag cggctaactt ttggtagata aatagttgta
     7681 gaagatgagc cagttagtaa tttccagctg tctccatctt tttcataaac ttcatagaaa
     7741 tctgcatcct tgttgccttt aaattgcaca actgcttccg cttcttgggc atttttaaga
     7801 gattgtttca ctacagaaaa gcttgtcggc gattgtggct cttggtgatt gtccgagata
     7861 gttaattgtc ctaggttaaa ctgataatct tttacagcac cttcatgctc gaaaaatagt
     7921 ttgactgcat agatggtttt acccgctagt gagctaagat caaattcttc atttgtccag
     7981 ttgtcagaaa gggttagctc tttccatgca tctgcatcat cgaatttgta gtctggagtt
     8041 gtagagaatg ccatataaac tttagaacct tttcctccct tgtgggcaac acgaagtttg
     8101 gtcttctcag ttacttctaa cttagtagaa taaagtctca catcctgatc tgtcttaccg
     8161 gctacatcac cagagaattt aagggaattt ccgccattat aggcatctgt aaaatcatat
     8221 tctgcacgaa gtttttcccc tgttgaagtc tgccaccagc gccatgttgg aagaacacct
     8281 gatactgaac gataattcca ctcagaatcc ttagaaacct taccatctac gaaccatttt
     8341 ttaccatgac ctgtattaaa agaagtagta aaagtattac ctaccgctgg cgtacggtcc
     8401 gcaactaggt tagcaatacc ataccaatct ttgtcacctg gtttttgacc agtagggtct
     8461 ccttgataac ctgtaaagaa gatatcttca tttttatgat aatcttcacc agtttttcct
     8521 aaacttgtaa tggtatctgg ggcaaataaa ccaagagaaa ggcgcaattt cccattttcg
     8581 tctaaaatgt cattccactt aacctttgtc ttgtaggaac caccctgttg caattccaaa
     8641 cctgcaaata catcataagg attacgacca atccagttgg cagttgcaat agtgtaatca
     8701 tttttagcct tatcccagtt aaagttagca aagaagttat ctgccggaac cttatctcct
     8761 tctggttgca tgaattggta gttgtattct cccaaaccat cttgatggta acgtccatag
     8821 ttataggtca tggcatcata ccaagaatac ttgattggat ggtttacctt agcagcatat
     8881 tccttgctat agagcataaa ctggcgcatc ttttctccaa gaggtttaac caaatctcca
     8941 gttgtttctt ggttgatgaa atagccatca tagccataat acttggccat gtctaccaat
     9001 ttacgggcaa ttgggaagct accatctgcg tcttgcttca aagcttcagc aaatctttct
     9061 tgatctgcaa tactattaga ccagttgaag aagagtgtac cgtatacagg aaccccgtta
     9121 cggtgacctg catcaataac gtcaggagtt ggtacgagac cttcccagaa gaccattgaa
     9181 tctagatatt gccaatagtc aaaagcatag gccttgaact cttctccacc aacagaagca
     9241 tggtcttttg ctttagaatt ggtgtttgat aaggcttgaa cttttgcttc cttgctagct
     9301 ttttcattga ctaaatgacc tgtccgacgt gaagcgagga caacagatcc gcggttaata
     9361 gcatcatctt cacgagcacc tggttcccat tttaacaatt cttcccaaga attaaatttg
     9421 atttcctttg gttttaatgt tttttctgta tttttaggga catctggctg gacttctttt
     9481 tcagtcttat tagcttctgc tgctggctta gactcatccc cttggttagt tgcttcgggc
     9541 tttgcttctg tttccttgtc agacttaggt tttgcttctg cagatggtgt ttctgcaacc
     9601 acctcacctg ctttttcctc tggtttagct gcgctagctg cttctgcctt ttctagcttg
     9661 ttttctctag catgttcccc ttcattctgc ttatcagctt cattggtcga atgctcactc
     9721 tctcctgaaa caagctctgt attagctccg ctattttcag gaactgcagt ttcttcagcc
     9781 aaggctggac cagcaaataa aacagcacca atcatcagcg agcaggctcc tactgataac
     9841 ttacgaatac tgtaacgaca acgtctttca aaaaatggat tcttcatttt ctcctcctaa
     9901 aagattgatt ttgttgtttt aaagaaagcg ctttatattc tgtagttttt tatcaaactc
     9961 tagaaccatg ataatcacat ttttatccta aaacattttt agacaaaaaa caataactgt
    10021 ttgcacaaat ctaaaataag gttaaaaact cttaaaaata atacacttat caattataat
    10081 tttcttttac aaacttgaca ttaacacttg ttagatttac ttttatcctt taaaatagaa
    10141 taggagatat tccgcgatta tttttcggag gaaaaagaaa tgtccattaa ttggcaggaa
    10201 attttatttc actttttagg tggtctgggg ctattcttat atagcatcaa gaccatggga
    10261 gacggtttgc aacaagctgc tggagatcgc cttcgttttt acattgacaa atatactagt
    10321 aatcctttct ttggagttct ggttggtatt gggatgactg ctctaattca gtctagttct
    10381 ggtgtaacag ttattacagt cggcctggtc agtgccggtc tcttaacctt acgtcaggct
    10441 atcgggattg tcatgggtgc taatattggg acaactgtca catcctttct catcggtttt
    10501 aaattaggta actatgccct acctatgctc tttatcggtg ccgtctgtct cttttttacg
    10561 aaaaatcgga cagtcaataa tatcggacgc atcctctttg gtgtcggtgg tatctttttt
    10621 gccctcaatc tcatgagcgg cgcaatggct ccactcaagg atttacaggt ctttaaggac
    10681 tatatgattg agctaagtaa gaatcctgtt ttgggtgtct ttgtcggtac cggcttgacc
    10741 ttgctaattc aagcttcttc ggctaccatt gggattttac aaaacctcta cgccggcaat
    10801 ctaattgacc tacagggagc tttgccagtt ctatttggtg acaatatcgg gacaaccatt
    10861 acagccatca ttgcctcttt aggggctaat attgcagcta aacgggtagc aggagctcat
    10921 gttgccttca acgttatcgg aacagtcgtc tgcgttattt ttctagttcc ttttactgtc
    10981 ctgattcatt ggtttgaagc tacgctaaat ctagcaccgg aaatgaccat cgcctttgct
    11041 cacggaacct ttaatattac caacaccatt gtccaatttc catttatcgg agctctggct
    11101 tactttgtaa ccaagattat tcctggagag gacgaggttg tcaaatacga acccttatat
    11161 cttgatgaac atttcatcaa acaagcccca tctatcgctc taggaaatgc taaaaaagag
    11221 ctcttgcact taggaaacta cgctgctaaa gcctttgacc tttcctataa gtacatcatt
    11281 gacttggatg aaaaagttgc tgaaaaagtt gctgaaaaag ggcataaaac cgaagaagca
    11341 attaacacca tcgatgagca attaacacgt tatctcattg ccctttcaag cgaagctctc
    11401 agccaaaaag aaagtgaagt gctcaccaat atccttgatt cctcccgtga tttggaacgg
    11461 attggagacc acacggaggc tctactcaat ctgactgact atcttcaacg gaaaaatgtt
    11521 gaattttctg atgccgcctt gaaagaatta gaggaagttt accgccaaac tagtgacttt
    11581 atcaaagatg ctctggatag tgtggaaaac aatgatattg aaaaagcacg cagtcttgta
    11641 gaacgtcatg aagcaatcaa taagatagaa cgtgttctca gaaaaaccca catcaaacgc
    11701 ctcaacaaag gcgaatgttc aacacaagct ggggtcaact ttatcgacat catctcacac
    11761 tacactcgtg tatcagacca cgctatgaac cttgctgaaa aggtttttgc agaacaaatc
    11821 taagaaccaa gaagctatcc atcataattg gatggcttct tactttttcc taagcaagac
    11881 taggctgaat gaaactgaaa gagtattctg cagatatata gtatattgaa actagaatag
    11941 tacacctcta tttctaaaac attgttagaa atcgatttga ctgtcctgat cgatttgtcc
    12001 tgttattatt tcattttact atagtggatt aaattaaaaa agtataatgt attgaatcta
    12061 taacagtaca tcttgactgc taaaatattt ctataaatta atttgacttt ccttatagag
    12121 atgttcacat cttatttcaa ttcatgatac aatccagttc ctaaaacttt gctagaaatt
    12181 aatttggctt tccgaattaa tttgttcaga ttttatttca tttcaatata ctgataaatc
    12241 cattcactag cacagggcaa gagggagtcg ctattgattt caacggtagc aggtacatac
    12301 agaggactcc tacctcagat atactgcaat atcatcgtat gcaaaaaacc tctgagattt
    12361 ttctcaaagg ttctgatttt gctaattgct gttctcaacc gctgcagtaa caaaggcagt
    12421 gtagagttct tctggtcggt ttggacggct tgacagttca gggtgatact gacaagctac
    12481 aaagaattta ttttcaggaa tttccacgat ttctaccaaa cgattgtctg gagaaactcc
    12541 tgaaaagaca aaacctgctg cctcaaactg ctcacggaag gcattattaa actcataacg
    12601 gtgacggtga cggcgttgca ccacttcttg attgtgataa gcagcagcag ccttagagcc
    12661 acgtttcaac ttagacggat aaagtcccaa acgaagggtt ccacccatat cctcaatatc
    12721 aatctgatca cgcatgatat caatgatagg gtattttgtt tctggtgcaa gctctgcaga
    12781 attggcacct tcaagaccta aaacgtgacg agcaaactcg atacatgtca actgcattcc
    12841 caagcagact cccaacattg gaacatcatt ttcacgcgca tagcggatgg cttggatttt
    12901 cccttctgta ccacgttgac caaaaccacc tggtacgatg atcccgtccg catcagacaa
    12961 gagttctgct acattctctg ctgtcacatc attggcattg acccaattga ttttaacttc
    13021 tgcatcattg acatagccag agtgtttcaa ggcttcgacc actgagatat aggcatcttg
    13081 caactccaca tacttaccaa caagggaaat cttaacttgt ttcttgaggt tcatgacctt
    13141 gtccaccatg gctgaccatt ctgtcatagc cgctgctggt gcgtctaatt tcaaatgatc
    13201 acaaacaatt tggtccatcc cttgtgcctg caagttcagt ggaatttggt aaaggtgttc
    13261 aacatccaac gattcgataa cggcttctgg tgccacatca cagaactggg ccagtttatt
    13321 tttaattcct tgaccagctg gctcttctgt acgaataacc aacatatttg gttggattcc
    13381 caagccacgc aattctttga cagagtgttg ggttggtttg gttttcattt caccagcagc
    13441 cttgaggtaa ggaagcaagg ttgtatggat atacatgaca ttatccgcac ccacatctgc
    13501 cttcatctga cgaagagcct ctaggaatgg caaggactcg atatctccta ctgttccacc
    13561 aacctctgtg ataatgacat cagagtcggt cgttagagcg gcacgcttga ttttttcttt
    13621 caaagcatct gtgatatgag gaatgacttg aacagttgcc ccaaggtatt ctccacggcg
    13681 ttctttacga agaacttcac tgtaaatttt cccagttgtc acgttggaat atttgttgag
    13741 attgatatcg atgaaacgtt catagtgacc caagtccaaa tctgtctcag ctccgtcatc
    13801 tgtcacaaaa acttccccgt gctggtaagg actcatggtt cccggatcaa tattgatata
    13861 agggtcaaac ttttgaatgg ttactttgag accacgattt ttcaagagac ggcctagact
    13921 cgctgccaca atccctttcc caatagacga taccacacca ccagttacaa aaatatattt
    13981 cgtagacata gattcctctt tctaaaatgc tcaaggtctt gttaactacg aggggatata
    14041 gaaaacaaga ccctactaat aagaataatc tgggacgact gcaccagatt cacaactaat
    14101 actcttcgaa aatctcttca aaccgcgtca acgtcgcctt gccgtagata tgtgttcctg
    14161 actttgtcag tcttatctac aacctcaaaa cagtgttttg agcagcctac ggctagtttc
    14221 ctagcttgct ctttgatttt cattgagtat aaaatacaag aagataactt cttgaaaaaa
    14281 caaaaatagc tccctaagaa ctagggagcc ccgacctcta aaagaggtgc ccaaacaata
    14341 tgatacctaa aaataggata attgtcaata gctaactctt attcctcgct ggtttcagcg
    14401 tcgtcatctg aaaactcgtc gtcgtcttcg ttgagatcca catcttctcc caagtcatct
    14461 ggagcgattt cgttgatttc tgcatcataa gcttccactt catttttttc atcatctgga
    14521 ttttcatcat cgtatgaaag agctggatct gcttcgtatg catcttcgtc ttctggatca
    14581 tctgcattgt agtcaatggc atctgaatca ccatccataa aggcattgac acgttttttc
    14641 ttagcttttg gtgctacttc atcgtcgtca ttttcttcaa gagcgatgat ttcttcgtcg
    14701 atttcgtcca caccatacca tgaacgaaga ccccatttgt tgtccccaag tgagatgaag
    14761 ctaccgtcaa agttcaactc tgtgtagaac agaggcaaag cttcgcggat atcgctgttt
    14821 gatgttccaa ggtagttttg aatttcgttt acaagatcgc taaaatgcat ctcatgatcg
    14881 cgaccacgaa gttctaatat agcacgcgct acctcaatca tagatagttc acttttttct
    14941 tgcccagcaa atacttctaa ttccaaagcg tttctcctca tttatactac tatcgccaga
    15001 gcgaacagac tctgacctca ttttatcatt tactctttat tttacgataa ttttgcggaa
    15061 tagtcaaagg ttaaggggga gaaagtggca ggattagact aattccaata taaaactcct
    15121 tcctttttct gttgctccat tttccacaaa tccaagcgac ttgaaacacc tcctagaagc
    15181 atgattgtag gtgtagattt ccttgactct caattctttc catcctttta ctcgagccaa
    15241 ttcaatcaaa gcacttagaa tcttttttcc aagtcctcga tgttggtaag cggaattccc
    15301 aatcacaatg gggagattat cctgagatag tgtaatatcc ccaattggaa accattctcc
    15361 cttctccttg acttcaatcc aaaaaagctc accatgccga tccaaagagg taagatatga
    15421 ttttttaaat caaaaacaga gtaaatcttt cctcgcaagc ttgcgcatag agatgatata
    15481 gttcatcacc accatctcta tcccactcag cagaaatcgt atcccgacct gccaataaag
    15541 cctgataagc cctgtgatgc ccatctgtaa tcagcaaaca atctccaaag gcaagaatac
    15601 tgattggatc gacttggttt gtttctgccg actggtaaag catctgaata tcttgcaact
    15661 tcttttctga taaatatagt tgagtcggat gaagatctac tatattgact ttcatttctt
    15721 tctcctaaag ggaattcgat actcacttct gtttgccttt aaatcgccat tggaagcgga
    15781 gcttgtcata gaagggaaac tcgataaaca agactcccaa acccacacag aaactggcaa
    15841 gaacatctga tgggtagtga actcccagat agactcttga taccagcaca ctgactaggt
    15901 agaggccaag gacgatttgt acgatttttc tccagacctg atctttaatc cgctgactaa
    15961 gaataacaat caaagtccct accatcagcg ttacagctag agaatgccca cttgggaagg
    16021 aaaatccctt ctcctccacc agatgtaaga tagctggtcg tgggcgctgg tagatatttt
    16081 taaaggtcac gattaaaaga cctgccaaag ccagatttcc cagcatgaag aaactttcta
    16141 tcttccatcg cttacgataa aagacaaaag ctataatgac aacccaagtg ataatcactg
    16201 gaatatcaat cagatgtgtg agggatcgaa aaagaatagt caaataatct ggtaagtctc
    16261 ctcgaatggc agtctgaatc gattggtcaa aaccgaccag cgtttcaggg taaaatttga
    16321 ccatatagcc aagaataacg aaaagtaaaa gggcaaaact gcccttcatt aaaaatgttt
    16381 gtttatcttt catagtgttt taaggttggt ttcaaaagga cgtacaacaa ccagaatgaa
    16441 acggaaaaga ttacaccctc aatcaagtta aaaggtaata ccatggtcat taggtagttg
    16501 gaaagtccca aaatttttcc aatatcaaag ttagcaaact tagcgtacaa aggaacagca
    16561 taaacatagt tgagaaccaa catggccaag gttaaaccaa cagttccagc tagagagcct
    16621 agtaggaaac gaagggttgt ccgttccttt ttccaaatca aagcaaatac gatgacaaaa
    16681 actcccaaag ctacgatatt catcggcaaa ccaatgtaag tattcactcc ttggctgtta
    16741 agaagcaatt tcaatagtga gcgaagcaag agcactccta gagcagcagg caaatccatg
    16801 accaccagac ccacaaggac tggcaagata ctaaattcga tcttgaggaa agatgccgct
    16861 ggtaaaagcg gaaagtcaaa gtacatcagc acaaatgaga tggctgatag aattgcaatg
    16921 gtcgaaagtc gacgtgtgtt tgtcataaca ggttcctcca attttctata aaatcagaag
    16981 aagttggaaa ggattcctct atctattctc actttttata tcccaaaagt tccctcttac
    17041 tctattaaag aaaaacaaag caagtggtta caatccggct ataaatctat caaaacagac
    17101 aaagctattc tttcgtcttc tcccatccag actatactgt cggttgtgga atctcaccac
    17161 atcagcttgc gctcgcggac ttctttaaag agaaggaaat agagattttt cttttagact
    17221 aggcgacaag ctgtaggcat aacttctggt taggcaaagc ttgtcaacaa agtataaaag
    17281 gaaaagatca tttcctagtt aaagtcaccg ccggtcggga atcacaccct gccctgaaga
    17341 ctcttttatc ataacaaaaa acgcttgcaa gcgcaagcat tttgttcatt ttcatttttt
    17401 atttcaattt atccacttca taggtatgga cgagctcaag acctgcaaag ttctgctggc
    17461 gaagagcctc atagacaatc atgcagacgg tattagacac attgagactg cggacatgtt
    17521 catcattcat gggaatacgg agagccttct caggatgttc tcgcataaaa tcttcaggta
    17581 agcccttgtc ttcacgtcca aagagaaaat aatggtcctc gtcagtcgat aaatccacct
    17641 cagaatagac tttttccgcg aatttcgaaa tcagatagag ttttcccttc atctgagata
    17701 tgaaatcttc caaactctcg taaaaataaa tctctagctt atcccagtaa tccaatccag
    17761 cccgcttcat cttgcggtca tcaataggaa agcccatagg cttgatgatg tggaggggag
    17821 aattggtcgc agcgcaagta cgcgcgatat tgcccgtatt ttgtggaatt tgaggttcaa
    17881 ataatacaat gtgatttgtc atgacttgct tcctttcacc attgcaaaaa aatagccaca
    17941 ctgcccggag tcaagctcag caaacagcgt ggttaaggca tcgttaactt acctcacaac
    18001 aggtttgaag taaatcagcg aaactacttt cttagtataa cactttcaga atcattgtca
    18061 atagaaatga cttgattttt tcaatttttt caagctattt ccaagggttg taaaatcgtc
    18121 cctgattctg caagataagt agtaaactaa ctactaaaaa caaggttgcc aagagcaagg
    18181 taatatagtc tccttttttc aaggcctgat aactatacca tgtgcgtttt ttctctttcc
    18241 caaagcggcg aagctccatg gcagtcgcaa tggtatcaat gcgttctagc gagctaaaaa
    18301 tcaagggcgt aataatgagc agattgcctt tgattcgttg cataagagaa gctttcttgg
    18361 ataattccat cccacgcgcc tcctgagaca tcttgatagt aaagaattct tcctgcaaat
    18421 ctggaatata gcgcaaggtc aggctgacag aataagcaat cttatagggc acaccaattt
    18481 gatttaaact ggaagcaaac tgactaggat gggttgtcat caaaaagata atagccagag
    18541 gaatggtgca aagatactta atggccaaat ttagcagata aaagagctcc tggctggtta
    18601 gagtgtagac accgattccc tgccaaatca cacttctctc tccataaagt ccaaccccat
    18661 actcgggaga aaagagatag accatcaaaa cgtttaaaac ggcaaatacc gtcgcaaaaa
    18721 cggctacaaa ggaaacatct ttaaagcgaa tttctgataa atagaggaga aagactgaaa
    18781 agatggcaat cagcaagagc attctggtat catagctaat catggccgcc aatgatacca
    18841 gaatgaaaaa gagaagtttc ccagctcctg acaagcgatg aatcacagta tctctatgct
    18901 ggtaaccgat taatttagct tgcatccctc tctcctttct ttgtaaaatg ccgttaaatc
    18961 cagtggatcc acatctagtt tcttagccaa gttaaagatg gaggtttctt ttagattggc
    19021 ttttactaac agctcaggat cgctcaacag actggctgga acagtatcgg caatcaattc
    19081 tccatccacc atgacaagga cccggtctga ataatccagc atcaattgca tatcatgggt
    19141 aatcatgaca atggtatgcc ctttttgatg taactcttcg agaaattcca taatctcagt
    19201 atagttcttc tgatcttgac ctgcagtcgg ttcatctagg agaataattt cagctcctaa
    19261 gaccaaaatt gaagcaatgg tgacacgttt tttctgacca aatgacaggg cagaaatagg
    19321 ccaattacgg aattcataaa gtccacagat tttcaaggtt tcatatactc tcgtttcaat
    19381 ttccttctca tccacacctc gcaaacggag ccctagagcc acctcatcaa aaatcatatt
    19441 ggttgaaatc atttgattag gattttgtag cacatatcct actcgttccg cccgctctgc
    19501 aacagaatcg ccttttatat cctgtttttc ccaaagatag cgtccttccg tctgaataaa
    19561 gctacttata gccttggcta gagttgattt ccctgctcca ttttttccga caatagcaat
    19621 cttttcaccc tttttaatat ctaaatgtag ggattttaaa atcggtctat catcataaga
    19681 aaaagatact tcctctagtc taaagagtga ctgcaatgct ggggtttctt ttgccagttc
    19741 attctgcaac tgaacctgac cttttgagat agacaagtta tccagattcg ctaattgttc
    19801 ttccttgact aaatccacac ccaattgacg gagagtggtg agataaaggg gttcgcgaat
    19861 tccattttgg gtcaacaaat cagtcgccag taactggtca gggctcccat taaaaaggat
    19921 acgaccatcg tttatcaaga caatccgatc cacagggcaa tgcagaacat cctccaaacg
    19981 gtgctcgata ataagggtcg tcgtcccctc ctccttatga atctggtcaa tcaattcgat
    20041 aatatcctga cctgacttgg gatcaagatt ggcgagtggc tcatcaaaca agagaatcgg
    20101 actttcatca atcaagacac cagccagact gactcgctgc ttttgtccac ctgacaaatc
    20161 ctgagggcgc tgatccagta aaggaagaag gtccagcttt tcagcccatt tataaacacg
    20221 acctttcatc tcatctaggg ctgtcacatc attttccaga gcaaacgcca aatcttctgc
    20281 cacagacaag ccaataaact gcccatctgt atcctgcaaa actgtgctaa ccagatgaga
    20341 cttatcatag atgctcatat caaaggctgt ttgacccttt atcaaaaatt ctccatatgt
    20401 ctgacccttg taaatattgg gaataatccc attcaaacac tgacccaagg tagatttacc
    20461 tgatccagat ggtccaacaa ttaagacttt ctctcccttg taaatggtca agtctatccc
    20521 ttgcaaggtc ggttcttgtt gtgtttcata ccggaaagag aaatccttcc actcaattat
    20581 agcttctttc atcttactct cttcattcgc ttcttagact tctattttat cataaatcaa
    20641 gcccttcttg cagtctctcc tattaaaatc ttagcgccaa aaagattcct atcctagctt
    20701 acttacctaa ctaatctata aacatcgaaa aagactagtt gcccagcctt ccccatcatt
    20761 ttatactctt cgaaaatctc ttcaaaccac gtcagcttcg ccttgccgta ggtatggtta
    20821 ctgacttcgt cagtttcatc tacaacctca aaaccatgtt ttgagctgac ttcgtcagtt
    20881 ctatccacaa tttcaaaaca ctgttttgag caacctgcgg ctaacttcct agtttgctct
    20941 ttgattttca ttgagtatta gtcctttttc aaacttcctg cacgagtttg ggttcctgca
    21001 taggcaagta agagaagagt tcctgcaata gctacagata caccattggc aattcccgca
    21061 acaatccctt gtgcaaatac tttttctgcc gcttcttgat aaatcacaac atctccaagt
    21121 ggtgccaaga caccccaaac aagggcattt gcaagtagtt gaatgaggtt aaaaataaga
    21181 atatctttcc agtcaaaaac accattgatc acgcgaacgt actttctaaa aagtcccaca
    21241 actaaaccaa agagtccgct agcgataatc caagtccacc atagaccata accagcaaga
    21301 gagtccttga ttgcatgacc aatcaacccg acaagcaaac cgataatcgg tccaaaaata
    21361 atagaaagta gcgcttgtac cgcatactga agctggatgc ttgtatttgg aacaggggtt
    21421 ggaatgttga tcatcccgat gacgacaaag agggcagcgc caattccgac agcaacaact
    21481 tgtttaattg taaatttaat ttccatacta ttctcctatt ttatccttct attttcttta
    21541 tttcaatggt ccaagatgaa ccgacaccta cattataggc cttggcaaag gaaccttggt
    21601 tgatagccaa acctaaacga tagagagagt tgatgtaaag gatgggttgc ccaattctca
    21661 catctgcaaa tgatttgcca tagacaacct gattttgata gaccagcata tcagcatgat
    21721 agatggtcac ttcaaaacga tcaccaaatt ctggttccag cttgtaaaat tcttcccgtg
    21781 tgatagaggt ccaaagcgaa ccgaaacgca catccagaat atcaatggct cccttcacca
    21841 gatgatcttc tatgatggtc gctacgactg gaagctctac aatctgttcc acactgagct
    21901 ctggccctac ttcctcaaaa gtaatgtgac cactggccag tttagcacca gtataggcat
    21961 agacatcacg accgtggaag gtataagaat gctctgtgtt ttgacgccta ttggccacct
    22021 cagaaatctc acgaatggct acaatgccaa cgtgtttctt gataaaggaa agcgtcccat
    22081 tatctggcgt gacaatgtat tgattttttg cagtcttggc aactacactc ttacgtttcg
    22141 aaccgacacc tggatcgaca accgatacaa acgtcgttcc ctcaggccag taatccaccg
    22201 tctgaaagag acgatagctc ccctcaaaaa tattataagg cgtgatatcg tgcgtcaagt
    22261 gatggatttt taaggttgga gactcttcta aagccactcc aatcatagcc gataccgcac
    22321 catcaaccag accaaagtct gattgtaata ccagtaaatt attattcatt ttatctcctt
    22381 gtatatcctt tatcatacca tatttcagag aaagtcgcta atagctattt caattggtta
    22441 gggtatagtt ttaccttata gcgaattttc actaaaagct cttgttatta gctagtaggt
    22501 gcattttttc ttgaaaaagg gtatgatagt tacatcatga aaaagtaggt tttattatga
    22561 aaattatcct tgtcggaggg ggaaaagttg gttttgccct ctgtcgctcc ttggttgcag
    22621 aaaagcatga tgttttgctg attgagcaag acgaagctgt tctcaatcat attgtcagtc
    22681 gctttgatat cattggtatc cttggtaacg gggccgattt tgccattctt gagcaagcca
    22741 gcgtccaaga ttgtgatatc tttatcgccc tgactgagca cgatgaagtc aacatgattg
    22801 cagcagttct agccaagaaa atgggagcta aagaaactat cgttcgggtg cggaaccctg
    22861 aatattctaa ctcttatttc aaggaaaaga atattctcgg tttttctctt atcgttaatc
    22921 ctgagctctt ggctgcccgc gctatcgcga atatcattga cttccccaac gccctgtctg
    22981 tcgaacgctt tgctggtgga cgcgttagcc tcatggaatt tgtcgtcaag tccaccagcg
    23041 gtctttgcca aatgcccatt tctgattttc gtaaaaaatt tggtaatgtc attgtctgtg
    23101 cgatagagag ggatcatcaa attatcattc caagcggtga catgactgta caggataaag
    23161 atagaatctt tgtcactggt aaccgtgtcg atatgatact cttccataat tattttaaat
    23221 cacgcgccgt gaagagcctt ctcatcgttg gagctggtag aattgcctat tatctattag
    23281 gtatcctcaa agatagtcgt atcgaaacca aggttattga aatcaatcct gaaatcgcta
    23341 gcttctttag cgagaaattc ccaaatctct acatcgttca aggagatgga accgcaaaag
    23401 atatcctgct ggaagaaagt gctcaacact atgatgccgt tgcgactcta acaggagtcg
    23461 atgaggaaaa tctgattaca tctatgttcc ttgacagggt aggtgtacag aaaaatatta
    23521 ctaaggtcaa tcgtaccagt ctcctcgaga ttatcaatgc gcctgatttt tcaagtatca
    23581 tcacacctaa aagcatcgct gtagatacga ttatgcactt tattcgtggt cgagttaatg
    23641 cccagtattc agaccttcaa gccatgcacc atctagccaa tggccaaatc gaaaccctgc
    23701 aattccatat caaggaagcc aataaaatga ctgccaaacc tctttctcaa ctgaaattga
    23761 aaaaaggggt tcttattgca gccattattc gaaagggcaa gactattttc ccaactgggg
    23821 aggatatgtt ggaagttgga gacaagctcc tagtaacaac cttgttgcca aacatcacca
    23881 agatttatga cttgattgcg aggtaagaaa tgaataaaag tatgattcgt tacctccttt
    23941 caaagttact tttgattgaa gctgttctcc tcttggttcc tgtggctatc gctgtctatt
    24001 accgtgaatc gagccaagtc tttacagccc tcttttcgac catagggatt ctcgtattgt
    24061 taggcggttc agggagttta cagaagccaa aaaatcaacg gatttatgcc aaggagggag
    24121 tcttgatcgt tgccctctgt tggatccttt ggtctttctt tggtggtctc ccctttgtct
    24181 tttctgggca aatccctagc gttattgatg ccttttttga aattagttct gggtttacaa
    24241 ctactggagc aagtattttg aacgacgttt cggttctcag ccgttccctc ctcttctggc
    24301 gaagttttac ccacttgatt ggagggatgg gagtgcttgt ttttgcactt gctattatgg
    24361 acaatgccaa aaatagccac ctagaggtga tgaaggctga ggttccaggt cctgtttttg
    24421 gcaaggttgt atccaaacta aaaaacactg cccagattct ctatctcctt tatctagctc
    24481 tcttctccct ctttgtcatc atctattatc tagctggtat gcctctctac gatagttttg
    24541 tcattgctat ggggacagcg ggaactggag gctttaccgt ctataacgac ggaattgccc
    24601 actatggcag ctcactgatt acctatctgg tcagtatcgg agttctggtt tttggggtaa
    24661 atttcaacct ctactactac ctcatgctcc gtcgcatcaa ggccttcttt ggtgacgaag
    24721 aacttcgggc ttacttggtc attgtactgg tttctacagg cttgattagc ctcaacaccc
    24781 tctacctcta cccagggttt tcaaagagct ttgaaatgac cttcttccag gtttccaaca
    24841 tcattacaac aactggtttt ggatatggag atattaccaa ctggcccctc ttctcccagt
    24901 ttatcctcct tttcctcatg gcaatcggtg gctctgctgg atcaactgca ggtggactca
    24961 agattattcg aggcctcatc ctttcaaaaa ttgccaaaaa ccaaattttg tcaatcctat
    25021 cgccccaccg tgttttgact ctccatgtga atcaaacggt gattgataaa gatacccagc
    25081 ataagattct caagtacttt gtcatctatg ctatgatttt gctagcgctt atctttattg
    25141 tcagcctaga tagcaatgat tttctggtcg tgaccagcgc tgtctttagc tgtttcaata
    25201 atatcgggcc tattctagga accacttcta gtttctcaat ctttagtccc atctcaaaaa
    25261 ttctcctctc ctttgcaatg attgcagggc gcttggagat ttacccaatc ctccttctct
    25321 ttatgaaaag aacttggtct aagagataaa atacaaaatc cctcttttta caattgtgaa
    25381 agagggattt ttatattaaa aagggggaac gtttttaaat ccaagcctgt ctgtaagcaa
    25441 agttcttact caaataaaag atggaaaaac ttactacaca gcttggtaat gctccaatac
    25501 aaattgtaag gctttacttg gattctttgt taaatgaata tattccattc ctctggtagc
    25561 aactatctga atacctaatc tttctgcatc caccttcatc tctctataat aactccgaac
    25621 ttgtggagcc agaataatta aatcataaac acccataata tcataatgag ctccgtacgc
    25681 tcctgaattc gcaatcactc taacttctgc taattgagcg ccctcgttaa ttgcattggc
    25741 taattgcgca cttgttccag accctgcaca aagaaccagt actttcaact ccttactttt
    25801 tatttcatct aactcaccag gcattatttc acttgtctcc tcctctaaaa taatatcatt
    25861 tgagcttgca acatcttctt tcatcagtaa ctgtctatca tacgctctac agaatggcaa
    25921 ataaatcaat atgtcgacaa ctaaaatcaa agataaaaat acaaaggaga tagattgaaa
    25981 attcgttcca attaacaatc ccaagggacc aggaaaggcc caaggtaact ggatataaaa
    26041 tccattcatt ccaaagaaat caataaagac ctttcctaga aatacattca ctggtggagt
    26101 catcaaaaaa ggtacaaaaa gatagggatt caaaataact ggcataccaa atagaagagg
    26161 ttcattcact gcaaataaaa caggagtaat tgtagcttta cctaccgatt ttaattgttt
    26221 agaccgcata aagaaaatca aaataaatgg tacaacaaag gtagcccccg ttcctccgat
    26281 agcagcgata taatttccga aattaggcgt taaagaatga taaggaaact gcccatttgc
    26341 aagaagttga gcattctctt ccatattgct cagttgtaaa gctgtaacag caggtaagac
    26401 aatagatggt ccatgaattc caacaaacca aagcaaagcg cacataaacc aaatcaacat
    26461 catagcagga tatgattctg cccccttaaa aataggagtc aatagttgtt gaaatacttg
    26521 ggcaaaagga acatctaaac taaaccgaga tacaatatct aacaaaccac taataagtaa
    26581 aacaaaagaa aaaggaaaaa tatctctaaa agcttgtgat atagccccag gaacttcctt
    26641 aggtaaatga atagtaatgt ctcgcttaat acagaatcgg taaacattta cagtaataaa
    26701 ggcactgaca aacgaagtta tcaatccttg agatcctaaa tagtttgtcg acaaacttgt
    26761 agatcccgtt ttctcatcaa ctacaagcgt tacagttaat acaagatagc cacatatggc
    26821 cgccaacatt gcagaagtat catttattac ctttccagga ggcatttttc tattaacatt
    26881 tccagccaat gactttgcaa ctgtccctga aacaataaca cccaaaactc ccatggttag
    26941 catatacact ttcctcatcc aggcaatagc tggactcggt aactctactc cgaaattttt
    27001 aggaatcata ataataatca tcaaaaagct tgaaaacata attaaaggca tagtagcaat
    27061 gaatccatct ttaatagcca tcatataatt attagtagaa attttttcaa atttcccttg
    27121 ttgcttttca atggcagcga ctaacttatc cataaaaact cctcctgtaa aaaatttaag
    27181 ctcatagtta aaatatatta aacatcagtc aaatcgctaa ccttaattcc gttttagccc
    27241 ttttacccaa agagcacttt tcttaatata tctcttctgt gtttcataat caacaaagaa
    27301 aagaccatat cgcttattgt agccattcgc ccaagaaaat tgatcttgca aagaccatat
    27361 aaaatagcct tgaatattga ctcccctatc tcgagcctct aaaactttgt gtaaatgttg
    27421 ctcaatataa cggattcttt tactgtcatc aataatatca ttctcgccct ctggcttaac
    27481 ctctttaagg gctgtaccat tttcagttaa ataaatgacc ggatgttgag gatattcttc
    27541 tttgatacga agcaacatat caaataaccc ttgaggataa atattccaat cccaatctgt
    27601 tgtcggaata ccaggctttt ttacaaattc acctagagca tttaatttaa aagaagactg
    27661 tccttttatt cctgttgaat taaattcttg tctattttca cctttgtatt cacgaataaa
    27721 ttctgaacga taataattca tcccaaacat cgtattaaga ggtgcagctc ttttcataat
    27781 ttctaaatca ccatcttcaa taataaagct agaattatta gcttccaata tttgattcaa
    27841 gtgaaaaagc gtgtcatcac tgtagtagcc caaaaaagtt ccatctaata gaaatttatt
    27901 attataaaca tcataccgtt tagctgccaa aatattttct ttttgcccat caataggata
    27961 gcctggcttt aaagcatgaa tacaacctac ctttccctca atccctaatt gatgaaattc
    28021 gaggactgca agagcatgcg ccaacaacat gttatgattt gcttgaattg cttcagataa
    28081 ttgaaaatgg tgattcggag gaaactgacc tcctatgtat tggcctgcag caagagacat
    28141 cagttcattg attgtaaacc aatgcttgac ttctgtaaat tcttggaaac aaaagcgagc
    28201 atatcgtatg aaacgatcaa tattctctct attcaaccaa tcccctgttt ctaacatttt
    28261 ctgaggcgaa tcaaaatgat gtaaagaaac aaacggaatc acattatatt ttaagcagga
    28321 ctgaaagact ctatggtaat aacgaacagc caatatattc ggctccccat ctatatcagg
    28381 aaatatacga acccaagaaa tagataaacg caaagcctgc aaaccatgtt ctgccgccaa
    28441 agctatatcc tcttcgtaac gataataaaa atcactagct ggatctggta agaacggact
    28501 attttcttgc aaataaacat cccacatatt tattcctttg ccatctaccc tagttgcacc
    28561 ctctacttga taagcagcgg tagcagctcc taataaaaac tccttcggta aggctttaac
    28621 ctgtaaattt tccatgacta atcctcattg caaaccaata tgttcttcaa tctttcgaat
    28681 tcgttcatat tcatcaataa aaaactttac ctgatcatac aatagcatcg ttgtcatcaa
    28741 agtatcttga ccatgaatca tgataaaact cacttcaaaa ttatctccat atgcctcctc
    28801 cgctaataaa ttagtctgtt ctcgatgggc agacactatt gagtcgtttg cagactcaac
    28861 caattctctt gcctgttcaa aatatccatc tctcgcaaac gccaaagcat ccatcaaatc
    28921 tgaccttgca tctcctgcgt aagcgacaat tgtaaaacca agcatattta tttcttcttt
    28981 tgatttcatc tttcttcctc ctcaatcttg aaccatcttt tacacatcat tattaaaatg
    29041 acttcgctac gatacaaata gaaagtcgac cctaaatatc ttaaaaatcc ttaaatttca
    29101 taatatttag gatcaatctt ctctgaatac cttggttcat tttctagact tatgatttat
    29161 aagtggaaac cagcgtaatt ttttgctact tcaattacac gataaacatc caaattagat
    29221 tggaatagca gttcgtgccc acggatataa ttcaacacat ttttccactc atcttgagct
    29281 tgccttgttt ttccggttgc ttgaagatat aaagccttcg ccatcttgac aacatattca
    29341 cgatgataac tgagctgttt ccattcatcc ttttgactat ttaataactt agaaatattt
    29401 tcctcaataa ttggtaaaaa attatcagct agattgtaag ctatataata atgattcgct
    29461 aaaacatcac tttgacggct gccaattgca ttaaaataat cacaagagga ataaatggat
    29521 aatttttcta aatattcaac aacagactgc caattttccc catacaaagc agaaaagtat
    29581 tcttcaatca attcttcata atttcttgtc ttcttccaga gcatttgccc catgacataa
    29641 ttaggaaaat tatgagggaa tccggcacgt aattcttgac acgaaatgta cccgttcaaa
    29701 tgtaggttgg aaagataaga tacatctctg taaatagttt gactaatttt catatagcct
    29761 aaatcgccat aatgagcacg ccctaaagga tagtcatata cgaaactatc tcctttaaat
    29821 gctttttgcc actcaaaaag ataagataaa ttttcctcaa gagaattcgg aagtataatt
    29881 ttattacgca gataaggttt aggcgtaggt atggaattgt caaaatctac atctgcataa
    29941 ctcatttcaa atgttcttgt aatcggtgca aacatcatgg taaagcgttc aggattatct
    30001 aatttttctt tctgaggtgc ccataacaac tcatgataaa gcagaaaaca aatctttgta
    30061 tctaatccct cactcgttaa agccctatcc aattgattga gaatacgaat atactgatcc
    30121 gaaaccaatt cttgtctaca gttttcgcat tcacaaatat tattacgagc atccgacaac
    30181 catacatgta agtagttaac atcaggtctt ttcttggcat aatccttgat aatttctacc
    30241 atcttatcag ctacatctgg atttgaaaaa tccaggctgg ttaaaatcgg agccgtatta
    30301 aacaattctc gtttcccgtt tatttcagcg acatagggtt tcttctcctc tgaaatacta
    30361 agacctgatt cccagccaaa ttttgaagag taacctaaaa cttcacctgt ccatccatga
    30421 ccaacacgat gatgaataag acctcttttt tgcaattctt tatccaacct atcactcaat
    30481 tcttgtacta attcatttga aaattgttct ttatttagat atggattaaa ttcatgttca
    30541 taccaacgtt tcaaaaaaga gtagggattt tcaaactgga tgaaaaaact gttcatccca
    30601 atcttaggta gccaatcaat gaaatctagt atattttcaa atgaatccgc tccctctata
    30661 catactcccc tatgatagta actggctgtt tcatctatag atagctgttt atctaaaaaa
    30721 tcttcaaatc gtaactctgg aacaaagtca tgtccgcgcc ctggtctagt atacacaacc
    30781 ccaaattcat gaaacattcg gtaaattcca ataagtaaac ctacaattgt attagactca
    30841 attctcccct tacccttgtc taatgagata agaacatggt ctcttctatc ctctttattg
    30901 actaatccta caaaaatatc cgcttccttc tcctcgacaa gttctatgtc agtcttaaag
    30961 acccgattta tatagtaact taattcctct aaggcaaagc tagaataagt atttttctgc
    31021 ttatcaaata ctctgataac catcttattt ccctccaaca gtagcttttt ctttttcaag
    31081 attgcgttta tctgcaattt tgaagaatgg ataataaatt gctacagaaa ccaaaatcaa
    31141 aacaacttgt aatagagctc ctcgccaact agctcctgtc gcaaggaagc ctcctatgat
    31201 cggtggcatt gtccacggaa ggattacacc tgttgtatag ggtactaatc ctacagccat
    31261 tgatacatag gtaattaagg cattgattgt aggagtagca ataaacggaa tcagcataat
    31321 cggatttaaa actgttggaa acgtaaatag aatagctgta ttgatattaa aaatagacgg
    31381 tataatagct agcttaccta atgttttatt cgcacgactc ttactaaata ggaagagaca
    31441 aatcgcaaga ccaatagtcg ctccaccgcc accaataaat acaaataaat ctttaaacgg
    31501 taatgtaata atgtgttgga gtgtttgtcc tgcagccaca gcttcttggt tttctgtagt
    31561 aaattgtaac caaactgggt ctacaaaagc atttaaaact tgtcccccat taactccaca
    31621 gaaccaaaag aatgagttta caataacaca tagaatcata cctggaagcg ttcctgcaat
    31681 taacttaagc ggtgttccaa caattgcacc taggagtccg ttgagacctc ctgcaactcc
    31741 tgccgcttca agacctttta agaccagagc ccacaaaaca aaagtagtaa agccaggtaa
    31801 aagagctgaa aatgatttac ttaccacatc tgggacacca cttggcattt ttatcgtaat
    31861 tccgcgctgg ataaacatac gataaatctc tgctgtaacc aatccaatag taatcgccat
    31921 aaacaaagaa gatgcattca gactagaaaa tggtattgcg ccgccaaata actgcttgac
    31981 ctgctcccca tttttatcat aaaccatact cgaaaaacga ggtgccatca atacaaaact
    32041 ggataaggct atgatccctg ccgacggacc atctgtacca tatccttccg acaacctgta
    32101 ggcaataccg aaacaagcga ccaaggagat aatcgctact gttgactgat tcatagttgt
    32161 caagatactt agcaatccaa cactattcag ccaatttgta aaagcctctt gaggccaact
    32221 gattagaata agaaataaag agccgactaa aatcaaaggc attgccatca taaatccttc
    32281 acgaatagct ttcaaatgcc gttggttgcc aactttttca ccaaacggag cgacttttgt
    32341 ttctaaaaac gctaaaatat tgttcatcac cggaactcct ttttttattt tttataaatt
    32401 aaatatacca ctaacagaaa gcgttgtcaa tatatttttt gttattttta caatattttt
    32461 ttctttgtat agaataataa ttttaattga ttttttctta tgtttaatat aaaataaacc
    32521 aaaggaggaa acaaatgatt acaaaacaat cagccttttt acaaaataga gccactatac
    32581 tggagtttct atatcgaaat ccagcaacat cccgtacaga tattgttaat gaaacaggac
    32641 ttactccagc aacaacgact aacatcataa aagagctaag cgaacagtcc ctcatatacg
    32701 aaactggtga tgaatttagc gagttttccg gatctggaag acgtagaaaa actatttcta
    32761 tcacagataa tattccgtat gttgttggag gtattgaaat aaacgtccta ggtatctttc
    32821 tcagtctatg tgacttacaa gggaaaactc ttttcgagac agaaattttg aatgaagatt
    32881 atcctatttc agaaatcaat tccaccatta ccaatatgat aaaaacagct atagagtacg
    32941 tccctttgga aacaaaatta cttggatttg gcttatcaat acctggacat tataacaaag
    33001 actccggaag tatcattaca aacaacccca tatgggaatc ttttaattta ttaaatgtaa
    33061 ttaaaagatt caattttcct tttattgtaa aaaataatat cgattgtatg gctataggac
    33121 aatacctttt taatccacac aatacccccg ataactttat tttcctgcac gctggattag
    33181 gtatttacac ttcctttttc acaaaagaaa aaataggagc ctctaaaaat ccttatatcg
    33241 gagaaattgg acacaccatt gtcgaattga atgggcaata ttgtgaatgc ggaaaaaaag
    33301 gttgtttaca aacatatatt tcggatgctt ggttaatcaa acacgcccaa ttattattta
    33361 aaaattccca actaactgta ctaaaaagcc ttgtaaagac tgaaaaagac attcatttag
    33421 acaccctttt aacggcttat aatttaggcg actccgcttt acgtcaacaa attgataaag
    33481 gagtcaattt attagccact tctattgcaa atctcctcct catcaatcct gctgataaaa
    33541 tctatatcaa cagtcaattg cttaattatc aacctttcac tcatgaagtc agggataaaa
    33601 tccaagacca gctccacttc gttcccttta ctcgtaatat agaaattgaa attttacctt
    33661 acaacaaaca tcgtggaagt ataggagctt gtgcattagc tatcgtcgct tttttcatag
    33721 aacatagcaa tgtattacaa gatattattt caccttaata tattagaaat ctatagacct
    33781 gtttaaatca actataacct gtagtagata tctcgtattt agacaatatg aaaacaagac
    33841 gacttccata taggaaaccg ccttctctct atgttgagtg atttatatta aaataacttt
    33901 tcttctagct gcattttatt attataaaaa cattcatcat aaccctgaac ttaaataacg
    33961 atttttattc aagatacata ctcctagaat aaactttata tgaaattctc atttttgttt
    34021 ttacaattct ccttagttaa atcttgttta atatatgttt tacatatagt atttagcgcc
    34081 acatagtact gaactctctc caaaaacggt tattcctctt tgaatagggc gttatcacaa
    34141 gaaaagcatc tccacgtttc aacttcatat ggctcaaaaa caatcaattg atgctaaaac
    34201 ctgtacctag atgtttcggt tcataaaacc atgaaactgt aaaagtggat gaaattgata
    34261 gcgatagtca aatcaagagg catcataact ctaaaaagtc acaatatata agttcatcct
    34321 cggaaaaata tcattctaat tgttgaaatg cctacatgaa aagaaacgtc aaatactcat
    34381 gaaacaacga atacaggtat caaaactatg acaaaacaag tccctaaatt tactaaagac
    34441 actgctcaac tttacacctg taaatggttg ttgtataata aagttacaaa gatgtacgac
    34501 cacactgttg taaatcatag tgttcgcgaa tatattactg atagcatttc tacaaataca
    34561 attgaagaga ctggatagac tttaaacgaa atatgtcagt gttttggcat tcctagcctt
    34621 catatcattt aaagaattct atagacaaaa tttttcccaa tacagacact cgtaacaact
    34681 gcttcatttt tctaccaaca tatttaggaa caggataaga tacaagagga ttaatccata
    34741 gatcagttct ataccaatct aagacaaata agctaaaaaa acgattgata ataagcaaat
    34801 agattccaaa ttttctctat ctgctcattt taataaacaa tactagtgta actatccttc
    34861 cagtcagaag cttgtcaaat cacaccgaaa attcttctaa aatttatctc gttaggcaat
    34921 caagcaaaaa ctcgacgata gtacaaacat tatcatacag aattgacttc ctaaattata
    34981 tactttagta aggttttcgt ataagaaaaa agattcattt tacatttcta aacattcttt
    35041 tctaagatga aaaacagaat ttttcgattg tgatttaaag caacaagaag attttcagta
    35101 tcatcctata gatacgagct aattaagaaa aactacattt tcgaatataa actacaataa
    35161 tataaactaa attttatagg aggaagacaa tggattggta cgattatatg atacaggcat
    35221 ccaaacaatc acaattcaac gcaagccatt ggtttcgcta tttgcgaaaa gttatttttg
    35281 aagactattc ttatttaaca aaccaagatg tagaaaagtt gctagactcc aaagaactaa
    35341 cccgttttca aaaaattagc ttgaagtatg cctttcaaga gcatactcca actcataaat
    35401 atgtgatttc attaaataaa cctgctaagt taaccaatgt tcaaaaattg atggagaaat
    35461 acaaacatgg ataaaatgaa accggtcttc caagccctaa ataaggaatt aattcaggaa
    35521 aatctgactt taacaattat ctgtgtcgat ggttatgtct tagaatatca tggtttacat
    35581 gccacacaag atgttgatgc tttttatgac caaaatcaga aaatcaatga aattattgct
    35641 cgtgtaggaa aacagtttaa tcttaacatc cacgaagagt tatggctcaa caatcatgtt
    35701 gcaaagcaaa tatgaacaaa caacctccct taagtttatg cgaatccttg tactcatttg
    35761 agaatctgac cgttttagta gtccctattg agtatgtgtt aggaatgaag atgatgagta
    35821 tcagagagca ggatttgcaa gatattggtg caattattaa atacaaaaac tttcattcac
    35881 cattcgatac ctttaaatat ttaaaagaca tgggatttga tactattgac ctctctgttc
    35941 tattagaaag ttttagttat gcttatggta tggattggtt agaaaaattt tttaaagaaa
    36001 atcaagataa acttcgcgaa ttttattaac agtatcaaac aagatgattg tcaattagcc
    36061 agtcgtcttg ttttttatga tgaaatgaaa taaaatctga acaaatcgct tagagaattc
    36121 cagtcaattt ctagcgctgt ttgagacgtt tcagtggact atagtaaaat gaaataagaa
    36181 taggacaaat cgatcaggac agtcaaatcg atttctaaga atgttttaga aataaaggtg
    36241 tactattcta gtttcaatct attatatttc agattcggtc cactattcct tcccaaaaac
    36301 attgcatatt gcgccgaagg aattgctcat actatcccaa gcacaaaacc ctcagtcgtt
    36361 tgaccgaggg ttccttttta ttattcaaga acttgattag ctcaatgcat ccaaggcgtc
    36421 atccattgaa agaacttcgt ggaagacacg ttgtgtcaat tcagtttttt gttctggagt
    36481 gaggtattta gtgtttacac agtatccaga gatacgtacg ataacgtctt cgcctgacat
    36541 gattttttcg taaacatcgt tcaagtccat aacgttcaag ttaacgtgtt gtccaccgtt
    36601 ttcgaagtaa ccatcaagga ttgttaccaa gttatcaact tgttcatcac gagtcttacc
    36661 aagagcgcga ggtgatactt gtgtagtcaa tgagataccg tcagctgcat aactaaagtc
    36721 aaggctagaa agtgagttca agttttgcaa ccaaccacct ttagctttgt tagatgggtt
    36781 agcacctggt gagaagaatt caagtttaga caagttcaca gaaccatctt cgttgaggta
    36841 tacacctttg tgaactggtg agttaccagt ttgtttagag taagcaacgt tagatgtgat
    36901 tgtcaaaagt gatactgtag cttctgcgtc tttgtatagt ttgtggctac gtagacgagt
    36961 tgtgtaagct tcgatcaacc attctgccaa ttcgtttgaa cgtgggtcat cttcacccca
    37021 gcgtgggtag tcaccgattg tttcgtaatc gtagatgtag ccatcttcgt cacggattgg
    37081 tttaactgta gcgtatttga tagctgacaa tgtatcaaca gtgttagcaa atccacagat
    37141 accgaatccc atgttggcac gttgtttagt tggcaagaag gccatttgaa cagcttcgta
    37201 gttgtaccta tcagtcatgt agtggatgat gttcaaggca tctacgtaag tgtcagtcaa
    37261 ccagtcaaga gatttttcaa agttcgcttt aactgattcg aattcaagaa cttcgtcacg
    37321 gattggttcg atatcaaata ctttgtagtc tttgtgaaca tcgtcgtaac caccattcaa
    37381 accagtaaga agggctttaa gaacgtttac acgagcaccg aagtactgga tgttgtggcg
    37441 ttgttcttca ttttctggat caagtggaga cacacagcat gagatacagc tcatttcacc
    37501 atatccgtct ttagccattg ttgttacacc ttcgtattgg atagaagagt gtttgtggct
    37561 catgtgcata cagtagcgac ggaagttgta tggcaatttg tcagtccaaa gaactgtcaa
    37621 gtttggttct ggtgagttac cgatgttgtc aagagtgttc aagaaacggt agtccatctt
    37681 agtaacacgg tgacgaccgt cgttacccat accagccata gaagttgtga taaaggttgg
    37741 gtcacctgag tacaattggt cataagcttt ggtacgagca aatttaactg tacgaagttt
    37801 cataacgaaa tcatcaacga attcttggat ttctgattca gtaaatgtac cacgagcaag
    37861 gtcacgttct gcaaagatgt ccaatacgat tggtacacga cctagagatg tagcagcacc
    37921 gttaatcaca cggcagacag ccatgaaagc aatgttaacc cattggattg cttctttcac
    37981 gttcatcgct ggtttgcgaa catcaacccc gtaaaggtca cccaggcgaa caacttgttg
    38041 caatgcttgg tattgaaggt ttacttcttc acgaagacgg attgtttctt catcgatttc
    38101 tttgattgca ttccagtcat ttactttttc ttgcatcaag tagtctgcac cgtaaagagc
    38161 aagacgtgcg taaacaccga tgatacgtcc gcgtgagtat gcatctggaa gaccagttac
    38221 agtgtgtgcg tgacgagcgc gacgaatatt tgaagtgtag gcacggaaaa taccgtcgtt
    38281 aactgttgtt acatatttag tgaagatttc gtgaacagct gggtctggtt cgtatccatt
    38341 ttctttcaaa gtagtttcag ccatacggat accacctttt ggcatgaagt tcaatttgaa
    38401 gagttcatcg ttttggatac cgaagataac ttcattttct ttgtcgataa atccagcagg
    38461 gatatcagcg atagatgttg gacgagtgtc cattgggaaa cgagtttctt cgtagtgtgc
    38521 tttagtttct tctacaattt tcttgatgtg aagtgaacgc tctgttggtc ctgcaaggaa
    38581 gctttcgtct ccatcataag gtgtgtagtt agcttgtaca aatcgtgata cacttgcttt
    38641 ttctttccaa tctacgcctt tgaagccttc ccaagctttg tcaaaaatat cttgtgcttc
    38701 aacaactgtc ttaacaacca tattaatgtc ctcttttttc tagtaacagt catctgttac
    38761 attcataaga caagtatacc atatagtaac cgatttcaac aagtgaaaat tccctatttt
    38821 tacactttct tttctaaaac agtctatatt ttatttcaaa ctgtattata tttttgaaaa
    38881 aataaagtcc ttttttcttt ttttcagaaa aaagggtata ataaaagaaa ataagcagta
    38941 acactcaatg gaaatcgaaa agcaaactag gaagctagcc gcagattgct caaaacactg
    39001 ttttgaggtt gcagatagag ctgacgtggt ttgaagagat tttcgaagag tataaaaagg
    39061 tgctaggcat gttgattttt cctttgttaa atgatttgtc aagaaaaatc atccatattg
    39121 acatggatgc cttttttgct gcagtggaaa tcagggataa tcctaaactc agaggaaaac
    39181 ctgtcattat tggaagcgac cctcggcaaa caggtggacg gggagtcgtt tctacctgta
    39241 gttatgaggc aagagctttt ggtgtccatt ctgccatgag ttccaaggaa gcttatgaac
    39301 gttgtcccca ggctgtcttt atctcaggga attatgagaa atacaagtct gtgggactcc
    39361 agattcgagc tatttttaag cgctatacag atttgattga acccatgagc attgacgaag
    39421 cctatttgga tgtgacagaa aataaactcg gtatcaagtc agcggtcaaa attgctcgcc
    39481 tcattcaaaa agatatctgg caagaactcc atctaactgc ttctgccggt atttcctata
    39541 acaagttctt agctaaaatg gcgagtgatt atcaaaaatc tcatggtttg acagtgattc
    39601 tacctgaaca ggctgaggat tttctcaaac aaatggatat ttccaaattt catggagtag
    39661 gaaaaaagac agtagaacgt cttcatcaaa tgggcgtttt tactggtgct gatttacttg
    39721 aagttcctga ggtgacccta atagaccgtt ttggtagact aggctatgat ctgtatcgaa
    39781 aggctcgtgg cattcacaac tctccagtca aatccaatcg catccgtaaa tcaatcggca
    39841 aggagaaaac ctacgggaag attctctgtg ctgaggaaga tatcaaaaaa gagctgactc
    39901 ttctatcaga aaaagtcgct ctcaatctac atcaacaaga aaaagctgga aaaattgtca
    39961 ttttgaaaat ccgctacgag gacttttcaa ctcttaccaa acgaaaaagt attgctcaaa
    40021 aaacacaaga tgctagtcag ataagccaaa tagccctgca actctatgaa gaattaagtg
    40081 agaaagaaag aggtgtccgc ctattgggga ttaccatgac tggattttaa agctcaatga
    40141 aaatcaaaga gcaaactagg aggctagccg caggctgctc aaaacactgt tttgaggttg
    40201 cagataaagc tgacgcggtt tgaagagatt ttctaagagt ataaaacctt gaagagttgc
    40261 cccttcaagg tttttcttat acaaataaac ggacaaaact gtaaagtagc aaaacactac
    40321 caagcacgat acggtattta ccaaaaaggg tgaagtcgtg ttttttcaca tagctggtca
    40381 agaagcgaat agccaccatg ctgaccgcaa aagctactcc catcgcgacc aagagcaaaa
    40441 acaattgccc aaagctcaag agttctccgg ctttcacaaa tttgaaaatc tttaaggcac
    40501 tagctccaaa cataacagga atcccaagat agaaggtaaa ttctgtcaca actgaacgac
    40561 tggttccatt taacaaacca ccgacaatcg ttgcacctga acggctagtc cctggtaaaa
    40621 gagcaagaac ttggaagagt ccgatataga aagcggtcgt ataaggaagc ttgtccaact
    40681 ctgttacact tggctcgata gcacgcgctt tattgcgctt ttccaaatag atgaaggcaa
    40741 ccccgtagat aatcaacatg agagcaactg aaaccatgtt atggaagtgg gtatcaaacc
    40801 aatcatcaaa tttaaagaca ccaagtaaag gtaaagtagc aatcaagacc ttcaaccata
    40861 gtctccaagt cttacgaact tcctgtttgt ccttagtcgg tttaaaagga ttgagcttgt
    40921 taaaataaat caccataact gctaaaatag caccaagctg aatcacgaca ttaaacatgg
    40981 acataaaggc ttcattttga ttttggtatt ggatgaattc ctctgctaaa atcaagtgac
    41041 ctgtactgga aatcggcaac cattccgtaa ttccttcaac aatcccgaag aagatagatt
    41101 ttaaaatttc aataagatac atagattact ccctatatta taattagcgc agttagctac
    41161 tgccaaagcc caagtggtat acttggaata agccactgtg gattagttca tttcctccaa
    41221 tcgcttgacg atttccgaaa ggatctaacc acagcttttg tttcaattgg taatgagttt
    41281 gataacgcat agacgtttta tctcgtctaa ggtaacaagg caaaaagttc gtggataacc
    41341 aagtagactt gaaatactat atctggaggt actcccatgc tttatgtggg cattgatatc
    41401 gctaaaaata aacacgatgt tacagccttg aatgttccag gaaaaactgt tcttaaacca
    41461 ctcacttttt caaataataa agctggtttt gaactcttag atctgtctct tcgacagctc
    41521 aaccaagact gtctcatcgc tcttaaactt ctttctgacc ccaatcgtga acaatttcaa
    41581 cacgataatc ggcaagtaga cctaaaaata ctggctagac atattcatcg tctcaagaaa
    41641 aaacagtctg attggaaagt acaatacact cgttgtcttg atatcatctt tcctgagttg
    41701 gataaaatcg ttggaaagca ttcagaatat acctaccaac tcttgacgcg ctaccctaat
    41761 cctcagaaaa ggattgaggc aggatttgat aagctgatag aaattaagcg attgaccgct
    41821 tctaaaattc aggatatcct ctcagtcgca cctcgttcta tcggaacaac atctcctgct
    41881 cgtgaattcg aaatcatcga aatcatcaaa cattacaaga ggctcattga caaggcggaa
    41941 acatgtgtca atgacttgat ggctgagttc aactcagtca tcacgacggt tactgggatt
    42001 gggggtcgtt taggggcggt cattttagcc gagattcgaa atattcatgc ctttgataat
    42061 cctgctcaat tacaagcttt cgctggactg gattcttcta tttatcagtc aggtcagatt
    42121 gatttagctg gaagaatgat caaacggggt tcccctcatc tgcggtgggc actcatacaa
    42181 gctgccaaag catgcgctcg cttttcacct gcttttaagg cctatcttaa gactaagtta
    42241 gaacaaggaa aacattacaa tgtagccatc atccaccttg caaaaaaact tatccgaacc
    42301 ctgttttata tcctaaaaaa gagctgccat ttgacgaaca aaaagtgatg taatttctga
    42361 aattaacaca ggattacctt tgaaaaaatg gactttttca agggcttttt gccgtgctct
    42421 aaaatcatcg ccaaatcatc aaattgaaat aagaaatagt ttagataaaa ctattgactt
    42481 ttcttatagt ttgtctttct tctatcttcc attatatcat actttttcag tctatggtag
    42541 ctctctttaa aaggctccga tactgccgcc acctccgcct ccagagaagc caccgccaga
    42601 acttccactt ccagaagata cggagtaggt acttgctgta tttgcgacac tagcataatg
    42661 gctcatttgc gcgcttgaat gataaaacat actgtgccag ccataagcta catagagatt
    42721 gatatctgga ttttcaactt gaatctgatg aaccttcatc aaatgactaa ccttgtccgc
    42781 atagccaaat aaggttgcat agaccaagag acgattccaa acaacaatac tttccaattc
    42841 agccttatcc agtcgtgcaa tctcacgtaa catattttca aaactggtcc agagatagta
    42901 gacctcagct cccgcttcat ttagaacacc atcacgatta tctagtcgaa gcttccaata
    42961 atagaaaaca gacaaaacta accctagaaa accaagtatt ggcaaaggga ggtaaagata
    43021 gccatgaacg tctaaactgt acaagaacaa accaaatccg ataaataggg gcaagatagt
    43081 caagacaccc atacccactt gcaaagtctt ttccaaacca gttaaaggac gatagtaatc
    43141 tgggagcccc cagaaggaaa ctcgttttct cactccttct tgcatctggt tcaatacctc
    43201 ttcaaaagaa gatttgagtt gaagccctct tgcttgaatc cgtttttcat cagaaacttt
    43261 ggctctacga taaagactat cagatacctt gtaatccgca aacaaattgg aaagagtggc
    43321 ttcttttttg cctgaaaagg ctagatttag acagtctctc tcaaatcttg acaaaccatc
    43381 ttctttcacc aatctcaagc caactgcatc tccttctgaa ataatagaga cattcccacg
    43441 gtctatcaca tctagcaagg tagcttgaat aagttgatca aaggtgaatt ttccagctcc
    43501 cttgaccaag ggactcactt cctccaagga ggtcgagtag actgcttctg ataaaaccat
    43561 aggctctaat tccattggtg gttcatagag acgatgattt ttggcatatt tgactgaagg
    43621 agtggtcttt cttctataaa taaaatagaa gcagacactc aataacaagg agatggaaag
    43681 gatcgaaggg aggacccaag taacgagttg tttactctga tctttttctc taacaatcga
    43741 gtcttctatc ttattaaact cttctaaacg attccctttc aagccctgat ccctagcgct
    43801 agcaaaatcg gtccgagacc aataggcatg caactcaact ccacgcttag ccggaagatt
    43861 gtctaaacgg atagtataat caaggttact cttttcaatc gttccctctc taaaaagttt
    43921 ccctgtatgg aaaaagagtt tttcagcccc cttgtctccc cttacatgaa attcaaactt
    43981 ttcaatagac tctgaactat ctgtcagagg ttgccaattt aattcagcga tatcatcata
    44041 aaggaaaagt aaatttttta agttccagac gaggtcaact tcaactatgt cgccctcctg
    44101 acctggatta tagactctca cagtataacc atccgcttct tctgttactt cgctagtcac
    44161 atctgctagt tctgcaccgt ttttcgcagc ctgaaccttt ggatgagggt caatgtcaaa
    44221 cccgctaggc atcttaccag cacgtccaag tcccacgatt tggcccttaa agtcctcctc
    44281 aaactggtaa actatcttct gtctaaactc tgccgtatta tctgcatgaa tatacaaatc
    44341 cccttgataa gagtttatct tgaaatcaat ggcaaaaaca gagagtggaa gaaggcaaaa
    44401 caagcctaac accagtaaga aaaaagtttt tttcatcaac taagccccct ttttatcttt
    44461 cttatcatta tagcattttt tcgtaagtaa aggcttactt atgttgaaaa attacgcatt
    44521 tttcgataaa ataggagaca gttatttttt aatagatcag aataggagaa atcatgagaa
    44581 aaatatactt atctattttc acaagtctct tgctgatgct aggacttgtc aatgttgctc
    44641 aagccgatga atatttacgc atcgggatgg aagcagcata tgctcccttt aactggaccc
    44701 aggatgatga tagcaacgga gctgtcaaaa tcgatgggac caatcagtat gccaacggat
    44761 acgatgttca aatcgccaag aaaatcgcta aggacttagg taaagaacct ttggttgtta
    44821 aaaccaagtg ggaaggtcta gtccctgccc ttacttctgg taagattgac atgattatcg
    44881 caggtatgag tccaactgca gaacgcaaac aagaaattgc cttttcgagc agttactaca
    44941 ctagcgaacc agttttgctt gtcaaaaaag attctgccta cgcaagtgct aaatctttgg
    45001 atgactttaa cggtgcaaaa atcacttctc aacaaggggt ctacctctac gacttgattg
    45061 cacaaatccc aggtgctaaa aaagaaacag ccatgggaga cttcgctcaa atgcgacaag
    45121 ctcttgaggc tggtgtcatt gatgcttatg tttctgaacg tccagaagca ctgactgctg
    45181 aagctgcgaa ctctaagttc aagatgattc aagtagaacc tggtttcaaa actggggaag
    45241 aagatacagc tatcgctatc gggcttcgta aaaatgacaa tcgtattagc caaatcaatg
    45301 ccagcattga aaccatttca aaggacgacc aagttgccct gatggatcgt atgatcaagg
    45361 aacaacctgc cgaagctaca acaactgaag agactagcag tagtttcttt agccaagtcg
    45421 ctaaaattct ttctgaaaac tggcaacaac tcttgcgtgg tgctggtatc actcttttaa
    45481 tctctatcgt cggaaccatc ataggtctca ttattggact tgccattggt gtcttccgta
    45541 ctgctcctct ctctgaaaac aaagccattt atggccttca aaaactagtc ggctgggttc
    45601 tcaatgtcta cattgaaatt ttccgtggta cgccaatgat tgttcaatcg atggttatct
    45661 actatggaac tgcccaagct ttcgggatca accttgaccg tacactggct gctatcttca
    45721 tcgtttcaat caataccggt gcctacatga ctgaaatcgt ccgtggtggt atcctagcag
    45781 ttgacaaggg acaatttgaa gctgcgactg ctcttggtat gacccataac cagaccatgc
    45841 gtaagattgt cctacctcag gtagtccgta acatcctacc tgcaactggt aatgaatttg
    45901 tcatcaatat caaagataca tctgtattga acgttatctc tgttgtcgaa ctttatttct
    45961 caggaaatac cgtggcaaca caaacctatc aatacttcca gacatttaca atcatcgccg
    46021 tgatttactt tgtcctcacc ttcaccgtaa cacgtatcct acgctttatc gagcgcagaa
    46081 tggacatgga tacctacact acaggtgcta accaaatgca aacggaggat ttgaaataat
    46141 gacacaagca atccttgaaa ttaaacacct caaaaaatcc tatggacaaa acgaagtgct
    46201 aaaagacatt tctctcactg tccacaaggg agaagttatt tctatcatcg gaagctctgg
    46261 aagtgggaaa tcaaccttcc tacgctccat taacctactt gaaacgccaa ctgatggaca
    46321 aatcctttat catggacaaa acgtcctcga aaaaggctat gacctcacgc aataccgtga
    46381 aaagttaggg atggttttcc aatcctttaa cctctttgaa aatctcaacg ttcttgaaaa
    46441 cacaatcgtc gctcagacaa ctgtccttaa acgcgaacgc acagaagctg aagaaattgc
    46501 caaagaaaac ctggaaaagg tcggcatggg agaacgctac tggcaagcga gacccaaaca
    46561 actctcaggt ggtcaaaaac aacgtgtggc catcgctcgt gccctttcaa tgaatcctga
    46621 cgccattctc tttgatgaac caacatcagc tctcgatcca gaaatggttg gagaggtcct
    46681 caaaatcatg caagatctgg ctcaggaagg cttgaccatg attgtcgtaa cccatgaaat
    46741 ggaatttgcc cgtgatgtct ctcaccgtgt tatctttatg gataagggtg tgattgctga
    46801 agaaggtaaa ccagaagacc tcttcactaa tcctaaagaa gaccgtacaa aagaatttct
    46861 tcaacgttat ctcatactca atgaaaatca aagagcaaac taggcagcta gccgcaggtt
    46921 gctcaaaaca ctgttttgag gttgcagata gagctgacgt ggtttgaaga gattttcgaa
    46981 gagtatcaaa taaaaagaaa aggctgcatc aaccgtgcag tctttttgct gtcctcaaaa
    47041 tgaaaaggca gattctctat ctctactact tgaaggtcaa gaatccaccg ttatccaaag
    47101 attaatcttc aaatttttca tgattttttt catagaaatc aattaagcct agggctgttt
    47161 caaatgaaat attttttact tttgcacgac cctgcgccag agcaatgata gacatttcac
    47221 gcgcattcgt ttctttagag atacggtagc ctgtgatttt cttatcacga acccagccaa
    47281 caactgattc tactttttca aagtttgact tagccatgtt tttctcctat tttcttcttt
    47341 ataatattta attgtatacg tttttactac ttttgtcaat aaaaaaaaca tatattcaac
    47401 gaaaataatt agttcagaat tttcttactt cctttttaaa tccgataata tataggtttt
    47461 gctagcctct acaccataaa tatttgctaa taaaaatact gtattattac cctcttaagg
    47521 tgcgaaatta ttcaagttct taaaaaatgc ttctctattt ccgtaagata gcttatttct
    47581 tcgatttaag aactgaagat gatagttcta acctttagaa atccaagcct tctctagctc
    47641 aaaaactcct atctttcttc ctcaataaat catctgagag ataggtattc cttatatcct
    47701 tcaaattcat cactcctttg gatattgagg tgctagccta gaagcagaca cccgattatc
    47761 taaaccatcc ttaatagaga tgacaagaca gataagctca gttaattact tatatatctt
    47821 tttaatatgg tatatttgtc aacaaaaaga aatcaaatca taccttatac tcaatgaaaa
    47881 tcaaagagca aactaggaag ctagccgcaa attgctcaaa acactgtttt gaggtttcag
    47941 atagagctaa cgtggtttga agagattttc gaagagtatt aaagacagta tgactatgct
    48001 tgtcaataga taggaaatca aaatgaagga tggaaatctg agccaaacat cataagtgct
    48061 ataatgaaca gaagtaagaa ttgcacgata agttttctaa aaccatagga atcgtcccct
    48121 ttcttcatct tcattatagc acatatacat cagttgtaca aataatatga tattttttta
    48181 ttagtcctca gacaagcata ttataaagcg tttcattacc atttaagtta atataagctg
    48241 gatcaaaacc ttccattcta cggatcaaac ctgcataatc atgcttatct gccaaagcga
    48301 tcccaatcaa tactgggcct gttcccttgc tagctcgttt gatatactca aaacgtgtga
    48361 tatcatcatt tggccccagg atatcattta caaactcacg caaagctcct ggacgctgtg
    48421 ggaaattgac cacaaagtaa tgtttgatac catcataaat caaggcacgc tcttccattt
    48481 ctggcatacg gttgatatca ttatttcctc cagaaatgat acaacaaatg gttttcccct
    48541 taatatattc agctaaaacc tctaaagagg cgatactagc cgctccagca ggttctgcga
    48601 ctatcccttg cttagagtaa aggtcaatca aggtttcaga aatcaatccc tcatcgacac
    48661 ctaccaaagt ttgaatatgt tgacgagttg cttcataggt caactgacct accttttgca
    48721 cagcaatccc atccgcaaat ttatcaattt ccttgagttt gactggacct ccagcctcaa
    48781 aggcagcttt catggaacgc gctccattcg cctctactcc gataacctca atctctggac
    48841 ttgtttcctt gatataggta gaaaccccgg caatgagacc gccaccacca acaggaacca
    48901 agacagcatc aaaatcaatc gattcttttc gagcttcttc taaaatctca taagcaactg
    48961 ttccttgacc tgcttgaaca tgagcatcat caaaaggatc aataaaggta cgattttcag
    49021 agactgtaaa ttcttgagct gctttggctg aggcatcaaa ggtatctcca actagtttaa
    49081 tagttacaaa atccccacca aaaaagcgaa cctgaccaat cttttgttgt ggcgtagtaa
    49141 taggcataaa gatagtagca ggaattttca tttcattaca agtataggct actccctgcg
    49201 catgatttcc cgcagaagcg cagactaccc cacgttcacg ttcttccttg ctgagctggg
    49261 aaatggcata ataggcacca cgaattttaa aggagcgaac acgctgggca ttttcttttt
    49321 tcaaataaat cttagcacca tacttctccg ataaataatg atcgtaatcc agtggagtat
    49381 tcacaaccac accgttcaag accttgtgag ccttgattat atcttttgaa cttaacatat
    49441 aaaacctctt tttctataaa aaacagtcac taatgactgt tttttagtta ttcatctccg
    49501 aaaacttcag taacactttc atggtattta tgagccatac gaatcgaaaa ctctttagga
    49561 agttcataac gatttgtgga aatccaatca tataaccatt ctaccaaact ttcttcacta
    49621 tcattacgat ggaagataaa atagtttaaa atttctttat attctacatc attcaaatcc
    49681 aacgtgtcta caaattgact acgaggaaca aaattagaat ctaattttct tagttgatct
    49741 gtcaattctc ccaattgtaa atccaactga aaaaatagtt tttgcagttg cctatcagtt
    49801 tcatcacatc ctgtcttgat agaaaacaaa ttggtaatat tcatatgatt tcaaccccta
    49861 aataagtaca tctaatatcc cacgaatagc tgaagctaaa gttttcgcag tccagtcatt
    49921 taaacccgat tctttcaatc cagatgcaat aatttgctct atttgatata aaccgccatc
    49981 tatcgtctca tttattctgc gaagaggacc ttcaatatag gataaagctt ctccgaatct
    50041 aacagctgat ttaggtccta atgatttacc aactatattt gttaatgttt tttatttctc
    50101 aaaatccatt tcgctatata acgagcagat ttagtcgcac cagctctctc aaacggagaa
    50161 tgaatttcaa gaccttcttc tctagctatt tgtgccaatt tgaagaattg ttcaaaggtc
    50221 atatgcaacc taccatcttc aaaattagca tcatcataaa tgttaattac agcattttca
    50281 tcatacgacc aatctgcttt attttggtct gctagcacta ttaccgacgg tgtaattaca
    50341 ttatacaact agaaccaata ataacgatgc aatttttctc ataatctttt tcataaaatc
    50401 atctccagcg ctatatattt ctaattagtt atagattttg aatgcatcat cgtcgttttt
    50461 accaacaaat ggcattgctt tacgcaattc tgcaccaact ttttcaattt caaggttagc
    50521 tgcttgttca cggtaagcag tcaattttgg acgtccagct ttatagtcat ttacaaagtc
    50581 atttgcaaat ttaccatttt ggatgtctgc caagacagcc ttcatatttt ctttaacttg
    50641 ttcagtgatt acacgtgaac ctgatacata gtcaccgtat tcagcagtgt ttgaaataga
    50701 ttgacgcatt ttcttgaatc caccttcgta gatcaagtca acgatcaatt tcatttcgtg
    50761 aagaacttca aagtaagcca attctggagc gtaacctgct tctgtcaaga cttcgaaacc
    50821 tgcttcgata agggcagtca aaccaccaca aagtacagct tgttcaccaa acaaatcttc
    50881 ttcagtttct tctttgtaag ttgtttcaag aagacctaca cgagccgctc caacaccttt
    50941 acaccagtcc atagcaatgt ttttagcatt tcctgttgca tcttggtata ctgcataaag
    51001 agctggaaca ccaaatcctt cttcgtaagt acgacgtacc aagtgtcccg gtcctttagg
    51061 agcacacatg aagacatcta catccgcagg aactttgata aattcaaagt ggatgttgaa
    51121 accatgggca aatccaactg cgtttccagc ttccaagttt ggagcgattt ctgcttcgta
    51181 caattcttgt tgaatttcgt ctggcgccaa gatcatgata acatcagcca acttagtagc
    51241 ttctactact gtgtaagtat caaatccatc ttcttttgct ttatcaaaag atttacctgg
    51301 acgtacaccg ataataacgt cacgacctga atcacgcaag ttttgagcat gcgcatgtcc
    51361 ttgtgaacca taaccgataa cggcgatttt tttaccgtca agtgctgcta ctttaacatc
    51421 tttttcatat tccatttgaa ctgtcatagc ttttctctct tttctattat ttattgcctt
    51481 ttaggctggt ttaataaatt taagttggat ttttaatcgc gggtaaatcc agttgcaccc
    51541 gttcgagcaa tattgcgaat accgtatggg cgaatgactc gcaatagggc ttcgctcttt
    51601 tctgcatttc ccgtcatctg aatggtaatc gagcttggcg ctacgtctac cactgttgca
    51661 cggaaaggtt gaataatcgc taaaatctca gctctcttct cagctggcgc tgacatctta
    51721 accaaaatca cctcgcgctc caaatgaggc ttgtctgtaa tatctcgaat gcgaatcaca
    51781 tcaatctgac gattgagctg tttgatgatt tgctccactt catcatgaga agcaacatca
    51841 ataataatag tgatacgcga tacattcgga tcttctgttg ctccaacaga gatgctttca
    51901 atattaacct gacgacgaga taggacacct gtaaagcgat tgaggactcc tgaacgattt
    51961 tgtagttttg ctgttaacat tctacgcatg gaactgcacc cccaacatct catgattact
    52021 cttaccagcc ggtaccattg gtaacacctg ttccttacga gaaatatcta cctcaattag
    52081 cataggaaca tcctcagtga tgacttcaag gtcttgagcc aaggtctcag gattgtcaaa
    52141 cttatagttt ttaataccat aagcctgcgc catcaattgg aaatcaggaa gggtatcaaa
    52201 gaccgactct gatgttctgc cttcatagaa ggattcctgc cactggcgaa ccattccaag
    52261 tgaatgattg ttcagcataa ccaccttgat tggcaccttg taaatattca aaatagccaa
    52321 ctcctggttg gtcatttgga aaccaccatc cccaacaaac aagactactt ccttatctgg
    52381 gttagcaatt ttagcaccga ttgctgctgg aattccaaag cccattgttc ccaaaccacc
    52441 tgaagtcact aactgacg
//
LOCUS       DBMVGT010000006        50679 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.006, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000006 DBMVGT010000000
VERSION     DBMVGT010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 50679)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 50679)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..50679
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.006"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(61..1332)
                     /locus_tag="AC0DU4_000385"
     CDS             complement(61..1332)
                     /locus_tag="AC0DU4_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HIN4236403.1"
                     /translation="MKKQSKYKEVVSYLKNGIESERFPTGSRLPSIRQLSLDFHCSKD
                     TIQRALLELRHEQYLYAKPQSGYYVLEQGQHQDLEIEVTDEHASAYDDFRLCVNETLI
                     GRENYLFNYYDNQEGLEDLRQSIHKLLFEQALYCKANQLVLTSGTQQALFILSQISFP
                     RQAKEILVEQPTYHRMNRLLIAQGLDYQTIERGIDGIDLEELEGHFKTGKIKFFYTIP
                     RFHYPLGHSYSEQDKRSILNLAAKYDVYIVEDDYLGDLDSKKGQTFHYLDTEEHVIYI
                     KSFSTSLFPALRITALILPNAIKEAFVAYKNILDYDSNLIMQKALSLYIDSQLFEKNR
                     LARLTNHESYQKQIEERITKTPCPLPHYPLHDGLLLDLRQYPKIASLKHSQLGLDFFE
                     EAYLSTCPYQFAKVSLDNLENVLNYLKAELE"
     gene            1474..2205
                     /gene="budA"
                     /locus_tag="AC0DU4_000386"
     CDS             1474..2205
                     /gene="budA"
                     /locus_tag="AC0DU4_000386"
                     /EC_number="4.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047605 - acetolactate decarboxylase
                     activity [Evidence IEA];
                     GO_process: GO:0045151 - acetoin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate decarboxylase"
                     /protein_id="HIN4236404.1"
                     /translation="MDKNVQEPVKLFQYNTLGALMAGLYGGTMTVGELLEHGDLGLGT
                     LDSIDGELIVLDGKAYQAKGSGDQPEIVEVSPDALIPYAAVVPHQAEVIFRQRFEMTD
                     KELKERIESYYDGENLFRSIKIRGEFSHMHVRMIPKSTPDTKFADVATHQPEYSRDNV
                     AGTIVGFWTPEIFHGVSVAGYHLHFISDDLTFGGHVMDFVIKEGIIEVGAVDQLDQRF
                     PVQDRQYLFAKFNVDEMKKDIEKAE"
     gene            2215..2967
                     /locus_tag="AC0DU4_000387"
     CDS             2215..2967
                     /locus_tag="AC0DU4_000387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhfC family intramembrane metalloprotease"
                     /protein_id="HIN4236405.1"
                     /translation="MTIHIIITMLLLLAFLIGSIWFAKKKYQINLAVLGLGAVAFFVS
                     SQILEKLVHILILHPQKDGSIALLQDHPLIYIIYGLAMAAFFEETARLVFFKWLEKKR
                     SLEKADALAYGLGHGGLELIFLGLISLLNLYIVLSAVQTQNPQVMQLLSENMLKTIQS
                     LSVWQIYLLGFERILALGFQLLLTVWVYQAVRQKKWIYLLAAYGLHAFFDLAPSLFQV
                     GWLTNPVLVEVILALELVLVAYGTKEIFCKKS"
     gene            3079..4029
                     /gene="murB"
                     /locus_tag="AC0DU4_000388"
     CDS             3079..4029
                     /gene="murB"
                     /locus_tag="AC0DU4_000388"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000116191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008762 - UDP-N-acetylmuramate
                     dehydrogenase activity [Evidence IEA];
                     GO_function: GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HIN4236406.1"
                     /translation="MSVREKMLEILEGIDIRFKEPLHSYSYTKVGGEADYLVFPRNRF
                     ELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGA
                     NLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEI
                     ETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEY
                     PSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQ
                     SVIEKVKEHSGITLEREVRILGESLSVAKMYAGGFTPCKR"
     gene            4088..5245
                     /locus_tag="AC0DU4_000389"
     CDS             4088..5245
                     /locus_tag="AC0DU4_000389"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018372333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236407.1"
                     /translation="MKKPIIEFKNVSKVFEDSNTKVLKDINFELEEGKFYTLLGASGS
                     GKSTILNIIAGLLDATTGDIMLDGVRINDIPTNKRDVHTVFQSYALFPHMNVFENVAF
                     PLRLRKIDKKEIEQRVAEVLKMVQLEGYEKRSIRKLSGGQRQRVAIARAIINQPRVVL
                     LDEPLSALDLKLRTDMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNDGEIVQ
                     SGTPVDIYDEPINHFVATFIGESNILPGTMIEDYLVEFNGKRFEAVDGGMKPNEPVEV
                     VIRPEDLRITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMIHSTRKAIVGEEIG
                     LDFEPEDIHIMRLNETEEEFDARIEEYVEIEEQEAGLINAIEEERDEENKL"
     gene            5226..6032
                     /locus_tag="AC0DU4_000390"
     CDS             5226..6032
                     /locus_tag="AC0DU4_000390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236408.1"
                     /translation="MKKTSSKLFVVPYMLWIALFVLAPLVLIFGQSFFNIEGQFSLEN
                     YKSYFASQNLTYLKMSFNSVLYAGIVTFVTLLISYPTALFLTRLKHRQLWLMLIILPT
                     WINLLLKAYAFIGIFGQNGSINQFLEFIGIGSQQLLFTDFSFIFVASYIELPFMILPI
                     FNVLDDMDNNLINASYDLGATKWETFRHVIFPLSMNGVRSGVQSVFIPSLSLFMLTRL
                     IGGNRVITLGTAIEQNFLTNDNYGMGSTIGVILILTMFITMWVTKERRER"
     gene            6029..6802
                     /locus_tag="AC0DU4_000391"
     CDS             6029..6802
                     /locus_tag="AC0DU4_000391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236409.1"
                     /translation="MKKFANLYLGLVFLVLYLPIFYLIGYAFNAGDDMNSFTGFSWTH
                     FETMFGDGRLMLILAQTFFLAFLSALIATIIGTFGAIYIYQSRKKYQEAFLSLNNILM
                     VAPDVMIGASFLILFTQLKFSLGFLTVLSSHVAFSIPIVVLMVLPRLKEMNGDMIHAA
                     YDLGASQFQMFKEIMLPYLTPSIIAGYFMAFTYSLDDFAVTFFVTGNGFSTLSVEIYS
                     RARKGISLEINALSALVFLFSIILVVGYYFISREKEEQA"
     gene            6799..7869
                     /locus_tag="AC0DU4_000392"
     CDS             6799..7869
                     /locus_tag="AC0DU4_000392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4236410.1"
                     /translation="MKKIYSFLAGIAAIILVLWGIATHLDSKINSRDSQKLVIYNWGD
                     YIDPELLTQFTEETGIQVQYEAFDSNEAMYTKIKQGGTTYDIAIPSEYMINKMKDEDL
                     LVPLDYSKIEGIENIGPEFLNQSFDPGNKFSIPYFWGTLGIVYNETMVDEAPEHWDDL
                     WKLEYKNSIMLFDGAREVLGLGLNSLGYSLNSKDPQQLEETVDKLYKLTPNIKAIVAD
                     EMKGYMIQNNVAIGVTFSGEASQMLEKNENLRYVVPTEASNLWFDNMVIPKTVKNQDS
                     AYAFINFMLKPENALQNAEYVGYSTPNLPAKELLPEETKEDKAFYPDVETMKHLEVYE
                     KFDHKWTGKYSDLFLQFKMYRK"
     gene            8130..8369
                     /locus_tag="AC0DU4_000393"
     CDS             8130..8369
                     /locus_tag="AC0DU4_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000784186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236411.1"
                     /translation="MKMSTFFKKSFWPTFMIVNQTAILFHLNDGLDRQYLTTESIYWV
                     IGTFIFGNILVAVFSNMKIWDKKKNGSKKKYILKK"
     gene            8644..9129
                     /locus_tag="AC0DU4_000394"
     CDS             8644..9129
                     /locus_tag="AC0DU4_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000847073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LURP-one-related/scramblase family protein"
                     /protein_id="HIN4236412.1"
                     /translation="MKTFLVKQKFRLGGERFAIKDDRGEIAYQVEGSFFKIPKTFTIY
                     DAAGEQVSQISKEILTLLPRFEIQLRDGSSFVIRKKLTFWRDKYEFDNLGLRIEGNIW
                     DLNFKLLDDRDQLIAEIKKELFHLTSTYTVTVLEDAYADLVISLCVAIDYVEMLESQS
                     H"
     gene            9151..11769
                     /gene="alaS"
                     /locus_tag="AC0DU4_000395"
     CDS             9151..11769
                     /gene="alaS"
                     /locus_tag="AC0DU4_000395"
                     /EC_number="6.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004813 - alanine-tRNA ligase activity
                     [Evidence IEA];
                     GO_process: GO:0006419 - alanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
                     /protein_id="HIN4236413.1"
                     /translation="MKQLSSAQVRQMWLDFWATKGHSVEPSVSLVPVNDPTLLWINSG
                     VATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRD
                     EAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEI
                     GAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRS
                     EYKELPHKNIDTGAGLERLVAVIQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMS
                     FKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTV
                     GKIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQ
                     DVFKLYDTYGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNE
                     TLQNITVESVFNYNTSQLSSKLVAIVADNAEVGAVSEGTASLIFAETSFYAEMGGQVA
                     DYGQILDESGKIVATVTNVQKAPNGQALHTVEVLAPLALNQEYTLAIDSNRRHRVMKN
                     HTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIW
                     EALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVDNTSEIGL
                     FKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAIAATLKAPQVKEVPHKVEGLQ
                     EQLRQLQKENAELKEKAAAAAAGDIFKDVKEVNGHRYIASQVSVSDAGALRTFADNWK
                     QKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGS
                     NQAKIQELLDAVAGKL"
     gene            complement(11859..13313)
                     /locus_tag="AC0DU4_000396"
     CDS             complement(11859..13313)
                     /locus_tag="AC0DU4_000396"
                     /EC_number="3.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004556 - alpha-amylase activity [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-amylase"
                     /protein_id="HIN4236414.1"
                     /translation="MQNQTLMQYFEWYLPHDGQHWTRLAENAPHLAHLGISHVWMPPA
                     FKATNEKDVGYGVYDLFDLGEFNQKGTVRTKYGFKEDYLQAIQALKEQGIQPMADVVL
                     NHKAAADNREAFQVIEVDPVDRTVELGEPFTINGWTSFTFDGRQDTYNGFHWHWYHFT
                     GTDYDAKRSKSGIYLIQGDNKGWANKELVDNENGNYDYLMYADLDFKHPEVIQNIYDW
                     ADWFMETTGVAGFRLDAVKHIDSFFMRNFIRDMKEKYGDDFYVFGEFWNPDKEANLDY
                     LEKTEEHFDLVDVRLHQNLFEASQAGANYDLRGIFTDSLVELKPDKAVTFVDNHDTQR
                     GQALESTVEEWFKPAAYALILLRQDGLPCVFYGDYYGISGQYAQEDFKEILDRLLAIR
                     KDLAYGEQNDYFDHANCIGWVRSGAENQSPIAVLISNDQENSKSMFVGQEWTNQTFVD
                     LLGNHQGQVTIDEEGYGQFPVSARSVSVWAVNTI"
     gene            13492..14241
                     /locus_tag="AC0DU4_000397"
     CDS             13492..14241
                     /locus_tag="AC0DU4_000397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236415.1"
                     /translation="MIEFQNVSKLYGDKEALSNLNLQIENGEIMGLIGHNGAGKSTTI
                     KSLVSIISPSSGRILVDGQELSENRLAIKRKIGYVADSPDLFLRLTANEFWELIASSY
                     DLTSSDLETSLARLLNVFDFAENRYQVIETLSHGMRQKVFVIGALLSAPDIWVLDEPL
                     TGLDPQAAFDLKQMMKEHAQKGKTVLFSTHVLEVAEQVCDRIAILKKGHLIYCGSVEN
                     LRKDHPDQFLESIYLSLAGRKEEVADASQGH"
     gene            14222..15856
                     /locus_tag="AC0DU4_000398"
     CDS             14222..15856
                     /locus_tag="AC0DU4_000398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236416.1"
                     /translation="MRLKVIKKLVDINILYSSQEANLANLRKKQAKNPGKKVNVSARV
                     LSSYIFSSLLMLICFSNIAIHFPFEEMPIYFSSMVAILLVLAFSTSFTAFYNVFYESK
                     DLASYRPYAFKESEIIMAKGLSVLLPALTGIVPILAYFLALYISLAPSLWLGLPLMLL
                     SLTLLFVSVTLVTVVAVHFLAQTRVFRKYQSIFSNVMIGIGVLIPLIFIFFLQSTFGS
                     IVDKVRDIPFLLYPLHIFYKIAVEPFSTEALVGLLAWIGLTLFLLYLTKKKVLPRFYD
                     VILLNSEEKVKKERRSKERISTTKKGFFRMVLRYHLTLLGQGTGVITVLFTSAFLPYL
                     MMISLISKIRDSQIVPDIHPPYWLPLFFVGVFIAVVNNNITSLHSIALSLERENVDFL
                     KSLPFDFARYVKVKFWIIFAVQSFLPVLTLLGLSLYLGLPILSMIYLLVVWIIASVIL
                     SCHHYFKDVKNLSTNWSSITDLVNRSNGIVAIVLLFIYSAILMALVIGSIFLVQSLSP
                     ILAINLGVGALIVLLALAIFGYHYYLSRILAEIEKR"
     gene            16541..17704
                     /locus_tag="AC0DU4_000399"
     CDS             16541..17704
                     /locus_tag="AC0DU4_000399"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent rRNA methyltransferase"
                     /protein_id="HIN4236417.1"
                     /translation="MNRIRVSKRVEKKLAKGLVLLEASDLENVNLKDQEVEVQGQEGN
                     FLGTAYLSQQNKGLGWFVSKDKVAFNQAFFETLFRKAKEKRNAYYQDDLTTAFRLFNQ
                     EGDGFGGLTVDLYGDYAVFSWYNSYVYQIRQTISEAFRQVFPEVLGAYEKIRFKGLDY
                     ESAHVYGQEAPDFFTVLENGVLYQVFMNDGLMTGIFLDQHEVRGSLVDGLAMGKSLLN
                     MFSYTAAFSVAAAMGGASQTTSVDLAKRSRELSQAHFQANGLSTDEHRFIVMDVFEYF
                     KYAKRKDLTYDVIVLDPPSFARNKKQTFSVAKDYHKLISQSLEILNPGGIIIASTNAA
                     NVSRQKFTEQIDKGFAGRSYQILNKYGLPADFAYNKKDESSNYLKVISMKVSK"
     gene            17701..18378
                     /gene="aroD"
                     /locus_tag="AC0DU4_000400"
     CDS             17701..18378
                     /gene="aroD"
                     /locus_tag="AC0DU4_000400"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003855 - 3-dehydroquinate dehydratase
                     activity [Evidence IEA];
                     GO_process: GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HIN4236418.1"
                     /translation="MKLIVSVMPRSLEEAQALDATRYLDADIIEWRADYLPKEAILQV
                     APAIFEKFAGRELVFTLRTRSEGGEIDLSPEEYIHLIKEVAQLYQPDYIDFEYYSYKD
                     VFEEMLDFPNLVLSYHNFQETPENMMEILSELTILNPKLVKVAVMAHTEQDVLDLMNY
                     TRGFKTLNPEQEYVTISMGKVGKVSRITADVTGSSWSFASLDEVSAPGQISLASMKKI
                     REILDEA"
     gene            18368..19222
                     /locus_tag="AC0DU4_000401"
     CDS             18368..19222
                     /locus_tag="AC0DU4_000401"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HIN4236419.1"
                     /translation="MKLDGYTRLAAVVANPIKHSISPFIHNRAFEATATNGAYVAWEI
                     EASDLAETVANIRRYQMFGINLSMPYKEQVIPYLDELSDEARLIGAVNTVVNENGNLI
                     GYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEK
                     TRPYLDKLQEQTGFKVDLCALEYVSELQARIAESDLLVNATSVGMDGQSSPVPENIVL
                     PETLLVADIIYQPFETPFLKWARSQGNPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIW
                     QSLTEKYQ"
     gene            19241..20308
                     /gene="aroB"
                     /locus_tag="AC0DU4_000402"
     CDS             19241..20308
                     /gene="aroB"
                     /locus_tag="AC0DU4_000402"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000702157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003856 - 3-dehydroquinate synthase
                     activity [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HIN4236420.1"
                     /translation="MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNH
                     VASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVAL
                     GGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQP
                     DGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLI
                     EHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISK
                     IAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVP
                     ELGSAIIHPVSLEEMKDYLVK"
     gene            20318..21484
                     /gene="aroC"
                     /locus_tag="AC0DU4_000403"
     CDS             20318..21484
                     /gene="aroC"
                     /locus_tag="AC0DU4_000403"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004107 - chorismate synthase activity
                     [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HIN4236421.1"
                     /translation="MRYLTAGESHGPRLTAIIDGIPAGLPLTAEDINEDLRRRQGGYG
                     RGGRMKIENDQVVFTSGVRHGKTTGAPITMDVINKDHQKWLDIMSAEDIEDRLKSKRK
                     ITHPRPGHADLVGGIKYRFDDLRNSLERSSARETTMRVAVGAVAKRLLAELDMEIANH
                     VVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQIKRDGDTIGGVV
                     ETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGVEFGLGFEAGYRKGSQVMDEI
                     LWSKEDGYTRRTNNLGGFEGGMTNGQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKAT
                     VERSDPTALPAAGMVMEAVVATVLAQEILEKFSSDNLEELKEAVAKHRDYTKNY"
     gene            21494..22597
                     /locus_tag="AC0DU4_000404"
     CDS             21494..22597
                     /locus_tag="AC0DU4_000404"
                     /EC_number="1.3.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydrogenase"
                     /protein_id="HIN4236422.1"
                     /translation="MAKTIYIAGLGLIGASMALGIKRDHPDYEILGYNRSQASRDIAL
                     KEGMIDRATDDFASFAPLADVIILSLPIKQTIAFIKELANLDLREGVIISDAGSTKST
                     IVDAAEQYLAGKSVRFVGAHPMAGSHKTGAASADVNLFENAYYIFTPSSLTSQDTLKE
                     MKDLLSGLHARFIEIDAKEHDRVTSQISHFPHILASSLMEQTAVYAQEHEMARRFAAG
                     GFRDMTRIAESEPGMWTSILLSNSEIILDRIEDFKERLEAIGQAISKGDEEQIWNFFN
                     QAREQRQTMEIHKRGGVDSSYDLYVDVPDEEDVILRILELLRGTSLVNIHINEENRED
                     IHGILQISFKNAQDLERAEHLITENTDYTVVIK"
     gene            22608..22946
                     /locus_tag="AC0DU4_000405"
     CDS             22608..22946
                     /locus_tag="AC0DU4_000405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbF/YmcA family competence regulator"
                     /protein_id="HIN4236423.1"
                     /translation="MSNIYDSANELSRGLRGLPEYKAVKAAKDAIAADAEASKIFTDY
                     LAFQEEIQKLAQTGQMPDASFQAKMEGFGKQIQGNSLLSEFFTKQQQLAIYLSDIEKI
                     VFEPVSELLK"
     gene            23038..24321
                     /gene="aroA"
                     /locus_tag="AC0DU4_000406"
     CDS             23038..24321
                     /gene="aroA"
                     /locus_tag="AC0DU4_000406"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HIN4236424.1"
                     /translation="MKLKTNIRHLHGSIRVPGDKSISHRSIIFGSLAEGETKVYDILR
                     GEDVLSTMQVFRDLGVEIEDKDGVITIQGVGMAGLKAPQNALNMGNSGTSIRLISGVL
                     AGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLSPIHY
                     ELPIASAQVKSALMFAALQAKGESVIIEKEYTRNHTEDMLQQFGGHLSVDGKKITVQG
                     PQKLTGQKVVVPGDISSAAFWLVAGLIAPNSRLVLQNVGINETRTGIIDVIRAMGGKL
                     EITEIDPVAKSATLIVESSDLKGTEICGALIPRLIDELPIIALLATQAQGVTVIKDAE
                     ELKVKETDRIQVVADALNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAI
                     AALLVADGEVELDRAEAINTSYPSFFDDLESLIHG"
     gene            24314..24790
                     /locus_tag="AC0DU4_000407"
     CDS             24314..24790
                     /locus_tag="AC0DU4_000407"
                     /EC_number="2.7.1.71"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0004765 - shikimate kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HIN4236425.1"
                     /translation="MAKVLLGFMGAGKSTIARGLDPNYLDMDALIEKRLGMSIANFFA
                     EKGESAFRQVESEVLADLLQTDQVVSTGGGVVISQRNRDLLKTNTDNIYLKADFETLY
                     LRIVADKDNQRPLFLNNSKEELVAIFQERQAWYEEVASRVLDVTKLSPEEIIEELR"
     gene            24787..25635
                     /gene="pheA"
                     /locus_tag="AC0DU4_000408"
     CDS             24787..25635
                     /gene="pheA"
                     /locus_tag="AC0DU4_000408"
                     /EC_number="4.2.1.51"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004664 - prephenate dehydratase activity
                     [Evidence IEA];
                     GO_process: GO:0009094 - L-phenylalanine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HIN4236426.1"
                     /translation="MKIAYLGPKGSFSHHVVQTAFPHEELQAFANITDVIKAYEQGLV
                     DYSVVPVENSIEGSVHETLDYLFHQAHIQAVAEIVQPIHQQLMVVPGHTKIEKIFSHP
                     QALAQGKKFIDEQYPEAQIEVTASTAYAARFISEHPDQPFAAVAPRSSAEEYGLELIA
                     EDIQEMEANFTRFWVLGAEKPSIPLQAQTEKMSLALTLPDNLPGALYKALSTFAWRGI
                     DLTKIESRPLKTALGEYFFIIDVDYTDKDLVHFAQKELEAIGIQYKILGAYPIYPISD
                     HGKERR"
     gene            25632..26906
                     /gene="psr"
                     /locus_tag="AC0DU4_000409"
     CDS             25632..26906
                     /gene="psr"
                     /locus_tag="AC0DU4_000409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyisoprenyl-teichoic acid--peptidoglycan
                     teichoic acid transferase Psr"
                     /protein_id="HIN4236427.1"
                     /translation="MSKENPLSHHEQLRYDYLLKNIHYLNEREKNEFAYLQEKLTLAR
                     RNSSSSLEQEREEQVDLPSYANRSRSQSKSQALSSPPKKKRRKLRLKRIFMVIFSLLV
                     CVALAMVFMFLRGYQDASAKKTADARAAQVEVFNGQDTRDGVNILIMGTDGRIGQNSV
                     ETRTDSIMVLNVGGSDKKMKLVSFMRDNLVYIDGYSQVINGRKQTDNKLNVAYELGEQ
                     EGQKGAEMVRQVLKDNFDLDIKYYALVDFQAFATAIDTLFPDGVTIDAQFSTLNGRPL
                     TEATVGDDLYATETESPTQTIKVGKQQMNGSTLLNYARFRDDDEADYGRTKRQQQVLT
                     AILEQIKDPTKLFTGSEALGKVFAMTSTNVPYTFLLTNGLSVLDGAKNGIEKLTIPEL
                     GDWVDAYDVYGGLGLLVDQNKYQTKLAQMGLR"
     gene            27185..28030
                     /locus_tag="AC0DU4_000410"
     CDS             27185..28030
                     /locus_tag="AC0DU4_000410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LicD family protein"
                     /protein_id="HIN4236428.1"
                     /translation="MNNMTDLKAIQARSLEMAEYFVAFCKEHDLLCYLCGGGAIGTLR
                     NKGFIPWDDDLDFFMPRKDYEKLAELWPRYADERYFLSKSYKDFVDRNLFITIRDKET
                     TCIKPYQQDLDLPHGLALDVLPLDYYPKDPAERKKQVRWALIYSLFCAQTIPEKHGAL
                     MKWGSRILLGLTPKSLRYRIWKKAEKEMTKYDLADCDGITELCSGPGYMRNKYPITSF
                     EDNLFLPFEGTEMPIPIGYDVYLRTAFGDYMTPPPADKQVPHHDAVIADMDKSYTEYK
                     GEYGG"
     gene            28020..29123
                     /locus_tag="AC0DU4_000411"
     CDS             28020..29123
                     /locus_tag="AC0DU4_000411"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000225894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HIN4236429.1"
                     /translation="MVAKKKILFFMWSFSLGGGAEKILSTIVSNLDPEKYDIDILEME
                     HFDKGYESVPKHVRILKSLQDYRQTRWLRAFLWRMRIYFPRLARRLLVKDDYDVEVSF
                     TIMNPPLLFSKRREVKKISWIHGSIEELLKDSSKRESHRSQLDAANTIVGISKKTSNS
                     IKEVYPDYASKLQTIYNGYDFQTILEKSQEKIDIEIAPQSICTIGRIEENKGSDRVVE
                     VIRLLHQEGKNYHLYFIGAGDMEEELKKRVKEYGIEDYVHFLGYQKNPYQYLSQTKVL
                     LSMSKQEGFPGVYVEALSLGLPFISTDVGGAEELSQEGRFGQIIESNQEAAQAITNYM
                     TSASNFDVDEASQFIQQFTITKQIEQVEKLLEE"
     gene            29125..30111
                     /locus_tag="AC0DU4_000412"
     CDS             29125..30111
                     /locus_tag="AC0DU4_000412"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000446977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HIN4236430.1"
                     /translation="METALISVIVPVYNVAQYLEKSIASIQKQIYQNLEIILVDDGAT
                     DESGRLCDSIAEQDDRVSVLHKKNEGLSQARNDGMKQAHGDYLIFIDSDDYIHPEMIQ
                     SLYEQLVQEDADVSSCGVMNVYANDESPQSANQDDYFVCDSQTFLKEYLIGEKIPGTI
                     CNKLIKRQIATALSFPKGLIYEDAYYHFDLIKLAKKYVVNTKPYYYYFHRGDSITTKP
                     YAEKDLAYIDIYQKFYNEVVKNYPDLKEVAFFRLAYAHFFILDKMLLDDQYKQFEAYS
                     QIHRFLKGHAFAISRNPIFRKGRRISALALFINISLYRFLLLKNIEKSKKLH"
     gene            30127..31560
                     /locus_tag="AC0DU4_000413"
     CDS             30127..31560
                     /locus_tag="AC0DU4_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen polysaccharide polymerase Wzy family
                     protein"
                     /protein_id="HIN4236431.1"
                     /translation="MIDGKRLLFSLTIVSYALTLVSGIVYLFNNNNVSLLSTLLFLLV
                     SSLIACWNDIKYYLIHFIFYLTIFVFLVSRPTIDYFRDGALDTYHPIAYRFAFIVVMV
                     SILGLTTGGILARYFIARKKIKVANIGNSLKEVYIKRLRFVSLGVFLLTYPFYFIRLF
                     ERLLYRLQTSYYAYYANFESKLPYFTYILSTFTVYAMCMYLATKPKKLQATAVLVSFI
                     AANTIHLAIGTRNPFILSILFAFVYYFMREQTEKGKWIGFKEKLAIFVGSPILMLAMG
                     VLNYVRDNVQVSHTGFWDILLDFIYKQGTSFGVLARGFLFNSSLPYRDFRNFTFGPVL
                     DYFARGSLGAIFGGKAFEHTTNSVELAIDSNSYAHNLSYLVLNKEYLKGHGIGSSYIM
                     ELYTDYGMIGVFLLSFLLGVLFIAMLQVAYRSRTILFALSLLILNNLFFMPRSSFSES
                     FFNLFTMQFWGIVLVIIFIAKMLTKEN"
     gene            31589..32623
                     /locus_tag="AC0DU4_000414"
     CDS             31589..32623
                     /locus_tag="AC0DU4_000414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HIN4236432.1"
                     /translation="MFEHYSVADLFANLYKKRKANILALIALFALIAVPFTIKAVRNK
                     NTVKDTTSYSTYLIYKITPPKESAKTILNHQIGGYSDFYGKLIDGNLNGAYLFNDVEP
                     SELKKIASELDTTETTLKNSTNDYWWKKLTVYYMIDDAGVGVKILTSSKDANDLLEKK
                     IDGLIEKFKHAYANVKIEKLETINSKELNANGETALGLNVKNLILRLVVIGVVCVILV
                     VMGNVLVYLFNPTINRVGDFSQYQIDFVTEITTIANLADVLSYKNTGQELTIVSSNKA
                     ILDKLKQSQEALKGMHFVDLQDVSSLLERDTVLLVEEYGVTRYKKFEQSLQILRNLNR
                     SILGVATFKL"
     gene            32765..33502
                     /gene="mecA"
                     /locus_tag="AC0DU4_000415"
     CDS             32765..33502
                     /gene="mecA"
                     /locus_tag="AC0DU4_000415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adaptor protein MecA"
                     /protein_id="HIN4236433.1"
                     /translation="MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAI
                     LDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMS
                     PDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
                     KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDS
                     DISRSVLQEYGQVLMSHDAVLNLQKIG"
     gene            33653..34939
                     /locus_tag="AC0DU4_000416"
     CDS             33653..34939
                     /locus_tag="AC0DU4_000416"
                     /EC_number="1.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004412 - homoserine dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HIN4236434.1"
                     /translation="MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVK
                     DEDEKNRLLAAGNDFNFVTNVDDILSDQDITIVVELMGRIEPAKTFITRALEAGKHVV
                     TANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVN
                     GTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMK
                     IAFDDVVHKGIRNITPEDVAVAQELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLA
                     SVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEY
                     SRDLVLANPEDVKANYYFSILAPDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARV
                     VIITHKINKAQLENVSAELKKVSEFDLLNTFKVLGE"
     gene            34941..35810
                     /gene="thrB"
                     /locus_tag="AC0DU4_000417"
     CDS             34941..35810
                     /gene="thrB"
                     /locus_tag="AC0DU4_000417"
                     /EC_number="2.7.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000692406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004413 - homoserine kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine kinase"
                     /protein_id="HIN4236435.1"
                     /translation="MKIIVPATSANIGPGFDSVGVAVTKYLQIEVCEERDEWLIEHQI
                     GKWIPHDERNLLLKIALQIVPDLQPRRLKMTSDVPLARGLGSSSSVIVAGIELANQLG
                     QLNLSDHEKLQLATKIEGHPDNVAPAIYGNLVIASSVEGQVSAIVADFPECDFLAYIP
                     NYELRTRDSRSVLPKKLSYKEAVAASSIANVAVAALLAGDMVTAGQAIEGDLFHERYR
                     QDLVREFAMIKQVTKENGAYATYLSGAGPTVMVLASHDKMPTIKAELEKQPFKGKLHD
                     LRVDTQGVRVEAK"
     gene            36060..36998
                     /gene="msrB"
                     /locus_tag="AC0DU4_000418"
     CDS             36060..36998
                     /gene="msrB"
                     /locus_tag="AC0DU4_000418"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA];
                     GO_process: GO:0006979 - response to oxidative stress
                     [Evidence IEA];
                     GO_process: GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HIN4236436.1"
                     /translation="MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLI
                     KETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEAD
                     LPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
                     LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPL
                     FFAKDKFASGCGWPSFSRPISKELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPR
                     ELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK"
     gene            37056..38780
                     /locus_tag="AC0DU4_000419"
     CDS             37056..38780
                     /locus_tag="AC0DU4_000419"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236437.1"
                     /translation="MKHLLSYFKPYIKESILAPLFKLLEAVFELLVPMVIAGIVDQSL
                     PQGDQGHLWMQIGLLLIFAVIGVLVALIAQFYSAKAAVGFAKELTNDLYRHILSLPKD
                     SRDRLTTSSLVTRLTSDTYQIQTGINQFLRLFLRAPIIVFGAIFMAYRISTELTFWFL
                     VMVAILTIVIVGLSRLVNPLYSSLRKKTDQLVQETRQQLQGMRVIRAFGQEKRELQIF
                     QTLNQVYARLQEKTGFWSSLLTPLTYLIVNGTLLVIIWQGYISIQGGVLSQGALIALI
                     NYLLQILVELVKLAMLINSLNQSYISVKRIEEVFVEAPEDIHSELEQKQATRDKVLQV
                     QELTFTYPDAAQPSLRYISFDMTQGQILGIIGGTGSGKSSLVQLLLGLYPVDKGNIDL
                     YQNGRSPLNLEQWRSWIAYVPQKVELFKGTIRSNLTLGFNQEVSDQELWQALEIAQAK
                     DFVSEKEGLLDALVEAGGRNFSGGQKQRLSIARAVLRQAPFLILDDATSALDTITESK
                     LLKAIRENFPNTSLILISQRTSTLQMADQILLLEKGELLAVGKHDDLMKSSQVYCEIN
                     ASQHGKED"
     gene            38782..40533
                     /locus_tag="AC0DU4_000420"
     CDS             38782..40533
                     /locus_tag="AC0DU4_000420"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236438.1"
                     /translation="MKRQTVNQTLKRLAVDLASHPFLLFLAFLGTIAQVGLSIYLPIL
                     IGQVIDQVLVAGSSPVFWQIFLQMLLVVIGNTLVQWANPLLYNRLIFSYTRDLRERII
                     HKLHRLPIAFVDRQGSGEMVSRVTTDIEQLAAGLTMIFNQFFIGVLMILVSILAMLQI
                     HLLMTLLVLLLTPLSMVISRFIAKKSYHLFQKQTETRGIQTQLIEESLSQQTIIQSFN
                     AQTEFIQRLREAHDNYSGYSQSAIFYSSTVNPSTRFVNALIYALLAGVGAYRIMMGSA
                     LTVGRLVTFLNYVQQYTKPFNDISSVLAELQSALACVERIYGVLDSPEVAETGKEVLT
                     TSDQVKGAISFKHVSFGYHPEKILIKDLSIDIPAGSKVAIVGPTGAGKSTLINLLMRF
                     YPISSGDILLDGQSIYDYTRVSLRQQFGMVLQETWLTQGTIHDNIAFGNPEASREQVI
                     AAAKAANADFFIQQLPQGYDTKLENAGESLSVGQAQLLTIARVFLAIPKILILDEATS
                     SIDTRTEVLVQDAFAKLMKGRTSFIIAHRLSTIQDADLILVLVDGDIVEYGNHQELMD
                     RKGKYYQMQKAAAFSSE"
     gene            40880..42139
                     /locus_tag="AC0DU4_000421"
     CDS             40880..42139
                     /locus_tag="AC0DU4_000421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TRZ/ATZ family protein"
                     /protein_id="HIN4236439.1"
                     /translation="MKVFQHVNIVTCDQDFHVYLDGILAVKDSQIVYVGQDKPAFLEQ
                     AEQIIDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSNLHEWLNDYIWPAESEFTPDMTT
                     NAVKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTA
                     ETISRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAE
                     TKEESGIILKRYGKRPLAFLEELGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPI
                     SNLKLASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTAALLQKMKSGDASQF
                     PIETALKVLTIEGAKVLGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYA
                     VKSSDVDDVYIAGEQVVKQGQVLTVEL"
     misc_feature    42215..42350
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            42389..42889
                     /gene="rplJ"
                     /locus_tag="AC0DU4_000422"
     CDS             42389..42889
                     /gene="rplJ"
                     /locus_tag="AC0DU4_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001287276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HIN4236440.1"
                     /translation="MSEAIIAKKAELVDVVAEKMKAAASIVVVDARGLTVEQDTVLRR
                     ELRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNDFSK
                     NAEALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVAE
                     SKEDAA"
     gene            42965..43333
                     /gene="rplL"
                     /locus_tag="AC0DU4_000423"
     CDS             42965..43333
                     /gene="rplL"
                     /locus_tag="AC0DU4_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HIN4236441.1"
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAA
                     DAADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVAT
                     AEAEEIKAKLEEAGASVTLK"
     gene            43520..43690
                     /locus_tag="AC0DU4_000424"
     CDS             43520..43690
                     /locus_tag="AC0DU4_000424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236442.1"
                     /translation="MQKEGQSSRQFVKSHLMTIMGVDIVKATQLVDEMEQVGLIRFDE
                     FGNVGILVLEGQ"
     gene            43690..43941
                     /locus_tag="AC0DU4_000425"
                     /pseudo
     CDS             43690..43941
                     /locus_tag="AC0DU4_000425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
     gene            43952..44292
                     /locus_tag="AC0DU4_000426"
                     /pseudo
     CDS             43952..44292
                     /locus_tag="AC0DU4_000426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001134542.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            44285..44665
                     /locus_tag="AC0DU4_000427"
     CDS             44285..44665
                     /locus_tag="AC0DU4_000427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HIN4236443.1"
                     /translation="MIDLYLSKNRQRNQLLLDFFQNYGIEVSCHSVSEMTKDKLIEMM
                     SYSSDCFEFLSPNLLRFKNRDNLRLTDFVEIILKNPELTIRLPLAVSNKRVYPSLNLE
                     EARALLPRDTKQLIYMAQTHYLSN"
     gene            44678..44911
                     /locus_tag="AC0DU4_000428"
                     /pseudo
     CDS             44678..44911
                     /locus_tag="AC0DU4_000428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840775.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
     gene            44914..45491
                     /locus_tag="AC0DU4_000429"
                     /pseudo
     CDS             44914..45491
                     /locus_tag="AC0DU4_000429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000821297.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
     gene            45693..45830
                     /locus_tag="AC0DU4_000430"
     CDS             45693..45830
                     /locus_tag="AC0DU4_000430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004264816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SapB/AmfS family lantipeptide"
                     /protein_id="HIN4236444.1"
                     /translation="MAEEVLNLQLVSVQVDETDEVDGMRFSTFSTNRCGNWSAFSWEN
                     C"
     gene            46120..47523
                     /locus_tag="AC0DU4_000431"
     CDS             46120..47523
                     /locus_tag="AC0DU4_000431"
                     /inference="COORDINATES: protein motif:HMM:NF012298.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004672 - protein kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="protein kinase domain-containing protein"
                     /protein_id="HIN4236445.1"
                     /translation="MNNDEWVYQYPIGKFVERQGWKIHISSEYNSSHELLQDVAKICH
                     EMRIPFKHLSTEDKFIMRNGKLVSRGFSGKFITCYPNQNELESVLQRLESALKQYNGP
                     YILSDKRWDEAPIYLRYGVFRPSRDDEKKVVIDELIVGDEVVKDERLPVFKIPKGIVP
                     PDFLNKWLDKKDKKQGDFPFIIDNAIRFSSSGGIYNARLKEDGKKIILKEARPYTGLG
                     FDGTYSSERLASECKALKILNEWSEMPKIYWYGKIWEHTFLGIEHMKGVPLNRWVTNN
                     FPLYEVVDKTKDYLLRVSKIVEKLIDLTNKFHSENVYHQDLHLGNILVKDEDEISIID
                     WEQAVFSNDEKVVHKVAAPGFRAWRETLPSEIDWYGIRQIAHYLYMPLVTTSDLTYNY
                     VSQTRIEGKKLFESLGYTREHIDYVESLLSYLDSKCPQIENISRKKVLKPMHEIRTIE
                     SEQDIQDFIIKAFLLVN"
     gene            47712..48296
                     /locus_tag="AC0DU4_000432"
     CDS             47712..48296
                     /locus_tag="AC0DU4_000432"
                     /inference="COORDINATES: protein motif:HMM:NF012235.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4236446.1"
                     /translation="MKDVVYSITPENKLSIDFSFKSPFRVLLTGTSGSGKTTILNLIN
                     GSLKPQKGYVNLLSHGKKSSDSIPTVDQTPYIFDTTIRENVTLFQNEYFSDDQIIEVL
                     KKVNLYEELEKIDILNYQCGENGSNLSGGQKQKIALARALIRNNKVYLFDEISANLDN
                     DNSNSIHDILFNLGISFIEVSHHYDLNDKRYTDI"
     gene            48345..49085
                     /locus_tag="AC0DU4_000433"
     CDS             48345..49085
                     /locus_tag="AC0DU4_000433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000356590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236447.1"
                     /translation="MDKDYILKVKGLYHQFLLGNNKTLQVLKNVSLSASRGEFISILG
                     ISGSGKSTLLKCISSLLEPTSGEVILNGINPYKIRNAKLSSIRRNEVSFIFQAYNLIP
                     SLPVIENIALPLRLSQKKLTIKNVENLLKRMKFNAGLNDFVGTLSGGEQQKVAIARAV
                     IADSDIIFADEPTGALDSVSREVIFELLRELVGAGKCVIMVTHDIELASKTDRALILK
                     DGKIFKELHRPSGEELYKILEVQSTTEE"
     gene            49088..50407
                     /locus_tag="AC0DU4_000434"
     CDS             49088..50407
                     /locus_tag="AC0DU4_000434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000945307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236448.1"
                     /translation="MLRLVYYQFLHNKKQWLGVSPVIFVSSLVMGLAVNGVINVENNS
                     QVFVGLPDPKPIFMFPIVFGGVTLFFVLSNIINMLVEIFRDDYELLEVLGASLLQLSF
                     LVGGQIFIISSIISFIAYLCSIFVTSNYYYFLQYFFGENILPDIQFQTSAVGCIITVV
                     LISFLAFLSGCFYTFKKIRNRKSSKIRHVLSIVKRILLLAGFSVIWLLSLQQIFQDST
                     ILAKAQIIFNIVILDIVIIYQLSPFIQSCFIKLLSIIIFRNNFMFIVSKWNLLYRKPY
                     IKSISAAITGAILLISSFQMISQNILSQFQDDSDLELKVAFIVYVGAPILIVLANIIS
                     IAFLSSHQERIEIQQFEILGTSNYQMVKIKVGEAIFLTFVTSLIAFLLNIKIMALIYY
                     SLGDILIDDMNLLGLILPNFIVSIILFILIFITKSSYFIFKNAKIIS"
     gene            50541..50678
                     /locus_tag="AC0DU4_000435"
     CDS             50541..50678
                     /locus_tag="AC0DU4_000435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004264816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SapB/AmfS family lantipeptide"
                     /protein_id="HIN4236449.1"
                     /translation="MAEEVLNLQLVSVQVDETDEVDGMRFSTFSTNRCGNWSAFSWEN
                     C"
BASE COUNT        14940 a         9239 c        11180 g        15320 t
ORIGIN      
        1 atcttgaaaa agcagcaagt ctaactgaag ttgaagaata agaaaaagca gagttggatg
       61 tcattccaat tctgctttta aatagtttaa aacattttcc agattgtcta gggacacctt
      121 ggcaaattga taaggacagg tgcttaaata ggcctcttca aagaagtcca agcccagttg
      181 actgtgtttg agactggcga ttttaggata ctgtctcagg tctagcaata aaccatcgtg
      241 taggggataa tgaggaaggg gacaaggtgt tttagttatc ctttcctcga tttgtttttg
      301 gtaagattca tgattggtca agcgagccaa acgatttttt tcaaacaatt gactgtcaat
      361 atagagtgac agggcctttt gcataatgag gttgctgtcg tagtctagga tatttttgta
      421 ggccacaaat gcttctttga tagcatttgg aagaatgagt gctgtaatac gaagggcagg
      481 aaaaaggctg gtcgagaagg acttgatata aatgacatgc tcctctgtat caagatagtg
      541 gaaggtttgg cccttcttgg agtccaaatc acccagataa tcgtcctcta cgatatagac
      601 atcatacttg gcagctaagt taagaataga tcgtttgtct tgctcagaat aggaatgtcc
      661 cagaggatag tgaaatctag gaatggtgta gaaaaattta atttttcctg ttttgaagtg
      721 gccttccagc tcctccaagt caatcccatc aatgcctcgt tcaatcgttt gatagtccag
      781 cccctgtgca atcaagaggc gattcatccg atggtaggtt ggctgttcca ccaagatttc
      841 cttggcttgt ctaggaaagg atatttgaga gaggataaac aaggcttgtt gggttccaga
      901 agtcagtact agttggttag ccttgcagta gagagcttgc tcaaatagga gtttgtgaat
      961 ggactgtctt aggtcttcta atccttcttg attgtcatag tagttgaaga ggtagttttc
     1021 tcgtccaatc aaggtttcat tgacacagag tcggaaatcg tcataggcac tggcatgttc
     1081 gtcggtaacc tcgatttcta ggtcttgatg ttgcccttgt tctaatacat agtagccact
     1141 ctgaggcttg gcatagaggt attgttcgtg ccgtaattcc agcagggctc gttgaatggt
     1201 gtccttgctg cagtgaaagt caaggctcag ttgacggata gaaggcaggc gactacccgt
     1261 cggaaatcgt tcagactcga taccattttt cagataggaa acgacctctt tgtacttgct
     1321 ttgtttcttc attccagacc tcccttgatt ttgttacatt gtaccctttt ttttccttct
     1381 tggcaatgtc tagagcgttt ctctcgttca catctagggg caaatgtggt atacttagga
     1441 gtaagattta tagaataaca gacaagaaag tgaatggata agaacgtgca ggaaccagtg
     1501 aaattatttc aatacaatac tcttggagcc ttgatggctg gcctttatgg tggtactatg
     1561 acagtaggag aattgctaga acatggtgac cttggtttgg gaaccttgga ttccattgat
     1621 ggggaattga ttgtcttgga tggcaaggct tatcaggcca aagggtcagg agaccagcca
     1681 gaaattgtgg aagtgtcacc agatgccctt attccttacg ctgcagtggt accgcatcag
     1741 gcagaggtca ttttccgcca gcgctttgag atgacagaca aggaattgaa agaacgaatt
     1801 gagtcttatt atgatgggga aaatcttttc cgctctatca agattcgggg ggaattttca
     1861 catatgcatg tgcgtatgat tcctaagtca acacccgata ccaagtttgc tgatgtcgca
     1921 acccatcaac cggaatatag tcgtgacaat gttgcgggga ctattgttgg tttctggacg
     1981 cctgagattt tccatggggt cagtgtggca ggctaccatc tgcacttcat atcagatgat
     2041 ttgaccttcg gtggacatgt catggatttt gtcatcaagg aaggcattat cgaggtggga
     2101 gcagttgacc agttggacca acgtttccca gtccaagacc gtcaatactt gtttgctaag
     2161 ttcaatgttg acgagatgaa aaaagatatt gaaaaggcag aataggagaa gaaaatgacc
     2221 attcatatca ttattaccat gttgctgttg ctagcttttc tgataggaag catttggttt
     2281 gccaaaaaga aataccagat taatctagct gtcttgggct tgggtgcagt cgctttcttt
     2341 gtctcttcgc agattttgga aaaactggtg catatcttga ttttgcatcc tcaaaaagac
     2401 ggtagtattg ccctcttgca agatcatccg cttatctata ttatctatgg cctagccatg
     2461 gcagcatttt ttgaggaaac ggctcgtctt gttttcttca aatggttgga gaaaaagaga
     2521 agtttggaaa aggcagatgc cttggcctat ggcctagggc atggtggctt ggagttgatt
     2581 tttctaggcc ttattagttt actcaatctt tacatcgttc tttcggcagt tcaaactcag
     2641 aatccacagg ttatgcaatt actgtctgaa aatatgttaa aaaccattca gtcactttcg
     2701 gtctggcaga tttatttgct tggttttgag cgaatcttgg cgcttggttt ccaattactt
     2761 ttgacagttt gggtttacca agctgttcgc cagaagaaat ggatttatct cctagcagcc
     2821 tatggcttgc atgccttctt tgatctggca ccatctcttt tccaagtagg ctggttgaca
     2881 aatccagtct tggttgaagt gattctagca ctggagctcg ttctggtcgc ctatggaacc
     2941 aaggaaatct tttgtaaaaa atcataaaaa ggggggaacc tctttttctt atgcaaaatc
     3001 caaacaaggt atttttatgg tcgtcaaatg tctctaaaaa tggtataatg gaatgaattt
     3061 tgtaaaagga agagtgacat gtctgtaaga gaaaaaatgc ttgaaatctt agaaggaatt
     3121 gatatccgtt ttaaggaacc cttgcatagc tatagttata caaaagtagg tggagaggct
     3181 gattatttgg tctttccacg aaatcgtttt gagttggctc gcgttgtgaa atttgccaac
     3241 caagaaaata tcccttggat ggttcttggc aatgcaagca atatcatcgt tcgtgatggt
     3301 gggattcgtg gatttgtcat cttgtgtgac aagctcaata acgtttctgt tgatggctat
     3361 accattgaag cagaagctgg ggctaacttg attgaaacaa ctcgcattgc cctccgtcat
     3421 agtttaactg gctttgagtt tgcttgtggt attccaggaa gcgttggcgg tgctgtcttt
     3481 atgaatgcgg gtgcctatgg tggcgagatt gctcacatct tgcagtcttg taaggtcttg
     3541 accaaggatg gagaaatcga aaccctgtct gctaaagact tggcttttgg ttaccgccat
     3601 tcagctattc aggagtctgg tgcagttgtc ttgtcagtta aatttgccct agctccagga
     3661 acccatcagg ttatcaagca ggaaatggac cgcttgacgc acctacgtga actcaagcaa
     3721 cctttggaat acccatcttg tggctcggtc tttaagcgtc cagtcgggca ttttgcaggt
     3781 cagttaattt cagaagctgg cttgaaaggc tatcgtatcg gtggcgtaga agtgtcagaa
     3841 aagcatgcag gatttatgat caatgtcgca gatggaacgg ccaaagacta cgaggacttg
     3901 atccaatcgg ttatcgaaaa agtcaaggaa cactcaggta ttacgcttga aagagaagtc
     3961 cggatcttgg gtgaaagcct atcggtagcg aagatgtatg caggtggttt tactccctgc
     4021 aagaggtagt ggggacctga cagagccccg atcggttaat ctatgaaaaa gaaggaattt
     4081 atgccaattg aaaaaaccaa ttatcgaatt caaaaacgtc tctaaagttt ttgaagacag
     4141 caacaccaag gttctcaaag acatcaactt tgagttggaa gaagggaaat tctacaccct
     4201 tctaggtgca tctggttcgg ggaaatcaac tatcctaaac attattgcag gtttactgga
     4261 tgcgacgaca ggagatatca tgctagacgg tgttcgtatc aatgatattc caaccaacaa
     4321 gcgcgacgta cataccgtct tccaatccta tgccttgttc ccacatatga atgtgtttga
     4381 aaatgttgcc tttccacttc gcttgcgtaa aattgataag aaagaaattg agcagcgtgt
     4441 agcggaagtt ctcaagatgg ttcagttgga aggttatgaa aaacgttcca tccgcaaact
     4501 ttctggagga caacgtcagc gtgtggccat cgcccgtgct atcatcaacc aaccccgtgt
     4561 ggtcttgttg gacgagcctt tatcagcgct ggacttgaaa ttgagaacag acatgcagta
     4621 cgaattgcgt gaattacaac aacgattggg cattaccttt gtctttgtca ctcacgatca
     4681 ggaagaagct cttgccatga gtgactggat tttcgttatg aatgatggcg agattgtcca
     4741 gtctggaacc cctgtggaca tctacgatga gccaatcaac cactttgttg ccacctttat
     4801 cggggagtca aacatcttgc caggtaccat gattgaggac tacttggtcg aatttaacgg
     4861 caaacgcttt gaagcggttg atggtgggat gaagccaaat gaacctgttg aggtcgttat
     4921 tcgtccagag gacttgcgca ttacccttcc tgaagaaggc aagctccaag ttaaggtcga
     4981 tacccagctc ttccgtgggg tgcattatga aattatcgcc tatgacgaac ttggaaatga
     5041 atggatgatc cactcaaccc gtaaggccat cgtgggtgag gaaatcggtc tggactttga
     5101 accagaagac atccacatca tgcgtctcaa tgaaaccgaa gaagagttcg atgctcgtat
     5161 cgaagaatac gtggaaatcg aagagcaaga agcaggtctg atcaatgcga tcgaggagga
     5221 aagagatgaa gaaaacaagc tctaaactct ttgtagtgcc ctacatgctt tggattgccc
     5281 tctttgtatt ggcacccttg gtcttgattt tcggacaatc ctttttcaac attgaaggcc
     5341 agtttagttt agaaaattat aaatcttact ttgcgtcaca aaacttgacc tacctcaaaa
     5401 tgagtttcaa ctcagtgctt tatgcaggga ttgtgacctt tgtaaccttg cttatcagct
     5461 atccaacagc cctctttttg acccgtctca agcaccgtca actctggctc atgctgatta
     5521 tccttcctac ctggatcaat ttgctcctta aagcctatgc ttttatcggg atttttggtc
     5581 aaaatggctc tattaaccaa ttcttggaat ttatcggaat tggttcacaa cagttgcttt
     5641 ttaccgattt ttcctttatc tttgtcgcaa gctacatcga gctccccttt atgattttgc
     5701 cgattttcaa tgtcttagac gatatggata ataatctcat caatgctagt tacgaccttg
     5761 gtgcaactaa gtgggagacc ttccgtcatg tcatcttccc tctatctatg aacggtgtgc
     5821 gaagtggggt tcagtcggtc tttatcccaa gtttgagtct cttcatgctg acccgtttga
     5881 ttggtgggaa ccgcgttatc accttgggga cggctattga gcagaatttt ctaaccaatg
     5941 acaactatgg tatgggttca actatcggtg tgattctcat cctgaccatg ttcatcacca
     6001 tgtgggtgac taaggaaagg agagaacgat gaaaaaattt gccaaccttt atctgggact
     6061 ggtctttctg gtcctctacc tgcctatctt ttacttgatt ggctatgcct ttaatgctgg
     6121 tgatgatatg aatagcttta caggttttag ctggactcac tttgaaacca tgtttggaga
     6181 tgggagactc atgctgattt tggctcagac atttttcttg gccttcctat cagccttgat
     6241 agcgaccatt atcgggactt ttggtgccat ttacatctac cagtctcgta agaaatacca
     6301 agaagccttt ctatcactca ataatatcct catggttgcg cctgacgtta tgattggtgc
     6361 tagcttcttg attctcttta cccaactcaa gttttcactt ggctttttga ccgttctatc
     6421 tagtcatgtg gccttctcca ttcctatcgt ggtcttgatg gtcttgcctc gactcaagga
     6481 aatgaatggc gacatgattc atgcggccta tgacttggga gctagtcaat ttcagatgtt
     6541 taaggaaatc atgcttcctt acctgactcc gtctatcatt gctggttatt tcatggcctt
     6601 cacctattcg ttagatgact ttgccgtgac cttctttgta acaggaaatg gcttttcaac
     6661 cctatcagtc gagatttact ctcgtgctcg caaggggatt tcgctagaaa tcaatgccct
     6721 ttctgctcta gtctttctct ttagtattat cctagttgta ggttattact ttatctctcg
     6781 tgagaaggag gagcaagcat gaaaaaaatc tattcatttt tagcaggaat tgcagcgatt
     6841 atccttgtct tgtggggaat tgcgactcat ttagatagta aaatcaatag tcgagatagt
     6901 caaaaattgg ttatctataa ctggggagac tatatcgatc ctgaactctt gactcagttt
     6961 acagaagaaa caggaattca agttcagtac gaggcttttg actccaacga agccatgtac
     7021 actaagataa agcagggtgg aacgacctac gatattgcca ttccaagtga atacatgatt
     7081 aacaagatga aggacgaaga cctcttggtt ccgcttgatt attcaaaaat tgaaggaatc
     7141 gaaaatatcg gaccagagtt tctcaaccag tcctttgacc caggtaataa attctccatc
     7201 ccttacttct ggggaacctt aggaattgtc tacaacgaaa ccatggtaga tgaagcgcct
     7261 gagcattggg atgacctttg gaagctggag tataagaatt ctatcatgct ttttgatggg
     7321 gcgcgtgagg tgctgggact aggactcaat tccctcggct acagcctcaa ctccaaggat
     7381 ccgcagcagt tggaagagac agtggataag ctctacaaac tgactccaaa tatcaaggct
     7441 atcgttgcgg acgagatgaa gggctacatg attcagaata atgttgcaat cggcgtgacc
     7501 ttctctggtg aagccagcca aatgttagaa aaaaatgaaa atctacgtta tgtggtaccg
     7561 acagaggcca gcaatctttg gtttgacaat atggtcattc ccaaaacagt taaaaatcaa
     7621 gactcagcct atgcctttat caactttatg ttgaaacctg aaaatgctct ccaaaatgcg
     7681 gagtatgtcg gctattcaac accaaaccta ccagcgaagg aattgctccc agaggaaaca
     7741 aaggaagata aggccttcta tcccgatgtt gaaaccatga aacacctaga agtttatgag
     7801 aaatttgacc ataaatggac agggaaatat agcgacctct tcctacagtt taaaatgtat
     7861 cggaagtagg agataaacgt aagaagacga atcagtcaag ctggttcgtt tttaaggaat
     7921 agaagtcagt ttttagagcc ctatcttttt ctattctagt tgtttatttg tttatttgct
     7981 tatttgcttg cctagtagta tactaagcct atactcttca aaccacgtca gcgttgcctt
     8041 gccgtactca agtacagctt gaagctagct tcctagtttg ctttttgatt tttattgagt
     8101 attaacctta cagaaagcgg caacaaataa tgaaaatgtc tacttttttc aaaaaaagtt
     8161 tctggccaac ctttatgatt gttaaccaaa ctgctatact attccattta aatgatggct
     8221 tggatcgaca atacctaaca actgagtcca tatattgggt gataggcacc tttatatttg
     8281 gaaatattct agtagctgtg tttagtaata tgaaaatttg ggataaaaag aaaaatggca
     8341 gtaagaaaaa atatatcctg aaaaagtaat cagagatgta gggaattggt ctaattcaac
     8401 ggagatcatt tccagttgac gcaagcttaa aaaaacgtta taataagaaa gttgagaatt
     8461 gattttcact tgtcttagtc cagagaaatg gcggtgctgc gagccatcta agctaggaag
     8521 tcatgctact caatcataca attgcataag aacaagagaa tgacaagttc attgaatgaa
     8581 ggtggtaccg cggtttttcg cccttcgtga tatgagcttg tcttttgatt tttggaggtg
     8641 ttgatgaaaa catttcttgt caaacaaaag tttcgtcttg gaggcgaacg cttcgctatc
     8701 aaggatgaca ggggagaaat tgcctatcag gtggagggat cattttttaa gattcccaaa
     8761 acttttacca tctatgatgc ggctggtgaa caagtcagtc agatcagtaa agaaatcttg
     8821 accttgcttc ctcgttttga gattcagctt cgggatggct cgagttttgt cattcgtaag
     8881 aagttgacct tctggcgaga taagtatgag tttgataatc taggtcttcg tatcgagggc
     8941 aatatctggg atttgaattt caaattgctg gatgatcgcg atcagttgat tgcggaaatt
     9001 aagaaggaac tcttccatct gacctctacc tataccgtaa cggttcttga agacgcttat
     9061 gcagacctag tcatttccct ctgtgtcgcg attgactatg tggaaatgct ggaaagccaa
     9121 tcacattaaa caagtgaata aggagacaat atgaaacaac tatctagtgc acaagtacgc
     9181 caaatgtggc ttgatttctg ggcgaccaaa ggtcactcag tagaaccatc agtaagtttg
     9241 gttcctgtaa atgacccaac tcttttgtgg atcaactctg gggtagcaac ccttaagaaa
     9301 tactttgacg ggaccattat ccctgaaaat ccacgtatta ccaatgccca aaaggctatc
     9361 cgtaccaacg acatcgaaaa cgtagggaag actgcgcgtc accataccat gtttgaaatg
     9421 ctggggaact tctctatcgg ggattacttc cgtgacgaag ctatcacttg ggcttatgag
     9481 cttttgacaa gccctgaatg gtttgatttc cctgctgaaa aactttacat gacctactat
     9541 ccagacgata aagattctta caaccgctgg attgaagtgg gagtggatcc aagtcacttg
     9601 attccaattg aggacaactt ctgggaaatc ggtgcgggac cttctggacc agatacagaa
     9661 atcttctttg accgtgggga agcctttgac ccagaaaata tcggtcttcg cctgcttgca
     9721 gaagatattg aaaacgaccg ttatattgaa atctggaaca tcgttttgtc acaatttaac
     9781 gcagaccctg ctgttcctcg tagcgaatac aaggaattgc cacataagaa cattgatacg
     9841 ggcgctggtt tggagcgttt ggtggccgtt atccaagggg ctaagaccaa ctttgaaacg
     9901 gacctcttca tgccgattat ccgtgaagtc gagaaattgt ctggtaaggt ttatgaccaa
     9961 gatggcgaca acatgagctt caaggttatc gcagaccaca ttcgttctct ttcatttgct
    10021 atcggtgatg gtgcccttcc aggaaatgaa ggtcgtggtt atgttcttcg tcgtcttctc
    10081 cgtcgtgctt ctatgcatgg tcaaaaattg ggtatcaacg agcctttcct ttacaaattg
    10141 gttccaactg ttggaaaaat catggaaagc tactacccag aagtgcttga gaaacgtgac
    10201 tttattgaga aaatcgttaa gagcgaagaa gaatcatttg cccgtaccct tcactcaggt
    10261 caacactttg cccaaggcat tgtggcagac ttgaaagaaa aaggtcaatc tgtcattgct
    10321 ggtcaagatg tctttaaact ctatgatact tatgggttcc cagttgaatt gactgaagaa
    10381 atcgctgaag aagctggtat gactgtagac cgtgaaggtt ttgaagcagc catgaaagaa
    10441 cagcaagaac gcgcgcgtgc gtcagctgtc aagggtggct caatgggtat gcaaaatgaa
    10501 actcttcaaa acatcactgt agaaagtgtc ttcaactaca atactagcca attgtcttct
    10561 aaattggtag ctatcgttgc tgacaatgca gaagtaggag ctgtttcaga aggaactgcc
    10621 tctcttatct ttgcggaaac gtcattttat gctgaaatgg gtggacaggt agctgactac
    10681 ggacaaatct tggatgagtc aggtaagatt gtggctactg tgaccaatgt tcagaaagcc
    10741 ccaaatggtc aagcccttca tacagttgaa gtccttgcac cgcttgcctt gaaccaagaa
    10801 tataccttgg caattgatag caatcgccgt caccgtgtca tgaaaaacca cactgcgact
    10861 catttgcttc acgctgccct tcacaatatc cttggaaacc acgcaacaca ggcaggatct
    10921 cttaacgaag ttgaattcct tcgctttgac tttacccact tccaagcagt aactgctgag
    10981 gaacttcgtg cgattgaaca gcaagttaac gagaaaattt gggaagcact tgaagtgaag
    11041 acagttgaaa cggatattga cactgctaaa gaaatgggag ctatggccct ctttggtgag
    11101 aaatacggca aggaagttcg tgtcgtgact atcggtgact actctattga actttgtggt
    11161 ggtactcatg ttgacaacac ttctgagatt ggtctcttca aaattgtcaa agaagaagga
    11221 atcggttcag gaactcgccg tatcttggca gtgactggta aggaagcctt tgaagcctat
    11281 cgtgaacaag aggatgctct taaagctatc gcagcaacct tgaaagcacc tcaagtcaag
    11341 gaagtacctc acaaggtaga aggacttcaa gaacaacttc gtcaacttca aaaagaaaat
    11401 gctgagttga aagaaaaagc cgcagctgca gccgcaggcg atatcttcaa agatgttaag
    11461 gaagtcaacg gtcatcgtta cattgctagt caagtgtctg tatccgatgc cggtgccctt
    11521 cgtacttttg cagataactg gaaacaaaaa gactactctg atcttcttgt cctagttgcc
    11581 gctatcggtg acaaagtcaa tgtccttgta gcaagcaaga caaaagacct tcatgcagga
    11641 aaccttgtca aagaattagc accaatcatc gatggacgtg gtggtggtaa accagacatg
    11701 gccatggcag gaggaagcaa ccaagctaag atccaagaat tgttggatgc agtagcaggt
    11761 aaattgtaat caagtaaaga tctatccatt tgggtaggtc tttttgtgaa tacaaaaaag
    11821 ccaaatccgc ttggacctag cttggttatt atgagctatt agatggtatt gactgcccag
    11881 acacttacgg atctagctga gacagggaat tgtccataac cttcctcatc aattgtaact
    11941 tgaccttggt ggttaccaag taaatctaca aaggtttgat tagtccattc ttgaccgaca
    12001 aacattgact tgctgttttc ttggtcattt gagataagga ctgcgattgg ggattgattt
    12061 tcagcacctg aacgtaccca accgatacag ttagcatggt caaagtagtc attttgttct
    12121 ccataggcca agtcttttcg gatggctagg aggcggtcaa ggatttcttt gaaatcttct
    12181 tgagcatact ggcctgaaat cccatagtag tctccgtaaa agacacatgg aaggccgtct
    12241 tggcgtaaca aaatgagggc ataggctgct ggcttgaacc attcttcaac ggtagactca
    12301 agggcttgtc ctcgttgggt atcgtggttg tcgacaaaag tcacagcctt gtcaggcttg
    12361 agttcaacca ggctatctgt gaaaatgcca cgaaggtcat agtttgcgcc agcttgactg
    12421 gcttcaaaga gattctggtg gagacgaaca tcgacaaggt caaagtgttc ttccgttttt
    12481 tcgagatagt ccagattggc ttccttgtct gggttccaaa attcaccaaa aacatagaaa
    12541 tcgtcaccgt atttttcctt catatcgcgg atgaagttgc gcataaagaa agagtcaata
    12601 tgcttaacgg catccaaacg gaaaccagct acaccagtcg tttccatgaa ccaatcagcc
    12661 cagtcataga tgttttggat gacttcagga tgtttaaagt ctaggtcggc atacatgagg
    12721 tagtcgtagt ttccgttttc gttatcgacc aattccttgt tagcccagcc cttgttgtcc
    12781 ccttggatca gataaatccc agatttactg cgtttggcat cgtagtctgt accggtgaag
    12841 tggtaccaat gccagtggaa gccattatag gtatcttggc gaccatcgaa ggtaaaacta
    12901 gtccagccat tgatggtgaa gggttctcca agttcaactg tacggtctac aggatcaact
    12961 tcgataacct gaaaggcttc cctgttatcg gcagcagcct tgtggttgag aactacatcg
    13021 gccataggtt gaattccctg ttctttaagg gcttgaatgg cttgaagata gtcttctttg
    13081 aaaccatact tggtgcggac agtccctttt tggttgaact ctcctaagtc aaataagtca
    13141 tagaccccat agccgacatc tttttcgttg gttgccttga aggctggtgg catccagacg
    13201 tgactgatcc ccagatgagc taggtgtgga gcattttcag ccagacgcgt ccagtgttga
    13261 ccgtcgtggg gcagatacca ttcaaagtat tgcatgagtg tttgattttg catgatgttt
    13321 cctcttactt gtcaatcttg ttctttattc tatcataaag tatctctcgg cgcaaacgtt
    13381 tgcgtaagat agaaggaaac tattttaact acttaaaata aagtattgat ttttttgtat
    13441 caaagtgcta gtatagcgat gtataataca gataaagata ggagttgtcc catgattgaa
    13501 tttcaaaatg ttagtaagtt gtatggtgat aaagaggcct tgagtaatct caatttgcag
    13561 attgaaaatg gagagattat gggcttgatt ggtcataatg gggctggaaa atcgaccacc
    13621 ataaaatccc tagtcagtat catttcaccc agcagtggtc gtattttggt agacggtcag
    13681 gagttatcgg aaaatcgctt ggcgatcaaa cgaaagattg gctacgtagc agactcgcct
    13741 gacttatttt tacgcttaac ggccaatgaa ttttgggaat tgatcgcttc atcctatgat
    13801 ctgactagct ctgacttgga gactagtcta gctaggctat tgaacgtttt tgattttgct
    13861 gaaaaccgct atcaggttat tgaaactctt tctcacggaa tgcgtcagaa agtctttgtc
    13921 attggggcac tcttgtctgc tcctgatatt tgggttttgg acgaaccctt gactggtttg
    13981 gatccccagg ccgcctttga tttgaagcaa atgatgaagg aacatgcaca aaaaggcaag
    14041 acggtcttgt tttcaactca tgtccttgag gtagccgagc aagtctgtga tcggattgct
    14101 attttgaaaa aggggcattt gatctattgt ggtagtgtag agaacttgag gaaagaccac
    14161 ccagaccagt ttttggaaag tatctacctt agtcttgctg gtagaaaaga ggaggttgcg
    14221 gatgcgtctc aaggtcatta aaaaattagt tgatatcaat atcctctatt catctcaaga
    14281 agctaatctg gctaatctac gaaagaagca ggctaagaat cctgggaaaa aagtaaatgt
    14341 ttctgctaga gtcctaagtt cttacatttt ttccagtctc ttgatgctca tctgttttag
    14401 taatatagcc attcattttc cttttgagga aatgcctatt tattttagct cgatggttgc
    14461 tattttactg gtgctggcct tttcaacttc tttcactgcc ttttacaatg tcttttatga
    14521 gagtaaggac ctggcctcct ataggcccta tgcctttaaa gaatcagaga ttataatggc
    14581 caaaggtctg tctgtcctct tgccagctct aactggaatt gtaccaatcc tagcttattt
    14641 tctagccctc tatattagtc tagctccttc tctttggctg ggtttgcctt tgatgctact
    14701 gtccttgacc ttattatttg tctctgttac tttagtgacg gtagtggcag tacatttctt
    14761 ggctcagact agggtcttca gaaagtatca gtctattttt tcgaatgtga tgattgggat
    14821 aggagttctc atacctttaa tatttatctt ctttcttcag tcgacttttg gaagtattgt
    14881 tgacaaagtt agagacattc catttctcct ttatcctctt catatctttt acaaaatagc
    14941 agtggagcct ttttcgacag aagccttagt gggtctgctc gcttggatag gactaactct
    15001 cttcctgctt tatctgacca aaaagaaggt ccttcctcgt ttttatgacg tgatcctgct
    15061 taacagtgag gagaaggtca aaaaagaacg tcgcagcaag gagaggattt caactactaa
    15121 aaagggcttt ttccgtatgg ttttacgcta ccacctcacc ctcttgggac aggggactgg
    15181 tgtgattaca gtgcttttta caagtgcttt ccttccttat ctcatgatga tcagtctgat
    15241 ttccaaaatc cgagattctc agatagttcc agacattcat cctccatact ggttaccctt
    15301 gttttttgta ggagtgttta tagcagttgt caataacaat atcaccagcc tgcattcaat
    15361 tgccttgtcc ttggagaggg aaaatgttga ttttctgaag agtttaccct ttgactttgc
    15421 tcgttatgtg aaagtgaaat tttggattat ctttgctgtt cagtcctttt taccagttct
    15481 gactttgctc ggtctttctc tatatctagg cttgcccatc ctttcgatga tttaccttct
    15541 tgtagtctgg atcattgcca gtgtcatcct ttcttgccac cattacttta aggacgttaa
    15601 aaatctgtca accaattgga gtagcattac ggacctggtg aatcgttcaa atggcatagt
    15661 cgccatagtt ttattgttta tttatagtgc aatcctgatg gcccttgtaa ttgggagcat
    15721 attcttggtt cagtctctct cccctatcct tgccatcaac ttgggagtag gagctcttat
    15781 cgtcttgctt gctcttgcta tttttggcta tcattattac ctgtcacgca tattggcaga
    15841 aatagaaaaa agatgagata gttggttgct tgcttgataa attcaattcg acaaacgctt
    15901 ttatagtttg ttagaatgta gttgtaaatg attaagattg gtaatcaaaa atatagggag
    15961 gaatgttttg aataagaaat ataatatagt tctattattg ttgtttatag tttatttatt
    16021 gggatatttt tcaatttcaa aaacgttaat tcctataatg tgtgtgatcc aagtattttt
    16081 gatagaacat atatttagag ttcgaaatag aatgatgcaa ataggtgaaa ttttaattat
    16141 tgttgcttct ataatattat ttattgatag tatattgagt ttgtaacaaa aggcttttct
    16201 ataaaatcaa attttccaga tacctattga agcagattta tttcttcatc tttcttctac
    16261 tacctttgtc actaaatttg acagacacat attgctgatt caacctctct acctataatc
    16321 tcacagttaa cctgaggcta gtttcatagt ttgctatttg attttcgttg ataaaaagaa
    16381 atgctcctcc aagatggaag agcatttttt attgtgattc ttacacattt acttcctagt
    16441 tttgcaggaa gtctagtata ccatttttta aaagaagagt aaaaaagcaa gggtagtttc
    16501 ttttttgaga attgtctaaa agtttgatat aatggtagtt atgaatagaa taagagtcag
    16561 caaaagggtt gaaaagaagc ttgctaaggg gctagtttta ctagaagcca gtgatcttga
    16621 gaatgtcaat cttaaggatc aggaagtaga ggtgcagggt caggaaggaa actttcttgg
    16681 gactgcctac ctttctcagc aaaacaaggg cttgggctgg tttgtcagca aagacaaggt
    16741 ggccttcaat caagctttct ttgaaacgtt gtttagaaaa gccaaagaaa agagaaacgc
    16801 ctactatcaa gatgatttga caactgcctt tcgtctcttt aatcaagagg gagatggctt
    16861 tgggggtctg acagtggacc tttatggcga ctacgccgtc ttttcttggt ataactctta
    16921 tgtttatcag attcgtcaga ctatatcaga agcctttaga caggttttcc ctgaggtttt
    16981 aggagcttat gagaaaatcc gctttaaggg tttggactat gaatctgccc atgtttatgg
    17041 tcaagaagca cctgactttt tcactgtttt agaaaatggt gtcctgtatc aagtctttat
    17101 gaatgatggc ttgatgacag gaattttcct agaccagcat gaggttcgcg gtagtttagt
    17161 tgacggcttg gctatgggta aatccttact caatatgttt tcctacacag cggctttttc
    17221 agtagctgcg gccatgggag gagctagcca gacaacttct gttgatctag ccaaacgttc
    17281 acgagaattg tctcaagcgc attttcaggc aaatgggctc agcacagacg agcatcgttt
    17341 tatagtcatg gatgtctttg agtatttcaa atatgccaaa cgcaaagact tgacctacga
    17401 tgtgattgtc ctagatccgc ctagctttgc tcggaataaa aaacaaactt tctctgtggc
    17461 caaggattat cacaagttga tttcccagag tcttgagatt ttaaatccgg gagggattat
    17521 cattgccagt accaatgctg ccaatgtttc ccgtcagaaa tttacagaac aaattgataa
    17581 aggttttgca ggaagaagtt accagatttt aaacaaatat ggtcttccag cagattttgc
    17641 ctataataaa aaagatgaaa gtagtaatta cctcaaggtg attagtatga aggttagtaa
    17701 atgaaattaa tcgtttcagt aatgccaaga agtttagagg aggctcaggc tctggatgcc
    17761 acgaggtact tggatgccga catcattgaa tggcgtgccg actatctgcc taaagaagcg
    17821 attttgcagg tagctccagc catttttgaa aaattcgcag gccgtgagtt ggttttcacg
    17881 ctacgaactc gctccgaagg tggagaaatc gacctttctc cagaagagta tatccatcta
    17941 atcaaggaag ttgcgcaact ctatcaacca gactatattg attttgagta ctatagctac
    18001 aaggatgttt ttgaggaaat gctggacttc ccaaatcttg ttttgagtta ccataatttc
    18061 caagaaacac ctgagaacat gatggaaatc ttgtcagagt tgacgatcct aaatccaaaa
    18121 cttgttaagg ttgcggtgat ggctcacacg gagcaggatg tcttagactt gatgaactat
    18181 acacgaggct ttaaaaccct caatcctgaa caggaatatg tgaccatttc tatgggtaag
    18241 gtgggcaagg tctctcgtat cactgcggat gtgactggtt cgagttggtc ttttgccagt
    18301 ctggatgagg ttagtgcccc tgggcagatt tctctagcta gcatgaaaaa aatcagggag
    18361 attttggatg aagcttgatg gctatacacg tttagctgca gttgttgcca atcctattaa
    18421 gcattctatt tctcccttca tccacaatag agcctttgag gcgacagcta ccaacggtgc
    18481 ttatgtggct tgggagattg aagcgagtga cttggcagaa acagtggcca atattcgtcg
    18541 ctaccagatg tttggcatca atctgtccat gccctataag gagcaggtga ttccttattt
    18601 ggatgagcta agcgatgaag cgcgcttgat tggtgcggtt aatacggttg tcaatgagaa
    18661 tggcaattta attggatata atacagatgg caagggattt tttaagtgct tgccttcttt
    18721 tacaatttca ggtaaaaaga tgaccctgct gggtgcaggt ggtgcggcta aatcaatctt
    18781 ggcacaggct attttggatg gcgtcagtca gatttcggtc tttgttcgtt ccgtttctat
    18841 ggaaaaaaca agaccttacc tagacaagtt acaggagcag acaggcttta aagtggattt
    18901 gtgtgcttta gaatatgttt ctgaactgca agcaaggatt gccgagtcgg atttgctagt
    18961 taatgccacc agtgtgggca tggatggcca atcctctcct gttcctgaaa acatagtctt
    19021 accagaaact cttttagttg cagatatcat ataccaaccc tttgaaacac cgtttttgaa
    19081 atgggctaga agtcagggca atccagcagt caatggtctg ggaatgttgc tctatcaagc
    19141 tgcagaagct tttcaactgt ggacaggcaa ggaaatgccg acagaagaga tttggcagtc
    19201 tttaacagaa aaataccaat aaagaaaggg agactctcct atgaaaatca gaatcgatat
    19261 tcctcatcat ccttatgata ttcagattga aaaaggttgt atggcccagg ctggtcagtg
    19321 gttgcgagaa ctctggcaac cgcaaaaggt agtcattgtg acagataacc atgtagcctc
    19381 tctctatgca gagaaggtca agctcagcct agaagatgct ggttttcagg tagctgtttt
    19441 tgatttctta gaaggtgaag aaagaaagaa tttaactact gttcagaaag tctatgaatt
    19501 tctagtcaag caaggtctga ctcgtagcga tggaatcgtt gctcttggtg gtggcgttgt
    19561 tggggacctg gctggctttg tagcctctac ctatatgcgg ggtattcact ttgttcagat
    19621 tccgactagt ttgacagctc aggttgattc ttctatcggt ggaaagacag gcgttaacac
    19681 accatttgct aaaaatatgg tggggacctt tgcccaacca gatggggttc tgattgatcc
    19741 acttgttctt gaaaccctcg gaaaaagaga gttgattgaa gggatgggtg aagttatcaa
    19801 gtatggcttg attgaggatc cagaactgtg ggctctcttg acgggactga atggttctgt
    19861 tgagagtatt ttggaacatg cagagacctt gattgaacat tcttgtcagg tgaagcgcaa
    19921 gatggtggtt gaagatgagt tggacaatgg tattcgtctt tacctcaatt ttggccacac
    19981 tattggccat gccatcgaag cgactgccgg ttatggcaag gtcatgcatg gagaggctgt
    20041 tgccatggga atggtacaga tttccaagat tgctgaggaa aaaggcctca tgccagctgg
    20101 cattacccaa tctatcacag agatgtgtca gaaattcggc ttgcctgttg actatgaaaa
    20161 ttgggaagtt gacaagcttt atcaggctct tactcatgac aagaaagcgc gtggcaacac
    20221 cttgaaattg gtcttggtgc cagagcttgg ttcagcgatc attcacccag tttctctgga
    20281 agagatgaaa gactacttgg taaaataagg agagtgtatg agatatttaa ctgcaggaga
    20341 atcacacggc ccccgtctaa cagctattat tgatggaatt ccagctggac ttccattgac
    20401 agctgaggat atcaatgagg accttagacg ccgtcagggt ggctacggtc gtggtggtcg
    20461 tatgaagatt gagaatgacc aggttgtctt tacttcgggc gttcgccacg ggaagacgac
    20521 aggggcgcct attactatgg atgtcatcaa taaggaccac cagaaatggc tggacatcat
    20581 gtctgcggag gacattgaag accgtcttaa aagcaagcgg aaaattactc atcctcgccc
    20641 aggtcatgcc gatttggttg gggggattaa gtaccgtttt gatgatttgc gaaattcttt
    20701 ggagcgttca tcagctcgtg aaaccaccat gcgggtggca gttggtgcag tagccaaacg
    20761 cctcttggct gagttggata tggagattgc caaccatgtc gtggtctttg gtggcaagga
    20821 aatcgatgtt cctgaaaatc tgacagtcgc tgaaattaag caaagagctg cccagtctga
    20881 agtttctatt gtcaaccaag aacgagaaca ggaaatcaag gactatattg accaaatcaa
    20941 acgtgatggt gataccatcg gtggggttgt ggagacagtc gtcggaggcg ttccagttgg
    21001 tcttggttcc tatgtccaat gggatagaaa attggatgca agattggctc aagctgttgt
    21061 ctctatcaat gcctttaaag gggtggaatt tggtcttggc tttgaggctg gttatcgtaa
    21121 aggcagccaa gttatggatg aaattctctg gtctaaagaa gacggttata ctcgccgtac
    21181 caataatcta ggtggttttg aaggtggtat gactaatggg caacccatcg ttgttcgtgg
    21241 ggtcatgaaa cccattccta ctctttataa acctcttatg agtgtggata tcgaaaccca
    21301 cgaaccttac aaggcaaccg tggagagaag tgatccgact gctcttccag ctgcaggaat
    21361 ggtcatggaa gcagttgtag caacggttct ggcgcaagaa atcctcgaaa aattctcatc
    21421 agataatctt gaggaactaa aagaagcggt agccaaacac cgagactata caaagaacta
    21481 ttaaggagtt cctatggcaa aaacaatcta tatcgcaggt cttgggttga ttggagcctc
    21541 tatggcactt ggtatcaaac gcgatcatcc agattatgaa attttaggtt ataatcgtag
    21601 tcaagcttcg agagatatcg ccttgaaaga aggcatgatt gaccgtgcaa cggatgattt
    21661 tgctagtttt gctcctttgg cagatgtcat tatcctcagc ttgccaatca aacaaactat
    21721 tgctttcatt aaggagttgg ccaatttgga tttgcgagaa ggcgttatta tttcagatgc
    21781 tggttcgacc aagtcaacca ttgtggatgc ggcggagcag tatttggctg gcaagtctgt
    21841 tcgctttgtc ggggcccatc ccatggctgg tagtcacaag acaggggctg cttcggcaga
    21901 tgtcaatctt tttgaaaatg cctattatat ctttacacct tcaagcctga caagtcagga
    21961 cacgcttaag gaaatgaagg atctgctttc aggtcttcat gctcgtttta tcgagattga
    22021 tgccaaggag catgatcgtg tcacttctca gattagccat tttcctcata ttttggcttc
    22081 tagtctcatg gagcagactg cggtctatgc tcaagagcat gagatggcaa ggcgctttgc
    22141 ggcaggtggt tttcgagata tgacccgaat tgcggaaagc gagccaggaa tgtggacctc
    22201 cattctcttg tccaatagcg agatcattct ggatagaatt gaggatttca aggaacgttt
    22261 ggaagcgatt ggtcaggcca ttagtaaggg agatgaagag caaatttgga acttttttaa
    22321 ccaagcgcgt gaacaacgcc agaccatgga aatccataag cgtggtggtg tggatagctc
    22381 ttacgacctc tatgttgacg ttcctgatga agaagatgtc atcctgcgga ttttggaact
    22441 gctacgtgga acttccttgg ttaatatcca catcaacgag gaaaatcgtg aggatattca
    22501 cggaatccta caaatttcat ttaaaaatgc tcaagacttg gaaagagctg agcatctcat
    22561 aacagaaaat actgactata cagtcgtcat caaataagga gaagaacatg tcaaatattt
    22621 acgatagtgc aaacgaactc agtcgcggtc tacgcggatt accagaatac aaggctgtta
    22681 aagcagctaa agatgcgatt gcagcagatg ctgaggcaag caaaatcttt acagattatc
    22741 ttgcctttca agaggaaatt caaaaactag cacagacagg tcaaatgcca gatgcgtcct
    22801 tccaagctaa gatggaaggc tttggtaaac agattcaagg aaatagcctc ttgtcagaat
    22861 tctttaccaa gcaacaacaa ttggccattt acctttctga cattgaaaaa attgtttttg
    22921 aaccagtttc agaattgctg aaataagaaa agaactatcc taaagtcagg aatttttaag
    22981 gaatttctgg ctttttatga taaaataggt aaaagtattg caagtatgag gtccagtatg
    23041 aaactaaaaa caaacattcg ccatttacat ggtagtatcc gcgtcccagg tgacaagtct
    23101 atcagccacc gttccattat ctttggaagt ttggctgagg gtgagaccaa ggtttatgat
    23161 attctgcgag gcgaagacgt tctttcgacc atgcaggttt ttcgtgacct tggtgttgaa
    23221 attgaggata aagatggggt tattaccatt caaggtgtag gcatggctgg cttaaaagcg
    23281 ccgcaaaatg cccttaatat gggaaattct ggcacctcga ttcgcctgat ttcaggtgtc
    23341 cttgctggtg cagatttcga agtagagatg tttggagatg atagtctttc caaacgtcct
    23401 atggaccgtg tgacccttcc actgaaaaaa atgggcgtca gcatttcagg gcaaactgaa
    23461 cgagacttgc ctccccttcg cttaaaaggg acgaaaaacc taagccctat tcattatgag
    23521 ttgccaattg cctctgccca agtcaagtca gccttgatgt ttgcagcctt acaagctaag
    23581 ggggagtcag ttattatcga aaaagaatac acccgtaatc atactgaaga tatgttgcaa
    23641 caatttggtg gtcatttaag tgtggatggt aagaaaatca cagtccaagg gccacaaaaa
    23701 ttgacaggac agaaggtggt cgtaccagga gatatttcca gtgcagcctt ttggttagtc
    23761 gcaggtttga ttgctccaaa ttctcgtcta gtgctgcaga atgtggggat caacgaaact
    23821 cgcaccggta ttattgatgt cattcgtgcc atgggtggaa aattggaaat aactgaaatc
    23881 gatccagtcg ctaaatctgc aaccttgatt gttgagtctt ctgacttgaa aggaacagag
    23941 atttgtggcg ctttgattcc acgtttgatt gatgaattgc ctattattgc cctacttgcg
    24001 acccaagccc aaggtgtaac agttattaaa gatgctgagg agctcaaggt caaggaaaca
    24061 gaccgtattc aggttgtggc agacgcctta aatagtatgg gagcagatat tactcctacg
    24121 gcagatggga tgattatcaa aggaaaatca gctcttcacg gtgctagagt caatacgttt
    24181 ggtgaccacc gtatcggcat gatgacagct atcgcagccc tattggttgc agatggagag
    24241 gtggagcttg accgtgcaga agccatcaat accagctatc ctagtttctt tgatgatttg
    24301 gagagcttga ttcatggcta aggtgttatt agggtttatg ggggctggaa aatcaactat
    24361 tgcaagaggc ttggacccta attaccttga tatggatgct ctgattgaga agcgcctagg
    24421 tatgtccatt gcgaattttt tcgctgaaaa gggagaatca gcctttcgtc aggtagaatc
    24481 agaagtccta gctgatttac tacaaacaga ccaagtcgtg tcaactggag gaggagtggt
    24541 tatttctcag agaaatcgtg acttactcaa gactaataca gataacatct acctgaaagc
    24601 agattttgaa accctctacc tacgtatcgt agctgataag gacaatcagc gaccgctttt
    24661 tctaaataat agcaaggaag aactagtagc tatttttcaa gaaagacagg cttggtatga
    24721 ggaagtggct agtcgggttt tggatgtgac caagctaagc ccagaggaaa ttatagagga
    24781 actaagatga aaattgctta tctaggtccc aaaggatcat tttcacacca cgttgtgcag
    24841 acagcttttc ctcatgagga attgcaggct tttgccaaca ttacagatgt tatcaaggct
    24901 tatgagcaag gattagtgga ctattctgtg gtgccagttg aaaattctat tgagggtagt
    24961 gttcatgaaa ccttggacta tctttttcat caggctcaca tccaagcagt agcagaaatc
    25021 gttcagccta ttcatcagca gttgatggtg gttccaggcc atactaagat tgaaaagatt
    25081 ttttcacatc cacaggcctt ggctcaagga aagaaattca tcgatgaaca atatccagag
    25141 gctcaaatcg aggtaacagc tagtacagct tatgcggccc gttttatttc cgaacatcca
    25201 gaccagccct ttgcagcagt tgcacctaga agttctgctg aagaatatgg attggaactg
    25261 attgccgagg atattcagga aatggaagcc aatttcacac gtttctgggt tctaggagct
    25321 gaaaagccta gtattccctt gcaagcacaa actgaaaaga tgagtttggc cttgacatta
    25381 cctgacaacc ttccaggtgc actttataag gccctgtcga cctttgcttg gcgaggaatt
    25441 gacttgacaa aaattgaaag tcgtccactc aagacagcac tgggtgaata ctttttcatt
    25501 atcgatgtgg attataccga taaggacttg gtccactttg cccaaaaaga attagaagcg
    25561 attggaatcc agtataaaat tctgggtgcc tatcctattt atccaatatc agaccatgga
    25621 aaggagagaa gatgagtaaa gaaaatccct taagtcatca tgagcagttg cgttatgatt
    25681 atttgctaaa aaatattcac tacctcaatg agagagaaaa aaatgagttt gcctatttgc
    25741 aagaaaagct aactcttgct aggagaaata gtagctctag cttggaacaa gaaagagaag
    25801 agcaggttga cttaccaagt tatgcgaacc ggagtcgctc acaatccaaa tcacaagcac
    25861 tctcttcccc tccaaaaaag aaaagacgga agctccgtct taaacgaatt tttatggtga
    25921 ttttttcact tttggtctgt gtggctttgg ccatggtatt catgtttttg cgtggttacc
    25981 aagatgctag cgcaaagaaa actgctgatg cccgggcagc tcaagtagaa gtctttaatg
    26041 gtcaggacac tagagatgga gttaatattt taatcatggg tactgatggt cgaatcggcc
    26101 agaacagtgt tgagacacga actgactcta ttatggtatt aaatgtcggg ggctcagata
    26161 agaaaatgaa gctagtcagt ttcatgcgtg ataatttggt ctatatagat ggttatagtc
    26221 aagtgattaa cggtagaaaa cagacagata acaagttaaa cgtagcctac gagttaggag
    26281 aacaagaggg gcaaaaaggg gcagaaatgg ttcgccaagt cttgaaagat aattttgact
    26341 tggacattaa gtactacgcc ttggttgatt tccaggcctt tgccacagcg attgacacac
    26401 ttttccctga tggggtgacg attgatgctc aattttcaac attgaatggg cgtcccctaa
    26461 cagaagctac agtcggagat gatttatacg ctaccgagac tgagtctcca acccaaacca
    26521 ttaaagtcgg aaaacagcag atgaatggct cgaccctgct caattatgct cgtttccgtg
    26581 atgatgatga ggcggattac ggccgtacaa aaagacagca acaagtttta acagcaattt
    26641 tagagcaaat taaagatccc actaaacttt tcactggttc tgaagctctt ggaaaggttt
    26701 ttgctatgac ctcaaccaac gtaccctata ctttcctcct aacaaacggt ttatctgttt
    26761 tggatggagc aaaaaatggt attgaaaaat tgacgattcc agaactgggt gactgggtag
    26821 atgcctatga tgtttatgga ggcttgggct tgctggttga tcaaaacaaa tatcaaacca
    26881 agctcgctca aatgggcttg agataagata atactcaatg aaaatcaaag tgcaaactag
    26941 gaagctagcc gcaggctgct aaaaacacag ttttgaggtt atagataaga ctgacgaagt
    27001 cagttaccta tacctacggc aaggtgaagc tgacgtgctt tgaagagatt ttcgaagagt
    27061 ataagacaga aaaatcaaag tttgatagct atttggatag cagtcaggct ttgatttttt
    27121 acagtctgca atagattttc accccttgtt tgtggtataa tgaaacgata cgatagaaag
    27181 aataatgaac aatatgactg atttaaaagc aattcaggct cgtagtctgg agatggctga
    27241 atattttgtg gccttttgta aagaacatga tttgctctgt tatctctgtg gcggaggcgc
    27301 tattggtacc cttcgaaaca agggatttat tccttgggac gacgacctag acttttttat
    27361 gcctcgtaaa gattatgaga aattagcaga attatggcct cgttatgcag atgaacgtta
    27421 tttcttgtca aagagttaca aggattttgt tgatcgtaat ctttttatta ccattcgtga
    27481 caaggaaacc acctgtatca agccttatca gcaggatttg gatttgccac atggtctggc
    27541 cttggatgtt ttgcctttgg attattatcc gaaagatcca gctgagcgga aaaaacaggt
    27601 tcgttgggcc ttgatttatt cactcttttg tgcgcaaact attccagaaa agcatggtgc
    27661 tctcatgaaa tggggaagtc gcattttact gggtttgact ccaaaatctc tccgttatcg
    27721 catctggaaa aaagctgaga aagaaatgac taagtatgat ttggctgatt gtgatggcat
    27781 tacagaatta tgctcaggtc ctggctacat gagaaacaag tacccaatca catcttttga
    27841 agacaatctt ttcttgccat ttgagggaac agagatgcct attccaatcg gctatgatgt
    27901 ctatctcaga actgcttttg gggattatat gacgcctcca ccagcagaca agcaggtacc
    27961 gcatcatgat gctgtcatcg ctgatatgga taagtcttat acagaataca agggagaata
    28021 tggtggctaa gaaaaaaatc ttatttttta tgtggtcttt ttctcttgga ggtggtgcag
    28081 agaagattct atcaaccatt gtttcaaatc tggatccaga aaagtatgat attgatattc
    28141 ttgaaatgga gcactttgac aagggatatg aatctgttcc aaagcatgta cgcattttaa
    28201 aatcccttca agattatcgc caaaccagat ggttacgagc ttttttgtgg agaatgagaa
    28261 tttattttcc aagactggct cgtcgtttgc ttgtaaaaga tgattatgat gttgaagttt
    28321 cttttaccat tatgaatcca ccactgttgt tctctaaaag aagagaagtc aagaagatat
    28381 cttggattca tggaagtatt gaagaacttc ttaaggatag ctctaaaaga gaatcacata
    28441 gaagccagtt ggatgctgcg aatacaattg tagggatttc aaaaaagacc agcaattcta
    28501 tcaaggaagt ttatccagat tatgcttcta aattacagac aatctacaat ggatatgatt
    28561 ttcagactat tctagaaaaa tctcaagaga agatcgatat cgagattgct cctcaaagta
    28621 tctgtactat cggacggatt gaggaaaata agggttctga ccgtgtagtg gaagtgatac
    28681 gattattaca ccaagaggga aaaaactatc atctctattt tatcggggct ggtgatatgg
    28741 aagaggaact gaaaaaacga gtcaaagagt atgggattga ggactatgta catttccttg
    28801 gttatcaaaa aaatccttat cagtatttat ctcagacgaa agttctcttg tctatgtcta
    28861 aacaagaagg ttttcctgga gtgtatgtgg aggccttgag tctgggactc ccttttatct
    28921 ctacggacgt tggaggggct gaggaattat cccaagaagg acgatttgga caaatcattg
    28981 agagcaatca agaggcagct caggcgatta ctaattacat gacttctgcc tcaaactttg
    29041 atgtcgatga ggctagccaa ttcattcaac aatttacaat tacaaaacaa atcgaacaag
    29101 tagaaaaact attagaggag tagcatggaa actgcattaa ttagtgtgat tgtgccagtc
    29161 tataatgtgg cgcagtacct agaaaaatcg atagcttcca ttcagaagca gatctatcaa
    29221 aatctggaaa ttattcttgt tgatgatggt gcaacagatg aaagtggtcg cttgtgtgac
    29281 tcaatcgctg aacaagatga cagggtgtca gtgcttcata aaaagaacga aggattgtcg
    29341 caagcacgaa atgatgggat gaagcaggct cacggggatt atctgatttt tattgactca
    29401 gatgattata tccatccaga aatgattcag agcttatatg agcaattagt tcaagaagat
    29461 gcggatgttt caagctgtgg tgtcatgaat gtctatgcta atgatgaaag cccacagtca
    29521 gccaatcagg atgactattt tgtctgtgat tctcaaacat ttctaaagga atacctcata
    29581 ggtgaaaaaa tacctgggac gatttgcaat aagctaatca agagacagat tgcaactgcc
    29641 ctatcctttc ctaaggggtt gatttacgaa gatgcctatt accattttga tttaatcaag
    29701 ttggccaaga agtatgtggt taatactaaa ccctattatt actatttcca tagaggggat
    29761 agtattacga ccaaacccta tgcagagaag gatttagcct atattgatat ctaccaaaag
    29821 ttttataatg aagttgtgaa aaactatcct gacttgaaag aggtcgcttt tttcagattg
    29881 gcctatgccc acttctttat tctggataag atgttgctag atgatcagta taaacagttt
    29941 gaagcctatt ctcagattca tcgtttttta aaaggccatg cctttgctat ttctaggaat
    30001 ccaattttcc gtaaggggag aagaattagt gctttggccc tattcataaa tatttcctta
    30061 tatcgattct tattactgaa aaatattgaa aaatctaaaa aattacatta gaacgggggt
    30121 gaccaagtga ttgatgggaa acgattatta tttagtttga ccatagtcag ttatgccttg
    30181 acgctagtaa gtggaattgt gtatctgttt aataataata atgttagctt actttctact
    30241 ttattgttct tgttggttag tagcttaatt gcttgttgga atgatatcaa gtattactta
    30301 atccatttta ttttctattt aaccattttt gtatttctgg tatcaagacc gaccattgat
    30361 tattttaggg atggtgcttt ggatacctat catccaatag cctatcgttt tgcctttata
    30421 gttgtcatgg tttcgattct gggcttgacc acaggaggca ttctggctcg ttacttcata
    30481 gctaggaaga aaataaaagt agcaaatata ggaaattctc taaaagaggt ttatatcaag
    30541 cggttacgct ttgtatcact aggagttttt cttctaacct atcctttcta tttcattcgg
    30601 ttatttgaac ggctcttgta tcgtttgcag acttcctact atgcctacta tgcaaatttt
    30661 gaaagtaaac tgccttattt tacctacatt ttgtctacct ttacggtcta tgcaatgtgt
    30721 atgtatctgg caaccaagcc aaagaaattg caggccacag cagtgcttgt ctcctttatt
    30781 gcagctaata ctattcattt ggcaattggg acacgaaatc cctttatttt aagtatttta
    30841 tttgcttttg tttattactt tatgcgggag caaactgaaa aaggaaaatg gattgggttt
    30901 aaagaaaagt tagcgatttt tgtaggttct cctattctca tgttagcgat gggagtactc
    30961 aattatgtac gggataatgt ccaagtttcc catacaggtt tctgggatat cttacttgac
    31021 tttatctata aacaagggac tagttttggt gttctggctc gaggttttct atttaacagt
    31081 agcctccctt accgagattt ccgtaatttt acttttggtc ctgttcttga ttattttgca
    31141 agggggagtt tgggagccat tttcggagga aaagcctttg aacatacaac caatagtgtg
    31201 gaactagcta ttgatagtaa tagttatgcc cacaatctat cctatcttgt cttgaacaag
    31261 gaatacctga aagggcatgg tatcggaagt agttatatca tggagttgta taccgactat
    31321 ggtatgattg gagtctttct gcttagtttc ttactcggcg tattatttat agccatgctg
    31381 caagtagcct atcgctcaag gacaatccta tttgctttat ccctactcat cttgaataat
    31441 ctattcttta tgccaagaag cagcttttca gaaagtttct tcaatttatt tacaatgcaa
    31501 ttctggggaa ttgttcttgt gattatattt atagcaaaaa tgcttacaaa ggaaaactag
    31561 tatctactaa acaaaggaga aaaaaatcat gtttgaacat tattcagtag ctgatttgtt
    31621 tgcaaatctt tataaaaagc gaaaagcaaa tattttagct ctcatcgctt tatttgctct
    31681 cattgctgta ccatttacaa ttaaagcagt taggaataaa aacactgtca aagatacaac
    31741 aagttattca acttatctta tctataaaat cactcctcca aaagagtcgg ccaaaacgat
    31801 tttgaatcat caaattggtg gttatagtga tttttatggg aaattgattg atggtaattt
    31861 gaatggagct tatcttttca atgatgtaga acccagtgag ttgaaaaaaa ttgccagtga
    31921 attagacacg acagaaacaa ccttgaaaaa ttcaacgaat gactattggt ggaaaaaatt
    31981 gaccgtctac tatatgattg acgatgcagg ggttggtgtg aaaattttga catcaagtaa
    32041 agatgccaat gacttgttag agaaaaaaat tgatgggttg attgagaaat ttaaacatgc
    32101 ctatgcaaat gtgaaaattg aaaaactgga aaccatcaac tctaaagaat tgaacgcaaa
    32161 tggtgaaaca gcgcttggct taaatgtgaa aaatctgatt cttcgtttag ttgttattgg
    32221 agtggtttgt gtgattttgg ttgtgatggg aaatgtgtta gtttatctct ttaatccaac
    32281 aatcaataga gtaggtgatt tttctcagta tcaaattgat tttgtaacag agattacaac
    32341 aattgctaac ctagcagatg ttttgtcata caaaaatact ggacaggaat tgaccatcgt
    32401 tagctcaaat aaagctatcc tagataaatt gaaacagagt caagaagctt taaaaggaat
    32461 gcattttgta gatttacagg atgtatcatc tcttttggaa agagatacag tccttcttgt
    32521 tgaagagtac ggagtgactc gttataagaa atttgagcaa agtcttcaaa ttctcagaaa
    32581 cttaaatcgt tctatcctcg gtgtagcaac ctttaaatta taagtattct gatgtataag
    32641 gtcttcaaag tcggctaaga gccgattttg aaggcttttt ctatctgtct gcagaaattt
    32701 tcttttgata aaatcgtaaa aatctagtat aatagataga actgaaagta tgaggttact
    32761 agcaatgaaa atgaaacaaa ttagtgatac aactttaaaa atcacgatat ctttagagga
    32821 tttgatggat cgtggaatgg agattgctga ctttctcgtt cctcaagaaa aaacagaaga
    32881 gttcttttat gctatcttgg atgagctaga gatgcctgat agctttctgg atacaggcat
    32941 gttgagcttc cgtgtgactc caaaacctga taaggtagat gtctttgtga ccaagtcaaa
    33001 gattgaccaa aatctagatt ttgaagactt atcggatttg ccagatatgg aagaattggc
    33061 tcaaatgtct ccagatgaat ttatcaaaac cctggaaaaa agcatcgcag acaaaaccaa
    33121 ggatgatatc gaagccattc aatctcttga gcaagttgaa gccaaggaag aagaacaaga
    33181 gcaggctgaa caagaagctg agagtaagaa agaaccttac atctactaca tcctttcttt
    33241 tgctaagttg gctgacttgg tagcttttgc caagacagtg acttttgaaa tggaaacttc
    33301 tgaactctac aaaatgaacg agcgctatta tttgaccatt ttagtggata ttgaaaatca
    33361 tccaagccca tatccagctt ggctgttggc ccgtatgcgc gagtttgcag aggatagtga
    33421 tatcagtcgc tcagtcttac aagagtatgg tcaagttttg atgagtcacg atgcagtgct
    33481 caatctgcaa aaaatcggct aatcttttct ggaaagctat tttcagattt taagaagagc
    33541 gaatcgtctg attcgttttt tctttttata ctgaaatagt gatttactat aataggaatt
    33601 ttcacaaaat tctgttataa tggctatatt agaaaatttc gaggagataa agatgacagt
    33661 taaaattgct ttactaggat ttggtaccgt tgcaagtggt gtgcctttcc tcctaaagga
    33721 aaatggagga aaaatcaatc aatcagcaca ttcagatatc aaagttgcta aggtattggt
    33781 caaggatgaa gatgaaaaaa atcgcttgct tgcagcaggg aatgacttta actttgtaac
    33841 caatgtggat gatattttat cagaccagga tattactatc gtagtggaat tgatggggcg
    33901 tattgagcct gctaaaacct ttatcactcg tgccttggaa gctggaaaac acgttgttac
    33961 tgctaacaag gaccttttag ctgtccatgg cgcagaattg ctagaaatcg ctcaagctaa
    34021 caaggtagca ctttactacg aagcagcagt tgctggtggg attccaattc ttcgtacttt
    34081 agcaaattcc ttggcttctg ataaaattac gcgcgtgctt ggagtagtca acggaacttc
    34141 caacttcatg gtgaccaaga tggtggaaga aggctggtct tacgatgatg ctcttgcgga
    34201 agcacaacgt ctaggatttg cagaaagcga tccgacgaat gacgtagatg ggattgatgc
    34261 agcctacaag atggttattt tgagccaatt tgcctttggc atgaagattg cctttgatga
    34321 tgtagtccac aagggaatcc gcaatatcac accagaagac gtagctgtag ctcaagagct
    34381 tggttacgta gtgaaattgg ttggttctat tgaggaaact tcttcaggta ttgctgcaga
    34441 agtgactcca accttcctac ctaaagcgca cccacttgct agtgtgaatg gcgtaatgaa
    34501 cgctgtcttt gtagaatcta tcggtattgg tgagtctatg tactacggac caggtgcggg
    34561 tcaaaaacca actgcaacaa gtgttgtagc tgatattgtc cgtatcgttc gtcgtttgaa
    34621 tgatggtact attggcaaag acttcaacga atatagccgt gacttggtct tggcaaatcc
    34681 tgaagatgtc aaagcaaact actatttctc aatcttggct ccagactcaa aaggtcaggt
    34741 cttgaagttg gctgaaatct tcaatgctca agatatttcc tttaagcaaa tccttcaaga
    34801 tggcaaagag ggtgacaagg cgcgtgtcgt tatcatcaca cacaagatta ataaagccca
    34861 gcttgaaaat gtctcagctg aattgaagaa ggtttcagaa ttcgacctct tgaatacctt
    34921 caaggtgcta ggagaataag atgaagatta ttgtacctgc aaccagtgcc aatatcgggc
    34981 caggttttga ctcggtcggt gtagctgtaa ccaagtatct tcaaattgag gtctgcgaag
    35041 aacgagatga gtggctgatt gaacaccaga ttggcaaatg gattccacat gatgagcgta
    35101 atctcttgct caaaatcgct ttacaaattg taccagactt gcaaccaaga cgcttgaaaa
    35161 tgaccagtga tgtccctttg gcgcgcggtt tgggttcttc cagctcggtt atcgttgctg
    35221 ggattgaact agccaaccaa ctgggtcaac tcaacttatc agaccatgaa aaattgcagt
    35281 tagcgaccaa gattgaaggg catcctgaca atgtggctcc agccatttat ggtaatctcg
    35341 ttattgcaag ttctgttgaa gggcaagtct ctgctatcgt agcagacttt ccagagtgtg
    35401 attttctagc ttacattcca aactatgaat tacgtactcg cgacagccgt agtgtcttgc
    35461 ctaaaaaatt gtcttataag gaagctgttg ctgcaagttc tatcgccaat gtagcggttg
    35521 ctgccttgtt ggcaggagac atggtgaccg ctgggcaagc aatcgaggga gacctcttcc
    35581 atgagcgcta tcgtcaggac ttggtaagag aatttgcgat gattaagcaa gtgaccaaag
    35641 aaaatggggc ctatgcaacc tacctttctg gtgctgggcc gacagttatg gttctggctt
    35701 ctcatgacaa gatgccaaca attaaggcag aattggaaaa gcaacctttc aaaggaaaac
    35761 tgcatgactt gagagttgat acccaaggtg tccgtgtaga agcaaaataa agaatagaag
    35821 ataggatggg gaaactcttg accagagggt ttcatatcct ttttgtgaaa agaagtttat
    35881 actcaatgaa aatcaaagag caaactagga agctagccgc aggctgctca aaacagtgtt
    35941 ttgaggttgc agatagaact gacgaagtca gtaacatata tacggtaagg tgacgctgac
    36001 gtggtttgaa gagattttcg aagagtatta gttaaaaacg tgataaagga gaaataaaga
    36061 tggcagaaat ttatctagca ggtggttgtt tttggggcct agaggaatat ttttcacgca
    36121 tttctggagt gctagaaacc agtgttggct acgctaatgg tcaagtcgaa acgaccaatt
    36181 accagttgat caaggaaaca gaccatgcag aaacggtcca agtgatttac gatgagaagg
    36241 aagtgtcact cagagagatt ttactttatt atttccgagt tatcgatcct ctatctatca
    36301 atcaacaagg gaatgaccgt ggtcgccaat atcgaactgg gatttattat caggatgaag
    36361 cagatttgcc agctatctac acagtggtac aggagcagga acgcatgctg ggtcgaaaga
    36421 ttgcagtaga agtggagcaa ttacgccact acattctggc tgaagactac caccaagatt
    36481 atctcaggaa gaatccttca ggttactgtc atatcgatgt gaccgatgct gataagccat
    36541 tgattgatgc agcaaactat gaaaagccta gtcaagaggt gttgaaggcc agtctatctg
    36601 aagagtctta tcgtgtcaca caagaagctg ctacagaggc tccatttacc aatgcctatg
    36661 accaaacctt tgaagagggg atttatgtag atattacgac aggtgagcca ctcttttttg
    36721 ccaaggataa gtttgcttca ggttgtggtt ggccaagttt tagccgtccg atttccaaag
    36781 agttgattca ttattacaag gatctgagcc atggaatgga gcgaattgaa gttcgttctc
    36841 gttcaggcag tgctcacttg ggtcatgttt tcacagatgg accgcgggag ttaggcggcc
    36901 tccgttactg tatcaattct gcttctttac gctttgtggc caaggatgag atggaaaaag
    36961 caggatatgg ctatctattg ccttacttaa acaaataaaa cagagagtgg ggcttcccac
    37021 tttcttcatt tctagaatat gaatagaagg gatttatgaa acacctatta tcttacttca
    37081 aaccctacat caaggaatca attttagccc ccttgttcaa gctgttagaa gctgtttttg
    37141 agctcttggt tcccatggtg attgctggga ttgttgacca atctttacct cagggagatc
    37201 aaggtcatct ctggatgcag attggcctgc tccttatctt tgcagtaatt ggcgttttag
    37261 tggccttgat agctcaattt tactcagcaa aggcagcagt aggttttgct aaggaattga
    37321 caaacgatct ttatcgtcat attctttcct tgcccaagga cagcagagac cgtctgacaa
    37381 catctagttt ggtcactcgc ttgacttcgg atacctacca gattcagact ggtatcaatc
    37441 aattcctgcg tctctttttg cgagcgccca ttatcgtttt tggtgccatt tttatggctt
    37501 atcgaatctc aactgagttg actttctggt tcttagtcat ggttgccatt ttgaccattg
    37561 tcattgtagg gttatctcga ttggtcaatc ctctctacag tagtctcaga aagaaaacgg
    37621 accaactggt tcaggaaacg cgccagcaat tgcaagggat gcgggttatt cgtgcttttg
    37681 gtcaagaaaa acgagagtta cagatttttc aaacccttaa ccaagtttat gctagattac
    37741 aagaaaagac aggtttctgg tctagtttat taacacctct gacctatctg attgtcaatg
    37801 gaactcttct cgttattatc tggcaaggct atatttcaat tcaaggagga gtgctcagtc
    37861 aaggtgctct cattgctctt atcaattacc tcttacagat tttggtggaa ttggtcaagc
    37921 tagccatgtt gatcaattcc ctcaaccagt cctatatctc agtcaagcga atcgaggaag
    37981 tctttgttga ggctccagag gatatccatt cagagttaga acaaaagcaa gctaccagag
    38041 ataaggtttt acaagtccaa gaattgactt ttacctatcc tgatgcggcc cagccttctc
    38101 tgagatacat ttcctttgat atgactcaag gacaaattct aggtatcatc gggggaactg
    38161 gttctggtaa atcaagcttg gtgcaactct tacttggact ttatccagta gacaagggga
    38221 acattgacct ttatcaaaat ggacgtagtc ctcttaattt ggagcagtgg cggtcttgga
    38281 ttgcctatgt acctcaaaag gtcgaactct ttaaaggaac cattcgttcc aacttgactc
    38341 taggtttcaa tcaagaagta tctgaccagg aactctggca ggccttggag attgcgcaag
    38401 ctaaggattt tgtcagtgaa aaggaaggac tcttggatgc tctagttgag gcaggggggc
    38461 gaaatttctc aggtggacaa aaacaaagat tgtctatcgc ccgagcagtc ttgcgccaag
    38521 ctccgtttct catcctagat gatgcaacct cggcactgga taccattaca gagtccaagc
    38581 tcttgaaagc tattagagaa aattttccaa acacgagctt aattttgatc tctcaacgaa
    38641 cctcaacttt acagatggcg gaccagattc tcctcttgga aaaaggtgag ttgctagctg
    38701 ttggcaagca cgatgacttg atgaaatcca gccaagtcta ttgtgaaatc aatgcatccc
    38761 aacatggaaa ggaggactag aatgaaacga caaactgtaa accagacgct caaacgttta
    38821 gccgtagatt tagcaagcca tcctttcctc cttttcctag cctttctagg aactattgct
    38881 caagttggct tatcaattta cctacctatt ctgattgggc aggtcattga ccaagtccta
    38941 gtggctggtt catcaccagt tttttggcag atttttctcc agatgctctt ggtggtaata
    39001 ggaaatactc tggtacaatg ggccaatcct ctcctctata atcgtctaat cttctcttat
    39061 accagagatt tacgggagcg aatcatccat aagctccatc gtttaccgat tgcctttgta
    39121 gataggcaag gtagtggaga gatggttagt cgtgtaacca cggacatcga acagttggca
    39181 gctggcttga ccatgatttt taaccaattt ttcattggtg ttttgatgat tttggtcagt
    39241 attctagcca tgctccaaat tcatctcctc atgactctct tagtcttgct gttgacgcca
    39301 ctgtccatgg tgatttcacg ctttattgcc aagaaatcct atcatctctt ccagaagcaa
    39361 acagagacga ggggaattca gactcagttg attgaagaat cgcttagtca gcagactata
    39421 atccagtcct tcaatgctca aacagaattt atccaaagat tgcgtgaggc tcatgacaac
    39481 tactcaggct attctcagtc agccatcttt tattcttcaa cggtcaatcc ttcgactcgc
    39541 tttgtaaatg cactcattta tgccctttta gctggagtag gagcttatcg tatcatgatg
    39601 ggttcagcct tgaccgtcgg tcgtttagtg acttttttga actatgttca gcaatacacc
    39661 aagcccttta acgatatttc ttcagtgcta gctgagttgc aaagtgctct ggcttgcgta
    39721 gagcgtatct atggagtctt agatagccct gaagtggctg aaacaggtaa ggaagtcttg
    39781 acgaccagtg accaagttaa gggagctatt tcctttaaac atgtctcttt tggctaccat
    39841 cctgaaaaaa ttttgattaa ggacttgtct atcgatattc cagctggtag taaggtagcc
    39901 atcgttggtc cgacaggtgc tggaaaatca actcttatca atctccttat gcgtttttat
    39961 cccattagct cgggagatat cttgctggat gggcaatcca tttatgatta tacacgagta
    40021 tcattgagac agcagtttgg tatggtgctt caagaaacct ggctcacaca agggaccatt
    40081 catgataata ttgcctttgg caatcctgaa gccagtcgag agcaagtaat tgctgctgcc
    40141 aaagcagcta atgcagactt tttcatccaa cagttgccac agggatacga taccaagttg
    40201 gaaaatgctg gagaatctct ctctgtcggc caagctcagc tcttgaccat agcccgagtc
    40261 tttctggcta ttccaaagat tcttatctta gacgaggcaa cttcttccat tgatacacgg
    40321 acagaagtgc tggtacagga tgcctttgca aaactcatga agggccgcac aagtttcatc
    40381 attgctcacc gtttgtcaac cattcaggat gcggatttaa ttcttgtctt agtagatggt
    40441 gatattgttg aatatggtaa ccatcaagaa ctcatggata gaaagggtaa gtattaccaa
    40501 atgcaaaaag ctgcggcttt tagttctgaa taagccattc tcttttgaaa gtttatggac
    40561 gaaaaaagtt gccttcgagt gacttttttg ttacaatagc tagaaaaatt gttcactgta
    40621 atactcaatg aaaatcaaag agcaaactag gaagctagcc gtaggttgct caaagcacag
    40681 ctttgaggtt gtagataaga ctgacgaagt cagttcaaaa cactgttttg aggttgcaga
    40741 tagaactgac gaagtcagct caaaacactg ttttgaggtt gcagatagaa ctgacgaagt
    40801 cagtaaccac acctacggca aagtgaatct gaagtggttt gaagagagta caacttgtct
    40861 tttagaaaag gagcctataa tgaaagtctt tcagcatgta aatatcgtga cttgtgatca
    40921 agatttccat gtttatcttg atggaatctt agcagtcaag gattctcaaa tcgtctatgt
    40981 cggtcaagat aagccagcgt ttttagagca agctgagcag attatagact atcagggagc
    41041 ttggattatg cctggtttgg tcaattgtca cacccattct gcaatgacag gtctgagagg
    41101 gatccgagat gacagcaatc tccatgaatg gctcaatgac tatatttggc cagcagaatc
    41161 tgagtttact cccgacatga ctaccaatgc ggtcaaagaa gccctgacag agatgctcca
    41221 gtcaggaaca acaaccttta acgatatgta taatcccaat ggtgtggata tccagcaaat
    41281 ttatcaggtg gtgaaaactt ccaagatgcg ttgttatttt tctccgactc tcttttcttc
    41341 agagacagaa acaactgctg agactataag tagaactcga tccatcatag acgaaatctt
    41401 aaaatataaa aatccaaatt tcaaggttat ggtagcacct cattctccgt atagctgcag
    41461 tagagacttg ctggaagcga gtttggaaat ggcaaaagag ctaaatattc cgctccatgt
    41521 ccatgtggcg gagaccaagg aggagtcagg aattatcctc aaacgatacg gcaaacgccc
    41581 ccttgctttt cttgaagaac tgggttattt agatcatccg tccgtatttg ctcacggggt
    41641 cgaattaaac gagagagaaa ttgaacgctt ggcatcttct caagtggcta tcgcccacaa
    41701 tcctatcagt aacctcaaac tggcatcagg aattgctcca attatccagc tccaaaaagc
    41761 gggagtagca gtcggaattg cgactgactc ggttgcttcc aataacaatc tagatatgtt
    41821 tgaggaagga aggactgcag ctcttcttca gaagatgaaa agtggggatg ccagccagtt
    41881 tccaatcgaa acagctctca aggtactgac aatcgaaggg gctaaggtcc ttggaatgga
    41941 aaatcagata ggaagtctgg aagtcggcaa gcaagcagat tttctggtca ttcaaccaca
    42001 agggaaaatt catctccaac ctcaggaaaa tatgctgtct cacctggttt atgcagttaa
    42061 atctagtgat gtagatgatg tttatatcgc cggagaacag gttgttaagc aaggtcaagt
    42121 cctgacagta gaactttaaa agaaaaatta cgaaaaattt taaaaaaagt ttgcaaaaat
    42181 cttgcattct ttttttgact atgctatact tatatacggt ttaaaaaaac tgcctaagac
    42241 agtaggggag ctcgactcat aaatatccta ccgaggacaa aacgtatcat gtaaaaagaa
    42301 gcgtattgta ctttcgtgtc taggtttggg cgcgtttttc tttttgaaaa attccccaag
    42361 caaaataatt acggaggtga acacactaat gagtgaagca attattgcta aaaaagcgga
    42421 actagttgac gtagtagctg aaaaaatgaa agctgctgca tctatcgtcg ttgtagacgc
    42481 tcgtggtttg acagttgagc aagatacagt tcttcgtcgt gagcttcgtg gaagcgaagt
    42541 tgagtataaa gttattaaaa actcaatctt gcgtcgtgca gctgaaaaag ctggtcttga
    42601 agatcttgca tctgtatttg ttggaccatc tgcagtagca ttttctaatg aagatgttat
    42661 cgcaccagcg aaaatcttga acgacttttc taaaaacgct gaagcacttg aaattaaagg
    42721 tggtgcaatc gaaggcgctg tcgcatctaa agaagagatt cttgcacttg caactcttcc
    42781 aaaccgcgaa ggacttcttt ctatgctcct ttctgtactt caagcaccag tgcgcaacgt
    42841 tgctcttgca gtcaaagcgg ttgcagaaag caaagaagac gcggcttaat cttaagctac
    42901 acagcgtagc ctagctacga aaaaaactat tataaaattt aaaacttatt tggaggaaat
    42961 aacaatggca ttgaacattg aaaacattat tgctgaaatt aaagaagctt caatccttga
    43021 attgaacgac cttgtaaaag ctatcgaaga agaatttggt gtaactgcag ctgctcctgt
    43081 agctgttgct gcagctgatg cagctgatgc tggtgctgct aaagattcat tcgacgttga
    43141 attgacatct gcaggcgaca aaaaagttgg cgttatcaaa gttgtacgtg aaatcactgg
    43201 tcttggtctt aaagaagcta aagaacttgt tgacggtgca ccagcacttg ttaaagaagg
    43261 cgttgcaact gcagaagctg aagaaatcaa agctaaattg gaagaagctg gagcttcagt
    43321 tactcttaaa taatagagta tcgcaatttg attgcggaat ccctatttac cagtctttga
    43381 gagcgataag cgattgatag aaactgataa attgatttgg tttcctgcca aaaattcttt
    43441 ggcaggattt ttgttttaat aaactttcgg gggtagacac tagattgtct accccttttt
    43501 ttgtgtttcg gaggtaatta tgcaaaagga aggacagtca tcacgtcaat tcgtgaagag
    43561 tcatctcatg actatcatgg gagttgatat tgtaaaagca actcagttag ttgatgaaat
    43621 ggaacaagta ggtttaatcc gatttgatga atttggaaat gttggaattt tagtcttgga
    43681 gggacaataa tgaagcgtat taccgctaat caatatcaga catcagagcg ttattataag
    43741 ctccccaaac ttttatttga gagtgaacgg tataagaata tgaaactgga ggttaaggtg
    43801 gtttactcag ttttaaaaga tcggttggag ttgtctttga gcaaaggttg gattgatgag
    43861 gatggggcta tttatttgat ttattccaat tcaaatttga tggcactttt aggctgttca
    43921 aagtcaaaat tactctccat gtgagtttga agtgatattt ttagatgatt accataaaaa
    43981 acataactac ccactatttt acgaatccta tcttcaaaac gttatggaat tccttgaaag
    44041 tcaagacata aagaatgggg ttgatgcctt tgtagatgat catcaaaatc tcgtttttgt
    44101 tttatatgga caaggctatc gagccgaggg aaaagaggga atacttacaa cccaagtaac
    44161 tgtaaaagct tatgatgaag acaagaaacc gattaacttc gcaaatttat tagattcctt
    44221 aatttattag attccttaat cgtgtcagaa tatcaaatgg aaccgaatct ttgggaggtc
    44281 tcccatgatt gatctctatc taagtaaaaa tagacaaaga aatcaacttc ttttagattt
    44341 cttccaaaac tatggcatag aggtatcttg tcattcagtt tctgaaatga caaaggacaa
    44401 attaattgag atgatgagct attcttcaga ttgttttgag tttttatctc ccaatttatt
    44461 acgatttaag aaccgtgaca atctaagatt aacggatttc gttgagataa ttttaaaaaa
    44521 tcctgaacta accatcagac ttcctcttgc ggtttcaaat aagcgagttt atccaagtct
    44581 gaatttggaa gaggctagag ctctattgcc aagagatacg aaacaattga tttacatggc
    44641 gcaaacacat tatttatcta actaaaggag aagcaatatg gctgaacgat tttgggagaa
    44701 cttgtccatt attttggctg aaagaaatat cagctggatt gagttaacca gaaaaatgtt
    44761 tgcgggagag tttcactatc caagtgaatt gaatcgtttg tatcaaaaga ttcgccacta
    44821 gaagatggaa caatgaatgc ctcaaagtcc atgggtagaa aggattgtgc aggtattaga
    44881 tttagattat gaagatttat ttcggaggta actatgaaaa gaataattcc agtttatata
    44941 ttccaacaag taaatgtcct attggtatct ctatacttct ttgtatcggt gagttaacta
    45001 tactacagat tctctatggt tcgtcactca tttctttttt atggatgtat ggccaacgca
    45061 aacaagcgca taaggtcaat atgaaatcta ggatgaaatg gcttggtgtt gaatttgtta
    45121 gcctactgat tataagtcta tgttttagtc tgattcatgc tcaaggaagc acgaatcaag
    45181 caaacttaat tggccttcaa catcaaattc cttggttttc atttttattg ttcttaatca
    45241 atgcgagtat ggttgaagaa tttctgtatc gagaaatttt atggaatttg gtcagaaaat
    45301 tagatatcag agttgctttg acaagtgttt tatttgcctt agcacatcat ccaggaacca
    45361 ttatagcttg gtgtttgtat gtatcgctgg ggatgttttt agggcttgta cgctacaaat
    45421 tggacttatg gggcagtatg gggctacatt tggtgtggag cctactagtt tatagtttgc
    45481 tgctttttta aaataggtaa cctgattttt aggtaacttc taaaactaac ttccagtttt
    45541 gggagagaga tggaagttac tttgaaaagt tacggaaaca ttattttcta cgtgacaaca
    45601 ttgtatcatt gcttgcattt tactgctgga gagagtataa tgaaggtgga taaagcactt
    45661 aatcccaaaa atttaaatag gaggagttag ctatggcaga agaagtatta aatcttcaat
    45721 tagtatctgt tcaagttgac gaaacagatg aagttgatgg aatgcgattt agtacattca
    45781 gtacaaaccg ttgcggtaac tggagtgctt ttagttggga aaattgttaa ttcatttaaa
    45841 ttgtaaactt tagggattct ctggagttat ggatctcgtt ccaatatgtg cacgttggaa
    45901 tgtcagtgct tatatggggg gaatccaaag gattctccct ttttatttta ataagtctgt
    45961 ctagctatag atatattaag tttgatagaa tttcttggag attttgttat ggattataat
    46021 ttcaatttgg agcatccttt ctttttcact aataatgatt atagtacaga tactagcata
    46081 aagtactaag taagtctgcc ttttaattgg cacgaagtaa tgaataatga tgagtgggtt
    46141 tatcaatacc ctattggaaa atttgttgaa agacaagggt ggaaaataca cattagttca
    46201 gagtataata gttcacacga attgttacaa gatgtagcaa aaatttgcca tgaaatgcga
    46261 attccattta aacatcttag tacagaagac aaatttatca tgcgaaacgg gaaattggtt
    46321 agtcgaggat tttctggtaa atttattaca tgttatccaa atcaaaatga attagagtcg
    46381 gttttgcaaa ggttagaaag tgccttaaag caatataatg ggccatatat tttaagcgat
    46441 aaacgttggg atgaagcacc aatatatctg aggtatggtg tgtttaggcc gtcaagggat
    46501 gatgaaaaga aggttgttat tgatgaatta attgttggcg atgaagttgt taaagatgaa
    46561 cgtttaccag tatttaaaat tccaaaaggt atagtgcccc ctgacttttt gaataaatgg
    46621 cttgacaaga aagataaaaa acagggagac tttcccttta ttatagataa tgcaattaga
    46681 ttttcaagca gtggtgggat atataatgct agactaaaag aagatgggaa aaaaataatt
    46741 ttaaaagagg ctagaccgta tacaggtcta ggatttgatg gtacttattc ttcagagaga
    46801 ttagcttcgg agtgcaaagc actaaaaatt ctaaatgaat ggagtgagat gcctaaaata
    46861 tactggtacg gtaagatctg ggagcacacc ttcttaggaa ttgaacatat gaagggcgtt
    46921 ccactaaata gatgggttac caataatttt cctttatatg aagttgttga taagaccaaa
    46981 gattatctat tgagagtttc aaagatagta gaaaaactca tcgatttaac gaataagttt
    47041 cattctgaaa atgtatatca tcaagattta catttaggaa atatcttggt taaggatgaa
    47101 gatgagatta gtataataga ctgggaacag gctgtctttt cgaatgatga aaaagttgta
    47161 cataaagttg cagcccctgg ttttagagca tggcgagaaa cacttcccag tgagatagat
    47221 tggtatggta ttagacaaat agctcattat ttatacatgc cactagtaac tacatcggat
    47281 ttgacataca actatgtaag tcaaaccagg atagaaggaa aaaaactatt tgagtctttg
    47341 ggttatacaa gagaacatat agattatgta gaaagtttat tgtcatatct agattctaaa
    47401 tgtccacaga ttgagaatat ttccaggaaa aaagttttaa aacccatgca tgagattaga
    47461 actatcgaga gtgagcaaga tatacaagat tttattataa aagcttttct tttagtgaac
    47521 tgataggtat tttcttagca aacgataaag ttttagggcc gatacaatca attgcctatt
    47581 cattaaataa gataaataca accaaagatt taaggaaacc gtttttaaaa tacttaagtg
    47641 gagagaagaa ttttatagac gctgaacatg ataataacgg actgtatact tcatcaatag
    47701 atgtgataca catgaaagat gttgtatatt ctattacacc agaaaataaa ttaagtattg
    47761 acttctcatt taagtcacca tttagggtat tattaacagg aacttctggt agtgggaaaa
    47821 caacgatttt aaatttaatt aatggttctt taaagccaca aaaaggttat gtaaatttgt
    47881 tatcacatgg gaaaaagagt tcagattcaa taccaacagt tgatcagaca ccatatattt
    47941 ttgacactac tattcgtgag aacgtaactt tatttcaaaa tgaatatttt tcagatgatc
    48001 agataattga ggtgttaaaa aaggtaaatc tatatgaaga attagaaaag atagatatac
    48061 taaattatca atgtggtgaa aatggtagta atttgtctgg aggtcaaaaa caaaaaatag
    48121 ctttagctag agctctgatt agaaataata aagtgtactt atttgacgaa atatcagcta
    48181 atttagataa tgataattca aattccatac atgatattct gttcaattta ggtatttcat
    48241 ttattgaagt ttcacatcat tatgacttaa atgacaagag atacactgat atataaattg
    48301 gaaaatggaa cacttttcaa aattaagtga ttggaggcaa gaatatggat aaagattata
    48361 tattaaaagt gaaagggctg tatcatcaat ttttactggg aaacaataaa acgttgcaag
    48421 tgctgaaaaa tgtttctctt tctgcttcga gaggagaatt tataagtatt ctaggaatta
    48481 gtggttctgg aaagtcaact ttattaaaat gtatttctag tttgcttgaa ccaacaagtg
    48541 gggaagtaat tttaaatgga atcaacccct ataaaatcag aaatgcaaaa ttgtcaagta
    48601 taagacgtaa cgaagtatct tttatatttc aagcatacaa tttaatacct tccctgccgg
    48661 taatagaaaa tatagcactt cctttgcgat tatcacaaaa aaaattaact attaaaaatg
    48721 tagaaaactt actcaaaaga atgaagttta atgctggctt aaacgatttt gttggaactc
    48781 tgtctggtgg agaacaacag aaggttgcta tagctagagc ggttattgct gatagtgata
    48841 taatatttgc tgatgagcca actggggctt tagacagcgt ttctcgtgaa gtaatttttg
    48901 aattattgag agagttagta ggggcgggta agtgtgtaat tatggtaacg cacgatatag
    48961 aattggcctc gaaaactgat cgtgcattaa tattgaaaga tggaaaaatt ttcaaagaac
    49021 ttcatagacc tagcggggaa gagttgtata aaatcttaga ggtacaatca actacggagg
    49081 aatagagatg ctcagattag tttactatca atttttacat aataagaaac aatggttagg
    49141 cgtttcacca gtaatttttg tttcgagttt agttatggga ttggctgtta atggggtaat
    49201 taatgttgag aataattcgc aagtatttgt cggacttcca gatcctaaac caatttttat
    49261 gtttccgata gtattcggag gagtaacatt attctttgtg ctctctaaca taataaatat
    49321 gttggttgaa atttttagag atgattacga acttctggag gtgttgggag caagtctcct
    49381 tcaactatca tttcttgtgg ggggacagat ttttatcatt tcctcgatta ttagttttat
    49441 tgcatatcta tgctctatat ttgttacgtc aaattattat tattttttac aatacttttt
    49501 cggggaaaat atattacctg atatccaatt tcaaacgagt gctgttggat gtatcattac
    49561 agtagtgttg atttcatttt tagcctttct aagtggttgc ttttatacgt tcaagaagat
    49621 tagaaatagg aagagttcta aaataaggca tgttctttca atagtaaaaa gaatactgct
    49681 attggctggt tttagtgtta tctggttgct ttctttgcaa caaattttcc aagatagcac
    49741 aattttagcg aaggcccaga taatattcaa tattgtaatc ttagatattg tgattattta
    49801 tcaattatct ccttttatac agtcatgttt tatcaaacta ctttctataa ttatatttag
    49861 aaataatttt atgttcattg tttcgaagtg gaatttacta tatcgtaagc cttatataaa
    49921 atctatcagt gctgcaatta caggagctat attactaatt tctagttttc aaatgatttc
    49981 tcagaatata ctatctcaat ttcaagatga cagtgattta gagctaaaag tggcatttat
    50041 tgtctatgta ggagcaccaa ttttgatagt acttgcaaat attatttcaa ttgcattttt
    50101 gtcatcgcat caagaaagga ttgagattca gcaatttgaa attttaggaa cttctaatta
    50161 ccagatggtt aagattaaag ttggtgaggc tatatttttg acatttgtta cttcattaat
    50221 tgcattttta cttaacatta aaattatggc tttaatatac tactctttag gggatatttt
    50281 aatagatgat atgaatcttt tggggttaat acttccaaat tttatagtgt ctattatttt
    50341 atttatttta atatttatta ctaaaagttc ctattttatc tttaagaatg caaaaattat
    50401 ttcttaaaaa tttgtaagtt ttcgctatat aaaatagtta aatctatttt gtatcattgc
    50461 ttgcatttta ctggtggaga gaatataatg agggtggata aagtacttaa tcccaaaaat
    50521 ttaaatagga ggagctagct atggcagaag aagtattaaa tcttcaatta gtatctgttc
    50581 aagttgacga aacagatgaa gttgatggaa tgcgatttag tacattcagt acaaaccgtt
    50641 gcggtaactg gagtgctttt agttgggaaa attgttaat
//
LOCUS       DBMVGT010000007        47788 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.007, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000007 DBMVGT010000000
VERSION     DBMVGT010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 47788)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47788)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47788
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.007"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..259)
                     /locus_tag="AC0DU4_000436"
     CDS             complement(<1..259)
                     /locus_tag="AC0DU4_000436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236450.1"
                     /translation="MNDEASKQLTDARFKRLVGVQRTTFEEMLAVLKTAYQLKHAKGG
                     RKPKLSLEDLLMATLQYVREYRTYEEIAADFGVHESNLLRRS"
     gene            complement(267..708)
                     /locus_tag="AC0DU4_000437"
                     /pseudo
     CDS             complement(267..708)
                     /locus_tag="AC0DU4_000437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000335618.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
     gene            complement(710..1747)
                     /locus_tag="AC0DU4_000438"
     CDS             complement(710..1747)
                     /locus_tag="AC0DU4_000438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M42 family metallopeptidase"
                     /protein_id="HIN4236451.1"
                     /translation="MNQTINYIKELTAIASPTGFTREISDYLVHTLEKLGYQPVRTAK
                     GGVNVTIKGQNDEQQRYVTAHVDTLGAIVRAVKPDGRLKLDRIGGFPWNMIEGENCTV
                     HVASTGQTVSGTILIHQTSCHVYKDAGTAERTQDNMEVRLDAKVTNEKETRALGIEVG
                     DFISFDPRTVVTETGFIKSRHLDDKVSAAILLNLLRVYKEEGIELPVTTHFAFSVFEE
                     VGHGANSNIPTQVVEYLAVDMGAMGDDQQTDEYTVSICVKDASGPYHYDFRQHLVALA
                     KEQDIPFKLDIYPFYGSDASAAMSAGAEVKHALLGAGIESSHSYERTHIDSVVATERM
                     VDAYLRSNLVD"
     gene            complement(1845..3170)
                     /gene="brnQ"
                     /locus_tag="AC0DU4_000439"
     CDS             complement(1845..3170)
                     /gene="brnQ"
                     /locus_tag="AC0DU4_000439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006152071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015658 - branched-chain amino acid
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0015803 - branched-chain amino acid
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HIN4236452.1"
                     /translation="MAKKGTLTGLLLFGIFFGAGNLIFPPSLGALSGEHFLPAIAGFV
                     FSGVGIAVLTLIIGTLNPKGYIYEISTKIAPWFATLYLSVLYLSIGPFFATPRTATTA
                     YEVGISPLLSDANKGLGLIVFTVLYFAVAYLISLNPSKILDRIGRILTPVFAILIVIL
                     VVLGAIKYGGTSPQAASAAYQASAFGTGFLEGYNTLDALASVAFSVIAVQTLKQLGFS
                     SKKEYISTIWVVGIVVALAFSALYIGLGFLGNHFPVPAEAMKGGTPGVYILSQATQEI
                     FGSTAQLFLAAMVTVTCFTTTVGLIVSTAEFFNERFPQISYKVYATAFTLIGFAIANL
                     GLDAIIKYSIPVLVILYPITIAIVMIVIVNKFVALSKPGMQLTIAVVTVIAIASVLGS
                     SFKVEFLANLVSVLPFAKASLPWLVPAIVGILLSLVLPNKQESDVFEME"
     gene            complement(3341..3628)
                     /locus_tag="AC0DU4_000440"
                     /pseudo
     CDS             complement(3341..3628)
                     /locus_tag="AC0DU4_000440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658232.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
     gene            complement(3788..4366)
                     /locus_tag="AC0DU4_000441"
     CDS             complement(3788..4366)
                     /locus_tag="AC0DU4_000441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HIN4236453.1"
                     /translation="MSQIERIKQAIMADSQNASYTERGIEPLFVAPKTARINIIGQAP
                     GLKTQEADLYWKDKSGDRLRDWLGVDEDTFYNSGYFAVLPMDFYFPGHGKSGDLPPRT
                     DFAEKWHPQLLQELPDIQLTLLIGQYAQAYYLQEKISGKVTERVKHYKDYLPAYFPLV
                     HPSPRNQIWMSKNPWFEAEVVPDLKKRIKTIL"
     gene            complement(4420..5820)
                     /gene="pepV"
                     /locus_tag="AC0DU4_000442"
     CDS             complement(4420..5820)
                     /gene="pepV"
                     /locus_tag="AC0DU4_000442"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004151 - dihydroorotase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HIN4236454.1"
                     /translation="MIAIDFTAEVEKRKEDLLADLFSLLEINSERDDSKADAQHPFGP
                     GPVKALEKFLEIADRDGYPTKNVDNYAGHFEFGDGEEVLGIFAHMDVVPAGSGWDTDP
                     YTPTIKDGRLYARGASDDKGPTTACYYGLKIIKELGLPTSKKVRFIVGTDEESGWADM
                     DYYFEHVGLAKPDFGFSPDAEFPIINGEKGNITEYLHFAGENTGAARLHSFTGGLREN
                     MVPESATAVVSGDLADLQAKLDAFVAEHKLRGELQEEAGKYKVTIIGKSAHGAMPASG
                     VNGATYLALFLSQFDFAGPAKEYLDITGKILLNDHEGESLKIAHVDEKMGALSMNAGV
                     FRFDETCADNTIALNIRYPKGTSPEQIKSILENLPVASVSLSEHGHTPHYVPMEDPLV
                     QTLLNVYEKQTGLQGHEQVIGGGTFGRLLERGVAYGAMFPDSIDTMHQANEFIALDDL
                     FRAAAIYAEAIYELIK"
     gene            complement(5833..6438)
                     /locus_tag="AC0DU4_000443"
     CDS             complement(5833..6438)
                     /locus_tag="AC0DU4_000443"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002924506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HIN4236455.1"
                     /translation="MKFLELNKKRHATKHFTDKPVDPKDVRTAIEIATLAPSAHNSQP
                     WKFVVVCEKNAELAKLAYGSNFEQVSSAPVTIALFTDTDLAKRARKIARVGGANNFSE
                     EQLQYFMKNLPAEFARYNEQQVSDYLALNAGLVAMNLVLALTDQGIGSNIILGFDKSK
                     VNEVLEIEDRFRPELLITVGYTDDKLEPSYRLPVDEIIEKR"
     gene            6609..7409
                     /locus_tag="AC0DU4_000444"
                     /pseudo
     CDS             6609..7409
                     /locus_tag="AC0DU4_000444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714621.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
     gene            complement(7587..8420)
                     /locus_tag="AC0DU4_000445"
     CDS             complement(7587..8420)
                     /locus_tag="AC0DU4_000445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001015777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HIN4236456.1"
                     /translation="MNHKIAILSDVHGNATALEAVIADAKNQGASEYWLQGDIFLPGP
                     GANDLVALLKDLPITASVRGNWDDRVLEVLDGEYGLEYPKEIQSMRMTQFLMERMDPA
                     TIVWLRSLPLLEKKEIDGLRFSISHNLPDKNYGGDLLVENDTEKFDQLLDAETDVAVY
                     GHVHKQLLRYGSKGQQIINPGSIGMPYFNWEALKNHRAQYAVIEVEDGELLNIQFRKV
                     AYDYEAELELAKSKGLPFIEMYEELRREDNYQRHNLKLLASLIEKHRYVEDVKNFFDF
                     L"
     gene            complement(8410..10254)
                     /gene="uvrC"
                     /locus_tag="AC0DU4_000446"
     CDS             complement(8410..10254)
                     /gene="uvrC"
                     /locus_tag="AC0DU4_000446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009380 - excinuclease repair complex
                     [Evidence IEA];
                     GO_function: GO:0009381 - excinuclease ABC activity
                     [Evidence IEA];
                     GO_process: GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HIN4236457.1"
                     /translation="MNNLIKPKLELLPTSPGCYIYKDKNGTIIYVGKAKNLRNRVRSY
                     FRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEINLIKENKPKYNIMLKDDKSYPFI
                     KITNEHYPRLIITRQVKKDGGLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCF
                     YYHIGQCMAHTICKNDEAYFKSMAQEVSDFLKGQDDKIIDDLKSKMAVTAQSMEFERA
                     AEYRDLIQAIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNL
                     FPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKALVDTKILKPQRGEKK
                     QLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGT
                     SPVSAMVVFVNGRPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLI
                     VIDGGQGQVNIAKQVIQEELGLDIPIAGLQKNDKHQTHELLFGDPLEVVDLSRNSQEF
                     FLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMKHFKSLTKIKEA
                     SVDEIVEVGVPRVVAEAVQRKLNPQGEALPQVAEERVDYQTEGNHNEP"
     gene            complement(10293..10994)
                     /locus_tag="AC0DU4_000447"
     CDS             complement(10293..10994)
                     /locus_tag="AC0DU4_000447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001267193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M57 family metalloprotease"
                     /protein_id="HIN4236458.1"
                     /translation="MRWLFRLIGAFFSFVWRLFWRLVWIVVLLCVLAFGLLWYLNGDF
                     QGALKQAERSVKIGQQSIDQWEKTGQLPKLSQTDSHQHSEGRWPQASARIYLDPQMDS
                     RFQEAYLEAIQNWNQTGAFNFELVTESSKADITATEMNDGGTPVAGEAESQTNLLTGQ
                     FLSVTVRLNHYYLSNPYYGYSYERLVHTAEHELGHAIGLDHTDEKSVMQPAGSFYGIQ
                     EEDVANLRKIYETNE"
     gene            complement(11073..12305)
                     /gene="murN"
                     /locus_tag="AC0DU4_000448"
     CDS             complement(11073..12305)
                     /gene="murN"
                     /locus_tag="AC0DU4_000448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurN"
                     /protein_id="HIN4236459.1"
                     /translation="MALTTLTKEEFQTYSDQVSSRSFMQSVQMGDLLEKRGARIVYLA
                     LKQEGEIQVAALVYSLPMLGGLHMELNSGPIYTQQDALPVFYAELKEYAKQNGVLELL
                     VKPYETYQTFDSQGNPIDAEKKSIIQGLTDLGYQFDGLTTGYPGGEPDWLYYKDLTEL
                     TEKSLLKSFSKKGKPLVKKAETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEY
                     YEHFYDTFGEQAEFLIASLNFSDYMSKLQGEQNKLEENLDKLRLDLSKNPHSEKKQNQ
                     LREYSSQFETFEVRKAEARDLIEKYGEEDIVLAGSLFVYMPQETTYLFSGSYTEFNKF
                     YAPALLQKYVMLESIKRGIPKYNFLGIQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYH
                     PSPLKYKAIQLLKKIVGR"
     gene            complement(12310..13530)
                     /gene="murM"
                     /locus_tag="AC0DU4_000449"
     CDS             complement(12310..13530)
                     /gene="murM"
                     /locus_tag="AC0DU4_000449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurM"
                     /protein_id="HIN4236460.1"
                     /translation="MYRYQIGIPTLEYDQFVKEHELANVLQSSAWEEVKSNWQHEKFG
                     VYREEKLLATASILIRTLPLGYKMFYIPRGPILDYGDKELLNFAIQSIKSYARSKRAV
                     FVTFDPSICLSQSLINQEKTEFPENLAIIDSLQQMGVRWSGKTEEMGDTIQPRIQAKI
                     YKENFEEDKLSKSTKQAIRTARNKGLEIQYGGLELLDSFSELMKKTEKRKEIHLRNEA
                     YYKKLLDNFKDKAYITLATLDVSKRSQELEEQLAKNRALEETFTESTRTSKVEAQKKE
                     KERLLEELTFLQEYIDVGQARVPLAATLSLEFGTTSVNIYAGMDDDFKRYNAPILTWY
                     ETARYAFERGMVWQNLGGVENSLNGGLYHFKEKFNPTIEEYLGEFTMPTHPLYPLLRL
                     ALDFRKTLRKKHRK"
     gene            complement(13642..14421)
                     /locus_tag="AC0DU4_000450"
     CDS             complement(13642..14421)
                     /locus_tag="AC0DU4_000450"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HIN4236461.1"
                     /translation="MAVMKIEYYSQVLDMEWGVNVLYPDANRVEEPECEDIPVLYLLH
                     GMSGNHNSWLKRTNVERLLRGTNLIVVMPNTSNGWYTDTQYGFDYYTALAEELPQVLK
                     RFFPNMTSKREKTFIAGLSMGGYGCFKLALTTNRFSHAASFSGALSFQNFSPESQNLG
                     SPAYWRGVFGEIRDWTTSPYSLESLAKKSDKKTKLWAWCGEQDFLYEANNLAVKNLKK
                     LGFDVTYSHSAGTHEWYYWEKQLEVFLTTLPIDFKLEERLT"
     gene            complement(14490..16151)
                     /locus_tag="AC0DU4_000451"
     CDS             complement(14490..16151)
                     /locus_tag="AC0DU4_000451"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004521 - RNA endonuclease activity
                     [Evidence IEA];
                     GO_function: GO:0004534 - 5'-3' RNA exonuclease activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HIN4236462.1"
                     /translation="MSNISLTTLGGVRENGKNMYIAEIGESIFVLNVGLKYPENEQLG
                     VDVVIPNMDYLFENSDRIAGVFLTHGHADAIGALPYLLAEAKVPVFGSELTIELAKLF
                     VKGNDAVKKFNDFHVIDENTEIDFGGTVVSFFPTTYSVPESLGIVLKTSEGSIVYTGD
                     FKFDQTASESYATDFARLAEIGRDGVLALLSDSANADSNIQVASESEVRDEITQTIAD
                     WEGRIIVAAVSSNLSRIQQIFDAADKTGRRIVLTGFDIENIVRTAIRLKKLSLANEIL
                     LIKPKDMSRFEDHELIILETGRMGEPINGLRKMSIGRHRYVEIKDGDLVYIATAPSIA
                     KEAFVARVENMIYQAGGVVKLITQSLHVSGHGNVRDLQLMINLLQPKYLFPVQGEYRE
                     LDAHAKAAMAVGMLPERIFIPKKGTTMAYENGDFVPAGSVSAGDILIDGNAIGDVGNV
                     VLRDRKVLSEDGIFIVAITVNRREKKIVARARVHTRGFVYLKKSRDILRESSELINQT
                     VEDYLQGDDFDWADLKGKVRDNLTKYLFDQTKRRPAILPVVMEAK"
     gene            complement(16326..18548)
                     /gene="recJ"
                     /locus_tag="AC0DU4_000452"
     CDS             complement(16326..18548)
                     /gene="recJ"
                     /locus_tag="AC0DU4_000452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001832038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008409 - 5'-3' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HIN4236463.1"
                     /translation="MITPTYEWQFALQVEDADFTKIAKKAGLGPEVARLLFERGIQDQ
                     ESLKKFLEPSLEDLHDAYLLHDMDKAVERIRQAIEEGENILVYGDYDADGMTSASIVK
                     ESLEQLGAECRVYLPNRFTDGYGPNASVYKYFIEQEGISLIVTVDNGVAGHEAIALAQ
                     SMGVDVIVTDHHSMPETLPDAYAIVHPEHPDADYPFKYLAGCGVAFKLACALLEEVQV
                     ELLDLVAIGTIADMVSLTDENRILVQYGLEMLGHTQRIGLQEMLDMAGIAANEVTEET
                     VGFQIAPRLNALGRLDDPNPAIDLLTGFDDEEAHEIALMIHQKNEERKEIVQSIYEEA
                     KTMVDPEKKVQVLAKEGWNPGVLGIVAGRLLEELGQTVIVLNIEDGRAKGSARSVEAV
                     DIFEALDPHRDLFIAFGGHAGAAGMTLEVEQLSDLSQVLEDYVREKGADAGGKNKLNL
                     DEELDLEALSLETVKSFERLAPFGMDNQKPIFYIKNFQVESARTMGAGNAHLKLKISK
                     GEASFEVVAFGQGRWATEFSQTKNLELAVKLSVNQWNGQTALQLMMVDARVEGVQLFN
                     IRGKNAVLPEGVPVLDFPGELPNLAASEAVVVKNIPEDITQLKTIFQEQHFSAVYFKN
                     DIDKTYYLTGYGTRDQFAKLYKTIYQFPEFDIRYKLKDLAAYLNIQQILLVKMIQVFE
                     ELGFVTIKDGVMTVNKEAPKREIGESQIYQNLKQTVKDQEMMALGTVQEIYDFLMEKE
                     "
     gene            18825..19583
                     /locus_tag="AC0DU4_000453"
     CDS             18825..19583
                     /locus_tag="AC0DU4_000453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015424 - ABC-type amino acid transporter
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HIN4236464.1"
                     /translation="MVLVEFKNVEKYYGDYHALRNINLRFEKGQVVVLLGPSGSGKST
                     LIRTINGLEAVDKGSLLVNGHQVAGASQKDLVPLRKEVGMVFQHFNLYPHKTVLENVT
                     LAPIKVLGIDKKEAEKTAKKYLEFVNMWDKKDSYPAMLSGGQKQRIAIARGLAMHPEL
                     LLFDEPTSALDPETIGDVLAVMQKLARDRMNMIIVTHEMGFAREVADRIIFMADGEVL
                     VDTTDVDNFFDNPSEPRAQQFLSKIINHESDKVK"
     gene            19623..20387
                     /locus_tag="AC0DU4_000454"
     CDS             19623..20387
                     /locus_tag="AC0DU4_000454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000624332.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HIN4236465.1"
                     /translation="MISLFGLAAAKPVQADTSIADIQKRGELVVGVKQDVPNFGYKDP
                     KTGTYSGIETDLAKMVADELKVKIRYVPVTAQTRGPLLDNEQVDMDIATFTITDERKK
                     LYNFTSPYYTDASGFLVNKSAKIKKIEDLNGKTIGVAQGSITQRLITELGKKKGLKFK
                     FVELGSYPELITSLHAHRIDAFSVDRSILSGYTNKRTALLDDSFKPSDYGIVTKKSNT
                     ELNDYLDNLVTKWSKDGSLQKLYDRYKLKPSSHTAD"
     gene            20400..21077
                     /locus_tag="AC0DU4_000455"
     CDS             20400..21077
                     /locus_tag="AC0DU4_000455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HIN4236466.1"
                     /translation="MTDLSSWTAYFQDFGQFFNGFLFTLALAIGSFILAMVLGIFFGA
                     MSTSKRPILRILARIFVEFYQNTPLLVQFVIVFYGLPLISDHIIMIPIYWTAVLCVGL
                     YHGAYIAEVIRSGIQSIPSGQMEAALSQGFTYISAMRLITLPQTFRIILPPLTNQIVN
                     LIKNTSTVAIISGVDLMFVTKSWSALNGNYIPAFLGATLLYFALCFPVAQFGRKMEQA
                     NKKAYSL"
     gene            21087..21746
                     /locus_tag="AC0DU4_000456"
     CDS             21087..21746
                     /locus_tag="AC0DU4_000456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HIN4236467.1"
                     /translation="MESILEVLTPDNLVFIFKGFGLTLYISLIAIILSTIIGTVLAVM
                     RNGKNPVLRIISSIYIEFVRNVPNLLWIFTIFLVFKMKSTPAGITAFTLFTSAALAEI
                     IRGGLNAVDKGQYEAGMSQGFTSAQILYYIILPQAIRKMLPAIISQFVTVIKDTSLLY
                     SVIALQELFGASQILMGRYFEPEQVFSLCILIALIYFSFNLAISSLSHMLAKRWQQAA
                     E"
     gene            22004..23194
                     /locus_tag="AC0DU4_000457"
     CDS             22004..23194
                     /locus_tag="AC0DU4_000457"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin reductase family protein"
                     /protein_id="HIN4236468.1"
                     /translation="MKSVKGLLFIIASFILTLLTWMNTSPQFMIPGLALTSLSLTFIL
                     ATRLPLLESWFHSLEKVYTVHKFTAFLSIILLIFHNFSMGGLWGSRLAAQFGNLAIYI
                     FASIILVAYLGKYIQYEAWRWIHRLVYLAYILGLFHIYMIMGNRLLTFNLLSFLVSSY
                     ALLGLLAGFYIIFLYQKISFPYLGKITHLKRLNHDTREIQIHLSRPFNYQSGQFAFLK
                     IFQEGFESAPHPFSISGGHGQTLYFTVKNSGDHTKNIYDNLQAGSKVTLDRAYGHMII
                     EEGRENQVWIAGGIGITPFISYIREHPILDKQVHFYYSFRGDENAVYLDLLRNYAQKN
                     PNFELHLIDSTKDGYLNFEQKEVPEHATVYMCGPISMMKALAKQIKKQNPKTELIYEG
                     FKFK"
     gene            complement(23515..24396)
                     /locus_tag="AC0DU4_000458"
     CDS             complement(23515..24396)
                     /locus_tag="AC0DU4_000458"
                     /EC_number="4.1.2.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011184946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class II fructose-bisphosphate aldolase"
                     /protein_id="HIN4236469.1"
                     /translation="MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAP
                     VLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTS
                     IMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAK
                     AMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQI
                     QAAIKLGVAKVNVNTECQIAFANATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAI
                     QASVEERIDVFGSEGKA"
     gene            complement(24535..25863)
                     /gene="vncS"
                     /locus_tag="AC0DU4_000459"
     CDS             complement(24535..25863)
                     /gene="vncS"
                     /locus_tag="AC0DU4_000459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase VncS"
                     /protein_id="HIN4236470.1"
                     /translation="MKRTGLFAKIFIYTFSIFSVLVICLHLAIYFLFPSTYLSHRQET
                     IGQKATAIAQSLEGKDRQSIEQVLDLYSQTSDIKGTVKGEMTEDKLEVKDSLPLDTDR
                     QTTSLFIEEREVKTQDGGTMILQFLASMDLQKEAEQISLQFLPYTLLASFLISLLVAY
                     IYARTIVAPILEIKRVTRRMMDLDSQVRLRVDSKDEIGNLKEQINSLYQHLLTVIADL
                     HEKNEAILQLEKMKVEFLRGASHELKTPLASLKILIENMRENIGRYKDRDQYLGVALG
                     IVDELNHHVLQILSLSSVQELRDDRETIDLLQMTQNLVKDYALLAKERELQIDNSLTH
                     QQAYLNPSVMKLILSNLISNAIKHSVPGGLVRIGEREGELFIENSCSSEEQEKLAQSF
                     SDNASRKVKGSGMGLFVVKSLLEHEKLAYRFEMEENRLTFFIDFPKVVQD"
     gene            complement(25860..26516)
                     /gene="vncR"
                     /locus_tag="AC0DU4_000460"
     CDS             complement(25860..26516)
                     /gene="vncR"
                     /locus_tag="AC0DU4_000460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor VncR"
                     /protein_id="HIN4236471.1"
                     /translation="MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYE
                     VALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAFQDEEYKMSAFASLADGYLEKPF
                     SLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLV
                     KNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK
                     "
     gene            complement(26565..26648)
                     /gene="pep27"
                     /locus_tag="AC0DU4_000461"
     CDS             complement(26565..26648)
                     /gene="pep27"
                     /locus_tag="AC0DU4_000461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_198524447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative autolysis signal peptide Pep27"
                     /protein_id="HIN4236472.1"
                     /translation="MRKEFHNVLSSGQLLADKRPARDYNRK"
     gene            complement(26828..28207)
                     /gene="vex3"
                     /locus_tag="AC0DU4_000462"
     CDS             complement(26828..28207)
                     /gene="vex3"
                     /locus_tag="AC0DU4_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit Vex3"
                     /protein_id="HIN4236473.1"
                     /translation="MLHNAFAYVTRKFFKSIVIFLIILLMASLSLVGLSIKGATAKAS
                     QETFKNITNSFSMQINRRVNQGTPRGAGNIKGEDIKKITENKAIESYVKRINAIGDLT
                     GYDLIETPETKKNLTADRAKRFGSSLMITGVNDSSKEDKFVSGSYKLVEGEHLTNDDK
                     DKILLHKDLAAKHGWKVGDKVKLDSNIYDADNEKGAKETVEVTIKGLFDGHNKSAVTY
                     SQELYENTAITDIHTAAKLYGYTEDTAIYGDATFFVTADKNLDDVMKELNGISGINWK
                     SYTLVKSSSNYPALEQSISGMYKMANLLFWGSLSFSVLLLALLLSLWINARRKEVGIL
                     LSIGLKQASILGQFITESILIAIPALVSAYFLANYTARAIGNTVLANVTSGVAKQASK
                     AAQASNLGGGAEVDGFSKTLSSLDISIQTSDFIIIFVLALVLVVLVMALASSNLLRKQ
                     PKELLLDGE"
     gene            complement(28259..28906)
                     /gene="vex2"
                     /locus_tag="AC0DU4_000463"
     CDS             complement(28259..28906)
                     /gene="vex2"
                     /locus_tag="AC0DU4_000463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding subunit Vex2"
                     /protein_id="HIN4236474.1"
                     /translation="MTLLQLQDVTYRYKNTAEAVLYQINYNFEPGKFYSIIGESGAGK
                     STLLSLLAGLDSPVEGSILFQGEDIRKKGYSYHRMHHISLVFQNYNLIDYLSPLENIR
                     LVNKKASKNTLLELGLDESQIKRNVLQLSGGQQQRVAIARSLVSEAPVILADEPTGNL
                     DPKTAGDIVELLKSLAQKTGKCVIVVTHSKEVAQASDITLELKDKKLTETRNTSK"
     gene            complement(28919..30196)
                     /locus_tag="AC0DU4_000464"
     CDS             complement(28919..30196)
                     /locus_tag="AC0DU4_000464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236475.1"
                     /translation="MNPIQRSWAYVSRKRLRSFILFLILLVLLAGISACLTLMKSNKT
                     VESNLYKSLNTSFSIKKIENGQTFKLSDLASVSKIKGLENVSPELETVAKLKDKEAVT
                     GEQSVERDDLSAADNNLVSLTALEDSSKDVTFTSSAFNLKEGRHLQKGDSKKILIHEE
                     LAKKNGLSLHDKIGLDAGQSESGKGQTVEFEIIGIFSGKKQEKFTGLSSDFSENQVFT
                     DYESSQTLLGNSEAQVSAARFYVENPKEMDGLMKQVENLALENQGYQVEKENKAFEQI
                     KDSVATFQTFLTIFLYGMLIAGAGALILVLSLWLRERVYEVGILLALGKGKSSIFLQF
                     CLEVVLVSLGALLPAFVAGNAITTYLLQTLLASGDQASLQDTLAKASSLSTSILSFAE
                     SYVFLVLLSCLSVALCFLFLFRKSPKEILSSIS"
     gene            complement(30553..30723)
                     /locus_tag="AC0DU4_000465"
                     /pseudo
     CDS             complement(30553..30723)
                     /locus_tag="AC0DU4_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron maturase-specific
                     domain-containing protein"
     gene            complement(30866..31012)
                     /locus_tag="AC0DU4_000466"
     CDS             complement(30866..31012)
                     /locus_tag="AC0DU4_000466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236476.1"
                     /translation="MKEANKNHPAGAPTFAKGEGEHANDIVATYSDGTTYYVPLNDVT
                     KYAR"
     gene            complement(31009..31464)
                     /locus_tag="AC0DU4_000467"
     CDS             complement(31009..31464)
                     /locus_tag="AC0DU4_000467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001817843.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236477.1"
                     /translation="MQILCYFTITVVAKPNNSGEVHLDVSIEDNQGGSGHNFSSVSSS
                     SQTAKYEETGYNNNSSLYITIDKTSDATALLKLKLNNVDNQPATEVPSSGITVKLNAK
                     DNAGNWTSASNKKEITVKIVSAKPTYPDKILVKNPDNIKDTEKMPLLKN"
     gene            complement(31601..32485)
                     /locus_tag="AC0DU4_000468"
     CDS             complement(31601..32485)
                     /locus_tag="AC0DU4_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236478.1"
                     /translation="MRAKELQDWFPEARISDQPVEKEGYLTLPLASQQWILLEEAGLS
                     EREKQLVALLTQQEQARSLNPWYSYLVEGKGQAPQVFKKIQLVYCHLSYFQQENLASW
                     LDMMRTLFPNCQTVLQVGAQDYVFVLQQDKYTSVRDILSDTIEAVEYDFGLRLSIMLG
                     QVWSQTGHQALSDLIKAERDLFKTWWRQGHQGVHTFSQLYLWSMGERLVDLKPIKECL
                     HQMILDQDQIQEIILSLWENSAVLTKTAQQLYLHRNSLQYKIDKWEELTGLQLKELTD
                     LTLCYQLILGSLSTIVGL"
     gene            complement(32489..32875)
                     /locus_tag="AC0DU4_000469"
     CDS             complement(32489..32875)
                     /locus_tag="AC0DU4_000469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HIN4236479.1"
                     /translation="MIDVNLINGIALAFEGDAVYSMYIRRHLILKGMTKPNKLHQEAT
                     KYVSAKAQARLIALMLEEQVLTEKEEEIYKRGRNTNSHTKAKNADVVTYRMSTGFEAV
                     MGYLHMTENLERLESLVSWCIQKVEG"
     gene            complement(32868..34211)
                     /gene="cysS"
                     /locus_tag="AC0DU4_000470"
     CDS             complement(32868..34211)
                     /gene="cysS"
                     /locus_tag="AC0DU4_000470"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002916477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004817 - cysteine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006423 - cysteinyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HIN4236480.1"
                     /translation="MIKIYDTMSRDLREFVPIEDGKIKMYVCGPTVYNYIHVGNARST
                     VAFDTIRRYFEYRGYKVAYISNFTDVDDKIINRAREEGITPQEVADKYIAAFREDVTA
                     LGVKPATRHPRVVEFMADIIRFVEDLIEKGFAYESQGDVYFRVEKSHNYAKLANKTLE
                     DLDLGASGRTDEETARKENPVDFALWKSSKPGEISWDSPWGPGRPGWHIECSVMSTEI
                     LGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKAFANYWMHNGFVNIDNVKMSKSLGNF
                     ITVHDALKTLDGQVLRFFFATQHYRKPINFTEKAVRDAETNLKYLKNTYEQPFTGNVD
                     AQELQNFKDKFVAAMDEDFNAANGITVVFEMAKWINSGNYDASVKQALADMLEIFGIV
                     FVEEVLDAEIEDLIQKRQEARANRDFETADQIRDQLAAQGIKLLDTKDGVRWTRD"
     gene            complement(34293..35177)
                     /locus_tag="AC0DU4_000471"
     CDS             complement(34293..35177)
                     /locus_tag="AC0DU4_000471"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236481.1"
                     /translation="MIQARNKLSQEELSEAKKVINCCQNYDGTYRDPYLSNMLNFDPN
                     MPAFFLYYEKGELVGLLTVYADDQDVEVTILVHPGHRRQGIARALFTSFERETASFPI
                     RSVTFQTERIFLENHPDFASNWGLIEDEETETWLGKDRRPYPLANVSHLEILLADSSY
                     QDQISQLKFQAFSEEHESREVVDRYVAEALKDPESRLYILLKAGQVIGTCTVDLSTNT
                     NYLYGLAILEPERGKGYGSYLAKSLVNQLIEQNDKEFQIAVEDSNVGAKRLYEKIGFV
                     KQTQVVYLNEKGARDSEV"
     gene            complement(35189..35806)
                     /gene="cysE"
                     /locus_tag="AC0DU4_000472"
     CDS             complement(35189..35806)
                     /gene="cysE"
                     /locus_tag="AC0DU4_000472"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000539958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0009001 - serine O-acetyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HIN4236482.1"
                     /translation="MGWWRETIDIVKENDPAARTTLEVLLTYPGVKALAAHRLSHFLW
                     KHGFKLLARMYSQFWRFWTQIEIHPGAQIDSGVFIDHGSGLVIGETAIVEKGVLLYHG
                     VTLGGTGKDCGKRHPTVRKGALISAHAQVIGPVEIGENAKVGAAAVVVADVPSDVTVV
                     GIPAKIVRLHGKKDEPVIHEVEEKREYYVNKLEQAKDASHRSSGL"
     gene            complement(35822..38035)
                     /gene="pnp"
                     /locus_tag="AC0DU4_000473"
     CDS             complement(35822..38035)
                     /gene="pnp"
                     /locus_tag="AC0DU4_000473"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001854499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004654 - polyribonucleotide
                     nucleotidyltransferase activity [Evidence IEA];
                     GO_process: GO:0006402 - mRNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HIN4236483.1"
                     /translation="MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAV
                     MSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFA
                     EGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQII
                     INPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQE
                     EIVAAVGKEKAEVELLHVDAELQAEIIAAYNSDLQKAVQVEEKLAREAATQAVKDQVT
                     AVYEEKYANHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAVV
                     DFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGE
                     TGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGT
                     LALMAGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITAL
                     QMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRLELAPTAPKIDTIKIDVD
                     KIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKV
                     DEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNRVEDLVEIGDEVDVKVIKI
                     DEKGRIDASMKALLPRPPKPEHDEKGEKSERPHRPRHHKDYKPKKEFTETPKDSE"
     gene            38140..38412
                     /locus_tag="AC0DU4_000474"
     CDS             38140..38412
                     /locus_tag="AC0DU4_000474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine methyltransferase"
                     /protein_id="HIN4236484.1"
                     /translation="MKTRQFIFFTQLFGRVQLLKMLSRQATQRKIGNRTTERLLLGRF
                     IFFHRVVGVFSFQDTSLERFNIKVSKPFTLIAIGRLAKCFTNSFVK"
     gene            complement(38594..39460)
                     /gene="metF"
                     /locus_tag="AC0DU4_000475"
     CDS             complement(38594..39460)
                     /gene="metF"
                     /locus_tag="AC0DU4_000475"
                     /EC_number="1.5.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000089969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA];
                     GO_process: GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="HIN4236485.1"
                     /translation="MSRQTPSLSFEVFPPNPAVGNDNIISALQDMQELAPHFISVTAS
                     NNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALR
                     GDIIPDVEPQKDFRYATDLIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKV
                     DAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIH
                     LPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQ
                     ATHALFNHQSLG"
     gene            complement(39524..41773)
                     /gene="metE"
                     /locus_tag="AC0DU4_000476"
     CDS             complement(39524..41773)
                     /gene="metE"
                     /locus_tag="AC0DU4_000476"
                     /EC_number="2.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003871 -
                     5-methyltetrahydropteroyltriglutamate-homocysteine
                     S-methyltransferase activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine S-methyltransferase"
                     /protein_id="HIN4236486.1"
                     /translation="MSTTIIGFPRLGEFRELKFTTEKYFRKEISEEELLAAAKDLRAK
                     HWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQG
                     EKGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVG
                     PFTFLQLSDFEEGVKADDFVDSLVAAYQEVFAKLAELGATRIQLDEAALVKDLTAEEK
                     ALFLNLYNKLLADKKGLEVLLQTYFGDVRDVYADLVNLPVDAIGLDFVEGKKTLELVK
                     GGFPADKTLYVGIVNGKNIWRNNYEKSLAVLEQIPAENIVLTSSCSLLHVPFTTANEE
                     FEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAG
                     LTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKE
                     YDAFLAETIDEWIKWQEDIDFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGM
                     RGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTILNWSFPREDISIKD
                     STLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVH
                     STVAPDTQIHTHMCYSEFTDIIPAIDNMDADVISFEANRSNLEILDELKAKNFQTEVG
                     PGVYDIHSPRVPNEGEIDNTIEAILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVE
                     AAKAAREKL"
     gene            complement(42034..42300)
                     /locus_tag="AC0DU4_000477"
     CDS             complement(42034..42300)
                     /locus_tag="AC0DU4_000477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236487.1"
                     /translation="MEGCPSELFSKEEILESDMRVAIMSELIEARYEQGISQKKLEEV
                     SGISQPVIARMETGKTSPQLDTVLKVLASLGKTLAIVPLEQGKS"
     gene            complement(42426..42841)
                     /locus_tag="AC0DU4_000478"
                     /pseudo
     CDS             complement(42426..42841)
                     /locus_tag="AC0DU4_000478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
     gene            42997..43998
                     /locus_tag="AC0DU4_000479"
     CDS             42997..43998
                     /locus_tag="AC0DU4_000479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000597989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HIN4236488.1"
                     /translation="MIKTFLSALSVILFSIPIITYSFFPSSNLNIWLSTQPILAQIYA
                     FPLATATMAAILSFLFFFLSFYKKNKQIRFYSGILLLLSLILLLFGTDKTLSSASNKT
                     KTLKLVTWNVANQIEAQHIERIFSHFDADMAIFPELATNIRGEQENQRIKLLFHQVGL
                     SMANYDIFTSPPTNSGIAPVTVIVKKSYGFYTEAKTFHTTRFGTIVLHSRKQNIPDII
                     ALHTAPPLPGLMEIWKQDLNIIHNQLASKYPKAIIAGDFNATMRHGALAKISSHRDAL
                     NALPPFERGTWNSQSPKLFNATIDHILLPKNHYYVKDLDIVSFQNSDHRCIFTEITF"
     gene            complement(44066..46471)
                     /gene="pheT"
                     /locus_tag="AC0DU4_000480"
     CDS             complement(44066..46471)
                     /gene="pheT"
                     /locus_tag="AC0DU4_000480"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HIN4236489.1"
                     /translation="MLVSYKWLKELVDIDVPSQELAEKMSTTGIEVEGVESPAAGLSK
                     IVVGEVLSCEDVPETHLHVCQINVGEEEERQIVCGAPNVRAGIKVMVALPGARIADNY
                     KIKKGKIRGLESLGMICSLGELGISDSVVPKEFADGIQILPEDAVPGEEVFSYLDLDD
                     EIIELSITPNRADALSMCGVAHEVAAIYDKAVNFKKFTLTETNEAAADALSVSIETDK
                     APYYAARILDNVTIAPSPQWLQNLLMNEGIRPINNVVDVTNYILLYFGQPMHAFDLDT
                     FEGTDIRVREARDGEKLVTLDGEERDLAETDLVITVADKPVALAGVMGGQATEISEKS
                     SRVILEAAVFNGKSIRKTSGRLNLRSESSSRFEKGINVATVNEALDAAASMIAELAGA
                     TVRKGIVSAGELDTSDVEVSSTLADVNRVLGTELSYADVEDVFRRLGFGLSGNADSFT
                     VSVPRRRWDITIEADLFEEIARIYGYDRLPTSLPKDDGTAGELTVIQKLRRQVRTIAE
                     GAGLTEIITYALTTPEKAVEFTAQPSNLTELMWPMTVDRSVLRQNMISGILDTVAYNV
                     ARKNKNLALYEIGKVFEQTGNPKEELPNEINSFAFALTGLVAEKDFQTAAVPVDFFYA
                     KGILEALFTRLGLQVTYTATSEIVSLHPGRTAVISLGDQVLGFLGQVHPVTAKAYDIP
                     ETYVAELNLSAIEGALQPAVPFVEITKFPAVSRDVALLLKAEVTHQEVVDAIQAAGVK
                     RLTDIKLFDVFSGEKLGLGMKSMAYSLTFQNPEDSLTDEEVARYMEKIQASLEEKVNA
                     EVR"
     gene            complement(46548..47057)
                     /locus_tag="AC0DU4_000481"
     CDS             complement(46548..47057)
                     /locus_tag="AC0DU4_000481"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236490.1"
                     /translation="MIRKVEMADVEVLAKIAKQTFRETFAYDNTEEQLQEYFEEAYSL
                     KTLSTELGNPDSETYFIMHEEEIAGFLKVNWGSAQTERELEDAFEIQRLYVLQKFQGF
                     GLGKQLFEFALELATKNSFSWAWLGVWEHNTKAQAFYNRYGFEKFSQHHFMVGQKVDT
                     DWLLRKKLR"
     gene            complement(47057..>47788)
                     /gene="pheS"
                     /locus_tag="AC0DU4_000482"
     CDS             complement(47057..>47788)
                     /gene="pheS"
                     /locus_tag="AC0DU4_000482"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HIN4236491.1"
                     /translation="PVATGHRHVLTQTSEEIEDIFIGMGYQVVDGFEVEQDYYNFERM
                     NLPKDHPARDMQDTFYITEEILLRTHTSPVQARAMDAHDFSKGPLKMISPGRVFRRDT
                     DDATHSHQFHQIEGLVVGKNISMADLQGTLQLIVQKMFGEERQIRLRPSYFPFTEPSV
                     EVDVSCFKCGGEGCNVCKKTGWIEIMGAGMVHPRVLEMSGIDATVYSGFAFGLGQERV
                     AMLRYGINDIRGFYQGDVRFSEQFK"
BASE COUNT        13553 a        10862 c         9037 g        14336 t
ORIGIN      
        1 ggctccgacg gagtaagttg ctttcgtgaa caccaaaatc agccgcaatt tcttcataag
       61 tgcggtattc tcgcacatat tgaagagtgg ccataagaag gtcttctagg cttaatttag
      121 gttttcgtcc accttttgcg tgtttaagtt gataagctgt ttttaataca gctagcatct
      181 cttcaaaagt cgtgcgctga acaccaacaa gacgcttaaa tcgtgcatca gttagttgtt
      241 tacttgcttc atcattcata gaactactat accatatttt gtttcgcagg aagtctaatc
      301 tcatccggtt ttgcttggcg ggtttctgcg gtcatttttt caaaagggac ccaccagact
      361 ggcccacagt ccttgagacc gtggccattc atatcacctc ttcgtctagg gaaaaggtgc
      421 cagtggagat gggcatcgcc atttcctaga agttcaatat tcattttctc agcagtaaag
      481 cccttggcaa ctgcctcttg gactaaactc atttcttcta gaaaatggag tcttgtgtcc
      541 ttttctaaaa tggtgcaatt ccgtgacatg ttccttggct agaaagagac tatagcttgc
      601 aaaatactga tggtctccaa tcacaagata gcctgttccc aactctttga caaagtaggg
      661 attttctccc ttcttgatga gctcaattct ctggcaaata aggcacatat caatctacta
      721 aattgcttct aagataggca tcgaccattc gttctgttgc gaccaccgag tcaatatgag
      781 tgcgctcata agaatgacta gactcgatac ccgcaccaag aagggcatgc ttgacctctg
      841 cccctgcaga catagccgct gaagcatccg aaccataaaa tggatagatg tccagcttaa
      901 aaggaatatc ttgctcttta gccaaggcaa ccaagtgttg acggaagtca tagtgataag
      961 gacctgaagc atccttgaca cagatagata ctgtgtactc atctgtctgc tggtcatctc
     1021 ccattgcccc catatcgaca gctagatatt ccaccacttg agttggaata ttggaattag
     1081 caccgtggcc cacctcttcg aaaactgaaa aagcaaaatg agttgttact ggcaattcaa
     1141 ttccctcttc cttataaaca cgaagaagat tgagcaaaat tgctgcgctg accttgtcat
     1201 ccaagtggcg agacttgata aaaccagtct ctgtcacaac agttcgcgga tcgaaactaa
     1261 taaagtctcc aacctcaata cccaaggcgc gcgtttcttt ttcattggtt acttttgcgt
     1321 ccaaacgcac ttccatattg tcctgcgtac gttctgcagt tcctgcatcc ttgtagacat
     1381 gacaagaagt ctggtggatg aggatggtcc cagataccgt ttgacctgtg ctagccacat
     1441 gaacggtaca gttttctcct tcaatcatgt tccaaggaaa accaccaata cgatccaatt
     1501 tgagacggcc atctggtttg actgcacgaa caatagcacc cagcgtatcc acatgggctg
     1561 tcacatagcg ttgttgttca tcattttgac ctttaatggt cacattgaca ccacccttag
     1621 ctgtacgaac aggctggtaa ccaagtttct ctaaagtatg gactagatag tctgagatct
     1681 cacgagtaaa gcccgttgga gatgcaatag cggttagttc tttgatatag tttatagtct
     1741 gattcatttc ttcacctctt tcgctaccta ttataacaca tttatcatcg gataaaaaaa
     1801 gaaaatcact cctgtagact tggctacaaa agtgatttaa gtgattattc catttcaaaa
     1861 acatcgcttt cttgcttgtt tggtagaacc aatgagagca agattccaac aatggctggc
     1921 accaaccatg ggagagatgc cttggcaaaa ggaagaacgc taacaagatt tgcaagaaac
     1981 tcaaccttaa acgagcttcc tagtacgctt gcaatggcaa taactgtaac cacagcaatt
     2041 gtcaactgca tacctggttt tgaaagggca acaaatttgt tgacaatgac aatcataacg
     2101 atagcaatcg tgattgggta caagataacc agtactggaa ttgagtactt gataatcgca
     2161 tcaagaccca aattggcaat agcaaatcca atcaaggtaa aggctgtcgc ataaaccttg
     2221 tagctgattt gtgggaagcg ctcattaaag aactcagctg ttgacacaat caaaccaaca
     2281 gtcgttgtga agcaggttac ggtaaccata gctgcaagga agagttgagc tgttgagcca
     2341 aagatttctt gagtggcttg tgacaagatg taaacacctg gtgttccacc cttcatcgct
     2401 tcagctggta ctgggaaatg atttccaaga aaacctaaac cgatgtaaag agcgctgaag
     2461 gcaagggcaa caacgatacc aacaacccaa atagttgaaa tgtattcttt cttacttgaa
     2521 aatccaagtt gtttcaaggt ttgaactgcg attacgctaa aggccactga ggcaagggcg
     2581 tccaaggtat tataaccttc taggaaacct gtaccaaagg cagaagcttg ataagcagct
     2641 gaagcagctt gaggacttgt tccaccatat ttgatagctc ccagaacgac caagataaca
     2701 atcaaaattg caaagactgg cgttaaaata cgtccaatgc ggtctaagat ttttgatgga
     2761 ttaagcgaaa tcaaataggc taccgcaaaa tacagaaccg taaatacaat caagccaagt
     2821 cctttatttg catccgacaa aagggggcta atccctactt cgtaagctgt tgtagcagta
     2881 cgtggggtag caaagaatgg accgattgac aagtaaagaa ctgagaggta aagagtcgca
     2941 aaccaaggcg ctatcttcgt tgaaatctcg tagatatatc ctttaggatt tagcgttcca
     3001 ataataaggg tcaagacggc gataccaacg cctgaaaaga caaaacctgc gatggcagga
     3061 agaaaatgtt ctccagatag agcacctaga gaaggcggaa aaatcaagtt ccccgcacca
     3121 aaaaatattc caaacaggag caaacctgtt agggtacctt ttttagccat aaaaatctcc
     3181 ttcatattta taaaatactg acctagtata ccacgattag gagtctgaaa aaagcatcac
     3241 gaggcaaata ttaaatgttt tcaattttct taaaaataag aattatctaa aaacaaaact
     3301 ctcctaccca gtccacacca agtaggagaa atgcaaaatt ttaaagttct tcaaaggcta
     3361 acatgccacc ctggacattg ataacattat aaccttgttc taacaggaat tggcaagcac
     3421 gcgccgatct cattccagat ttgcaaataa tataatgcaa gcgatctttg tccaattaat
     3481 cataactatc agccaattga ctaagcggta ggttgtgggt accttctaaa tgaagagctg
     3541 caagctcatc cacttctctc acatccacta gagaaagctg gtcgttttgg taaagctgat
     3601 aaaatgcgtc aaaggctatt tctttcattc tttttcttct aatactcttc gaaaatctct
     3661 tcaaaccacg tcagcgtcgc cttaccgtgc gtatgttacc gacttcgtca gttttatctg
     3721 caacttcaaa gctgtacttt gagcagccta cgactagctt cctagtttgc tctttgattt
     3781 tcattgacta taaaatggtt ttaattcttt ttttcaaatc tggcactact tctgcctcaa
     3841 accaaggatt tttggacatc cagatttgat ttcgtggtga tgggtgaact agcggaaaat
     3901 aggctggcag atagtcttta tagtgtttca ccctctccgt taccttccca ctgattttct
     3961 cctgtaaata gtaggcttgg gcatattgcc caatcaagag ggttaactga atatcaggca
     4021 attcctgtaa gagctgcgga tgccattttt ctgcaaaatc tgtacgaggc ggaagatcac
     4081 ccgacttgcc atgtcctgga aagtagaaat ccataggcaa aacagcaaaa taacctgaat
     4141 tgtaaaaggt atcttcatcc acacctagcc agtcccgcaa gcggtcacca cttttatctt
     4201 tccagtaaag gtctgcttct tgagttttaa gtcccggagc ctgaccgatg atattgatgc
     4261 gagcagtttt tggcgctaca aagagaggct caatgccacg ctctgtatag ctggcattct
     4321 gcgaatccgc catgatagcc tgtttgattc tttcgatttg agacatctac tttccctcca
     4381 aaaagaagtc caagcataag atctcagact tctatcgttt tatttgatca attcgtaaat
     4441 agcttcggca taaattgctg ctgctcggaa gagatcgtcc aaggcaataa attcattggc
     4501 ttggtgcata gtatcaattg agtctgggaa catagcacca taggcaactc cgcgctctaa
     4561 caagcgacca aaggttccac caccgatgac ttgttcatga ccttgtaggc ctgtttgttt
     4621 ttcatagaca ttcaacaagg tttgcacaag tggatcttcc attggcacat agtgaggggt
     4681 atgaccatgt tctgatagac tgacagaagc aactggcaag ttttctagga ttgacttgat
     4741 ttgttctgga cttgttcctt ttggatagcg gatgttgagg gcaatggtat tatcagcaca
     4801 tgtttcatcg aagcggaaga cgcctgcatt catagaaagg gcacccatct tttcatccac
     4861 atgagcaatc ttgagacttt caccctcatg gtcgttcaag agaattttac cagtgatgtc
     4921 aaggtattct ttggctggac cagcaaagtc aaactggcta aggaagaggg ctaggtaagt
     4981 cgcaccattg acacctgaag caggcatagc accgtgggct gatttaccaa tgatcgtcac
     5041 cttgtatttg ccagcttctt cttggagttc tcctctaagt ttgtgttctg caacaaaggc
     5101 atctagttta gcttgcaagt cagccaaatc acctgaaacg actgctgttg ctgattctgg
     5161 taccatattt tcacgtaaac cacctgtaaa gctgtgaaga cgggcagcac ctgtattttc
     5221 tcctgcaaag tggaggtatt ccgtgatatt tcctttttca ccattgatga tagggaattc
     5281 agcgtctgga gagaaaccga aatctggttt ggcaagtcct acgtgctcaa agtagtagtc
     5341 catatctgcc cagcctgatt cttcgtctgt tccaacgatg aagcgaactt tcttagaagt
     5401 tggaagaccc aattctttga tgattttcaa accatagtaa caagctgttg taggaccctt
     5461 atcgtccgaa gccccgcgcg cataaaggcg accatctttg atagttggtg tgtaaggatc
     5521 tgtatcccaa ccgctaccag ctggaaccac gtccatatgg gcaaagattc cgagaacttc
     5581 ttctccatca ccaaactcaa aatgtcctgc atagttatca acatttttag ttggataacc
     5641 atcacggtct gcgatttcaa ggaatttttc caaggctttt actggaccag gtccaaatgg
     5701 atgttgggca tcagccttgc tatcatcacg ttctgagttg atttccaaaa ggctaaacaa
     5761 gtcagccaag aggtcttctt tgcgtttttc tacttctgct gtaaaatcaa ttgctatcat
     5821 tttttcttct tcctatcttt tttcgatgat ttcatctact ggcaagcggt agcttggttc
     5881 caatttgtcg tctgtgtaac ccactgtgat caagagttct gggcggaaac ggtcttcgat
     5941 ttccaaaact tcattaactt ttgatttgtc aaaaccaagg ataatattgg aaccaattcc
     6001 ttggtctgta agagcgagaa ccaagttcat agcaaccaaa cctgcattga gtgctaggta
     6061 gtcgctgact tgttgttcat tgtagcgtgc aaattcagct ggcaaatttt tcatgaagta
     6121 ttgaagttgt tcttctgaga aattgttagc accaccaact cgggcaatct tacgagcgcg
     6181 tttggcaagg tctgtatctg taaatagggc aatggttaca ggtgctgatg atacctgttc
     6241 aaaattggaa ccataagcta actttgccag ttcagcattt ttctcacata ccaccacaaa
     6301 tttccaaggc tggctgttgt gggcgcttgg cgccaaggtt gcaatttcga tagccgtacg
     6361 cacatctttt ggatcaacag gcttatcagt gaaatgcttg gtcgcatgac gttttttatt
     6421 taattcaaga aatttcataa tcgatttcct tttctaattc tactgcttcc attctaccat
     6481 aatttgaaag agcttgcagg gatttttcat gattaagttt ttctatcaca gacataaaag
     6541 atatatattg gtttatcagg aaagtttctg ataaactagc aagtacttta catttgaatg
     6601 gagacagtat gaaaaaattt agcctattac tagctatcct accatttttg gttgcctgtg
     6661 ggaatcaagc tacacccaaa gagtccagct ctcaaaagac aatcgtcctt gctacagctg
     6721 gcgatgtgcc accatttgac tacgaagaca agggcaatct gacaggcttc gatatcgaag
     6781 tcctaaaagc agtggatgaa aaactcagcg attacgagat tcaattccaa agaactgctt
     6841 gggagagcat cttcccagga cttgattctg gtcactatca agcagcagct aataatttga
     6901 gttacacaaa agagcgcgct gaaaaatacc tctactcgct tccaatttcc aacaatcccc
     6961 tcgtccttgt cagcaacaag aaaaatcctt tgacttatct tgaccagatc gctggtaaaa
     7021 caacacaaga ggataccgga acttctaacg ctcaattcat caataactgg aatcagaaac
     7081 acactgataa tcccgctaca attgattttt ctggtgagga tattggtaaa cgaatcctag
     7141 accttgctaa cggagagttt gatttcctag tttttgacaa ggtatccgtt caaaagatta
     7201 tcaaggaccg tggtttagac ctctcagtcg ttgatttacc ttctacagat agccccagca
     7261 actatatcgt tttctcaagt gaccaaaaag agtttaaaga gaaatttgat aaagcgctca
     7321 aagaactcta gcaagacgga acccttgaaa aactcagcaa tacctatcta ggtggttctt
     7381 acctcccaga tcaatctcag ttacaataac actcttcgaa aatctcttca aaccacgtca
     7441 gctttatctg caacctcaaa gctgtgcttt gagcaaccta cggctagctt cctagtttgc
     7501 tctttgattt tcattgagta taagatatat aaaagcgatt ggactaccaa tcgtttttag
     7561 tttgcattgg ttattttagg aaactcttac aaaaaatcaa aaaaattctt cacatcctct
     7621 acatacctat gcttttctat taagcttgct aatagtttca gattgtgcct ctgatagtta
     7681 tcttcacgac gtagttcttc atacatttcg ataaagggaa gccccttgga tttggccaat
     7741 tctaactcag cctcgtaatc ataagcaact ttacgaaatt ggatattgag taattcccca
     7801 tcttcaacct ctatcacggc atactgggca cggtgatttt ttaacgcctc ccaattaaaa
     7861 tagggcatgc caatcgaccc tggattgatg atttgttgcc ctttactgcc gtagcgaagc
     7921 aactgcttgt gaacatgacc ataaactgcc acgtccgttt ccgcatctag cagttggtca
     7981 aatttctctg tatcattctc aactagcaag tcaccaccat agtttttgtc aggtaaatta
     8041 tgagagatag aaaagcgcaa tccgtcaatt tctttctttt ccagcaaagg caagcttcgt
     8101 agccagacaa tcgttgcagg atccattcgc tccatcaaaa actgggtcat gcgcattgac
     8161 tggatttctt tcggatattc caaaccatat tcgccatcca agacctcaag gacacgatca
     8221 tcccaattgc ctcgaacact tgctgtgata ggaaggtcct ttagcagggc gactaagtca
     8281 tttgcgcctg gaccaggaag aaaaatatct ccctgaagcc aatattcact ggccccttga
     8341 tttttagcat ctgcaatcac tgcttctagc gccgtcgcat tgccatgaac atctgataaa
     8401 attgcgattt tatggttcat tgtggtttcc ttccgtttgg taatctactc tttcttctgc
     8461 tacttgaggc aaggcttctc cctgcgggtt caactttctt tgcacagcct ctgcaacgac
     8521 tctaggtacc ccaacttcga caatctcatc cacactggct tccttgattt tggtcaaaga
     8581 cttgaaatgc ttcataagat tctgcttgcg tttaggtccc agaccgtcaa tcccatccaa
     8641 ttgagatgag aaagaatttt tggagcgcag ttggcggtgg aaagtgatag caaagcggtg
     8701 cacctcatct tggatgcgtt ggaggaggaa aaattcctga gaattgcgag acaagtccac
     8761 cacctcaagc ggatctccaa agagcaattc atgggtttgg tgcttatcat tcttttgcag
     8821 cccagcaatt ggaatatcca agcccagttc ctcttggatg acttgcttag caatattgac
     8881 ttgaccttgc cccccatcaa tcacaatcaa atctggagga gtcaaagcct cacgctgtac
     8941 tcgaccatag cgtctgcgaa tgacttctct catactagca tagtcgtccg gcccaacaac
     9001 ggtttttatc ttgtacttac ggtaatcttt tttacttggc ctgccgttaa caaagaccac
     9061 catggctgaa acaggactgg tccccatgat gttggagtta tcgaaggact cgatgcgaac
     9121 tggagtcgga atttggagca aacgtcctag attttcaata gctccttggg tcttttcgac
     9181 tgatttttct agcagattga acttctgctc tagactaaca cgagcatttt ttatggctag
     9241 attgaccagc tgttttttct ctccacgttg gggtttgaga atcttggtat ccaccaaagc
     9301 cttgacagct tcttcgtcaa tatcctgcgg aatcagtacc tcattgggaa ctaggtgaga
     9361 tttttcttga tagaattgtc ccacataggt caagaaatcc tcatctggat cattgaagta
     9421 ggggaagaga ttgacatcgc gctcgatgag cttgccctga cgaacaaaga aaacctgcac
     9481 acacatccag cccttatcca catagtagcc aaagacatcg cgattttgga gatccttagc
     9541 catgacccgt tgcttggttc gaagtgttcc aatggcctga atcaggtcac ggtattccgc
     9601 tgcccgttca aactccatac tttgtgctgt tactgccatt ttactcttga gatcatcgat
     9661 gattttgtca tcctgacctt tcagaaaatc agacacctcc tgggccatgg acttgaaata
     9721 ggcctcgtca ttcttacaga tggtgtgggc catacattgg ccgatatggt agtaaaaaca
     9781 gaccttagag ggcgggttgg tacattttcg aaaagggaaa atcctatcta gaagtcgctt
     9841 gatttcattg gctgccccca catctggata agggccaaaa taaagaccac cgtccttttt
     9901 gacctgacga gtaatgataa gccgtggata gtgctcattg gtgattttga taaaaggata
     9961 agacttgtca tccttgagca tgatattgta cttgggctta ttttccttga tcaggttgat
    10021 ttccagcaga agcgcctcaa tattagactc cgtaacaata aattcaaaat ccacaatttc
    10081 agacaccaag gcctctgttt tggtatcatg acttccacgg aaataagacc tcacgcgatt
    10141 acgcagattt ttagcctttc ctacatagat aatggtgccg tttttatcct tgtaaatgta
    10201 gcaaccaggg ctggtcggca agagctctag ttttggttta atcaagttgt tcatagttcc
    10261 attatagcaa aaaagtaggg aaagatagta ccctactcat tagtctcata tatttttcgg
    10321 aggtttgcaa catcctcttc ctggatacca taaaaggaac ctgctggttg catgacagac
    10381 ttctcatctg tatggtccaa gccaatcgca tgacctaact catgttctgc cgtatggaca
    10441 aggcgttcat aggaatagcc atagtatgga ttggacaaat aataatgatt caaccgcacc
    10501 gttacggaca agaattgccc tgttaagaga ttagtttgac tttccgcctc tcctgccaca
    10561 ggagtgcctc cgtcgttcat ctccgtagcc gtaatatccg ccttactaga ctcagtcacg
    10621 agttcaaagt taaaagcacc agtttgattc cagttctgga ttgcttctaa ataagcctct
    10681 tgaaagcgtg aatccatctg cggatccagg taaatacgag cagaggcctg tggccacctt
    10741 ccttcagaat gctggtgact atctgtctgg cttaacttag gcagttgccc tgttttctcc
    10801 cattggtcaa tactttgttg accaattttt actgaccgtt ctgcttgctt tagcgctcct
    10861 tgaaaatccc cgttcagata ccagagaagt ccgaaagcaa gcacacataa gagcacaact
    10921 atccaaacca gacgccaaaa caaacgccac acaaaagaaa agaaagcccc tatcaaacga
    10981 aaaagccagc gcatgtctct ccacctttct agcaaataaa aattatttta ctaaaagaag
    11041 ctaaaagaaa tctaaatact gactttttca tcttaacgtc ctactatttt tttgagtaac
    11101 tggatagctt tgtattttaa aggagatgga tggtaacgga aagtacctgc tttgcgtaca
    11161 atatagccat taaaattctg tttaaaacgc aaaacaccat cacttccatc aaaaatccct
    11221 tgaatgccta ggaagttgta tttaggtatt ccacgtttta tgctttccaa cataacatat
    11281 ttttgaagca gtgcaggggc atagaactta ttaaactcag tgtaggaacc actaaagaga
    11341 taagtcgttt cctgaggcat ataaacaaat aaactcccag ctaaaacaat atcttcttct
    11401 ccatattttt caatcaagtc tcgcgcttct gcttttcgaa cttcaaacgt ttcaaattga
    11461 ctagaatatt ctctcagttg attttgtttt ttctcagaat gaggattttt actcaaatca
    11521 agtcgcaact tgtccaagtt ttcttctagt ttattttgtt caccttgcaa tttgctcata
    11581 tagtccgaaa aatttaagct tgctatgaga aactccgctt gttctccaaa agtatcataa
    11641 aaatgctcat aatattctaa acttttatca ctatattctc tacgttcaga ggtttctttt
    11701 gttatattct taaaaatcga tagttcttca cgttttaact ttttcaatcg aatgccaaag
    11761 gtttcagcct ttttcaccaa gggtttaccc tttttgctaa aacttttaag caaactcttt
    11821 tcagttaatt cagttaaatc tttatagtat aaccaatctg gttctccacc tgggtaacct
    11881 gttgttaagc catcaaattg ataacctaaa tcagtcaaac cttgaataat actttttttc
    11941 tcagcatcta ttggattacc ttggctatca aaagtttgat aagtttcata aggttttaca
    12001 agcaactcta atacaccatt ttgcttggca tattctttta actctgcata aaaaactgga
    12061 agagcatctt gttgggtata aatcggcccc gaattgagtt ccatatgcag accacccagc
    12121 atgggcaagc tataaaccag agctgcaact tgaatttctc cttcttgttt caaagcaaga
    12181 taaacaattc gagcccctct tttttctagc aaatccccca tctggacaga ttgcataaag
    12241 gaacgagaag aaacctgatc agaataagtc tgaaactctt ctttcgtgag tgttgttagt
    12301 gccatatact tactttctat gtttttttct taatgtttta cggaaatcaa gagcaagtct
    12361 taacagagga tagagaggat gagtgggcat tgtaaattca cccaagtatt cttcaatcgt
    12421 tggattaaat ttttccttaa aatgataaag tccaccattg agagagtttt caacaccacc
    12481 taaattttgc cagaccatac ctcgctcaaa ggcatagcga gccgtttcat accatgttaa
    12541 aattggtgca ttgtaacgtt taaaatcatc atccatacca gcatatatat tgacagaggt
    12601 agtaccaaat tccaaactca aagtagccgc taaaggaact ctcgcttgac ctacatctat
    12661 atattcctgc aagaaggtca attcctctaa caaacgttct ttttccttct tctgcgcttc
    12721 tacttttgaa gttcgagtcg actcagtaaa ggtctcttcc aaggctctat ttttcgctaa
    12781 ctgttcttct aattcttgcg aacgtttaga aacatccaag gtggccaagg tgatataggc
    12841 cttgtcctta aaattatcta acaatttttt ataataggct tcattcctca aatgaatctc
    12901 ttttcgcttc tcagtttttt tcatcaactc cgaaaatgaa tctaatagtt ccagtccacc
    12961 atattgaatc tcaagccctt tgtttcgtgc tgttcgaata gcctgttttg ttgacttgga
    13021 aagtttatct tcttcaaaat tttccttgta tattttcgcc tgaatacgag gttgaatggt
    13081 gtctcccatt tcctccgttt ttcctgacca ccttactccc atttgttgca aactatcaat
    13141 aatagccaga ttttcaggaa attctgtctt ttcctgattg attaaacttt gagataggca
    13201 aatacttggg tcaaaagtca caaaaaccgc tctcttactg cgagcatagg acttaataga
    13261 ctgaatggca aaattcaaga gttctttatc cccataatcc aatataggtc ctcttgggat
    13321 gtaaaacatt ttatagccta gcggaagagt tctaatcaaa atactagctg tcgccagtaa
    13381 tttttcttcc ctgtaaacac caaacttctc atgttgccaa ttagacttaa cttcctccca
    13441 agcactactt tgtaatacat tggctaattc atgttctttg acaaactgat catattctaa
    13501 tgtgggaatg ccaatttgat aacggtacat ttcctactct ctttcctcca gtattttatt
    13561 actattctac tactttcgtt tgaaaagtct agtgaaaaca tattttattt tagttctact
    13621 ccccctatgc tgaagttcaa actaagtcag tctctcttct aatttgaaat caattggtag
    13681 ggttgttaaa aaaacttcca attgtttttc ccagtagtac cactcgtgag ttccagcact
    13741 atggctatag gtcacatcaa aacctagttt tttgagattt ttcactgcga gattattggc
    13801 ttcgtacaag aaatcctgtt cgccacacca cgcccaaagt ttggtctttt tatccgattt
    13861 tttagccaga ctttcaagag aatagggact agttgtccag tctctaatct ctccaaaaac
    13921 acctctccag taggctggac ttcccagatt ttgactttca ggagaaaagt tttgaaagct
    13981 gagggcacct gaaaaactag ctgcatgaga aaaacgattt gtcgtaagag ccagtttgaa
    14041 gcagccgtag cctcccatag aaagaccagc gataaaggtc ttttcacgct tgctagtcat
    14101 attagggaag aagcgtttca gaacctgcgg caattcctct gctagagccg tgtagtagtc
    14161 aaaaccatac tgggtatcgg tgtaccaacc attgctggta ttgggcataa caacgatgag
    14221 attagttcct cgaagcaagc gttctacatt ggtccgctta agccaactat tatgatttcc
    14281 agacatcccg tgcaaaaggt acaagacggg aatatcttca cactctggtt cttccactcg
    14341 attggcatca gggtagagga cattcacccc ccactccata tccaatactt gtgagtaata
    14401 ctcgattttc attactgcca tgattttctc cttctatttt tctataagaa aaagccgaaa
    14461 ctcgactttc tctctgttta tttcaacgat tattttgctt ccatgactac tggtaaaata
    14521 gctggacgac gcttggtttg gtcaaagaga tacttggtca aattatctcg aaccttccct
    14581 ttaagatctg cccagtcaaa gtcatctcct tgaagataat cttctaccgt ttggttaatc
    14641 aattctgaac tttcacggag aatatcgcga ctcttcttga gataaacaaa tccacgcgtg
    14701 tgaacacgag ccctagccac aattttcttc tcacgacggt tgactgtaat agccacgatg
    14761 aaaattccat cctctgacaa gaccttacgg tcacgaagaa caacatttcc aacatcacca
    14821 atggcattcc catcaatcaa gatatctcct gctgaaaccg atccagctgg aacaaagtct
    14881 ccattctcgt aagccatggt cgtccccttt ttaggaatga aaatgcgttc tggcaacatc
    14941 ccaactgcca tggcagcctt agcgtgagca tccaactcac gatactcccc ttggacaggg
    15001 aagaggtact taggttgcaa aagattgatc atcagctgca aatcacgcac atttccgtgc
    15061 cctgatacat gtaaactttg ggtaatcaat ttgacaaccc cacctgcctg ataaatcata
    15121 ttttccacac gcgcaacaaa ggcttcttta gcaatagacg gagccgtagc aatatagacc
    15181 aggtccccat ccttgatttc tacataacga tggcgaccaa tcgacatctt acgaagtcca
    15241 ttgataggtt cacccatacg acctgtctca agaataatca actcatggtc ttcaaagcga
    15301 gacatatctt taggcttaat caagagaatt tcgttggcta aagacaactt cttaagacga
    15361 atcgctgtgc ggacgatatt ttcaatatca aatcctgtca agacgatacg tcgacctgtt
    15421 ttatccgcag cgtcaaaaat ctgctgaata cgagaaagat tactggaaac agctgcaacg
    15481 atgatacgac cttcccagtc agcaatagtt tgggtaattt catccctaac ttcactttca
    15541 ctagccacct gaatattgct gtctgcattg gccgaatcac tgaggagagc caggacgccg
    15601 tcacgaccaa tctctgccaa acgagcaaaa tcagttgcat aagattcact agccgtttgg
    15661 tcaaatttga agtcacctgt ataaacgatg cttccttccg atgtcttcaa gacaattccc
    15721 agactctctg gaacggagta agtcgtaggg aagaaggaaa ccactgtccc accaaaatca
    15781 atctccgtat tctcatcaat gacatggaaa tcattaaatt tcttaacggc atcatttcct
    15841 ttgacaaaga gctttgccaa ctcaatggtc aactcagacc caaatacagg aactttagcc
    15901 tctgccaaga gataaggtag agcaccaatg gcatccgcat gcccgtgggt caagaaaacc
    15961 ccagcaatac ggtcgctatt ttcaaaaagg taatccatgt ttggaatcac cacatcgacc
    16021 cctaattgtt cattttcagg atattttaac cctacattca aaacaaaaat ggactctcca
    16081 atttcagcaa tgtacatatt ttttccattc tcacgcacac caccaagtgt tgttaaactg
    16141 atattactca tttttcctcc aaaatcttag tttatcttga ttatagggca attctaccct
    16201 cttattctaa aagttctgat actttcagcc gaatcttttc ctaccattat accatttttt
    16261 tgatgatttt caaaatgaag gtctgttttc aaaaaagagt tgatttccca actctttcct
    16321 aacttctact ctttttccat caaaaaatca taaatttctt gcaccgtacc cagcgccatc
    16381 atttcttggt ctttaacggt ttgtttgaga ttttggtaaa tttgactttc tcctatctcc
    16441 cgctttggcg cctctttatt gactgtcatc acaccatctt ttatcgtcac aaagcctagt
    16501 tcttcaaata cttgaatcat cttgaccagc aagatttgtt gaatattaag atatgcagcc
    16561 aaatctttca gcttgtagcg aatatcaaac tctgggaact ggtaaatagt cttgtacaat
    16621 ttagcaaact gatctctagt cccataacct gtcagataat aggtcttgtc aatatcattt
    16681 ttgaaataga cagcagagaa atgctgttcc tgaaaaatgg tcttcagctg agtaatatcc
    16741 tctggaatgt tttttacgac aacagcttca ctagccgcaa gatttggcag ttctccagga
    16801 aaatccaaga ctggaacacc ttctggcaag actgcatttt ttccacgaat gttaaaaagt
    16861 tgaacacctt ccactcgcgc atccaccatc atcaactgga gggcagtttg gccattccat
    16921 tggttgacag acaatttaac cgctaactct agattcttgg tttgagaaaa ctctgtcgcc
    16981 catctgcctt gaccaaaggc taccacttca aaactcgcct cacccttgga aattttcagc
    17041 tttagatggg cattacctgc ccccatagta cgagcacttt cgacctgaaa attcttgata
    17101 taaaaaatag gtttctgatt atccattcca aaaggagcta aacgttcaaa acttttgacc
    17161 gtttccaagc taagtgcctc caaatccaac tcttcatcta ggtttaactt attcttgcca
    17221 ccagcatctg cacctttttc acgaacataa tcttccaaaa cctgagataa atctgagagt
    17281 tgctcaactt ccagcgtcat acccgctgca cctgcatgac ctccaaaggc gatgaagagg
    17341 tctcgatggg gatccagagc ttcaaaaata tcgaccgctt ccacactacg agcactgccc
    17401 ttggcacgac cgtcttctat attaagaaca atgactgtct gtcccaattc ttccaataaa
    17461 cgaccagcca cgattcctag aaccccagga ttccagcctt ccttggccaa gacctgaacc
    17521 ttcttctcag gatccaccat ggtcttggct tcttcataga tagactgaac gatttccttg
    17581 cgctcttcgt ttttctggtg aatcataagg gcaatctcat gcgcttcctc atcatcaaat
    17641 ccagtcaaca aatcaatggc aggattggga tcatccaagc gacccaaggc attcaaacga
    17701 ggagcaatct ggaaaccaac cgtttcttct gttacttcgt tggcagcaat cccagccatg
    17761 tccagcattt cttgcagacc aatgcgctgg gtatgaccca acatttccag accatattga
    17821 actaagatac gattttcatc cgtcagactc accatatctg caatagttcc aatagcgacc
    17881 aaatcaagca attccacttg cacttcttct aacagggcac aagccaactt gaaagcaact
    17941 ccacaaccag ccaaatattt aaaaggataa tccgcatctg gatgttcagg atggacaata
    18001 gcataagcat ctggcagggt ttcaggcatg gaatgatggt ctgtcacaat gacatctact
    18061 cccatagact gagccaatgc aatagcctca tgaccagcaa ccccattgtc caccgtcaca
    18121 atcaaggaaa ttccttcttg ctcgataaag tatttataaa cactagcatt agggccatag
    18181 ccatcggtaa aacgatttgg caggtaaact cggcactcag caccaagttg ttccaaactt
    18241 tccttcacaa tagaagccga agtcatgcca tccgcatcat agtctccata aacgagaata
    18301 ttttcccctt cttcaatagc ctgacgaatc cgctccactg ccttgtccat atcatggagc
    18361 agataagcat catgtaagtc ctccaaggaa ggttctaaaa acttcttcag actttcttgg
    18421 tcctgaatcc ctctctcaaa caataaccga gccacctcag gacccagtcc agccttcttg
    18481 gctatctttg taaaatccgc atcttctacc tgcagggcaa actgccattc ataagtaggt
    18541 gttatcaaaa agacatccac tctttctaag aattctattg cttcattata acatgattta
    18601 gacgttttct ctatccagat tgctttttta taacatttta tagtatattg aaactagaat
    18661 agtacacctc tacttctaaa atattgttag aaatcgattt gactgtcccg atcgattttt
    18721 cctgttctta tttcactata gtgaattttt tcagatatga tttgacaaga acattctttt
    18781 attgcagaat cgtgttataa aatctaacat aaaggagttc tctcatggtt ttagtagaat
    18841 ttaaaaacgt cgaaaaatat tacggagact accacgcact ccgcaacatc aatctccgtt
    18901 ttgaaaaagg acaagttgtt gtcctgcttg gaccttctgg ctctgggaag tccactctta
    18961 tccgtacgat caatggttta gaggctgttg acaaaggaag tctcctagtc aatgggcacc
    19021 aagttgctgg tgccagccag aaagatttgg tacctcttcg caaggaagtc ggcatggttt
    19081 ttcaacattt taacctttat ccacacaaaa cagtgttaga aaacgtgaca cttgcgccca
    19141 ttaaagttct aggaattgat aaaaaagaag ctgaaaaaac cgccaaaaaa tatctggaat
    19201 ttgtaaatat gtgggacaag aaagattcct atcccgccat gctatctggt ggacaaaaac
    19261 agcggatcgc catcgctcgt ggtcttgcta tgcatccgga actcctcctc tttgatgaac
    19321 caacatctgc tcttgatcct gagactatcg gagatgttct agcagttatg cagaaactgg
    19381 cgcgtgatag gatgaacatg atcatcgtta cccacgaaat gggctttgct cgagaggttg
    19441 cggaccgcat tatctttatg gccgacggag aagttttagt agatacgaca gatgtcgata
    19501 acttttttga caatccaagc gaacctcgtg cccaacaatt cctcagcaaa attatcaacc
    19561 acgaaagtga caaagtcaaa taaggaggcg cctatgaaaa aaaattcttt ttatcagcat
    19621 tattgattag ccttttcggc cttgctgctg ccaaaccagt ccaggctgat acaagtatcg
    19681 cagacattca aaaaagaggc gaactggttg tcggtgtcaa acaagacgtt cccaattttg
    19741 gttacaaaga tcccaagacc ggtacttatt ctggtatcga aaccgacttg gccaagatgg
    19801 tagctgatga actcaaggtc aagattcgct atgtgccggt tacagcacaa acccgcggcc
    19861 cccttctaga caatgaacag gtcgatatgg atatcgcgac ctttaccatc acggacgaac
    19921 gcaaaaaact ctacaacttt accagtccct actacacaga cgcttctgga tttttggtca
    19981 ataaatctgc caaaatcaaa aagattgagg acctaaacgg caaaaccatc ggagtcgccc
    20041 aaggttctat cacccaacgc ctaattactg aactgggtaa aaagaaaggt ctgaagttta
    20101 aattcgtcga acttggttcc tacccagaat tgattacttc cctgcacgct catcgtatcg
    20161 atgccttttc cgttgaccgc tctattctat ctggctacac taataaacgg acagcactac
    20221 tagatgatag tttcaagcca tctgactacg gtattgttac caagaaatca aatacagagc
    20281 tcaacgacta tcttgataac ttggttacta aatggagcaa ggatggtagt ttgcagaaac
    20341 tttatgaccg ttacaagctc aaaccatcta gtcataccgc agattaagga ggatacccta
    20401 tgacagattt atcatcttgg acagcctatt ttcaggattt tggacaattt ttcaatggtt
    20461 tcctctttac tcttgcccta gcgattggat cctttatcct cgccatggtc ttaggaatct
    20521 tctttggtgc catgtcaacc agtaaacgtc caattttacg cattttagct cgcatctttg
    20581 tggaatttta ccaaaatact cctctcttgg tgcagtttgt tattgttttt tatggcctac
    20641 ctcttatcag tgaccatatc atcatgattc caatttattg gacagccgtt ctctgcgtgg
    20701 gactctatca cggcgcttat atcgctgagg ttattcgttc agggattcag tctattccta
    20761 gtggtcagat ggaggccgcc ttgtcgcaag gttttaccta tatcagtgcc atgcgcttga
    20821 ttaccttgcc tcagaccttc cgcatcattc tccctccatt gaccaaccaa attgttaacc
    20881 tcatcaagaa cacctctact gtagctatca tctctggagt agacttgatg tttgtgacta
    20941 agtcttggtc ggctctcaac ggaaactata tcccagcctt tttaggtgct actcttctct
    21001 actttgccct atgcttccct gttgcccagt ttggtcgcaa gatggagcaa gccaacaaaa
    21061 aagcctattc actttaggag gttactatgg aatctatttt agaagtttta accccagata
    21121 acctagtctt tatctttaaa ggatttggct tgaccctcta tatttctctg attgccatca
    21181 tcctctctac tatcatcggt acggtgctag ctgtcatgag aaatggcaaa aatcctgtct
    21241 tgcgaatcat ctccagcatt tatatcgaat ttgtgcgcaa cgttcccaac cttctctgga
    21301 tttttactat ctttttggtg ttcaaaatga aatccacacc agcaggtatt acagccttta
    21361 ctctctttac atcagcagcc ttggctgaga ttattcgagg cggtctcaat gccgtagaca
    21421 agggacaata cgaagcagga atgtcacaag gcttcacctc agcccaaatc ctctactaca
    21481 tcattctccc acaagccatc cgcaaaatgc taccagccat catttctcag tttgttaccg
    21541 tgattaagga taccagcctc ctctactctg ttatcgccct acaagaactc tttggagcca
    21601 gccaaattct catgggccgt tatttcgaac cagagcaggt cttcagtctt tgcatcctga
    21661 ttgccctcat ctacttcagc tttaacctag caatttctag cctgtctcat atgctagcca
    21721 aacgttggca acaagctgca gaataatact cttcgaaaat ctcttcaaac cacgttagct
    21781 ctatctgcaa cctcaaaaca gtgttttgag caacttgcgg ctagcttcct agtttgctct
    21841 ttgattttca ttgagtataa acagccactc tccagttcaa ttggagagtt ttttgatgag
    21901 agtagatatt tatagacctc aatttgacac catacatttt ctatgataaa atgtaacaaa
    21961 tttatttaca acaaatcgaa atctaaatga aatggaattt tctatgaaat cagtcaaagg
    22021 actactcttt atcatagcta gttttatctt gactcttttg acttggatga acacttctcc
    22081 ccaattcatg attccaggac tagctttaac aagcctatct ctgactttta tcctagccac
    22141 tcgtctccca ctactagaaa gctggtttca cagtttggag aaggtctaca ccgtccacaa
    22201 attcacagcc tttctctcaa tcatcctact aatctttcat aactttagta tgggcggttt
    22261 gtggggctct cgcttagctg ctcaatttgg caatcttgcc atctatatct ttgccagcat
    22321 catccttgtc gcctatttag gcaaatacat ccaatacgaa gcttggcgat ggattcaccg
    22381 cctggtttac ctagcctata ttttaggact ctttcacatc tacatgataa tgggcaatcg
    22441 tctccttaca tttaatcttc taagttttct tgttagtagc tatgcccttt taggcttact
    22501 agctggtttt tatatcattt ttctatatca aaagatttcc ttcccctatc tagggaaaat
    22561 tacccatctc aaacgcttaa atcacgatac tagagaaatt caaatccatc ttagcagacc
    22621 tttcaactat caatcaggac aatttgcctt tctaaagatt ttccaagaag gctttgaaag
    22681 tgctccgcat cccttttcta tctcaggagg tcatggtcaa actctttact ttactgttaa
    22741 aaattcaggc gaccatacca agaatatcta tgataatctt caagccggca gcaaagtaac
    22801 cctagacaga gcttacggac acatgatcat agaagaagga cgagaaaatc aggtttggat
    22861 tgctggaggt attgggatca cccccttcat ctcttacatc cgtgaacatc ctattttaga
    22921 taaacaggtt cacttctact atagcttccg tggagatgaa aatgcagtct acctagattt
    22981 actccgtaac tatgctcaga aaaatcctaa ttttgaactc catctaatcg acagtacaaa
    23041 agacggctat cttaattttg aacaaaaaga agtgcccgaa catgcaaccg tctatatgtg
    23101 tggtcctatt tctatgatga aggcacttgc caaacagatt aagaaacaaa atccaaaaac
    23161 agagcttatt tacgaaggat tcaagttcaa ataagtaatc atactctcct gggatttccc
    23221 aggagagttt tttatagcca aatgaaataa gacaggaacg atggaatttt ggcattcaaa
    23281 tcaattgata agaatgtttt atagtggagt gaaataggat acgaacaaat tgattaggaa
    23341 aatcaaatga atttatagaa atcttttagc agttatgttg tcctattcta gtttcaaaac
    23401 gctatagaag cagcattgtg ctagtctaga ttcagtttac tatactaaaa cgagtagctt
    23461 gaaatcaaaa aacccaccct cacaggcagg ttttatctgt attattcagc tagattatgc
    23521 tttaccttct gaaccgaata cgtcgatacg ttcttcaacc gatgcttgga tagcttttac
    23581 accgtcagcc aagaatttac gtgggtcgaa gagttttttc ttgtcgtatt ctgcttcgtt
    23641 tgcttcgtag tcacgagcaa atttacgagt tgcgttagcg aatgcgattt ggcattctgt
    23701 gttaacgtta actttggcaa caccaagttt gatagctgct tggatttgct catcaggaat
    23761 acctgatcca ccgtgcaata cgattgggaa tcctggaaga gcttctgtca atttttgcaa
    23821 gtggtcaagg tctagacctt cccagtttac tgggtaaggg ccgtggatgt taccgatacc
    23881 agctgccaag aagtcgatac cagtttcaac cattgcttta gcgtcttcga ttggagccaa
    23941 ttcaccttta ccgatgattc cgtcttcttc accaccgata gtaccaactt cagcttctac
    24001 tgagatacct ttagcgtgtg ctttttcaac aacttcttta gccaatttaa ggttttcttc
    24061 aactggaagg tgtgaaccgt caaacatgat tgaagtataa ccaacttcga tacactcaag
    24121 tgcatcttcg tagtgaccgt ggtcaaggtg gatagctact ggtacagtga tacccattga
    24181 ttcaacaagg ttagcgatca agttgcgagc aactttgtaa ccacccatgt atttagcagc
    24241 acccattgaa gtttggatca aaactggagc ttttttagct tctgctgcgc gcaagatagc
    24301 ttgagtccac tcaaggttgt ttgtgttaaa tccaccaact gcataaccgt tgtcacgggc
    24361 tgcttggaca aatttttctg ctgaaacgat tgccatttta tcaggcctcc tgtatatttt
    24421 tatgggtcat cccatttaca ttgttcattt tatcactttt tgccaaaaaa atctagtttt
    24481 tcccgcagtt tcgattgatt ttcttctaac tccatctatg taaacccttt ctccctagtc
    24541 ttggacgact tttggaaaat ctataaagaa ggttaaacga ttctcctcca tctcgaaacg
    24601 ataagctaat ttttcatgtt ctaatagact cttaaccaca aagagcccca taccagaccc
    24661 cttgaccttg cgactagcat tgtcagaaaa agactgggct agtttttctt gttcctctga
    24721 gctacagcta ttttcgataa aaagttctcc ttctctttct ccaattcgaa ctaagccacc
    24781 tggaacagag tgcttaatgg cattgctgat gagattagaa agaatcaact tcataactga
    24841 tgggtttaga taagcctgct gatgggtcaa actattgtct atctggagct ctctttcctt
    24901 tgctagcaag gcataatctt tgaccagatt ttgcgtcatc tggaggaggt caattgtttc
    24961 cctatcatct cgcaattcct gcacagaaga gagggaaagt atctgcagaa catggtgatt
    25021 gagttcatcc acaatcccca aggcaactcc cagatactgg tctctatcct tataacgacc
    25081 gatattctct ctcatatttt cgattaggat tttcaaacta gccagcggtg ttttcaattc
    25141 atgagaagct cctcgtagga attcgacctt catcttctcc agctggagaa tggcttcatt
    25201 cttttcatgc aagtccgcaa taacagtcaa gagatgctgg tagaggctat tgatttgttc
    25261 cttgagatta cctatctcat ccttagaatc cacgcgcaat cgcacttggg aatccaggtc
    25321 catcatccga cgggtcaccc gcttgatttc caaaatcggt gcaacaatag tccgagcgta
    25381 gatgtaggcc accaagaggg aaatcagaaa ggaggccagc aaggtatagg gaagaaactg
    25441 gagactgatt tgctccgctt ccttttgtaa atccatggaa gctagaaact ggagaatcat
    25501 agtaccaccg tcttgcgttt tcacctcgcg ctcctcaata aagagagagg ttgtctggcg
    25561 gtctgtgtcc agaggaagac tgtccttgac ttctaacttg tcctcggtca tctcaccttt
    25621 gacggtcccc ttgatatcac tagtctggga atacaagtct aacacttgct cgatactctg
    25681 cctatctttc ccttctaggg actgggcaat ggctgttgcc ttttgaccaa tggtttcctg
    25741 acgatgactc agataagtcg aaggaaaaag aaaataaata gctaaatgaa ggcagataac
    25801 cagaacacta aatatcgaga aggtatagat aaatatcttt gcaaataaac ctgttcgttt
    25861 cattttcgct ccaatttata accaacattg cgcacagtga ggatacaatc caagtctagc
    25921 tttttccgca attccttgat ataaacatca ataacacggt caaagggaac ctcatctgtc
    25981 gctttccaga cggcatcgat aatctgagat cgagtcaagg cccggccttc atttttcact
    26041 agatagtcca gaatttccaa ctctttggca ttgataggca cttcttgacc tgcgaggctt
    26101 gcactgtagc tttcaaagtc caccttggta tccttgtaag aaaagattcg tcctgtatcg
    26161 tagtagcgct tgaaaatcgc gtccaccctc acttttaaaa gggagaggga gaaaggtttt
    26221 tccagatagc catctgccaa agaggcaaag gcactcatct tgtattcctc atcttgaaaa
    26281 gctgtcaaca tcaagacagg aacctgactg gttttacgaa tctcagctag gacttctaag
    26341 ccgttgagct tgggcatctg gatatccagt aaaaccaggg ccacctcata gctagaaaat
    26401 tgctccagag cttcctgacc gtccgctgcc tcaatagttt catagccaca atccgtcaaa
    26461 taatcactga ccccctcacg gatcatctct tcatcttcta caattaaaat tttcatactt
    26521 taactgctct ctatttttta tttttcttag aataaatacc taccctattt tctattatag
    26581 tctcttgctg gccttttgtc tgcaagcaac tgaccactag ataaaacgtt gtgaaattcc
    26641 tttctcataa attccataac tttagtatat tatatttaag cactaaagta caaagaaagc
    26701 aactgaaagc aatgattttc accactgctt tcggatttat tttgaattgt taaatagcca
    26761 ttcctatcca ctattcttga atagaaacac aagatgcaat ctttattcta gactcatttt
    26821 ttcaaattta ttcaccatcc agcaagagct cttttggttg ttttctaagg agattgcttg
    26881 aagcaagcgc cataacgaga accactagaa ccaaggcaag gacaaaaatg atgataaagt
    26941 ctgatgtctg aatggaaatg tctaggctcg acaaggtctt gctaaagcca tctacttctg
    27001 caccaccacc aaggttagag gcttgagccg ccttactagc ctgtttggca acacctgaag
    27061 tcacattggc aaggacagtg tttccaattg cacgggcagt gtaattagct aggaagtaag
    27121 cagaaactag agcagggata gcaatcaaga tagattcggt gatgaattga cccaagatac
    27181 ttgcctgctt gaggccgata gagaggagaa ttcccacttc cttgcgacgg gcgttgatcc
    27241 aaaggctgag caagagggca aggaggagaa ctgagaagct caagctaccc cagaagagga
    27301 ggttggccat cttgtacata ccagagatag attgctcaag agctgggtag ttagaggagc
    27361 tcttgacgag tgtgtagctc ttccagttga taccactgat gccattcaac tctttcataa
    27421 catcatccaa gttcttgtct gctgttacaa agaaggttgc gtccccataa atggctgtgt
    27481 cttctgtgta tccataaagt tttgcagcag tgtgaatgtc tgtaatagct gtgttttcgt
    27541 aaagttcttg tgagtaggtt actgctgact tattatgacc atcaaagagt cccttgattg
    27601 tcacttcaac tgtttccttg gctccttttt cattatctgc atcgtagata ttagagtcca
    27661 gtttaacctt gtcccctact ttccagccgt gtttggctgc caagtccttg tgcaagagga
    27721 ttttatcctt gtcgtcgttg gttaagtgct ctccttcgac tagtttataa gaaccagaga
    27781 caaacttgtc ttctttagag gagtcattga cacctgtaat catcaagcta cttccaaaac
    27841 gcttggcacg atcagcagtg agattcttct tggtttctgg cgtttcaatc aggtcatatc
    27901 cagtcaaatc tccgatagcg ttgatacgtt tgacataaga ctcaatggcc ttgttttcgg
    27961 tgattttttt gatgtcttca cccttgatat tcccagcacc acgaggcgtt ccttggttga
    28021 cgcgacgatt gatttgcatg gagaagctat tggtgatatt tttaaaggtc tcctgagaag
    28081 ccttggcagt agctcccttg attgacaagc cgaccaaact caagctcgcc atgaggagaa
    28141 taatcaggaa gatgacaatc gatttgaaaa acttccttgt aacataggca aatgcgttgt
    28201 gtaacataga ttccctttct agattttgtt ttaatcattc tattaaaata agctcaaatt
    28261 atttactagt attgcgcgtt tcagtcagtt tcttatcctt taattcaagt gtaatatctg
    28321 acgcttgtgc cacttcttta ctgtgagtta cgacaatcac acatttacct gttttctggg
    28381 caagtgattt gagtagttcg acaatatctc cagcagtttt aggatccaga tttcctgttg
    28441 gctcatcagc tagaataact ggagcttctg agaccaaact gcgagcaatg gcaacacgtt
    28501 gctgttgacc acctgataac tggagaacat tccgcttgat ctggctttca tccaaaccaa
    28561 gctcaagaag tgtattcttg cttgcctttt tgttgaccaa tcggatattt tccagcggag
    28621 aaagataatc tatcaagtta taattttgaa agaccaggga aatatggtgc atgcgatggt
    28681 aagaatagcc cttcttacga atatcctctc cttgaaaaag gatagaacct tcaacaggac
    28741 tatctagacc agcaagtagg gacaagagtg tggattttcc tgctcctgac tccccaataa
    28801 tactgtaaaa ttttccgggt tcaaaattat aattgatctg atataggact gcttcagcag
    28861 tattcttata acggtaggta acatcttgta attgtaataa agtcatgatt tctccttctt
    28921 aactaataga tgataaaatt tctttcggtg attttctaaa taagaatagg aaacaaaggg
    28981 ctacagataa gcaactaagc agaactagaa aaacatagga ttctgcaaaa gataagatgc
    29041 tagttgataa actgcttgct ttggctagtg tatcttgtaa gcttgcctga tctccacttg
    29101 ctagtagagt ttggagtagg taagttgtga ttgcgtttcc tgcaacaaat gctggaagca
    29161 aagctccaag agataccaaa actacctcta aacagaattg taggaagatc gagctcttgc
    29221 cttttccaag tgcaagtaaa atccccactt catagacccg ttctctcaac cagagagaca
    29281 aaaccagaat taaggctcca gctcctgcta tcaacatccc ataaaggaag atggtcagga
    29341 aggtttggaa agttgcaact gagtctttga tttgttcaaa agccttgttt tccttttcga
    29401 cttggtagcc ttgattttcc aaggccaagt tttctacctg cttcatgagt ccgtccattt
    29461 ccttaggatt ttctacatag aagcgtgctg cactgacttg agcttcacta ttgcccaaaa
    29521 gggtttggct actttcatag tctgtaaaga cttgattttc actgaagtca gaagacaagc
    29581 ctgtgaattt ctcttgtttt ttaccagaaa agatgccgat aatctcaaac tctactgttt
    29641 gtccttttcc agattcagac tgaccagcat ccaagccaat cttgtcatga agcgaaagac
    29701 cgttcttctt agccaattct tcgtggataa ggattttctt ggaatcccct ttttgaaggt
    29761 gtcgcccttc ttttagattg aaagccgaac tggtaaaggt tacatccttg gatgaatcct
    29821 caagagccgt taagctaacc aagttattgt ctgcagctga taaatcatca cgctccacgc
    29881 tctgctcgcc agtcactgct tccttgtctt ttagttttgc gaccgtctca agttcaggag
    29941 agacattttc cagcccctta atcttgctta cagatgctag gtctgacaac ttgaatgtct
    30001 gaccattctc tatcttctta atagaaaaag atgtattgag tgatttataa agattgcttt
    30061 ctactgtttt gttggacttc atcagagtca aacaggctga aattccggcc aataagacca
    30121 ataaaatcag aaataaaata aaacttctca gtcgctttct gctgacataa gcccaagatc
    30181 tttggattgg attcatttgt cacctccata tttgtaagac tattataaaa cccaaatatg
    30241 aaatgtttat gaaatacgaa aaaaaaatat cgagtagggg ataatctcta gcccctctca
    30301 caccaccata cgtgccgttc ggcatacggc ggttcaacta acttttaacg catgtcgttc
    30361 aaggtaataa tccaaacacg aaaccagtcc acgtttttca aggactggtt ttgatatagc
    30421 acgtttaagt accgacttct gagctactat agtagattga aactagaata gtacacctct
    30481 acttctaaaa tattgttaga aatcgatttg actgtcctga acgattcgtc ctattcttat
    30541 ttcattttac tataattgat agtggtcgcc ccagccagat accttatctg ctatccattt
    30601 aggaacccct aacttaagca atccccataa tcgtctcgat ttcttcttcc attgcttcca
    30661 gataatcact cgtaggcgag tacgcaagcg ctcatctatg ctagtgacta tacttttcat
    30721 atttataatt cattcctttc gtttcactca aggcacaaca cagaatgaaa aagtgttgtg
    30781 atctttattt tgttttataa taatagtgag aaagcctatc actactacaa atcacgggga
    30841 ggtgaataag tgagtggtac agccactacc tcgcatattt tgtcacatca tttaacggta
    30901 cataataagt tgtaccatct gaataagttg ctacaatatc atttgcatgc tctccttcac
    30961 ctttagcaaa ggttggagct cctgctggat gatttttatt tgcctctttc aatttttcaa
    31021 taatggcatt ttttctgtat cttttatatt atcaggattt ttcactaaga ttttgtctgg
    31081 atatgtcggt ttagcagaaa caatttttac tgttatttct tttttattcg aagcacttgt
    31141 ccagtttcca gcattatctt tagcatttaa ttttacagta attcctgaac taggaacttc
    31201 agtagcaggt tgattatcaa cattattcaa ctttaatttc aaaagagctg ttgcatcaga
    31261 cgttttatca atcgttatat ataatgatga attgttatta taaccagttt cttcatattt
    31321 agctgtttgt gagctacttg aaacagaact gaaattatgc ccactacctc cctgattatc
    31381 ttcaatgctt acgtctaaat gaacttcccc actattattt ggcttagcaa caactgttat
    31441 agtaaaataa cataaaattt gcataaatag attaggtaaa tcaaagcaac ttctaggaat
    31501 gttttagcag tcacagtgta ctttcccagc atcaagccac tataactctg cacataaaaa
    31561 tggagaagat ggcaatcctc ttctccaaat attaacttct ttacaaacca actatagttg
    31621 acaaagaacc taaaatcaat tgataacaca aggtcaggtc ggtcaactct ttcaactgaa
    31681 gccctgtcaa ctcttcccat ttatcaatct tgtattggag agaattgcgg tgcagataga
    31741 gttgctgggc tgttttagtg agaacagcac tattttccca aagagagaga atgatttcct
    31801 gaatctgatc ttgatccaaa atcatctggt gtagacattc tttaattggc ttcaagtcca
    31861 cgagtctttc tcccatactc caaagataga gctgagaaaa agtatgaaca ccttggtgac
    31921 cctgacgcca ccatgtcttg aacaaatccc gctcagcttt gattaagtct gatagggctt
    31981 gatgtcctgt ctgagaccaa acctgaccca acatgataga aagacgaagt ccaaagtcat
    32041 actcaaccgc ttcaatcgta tcacttaaaa tatctcttac agaagtgtat ttgtcttgtt
    32101 gaagcacgaa aacataatcc tgagctccga cctgtagcac tgtctgacaa ttcggaaaaa
    32161 gagtccgcat catatctagc caagaagcca gattttcctg ctgaaaataa gaaagatggc
    32221 aataaaccaa ctgaatcttt ttaaaaactt gcggtgcctg tcccttgcct tcaaccagat
    32281 aggaatacca agggtttagc gaacgagcct gctcctgctg ggtcaaaagg gcaaccaact
    32341 gcttttcacg ctcgctgagc ccagcttcct ccagcaaaat ccactgctga gaagctaaag
    32401 ggagcgtgag atagccctct ttctctactg gttggtctga aatccgagcc tcaggaaacc
    32461 agtcttgtag ttcttttgcc ctcatgttct agccctccac tttttggatg caccatgaaa
    32521 ccaaactctc aagacgttcc agattctcag tcatatggag atagcccata accgcttcaa
    32581 atcccgtgga catacgataa gtcacgacat ctgcattttt agcctttgtg tggctattgg
    32641 tattgcggcc acgtttatag atttcttctt ctttttccgt taggacctgc tcctccaaca
    32701 tgagagcaat caggcgagcc tgagccttgg ctgacacata cttggttgct tcttgatgga
    32761 gtttattggg tttggtcata cctttgagga tgaggtgacg gcgaatatac atagaataca
    32821 ccgcatcccc ctcaaaggct agcgcaatcc cgttaatgag attgacatca atcacgtgtc
    32881 cacctcactc catcttttgt atccaatagt ttaatgcctt gagcagccag ttggtctcgg
    32941 atttggtctg ctgtctcaaa gtctcgattg gcacgcgcct cttggcgttt ttgaatcaag
    33001 tcttcaatct ctgcatccaa aacttcctca acaaagacaa ttccaaaaat ttctaacata
    33061 tctgcaagag cttgcttgac acttgcatca tagttccctg agttgatcca tttggccatt
    33121 tcaaagacaa ctgtgatacc gttggcagca ttaaaatctt catccatagc tgctacaaac
    33181 ttatctttaa agttttgtaa ctcttgggca tccacgtttc ctgtaaatgg ttgttcgtaa
    33241 gtattcttca gatacttgag attggtctcg gcatcgcgaa ctgccttttc cgtgaagttg
    33301 ataggcttac ggtagtgctg ggtcgcaaag aagaaacgaa gtacttgccc atcaagagtt
    33361 ttaagggcat cgtgtaccgt aatgaagtta cccaaggact tagacatttt gacattgtcg
    33421 atattgacaa agccattgtg catccagtag ttagcaaaag ccttgcctgt tttagcttca
    33481 gattgggcaa tttcattggt gtggtgtgga aactctaggt cagctccacc accgtggata
    33541 tcaatggtat cacctaaaat ctctgtcgac atgactgaac actcaatatg ccaacccgga
    33601 cgtccaggtc cccaaggact atcccaagaa atctcacctg gtttggaaga tttccataga
    33661 gcaaaatcta caggattttc cttacgagcc gtttcttcat cggtacgacc tgaagcacct
    33721 agatccaaat cttccaaggt tttattagcc aatttagcat agttgtggga tttttctaca
    33781 cggaaataga catccccttg actctcatag gcaaagcctt tctcgatcaa gtcttccaca
    33841 aaacggatga tgtctgccat aaactccact acacgcggat ggcgagtcgc aggtttcacg
    33901 cctaaggccg tcacatcctc acgaaaggca gcgatgtact tatccgcaac ctcctgaggc
    33961 gtgatgcctt cttccctggc acggttgata atcttatcat ccacatctgt aaaattggaa
    34021 atataggcaa ccttataccc acggtactca aaatagcgac gaatcgtatc aaaagctact
    34081 gtcgaacggg cgtttcccac gtggatatag ttgtacaccg ttggcccaca aacatacatc
    34141 ttgatcttgc cgtcctcaat cgggacaaat tctcgcaaat cacgagacat ggtgtcatag
    34201 attttaatca taaatcataa tcaggaaagc tgaaatccaa gaacaattag tttcatcact
    34261 aaaagttcaa gtaaatttca gtccgaatat ctctacactt cggaatccct tgctcctttc
    34321 tcattcagat aaaccacctg agtctgtttg acaaagccaa ttttttcata caaacgtttg
    34381 gcacctacat tgctatcttc cactgcaatc tgaaattcct tgtcattttg ctcaattagt
    34441 tggttgacga gggattttgc taagtagctt ccatagcctt ttccacgttc aggttccaat
    34501 attgctaaac cgtagaggta attcgtatta gtcgataaat caaccgtaca agttccaata
    34561 acctgaccag cttttaataa aatatatagt cggctttctg gatctttcag agcttcagcg
    34621 acatatctat ccacaacttc tctcgattca tgttcctctg aaaatgcctg aaattttaat
    34681 tgactaattt gatcctgata cgaactatct gctaacaaaa tttcaagatg ggaaacattt
    34741 gctaacggat aaggtcttct atccttacct aaccaagttt ctgtctcttc atcctcgatt
    34801 agtccccagt tactggcaaa gtcaggatga ttctctaaaa aaatacgttc tgtctgaaaa
    34861 gtgactgacc gaatggggaa agaagctgtt tctctctcaa aactagtaaa caatgcacgc
    34921 gcaatcccct gacggcgatg acctggatga accagtatcg tcacttctac atcttggtca
    34981 tctgcataga cagttaataa accaacaagt tcgccttttt cataataaag gaaaaaggcg
    35041 ggcatgtttg ggtcaaaatt aagcatgtta gagagatagg gatcgcgata ggtaccgtca
    35101 tagttttggc aacagttaat tacttttttc gcctcagata gctcctcttg gcttaacttg
    35161 tttcttgctt gaatcatata ggtatcctct acaaaccaga cgatctgtga ctggcatctt
    35221 tagcctgctc gagtttattg acataatact ctcgtttttc ttcgacttcg tgaatgacag
    35281 gctcatcttt cttaccatga agacggacaa tcttggccgg aataccgaca accgtcacgt
    35341 cactaggtac atctgctacg acaactgctg cagcaccgac cttggcattt tcaccaattt
    35401 ccacaggccc gataacttgg gcatgggctg atatgagggc tccctttcgt acagtcggat
    35461 ggcgtttgcc acagtctttc cctgttcccc cgagagtcac tccgtgatag agaagaacgc
    35521 ctttttcaac aatcgctgtc tctccaatca ccagaccaga accatggtca ataaaaacac
    35581 ctgaatcaat ctgggctcct ggatgaatct caatctgagt ccaaaagcgc caaaactgac
    35641 tgtacatacg agctaatagt ttgaagccgt gcttccagag aaaatgcgag agacggtggg
    35701 ccgccaaggc cttgacacct ggataagtca gcaaaacctc caaagtggtg cgggccgctg
    35761 gatcattttc ttttacaata tcaatggttt cgcgccacca ccccatacat ttctcctttt
    35821 cttattctga atcttttggt gtttctgtaa attctttctt aggtttgtaa tccttgtgat
    35881 gacgtgggcg gtgagggcgc tcagactttt cacctttttc atcatgctca ggttttggcg
    35941 gacgaggtag aagagccttc atagaggcat cgatacggcc tttttcatca atcttgataa
    36001 ccttaacatc aacttcatcc ccgatttcta ccaaatcctc tacacgattg gtacgagtcc
    36061 aagccatctc agagatatga acaagggcat ctgtcttatc aaagaggtta acaaaggcac
    36121 caaatttctc gatacgaacg actttagcac ggtaaacttc atccactttg gcttcacgaa
    36181 ccaaaccagc aataatttct ttggcacggt taatagcatc ttggtcacta gagtagatag
    36241 acacatttcc ttcttcgtct atatcaatct taacacctgt ttcagcgata atcttgtcga
    36301 tggtttctcc acccttaccg atgacaatct taatcttgtc cacatcaatc ttgatcgtat
    36361 caattttcgg agcagttgga gccaattcta gacgaacttc tggaatggtt gcttcaatga
    36421 catcaaggat ttcaaaacgc gctttcttgg cttgagcaag agcctccgtc aagatttctg
    36481 cagtaatccc ttgaatcttg atatccattt gaagggctgt aatcccatca cgagtacctg
    36541 caaccttgaa gtccatatct ccaaagtgat cttccaaacc ttggatatct gtcaatactg
    36601 tgtagttatt tccatctgag ataagtccca tagcaatacc agctactggc gccttgattg
    36661 gcacaccacc agccataagg gcaagagttc ccgcacagat agaagcttga gatgaagaac
    36721 cgtttgattc caaaacttct gctactagac ggatagcgta tgggaattct tccaagcttg
    36781 gcaagacttg agcaagagca cgctcaccaa gggcaccgtg accgatttca cgacgacctg
    36841 gcgcaccgta acgacctgtt tcccctacag aatattgagg gaagttatag tggtgcataa
    36901 agcgtttctt gtactctgga tccaaaccat caatgatttg agtttctccc atcggagcca
    36961 aggtcaagac tgaaagagct tgagtttgcc cacgagtaaa gagacctgaa ccatgtacac
    37021 gaggaaggaa gtcaacaacc gcatccaaag gacggatttc atcgacctta cgaccatcag
    37081 gacgcacctt gtcttctgta attaaacgtc gcacttctgc gtgttccatt tgttccaaga
    37141 tttcagccac atcacgcata atacggtcaa attcttcgtg gttcgcatat ttttcttcgt
    37201 aaacggcagt cacttggtct ttcactgctt gagttgcagc ttcacgggcc aatttctctt
    37261 ctacttgaac tgccttttgg aggtcactgt tgtaggctgc aatgatttca gcttgcaatt
    37321 cagcatccac gtgaagcaat tccacttctg ctttttcttt accgacagca gcaacgattt
    37381 cttcttggaa ggcaatcaat tctttgacag cttcgtgccc tttaagaagc gcttccaaca
    37441 tgatttcttc tgacaattct ttggcaccag actctaccat gttgatagcg tgcttggttc
    37501 cagctactgt caattcaaga agagattgct ctgcttgttc ttgacttggg ttgatgatga
    37561 tttggccatc tacatatccc acttgtaccc cagcaattgg tccgtcaaat ggaatatctg
    37621 aaatagacag tgccaaagat gaaccaaaca tagcagccat tggtgcagat gcattttcat
    37681 cataagaaag cactgtattg atgacttgga cttcattacg gaaaccttcc gcaaacatag
    37741 gacgaatcgg acggtcaatc aaacgcgctg tcaaggtcgc atctgttgaa ggacgtcctt
    37801 cacgtttcat aaagccacca ggaaacttcc cagccgcata cattttttct tcgtagttga
    37861 cttggagtgg gaaaaaatcc ccagttgcca ttttcttaga cataacggca gcagtcaaga
    37921 cagttgactc accgtaacgt acgacaacag agccatttgc ttgcttagca acctgaccag
    37981 tctctacaat taactcacga cccgcaaaag tcgtttgaaa cacttgtttt gccattttaa
    38041 tcccctttgg attgatgaaa ttatacgcct tgcctacaaa gatcaagata ccaaggacgt
    38101 caaaagcaaa gtaaaaatag gaaactgacg aagtcttcga tgaagacaag acagtttatc
    38161 ttttttacac agcttttcgg ccgtgttcaa ttactcaaga tgctaagccg tcaagcaact
    38221 caaaggaaaa taggaaatcg aacgacggag cgactgctcc taggcagatt tatctttttc
    38281 cacagagttg taggcgtgtt cagttttcaa gatacatcat tagaaaggtt taatattaaa
    38341 gtatctaaac ctttcacgct aatcgctatc gggcgattag ctaaatgctt tactaactct
    38401 ttcgtcaaat aacatcgatt tgactcactc gtgtcgttaa atcttacagt ttaaatgcat
    38461 tgtattattt aataccttca tctttgtatc aagtacgtac agaatctatt ttatcatatt
    38521 tttcttaaaa agtgaggtct ttaccattaa aaaggaacca ttcccctcac ctgagaagaa
    38581 tggtttgctt ttattatcct agagactggt gattaaacaa ggcatgggtt gcttgatgga
    38641 tgtattttgc tgtatcagca ttattcatcg tatagagatg cacaccggca acatcctgag
    38701 ttaccaagtc cacgatttgg tccactgcat aggcaagtcc tgctgctctg agcgactcag
    38761 ggtcatgctc atacttgtct aagatggctt taaatttgcg tggaagatgg atattctcac
    38821 aagtcttcaa gagtcggaga gcctgatttc gattcagaat tggcataatt cctgcatgaa
    38881 tgggaacatc aatcccagcc aagatacact tgtcctgaaa atcatagaag cgctcattgt
    38941 caaagaagag ctgagttacg aggctcgaac agcctgcatc cactttcttc ttaagatttt
    39001 gaatatctga aatctgattt ggcgaatctg gatgcccttc tggatagcaa gctccaataa
    39061 tatcaaagtg aggggtttgt tccttgataa actcaatcaa gtcggttgca tagcggaaat
    39121 ccttttgtgg ttccacgtct ggaataatat ccccacgaag agccaagatt ttctgcaccc
    39181 caactttgtc caagtcagca atagtttcag caaccttgtc cttagttaga taaatagctg
    39241 gcaagtgggc aatggtcgga atcgccaaat cattttggat aaagtcagcc aaacgaaccg
    39301 tcgtttcctt gatattaaat ttattattgc tggcagttac actgataaaa tggggagcca
    39361 actcctgcat atcctgcaag gctgaaataa tgttatcatt acccacggct gggtttggag
    39421 ggaacacttc aaatgagagt gacggtgttt ggcgtgacat atgtaataac cttttctagt
    39481 tgatttcttt ttgaacaacc actgtatgga gagaaatcca atcttacaat ttctcacgcg
    39541 cagctttagc tgcttcaaca aggcggatca agctttcttt tgtttctggg ataccacgtg
    39601 ttttcaaacc acagtcaggg ttgatccaaa ctttcttgct tggcacttta gcaaggatgg
    39661 cttcgattgt gttgtcgatt tcgccttcat ttggtacacg aggtgagtgg atatcgtaaa
    39721 ccccaggtcc cacttctgtt tggaagtttt tcgctttgag ttcgtccaag atttcaaggt
    39781 ttgaacggtt agcttcaaag gaaataacgt ctgcatccat gttatcgata gctgggatga
    39841 tatctgtaaa ttctgagtaa cacatgtgag tgtggatttg tgtgtctggc gctactgttg
    39901 agtgtaccaa gcggaaggca ggaatagccc agtcaaggta gtcttcgtac cagtcgctac
    39961 ggcggagtgg caatttttca cgaagagcag cctcgtcgat ttggatgatt ttcacaccag
    40021 cagcttcaag gtcaagtact tcatccttga tagcaagggc gatttggaga gttgaatcct
    40081 tgatagagat gtcttcacgt gggaatgacc agttaaggat ggtaacaggt ccagtcaaca
    40141 tacctttaac aggtttgttt gtacgacttt gtgcatagct agaccattta acagtgatag
    40201 ggttaagacg agtgacatca ccccagatga ttggtggttt taccccacgc ataccgtatg
    40261 attgtaccca tccattttta gagaagaggt atcctgacaa gttttgaccg aagtactcaa
    40321 ccatgtcatt acgctcaaat tcaccgtgaa caaggacatc aaagtcaata tcttcttgcc
    40381 acttgatcca ttcgtcaatc gtttcagcaa ggaaagcgtc gtactctttt tgagacaatt
    40441 cacctttacg gtaagccaaa cgtttggcac gaacttcttt tgtttgaggg aatgaaccaa
    40501 tcgttgttgt tggaagagct ggaagtttga aagcttcttc ttggatagct tcacgttctg
    40561 caaaggctgg caaacgagtg tagtctgcgt ctgtcaagcc agcgatacgc gcacgaagtt
    40621 cagcattttc accaacacgc tcagtcgcaa agagttcttt gttggctgca agagcttctg
    40681 aaccttgacc atttcggata gcatccaagt cacggatttc atccaatttt tcaactgcaa
    40741 aggcaaagtg gttcaagagt gctggttcaa attcttcatt agcagttgta aatggcacat
    40801 gaagaagtga gcaagagctt gtcaaaacga tgttttcagc tggaatttgc tcaagaacag
    40861 ccaagctctt ttcgtagttg ttgcgccaga tgtttttacc attgacaata cctacataga
    40921 gagtcttgtc agctgggaag ccacctttaa cgagttcaag agttttctta ccttcaacaa
    40981 agtcaagacc gatagcatct actggtaagt ttacaaggtc agcgtatacg tcacgaacat
    41041 caccgaaata agtttgaagc aagacttcaa gacctttttt gtcagccaag agtttgttgt
    41101 aaaggttcaa gaagagagct ttttcttcag ctgtcaagtc ttttacaaga gccgcttcat
    41161 ccaattggat gcgagtcgca ccaagttcag ccaatttagc aaaaacttct tggtaagcag
    41221 ccactaagct atctacgaag tcgtctgctt tcacgccttc ttcaaagtct gacaattgaa
    41281 ggaaagtgaa gggacctaca agaacaggac gagtgttcaa tccaagttct ttggcttctt
    41341 ggaactcatc gaaaatcttg tgaccagcca attttacttg agtgtctttt tcaaatttag
    41401 gaacgatgta gtggtagtta gtgttgaacc atttcttcat tggaagggcg cgaacgtccc
    41461 ctttttctcc ctggtaacca cgtcccaaag cgaagtagcg ctcaaggtca gacaagtcca
    41521 agttttgaac ggatgcaggc accacgttga aaaggaaagc cgcatctagg aagttatcat
    41581 agtgagaaaa gtcatttgat ggaatttcag tgatgccttt ttctttgaca atgttccagt
    41641 gtttagcacg caagtctttt gctgctgcta aaagttcttc ttctgagatt tcttttctaa
    41701 agtatttttc agttgtaaat tttaattcac ggaattcgcc caaacgaggg aaaccgatga
    41761 ttgtagttga catgatgtgt cctccaaaat ttgttgttga aactatctta acagaaaaga
    41821 aagcgtctgt ataattgtaa aaaattaggg tttgatatag tttgaaacta tatatctgtt
    41881 tcggacaaaa gaaaaagact tgaagcaaac gtctcaaatc ctttgtaatt cttactttac
    41941 agctatattc caattagaat actaaaacat gttattagta attcttataa gtgactatga
    42001 cctgttatta gaaaagacta taactgattc tagtcaactt tttccctgtt caagtgggac
    42061 gattgctagt gtctttccta aactggctag gacttttaag actgtatcca actgaggact
    42121 agtctttcct gtctccatcc tagctatgac aggctggctt attccactga cttcttccag
    42181 ctttttctga ctgattcctt gttcatacct agcctcaatc aactcgctca tgatagccac
    42241 tcgcatatca ctttcaagga tttcctcctt gctaaagagc tcagatggac atccttccaa
    42301 ttactcccaa tagcactatt cttcatcact taaccctctt ttttttacgt ctatgtattt
    42361 ttaaaaaaat gagcgaatta tgattcgata gattgaccag tgggtttaaa gttggtgcta
    42421 gcctatttct taagcgattt tccttttcta ggataaagca gttcctgctt gcttaacccc
    42481 aattttccac gatgaatcca atagtaaatg gttgaaattc ccacgttaac ccctttagcc
    42541 atcaccatca tttcaggcga aaatttttgg ttatgttttt ggttatgtat agtggagaat
    42601 cttttccttt agtttcttaa gactgttgag cgtagtcggc agaataaatc tctttgaagc
    42661 gcccttttcc aagacattgt cggactgtcc cacgcttgat ttcagtgtgg atagtttgag
    42721 gagcttttcc aagtagagag gcaatttctc tatttgattt tccttctttt ttccatcgtt
    42781 cgattaagcg acggctatcg attgtcaaat gtttgccttt tgtagtataa ttgtcttgca
    42841 tttctgtgcc ttttaatcat ttcaatctta aattggactt tttttacttg ggttgtactt
    42901 aatctatgag gaagacaaga aaaagaatat caatcaagta aagtcacaaa gtcacattag
    42961 ctccgagcaa ccattgcaaa ttgaggtact cacacaatga ttaaaacatt tctctctgcc
    43021 ctttcggtca ttctcttttc tatccctatc ataacttatt cttttttccc atcttctaat
    43081 cttaacattt ggctatctac ccaacctatc ttggcacaga tttatgcctt ccccttagct
    43141 actgcaacta tggctgctat tttaagtttc ttattttttt tcctatcttt ttacaagaaa
    43201 aataaacaaa tacggtttta ctctggcatt ttgctcttac tatcgctcat attactatta
    43261 ttcggaacag ataaaaccct ttcttctgca tcaaataaga ctaaaacctt aaaattagta
    43321 acttggaacg tcgctaatca aatagaagca caacatattg agcgaatttt tagccatttt
    43381 gacgccgata tggctatatt ccctgaacta gctaccaata tcagaggtga gcaagaaaac
    43441 cagagaatca aactattgtt tcatcaagtt ggactttcta tggccaacta tgatattttc
    43501 acttctccac ctaccaatag tggaatagct cctgtgactg tgattgtcaa gaaaagttat
    43561 ggtttctata cagaagctaa aacttttcat acaacacggt tcgggacaat tgtattacat
    43621 tcgagaaaac aaaatatacc agatatcatt gccttgcata ctgctcctcc tctgccaggt
    43681 ttaatggaaa tctggaagca agacttaaac atcattcata atcaattggc ttcaaaatat
    43741 ccaaaggcta ttattgcagg tgattttaat gcaactatgc gtcatggagc acttgcaaaa
    43801 ataagctctc atagggacgc attaaatgca ctgccacctt ttgaaagagg aacttggaat
    43861 agccaaagtc caaaactttt taatgcaaca atagatcata ttttattgcc taaaaaccac
    43921 tactatgtta aagatttaga cattgtaagt tttcaaaact ctgatcatag atgtattttt
    43981 acagaaatca cattttaatt attttatata aaatcacccc tctaatgttc ataaactaga
    44041 gggggaattt gtatcctact atcgtttaac gcacttctgc attcactttt tcttcgagag
    44101 acgcttggat tttttccata tagcgtgcga cttcttcgtc cgttaagctg tcttctggat
    44161 tttggaaggt caagctataa gccattgact tcataccaag tcccagtttt tcacctgaga
    44221 agacgtcaaa gagtttgata tctgtcaaac gtttcacgcc ggcagcttgg atagcatcta
    44281 caacttcttg gtgagtcact tctgccttga ggagaagggc aacgtcacgg ctgactgctg
    44341 ggaatttggt gatttccaca aatggaacag caggttggag cgccccttcg atggctgaaa
    44401 ggttaagctc agctacatac gtttctggaa tatcgtaagc cttggcagtg actggatgca
    44461 cttggccaag gaaaccaaga acttggtcac cgagtgaaat cacggctgta cgacctggat
    44521 gaaggctaac gatttcagat gttgctgtat aggttacttg gagtcccaaa cgagtaaata
    44581 gggcttcaag gattccctta gcatagaaga aatcaactgg aactgctgct gtttggaaat
    44641 ctttttcagc aaccaagcct gtcaaggcaa aggcaaagct gttgatctca tttggaagtt
    44701 cttcttttgg attacctgtt tgttcaaaga cttttccaat ctcataaagg gccaagtttt
    44761 tattcttacg agccacgttg taggcaacgg tatcaaggat ccctgaaatc atattttgac
    44821 ggaggactga acgatccaca gtcattggcc acatgagttc agtaaggtta cttggttgag
    44881 ctgtgaactc aactgctttt tcaggagttg tcagagcata ggtgatgatt tctgtcaaac
    44941 ctgctccttc agcaatggta cgaacttgac ggcggagttt ttgtatcaca gtcaattcac
    45001 cagctgtacc atcgtctttt ggaaggctgg ttggcaagcg gtcatatcca tagatacgag
    45061 cgatttcttc aaagagatca gcttcgattg tgatatccca acgacgacgt ggtacgctga
    45121 ctgtaaagct gtctgcattt ccagaaagac caaagccaag acgacggaag acgtcttcta
    45181 catcagcata agacagctca gttccgagga cacggttaac atcagcaagg gttgaagaaa
    45241 cttccacatc agaggtatca agctcacccg ctgaaacgat acccttacgc accgtcgcgc
    45301 ctgcaagctc tgcaatcatg ctagctgccg catcaagggc ttcattaact gttgccacat
    45361 taattccttt ttcaaagcga gaagatgact cagaacgaag gttcaggcga ccacttgtct
    45421 tacggataga tttgccatta aaaacagcag cttcaaggat aacacgacta gatttttcag
    45481 aaatttctgt agcctgacca cccataacac cggcaagggc tactggtttg tcagcaactg
    45541 taatcacgag gtctgtctca gccaagtctc gttcttcacc gtccagggtc actaattttt
    45601 caccatcacg cgcttcacgc acacggatgt cagtcccttc aaatgtgtcc aagtcaaaag
    45661 catgcatagg ttgaccaaag tagagcagga tgtagtttgt cacgtctaca acgttattga
    45721 tgggacggat gccttcgttc atgagaaggt tttgcaacca ttgtggactt ggtgcgatag
    45781 tcacattgtc caagatacga gctgcatagt aaggcgcctt gtctgtctca atgctgacag
    45841 aaagggcatc tgccgcagct tcattagttt ctgttagagt aaatttttta aagttgactg
    45901 ccttgtcata gatggctgcc acttcgtgag ccactccaca catagaaagg gcatctgcac
    45961 ggtttggtgt gatggaaagt tcgatgattt catcatccaa gtctaggtaa gaaaagactt
    46021 cctcacctgg cacggcatct tcaggcaaga tttggatgcc atctgcgaat tccttaggca
    46081 caactgagtc agaaattccc aattcaccaa gtgaacagat cattccaagt gactccaaac
    46141 cacggatttt tccttttttg attttgtagt tatcagcgat acgagctcct ggaagagcca
    46201 ccatgacctt gatcccagca cgcacatttg gggcaccaca aacgatctga cgctcttctt
    46261 cttcgccaac gttaatctga caaacatgga ggtgagtctc tggcacatct tcgcaagaca
    46321 agacctcacc gacgacaatt tttgagagac cagcagctgg tgattcgaca ccctctacct
    46381 cgatccctgt agttgacatt ttttcagcca actcttgtga tggcacatca atgtccacca
    46441 attcttttaa ccatttataa gatacaagca taatttagtt ctccagaatg acagttgtca
    46501 ctctagttct tttcctttcc tatcatttca atagaagaat cctcttctta ccttaatttc
    46561 tttctcagta accaatccgt atctactttt tgaccaacca taaaatgatg ttggctaaat
    46621 ttttcaaaac catatcggtt ataaaacgct tgagcttttg tattatgctc ccaaacacct
    46681 agccaagccc aagaaaaact attttttgta gcaagttcaa gtgcgaattc aaacagttgc
    46741 ttacctagtc caaatccttg gaatttttgt agcacataga gacgttgaat ttcaaaagcg
    46801 tcctctaatt ctctctcagt ttgagcactt ccccagttga ctttgagaaa accagctatc
    46861 tcctcctcat gcataatgaa ataggtttca gagtcaggat ttcccaactc agttgacaaa
    46921 gttttcagac tataagcctc ttcaaagtat tcctgtaact gctcttccgt attatcatac
    46981 gcaaaggttt cacgaaaggt ttgtttggca attttagcca acacctcaac atctgccatt
    47041 tctacttttc taatcattat ttaaactgtt ctgagaagcg gacatctcct tggtagaatc
    47101 cacggatatc gttgattcca taacggagca tagctacacg ctcttgtcca agaccaaagg
    47161 caaagccaga gtatacagtc gcatcgatac cactcatttc aaggacacgt gggtgaacca
    47221 taccggcccc cataatttcg atccaacctg ttttcttaca tacattacag ccttctccac
    47281 cacacttgaa gcaagaaaca tccacctcaa cagatggctc tgtgaatggg aagtaagatg
    47341 gacgcaaacg aatttgacgc tcttcaccaa acattttttg gacaatcaac tgaagcgttc
    47401 cttgaagatc agccatagag atatttttcc caactaccaa gccttcgatt tggtggaatt
    47461 ggtgactgtg ggtcgcatcg tccgtatcgc gacggaagac acgccctggc gagatcatct
    47521 tcaaaggacc tttagaaaaa tcatgggcat ccatagcacg cgcctgaact ggagacgtgt
    47581 gggtacggag caagatttct tcagtgatat agaaagtatc ctgcatatca cgagctgggt
    47641 ggtcttttgg aaggttcata cgttcaaagt tatagtagtc ttgctccact tcaaaaccat
    47701 ccacgacttg ataacccata ccgatgaaga tatcttcgat ttcttcactg gtttgtgtca
    47761 aaacgtgacg gtgaccagtc gcaactgg
//
LOCUS       DBMVGT010000008        47573 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.008, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000008 DBMVGT010000000
VERSION     DBMVGT010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 47573)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47573)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47573
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.008"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     regulatory      complement(71..159)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            complement(368..997)
                     /gene="thiE"
                     /locus_tag="AC0DU4_000483"
     CDS             complement(368..997)
                     /gene="thiE"
                     /locus_tag="AC0DU4_000483"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000468574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HIN4236492.1"
                     /translation="MFHKELLKLYFICGTTTCQGKNLYTVVEEALKGGITLFQFREKG
                     EGALEGLEKLELAIQIKELCKKYNVPFIVNDDIDLAMEIDADGVHVGQDDIGVDEIRK
                     LMPDKIIGLSIKNEEEFQQSKVEYVDYVGVGPVFDTQSKDDAGGAIGYEGLELMRKLL
                     PQMPLVAIGGIQTKHIKDIIKTNVDGVSIISAISYAKNIEKTVREMSEQ"
     gene            complement(999..1781)
                     /gene="thiM"
                     /locus_tag="AC0DU4_000484"
     CDS             complement(999..1781)
                     /gene="thiM"
                     /locus_tag="AC0DU4_000484"
                     /EC_number="2.7.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004417 - hydroxyethylthiazole kinase
                     activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HIN4236493.1"
                     /translation="MTSLKLLKEKAPLVICITNDVVKNFTANGLVALGASPAMSEFPA
                     DLEDLLKYAGGLLINIGTLTDENWKLYQAALKIAEKYNVPAVLDPVACGAGEYRKKVA
                     DDLINNYKLAAIRGNAGEIASLVGIDVASKGVDSAGVDNIDEIALAANEKFNIPIVVT
                     GEVDAIAVNGEVVTIHNGSAMMPKVIGTGCLLGAVVASFIGLEKGQELKSLETAMLVY
                     NIAGEMAEKRPNGHLPGTFKVEFINALYEITDEDVKEFKRVK"
     gene            complement(2024..2692)
                     /locus_tag="AC0DU4_000485"
     CDS             complement(2024..2692)
                     /locus_tag="AC0DU4_000485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000449895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TenA family protein"
                     /protein_id="HIN4236494.1"
                     /translation="METQDYAFQPGLTVGELLKSSQKDWQAAINHRFVKELFAGTIEN
                     KVLKDYLIQDYHFFDAFLSMLGACVAHADKLESKLRFAKQLGFLEADEDGYFQKAFKE
                     LKVAENDYLEVTLHPVTKAFQDLMYSAVASSDYAHLLVMLVIAEGLYLDWGSKDLALP
                     EVYIHSEWINLHRGPFFAEWVQFLVDELNRVDKNREDLTELQQRWNQAVALELAFFDI
                     GYNV"
     regulatory      complement(2907..2995)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            complement(3249..4385)
                     /gene="lctO"
                     /locus_tag="AC0DU4_000486"
     CDS             complement(3249..4385)
                     /gene="lctO"
                     /locus_tag="AC0DU4_000486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate oxidase"
                     /protein_id="HIN4236495.1"
                     /translation="MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTF
                     TLRENIRAFNHKLIVPHTLCDVENPSTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVA
                     TARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEG
                     YKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSP
                     RDVEFIAEYSGLPVYVKGPQCREDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQE
                     VAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLALGGSVGVRQVFEH
                     LNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY"
     gene            complement(5010..6500)
                     /gene="lysS"
                     /locus_tag="AC0DU4_000487"
     CDS             complement(5010..6500)
                     /gene="lysS"
                     /locus_tag="AC0DU4_000487"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004824 - lysine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006430 - lysyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HIN4236496.1"
                     /translation="MSTEHMEELNDQQIVRREKMAALREQGIDPFGKRFERTANSQEL
                     KDKYANLDKEQLHDKNETATIAGRLVTKRGKGKVGFAHLQDREGQIQIYVRKDAVGEE
                     NYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDVETI
                     YRKRYLDLISNRESFERFVTRSKIISEIRRYLDQKGFLEVETPVLHNEAGGAAARPFI
                     THHNAQNIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQ
                     AYADFQDIMDLTEGIIQHAAKSVKGDGPVNYQGTEIKINEPFKRVHMVDAIREITGVD
                     FWQDMTLEEAKTIAAEKKVPVEKHYTEVGHIINAFFEEFVEETLIQPTFVYGHPVAVS
                     PLAKKNPEDQRFTDRFELFIMTKEYGNAFTELNDPIDQLSRFEAQAKAKELGDDEATG
                     IDYDYIEALEYGMPPTGGLGIGIDRLCMLLTDTTTIRDVLLFPTMK"
     gene            complement(6640..6774)
                     /locus_tag="AC0DU4_000488"
                     /pseudo
     CDS             complement(6640..6774)
                     /locus_tag="AC0DU4_000488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120720.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="lactate oxidase"
     gene            6807..7145
                     /locus_tag="AC0DU4_000489"
                     /pseudo
     CDS             6807..7145
                     /locus_tag="AC0DU4_000489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384089.1"
                     /note="The N-terminal region of this protein, as described
                     by TIGR01726, is a three transmembrane segment that
                     identifies a subfamily of ABC transporter permease
                     subunits, which specificities that include histidine,
                     arginine, glutamine, glutamate, L-cystine (sic), the
                     opines (in Agrobacterium) octopine and nopaline, etc.;
                     incomplete; partial in the middle of a contig; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0015837 - amine transport [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
     gene            7122..7724
                     /locus_tag="AC0DU4_000490"
     CDS             7122..7724
                     /locus_tag="AC0DU4_000490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001197618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HIN4236497.1"
                     /translation="MGISILSVLLSMMFGTVMGIIMTSHSRIIRFLTRLYLDFTRIMP
                     QLVLLFIVYFGLARNFNINISGETSAIIVFTLWGTAEMGDLVRGAITSLPKHQFESGQ
                     ALGLTNVQLYYHIIIPQVLRRLLPQAINLVTRMIKTTSLVVLIGVVEVTKVGQQIIDS
                     NRLTIPTASFWIYGTILVLYFAVCYPISKLSTHLEKHWRN"
     gene            7725..8483
                     /locus_tag="AC0DU4_000491"
     CDS             7725..8483
                     /locus_tag="AC0DU4_000491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015424 - ABC-type amino acid transporter
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HIN4236498.1"
                     /translation="MSETILEIKELKKSFGDNPILQGLSLEIKKGEVVVILGASGCGK
                     STLLRCLNGLESIQGGDIFLDGQSIVENKKDFHLVRQKIGMVFQSYELFPHLDVLQNL
                     ILGPIKTQGRDKKEVTEEALQLLDRVGLLDKQHSFARQLSGGQKQRVAIVRTLLMHPE
                     IILFDEVTASLDSEMVREVLELINDLAQEGRTMILVTHEMQFAQAIADRIIFLDQGKI
                     AEEGTAHAFFTNPQTKRAQEFLNVFDFSQFGSYL"
     gene            8495..9360
                     /locus_tag="AC0DU4_000492"
                     /pseudo
     CDS             8495..9360
                     /locus_tag="AC0DU4_000492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765259.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine ABC transporter substrate-binding
                     protein"
     gene            complement(9447..10094)
                     /locus_tag="AC0DU4_000493"
     CDS             complement(9447..10094)
                     /locus_tag="AC0DU4_000493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236499.1"
                     /translation="MNEIITLKNIELKLKKTCVFQNLNFSCKQGEIIGITGANGSGKS
                     VLFKLIAGLYSPSYGEVLINGENIVPERKIPANLGALIEEPGFINYYSGFKNLQYLAS
                     IRGVVGNQEINDTLKIVGLYEQKDQKVKTYSLGMRKKLGIAQAIMENPSILLLDEPMN
                     ALDKSSVENMRTLFRKLSSEKGTTILIASHSEEDIRILCDKVYAIEDKVCTLCSD"
     gene            complement(10091..10789)
                     /locus_tag="AC0DU4_000494"
     CDS             complement(10091..10789)
                     /locus_tag="AC0DU4_000494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236500.1"
                     /translation="MGKLSSHMWRLNQIIYTKYFWGYVLFWILICLGLWYWLEGNDRL
                     VIEILKGPNLSQNSFLVLSIWLLHWFIIHTFFLAVVYRRRASDFFMEVIRFSSIKLWI
                     RYQIWTCFLYGLILIMVKVLVIQFMLQLANWDIGVLFIVDSLNACVLSLLCFMLYALG
                     ANVQMNFACVSFFLLMIVFGGLFVGNRTNYLFYILNRGNGDIGRDLFLQLLFLVFLFK
                     SIFYFTRQKRRFIE"
     gene            complement(10799..11551)
                     /locus_tag="AC0DU4_000495"
     CDS             complement(10799..11551)
                     /locus_tag="AC0DU4_000495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236501.1"
                     /translation="MKQFVQFYKKDFLAVLVYFILLLSCVLSSTVYLLRCRQYSIHPN
                     VLEWILVLLQDMTTGVYCFPFTYILFFFYLMNNYFNRLECRIRLKSIKHFTSFSFKLA
                     ALSTGIWTATLFLLIFLIAFSNGFSFSLEIKEVDFLREFYGISIANNASFFIGFFFSY
                     IAYYFFLSLLTISSFSWFKKSNMSLVFLFTFLFVESLFWIYQLNNGIIGLLPIFQYMV
                     NSNPYALIYWLTLLSIIIPLTVFSVHRNWRRV"
     gene            complement(11551..12315)
                     /locus_tag="AC0DU4_000496"
     CDS             complement(11551..12315)
                     /locus_tag="AC0DU4_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236502.1"
                     /translation="MEFFICNLVRVVQSPRFYMSLFLTLLCMSLGNFLAFNGIYKIEG
                     LSIFFAASSIRGFSPISLVAALICTLPYSSQIIEDAESHFLTAQLCRISKKRYLAIVG
                     STAIISSFLVFFLPYLLLLGINLLVTPYQEIYIGDYSGALKELFDSNQFLYSLVTTLW
                     YGVWGAVFSIFGLASALLVKKKLGAIFIPVAYMVVGGILWAILGLSYLEPVTTLALGY
                     QKDISLSLVSGHLAFILFVSCLVVYGTFFLHSEDYV"
     gene            complement(12411..12533)
                     /locus_tag="AC0DU4_000497"
     CDS             complement(12411..12533)
                     /locus_tag="AC0DU4_000497"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236503.1"
                     /translation="MYYNGGGDNYIGSGTRLAMAPQFGNHVRIHTSGSWSPDSY"
     gene            complement(12994..13626)
                     /gene="pyrE"
                     /locus_tag="AC0DU4_000498"
     CDS             complement(12994..13626)
                     /gene="pyrE"
                     /locus_tag="AC0DU4_000498"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004588 - orotate
                     phosphoribosyltransferase activity [Evidence IEA];
                     GO_process: GO:0009220 - pyrimidine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HIN4236504.1"
                     /translation="MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLA
                     YPETRTLIENGFVEAIKEAFPEVEVIAGTATAGIPHGAIIADKMDLPFAYIRSKPKDH
                     GAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKAD
                     KNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQENWQEG"
     gene            complement(13660..14361)
                     /gene="pyrF"
                     /locus_tag="AC0DU4_000499"
     CDS             complement(13660..14361)
                     /gene="pyrF"
                     /locus_tag="AC0DU4_000499"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001206708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004590 - orotidine-5'-phosphate
                     decarboxylase activity [Evidence IEA];
                     GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0044205 - 'de novo' UMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HIN4236505.1"
                     /translation="MREHRPIIALDFPSFEAVKEFLALFPAEESLYLKVGMELYYAAG
                     PEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKVLSQLGVDMTNVHAAGGVEMMKAARE
                     GLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEV
                     QLIKQATNPDFICLTPGIRPQGAAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEDPV
                     AAYHAIKDEWTQDWN"
     gene            14622..14894
                     /locus_tag="AC0DU4_000500"
                     /pseudo
     CDS             14622..14894
                     /locus_tag="AC0DU4_000500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_209629204.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(15096..15809)
                     /locus_tag="AC0DU4_000501"
     CDS             complement(15096..15809)
                     /locus_tag="AC0DU4_000501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000919282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236506.1"
                     /translation="MLKRFLALVWLRCQIILSNKSILLQVLVPFAFTYFCKYLMETQG
                     KVNDQQELVLLMMCLPFSLALAVGSPITIILSEEKEKYNLQTLLLSGVKGSEYILSTM
                     FLPFLLTFVIMGTTPLILGVTIVHTFNYITIVLLTSLSIILFYLLIGLTAKSQVVAQV
                     ISLPAMILVAFLPMLSGLDKTVAKITDYSFMGLFTKFFTKWEGFSWNETLIPNLTLLI
                     WIVLLLTLITITIRKKKIS"
     gene            complement(15802..16635)
                     /locus_tag="AC0DU4_000502"
     CDS             complement(15802..16635)
                     /locus_tag="AC0DU4_000502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236507.1"
                     /translation="MIEVSHLSKSFGDKIALNNISFTVKEGQIFGFLGPSGSGKTTTI
                     NILTGQFLADKGQSIILGQKSQNLTSGELKRIGLVSDTSGFYEKMSLYNNLLFYSKFY
                     NISKSRVDNLLKRVGLYDSRKMVAGKLSTGMRQRMLLARALINKPAVLFLDEPTSGLD
                     PTTSRTIHELILELKTAGTTIFLTTHDMNEASLLCDYVALLNKGKLVEQGAPSELIQR
                     YNKDKKIKVTDYNGNQITFDFTSLEQVSQADLENIFSIHSCEPTLEDIFITLTGGKLN
                     A"
     gene            complement(17117..18085)
                     /locus_tag="AC0DU4_000503"
     CDS             complement(17117..18085)
                     /locus_tag="AC0DU4_000503"
                     /EC_number="2.7.7.-"
                     /inference="COORDINATES: protein motif:HMM:NF013094.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HesA/MoeB/ThiF family protein"
                     /protein_id="HIN4236508.1"
                     /translation="MKELLEIEEVLGSKLTFELLNEQILISDEIDIDSRYSRTKGYYS
                     LFYNEEYNKIQNKTVLVLGAGALGCYISLSLSMYGVRKLIVADYDIIEPSNLNRQILY
                     TESDVGKEKINVLSEKIHKYNSDVQVVPISIKVSSLEELEKIVAEYGSIDFIVKAIDT
                     PIDIIKIVNQFAVSHKISYISGGFNGCYLIIDNIYIPTIGSCFGCRNINKDINKYTLS
                     DKTKWPTTPEMPAILGGIMTNLIIKIFLGCYNETLIDNAYVYNMRNHALSQEKYVLEN
                     GECPICKKNNKVKDNNIRAKTFIRSVCFCLLSGGVAFYLLLGSSLL"
     gene            complement(18187..18966)
                     /locus_tag="AC0DU4_000504"
     CDS             complement(18187..18966)
                     /locus_tag="AC0DU4_000504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase M50 family protein"
                     /protein_id="HIN4236509.1"
                     /translation="MKSRKKINIFKISWDFNITLSEKLNYKRFNKNFEKILFGIFPLA
                     LILQCFIMYIYRADILTNFQNFPITLNILLFWLLVVIISATIHEFSHAIIANNYQIEI
                     PNCGIMLLLFNLAFFVDLSGVQFLKNKKQFLKIMLAGIASNSILSLTGLLVLLFTSYK
                     LLGLLFFIINLGMIFINSIPFFQYDSGIILRYLNSNNNNLNFQYIVQLLIAFVIIYFP
                     LSQLLQFLTPNIIVRSIGGVVVSILLSILYMIGRTKYVLRK"
     gene            complement(19376..19498)
                     /locus_tag="AC0DU4_000505"
     CDS             complement(19376..19498)
                     /locus_tag="AC0DU4_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236510.1"
                     /translation="MQDNFLFEEIEEISVPVSDFSAGLATGIGFGLAILALAGC"
     gene            complement(19519..19644)
                     /locus_tag="AC0DU4_000506"
     CDS             complement(19519..19644)
                     /locus_tag="AC0DU4_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236511.1"
                     /translation="MSDEVFLFEEIEEIVAPTDGEFLGEVLLGTGVVLLIGVACC"
     gene            complement(19775..20974)
                     /gene="divIB"
                     /locus_tag="AC0DU4_000507"
     CDS             complement(19775..20974)
                     /gene="divIB"
                     /locus_tag="AC0DU4_000507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIB"
                     /protein_id="HIN4236512.1"
                     /translation="MSKDKKNEDKEILEELKELSEWQKRNQEYLKKKAEEEAALAEEK
                     EKERQARMGEESEKSEDKQDQESETDQEDSESAKEESEEKVASSEADKEKEEKEESES
                     KEKEEQDKKLAKKATKEKPAKAKIPGIHILRAFTILFPSLLLLIVSAYLLSPYATMKD
                     IRVEGTVQTTADDIRQASGIQDSDYTINLLLDKAKYEKQIKSNYWVESAQLVYQFPTK
                     FTIKVKEYDIVAYYISGENHYPILSSGQLETSSVSLNSLPETYLSVLFNDSEQIKVFV
                     SELAQISPELKAAIQKVELAPSKVTSDLIRLTMNDSDEVLVPLSEMSKKLPYYSKIKP
                     QLSEPSVVDMEAGIYSYTVADKLIMEAEEKAKQEAKEAEKKQEEEQKKQEEESNRNQT
                     NQRSSRR"
     gene            complement(20984..22042)
                     /locus_tag="AC0DU4_000508"
     CDS             complement(20984..22042)
                     /locus_tag="AC0DU4_000508"
                     /EC_number="2.4.1.227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0050511 -
                     undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase activity [Evidence
                     IEA];
                     GO_function: GO:0051991 -
                     UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-
                     glutamyl-meso-2,
                     6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol
                     4-beta-N-acetylglucosaminlytransferase activity [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0007049 - cell cycle [Evidence IEA];
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0030259 - lipid glycosylation [Evidence
                     IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA];
                     GO_process: GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine--N-acetylmuramyl-
                     (pentapeptide) pyrophosphoryl-undecaprenol
                     N-acetylglucosamine transferase"
                     /protein_id="HIN4236513.1"
                     /translation="MKKIVFTGGGTVGHVTLNLLLMPKFIEDGWEVHYIGDKRGIEHQ
                     EILKSGLDVTFHSIATGKLRRYFSWQNMLDVFKVGWGIVQSLFIMLRLRPQTLFSKGG
                     FVSVPPVIAARVSGVPVFIHESDLSMGLANKIAYKFATKMYSTFEQASSLAKVEHVGA
                     VTKVSDQKNPEPDELVDIQSHFNHKLPTVLFVGGSAGARVFNQLVTDHKKELTERYNI
                     INLTGDSSLNELSQNLFRVDYVTDLYQPLMELADIVVTRGGANTIFELLAIAKLHVIV
                     PLGREASRGDQIENAAYFVKKGYAEDLQESDLTLDSLEEKLSHLLSHKEDYQAKMKAS
                     KELKSLADFYQLLKKDLS"
     gene            complement(22046..23398)
                     /gene="murD"
                     /locus_tag="AC0DU4_000509"
     CDS             complement(22046..23398)
                     /gene="murD"
                     /locus_tag="AC0DU4_000509"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008764 -
                     UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
                     [Evidence IEA];
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HIN4236514.1"
                     /translation="MKVIDQFKNKKVLVLGLAKSGESAARLLDKLGAIVTVNDGKPFE
                     DNPAAQSLLEEGIKVITGGHPLELLDEEFALMVKNPGIPYNNPMIEKALAKGIPVLTE
                     VELAYLISEAPIIGITGSNGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQVAQIATD
                     KNTLVMELSSFQLMGVQEFHPEIAVITNLMPTHIDYHGLFEEYVAAKWNIQNKMTAAD
                     FLVLNFNQDLAKDLASKTEATVVPFSTLEKVDGAYLEDGQLYFRGEVVMAANEIGVPG
                     SHNVENALATIAVAKLRDVDNQTIKETLSAFGGVKHRLQFVDDIKGVKFYNDSKSTNI
                     LATQKALSGFDNSKVVLIAGGLDRGNEFDELVPDITGLKKMVILGQSAERVKRAADKA
                     GVAYVEATDIADATRKAYELATQGDVVLLSPANASWDMYANFEVRGDLFIDTVAELKE
                     "
     gene            complement(23502..24143)
                     /locus_tag="AC0DU4_000510"
     CDS             complement(23502..24143)
                     /locus_tag="AC0DU4_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236515.1"
                     /translation="MIELKNISKKFGSRQLFSDTNLHFEGGKIYALIGTSGCGKTTLL
                     NMIGRLEPYDKGQIIYDGTSLKDIKPSVFFRDYLGYLFQDFGLIESQTVKENLNLGLV
                     GKKLKEKEKISLMKQALNRVNLSYLDLKQPIFELSGGEAQRVALAKIILKDPPLILAD
                     EPTASLDPKNSEELLSILESLKNPNRTIIIATHNPLIWEQVDQVIRVTDLSHR"
     gene            complement(24145..26166)
                     /locus_tag="AC0DU4_000511"
     CDS             complement(24145..26166)
                     /locus_tag="AC0DU4_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000732428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HIN4236516.1"
                     /translation="MKKLFILLSTFFLSFFLAWIIVLRAPQYLYASYDSVSLLRVKKD
                     TQEPTREVFEQELENFANSEQSLIARRIVEPSKDGTTHFTYATYGQGTLPKEFQEASQ
                     ESRERSDPLNSYLLLSGSLTKEKLADKLGDLGYKASADRKIPPYFLAFRILLNPLILI
                     SLAIFGLSFFALVIITRIKEMRAAGIKLFSGQTLLSIMGHSLSTDIKWLLLSALLSFL
                     GGGVVLFSQGLFYPILLATYGFGISFYLLFLLAISILLMLLYLMSLNYKALVPVIKGR
                     LPLKRLMILTLLCQLVAVFTVGYAVKTGLTSYQRLKELEISKQAWQDRADYYQISFGL
                     GDRGKDTENQSKWYAFAKEAIEEEQALYVKDNLLHFANPQGKNEQGETLDTYSPDANT
                     LYVSPSYLDKEKVVVDAETKQKLAHLQKGEFILLLPEHLRSREAELKKVFEERLSYYG
                     KSGEEASAPLDYEMKAHVSYLSMGEKRFVYNNGENPVSTQYLTDPILVVFTPTSTGDS
                     FISLSSWSINAGKQLFIKGYESGLELLKKAGIYEQVSYLKEGRSVYLTRYNEVQTETA
                     TLILGAIVGIASSLLLFYSVNLLYFEQFRRDILIKRISGLRFFETHAQYMVSQFASFV
                     FGASLFILSSRDLVIGLLTLLVFLASAVLTLYRQAQKESRVSMTIMKGK"
     gene            complement(26237..26536)
                     /locus_tag="AC0DU4_000512"
                     /pseudo
     CDS             complement(26237..26536)
                     /locus_tag="AC0DU4_000512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397967.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
     gene            complement(26900..27154)
                     /locus_tag="AC0DU4_000513"
     CDS             complement(26900..27154)
                     /locus_tag="AC0DU4_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3165 family protein"
                     /protein_id="HIN4236517.1"
                     /translation="MVYLVLGILLLLLYVFATPESIKGTVNIVAMVCILVALLILLVL
                     SFLKIFQLPTEIFLAIAMLILAYFSVRDITLMPVKKSKRR"
     gene            complement(27174..29015)
                     /gene="typA"
                     /locus_tag="AC0DU4_000514"
     CDS             complement(27174..29015)
                     /gene="typA"
                     /locus_tag="AC0DU4_000514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003078415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA];
                     GO_process: GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HIN4236518.1"
                     /translation="MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAER
                     AMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPGHADFGGEVERIMKMVDGVVLVV
                     DAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQ
                     LDFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLD
                     YNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAG
                     DLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSR
                     KVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEV
                     IVKEIDGVKCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPA
                     RGLIGYSTEFLSMTRGYGIMNHTFDQYLPLIPGEIGGRHRGALVSIDAGKATTYSIMS
                     IEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTAVIKTPR
                     ILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE"
     gene            29177..29902
                     /locus_tag="AC0DU4_000515"
     CDS             29177..29902
                     /locus_tag="AC0DU4_000515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001235004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA pseudouridine(516) synthase"
                     /protein_id="HIN4236519.1"
                     /translation="MRLDNLLAQEKVSRKAMKQALLRGEILVDGCPARSLAQNIDTGL
                     QELLFQDRIIQGYEHTYLMLHKPAGVVTANKDKELPTVMDLLPSDIQSDKLYAVGRLD
                     RDTTGLLLLTDNGPLGFQLLHPQYHVDKTYQVEVNGLLTPDHIQAFQKGIVFLDGTVC
                     KPAKLEILSASPSLSQASITISEGKFHQIKKMFLSVGVKVTSLKRIQFGDFTLNPDLA
                     EGNYRPLNQKELQIIKNYLEMSR"
     gene            complement(29942..30169)
                     /locus_tag="AC0DU4_000516"
     CDS             complement(29942..30169)
                     /locus_tag="AC0DU4_000516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236520.1"
                     /translation="MKEKKKNPLFVGILSIILGLLFPIVGLILGIIGLVLAISYQKES
                     QLEYKIEKILNILGIVISVVNWIVAIALIFR"
     gene            complement(30258..30638)
                     /locus_tag="AC0DU4_000517"
     CDS             complement(30258..30638)
                     /locus_tag="AC0DU4_000517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HIN4236521.1"
                     /translation="MVTWILWALILAMLAWMGFNYLRIRRAAKIVDNEEFEALIRTGQ
                     LIDLRDPAEFHRKHILRARNIPSSQLKTSLAALRKDKPVLLYENQRAQRVTNAALYLK
                     KQGFSEIYILSYGLDSWKGKVKTS"
     gene            complement(30638..30907)
                     /locus_tag="AC0DU4_000518"
     CDS             complement(30638..30907)
                     /locus_tag="AC0DU4_000518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqgQ family protein"
                     /protein_id="HIN4236522.1"
                     /translation="MSLFLKKTQNFARMSLMKTFYDVQQFLKRFGIIVYMGKRLYDIE
                     LMKLELSRIYDAGLMDKLDYLEAEAVLRREHKVELDYIEKNGEKN"
     gene            30971..31879
                     /locus_tag="AC0DU4_000519"
     CDS             30971..31879
                     /locus_tag="AC0DU4_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HIN4236523.1"
                     /translation="MRIQQLHYIIKIVETGSMNEAAKQLFITQPSLSNAVRDLENEMG
                     IEIFIRNPKGITLTRDGMEFLSYARQVVEQTQLLEERYKNPVAHRELFSVSSQHYAFV
                     VNAFVSLLKKSDMEKYELFLRETRTWEIIDDVKNFRSEVGVLFLNSYNRDVLTKMLDD
                     NHLLSHHLFTAQPHIFVSKTNPLAKKDKVKLSDLENFPYLSYDQGTHNSFYFSEEILS
                     QEHHKKSIVVSDRATLFNLLIGLDGYTIATGILNSNLNGDNIVSIPLDIDDPIELVYI
                     QHEKTSLSKMGERFIDYLLEEVQFDS"
     gene            complement(31933..32688)
                     /locus_tag="AC0DU4_000520"
     CDS             complement(31933..32688)
                     /locus_tag="AC0DU4_000520"
                     /EC_number="1.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0070401 - NADP+ binding [Evidence IEA];
                     GO_function: GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HIN4236524.1"
                     /translation="MPTILITGASGGLAQEMVKLLPNDQLILLGRNKEKLAQLYGNYS
                     HAELIEIDITDDSALEALVTDLYLRYGKIDVLINNAGYGIFEGFDQIADKDIHQMFEV
                     NTFALMNLSRHLAARMKESSKGHIINIVSMAGLIATGKSSLYSATKFAAIGFSNALRL
                     ELMPYGVYVTTVNPGPIRTGFFDQADPDGTYLKSVDRFLLEADAVAKKIVKIIGKNKR
                     ELNLPILLNLAHKFYTLFPKLADKLAGETFNYK"
     gene            complement(32709..33638)
                     /gene="rnz"
                     /locus_tag="AC0DU4_000521"
     CDS             complement(32709..33638)
                     /gene="rnz"
                     /locus_tag="AC0DU4_000521"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000354350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016891 - RNA endonuclease activity,
                     producing 5'-phosphomonoesters [Evidence IEA];
                     GO_process: GO:0042780 - tRNA 3'-end processing [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HIN4236525.1"
                     /translation="MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQN
                     RILETTVRPRKISKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFV
                     LTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLE
                     GTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTR
                     KTNASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHIS
                     ARFLSKDISKLKKDAATIFENVHVVKDLEEVEI"
     gene            complement(33653..34276)
                     /locus_tag="AC0DU4_000522"
     CDS             complement(33653..34276)
                     /locus_tag="AC0DU4_000522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine beta-lyase"
                     /protein_id="HIN4236526.1"
                     /translation="MTDIKALALKYGGYTSLDKVYLVQLLAGKTEQEQLTLITPPPSV
                     VNAYFAELYQKKSPQAATDYFAELSQELNLYNTEPSFTLENKPFIRLNLSGKSFGFCY
                     DSDGLGRIFSENEEKISDDLLFEIAQIFPHQLVFEESGKIYMKPVEDEEVVSLESLTA
                     LTDLERLADGRKRLKGYSQEDLLQEAAAFSGKRYFRSENRTAMLYID"
     gene            complement(34269..35507)
                     /gene="hflX"
                     /locus_tag="AC0DU4_000523"
     CDS             complement(34269..35507)
                     /gene="hflX"
                     /locus_tag="AC0DU4_000523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HIN4236527.1"
                     /translation="MIETEKKEERVLLIGVELQGMDSFDLSMEELASLAKTAGAVVVD
                     SYRQKREKYDSKTFVGSGKLEEIALMVDAEEITTVIVNNRLTPRQNVNLEEVLGVKVI
                     DRMQLILDIFAMRARSHEGKFQVHLAQLKYLLPRLVGQGIMLSRQAGGIGSRGPGESQ
                     LELNRRSVRNQITDIERQLKVVEKNRATVREKRLESSTFKIGLIGYTNAGKSTIMNIL
                     TSKTQYEADELFATLDATTKSIHLGGNLQVTLTDTVGFIQDLPTELVSSFKSTLEESK
                     HVDLLVHVIDASNPYHEEHEKTVLSIMKDLDMEDIPHLTLYNKADLVEDFTPTQTPYT
                     LISAKSEDSRENLQALLLDKIKEIFEAFTLRVPFSKSYKIHDLESVAILEERDYQEDS
                     EVITGYISEKNKWRLEEFYD"
     gene            complement(35500..36384)
                     /gene="miaA"
                     /locus_tag="AC0DU4_000524"
     CDS             complement(35500..36384)
                     /gene="miaA"
                     /locus_tag="AC0DU4_000524"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0052381 - tRNA dimethylallyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HIN4236528.1"
                     /translation="MKTKIIVIVGPTAVGKTALAIEVAKRFNGEVVSGDSQQVYRGLD
                     IGTAKASPEEQAAVLHHLIDVREITESYSAFDFVSEAKMTIEDIHSRGKLAIIAGGTG
                     LYIQSLLEGYHLGGETPHEEILAYRASLEPYSDEELAHFVEQAGLEIPQFNRRRAMRA
                     LEIAHFGQDLENQETLYEPLIICLDDERSQLYERINHRVDLMFEAGLLDEAKWLFDHS
                     PNVQAAKGIGYKELFPYFRGEQTFEEASESLKQATRRFAKRQLTWFRNRMQVTFYQIG
                     ESGVQDRILSQIEEFLDD"
     gene            36505..36675
                     /locus_tag="AC0DU4_000525"
     CDS             36505..36675
                     /locus_tag="AC0DU4_000525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3042 family protein"
                     /protein_id="HIN4236529.1"
                     /translation="MAKGFAKGLVTGVAGTVAAVAGAVYAFKKKVIEPEEQKAAFIEE
                     NRKKAARRRVSR"
     gene            complement(36723..37562)
                     /locus_tag="AC0DU4_000526"
     CDS             complement(36723..37562)
                     /locus_tag="AC0DU4_000526"
                     /EC_number="2.1.1.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003011065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate synthase"
                     /protein_id="HIN4236530.1"
                     /translation="MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAF
                     SEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDT
                     GTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMF
                     DVRRIDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNL
                     HIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFD
                     LAI"
     gene            complement(37659..38618)
                     /locus_tag="AC0DU4_000527"
     CDS             complement(37659..38618)
                     /locus_tag="AC0DU4_000527"
                     /EC_number="2.7.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002919069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004340 - glucokinase activity [Evidence
                     IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA];
                     GO_process: GO:0051156 - glucose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family glucokinase"
                     /protein_id="HIN4236531.1"
                     /translation="MSQKIIGIDLGGTSIKFAILTTVGEIQGKWSIKTNILDEGSHIV
                     DDMIESIQHRLDLLGLAAADFQGIGMGSPGVVDRDKGTVIGAYNLNWKTLQPIKQKIE
                     KALGIPFFIDNDANVAALGERWMGAGDNQPDVVFMTLGTGVGGGIVAEGKLLHGVAGA
                     AGELGHITVDFDQPISCTCGKKGCLETVASATGIVNLTRRYADEYEGDAALKRLIDNG
                     EEVTAKTVFDLAKEGDDLALIVYRNFSRYLGIACANIGSILNPSTIVIGGGVSAAGEF
                     LLQGVQKVYDENSFPQVRTSTKLALATLGNDAGVIGAASLVLQ"
     gene            complement(38745..39743)
                     /locus_tag="AC0DU4_000528"
     CDS             complement(38745..39743)
                     /locus_tag="AC0DU4_000528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ltp family lipoprotein"
                     /protein_id="HIN4236532.1"
                     /translation="MNKRLFLKMSLVTLPILALFSQPVLAEENIHFSSCKEAWANGYS
                     DIHEGEPGYSAKLDRDHDGVACELKNAPKGAFKAKQSTAIQINTSSATTSGWVKQDGA
                     WYYFDGNGNLVKNAWQGSYYLKADGKMAQSEWIYDSSYQAWYYLTSDGSYAKNAWQGA
                     YYLKSNGKMAQGEWVYDSSYQAWYYLKSDGSYARNAWQGNYYLKSDGKMAKGEWVYDA
                     TYQAWYYLTSDGSYAYSTWQGNYYLKSDGKMAVNEWVDGGRYYVGADGVWKEGQASTV
                     SSSNDSNSEYSAALGKAKSYNSLFHMSKKRMYRQLTSDFDKFSNDAAQYAIDHLDD"
     gene            complement(39793..40410)
                     /locus_tag="AC0DU4_000529"
     CDS             complement(39793..40410)
                     /locus_tag="AC0DU4_000529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta fold hydrolase"
                     /protein_id="HIN4236533.1"
                     /translation="MKLIFLHGLGQSAESWKEVRNLLTDYPSEAIELFPSGVSNYQQA
                     KERVYQHLAQETEPFVLIGLSLGAALTLELSSYDLPNLRALILSGCPLKLAGNILFYL
                     QLLIFKLLPKRVFEKQGADKTLMVGVSEELKTLDLTDIAGTCSYPTLLICGSKDKPNL
                     SSMKALHRLLTDSQFQIIPDGPHVLNKAKPKEFVEKTRSFLELLK"
     gene            complement(40411..42132)
                     /gene="pabB"
                     /locus_tag="AC0DU4_000530"
     CDS             complement(40411..42132)
                     /gene="pabB"
                     /locus_tag="AC0DU4_000530"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046820 - 4-amino-4-deoxychorismate
                     synthase activity [Evidence IEA];
                     GO_process: GO:0008153 - 4-aminobenzoate biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HIN4236534.1"
                     /translation="MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADLLAQVESYQ
                     EQGYYVVGYVSYEAAPAFEEKLAVHKDPLLGEYLLYFTVHDSVETSPIPLTYEDIDLP
                     SNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEA
                     GYNAYVEHDEMAVISMSPELFFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDP
                     KNRSENMMIVDLLRNDMNRISEVGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLV
                     EIFRSLFPCGSITGAPKIATMEIIKNLEPQPRGVYCGTIGLLLPNGRRIFNVAIRTIQ
                     LHKGQAIYGVGGGITWDSTWESEYREVHQKAAVLYRKQARFQLITTGEISQKNLLFED
                     QHLERLRKASRYFAFPFDAEDLGHKIEEECQDCEANQDYRLRISLSKSGEIEVNRQVL
                     TPLSTSFCQAQVCLQEAALNQSFTYFKTTHRPHLSLGEQEKIYHNKSGELLETSIGNL
                     VLKIAGKLYTPPIRLGILPGIYRQHLLETGQVEEKVLTLADLTQAEAIYGCNAVRGLY
                     ELSLEEN"
     gene            complement(42193..47571)
                     /locus_tag="AC0DU4_000531"
     CDS             complement(42193..47571)
                     /locus_tag="AC0DU4_000531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000472960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005576 - extracellular region [Evidence
                     IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ZmpA/ZmpB/ZmpC family metallo-endopeptidase"
                     /protein_id="HIN4236535.1"
                     /translation="MGLVVLPSAGAVNPVATLALASREGVVEMEGYRYVGYLSGDILK
                     TLGLDTVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPKTEES
                     PKEEPKSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDK
                     PAEESKVEQAGEPVAPRKDEQAPVEPENQPEAPEEEKAVEETPKQEESTPDTKAEETV
                     EPKEETVNQSIEQPKVETPAVEKQTEPTEEPKVEQAGEPVAPREDEQAPTAPVEPEKQ
                     PEVPEEEKAVEETPKPEDKIKGIGTKEPVDKSELNNQIDKASSVSPTDYSTASYNALG
                     PVLETAKGVYASEPVKQPEVNSETNKLKTAIDALNVDKTELNNTIADAKTKVKEHYSD
                     RSWQNLQTEVTKAEKVAANTDAKQSEVNEAVEKLTATIEKLVELSEKPILTLTSTDKK
                     ILEREAVAKYTLENQNKTKIKSITAELKKGEEVINTVVLTDDKVTTETISAAFKNLEY
                     YKEYTLSTTMIYDRGNGEETETLENQNIQLDLKKVELKNIKRTDLIKYENGKETNESL
                     ITTIPDDKSNYYLKITSNNQKTTLLAVKNIEETTVNGTHVYKVTAIADNLVSRTADNK
                     FEEEYVHYIEKPKVHEDNVYYNFKELVEAIQNDPSKEYRLGQSMSARNVVPNGKSYIT
                     KEFTGKLLSSEGKQFAITELEHPLFDKIKAGTVKNINFENIDINVSNQDNIATIANEI
                     NGTTRIENIKATGTITARNNVAGFVNNIKENAALENVAFIGNINSVGNNSTVGGIAGS
                     NYMGFVNKAYVDANITAANASASMLVPLVTYMLNSYQYGTKSKVTNSVAKGTLDVKNT
                     RFVGGVVAKTWPWGVIKDIVTYAKVIKGEEVYGSNEINDGDARQFLSDIYRVNGASSG
                     ANNFTNLQKIKQLTKEQADAKVATFNITADKLESELSPLAKLNEEKAYSSIQDYNAEY
                     NQAYKNLEKLIPFYNKDYIVYQGNKLNKEHPLNTKEVLSVTAMNNNEFITNLDEANKI
                     IVHYADGTKDYFNLSSSSEGLSNVKEYTITDLGIKYTPNIVQKDNTTLVNDIKSILEP
                     VDLQSQTMYQHLNRLGDYRVNAIKDLYLEESFTAVKKNLTNLITKLVQNEEHQLNDSP
                     AARQMLRDKVEKNKAALLLGLTYLNRYYGVKFGDVNIKELMLFKPDFYGEKVSVLDRL
                     IEIGSKENNIKGSRTFDAFGEVLAKYTKSGNLDVFLNYNRQLFTNIDNMNDWFIDATK
                     DHVYIAERASEVEEIKNAKYRAYANLNVAQHRKMILPLLNITKSHMFIASNYNAIAIG
                     SAEKLGKKSLEDIKASVDYAADGYRNYYDFWYRLVPDNVKQYLLRDTVIPIWEGYNAP
                     GGWVEKYGRYNTDNVYTPLREFFGPIEKYYGYNGTGAYAALYDNPMDPRSDVSYVALN
                     MIGDYGISVYTHETTHINDRKIYLGGFGRREGTDAEAFAQGMLQLPVPGSGFNEYGSL
                     GLNTVFKKPNDGNQWYDTDPKSLTTRDDIDKYMRGYNDALMLVDHLEADAVINQNNKE
                     LNGAWFKKIDKKFRDASQLNQWDEIRNLTTEEKDNLNITSIDSLIDQQLMTNRQIGNR
                     VYKPEVVSQYDQSPYVGVEMTAGIYGGNTSKGAPGAVSFKHNAFRLWGYYGYLNGFLG
                     YTSNKYKQQSTKDGESVLSDEYIIKKISNNTFNTIEEFKKAYFKEVKDKATKGLTTFE
                     VNGSSVSSYDDLLTLFKEAVKKDAETLKQEANGHKTVSMTNTVKLKEAVYKKLLQQTD
                     SFKTSIFR"
BASE COUNT        14369 a        10051 c         8167 g        14986 t
ORIGIN      
        1 aaaaaactct aattacagat acgaattaga gttcagctta caagattaga cagttctttt
       61 cgacatacga aaaaaacatt tcacatttcc cttcgccagt cttaactgta tcaggttcaa
      121 tgggtatcat ctcagcctaa agcaccccaa atgcctttat tatttaatta tgtgattatt
      181 ataacacaca ttttatacta gttcaagaaa ttgaactgga aatacagcct tgcactcaca
      241 aagacagcag atctttcttt tgcaaaaaac aaatgacctg tttgatgaat taaccattca
      301 agctgaatct agacatagct ttttaaaaaa ggaaaatcct acttacttag aatccaagga
      361 tagatatcta ttgctcactc atttcccgaa cagttttttc tatatttttt gcatacgata
      421 ttgccgaaat gattgaaacg ccgtcaacat tggtctttat aatgtcttta atatgtttcg
      481 tctgtatccc accaattgca actaaaggca tttgtggcaa tagttttctc atcaattcaa
      541 gaccttcata acctatagca ccaccagcat catcctttga ctgggtatca aatacaggac
      601 caacaccaac ataatctaca tattcaactt ttgattgttg aaattcttcc tcgtttttta
      661 tagaaagacc aattatttta tctggcatca attttctaat ttcatcaaca ccaatatcat
      721 cttgacctac atgtacgcca tcagcgtcaa tttccattgc caaatcgata tcatcattaa
      781 cgataaacgg cacattgtat tttttacaaa gttctttaat ttggatagct agctcaagtt
      841 tttctaagcc ttctaaagca ccctcacctt tttctcgaaa ttgaaataag gttataccac
      901 cttttaaggc ttcctcaacg actgtatata gattttttcc ttggcaagta gtcgttccac
      961 aaataaaata tagttttagt aattctttat gaaacatctt acttcactct tttgaattcc
     1021 tttacatctt catctgtaat ctcgtataag gcatttataa attcaacttt aaatgtccca
     1081 ggaagatgtc catttggacg tttttctgcc atttctccag cgatattgta aaccaacatt
     1141 gctgtttcta atgatttcaa ttcttgacct ttttctagtc cgataaagct tgctaccact
     1201 gcccctaata agcatcctgt cccaatgact ttcggcatca tagcactacc attatgaatc
     1261 gttaccactt ctccattaac agcaatggca tccacttcac ctgttactac tattggaata
     1321 ttgaacttct catttgctgc tagagcaatt tcgtcaatat tatctacgcc cgcactatct
     1381 actcctttag atgccacatc tattcctact aaagaggcaa tctcgccagc atttcctcta
     1441 atcgctgcta gtttataatt gttgattaga tcatctgcta ctttttttct atattctcct
     1501 gctccacagg ctacaggatc taaaactgct gggacattat atttctctgc aattttcaga
     1561 gcagcttggt ataatttcca attttcatct gtcaatgttc ctatgtttat taataaacca
     1621 ccagcatact ttaacaaatc ctctaaatct gctggaaact cactcatggc tggtgaggcg
     1681 cccagtgcta ctaatccatt tgctgtgaaa ttttttacta catcattggt tatacaaatg
     1741 accaatggtg ctttttcttt taataatttt aaacttgtca tattgaaatc cttccttttc
     1801 actttatacg atctactgat ttcgatttat ttctatcttt cgttaagaat ttttttcatt
     1861 tacattgaat gatttatact caatgaaaat caaagagcaa actaggaggc taaccgcagg
     1921 ttgctcaaaa cactgttttg aggttgtgga tagaactgac gtggtttgaa gagattttcg
     1981 aagagtctta cctcatcaaa tttgtaaata tcatgagcct tctctagaca ttgtaaccaa
     2041 tatcaaaaaa agctaattct aaagcgactg cttgattcca gcgttgctga agttctgtca
     2101 aatcttctcg atttttatcg acacgattga gttcgtcaac cagaaattga acccactctg
     2161 caaagaaagg acctctgtgg agattgatcc attccgaatg aatatagact tcaggtaaag
     2221 ccaaatcttt agaaccccag tctaaataga gaccttctgc aatgaccagc atgaccaaaa
     2281 gatgggcata gtctgatgaa gccaccgccg aatacattag atcctgaaag gcttttgtta
     2341 cagggtgcaa agtcacttct agatagtcat tctctgctac ttttaactct ttaaaagcct
     2401 tttggaaata accatcttca tctgcttcaa gaaagcctag ttgcttggca aaacgaagct
     2461 tggattcaag tttatctgcg tgagctacgc aggcacccag catggataag aaggcatcaa
     2521 agaagtgata atcttgaatc agatagtcct ttaagacctt attctcaatt gtccccgcaa
     2581 aaagttcctt aacaaaacga tgattgattg cagcctgcca atccttctga ctgcttttta
     2641 ataattctcc aacagtcaaa cctggctgaa atgcatagtc ttgtgtttcc atatttactt
     2701 ctcctctctt tacttgttag taattaataa aacaccaaga aatatcaagc aaaatcgtaa
     2761 ttccacttga tccttttaaa gcacatcgag agcatttgca gagagctaac taaacaagcc
     2821 tatccagttt atataaacaa aaaactccaa ttacaatcaa gaattagagt tgacttacaa
     2881 gattagatcg ttcatttcgc catacgaaaa aacgtttcac atttcccttc gccagtctta
     2941 actgtatcag gttcaatggg tattatctca gcctaaagca ccccaaatgt ctctattatt
     3001 taattactga accagtatag caaaaaatga aagccctagc aagatatttg accgaaaaat
     3061 atctttatat ataatatatt gaaactagaa tagtacacct ctacttctaa aacattgtta
     3121 gaaatcgatt tgactgtcct gattgatttg tcctattctt atttcatttt actatagttt
     3181 tcgatagcaa tttattcttc caatacacga agaaaaacct ccacattcag tggaggcaat
     3241 ctgttttatc aatacaattt taagtcacga gggtcaactg ggaaggttgg gttgtatgga
     3301 ttgtgacgga gcttaaagtg tttgacatct tcaatggtct gagctccaga caattgcata
     3361 actgtcttca attccgcatt caagtgttca aagacttgac gcacaccgac actaccaccg
     3421 agagccaagc cataaataac agggcgacca atagctacca agtctgctcc tgaagccaag
     3481 gctttaaaga cgtgttgacc acgacgaaca ccagagtcaa agacaatcgg cacacgtcta
     3541 tcaactgctt ctgccacttc ttgaagcgag tcaaaggcag ctggtccacc gtcgatttga
     3601 cgaccaccgt ggttggttac ccagatacca gaagctcctg cagcaagtga acgttcaacg
     3661 tcctcacggc attgtggtcc cttgacatac acaggaagac cagagtattc agcgataaat
     3721 tctacatcgc gtggagacaa gcgttgttta gctgatttgt aaacaaagtc cattgattta
     3781 ccagcacctt ctggcaggta ttcttcaaca atcggcatgc caactgggaa gacaaaacca
     3841 ttacgcttat ccacttcacg attcccccct acagtagcat ctgccgtcaa gacaatcgct
     3901 ttataacctt cagccttcac acggtccatg atgtggcggt tgataccgtc atccttacta
     3961 aagtaaaatt ggaaccaatg gggtgtccct tgaagggctt cagaaatctc tggaaggtca
     4021 acagtagagt aagagctggt tgtataaaga gaaccaaact catgcacacc acgcgcagtc
     4081 gccacttccc cctgttcatt tgccaattta tgagccgcaa caggcgccat aatgattggt
     4141 gaagatagtt tttcacctgc aaattcaatc tctgtacttg gattttcaac atcgcaaagt
     4201 gtatgaggaa cgatgagttt gtggttaaag gcgcggatat tctctcttaa agtgaaagta
     4261 tcttccgccc cactagcgat atagccaaat gctgctttag gaataacttg ttgcgccatt
     4321 ggctccaaat cataggtatt gatgaagtct acatgacctt ctgcattgct tgttttgtat
     4381 gacataaaat gccctccttg attaagtaag cgtttgcttt ttactacaca actataataa
     4441 ctcttttttc aatcattttc aagagttttg cttaaaaacc atcttatttt ttcatacaat
     4501 atactagccc tactttcctt aaactctaaa ctttagtcta tattaagtga atcgttgaga
     4561 ttttttgctg ccaggcattt gaactacttt tttatttgcg gattctatct actaatacta
     4621 taaaaaaaca agtgaataag acaccagaac atcctctaat aggacctatg gacttatatc
     4681 agtcccatat atactgttta agcaagatac tatcctagtt gacgctaact tcctatccca
     4741 cttattaatt ttttatttat agtgaatctg aacaaatcaa ttggggaatc caagtcaatt
     4801 tctagtactt tttgaacagt ttcagcgtac tatcgtaaaa tgaaataaaa catgcacaaa
     4861 ttgcttaggg aatttaaacc aatttctaac aatgtcttag aaatcaaagt gtactatttc
     4921 aacttcaata tactacactt cattttctcc ttaaattcag tctctttttg aatcaaaaaa
     4981 tcccctggta agagccagag gataagaatt tatttcattg ttgggaagag caatacatca
     5041 cggatagttg ttgtatcagt gaggagcatg cagagacggt cgataccgat tcccaaacca
     5101 cctgttggtg gcataccgta ttcaagagct tcaatgtagt catagtcgat tcctgtcgct
     5161 tcatcatcac caagttcttt ggctttagct tgggcttcaa aacggctaag ttggtcgatt
     5221 gggtcgttca actcagtaaa ggcattaccg tactccttag tcatgataaa gagctcgaaa
     5281 cggtcagtaa agcgttggtc ttcaggattt ttcttagcga gtggagatac agctactgga
     5341 tgtccataga caaaggttgg ttggattaaa gtttcttcaa caaactcttc aaagaaggca
     5401 ttgatgatgt gaccaacctc agtgtagtgt ttctcaactg gaactttctt ctcagcagcg
     5461 atagttttag cttcttccaa agtcatgtct tgccagaaat cgacaccagt aatttctctg
     5521 atagcatcca ccatatgaac acgcttaaat ggttcgttaa tcttgatttc agtaccttgg
     5581 tagttgactg ggccatcgcc tttgactgat ttagcagcat gttggataat gccttccgtc
     5641 aagtccatga tatcttggaa gtctgcataa gcttggtaaa cttcgataga agtgaactca
     5701 gggttatgag tagcgtccat tccttcgtta cggaagatac ggccaatttc atagacacgt
     5761 tccataccac ccacaataag gcgttttaag tgaagctcag tcgcgatacg aagcaccatg
     5821 tcaatgtttt gggcattgtg gtgggtgata aatggacggg cagcagcacc accggcttca
     5881 ttatgaagaa caggtgtttc cacttcaagg aatccttttt ggtcaaggta acgacggatt
     5941 tcagagatga tttttgaacg agtgacaaag cgttcaaagc tttcacgatt agaaatcaag
     6001 tcaaggtaac gtttacggta aattgtttca acgtctgtca aaccatggaa tttctcagga
     6061 agaggacgaa gagccttaga caagtgtgtg atgtgggttg ccttgataga gagttctccc
     6121 atatccgtac gcatcacttc accttcgaca ccaaggaagt caccaaggtc tgcttttttg
     6181 aagatttcgt agttttcttc accgacagca tccttacgaa catagatctg aatctggcct
     6241 tcgcggtctt gaaggtgggc aaaaccaact tttcctttac cacgtttggt taccaagcgt
     6301 cctgcgatag tagctgtttc gtttttatcg tgtaattgtt ctttatcgag gttggcatat
     6361 ttatctttta attcttgtga atttgcagta cgttcaaaac gttttccgaa aggatcgatt
     6421 ccttgttcgc ggagcgcagc cattttttca cggcgaacga tctgctggtc atttagttct
     6481 tccatatgtt ctgtagacat gggatcctcc tagttttact caaaattgaa tacgatgagt
     6541 cattttttgc gatactccca ttttatcata aataagcaag aaattcacgg ataatcttta
     6601 aaaactaaaa agaacctgac gctaaaatca ctggaaagaa gtgaaagtat cttccgcccc
     6661 actagcgata tagccaaatg ctgctttagg aataacttgt tgcgccattg gctccaaatc
     6721 ataggtattg atgaaatcta catgaccttc tgcattgctt gttttgtatg acataaaatg
     6781 cactccttga taagtaagcg tttactttgt atattgcagt ttggggaagt ttgggatcct
     6841 ttctgctcgg tttaatcgtt agtatcatcc gacattatcg aatccctgtt ttggcgcaag
     6901 tagcgacagc ctacattgaa ttgtcacgta atacgcccct tttgattcaa ctcttctttc
     6961 tctacttcgg tcttccccga atcgggattg tcctatcttc agaagtctgt gcaacgcttg
     7021 ggcttgtctt tttaggaggc tccgccatgc aggattcggg aatccaagta ctctttcaag
     7081 gaaataatct cctgagaatc ttacagggat tgggcgttac gattgggata tccatcctgt
     7141 ctgtcctctt atccatgatg ttcggaacag tcatgggaat catcatgacc tcccattcta
     7201 gaatcatacg atttttaaca cgattgtatc tggactttac ccgtatcatg ccccagctgg
     7261 tgctactctt catcgtttac tttggcttgg ctcgaaactt taatatcaat atctcaggtg
     7321 agacttcagc tattatcgtt tttaccctct ggggaacagc tgaaatggga gacttggtac
     7381 gtggagctat cacttctctc cctaaacatc agtttgaaag tggacaagca ctcggcttga
     7441 ctaatgttca actttactac cacatcatca tcccacaagt cttgagaaga ctgctaccgc
     7501 aggctatcaa tcttgtcact cggatgatta aaaccacttc attagttgtt ttgattgggg
     7561 ttgtggaagt gaccaaagtt ggacaacaaa tcatcgatag caatcgcctg accatcccaa
     7621 ctgcttcatt ttggatttat ggaaccattc tagtcttata tttcgcagtt tgctacccta
     7681 tttccaaact atccactcac ttagaaaaac attggagaaa ctaaatgtct gaaactatct
     7741 tagaaatcaa ggaactaaaa aaatccttcg gagacaatcc catcctccaa ggactttctc
     7801 tagaaattaa aaaaggggaa gttgttgtca tcctaggggc atctggttgt gggaaaagta
     7861 ccctccttcg ttgcctcaac ggcttagaaa gtattcaagg tggagatatt tttctggatg
     7921 gtcagtctat cgttgaaaat aaaaaagatt ttcacctagt tcgccaaaag attggcatgg
     7981 tctttcaaag ttatgaactc tttccccatc tggatgtctt acaaaacctc atcctaggcc
     8041 ctatcaaaac tcaaggaagg gacaagaaag aagtaacgga agaagctttg caattactag
     8101 atcgtgtcgg tttgctggat aaacaacata gctttgcccg tcaattatct ggtggacaga
     8161 agcaacgtgt tgcaattgtc cgtaccctcc taatgcatcc agaaatcatc ctttttgacg
     8221 aggtgactgc ttcgctggat tcagaaatgg tgcgtgaggt gctggaactt atcaatgatt
     8281 tggcccaaga aggccgtacc atgattttag taacccacga aatgcagttt gcccaagcca
     8341 ttgctgaccg gattatcttc ctcgaccaag ggaaaatcgc tgaagaagga acagctcatg
     8401 ccttctttac caatccgcaa accaaacgag cccaggaatt tttaaacgtc tttgacttta
     8461 gccaatttgg ctcatatcta taaaggagat tcttatgaaa ctattcaaac cactcttaac
     8521 tgttttagca cttgcctttg cccttatctt tatcactgct tgtagctcag gtggaaacgc
     8581 tggttcatcc tctggaaaaa caactgccaa agctcgcact atcgatgaaa tcaaaaaaag
     8641 cggtgaactg cgaatcgccg tgtttggaga taaaaaaccg tttggctacg ttgacaatga
     8701 tggttcttac caaggctacg atattgaact agggaaccaa ctagctcaag accttggtgt
     8761 caaggttaaa tacatttcag tcgatgctgc caaccgtgcg gaatacttga tttcaaacaa
     8821 ggtagatatt actcttgcta actttacagt aactgacgaa cgtaagaaac aagttgattt
     8881 tgcccttcca tatatgaaag tttctctggg tgtcgtatca cctaagactg gtctcattac
     8941 agacgtcaaa caacttgaag gtaaaacctt aattgtcaca aaaggaacga ctgctgagac
     9001 ttattttgaa aagaatcatc cagaaatcaa actccaaaaa tacgaccaat acagtgactc
     9061 ttaccaagct cttcttgacg gacgtggaga tgccttttca actgacaata cggaagttct
     9121 agcttgggcg cttgaaaata aaggatttga agtaggaatt acttccctcg gtgatcccga
     9181 taccattgcg gcagcagttc aaaaaggcaa ccaagaattg ctagacttca tcaataaaga
     9241 tattgaaaaa ttagcaagga aaacttcttc cacaaggcct atgaaaaaac acttcaccca
     9301 acccacggtg acactgctaa agcagatgac ctggttgttg aaggtggaaa agttgattag
     9361 tcattaactc ttaaaaggaa ctggatttta agctccaatc cctttttaag attttaccta
     9421 taacatcctg agtctatcta agatgttcaa tctgaacaca gtgtacatac tttatcttct
     9481 attgcatata ctttatcaca taagatacga atatcctctt cactatgact agcaatcaaa
     9541 attgttgtcc ctttttcact agagagcttt ctaaacaatg ttctcatatt ttctacactt
     9601 gatttatcca aggcattcat aggttcatct agtaaaagaa tagagggatt ctccataatt
     9661 gcttgagcaa tccctagctt tttcctcata cctagcgaat aagttttaac tttctggtct
     9721 ttttgctcat atagaccaac tattttcagt gtatcattga tttcctgatt accaactact
     9781 cctcgtatgc ttgccaaata ttgtaaattc ttaaagccac tataataatt tataaaacca
     9841 ggttcttcaa tcaaagctcc caaattagct ggaatttttc tctcaggaac aatattttcc
     9901 ccattgatta acacttctcc ataagacgga ctatataaac cagctattaa tttaaacaat
     9961 acacttttac ctgagccatt cgcaccagta attcctataa tttccccctg tttacaacta
    10021 aaattaaggt tttgaaaaac acatgttttt tttaatttca actcaatatt ttttaatgta
    10081 attatttcat tcattctata aacctcctct tttgacgagt gaaatagaaa atgcttttaa
    10141 aaagaaagac taaaaatagc aactgaagaa ataaatctcg tcctatatct ccattccctc
    10201 gattcaaaat ataaaataga taattagttc gatttcctac aaatagacca ccaaacacaa
    10261 tcatgagtaa aaagaaacta acgcaagcaa agttcatttg tacattcgct cctagtgcgt
    10321 ataacataaa gcaaagcaag gatagcacac aagcattcaa agaatcaact ataaacaaaa
    10381 ctcctatatc ccagtttgct aactgtaaca taaattgaat cactagaact tttaccatga
    10441 ttaaaatgag tccataaaga aaacaggtcc aaatctgata cctaatccag agcttaatag
    10501 aagaaaatcg aatcacttcc ataaagaaat cggatgctct tctacgatat acaactgcta
    10561 gaaaaaatgt atgaataata aaccaatgaa gcaaccatat agataagact aaaaaagagt
    10621 tttgactcag attaggccct tttaaaattt ctataacaag tctatcattt ccttctaacc
    10681 aataccataa tcctaaacaa atcaatatcc aaaaaagaac ataaccccaa aagtacttgg
    10741 tatagattat ctgattcaac ctccacatgt gactacttaa ctttcccatt tccaactttt
    10801 acactctcct ccagtttcta tgaacagaaa atacagtcaa tggaattatg atagatagta
    10861 atgtaagcca ataaatcaat gcatacggat tggaatttac catatactga aaaattggca
    10921 ataatccaat tatcccattg ttcaactgat aaatccagaa taaggattct acaaataaaa
    10981 aagtaaacag aaatactaag ctcatgtttg attttttaaa ccaagaaaaa ctgctaatag
    11041 taagtaagga taaaaagaaa tagtatgcta tataagagaa aaaaaatcct ataaagaaac
    11101 tagcattgtt tgcaatactt ataccataaa attctcttaa aaaatcaacc tcctttatct
    11161 ccaaagagaa gctaaaacca ttactaaatg caattagaaa aatcaataaa aataaagtcg
    11221 ccgtccaaat ccccgtacta agagctgcta atttgaaact aaaactggta aagtgcttaa
    11281 ttgatttcag acgaatgcga cactccaacc tattaaaata gttattcatc aaataaaaaa
    11341 agaacaatat atatgtgaac ggaaagcaat atactccagt cgtcatatct tgaagtaaaa
    11401 ctaaaatcca ttctaataca tttggatgga ttgaatattg gcgacagcgc aataaatata
    11461 ctgtactaga taaaacacag gatagcagta atataaaata aaccaatact gctaagaaat
    11521 cttttttata aaattgaaca aattgtttca ttatacatag tcctctgaat gtagaaaaaa
    11581 tgtaccataa acaaccaaac aactaacaaa taaaataaaa gcaagatgcc cactaactaa
    11641 ggaaagactg atatctttct gatatcccaa agctagcgtt gtcacaggtt ctaagtaaga
    11701 tagccctaaa atagcccata aaataccacc aaccaccata taggcaactg ggatgaaaat
    11761 agctcctaat tttttcttca ctagcaaagc actagctagt ccaaaaatag agaacacagc
    11821 gccccaaact ccataccaga gagtcgtcac aagactatag agaaactgat tagaatcaaa
    11881 taattctttt aaggcaccac tataatctcc aatataaatt tcctgataag gagtcactaa
    11941 aagattaatt cctaataata ataaataggg gagaaaaaag actagaaaag aagaaataat
    12001 tgcagtacta cctacaatag ctagatacct ctttttagaa attcggcaca attgtgctgt
    12061 tagaaaatga ctctcagcat cctctattat ctgactagaa tagggcagtg tacagataag
    12121 tgcagctact aggctaatcg gtgaaaatcc tcgaatagaa gaagcggcaa aaaaaatcga
    12181 taaaccttca attttataaa taccattgaa agcaaggaaa tttcctaaac tcatgcaaag
    12241 aagggtcaaa aataaagaca tataaaaccg aggtgattga acgactcgta caagattaca
    12301 aatgaaaaat tccatcctta ctcctactta taataaaaat agggtgtagc attctttttt
    12361 catgctacac ccacaatcaa ccatctttaa ggcttactct gacaagtaag ttaataagaa
    12421 tctggactcc aagaacctga agtatgaatt cttacatgat ttccaaattg tggcgccata
    12481 gctaatctag taccagaacc aatataattg tcaccacctc cattatagta catgacaatc
    12541 ctagagccag accccaatga atataccggg gtaatatctg acccactata ggcgctacga
    12601 atagaggtat ttaacctttt accgccacca gtgctgtcac tattattaat tccagcagag
    12661 gcgttttctt tctcaagctc actagttgta tccgaacccc aacgcggcaa cgttaaatca
    12721 taatttccaa tctgtctagc taaaactgta gggagaaaca aactagatgc aattgtaact
    12781 acgcaaaaaa ggaatatatt tttcttcttt tcatgacatc gtcctcttaa gaagtgataa
    12841 acaagatagt tgattgatca atttgataca tattacattt tcattatatc aataaaagaa
    12901 agcgttgtca attattttat ttaaaatatt atcatatttt aaataaaatg gtaaaagaga
    12961 ctcggtagcc tcgtctctct ttatcttact gacctaacct tcttgccaat tttcttggtc
    13021 ttctttaaag cgttttagaa gatcaaggcc ctctggcgtg atgtaacctt cttcttgggc
    13081 tagatggata agctcgctat agtttgaaag cgtcacaagt ttaacaccag catctgcaaa
    13141 gttcttatct gcttttggca attggtagct gaaaatcgct acaactccaa gtacatctgc
    13201 tccttctcgc ttggctgctg ctacagcttc aagaactgaa ccacccgttg aaataaggtc
    13261 ttcaaccact accatttttt gaccttgagc tacgcgacct tcgatttgat taccagctcc
    13321 gtggtctttt ggtttgctac ggatgtaggc aaaaggcaag tccatcttat cagcaataat
    13381 ggctccgtgt ggaatccctg ctgttgcagt tcctgcaatc acttctactt caggaaaggc
    13441 ttctttgata gcttccacaa aaccattttc aattagggta cgagtttctg gataggctag
    13501 tgtcacacga ttatcagtgt aaatcggtga cttgatacca gacgcccaag tgaagggttc
    13561 ctctggtttg aggtaaacgg cttggatttt caagaggtgg ctagcgatat ctttagcaag
    13621 tgtcatggta ttctcctttt atttttctaa tctagttctt taattccagt cctgtgtcca
    13681 ttcatccttg atggcatgat aagctgcaac aggatcctca gcttgggtaa tgggacgtcc
    13741 cactacgata tagtcactac caatttgata agcatctgct ggcgtcatga cgcgtttttg
    13801 gtctccaaca gcagctccct gtgggcgaat ccctggtgtc agacagataa aatctggatt
    13861 ggtggcctgc ttgataagtt gaacttcctg tgccgagcaa acgacaccat ccaagcctgc
    13921 ttcagctgtc ttcttggcat agtggatcac agactcttgt aggcttgttt ggatattttg
    13981 aaactcctgc atctgggctt ctgatgttga tgtcagctgc gttacagcga tcaattttgc
    14041 ttgacttcca agaccttcac gcgcagcctt catcatctct acaccaccag ccgcatgaac
    14101 attggtcata tcgacaccaa gctgagacaa gaccttcatg gctgacttga ctgtattagg
    14161 aatgtcatga agtttgagat ccaaaaagac actatgaccc aaacctttta agtaggacac
    14221 aatctcaggc cccgctgcgt aataaagctc catccctacc ttgagataaa ggctttcttc
    14281 tgctgggaaa agagctaaaa attccttgac cgcctcaaaa ctaggaaaat caagagcaat
    14341 gattggacga tgttctcgca taggtttctc cttttacctt tactagtgag agagtctggc
    14401 caacagaagc cacgaaaaaa ggaacctgcc aacagcaagg ttccacgaaa aatgggtagt
    14461 ctccaccctt tcaccgtcta accttagctg cctctctgga ctgctttaaa ggttttctat
    14521 tattctatta tttctactag cacttgtcaa gtaaaaacat ggtcacgtat gtgttgactg
    14581 ctattgaaca cctcacaaga ctctttccaa aagaatagtt aaagactttc actgaggaca
    14641 gagaaaaaga gtttgcttgt taccctttaa ttgaacaaat gggaattctg ttttattttg
    14701 cggatgccta ttcatcttgg caaaggggaa gtaatgagaa tgcgaatgga cttcttcgtg
    14761 agtattttct taaaccgatt tggcaacaat taccgaaaaa atccttaatg gtgctttgct
    14821 agcttattaa tcaccgttcc caaaaatact tggattacaa gacaggtttt gaagcactta
    14881 tagaggagat ttaaaaatgt tgcatttttt attgcaattt atcagttatc ttatcaccca
    14941 aaacttctgc aattagtatg agcactattg ttatttttct tttttcgtac actcaaatca
    15001 aaatatagca ataagactat tctgtagaat tgctgtcaaa aagatcagtt catttttcct
    15061 tcccacttgt gtttataatc attaaaataa ctcaattaag aaattttctt tttcctaata
    15121 gttatcgtaa ttaaagttaa tagaagaaca atccaaataa gtagtgttag attaggaatt
    15181 agagtttcat tccatgaaaa tccctcccat tttgtgaaaa acttagtaaa cagtcccata
    15241 aaactataat ctgttatctt cgcaactgtc ttatccaaac cagatagcat cggtaagaaa
    15301 gcaactaaaa tcatagcagg aagactgata acctgagcta ctacttggct cttcgcggtt
    15361 aaacctatca ataaatagaa taaaatgatg gataaagagg ttagaagaac gattgtaata
    15421 taattaaaag tatgtacaat tgtaactcct aaaataagag gagtagttcc cataatcaca
    15481 aaagttagca aaaaaggaag aaacatcgtt gataaaatgt attcggatcc tttaacacca
    15541 ctcaacagaa gagtttgtaa attgtacttt tctttttctt cagacaagat aatagttata
    15601 ggacttccaa cagccaaagc caaagaaaaa ggtaaacaca tcatcaaaag aactaattcc
    15661 tgttgatcgt tgaccttccc ctgtgtttcc ataagatatt tacaaaaata tgtgaaagca
    15721 aaaggcacta aaacttgcaa taaaatactc ttattggaaa ggataatttg acaacgcaac
    15781 cataccaaag ccagaaaccg tttaagcatt tagctttcct cctgttaatg tgataaaaat
    15841 atcttctaaa gtaggctcac atgaatgaat tgaaaaaata ttttccagat cagcctgaga
    15901 tacctgttct agtgatgtaa aatcaaaagt tatctgattc ccattataat ctgtaacctt
    15961 aatcttttta tctttattat atctttgaat gagttcagaa ggagctcctt gctcaactaa
    16021 tttcccttta tttaataagg caacataatc acataaaaga cttgcttcat tcatatcatg
    16081 agtcgttaga aaaatcgttg tccctgctgt tttcaattct aaaattaact catgaattgt
    16141 tcgagaagtt gtgggatcta gacctgaggt cggttcatcc agaaagagta cagcgggttt
    16201 gttgataaga gctcgtgcta aaagcattcg ttgcctcatt ccagtggata attttcctgc
    16261 taccatcttg cgactatcat ataatcctac tcgctttaac aaattatcaa cacgtgattt
    16321 actaatatta taaaatttac tataaaaaag aagattgtta tacagagaca ttttctcata
    16381 aaatccactt gtatcgctaa ccaatccaat tctctttaat tcaccgcttg ttaaattttg
    16441 agatttttgt cccaaaataa tagattgtcc tttatcggca aggaactgcc cagtcagaat
    16501 attaatcgtt gtggtttttc cagaaccaga tggtcctaaa aatccaaaaa tctgaccttc
    16561 tttaacagtg aagcttatat tatttaaagc tattttatca ccaaaacttt ttgataaatg
    16621 gctaacttca atcatactca ttgcacctcc tttatattct acatttttac ttaacatcta
    16681 tttacttagc tttatcaaat aaacgtctta aaaaaaacaa taacattaag catataaccg
    16741 ttagcaagat tgtttcaata ttattgataa tatgatacat tctcaagcag tataaaataa
    16801 ttatatatat gcaaatgctc attataccta tttttttaaa catactaagc ctccttgcca
    16861 aataataaag ttatataata actaagacac actataccta acataataaa tatccacagc
    16921 attaaaaata ttatcataca aataaaaata tccactggta actgaataaa tgttctaaaa
    16981 ttaacaagca aaaataaaat ctcaaacgat gaaaaaagcc atactatatt ttccaatgat
    17041 gtttgaatat ttttattgta gtaagcataa tatatagcaa aaataatacc caagaacaat
    17101 actattaatt gtgtttctat aacagtgaac tgcccaatag cagataaaaa gctactcctc
    17161 ctgataataa gcaaaaacaa actgaacgaa taaatgtttt cgctctaata ttgttatctt
    17221 tcactttatt atttttttta caaattggac attctccgtt ttccagaaca tatttttctt
    17281 gacttagagc atgatttctc atattataaa cgtaagcgtt atctattagg gtttcattat
    17341 aacatcccag aaatatttta attattaaat tagtcattat ccctcccaaa atagcaggca
    17401 tctctggtgt agtcggccac tttgtcttat cagataaagt gtacttattt atatctttgt
    17461 ttatattccg acaaccaaag caagaaccga tggtagggat atatatatta tcaataataa
    17521 gatagcatcc attaaaccct cctgatatgt aggatatctt atgcgataca gcaaattgat
    17581 tgacaatttt tataatatca atgggcgtat caattgcttt aacgataaaa tctatactcc
    17641 catattccgc aacaattttt tctaattctt ctaatgaaga aactttaata gaaataggta
    17701 ctacctgaac atctgaatta tacttgtgta ttttttcaga aagaacatta atcttctcct
    17761 taccaacatc cgactctgta taaagaattt gcctatttaa atttgatggt tctattatat
    17821 cgtaatcagc gacaataagt ttcctcactc catacatact tagacttaaa gatatataac
    17881 atcctaaggc tcctgctcct aatactaata ctgttttatt ctgtatttta ttatactctt
    17941 cattataaaa taacgaatag taacctttag ttctagaata tctactatca atatctatct
    18001 catccgaaat taaaatttgt tcatttaata gttcaaatgt tagtttactg cctaatactt
    18061 cttctatctc taatagttcc ttgatcgttg ataaattctt gcgaaatttg aggttctata
    18121 gctatttccc gcatactccg accacgtaaa tacattatac cttctttttt ataagcaaaa
    18181 acataactat ttacgtagaa catatttcgt ccttcctatc atatataata tagaaagcag
    18241 tatagaaaca accacccctc ctatactacg aacaataata ttgggtgtca aaaactgtaa
    18301 tagttgactc aaagggaaat aaataataac aaatgctatt aaaagttgaa ctatatattg
    18361 aaaattcaag ttattattgt tagaattcaa gtatcttaaa ataataccac tatcatactg
    18421 aaaaaaagga attgaattaa taaaaatcat acctaagtta atgataaaaa ataagagtcc
    18481 aagcaattta tacgatgtga acaataaaac aagtaaacct gtaagtgata aaatcgaatt
    18541 tgaagcaatt cctgctaaca taattttcaa aaattgtttt ttatttttta ggaattgcac
    18601 cccacttaaa tctacaaaaa aagccaaatt aaacaaaagt agcattattc cacaatttgg
    18661 gatctcaatt tgataattat tagcaattat tgcatgacta aattcatgta tcgttgcaga
    18721 tataataaca acaagcaacc aaaataaaag aatgtttagc gttattggaa agttttggaa
    18781 attagtcaaa atatccgccc tataaatata cataataaaa cattgcaaaa taagagccaa
    18841 tgggaaaata ccaaatagga ttttttcaaa attcttatta aatcttttat agtttaattt
    18901 ttcagataat gttatattaa agtcccaaga tattttaaaa atatttatct tttttcgtga
    18961 tttcatagaa tctataagtc ccattttact aagaacaata taaaatctta aataatattt
    19021 cttccctact aacactaata agtccgatat ggtaaattct tgacctatta gttgctctaa
    19081 ccattttttt cctgtttccc aactaataca tgtttcttac tggatggtat atatagatga
    19141 tactgtccct cataaggagt aggtaatatc ttaatcttat caacaattct cataacaaac
    19201 ctaaccttta ataaataaaa gaggggctaa gtaaaacata ctctagtccc tcagtccgca
    19261 atcaataaaa taatgactaa ttctattaat ctcttgctgc aagactaata cggaaaattc
    19321 aaatgactgt ctaaaatgaa attgaaaaag cttgatgtta gtaaatgaac aaacttcaac
    19381 aaccagcaag agcaaggatt gctaaaccaa atccgatacc tgttgcaagt ccagctgaaa
    19441 aatcactaac tggtactgaa atttcttcaa tttcctcaaa taaaaagtta tcttgcatga
    19501 ttatcactcc ctatcttttt aacaacaggc tactccaatt aagagaacta ccccagttcc
    19561 aagtaaaact tcccccaaaa attcaccatc tgtaggggct acgatttctt caatttcttc
    19621 aaataagaat acttcatctg acatatgtgt taccttcttc atcaaaaatt attttgtaat
    19681 cgattacatt gcagatgtaa cataaagaaa aacaaatgtc aaatattaaa cgtaaaaaca
    19741 tggtcactaa agaactataa gagaaaaggt aaacctagcg acgcgatgaa cgctgatttg
    19801 tttgatttcg attgctctct tcctcttgtt ttttctgttc ttcttcttgt tttttctcag
    19861 cttccttggc ctcttgtttg gctttttcct cagcctccat aattaattta tccgccacag
    19921 tgtaactgta aattccagct tccatgtcga ccacactcgg ttctgacaat tgtggcttaa
    19981 tcttactgta atatggcagt ttcttactca tttcagatag aggaaccaag acttcgtccg
    20041 aatcattcat ggtcaatcga attaaatcgg atgtcacctt gcttggggct aattccacct
    20101 tttggatagc cgccttgagt tctgggctaa tttgagcaag ttctgagaca aaaaccttga
    20161 tttgttcact atcattaaag agaactgata aataagtttc tggtaaactg ttcagactca
    20221 cagaactagt ctcaagctga ccactggaaa gaataggata atgattttca ccagaaatat
    20281 agtaggccac aatatcatat tccttgacct taatagtgaa cttagttgga aattgataga
    20341 caagttgagc tgattcaacc caatagttag acttaatctg cttttcatat tttgccttgt
    20401 ctagcagaag gttaatcgta taatccgaat cctgaatgcc tgaagcctgt cgaatatcat
    20461 cagctgtagt ttgcaccgtt ccctcaacac gaatatcttt catggtcgca taaggactga
    20521 gcaagtaggc agagacaatc aataaaagca gacttggaaa taaaatcgtg aaggctcgca
    20581 agatatggat accaggaatc tttgctttgg ctggtttttc ctttgtagcc tttttagcaa
    20641 gctttttatc ctgttcctcc ttctctttag actctgattc ttctttctct tctttctctt
    20701 tgtcagcctc tgaggatgct actttttctt cagactcttc cttagctgat tctgaatctt
    20761 cctggtctgt ttcactctcc tggtcctgtt tgtcctctga cttctcagat tcttctccca
    20821 tccgagcttg tctttccttt tccttctcct cagctagagc cgcttcttct tcagccttct
    20881 tttttagata ttcttggttt cgtttctgcc attctgataa ctctttcaat tcttcgagga
    20941 tttctttgtc ctcatttttc ttatcttttg acatttactt tccttatgat aaatcttttt
    21001 tcaacaattg ataaaaatct gctagagatt tcaattcctt agaagctttc atcttagctt
    21061 ggtaatcttc cttgtgactt agtaagtgag aaagcttctc ttccaaacta tccaaggtca
    21121 aatcgctttc ttgaaggtct tctgcatagc ctttcttaac aaagtaagct gcattttcaa
    21181 tctggtcacc acgactagct tcacgaccaa gtggcacaat gacatgcaat tttgctatcg
    21241 ccaagagctc aaaaatcgta ttggcaccac cacgtgtcac aacaatatca gccaattcca
    21301 tcaagggttg atagagatcg gtcacatagt caacacgaaa aagattttgg ctcaactcat
    21361 tcaggctaga atctccagtt agattgataa tattgtagcg ctctgttagt tctttcttat
    21421 ggtctgtcac caattggtta aagacacgag cacctgcaga accgccaaca aacaatacag
    21481 tcggcaattt atgattaaag tggctttgaa tatccaccaa ttcatctggt tctggatttt
    21541 tttgatccga aaccttggtc accgctccca catgctcgac cttagccaaa ctcgaagctt
    21601 gttcaaaggt tgaatacatc ttagtcgcaa atttataggc gattttattg gccaagccca
    21661 tagacaggtc agattcgtga ataaagacag gcactcctga cacacgcgca gcgataacag
    21721 gcggtactga gacaaagcct ccctttgaaa aaagggtctg tggacgaagt cgcaacatga
    21781 taaagagcga ttggacgatt ccccagccaa ctttgaagac gtccagcata ttttgccaag
    21841 agaaatagcg acgcaatttc ccagtcgcaa tagaatggaa ggtgacatcc aaacctgact
    21901 taaggatttc ttggtgttcg ataccacgct tgtccccgat atagtggact tcccaaccat
    21961 cttcgatgaa cttgggcatt aacaaaagat tgagggtaac gtgtccaacc gtccccccac
    22021 ctgtaaagac aatttttttc atattttatt cttttaactc cgctactgtg tcgataaaga
    22081 ggtcgccacg tacttcaaag ttagcataca tatcccagct ggcattggca ggactaagaa
    22141 gaaccacatc tccttgagtc gcaagttcat aggccttacg ggtcgcatct gcaatatctg
    22201 tcgcctccac ataagcgaca ccagccttgt ctgctgcccg tttgacacgt tctgcagatt
    22261 gacccaggat gaccatcttc ttgagtccag taatgtctgg caccaattcg tcaaactcat
    22321 tgccacggtc caaaccacct gcaatcaaga cgaccttgct gttgtcaaat cctgataagg
    22381 ctttttgagt agccaagata ttagttgatt tactgtcgtt atagaattta acacccttga
    22441 tgtcatccac aaactggaga cggtgtttga caccaccgaa ggctgaaaga gtttccttga
    22501 tggtttgatt gtccacatca cgaagcttgg ctacagcaat agtcgcaagg gcattttcca
    22561 cattgtggct acctggaaca ccgatttcat tcgctgccat gactacttca ccacggaagt
    22621 agagttgacc atcttccaga taagctccat caaccttttc aagtgttgaa aatggtacaa
    22681 cagtggcttc tgtcttggaa gccaagtctt ttgccaagtc ttgattaaag ttcaagacaa
    22741 ggaaatcagc tgctgtcatc ttgttctgga tattccactt ggctgctaca tattcctcaa
    22801 ataatccatg ataatcgata tgagttggca taaggttagt aataaccgca atctcaggat
    22861 ggaattcttg aacacccatg agttggaaag aagaaagttc cataacaagc gtgttcttgt
    22921 ctgtcgctat ttgagcaacc tgactagctg gatagccgat attccctgat aaaagaccat
    22981 gttgcccagc agcagtcaaa acttccccaa tcatagtcgt tgtggttgtc ttaccgttcg
    23041 atcctgtgat accaataatc ggtgcttctg aaatcaaata agccaattcc acctcagtca
    23101 agactggaat tcccttggcc aaagcctttt caatcatggg attgttgtag gggatacctg
    23161 gatttttcac cataagagca aactcttcat ccaagagttc caaaggatgg ccacctgtaa
    23221 tgaccttgat cccttcttcc agcaaacttt gggcagctgg attgtcctcg aaaggcttcc
    23281 catcatttac tgtcacaatg gcacctagct tgtccaacaa acgagctgca gattcaccag
    23341 acttggccaa acctaaaaca aggactttct tatttttaaa ttgatctatt actttcatgt
    23401 ctcgaactcc atttctactc ctactatttt accattttta tggaaataaa aaagccacaa
    23461 agtgtgtttg tgactctttc ttctagctga atcttgccat atcatctatg tgataaatcg
    23521 gtaactcgaa taacttggtc cacttgttcc caaataagag gattgtgggt cgcaataata
    23581 atagttcgat tcggattttt taaagattct aggatggaaa gtaattcctc agagtttttg
    23641 gggtctaagg aagcggttgg ttcatctgcg aggatcaaag gtggatcctt taaaattatc
    23701 ttcgctaatg caacacgttg tgcttctcct cctgataact caaatatagg ttgcttcaaa
    23761 tccaaataag agaggtttac acggtttaga gcttgtttca tcaaagagat tttctctttt
    23821 tccttcaact ttttaccaac taaacccaga ttgagattct ctttgacggt ttggctttca
    23881 attaagccaa aatcttgaaa taagtatcct aagtaatctc taaagaaaac agaaggcttg
    23941 atgtccttaa gagaagtgcc atcatagatg atttgccctt tgtcatatgg ctctaatcgt
    24001 ccaatcatat tcaagagtgt tgtcttacca cagccacttg taccgattaa ggcataaatt
    24061 ttcccacctt caaaatgaag attcgtatct gaaaatagct gacggcttcc aaatttttta
    24121 gatatattct ttagttcaat catcctattt tcctttcata attgtcatag aaacacgaga
    24181 ttctttctgc gcttgacggt aaagcgtcag aactgcacta gctagaaaga ctaataaagt
    24241 gagcaagcca atcaccaagt ctcgactgct taaaataaaa agactagcac caaatacaaa
    24301 actggcaaat tgactaacca tatactgagc atgtgtttca aaaaatcgta aacctgaaat
    24361 tcgtttaatc aagatatctc ggcggaattg ctcgaaatat agaagattga cagaataaaa
    24421 tagtaacaag gaactagcta tccccacaat agctcctaag attaaagttg ctgtttcagt
    24481 ttgaacttca ttataacgag ttagataaac acttcttcct tctttaagat aggatacttg
    24541 ctcataaatt ccagctttct tcaaaagttc tagcccactc tcatatcctt tgataaagag
    24601 ttgttttcca gcattgatag accaactaga tagggatata aaactatcac ctgtagaagt
    24661 cggcgtgaat accactaaaa tcggatcagt caaatactga gtggatacgg gattctcacc
    24721 gttattataa acaaaccgct tttctcccat tgaaagataa ctaacgtgcg ctttcatctc
    24781 ataatccaaa ggagcacttg cctcctcacc agattttcca taataactca atctttcttc
    24841 aaaaactttc ttaagttctg cttctcgaga gcgcaaatgt tctgggagca agaggataaa
    24901 ctcacctttt tggagatggg ctaacttctg tttggtctca gcatctacca cgaccttttc
    24961 cttgtccaaa taactgggac taacatagag cgtattagca tctggactat aggtatccag
    25021 tgtctctccc tgttcatttt ttccttgtgg attggcaaaa tggagcagat tatcctttac
    25081 ataaagagct tgttcttctt cgattgcttc cttggcaaag gcataccact tgctctgatt
    25141 ttctgtatct tttcctctat cacctaagcc aaaagaaatt tgataatagt ctgctctatc
    25201 ctgccatgct tgttttgaaa tttcaagttc tttcaatcgt tggtaagacg tcaaacctgt
    25261 cttaacagcg tatcctactg taaagacagc aaccaactga cacaataggg ttaaaatcat
    25321 caggcgttta aggggtaatc tccccttaat aacgggaact aatgctttgt aattcaaact
    25381 cattagataa agaagcatta gtaaaattga aatcgccaat aaaaacaaca gatagaaact
    25441 aatcccaaaa ccataggtgg ctaacaagat aggataaaac aaaccttgac taaaaagaac
    25501 gactccccca cctaggaagg aaaggagggc tgatagaagg agccatttga tatcagtaga
    25561 taaagaatgc cccatgatgg ataagagagt ctgaccagaa aagagtttta tacctgctgc
    25621 tctcatttcc ttaatccgag tgataatcac taaagcaaag aaagataagc caaatattgc
    25681 taaactaatt aaaataaggg gatttagtaa tattcgaaaa gcaagaaaat agggcggtat
    25741 ctttcggtca gcacttgctt tataacccaa atctcctaat ttatcggcaa gcttttcttt
    25801 cgtcaaggag cctgacaaaa ggagataact atttagcgga tcactacgtt cacgactttc
    25861 ttggctagct tcttggaatt cttttggtaa agttccctga ccataagttg cataagtaaa
    25921 gtgagtcgtc ccatccttac tcggctctac aattcttcta gctattaaac tctgttctga
    25981 gtttgcaaaa ttctccaatt cctgttcaaa tacctcacgc gtcggttcct gagtatcttt
    26041 tttgacacga agtaaagaaa cggaatcata gcttgcatat aaatattgtg gcgcacgtaa
    26101 gacaataatc caagcaagga agaagctgag aaaaaaagtt gataataata tgaatagttt
    26161 cttcatagta gactccttgt aaacaaaatt ccccctgtaa tttcttacaa ggggaacgat
    26221 ttaaatcaat gaacgattag tcataatcac agtaaaatgc tacttgttct ccccatttag
    26281 tccaaatcca tgcataggag gtttttccag caggagcttc tcctttatca gaatgaccat
    26341 cccatctgct cacgatggat gaataatgat attttttacc atgatagtaa tttgaaaaag
    26401 cctaaccacc tcctgaacct tctccatatg tccatactcc tccatctgga tattgtacag
    26461 cagctgatgc agctcccaat aatgtaaaat ttgaaataag agctagagca agtaatctat
    26521 gttttttcgt tttcatttta ttttttcttt caaaaaaagc acaccttgag caacaatgca
    26581 acaaaataaa tcctcctctc tcttttattg aaaccgcttt cttatgtgat aagaataact
    26641 tttttattat ttgttgtcaa ggaaaaaatc gaatttttta gatattttac tatattacct
    26701 ctgtgaataa tattatatag tagttttatt tcaaaataat atgcaaccag tactaaccaa
    26761 atataaaata gatgccatta acgaatttta ttcaagtttt tcccattcat actatacaag
    26821 taaaagagat ggtgttaact aaaaagcaat tcaaactatt gtaaaattcc tagcaaaaag
    26881 agagccgaaa ctctcttttt tatcttcttt tacttttttt gactggcatg agtgtgatgt
    26941 ctctaacact aaagtaagct aggatcaaca tggctattgc taggaatatt tctgttggta
    27001 attgaaaaat tttcagaaaa gatagaacca ataaaatcaa gagtgccact aaaatacata
    27061 ccatagcgac gatattgaca gtccctttaa tgctttctgg tgtcgcaaat acatagagta
    27121 ggagcagtaa aattcctagg actaaataga ccatctttct ctctttctag ctcttattca
    27181 gctgattttt tcttcttgtt agctttctca cgctctgctt tgttaaggat ttgtttacgc
    27241 aaacggatag actcaggcgt tacttccatg tactcatcgt cgttcaagaa ctcaagagac
    27301 tcttcaagtg tcaagatacg aggcgtcttg ataacagctg tttggtcctt agtagctgaa
    27361 cgaacgttgg tcatttgttt tgccttcgtg atgttaactg tcaagtcatt ttcacgagag
    27421 ttttcaccga tgatcattcc ttcataaacc tcagtacctg ggttgacaaa gatcgtacca
    27481 cgttcttcga tagacatgat tgagtaagtt gtagccttac cagcatcgat agaaacaagg
    27541 gcaccacggt gacgtccacc aatttcccct ggaatcaatg gcaagtattg gtcgaaggta
    27601 tggttcatga taccgtaacc acgagtcatt gataagaact cagttgagta tccaatcaaa
    27661 ccacgcgctg gaacaaggaa gaccaaacga gtttgaccat taccagttga aatcatatcc
    27721 aacatttcac ctttacgttc agaaaggctt tggataacag acccttggta ttcttctgga
    27781 gtgtcgattt gtacacgttc aaatggttca catttaacac cgtcgatttc ttttacgata
    27841 acttctggac gagatacttg aagttcatag ccctcacgac gcattgtttc gataaggatt
    27901 gacaagtgca attctccacg tcctgaaaca gtccatttat ctggtgaatc agttgggtca
    27961 acacgaaggg aaacgtctgt ttgcaattct gcctgcaagc gttcttccac cttacgagaa
    28021 gttacccatt taccttcttt accagcaaat ggtgagttgt tgaccaagaa agtcatttga
    28081 agagttggct catcgatgtg taggattgga agagcttcta ctgcatctgt cggagtgatg
    28141 gtttcaccga caaagatgtc ttccatacct gaaacggcaa tcaagtcacc cgctttggct
    28201 tcttggattt cacgacgttc caaaccaaag aaaccgaaga gttttgtaac acggaagttt
    28261 ttagttgtac cgtcaagttt agaaagggta acttggtccc caaccttaac tgtaccacgg
    28321 aagacacgac cgataccgat acgtccaacg aagtcattgt agtccaaaag tgacacttgg
    28381 aactgcaaag gctcatctga gttatctact ggagctggga tatggtcgat aatcgtgtca
    28441 aagattggtg ccatagtcgc ttcttggtca gctggatcat ctgacaatga agaagttccg
    28501 ttgatcgctg aagcataaac cactgggaaa tcaagctggt cgtcatctgc accaagctcg
    28561 atgaaaagtt ccaagacttc atccactact tctgctggac gagctgatgg cttatcgatt
    28621 ttgttaacaa ccacgattgg gacaaggtct tgttccaagg cttttttcaa tacgaaacga
    28681 gtttgtggca tggttccttc ataggcatct acgaccaaga caacaccgtc aaccattttc
    28741 atgatacgct caacttctcc accaaagtcc gcgtgtcctg gtgtgtccat aatgttgata
    28801 cgagttccgt tgtaagcaac ggcagtattt ttagcaagga tggtaatccc acgctctttt
    28861 tcgatatcgt ttgagtccat agcacgctct gccaattcag tacgtgcatc aagcgtttct
    28921 gattgtttca ataattcgtc aaccagggtt gttttaccgt ggtcaacgtg ggcgataatc
    28981 gcaatgttac ggatatcttc tcttaatttt gtcatgattt cctctataat attcaaaatt
    29041 tattttctaa ctgaacgatt ataccataat ttcaaataaa taacataact caagcaagtg
    29101 taaatgtttt cactccgctt ttcttttcac gtcaagcctt ttcaaagcaa gcgacttatg
    29161 ataagatagg cacagtatgc gtttagataa tttattagcc caagaaaaag ttagccgaaa
    29221 ggccatgaag caagcactcc tcagagggga aattctagtc gatggttgcc cagcccgctc
    29281 cctagctcaa aatatcgata caggactaca agaactcctt tttcaggatc gaatcattca
    29341 aggctatgaa cacacctatc ttatgcttca taaacctgct ggtgtcgtta cagccaacaa
    29401 agacaaggaa cttccgaccg tcatggactt gcttccatct gacatccagt ctgacaagct
    29461 ctatgccgtc ggccgactgg accgagatac aacaggactc cttctcttga ccgataacgg
    29521 tcccttgggc ttccaactcc tccatcccca atatcatgtc gataagactt atcaagttga
    29581 ggttaatgga cttctaacac ctgaccatat ccaagccttt caaaagggaa ttgtcttttt
    29641 agatggtact gtctgtaaac ccgcaaaact agagattcta tctgcaagtc cctccctcag
    29701 tcaagcctct atcaccattt cagaaggaaa atttcatcaa atcaagaaaa tgttcctctc
    29761 ggttggtgtt aaggtgacta gcctcaaaag aatccaattt ggggacttca cattgaaccc
    29821 agatttagca gaaggtaact accgcccttt gaaccaaaaa gagttacaaa tcattaaaaa
    29881 ctatttagag atgagtcgat aaaacaaaaa aagctttaaa actaaagctt ttttctttta
    29941 tttaccgaaa aattaaggcg attgctacaa tccagttaac tacagaaatc acaattccta
    30001 agatattaag aatcttttct attttatact ctaattgtga ctctttttgg tatgaaatag
    30061 ccaagaccaa tcctatgata cccaaaatca ggcctacaat tggaaataac aaaccaagaa
    30121 taatcgacaa gatacccaca aaaagtggat ttttcttctt ttctttcatg ttctaagaac
    30181 tctttaaatt ttatacaaat taattatact ataaaacaat agcttcatcc tatcattcga
    30241 ctaatttgga aataaggtta gctagtcttc actttccctt tccaagaatc caagccataa
    30301 gaaaggatat aaatctcaga aaaaccttgt tttttcaagt aaagagctgc atttgtaact
    30361 cgttgcgcac gttggttctc gtagagaagg acaggtttat ctttacgaag ggctgcaaga
    30421 ctagttttca actgacttga aggaatattg cgtgcacgaa ggatatgttt tctgtggaat
    30481 tctgctgggt cgcgcaaatc aatcaattga cccgtacgaa tcaaggcttc aaactcctca
    30541 ttgtccacaa ttttagccgc acggcgaata cgaagatagt taaagcccat ccacgccaac
    30601 attgctagta taagtgccca caaaatccaa gtaaccatta gttcttttct ccatttttct
    30661 caatataatc caattctacc ttgtgctctc tgcgaagaac tgcttctgcc tctagatagt
    30721 ctaatttatc catcaaccct gcatcgtaaa tccgagatag ttccaacttc atcagttcaa
    30781 tatcatataa gcgttttccc atgtaaacaa taataccaaa tcgtttgagg aattgctgca
    30841 catcatagaa tgttttcata agactcattc tagcaaaatt ttgtgttttt ttcaagaaga
    30901 gactcacaca atgctcctta ttttcctatc ttctttggcg attctaaggc aagtgtggta
    30961 caataaaaac atgagaattc aacaattaca ttatattatc aaaatcgtcg aaactggctc
    31021 tatgaatgag gcagccaagc aactctttat cactcagccc agtctctcca atgcagtgcg
    31081 agatttggaa aatgaaatgg gcattgaaat ctttatccgc aatcccaagg gtattacctt
    31141 gacccgtgat gggatggagt ttctctctta tgcccgtcag gttgtcgagc aaactcagct
    31201 tctggaggaa cgctataaaa atcctgtcgc ccaccgcgaa ctctttagcg tttcgtctca
    31261 acactatgcc tttgtggtca atgcctttgt ctctttgctc aagaaaagcg atatggagaa
    31321 atacgaactc ttccttcgtg aaactcggac ttgggagatt atcgacgacg tcaagaactt
    31381 ccgcagtgag gtcggggtcc tcttcttaaa cagttacaac cgtgatgttt taaccaagat
    31441 gctggatgac aatcacctgc tatcccacca tctcttcaca gcgcaaccgc atatctttgt
    31501 cagcaagacc aaccctctgg caaagaaaga caaggtgaaa ctgtctgatt tggagaattt
    31561 cccttacctc agctatgacc aagggacgca caactccttc tacttttcag aagagattct
    31621 ttctcaagaa caccacaaga aatccattgt ggtcagtgac cgtgccaccc tctttaatct
    31681 cttgattggt ttggatggtt ataccattgc gacagggatt ttgaacagca acctaaacgg
    31741 agacaatatc gtttctatcc cactggatat tgatgacccg attgagctgg tctatatcca
    31801 gcatgagaaa accagcctat ctaagatggg cgaacgcttt atcgactatc tactagaaga
    31861 agttcagttt gatagttgag aaatgataag aaccaatatg taggctagca acaacctgca
    31921 cattggttct ttttacttat aattaaaagt ttcccctgcc aacttatcag ctagcttggg
    31981 aaagagagta taaaacttat gggctaggtt caacaaaatc gggagattga gttctcgttt
    32041 attttttcct ataatcttga caatcttttt agccactgca tctgcctcta agaggaagcg
    32101 gtcaaccgat ttaagataag ttccatctgg gtcagcttgg tcaaaaaatc ctgttcggat
    32161 tggacctgga ttgactgttg tcacatagac tccatagggc ataagttcga gtcgcagagc
    32221 atttgaaaaa ccaatagccg caaacttggt cgctgagtaa agactagact tgccagtagc
    32281 tattagacct gccatgctga cgatgttgat gatatgccct ttgctgcttt ccttcatacg
    32341 agccgcaagg tgacgagaca gattcatcag ggcaaaggta ttgacctcaa acatctggtg
    32401 aatgtcttta tcagcaatct ggtcaaatcc ctcaaaaatc ccgtaaccag cgttgttaat
    32461 caagacatca atcttgccat agcggagata aagatcagtt accagagctt ctagggctga
    32521 atcgtcggta atatcaattt caatcaattc tgcatgggaa taatttccgt agagttgggc
    32581 taatttttcc ttatttctac caagcaagat gagttggtca ttgggcagga gtttgaccat
    32641 ttcttgagct agaccaccgc tagctccggt aatgagaata gtaggcatac ttatcctttc
    32701 tgtgactgct agatttccac ttcttccaag tctttgacca catggacatt ttcaaaaatt
    32761 gtggcagcgt ctttcttgag tttgctaata tcttttgaga ggaaacgggc actgatatgg
    32821 ttgagtagga ggcgtttggc acctgcttct accgctactt gtgcagcttg catattagtt
    32881 gagtgaccat ggttacgagc aattttttca tcacccttgc cataagtgga ctcatgaact
    32941 aggacatctg cattgacagc cagacgcaca ctagcattgg tttttctagt gtctcctaaa
    33001 atagtgataa tcttacctgg acgtggcgct gagatatagt cagccgcctt gatttcagtt
    33061 ccgtcttcca aaacaagatc ctggccgttt ttgattttac caaaaagcgg gccgaacgga
    33121 acaccagcag ccttgagttt ttcagcatcc agcgtccctt ctagatcctt ttgcatgaca
    33181 cgatagccaa cacagaaaat agtatggtcc agctcctctg catacacagt gaatttatcg
    33241 gtctcaagga tttttcctag agaatcttgg tcaaactcat ggaaatgaat gcggtagggc
    33301 agacgagaac ctgacacacg aaggctggtt aagacaaatg acttgattcc ttgaggtccg
    33361 tagatttcca aatctgtctg ctcttcattg gcctgaaagg cacggctaga aaggaaacct
    33421 ggcaaaccaa aaatgtggtc tccatgcaga tgggtaataa agattttgct gatcttacgt
    33481 ggtcgaactg tggtttccag aatgcgattt tgcgtacctt ctccacagtc aaagagccaa
    33541 acttcgttaa tctcatccaa aagtttcagg gcgagacttg aaacgttgcg agctttagag
    33601 ggctgaccag cccccgttcc taaaaattga atatccattc gatactttct aattaatcaa
    33661 tatataacat ggctgtgcgg ttttccgatc ggaaatagcg tttgccagaa aaagcagcag
    33721 cttcttgcaa taaatcctct tggctgtagc ctttgagacg ttttcgacca tcagccaatc
    33781 tttccaaatc agtcaaagct gtgagacttt ctaggctgac aacttcctcg tcctcgacag
    33841 gcttcatgta aatcttacca gactcttcaa agactaattg atgggggaaa atttgcgcaa
    33901 tttcaaagag caagtcatcc gagattttct cctcattttc agagaaaatc cgaccaaggc
    33961 cgtcactatc ataacaaaaa ccaaaggatt taccagacag attaagccga ataaaaggct
    34021 tattttctag ggtgaaactt ggctcagtat tgtaaagatt cagttcctga ctgagttctg
    34081 caaaataatc cgtcgcagcc tgaggactct ttttctgata gagttctgca aagtaggcat
    34141 taacaacact tggcggaggt gtaataagtg ttaactgctc ctgctctgtt ttaccagcta
    34201 gaagctgaac cagatagacc ttgtccagac ttgtataacc tccatacttt agagccaaag
    34261 ctttaatatc agtcataaaa ttcttctaac ctccatttat ttttttcgga aatgtagcct
    34321 gtaatcactt cgctgtcttc ctgataatca cgttcttcca gaattgcaac actctctaaa
    34381 tcatgaatct tgtaggactt tgaaaaaggc actcgcaggg taaatgcttc aaaaatttcc
    34441 ttaatcttat ctagcaataa tgcttgcaag ttttcacgac tgtcctcaga cttggcagaa
    34501 atgagggtat atggcgtttg ggtaggcgtg aaatcctcca ccaaatccgc tttattataa
    34561 agcgtcaagt gaggaatatc ttccatgtcc aggtctttca tgatggagag aaccgttttt
    34621 tcatgctcct cgtggtaagg attgctagca tcgataacat gaaccagaag gtccacatgc
    34681 ttgctttctt ccaaggttga cttgaaactg gacaccaact ctgtcggcaa atcttggata
    34741 aagccaacgg tatctgtcaa agttacttgg agattgcctc ccagatgaat actcttggtt
    34801 gtcgcatcca gagtcgcaaa gagctcatct gcttcatact gggtcttact ggtcaagatg
    34861 ttcatgatag ttgatttccc agcattggta taaccaatca aaccaatctt aaaagtgcta
    34921 gactccaaac gtttttctct gacagtcgca cgatttttct caaccacctt gagctggcgc
    34981 tcgatatccg tgatttgatt gcgaacgcta cgacggttca gctccagctg gctttcacca
    35041 ggaccacggg aaccaattcc ccctgcctga cggctgagca taatcccctg accaaccaag
    35101 cgaggcaaaa ggtatttgag ttgggctagg tggacttgga acttcccttc atggcttcga
    35161 gcccgcatgg caaagatatc caaaatcaac tgcatacggt caatgacctt aacaccgaga
    35221 acttcctcta gattgacatt ctgccttggg gtcagacggt tgttgacgat gacagtagtg
    35281 atttcttctg catccaccat aagcgcaatc tcttccaact taccagagcc gacgaaggtc
    35341 ttggaatcat atttttcacg tttttgtctg tagctatcta caacgactgc ccctgccgtt
    35401 ttcgctaaac tagccaattc ttccatggag aggtcaaaac tgtccatacc ctgcaattcc
    35461 acaccaatca gcaggactcg ctcctctttt ttctccgttt caatcatcta aaaactcctc
    35521 tatctggctt aaaatgcggt cttgtacacc agattctcca atctgataaa aggtgacctg
    35581 catgcgatta cggaaccagg tcagctgacg cttggcaaaa cgacgggtcg cctgtttaag
    35641 actctcacta gcttcctcaa aggtctgctc tccacggaaa taaggaaaga gttccttata
    35701 gccaattcct ttagcagcct gtacattagg ggaatggtca aacagccact tggcctcatc
    35761 caaaagccca gcctcaaaca tcaaatccac tcggtggttg atacgctcat aaagttgact
    35821 acgttcatca tccaagcaga taatcagcgg ttcatacaag gtctcttgat tttccaaatc
    35881 ctgaccaaaa tgggcaattt ctaaggcacg catagcacga cgacgattaa actggggaat
    35941 ctcaaggcct gcttgctcca caaaatgggc taattcctca tctgaatacg gctccaaact
    36001 agctcgataa gctaaaatct cctcatgagg agtctcccca cctaggtggt aaccttctag
    36061 caagctctgg atataaagtc cagtcccacc ggcgataatg gctagcttgc cacggctgtg
    36121 aatatcctca atagtcatct tagcttctga aacaaaatca aaagccgagt aagactcggt
    36181 tatctctcta acatcgatta aatgatgaag aacagctgcc tgctcttctg gactagcctt
    36241 agctgtccca atatcaagtc ctcgatagac ttgttggcta tctccactaa ccacttcgcc
    36301 attaaaacgc tttgcaactt caatagctag agccgtcttt ccaacagcag tcggtccaac
    36361 aatcacaatt atttttgttt tcatcttttt tccttgaaaa attcccattt tttcgttact
    36421 attattataa cacaaaaagg tcagtcagaa aaatgtgacc tcttgaggag gctggctgat
    36481 tgagaatata aaggaggaag actcatggct aaaggattcg ctaaaggtct tgtaacaggt
    36541 gtcgcaggaa ctgtcgctgc cgttgcaggt gcagtatacg catttaaaaa gaaagtaatc
    36601 gaaccagaag agcaaaaagc agctttcatc gaagaaaacc gtaaaaaagc agctcgtcgc
    36661 cgagtatcac gttaagaaac aaaagaagtt gggattattc tcaacttctt ttttctattc
    36721 ttttaaatag ctaggtcaaa cttcaactgt ggcttaacag ggtcataatc caccaactca
    36781 aaatcttctg ctttgatatc aaagaaatta gtcccatcag gaacatttaa aaccaagcgt
    36841 ggttggcagt ttgacggctc ccgacggagc aattcctgag cttgttcaaa ttgattatca
    36901 tagatatgga ggttgttgat gaagtagaag aacttcccaa ccttccagcc aaaatgtttg
    36961 gcaatcatca tctgcaaagc cacatactgc atagcgttga tgtggtgggc caccagcata
    37021 tcattcgagc gctgggtcaa ggtcgcatcc agatagattt ctccatctat acggcggaca
    37081 tcaaacatgg tctgaaaggc gcacgggagc agcccatctg tttcttcgaa agcttggtaa
    37141 tcccagagcg aaataatatt gcggcggttc caaggattgg tttccaactg tttgagaagc
    37201 ttattgataa tgtcgtgttt cttaacaacg gcaccatagc gctcaccaat ggttcccgtg
    37261 tctccaactt cccagtcatt ccagtagtga acattgtact tgtcattaag cacttctaag
    37321 ctatttgact ggtcttggta aatccagaga acttctttga tggcggattt gattgcaatg
    37381 ggacgcaagg ttgtgatagg aaattctcct ttagataagt cgtactcgga aaaggcacca
    37441 gttacatact tggaattagc aacagtccca tccttgtact taggacgagc ctgctctgag
    37501 aaaacacctt cctttagaat gcgttcaata ttctctttaa aaatcgtatc tgcttttgtc
    37561 atttcgtttc acctcattca ttgtcctaac tagtatagca taaaaaataa aagaggaaca
    37621 ttactaactc taggttagca ttttcctctc tcattatctt attgcaatac aagtgatgct
    37681 gctccgataa ctccagcgtc atttcctaga gttgcaagag ctaatttagt agatgtgcgt
    37741 acttgtggga aactattttc atcgtaaact ttttgaacac cttgtagaag gaattctccc
    37801 gcagctgaca caccaccacc gatgacgatt gttgatgggt ttaggattga accaatgtta
    37861 gcacaagcga ttcccaagta acgtgagaag ttacggtaaa caatcaaagc aaggtcgtct
    37921 ccttcttttg cgagatcaaa gacagtctta gcagttactt cttctccgtt atcaatcaag
    37981 cgtttcaagg ctgcatcgcc ttcgtattca tcggcatagc gacgagtcaa gttgacaatc
    38041 cctgttgctg aagcaactgt ctcaaggcag ccttttttac cacaagtaca tgagattggt
    38101 tggtcaaagt caacagtgat atgaccaagt tcacctgctg caccagcaac accatgaagc
    38161 aatttgcctt ctgcgacaat accaccacca acaccagtac cgagtgtcat aaagacaacg
    38221 tctggttggt tatctccagc acccatccag cgctcaccaa gagctgctac gttggcatca
    38281 ttatcgatga aaaatggaat gcccaaagct ttttcaatct tttgtttgat tggttgaagg
    38341 gttttccagt tcaagttgta ggcaccgata acagtccctt tgtcacggtc aaccacacct
    38401 ggtgatccca ttccaatgcc ttggaagtcc gctgctgcca atccaagcaa gtccaaacga
    38461 tgttgaatag actcaatcat atcatcaacg atatgacttc cctcatccaa aatgttggtc
    38521 ttgattgacc attttccttg gatttctcct actgttgtta agattgcaaa tttgatagaa
    38581 gttccaccaa ggtcaatccc aataatcttt tgactcatca tattctcctt tttcattgtg
    38641 tagtaattga aaatgcttac agtactagta tatcaaaatc cattcactta tgcaaaggtt
    38701 tgcgtaaatg aattataagg aattttttcg cctaccagta tctgttaatc atctaaatga
    38761 tcaatggcat attgagctgc atcatttgaa aatttatcaa aatcagaagt taattgtcta
    38821 tacatacgtt tttttgacat gtggaataac gaattataac tttttgcctt tcctaaagca
    38881 gcagaatatt cactattgct atcattacta gaagaaactg tacttgcttg accttccttc
    38941 caaactccgt cagcgccaac ataataacgt ccaccatcaa cccattcatt gacagccatt
    39001 ttaccatccg attttagata gtaatttcct tgccatgtac tgtaagcata agaaccatct
    39061 gatgtcaaat aataccaagc ttgataggtg gcatcataaa cccattcacc tttagccatt
    39121 ttaccatctg atttcaaata gtagtttcct tgccatgcat tgcgagcata tgaaccatct
    39181 gatttcaagt aataccatgc ttggtaagaa gaatcataaa cccactcacc ttgtgccatt
    39241 ttaccgtttg atttaaggta ataagctcct tgccatgcat tttttgcata agaaccatct
    39301 gatgtcaaat aataccaagc ttgataagaa gagtcataaa tccattcact ctgtgccatt
    39361 ttaccatcag ctttcaggta atagcttccc tgccatgcat ttttcactag atttccattt
    39421 ccatcaaagt agtaccaagc gccgtcctgc ttaacccaac cacttgttgt tgctgaactt
    39481 gtgttgattt gaatagccgt tgactgtttt gctttaaaag cacccttagg agcatttttc
    39541 aattcgcaag ccacaccatc atgatcacgg tctaacttgg cagaataacc aggttctccc
    39601 tcgtgaatat ccgaatagcc attcgcccaa gcttccttac agctcgaaaa atggatgttt
    39661 tcttccgcca aaactggttg tgaaaacaag gctaaaattg gcaacgtcac cagactcatt
    39721 tttaaaaata gacgtttatt catttctttc tcccataatt atgatatcga tttcaatatt
    39781 attttatcaa acttatttca gcaattcaag gaaacttctg gtcttttcta caaactcctt
    39841 tggttttgcc ttattcaaga catgagggcc atcaggaatg atctgaaact gcgaatctgt
    39901 taacagtcta tggagagctt tcatagaact aagattcggt ttatctttgc tgccacaaat
    39961 tagtaaggtt ggataggagc aagtccctgc tatatccgtt aaatcaagtg tcttcaattc
    40021 ctcagaaact ccgaccataa gagtcttgtc tgctccctgt ttttcaaata ctcttttggg
    40081 aagtagttta aaaatcagca actgaagata aaataggata ttccctgcta atttaagcgg
    40141 gcatcctgac agaatcaaag ctcgaagatt tggtaaatcg taactggaaa gttctagtgt
    40201 cagggcagca cctaaggaca atccaatcaa aacaaaaggt tctgtctctt gagctaggtg
    40261 ctgataaact cgctctttag cttgttgata gttactaact ccagaaggaa ataactcgat
    40321 agcctcagaa ggataatctg tcagtagatt ccgaacttct ttccaagact ctgctgactg
    40381 ccctaaccca tgcaaaaata tcaatttcat ctagttctcc tcaaggctta gttcatacaa
    40441 gcctctcact gcattacagc cgtaaatagc ttctgcttgg gttaaatctg ccaaggtcaa
    40501 gactttctct tctacctgtc ctgtttctag caaatgctga cggtaaattc ctggcaagat
    40561 tccaagtcgg ataggcggtg tgtagagttt tccagcgatt ttcagaacca aatttcctat
    40621 agaggtttca agcagttctc ctgacttatt gtggtaaatc ttctcttgtt ctcctaggct
    40681 caaatgcggt cggtgagtgg ttttaaagta ggtaaaggat tgattcaaag cagcttcctg
    40741 aaggcagact tgggcctgac aaaagcttgt actgagaggg gttaatactt gacgattgac
    40801 ttctatctct ccagatttgc taaggctgat tcgcaagcgg taatcttgat tagcttcaca
    40861 atcctgacac tcttcctcaa tcttgtgtcc caagtcttct gcatcaaaag gaaaggcaaa
    40921 ataacgacta gcttttctca gtctttccag atgttgatct tcaaacagca ggttcttctg
    40981 gctgatttcc cctgtcgtaa tcagttggaa gcgagcttgt ttacgataaa gaactgctgc
    41041 cttttgatga acctctcggt attcagattc ccatgtgcta tcccaagtaa tccctccgcc
    41101 aactccataa atggcttgac ctttgtgaag ttgaatggta cgaatggcca cattaaaaat
    41161 ccgtcgtcca tttggaagca agagaccaat cgttccacag tagactccac gcggttgagg
    41221 ctccaagttc ttgataatct ccattgtcgc aattttcggt gcacccgtta tggaaccaca
    41281 aggaaagagt gagcggaaga tttcaacaag gtccacatcc tctcgcaact gactcttgat
    41341 ggtcgaagtc atctgccaaa cagttgaata ctgctctacc tggcacagac gctccacgtg
    41401 ctcgctccca acttcagaaa tacggttcat atcattgcgc aagaggtcca caatcatcat
    41461 attttcagag cgatttttgg gatcctgttc caaccaactg gcctgttcaa gatcttcttg
    41521 gtcagttacc ccacgctgag tcgtcccctt cattggtcgt gttgtcaact cgcgatcatt
    41581 ttgctcaaaa aagagctctg ggctcatgga aatcactgcc atctcgtcat gttccacata
    41641 ggcattgtag cccgcctcct gctctaccac catacgattg tagatggcaa aaggattggc
    41701 acttaacttt tgcttgagtt ggacggtgta gttgacctga taggtgtctc cctgcctcaa
    41761 gtgatggtgt atctgggcaa tggccttttc atagtctgct gcagacgtta cttcctgcca
    41821 atttgagggc aaatcaatat cctcataagt cagaggaata ggggaagttt ctacgctatc
    41881 atgaacagta aaataaagca ggtactctcc cagtagggga tccttgtgaa ctgctaattt
    41941 ttcctcaaaa gcaggtgcag cctcgtagct gacatacccc accacataat aaccttgctc
    42001 ttggtagctt tccacttgtg ccagcaaatc tgccacttct tctacatttc tcgttttcaa
    42061 ctctttaata ggctgggtaa aggtatatct ctcccctaaa gtcctaaaat caatcactgt
    42121 ttttctatgc ataccttaag tatagcataa aataagaaaa ccctcatccg caaagcagat
    42181 gagagatttc gattatctaa agatagaagt tttaaagcta tctgtttgtt gaagaagttt
    42241 cttataaaca gcttctttta gttttactgt attagtcata gatactgttt tgtgaccgtt
    42301 tgcttcttgt ttaagagttt cagcatcttt tttaacagct tctttaaata gtgtaagtaa
    42361 atcatcgtat gatgaaacgg aagaaccatt tacttcgaat gttgttaatc ctttcgttgc
    42421 tttatcttta acttctttga aataagcttt tttaaattct tcaatagtgt tgaatgtatt
    42481 attagatatt ttcttgataa tatattcatc acttagaact gactcgccat cttttgtaga
    42541 ttgttgttta tatttattcg aagtatagcc taggaatccg ttaaggtatc cgtagtaacc
    42601 ccataatcta aaggcgttat gtttgaatga aacagctcca ggagcacctt tactagtatt
    42661 acctccgtag ataccggctg tcatttcaac ccccacataa ggtgattgat cgtattggct
    42721 aacgacttca ggtttataaa cacggtttcc aatttgtcta ttagtcatta actgttgatc
    42781 tattaaacta tcaattgatg taatatttaa gttatctttt tcttcagttg ttagatttcg
    42841 aatttcgtcc cactgattta attggctggc atctcggaat ttcttatcta ttttcttgaa
    42901 ccatgctcca tttaactctt tattattttg attaataaca gcatctgcct ctaaatgatc
    42961 gacaagcatt aaagcatcat tgtaaccacg catatattta tcgatatcat cacgtgttgt
    43021 aagagattta ggatctgtat cgtaccattg attaccatca ttaggttttt tgaatacggt
    43081 attcagacct aatgaaccat attcgttaaa tccacttcct gggactggta gttgtaacat
    43141 accttgagca aatgcttcag catcagtacc ttcacgacgt ccaaaaccac ccaaatagat
    43201 tttacgatcg tttatatgtg ttgtttcatg agtatataca gaaataccat aatccccaat
    43261 catatttaga gcaacataac ttacatcaga acgaggatcc attggattat cataaagtgc
    43321 agcatatgct cctgttccat tataaccata atatttttct ataggtccaa agaattctct
    43381 aagaggagta tatacattgt cagtattata tcgaccgtat ttttcaaccc agccacctgg
    43441 cgcattataa ccttcccaga taggaatcac agtatctctt agtagatatt gtttaacatt
    43501 atctggaact agacgatacc aaaaatcata gtagtttctg tacccatcag cagcataatc
    43561 aacagatgct ttaatgtctt ctaatgattt ttttcctaat ttctcagcac taccaattgc
    43621 aattgcgttg tagttagagg caataaacat gtgtgattta gttatattca ataatggtaa
    43681 aatcattttt ctgtgctgag ctacgtttaa gttagcatat gctctatatt tagcattttt
    43741 aatttcttcg acctcagatg cgcgttctgc gatgtagaca tggtcttttg tagcatcaat
    43801 aaaccaatca ttcatattat ctatatttgt gaataattgt ctattataat ttaagaatac
    43861 atctaaatta cctgatttag tatatttagc taatacttca ccgaatgcgt cgaatgtacg
    43921 tgaaccttta atgttgttct ctttagagcc gatttcaatt aatctgtcta atacgctaac
    43981 tttttcacca tagaagtctg gtttgaataa cattaattct ttaatattaa catcaccgaa
    44041 tttaacaccg tagtaacggt ttaagtatgt taaacctaat aatagggcag ctttgttttt
    44101 ctcgacttta tcacgaagca tttgacgagc agctggagaa tcatttaact ggtgttcttc
    44161 attttgaact aattttgtga ttaggtttgt taagttcttt ttaacggctg tgaagctttc
    44221 ttctaaatat aaatctttga ttgcattaac tctatagtca cctaatcgat ttaggtgttg
    44281 atacattgtt tgagattgaa gatctactgg ttctaaaata gattttatgt cattaacaag
    44341 agtagtgtta tctttttgca cgatattggg tgtatattta attcctaggt cagttatagt
    44401 atattctttt acattactta aaccttcact gctagaagat aagttaaagt aatcttttgt
    44461 accgtctgca tagtgaacaa taattttatt agcttcatct aggtttgtga taaactcatt
    44521 gttgttcatc gctgtaacag aaaggacttc tttagtattt agagggtgtt ctttatttaa
    44581 tttattacct tggtatacaa tataatcttt attgtagaat ggtattaatt tttcaaggtt
    44641 tttataggct tgattatatt cagcgttgta atcttgaata ctagaataag ctttttcttc
    44701 attaagtttt gcaagaggag atagctcact ttctaattta tcagcagtaa tattgaaagt
    44761 agcaacttta gcatcagctt gttctttagt taattgtttt attttttgca gattggtaaa
    44821 attattagct ccactgctag cgccgttgac tctataaata tcagataaga attggcgtgc
    44881 atctccgtca ttaatttcgt ttgaaccata tacttcttca cctttaatta ctttagcata
    44941 ggtaacaata tcttttataa ctccccaagg ccaagtttta gctacaacac caccaacaaa
    45001 acgagtattt ttaacatcta aagttccttt agcaaccgaa ttggtaactt ttgacttagt
    45061 tccatactga tagctattta acatatatgt aaccaaagga actagcatac ttgcgcttgc
    45121 gttagcggca gtaatgttag catcaacata agctttatta acaaatccca tgtagttcga
    45181 accagcaatt cctccgactg tagaattatt accaacagaa ttgatattac ctataaatgc
    45241 tacgttttct agagcagcat tttctttgat attgtttaca aatccagcaa cgttatttct
    45301 ggctgttatc gttccagttg ctttgatgtt ttctatacgt gtggttccgt tgatttcatt
    45361 cgcaattgtc gcgatattat cttgattaga cacattaata tcaatatttt caaaatttat
    45421 atttttaaca gttccagctt taatcttgtc aaataatgga tgttccaatt cagtaatagc
    45481 aaattgtttt ccttcagaac ttaaaagttt tcctgtgaat tctttagtga tatatgattt
    45541 tccattagga acaacatttc tagcgctcat tgattgtccc agacgatatt cttttgaagg
    45601 atcgttttga atagcttcca ctaattcttt gaaattataa tatacattat cttcgtggac
    45661 tttaggtttt tcaatatagt gaacgtattc ttcttcaaat ttattatcag cagttctaga
    45721 gactaaattg tctgcgattg ctgtaacttt atatacatgt gttccgttaa ccgtagtttc
    45781 ttctatattt ttaacagcta gtaatgtagt tttctgatta tttgaagtta tttttaaata
    45841 ataattgctc ttatcatcag gaatagttgt tatcagtgat tcattagttt cttttccatt
    45901 ttcgtatttg attaaatctg tacgtttaat atttttaagc tcaacttttt taagatctaa
    45961 ttgaatattt tgattttcta gagtttcagt ttcttcaccg ttacctctgt cgtaaatcat
    46021 agttgtagat agggtgtatt ctttgtagta ctctaggttc ttaaatgcag cgcttatagt
    46081 ttctgttgtt accttgtcat ctgtaagaac tacagtatta ataacttctt ctcctttttt
    46141 caactcagct gtgattgatt tgatttttgt tttgttttga ttttctagag tatacttagc
    46201 aacagcttca cgttccaata ttttcttatc ggtactagtc aatgttaata ttggcttttc
    46261 agataattca accaattttt caatagttgc agttaatttt tcaacagctt cgttaacttc
    46321 actttgttta gcatctgtat tagctgcaac tttttcagcc tttgtaactt cagtttggag
    46381 gttttgccaa cttctatcac tgtaatgttc ttttaccttt gtttttgcat ctgcaatcgt
    46441 attgtttaat tcagttttat caacgtttag agcgtcaata gccgttttaa gtttatttgt
    46501 ctcgctattt acctcaggct gttttacagg ctctgaagca tagacacctt ttgcagtttc
    46561 taaaacaggt ccaagagcat tgtaacttgc tgtagaataa tcagtaggag aaactgaact
    46621 agctttatca atttgattat ttaactcact tttatcaact ggttctttag taccaatacc
    46681 ctttatttta tcttctggtt tcggtgtttc ctctacagcc ttctcttctt caggaacttc
    46741 tggttgcttt tctggctcaa ctggtgccgt tggtgcctgt tcgtcttctc ttggcgcgac
    46801 tggttcacct gcttgttcaa cttttggttc ctctgttggt tctgtttgtt tttctacagc
    46861 aggcgtttca acttttggtt gttcaataga ttgattaaca gtctcctctt ttggttctac
    46921 agtttcttca gccttggtat ctggagttga ctcttcttgt ttcggtgttt cctctacagc
    46981 cttctcttct tcaggagctt ctggttgatt ttctggctcg actggtgcct gttcgtcttt
    47041 tcttggcgcg actggttcac ctgcttgttc aacttttgat tcctcagctg gtttgtctga
    47101 tggttgactt tctggcttaa ctgctacttt ttcctctggt tttgactcaa cttctccacc
    47161 tacttcttca actggagctg gttctgctga atcttctttc ccctcttcta ctttaggaag
    47221 ggtgtcgtca gtaggtttta cctccgattt tggttcttcc tttggacttt cttctgtttt
    47281 aggtgcttct tcttttggag cttcctctgt ctctactact tggttttctg tcctagcttg
    47341 ctcctgattt gttgttgatt gaggagtctc aacttcgact acagtcacct ctccaggttt
    47401 tgctgaggtt tcttctaaaa cagtgtccaa gccaagcgtt ttgaggatgt cacctgatag
    47461 ataaccaaca tagcgatagc cctccatttc aacaacaccc tctcgactag ccagtgctag
    47521 ggtcgcaact gggtttacag cccctgcact aggaagaact accaatccca tag
//
LOCUS       DBMVGT010000009        44868 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.009, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000009 DBMVGT010000000
VERSION     DBMVGT010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 44868)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44868)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44868
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.009"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(460..2187)
                     /gene="ezrA"
                     /locus_tag="AC0DU4_000532"
     CDS             complement(460..2187)
                     /gene="ezrA"
                     /locus_tag="AC0DU4_000532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation ring formation regulator EzrA"
                     /protein_id="HIN4236536.1"
                     /translation="MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEE
                     LYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAESYNHSF
                     RFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRV
                     AENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIV
                     DRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENI
                     RQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLG
                     EDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDL
                     QTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTF
                     LKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQ
                     LLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSY
                     EKTRETIRF"
     gene            complement(2269..4215)
                     /gene="gyrB"
                     /locus_tag="AC0DU4_000533"
     CDS             complement(2269..4215)
                     /gene="gyrB"
                     /locus_tag="AC0DU4_000533"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005694 - chromosome [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HIN4236537.1"
                     /translation="MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLH
                     HLVWEIVDNSIDEALAGFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVF
                     TVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVAD
                     LEVVGDTDRTGTTVHFTPDPEIFTETTIFDFDKLNKRIQELAFLNRGLQISITDKRQG
                     LEQTKHYHYEGGIASYVEYINENKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVM
                     SFANNIHTHEGGTHEQGFRTALTRVINDYARKNKLLKDNEDNLTGEDVREGLTAVISV
                     KHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFSDFLMENPQIAKRIVEKGILAAKARV
                     AAKRAREVTRKKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQ
                     AILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDAD
                     VDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPIYGVKVGSEIKEYIQPGADQEIKLQ
                     EALARYSEGRTKPTIQRYKGLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDM
                     LMGDRVEPRREFIEENAVYSTLDV"
     gene            complement(4230..4793)
                     /locus_tag="AC0DU4_000534"
                     /pseudo
     CDS             complement(4230..4793)
                     /locus_tag="AC0DU4_000534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398926.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
     gene            complement(4878..5432)
                     /locus_tag="AC0DU4_000535"
     CDS             complement(4878..5432)
                     /locus_tag="AC0DU4_000535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DJ-1 family glyoxalase III"
                     /protein_id="HIN4236538.1"
                     /translation="MVKVAVMLAQGFEEIEALTVVDVLRRANITCDMVGFEEQVTGSH
                     AIQVRADHVFDGNLSDYDMIVLPGGMPGSAHLRDNQTLIQELQSFEQEGKKLAAICAA
                     PIALNQAEILKNKRYTCYDGVQEQILDGHYVKETVVVDGQLTTSRGPSTALAFAYELV
                     EQLGGDAESLRTGMLYRDVFGKNQ"
     gene            complement(5443..6666)
                     /locus_tag="AC0DU4_000536"
     CDS             complement(5443..6666)
                     /locus_tag="AC0DU4_000536"
                     /EC_number="2.4.99.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008955 - peptidoglycan
                     glycosyltransferase activity [Evidence IEA];
                     GO_function: GO:0015648 - lipid-linked peptidoglycan
                     transporter activity [Evidence IEA];
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA];
                     GO_process: GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HIN4236539.1"
                     /translation="MKRSLDSRVDYSLLLPVFFLLVIGVVAIYIAVSHDYPNNILPIL
                     GQQVAWIALGLVIGFVVMLFNTEFLWKVTPFLYILGLGLMILPIVFYNPRLVASTGAK
                     NWVSINGITLFQPSEFMKISYILMLARVIVQFTKKHKEWRRTVPLDFLLIFWMILFTI
                     PVLVLLALQSDLGTALVFVAIFSGIVLLSGVSWKIIIPVFVTAVTGVAGFLAIFISKD
                     GRAFLHQIGMPTYQINRILAWLNPFEFAQTTTYQQAQGQIAIGSGGLFGQGFNASNLL
                     IPVRESDMIFTVIAEDFGFIGSVLVIALYLMLIYRMLKITLKSNNQFYTYISTGLIMM
                     LLFHIFENIGAVTGLLPLTGIPLPFISQGGSAIISNLIGVGLLLSMSYQTNLAEEKSG
                     KVPFKRKKVVLKQIK"
     gene            complement(6703..9153)
                     /locus_tag="AC0DU4_000537"
     CDS             complement(6703..9153)
                     /locus_tag="AC0DU4_000537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0004386 - helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006139 - nucleobase-containing compound
                     metabolic process [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional DnaQ family
                     exonuclease/ATP-dependent helicase"
                     /protein_id="HIN4236540.1"
                     /translation="MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTD
                     VNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIFDLVEDGIFVAHNVQFDANLLAE
                     NLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE
                     LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYF
                     KKTAASLEPRKLSQDFSKNISLLNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGK
                     TYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHTDIHSLKGPQNYLKL
                     DAFYHSLQENDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLS
                     SQSLFVTEDFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLA
                     LENLLQETYDIQSIIDLIDKALVGEENRVQQRILESIRFECLYLIEQFQSGKSRKNIL
                     DSLDNLHQYFSELEVEGFDELVRYFTAEGDYWLEVTETSQKKIQISSTKSCRTLLSSL
                     LPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTET
                     SLEVYAREVAALLVEIQAFQQPILVLFTAKDMLLAVSDLLTVSHLAQYKNGDVHQLKK
                     RFEKGEQQILLGAASFWEGVDFSSHPFVIQVVPRLPFQNPQEPLTKKINQELNQEGKN
                     AFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIVGKRYGKQIVVSLAEEATVK
                     TISRSEVDEAIDRFFNEL"
     gene            complement(9353..10282)
                     /locus_tag="AC0DU4_000538"
     CDS             complement(9353..10282)
                     /locus_tag="AC0DU4_000538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006154193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase U32 family protein"
                     /protein_id="HIN4236541.1"
                     /translation="MEKIVITATAESIEQVEQLLEAGVDRIYVGEKDFGLRLPTTFSY
                     DQLREIAKLVHDAGKELIVAVNALMHQDMMDRIKPFLDFLEEIKTDYITIGDAGVFYV
                     VNRDGYSFKTIYDASTMVTSSRQINFWGQKAGASEAVLAREIPSAELFKMPEILEIPA
                     EVLVYGASVIHHSKRPLLQNYYNFTHIDDEKTHKRDLFLAEPSDPESHYSIFEDNHGT
                     HIFANNDLDLMIKLTELVEHGFTRWKLEGLYTPGQNFVEIAKLFIQARNLIQEGNFSH
                     DQAFLLDEEVRKLHPKNRFLDTGFYDYDPDMVR"
     gene            10422..10709
                     /locus_tag="AC0DU4_000539"
     CDS             10422..10709
                     /locus_tag="AC0DU4_000539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3270 domain-containing protein"
                     /protein_id="HIN4236542.1"
                     /translation="MPVRKLQSYEVDYQEELNQQLPHYQAYTPEAQSDANLKEILFFI
                     NIAVFCICIAIFSFIFLALKLSTALAFAAAIGFSLLVLKVQRSIIKRKRRR"
     gene            complement(10743..12077)
                     /gene="ciaH"
                     /locus_tag="AC0DU4_000540"
     CDS             complement(10743..12077)
                     /gene="ciaH"
                     /locus_tag="AC0DU4_000540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000491790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     CiaH"
                     /protein_id="HIN4236543.1"
                     /translation="MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLY
                     TSVDDKLHGLSENPQAVIQLAINRATEEIKDLENARADASKVEIKPNVSSNTEVILFD
                     KDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
                     IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQ
                     SFVENASHELRTPLAVLQNRLETLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLN
                     LARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRIHRTIVTDQLLLKQL
                     MTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKA
                     RTRQKGGFGLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK"
     gene            complement(12067..12741)
                     /gene="ciaR"
                     /locus_tag="AC0DU4_000541"
     CDS             complement(12067..12741)
                     /gene="ciaR"
                     /locus_tag="AC0DU4_000541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CiaR"
                     /protein_id="HIN4236544.1"
                     /translation="MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGV
                     YDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESLDDKGHGFELGADDYLTKP
                     FYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
                     FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGY
                     LLKDVQ"
     gene            complement(12850..15396)
                     /locus_tag="AC0DU4_000542"
     CDS             complement(12850..15396)
                     /locus_tag="AC0DU4_000542"
                     /EC_number="3.4.11.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001149089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008237 - metallopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HIN4236545.1"
                     /translation="MQAVEHFIKQFVPEHYDLFLDLSRETKTFSGKVTITGQAQSDRI
                     SLHQKDLEITSVEVAGQARPFTVDHDNEALHIELAEAGQVELVLAFSGKITDNMTGIY
                     PSYYTVDGVKKEVLSTQFESHFAREAFPCVDEPEAKATFDLSLRFDQAEGELALSNMP
                     EIDVENRKETGIWKFETTPRMSSYLLAFVAGDLQGVTAKTKNGTLVGVYSTKAHPLSN
                     LDFSLDIAVRSIEFYEDYYGVKYPIPQSLHIALPDFSAGAMENWGLVTYREVYLVVDE
                     NSTFASRQQVALVVAHELAHQWFGNLVTMKWWDDLWLNESFANMMEYVCVDTIEPSWN
                     IFEDFQTGGVPLALERDATDGVQSVHVEVKHPDEINTLFDGAIVYAKGSRLMHMLRRW
                     LGDADFAKGLHAYFEKHQYSNTIGSDLWDALGQASGRDVAAFMDSWLEQPGYPVLTVK
                     VENDVLKISQKQFFIGENEDKNRLWVVPLNSNWKGLPDTLETESIEIPGYAALLAENE
                     GALRLNTENTAHYITDYQGDLLEAVLAELETLDNTSKLQIVQERRLLAEAGHISYADL
                     LPVLDKLAKEESYLVVSAVSQVISALERFIDEGTDAETAFKGLVAKLARHNYDRLGFE
                     AKDGESDEDELVRQLAVSMMIRSNDAEASQVASQIFATHKENLAGLPAAIRSQVLINE
                     MKHHETKDLLALYLDTYTHATDAVFKRQLAAALAYSTDADNIQNLITSWKDKFVVKPQ
                     DLSAWYYQFLAHQATQKTAWSWARENWAWIKAALGGDMSFDSFVILPAHVFKTQQRLA
                     EYKEFFEPQLSDLALSRNIGMGIKEIAARVDLISREKAAVEAVVLQYGNA"
     gene            complement(15519..15959)
                     /locus_tag="AC0DU4_000543"
     CDS             complement(15519..15959)
                     /locus_tag="AC0DU4_000543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512572.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ASCH domain-containing protein"
                     /protein_id="HIN4236546.1"
                     /translation="MIPQEMWNKYKQINPLIGDEIDAWAFGVEPDLLADLVFKGEKTA
                     TASAYDLYVLEDEPLPQVGTFDVILDSQNQSVCIVEITKVSVELFNQVSAQHAFKEGE
                     GDKSLAYWRQVHEDFFTDCLGEVGLTFTPESKVVLEEFRKVYPL"
     gene            complement(15934..16803)
                     /locus_tag="AC0DU4_000544"
     CDS             complement(15934..16803)
                     /locus_tag="AC0DU4_000544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016772 - transferase activity,
                     transferring phosphorus-containing groups [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="putative PEP-binding protein"
                     /protein_id="HIN4236547.1"
                     /translation="MRNQLALSGEKILEKIYPQLFHHVGMIRGEYLLRELNQNIILAS
                     CQQFVKDYLETICSLYSDEEVWYRFSELTNTEANCLVGTREFFDEGHPLFGYRGTRRL
                     LACLDEFQAEAHVVTEVYQTNPNLSLIFPFVNDADQLKQAITVLRQYGFTGKVGTMIE
                     LPSAYFDLDRILETGISKIVVGMNDLTSFVFATMRNSQWHDMESPIMLDMLRDMQDKA
                     RKNKIDFAVAGYLNTSFIQKMNQLGIKCIIHYSSIPEIFDLEIDHPDHLKHIKEESKK
                     LQRSTHDTARNVE"
     gene            complement(16781..17281)
                     /locus_tag="AC0DU4_000545"
     CDS             complement(16781..17281)
                     /locus_tag="AC0DU4_000545"
                     /EC_number="3.6.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HIN4236548.1"
                     /translation="MEIKKHFGVYAVCLENGKLLCIEKTRGPYQHRYDLPGGSQQLGE
                     GLTETLTREVMEETGFTVRSYSNPRIYDVFVREELTNFMVHHVMALYDVEMNESAPQV
                     TTSEAVSDGANDSLGYIWMDIQEITEENASPLVLKVKSELLGFPELDKTSYMNWKVND
                     EKSTCP"
     gene            complement(17292..17990)
                     /locus_tag="AC0DU4_000546"
     CDS             complement(17292..17990)
                     /locus_tag="AC0DU4_000546"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="HIN4236549.1"
                     /translation="MTKRVLITGVSSGIGLAQARLFLEKGYQVYGVDQGEKPLLEGDF
                     HFLQRDLTLDLEPIFDWCPQVDVLCNTAGVLDAYKPLLEQTAQEIQEIFEINYMTPVE
                     LTRYYLTQMLENKKGIIINMCSIASSLAGGGGHAYTSSKHALAGFTKQLALDYAEAGI
                     QVFGIAPGAVKTAMTAADFEPGGLADWVASETPIKRWIEPEEIAELSLFLASGKASAM
                     QGQILTIDGGWSLK"
     gene            complement(17983..18219)
                     /locus_tag="AC0DU4_000547"
     CDS             complement(17983..18219)
                     /locus_tag="AC0DU4_000547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018367459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2829 domain-containing protein"
                     /protein_id="HIN4236550.1"
                     /translation="MTFEEILPGLKAKKKYVRTGWGGAENYVQLFDTIEQNGLALEVT
                     PYFLINVSGEGEGFSMWSPTACDVLATDWVEVHD"
     gene            complement(18319..19245)
                     /locus_tag="AC0DU4_000548"
     CDS             complement(18319..19245)
                     /locus_tag="AC0DU4_000548"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HIN4236551.1"
                     /translation="MRYITLGQDDKELSEIVLGMMRIKDKSVKEVEELVETALSVGIN
                     AFDLADIYGRGRCEELLGLVLKNRPDLREKMWIQSKCGIRIEEFTYFDFSKDYIIKSV
                     DGILQRLKIDHLDSLLLHRPDALMESDQVAEAFDLLYKQGKVRDFGVSNQNPMMMELL
                     KKDVKQPLAVNQLQLSAAFTPGFESAFHVNMEDSQAAMRDGSIFEYCKLHDVVIQAWS
                     VLQFGYFKGNFVGNEKFQALNQVLDRLAIKYGVTSSTIAISWILRYPAKMQAVVGTTN
                     PKHLREVSQAANFSLTRKEWYEIYLAAGNNLP"
     gene            complement(19320..20135)
                     /locus_tag="AC0DU4_000549"
     CDS             complement(19320..20135)
                     /locus_tag="AC0DU4_000549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236552.1"
                     /translation="MKKMKYYEETSALLHEFSEENQKYFEELWESFNLAGFLYDEDYL
                     REQIYLMMLDFSEAERDGMSAEDYLGKNPKKIMKEILKGAPRSSIKESLLTPILVLAV
                     LRYYQLLSDFSKGPLLTVNLLTFLGQLLIFLIGFGLVATILRRSLVQDSPKMKIGTYI
                     VVGTIVLLVVLGYVGMASFIQEGAFYIPAPWDSLSVFTISLVIGIWNWKEAVFRPFVS
                     MIIAHLVVGSLLRYYEWMGISNVFLTKVIPLAVLFIGIFVLFRGFKKIKWSEV"
     gene            complement(20139..20459)
                     /locus_tag="AC0DU4_000550"
     CDS             complement(20139..20459)
                     /locus_tag="AC0DU4_000550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HIN4236553.1"
                     /translation="MKETQLLKGVLEGCVLDMIGQKERYGYELVQTLREAGFDTIVPG
                     TIYPLLQKLEKNQWIRGDMRPSPDGPDRKYFSLMKEGEERVSVFWQQWDDLSQKVEGI
                     KNGG"
     gene            complement(20549..20785)
                     /locus_tag="AC0DU4_000551"
     CDS             complement(20549..20785)
                     /locus_tag="AC0DU4_000551"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236554.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDETDEVSSKHCFEVVDETDEVS
                     SKHCFEVVDETDEVSNHTYGRATLTWFEEIFEEY"
     gene            complement(20835..22832)
                     /gene="metG"
                     /locus_tag="AC0DU4_000552"
     CDS             complement(20835..22832)
                     /gene="metG"
                     /locus_tag="AC0DU4_000552"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000049 - tRNA binding [Evidence IEA];
                     GO_function: GO:0004825 - methionine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006431 - methionyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HIN4236555.1"
                     /translation="MSEKNFYITTPIYYPSGKLHIGSAYTTIACDVLARYKRLMGYDV
                     FYLTGLDEHGQKIQQKAEEAGITPQAYVDGMAVGVKELWQLLDISYDKFIRTTDDYHE
                     KVVAQVFERLLAQDDIYLGEYSGWYSVSDEEFFTESQLAEVFRDEAGNVTGGIAPSGH
                     EVEWVSEESYFLRLSKYQDRLVEFFKAHPEFITPDGRLNEMLRNFIEPGLEDLAVSRT
                     TFTWGVPVPSNPKHVVYVWIDALLNYATALGYAQDEHGNFDKFWNGTVFHMVGKDILR
                     FHSIYWPILLMMLDVKLPDRLIAHGWFVMKDGKMSKSKGNVVYPEMLVERYGLDPLRY
                     YLMRNLPVGSDGTFTPEDYVGRINYELANDLGNLLNRTVSMINKYFDGQIPAYVEGVT
                     EFDHVLAEVAEQSIADFHTHMEAVDYPRALEAVWTLISRTNKYIDETAPWVLAKDEAL
                     RDQLASVMSHLAASIRVVAHLIEPFMMETSRAVLTQLGLEEVSSLENLSLADFPADVT
                     VVAKGTPIFPRLNMEEEIAYIKEQMEGNKPAVEKEWNPDEVELKLNKDEIKFEDFDKV
                     EIRVAEVKEVSKVEGSDKLLQFRLDAGDGEDRQILSGIAKYYPNEQELVGKKVQIVAN
                     LKPRKMMKKYVSQGMILSAEHDGKLTLLTVDPAVPNGSVIG"
     gene            complement(22956..24215)
                     /locus_tag="AC0DU4_000553"
     CDS             complement(22956..24215)
                     /locus_tag="AC0DU4_000553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236556.1"
                     /translation="MQNLKFAFSSIMAHKMRSLLTMIGIIIGVSSVVVIMALGDSLSR
                     QVNKDMTKSQKNISVFFSPKKSKDGSFTQKQSAFTVSGKEEEVPVEPPKPQESWVQEA
                     AKLKGVDSYYVTNSTNAILTYQDKKVENANLTGGNRTYMDAVKNEIIAGRSLREQDFK
                     EFASVILLDEELSISLFESPQEAINKVVEVNGFSYRVIGVYTSPEAKRSKIYGFGGLP
                     ITTNISLAANFNVDEIANIVFRVNDTSLTPTLGPELARKMTELAGLQQGEYQVADESV
                     VFAEIQQSFSFMTTIISSIAGISLFVGGTGVMNIMLVSVTERTREIGLRKALGATRAN
                     ILIQFLIESMILTLLGGLIGLTIASGLTALAGLLLQGLIEGIEVGVSIPVALFSLAVS
                     ASVGMIFGVLPANKASKLDPIEALRYE"
     gene            complement(24217..24918)
                     /locus_tag="AC0DU4_000554"
     CDS             complement(24217..24918)
                     /locus_tag="AC0DU4_000554"
                     /EC_number="7.6.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236557.1"
                     /translation="MKQLISLKNIFRSYRNGDQELQVLKNINLEVNEGEFVAIMGPSG
                     SGKSTLMNTIGMLDTPTSGEYYLEGQEVAGLGEKQLAKVRNQQIGFVFQQFFLLSKLN
                     ALQNVELPLIYAGVSSSKRRKLAEEYLDKVELTERSHHLPSELSGGQKQRVAIARALV
                     NNPSIILADEPTGALDTKTGNQIMQLLVDLNKEGKTIIMVTHEPEIAAYAKRQIVIRD
                     GVISSDSAQLGKEEN"
     gene            complement(24902..26101)
                     /locus_tag="AC0DU4_000555"
     CDS             complement(24902..26101)
                     /locus_tag="AC0DU4_000555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_function: GO:0042802 - identical protein binding
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HIN4236558.1"
                     /translation="MKKKNGKAKKWQLYAAIGAASVVVLGAGGILLFRQPSQTALKDE
                     PTHLVVAKEGSVASSVLLSGTVTAKNEQYVYFDASKGDLDEILVSVGDKVSEGQALVK
                     YSSSEAQAAYDSASRAVAKADRHINELNQARNEAASAPAPQLPAPVGGEDATVQSPTP
                     VAGNSVASIDAQLGDARDARADAAAQLSKAQSQLDATTVLSTLEGTVVEVNSNVSKSP
                     TGASQVMVHIVSNENLQVKGELSEYNLANLSVGQEVSFTSKVYPDKKWTGKLSYISDY
                     PKNNGEAASPAAGNNTGSKYPYTIDVTGEVGDLKQGFSVNIEVKSKTKAILVPVSSLV
                     MDDSKNYVWIVDEQQKAKKVEVSLGNADAENQEITSGLTNGAKVISNPTSSLEEGKEV
                     KADEATN"
     gene            26387..27733
                     /gene="gor"
                     /locus_tag="AC0DU4_000556"
     CDS             26387..27733
                     /gene="gor"
                     /locus_tag="AC0DU4_000556"
                     /EC_number="1.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004362 - glutathione-disulfide reductase
                     (NADPH) activity [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_process: GO:0006749 - glutathione metabolic process
                     [Evidence IEA];
                     GO_process: GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-disulfide reductase"
                     /protein_id="HIN4236559.1"
                     /translation="MREYDIIAIGGGSGGIATMNRAGEHGAKAAVIEEKKLGGTCVNV
                     GCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFNFATLRRNREAYIDRARSSYDGSF
                     KRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVF
                     AWEELPESIAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEME
                     RTNLPLHTHKVPVKLEKTTDGITIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVT
                     LNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDY
                     STIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLI
                     TAGSEEKVVGLHGIGYGVDEMIQGFAVAIKMGATKADFDATVAIHPTASEEFVTMR"
     gene            27930..28466
                     /locus_tag="AC0DU4_000557"
     CDS             27930..28466
                     /locus_tag="AC0DU4_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000709035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HIN4236560.1"
                     /translation="MKKAHVYAIPAIGAALIAVLAQISLPIGPVPFTLQNFAIGLIAT
                     VFRPREAVLSAGLYLLLGAIGLPVFAGGGAGFQALVGPTAGYLWFYLVYSGLTSSLTN
                     SKSGVVKIFLANLLGDALVFVGGILSLHFLAGMAFEKALVVGVLPFIIPDLGKLLAIS
                     FISRPLLQRLKNQAYFTN"
     gene            complement(28667..28882)
                     /locus_tag="AC0DU4_000558"
     CDS             complement(28667..28882)
                     /locus_tag="AC0DU4_000558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdbC family protein"
                     /protein_id="HIN4236561.1"
                     /translation="MAEFTFEIEEHLLTLSENEKGWTKEINRVSFNGAPAKFDIRAWS
                     PDHTKMGKGITLSNEEFQTMVDAFKGN"
     gene            28980..29300
                     /locus_tag="AC0DU4_000559"
     CDS             28980..29300
                     /locus_tag="AC0DU4_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001216095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236562.1"
                     /translation="MRHKFQQVLDKIHDFLNGHDQPDQTETNSLTATIEEAIQKQTAV
                     HLILSETSFTGDIIKYDQQGQQIIVKNFAKNVSRIIRISDIQRLRFVPSTVQTAQKNR
                     FKKE"
     gene            complement(29331..29669)
                     /locus_tag="AC0DU4_000560"
     CDS             complement(29331..29669)
                     /locus_tag="AC0DU4_000560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP cone domain-containing protein"
                     /protein_id="HIN4236563.1"
                     /translation="MQVIKRNGEIAEFNPDKIYQAILKAAQTVYVLTDDLRQNLAQVT
                     KKVVLDLQEAKVERATISMIQSMVEHRLLGAGYITIAEHYISYRLQRDLERSGYGDHI
                     AVHLHFEQIR"
     gene            complement(29681..30400)
                     /gene="trmD"
                     /locus_tag="AC0DU4_000561"
     CDS             complement(29681..30400)
                     /gene="trmD"
                     /locus_tag="AC0DU4_000561"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0052906 - tRNA
                     (guanine(37)-N1)-methyltransferase activity [Evidence
                     IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HIN4236564.1"
                     /translation="MKIDILTLFPEMFSPLEHSIVGKAREKGLLDIQYHNFRENAEKA
                     RHVDDEPYGGGQGMLLRAQPIFDSFDAIEKKNPRVILLDPAGKQFDQAYAEDLAQEEE
                     LIFICGHYEGYDERIKTLVTDEISLGDYVLTGGELAAMTMIDATVRLIPEVIGKESSH
                     QDDSFSSGLLEYPQYTRPYDYRGMVVPDVLMSGHHEKIRQWRLYESLKKTYERRPDLL
                     EHYQLTVEEEKMLAEIKENKE"
     gene            complement(30390..30908)
                     /gene="rimM"
                     /locus_tag="AC0DU4_000562"
     CDS             complement(30390..30908)
                     /gene="rimM"
                     /locus_tag="AC0DU4_000562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465641.1"
                     /note="Essential for efficient processing of 16S rRNA;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimM"
                     /protein_id="HIN4236565.1"
                     /translation="MNYFNVGKIVNTQGLQGEMRVLSVTDFAEERFKKGAELTLFDEK
                     DQFVQTVTIASHRKQKNFDIIKFKDMYHINTIEKYKGYSLKVAEEDLNDLDDGEFYYH
                     EIIGLEVYEGDSLVGTIKEILQPGANDVWVVKRKGKRDLLLPYIPPVVLNVDIPNKRV
                     DVEILEGLDDED"
     gene            complement(30938..31726)
                     /locus_tag="AC0DU4_000563"
     CDS             complement(30938..31726)
                     /locus_tag="AC0DU4_000563"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HIN4236566.1"
                     /translation="MKRFEVSTEIGSLSVTYKKQKKVLVCLNGAGLLPSYENFSLILE
                     KPPPTIGYLTIDFPNTGRSPIHDQAGKNLDNLADAVYEVLEELGISEYILCAHSWSGI
                     LACKLLEKPIKCQTLVAIEPTTKKVMFADFSENPYPEMEEQMRLIDECGPELYFKNLT
                     QATFSPETNKKIWELMQEKGLELENQDPEFQISGEITEEDFENLSIESHVPVFIFCQT
                     YREKEYRESEYWTSNTKLILGRNHHYLQWSESEKIAAIIRELSE"
     gene            complement(31830..32142)
                     /locus_tag="AC0DU4_000564"
                     /pseudo
     CDS             complement(31830..32142)
                     /locus_tag="AC0DU4_000564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000654120.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MazG nucleotide pyrophosphohydrolase
                     domain-containing protein"
     gene            complement(32303..32542)
                     /gene="kphA"
                     /locus_tag="AC0DU4_000565"
     CDS             complement(32303..32542)
                     /gene="kphA"
                     /locus_tag="AC0DU4_000565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein KphA"
                     /protein_id="HIN4236567.1"
                     /translation="MDTIENLIIAIVKPLISQPDALTIKIEDTPEFLEYHLNLDQSDV
                     GRVIGRKGRTISAIRTIVYSVPTEYKKVRIVIDEK"
     gene            complement(32562..32834)
                     /gene="rpsP"
                     /locus_tag="AC0DU4_000566"
     CDS             complement(32562..32834)
                     /gene="rpsP"
                     /locus_tag="AC0DU4_000566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HIN4236568.1"
                     /translation="MAVKIRLTRMGSKKKPFYRINVADSRSPRDGRFIETVGTYNPLV
                     AENQVTLKEDRVLAWLANGAQPSDTVRNILSKEGVLKKFHDSKFSK"
     gene            33004..33213
                     /locus_tag="AC0DU4_000567"
     CDS             33004..33213
                     /locus_tag="AC0DU4_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000953868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236569.1"
                     /translation="MLSVNTILEKFYKEHQVKPFISPERDLDTWLLSPKPVPKRNMDL
                     LADDSLAGDIILLWRIQFGTFTTET"
     gene            33695..33907
                     /locus_tag="AC0DU4_000568"
     CDS             33695..33907
                     /locus_tag="AC0DU4_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236570.1"
                     /translation="MSFYGLFYNGIAITPNTYLSAWFVNFIAALPLNFLIVEPIARFI
                     LSSFQKPFTGEEVEDFQDDDEIPTII"
     gene            33991..34794
                     /locus_tag="AC0DU4_000569"
     CDS             33991..34794
                     /locus_tag="AC0DU4_000569"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA];
                     GO_process: GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HIN4236571.1"
                     /translation="MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVA
                     AQSAKELNDALTNENANFPQLSKEVAEDEAEVILHTSQGDIRIKLFPKLAPLAVENFL
                     THAKEGYYNGITFHRVIDGFMVQTGDPKGNGTGGQSIWHDKDKTKDKGTGFKNEITPY
                     LYNIRGALAMANTGQPNTNGSQFFINQNSTDTSSKLPTSKYPQKIIEAYKEGGNPSLD
                     GKHPVFGQVIDGMDVVDKIAKAEKDEKDKPTTAITIDSIEVVKDYDFKS"
     gene            complement(34850..36391)
                     /locus_tag="AC0DU4_000570"
     CDS             complement(34850..36391)
                     /locus_tag="AC0DU4_000570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002918612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HIN4236572.1"
                     /translation="MSILEVKNLSHGFGDRAIFEDVSFRLLKGEHIGLVGANGEGKST
                     FMSIVTGKMLPDEGKVEWSKYVTAGYLDQHSVLAERQSVRDVLRTAFDELFKAEARIN
                     DLYMKMAEDGADVDALMEEVGELQDRLESRDFYTLDAKIDEVARALGVMDFGMDTDVT
                     SLSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDI
                     PFLNDVINIVYHVENQQLTRYSGDYYQFQEVYAMKKSQLEAAYERQQKEIADLKDFVA
                     RNKARVATRNMAMSRQKKLDKMDIIELQSEKPKPSFDFKPARTPGRFIFQAKNLQIGY
                     DRPLTKPLNLTFERNQKVAIIGANGIGKTTLLKSLLGIISPIAGEVERGDYLELGYFE
                     QEVEGGNRQTPLEAVWNAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQAKVRF
                     CLLMNRENNVLVLDEPTNHLDVDAKDELKRALKEYRGSILMVCHEPDFYEGWIDQIWD
                     FNNLT"
     gene            complement(36393..36875)
                     /locus_tag="AC0DU4_000571"
     CDS             complement(36393..36875)
                     /locus_tag="AC0DU4_000571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000976721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005576 - extracellular region [Evidence
                     IEA];
                     GO_process: GO:0046677 - response to antibiotic [Evidence
                     IEA];
                     GO_process: GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HIN4236573.1"
                     /translation="MMKKTYNHILVWGVIFYSICIVCFCFTPQEQSTVGVGTPGIQHL
                     GRLVFLLTPFNSLWKLGEVSDIGQLCWIFLQNVLNVFLFFPLIFQLLYLFPNLRKTKK
                     VLLFSFLVSLGIECTQLILDFFFDFNRVFEIDDLWTNTLGGYLAWLLYKRLHKNKIRN
                     "
     gene            complement(36875..37960)
                     /gene="rlmN"
                     /locus_tag="AC0DU4_000572"
     CDS             complement(36875..37960)
                     /gene="rlmN"
                     /locus_tag="AC0DU4_000572"
                     /EC_number="2.1.1.192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000804770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:0016433 - rRNA (adenine) methyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0030488 - tRNA methylation [Evidence IEA];
                     GO_process: GO:0070475 - rRNA base methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="HIN4236574.1"
                     /translation="MKPSIHSLAHQTMQEWVLEQGEKKFRADQIWEWLYRKRVQSFEE
                     MTNLSKDLIAKLNDQFVVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMRQHYGLS
                     VCVTTQVGCNIGCTFCASGLIKKQRDLNNGEIVAQIMLVQKYFDERGQDERVSHIVVM
                     GIGEPFDNYNNVLNFFRTINDDKGMTIGARHITVSTLGLAHKIRDFADEGVQVNLAVS
                     LHAPNNELRSSIMKINRAFPIEKLFAAIEYYIETTNRRVTFEYIMLNEVNDSVEQALE
                     LTELLKNIKKLSYVNLIPYNPVSEHDQYSRSPKERVLAFYDTLKKKGVNCVVRQEHGT
                     DIDAACGQLRSNTMKRDRQKAVAAVNP"
     gene            complement(37981..38511)
                     /locus_tag="AC0DU4_000573"
     CDS             complement(37981..38511)
                     /locus_tag="AC0DU4_000573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YutD family protein"
                     /protein_id="HIN4236575.1"
                     /translation="MRKEIAPELYNYNKFPGPEFHLHGDKVETEGIAFSLVENIKDAF
                     DVTTFNQRFSEVLTKFDYIVGDWSNEQLRLRGFYKDDRTEEKLEKISRLQDYLLEYCS
                     YGCAYFVLENEAPKRASFDKKMRKTEEETPSRKGKKPTQTKRKSNADKKNRRRQKDQH
                     SQKEDKGQRHFVIRQK"
     gene            complement(38667..39272)
                     /gene="sodA"
                     /locus_tag="AC0DU4_000574"
     CDS             complement(38667..39272)
                     /gene="sodA"
                     /locus_tag="AC0DU4_000574"
                     /EC_number="1.15.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004784 - superoxide dismutase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase SodA"
                     /protein_id="HIN4236576.1"
                     /translation="MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALE
                     KHPEIGEDLEALLADVESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAA
                     IDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPIL
                     GLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK"
     gene            complement(39445..40482)
                     /gene="holA"
                     /locus_tag="AC0DU4_000575"
     CDS             complement(39445..40482)
                     /gene="holA"
                     /locus_tag="AC0DU4_000575"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HIN4236577.1"
                     /translation="MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDS
                     ADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVILDYFMDITTAKKRFLTDDELKSF
                     EEYLDNPSPTTKLIIFAEGKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQK
                     QGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKADSVIEEEDIVNAIPKTLQDNIF
                     DLTQFILTKKMDQARDLVRDLTLQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQI
                     ASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDYQIKTGLYEKGFLFE
                     KALLQIASQVN"
     gene            complement(40516..41451)
                     /locus_tag="AC0DU4_000576"
     CDS             complement(40516..41451)
                     /locus_tag="AC0DU4_000576"
                     /EC_number="1.3.98.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004152 - dihydroorotate dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate oxidase"
                     /protein_id="HIN4236578.1"
                     /translation="MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVT
                     KTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNRTFFLSLV
                     GMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTK
                     PLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGI
                     GGEYIKPTALANVHAFYQRLNPQIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKE
                     GVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID"
     gene            complement(42004..43194)
                     /gene="metK"
                     /locus_tag="AC0DU4_000577"
     CDS             complement(42004..43194)
                     /gene="metK"
                     /locus_tag="AC0DU4_000577"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004478 - methionine adenosyltransferase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006556 - S-adenosylmethionine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HIN4236579.1"
                     /translation="MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAE
                     TAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSP
                     DIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRL
                     AELRKSGEISYLRPDAKSQVTVEYDENDRPVHVDTVVISTQHDPEATNEQIHQDVIDK
                     VIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFS
                     GKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVA
                     ESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALK
                     EAVK"
     gene            complement(43409..44752)
                     /locus_tag="AC0DU4_000578"
     CDS             complement(43409..44752)
                     /locus_tag="AC0DU4_000578"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HIN4236580.1"
                     /translation="MSFTKFQFKNYIREALEELKFTTPTEVQDKLIPIVLAGRDLVGE
                     SKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRV
                     VNYVGGTDKARQIEKLASNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLD
                     MGFLETVDKIAGSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTID
                     NWLISTKGHDKNAQIYQLTQLMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDI
                     APRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTG
                     RNGLPGTAITLYQPSDDSDIRELEKLGIKFSPKMVKDGEFQDTYDRDRRANREKKQDK
                     LDIEMIGLVKKKKKKVKPGYKKKIQWAVDEKRRKTKRAENRARGRAERKAKRQTF"
BASE COUNT        13281 a         9815 c         8116 g        13656 t
ORIGIN      
        1 cttccaaacg aggaaactct cgtaaacaaa gaggttttag aggcctattt accgtggact
       61 aaagttgtac aagaaaagtg caaataagaa atctccagat taggaactat ccgtgagttc
      121 tctagtctgg agatttttca atagacttcg ttattggacg gttaccaagt tactcaaagt
      181 acagatttga agctgcagat aagactgacg aaatcacttt aatactaaat gaaaatcaaa
      241 aagcaaacta agaagctagc ctcaggctgt acttgagtac ggtaaggcga cgctgacgtg
      301 atttgaagag attttcgaag agtataaaac actgttttga ggtggtggat aaatcggctg
      361 ggtaaaaact caatctcagg agaaaatgaa gtaaatctcc ccgcaactat agaaaaagat
      421 ttgattctgc tcctcacaca ataaaatctt tttcttttat taaaaacgaa tcgtttcacg
      481 tgttttctca tatgaggtaa caaagcgatt agttacacca ggctctgcca cttccaatgc
      541 ttgagaaatc ttgtcaaatg aagcgtgata atcaaattct ttttcaaaaa tatctaaagc
      601 ttcgttaaat gcttcttgaa tgcgttcatc aaatgagcga tagcggttag aatattgcaa
      661 gagttgctct gtcaaagttg catattgtac aatattataa gtttccgttt ctaaagcttc
      721 catatcattc gttgcaattt caagaactcg ggtaacagat tcaatgttaa tcattttttg
      781 ttctaactca accattaaat cctcggtatt attgcttgcc gtaaagaata acttcaagaa
      841 agtttgtgga atacctggca gattgcgttt ttccatgtat cgcttgatag tatggagacg
      901 attgacataa acattggcct tttgacgtgc attaatatca tctttctcaa tttgtgtcag
      961 gcgctcacta actgaaattt gctcatcttc aatatctttt agttgagttt gtaaatcctc
     1021 aagattttct tcaagaactg aataagcttg ggttggttct tcttgattcg aagttacctc
     1081 aacaatagct gcctcaaaac tctctaattc tgtctgaata cgacgaacat ggcttgcagc
     1141 tgtctcagga agtaaatagg tcttgttcaa acgtgcaata tcttctccca ataaagtatt
     1201 attctctttc atatgttgaa ggtaagttgg aagagttgca agtagatttt ccactacttt
     1261 ctgagcagca atttctcgag taaaaatatc atacaaggca ttgatttcct cttgtgcctg
     1321 tccattctca tattcggcat tatccaattc caactgacga atattctctt ggtttttctt
     1381 gaatgcttca taaagcaagt ggaaacgcgc ttcaatatcc gtttcaacaa aatgataatt
     1441 agcatcaatt agtttacgat aaccggcttc caaatcctgt aattgatctg gcaattctgt
     1501 agaaagcgtc gtaaccaagg ctggaacacg atccacaata tgacttaagg ccaaaatgtg
     1561 attttctgta ttatccaaaa tcactgcggc ttccacaggg tcacccgatg aattcaaggt
     1621 tacaaattgt gaaaattcag attggatatt ttctaattgt ttttcaattt catccaaggc
     1681 ttgaccatac tgttctgaat tttcagcaac tctatgctga agttcctcaa ataaatccaa
     1741 agcatgaaga acacgaccac tatttttaga ttcttgcttc tctaagtctg ccaaagcatt
     1801 gcgaattgcc gcaatatctt cttcaatcaa agtaatttga ctctcaattt ggtcaatttg
     1861 atgactggcc ttgagaaaac gaaatgaatg gttatagctc tctgcttcaa agagattatt
     1921 ttcaatatcg gcaaaagagt tgagagataa atcgacccat ttttgattcc attcacggaa
     1981 agccacttga ctttgtccaa tcaagtgcat attttttaca gcttctactt catcatttac
     2041 tggaagattg tatagttctt cttttctttc ttctagtgcc tctaatctcc cctcgtttcg
     2101 cttacgtaga aagattgcca ctacataagc cagaactaaa atgactgcaa ttgcaaccat
     2161 taaataaatt agttgtccat tagacatatc aaactccttt tttacttgaa acaatcgtaa
     2221 cgattatatc atatttttta gaccaaggga actacttctc cctatttttt agacatcaag
     2281 tgtactatag acagcatttt cttcgataaa ctcacgacga ggctctactc gatcccccat
     2341 caacatatca aagattttat ctgcttctgc agcatcatct acagaaactc tagccatcaa
     2401 gcgatgttcg ggatccatgg ttgtttccca cagctgatga tcgtccattt cacctagccc
     2461 cttataacgc tgaatagtcg gtttggtacg accttcacta taacgggcta aagcttcttg
     2521 gagtttgatt tcttgatctg cacccggctg gatatattct ttaatctcgc ttccaacctt
     2581 gacaccatag attggtggtt gggcaatata aacataacca gcttctagga ttggtttcat
     2641 ataacgataa atcaaggtta aaagaagggt acgaatgtgg gctccatcga catcggcatc
     2701 ggtcatcaaa acgagttttt ggtaacgggc tttcgaaaca tcaaattctg cgccaaatcc
     2761 tgttcccatg gctgtgaaaa gactacgaat ttcttcgtta gctagaatct tatccatact
     2821 tgctttttca acgttcaaaa tcttaccgcg aattggaagg atagcctgaa actcacggtt
     2881 acgaccagat ttggctgatc caccagctga gtctccttcg acgatgaaga gttctgtttc
     2941 agcagggtta ttagaagaac agtctgctag tttccctgga aggttggaaa tttccaaacc
     3001 agatttttta cgtgtgactt cacgcgcacg cttggcagcc acacgagcct tggcagccaa
     3061 aattcctttt tctacgatac gtttggcaat ctgtggattt tccatgagga aatcggagaa
     3121 ggcttcactg aagaggcgat tggtaatctt gaccacttcg ctatttccca atttggtctt
     3181 ggtttgtcct tcaaactgtg gatttgggtg tttaactgag ataactgcag ttaagccttc
     3241 gcgaacatct tcccctgtta ggttgtcttc attgtctttc agtaacttat ttttacgagc
     3301 ataatcattg ataacacgtg tcaaggctgt acggaaacct tgttcatgcg ttccaccttc
     3361 atgtgtatga atattattgg cgaaactcat gacattttca tggtaaccag ttgtgtactg
     3421 catggctacc tcaactgtga tatcatccat ctcaccgtct gtatagattg gtgtatcaaa
     3481 gattacatcc ttgttctcgt tgatatattc aacgtaacta gcaatcccac cttcataatg
     3541 ataatgcttg gtttgttcca aaccttggcg cttatcagtg atagaaattt gaagaccgcg
     3601 atttagaaag gccaactctt gaatccgttt atttaattta tcaaaatcaa agattgttgt
     3661 ttcagtgaaa atttctgggt ccggtgtgaa gtgaaccgtt gttccagttc tatctgtatc
     3721 cccaaccacc tcaaggtctg caacaacatg accacgacgg tattcttggt aatgaatctt
     3781 accgttttta tggacatgaa cgtctaattg agtggaaagg gcattaacta ctgacgaccc
     3841 caccccgtga agaccacctg aaaccttgta tccaccaccg ccgaactttc ctccagcatg
     3901 aaggactgta aagacggtct caacagcagg acggcctgtt ttttcctgaa tatcgactgg
     3961 gataccacgc ccatcatcca caacagtaat cgaatcatct ggctcaataa aaacttgaat
     4021 atggctggca aatcctgcca aggcctcgtc aattgagtta tcaacaattt cccagactag
     4081 atggtgaaga ccttcttttg aggttgatcc aatgtacatc cctggacgca tacgaacagc
     4141 ctctaagccc tctaaaactt gaatttgact ggcatcataa tcctgtgcct gcagattttt
     4201 gatttcttct gtcatcttat tcctttttct tatatgtcta atacttgtct taaattcacg
     4261 atactggtaa acaagtgggt atcaagtcct gcagcttgac ctgcttcgat atcaatcggc
     4321 cgatcaccaa tgacaagacc agagctaatc tgatactttt ctcttaaata aagcatggat
     4381 tcgggatttg gctttctctt aaagcctgag ctagaagtca ccacttctgt aaaataagct
     4441 gctatagagg ttttttctaa aatttccaaa acctgatcat ttcgatgaga gaccaaaaaa
     4501 tgacggccac cttgatttga aatgacttcc aataggtcag aaactccttc aaataaaatc
     4561 gggtgttcaa gctctctggc ttcattttcc ttgtactttt ctcaaaaatt ctctaaattg
     4621 ggagcgaatg tctcaatcgc aaaagaagta gaaaccttta aagcttgata gacactgtca
     4681 tggtcttgtg tgataccata cagtgccaat gtttcaacaa atgcagctgt tgaagtttca
     4741 taattatcca gtaaagttcc acctaaatcc cagatgtaat cgtgatattt catacccttc
     4801 attatagcat ttttttatga aaaaagcgat gatttccctg agttttccac ataaaaaacg
     4861 agagaataac tcccgtttta ctgattttta ccaaagacat ctcgatagag cattcctgtt
     4921 cgtaaactct ctgcgtcccc tcctagttgc tccaccaact cgtaggcaaa ggcaagggct
     4981 gttgaaggac cccgactggt tgtcaactga ccatctacca ctactgtttc cttgacgtag
     5041 tgaccatcaa ggatttgctc ttgaacgccg tcataacaag tgtatcgctt atttttcaat
     5101 atctctgctt gattgagggc aattggtgcc gcacaaatgg ctgctagttt cttcccttct
     5161 tgctcgaagc tttgcaattc ttgaatcaag gtctgattat cacgtaaatg tgcagaacca
     5221 ggcatacctc caggaagaac aatcatatca tagtctgata aatttccatc aaagacatga
     5281 tctgctctta cttggattgc atgcgaaccc gttacttgct cttcaaaacc aaccatatca
     5341 catgtgatat tggctcgacg caagacatct acaactgtca aggcttcaat ttcttcaaag
     5401 ccctgagcta acataactgc tacttttacc atgattttct ccttatttaa tttgttttaa
     5461 tacaaccttt ttccgtttga atgggacttt tccgctcttt tcttcagcta gattagtctg
     5521 gtaactcatc gataaaagca aaccaacacc aatcagatta ctgataatag ctgatccccc
     5581 ttgcgaaatg aaaggcaagg gaatccccgt caaaggaagt agtccagtca cagcaccgat
     5641 attctcaaag atgtggaaga gcaacatcat aatcaaacct gtggaaatat aagtgtagaa
     5701 ctggttattt gatttaagag taatcttcaa catacggtaa atcaacatga gatagagggc
     5761 aataaccagg acagagccaa taaagccaaa atcttctgca ataaccgtaa aaatcatatc
     5821 tgactctcga actgggataa gcagattcga agcattaaat ccctgaccaa ataagccacc
     5881 actcccaatg gcaatctgcc cttgagcctg ctggtaagtc gttgtttggg caaactcaaa
     5941 gggattgagc caagccaaaa tccgattgat ttggtaggtc ggcattccaa tctggtgaag
     6001 aaaagctcgt ccgtccttgc taataaagat agctaagaaa ccagcaactc ctgttacagc
     6061 agtcacaaat actgggataa taattttcca agaaacccct gataataaaa cgattcctga
     6121 gaaaatggct acaaaaacca aagccgtccc caagtcactt tgaagtgcta aaagaactag
     6181 gactggaatg gtaaagagaa tcatccagaa aattaacaaa aagtccagcg gaaccgtgcg
     6241 tctccattcc ttatgtttct ttgtaaattg gacaatgaca cgagccaaca tgaggatata
     6301 agatatcttc ataaattctg acggttggaa tagggtaatt ccatttattg atacccagtt
     6361 tttggcaccc gttgatgcaa ctaatcttgg attataaaat acaatcggca agatcataag
     6421 tcccaagcct aaaatatata gaaagggggt caccttccaa agaaattctg tattaaagag
     6481 catgaccaca aaaccaatca caagccccaa ggcaatccag gcgacctgct gccctaaaat
     6541 gggcaaaata ttattgggat aatcatgact aacggctata tagatagcca ccacaccgat
     6601 gaccagtaga aaaaatactg gcaagagcaa actgtaatcg actcttgagt cgagagaacg
     6661 tttcatatat actaacctta tactttcata caatactatt tatcaaagtt cattaaaaaa
     6721 tctatcaata gcctcgtcaa cttcggatcg agagatggtt ttaacagtcg cttcttctgc
     6781 tagagatact actatttgtt tgccgtatcg ttttccgacg attctcctat ccaaaataag
     6841 agttaaggaa cgttggtatt cacgtctcat acttcttccc aaagcctgtt ttaaacgaat
     6901 aatggccatt ggcaattgat aatcataaaa ggcatttttc ccttcttgat tcagttcttg
     6961 attaatcttt ttcgtcaagg gttcttgagg attttggaaa ggaagcctcg gtacaacttg
     7021 aatcacaaaa ggatggcttg aaaaatcaac tccctcccag aaacttgctg caccaagcaa
     7081 gatttgttgt tcaccttttt caaagcgttt ctttagctga tgaacatccc catttttata
     7141 ctgggccaag tggctaactg taagtaaatc cgatactgct agaagcatgt ctttagcggt
     7201 aaagagaacc aaaatcggtt gctggaaagc ttgaatttcc actagtaaag cagctacctc
     7261 tctggcatag acttctaagg aggtttctgt taccagaggg aaatctttga ccatgaccac
     7321 ttcttgttcc tgttttcccc gagattcaat cttgacaaat ttggcttcag gatagcctaa
     7381 aaggtctgcc aaagaaaccc tctgactaat ctcaagagta gccgatactc ccaagacttg
     7441 gcaactctca ggaagtaaag aggacagaag agtacggcat gattttgtag aagaaatctg
     7501 aattttcttt tgactcgttt cagttacttc aagccagtaa tcaccttcag ctgtaaaata
     7561 gcgaaccagc tcatcaaagc cttctacttc taattctgaa aaatactgat ggagattgtc
     7621 cagagaatct aagatatttt tcctagattt accagactga aattgttcta tcaagtagag
     7681 acactcaaag cgaatacttt ctagtatccg ttgttgaacc ctgttttctt ctcctactaa
     7741 agccttatca attaaatcga taatagattg tatatcgtag gtctcttgaa gcagattttc
     7801 tagagctaac aaaatctttt ggacttcatc aataatcagt aaacggtcac tgacaaattc
     7861 aggattatct tcaagtctgg tcacgagata ggcatgatta gtcactaaaa gcttgcaagt
     7921 ctctgccctt tcttgactac gtttccaaaa atcttccgtc acaaataagc tctgggatga
     7981 taaattccca tcatgacgaa ggtctgctag aaaatgttgg taacggtaga gttgcccgat
     8041 ttcatccaaa tctcctgtct ctgtctcagt aagccagacc aagacttgca ttttaaagcg
     8101 tctaaataag cgattttcat cattttcctg caaggaatga taaaaggcat ccaacttcag
     8161 ataattttgt ggtcccttta agctatgaat atctgtatgg aacacttcct tgaggcgttt
     8221 accttcttct tccatgattt gattttgaag aatctttgtc ggaacactaa gaacaatttg
     8281 tcgctctttg gattgagata aagcgggtaa gagatagcca taggttttcc caatccctgt
     8341 cggcgcttga atcagagaga caggttcatc tttcaatagc aagccaacct ctttagcaaa
     8401 actttcttgt tcctccctca cttcaaggtt caacagagaa atatttttag aaaagtcttg
     8461 agatagtttt cgtggctcca gagaagctgc cgttttctta aaatacagac cttgaacttg
     8521 gaccaagtct ggagaactca ggatagattg gttgcgataa gtttcctcaa taaccaggta
     8581 ggactcatat aggagagcgt cagccatttc cagcaagcgt tccaagagac ctttaggaag
     8641 ctgggtcatc ttttcccgta aaaaaagaag taattctgct gtagcttggg catctgaaag
     8701 ggctgtgtgt gcgtgtttaa gaggaattcc taattctcga cacaaaatcg gcaagctata
     8761 tttttccagt tcagggaaaa agacctgggc caattcgacc gtatcaacac gagggtttct
     8821 tagctcatag ccttcaaaaa ataaattttc cgccaagaga ttagcatcaa actgaacatt
     8881 atgggctaca aaaatcccat cctccaccaa gtcaaatatt tttctggcaa cttgcgaaaa
     8941 atcaggtgct tgcgccagac gttggtctgt caatcctgtc agttctttga tatgagcatc
     9001 caagggttca tgtggattga catccgtcgt atagtgatcg acgatttctc cgtcctcaat
     9061 cacgacaatt cccacttgga taattttagc cttactacct gtgctagttg cctctaaatc
     9121 caccacaaca tagcgattac caatcgtttt cattataaaa aattatacca aaaaaagggc
     9181 catttggcac ctgcaaacat aggataattt tcaaactcaa gaacactact tttcttaaaa
     9241 atcccatcga atagagcatt ctagcctgct gatttttgta aaatagtgaa gaaatacgaa
     9301 aaattgagag aagaaatgtt tgcatcttcc ttctctcaac gaatcatgta ttttatctaa
     9361 ccatgtcagg atcgtagtca taaaatcctg tatcaaggaa acggttttta gggtgaagtt
     9421 tacgaacttc ttcatccagc aagaaggctt gatcatggct aaagttgccc tcttgaatca
     9481 agttacgcgc ttggataaag agttttgcaa tctcaacaaa gttctgacca ggagtgtaga
     9541 gcccttctag tttccagcga gtaaagccat gctccaccaa ttctgttaat ttgatcatca
     9601 aatcaaggtc attgttggca aagatatggg tcccatgatt atcttcaaaa atggaatagt
     9661 ggctctctgg atcacttggc tcagccaaga agaggtcacg tttatgcgtc ttttcatcat
     9721 cgatatgtgt aaagttatag tagttttgca agagtggacg tttagaatga tggatgacgc
     9781 tagcaccgta aaccaaaact tcagcaggaa tttccaaaat ctctggcatt ttgaaaagtt
     9841 cagctgatgg aatttcacgc gccaaaacag cctcagatgc gccagccttt tgtccccaga
     9901 agttaatctg acgactgcta gttaccatgg ttgaagcatc gtagatggtc ttaaatgaat
     9961 aaccatcgcg gttaactacg taaaagacgc ctgcatcccc aatcgtaata tagtctgtct
    10021 tgatttcttc caagaagtct aagaaaggct tgatacggtc catcatatct tggtgcatga
    10081 gagcattgac cgcaacgatc aattccttac cagcatcatg aaccaactta gcgatttcac
    10141 gtaattggtc ataactaaag gtcgttggca gacgaaggcc aaaatctttc tcaccgacat
    10201 agatacggtc tacgccagct tcgagtagtt gttcaacttg ttcaatactt tcagcagttg
    10261 ctgtaatgac aatcttttcc ataagaaaaa ttataccaca tttctccaaa atcatccatg
    10321 ctttgaaaat gaaaagggac tttattcttt ttgtaacctt tctgtaataa ttctctgccg
    10381 aaaaaatgat aaaataggta tgtactgtta aggagagaat tatgcccgta agaaaattac
    10441 aatcctatga ggtagactat caagaagaat taaaccagca gcttcctcat taccaagctt
    10501 atacacctga agcgcaatct gatgccaatc tcaaggaaat cctatttttt attaatatcg
    10561 ctgttttttg tatctgtatt gctatcttta gttttatctt tttagcatta aaattatcaa
    10621 ctgctcttgc ctttgccgca gcaatcggat tcagcttact tgttttaaaa gttcaacggt
    10681 ctattatcaa acgaaaacgt agaagataaa tccaaaatat cgccccagtt ggagcgatat
    10741 ttttattttt tctttttaga tggtgtctga atggcaatct tcacttcaaa gattgttccc
    10801 ttgggtttat tatctttgac agtaacagtt ccttttagag catctacaat ttgcttggct
    10861 agggataatc ctaaaccaaa accacctttt tgccgggttc tagccttgtc tactcgataa
    10921 aaacggtcaa aaattttctt tttatcttct gtcgaaatac cgattccatt atcagaaaca
    10981 agtaaataaa gattgcgatc ggtcgccgag ataagaaaat caatttcacc atcctcctca
    11041 gtatacttga cggcattatc gaaaagaatg gtcatcagtt gtttcagaag aagctgatct
    11101 gtgacaattg ttcgatggat acgattttca aaacggaaga cacgattatt ttccgaagca
    11161 atcatctcgt agtttgtgaa agttgtatta aaaaagctag ttggaacttc tgcaagctcc
    11221 ggcttaatcc catcatctct ccgagctaag ttcagcaagc ttgtcgttaa aaaacgcata
    11281 tttcggactt cttccaaact cgatgcaatg ctttcgctca catccataat ggtagcttct
    11341 ggcttacgaa aaagggtctc taagcgattt tgcaaaactg cgagtggagt tcgtaactca
    11401 tgactggcat tttccacaaa agactgttgc ttctgcatac tctcaagcag gggcctaaca
    11461 ctgaccctag ctagatagag actggcaagt aaagacaaaa tccagaaact agccatcacg
    11521 accacaatca attgctcatg cttttgacta gcctgttcca actgactggt attaatcaag
    11581 acagcagcat acttgatatt ggttgaaacc gaactaatat tggtctccat caaaatcaca
    11641 cgatagattt cttcctgccc atagctatta aaaacctgaa tctggtagat atgtcctagt
    11701 tctttctttt ctaacttaat cttatccaag cccaaaaatc gatttccaga aagaagttga
    11761 gtaaagtctt tatcaaagag aatgacttcc gtattggaac tgacattagg ttttatttct
    11821 actttactag cgtccgccct agcattttct aaatctttaa tctcttctgt tgccctattt
    11881 atagccagct gaataactgc ttgaggattt tcactcagtc catgaagctt atcgtccacc
    11941 gaagtataaa gactcgaatg catgacttgt aaaataatca gagtcattgt agaaaaaatc
    12001 agggtgaaga caccgaagtt gcggataaaa taactaaagt catccgcata ccatgttttt
    12061 ttaagtttac tgaacatctt ttaaaagata cccaacacta cgcaaagttt gcaaattctc
    12121 tgcaaaagtg gttcccttta atttcttacg gacttttgaa acatagactt cgacaaccga
    12181 aatcgttgta tcactatcaa atccccatag acggtcaaaa atctgcgtct taggtaaaat
    12241 cacattttga ttttgaagga aataaactag taaatcgaac tctttcccca gcaattcgac
    12301 aggagtatct tcaactttaa cggtattggt tgataaatta accacgatat tcccataagt
    12361 caaggtgttt tcattaaact tccctgaacg tttgagaaga gcctgaatcc gcattttaag
    12421 ttcttctagg tagaaaggtt tggtcagata atcatccgct cccagttcaa atccatgtcc
    12481 cttgtcatcc aaactttcct tggcagtcat aatcagaact ggtgtcgtaa ttcccttttc
    12541 acgcaattct tttaagactt ggaaaccatt tttttctggc aacatcaaat ccagcaaaat
    12601 caagtcatag acaccactct cagcttcgta gagaccttct tctccatcaa atacctgcat
    12661 aacatccgca aaatcgtcta aaaagtcaaa tactgaattt gacagaccta ggtcatcctc
    12721 aaccaataag atttttatca tgagaaactc ctccttatta aaactattat accaaatttg
    12781 ccttaaaaaa aactcaactc tctgcatttt acatgagata gctgagtttt ctttttattt
    12841 taggcttatt tatgcatttc cgtattgaag aacaactgct tcgactgcag ctttttcacg
    12901 gctaatcaag tcaacacgcg ctgcaatttc cttgattccc ataccgatgt tacggctaag
    12961 agcaaggtca gaaagttgcg gctcaaagaa ctccttgtat tccgccaagc gttgctgagt
    13021 cttaaataca tgagcaggaa ggataacaaa gctatcaaag ctcatatctc ctccaagggc
    13081 tgccttaatc caagcccagt tttcacgcgc ccaagaccaa gctgttttct gagttgcttg
    13141 atgagctagg aattggtaat accaagcaga caagtcctgt ggtttgacca caaatttgtc
    13201 cttccaagaa gtaatcaggt tttggatatt atccgcatct gtactgtatg caagagctgc
    13261 tgccaactgg cgtttaaaga cagcatctgt tgcgtgagta taagtatcaa gataaagtgc
    13321 taacaagtct ttagtctcat gatgtttcat ctcattaatc agaacttgtg agcgaatagc
    13381 tgctgggagt cctgcaagat tctccttgtg tgttgcgaag atttggctag cgacttgact
    13441 agcttctgca tcatttgagc gaatcatcat cgaaacagcc agctgacgaa ccaattcatc
    13501 ctcatctgat tctccgtctt tagcttcaaa accaagacgg tcatagttat gacgagccaa
    13561 tttagcaacc agtcctttga aggctgtttc agcatccgtt ccttcatcaa taaagcgctc
    13621 aagggctgaa atcacttgag aaacagctga aaccaccaga taagactctt ccttagcaag
    13681 tttatcaaga actggaagca agtctgcata agaaatgtgc cctgcctcag ccaacaaacg
    13741 acgttcttga acaatttgca gtttgcttgt gttatcaagt gtctctagct cagcaagaac
    13801 agcttctaac aagtctcctt gatagtcggt aatatagtgg gcagtatttt cagtgttgag
    13861 acgaagagct ccttcatttt cagcaagaag agctgcgtag ccagggattt cgatactttc
    13921 agtttcgagt gtatcaggca agcctttcca gttgctattg aggggcacca cccagagacg
    13981 gttcttgtct tcgttctcac cgatgaagaa ttgtttttgt gaaatcttca agacatcatt
    14041 ttcaacttta acagtaagaa ctgggtaacc aggctgttcc aaccaagaat ccatgaaggc
    14101 tgcgacatca cgtcctgacg cttgaccaag ggcatcccaa aggtcactac caatggtgtt
    14161 gctgtattgg tgtttttcaa agtaggcgtg caaaccttta gcaaaatcag catctcctag
    14221 ccaacggcga agcatgtgca tgagacggct tcctttggca tagacgatag cgccgtcaaa
    14281 gagtgtattg atttcatctg gatgtttaac ttcgacgtgg acagactgaa cgccatcagt
    14341 agcgtcacgt tcaagagcaa gaggtactcc acctgtttgg aaatcttcaa agatattcca
    14401 gcttggttcg atggtatcca cacagacgta ttccatcata ttagcgaaac tttcattgag
    14461 ccaaaggtca tcccaccatt tcatagtcac gaggttccca aaccattggt gagccaattc
    14521 atgggccaca acaagggcaa cttgttgacg gctagcaaat gtagagttct catcgacaac
    14581 caagtaaact tcacggtagg tcacaagacc ccagttttcc atagcaccag ctgagaagtc
    14641 aggaagggcg atgtggagag attgaggaat tgggtactta actccatagt aatcttcgta
    14701 aaactcgata gagcgaacag cgatatccag tgagaaatca agatttgaaa gtggatgtgc
    14761 tttggttgag tagacaccta ccagggtacc atttttagtt ttagcggtca ccccttgcaa
    14821 atcaccagca acaaaggcca acaagtaaga agacatgcga ggtgttgtct caaacttcca
    14881 gatacctgtt tccttacggt tttcaacatc gatttctggc atgtttgaca aggccaattc
    14941 accttctgct tggtcaaagc gaagagagag gtcaaaagtt gctttggctt caggctcatc
    15001 cacacatggg aaagcttcgc gcgcaaaatg gctctcgaac tgagtagaca agacctcctt
    15061 cttgactcca tcaactgtat aataagaagg gtaaatccct gtcatgttgt ctgtaatttt
    15121 accagaaaag gcaagaacca attcaacttg accagcctca gccaattcga tatgaagggc
    15181 ttcattgtca tggtcaactg taaatggacg agcttgacct gcaacttcta cagaggtgat
    15241 ttccaagtct ttttggtgga gggagatgcg gtcactctgt gcttgaccag tgatggtcac
    15301 tttcccagaa aaagtcttgg tctcacgact caaatctaaa aataaatcat aatgttcagg
    15361 aacaaattgc ttaataaaat gttcaactgc ttgcatagtt ttctcctatt ctaagtttaa
    15421 gagctgctgc tcttcttcaa acaaacttat tatatcatat tttgcttgag aaaaaaggat
    15481 tggacagcga tttccaaaac tttcttcctt ctaatagtct acagtgggta gaccttgcga
    15541 aattcttcta aaacaacctt gctttcaggt gtaaaagtca gccctacttc acccaaacag
    15601 tctgtgaaaa agtcctcatg aacctggcgc caataggcaa gtgatttgtc tccctcacct
    15661 tccttaaagg catgttgcgc agaaacttga ttgaagagtt caacagaaac ctttgtaatt
    15721 tcgacaatgc agacagactg attttgacta tctaaaatga catcgaaggt ccctacttgg
    15781 ggaagtggtt cgtcttctag tacatagagg tcataggctg atgctgttgc tgtcttttct
    15841 cctttaaaca ccaaatccgc taaaaggtct ggttcaactc caaaagccca agcatcgatt
    15901 tcatctccga tcaaaggatt gatttgcttg tatttattcc acatttcttg cggtatcatg
    15961 ggtactcctt tgtaattttt tactttcttc ttttatgtgt ttaagatgat ctggatggtc
    16021 aatctctaaa tcaaaaatct ctggaataga actgtagtgg ataatgcact tgatacccaa
    16081 ctgattcatt ttttgtatga aagaagtatt cagatagcct gctacagcaa aatcaatctt
    16141 gttctttctt gctttatcct gcatatctct tagcatatct aacattattg gactttccat
    16201 atcatgccat tgactgtttc tcatagtcgc aaaaacaaag gaagtcaaat cattcattcc
    16261 aactacaatc tttgaaatgc ccgtttccag tatcctatcc aagtcaaaat acgctgacgg
    16321 taattcaatc atcgttccga ctttcccagt aaagccatac tgacgcaata ctgtaatagc
    16381 ttgttttaat tggtcggcat cattgacaaa aggaaagata agagatagat tgggattggt
    16441 ttgataaact tctgtaacga catgtgcttc agcctgaaat tcatccaaac acgccagtaa
    16501 acgcctggtt cctctatagc caaacaaggg atgcccttcg tcaaaaaact ctctagtccc
    16561 cactaaacaa ttggcttctg tattcgttaa ttcagaaaaa cgataccaaa cttcttcatc
    16621 tgagtacagg gagcagatag tctctagata atcttttaca aattgctgac aacttgctaa
    16681 tatgatgttt tgattaagct ctctcaacaa atattcccca cgaatcatgc cgacgtggtg
    16741 aaatagttga ggataaattt tttcaagaat tttttcgcca ctaagggcaa gttgatttct
    16801 catcattcac cttccaattc atgtaagaag tcttgtccag ttctggaaat cctaataatt
    16861 cagacttaac cttcaagact aatggcgatg cattttcttc tgtaatctct tgaatatcca
    16921 tccaaatata tccaagtgaa tcattcgcac catcagacac agcttccgaa gtcgtaactt
    16981 gaggtgcact ctcattcatt tcaacatcat acaaggccat gacatggtga accataaaat
    17041 ttgttaactc ttctctgacg aaaacatcgt agattcgagg attagagtag cttctaacag
    17101 taaatcccgt ctcttccata acttctctag tcagcgtttc cgtcagtcct tcaccaagtt
    17161 gctgactgcc tccaggtaga tcataccgat gttgataagg gcctctcgtt ttttcaatgc
    17221 agagtaactt cccattttct aagcaaacag cgtagactcc aaagtgtttt ttgatttcca
    17281 tccaactcct cctacttcaa agaccagcca ccatctattg tcaagatttg tccttgcatg
    17341 gcgctcgctt ttccacttgc taaaaaaaga ctaagctctg ctatttcctc tggctcaatc
    17401 cagcgcttga ttggggtttc actagccacc cagtcagcca aaccacctgg ttcaaaatcc
    17461 gcagcggtca tagctgtctt gactgctcct ggagcgatac caaagacctg aatcccagct
    17521 tcagcatagt ctagagccaa ctgcttggtg aagccagcca aggcatgctt ggatgaagta
    17581 taggcgtgac cacctccacc tgctaggcta gaagcaatgg aacacatatt gatgatgatt
    17641 ccctttttat tttccagcat ttgtgtcaaa taataccgag tcaactcaac aggagtcatg
    17701 tagttaattt caaaaatctc ttgaatttcc tgcgcagtct gttccaacag tggtttgtaa
    17761 gcatccaaaa ctccggcagt attacacaaa acatccacct gagggcacca gtcaaaaata
    17821 ggttccaagt ccaaggtcaa atctctctgt aaaaagtgaa aatcaccctc taagagtggc
    17881 ttttcacctt ggtcaactcc ataaacttga tagcccttct ctaaaaagag gcgagcttga
    17941 gccaatccga tccctgaact cactcctgta atgagtacac gtttagtcat gcacttctac
    18001 ccaatccgtt gccaaaacat cacaagctgt cgggctccac atggaaaaac cttctccttc
    18061 tccagacacg ttgattaaga aataaggtgt cacttcaagt gcaagcccat tttgctcgat
    18121 ggtatcaaag agttggacat agttttcagc acctccccaa ccagttcgta catatttttt
    18181 cttagccttt aagccaggta gaatttcttc aaatgtcatg tttttctcct ttaatgtcaa
    18241 taattctccc cttcattata acaaaaaaac cgctttaaaa cggctttttg actgtgattt
    18301 atttacatct tcttctactt acggcaaatt attccctgca gcaagataaa tttcatacca
    18361 ttcttttctt gttaagctaa agtttgccgc ttggctaact tctctcaagt gcttaggatt
    18421 tgtggtacct acaactgcct gcatttttgc tggataacgc aatatccaag aaatggcaat
    18481 agttgaagag gttactccat atttaatagc taaacgatca agtacttgat ttaaagcttg
    18541 aaatttctca tttccaacaa agttcccttt aaaatacccg aattgcaaga cagaccatgc
    18601 ttgaatgacc acatcgtgta atttgcaata ttcaaaaatg ctgccatctc gcatagctgc
    18661 ttgactatct tccatattaa catgaaaagc tgattcaaat cctggagtaa aagccgcact
    18721 caattgtagc tgattaacag ctaacggctg cttgacatct tttttaagca actccatcat
    18781 cataggattt tgattagaaa ctccaaaatc tcgaacttta ccttgtttat aaaggagatc
    18841 aaaggcttct gctacttggt cagattccat caaagcatct ggtcgatgaa ggagcaagct
    18901 atctagatga tcaatcttca atctttgcaa aataccgtct actgatttta taatatagtc
    18961 cttagaaaaa tcaaaatagg taaattcttc aatgcgaatg ccacatttgg actgaatcca
    19021 catcttttct cttaaatctg gacgattttt taggacaaga cctaacagtt cttcacaacg
    19081 accacgacca taaatatcag ccaagtcgaa ggcattgatt ccaacagaaa gtgctgtttc
    19141 tacaagctct tcaacttctt ttacagactt atcttttatt ctcatcattc cgagaacaat
    19201 ttctgataat tctttgtcat cttgaccaag agttatgtat ctcatcaaat ttttctcctt
    19261 taatttctaa cattcttccc ttcattataa caaaaaaccg ctttgcaacg gctttttgac
    19321 tatacttcac tccattttat cttcttaaac ccacggaaca agacaaagat tccaataaag
    19381 aggacagcta aaggaataac ttttgtaagg aaaacatttg aaattcccat ccactcataa
    19441 taacggagca gagaacccac cacaagatgg gcaataatca tactgacaaa tggacgaaag
    19501 accgcttctt tccaattcca aataccgata actagcgaaa tcgtaaagac agacaaacta
    19561 tcccagggag ccggaatata aaaggctcct tcttgtatga agcttgccat tcctacatat
    19621 cctaaaacaa ctagaagaac tatagtccca acaacaatgt aagtgccaat tttcatttta
    19681 ggagaatctt ggactaaact tcttcgtaaa attgtggcca caagtccaaa tccaatcaga
    19741 aaaataagaa gttgccctaa aaatgtgagc aaattgactg ttaagagagg acctttagaa
    19801 aaatcactta gtagttgata ataacgtaat accgccagga caagaattgg cgtcaaaagg
    19861 gactctttga tagaactgcg aggtgctccc ttgagaatct ctttcattat ttttttagga
    19921 ttcttaccta gataatcctc tgcactcatg ccatctcgtt ctgcttctga gaaatctagc
    19981 atcatcaaat agatctgctc tctgagatag tcttcatcat agagaaatcc agcaagatta
    20041 aaactttccc acaactcctc aaaatacttt tgattctcct cagaaaactc atgtagcaaa
    20101 gcgcttgttt cttcgtaata cttcattttc ttcatggttt aacccccatt cttaatccct
    20161 tctacttttt gactcaaatc gtcccattgt tgccaaaaga ctgagacacg ctcttctcct
    20221 tctttcatta atgaaaaata cttccgatct ggaccatctg gcgacgggcg catgtcgcct
    20281 cttatccatt gatttttttc taacttttgc aacaaaggat aaatagttcc tggaacgata
    20341 gtatcaaatc cagcctctcg caaagtctga accaactcat aaccataccg ctctttttga
    20401 ccaatcatat ccaagacaca accttcaaga acacctttta atagctgagt ttctttcatc
    20461 acttctccct tctaatctat tttgtaatac ctactagtaa cttcacctat agtatatcac
    20521 ttctacacta gtttgtaaag cataatagtt aatactcttc gaaaatctct tcaaaccacg
    20581 tcagcgtcgc cctaccgtat gtatggttac tgacttcgtc agtttcatct acaacctcaa
    20641 aacagtgttt tgagctgact tcgtcagttt catctacaac ctcaaaacag tgttttgagc
    20701 tgacttcgtc agtttcatct acaacctcaa aacagtgttt tgagcaacct gcggctagct
    20761 tcctagtttg ctctttgatt ttcattgagt ataaataaaa aaacagaact agtctgaact
    20821 agtcctgtct acttttaccc aatcacactt ccatttggta cagctggatc aactgtgaga
    20881 agggttaatt tgccatcatg ttcagctgat agaatcatac cctggctgac atattttttc
    20941 atcattttac gtggtttgag gttagcaacg atttgaactt tcttgccgac caattcttgt
    21001 tcatttggat agtattttgc aattcctgaa agaatctgac gatcttctcc atcaccagca
    21061 tccaagcgga attgaagcaa cttatctgaa ccttctactt tagacacttc tttgacttct
    21121 gcgacacgga tttcaacctt gtcaaagtct tcaaacttga tttcatcctt gtttagtttg
    21181 agctcaactt cgtccggatt ccattctttt tcgactgctg gtttattgcc ttccatttgt
    21241 tccttgatat aggcgatttc ttcttccata tttagacgtg gaaagatagg tgttcctttg
    21301 gcaactacag tcacatctgc tgggaagtca gccaaactca agttttcaag actagaaact
    21361 tcttccaaac caagttgagt caaaactgca cgactagttt ccatcataaa tggttcaatc
    21421 aagtgagcaa ctacacgaat gctggctgcc aagtggctca tgacacttgc caattggtca
    21481 cgaagagctt catccttggc caagacccat ggtgcggtct catcgatgta tttattggta
    21541 cgagagatca gagtccagac tgcttcaagc gcacgtggat agtcaactgc ttccatgtgt
    21601 gtatggaagt ctgcgattga ttgttctgca acctcagcaa gaacatgatc aaattcagtc
    21661 acaccttcta cataggcagg gatttgtcca tcaaagtact tattaatcat ggaaaccgta
    21721 cggttaagga ggttcccaag gtcattagcc aattcatagt tgatacggcc gacatagtct
    21781 tcaggagtaa aggttccgtc tgaaccaact ggaaggttac gcatgaggta gtaacgaagt
    21841 ggatctagtc cataacgctc taccaacatt tcagggtaaa cgacattccc ttttgactta
    21901 gacatttttc cgtctttcat gacaaaccaa ccatgggcaa tcaaacgatc aggtaattta
    21961 acatccaaca tcataagaag gattggccag tagatagagt ggaagcgaag gatatctttt
    22021 cctaccatat ggaagactgt tccattccag aacttgtcaa agttaccatg ttcgtcttga
    22081 gcgtagccaa gagctgtcgc atagttaaga agggcatcaa tccaaacgta gacaacgtgt
    22141 tttggatttg atgggacagg cactccccat gtaaaggttg tacgagatac cgccaaatct
    22201 tccaagcctg gctcgatgaa gttgcgtagc atttcattaa ggcgaccatc tggcgtgata
    22261 aattcaggat gagctttgaa aaattcgacc aaacggtctt ggtatttgct aaggcgaagg
    22321 aagtatgatt cttcagaaac ccattcaacc tcatgacctg atggagcaat accaccagtc
    22381 acatttccag cttcatcacg gaaaacttct gccagctggc tttctgtaaa gaattcttcg
    22441 tctgatactg aataccaacc agagtattca cccaagtaga tatcatcttg agcaagtaag
    22501 cgttcaaaga cctgtgcgac aactttttca tggtagtcat cggttgtacg gataaattta
    22561 tcgtatgaga tatctagtaa ttgccagagt tctttaactc caaccgccat tccatcaaca
    22621 taggcttgag gtgtaatacc agcttcttcc gctttctgct ggattttctg accatgttca
    22681 tcaagacctg tcagataaaa tacatcgtag cccatcaggc gtttgtaacg tgctaggaca
    22741 tcacatgcga tagttgtgta ggcagaaccg atatgaagtt tcccagatgg atagtaaatc
    22801 ggcgttgtaa tataaaaatt tttttcagac ataatttttc ctttccaggc aaatgaaacc
    22861 tgtttttcta acacttcatt atatcacatt tttaatgaat ttcgataggg aaatccatac
    22921 aaaaacaaga tagacgagtg tccatcttgt tgatctcatt cataacgaag ggcttcaatt
    22981 ggatcaagtt tcgatgcctt gttggctggc aagactccaa aaatcatacc aacactagcc
    23041 gaaactgcaa gactaaatag ggcaactggg attgatactc caacttctat accttctatt
    23101 aaaccttgca gtaacaaacc tgctaaggca gttaaaccac ttgcaattgt caagccaatt
    23161 aagccaccta acaaggtcaa aatcatggat tcaatcaaaa actgaattaa aatattggca
    23221 cgtgttgcac ccaaagcctt acgaagacca atctcacgag tgcgctctgt caccgaaacc
    23281 agcatgatgt tcatgacacc agttcctcca acaaagagag aaatccctgc gatggaacta
    23341 ataatcgtcg tcataaaact aaacgattgt tgaatttctg caaatacaac ggactcatct
    23401 gccacctggt attctccctg ttgtaagcct gcaagctctg tcatttttcg tgccagttct
    23461 ggacccagag ttggggttaa actggtatca ttcactcgaa agacaatatt agctatttca
    23521 tctacattaa aattcgcagc aagggagata ttggtagtaa taggcaagcc accaaaccca
    23581 tatatttttg atcttttagc ctccggacta gtataaaccc caatgacccg gtaactaaat
    23641 ccattgactt ctacaacctt gttaatagcc tcttgaggag attcaaataa actaatggac
    23701 aattcctcat ctagcaaaat gacacttgca aactctttga aatcttgctc tctcagacta
    23761 cgacctgcaa taatttcatt cttaacagcg tccatgtaag ttctgtttcc acctgtcaaa
    23821 ttagcattct caaccttttt atcttgatag gtcaagatgg cattcgttga attggttaca
    23881 tagtaactat ccactccctt cagtttagct gcctcttgaa cccaggattc ttgcggtttt
    23941 ggcggttcaa caggaacttc ctcttccttt ccagaaaccg taaaagctga ttgtttctga
    24001 gtaaaagacc catctttact ttttttagga gagaaaaaga cgctaatatt tttctgagat
    24061 ttagtcatat ctttattgac ttgacgagat agggaatcac ccaaagccat aatcacaaca
    24121 actgatgaaa caccgataat aatcccaatc atagtaagca aagaacgcat cttgtgagcc
    24181 atgatagatg aaaaggcaaa tttcagattc tgcatcttag ttttcctcct ttcctaactg
    24241 agcactgtca gacgaaatga ccccatcccg aatgacaatc tgacgtttgg cataggcagc
    24301 aatctcaggc tcatgcgtta ccatgataat ggtttttcct tctttattca aatcaaccaa
    24361 taattgcata atttggttac ctgttttggt atccaaggct cctgtcggtt catccgctag
    24421 gataatagaa ggattgttta ccaaggcacg cgcaatggct acacgttgct tttgaccacc
    24481 agataattct gaaggtaaat ggtgactacg ttctgtcaat tcaaccttgt ctaaatattc
    24541 ctcagccaac ttgcgacgtt ttgaagacga aactcctgcg taaatcaagg gcaattctac
    24601 attttgcaga gcattgagct tcgatagaag aaagaactgc tgaaagacaa aaccgatttg
    24661 ttggttacgg accttagcca gttgtttttc accaagccca gccacttctt gaccttcaag
    24721 ataatattct ccactggttg gtgtatccaa catgccaatc gtattcatca gagtggactt
    24781 accagaccca gatggtccca tgatggctac aaattcaccc tcattcactt ctagattgat
    24841 atttttgaga acctgcaatt cttggtcacc attacggtag cttctgaaga tattttttag
    24901 actaattagt tgcttcatca gccttcacct cttttccttc ttccaaggaa gatgttggat
    24961 tactgatgac cttagcaccg ttcgttaaac cagaagtgat ttcttgattt tctgcgtcag
    25021 catttcccaa tgaaacctca acttttttag ccttttgttg ttcatccaca atccagacat
    25081 aatttttact atcatccatt actagactgc taacaggaac aagaatagcc ttagttttgc
    25141 ttttaacctc aatgttgaca gaaaaacctt gtttcaaatc accaacctcg cctgtcacat
    25201 caatagtata agggtattta gaacctgtat tattcccggc tgctggacta gctgcttcac
    25261 cattgttttt aggatagtca gaaatatagc ttaatttccc agtccatttt ttatcaggat
    25321 acactttaga agtaaagctt acttcttgac ctacagaaag gttggctaga ttgtactcag
    25381 acaattctcc cttgacttgt aaattttcat tgctgacaat atgaaccata acttggctcg
    25441 cccctgttgg agatttagaa acattgctat tgacttcgac tacagttccc tctagggtac
    25501 tgagaacagt tgttgcatcc aattgacttt gagccttact taattgcgcc gcagcatctg
    25561 cacgcgcatc acgggcatca cccaattgag cgtcaataga agcaacagaa tttccagcca
    25621 ctggagttgg gctttgcacc gttgcatctt ctcctcctac tggcgctggt aactgtggag
    25681 ccggagctga agcggcttca tttcgtgctt gattgagttc attgatatga cgatctgcct
    25741 tagctactgc tcgactagct gaatcatagg ccgcctgcgc ttctgaacta ctgtacttga
    25801 ctaaagcctg cccttcgctg accttatcgc ccacagaaac aaggatttca tctaaatcac
    25861 ccttactagc atcaaaataa acatattgtt cattttttgc tgttactgtc cctgacaata
    25921 aaacagagga tgccacgctt ccttccttgg caacaacaag atgagtaggc tcatctttta
    25981 gagcagtctg agaaggttgt ctaaagagta aaatcccccc ggcacccaat acaactacac
    26041 tcgcagcacc gattgctgca tacagttgcc actttttagc tttaccattc tttttcttca
    26101 taatgaaact ccttttcttt tttacaatac tttgctatta taccaaattt ccctccagca
    26161 aacaatgcag ttcagatgga aataatggca gttcaggatt aaacaatcgt tcggaatttt
    26221 gcttttctat tgtactagat atataataca ctatcttgac ttatttggca agcttttttg
    26281 caattttttg tgcgtagcag atttttgcaa tcaaatcaaa aaaagaataa aatataacta
    26341 tcaaaaaaga cactctacta tttaaaagat tacaaaggag ttttcaatga gagaatatga
    26401 tatcattgct atcggtggag gtagcggagg aatcgctacc atgaaccgtg ctggtgaaca
    26461 tggagccaaa gcagccgtta ttgaggaaaa gaaattaggt ggaacctgtg tcaacgtcgg
    26521 ttgtgttcct aaaaaaatca tgtggtacgg ggcgcaaatc gctgagactt tccatcaatt
    26581 tggagaagac tacggcttta agactactga tcttaacttt aactttgcaa ccctacgtcg
    26641 caatcgtgaa gcctacattg atcgcgctcg ttcttcttat gatggtagtt ttaaacgcaa
    26701 cggtgtagac ttgattgaag gtcatgctga atttgtagat tctcatactg taagcgtaaa
    26761 tggtgaactg attcgtgcta aacatatcgt gattgctaca ggtgcccatc caagtattcc
    26821 taatattcct ggtgctgagc taggtggctc ttctgatgat gtatttgcct gggaagaact
    26881 tccagagtca attgccattc taggcgctgg ttatatcgcc gttgaattag ctggcgtact
    26941 ccacactttt ggtgtcaaga cagatctctt tgttcgccgc gatcgtcctt tacgtggttt
    27001 tgattcctac atcgttgaag gtttggtcaa ggaaatggaa agaacaaact taccacttca
    27061 cactcacaaa gtccctgtca agttagaaaa aactactgac ggcattacca ttcatttcga
    27121 agatggtact agtcacacag ctagccaagt tatctgggct acaggtcgcc gtccaaacgt
    27181 taagggcttg caacttgaaa aagctggagt gactctgaac gaacgtggct ttatccaagt
    27241 ggatgaatac caaaatactg ttgttgaggg aatctatgct ctaggtgatg taacgggcga
    27301 gaaagaactg actccagttg caatcaaggc cggacgtacc ctatctgaac gtctctttaa
    27361 cggaaaaact actgcaaaaa tggattactc aactattcca actgttgtct tttcacaccc
    27421 tgctatcgga actgttggtt tgacagaaga gcaagctatt aaagaatacg gtcaagacca
    27481 aatcaaggtt tataaatcaa gctttgcatc tatgtactct gcttgcactc gcaaccgtca
    27541 agaatcccgt ttcaaactca taacagctgg ttcagaagaa aaagttgtcg gacttcatgg
    27601 aattggctac ggcgttgatg aaatgattca gggatttgcc gttgctatca aaatgggagc
    27661 aaccaaggct gactttgatg caactgtggc aattcaccca actgcatctg aagaatttgt
    27721 aaccatgcgt taatcgaaac aaaagaagct gatataaata tgtctgcttc ttttttaatg
    27781 attttcgaat caacaaaaaa attatccaac ttgactagtc acgaaaatcg gctgttacag
    27841 tttttgttac cttgttttta aaaaatggtt gacatcgact cctatatgag tataatagtt
    27901 actatacatt agaaaagagg ttaactattt tgaaaaaagc tcacgtttat gctatccctg
    27961 ctattggggc tgctctcatt gctgttttgg cacaaatcag tcttccaatt ggacctgttc
    28021 ccttcactct gcaaaacttt gcaatcggct tgattgctac tgtctttaga ccgagagagg
    28081 ctgtactttc tgctggactc tatcttcttc taggtgctat cggtcttcct gtctttgcag
    28141 gaggtggagc tggttttcag gctttagttg gccctactgc aggctatctt tggttttatc
    28201 tcgtttactc tggacttact tcctctctaa ccaacagcaa gagtggtgtt gttaagattt
    28261 ttcttgcaaa cctcttgggt gatgcccttg tctttgtcgg cgggattctc agcttgcatt
    28321 tcctagctgg aatggcattt gaaaaagctc ttgttgtggg ggttcttccc tttatcattc
    28381 cagaccttgg caaacttctg gctattagtt ttattagccg tcccctactt caacgcctta
    28441 aaaatcaggc ttactttact aactaaaaaa ggataccgag ttatcatgac tcaatatcct
    28501 tttttttatt ttgaaaactt atactcaatg aaaatcaaag agcaaactag gaagctagcc
    28561 gcaggctgct caaaacactg ttttgaggtt gtagatgaaa ctgacgaagt cagtaaccat
    28621 acggcaaggc aaagctgatg cggtttgaag agattttcga agagtattag ttgcctttaa
    28681 aggcatccac catcgtttga aattcttcat ttgagagagt aatccctttg cccattttag
    28741 tatggtctgg actccaagca cgaatatcaa actttgcagg ggcaccatta aagctcacac
    28801 ggttaatttc cttggtccaa cctttttcgt tttcagaaag agtcaacaag tgctcttcga
    28861 tttcaaatgt aaattctgcc attttcttct ccttttttag tttcattagt ttattcgtaa
    28921 aatcttgtag attttaggaa aattttatat aatattgata taaaagaagg gaggccaata
    28981 tgagacataa attccagcaa gttctagata aaatacatga ttttttaaat ggacatgacc
    29041 aacctgacca gactgaaacc aactccctta cagccactat tgaagaggct atccagaaac
    29101 aaaccgctgt tcaccttatc ttgtctgaga caagctttac aggtgatatc atcaaatatg
    29161 atcagcaagg ccagcaaatt atcgtgaaaa attttgccaa aaatgtgagc cggattatcc
    29221 gtataagcga tattcaacgc ctgcgatttg tcccctcaac tgtccaaaca gcccaaaaaa
    29281 atagatttaa gaaagagtga gatgtagttg cttcatccca ctcttttttc ttagcgaatt
    29341 tgttcaaaat gtaaatgaac tgcgatatga tctccataac cacttctttc caagtcacgt
    29401 tgtaaacgat aggaaatgta gtgttctgca atggtaatgt aacctgcgcc caataaacga
    29461 tgttcaacca tagattgaat catactgata gtcgcacgtt ccaccttggc ttcttgtaaa
    29521 tccaaaacta ccttcttagt gacttgagca agattttgac gcaaatcatc tgtcaaaaca
    29581 taaacagttt gggctgcctt caagatggct tggtaaatct tatctggatt aaattcagca
    29641 atttcgccat tacgtttgat tacttgcata ggtttctcct ttattctttg ttttctttga
    29701 tttctgccag cattttttct tcttctactg tcagttgata atgttcaagt aaatccggtc
    29761 tgcgctcgta ggttttcttt aaactctcgt acaatcgcca ctgacgaatc ttttcatggt
    29821 ggccactcat caatacatct ggcacgacca tgcctcgata atcataggga cgtgtgtact
    29881 gaggatattc taaaagacct gaagaaaaac tatcatcttg gtggctagac tccttgccaa
    29941 tcacttctgg aatcaggcga actgtagcat caatcatggt catagctgcc aattctccac
    30001 cagtgaggac atagtcgcct agggaaatct catctgttac caaggtctta atgcgctcat
    30061 cataaccctc atagtgccca cagataaaga ttagctcttc ctcttgagcc aaatcttcag
    30121 cataagcctg atcaaactgc tttccagcag gatcgaggag aataacgcgc ggatttttct
    30181 tttcaatagc atcaaaggaa tcgaaaatag gttgtgctct gagcaacatg ccctgaccgc
    30241 ctccgtaggg ctcatcatct acatgacggg ccttttcagc attttctcga aaattatgat
    30301 actggatatc caagagccct ttttctcgag cctttccaac gattgagtgc tccagtggag
    30361 aaaacatctc tggaaagagg gttaaaatat caatcttcat cgtctaaccc ttctaagatt
    30421 tccacatcga cccgtttatt tggaatatca acattgagaa ccactggtgg gatataaggt
    30481 aaaagcaaat cacgtttgcc ttttcgtttg accacccaga catcattagc acctggttgc
    30541 aggatttcct tgatggttcc aaccaagcta tcaccctcat agacttccaa accgataatc
    30601 tcgtgatagt aaaattcacc atcgtctagg tcattcaaat cttcctcagc gaccttgaga
    30661 ctgtatccct tgtacttttc gatagtattg atatggtaca tatctttgaa tttaataatg
    30721 tcaaagttct tctgtttacg gtggctagcg atggtcactg tttggacaaa ctgatctttt
    30781 tcatcaaaca aagtcagctc agctcctttt ttaaaccgtt cttctgcaaa atccgtcaca
    30841 gacaatactc gcatctcacc ctgtaatccc tgcgtattaa cgattttccc aacattaaag
    30901 tagttcatct tgtctcctgt aatctccttt ttccatctta ttctgacaat tctcgaataa
    30961 tagccgcaat tttttccgat tctgaccatt gtaaataatg gtgattcctt cctaaaatga
    31021 gtttagtatt ggaagtccaa tattctgatt ctctgtactc tttttctcta taagtctgac
    31081 aaaaaataaa tacagggaca tgagattcta tcgacaaatt ctcaaaatct tcctcagtaa
    31141 tctctccaga tatctgaaat tctggatctt gattttccaa ctctaagcct ttttcttgca
    31201 ttaattccca gattttttta ttcgtttcag gactaaatgt tgcttgagtt aagttcttaa
    31261 aataaagttc aggaccacac tcgtcaatca gcctcatctg ctcttccatt tctggataag
    31321 gattttctga aaaatcagca aacatgactt ttttagttgt cggttcaatt gctactaaag
    31381 tctgacactt aattggtttc tcgagtaatt tgcaagctaa aattccactc caactatgtg
    31441 cacaaagtat atattcagaa attcctaatt cttcaagtac ttcataaacc gcatctgcaa
    31501 gattatctag attttttcca gcttggtcat gaatcggact cctacctgtg ttcggaaaat
    31561 caattgtcaa ataaccaatt gtaggaggag gtttttcaag tataagtgaa aaattttcat
    31621 aacttggtag caaacctgct ccgtttagac aaactagcac tttcttttgc tttttataag
    31681 taacagagag gctaccaatt tctgtagata cttcaaacct cttcataaag aaatccactc
    31741 attctatata atgaattatt aaaaatcctt atcctttatt ttatcacgtt ccaaagattt
    31801 tctcaagttg gaggaagggg acaatatctc tactttccct tcaagaatcc ttccaaatca
    31861 tgtttatgtt ggtaattaac ggctgcggtt ttgtctttct caaagatggt tctagttagg
    31921 tcaatatgct tgatagcagc aatagcgacg gtgtagtgaa tgatattagc cagttctatg
    31981 gcaggttcct cgttcgaatc ctatcccttc ttttcgacca gagcgcctat tcaaaacctc
    32041 ggctacttct ccgacttcct ccactaactt cataaagaga ccttcatcag tccgagactg
    32101 ctgttaatgt tcgagtaagt agtcttggaa ttgcctaaac gttcaatctt ttatagtata
    32161 ttgaaactag aatagtacac ctttacttct aaaacattgt tagaaatcga tttgactgtc
    32221 ctgatcgatt tgtcctgtta ttatttcatt ttactatatc ttctattcca cacaaaaaag
    32281 cgagacatcc gtcccgccct tcttattttt cgtcaataac gattcttact tttttgtatt
    32341 cagttgggac agagtagaca atcgttctta tcgcagaaat agtgcgaccc ttacgaccga
    32401 ttacacgacc cacatcgctt tgatcaagat tcaaatgata ttccaaaaat tctggtgtat
    32461 cctcaatctt gatagttaag gcatctggtt gtgaaattaa gggtttcaca atcgcaataa
    32521 tgagattttc aatcgtatcc atctgtcaac ctactttaaa cttattttga gaatttagaa
    32581 tcgtggaatt ttttcaatac gccttctttt gaaaggatgt tacgtactgt gtctgaaggt
    32641 tgagctccat tagccaacca tgcaagaacg cggtcttctt tcaaagttac ttggttttca
    32701 gcaacaagtg ggttgtaagt tccaactgtt tcgatgaaac gtccgtcacg tggtgaacgt
    32761 gaatctgcta cgttgatacg gtagaaaggt tttttcttag aacccatacg agtcaaacgg
    32821 attttaactg ccatttttaa agtctcattt ctttaatttt ttatttcggt gaaatagctg
    32881 agctatttag cacatgttct attatagcag atttctggca ggtgtcaaga aaaaaacttg
    32941 acagactata aatttcttaa agcatttaga aatttgttag aataggaaat aaatgtttga
    33001 aagatgctat ccgtgaatac tattttagaa aaattttata aagaacacca agtcaaaccc
    33061 ttcatatcgc ctgaacgaga tttggatact tggcttctaa gtcccaaacc cgttcccaag
    33121 cgaaatatgg acttattagc agatgattca ctagcaggag atatcatttt actatggaga
    33181 atccagtttg gtacttttac cactgaaaca tgattttaaa aactcccatt cgaatatgat
    33241 tcaaaattcg cttagaatca atgttttccc actttttcaa aaaataaatt ttcatctaat
    33301 ttaaataact ttcaattaag tgtgaatttt gcttaaaatc attaaaaaac accccatggt
    33361 gtgaaccatg aagtgttgta aatgctgtgt tgtagctagt tcttagcgtt tagagaactg
    33421 gctagcttta cgagctttct taagatctgg ttccctaaat actttgagta cacttatggc
    33481 attgatgccc caaaacatct aaaaactctg gtagaaaaag ggtatgctct tgtcgaaact
    33541 tcttttgact cacttgacca tctaaataat accatgaaaa agaatatcct gaagaagaag
    33601 aagggagtta ctggactttc taaaatgaaa tcttgcgacc tggatcaagc ccttcatgag
    33661 catttttcag aagaagaatt agctggtcac tttcatgtcc ttctatggac ttttttacaa
    33721 tggcattgct atcacaccca atacctatct aagcgcctgg ttcgtaaact ttattgcagc
    33781 tcttcctcta aatttcctaa ttgttgaacc aattgcccgt tttatactaa gttcttttca
    33841 gaaaccattt actggggaag aagttgaaga ttttcaagat gatgatgaaa tcccaactat
    33901 tatctaagcc agttctgtaa actactaata tttgaaatcc acttcctttt agggtacaat
    33961 ggttataaat gaatttttga gaggatcaga atgaaaaaac tagcaaccct tcttttactg
    34021 tctactgtag ccctagctgg gtgtagcagc gtccaacgca gtctgcgtgg tgatgattat
    34081 gttgattcca gtcttgctgc tgaagaaagt tccaaagtag ctgcccaatc tgccaaggag
    34141 ttaaacgatg ctttaacaaa cgaaaacgcc aatttcccac aactatctaa ggaagttgct
    34201 gaagatgaag ccgaagtgat tctccacaca agccaaggtg atattcgcat taaactcttc
    34261 cctaaactcg ctcctctagc ggttgaaaat ttcctcactc acgccaaaga aggctactat
    34321 aacggtatta ccttccaccg tgtcatcgat ggctttatgg tccaaactgg agatccaaaa
    34381 gggaacggta caggtggtca gtccatctgg catgacaagg ataagactaa agacaaagga
    34441 actggtttca agaacgagat tactccttat ttgtataaca tccgtggtgc tcttgctatg
    34501 gctaatactg gtcaaccaaa caccaatggc agccagttct tcatcaacca aaactctaca
    34561 gatacctctt ctaaactccc tacaagcaag tatccacaga aaattatcga agcctacaaa
    34621 gaaggtggaa accctagtct agatggcaaa cacccagtct ttggtcaagt gattgacggt
    34681 atggatgttg tggataagat tgctaaggcc gaaaaagatg aaaaagacaa gccaactact
    34741 gctatcacaa tcgacagcat cgaagtggtg aaagactacg attttaaatc ttaaaaacca
    34801 aaaaaataca gtatccacat tcggtactgt atttctttta ctctcattct taagttaaat
    34861 tattaaaatc ccatatttgg tctatccagc cttcataaaa gtctggctcg tggcagacca
    34921 taaggataga tcccctatat tctttgagag cgcgtttgag ctcatccttt gcatccacat
    34981 ccaaatggtt ggtcggctcg tccagcacta aaacgttgtt ttcacgattc atcaagagac
    35041 agaaacgaac cttggcttgc tctccccctg ataatacttg aatctggctt tcaatatgtt
    35101 tggttgtcaa accacaacgg gcaagggctg cacggacttc tgcttgatta agggcaggaa
    35161 aggcattcca gacagcttca agaggagttt ggcgattacc gccttctact tcctgctcaa
    35221 aataaccaag ttctaaataa tctccacgct ccacttcccc agcgattggc gagataatgc
    35281 ctaagagact cttcaagaga gttgtttttc caataccatt agcaccaata atcgcaacct
    35341 tttgattgcg ttcgaaggta agatttaaag gcttagtaag aggacggtcg taaccaattt
    35401 gcaagttctt ggcttggaag ataaagcgcc ctggtgtacg agctggtttg aaatcaaagg
    35461 atggttttgg tttctcactt tggagttcga taatatccat cttatccaat ttcttttgac
    35521 gagacatagc catattacga gttgcaacac gggctttatt acgagccaca aagtccttga
    35581 ggtctgcaat ctctttctgc tggcgttcgt aggctgcctc tagctgagat ttcttcatag
    35641 cataaacttc ttggaactgg tagtagtcac cagagtaacg cgtcagctgt tgattttcca
    35701 catgatagac aatattaata acgtcattga ggaatggaat atcgtgcgaa atgagaacaa
    35761 aggcattctc atagttttgg agatagcgct tgagccaatc aatatgctca gcatccaagt
    35821 agttggtcgg ctcgtccaac agcaagatat caggcttttc aaggagaagt tttgccaaaa
    35881 gcaccttggt tctttgccca cctgacaaag aagttacatc cgtatccatg ccaaagtcca
    35941 taacaccaag agcacgcgct acttcgtcaa tcttagcatc caaggtatag aaatcacgac
    36001 tctccagacg gtcttgaagt tctcctactt cttccatgag agcatcaaca tccgcgccgt
    36061 cttcagccat tttcatatag aggtcattga tacgagcttc agctttaaaa agctcatcaa
    36121 aagccgtacg gagaacatca cgcaccgact gtctttcagc aaggacagag tgctgatcca
    36181 agtaaccagc cgtcacatat ttggaccact caacctttcc ttcatctggc agcattttac
    36241 cagtcacgat actcataaag gttgattttc cttcaccatt ggcaccgacc aggccgatat
    36301 gttctccctt gaggagacgg aaggacacat cttcaaaaat tgcacggtca ccaaaaccgt
    36361 gactcagatt tttaacttct aaaatactca ttttaattcc ttatcttgtt tttatgtaat
    36421 cgtttataaa ggagccaagc cagatagcca cccaaagtgt tggtccacaa atcatcaatc
    36481 tcaaagacgc gattgaaatc aaagaaaaag tccaagatta attgcgtaca ctcgattcca
    36541 agactcacaa gaaaactaaa aagaaggacc ttttttgttt tccgcaaatt tggaaataga
    36601 taaaggagtt ggaaaatcag aggaaaaaac aagaagacat tgaggacatt ttgtaaaaaa
    36661 atccaacata attgtccaat gtcactcact tcgcccagtt tccagagaga attgaaagga
    36721 gtcaaaagaa aaaccaggcg tccaagatgc tgaatacctg gagttcccac tcccacggta
    36781 gattgttctt gaggagtaaa gcaaaaacag acaatgcaaa tgctatagaa aatgactccc
    36841 cagaccaaaa tatgattata agtcttcttc atcattaagg atttaccgct gcgactgcct
    36901 tctggcggtc acgtttcatt gtgttagagc gcaattgtcc acaagctgcg tcaatatctg
    36961 taccatgctc ttgacgaacc acacagttga cccctttttt cttaagcgta tcatagaaag
    37021 ccaacacgcg ctctttggga ctacggctat attggtcatg ctcactaact gggttataag
    37081 gaatcaagtt tacataagac aatttcttga tgttcttgag caattcagtc aattccaagg
    37141 cttgttctac actgtcgttg acttcattaa gcatgatata ttcaaaggtt acacgacggt
    37201 ttgttgtctc aatgtagtat tcaatagcag caaagagttt ttcaatcgga aaggcacggt
    37261 taatcttcat gatacttgaa cgaagttcat tgttaggtgc gtgaagagac acggcaagat
    37321 tgacctgaac cccttcatca gcaaagtcac gaattttatg agccaaacct aaggttgaaa
    37381 ccgtgatgtg acgagcaccg atagtcattc ctttatcatc attgatagta cgaaagaaat
    37441 tcaagacatt gttgtaatta tcaaagggct caccgattcc catgacaacg atatggctga
    37501 cgcgttcatc ctgaccacgc tcatcaaagt atttctgaac cagcatgatt tgcgctacga
    37561 tttcaccgtt attgaggtca cgttgcttct taatcaaacc agaggcacag aaggtacaac
    37621 cgatattaca gccgacctga gtggtcacac agacagataa accatagtgt tgacgcatga
    37681 gtacagtctc aattaacata ccgtcgggca attcaaagag atatttgact gtaccatcag
    37741 cagactcttg cacaatacgt tgtttcaagg gattgaccac aaactggtca ttgagcttag
    37801 caatcaaatc cttggaaagg ttggtcattt cttcaaatga ctgcacacgt ttacggtaga
    37861 gccattccca gatttgatct gcacggaatt tcttttctcc ctgctccaat acccattcct
    37921 gcatggtttg atgtgccaaa ctatgaattg agggtttcat ttcttctcct tattctctac
    37981 tcacttctga cgaatgacaa aatgacgttg tcccttgtcc tctttctgag aatgctggtc
    38041 tttctgacga cgtctattct tcttatctgc attcgacttt cgtttagttt gagtcggttt
    38101 ctttcctttt ctagaaggtg tttcttcttc cgtcttacgc attttcttgt caaatgatgc
    38161 tcgcttaggg gcttcatttt ctaagacaaa ataggcacaa ccataactac aatactctaa
    38221 aaggtagtct tgtaaacgac tgattttttc aagtttttct tctgttcggt catccttgta
    38281 aaaacctcgt aggcgaagct gttcgttgct ccagtccccc acgatataat caaacttggt
    38341 taatacttct gaaaaacgct gattaaaagt cgtcacatca aaggcatcct tgatattttc
    38401 aaccaaggaa aaagctatcc cttccgtttc gaccttgtcc ccgtgtaaat ggaactccgg
    38461 accaggaaac ttgttatagt tgtataattc aggtgcaatt tcttttcgca tagatatcct
    38521 ttttccacga ttacttaata ctttattcta ccataatttc tagcagttag cacgtttctc
    38581 ataaaaatga aaaaagtctg acgattttgt cagaccagaa tcttataacc taaaaagaga
    38641 agaacaattc ttccctccaa ctatcattat ttagcagctg cgtacaattc atctacttta
    38701 ttccagttga ttactgaaaa gaaagctttg atgtagtcag gacgcacgtt gcggtatttc
    38761 acgtagtaag catgttccca aacgtccaag cccaagattg gttttttacc ttctgagatt
    38821 ggtgtgtctt ggtttgctgt tgaagtcact tcaagtttcc cttctttgtt gacaaccaac
    38881 catgcccaac ctgaaccaaa acgagttgtt gctgctgcag tgaaggctgc ttggaattct
    38941 tcaaatgaac caaatgttgc atcgattgct gctgccagtt ctgctgaagg agctgttttc
    39001 tcgggagtca tcaattccca gaaaagagcg tggttcaagt gtccgccacc attgttgata
    39061 agtgcttgac ggatatcagc tgggatagat tctacatcag caagcaaggc ttcaaggtct
    39121 tcaccgattt cagggtgttt ttctaaagct gcattggcat tgttgacata agtttgatgg
    39181 tgtttgtcat ggtgcaaatg cattgtttcc gcatcgatgt atggttccaa agcgtcgtat
    39241 gcatatggaa gttctggtaa gataatagcc atctgtaata cctctttttc tttctatatg
    39301 aaaatgataa cgcaaacatt cacttttttc aagttttttg cttatagata aggaaatcac
    39361 tgacatactt tctaataaaa taagcaaatc agcaagaaac ccacgacaag ataatcctga
    39421 cgcgggttgt agtttcaaca aatgtcaatt gacctgacta gcaatctgta agagtgcctt
    39481 ttcaaaaagg aaaccttttt cataaagacc tgtcttaatc tgatagtctg tctcaatcaa
    39541 ataggaaata gcttgcttca gaaagctcaa agaaagtcct ctcgaatctc ttaatgcaaa
    39601 cttgatttga taaggatttg ggttacgtcc cagataacta cctaaactac ttgcaatctg
    39661 cgattctgtt tggccagact ccgccaaaat cttcacctga gtaaaagtcc gaaattgtcc
    39721 cagcatgact gcaatcagtt tgatttcatc ttccccttgc aaggtcaagt ctctcaccaa
    39781 atcgcgcgcc tgatccatct ttttagtcag aataaactga gttaaatcaa aaatattgtc
    39841 ctgcaaggtc ttgggaattg cgttaacaat atcctcttcc tcgataacag aatccgcctt
    39901 ataggactgt aaaaagagaa gatttttctg gatttcgcta aattgaaacc ccgacttgat
    39961 gaggagattt tcaaaagaat gattggtaaa ctgcagacct tgtttctgac tccacttttg
    40021 gaaatactgg cgcaattctt gttcttttac ttctactgca tcgaagacct tggcatcacg
    40081 cttaagtaat ttgactaacc gtcttttgct atccagcttt ccttctgcaa agattatcaa
    40141 cttggttgtt ggagaaggat tgtcaaggta ttcctcaaat gacttaagct catcatctgt
    40201 caaaaagcgt ttcttagcag tcgtgatatc cataaaataa tctaatatca cgattttctc
    40261 atccgcaaag aaaggaaggc tgaccaactc cagttccaca tccttgtaaa ctacttcttt
    40321 catatcaaag taggcaaagt tgaggtcagc agaatcatac ccaatctgtt tcaacacttg
    40381 actcttcatc acttcaaact gaccctgatc tgtccctgta aataggctca ggctcggtaa
    40441 atttgataaa gtcaacttct gactttcttc aatggctagc atcgtctctc ctttcttcag
    40501 atttttcgat ttaatttagt caatatagcg caatttccca cggaaatctt ctaagctctc
    40561 gtagcctttt tccaccatga ttgctttcag ttcattggta atgcggtcaa aagcactgac
    40621 gccttctttg tgaagggtcg ttcccacctg caccatactt gctccacaga ggatgtgttc
    40681 aaaggcatct cgaccagtca gaacgccacc tgttccgata atttggattt gaggatttaa
    40741 acgttgataa aaggcgtgaa cattggctag agcagtcggt ttgatgtatt ctccaccaat
    40801 tccaccaaaa ccattcttag gccgaataac gacagattcg tcttctatat agaggccgtt
    40861 tccgatagag ttaacgcagt tgacaaactt gagcggatat ttgttgaaaa tagctgccgc
    40921 ttgatcaaag tgaacaatat caaaataagg tggcaattta attccaagag gtttggtgaa
    40981 gtaagcaaac acttctgcca aaatccggtc tgttgtctca aaatcatagg caatctgagg
    41041 tttacctgga acatttggac aggaaagatt tagctcagtc agaccacgaa aatcactctc
    41101 ttggactttt ttcaaaatag tatgggtttc ctctggagac atgccgacca gagataagaa
    41161 gaaagttcgg ttcgactctt tttcctgcaa atctaaaaga taatccaaat aatagtctaa
    41221 gccattattt ggcaagccca tagagttgat ggaaccaagt ggaacatctt ggtagcgtgg
    41281 ctcaggattc ccctgacgga agtccaaggt cgctgtctta gtaacaaagg ttcctgccgc
    41341 tgagtttttg acctcttcta actcctctat cgtcatacaa gccacacctg ctgcattcat
    41401 caagcaattg tcaaactcaa aaccagcaat ttgtgttttc gttgatacca tgattctaat
    41461 cctccagatt tcttttattg ctaatattat accataattt taattctagg tttactagat
    41521 tctgtggttc tatctattta ttcggaaaag aaagtctagt acagaagtca tgctatggaa
    41581 acagctagtg tattagaagt ttgaacaagg cttgggtaac agacttttga atgaagtcca
    41641 agcaacaagg agaaatctca accatgagtc cattccatga ctctgttgct ctagaaaacc
    41701 ttgcaatagt caagtgataa cgaataaaac tttggattga aatatcccca agattatcta
    41761 ttacgaggag aaatcttaac ctttatcatt tttaaagaaa tatagtaaaa tgaaacaaga
    41821 acaggagaaa tcgatcagga cagtcaaatt gattgctaac aatgttttag aagttgaggt
    41881 gtactattct agtttcaatc tactatacat gtaaatctct actttcgcaa aatggatttt
    41941 cagaacagta tcccagtata gttaaaaact ataaaaaaga gaggacgttc ccctcttaaa
    42001 atcttatttt actgcttctt tcaaagcatc taccttatcc aaacgttccc atggaagatc
    42061 aatatctgta cgtcccatgt gaccgtaagc cgatgtttga cggtaaattg gacgcttgag
    42121 gtccagcatt tggataatcc ctgcagggcg aaggtcaaag atttgacgag ccgctttttc
    42181 aagttgactt tcagctactg ttcctgtacc gaaagtatcg atacgaacag aaacaggttg
    42241 cgcaacaccg atagcatagg ccaactgcac ttctgccttc ttagcaaggc ctgctgcaac
    42301 gatattcttg gcaatatagc gagccgcata agaggctgaa cgatccacct tagtcgcatc
    42361 tttaccagag aaggcaccac caccatgacg agagtagcca ccataagtat ctacaataat
    42421 cttacgacca gtcaaacctg agtccccttg aggaccaccg attacaaaac gacctgtcgg
    42481 attgataaag aattttgtct tatcatcaag ataagaagat ggaataactt ctttgatgac
    42541 cttgtcaatc acatcttgat ggatttgttc attagtggcc tctggatcat gctgagtaga
    42601 aataacgact gtatctacat gtaccggacg gtcattttca tcgtactcaa ctgtaacttg
    42661 tgattttgca tctggacgga gatagctaat ttctccagac ttacgaagtt ctgccagacg
    42721 acgaaccaat ttatgactga gtgcaattgg caatggcata agctcttctg tttcatctac
    42781 tgcaaatcca aacatgagcc cttggtcacc tgctccaatc aagtccagtg gatcttgatc
    42841 agcatttcca cgaacctcca aggcttcgtt aacaccttga gcgatgtcag gagattgttc
    42901 caccaaagat gggtgtactc ccaccgtctc agcagaaaat ccatattctg tattggtata
    42961 accaatctct gcaatggtat cacgaaccac acggttaata tccacatagg catttgtaga
    43021 aatttcacca aaaacgtgga cagaaccagt atatacagct gtttcagcag caacgtgcgc
    43081 ctctggatcc tttgctaaaa tagcatccaa aatcgcatct gaaatttggt ctgcaatctt
    43141 atccggatgc ccctcagata cagattcaga cgtgaataat ttacgttctg acataaaaat
    43201 gtcccccctt aaaaaatatt gttatagagt tacaaagtac tgataggaaa actcttcgta
    43261 ataaatacct accatcttat cgggactata taactttatc attataccat ttttaatcgc
    43321 aatttgcagt ctttaatgta gtgtttcggt ttagatagtt cgttctcata aagcaaaaag
    43381 ttggagctca gtactccaac aatttctatt aaaatgtttg acgtttagct ttacgctctg
    43441 cacgaccgcg agcgcgattt tcagcacgct tggttttacg gcgcttttca tcaaccgccc
    43501 attgaatttt cttcttataa cccggtttga cttttttctt tttcttttta accaaaccaa
    43561 tcatttcgat atcaagttta tcttgttttt tctcacggtt ggcacgacga tcacggtcat
    43621 aggtatcttg aaattccccg tctttgacca tcttaggact aaacttgatt cccaatttct
    43681 ccaactcacg gatatccgag tcatcacttg gctgataaag ggtaatagct gtacctggta
    43741 ggccatttcg tccagtacga ccaacacggt gaacaaaaaa agataagtct tgcggaatgg
    43801 catcattgat gacatggctg acaccttcaa tgtcaatccc acgtgctgcc aaatctgttg
    43861 cgacaatata ctcaaaatcc agattttgca cctgattcat gattcgcttg cgttcacgag
    43921 gggcaatatc gccatggatt tttgcaacct tcaagccttg agcagtcaga tatgaatgca
    43981 attcatcagc acgcgtttta gtgttaacaa aaatcattgc caaatacggc tgcatcaact
    44041 gagtcaactg gtaaatttga gcattcttat catgtccctt ggtcgaaatc aaccaattat
    44101 caatggtgtc agaaataacc gttttggtct taattttctc cataacagga ttggataagt
    44161 attttttcaa gaatggttgc agtttttgtg ggatagtcgc tgagaagacc atgaattgca
    44221 agtcttttgg aagactgcca gcaatcttat caacagtttc caagaatccc atatccaagg
    44281 tcatatccgc ttcatcaaca acaaatgtct tggctttatg aatagctaaa tcaccagatt
    44341 taaccaagtc gtagatacgg cctggtgttc caataacaat atgaggctga ttgcttgcca
    44401 atttctcaat ctggcgagcc ttatccgtac cacccacata attaaccaca cgaacttcga
    44461 catctgagtg agctgaaatc tgacgcgcta cttggtaaat ttgagtagcc aactcacgac
    44521 tcggtgcagt aatcactgct tgtacactat cgctagcttc atctaattgc tggaaaatcg
    44581 gtaacaagaa agtatgagtc ttacctgaac ctgtttttga ttctcctact aggtcacgac
    44641 ctgccaaaac aataggaatc aacttatctt gcacctctgt tggagttgta aattttaact
    44701 cctccaaggc ttctctaata tagtttttaa attgaaattt cgtaaatgac ataacatcct
    44761 cgattctatc tatcttatca attataccat attttattcc attacagtag tctcacttat
    44821 ttaggctatt tccagtagct tctctagtaa gaaaaggctg gaatttta
//
LOCUS       DBMVGT010000010        44731 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.010, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000010 DBMVGT010000000
VERSION     DBMVGT010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 44731)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 44731)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..44731
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.010"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(40..750)
                     /locus_tag="AC0DU4_000579"
     CDS             complement(40..750)
                     /locus_tag="AC0DU4_000579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000127555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HIN4236581.1"
                     /translation="MTATSLGLSNIEIVVRIVLSVVIGSIIGLERGSKSQPAGIRTYS
                     IVCLAACLIMMTNEYVSYKFGTGDPTRLGAQVISGVGFLGAGTILITDKKKITGLTTA
                     AGIWASAGIGLAIGVGFYEGALLVAISVWGVISMFQPLKKYLQNRSKMIELYIVVKST
                     EAYNRVLVYCAENGIRMTDSRTAFGDVNSDRIEYFDVPDKKIASFITLELSGRFEHLR
                     LMEEIANIVGVIYVEEIS"
     gene            complement(753..2444)
                     /locus_tag="AC0DU4_000580"
     CDS             complement(753..2444)
                     /locus_tag="AC0DU4_000580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236582.1"
                     /translation="MRHKLNLKDWLIRLGLIWFLVTFIIYPNFDLVVNVFVKGGEFSL
                     DAVHRVLKSQRALQSIMNSFKLAFSLIITVNVVGILCVLFTEYFDIKGAKILKLGYMT
                     SLIYGGVVLATGYKFVYGPYGLITKFLQNVIPSLDPNWFIGYGAVLFIMTFSGTANHT
                     LFLTNTIRSVDYHTIEAARNMGAKPFTVFRKVVLPTLIPTLFALTIMVFLSGLSAVAA
                     PMIVGGKEFQTINPMIITFAGMGNSRDLAALLAIILGIATTILLTIMNKIEKGGNYIS
                     ISKTKAPLKKQKIASKPWNIIAHIVAYGLFTVFMLPLIFIVLYSFTDPVAIQTGNLTL
                     SNFTLENYRLFFSNSAAFSPFLVSFIYSIIAATTATILAVVFARVVRKHKSRFDFLFE
                     YGALLPWLLPSTLLAVSLLFTFNQPQFLVLNQILVGSLVILLIAYIVVKIPFSYRMVR
                     AILFSVDDEMEDAARSMGASPFYTMMKVIIPFILPVVLSVIALNFNSLLTDFDLSVFL
                     YHPLAQPLGITIRSAGDETATSNAQALVFVYTIVLMIISGTVLYFTQRPGRKVRK"
     gene            complement(2456..3466)
                     /locus_tag="AC0DU4_000581"
     CDS             complement(2456..3466)
                     /locus_tag="AC0DU4_000581"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236583.1"
                     /translation="MIKFDNIQIKYGDFVAIDNLNLDIHEGEFFTFLGPSGCGKSTTL
                     RALVGFLDPSSGSIEVNGTDVTHLEPEKRGIGIVFQSYALFPTMTVFDNIAFGLKVKK
                     VAPDVIKAKVSAVAAKIKISDQQLQRNVSELSGGQQQRVALARALVLEPKILCLDEPL
                     SNLDAKLRVDLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGYIEQVGTPV
                     EIYHNSQTEFVCDFIGDINVLTDETVHEVLLKNTSVFLEDKKGYIRLEKVRFNRETEQ
                     DFILKGTIIDVEFSGVTIHYTIKVSESQILNVTSIDSQAAIRSVGESVELFITPSDVL
                     QF"
     gene            complement(3569..4636)
                     /locus_tag="AC0DU4_000582"
     CDS             complement(3569..4636)
                     /locus_tag="AC0DU4_000582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HIN4236584.1"
                     /translation="MKKMKVWSTVLATGVALTTLAACSGGSNSTTASSSEEKADKSQE
                     LVIYSNSVSNGRGDWLTAKAKEAGFNIKMVDIAGAQLADRVIAEKNNAVADMVFGIGA
                     VDSNKIRDQKLLVQYKPKWLDKIDQSLSDKDNYYNPVIVQPLVLIGAPDVKEMPKDWT
                     ELASKYKGKYSIYGLQGGTGRAILASILVRYLDEKGDLGVSEKGWEVAKEYFANAYTL
                     QKGESSVVKALDKESPIQYGMIWGSGALVGQKEQNVVFKVMSPEIGVPFVTEQTMILS
                     TSKKQALAKEFIDWFGQSEIQVEYSKNFGSIPANKDALKELPEDTKKFVDQVKPQNID
                     WEAVGKHLDEWVEKAELEYVQ"
     gene            complement(4661..5320)
                     /locus_tag="AC0DU4_000583"
     CDS             complement(4661..5320)
                     /locus_tag="AC0DU4_000583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000793810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1868 domain-containing protein"
                     /protein_id="HIN4236585.1"
                     /translation="MKNLTKIKFKENGEFNHFPGNTVVANLYTKQDLMEVVDIIQSRY
                     RELPFIDKFTLTPRNSIHMTVIELLCHENRETEFWSSNLPLDTPLQEIHDYFAKQLEI
                     FPLLDEEIHMRITEMGKQNILVEPADEASAKRLEEIRTYVSEKAGVCFPNHDRYQFHI
                     SIGYLRIPLTEEEEEEFTKVRAELTEILLEKIPTITVNRIDYTVFEDMRQFVPYHEKF
                     K"
     gene            complement(5500..6510)
                     /gene="galE"
                     /locus_tag="AC0DU4_000584"
     CDS             complement(5500..6510)
                     /gene="galE"
                     /locus_tag="AC0DU4_000584"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA];
                     GO_process: GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HIN4236586.1"
                     /translation="MAILVTGGAGYIGSHTVVELLNLGKEVIIVDNLSNSSILVLDRI
                     EAITGIRPVFYELDVCDKPALRKVFEQESIDAAIHFAGYKAVGESVQKPVMYYKNNIM
                     STLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILK
                     DVHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFG
                     NDYDTLDGTGVRDYIHVVDLAIGHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFE
                     SVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDMCRDTWNWQSKNPNG
                     YN"
     gene            complement(6523..7998)
                     /gene="galT"
                     /locus_tag="AC0DU4_000585"
     CDS             complement(6523..7998)
                     /gene="galT"
                     /locus_tag="AC0DU4_000585"
                     /EC_number="2.7.7.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000848801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0017103 - UTP:galactose-1-phosphate
                     uridylyltransferase activity [Evidence IEA];
                     GO_process: GO:0019388 - galactose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose--hexose-1-phosphate
                     uridylyltransferase"
                     /protein_id="HIN4236587.1"
                     /translation="MKTIIDNFVDRVIEYGMYNEIDKIYVKNRVLALIGEEGTDRISD
                     ENDLKQIKDYLVEIALKNGKIKDLIEEKECLGAELMNFIVPLPSRLNDIFWSSYDISP
                     QEAVEEFYKLSKDSDYIKTSAIAKNIEFRASTKYGELEITINLSKPEKDPKTIAAEKL
                     VKATNYPKCLLCMENEGYQGRINYPARSNHRIIRLKLGDEVWGFQYSPYLYFNEHAIF
                     LNSQHVPMAITSKTFEQLLEIVDILPGYFAGSNSDLPISGGSILSHNHYQGGKHIFPM
                     EKAKFESEFRFKDFEDVNAGIVKWPMSVIRLQSENKNRLLDLATKILNKWREYSDLEV
                     DIIAMTEDVPHHTVTPIARKVDGRYELDIVLRDNHTTEQYPDGVFHPHQDVQHIKKEN
                     IGLIEVMGLAILPPRLKPELEEVGKYLLGEDNAIADYHLEWADQLKEKYPRINKEEVN
                     SVVQHEAGQVFARVLEDAGVYKNTPSGHEAFMRFVKSVGIN"
     gene            complement(8011..8652)
                     /locus_tag="AC0DU4_000586"
     CDS             complement(8011..8652)
                     /locus_tag="AC0DU4_000586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000945326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042803 - protein homodimerization
                     activity [Evidence IEA];
                     GO_process: GO:0006793 - phosphorus metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA];
                     GO_process: GO:0030643 - intracellular phosphate ion
                     homeostasis [Evidence IEA];
                     GO_process: GO:2000185 - regulation of phosphate
                     transmembrane transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex PhoU family protein"
                     /protein_id="HIN4236588.1"
                     /translation="MLRLYLENEIIELSNNLETIWVSVLDKYEKLFEYLSNEERIELI
                     KEDLIINESVLNVDKKGYELICLQHPVSYDLRRIISVIKISTDIERIGDRIVEILKNL
                     QIIQNNEILKKIISEIKILHEVIGLHMNRAISCYREEQSGCLDMVVIQKQNEIEELST
                     NIEKKIMNYIFEDDGNVSEVIGALDIIHHLDKIAHTTQSIYKWIMYRKYGNIN"
     gene            complement(8710..9093)
                     /locus_tag="AC0DU4_000587"
     CDS             complement(8710..9093)
                     /locus_tag="AC0DU4_000587"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236589.1"
                     /translation="MLVNEMEITDHRVDNLFEKGKNEIKDPIGTNSVLNKKIILQKIR
                     KLSNQPSGYWIGSLDERFLDHAIINQIDVTSEQIVLMSDGFYEFYQNNQNKTFEELIK
                     MRFNSSAIDPIYGKKDDASIVVIDV"
     gene            complement(9265..9561)
                     /locus_tag="AC0DU4_000588"
     CDS             complement(9265..9561)
                     /locus_tag="AC0DU4_000588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236590.1"
                     /translation="MVKINKICSIQGSSVENEDIVGSQNQYFWIIGGATDLYNSKEEI
                     GYSVSEVVHILSESLSVNCKESKTLKQIFETALLEVKDEIGLNSYELTEYNKMK"
     gene            complement(9545..11704)
                     /gene="pfbA"
                     /locus_tag="AC0DU4_000589"
     CDS             complement(9545..11704)
                     /gene="pfbA"
                     /locus_tag="AC0DU4_000589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multi-ligand-binding adhesin PfbA"
                     /protein_id="HIN4236591.1"
                     /translation="MLKIVKKLEVLMKYFVPNEVFSIRKLKVGTCSVLLAISILGSQG
                     ILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTTNGLDNSLSVNS
                     ISSNGTIRSNSQLDNRTVESTVTSTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAV
                     GDGIHDDRQAIQDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILN
                     GINIKNHPSIVFMTGLFTDDGAQVEWGPTEDISYSGGTIDMNGALNEEGTKAKNLPLI
                     NSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMKDGQ
                     IISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTL
                     STQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVN
                     AYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSAEYLGKVSDITVTKNVIN
                     NNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYI
                     SFIKSNANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVI
                     DSNQKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENHINKSKEIVDVK
                     QKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK"
     gene            complement(12835..14061)
                     /locus_tag="AC0DU4_000590"
     CDS             complement(12835..14061)
                     /locus_tag="AC0DU4_000590"
                     /EC_number="2.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001134527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="HIN4236592.1"
                     /translation="MPNYNIPFSPPDITEAEITEVVDTLRSGWITTGPKTKELERRLS
                     LYTQTPKTVCLNSATAALELILRVLEVGPGDEVIVPAMTYTASCSVITHVGATPVMVD
                     IQADTFEMDYDLLEQAITEKTKVIIPVELAGIVCDYDRLFQVVEKKRDFFTASSKWQK
                     AFNRIVIVSDSAHALGSIYKGQPSGSIADFTSFSFHAVKNFTTAEGGSATWKANPVID
                     DEEMYKEFQILSLHGQTKDALAKMQLGSWEYDIVTPAYKCNMTDIMASLGLVQLDRYP
                     SLLQRRKDIVDRYDSGFAASRIHPLAHKTETVESSRHLYITRVEGASLEERNLIIQEL
                     AKAGIASNVHYKPLPLLTAYKNLGFDMTNYPKAYAFFENEITLPLHTKLSDEEVDYII
                     ETFKTVSEKVLTLSKK"
     gene            complement(14104..14796)
                     /locus_tag="AC0DU4_000591"
     CDS             complement(14104..14796)
                     /locus_tag="AC0DU4_000591"
                     /EC_number="2.7.8.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000922225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HIN4236593.1"
                     /translation="MLKWEDLPVEMKSSEVESYYQLVSKRKGSLIFKRCLDWVLALVL
                     LVLTSPIFLILSIWIKLDSKGPVIYKQERVTQYNRRFKIWKFRTMVTDADKKGSLVTS
                     ANDSRITKVGNFIRRVRLDELPQLVNVLKGEMSFVGTRPEVPRYTEQYSPEMMATLLL
                     QAGITSPASINYKDEDTIISQMTEKGLSVDQAYVEHVLPEKMRYNLAYLREFSFFGDI
                     KIMFQTVFEVLK"
     gene            complement(14969..16720)
                     /locus_tag="AC0DU4_000592"
     CDS             complement(14969..16720)
                     /locus_tag="AC0DU4_000592"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236594.1"
                     /translation="MQNKQEQWAVLKRLMSYLKPYGLLTFLALSFLLATMVIKSVIPL
                     VASHFIDQYLSNLNQLAVTVLLVYYGLYILQTVVQYVGNLLFARVSYSIVRDIRRDAF
                     ANMEKLGMSYFDKTPAGSIVSRLTNDTETISDMFSGILSSFISAVFIFLTTLYTMLVL
                     DFRLTALVLLFLPLIFLLVNLYRKKSVKIIEKTRSLLSDINSKLAENIEGIRIIQAFN
                     QEKRLQAEFDEINQEHLVYANRSVALDALFLRPAMSLLKLLGYAVLMAYFGYRGFSIG
                     ITVGTMYAFIQYINRLFDPLIEVTQNFSTLQTAMVSAGRVFALIDERTYEPLQENGQA
                     KVQEGNIRFEHVCFSYDGKHPILDDISFSVNKGETIAFVGHTGSGKSSIINVLMRFYE
                     FQSGRVLLDDVDIRDFSQEELRKNIGLVLQEPFLYHGTIKSNIAMYQETSDEQVQAAA
                     AFVDADSFIQELPQGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANID
                     SETESLVQASLAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIESGTHEELLALGV
                     TYHKMYSLQAGAMADTL"
     gene            complement(16710..18455)
                     /locus_tag="AC0DU4_000593"
     CDS             complement(16710..18455)
                     /locus_tag="AC0DU4_000593"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236595.1"
                     /translation="MSIIQKLWWFFKLEKRRYLVGIVALVLVSVLNLIPPMVMGRVID
                     AITSGQLTQQDLLLSLFYLLLAAFGMYYLRYVWRMYILGTSYCLGQIMRSRLFKHFTK
                     MSSAFYQTYRTGDLMAHATNDINALTRLAGGGVMSAVDASITALVTLLTMLFSISWQM
                     TLVAILPLPFMAYTTSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQAD
                     ELKSFQAVNELTFQKNLQTMKYDSLFDPMVLLFVGSSYVLTLLVGSLMVQEGQITVGN
                     LVTFISYLDMLVWPLLAIGFLFNTTQRGKVSYQRIENLLSQESPVQDPEFPLDGIENG
                     RLEYAIDSFAFENEETLTDIHFSLAKGQTLGLVGQTGSGKTSLIKLLLREYDVDKGTI
                     YLNGHDIRDYRLTDLRSLMGYVPQDQFLFATSILDNIRFGNPNLPLSAVEEATKLARV
                     YQDIVDMPQGFDTLIGEKGVSLSGGQKQRLAMSRAMILDPDILILDDSLSAVDAKTEY
                     AIIDNLKETRKDKTTIITAHRLSAVVHADFILVLQNGQIIERGTHEDLLAMDGWYAQT
                     YQSQQLEMKGEEDAE"
     gene            complement(18661..18957)
                     /locus_tag="AC0DU4_000594"
     CDS             complement(18661..18957)
                     /locus_tag="AC0DU4_000594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001276342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DUF421 domain-containing protein"
                     /protein_id="HIN4236596.1"
                     /translation="MSASDVALKLRSQGIFQMKQVKRAVQEQNGQLIVVQMGDENPKY
                     PVVTDGVIQVDVLESIGRSEEWLLDNLSKQGHDNVANIFIAEYDKGAVTVVTYE"
     gene            complement(19110..19567)
                     /locus_tag="AC0DU4_000595"
                     /pseudo
     CDS             complement(19110..19567)
                     /locus_tag="AC0DU4_000595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730499.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3290 family protein"
     gene            19701..20528
                     /locus_tag="AC0DU4_000596"
     CDS             19701..20528
                     /locus_tag="AC0DU4_000596"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006596696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004518 - nuclease activity [Evidence
                     IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HIN4236597.1"
                     /translation="MKLISWNIDSLNAALTSDSARAKLSQEVLQTLVAENADIIAIQE
                     TKLSAKGPTKKHVEILEELFPGYENTWRSSQEPARKGYAGTMFLYKKELTPTVTFPEI
                     GAPSTMDLEGRIITLEFDAFFVTQVYTPNAGDGLKRLEERQVWDVKYAEYLAELDKEK
                     PVLATGDYNVAHNEIDLANPASNRRSPGFTDEERAGFTNLLATGFTDTFRHVHGDVPE
                     RYTWWAQRSKTSKINNTGWRIDYWLTSNRIADKVTKSDMIDSGARQDHTPIVLEIDL"
     gene            20540..20677
                     /locus_tag="AC0DU4_000597"
     CDS             20540..20677
                     /locus_tag="AC0DU4_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HIN4236598.1"
                     /translation="MDYNAVIPELLVSNIEQSRSFYCGLLGFRIEYQRPEENFLLKSV
                     N"
     gene            20788..20916
                     /locus_tag="AC0DU4_000598"
     CDS             20788..20916
                     /locus_tag="AC0DU4_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000646799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-1-phosphate uridylyltransferase"
                     /protein_id="HIN4236599.1"
                     /translation="MKANYPIYRPLTKRKFRVSDPYIYPHKFAVLDPDGYFLRFSE"
     regulatory      21299..21394
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            21794..22375
                     /locus_tag="AC0DU4_000599"
     CDS             21794..22375
                     /locus_tag="AC0DU4_000599"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016763 - pentosyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0043101 - purine-containing compound
                     salvage [Evidence IEA];
                     GO_process: GO:0046110 - xanthine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HIN4236600.1"
                     /translation="MKLLEDRILKDGHILGDNILKVDSFLTHQVDFSLMREIGKVFAE
                     KFAAAGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQ
                     VTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQD
                     GRDLLEKAGYPVLSLARLDRFENGQVVFKEADL"
     gene            22375..23637
                     /locus_tag="AC0DU4_000600"
     CDS             22375..23637
                     /locus_tag="AC0DU4_000600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001194492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0015851 - nucleobase transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleobase:cation symporter-2 family protein"
                     /protein_id="HIN4236601.1"
                     /translation="MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLT
                     YLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVAFQSVAPLIMIGQSHGSGAMFGAL
                     IASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLL
                     LAAITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPTP
                     LYFGMPTFEISSIVMMCIIATVSMVESTGVYLALSDITKDPLDSTRLRNGYRAEGLAV
                     LLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGLLPKFGALAQIIPSS
                     VLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTA
                     FQMFFSNGIVVASLLAIVLNAVLNHKKK"
     gene            complement(23688..24149)
                     /locus_tag="AC0DU4_000601"
     CDS             complement(23688..24149)
                     /locus_tag="AC0DU4_000601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DpnD/PcfM family protein"
                     /protein_id="HIN4236602.1"
                     /translation="MKTKQLVASEEVYDFLKVIWPDYETESRYDNLSLIVCTLSDPDC
                     VRWLSENMKFGDEKQLALMKEKYGWEVGDKLPEWLHSSYHRLLLIGELLESNLKLKKY
                     TVEITETLSRLVSIEAENPDEAERLVREKYKSCEIVLDADDFQDYDTSIYE"
     gene            complement(24146..24910)
                     /locus_tag="AC0DU4_000602"
     CDS             complement(24146..24910)
                     /locus_tag="AC0DU4_000602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type-2 restriction enzyme DpnI"
                     /protein_id="HIN4236603.1"
                     /translation="MELHFNLELVETYKSNSQKARILTEDWVYRQSYCPNCGNNPLNH
                     FENNRPVADFYCNHCSEEFELKSKKGNFSSTINDGAYATMMKRVQADNNPNFFFLTYT
                     KNFEVNNFLVLPKQFVTPKSIIQRKPLAPTARRAGWIGCNIDLSQVPSKGRIFLVQDG
                     QVRDPEKVTKEFKQGLFLRKSSLSSRGWTIEILNCIDKIEGSEFTLEDMYRFESDLKN
                     IFVKNNHIKEKIRQQLQILRDKEIIEFKGRGKYRKL"
     gene            complement(25091..25495)
                     /locus_tag="AC0DU4_000603"
     CDS             complement(25091..25495)
                     /locus_tag="AC0DU4_000603"
                     /EC_number="3.1.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA];
                     GO_function: GO:0016836 - hydro-lyase activity [Evidence
                     IEA];
                     GO_function: GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HIN4236604.1"
                     /translation="MKDFHFDAISAFENYEIEKMRDGHVVVTTKVVNSSLNYYGNAHG
                     GYLFTLCDQISGLVVISLGLDGVTLQSSINYLKAGKLDDVLTIKGECVHQGRTTCVMD
                     VDITNQEGRNVCKATFTMFVTGQRSEERRVSI"
     gene            complement(25565..27046)
                     /locus_tag="AC0DU4_000604"
     CDS             complement(25565..27046)
                     /locus_tag="AC0DU4_000604"
                     /EC_number="2.7.7.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose--hexose-1-phosphate
                     uridylyltransferase"
                     /protein_id="HIN4236605.1"
                     /translation="MILVDKFVTHVISESSFEEMDRIYLTNRVLARVGEGVLEVETNL
                     DKLIDLKDQLVEEAVRLEMIEDSQTAREILGTELMDLVTPYPSQVNRDFWEAYVHSPE
                     QAIEDFYQLSQKNDYIKLKAIAKNIAYRVPSDYGELEITINLSKPEKDPKEIAVAKLV
                     QASNYPQCQLCLENEGYHGRVNHPARSNHRIIRFEMVGQEWGFQYSPYAYFNEHCIFL
                     DGQHRPMAISRQSFERLLAIVEQFPGYFAGSNADLPIVGGSILTHDHYQGGRHVFPME
                     LAPLQKTFRFAGFEQVKAGIIKWPMSVLRLTSDSKEDLINLADKIFQEWRQYSDSSVQ
                     ILAETDGTPHHTITPIARKRDGQFELDLVLRDNQTSAEHPDGIYHPHKDVQHIKKENI
                     GLIEVMGLAILPPRLKEEVEQVASYLVGEAVTVADYHQEWADQLKSQHPDLTDKEKAL
                     AIVKDSVGAIFARVLEDAGVYKQTEQGQTAFMRFVEHVGILLD"
     gene            complement(27065..28243)
                     /locus_tag="AC0DU4_000605"
     CDS             complement(27065..28243)
                     /locus_tag="AC0DU4_000605"
                     /EC_number="2.7.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004335 - galactokinase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006012 - galactose metabolic process
                     [Evidence IEA];
                     GO_process: GO:0046835 - carbohydrate phosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="galactokinase"
                     /protein_id="HIN4236606.1"
                     /translation="MAQHLTTEVLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGG
                     HVFPAAISLGTYGAARKRDDQVLRFYSANFEDKGIIEVPLADLKFEKEHNWTNYPKGV
                     LHFLQEAGHVIDKGFDFYVYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLDRLDLVK
                     IGKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTN
                     KRRELADSKYNERRAECEKAVEELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRAR
                     HAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLEHDYEVTGLELDTLVHTAWAQEG
                     VLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD
                     "
     gene            28408..29415
                     /gene="galR"
                     /locus_tag="AC0DU4_000606"
     CDS             28408..29415
                     /gene="galR"
                     /locus_tag="AC0DU4_000606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding transcriptional regulator GalR"
                     /protein_id="HIN4236607.1"
                     /translation="MATLKDIAQLASVSIATVSRVLNRDQSLSVTEETRHRILTVAEE
                     LGYTKHLKTGESHKPKQKIAIIQWVSEQGELDDLYYYQIRLGIEKRAQELDYDILRYF
                     NDHPFTLSEEVIGILCIGKFSRAQISAFEEYQKPLVFLDSDTLSLGHTCIITDFYTAM
                     KQVVDYFLSQGMDRIGILTGLEETTDQEEIIQDKRLENFKNYSQARGIYHDELVFQGR
                     FTAQSGYDLMKEAIQSLGDQLPPAFFAASDSLAIGALRALQEAGISLPDRVSLISFND
                     TSLTKQVYPPLSSITVYTEEMGRAGMDILNKEVLHGRKIPSLTMLGTRLTLRESTLNQ
                     E"
     gene            complement(29461..30498)
                     /locus_tag="AC0DU4_000607"
     CDS             complement(29461..30498)
                     /locus_tag="AC0DU4_000607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding dehydrogenase"
                     /protein_id="HIN4236608.1"
                     /translation="MKSAVYTKAGQVGLASIERPQIIEADDVIIRVVRACVCGSDLWR
                     YRNPETKAGHKNSGHEAIGIVEEAGEAITTVKPGDFVIVPFTHGCGECDACLAGFDGS
                     CDNHIGNNLGGDFQAEYIRFHYANWALVKIPGQPSDYTEGMLKSLLTLADVMPTGYHA
                     ARVANVQKGDKVVVIGDGAVGQCAVIAAKMRGASQIILMSRHEDRQKMAMESGATAVV
                     AERGQEGITKVREILGGGADAALECVGTEAAIEQALGVLHNGGRMGFVGVPHYNNRAL
                     GSTFMQNISVAGGAASATTYDKQFLLKAVLDGDINPGRVFTSSYKLEDIDQAYKDMDE
                     RKTIKSMIVIE"
     gene            complement(30499..30852)
                     /gene="nmlR"
                     /locus_tag="AC0DU4_000608"
     CDS             complement(30499..30852)
                     /gene="nmlR"
                     /locus_tag="AC0DU4_000608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="stress response transcriptional regulator NmlR"
                     /protein_id="HIN4236609.1"
                     /translation="MNIKSASDLLGISADTIRYYERVGLVPPITRTATGIRDFQDQDI
                     EALEFIKCFRSAGVSVDSLVDYMSLYQKGDETREERLGILEEEKQKLEERLSQLQTAL
                     NRLNLKIKLYKEGKF"
     gene            complement(31096..31986)
                     /gene="czcD"
                     /locus_tag="AC0DU4_000609"
     CDS             complement(31096..31986)
                     /gene="czcD"
                     /locus_tag="AC0DU4_000609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation diffusion facilitator family transporter
                     CzcD"
                     /protein_id="HIN4236610.1"
                     /translation="MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDA
                     IAIGISAFLETISNREEDNQYTLGYKRFSLLGALVTAVILVTGSVLVILENVTKILHP
                     QPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
                     RFTDWYILDPLLSLVISFFILSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNV
                     ASLNQLNLWTMDALEKNAIVHVCLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLE
                     THQTHKRKVCDLERSYEHQH"
     gene            32119..32655
                     /gene="sczA"
                     /locus_tag="AC0DU4_000610"
     CDS             32119..32655
                     /gene="sczA"
                     /locus_tag="AC0DU4_000610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator SczA"
                     /protein_id="HIN4236611.1"
                     /translation="MTNIDRRISKTKKAIYQAFIQLLNAKGYEATTVQDIIDLADVGR
                     STFYCHYESKELLLDQLCRYLFHHLFEREQAISTEDYLAHLFLHFHKNQDHITSLLFS
                     KNDYFLRQLHKELEHHVYSVLADNLKEAHPNLPTSYLQHLVMSNFIETLTWWLKKGQD
                     FTDQEVVQFYLDLLIPKN"
     gene            complement(32821..33627)
                     /gene="pnuC"
                     /locus_tag="AC0DU4_000611"
     CDS             complement(32821..33627)
                     /gene="pnuC"
                     /locus_tag="AC0DU4_000611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015663 - nicotinamide mononucleotide
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0015890 - nicotinamide mononucleotide
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide riboside transporter PnuC"
                     /protein_id="HIN4236612.1"
                     /translation="MHTYLQKKIENIKTTLGEMSGGYRRMVAAMADLGFSGTMKAIWD
                     DLFAHRSFAQWIYLLVLGSFPLWLELVYEHRIVDWIGMICSLTGIICVIFVSEGRASN
                     YLFGLINSVIYLILALQKGFYGEVLTTLYFTVMQPIGLLVWIYQAQFKKEKQEFVARK
                     LDGKGWTKYLSISVLWWLAFGFIYQSIGANRPYRDSITDATNGVGQILMTAVYREQWI
                     FWAATNVFSIYLWWGESLQIQGKYLIYLINSLVGWYQWSKAAKQNTDLLN"
     gene            complement(33972..35492)
                     /locus_tag="AC0DU4_000612"
     CDS             complement(33972..35492)
                     /locus_tag="AC0DU4_000612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease/substrate-binding
                     protein"
                     /protein_id="HIN4236613.1"
                     /translation="MTNLIATFQDRFGDWLTALSQHLQLSLLTLLLAILLAIPLAVYL
                     RYHEKLADWVLQIAGIFQTIPSLALLGLFIPLMGIGTLPALTALVIYAIFPILQNTIT
                     GLNGIDPSLQEAGIAFGMTRWERLKKFEIPLAMPVIMSGIRTAAVLIIGTATLATLIG
                     AGGLGSFILLGIDRNNASLILIGALSSAVLAIAFNFLLKVMEKAKLRTIFSGFALVAL
                     LLGLSYSPALLAQKEKENLIIAGKIGPEPEILANMYKLLIEENTSMTATVKPNFGTTS
                     FLYEALKKGDIDIYPEFTGTVTESLLQPSPKVSHEPEQVYQVARDGIAKQDHLAYLKP
                     MSYQNTYAVAVPKKIAQEYGLKTISDLKKVEGQLKAGFTLEFNDREDGNKGLQSMYGL
                     NLNVATMQPALRYQAIQSGDIQITDAYSTDAELERYDLQVLEDDKQLFPPYQGAPLMK
                     EALLKKHPELERVLNTLAGKITENQMSQLNYQVGVEGKSAEQVAKEFLQEQGLLKK"
     gene            complement(35485..36213)
                     /locus_tag="AC0DU4_000613"
     CDS             complement(35485..36213)
                     /locus_tag="AC0DU4_000613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4236614.1"
                     /translation="MIEYKNVALRYTEKDVLRDVNLQIEDGEFMVLVGPSGSGKTTML
                     KMINRLLEPTDGNIYMDGKRIKDYDERELRLSTGYVLQAIALFPNLTVEENIALIPEM
                     KGWTKEEIAQKTEELLAKVGLPVAEYGHRLPSELSGGEQQRVGIVRAMIGQPKILLMD
                     EPFSALDAISRKQLQVLTKELHKEFGMTTIFVTHDTDEALKLADRIAVLQDGEIRQVS
                     NPETILKAPATDFVADLFGGSIHD"
     gene            complement(36228..36992)
                     /locus_tag="AC0DU4_000614"
     CDS             complement(36228..36992)
                     /locus_tag="AC0DU4_000614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HIN4236615.1"
                     /translation="MSQQVKNAHNLYIHAIQDGRVAEAQAQSVGDTYIQHSTGVPDGK
                     EGFAAFFADFFERHPERQIKIVRTIEDGNLVFVHVHQYLNGGEAQWVTTDTFRADENG
                     RIVEHWDVIDYYRTPENDQLDQIFGDFEIKDLDKKAENKKLVRRFLTEIFQNGELEQW
                     SDYVADDLIQHNHEIGQGSAAYKNYVAEYSVTFDFVFQLLGQGNYVVSYGQTQIDGVA
                     YAQYDIFRLENGKIVEHWDNKEVMPKVEDLTNRGKF"
     gene            complement(36996..37439)
                     /locus_tag="AC0DU4_000615"
     CDS             complement(36996..37439)
                     /locus_tag="AC0DU4_000615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="HIN4236616.1"
                     /translation="MKDGHLLAHHIRLLNGRIFQKLLSQDPEALYRGEQGKILAVLWN
                     SETGCATATDIALATGLANNTLTTMIKKLEEQKLVIVSPCGKDKRKKYLVLTELGKSQ
                     KEVGHRVSQKLDTIFYKGFSEEEIHQFEGFQERILANLKEKGNEV"
     gene            complement(38121..38417)
                     /locus_tag="AC0DU4_000616"
     CDS             complement(38121..38417)
                     /locus_tag="AC0DU4_000616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HIN4236617.1"
                     /translation="MAEPNLESLIKDLYNHARHDLSEDLVAALLETAKKLPTTNEQLQ
                     AVRLSGLVNRELLLNPKHPAPELLNLARFIKREEAKYRGTATSALMYEELFKML"
     gene            complement(38439..39503)
                     /gene="pepA"
                     /locus_tag="AC0DU4_000617"
     CDS             complement(38439..39503)
                     /gene="pepA"
                     /locus_tag="AC0DU4_000617"
                     /EC_number="3.4.11.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamyl aminopeptidase"
                     /protein_id="HIN4236618.1"
                     /translation="MTTLFSKIKEVTELAAVSGHEAPVRAYLREKLTPYVDEVVTDGL
                     GGIFGIKHSEAVDAPRVLVASHMDEVGFMVSEIKPDGTFRVVEIGGWNPMVVSSQRFK
                     LLTRDGHEIPVISGSVPPHLTRGKGGPTMPAIADIVFDGGFADKAEAESFGIRPGDTI
                     VPDSSAILTANEKNIISKAWDNRYGVLMVSELAEALSGQKLGNELYLGSNVQEEVGLR
                     GAHTSTTKFDPEVFLAVDCSPAGDVYGGQGKIGDGTLIRFYDPGHLLLPGMKDFLLTT
                     AEEAGIKYQYYCGKGGTDAGAAHLKNGGVPSTTIGVCARYIHSHQTLYAMDDFLEAQA
                     FLQALVKKLDRSTVDLIKHY"
     gene            39904..40605
                     /locus_tag="AC0DU4_000618"
     CDS             39904..40605
                     /locus_tag="AC0DU4_000618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="HIN4236619.1"
                     /translation="MTKTILVTGGTSYISSHTVKALLNAGYQVHVLDNLSTGNRAAVD
                     SRASFKELDVYDASALKAYLEENQIDAVLHCAGEIVVSESIENPSKYFTANVAGMNQV
                     LKVLSEVGIQKIMFSSTASLYGNNCIDKPVTEDTLLDPVNPYAETKLMGERMIYWMAN
                     RYDWKYVIFRYFNAAGAEMDASNGLRVKNPTHIIPNINKTALGQNDSLKIFGDDYDTR
                     DGSCIRDYIYVLDLA"
     gene            40621..40731
                     /locus_tag="AC0DU4_000619"
     CDS             40621..40731
                     /locus_tag="AC0DU4_000619"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001108391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase"
                     /protein_id="HIN4236620.1"
                     /translation="MNYLFQEDSSSQIFNLGTKKGYTIKEIFKTAEELLN"
     gene            41028..41987
                     /locus_tag="AC0DU4_000620"
     CDS             41028..41987
                     /locus_tag="AC0DU4_000620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236621.1"
                     /translation="MKLSHYLIGLLLLLVFLSISIGTSDFSWGKLFDFDQQTWLLFQE
                     SRLPRTISILLTASSMSMAGLLMQTITQNQFAAPSTVGTTEAAKLGMVLSLFVFPSAS
                     LTQKMLFAFVSSIVFTLFFLAFMTIFTVKERWMLPLIGIIYSGIIGSVTEVIAYRFNL
                     VQSMTAWTQGSFSMIQTHQYEWLFLGLIILITVWKLSQTFTIMNLGKETSESLGISYS
                     LLEKLALFLVALTTSVTMITVGGLPFLGVIVPNLVRKRYGDNLSQTKLMVALVGANLV
                     LACDILSRVLIRPYELSVSLLLGIIGSLVFILLLWRGGRKDAD"
     gene            41977..42933
                     /locus_tag="AC0DU4_000621"
     CDS             41977..42933
                     /locus_tag="AC0DU4_000621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HIN4236622.1"
                     /translation="MQTKSKHTKLFWILIILAIGACLLYFWPITHLSAFAWKLRSQKI
                     IVYLLVAIATGISTISFQTLTENRFLTPSILGIESFYVLLQTLLLVFESKFLQLGKSP
                     ILEFLVLLLVQSFFFLALQGYLKTLMKQDLVFILLICLALRSLFRNISTFLQVLMDPN
                     EYDKLQNSLFASFQHLNTSILAIGSLIILALTIFFFRKAVVLDVLHLQRETAQILGLD
                     VEKEQKELLWGIVLLTSTATALVGPMAFFGFMLANLTYLIVKDYQHKLLFIVAILVGF
                     ISLTLGQALIERVFALEIRISMIIESVGGFLFFILLYRRSRQ"
     gene            42930..43682
                     /locus_tag="AC0DU4_000622"
     CDS             42930..43682
                     /locus_tag="AC0DU4_000622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000764290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4236623.1"
                     /translation="MKLENIDKSIQKQDILQGISLEVSPQKLTAFIGPNGAGKSTLLS
                     IMSRLTKKDQGVLSIKGREIESWNSQELAQELTILKQKINYQAKLTVEELVSFGRFPY
                     SRGRLRSEDWEKIRETLNYLELTNLKDRYINSLSGGQLQRVFIAMVLAQDTDFILLDE
                     PLNNLDIKQSVSMMQILRRLVEELGKTIIIVLHDINMASQYADEIVAFKDGQVFSKGR
                     TDQIMQADLLSQLYEIPITLADINNKKICIYS"
     gene            43778..>44731
                     /locus_tag="AC0DU4_000623"
     CDS             43778..>44731
                     /locus_tag="AC0DU4_000623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="siderophore ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4236624.1"
                     /translation="MKTSLKLYFTALVASFLLLLGACSTNSSTSQTETSSSAPTEVTI
                     KSSLDEVKLSKVPEKIVTFDLGAADTIRALGFEKNIVGMPTKTVPTYLKDLVGTVKNV
                     GSMKEPDLEAIAALEPDLIIASPRTQKFVDKFKEIAPTVLFQASKDDYWTSTKANIES
                     LASAFGETGTQKAKEELAKLDKSIQEVATKNESSDKKALAILLNEGKMAAFGAKSRFS
                     FLYQTLKFKPTDTKFEDSRHGQEVSFESVKEINPDILFVINRTLAIGGDNSSNDGVLE
                     NALIAETPAAKNGKIIQLTPDLWYLSGGGLESTKLMIEDIQK"
BASE COUNT        13468 a         9832 c         7730 g        13701 t
ORIGIN      
        1 caaaaggaca aaaacatctg tccctttgtt tactaaattt cagctaattt cttcgacata
       61 aataacacct acaatattag caatttcttc catcagtcga agatgttcaa atctacctga
      121 taattccaga gtaataaatg acgctatttt tttgtccgga acatcaaagt attcaattct
      181 gtcagaatta acatctccaa acgctgttct tgaatcggtc attctgatac cattttctgc
      241 acaataaacc aatacacgat tataggcttc tgtagattta actactatat acaattcaat
      301 cattttagaa cgattttgca gatatttttt tagtggttgg aacatggata tcacacccca
      361 aacagaaatg gctactaaaa gagctccctc ataaaaacct actccaatag ctaatccaat
      421 tcctgccgaa gcccaaatgc ctgctgcagt tgtcaaacct gtaattttct ttttatctgt
      481 aataagaatc gttccagcgc ctagaaaacc cacacctgat ataacttgag ctcctaatcg
      541 tgtaggatct cctgtcccaa atttataaga tacgtattca ttcgtcatca taatcaaaca
      601 tgcagctaga caaacaatac tataagttcg gatgcctgca ggctgggatt tgctccctct
      661 ctctaaacca attatactac caatgactac tgataaaaca atcctgacaa ctatttcaat
      721 atttgataac ccaagactag tggctgtcat gattatttcc ttactttacg ccccggtctt
      781 tgtgtgaagt ataataccgt tccagaaata atcatcagaa caattgtata aacaaatacc
      841 agagcttgtg cattagatgt tgctgtttca tcacctgcag atcgaatcgt aatacctaat
      901 ggttgagcta ggggatggta aaggaataca gataagtcga agtcagttaa taaagagtta
      961 aagtttaaag caataacaga gagaacaacc ggtaaaataa atggaatgat aaccttcatc
     1021 atagtataaa aaggtgaagc acccatactt cttgctgcat cttccatctc atcatcaaca
     1081 ctaaataaaa tagcacgtac cattctataa gaaaatggga tttttacaac tatatatgca
     1141 ataagtagaa ttaccaaact acctaccaaa atctgattca agacaagaaa ttgtggctga
     1201 ttaaaagtaa ataataaact tactgctaaa agtgtacttg gtagtaacca aggaagtaga
     1261 gcaccatatt caaataagaa atcaaaacga gatttatgtt ttctgacaac acgagcaaat
     1321 acaactgcga gaattgttgc tgttgtcgca gcaataatag aataaataaa gctgaccaag
     1381 aatggagaga atgccgcact attactaaag aataagcgat aattttctaa agtaaagttt
     1441 gataatgtta agttacctgt ttgaattgca actggatctg taaatgagta taatactata
     1501 aaaattagtg gaagcatgaa aactgtgaac aatccatatg ctacaatgtg agcaatgata
     1561 ttccaaggct tagacgcaat tttttgtttt ttaagaggcg ctttagtctt agagatagaa
     1621 atataatttc cacctttttc tatcttattc atgatagtaa gcaaaattgt agttgcaata
     1681 cctaaaataa ttgcaagtaa ggcagctaaa tcacgagaat tccccatccc tgcaaatgta
     1741 ataatcattg gatttatagt ttgaaattct ttaccaccaa caatcatggg tgctgctact
     1801 gcagataaac cactaagaaa aaccataata gtaagtgcaa atagagttgg aattaaggtt
     1861 ggtaacacta cttttcggaa aacagtaaat ggttttgctc ccatatttcg agcagcctca
     1921 atagtgtgat agtcaacgct tcgaattgta tttgttaaaa acaatgtatg attagcagtt
     1981 cctgaaaatg tcataatgaa taagactgca ccatacccaa taaaccagtt agggtctaaa
     2041 gaagggataa cattttgtaa aaattttgta atcaatccat aaggaccata gacaaattta
     2101 tatccagtcg ctaaaaccac tcctccataa attaaagagg tcatataacc taattttaaa
     2161 attttagcac ctttaatatc aaagtactct gtaaatagaa cacaaagaat acctacgaca
     2221 ttaactgtaa taataagtga aaatgctaac ttaaaactgt tcataatact ctgaagtgcc
     2281 ctctgagatt ttagaacacg atgtacagca tcaagggaaa attctcctcc ttttacaaat
     2341 acattcacta ctagatcaaa gtttggataa ataataaatg ttactaagaa ccagattaac
     2401 cctaaacgaa taagccaatc ttttaaattt aatttatgac gcatactgca cctccttaaa
     2461 attgcagaac gtctgatggt gtgataaata attccacact ttctccgaca gatctaatag
     2521 cagcctgact atcaatactt gttacattaa gaatctgact ttcagaaact tttattgtat
     2581 agtgaattgt aactccagaa aactcaacat caataattgt cccttttaga ataaaatctt
     2641 gttcagtttc acgattgaat cgaactttct ctaatcgaat gtatcctttt ttatcctcta
     2701 agaaaacgct tgtatttttc aataatactt cgtggactgt ttcatcggtc aaaacattaa
     2761 tatctccaat aaaatcacat acaaattcag tttgagaatt atgataaatc tctactggtg
     2821 taccgacctg ttcgatgtat ccattgttaa agactgcaat tctatcagat aaagtcaagg
     2881 cttcctcttg atcatgagta acatataaag tagtaatacc taactctttt tgaagtcttt
     2941 tcaactcttt tctcaaatct acacgtaatt ttgcgtcaag gtttgacaat ggttcatcta
     3001 gacaaagaat tttaggttca agaaccagag cacgagccaa tgctaccctt tgttgttgac
     3061 ccccagataa ttctgataca ttacgctgta actgttgatc agagatctta atttttgctg
     3121 ccactgctga tactttagct ttaataacat ctggagctac cttcttaact tttaaaccaa
     3181 atgcaatatt atcaaaaaca gtcatagttg gaaatagcgc ataagattga aatacaatac
     3241 caattccacg cttttcaggt tccaaatgag tgacatctgt tccattaact tcaatacttc
     3301 ctgatgatgg atctaaaaaa cctaccaatg ctctcaaagt agttgattta ccacatcctg
     3361 aaggcccaag aaatgtaaag aattcccctt catgtatatc taaattcaga ttatcaattg
     3421 caacaaaatc accatattta atttgaatat tatcaaattt aatcatctca ctaactccct
     3481 ctattactaa accaaaagcc tctctttatt tcttccttaa atttagaaat aatagagaga
     3541 cttggacata aaaaataact cttatttctt attgtacgta ttctaattca gctttttcta
     3601 cccattcatc caaatgcttt ccaacagctt cccagtcaat attttgtggt ttcacttgat
     3661 caacaaattt cttagtatct tctggtagct ctttgagggc atctttattg gcagggatag
     3721 agccaaagtt tttactgtac tctacttgaa tttcagattg accaaaccaa tcaataaatt
     3781 ctttagccaa tgcttgcttc ttacttgtac tcaaaatcat tgtttgctca gttacaaatg
     3841 gaaccccaat ttcaggagac atcactttaa aaacaacatt ttgttctttt tgaccaacta
     3901 gagccccgga cccccagatc ataccgtatt gaattgggct ttctttatct aacgctttaa
     3961 caactgagct ttcacctttt tgaagagtat aggcatttgc aaagtattct tttgcaactt
     4021 cccatccttt ttctgatacg cctaaatctc ctttttcatc aaggtaacga actaagatac
     4081 ttgctagaat tgcccgtcct gtaccacctt gaagaccata aattgaatat ttacctttat
     4141 acttactagc taactctgtc cagtctttag gcatttcttt tacatcaggc gccccaatta
     4201 aaactaatgg ttgaacaatc acaggattat aataattatc tttatctgat aaagattgat
     4261 caattttatc taaccattta ggcttgtact gtacgagtaa tttttgatct ctaattttat
     4321 ttgagtcaac agcaccaatt ccaaatacca tatctgcaac tgcattattc ttctcagcaa
     4381 taacacggtc tgctaattga gcgccagcga tatcaaccat ttttatatta aaaccagctt
     4441 cttttgcttt agcagttaac caatcaccac gaccatttga gactgagttc gaatagataa
     4501 ctaattcttg acttttatca gctttttctt cagatgaaga agcagtcgta gaatttgaac
     4561 ctccagagca agcagcaagt gtagtaagag caactcccgt tgcaagtaca gtagaccaaa
     4621 ctttcatttt tttcatgata agttctcctt ttttattatt ttatttaaat ttttcgtgat
     4681 atggaacaaa ttgtctcata tcttcaaata cagtatagtc aatacggttt acagtaatag
     4741 ttggaatctt ctctaataaa atttcagtta attctgctct gactttagta aactcttctt
     4801 cctcctcttc ggttagagga atccgaagat acccaattga aatatggaat tgatatctat
     4861 catgattagg gaaacaaaca cctgcttttt ctgagacata agtacgaatt tcttctaatc
     4921 tctttgcaga agcttcatct gcaggttcaa ctagtatgtt ttgttttccc atttcagtta
     4981 tacgcatatg aatttcttca tccaacaatg gaaaaatttc aagttgttta gcaaagtaat
     5041 catgtatttc ctgtaaaggt gtatctagag gaagattact gctccaaaac tccgtttcac
     5101 gattttcatg gcacaacaat tcaattacag tcatgtgaat agaattcctt ggagttaaag
     5161 taaacttatc gataaatggt aattctctat aacgtgattg aataatatca acaacttcca
     5221 tcaaatcttg tttagtataa agatttgcta caactgtatt cccagggaaa tgattaaatt
     5281 ccccattctc tttgaactta atttttgtta agtttttcat ataaagacct tcttttttat
     5341 atttgacatc ggtgtcacca tgtttacatt atacaatgaa accgtttcct ttgtcaagca
     5401 cttgcaaaca tttttttaaa tttatctttc attaaatatg catttcatta aaaggttaag
     5461 taatttttcc aaaatacagc actcatatag acagtatcat caattatagc cattgggatt
     5521 ttttgattgc caattccatg tatctctaca catgtcttca atcgattttg ttgtcctcca
     5581 atttaattcc ttatatgctt tgtctgcatt tgcataacaa gttgcaacgt ctcctgaacg
     5641 tcttggaact attttataag gaatagggat cttattaaca ctttcaaatg tatttacaag
     5701 ttgtaataca ctagtgcctt ctcccgagcc taggttatag atataaacat ctgttttttc
     5761 agatactttt tctaaagctt ttatatgtcc tattgctaaa tctactacat ggatataatc
     5821 gcgcacacca gtaccgtcaa gcgtatcata atcatttccg aacacactta gttctgacag
     5881 cttacctacc gctacttgtg caatataggg catcaagttg ttaggaattc ctgagggatc
     5941 ttccccaatc aaaccagact catgagcacc aattggattg aaataacgaa gcaacgcaat
     6001 actccattct gaatctgcca catgaacatc ttttaaaatt tgctcaagca tcactttcgt
     6061 atacccataa ggatttgtcg cacttgtttg catagtctca attagaggtg actgattgtt
     6121 aattccatat acagtcgcac ttgaagaaaa gacaatcttt ttaacattaa attctgacat
     6181 cacttcaaca agtgccaatg tactcataat attatttttg tagtacatca caggcttttg
     6241 cacggattct ccgacagctt tataacctgc aaaatgaatt gcagcatcaa tcgattcttg
     6301 ttcaaatacc tttctcaatg ctggtttatc acaaacatct aattcgtaaa acacgggacg
     6361 tattcctgta attgcttcaa tacggtctag caccaagatg ctagagttcg aaaggttgtc
     6421 gacaatgatg acttcctttc ctaaatttag taattctact acggtatggc taccaatata
     6481 accagctccg cctgttacca atattgccat ttttgtttcc tcctaattaa ttccaaccga
     6541 cttaacaaat ctcataaacg cttcatgccc agacggtgta ttcttataaa ctcctgcatc
     6601 ttccagaact ctcgcaaaca cttgtcctgc ttcgtgttga actacgctat taacctcttc
     6661 tttattaatg cgaggatatt tttctttcaa ttggtcggcc cattctaaat gataatccgc
     6721 aattgcgtta tcctctccta aaagatattt tccaacttct tctaactctg gtttcaaacg
     6781 aggtggtaat atcgcaagtc ccatcacttc gattaacccg atattttcct ttttaatatg
     6841 ttgtacatct tgatgaggat ggaaaacacc atctgggtac tgttcagtag tatgattatc
     6901 tcttagaaca atatctaatt catatctccc gtccacttta cgagcaatag gagtcaccgt
     6961 atggtgtggg acatcttcag tcatagcaat gatgtctact tctaaatctg aatattctct
     7021 ccacttattt agaattttag tagctaaatc taacaagcga tttttatttt cactttgtaa
     7081 cctaattact gacattggcc attttacaat accagcatta acatcctcaa agtctttaaa
     7141 acgaaattca ctctcaaatt ttgctttttc cattgggaaa atatgtttcc ctccctggta
     7201 gtggttatga ctaagaatgg agcctcctga gataggaaga tcagaatttg aaccagcaaa
     7261 atatcctggc aaaatatcaa caatctccaa taattgttca aatgttttag aggtaatagc
     7321 cattggtaca tgttgactat ttaaaaatat cgcatgctca ttaaagtata agtagggaga
     7381 atattggaat ccccatactt cgtcaccaag tttcaatcga ataattctat gattcgaacg
     7441 tgctggataa tttattcgcc cctgatatcc ttcattttcc atacatagta aacatttggg
     7501 ataattagtg gcttttacta atttttcagc agcaattgtt tttggatctt tttcgggttt
     7561 tgacaaattt atcgtaatct ctagctctcc gtatttagtt gatgctcgaa actcaatatt
     7621 cttagcaata gcagaagttt taatataatc actatcttta cttaacttat aaaactcttc
     7681 aactgcttct tgaggtgata tatcatatga actccaaaaa atatcattta atcgactagg
     7741 taaaggaact atgaaattca ttaactctgc tcctaaacat tccttttcct cgattaaatc
     7801 tttaatttta ccgtttttta aggcgatttc cactaagtaa tcttttattt gtttcaggtc
     7861 attttcatcg gaaatgcgat cagttccctc ctcacctatt aacgctagta ctctattttt
     7921 cacatatatt ttgtcaattt cattatacat tccgtattca attactctat caacaaaatt
     7981 atcaataatt gttttcatat atttttcttt ctaatttatg ttcccatatt ttctatacat
     8041 tatccattta taaattgatt gcgtagtatg agcaatttta tcaaggtgat gaataatatc
     8101 taaagcacca attacttcag aaacattccc atcatcttca aatatgtaat tcattatttt
     8161 cttttcaata tttgtactaa gctcttctat ctcattctgt ttttgtataa caaccatatc
     8221 taaacatcca gattgttcct ctctataaca agatatagcc ctattcatat gcagtccgat
     8281 aacttcatga agtattttta tttctgaaat aattttcttc aaaatttcat tattttgaat
     8341 aatctgtaga ttttttaaaa tttcaacaat tctatcccca atacgttcaa tgtcagttga
     8401 tatttttatt acactaataa ttcttcttaa gtcatatgaa acgggatgtt gtaaacaaat
     8461 taactcatat ccttttttat caacatttag aactgactca tttatgatta aatcttcttt
     8521 aatcaattct attcgttctt catttgataa atattcaaat aacttctcat atttatcaag
     8581 cacagatacc caaatggtct ctaaattatt tgataattct ataatttcat tttctaaata
     8641 taaccttaac atttaggtac ctcttcttaa caaagttcaa tagtaacaat taatatttta
     8701 aacaatatat caaacatcaa taactacaat acttgcatca tctttctttc catagattgg
     8761 atcaatagca gaagaattaa atctcatctt aattaactct tcaaaagttt tattttgatt
     8821 attttgatag aattcataaa agccatcgct cattaaaaca atttgttcac tagtaacatc
     8881 tatttgatta ataatagcat ggtctaaaaa tctctcatcc aacgaaccta tccagtaccc
     8941 actcggttga ttagataatt ttctgatttt ttgtaaaata atttttttat ttaaaacact
     9001 atttgtacca attggatctt ttatctcatt tttccctttt tcaaataagt tatctactct
     9061 atgatccgtt atttccattt cgtttactaa catgacgcag tcacctagca tcatatactc
     9121 caactttttt tctgaaagtt tagcaaatat aaaagcaaat gttggtaagc gataatatag
     9181 tatattgaaa ctagaatagt acacctctac ttctaaaaca ttgttagaaa tcgatttgac
     9241 tgtcctgatt gatttgtcct attattattt cattttatta tactctgtta attcatatga
     9301 gtttaaaccg atttcatctt taacctcgag taaagcagtt tcaaatattt gtttaagagt
     9361 ttttgattct ttacaattaa ccgacaaact ttctgataaa atatgtacaa cttctgagac
     9421 tgaataacct atctcctctt tagaattata taaatctgta gctccaccaa taatccaaaa
     9481 atactgattt tgtgaaccta caatatcctc attttctacg gaacttcctt gtatcgaaca
     9541 aattttattt atctttacca taatacttca acccttttag tgtcaaaagt aaaccaattc
     9601 ctgtcactgt taagaatagt tccataatct tgttcgaacc agtctttggt aatttttgtt
     9661 ttacatctac tatttcttta gatttattaa tatgattttc agtttctctg ccatctccaa
     9721 ctattttata gtttacttct tctgtcttat tatcttgttt attgtcgatc ttgtcattca
     9781 tttgtctatt atctttactt gagttaaact ctccgttctt ctggttacta tcaattacat
     9841 tatttgaatt agattgtttt tcctctttgt ttttttcttt ttcgttttta tcacttaaat
     9901 tatttgttac aattttgtaa agcccattct ccgttacaat attgaaatta ccatcgctat
     9961 cacgtataac aggttctttc ccatttgcat tagatttgat gaatgatata tacttaccgg
    10021 ataaattata aaattggtta tttaaaacgg ttattttacc ctttgaatcc tcaataacaa
    10081 ttccttcttt acccccgaat atactattct ctgagactac taaattatca ctaactcgta
    10141 ataattcaat atttggttgt tctgtttcct tagaattatt attaattaca ttttttgtta
    10201 cagtaatatc tgatactttt cctaaatatt ctgcactatc ttttgcaact cgtatcgctt
    10261 ttgttttagg atcggcaata ttaaatatat tttcggcgat aaccacctgt ttatttaaat
    10321 ctaataggtc tttagtgttt ttatagctat aagcatttac taaagctgct ccgctttctc
    10381 gataatgtac actctctcct ttaactttct tatcaaagcg atttcctttg attaatacat
    10441 cagtgaatcc tgtaaaacgt acacctgcat acatcatgtt atcaaaatga ttatttaaaa
    10501 ttttaatatt agaggggttc tgtgtcgaca atgtttgata gtgtgtgcca attgctgtta
    10561 ctaattcccc agatttatca cttttgccaa aataggaatt ttgaatagtc acattttcag
    10621 attttttccc atcatcattc aaggcataag gaaaaccttt tctagttaat ggttcaatct
    10681 gaatgctctc cttacttatg atttgcccat ccttcatcgt tttgggtaag gcttgcccaa
    10741 gaaaacgaga attatcaact aatacatttt tcgaacctgc aatttgaata gcatgccctt
    10801 gataactatc cttgaatgtt acatttttta tagttacgtt atttgaattc ccaatagcaa
    10861 atgcacctga agaatttata agtggtagat tttttgcttt agttccttct tcattcaaag
    10921 caccgttcat atcaatcgta ccaccagaat aactaatatc ttctgttggg ccccattcta
    10981 cttgcgcacc atcatccgta aataaacctg tcataaaaac aatggaaggg tgattcttaa
    11041 tatttatacc atttagaatt gtagctttct cattcaattc taagtgtgta tgacttttta
    11101 aaaaaacaat ttcttttact aaataagttc cttcaggaaa atatacattt cctccaccta
    11161 gcccttgagc tgcagcatct attgcatctt gaattgcttg tcgatcatca tgaatcccat
    11221 cacctaccgc accataatct tttacactta aagcagtatc ttcaaattct tttttgataa
    11281 ttctgtcact tataacatct tccttataac tcttattttc attagtagat gttactgtag
    11341 attcaactgt tctgttgtct aattgtgaat tggaacgaat agtaccatta gagctgatgc
    11401 tattaacact taacgaatta tctaaaccat tagtggttga attagaggca atcatttcag
    11461 cagaacgatt ctgattaaca gttggtgaat tatctaaatc attagtaatt gcattagaag
    11521 actcttttgt agccatcggt gaagaactag taacaacttc atccgataaa ataccttggc
    11581 ttcccaaaat tgaaattgcc aatagtaccg agcaagtccc cacctttaat ttacgaatac
    11641 tgaatacctc attaggaaca aaatatttca tcagaacctc caattttttt actattttta
    11701 acaattgatt attacttttc ttaaaataga tagaatgaca ccgctgtcat tatctttatc
    11761 atatattttc caaattgaat tgtcaaggaa taacacaaga aaatattaaa atttatactc
    11821 ttcggaaatc tcttcaaact aggtcagtgc cgccttgccc taagtctagg ttactgactt
    11881 ggtcagttct atagtagact gaaactataa tagtacacct ctacttctaa aacattgtta
    11941 gaaatcgatt tgactatccc gatcgatttg tcctattctt atttcctttt actatatcta
    12001 caacctcaaa gcagggtttt gagctatcta tggccaactt cctagtttgc tctttagcct
    12061 tccattcaaa agtgatgcta tctttcttag cttgaatata aaatatccca tttactatat
    12121 ttaaatttat tgatatgttg taaattataa atgaaagaac aaataccttg tcatacaagc
    12181 attcgccagg gatatttacc ttaatatcgc tcatatggcg gattgaaact aaaacactac
    12241 aatatatttc ttaaatagac cttctataaa agctagattt aacctcgata aaaatagatg
    12301 cagtgcttct aaaatactgg aatagggcat ataggtaatc gtagacaagt gttttataga
    12361 ttgtctcgca ggagatctaa tgatgtatag caagcatcac taaacatatg ggatatttgc
    12421 gttattataa tatcaacatg ctataaattc tatcatgcaa aagaatgact agaacatgaa
    12481 agacaggcac aaaactttga acaatattct gaaaacaaaa aaaagacgct agtttccaca
    12541 atctcactca tggaaactca cgtctttcaa aaaatagggt gaattgaaaa ctagaacaag
    12601 acactagatt ttctaaatga tgtctagtaa ggattctaaa tgctatacca aattgctcac
    12661 atcttatttc aaaccacggg actcccacaa gaaaggaaaa tcctataaaa attctctctc
    12721 tgaggagaaa gaggcctcaa ctacaggtgt aaactattat caattgaaaa caacagtttt
    12781 tacactcaat tagacttttt aggggcagga tcactttcgc ttgactgtag tttgtcattt
    12841 ttttgataaa gttagcactt tttcagaaac tgttttgaaa gtctcaatga tatagtctac
    12901 ttcttcatcg cttaatttag tatgaagagg gagggtaatt tcattctcaa agaaggcata
    12961 ggccttagga tagttcgtca tatcaaatcc aagattctta taggctgtca agagaggaag
    13021 cggtttgtag tgaacattac ttgcaattcc tgctttagcc aattcttgga tgatgaggtt
    13081 gcgttcttct aggcttgctc cttctacacg ggtgatgtag aggtggcgtg aagattcgac
    13141 agtttcagtc ttgtgtgcca aaggatggat gcgagaagct gcaaaaccac tatcatagcg
    13201 gtccacaatg tccttacggc gttgcaacaa acttggatag cggtccaatt gtaccaaacc
    13261 aagtgaagcc atgatatcgg tcatgttgca cttataggct ggtgtaacga tatcgtattc
    13321 ccatgacccc agttgcatct tggcaagagc atccttagtt tgcccgtgaa gggaaaggat
    13381 ttggaattcc ttgtacatct cttcgtcatc aatcactgga ttggctttcc aagtcgcact
    13441 tccaccttct gccgttgtaa agttcttaac tgcatggaat gagaaggaag taaagtcagc
    13501 gatagaacca gaaggttgtc ctttataaat agatcccaaa gcgtgggcac tatcagagac
    13561 aatgacaata cggttaaagg ccttttgcca cttgcttgaa gcggtaaaga agtcacgttt
    13621 tttctccacg acttggaaca aacggtcata atcgcaaaca atccctgcga gctctactgg
    13681 aataatcacc ttagttttct cagtgatagc ttgctcaagc aggtcatagt ccatctcaaa
    13741 cgtatctgct tggatatcca ccatgacagg ggttgctccc acgtgcgtaa tgacactaca
    13801 tgaagccgta taggtcatgg ctggaacgat gacttcatca ccaggtccca cttccaaaac
    13861 gcgtaaaatc aactccagag cggctgtcgc agagttgaga caaacagtct taggtgtctg
    13921 tgtgtaaaga gacaagcggc gctccagttc ttttgtttta ggacctgttg tgatccaacc
    13981 agaacgcagg gtatccacta cttcagtaat ttctgcttct gtgatatcag gcggtgaaaa
    14041 tggaatattg taatttggca ttgatttgct ccttttatct gtactcattt tcttatgact
    14101 actttatttt agtacctcaa acacggtttg aaacatgatt ttgatgtccc caaagaaact
    14161 aaactctcgg agataggcga ggttatagcg catcttttca ggaagaacat gctccacata
    14221 ggcctgatca actgacagac ctttctccgt catttgactg ataattgtgt cctcatcctt
    14281 gtagttgatg ctggctggag aggtaatccc tgcttgcaag agcaaggttg ccatcatttc
    14341 agggctatac tgctctgtat aacgtggcac ttcaggtcgt gtaccgacaa aggacatctc
    14401 acctttaagg acattgacca actgaggcag ttcgtccaaa cggacacgtc ggatgaaatt
    14461 tccaaccttg gtaatgcggc tatcgttagc agaagtcacc agacttcctt ttttatccgc
    14521 atccgtcacc atggtacgaa acttccaaat cttgaaccga cggttgtact gggtcacacg
    14581 ctcttgcttg taaatcactg gccctttgct atccaacttg atccaaatgc tcaagatgag
    14641 aaagatggga gaggtcagaa ccagtaagac caaggccaaa acccagtcca agcaacgctt
    14701 gaaaatcagc gaacccttcc ttttagagac aagctggtag taagactcaa cctcgcttga
    14761 tttcatttcc acaggcaagt cttcccattt cagcatgctg ttctcctttg tttttattat
    14821 actatttgtc aacatttttc attataccac aaaatggaaa aggcggtgaa agaaatctgt
    14881 aatttgaagg atttccttct agtactcaat gaaaatcaaa gtacagcttt gagattgcag
    14941 ataaagctga catggtttaa agagattttc aaagagtatc ggccatggcc cctgcctgca
    15001 aactatacat cttgtgatag gttactccca gagccaagag ttcctcatgg gttccactct
    15061 cgataatgcg tcccttatcc aagacataga tgcagttggc atcttgaata gtagaaaggc
    15121 ggtgagcgat agcaatagtt gttcggccct gtctcatctt cgccagagaa gcttgaacca
    15181 agctttctgt ttcagagtca atattggctg tcgcttcatc caaaatcagg attttaggct
    15241 ggctggcgac tgttctagca aaggcaagaa gctggcgttg cccagtagag aagctcgaac
    15301 cacgctcgga aacaggggag tcgtacccct gaggaagttc ttgaataaag gaatctgcat
    15361 ccacaaaggc tgccgcagcc tgaacctgct catcactggt ttcttggtac atggcgatat
    15421 tggacttaat agttccatga tagaggaagg gttcctgcaa gaccaaaccg atgttttttc
    15481 tcagctcttc ttgactgaaa tccctgatat ccacatcatc caagagaact ctccctgact
    15541 ggaattcata aaagcgcatg aggacattga taatagacga tttccctgaa cctgtatgac
    15601 ctacaaaggc aatggtttca cccttattaa cagagaaaga aatgtcatcc agaatcggat
    15661 gtttaccgtc atatgagaaa cacacatgtt caaaacggat attgccttct tggactttgg
    15721 cttgcccatt ttcttgaaga ggttcatagg tcctctcgtc tatcagggca aagacacgac
    15781 ctgcagaaac catagccgtt tgcagagttg aaaagttttg cgtcacctca atcaaggggt
    15841 caaaaaggcg gttgatgtac tggataaagg catacatggt cccgaccgtt atcccgatag
    15901 aaaaaccacg gtagccaaag taggccatca agactgcata gcctagaagt ttcagcaaac
    15961 tcatggcagg tctcaaaaag agggcatcca aggctacaga acggttggcg tagaccaagt
    16021 gttcttggtt gatttcatca aattctgcct gcaggcgctt ctcttgatta aaggcctgaa
    16081 taatcctgat tccctcgata ttctctgcca gcttactatt gatatctgac aagagacttc
    16141 tggttttctc gatgattttc actgactttt ttcgatagag attgaccaaa aggaaaatca
    16201 aaggaagaaa gagcaagact aaagccgtca aacgaaaatc cagcaccaac atggtataaa
    16261 gggttgtcag aaagataaaa actgctgaga taaagctgga taaaatccca gaaaacatat
    16321 cactaatcgt ctcggtatcg ttggtcaaac gagaaacgat agaacctgct ggcgtcttgt
    16381 caaagtaaga catgcccagt ttctccatat tggcaaaggc atcccgacga atatccctaa
    16441 caatactgta agacacgcgc gcaaagagaa gattgcctac atactgaact acagtttgta
    16501 ggatgtagag accatagtag accagcaaaa cggtaacggc tagttggtta agattgctga
    16561 gatactggtc gataaagtgg gaagccacga ggggtatgac acttttaatg accatcgtcg
    16621 ctaggagaaa actgagtgcc aaaaaggtca ggagtccata aggcttgaga taagacatca
    16681 agcgcttcaa tacagcccat tgttcttgtt tattctgcat cttcttctcc tttcatttcc
    16741 aactgctgag actggtaggt ttgggcatac cagccatcca tcgctagcaa gtcttcgtgc
    16801 gtgcctcgtt cgataatttg accattttgt agaactaaaa taaaatctgc atggacaaca
    16861 gcactgaggc gatgggcagt gataatggtt gtcttgtcct ttcgcgtctc cttgaggttg
    16921 tcgataatcg catactctgt cttggcatct acggcggata aggaatcatc caaaatcaag
    16981 atatcagggt ctaaaatcat agcccgactc atagccaacc gttgcttttg accaccagaa
    17041 agactgactc ctttttcacc aatcagcgta tcaaatcctt gaggcatgtc tacaatatct
    17101 tggtaaactc gggctagctt agtagcttcc tcgaccgctg aaaggggcaa gttaggattg
    17161 ccaaagcgga tattgtctag gattgaagtc gcaaagagaa actggtcctg aggaacatag
    17221 cccatgagac tgcgaaggtc tgtcagacga tagtcccgaa tatcgtgacc gtttagataa
    17281 atagtaccct tatccacatc gtattcacgc aagaggagct tgattaagga cgttttccca
    17341 gagcctgtct gcccaaccaa gcccagtgtt tgcccttttg ccaaactaaa gtgaatatcc
    17401 gtcagtgttt cctcattttc aaaagcaaag ctgtcaatgg catactccaa acgcccattt
    17461 tcaataccat ccagaggaaa ctcagggtct tgtacaggag attcctgaga caaaagattt
    17521 tcaatccgct ggtaagaaac cttccctcgc tgagtagtat taaagaggaa accgatggcc
    17581 agaagaggcc agaccagcat atccaaatag ctgataaagg tgactagatt cccaactgta
    17641 atctgccctt cctgaaccat caaggagcca accaaaagcg ttaaaacata ggacgaacca
    17701 acaaacaaga gaaccatagg gtcaaagaga ctatcatatt tcatggtttg caggttcttt
    17761 tggaaggtta attcattgac tgcctgaaaa gacttcaact cgtctgcctg ataaccgaaa
    17821 gacttggtca ctttgatacc tgatacggac tcctgtacct tgttattgag ttcagaaaaa
    17881 gcagcttggg attcgccaaa ggccttatga gtctttctcc ctaggcgact agtcgtatag
    17941 gccatgaaag gtagggggag aatggcaaca agagtcatct gccatgagat gctaaagagc
    18001 atggtcaaca aagtcaccag agccgtgata gaggcatcca ccgcagacat gacaccgcca
    18061 cctgctaaac gagtcaaggc attgatatca ttggttgcgt gtgccatcag atcacccgtc
    18121 cgataggttt gataaaaggc tgacgacatt tttgtgaaat gcttaaacaa gcgagaccgc
    18181 atgatctgtc ccaagcaata agaggtccca aggatataca tacgccacac atagcgcaaa
    18241 tagtacatac caaaggctgc aagtagcaag taaaataggc taagaaggag gtcctgctga
    18301 gttaattgcc ccgatgtgat ggcatcaatg actcgcccca taaccatagg aggaatgaga
    18361 ttgaggacgg aaaccaagac cagggccaca atcccgacta gataacggcg tttttctaac
    18421 ttgaaaaacc accagagttt ttgaataatg gacataaaat ccctttctga ttgcaaatgg
    18481 aaacctgagg ccaatactca atgaaaatca aagagcaaac taggaaacta gccgcaggct
    18541 gctcaaagca ctgctttgag gttgtagata gaactgacga agtcagtaac ctacatacgg
    18601 caaggcgacg ttgacgcggt ttgaagaaat tttcgaagag tacaagaccc caggtttttc
    18661 ttattcataa gttacgactg taacagcacc cttgtcatat tcagcaataa agatattggc
    18721 tacattgtca tgcccttgtt tactgaggtt atcaagcaac cactcttcgc tacgaccaat
    18781 cgattccaag acatctactt gaatcacacc gtctgtcaca actggatact taggattttc
    18841 atctcccatt tgcacaacga tgagttgccc attttgctct tgcacagctc gtttgacttg
    18901 cttcatctgg aaaatccctt ggctacgaag tttgagggct acatccgatg cagacaaacc
    18961 aactgaacga caggcttatg ggtcaatatt cccatttttg ataaggagag ttggcttacc
    19021 atcaatcaaa cgtttcacaa agtgaacatt gttgttgagc tatttgaaag tcaagatcag
    19081 tttgattaaa atttcgatat aattaagtgt catttgttca catccaccag ttcaattgcg
    19141 tctgtcttat acaattcgac tttctctaac aggtacttgt ctggctcact tccgtttagg
    19201 gcacgataat agcgatctcc caccttgata agtgcgccat ctgtgtttgt ggaagtatta
    19261 acatagactt ctgacttgtc tactcccaaa tctttggaaa caacctcgat gaaatgaagt
    19321 gaagtttgaa atttattgtt agaaacttga ttgttttgat aagtcgtgat gctgaccaaa
    19381 agcagagcta aataaggcca gagctgaaat catgaccaac tcacgaaatt tggttccttt
    19441 tttatcatgg tatgccttga aagcaaaaaa aaactgtcac agctaataga acaatcccaa
    19501 agccaaccat gataccattt tgctgaccga tttggctgag tacatagtca taagagtaga
    19561 atttcatgta ttttcactcc ctttcataaa atcattctta attataaacg aaagagagta
    19621 atttttcaaa ccatacgttg gggaaataga tctttttttg gtataataaa atctataatc
    19681 tgaatgaaaa aggtaacttt atgaaactta tctcatggaa tattgattcc ctaaacgctg
    19741 ccctaactag tgactcagct cgtgccaaat tgtcccaaga agtcctacaa accttggtcg
    19801 ctgaaaatgc tgatatcatt gctatccaag aaaccaagct ttctgccaaa ggacctacaa
    19861 agaaacacgt ggaaatttta gaagaactct tcccaggcta cgaaaacacg tggcgctctt
    19921 cccaagagcc tgcccgtaaa ggctatgctg gaaccatgtt cctttataag aaagaactta
    19981 cacccactgt cactttccca gaaatcggtg ccccttctac catggacttg gaaggccgca
    20041 tcatcactct agaatttgat gcatttttcg taacccaagt ttacactcca aacgctggtg
    20101 acggtctcaa acgcttggaa gaacgccaag tctgggatgt taaatatgct gagtatttgg
    20161 ctgaactaga caaagaaaaa ccagtccttg cgaccggtga ctacaacgta gcccacaatg
    20221 aaatcgacct tgcaaatcct gctagcaacc gccgttcacc tggatttact gacgaagaac
    20281 gtgctggatt taccaacctt ttggcaactg gatttacaga caccttccgc catgttcatg
    20341 gcgatgttcc tgaacgctac acttggtggg cacaacgcag caaaacttct aaaatcaaca
    20401 atacaggctg gagaatcgac tactggctca caagtaaccg tatcgctgac aaggtcacta
    20461 aatctgatat gattgactca ggtgctcgcc aagaccatac accgattgtc ttggaaattg
    20521 acttgtaagg attttctata tggactacaa tgcggtcatt cccgagttgc ttgtatcgaa
    20581 tatcgaacag tcccggtcct tctactgtgg tttactgggt tttaggattg aataccaacg
    20641 tccagaagaa aactttctct tgaagagtgt caactaatgt tagaggaggg aacaaaggat
    20701 caactagctg aactgaccta cccctttggt cgtggagtca atctctcctt tggcataaag
    20761 gatgttccaa aactctatta aagagtgatg aaggcaaact atcctattta tcgtcccttg
    20821 accaaaagaa agtttcgtgt cagtgatccc tatatctatc ctcataaatt tgcagttttg
    20881 gatccagatg gctatttttt aagatttagc gagtagaata ataaaaattg ggaaaagtct
    20941 ttaaagttag aaaaaggcat attgtcaggt gtctaaaaac ttgatagtat gccttttatg
    21001 atggaaaaat cttctaatac tcttcgaaaa tctcttcaag ccacgtcaac gtcgccttac
    21061 cgtaggtata tgatactgac tctgtcaatt ctatccacaa cctcaaaaca gtgttttgag
    21121 gttgtggata gcttcctagt ttgctctttg attttcattt agtataaatg ttagcttaca
    21181 atggagtttt tgttcacccc ctcttctgtt tgttcgtttt ttaaatcaaa acactaacaa
    21241 aatagttgat ttataaagtt atttagtgta aaataaaaac attggctcaa gcctatttaa
    21301 aattgaatat cgttttactt gtttatgtcg tgaattggca cgacgtttct acaaggtgcc
    21361 ggaacaccta acaataagta agtcagcagt gagatatggt cgtttttgcc atgcctattt
    21421 gggggactta cttagagatt aagtaggtcc tttttgaata tttttaatat ttcccttaat
    21481 tagtgcggac gggaggtgaa attatcctgt gaataatttc aggaattcag ggaatttcat
    21541 ccctaatttt tgagccccta gctctttcat ttctaggctt aggctaaaat agttccccga
    21601 actattttac tctcaaaaat cccgtcatag acaataacaa gattattgtc tatgatacca
    21661 ctacatcggg aaatatttga taagactatt acgagcgaag cgagtcttat caaatatata
    21721 gtattagcaa aagggatcac tatagaaaca tttcaacaac aagtaaatta gcttttagac
    21781 tttaggaggt cttatgaaat tattagaaga tcgcatcctc aaggatgggc atatcttggg
    21841 tgataacatc ctcaaggtag attccttttt aacccaccaa gttgacttta gcttgatgcg
    21901 agagattggt aaggtttttg cggaaaaatt tgctgctgcc ggcattacca aggtcgtaac
    21961 cattgaagcg tcgggtattg ccccagccgt ttttacagct gaagccttaa acgttcccat
    22021 gattttcgcc aaaaaagcta agaacatcac catgaacgaa ggcatcttaa ctgctcaagt
    22081 ctactccttt accaagcagg tgaccagcac tgtttctatc gctggaaaat tcctctcacc
    22141 agaggacaag gttttgatta tcgacgattt ccttgctaat ggccaagctg ctaaaggctt
    22201 gattcaaatc atcgaacagg ccggtgccac agtccaagct atcggtatcg tgattgagaa
    22261 atccttccaa gatggtcgtg atttgcttga aaaagcaggc taccctgtcc tatcacttgc
    22321 tcgcttggat cgttttgaaa atggtcaggt cgtatttaag gaggcagatc tctaatgcaa
    22381 actcaagaaa aacactcgca agcagccgtt ctgggcttgc agcacttact agccatgtac
    22441 tcaggatcta tcctggttcc catcatgatt gcgacagccc ttggctattc agctgagcag
    22501 ttgacctacc tgatttctac agatatcttc atgtgtgggg tggcaacctt cctccaactc
    22561 caactcaaca aatactttgg gattggactc ccagtcgttc ttggagttgc attccagtcg
    22621 gtcgctccct tgattatgat tgggcaaagc catggtagtg gcgctatgtt tggtgccctt
    22681 atcgcatctg ggatttacgt ggttcttgtt tcaggcatct tctcaaaagt agccaatctc
    22741 ttcccatcta tcgtaacagg atctgttatt accacgattg gtttaacctt gatccctgtc
    22801 gctattggaa atatgggaaa taacgttcca gagccaactg gtcaaagtct cttgcttgca
    22861 gctattactg ttctgattat cctcttgatc aacatcttta ccaaaggatt tatcaagtct
    22921 atctctattt tgattggtct ggttgttgga actgccattg ctgctactat gggcttggtg
    22981 gacttctctc ctgttgcggt agctccactt gtccatgtcc caactccact ctactttggg
    23041 atgccaacct ttgaaatctc atctattgtc atgatgtgta ttatcgcaac ggtgtctatg
    23101 gttgagtcaa ctggtgttta tctagccttg tctgatatca caaaagatcc actcgacagc
    23161 acgcgccttc gcaacggtta ccgcgcagaa ggtttggccg tacttctcgg aggaatcttt
    23221 aacaccttcc cttacaccgg attttcacaa aacgttggtt tggttaaatt gtcaggcatc
    23281 aaaaaacgcc tgccaatcta ctacgcagct ggtttcctgg ttctccttgg actgcttcct
    23341 aagtttggtg cccttgccca aatcattcca agctccgtcc tcggcggtgc catgctggtg
    23401 atgtttggtt ttgtatctat tcaagggatg caaatcctcg cccgagttga ctttgctaac
    23461 aatgaacaca acttccttat cgcagctgtt tcaatcgctg caggtgtcgg tctcaacaac
    23521 agtaatctct ttgtcagcat gccgacagcc ttccaaatgt tcttctcaaa cggaatcgtc
    23581 gtagccagcc tactcgccat tgtcctcaat gccgtattaa atcataaaaa gaaataagaa
    23641 aaagaggtgc gagcctcttt tttgtgtgac aaaataaaaa catctaccta ttcatatatg
    23701 ctagtgtcat agtcctgaaa atcatctgca tcaagaacaa tttcacaact cttatacttt
    23761 tctcttacaa gtcgttcggc ttcatctgga ttttcagcct ctatacttac taaacgtgat
    23821 aaagtttctg taatttctac tgtatacttt ttcagtttta gattgctttc caataattca
    23881 cctattaaca ataatctatg ataggagcta tgtagccact ctggcaattt atctcctact
    23941 tcccacccat atttttcctt catcaaagct agttgttttt cgtcaccaaa tttcatattt
    24001 tcagataacc atctcacaca atcgggatct gataaggtac agacgattaa acttaggtta
    24061 tcgtaacggc tttcagtttc ataatcaggc cagatgactt ttaagaaatc atacacctct
    24121 tctgatgcaa caagttgttt cgttttcata atttccgata ctttcctcta cctttaaatt
    24181 ctattatttc tttgtctctt aatatttgaa gctgttgcct aatcttttct ttgatatgat
    24241 tgttcttaac aaagatattt tttaggtcac tttcaaaacg atacatatct tcaagggtaa
    24301 attctgaacc ctctatctta tctatacaat ttagaatttc tattgtccaa cctcttgatg
    24361 acagagagct cttccttaaa aataaacctt gcttaaattc ttttgtaact ttttctggat
    24421 ctctaacttg tccatcttgc acaagaaata tccttccttt agaaggtact tgtgataaat
    24481 caatgttaca accaatccaa cctgctcgtc tagcagttgg tgcaagtggt tttctttgaa
    24541 taatcgattt cggtgtaaca aattgcttcg gaaggacaag aaagttattt acctcaaaat
    24601 tttttgtgta agttaaaaaa aagaaattag gattattatc tgcctgcaca cgcttcatca
    24661 tcgttgcata agcaccatca ttgattgttg atgaaaaatt tccttttttg ctctttagtt
    24721 caaactcctc actacaatga ttacagtaaa aatctgctac aggccgatta ttttcaaaat
    24781 gatttaaggg attgttccca caattagggc aataagactg acgataaacc caatcctccg
    24841 ttaagatacg tgccttttgg ctattacttt tataggtttc tactaattct aaattaaagt
    24901 gtaattccat ttaaaaattc ctcactaata tgagaactca ctcgatataa gcaattaaaa
    24961 tctactataa ctagtatacc acatatatgt acctattaca tttgtatttc atcactctct
    25021 tttatatttc cttctaacat atctcataaa ttaaaaatga gtgagataaa tttatcccac
    25081 tcacctttct ttatatactt acccgtcttt cctcagacct ttggcctgtg acaaacatgg
    25141 taaaggttgc tttacagaca tttctgccct cttgattggt gatatccaca tccatcacac
    25201 aggttgtacg accttgatgg acacattctc ctttaatggt caatacatcg tcgagttttc
    25261 ctgccttaag gtagttgata gaggattgga gtgtcacccc atcaagtccc agcgagataa
    25321 ccaccaaacc actgatttgg tcacatagcg tgaatagata gccaccatgg gcattgccat
    25381 agtagttgag cgacgagttc actactttgg tcgtcaccac aacgtgacca tctctcattt
    25441 tttcaatttc gtaattttca aaggcagata tagcgtcaaa atgaaagtct ttcatcgttt
    25501 cctcctgata tttcaaacga cactatgata ctacttttta taggactgtg caaggagaaa
    25561 gctcctagtc tagtaaaatt ccgacatgtt ccacaaagcg cataaaggct gtctgccctt
    25621 gttctgtctg cttgtagact cctgcatcct caagtacacg cgcaaagata gcacccacag
    25681 agtccttgac gattgcaagg gctttttctt tatccgttag gtctggatgt tgggatttga
    25741 gttggtctgc ccactcctga tgataatcgg caactgtaac agcttctcct acaagatagc
    25801 tcgcgacttg ctccacttct tctttcagac gtggtggcaa gattgccaag cccatgacct
    25861 caatcaagcc gatattttcc ttcttgatat gttggacatc cttgtgggga tgatagatgc
    25921 catcaggatg ctctgctgaa gtctgattgt ctcgcaagac caagtccaac tcaaactgtc
    25981 catcacgctt acgcgctatt ggtgtgatgg tgtgatgcgg tgtcccgtct gtctctgcta
    26041 aaatctgcac actagaatct gaatactgac gccattcctg gaaaatctta tcagctaagt
    26101 taatcaaatc ctctttggaa tccgaagtca agcgtaggac agacattggc cacttgataa
    26161 ttccagcctt gacctgctca aaaccagcaa atcggaaggt cttttgcaag ggagccaatt
    26221 ccataggaaa tacgtgacgg cctccctgat aatgatcgtg agttagaata gagcccccca
    26281 caatcggcag gtcggcatta gatccagcaa aatatcctgg aaactgctct acgatagcca
    26341 acagacgttc aaaactctga cgactaatgg ccatgggacg atgctggcca tctaaaaaga
    26401 tacaatgctc attaaagtaa gcatagggcg aatactggaa cccccattcc tgaccaacca
    26461 tttcaaaacg gataatccgg tggttgctgc gagctgggtg gttgacccga ccatggtaac
    26521 cctcattctc taaacaaagt tgacactgag gataattact agcttgcacc aacttggcta
    26581 ccgcaatctc tttcggatcc ttttcaggct tagagagatt gatggtaatt tcaagttctc
    26641 cataatcaga tggaacacga taagcgatat ttttagcaat ggccttgagt ttgatgtaat
    26701 catttttctg actgagttga taaaaatcct ctatcgcttg ctcaggagag tggacatagg
    26761 cttcccagaa gtcacgattg acctgactcg gataaggagt caccaagtcc atcagttcag
    26821 taccaaggat ttcacgcgca gtctgactat cctcaatcat ctctaatcga acggcttcct
    26881 caactagctg gtccttgagg tcaatcaatt tatccagatt ggtctcaact tccaaaacac
    26941 cttctcccac tcgtgccaaa acacggttgg tcaggtagat tcgatccatt tcctcaaatg
    27001 aactttcaga aatgacatgt gttacaaatt tatctactaa gatcactata gagcctcctt
    27061 ttgactagtc aaggacgcga gtgccacctg caacttcagc gatatagaag cttggagcgt
    27121 atccaactac ttcctcgtag tgtttgccta cagcttcctt aaaggcctca acagtatctt
    27181 tttgaaccaa ggcaatggca cagccaccaa aaccagcccc tgtcatacga gcaccgagaa
    27241 ctccttcttg tgcccaagct gtgtgaacaa gagtatccaa ttccaaacca gttacttcat
    27301 aatcatgctc cagagaaacg tgtgacgcat tcatcaaacg accaaatgtt tccaaatcac
    27361 ctgcttgaag ggctgcttga gctttaaggg tacgttggtt ttcaagcaca gcatggcgag
    27421 cacgtttcaa acgattttca tctttaatca aatagctata ttggtcaacg gcccactcgt
    27481 ccaattcacc cagggtctga atatccaagg caacttgcaa ttcttccact gctttttcac
    27541 actcagcacg acgttcattg tatttagagt ccgccaattc acggcgtttg ttggtgttca
    27601 tgataacaac gacattgtcc ttcaaatcaa gtggcaccaa gtcgtattct aaagtattgg
    27661 tatctaagta aatagcacgt tggtcagccc ccataccaat agcaaactgg tccatgatac
    27721 cagagttgac tccgataaag ttgttttctg tttgttttcc gattttaacc aaatccaaac
    27781 ggtctagttt taaatcaaag agatgctctg ccacgactcc tgtcaagagc tccaaggatg
    27841 ctgaagaaga caaaccagca ccatttggga tattcccata aacataaaaa tcaaaacctt
    27901 tgtcaatcac gtgcccagct tcttgcaaga aatgaagaac cccttttgga taattggtcc
    27961 agttgtgctc tttttcaaac ttgaggtcag cgagaggcac ttcgataatg cccttgtcct
    28021 caaagttagc tgagtagaaa cgcaagactt ggtcgtcacg cttacgagct gcaccgtaag
    28081 ttcccaagga aatagcagca ggaaaaacgt gcccaccgtt gtagtctgtg tgttcaccaa
    28141 tcaaattaat acggcctggt gaaaagaagg tttggtctgc ttcttgacca aaaacagcaa
    28201 gaaagtcttt gcgaaggact tcagtagtaa gatgttgtgc catatgaatt ctcctttgac
    28261 tgtccgttaa gccatcttaa cgtgtaatcg ttttctttct attgtatcca aggaatttcc
    28321 caaggtcaat cctttttact aaaattttac taaaatatca gtaaaaagaa gaaaaatatg
    28381 atatactaac ctaatcaagg aggatttatg gctaccttaa aagacattgc acagctagcc
    28441 tctgtctcaa tcgcgaccgt atcccgtgtc ctcaaccgcg accagagcct atctgttaca
    28501 gaagaaacca gacaccgtat tttaaccgtt gctgaagagc taggctacac caaacacctc
    28561 aagacaggcg agtcccacaa gcccaagcaa aagattgcca ttatccaatg ggtcagcgaa
    28621 caaggggagc tagacgacct ctactactac cagattcgcc taggaataga aaaaagagcc
    28681 caagagttgg actacgatat cttgcgctat tttaatgacc atccttttac cttaagcgag
    28741 gaagtgattg ggattctctg catcggaaaa tttagccgag ctcagatttc tgcctttgaa
    28801 gaataccaaa agcctcttgt atttctagac agcgatacac tttccctggg acatacctgt
    28861 attatcacgg atttttacac tgctatgaaa caggttgtcg attatttcct cagtcaaggg
    28921 atggaccgca tcgggattct aacagggctt gaggaaacaa cagaccaaga agaaatcatt
    28981 caggacaagc gtctagaaaa cttcaaaaac tacagtcaag cgaggggaat ctatcatgat
    29041 gaactggtct ttcaaggaag atttactgcc cagtctggct atgacttaat gaaggaggcc
    29101 attcagagct tgggagacca acttccgcca gcatttttcg cagccagcga tagtttagct
    29161 atcggtgctc tccgtgccct ccaagaagct ggaatcagcc tgccagatcg cgtcagcctc
    29221 atttcattca acgacaccag tctgaccaaa caggtctatc ctcccctctc tagtattaca
    29281 gtttatactg aagaaatggg gcgagcaggt atggatattc ttaacaagga agtcctccac
    29341 ggtcgcaaaa ttcctagcct gaccatgctg ggaaccagac tgacattaag agaaagtacc
    29401 ctaaatcaag aataggataa cataaaaaac gaatagagtt ctaaaactcc tattcgtttt
    29461 ttattcgatt acaatcatag acttaatggt cttacgttca tccatatctt tgtaggcttg
    29521 gtcgatatct tccagtttat aacttgaagt aaagacgcga cctggattga tatcaccatc
    29581 aaggacggct tttagtaaaa attgcttatc gtatgttgta gcagaagctg ccccacctgc
    29641 tacagagata ttttgcataa atgtcgaacc aagagcacga ttattatagt gtgggactcc
    29701 tacaaagccc atacgccctc cattatgaag aacacctagc gcctgttcta tagcagcctc
    29761 cgtaccaaca cattcaagtg ctgcgtctgc tcctccaccg aggatttcac gcaccttggt
    29821 aattccttct tgaccacgtt ctgcaacaac agctgtcgca cctgactcca tagccatctt
    29881 ttgacggtct tcatgacggc tcataaggat aatttgtgat gctccacgca tcttagccgc
    29941 gatgacagca cattgaccaa cagccccatc accgataaca acaaccttgt cccctttttg
    30001 aacatttgca acacgcgccg catgatagcc tgtcggcatg acatctgcaa gagtcaaaag
    30061 ggacttgagc atcccttctg tatagtcaga aggttgacca gggattttaa ccagcgccca
    30121 gtttgcatag tggaagcgaa tatattctgc ctgaaaatca ccccccaaat tattgccaat
    30181 atgattgtcg caagaaccgt caaatccagc aagacaggca tcacactcac cacatccatg
    30241 tgtaaaaggg acaatcacaa aatcacctgg tttcaccgtc gtaatggctt ccccagcttc
    30301 ttcaacaatc ccaatcgctt cgtgtccact atttttgtgt ccagctttcg tttctggatt
    30361 acggtacctc cataaatctg aaccacaaac gcacgcacga accacacgaa taatcacatc
    30421 atccgcttct attatttgcg gacgttcaat gctagcaagt ccaacctgac ctgcctttgt
    30481 atatactgct gatttcattt aaaattttcc ttccttataa agtttaattt tgagatttaa
    30541 acgatttaaa gctgtctgta gctgagacaa gcgctcctct aatttttgct tttcctcttc
    30601 taaaatacca agcctctcct ctctcgtttc atctcccttt tggtagagcg acatatagtc
    30661 aactaaacta tctacagaga cacccgccga acgaaaacac ttaataaatt ccagcgcttc
    30721 gatatcctga tcttgaaaat cacgaatccc agtagcagta cgagtaatcg gtggcacaag
    30781 accaacccgt tcataatacc gaatcgtatc cgctgaaatt cccaacaaat cactggcaga
    30841 tttaatattc acacgctaac ctcctctcat ttcattcact gaattcacgc tattctaact
    30901 cacttatctt attatataac tttgagttga ctccaagtca agcattttgt atctaatcga
    30961 aaaattttta tcattaacaa tcatatatct ggagtttata caatgctctt ctcttaccaa
    31021 tttttgaaat atttaaataa taaagaaatt actctattcc aaataagata gtacccaagt
    31081 atttttcact tttttctaat gttgatgctc ataactccgt tccaagtcac acacctttcg
    31141 cttatgggtt tggtgagttt ctaggtcagc atcaatttca atggtaatat tttgaaaacc
    31201 acaatctttt aggaaaattc gaatagactc tttacaagtt tccatatgtt ccatttcttt
    31261 tagacaaaca tggacaatgg catttttttc caaagcatcc atagtccaga gattaagctg
    31321 attaaggctg gccacattgt ccaatcgctc caggccactc tttacttgct tgatatcaag
    31381 accttctggc acagcatcca agaaaatctt gagtgtagac caaaaacgtg gaagggcttt
    31441 tgaaagaata aagaaagaaa tgacaaggga caaaagagga tctaggatat accagtccgt
    31501 aaatcgaaga acaatcgcca tcaggataac agctacccac cctagcgtat cttccagaaa
    31561 atgcagactc agaatagact cattctttgt ctttccctta ccaaccacca gactcgctaa
    31621 cagattgata gtaatcgcaa taattcctaa ccagagaatc ccctcatcat tgactggttg
    31681 cggatgcaaa atcttcgtga cattttccaa aatgactaga acagagcccg ttacgagaat
    31741 cacagctgtt accaaggctc ctagcaggct aaaccgctta tagcccaagg tgtactgatt
    31801 gtcttcttca cgattggaga ttgtttctag aaaagctgat attccaattg caatcgcatc
    31861 tcccaagtca tgcacagagt cagcaagaac agcgctagaa ccaaatactc cacctgcaat
    31921 aaactcaaca atggcataag tcaaatttaa gaaaaaagcc acccaaacag catattttgc
    31981 cttcatattt ctcattcctt tgttataata gatttatgaa caccttgttc attatcatta
    32041 tccactaaaa ctcaaagaaa ggatagaagc aaaacgtcag ctttattcag ttctgaacaa
    32101 tttgcctcaa gtgtccatat gactaacatt gaccgccgta tcagcaaaac caaaaaagcc
    32161 atctatcaag cttttataca acttttgaat gctaagggct acgaggccac tactgttcag
    32221 gatatcattg atctcgcaga tgtgggacga tccacctttt actgtcacta tgagagtaag
    32281 gagcttcttc tggaccagct ctgccgctac ctcttccatc atctttttga aagagagcaa
    32341 gccatttcaa ccgaggacta cctcgcccac ctctttctgc attttcataa aaaccaagac
    32401 catatcacca gtctgctatt ttccaaaaat gactacttcc tccgtcaact ccataaagag
    32461 ctagaacacc atgtctattc cgtgctagct gataatttaa aagaagccca ccctaatctg
    32521 cctacttctt acctccaaca cttggtcatg tccaacttta tcgagacatt gacctggtgg
    32581 ctcaaaaaag gtcaagattt cacagaccag gaagttgtcc aattttatct agaccttctc
    32641 attcctaaaa attgaatata gagtaaagct cagttgtctt atttctagat tactgagttt
    32701 tttatctttt caacaacaaa agaggacccg ccgatcctct ttttcatact ataaatcctt
    32761 gattatcaac tatatctgtt ttaatcgaaa tctcaaaaca gcactttcaa acatcttttc
    32821 ctagttaagt aaatcagtat tctgcttagc tgccttgctc cattgatacc aaccaactag
    32881 actgttaatg agataaatta gatatttccc ttgaatttgc aggctttctc cccaccagag
    32941 atagattgaa aagacattgg tagccgccca gaatatccac tgttcacggt aaacagctgt
    33001 catgaggatt tgccctaccc cattggttgc atctgtgatt gaatcacgat agggacgatt
    33061 ggcaccaata gactgataaa tgaagccaaa ggccaaccac caaagcacac taatggaaag
    33121 atactttgtc cagcccttgc cgtccagttt acgcgcgaca aactcctgct tttccttctt
    33181 aaactgtgcc tgataaatcc aaactagaag tccaattggc tgcatgactg tgaagtaaag
    33241 tgtcgtcagc acctcaccat aaaagccttt ctgtagggcc aaaataaggt aaataacaga
    33301 gttaatcaag ccaaaaagat aattacttgc tcgaccttcc gatacaaaga ttacacagat
    33361 aatccctgtc aagctacaaa tcatcccaat ccagtcaaca atacgatgtt cgtaaaccaa
    33421 ctccagccag agaggaaaac ttcctaaaac cagcaaataa atccactggg caaaactacg
    33481 atgggcaaag aggtcatccc agatagcctt catagttcct gaaaatccta aatcagccat
    33541 agccgcaacc atacgacggt aaccacctga catttcacct agggttgttt tgatattttc
    33601 aattttcttt tgcaaataag tatgcatcat ttctcctttt gtttttaaag agccgtgtct
    33661 ggatagactt tcggacgcaa cgctctatta gataatgaac tgcctataca caagatttct
    33721 aaccttagtc gacatgagct gaaacctctt atttgttaag tagttcacaa aatattatac
    33781 acctatttta tgaatagtca actgtcttta cagtaaaatt ttagaaaatc atgaaaattt
    33841 tctctttctt tccattttaa gtgacattca gtcattctca catcaaaaaa gcccagacga
    33901 aattgtctga gcattctttt atctagtcgt ttaaggaagt tgagttcagt atgtttaaag
    33961 tctctgtccc atcatttctt caacaaacct tgttcttgga gaaactcctt ggctacttgc
    34021 tctgctgact tgccttcaac accgacttgg tagttgagct ggctcatctg gttttctgta
    34081 atcttaccag ccaatgtatt aagaactctt tccaactctg gatgtttctt gagaagagct
    34141 tctttcatga gtggagcccc ttgataaggt gggaagagtt gcttgtcatc ttccaagacc
    34201 tgtaaatcat aacgctccaa ttccgcatca gtcgaatagg catccgtgat ttgaatatcc
    34261 cctgactgaa ttgcctgata acgaagagct ggctgcatag tcgccacatt gagattgaga
    34321 ccatacattg attgcaagcc cttatttcca tcttcacggt cgttaaactc aagcgtaaag
    34381 cctgccttca gctgcccttc cacttttttc aaatccgaaa tggtcttcaa gccatattct
    34441 tgagcaatct ttttcggaac agctacagca taggtatttt gataagacat aggtttgaga
    34501 taggctagat gatcctgctt ggcaatgcca tcacgcgcca cttgataaac ctgctctggc
    34561 tcatgactca ccttgggtga tggttgaagc aaactttcag tcaccgtacc ggtaaattca
    34621 ggataaatgt caatatcacc ttttttcaga gcttcataaa ggaaacttgt cgtcccaaaa
    34681 ttcggtttaa cagtcgcagt catgctggta ttttcttcaa tcagcaattt atacatatta
    34741 gccaaaattt ctggttctgg gcctattttc ccagcaataa tcaagttttc cttctctttt
    34801 tgagccaaaa gggctggact ataagacaga cccagtaata aagccaccaa ggcaaaacca
    34861 gagaaaatcg tccgcaattt cgctttttcc attactttta gtaggaagtt aaaggcaata
    34921 gctagcactg cagaagaaag tgccccaatc aaaatcagac tggcattatt acggtcaatt
    34981 cccaaaagga taaaggaacc tagtccccct gccccaatca aggtcgccaa ggtagccgta
    35041 ccgataatca agaccgctgc cgtccgaatt ccagacatga taacaggcat ggcaagtgga
    35101 atttcaaact tcttgagacg ctcccatctg gtcatcccaa aggcaatccc agcctcttgc
    35161 agactcggat caattccatt cagcccagta atagtatttt gtaaaatcgg aaaaatcgca
    35221 taaatcacta gagctgtcaa tgccggtaaa gtcccaattc ccatcaaagg gataaagagc
    35281 cccaacaagg ccagagacgg gatggtctgg aaaatacctg caatctgcaa gacccagtcg
    35341 gccagcttct catgatagcg aagataaaca gccaagggaa tcgcaagcaa aatagctagt
    35401 aacaaggtca aaagtgacaa ctgcaaatgt tgagataggg ctgtcaacca atcaccaaaa
    35461 cgatcctgaa aagttgcaat taaattagtc atgaatacta cctccaaaca agtctgcaac
    35521 aaagtctgtt gcaggagctt ttaaaatagt ctcaggattc gacacctgac gaatctctcc
    35581 atcctgcaag acagcaatac gatctgccaa ctttaaggct tcatccgtat catgagtcac
    35641 aaaaatcgtt gtcatcccaa actctttatg taattctttt gtcagaacct gcaactgttt
    35701 tctcgaaata gcatccaagg ctgaaaaggg ttcatccatg aggagaatct tgggctgacc
    35761 aatcatagct cggacaatac cgacccgttg ctgttctcca ccagatagct cacttggaag
    35821 tcgatgccca tactcagcta ctggtaaacc aaccttagcc aaaagctctt ctgttttttg
    35881 agcaatttct tccttagtcc aacccttcat ttcaggaatg agagcaatat tttcctcaac
    35941 tgttagattg ggaaagagag caatagcctg taaaacatat ccagtagaaa gacgaagttc
    36001 acgctcatca tagtctttga tgcgcttccc atccatataa atatttccat cagttggttc
    36061 caaaagacgg ttaatcatct tgagcatggt cgtcttacct gacccagaag gccctactaa
    36121 aaccataaat tccccatcct caatctgtaa gttgacatct ctcaagacat ccttttctgt
    36181 gtagcgcagt gctacatttt tgtattcaat cattctttgt cctcaattta aaacttccct
    36241 cgattagtca agtcttctac cttaggcatg acttccttat tatcccaatg ctccacaatt
    36301 ttcccgttct ctaaacggaa gatatcgtac tgggcataag caacgccatc aatctgagtc
    36361 tgaccatagc taaccacata gtttccttgt cctaagagtt ggaaaacaaa gtcaaaagtg
    36421 acactatatt cagccacata gtttttataa gcagcacttc cttgtccaat ctcatgatta
    36481 tgctgaatca aatcgtctgc cacataatca ctccactgct ctagctcccc attttggaaa
    36541 atttctgtca agaaacggcg aaccagcttt ttattttctg ctttcttatc caaatccttg
    36601 atttcaaaat ctccaaaaat ttgatctagt tggtcatttt caggtgttcg atagtagtca
    36661 atgacatccc aatgctcaac aatacgacca ttctcatccg cacgaaaagt atccgtcgtc
    36721 acccattgag cttctccacc attcagatat tgatgaacat gaacaaagac cagattgcca
    36781 tcctcaatgg tgcggacaat cttaatctga cgctctggat gacgctcaaa gaaatctgca
    36841 aagaaggctg caaatccttc tttcccgtca ggaacacctg tcgaatgttg gatataggta
    36901 tcccctacag actgggcttg agcctcagca actcgtccgt cttgaatggc atggatgtat
    36961 aggttgtgag catttttcac ttgttgtgac atattctaaa cctcatttcc cttctctttc
    37021 aaattcgcca aaattctttc ttgaaaacct tcaaattggt gaatttcttc ctctgaaaat
    37081 cctttgtaaa agatagtatc caatttctga ctgacacgat gccccacttc tttctgggac
    37141 ttgcctaact ccgttaaaac taaatacttc ttacgcttgt cttttccaca cggactaaca
    37201 attacaagct tttgttcctc tagctttttt atcatagtcg tcagcgtatt attcgcaagc
    37261 ccagtcgcaa gcgcgatatc tgtcgcagtt gcgcagccag tttcactatt ccataaaacc
    37321 gctaaaatct tgccctgttc acccctataa agagcctcag gatcttgact cagtaacttt
    37381 tgaaaaatcc gcccattcaa caaacgaata tgatgggcta gcaaatgacc atctttcata
    37441 acacctccaa tttatttcga tatcgaaatg aataaaacaa ttgtaacact catcgttcta
    37501 actgtcaact atttcgattt agaaataatt tttgataatt atccacacca ccatactccg
    37561 gctcaactaa cttttaacga gagtttctaa actccttcgt cctccagtct acaaaagcct
    37621 tccattcgta ctatcctata ttttatgagg ggacacattt ttcctatcag accatttatt
    37681 ttaaagatag aagtaaatca taattgcttc catctgttct tttatagtat attgaagtta
    37741 gactagagca ctgtatcttc taaaacattg atagaaagcg atttgaattt cccaatcaat
    37801 ttgttcgtat ttatagcatt tcgaaactgg aataggacac catgactgct aaaagatttc
    37861 tataaattca tttgattttc ctaatcaatt tgttcatatc ttatttcatt ccgctataat
    37921 ttcaccttac cctatctttt tcgtagcacc cttcaaacag cctatcccct accgtttgac
    37981 gattcctcac ttcgctccac ttccattaca gaagtttctt cactactatg ggctcggctg
    38041 acttctcatg attccttgtt actactattt gaacgctcac gagatagatc ttacaaaaaa
    38101 tgctttgatc cacaatggaa tcaaagcatt ttaaagagtt cctcatacat aagcgcagaa
    38161 gtcgcagttc ctctgtactt ggcttcttct cttttgataa agcgagccaa gttgagcaac
    38221 tcaggtgctg gatgtttggg atttaggagc aattcacgat tgaccaggcc tgagagacga
    38281 actgcctgca attgttcatt tgtagtaggc agttttttag cagtctctag gagagcagca
    38341 actaaatctt cactcaaatc atgtcgagca tgattgtaaa gatcttttat aaggctttct
    38401 aggtttggtt ctgccatccc taccacctcc cttatggttt aataatgttt aatcaaatca
    38461 accgttgaac gatccaattt cttcaccaag gcttgtaaga aagcttgcgc ttctaggaag
    38521 tcatccattg catagagggt ttggtgagaa tggatataac gagcgcagac accgatagtt
    38581 gttgatggga caccaccatt tttcagatga gctgcacctg catctgttcc gcctttacca
    38641 cagtagtatt ggtacttgat accagcttct tcagccgttg tcaaaagaaa atccttcatc
    38701 cctgggagaa gcaagtgacc tggatcatag aaacgaatca aggttccatc tccaattttg
    38761 ccttgaccac cgtagacatc acctgctggt gagcaatcaa ctgcgaggaa gacttctggg
    38821 tcaaacttgg ttgtagaggt atgagcgcca cgcagaccaa cttcttcttg gacgttagaa
    38881 cccagataga gttcattgcc gagtttttga cctgataaag cttcagctag ctcgcttacc
    38941 atgaggacac cgtagcggtt atcccaagct tttgagatga tatttttttc attggctgtc
    39001 aaaattgcag aactatctgg tacgatggta tcaccaggac ggatgccaaa actttctgcc
    39061 tcagccttgt ccgcaaaacc accatcaaaa acgatatcgg caatggctgg catggttggt
    39121 cccccctttc cacgagtcaa atgcggagga acagaacctg aaatcacagg aatttcatga
    39181 ccatcacgag tcaagagttt gaaacgttgg ctgctaacca ccatggggtt ccagccaccg
    39241 atttctacga cacggaaggt accatctggc ttgatttcgc tgaccataaa accaacttcg
    39301 tccatatgag aagcgaccaa gacgcgcggt gcatccacag cttctgaatg tttgatacca
    39361 aaaataccac ccaagccatc tgtcaccact tcatccacat acggtgtcaa cttttcacga
    39421 agataagcac ggacaggcgc ttcatgacct gagactgcag caagttctgt tacttcttta
    39481 atttttgaaa ataatgttgt catttcagtt ccttctttct ttcatccatt ttaccacttt
    39541 ttataggaga aggatagtgg gaaggtggat ttctaagtta gtatcttagt cctgctctat
    39601 cttagaaaag gatagtattc tcttgcatgt agtgcaaaat ctagtaaaca ttccaaaatt
    39661 aactcgaata tttatttcca aacaaaaaaa caatacacca tcaaagttgt ttagattttt
    39721 catgaaattt acagaaaata gttgacttcc ctttcttctt tctttaaata tatagttggt
    39781 tgagtttgga atagtacgct gtagctgcta aaacatttct agaaattaat ttgactttcc
    39841 taatagagtt gttcatatct tatttcaatt tactatagta caaaactaga aaaggaaaaa
    39901 atcatgacca aaacaattct tgttacaggt gggactagct acattagctc ccataccgtt
    39961 aaagctcttt taaatgctgg ctatcaggtg catgtcctcg ataatctctc cacaggaaat
    40021 cgagcggctg tggatagtcg tgctagcttt aaagaactgg atgtttatga tgctagcgcc
    40081 ttaaaggctt acttagaaga aaatcagatt gatgctgtcc tccattgtgc aggtgaaatt
    40141 gttgtgagcg aaagtattga aaatccaagt aaatacttca ctgccaacgt tgctggtatg
    40201 aaccaagttc tcaaagtctt atctgaagtt ggcattcaaa aaatcatgtt ctcttcgact
    40261 gcttctctct atggaaataa ctgtattgac aagccggtga ctgaagatac cctgctcgac
    40321 cctgtcaacc cttatgcaga gacaaaactg atgggcgaac gaatgattta ctggatggcc
    40381 aatcgctacg actggaaata tgttattttc cgttacttta atgctgctgg ggctgaaatg
    40441 gatgcttcaa acggtctgcg tgtgaaaaat ccaactcaca tcattccaaa tatcaacaag
    40501 accgcattgg gacaaaatga tagcttaaaa atatttggag atgactacga tacacgtgac
    40561 ggttcatgta ttcgagatta catttatgtc ttggaccttg cataggctca tgttaaagga
    40621 atgaactacc tatttcaaga agacagttct tctcaaatct ttaacttagg aactaaaaaa
    40681 ggctatacta tcaaagaaat ctttaaaact gctgaagaat tactaaatta aaaaatccca
    40741 cacgagattg ttgctcgacg tgctagtgac ccagccagtg tcctagcaga tgcttcaaaa
    40801 gctaaacaat atcttgattg gacggctagc tactccctcg aagatattat tttatcagat
    40861 taaggtaaaa acattttaga ataggataac aaaggagaaa gtcttgttgc tctctccttg
    40921 ttgtatttat taaattatca gaaattttat tgacagatta gaaaaataat gttacattta
    40981 tatccgcaga tatctttcga taccaaatct acatgaaagg acggggtatg aaactttctc
    41041 attatttaat tggcttactt ctactcctag tctttctctc tattagcatt gggaccagtg
    41101 atttttcatg gggaaagcta tttgatttcg accagcagac ctggctcctc tttcaagagt
    41161 cccgtctccc aagaactatc agtattctcc tgactgcctc tagtatgagt atggcaggcc
    41221 ttctcatgca gactattacc caaaatcagt ttgctgcacc gagtacagtt ggaacgactg
    41281 aagccgccaa actgggaatg gtgctgagcc tttttgtctt tccatcggct agtctgaccc
    41341 aaaagatgct cttcgctttt gtttcatcca tcgtattcac cctcttcttc ctagccttta
    41401 tgaccatttt tactgtaaag gaaaggtgga tgttgcctct gattgggatc atctatagcg
    41461 ggattatcgg ctcagtcaca gaagttatcg cctatcgttt caatctggtt cagagtatga
    41521 ctgcctggac ccagggctcc ttctccatga ttcagaccca tcagtatgag tggctcttct
    41581 taggcctcat catcctgata accgtttgga aattatccca aaccttcacc atcatgaatc
    41641 tggggaaaga aaccagcgag agtttgggga tttcctactc cctacttgaa aaactggccc
    41701 tctttctggt ggcgctaacg acaagcgtca ccatgattac cgtgggtggc ttaccatttc
    41761 tcggagttat cgttcccaat cttgttcgca agcgctatgg agataatcta agtcaaacca
    41821 aactcatggt cgcactggtt ggtgccaatc tagttctggc ttgcgatatc ctatcccgag
    41881 ttctgattag gccctatgag ttgtctgtca gtctcttgct aggaatcatc ggtagtctcg
    41941 tctttatcct acttctctgg agagggggac gaaaagatgc agactaaaag caaacatacc
    42001 aagctcttct ggattctcat tattcttgcc atcggagctt gtcttctcta cttttggccc
    42061 atcactcact tgtcagcctt tgcttggaag ttgcgttccc aaaagatcat cgtttatctc
    42121 ttggtagcca tcgcgactgg gatttcgacc attagttttc aaaccctgac ggaaaatcgc
    42181 ttcctgacgc ctagtatttt gggaattgaa tccttctacg tcctactaca aaccctacta
    42241 ctggtttttg aaagcaagtt tcttcaactt ggcaaatccc ctatcttaga attcctagtc
    42301 ttacttcttg tccagtcctt cttctttctc gccttacaag gttacttgaa gacactgatg
    42361 aagcaagacc tggtcttcat cctgctgatc tgtctagcgc tcagaagtct ctttcgaaat
    42421 atcagcacct tccttcaagt cctaatggat ccaaacgaat acgataaact gcaaaatagt
    42481 ctttttgcct cctttcaaca tcttaacact tccatcctag ccatcggttc tctgatcatc
    42541 ctcgctttga caatcttttt ctttcgaaaa gcagtcgttc tagatgtctt gcacctgcaa
    42601 agagaaacgg ctcagatatt gggactcgat gttgaaaaag aacagaaaga gctcctctgg
    42661 ggaatcgtgc ttttgacctc aacggccact gccttggtag gacctatggc cttcttcggc
    42721 tttatgctgg ccaacctcac ctacctgatt gtcaaagact atcagcacaa gttactcttt
    42781 atagtggcca ttctggttgg atttattagc ttaaccttgg ggcaagcctt gattgaacga
    42841 gtctttgcac tggaaattcg tatcagtatg atcattgaga gtgtgggtgg cttcttattc
    42901 tttatcttac tatataggag gtctcgtcag tgaaactgga aaacattgac aaatccattc
    42961 aaaaacagga tattttgcaa ggcatttcgc ttgaagtcag tcctcaaaaa ctgacagcct
    43021 ttattggtcc aaatggtgct ggaaaatcga ctctcctctc catcatgagc agactaacca
    43081 agaaagatca gggagttctc agtatcaaag gacgtgaaat cgagagctgg aattcgcaag
    43141 aactggctca agaactaacc atcctaaaac agaaaatcaa ttaccaagcc aaattgactg
    43201 ttgaagaact ggtcagtttt ggacgttttc cctacagccg aggtcgactt agatcagaag
    43261 actgggaaaa aatccgagaa actctgaact atttggaact gaccaactta aaagaccgct
    43321 acatcaatag cctgtcaggg gggcaactcc agcgcgtctt tatcgctatg gtactggccc
    43381 aggatacgga ctttatcttg ctggacgaac cactcaacaa tctcgatatc aagcaaagcg
    43441 tcagcatgat gcagattctt cgacgactgg tggaggaact cggcaagacc attatcatcg
    43501 tcctccacga tatcaacatg gccagtcagt atgcagatga aattgtcgcc ttcaaggacg
    43561 gccaggtctt tagcaaggga agaaccgatc aaatcatgca ggctgacctg ctcagtcaac
    43621 tttatgagat tcccatcacg ctagctgata tcaataacaa aaagatctgt atctatagct
    43681 agtaacataa aagctcaagt tagagaacct tcagtctctt agtcaataag attaagagac
    43741 tccctaaatc gttatcacat tttaaaaagg agaaattatg aaaacatccc ttaaacttta
    43801 tttcactgcc ctagtggcca gcttcttgct cctacttggt gcatgtagta caaactcaag
    43861 cactagtcag acagagacca gtagctctgc tccaacagag gtaaccatta aaagttcact
    43921 ggacgaggtc aaactttcca aagttcctga aaagattgtg acctttgacc tcggcgctgc
    43981 ggatactatt cgcgctttag gatttgaaaa aaatatcgtc ggaatgccta caaaaactgt
    44041 tccgacttat ctaaaagacc tagtgggaac tgtcaaaaat gttggttcta tgaaagaacc
    44101 tgatttagaa gctatcgccg cccttgagcc tgatttgatt atcgcttcac cacgtacaca
    44161 aaaattcgta gacaaattca aagaaatcgc cccaaccgtt ctcttccaag caagcaagga
    44221 cgactactgg acttctacca aggctaatat cgaatcctta gcaagtgcct tcggcgaaac
    44281 tggtacacag aaagccaagg aagaattggc caagctagac aagagcatcc aagaagtcgc
    44341 tactaaaaat gaaagctctg acaaaaaagc ccttgcgatc ctccttaatg aaggaaaaat
    44401 ggcagccttt ggtgccaaat ctcgtttctc tttcttgtac caaaccttga aattcaaacc
    44461 aactgataca aaatttgaag actcacgcca cggacaagaa gtcagctttg aaagtgtcaa
    44521 agaaatcaac cctgacatcc tctttgtcat caaccgtacc cttgccatcg gtggggacaa
    44581 ctctagcaac gacggtgtcc tagaaaatgc ccttatcgct gaaacacctg ctgctaaaaa
    44641 tggtaagatt atccaactaa caccagacct ctggtatcta agcggaggcg gacttgaatc
    44701 aacaaaactc atgattgaag acatacaaaa a
//
LOCUS       DBMVGT010000011        40221 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.011, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000011 DBMVGT010000000
VERSION     DBMVGT010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 40221)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 40221)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..40221
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.011"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            371..598
                     /locus_tag="AC0DU4_000624"
     CDS             371..598
                     /locus_tag="AC0DU4_000624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236625.1"
                     /translation="MIFKAFKTKKQRKRQVELLLTIFFDSFLIDLFLHLFGIVPFKLD
                     KILIVSLIIFPIISTSIYAYEKLFEKVFDKD"
     gene            886..3783
                     /gene="nanA"
                     /locus_tag="AC0DU4_000625"
     CDS             886..3783
                     /gene="nanA"
                     /locus_tag="AC0DU4_000625"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored neuraminidase NanA"
                     /protein_id="HIN4236626.1"
                     /translation="MNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASE
                     QPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLEN
                     VETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSS
                     ATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTPE
                     LPKGRVRLYVNGVLSRTSLKSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTV
                     YNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIP
                     ALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASD
                     PSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILY
                     REGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGDQLLGNIYFTTN
                     KTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPH
                     KGRILIPVYTTNNVSHLDGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMN
                     NRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQ
                     MSAIHTMHNGKEYIILSNAGGPKRENGMVHLARVEENGELTWIKHNPIQKGEFAYNSL
                     QELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGEMG
                     KGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKG
                     SIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLV
                     TLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ"
     gene            4798..5250
                     /locus_tag="AC0DU4_000626"
                     /pseudo
     CDS             4798..5250
                     /locus_tag="AC0DU4_000626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587452.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
     gene            5269..6606
                     /locus_tag="AC0DU4_000627"
     CDS             5269..6606
                     /locus_tag="AC0DU4_000627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4236627.1"
                     /translation="MKKMRKFLCLAGIALAAVALVACSGKKEATTSTEPPTELSGEIT
                     MWHSFTQGPRLESIQKSADAFMQKHPKTKIKIETFSWNDFYTKWTTGLANGNVPDIST
                     ALPNQVMEMVNSDALVPLNDSIKRIGQDKFNETALNEAKIGDDYYSVPLYSHAQVMWV
                     RTDLLKEHNIEVPKTWDQLYEASKKLKEAGVYGLSVPFGTNDLMATRFLNFYVRSGGG
                     SLLTKDLKADLTSQLAQDGIKYWVKLYKEISPQDSLNFNVLQQATLFYQGKTAFDFNS
                     GFHIGGINANSPQLIDSIDAYPIPKIKESDKDQGIETSNIPMVVWKNSKHPEVAKAFL
                     EALYNEEDYVKFLDSTPVGMLPTIKGISDSAAYKENETRKKFKHAEEVITEAVKKGTA
                     IGYENGPSVQAGMLTNQHIIEQMFQDIITNGTDPMKAAKEAEKQLNDLFEAVQ"
     gene            6685..7569
                     /locus_tag="AC0DU4_000628"
     CDS             6685..7569
                     /locus_tag="AC0DU4_000628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4236628.1"
                     /translation="MVKERNLTRWIFVLPAMIIVGLLFVYPFFSSIFYSFTNKHLIMP
                     NYKFVGLANYKAVLSDPNFFNAFFNSIKWTVFSLVGQVLVGFVLALALHRVRHFKKLY
                     RTLLIVPWAFPTIVIAFSWQWILNGVYGYLPNLIVKLGLMEHTPAFLTDSTWAFLCLV
                     FINIWFGAPMIMVNVLSALQTVPEEQFEAAKIDGASSWQVFKFIVFPHIKVVVGLLVV
                     LRTVWIFNNFDIIYLITGGGPANATTTLPIFAYNLGWGTKLLGRASAVTVLLFIFLVA
                     ICFIYFAIISKWEKEGRK"
     gene            7569..8402
                     /locus_tag="AC0DU4_000629"
     CDS             7569..8402
                     /locus_tag="AC0DU4_000629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4236629.1"
                     /translation="MKKKSSIYLDILSHVLLVGATIVAIFPLVWIIISSVKGKGELTQ
                     YPTRFWPEQFTLDYFTHVINDLHFIDNIRNSLIIALATTLITIIISAMAAYGIVRFFP
                     KLGAIMSRLLVITYIFPPILLAIPYSIAIAKVGLTNSLFGLMMVYLSFSVPYAVWLLV
                     GFFQTVPIGIEEAARIDGANKFVTFYKVVLPIVAPGIVATAIYTFINAWNEFLYALIL
                     INNTGKMTVAVALRSLNGSEILDWGDMMAASVIVVLPSIIFFSIIQNKIASGLSEGSV
                     K"
     gene            8421..10514
                     /gene="nanB"
                     /locus_tag="AC0DU4_000630"
     CDS             8421..10514
                     /gene="nanB"
                     /locus_tag="AC0DU4_000630"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="neuraminidase NanB"
                     /protein_id="HIN4236630.1"
                     /translation="MNKRGLYSKLGISVVGISLLMGVPTLIHANELNYGQLSISPIFQ
                     GGSYQLNNKSIDISSLLLDKLSGESQTVVMKFKADEPNSLQALFGLSNSKAGFKNNYF
                     SIFMRDSGEIGVEIRDAQKGINYLFSRPASLWGKHKGQAVENTLVFVSDSKDKTYTMY
                     VNGIEVFSETVDTFLPISNINGIDKATLGAVNREGKEHYLAKGSIDEISLFNKAISDQ
                     EVSNIPLSNPFQLIFQSGDSTQANYFRIPTLYTLSSGRVLSSIDARYGGTHDSKSKIN
                     IATSYSDDNGKTWSEPIFAMKFNDYEEQLVYWPRDNKLKNSQISGSASFIDSSIVEDK
                     KSGKTILLADVMPAGIGNNNANKADSGFKEINGHYYLKLKKNGDNDFRYTVRENGVVY
                     DETTNKPTNYTINDKYEVLEGGKSLTVEQYSVDFDSGSLREKHNGKQVPMNVFYKDSL
                     FKVTPTNYIAMTTSQNRGESWEQFKLLPPFLGEKHNGTYLCPGQGLALKSSNRLIFAT
                     YTSGELTYLISDDSGQTWKKSSASIPFKNATAEAQMVELRDGVIRTFFRTTTGKIAYM
                     TSRDSGETWSKVSYIDGIQQTSYGTQVSAIKYSQLIDGKEAVILSTPNSRSGRKGGQL
                     VVGLVNKEDDSIDWKYHYDIDLPSYGYAYSAITELPNHHIGVLFEKYDSWSRNELHLS
                     NVVQYIDLEINDLTK"
     gene            10527..11630
                     /locus_tag="AC0DU4_000631"
     CDS             10527..11630
                     /locus_tag="AC0DU4_000631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="HIN4236631.1"
                     /translation="MVKYGVVGAGYFGAELARYMQKNDGAEITLLYDPDNAEAIAEEL
                     GAKVASSLDELVSSDEVDCVIVATPNNLHKEPVIKAAQHGKNVFCEKPIALSYQDCRE
                     MVDACKENNVTFMAGHIMNFFNGVHHAKELINQGVIGDVLYCHTARNGWEEQQPSVSW
                     KKIREKSGGHLYHHIHELDCVQFLMGGMPETVTMTGGNVAHEGEHFGDEDDMIFVNME
                     FSNKRFALLEWGSAYRWGEHYVLIQGSKGAIRLDLFNCKGTLKLDGQESYFLIHESQE
                     EDDDRTRIYHSTEMDGAIAYGKPGKRTPLWLSSVIDKEMRYLHEIMEGAPVSEEFAKL
                     LTGEAALEAIATADACTQSMFEDRKVKLSEIVK"
     gene            11804..12502
                     /locus_tag="AC0DU4_000632"
     CDS             11804..12502
                     /locus_tag="AC0DU4_000632"
                     /EC_number="5.1.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047465 - N-acylglucosamine-6-phosphate
                     2-epimerase activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006051 - N-acetylmannosamine metabolic
                     process [Evidence IEA];
                     GO_process: GO:0019262 - N-acetylneuraminate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HIN4236632.1"
                     /translation="MPQISKEALIEQIKDGIIVSCQALPHEPLYTEAGGVIPLLVKAA
                     EQGGAVGIRANSVRDIKEIKEVTKLPIIGIIKRDYPPQEPFITATMKEVDELAELDIE
                     VIALDCTKRERYDGLEIQEFIRQVKEKYPNQLLMADTSIFEEGLAAVEAGIDFVGTTL
                     SGYTSYSPKVDGPDFELIKKLCDAGVDVIAEGKIHTPEQAKQILEYGVRGIVVGGAIT
                     RPKEITERFVASLK"
     gene            12521..14038
                     /locus_tag="AC0DU4_000633"
     CDS             12521..14038
                     /locus_tag="AC0DU4_000633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HIN4236633.1"
                     /translation="MFKVLQKVGKAFMLPIAILPAAGLLLGIGGALSNPTTIATYPIL
                     DNSIFQSIFQVMSSAGEVVFSNLSLLLCVGLCIGLAKRDKGTAALAGVTGYLVMTATI
                     KALVKLFMAEGSAIDTGVIGALVVGIVAVYLHNRYNNIQLPSALGFFGGSRFVPIVTS
                     FSSILIGFVFFVIWPPFQQLLVSTGGYISQAGPIGTFLYGFLMRLSGAVGLHHIIYPM
                     FWYTELGGVETVAGQTVVGAQKIFFAQLADPAHSGLFTEGTRFFAGRFSTMMFGLPAA
                     CLAMYHSVPKNRRKKYAGLFFGVALTSFITGITEPIEFMFLFVSPVLYVVHAFLDGVS
                     FFIADVLNISIGNTFSGGVIDFTLFGILQGNAKTNWVLQIPIGLIWSVLYYIIFRWFI
                     TQFNVLTPGRGEEVDSKEISESADSTSNTADYLKQDSLQIIRALGGSNNIEDVDACVT
                     RLRVAVKEVNQVDKALLKQIGAVDVLEVKGGIQAIYGAKAILYKNSINEILGVDD"
     gene            14163..15491
                     /locus_tag="AC0DU4_000634"
     CDS             14163..15491
                     /locus_tag="AC0DU4_000634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4236634.1"
                     /translation="MKFRKLACTVLAGAVVLGLAACGNSGGSKDAAKSGGDGAKTEIT
                     WWAFPVFTQEKTGDGVGTYEKSIIEAFEKANPDIKVKLETIDFKSGPEKITTAIEAGT
                     APDVLFDAPGRIIQYGKNGKLAELNDLFTDEFVKDVNNENIVQASKAGDKAYMYPISS
                     APFYMAMNKKMLEDAGVANLVKEGWTTDDFEKVLKALKDKGYTPGSLFSSGQGGDQGT
                     RAFISNLYSGSVTDEKVSKYTTDDPKFVKGLEKATSWIKDNLINNGSQFDGGADIQNF
                     ANGQTSYTILWAPAQNGIQAKLLEASKVEVVEVPFPSDEGKPALEYLVNGFAVFNNKD
                     DKKVAASKKFIQFIADDKEWGPKDVVRTGAFPVRTSFGKLYEDKRMETISGWTQYYSP
                     YYNTIDGFAEMRTLWFPMLQSVSNGDEKPADALKAFTEKANETIKKAMKQ"
     gene            15743..16609
                     /locus_tag="AC0DU4_000635"
     CDS             15743..16609
                     /locus_tag="AC0DU4_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4236635.1"
                     /translation="MRETVISYAFLAPVLFFFVIFVLAPMVMGFITSFFNYSMTKFEF
                     VGLDNYIRMFKDPVFTKSLINTVILVIGSVPVVVLFSLFVASQTYHQNVIARSFYRFV
                     FFLPVVTGSVAVTVVWKWIYDPLSGILNFVLKSSHIISQNISWLGDKNWALMAIMIIL
                     LTTSVGQPIILYIAAMGNIDNSLVEAARVDGATEFQVFWKIKWPSLLPTTLYIAIITT
                     INSFQCFALIQLLTSGGPNYSTSTLMYYLYEKAFQLTEYGYANTIGVFLAVMIAIVSF
                     VQFKVLGNDVEY"
     gene            16625..17464
                     /locus_tag="AC0DU4_000636"
     CDS             16625..17464
                     /locus_tag="AC0DU4_000636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4236636.1"
                     /translation="MQSTEKKPLTAFTVISTIILLLLTVLFIFPFYWILTGAFKSQPD
                     TIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAK
                     KRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWPFGVFLM
                     KQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLV
                     MLTSRNNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGITMGA
                     VKG"
     gene            17737..18189
                     /locus_tag="AC0DU4_000637"
     CDS             17737..18189
                     /locus_tag="AC0DU4_000637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HIN4236637.1"
                     /translation="MIFDDLKNITFYKGIHPNLDKAIDYLYQHRKDSFELGKYEIDGD
                     KVFLVVQENVLNQVENNQFEHHKNYADLHLLIEGHEYSSYGSRIKDEAVAFDEASDIG
                     FVHCYEHYPLLLGYHNFAIFFPGEPHQPNGYAGMEEKVRKYLFKILID"
     gene            18286..18630
                     /locus_tag="AC0DU4_000638"
     CDS             18286..18630
                     /locus_tag="AC0DU4_000638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236638.1"
                     /translation="MVSSKYAARASFLDGQGITVDEMAWIIRGIVNALIGRYIKLGAY
                     AAKYGISMARSILSRAAATAAARVGLSTKISGWILRVAVNVADVYGNFAYNIAAAWDA
                     HDKIPNNGRINF"
     gene            18640..18831
                     /locus_tag="AC0DU4_000639"
     CDS             18640..18831
                     /locus_tag="AC0DU4_000639"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236639.1"
                     /translation="MKALCIFLLNMLAWTVLAMIIRGGLDGFNEHTWSTILIASLFGV
                     YDYKPIDKNRKKSKRKKKK"
     gene            18914..19558
                     /locus_tag="AC0DU4_000640"
     CDS             18914..19558
                     /locus_tag="AC0DU4_000640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000057467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HIN4236640.1"
                     /translation="MAQKGVSLIKAAFDTDNFLMRFSEKVLDIVTANLLFVVSCLPIV
                     TIGVAKISLYETMFEVKKSRRVPVFKIYLRSFKQNLKLGLQLGLMELGIVFLTLSDLY
                     LFWGQTALPFQLLKAICLGILIFLTIVMLASYPIAARYDLSWKEILQKGLMLASFNFP
                     WFFLMLAILVLIVMVLYLSAFSLLLGGSVFLLFGFGLLVFIQTGLMEKIFAKYQ"
     gene            19727..20644
                     /locus_tag="AC0DU4_000641"
     CDS             19727..20644
                     /locus_tag="AC0DU4_000641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HIN4236641.1"
                     /translation="MSDLKKYEGVIPAFYACYDDQGEVSPERTRALVQYFIDKGVQGL
                     YVNGSSGECIYQSVEDRKLILEEVMAVAKGKLTIIAHVACNNTKDSMELARHAESLGV
                     DAIATIPPIYFRLPEYSVAKYWNDISSAAPNTDYVIYNIPQLAGVALTPSLYTEMLKN
                     PRVIGVKNSSMPVQDIQTFVSLGGEDHIVFNGPDEQFLGGRLMGAKAGIGGTYGAMPE
                     LFLKLNQLIADKDLETARELQYAINAIIGKLTSAHGNMYGVIKEVLKINEGLNIGSVR
                     SPLTPVTEEDRPVVEAAAALIRETKERFL"
     gene            20662..21546
                     /locus_tag="AC0DU4_000642"
     CDS             20662..21546
                     /locus_tag="AC0DU4_000642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HIN4236642.1"
                     /translation="MTYYVAIDIGGTNIKYGLVDQEGQLLESHEMPTEAHKGGPHILQ
                     KTKDIVASYLEKGLVAGVAISSAGMVDPDKGEIFYAGPQIPNYAGTQFKKEIEESFTI
                     PCEIENDVNCAGLAEAVSGSGKGASMTLCLTIGTGIGGCLIMDRKVFHGFSNSACEVG
                     YMHMQDGAFQDLASTTALVKYVAEAHGEDVDQWNGRRIFKEATEGNKICMEGIDRMVD
                     YLGKGLANICYVANPEVVILGGGIMGQEAILKPKIRTALKEALVPSLAEKTRLEFAHH
                     QNTAGMLGAYYHFKTKQS"
     gene            complement(21562..22413)
                     /locus_tag="AC0DU4_000643"
     CDS             complement(21562..22413)
                     /locus_tag="AC0DU4_000643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HIN4236643.1"
                     /translation="MDKPDIATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVT
                     QKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQANQVSKHSPLTKRVLRSYSNMR
                     EQTQDLIDEIQLERIAQLIEDAERIYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQD
                     GFAWTTSIMDENCLVLGFSLSGSTPSILDSLLDAKEMGAKTVLFTSVPNKNSQTYTET
                     VLVATHSQPSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRR
                     QKRVRKS"
     gene            22613..24670
                     /gene="pbp2b"
                     /locus_tag="AC0DU4_000644"
     CDS             22613..24670
                     /gene="pbp2b"
                     /locus_tag="AC0DU4_000644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2B"
                     /protein_id="HIN4236644.1"
                     /translation="MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNK
                     DFYEKKLASASQTKITSSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETA
                     KKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNN
                     AVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMP
                     GISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQ
                     YEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFN
                     SELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSV
                     VKAATISSGWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSN
                     TYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRSTFGEYGLGTATGIDLPDESTGFV
                     PKEYSFANYITNAFGQFDNYTPMQLAQYVATIANDGVRVAPRIVEGIYGNNDKGGLGD
                     LIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSELTTGRAFSNGALVSISGKTGTA
                     ESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYH
                     PMN"
     gene            24681..25277
                     /gene="recR"
                     /locus_tag="AC0DU4_000645"
     CDS             24681..25277
                     /gene="recR"
                     /locus_tag="AC0DU4_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombination mediator RecR"
                     /protein_id="HIN4236645.1"
                     /translation="MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSADDVNEFA
                     KNLLSAKRELTYCSICGRLTDDDPCSICTDPTRDQTTILVLEDSRDVAAMENIQEYHG
                     LYHVLHGLISPMNGISPDDINLKSLMTRLMDSEVSEVIVATNATADGEATSMYLSRLL
                     KPAGIKVTRLARGLAVGADIEYADEVTLLRAIENRTEL"
     gene            25453..26496
                     /locus_tag="AC0DU4_000646"
     CDS             25453..26496
                     /locus_tag="AC0DU4_000646"
                     /EC_number="6.3.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HIN4236646.1"
                     /translation="MKQTIILLYGGRSAEREVSVLSAESVMRAVDYDRFTVKTFFISQ
                     SGDFIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSV
                     QGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEV
                     EEKLAYPVFTKPSNMGSSVGISKSENQEELRQALELAFRYDSRVLVEQGVNAREIEVG
                     LLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKITMDIPAKISDDVVAVMRQNAETAFR
                     AIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWDNMGISYPELIERLVDL
                     AKESFDKREAHLI"
     gene            26580..27953
                     /locus_tag="AC0DU4_000647"
     CDS             26580..27953
                     /locus_tag="AC0DU4_000647"
                     /EC_number="6.3.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0047480 -
                     UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase
                     activity [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HIN4236647.1"
                     /translation="MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVP
                     LKGARDGHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDV
                     FAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMG
                     QDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAP
                     ADPIVEDYLPTDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQALDLPVTGKYNAT
                     NAMIASYVALQEGVSEEQIRLAFQGLELTRNRTEWKKAANGADILSDVYNANPTAMKL
                     ILETFSAIPANEGGKKIAVLADMKELGDQSIQLHNQMILSLSPDVLDTVIFYGEDIAE
                     LAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLSANDQILLKGSNSMNLAMLVE
                     SLENETK"
     gene            27940..28551
                     /locus_tag="AC0DU4_000648"
     CDS             27940..28551
                     /locus_tag="AC0DU4_000648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase N-terminal domain-containing
                     protein"
                     /protein_id="HIN4236648.1"
                     /translation="MKPSDFVKYLQRMIALTDTGLTFTKDPFDRERYEDLRSLLSEML
                     NQGSDLDAEEVAEVLKPTSAYATPLMDVRAWIVEDEKICLVRGQGEDSWALPGGFGEV
                     GYSPTENILKEIEEETGFKAKVERLLAVFDTNRFQLQSKQYAKFVFECKLLDGQFQEN
                     QEIADLQFFAIDQLPNLSEKRITKEQIELLWQVYQGQREQYLD"
     gene            28642..29346
                     /locus_tag="AC0DU4_000649"
     CDS             28642..29346
                     /locus_tag="AC0DU4_000649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001055242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02206 family membrane protein"
                     /protein_id="HIN4236649.1"
                     /translation="MNLWDIFFTTQATEPPKFDLFWYVSLFTLLALTFYTAHRYREKK
                     VYQRFFQILQTVQLILLYGWYWVNHMPLSESLPFYHCRMAMFVVLLLPGQSKYKQYFA
                     LLGTFGTLAAFVYPVPDAYPFPHITILSFIFGHLALLGNSLVYLLRQYNARLLDVKGI
                     FLMTFALNALIFVVNLVTGGDYGFLTKPPLVGDHGLVANYLLVSIVLVATISLTKKIL
                     EFFLAQEAEKMIAKEA"
     gene            29565..30938
                     /gene="ftsA"
                     /locus_tag="AC0DU4_000650"
     CDS             29565..30938
                     /gene="ftsA"
                     /locus_tag="AC0DU4_000650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000090410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0043093 - FtsZ-dependent cytokinesis
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsA"
                     /protein_id="HIN4236650.1"
                     /translation="MAREGFFTGLDIGTSSVKVLVAEQRTGELNVIGVSNAKSKGVKD
                     GIIVDIDAAATAIKSAISQAEEKAGISIKSVNVGLPGNLLQVEPTQGMIPVTSDTKEI
                     TDQDVENVVKSALTKSMTPDREVITFIPEEFIVDGFQGIRDPRGMMGVRLEMRGLLYT
                     GPRTILHNLRKTVERAGVQVENVIISPLAMVQSVLNEGEREFGATVIDMGAGQTTVAT
                     IRNQELQFTHILQEGGDYVTKDISKVLKTSRKLAEGLKLNYGEAYPPLASKETFQVEV
                     IGEVEAVEVTEAYLSEIISARIKHILEQIKQELDRRRLLDLPGGIVLIGGNAILPGMV
                     ELAQEVFGVRVKLYVPNQVGIRNPAFAHVISLSEFAGQLTEVNLLAQGAIKGENDLSH
                     QPISFGGMLQKTAQFVQSTPVQPAPAPEVEPVAPTEPMADFQQASQNKPKLADRFRGL
                     IGSMFDE"
     gene            30955..32214
                     /gene="ftsZ"
                     /locus_tag="AC0DU4_000651"
     CDS             30955..32214
                     /gene="ftsZ"
                     /locus_tag="AC0DU4_000651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000144288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HIN4236651.1"
                     /translation="MTFSFDTAAAQGAVIKVIGVGGGGGNAINRMVDEGVTGVEFIAA
                     NTDVQALSSTKAETVIQLGPKLTRGLGAGGQPEVGRKAAEESEETLTEAISGADMVFI
                     TAGMGGGSGTGAAPVIARIAKDLGALTVGVVTRPFGFEGSKRGQFAVEGINQLREHVD
                     TLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITNPGLINLDFADVKTV
                     MANKGNALMGIGIGSGEERVVEAARKAIYSPLLETTIDGAEDVIVNVTGGLDLTLIEA
                     EEASQIVNQAAGQGVNIWLGTSIDESMRDEIRVTVVATGVRQDRVEKVVAPQARSATN
                     YRETVKPAHSHGFDRHFDMAETAELPKQNPRRLEPTQASAFGDWDLRRESIVRTTDSV
                     VSPVERFEAPISQDEDELDTPPFFKNR"
     gene            32219..32890
                     /locus_tag="AC0DU4_000652"
     CDS             32219..32890
                     /locus_tag="AC0DU4_000652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HIN4236652.1"
                     /translation="MNVKENTELVFREVAEASLSAHRESGSVSVIAVTKYVDVPTAEA
                     LLPLGVHHIGENRVDKFLEKYEALKDRDVTWHLIGTLQRRKVKDVIQYVDYFHALDSV
                     KLAGEIQKRSDRVIKCFLQVNISKEESKHGFSREELLEILPELARLDKIEYVGLMTMA
                     PFEASSEQLKEIFKATQDLQREIQEKQIPNMPMTELSMGMSRDYKEAIQFGSTFVRIG
                     TSFFK"
     gene            32900..33439
                     /locus_tag="AC0DU4_000653"
     CDS             32900..33439
                     /locus_tag="AC0DU4_000653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0000917 - division septum assembly
                     [Evidence IEA];
                     GO_process: GO:0043093 - FtsZ-dependent cytokinesis
                     [Evidence IEA];
                     GO_process: GO:0090529 - cell septum assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HIN4236653.1"
                     /translation="MSLKDRFDRFIDYFTEDEDSSLPYEKRDEPVFTPVNSSQEPALP
                     MNQPSQSAGTKENNITRLHARQQELANQSQRATDKVIIDVRYPRKYEDATEIVDLLAG
                     NESILIDFQYMTEVQARRCLDYLDGACHVLAGNLKKVASTMYLLTPVNVIVNVEDIRL
                     PDEDQQGEFGFDMKRNRVR"
     gene            33439..33702
                     /locus_tag="AC0DU4_000654"
     CDS             33439..33702
                     /locus_tag="AC0DU4_000654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HIN4236654.1"
                     /translation="MIFLIRMIYNAVDIYSLILVAFAVMSWFPGAYESSLGRWIVALV
                     KPVLAPLQRLPLQIAGLDLSVWVAIVLVRFLGENLVRFLAMIG"
     gene            33759..34484
                     /locus_tag="AC0DU4_000655"
     CDS             33759..34484
                     /locus_tag="AC0DU4_000655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HIN4236655.1"
                     /translation="MEWIKKVEDSYAPFLTPFINPHQEKLLKILAKTYGLACSSSGEF
                     VSSEYVRVLLYPDYFQPEFSDFEISLQEIVYSNKFEHLTHAKILGTVINQLGIERKLF
                     GDILVDEERAQIMINQQFLLLFQDGLKKIGRIPVSLEERPFTEKIDKLEQYRELDLSV
                     SSFRLDVLLSNVLKLSRNQANQLIEKKLVQVNYHVVDKSDYTVQVGDLISVRKFGRLR
                     LLQDKGQTKKEKKKITVQLLLSK"
     gene            34493..35281
                     /gene="divIVA"
                     /locus_tag="AC0DU4_000656"
     CDS             34493..35281
                     /gene="divIVA"
                     /locus_tag="AC0DU4_000656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIVA"
                     /protein_id="HIN4236656.1"
                     /translation="MPITSLEIKDKTFGTRFRGFDPEEVDEFLDIVVRDYEDLVRANH
                     DKNLRIKSLEERLSYFDEIKDSLSQSVLIAQDTAERVKQAAHERSNNIIHQAEQDAQR
                     LLEEAKYKANEILRQATDNAKKVAVETEELKNKSRVFHQRLKSTIESQLAIVESSDWE
                     DILRPTATYLQTSDEAFKEVVSEVLGEPIPVPIEEEPIDMTRQFSQAEMEELQARIEV
                     ADKELSEFEAQIKQEVEAPTPVVSPQVEEEPLLIQLAQCMKNQK"
     gene            35629..38421
                     /gene="ileS"
                     /locus_tag="AC0DU4_000657"
     CDS             35629..38421
                     /gene="ileS"
                     /locus_tag="AC0DU4_000657"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004822 - isoleucine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HIN4236657.1"
                     /translation="MKLKDTLNLGKTEFPMRAGLPTKEPVWQKEWEDAKLYQRRQELN
                     QGKPHFTLHDGPPYANGNIHVGHAMNKISKDIIVRSKSMSGFYAPFIPGWDTHGLPIE
                     QVLSKQGVKRKEMDLVEYLKLCREYALSQVDKQREDFKRLGVSGDWENPYVTLTPDYE
                     AAQIRVFGEMANKGYIYRGAKPVYWSWSSESALAEAEIEYHDLVSTSLYYANKVKDGK
                     GVLDTDTYIVVWTTTPFTITASRGLTVGADIDYVLVQPAGEARKFVVAAELLTSLSEK
                     FGWADVQVLETYRGQELNHIVTEHPWDTAVEELVILGDHVTTDSGTGIVHTAPGFGED
                     DYNVGIANNLEVAVTVDERGIMMKNAGPEFEGQFYEKVVPTVIEKLGNLLLAQEEISH
                     SYPFDWRTKKPIIWRAVPQWFASVSKFRQEILDEIEKVKFHSEWGKVRLYNMIRDRGD
                     WVISRQRAWGVPLPIFYAEDGTAIMVAETIEHVAQLFEEHGSSIWWERDAKDLLPEGF
                     THPGSPNGEFKKETDIMDVWFDSGSSWNGVVVNRPELTYPADLYLEGSDQYRGWFNSS
                     LITSVANHGVAPYKQILSQGFALDGKGEKMSKSLGNTIAPSDVEKQFGAEILRLWVTS
                     VDSSNDVRISMDILSQVSETYRKIRNTLRFLIANTSDFNPAQDTVAYDELRSVDKYMT
                     IRFNQLVKIIRDAYADFEFLTIYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQ
                     MQTVFYDILVKITKLLTPILPHTAEEIWSYLEFETEDFVQLSELPEAQTFANQEEILD
                     TWAAFMDFRGQAQKALEEARNAKVIGKSLEAHLTVYPNEVVKTLLEAVNSNVAQLLIV
                     SDLTIAEGPAPEAALSFEDVAFTVERAAGEVCDRCRRIDPTTAERSYQAVICDHCASI
                     VEENFADAVAEGFEEK"
     gene            38978..39340
                     /locus_tag="AC0DU4_000658"
                     /pseudo
     CDS             38978..39340
                     /locus_tag="AC0DU4_000658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000842495.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            39875..>40221
                     /locus_tag="AC0DU4_000659"
     CDS             39875..>40221
                     /locus_tag="AC0DU4_000659"
                     /EC_number="5.4.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006703946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004619 - phosphoglycerate mutase activity
                     [Evidence IEA];
                     GO_function: GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="2,3-bisphosphoglycerate-dependent
                     phosphoglycerate mutase"
                     /protein_id="HIN4236658.1"
                     /translation="MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIK
                     EAGIEFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAA
                     EQFGDEQVHIWRRS"
BASE COUNT        12597 a         7001 c         8701 g        11922 t
ORIGIN      
        1 gtcagtctta tctacaacct caaaacagtg ttttgagcat catgcggcta gcttcttagt
       61 ttgctctttg attttcattg agtataaaaa cagatgagtt tctgttttct ttttatggac
      121 tataaatgtt cagctgaaac tactttcaag gacattatta tataaaagaa ttttttgaaa
      181 ctaaaatcta ctatattaca ctatattgaa agcgttttaa aaataaggta taataaattt
      241 actaacactt ataaaaagtg atagaatcta tctttatgta tatttaaaga tagattgctg
      301 taaaaatagt agtagctatg cgaaataaca gatagagaga agggattgaa gcttagaaaa
      361 ggggaataat atgatattta aggcattcaa gacaaaaaag cagagaaaaa gacaagttga
      421 actacttttg acaatttttt tcgacagttt tctgattgat ttatttcttc acttatttgg
      481 gattgtcccc tttaagctgg ataagattct gattgtgagc ttgattatat ttcccattat
      541 ttctacaagt atttatgctt atgaaaagct atttgaaaaa gtgttcgata aggattgagc
      601 aggaagtatg gtataaatag cataagctga tgtccatcat ttgcttataa agagatattt
      661 tagtttaatt gcagcggtgt cctggtagat aaactagatt ggcaggagtc tgattggaga
      721 aaggagaggg gaaaattggc accaatttga gatagtttgt ttagttcatt tttgtcattt
      781 aaatgaactg tagtaaaaga aagttaataa aagacaaact aagtgcattt tctggagtaa
      841 atgtcttatt tcagaaatcg ggatatagat atagagagga tcagtatgaa tcggagtgtt
      901 caagaacgta agtgtcgtta tagcattagg aaactatcgg taggagcggt ttctatgatt
      961 gtaggagcag tggtatttgg aacgtctcct gttttagctc aagaaggggc aagtgagcaa
     1021 cctctggcaa atgaaactca actttcgggg gagagctcaa ccctaactga tacagaaaag
     1081 agccagcctt cttcagagac tgaactttct ggcaataagc aagaacaaga aaggaaagat
     1141 aagcaagaag aaaaaattcc aagagattac tatgcacgag atttggaaaa tgtcgaaaca
     1201 gtgatagaaa aagaagatgt tgaaaccaat gcttcaaatg gtcagagagt tgatttatca
     1261 agtgaactag ataaactaaa gaaacttgaa aacgcaacag ttcacatgga gtttaagcca
     1321 gatgccaagg ctccagcatt ctataatctc ttttctgtgt caagtgctac taaaaaagat
     1381 gagtacttca ctatggcagt ttacaataat actgctactc tagaggggcg tggttcggat
     1441 gggaaacagt tttacaataa ttacaacgat gcacccttaa aagttaaacc aggtcagtgg
     1501 aattctgtga ctttcacagt tgaaaaaccg acaccagaac tacctaaagg ccgagtgcgc
     1561 ctctacgtaa acggggtatt atctcgaaca agtctgaaat ctggcaattt cattaaagat
     1621 atgccagatg taacgcatgt acaaatcgga gcaaccaagc gtgccaacaa tacggtttgg
     1681 gggtcaaatc tacagattcg gaatctcact gtgtataatc gtgctttaac accagaagag
     1741 gtacaaaaac gtagtcaact ttttaaacgc tcagatttag aaaaaaaact acctgaagga
     1801 gcggctttaa cagagaaaac ggacatattc gaaagcgggc gtaacggtaa accaaataaa
     1861 gatggaatca agagttatcg tattccagca cttctcaaga cagataaagg aactttgatc
     1921 gcaggtgcag atgaacgccg tctccattcg agtgactggg gtgatatcgg tatggtcatc
     1981 agacgtagtg aagataatgg taaaacttgg ggtgaccgag taaccattac caacttacgt
     2041 gacaatccaa aagcttctga cccatcgatc ggttcaccag tgaatatcga tatggtgttg
     2101 gttcaagatc ctgaaaccaa acgaatcttt tctatctatg acatgttccc agaagggaag
     2161 ggaatctttg gaatgtcttc acaaaaagaa gaagcctaca aaaaaatcga tggaaaaacc
     2221 tatcaaatcc tctatcgtga aggagaaaag ggagcttata ccattcgaga aaatggtact
     2281 gtctatacac cagatggtaa ggcgacagac tatcgcgttg ttgtagatcc tgttaaacca
     2341 gcctatagcg acaagggtga tctatacaag ggtgaccaat tactaggcaa tatctacttc
     2401 acaacaaaca aaacttctcc atttagaatt gccaaggata gctatctatg gatgtcctac
     2461 agtgatgacg acgggaagac atggtcagcg cctcaagata ttactccgat ggtcaaagcc
     2521 gattggatga aattcttggg tgtaggtcct ggaacaggaa ttgtacttcg gaatgggcct
     2581 cacaagggac ggattttgat accggtttat acgactaata atgtatctca cttagatggc
     2641 tcgcaatctt ctcgtgtcat ctattcagat gatcatggaa aaacttggca tgctggagaa
     2701 gcggtcaacg ataaccgtca ggtagacggt caaaagatcc actcttctac gatgaacaat
     2761 agacgtgcgc aaaatacaga atcaacggtg gtacaactaa acaatggaga tgttaaactc
     2821 tttatgcgtg gtttgactgg agatcttcag gttgctacaa gtaaagacgg aggagtgact
     2881 tgggagaagg atatcaaacg ttatccacag gttaaagatg tctatgttca aatgtctgct
     2941 atccatacga tgcataatgg aaaagaatac attatcctca gcaatgcagg tggaccgaaa
     3001 cgtgaaaatg ggatggtcca cttggctcgt gtcgaagaaa atggtgagtt gacttggatc
     3061 aaacacaatc caattcaaaa aggagagttt gcctataatt cgctccaaga attaggaaat
     3121 ggggagtatg gcatcttgta tgaacatact gaaaaaggac aaaatgccta taccctatca
     3181 tttagaaaat ttaattggga ctttttgagc aaagatctga tttctcctac cgaagcgaaa
     3241 gtgaagcgaa ctagagagat gggcaaagga gagatgggca aaggagttat tggcttggag
     3301 ttcgactcag aagtattggt caacaaggct ccaacccttc aattggcaaa tggtaaaaca
     3361 gcgactttcc taacccagta tgatagcaag accttgttat ttgcagtaga taaggaagat
     3421 atcggacagg aaattattgg tatagctaaa ggaagcatcg aaagtatgca taatcttcct
     3481 gtaaatctag caggtgccag agttcctggc ggagtaaatg gtagcaaagc agcggtgcat
     3541 gaagttccag aatttacagg gggagttaat ggtacagagc cagctgttca tgaaatcgca
     3601 gagtataagg gatctgattc gcttgtaact cttactacaa aagaagatta tacttacaaa
     3661 gctcctcttg ctcagcaggc acttcctgaa acaggaaaca aggagagtga cctcctagct
     3721 tcactaggac taacagcttt cttccttggt ctgtttacgc tagggaaaaa gagagaacaa
     3781 taagagaaga attctaaaca tttgattttg taaaaataga aggagatagc aggttttcaa
     3841 gcctgctatc tttttttgat gacattcagg ctgatacgaa atcataagag gtctgaaact
     3901 actttcagag tagtctgttc tataaaatat agtagattga aataagatgt gaacaactct
     3961 atcaggaaag tcaaattaat ttatagaaaa attttagcag tcaaggtgta ctgttataga
     4021 ttcaatatat tatgcgacta ttaaccttgt cttctcctaa aattgacttt cttgttttct
     4081 tatcttgtcc actcgaaaca agtattgtaa gaatttgatt atttttgaaa gtacttttaa
     4141 tatacttgat atagttaaaa aagatttgaa actaaattcc aaattagaaa aagacttgaa
     4201 atactaaaaa aaaaaagtat actctaattg aaaacggtaa caaaactaat ttagagaatg
     4261 aaatatagag tatttctctc ttaaaagttt ttggtgaaac gagatgtaga aaggagattt
     4321 agccaaagag tctattagtg ctagaataat agattagaat tattttagaa aaacgaagtg
     4381 agcagcttat aaattcaagt ccccaaatag attcatacta gtatcttttg caaaaaataa
     4441 agggcgactt ccttcatgaa tatcaatttc atctataagg aaggtagcta attgaactaa
     4501 cttatttatt ctgtttgtcg ctagaaaaat cagacctcct tgtgaagatt gaggagatac
     4561 ttaatgaaaa tcaaagaaga aactagcaag ctagtagcag attgcccaaa acaccgcttt
     4621 gaggttgtag ataagactga cgtatataat ccaaggtgaa gcgactgtgg tttgaagaga
     4681 ttttcaaaga gtataggcta gagagtagtg tttttatgtc cttctagtag aaaatgctag
     4741 acagaagaat ggggaacttg gataggaaaa atagattgag aaaggaggtt agaagagatg
     4801 attattacaa aaattagccg tttaggaact tatgtgggag taaatccaca ttttgcaaca
     4861 ttaatagatt ttctagaaaa aacaggacta gaaaatttaa cagaaggttc gattgttatc
     4921 gatggtaatc gattgtttgg gaattgattt acttatctag cagatggtca agcaggggct
     4981 ttctttgaaa cacaccaaaa atatttggat attcatttag ttttggaaaa cgaagaagcc
     5041 atggctgtta catcgccgga aaatgtaagc gttacccaag aatatgatga agagaaagat
     5101 attgaattat acacagggaa agtggaacag ttggttcatt tgagagctgg cgaatgcctc
     5161 atcacttttc cagaagattt acatcaaccc aaggttcgta taaatgatga acctgtgaaa
     5221 aaagttgtct ttaaagttgc gatttcttaa tgtagaaaga gaagaacgat gaaaaaaatg
     5281 agaaagtttt tatgtctagc tggaattgcg ctagcggctg ttgccttggt agcttgttca
     5341 ggaaaaaaag aagctacaac tagtactgaa ccaccaacag aattatctgg tgagattaca
     5401 atgtggcact cctttactca aggaccccgt ttagaaagta ttcaaaaatc agcagatgct
     5461 ttcatgcaaa agcatccaaa aacgaaaatc aagattgaaa cattttcttg gaatgacttc
     5521 tatactaaat ggactacagg tttagcaaat ggaaatgtgc cagatatcag tacagctctt
     5581 cctaaccaag taatggaaat ggtcaactca gatgctttgg ttccgctaaa tgattctatc
     5641 aagcgtattg gacaagataa atttaacgaa actgccttaa atgaagcaaa aatcggagat
     5701 gattactact ctgttcctct ttattcacat gcacaagtca tgtgggttag aacagatttg
     5761 ttaaaagaac ataatattga ggttcctaaa acttgggatc aactctatga agcttctaaa
     5821 aaattgaaag aagctggagt ttatggcttg tctgttccgt ttggaacaaa tgacttaatg
     5881 gcaacacgtt tcttgaactt ctacgtacgt agtggtggag gaagcctctt aacaaaagat
     5941 cttaaagcag acttgacaag ccaacttgct caagatggta ttaaatactg ggttaaattg
     6001 tataaagaaa tctcacctca agattctttg aactttaatg tccttcaaca agctaccttg
     6061 ttctatcaag gaaaaacagc atttgacttt aactctggct tccatatcgg aggaattaat
     6121 gccaacagtc ctcaattgat tgattcgatt gatgcttatc ctattccaaa aatcaaagag
     6181 tctgataaag accaaggaat tgaaacctca aacattccaa tggttgtttg gaaaaattca
     6241 aaacatccag aagttgctaa agcattctta gaagcacttt ataatgaaga agactacgtt
     6301 aaattccttg attcaactcc agtaggtatg ttgccaacta ttaaggggat tagcgattct
     6361 gcagcctata aagaaaatga aactcgtaag aagtttaaac atgctgaaga agtaattact
     6421 gaagctgtta aaaaaggtac tgctattggt tatgaaaatg gaccaagtgt acaagctggt
     6481 atgttgacta accaacacat tattgaacaa atgttccaag atatcattac aaatggaaca
     6541 gatcctatga aagcagcaaa agaagcagaa aaacaattaa acgatttatt tgaggctgtt
     6601 cagtagatgt aaaagactag aaaataggtg ggctagtgag ctgaaaagct ctagcccaat
     6661 cttgtaaaag aagggagaag gagaatggtt aaagaacgta atttaactcg ctggatattt
     6721 gttttgccag ctatgattat cgtaggatta ctctttgttt atccgttttt ctcgagtatt
     6781 ttttatagct ttaccaataa gcatttgatt atgcctaatt ataaatttgt tggtttggct
     6841 aactataaag ctgtgctatc agatcccaac ttctttaatg cgttctttaa ttcaattaag
     6901 tggaccgttt tctcattagt tggtcaagtt ttagtagggt ttgtattggc tttagctctt
     6961 cacagagtac gccacttcaa gaaattatat aggaccttat tgattgttcc ttgggcattt
     7021 cctaccatcg ttattgcctt ttcttggcag tggattctaa acggggttta tggctactta
     7081 cctaatctaa tcgtaaaatt aggtttaatg gaacatacac ctgcattttt gacagatagt
     7141 acatgggcat tcctatgttt ggtgtttatc aacatttggt ttggagcacc aatgattatg
     7201 gttaatgtgc tttcagcttt gcaaacagta ccagaagaac aatttgaggc tgctaagata
     7261 gatggtgctt caagttggca ggtgttcaag tttatcgtct ttccacatat taaagtggtt
     7321 gtaggacttc tagttgtttt gagaactgta tggatcttta ataactttga cattatctac
     7381 ctcattactg gtggtggacc agccaatgct acaacgacgc ttccaatttt tgcttacaac
     7441 ctgggttggg gaactaaatt gttgggtcgt gcttcagcag ttacagtatt gctctttatc
     7501 ttcttggtgg cgatttgctt tatctacttt gctatcatca gtaagtggga aaaggagggt
     7561 agaaaataat gaagaagaaa tccagtattt atttagatat tctctcacat gtacttttag
     7621 ttggtgcgac catcgttgca attttcccat tggtatggat tatcatatct tctgtcaaag
     7681 ggaaagggga attaactcag tatccaacac gattttggcc tgaacagttt acattagatt
     7741 atttcactca tgttatcaac gatttgcact tcattgataa cattcgaaac agtttaatca
     7801 ttgccttggc tacaaccctc attacgatta ttatttctgc tatggcagcc tatggtattg
     7861 ttcgattctt tcctaaattg ggagcaatca tgtcgagact actcgtcatt acctatattt
     7921 tcccaccaat tttgttagca attccctatt caattgccat tgctaaagtt gggttaacaa
     7981 atagtttatt tggcttgatg atggtttatc tatcttttag tgttccatat gcagtttggc
     8041 tcttagttgg atttttccaa acagttccaa ttggaattga agaagcggct agaattgatg
     8101 gtgcaaataa atttgttacg ttttataaag ttgtgctacc gattgtagca ccaggtattg
     8161 tagcaacagc tatttataca tttatcaatg cttggaatga attcctgtat gccttgattt
     8221 tgattaacaa tacaggaaag atgacagtag cagtagccct tcgttcactt aatggttcag
     8281 aaatactaga ctggggagat atgatggcag cgtctgttat tgtagttctt ccatcaatta
     8341 ttttcttctc tatcatccaa aataagattg caagtggatt atcagaagga tctgtgaagt
     8401 agacgaaaga aggaaaaaaa atgaataaaa gaggtcttta ttcaaaacta ggaatttctg
     8461 ttgtaggcat tagtctttta atgggagttc ctactttgat tcatgcgaat gaattaaact
     8521 atggtcaact gtccatatct cctatttttc aaggaggttc atatcaactg aacaataaga
     8581 gtatagatat cagctctttg ttattagata aattgtctgg agagagtcag acagtagtaa
     8641 tgaaatttaa agcagatgaa ccaaactctc ttcaagcttt gtttggccta tctaatagta
     8701 aagcaggctt taaaaataat tacttttcaa ttttcatgag agattctggt gagataggtg
     8761 tagaaataag agacgcccaa aagggaataa attatttatt ttctagacca gcttcattat
     8821 ggggaaagca taaaggacag gcagttgaaa atacactagt atttgtatct gattctaaag
     8881 ataaaacata cacaatgtat gttaatggaa tagaagtgtt ctctgaaaca gttgatacat
     8941 ttttgccaat ttcaaatata aatggtatag ataaggcaac actaggagct gttaatcgtg
     9001 aaggtaagga acattacctc gcaaaaggaa gtattgatga aatcagtcta tttaacaaag
     9061 caattagtga tcaggaagtt tcaaatattc ccttgtcaaa tccatttcag ttaattttcc
     9121 aatcaggaga ttctactcaa gctaactatt ttagaatacc gacactatat acattaagta
     9181 gtggaagagt tctatcaagt attgatgcac gttatggtgg gactcatgat tctaaaagta
     9241 agattaatat tgccacttct tatagtgatg ataatgggaa aacgtggagt gagccaattt
     9301 ttgctatgaa gtttaatgac tatgaggagc agttagttta ctggccacga gataataaat
     9361 taaagaatag tcaaattagt ggaagtgctt cattcataga ttcatccatt gttgaagata
     9421 aaaaatctgg gaaaacgata ttactagctg atgttatgcc tgcgggtatt ggaaataata
     9481 atgcaaataa agccgactca ggttttaaag aaataaatgg tcattattat ttaaaactaa
     9541 agaagaatgg agataacgat ttccgttata cagttagaga aaatggtgtc gtttatgatg
     9601 aaacaactaa taaacctaca aattatacta taaatgataa gtatgaagtt ttggagggag
     9661 gaaagtcttt aacagtcgaa caatattcgg ttgattttga tagtggctct ttaagagaaa
     9721 aacataatgg aaaacaggtc cctatgaatg ttttctacaa agattcgtta tttaaagtga
     9781 ctcctactaa ttatatagca atgacaacta gtcagaatag aggagagagt tgggaacaat
     9841 ttaagttgtt gcctccgttc ttaggagaaa aacataatgg aacttactta tgtcccggac
     9901 aaggtttagc attaaaatca agtaacagat tgatttttgc aacatatact agtggagaac
     9961 taacctatct catttctgat gatagtggtc aaacatggaa gaaatcctca gcttcaattc
    10021 cgtttaaaaa tgcaacagca gaagcacaaa tggttgaact gagagatggt gtgattagaa
    10081 cattctttag aaccactaca ggtaagatag cttatatgac tagtagagat tctggagaaa
    10141 catggtcgaa agtttcgtat attgatggaa tccaacaaac ttcatatggc acacaagtat
    10201 ctgcaattaa atactctcaa ttaattgatg gaaaagaagc agtcattttg agtacaccaa
    10261 attctagaag tggccgtaag ggaggtcaat tagttgttgg tttagtcaat aaagaagatg
    10321 atagtattga ttggaaatac cactatgata ttgatttgcc ttcgtatggt tatgcctatt
    10381 ctgcgattac agaattgcca aatcatcaca taggtgtgct gtttgaaaaa tatgattcgt
    10441 ggtcgagaaa tgaattgcat ttaagcaatg tagttcagta tatagatttg gaaattaatg
    10501 atttaacaaa ataaaggaga aaaaacatgg ttaaatacgg tgttgttgga gcagggtatt
    10561 ttggagctga attggctcgc tacatgcaaa agaatgatgg agcagagatt actcttctct
    10621 atgatccaga taatgcagag gcgattgcag aagaattggg agcaaaagta gcaagttcct
    10681 tagatgagtt ggtttctagc gatgaagtag attgtgttat cgtcgcaact ccaaataatc
    10741 ttcataagga accggttatt aaggctgcac agcatggtaa aaatgttttc tgtgaaaaac
    10801 caattgcgct ttcttatcaa gattgtcgcg agatggtaga tgcgtgtaaa gaaaacaatg
    10861 taacctttat ggcaggacat attatgaatt tctttaatgg tgttcatcat gcaaaagaac
    10921 tcattaatca aggagttatc ggagacgttc tatattgtca tacagctcgt aatggttggg
    10981 aagaacaaca accgtcagta tcatggaaaa aaattcgtga aaaatcaggt ggtcacttgt
    11041 atcaccacat ccatgaattg gattgcgttc aattccttat ggggggcatg cctgaaactg
    11101 taaccatgac aggtggaaat gtggcccatg aaggtgaaca tttcggtgat gaagatgata
    11161 tgatttttgt caatatggaa ttttctaata agcgttttgc cttgttagaa tggggttcag
    11221 cttatcgttg gggtgaacat tatgtcttaa tccaaggaag caaaggtgcc atccgcttag
    11281 acttattcaa ctgtaaagga actcttaagc tagatgggca agaaagctat ttcttgattc
    11341 acgaatcgca agaagaagat gatgatcgga ctcgtatcta tcatagtaca gagatggatg
    11401 gagcaattgc ttatggtaaa ccaggtaaac gtactccatt atggctatca tctgtcattg
    11461 ataaagaaat gcgctatctg catgagatta tggaaggagc cccagtatca gaagaatttg
    11521 caaaactttt gacaggtgaa gctgccctag aagcaattgc tactgcagat gcttgtaccc
    11581 agtctatgtt tgaagatcgc aaagtaaaat tgtcagaaat tgtaaaataa attttggtat
    11641 tctcctattt ataggtcgac ttgctcctct gaaagtactt ttagaggagc tgtttgactt
    11701 tgctagtttt tgaaactgaa atctattata ctacaaacta ttgaaagcgt tttaatttta
    11761 aggtataata atctcataga aataaagaaa aggaggaaag aggatgccac agattagcaa
    11821 agaagccttg attgagcaaa tcaaagatgg aatcatcgtt tcttgtcagg ctcttcctca
    11881 tgaaccgctt tatacagaag cgggaggggt gattcccttg ctggtcaaag cggctgagca
    11941 aggtggagca gtcggtatcc gagcaaacag tgttcgcgat atcaaggaaa ttaaggaagt
    12001 cactaaactt ccaatcattg ggattatcaa acgtgattat ccacctcagg aacccttcat
    12061 cacggctact atgaaagaag ttgatgaatt ggcagaactg gacatcgagg tgattgctct
    12121 ggattgtacc aagcgtgaac gctacgatgg tttggaaatt caagagttca ttcgtcaggt
    12181 taaggagaaa tatcctaatc agcttttgat ggctgatact agtatcttcg aagaagggct
    12241 agcagctgta gaagcaggaa ttgactttgt cggaacaacc ttatcaggct acacatccta
    12301 cagtccaaaa gtagacggtc cagattttga attgattaag aaactctgtg atgccggtgt
    12361 agatgtcatt gcagaaggaa aaattcatac accagaacaa gccaaacaaa tccttgaata
    12421 tggagtgcga ggcatcgttg ttggtggcgc cattactaga ccaaaagaga ttacagaacg
    12481 cttcgttgct agtcttaaat aagatgtgag agggagtttt atgtttaaag ttttacaaaa
    12541 agttggaaaa gcttttatgt tacctatagc tatacttcct gcagcaggtc tacttttggg
    12601 gattggtggt gcactttcaa acccaaccac gatagcaact tatccaatac tagacaatag
    12661 tatttttcaa tcaatattcc aagtaatgag ctctgcagga gaggttgtat tcagtaattt
    12721 gtcactactt ctctgtgtgg gattatgtat tggcttagcg aaacgagata aaggaaccgc
    12781 tgcgttagca ggagtaactg gttacttagt tatgactgca acgatcaaag ctttggtaaa
    12841 actttttatg gcagaaggat ctgcaattga tactggagtt attggagcat tagttgtcgg
    12901 aatagttgcc gtatatttgc acaaccgata taacaatatt caattacctt ccgctttagg
    12961 attctttgga ggttcacgct tcgttcctat tgttacatcg ttctcttcta tcttgattgg
    13021 ctttgtcttc tttgttattt ggccaccttt ccaacaactt cttgtttcta caggtggata
    13081 tatttctcag gcgggtccaa ttggaacttt tctatatgga tttttaatga gactttctgg
    13141 agcagtaggc ttacatcata taatttaccc tatgttttgg tatactgaac ttggtggtgt
    13201 tgaaactgtt gcaggacaaa cagtggttgg agctcaaaaa atattttttg ctcaattagc
    13261 cgatccggcc cattctggat tatttacaga aggaacaagg ttttttgcag gtcgtttctc
    13321 aacaatgatg ttcggtttac cggctgcctg tttagcgatg taccatagtg ttcctaaaaa
    13381 tcgtcgtaaa aaatacgcgg gtttgttttt tggagttgct ttaacatctt ttattaccgg
    13441 tattacagaa ccaattgaat ttatgtttct attcgtcagt ccggttctat atgttgttca
    13501 cgcattcctt gatggtgtta gcttctttat tgcagacgtc ttaaatattt caataggaaa
    13561 cacattttca ggaggtgtaa tcgatttcac tttatttgga attttgcagg ggaacgctaa
    13621 gacgaattgg gttcttcaga ttccaattgg acttatttgg agtgttttgt attatattat
    13681 ttttagatgg ttcattactc aattcaacgt tctaacgcca ggacgaggag aagaagtaga
    13741 ttctaaagaa atttctgaat ccgcagattc aacttcaaat actgcagatt atttaaaaca
    13801 ggatagccta caaattatca gagccttggg tggatcaaat aatatagaag atgtagatgc
    13861 ttgtgtgaca cgtttacgtg tagctgtaaa agaagttaat caagttgata aagcactttt
    13921 aaaacaaatt ggtgcagttg atgtcttaga agtgaagggt ggcattcaag caatctatgg
    13981 agcaaaagca atcttatata aaaatagtat taatgaaatt ttaggtgtag atgattaagt
    14041 acttactgac ttaataaaaa acagaggaga gtgatggatg agtaggatga aatgaaatcg
    14101 tatacaagaa ataaagaact cattatccaa gttggatacg cttattacat aggagaatac
    14161 aaatgaaatt tagaaaatta gcttgtacag tacttgcggg tgctgtggtt cttggtcttg
    14221 ctgcttgtgg caattctggc ggaagtaaag atgctgccaa atcaggtggt gacggtgcca
    14281 aaacagaaat cacttggtgg gcattcccag tatttaccca agaaaaaact ggtgacggtg
    14341 ttggaactta tgaaaaatca atcatcgaag cgtttgaaaa agcaaaccca gatataaaag
    14401 tgaaattgga aaccatcgac ttcaagtcag gtcctgaaaa aatcacaaca gccatcgaag
    14461 caggaacagc tccagacgta ctctttgatg caccaggacg tatcatccaa tacggtaaaa
    14521 acggtaaatt ggctgagttg aacgacctct tcacagatga atttgttaaa gatgtcaaca
    14581 atgaaaacat cgtacaagca agtaaagctg gagacaaggc ttatatgtat ccgattagtt
    14641 ctgccccatt ctacatggca atgaacaaga aaatgttaga agatgctgga gtagcaaacc
    14701 ttgtaaaaga aggttggaca actgatgatt ttgaaaaagt attgaaagca cttaaagaca
    14761 agggttacac accaggttca ttgttcagtt ctggtcaagg gggagaccaa ggaacacgtg
    14821 cctttatctc taacctttat agcggttctg taacagatga aaaagttagc aaatatacaa
    14881 ctgatgatcc taaattcgtc aaaggtcttg aaaaagcaac tagctggatt aaagacaatt
    14941 tgatcaataa tggttcacaa tttgacggtg gggcagatat ccaaaacttt gccaacggtc
    15001 aaacatctta cacaatcctt tgggcaccag ctcaaaatgg tatccaagct aaacttttag
    15061 aagcaagtaa ggtagaagtg gtagaagtac cattcccatc agacgaaggt aagccagctc
    15121 ttgaatacct tgtaaacggg tttgcagtat tcaacaataa agacgacaag aaagtcgctg
    15181 catctaagaa attcatccag tttatcgcag atgacaagga gtggggacct aaagacgtag
    15241 ttcgtacagg tgctttccca gtccgtactt catttggaaa actttatgaa gacaaacgca
    15301 tggaaacaat cagcggctgg actcaatact actcaccata ctacaacact attgatggat
    15361 ttgctgaaat gagaacactt tggttcccaa tgttgcaatc tgtatcaaat ggtgacgaaa
    15421 aaccagcaga tgctttgaaa gccttcactg aaaaagcgaa cgaaacaatc aaaaaagcta
    15481 tgaaacaata gtccttagtt attctataaa aagtagtttt ttaaagaacc taagagtgta
    15541 tacccccttt tccctctaca cagatagtgt aagaaaaggg ggcttttgtt taaaatgtaa
    15601 gaaactgtca cgaaattaaa atgaagttct tacataagcg aatcataaaa aatttcattt
    15661 tgattttaaa acagttcaag aaagtcaaaa aattattcta tttgaaagag aggtgccgac
    15721 tgtgaaagtc aataaaatcc gtatgcggga aacagtgatt tcctacgctt tcctagcacc
    15781 agtattattc ttctttgtca tctttgtgtt ggctccgatg gtgatgggct tcattacaag
    15841 tttctttaac tactcaatga ctaaatttga gtttgtaggc ttggataact atatccgtat
    15901 gtttaaagat cctgtcttta caaaatctct gattaacaca gttattttgg ttattggatc
    15961 tgtaccagtt gttgttctat tctcactctt tgtagcatct cagacctatc atcaaaatgt
    16021 cattgccaga tccttctacc gtttcgtctt cttccttcct gttgtaacgg gtagtgttgc
    16081 cgtgacagtt gtttggaaat ggatttatga cccactatca gggattctaa actttgtcct
    16141 taagtcaagc cacatcatca gccaaaacat ttcttggttg ggagataaaa actgggcatt
    16201 gatggcgatt atgattattc tcttgaccac ttcagttggt cagcccatca tcctttatat
    16261 cgctgccatg gggaatattg acaattcact ggttgaagcg gcgcgtgttg atggtgcaac
    16321 tgagtttcaa gttttttgga agattaaatg gccaagcctt cttccaacaa ctctttatat
    16381 tgcaatcatc acaacaatta actcattcca gtgtttcgcc ttgattcagc ttttgacatc
    16441 tggtggtcca aactactcaa caagtacctt gatgtactac ctttacgaaa aagccttcca
    16501 attgacagaa tacggctatg ccaacacaat tggtgtcttc ttggcagtca tgattgctat
    16561 cgtaagcttt gttcaattta aagtacttgg aaacgacgta gaatactaaa gaaaggagac
    16621 agctatgcaa tctacagaaa aaaaaccatt aacagccttt actgttattt caacaatcat
    16681 tttgctcttg ttgactgtgc tgttcatctt tccattctac tggattttga caggggcatt
    16741 caaatcacaa cctgatacaa ttgttattcc tcctcagtgg ttccctaaaa tgccaaccat
    16801 ggaaaacttc caacaactca tggtgcagaa ccctgccttg caatggatgt ggaactcagt
    16861 atttatctca ttggtaacca tgttcttagt ctgtgcaacc tcatctctag caggttatgt
    16921 attggctaaa aaacgtttct atggtcaacg cattctattt gctatcttta tcgctgctat
    16981 ggcacttcca aaacaagttg tccttgtacc attggtacgt atcgtcaact tcatgggaat
    17041 ccacgatact ctctgggcag ttatcttgcc tttgattgga tggccattcg gtgtcttcct
    17101 catgaaacag ttcagtgaaa atatccctac agagttgctt gaatcagcta aaatcgacgg
    17161 ttgtggtgag attcgtacct tctggagtgt agccttcccg attgtgaaac cagggtttgc
    17221 agcccttgca atctttacct tcatcaatac ttggaatgac tacttcatgc aattggtaat
    17281 gttgacttca cgtaacaatt tgaccatctc acttggggtt gcgaccatgc aggctgaaat
    17341 ggcaaccaac tatggtttga ttatggcagg agctgccctt gctgctgttc caatcgtcac
    17401 agtcttccta gtcttccaaa aatccttcac acagggtatt actatgggag cggtcaaagg
    17461 ataatactct gcgaaaatcg aatgcaaact acgtcagctt caccttgcca tacttaagta
    17521 ttgcctgtgg ttagcttcct agtttgttct tcaattttca ttgagtatag gaaaatcaat
    17581 ctatcaagat acagaagtat attttataga tttagagaat atagaagtta taagtgtcta
    17641 caaaatggag ggtatgcagt tactttatga agttttgtca gacacttatc aacttaagaa
    17701 tggttttagt taactatcag aaacgaagga aagagtatga tttttgacga tttgaaaaac
    17761 atcacctttt acaaagggat tcatcccaat ttagacaagg ctatcgacta cctctaccaa
    17821 catcgtaaag attcattcga attaggaaag tatgagattg atggagataa agtctttcta
    17881 gttgttcagg aaaatgtcct caatcaagtt gagaataatc aatttgaaca ccataagaac
    17941 tatgcagatt tgcatttgct gatagaaggg catgaatatt cgagctacgg ttcacgtatc
    18001 aaagacgagg cagtagcatt cgacgaagcg agtgacattg gctttgttca ttgttatgaa
    18061 cactacccac tcttattggg ttatcacaat tttgcgattt tcttcccagg tgagccacat
    18121 cagccaaatg gttatgcagg catggaagaa aaggttcgaa aatatctctt taaaatcttg
    18181 attgattaaa aataggatga attgtttttt tgtaaagctt tgataatact ctaccatgaa
    18241 attgatcttt gtgaggtaga gaaatgagaa taaaatattt aaaaattggt atcttctaag
    18301 tatgctgcaa gagctagttt cttggatgga cagggaatta cagttgatga gatggcttgg
    18361 ataattaggg gcattgtgaa tgcattgatt ggtagataca taaaattagg tgcttatgcg
    18421 gctaagtatg gtattagtat ggcacgctcg atcttaagta gggcagctgc aactgcagca
    18481 gcaagagtag gattatcgac caagatttct ggatggattt tacgagtagc tgtgaatgta
    18541 gctgatgtat atggtaattt tgcctacaat attgctgcag cttgggatgc acatgataaa
    18601 atccctaaca atggtcgtat aaacttttaa aatgcgagaa tgaaagcact ttgtattttt
    18661 ttattgaata tgttagcttg gacagtgctt gcaatgataa ttcgtggagg gctagatgga
    18721 tttaatgagc atacttggag tactatttta attgcttcgc tgttcggggt atatgattat
    18781 aagcccatag ataaaaatag aaaaaagtcc aaaagaaaaa agaaaaaata gatttgttca
    18841 tggtagggac ttatgaaagc tttactgaca aaaaagaaaa cagtttacaa agaaaaatga
    18901 tggaggagca aacatggcac aaaaaggagt aagccttatc aaggcagcat ttgatacaga
    18961 caactttctc atgcgtttta gtgagaaagt cttggacatc gtgacagcca atcttctttt
    19021 tgtcgtctct tgtttgccca tcgtgacgat tggagtggct aaaatcagcc tctacgagac
    19081 catgttcgaa gttaagaaga gcagacgggt gcctgttttt aaaatctatc taagatcttt
    19141 caagcaaaat ctgaaactag gtcttcagct gggtttaatg gagttaggaa ttgtgtttct
    19201 taccctttca gatctctatc ttttctgggg tcaaacagct ctgcccttcc aattgctgaa
    19261 agccatttgt ttaggtattc tgatttttct tactatcgtg atgctggcta gttaccctat
    19321 cgcggcacgt tatgacctat cttggaaaga aattcttcaa aaaggattga tgttggctag
    19381 ttttaacttt ccttggttct tcctcatgtt agccattctt gtcctcattg tgatggttct
    19441 ttatctgtcc gccttcagtc tactcttagg tggctcagtc ttcctacttt ttgggtttgg
    19501 actattggtc tttatccaga ctggattgat ggagaaaatt ttcgcaaaat accaatagga
    19561 gctttatttc tgaaactact ttcaaaggct ccaaacgcta ttctataagc gagaaactaa
    19621 aatctaagtg tctataagat attgaaagcc ttttcgggaa agtgtatact aaagaagtaa
    19681 agaaaaatct gctttagcag aaaataaaaa taataggaga aaatctatgt cagatttgaa
    19741 aaaatacgaa ggtgtcattc cagccttcta cgcatgttat gatgatcaag gagaagtaag
    19801 cccagaacgt acgcgtgcct tggttcaata cttcattgat aaaggtgttc aaggtcttta
    19861 tgtcaatggt tcttctggtg aatgtatcta ccaaagcgtt gaagatcgca agttgatttt
    19921 ggaagaagtc atggcggtag ccaaaggtaa attgaccatc attgctcatg ttgcctgcaa
    19981 caatactaaa gacagtatgg aacttgctcg ccatgctgaa agcttgggag tagatgctat
    20041 tgcaacgatt ccaccaattt acttccgctt gccagaatac tcagttgcca aatactggaa
    20101 cgatatcagt tctgcagctc caaacacaga ctacgtgatt tacaacattc ctcaattggc
    20161 aggggttgct ttgactccaa gcctttacac agaaatgttg aaaaatcctc gtgttatcgg
    20221 tgttaagaac tcttctatgc cagttcaaga tatccaaacc tttgtcagcc ttggtgggga
    20281 agaccatatc gtctttaacg gtccagatga acagttccta ggtggccgcc tcatgggtgc
    20341 taaggctggt atcggtggta cttatggtgc tatgccagaa ctcttcttga aactcaatca
    20401 gttgattgcg gataaggacc tagaaacagc gcgtgaattg cagtatgcta tcaacgcaat
    20461 cattggtaaa ctcacttctg ctcatggaaa tatgtacggt gtcattaaag aagttttgaa
    20521 aatcaatgaa ggcttgaata ttggatctgt tcgttcacca ttgacaccag tgactgaaga
    20581 agatcgtcca gttgtagaag cggctgctgc cttgattcgt gaaaccaagg agcgcttcct
    20641 ctaatctaaa aggaggtatt tatgacatac tacgttgcaa ttgatatcgg tggaaccaac
    20701 atcaagtatg gtttggttga tcaagagggg caacttcttg aatcgcatga aatgccaact
    20761 gaggcgcata agggtggacc tcatatctta caaaagacca aagatatcgt agctagttat
    20821 ttagaaaaag gcctagtagc aggtgttgcc atatcttctg ctgggatggt ggatccggat
    20881 aagggtgaga ttttctatgc tgggccgcaa atccctaact acgcaggcac ccagttcaaa
    20941 aaggaaatcg aagaaagctt tactattcct tgtgagattg aaaatgatgt caactgtgca
    21001 ggtcttgctg aggcagtatc tggttcaggc aagggagcaa gtatgacact ttgcttgacc
    21061 attggaacag gtatcggtgg ttgcttgatt atggatagga aagtcttcca tggttttagc
    21121 aattcagcct gtgaagtcgg gtatatgcat atgcaggatg gagcttttca agacttggct
    21181 tctacaacag ctttagtgaa atatgtagct gaagcccatg gagaagatgt tgatcagtgg
    21241 aatggccgta gaattttcaa agaagccact gaaggaaaca aaatctgcat ggaaggtatt
    21301 gaccgtatgg ttgactatct aggaaaaggt ctggcaaata tttgctacgt tgccaatcca
    21361 gaagtggtta ttcttggtgg tggtatcatg gggcaagagg ctatcctcaa acctaagatt
    21421 cgcacagcct tgaaagaggc tttggtacca agtttagcag aaaaaacacg attagaattt
    21481 gcccatcacc aaaatacagc agggatgttg ggtgcatatt atcattttaa gacaaaacaa
    21541 tcctagtttg gctcagccaa actaggattt tcttacacgt ttttgtctac gatagccgtt
    21601 gagtttttta ttttcccagt agctattaaa gattttttcc ttgctttcgc gattgatttc
    21661 caaaaagtag gcataaatca aatcgataaa gaagagcata ggaagttgag cggatattcg
    21721 ttggatatag gagggttggc tgtgggtggc tacaagaaca gtctctgtat aggtctggct
    21781 atttttattg ggaacacttg taaagagtac agtctttgcc cccatctcct tggcatctaa
    21841 tagactatct aaaatagaag gagttgagcc tgaaagtgag aagcccagta ctagacaatt
    21901 ttcatccatg atgctggttg tccaggcaaa gccgtcttgg tctgtcaaag cttcgcagac
    21961 cacgcctagt cgcataaaac gtaatttcat ttcacgggcg acgagaccag aactccctgt
    22021 tccaaagaag tagatacgct cagcatcttc gattagctgg gcaattcgtt ctagttggat
    22081 ttcgtcaatc aagtcttgtg tttgttccct catattgcta taacttctga ggactcgttt
    22141 ggtcagtgga ctgtgcttgg agacttggtt ggcttgattt tctgcctgat gttggtattg
    22201 gaaaataaat tctcggtagc cagtaaagcc acacttttta gcaaagcggg tcaaagcagc
    22261 ttgagaaata tgtaattttt gggtgacttg ttgagaagat aaatcatctg taatcgtttc
    22321 agcttgcaaa aaatagcgag cgatttcttg ctctaggtct gtcatttctt caaaatgtga
    22381 atcaatgata gttgcgatat ctggtttgtc catagggaaa gctcctttac atgagtcata
    22441 ctggaagact agatcaggga atagtcacac ttcattataa cacataatat aaggatagat
    22501 aaataaaaac gcatttctgt tttaaaaacg aaaaaatcga aaaagcttct ctcttttcca
    22561 taattttcta ctcaaattgt ggtacaatta agagtaagat tttaagttag aaatgagact
    22621 gatttgtatg agaaaattta acagccattc gattccgatt cggcttaatt tattgttttc
    22681 aatcgtcatt ttactcttta tgaccattat tggtcgtttg ttgtatatgc aggttttgaa
    22741 caaggatttt tacgaaaaaa agctagcctc agctagtcag accaagatta caagcagttc
    22801 agcccgtggg gaaatttatg atgctagtgg aaaacctttg gtagaaaata cgttaaagca
    22861 ggttgtttcc tttacgcgta gcaataaaat gacggctaca gacttaaaag aaacagctaa
    22921 aaagttactg acttatgtga gcatcagttc tccaaatttg acagaacgcc agctggcgga
    22981 ttactatttg gctgatcctg aaatctataa aaaaacagtg gaagctctcc caagcgagaa
    23041 acgcttggat tcagatggaa atcgtctatc cgaatcagaa ctgtataaca atgcggtcga
    23101 tagtgtccaa acaagtcaac taaactatac agaggatgaa aagaaagaaa tctatctttt
    23161 tagtcagtta aatgctgttg gaaactttgc gacaggaacc attgctacag atcctctaaa
    23221 tgattctcag gtggctgtta ttgcctctat ttcaaaggag atgcctggca ttagtatttc
    23281 tacttcttgg gatagaaagg ttttggaaac ttccctttct tctatagttg ggagtgtatc
    23341 cagtgaaaaa gctggtctcc cagcggaaga agcagaagcc tatcttaaaa aaggctattc
    23401 tctaaatgac cgtgtaggaa cctcctattt ggaaaagcaa tatgaagaga ccttacaagg
    23461 aaaacgatcg gtaaaagaaa tccatctgga taaatatggc aatatggaaa gcgtggatac
    23521 aattgaggaa ggtagtaagg gaaacaatat caaactgacc attgatttgg ccttccaaga
    23581 tagcgtggat gctttgctga aaagttattt caattctgag ctagaaaatg gtggagccaa
    23641 gtattctgaa ggtgtctatg cagtcgccct taacccaaaa acaggtgcgg ttttgtctat
    23701 gtcagggatt aaacatgact tgaaaacagg agagttgacg cctgattcct tgggaacggt
    23761 aaccaatgtc tttgttccag gttcggttgt caaggcggcg accatcagct caggttggga
    23821 aaatggagtc ttgtcaggaa accagacctt gacagaccag tccattgtct tccaaggttc
    23881 agctcccatc aattcttggt atactcaggc ttacggttca ttccctatca cagcggtcca
    23941 agctctggag tattcatcaa atacctatat ggtccaaaca gccttaggtc ttatggggca
    24001 aacctatcaa cccaatatgt ttgtcggcac cagcaatcta gagtctgcta tggagaaact
    24061 gcgttcaacc tttggcgaat atggcttggg tactgcgaca ggaattgacc taccagatga
    24121 atctactgga tttgttccca aagagtatag ctttgctaat tacattacta atgcctttgg
    24181 gcagtttgat aactatacgc cgatgcagtt ggctcagtat gtagcaacta ttgcaaatga
    24241 tggtgttcgt gtggctcctc gtattgttga aggcatttat ggtaataatg ataagggagg
    24301 actgggtgac ttgattcagc aactgcaacc gacagagatg aataaggtca atatatccga
    24361 ctccgatatg agcatcttgc accaaggttt ttatcaggtt gcccatggta ctagtgaatt
    24421 gacaactgga cgtgcctttt caaatggtgc cttggtatcc attagcggaa aaacaggtac
    24481 agccgaaagc tatgtggcag atggtcagca agcaaccaat accaatgcgg tggcctatgc
    24541 cccatctgat aatccccaaa tcgctgtcgc agtggtcttt cctcataata ccaatctaac
    24601 aaatggtgta ggaccttcca ttgcacgtga cattatcaat ctgtatcaaa aataccatcc
    24661 aatgaactag aaaggaaatt atgctttatc caacacctat tgccaagttg attgacagtt
    24721 attctaagtt accaggtatc gggattaaga cggctacgcg tctggccttt tatacgattg
    24781 ggatgtctgc tgatgatgtc aatgaatttg caaaaaatct cctttctgct aagagagaat
    24841 tgacatattg ttctatttgt ggacgtttga cagacgacga tccttgttct atctgtactg
    24901 atccgactcg tgaccagaca acaattttag ttcttgagga tagtagagat gtggcagcca
    24961 tggaaaatat ccaagaatac catggactct atcatgtcct tcatggcctc atttctccta
    25021 tgaatggtat cagtccggac gatatcaatc tcaagagcct tatgactcgt cttatggata
    25081 gtgaggtttc agaagtgatt gtggcgacta atgctacagc ggatggtgaa gcgacttcca
    25141 tgtatctttc acgtttgctc aagccggctg gtatcaaggt tacgcgtcta gcacgaggtc
    25201 tcgctgtggg agcggacatt gagtatgcgg acgaagtgac actcttacga gccattgaaa
    25261 atcggacaga gttgtaagtg taggcaaatt tacgaactcc attcatttat aaaaaatcaa
    25321 agaggctgga aatcgttcct atcggcctct ttttgtatag tgtgatgagt aggatcaggt
    25381 tcaagtttta aaaaaccaag caaatatgat atactaaaga gcgagtattc tagtagaatt
    25441 aggacaaata atatgaaaca aacgattatt cttttatatg gtggacggag tgcggaacgc
    25501 gaagtctctg tcctttcagc tgagagtgtc atgcgtgcgg tcgattacga ccgcttcaca
    25561 gtcaagactt tctttatcag tcagtcaggt gactttatca aaacacagga atttagtcat
    25621 gctccggggc aagaagaccg tctcatgacc aatgaaacca ttgattggga taagaaagtt
    25681 gcaccaagtg ctatctacga agaaggtgca gtggtctttc cagtccttca cgggccaatg
    25741 ggagaagatg gctctgttca aggattcttg gaagttttga aaatgcctta cgttggttgc
    25801 aacattttgt catcaagtct tgccatggat aaaatcacga ctaagcgtgt tctggaatct
    25861 gctggtattg cccaagttcc ttatgtggct atcgttgaag gcgatgatgt gactgctaaa
    25921 atcgctgaag tggaagaaaa attggcttat ccagtcttca ctaagccgtc aaacatgggg
    25981 tctagtgtcg gtatttctaa gtctgaaaac caagaagaac tccgtcaagc cttagaactt
    26041 gccttccgat atgatagccg tgtcttggtt gagcaaggag tgaatgcccg tgaaattgag
    26101 gttggcctct tgggtaacta cgatgtcaag agcacgctac caggagaagt tgtcaaggac
    26161 gttgcctttt atgactacga tgccaagtat attgataaca agattactat ggatattcct
    26221 gccaaaatca gtgatgatgt ggtggctgtc atgcgtcaaa atgcagaaac agccttccgt
    26281 gccattggtg gccttggtct atctcgttgc gatttcttct atacagataa gggagagatt
    26341 tttctcaacg agctcaatac catgccaggt ttcacccagt ggtctatgta cccactactt
    26401 tgggacaata tggggatcag ctacccagaa ctaatcgagc gtttggttga ccttgccaag
    26461 gaaagttttg acaagcgcga agcgcatttg atataaaatg aaagagaggg tagaagccag
    26521 aaccatcact gcaaggtgac tagagttctc ggacttcagc cctttttaaa ggagtagaaa
    26581 tgaaattaac aatccatgaa attgcccaag ttgttggagc caaaaatgat atcagtatct
    26641 ttgaggacac ccagttagaa aaagctgagt ttgatagtcg tttgattgga actggagatt
    26701 tatttgtgcc acttaaaggt gcgcgtgatg gccatgactt tattgaaaca gcctttgaaa
    26761 atggtgcagc agtaaccttg tctgagaaag aggtctcaaa tcatccttac attctagtag
    26821 atgatgtttt gacagccttt caatccctag catcctacta tcttgaaaaa acgactgttg
    26881 atgtctttgc tgttacaggt tcaaatggca agacaacgac taaggatatg ttggcgcatt
    26941 tactgtcaac aagatacaag acctacaaaa cacaaggcaa ttacaataac gagattggcc
    27001 ttccttacac agttcttcat atgcctgaag ggacagaaaa gttggtcttg gagatggggc
    27061 aggatcactt gggagatatt catctcttgt ctgaactggc tcgtccaaaa acagccatcg
    27121 tgaccttggt tggagaagct catttggcct ttttcaaaga tcgttctgag attgctaaag
    27181 gaaaaatgca aattgcggac ggaatggctt caggttcctt gcttttagcg ccggctgacc
    27241 ctatcgtaga ggactatttg ccaactgata aaaaagtggt tcgttttggg caaggggcag
    27301 agctggaaat tactgacttg gttgagcgca aagatagtct gaccttcaag gccaatttct
    27361 tagagcaagc ccttgatttg ccagtaactg gtaagtacaa tgctaccaat gctatgattg
    27421 catcctatgt tgccctacaa gaaggagttt cagaggagca aatccgtttg gccttccaag
    27481 gtcttgaatt gacgcgtaat cgtactgagt ggaagaaagc agccaatgga gcagatatcc
    27541 tgtcagacgt atataatgcc aatccaactg ctatgaagct gattttagag actttctctg
    27601 ccattccagc caatgaaggt ggcaagaaaa ttgcagtgtt ggcggatatg aaggagcttg
    27661 gtgaccagtc tattcaactc cataaccaga tgattttgag cctttcgcca gatgtgcttg
    27721 ataccgttat tttctatgga gaagacattg ctgaattagc ccaattggcc agtcaaatgt
    27781 tcccaattgg ccacgtttac tacttcaaga aaacagaaga ccaagaccaa tttgaagacc
    27841 tagtcaagca ggtcaaggaa agcctcagtg ccaatgatca aatcttgctc aagggctcta
    27901 actctatgaa cctagccatg ttggtagaaa gtttagaaaa tgaaaccaag tgattttgtt
    27961 aagtatctgc aaagaatgat tgcccttaca gatactggct taacctttac aaaagatcct
    28021 tttgaccgtg agcgctacga ggacttgcga agtctgttat ctgaaatgtt gaatcaggga
    28081 tcagacctgg atgcagaaga agtagcagaa gtcttgaaac caacttcagc ttatgcgact
    28141 cccttaatgg acgtccgtgc ttggattgtt gaggatgaga agatttgtct ggttagggga
    28201 caaggagagg atagttgggc tttgccaggt ggctttggtg aagtcggcta ttctccaact
    28261 gaaaatattc tcaaggaaat tgaagaagaa accggtttta aagccaaagt tgaaagactg
    28321 ctagctgttt ttgataccaa tcgtttccaa ctacagagca aacaatatgc aaagtttgtt
    28381 tttgaatgta agcttctcga tggacaattc caagaaaatc aagaaatcgc tgaccttcaa
    28441 ttttttgcaa ttgaccaact gccgaattta tctgaaaaac gcattaccaa ggagcaaata
    28501 gagcttcttt ggcaggttta tcaaggtcag agggagcaat atcttgacta agaagatgat
    28561 tatcgtattt ctaaattcat ttttcttaag tagcatggta taataaaatg caggaaaatt
    28621 ttgaatcatg aggaagacta gatgaattta tgggatattt tctttacgac tcaggcaacc
    28681 gagccgccca aatttgacct tttttggtat gttagcctat ttacgctctt agccttaacc
    28741 ttttatacag cccatcgcta tcgtgaaaag aaggtttacc aacgattttt ccaaatcttg
    28801 cagactgttc agttaatcct tctttatggt tggtactggg tcaatcatat gccactgtca
    28861 gaaagcctac ccttttacca ttgccgtatg gctatgtttg tggtactctt gcttcctggt
    28921 cagtccaaat ataaacaata ctttgcatta ttgggaacat ttgggacatt agcagccttt
    28981 gtttatccag tgccagatgc ttaccctttt ccacatatca ccattctatc ctttatcttt
    29041 ggtcatttag cactcttggg gaactctcta gtttatctat tgagacagta taatgcgcga
    29101 ttgctggatg tgaagggaat ttttctcatg acctttgccc taaatgcctt gatttttgtg
    29161 gtcaatttgg tgacaggtgg cgattacgga tttttgacaa aaccgccatt ggttggggat
    29221 cacggtctag tagctaatta tttacttgtt tcaattgtgc tggtagctac tatcagtttg
    29281 actaagaaaa tcttagaatt ctttttagct caagaagcag aaaaaatgat tgcaaaggaa
    29341 gcttaacaca gagctttctt ttttgctctt agagagtttt tacaagcagc ttataaaata
    29401 agaatttctg aatagacaaa ctcaaaaaat ggctgggaaa tttaggaaaa aagcaagcac
    29461 gattaaattt tttgtgttat aatattttgt gaatagctat gcctatgttt agctatggaa
    29521 taatacgaag tgcgaaactt ggaagataga gaggaagcga tgtaatggct agagaaggct
    29581 tttttacagg tctagatatt ggaacaagct ctgtcaaggt gcttgtggcc gagcagagaa
    29641 ctggtgaatt aaatgtaatt ggcgtgagta atgccaaaag taaaggtgta aaggatggaa
    29701 ttattgttga tattgatgca gcagcaactg ctatcaagtc agccatttcc caagcggaag
    29761 aaaaggcagg catttcgatt aaatcagtaa atgtcggctt gcctggtaat cttttgcagg
    29821 tagaaccaac tcaggggatg attccagtaa catctgatac taaggaaatt acggatcaag
    29881 atgttgaaaa tgttgtcaaa tcagctttga caaagagtat gacacctgac cgtgaagtca
    29941 ttacctttat tcctgaagaa tttattgtgg atggtttcca agggattcgt gacccacgtg
    30001 gcatgatggg ggttcgcctt gaaatgcgtg gtttgcttta tacaggacct cgtactatct
    30061 tgcacaattt gcgtaagacg gttgagcgtg caggtgttca ggttgaaaat gttatcattt
    30121 caccactagc aatggttcag tctgttttga acgaagggga acgtgaattt ggtgctacag
    30181 tgattgatat gggggcaggt caaacgactg tcgctacaat ccgtaatcaa gaactccagt
    30241 tcacacatat tctccaagaa ggtggagatt atgtaactaa agatatctcc aaggttttga
    30301 aaacctctcg caaattagcg gaaggcttga aactgaatta cggggaagcc tatccgcctc
    30361 ttgcaagcaa agaaaccttc caagtagagg ttattggaga agtagaagca gtcgaagtga
    30421 cggaagccta cttgtcagaa attatttctg cacgaatcaa gcacatcctt gaacaaatca
    30481 agcaagaatt agatagaagg cgtctattgg acctccctgg tggtattgtc ttaatcggtg
    30541 ggaatgccat tttaccaggt atggttgagc ttgctcagga agtctttggc gtccgtgtca
    30601 agctttatgt tccaaatcaa gttggtatcc gtaatccagc ctttgcgcat gtgattagtt
    30661 tatcagaatt tgcgggtcaa ttaacagaag ttaatctttt ggctcaggga gcgataaaag
    30721 gtgagaatga cttaagtcat cagccaatta gttttggtgg gatgctgcaa aaaacagctc
    30781 agtttgtaca atcaacgcct gttcaaccag ctcctgctcc agaagtagag ccggtggcgc
    30841 ctacagaacc aatggcggat ttccaacaag cttcacaaaa taaaccgaaa ttagcagatc
    30901 gtttccgtgg cttgatcgga agcatgtttg acgaataaag aggaaaaata aattatgaca
    30961 ttttcatttg atacagctgc tgctcaaggg gcagtgatta aagtaattgg tgtcggtgga
    31021 ggtggtggca atgccatcaa ccgtatggtc gacgaaggtg ttacaggcgt agaatttatc
    31081 gcagcaaaca cagatgtaca agcattgagt agtacaaaag ctgagactgt tattcagttg
    31141 ggacctaaat tgactcgtgg tttgggtgca ggaggtcaac ctgaggttgg tcgtaaagcc
    31201 gctgaagaaa gcgaagaaac actgacggaa gctattagtg gtgccgatat ggtcttcatc
    31261 actgctggta tgggaggagg ctctggaact ggagctgctc ctgttattgc tcgtatcgcc
    31321 aaagatttag gtgcgcttac agttggtgtt gtaacacgtc cctttggttt tgaaggaagt
    31381 aagcgtggac aatttgctgt agaaggaatc aatcaacttc gtgagcatgt agacactcta
    31441 ttgattatct caaacaacaa tttgcttgaa attgttgata agaaaacacc gcttttggag
    31501 gctcttagcg aagcggataa cgttcttcgt caaggtgttc aagggattac cgatttgatt
    31561 accaatccag gattgattaa ccttgacttt gccgatgtga aaacggtaat ggcaaacaaa
    31621 gggaatgctc ttatgggtat tggtatcggt agtggagaag aacgtgtggt agaagcggca
    31681 cgtaaggcaa tctattcacc acttcttgaa acaactattg acggtgctga ggatgttatc
    31741 gtcaacgtta ctggtggtct tgacttaacc ttgattgagg cagaagaggc ttcacaaatt
    31801 gtgaaccagg cagcaggtca aggagtgaac atctggctcg gtacttcaat tgatgaaagt
    31861 atgcgtgatg aaattcgtgt aacagttgtc gcaacgggtg ttcgtcaaga ccgcgtagaa
    31921 aaggttgtgg ctccacaagc tagatctgct actaactacc gtgagacagt gaaaccagct
    31981 cattcacatg gctttgatcg tcattttgat atggcagaaa cagctgaatt gccaaaacaa
    32041 aatccacgtc gtttggaacc aactcaggca tctgcttttg gtgattggga tcttcgccgt
    32101 gaatcgattg ttcgtacaac agattcagtc gtttctccag tcgagcgctt tgaagcccca
    32161 atttcacaag atgaagatga attggataca cctccatttt tcaaaaatcg ttaagtaaat
    32221 gaatgtaaaa gaaaatacag aacttgtttt tcgagaagtt gcagaggcta gtctgagtgc
    32281 tcatcgagag agtggttcgg tctctgtcat tgcagttacc aagtatgtag atgtaccgac
    32341 agcggaagcc ttgcttccgc taggtgttca tcatatcggt gaaaatcgtg tagataagtt
    32401 tctggaaaaa tatgaagctt taaaagatcg agatgtgact tggcatttga ttggtacctt
    32461 gcaaagacgt aaggtgaaag atgtcattca atacgttgat tatttccatg cattggactc
    32521 agtaaagcta gcaggggaaa ttcaaaaaag aagtgaccga gtcatcaagt gtttccttca
    32581 agtaaatatt tctaaagaag aaagcaaaca cggtttttcg agagaggaac tgctggaaat
    32641 cttgccagag ttagccagac tagataagat tgaatatgtt ggtttaatga cgatggcacc
    32701 ttttgaggct agcagtgagc agttgaaaga gattttcaag gcgacccaag atttacaaag
    32761 agaaattcaa gagaaacaaa ttccaaatat gcctatgacc gagttaagta tgggaatgag
    32821 tcgtgattat aaagaagcga ttcaattcgg ttccactttt gttcgtatag gtacatcatt
    32881 ttttaagtag gagagaacca tgtctttaaa agatagattc gatagattta tagattattt
    32941 tacggaggat gaggattcaa gtctccctta tgaaaaaaga gatgagcctg tgtttactcc
    33001 agtaaattct tcacaggaac cggctctccc aatgaatcaa ccttcacagt cggctggtac
    33061 aaaagagaac aatatcacca gacttcatgc aagacaacag gaattggcaa atcagagtca
    33121 gcgtgcaacg gataaggtca ttatagatgt tcgttatcct agaaaatatg aggatgcaac
    33181 agaaattgtt gatttattgg caggaaacga aagtatcttg attgattttc agtatatgac
    33241 agaggtgcag gctcgtcgtt gtttggacta tttggatgga gcttgtcatg ttttagctgg
    33301 aaatttgaaa aaggtagctt ctaccatgta tttgttgaca ccagtgaatg ttattgtaaa
    33361 tgttgaagat atccgtttac cagatgaaga tcaacagggt gagttcggtt ttgatatgaa
    33421 gcgaaataga gtacgataat gattttttta attcgtatga tttataatgc agtggatatt
    33481 tactccctga ttttggtagc cttcgctgtc atgtcttggt ttccaggtgc ctacgaatcc
    33541 agtttaggtc gttggattgt agcgttggtg aaaccagtgc ttgctccctt gcaacgcctg
    33601 cctttacaga tagcgggtct tgatttatct gtttgggtcg cgattgtttt ggttcgattt
    33661 ttaggagaaa acctagtgcg ttttctggcg atgataggat gaataaaggg atttattagc
    33721 atttctccat agaagatcgt ccatttcttg acaagggaat ggaatggata aagaaggtag
    33781 aagatagcta tgctcctttt ttaactcctt ttatcaatcc tcatcaggag aagctattaa
    33841 agattttggc caaaacctat ggtcttgctt gtagcagtag tggggaattc gtctcgagtg
    33901 agtatgttcg agttttatta tacccagatt atttccaacc agagttttca gattttgaaa
    33961 tatctctcca ggaaattgtg tattccaata aatttgaaca tttaacgcat gctaagattt
    34021 tagggacagt catcaatcaa ttagggattg aacggaaact ttttggagat atcctagtag
    34081 atgaagaacg ggcgcagatt atgattaatc agcagtttct tcttctcttt caagatggac
    34141 taaagaaaat tggtcgtata cctgtttcgc tggaggaacg tcctttcacc gagaaaatag
    34201 ataagctaga acagtatcga gaactggatt tatctgtgtc tagttttcga ttagatgttc
    34261 ttttatcaaa tgttttgaaa ctatctagga atcaagcaaa ccagttgatt gaaaagaaac
    34321 ttgtccaagt aaattatcat gtggtagaca aatcagatta cactgttcaa gttggagact
    34381 tgattagtgt gagaaaattt ggtcgcttga gattacttca agataaggga caaacgaaaa
    34441 aagagaagaa aaaaataacc gtccagttat tattaagtaa gtgaggaata gaatgccaat
    34501 tacatcatta gaaataaagg acaagacttt tggaactcga ttcagaggtt ttgatccaga
    34561 agaagtcgat gaatttttag atattgtggt tcgtgattac gaagatcttg tgcgtgcgaa
    34621 tcatgataaa aatttgcgta ttaagagttt agaagagcgt ttgtcttact ttgatgaaat
    34681 aaaagattca ttgagccagt ctgtattgat tgctcaggat acagctgaga gagtgaaaca
    34741 ggcggcgcat gaacgttcaa acaatatcat tcatcaagca gagcaagatg cgcaacgctt
    34801 gttggaagaa gctaaatata aggcaaacga gattcttcgt caagcaactg ataatgctaa
    34861 gaaagtcgct gttgaaacag aagaattgaa gaacaagagc cgtgtcttcc accaacgtct
    34921 caaatctaca attgagagtc agttggctat tgttgaatct tcagattggg aagatattct
    34981 ccgtccaaca gctacttatc ttcaaaccag tgatgaagcc tttaaagaag tggttagcga
    35041 agtacttgga gaaccgattc cagttccaat tgaagaagaa ccaattgata tgacacgtca
    35101 gttctctcaa gcagaaatgg aagaattaca agctcgtatt gaggtagccg ataaagaatt
    35161 gtctgaattt gaagctcaga ttaaacagga agtggaagct ccaactcctg tagtgagtcc
    35221 tcaagttgaa gaagagcctc tgctcatcca gttggcccaa tgtatgaaga accagaagta
    35281 gctccagtgc atccgacagg tccaacacca gctacagaaa ctgttgattc agcaccggga
    35341 tttgaagcac cgcaagaatc tgttacaatt ttataagaaa tattctgaga acaatatctt
    35401 atccttatat tcccagcgag caggagatgg tgtgagtcct gcattcccta tcgataagat
    35461 tatcctctca aaaactcaag tctgaatcta gtaagatttg acgttcccca cgttacggga
    35521 taagagggag aaagactaaa actttttccg aataaaggtg gtaccacgat tttcgtcctt
    35581 tttggaagtt gtggttttta atttgttatt atttataaag gagataccat gaaactcaaa
    35641 gacaccctta atcttgggaa aactgaattc ccaatgcgtg caggccttcc taccaaagag
    35701 ccagtttggc aaaaggaatg ggaagatgca aaactttatc aacgtcgtca agaattgaac
    35761 caaggaaaac ctcatttcac cttgcatgat ggccctccat acgctaacgg aaatatccac
    35821 gttggacatg ctatgaacaa gatttcaaaa gatattattg ttcgttctaa gtctatgtca
    35881 ggattttacg caccatttat tcctggttgg gatactcatg gtctgccaat cgagcaagta
    35941 ttgtcaaaac aaggtgtcaa acgtaaagaa atggacttgg ttgagtactt gaaactttgc
    36001 cgtgagtacg ctctttctca agtagataaa caacgtgaag attttaaacg tttgggtgtt
    36061 tctggtgact gggaaaatcc atatgtgacc ttgactcctg actatgaagc agctcaaatt
    36121 cgtgtatttg gtgagatggc taataagggt tatatctacc gtggtgccaa gccagtttac
    36181 tggtcatggt catctgagtc agcccttgct gaagcagaga ttgaatacca tgacttggtt
    36241 tcaacttccc tttactatgc caacaaggta aaagatggca aaggagttct agatacagat
    36301 acttatatcg ttgtctggac aacgactcca tttaccatca cagcttctcg tggtttgacg
    36361 gttggtgcag atattgatta cgttttggtt caacctgctg gtgaagctcg taagtttgtc
    36421 gttgctgctg aattattgac tagcttgtct gagaaatttg gctgggctga tgttcaagtt
    36481 ttggaaactt accgtggcca agaactcaac cacatcgtaa cagaacaccc atgggataca
    36541 gctgtagaag agttggtaat tcttggtgac cacgttacga ctgactctgg tacaggtatt
    36601 gttcatacag cccctggttt tggtgaggac gattacaatg ttggtattgc taataatctt
    36661 gaagtcgcag tgactgttga tgaacgtggt atcatgatga agaatgctgg tcctgaattt
    36721 gaaggtcaat tctatgaaaa ggtagttcca actgtgattg aaaaacttgg taacctcctt
    36781 cttgcccaag aagaaatctc tcactcatat ccatttgact ggcgtactaa gaaaccaatc
    36841 atctggcgtg cagttccaca atggtttgcc tcagtttcta aattccgtca agaaatcttg
    36901 gacgaaattg aaaaagtgaa attccactca gaatggggta aagtccgtct ttacaatatg
    36961 atccgtgacc gtggtgactg ggttatctct cgtcaacgtg cttggggtgt tccacttcct
    37021 atcttctacg ctgaagatgg tacagctatc atggtagctg aaactattga acacgtagct
    37081 caactttttg aagaacatgg ttcaagcatt tggtgggaac gtgatgccaa agacctcttg
    37141 ccagaaggat ttactcatcc aggttcacca aacggcgagt tcaaaaaaga aactgatatc
    37201 atggacgttt ggtttgactc aggttcatca tggaatggag tggtggtaaa ccgtcctgaa
    37261 ttgacttacc cagccgacct ttacctagaa ggttctgacc aataccgtgg ttggtttaac
    37321 tcatcactta tcacatctgt tgccaaccat ggcgtagcac cttacaaaca aatcttgtca
    37381 caaggttttg cccttgatgg taaaggtgag aagatgtcta aatctcttgg aaataccatt
    37441 gctccaagcg atgttgaaaa acaattcggt gctgaaatct tgcgtctctg ggtaacaagt
    37501 gttgactcaa gcaatgacgt gcgtatctct atggatattt tgagccaagt ttctgaaact
    37561 taccgtaaga ttcgtaacac tcttcgtttc ttgattgcca atacatctga ctttaaccca
    37621 gctcaagata cagtcgctta cgatgagctt cgttcagttg ataagtacat gacgattcgc
    37681 tttaaccagc ttgtcaagat cattcgtgat gcctatgcag actttgaatt cttgacgatc
    37741 tacaaggcct tggtgaactt tatcaacgtt gacttgtcag ccttctacct tgattttgcc
    37801 aaagatgttg tttacattga aggtgccaaa tcactggaac gccgtcaaat gcagactgtc
    37861 ttctatgaca ttcttgtcaa aatcaccaaa ctcttgacac caatccttcc tcacactgcg
    37921 gaagaaattt ggtcatatct tgagtttgaa acagaagact tcgtccaatt gtcagaatta
    37981 ccagaggctc aaacttttgc taatcaagaa gaaatcttgg atacatgggc agccttcatg
    38041 gacttccgtg gacaagctca aaaagccttg gaagaagctc gtaatgcaaa agtaatcggt
    38101 aaatcacttg aagcacactt gacagtttat ccaaacgaag ttgtgaaaac tctactcgaa
    38161 gcagtaaaca gcaatgtggc tcaacttttg atcgtgtcag acttgaccat cgcagaagga
    38221 ccagctccag aagctgccct tagcttcgaa gatgtagcct tcacagttga acgcgctgca
    38281 ggtgaagtat gtgaccgttg ccgtcgtatt gacccaacaa cagcagaacg tagctaccag
    38341 gcagttatct gtgaccactg tgcaagtatc gtagaagaaa actttgcaga tgcagtcgca
    38401 gaaggatttg aagagaaata agattgaaaa gtctaggcaa aattcaattt gagaagaaaa
    38461 gacaactaat tttatagtct attaaacgca ttgtatcacg tttttgaaca cctgatatga
    38521 tgcgtttttt atttttaaaa tttgcaaggt gtgacttttt atactcatac tcaatgaaaa
    38581 tcaaaaagca aactaggaag ctagccgcag gctgctcaaa acactgtttt gaggttgtag
    38641 ataagactga cgaagtcagt aacatatata tggtaaggcg acgctgacgt ggtttgaaga
    38701 gattttcgaa gagtatcaac aagaatcaaa gagaaactta gcaagctaac agtagtaaga
    38761 taaaatagga atttgatatt agggataaga ttggtaaata gtgtaatatt tttacaacaa
    38821 taaatttata tagttatttc tggtttctga aaagtattat attatatttt atttcatatt
    38881 atacaaattt ttattttata atatcagaaa atactttttt taaaaagcaa atatgataca
    38941 attttatttg aaaaaaaata aaaaaggaga ttttattatg aaatcaagtg gtatcgtcgg
    39001 tcttgtggga ggaattttac ttcttatttg tccttttgtc ttgttgggaa cagcggtaaa
    39061 tacagctgct acaactctta atggaggagc tactgcaggg gctttttcag gtgttgcctt
    39121 actcttgaat accttgaaga ttgcaaatct tgttcttggt atcattgcta ttgtttacta
    39181 taaaggagat aagcatgtag gtgcagctcc gtctgtacta atgattgttt ctggtgaagt
    39241 tagtctcatt ccattcttag gatgagttgg ggggattctt gctattatcg gaggatctct
    39301 attccttgca acattgaaga aattcaaatc agaagaataa aaggtatttt agcatgaaaa
    39361 gaacaaaaaa gtttatcggt ataggagtag ctctattatc tctttctctt ctagttgcat
    39421 gtggaacata aagttcaaag aatacttcaa caagtaatga tgagaagaca gtagcaacat
    39481 ccaatagttc aaaagaaaca atcactttcg atacaccggt tgtaacagac gatgcgattg
    39541 aatcaatacg cacttatgca gattatatag atctttataa aaatattttt gatgattatt
    39601 ttactaaagc tgaggaaggt ttcaaaggca cagttatgga aaataatgac tcgtttacta
    39661 aactaaaaga gtcaactcaa aaattattcg atgcgcagaa aaaaaggtta aataatgaag
    39721 atagaataga aacagccaaa aacaatgtga ttgccaaaca ttgtcaaaca gtcctttcct
    39781 ttttggtttt gactagcttt tttgtgaaaa attgtgtaaa atagaataga taaacgaggg
    39841 gaaacctcgg aaaatttaaa ggagaatcca tctaatggta aaattggttt ttgctcgcca
    39901 cggtgagtct gaatggaaca aagctaacct tttcactggt tgggctgatg ttgatttgtc
    39961 tgaaaaaggt acacaacaag cgattgacgc tggtaaattg atcaaagaag ctggtatcga
    40021 atttgaccaa gcttacactt cagtattgaa acgtgctatc aaaacaacta acttggctct
    40081 tgaagcttct gaccaattgt gggttccagt tgaaaaatca tggcgcttga acgaacgtca
    40141 ctacggtggt ttgactggta aaaacaaagc tgaagctgct gaacaatttg gtgatgagca
    40201 agttcacatc tggcgtcgtt c
//
LOCUS       DBMVGT010000012        38438 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.012, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000012 DBMVGT010000000
VERSION     DBMVGT010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 38438)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 38438)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..38438
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.012"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1202)
                     /gene="ilvB"
                     /locus_tag="AC0DU4_000660"
     CDS             complement(<1..1202)
                     /gene="ilvB"
                     /locus_tag="AC0DU4_000660"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0003984 - acetolactate synthase activity
                     [Evidence IEA];
                     GO_function: GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="biosynthetic-type acetolactate synthase large
                     subunit"
                     /protein_id="HIN4236659.1"
                     /translation="MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIY
                     NFKGIRHILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSVPL
                     LVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITEAVHIATTGRP
                     GPVVIDLPKDISALETDFIYSPEVNLPSYQPTLEPNDMQIKKILKQLSKAKKPVLLAG
                     GGISYAEAATELNEFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSFAANIAMTE
                     ADFMISIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIISADIPVVGDAKKALQM
                     LLAEPTVHNNTEKWIEKVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDV
                     GQHQMWTA"
     gene            complement(1403..3070)
                     /locus_tag="AC0DU4_000661"
     CDS             complement(1403..3070)
                     /locus_tag="AC0DU4_000661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HIN4236660.1"
                     /translation="MSKITTSLFQEMVQAASTRLNKQAEYVNSLNVFPVPDGDTGTNM
                     GMTIENGAKEVADKPASTVGEVASILAKGLLMGARGNSGVITSQLFRGFSQAIKDKDE
                     LTGQDLALAFQSGVEVAYKAVMKPVEGTILTVSRGAAIGAKKKAEQTDDAVEVMRAAL
                     EGAKTALAKTPDMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFVATPANM
                     SEMINVEHHKSVAGHVATEDITFGYCTEIMVALKQGPTYAKDFDYDEFRNYLDELGDS
                     LLVVNDDEIVKVHVHTEDPGLVMQEGLKYGSLVKVKVDNMRNQHEAQVEKEATQVIKS
                     AEEKEYALIAVVAGKGLADIFCSQGVDYVIEGGQTMNPSTEDFIKAVEQVNARNIIFL
                     PNNKNIFMAAQSAAEVLEQPAVVVEARTLPQGMTSLLAFDPSKSIEENQERMTAALSD
                     VVSGSVTTAVRDTTIDGLEIHENDNLGMVDGKILVSNPDMHQTLTETLKHMLDEDSEI
                     VTFYVGEDGSEELANEIAQEIVEEFEDVEVEIHQGQQPVYPYLFSVE"
     gene            complement(3073..3438)
                     /locus_tag="AC0DU4_000662"
     CDS             complement(3073..3438)
                     /locus_tag="AC0DU4_000662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HIN4236661.1"
                     /translation="MTVKINTKDGQIELTDEVIATVVGGAATEIFGVVGMASKNALKD
                     NFQALLGKENYSKGVVVKAAEDGSIAVDVYTVLSYGTKISEVSKNIQERVAFSLENQL
                     GITAQTVNVYIQNIKVVGE"
     gene            complement(3595..3783)
                     /gene="rpmB"
                     /locus_tag="AC0DU4_000663"
     CDS             complement(3595..3783)
                     /gene="rpmB"
                     /locus_tag="AC0DU4_000663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008536053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HIN4236662.1"
                     /translation="MAKVCYFTGRKTVSGNNRSHAMNQTKRAVKPNLQKVTVLIDGKP
                     KKVWASARALKSGKVERV"
     gene            complement(3899..4135)
                     /locus_tag="AC0DU4_000664"
     CDS             complement(3899..4135)
                     /locus_tag="AC0DU4_000664"
                     /inference="COORDINATES: protein motif:HMM:NF013652.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HIN4236663.1"
                     /translation="MCGFFRYFIPKYVSESRVLYLDLDIVVRKSIDELWDLDLTAIPL
                     AAVRDDFYTHNFNSGVLLINNGMWRAENVTQDLI"
     gene            complement(4286..4384)
                     /locus_tag="AC0DU4_000665"
     CDS             complement(4286..4384)
                     /locus_tag="AC0DU4_000665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 8"
                     /protein_id="HIN4236664.1"
                     /translation="MKEEKKAIVLGADNAYMDKVETTIKSLCVHLL"
     gene            complement(4812..6356)
                     /locus_tag="AC0DU4_000666"
     CDS             complement(4812..6356)
                     /locus_tag="AC0DU4_000666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_process: GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 3"
                     /protein_id="HIN4236665.1"
                     /translation="MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVK
                     GKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNILDTPGHEDFSEDTYRTLMA
                     VDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILG
                     IASYPMNWPIGMGKAFEGLYDLYNKRLELYKGDERFASLEDGDKLFGSNPFYEQVKDD
                     IELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLETFLKFAPEPHGHKKTDGE
                     IVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNV
                     TQFMAESRENVTNAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVS
                     AKNVMKQKSFHKGIEQLVQEGAVQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAE
                     VVMSPMGKKTVRWIKPEDLDERMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDV
                     ELEEKM"
     gene            6569..6871
                     /gene="gatC"
                     /locus_tag="AC0DU4_000667"
     CDS             6569..6871
                     /gene="gatC"
                     /locus_tag="AC0DU4_000667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0030956 - glutamyl-tRNA(Gln)
                     amidotransferase complex [Evidence IEA];
                     GO_function: GO:0050567 - glutaminyl-tRNA synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_process: GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA];
                     GO_process: GO:0006450 - regulation of translational
                     fidelity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatC"
                     /protein_id="HIN4236666.1"
                     /translation="MKITQEEVTHVANLSKLRFSEKETAAFATTLSKIVDMVELLGEV
                     DTTGVAPTTTMADRKTVLRPDVAEEGTDRDRLFKNVPEKDNYYIKVPAILDDGGDA"
     gene            6871..8337
                     /gene="gatA"
                     /locus_tag="AC0DU4_000668"
     CDS             6871..8337
                     /gene="gatA"
                     /locus_tag="AC0DU4_000668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0030956 - glutamyl-tRNA(Gln)
                     amidotransferase complex [Evidence IEA];
                     GO_function: GO:0050567 - glutaminyl-tRNA synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA];
                     GO_process: GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatA"
                     /protein_id="HIN4236667.1"
                     /translation="MTFNNKTIEELHNLLVSKEISATELTQTTLENIKSREEALNSFV
                     TIAEEQALVQAKAIDEAGIDADNVLSGIPLAVKDNISTDGILTTAASKMLYNYEPIFD
                     ATAVANAKTKGMIVVGKTNMDEFAMGGSGETSHYGATKNAWDHSKVPGGSSSGSAAAV
                     ASGQVRLSLGSDTGGSIRQPAAFNGIVGLKPTYGTVSRFGLIAFGSSLDQIGPFAPTV
                     KENALLLSAIASEDAKDSTSAPVRIADFTSKIGQDIKGMKIALPKEYLGEGIDPEVKE
                     TILNAAKHFEKLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRAEDA
                     TNLDEIYVNSRSQGFGEEVKRRIMLGTFSLSSGYYDAYYKKAGQVRTLIIQDFEKVFA
                     DYDLILGPTAPSVAYDLDSLNHDPVAMYLADLLTIPVNLAGLPGISIPAGFSQGLPVG
                     LQLIGPKYSEETIYQAAAAFEATTDYHKQQPVIFGGDN"
     gene            8337..9779
                     /gene="gatB"
                     /locus_tag="AC0DU4_000669"
     CDS             8337..9779
                     /gene="gatB"
                     /locus_tag="AC0DU4_000669"
                     /EC_number="6.3.5.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatB"
                     /protein_id="HIN4236668.1"
                     /translation="MNFETVIGLEVHVELNTNSKIFSPTSAHFGNDQNANTNVIDWSF
                     PGVLPVLNKGVVDAGIKAALALNMDIHKKMHFDRKNYFYPDNPKAYQISQFDEPIGYN
                     GWIEVELEDGTTKKIGIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMR
                     SPEEAYAYLTALKEVIQYAGISDVKMEEGSMRVDANISLRPYGQEKFGTKTELKNLNS
                     FSNVRKGLEYEVQRQAEILRSGGQIRQETRRYDEANKATILMRVKEGAADYRYFPEPD
                     LPLFEISDEWIEEMRTELPEFPKERRARYVSDLGLSDYDASQLTANKVTSDFFEKAVA
                     LGGDAKQVSNWLQGEVAQFLNTEGKTLEQIELTPENLVEMIAIIEDGTISSKIAKKVF
                     VHLAKNGGGAREYVEKAGMVQISDPAILIPIIHQVFADNEAAVADFKSGKRNADKAFT
                     GFLMKATKGQANPQVALKLLAQELAKLKEN"
     gene            9908..10468
                     /gene="efp"
                     /locus_tag="AC0DU4_000670"
     CDS             9908..10468
                     /gene="efp"
                     /locus_tag="AC0DU4_000670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HIN4236669.1"
                     /translation="MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRD
                     VRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENE
                     LLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLV
                     VNVPDFIEAGQKLVINTAEGTYVSRA"
     gene            10490..10879
                     /locus_tag="AC0DU4_000671"
     CDS             10490..10879
                     /locus_tag="AC0DU4_000671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HIN4236670.1"
                     /translation="MGIEEQLGEIVIAPRVLEKIIAIATAKVEGVHSFSNRSVSDTLS
                     KLSLGRGIYLKNVDEELTADIYLYLEYGVKVPKVAVAIQKAVKDAVRNMADVELAAIN
                     IHVAGIVPDKTPKPELKDLFDEDFLND"
     gene            10872..11294
                     /gene="nusB"
                     /locus_tag="AC0DU4_000672"
     CDS             10872..11294
                     /gene="nusB"
                     /locus_tag="AC0DU4_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000203663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_process: GO:0006353 - DNA-templated transcription
                     termination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HIN4236671.1"
                     /translation="MTSPLLESRRQLRKCAFQALMSLEFGTDVETACRFAYTHDREDT
                     DVQLPAFLIDLVSGVQAKKEELDKQITQHLKAGWTIERLTLVERNLLRLGVFEITSFD
                     TPQMVAVNEAIELAKDFSDQKSARFINGLLSQFVTEEQ"
     gene            complement(11344..11580)
                     /locus_tag="AC0DU4_000673"
     CDS             complement(11344..11580)
                     /locus_tag="AC0DU4_000673"
                     /EC_number="3.4.26.-"
                     /inference="COORDINATES: protein motif:HMM:NF014566.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family glutamic-type intramembrane
                     protease"
                     /protein_id="HIN4236672.1"
                     /translation="MDVILSAIIFGISHLILSHRDPISLLYYSLIGFFFALVYRSTDN
                     LRLTILCHSFFNFLNHAKPIWIFVYNYIYYHFFR"
     gene            complement(11593..12066)
                     /locus_tag="AC0DU4_000674"
     CDS             complement(11593..12066)
                     /locus_tag="AC0DU4_000674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001246431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236673.1"
                     /translation="MRNTKKLRQFGIFLLIILLSTYLPQTIGLYVTIILGLGADVYSL
                     ILTMGLVGSFLLLIWRLKKKKMLFIFEKKSWNWSFVFYLFATYVVYQILGNFWARYAH
                     LINHRNIHDEYFTVLFSNGQPTFLSTILSFVLPVIIGPVFEETLDRGYFMNTFFP"
     gene            complement(12084..12269)
                     /gene="briC"
                     /locus_tag="AC0DU4_000675"
     CDS             complement(12084..12269)
                     /gene="briC"
                     /locus_tag="AC0DU4_000675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biofilm-regulating peptide BriC"
                     /protein_id="HIN4236674.1"
                     /translation="MTGTNTFTVLSTEDLEQTSGGLAVWEDGYSRWLYYREFAPYMRQ
                     GALNSYIDAWKYGFRAG"
     gene            complement(12428..13195)
                     /locus_tag="AC0DU4_000676"
     CDS             complement(12428..13195)
                     /locus_tag="AC0DU4_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyl transferase
                     subunit alpha"
                     /protein_id="HIN4236675.1"
                     /translation="MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAV
                     VGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVT
                     FINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRV
                     WMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEIGLSS
                     KELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY"
     gene            complement(13192..14058)
                     /gene="accD"
                     /locus_tag="AC0DU4_000677"
     CDS             complement(13192..14058)
                     /gene="accD"
                     /locus_tag="AC0DU4_000677"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001173351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA];
                     GO_function: GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase, carboxyltransferase
                     subunit beta"
                     /protein_id="HIN4236676.1"
                     /translation="MALFSKKDKYIRINPNRSVREKPQAKPEVPDELFSQCPGCKHTI
                     YQKDLGSERICPHCSYTFRISAQERLALTIDMGTFKELFTGIESKDPLHFPGYQKKLA
                     SMREKTGLHEAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITRLFEYATVEKL
                     PVVLFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFYLTILTDPTTGGVTASFAM
                     EGDIILAEPQSLVGFAGRRVIENTVRESLPEDFQKAEFLLEHGFVDAIVKRRDLPDTI
                     ASLVRLHGGSPR"
     gene            complement(14095..15462)
                     /gene="accC"
                     /locus_tag="AC0DU4_000678"
     CDS             complement(14095..15462)
                     /gene="accC"
                     /locus_tag="AC0DU4_000678"
                     /EC_number="6.3.4.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000488661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA];
                     GO_function: GO:0004075 - biotin carboxylase activity
                     [Evidence IEA];
                     GO_function: GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HIN4236677.1"
                     /translation="MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLL
                     ADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKF
                     IGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKAS
                     AGGGGKGIRKVKKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEH
                     GHVIHLGERDCSLQRNNQKVLEESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEF
                     LLDEASSNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGH
                     AIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKII
                     VHGENRFDALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPK
                     YQEKE"
     gene            complement(15474..15896)
                     /gene="fabZ"
                     /locus_tag="AC0DU4_000679"
     CDS             complement(15474..15896)
                     /gene="fabZ"
                     /locus_tag="AC0DU4_000679"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016836 - hydro-lyase activity [Evidence
                     IEA];
                     GO_function: GO:0019171 -
                     (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase
                     activity [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HIN4236678.1"
                     /translation="MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFF
                     NGHFPQYPVMPGVLIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGDQL
                     VMTATFVKRRGTIAVVEAKAEVDGKLAASGTLTFAIGN"
     gene            complement(15893..16378)
                     /gene="accB"
                     /locus_tag="AC0DU4_000680"
     CDS             complement(15893..16378)
                     /gene="accB"
                     /locus_tag="AC0DU4_000680"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001052236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA];
                     GO_function: GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HIN4236679.1"
                     /translation="MNLNDIKDLMTQFDQSSLREFSYKNGTDELQFSKNEARPVPEVA
                     TQVAPAPVLATPSPVAPTSAPAETVAEEVPAPAEASVATEGNLVESPLVGVVYLAAGP
                     DKPAFVTVGDSVKKGQTLVIIEAMKVMNEIPAPKDGVVTEILVSNEEMVEFGKGLVRI
                     K"
     gene            complement(16381..17616)
                     /gene="fabF"
                     /locus_tag="AC0DU4_000681"
     CDS             complement(16381..17616)
                     /gene="fabF"
                     /locus_tag="AC0DU4_000681"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HIN4236680.1"
                     /translation="MKLNRVVVTGYGVTSPIGNTPEEFWNSLATGKIGIGGITKFDHS
                     DFDVHNAAEIQDFPFDKYFVKKDTNRFDNYSLYALYAAQEAVNHANLDVEALNRDRFG
                     VIVASGIGGIKEIEDQVLRLHEKGPKRVKPMTLPKALPNMASGNVAMRFGANGVCKSI
                     NTACSSSNDAIGDAFRSIKFGFQDVMLVGGTEASITPFAIAGFQALTALSTTEDPTRA
                     SIPFDKDRNGFVMGEGSGMLVLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEG
                     QGAIKAIKLALEEAEISPEQVAYVNAHGTSTPANEKGESGAIVAVLGKEVPVSSTKSF
                     TGHLLGAAGAVEAIVTIEAMRHNFVPMTAGTSEVSDYIEANVVYGQGLEKEIPYAISN
                     TFGFGGHNAVLAFKRWENR"
     gene            complement(17638..18369)
                     /gene="fabG"
                     /locus_tag="AC0DU4_000682"
     CDS             complement(17638..18369)
                     /gene="fabG"
                     /locus_tag="AC0DU4_000682"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004316 - 3-oxoacyl-[acyl-carrier-protein]
                     reductase (NADPH) activity [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HIN4236681.1"
                     /translation="MKLEHKNIFITGSSRGIGLAIAHKFAQAGANIVLNSRGAISEEL
                     LAEFSNYGIKVVPISGDVSDFADAKRMIDQAIAELGSVDVLVNNAGITQDTLMLKMTE
                     ADFEKVLKVNLTGAFNMTQSVLKPMMKAREGAIINMSSVVGLMGNIGQANYAASKAGL
                     IGFTKSVAREVASRNIRVNVIAPGMIESDMTAILSDKIKEATLAQIPMKEFGQAEQVA
                     DLTVFLAGQDYLTGQVIAIDGGLSM"
     gene            complement(18403..19323)
                     /gene="fabD"
                     /locus_tag="AC0DU4_000683"
     CDS             complement(18403..19323)
                     /gene="fabD"
                     /locus_tag="AC0DU4_000683"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004314 - [acyl-carrier-protein]
                     S-malonyltransferase activity [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HIN4236682.1"
                     /translation="MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDL
                     RYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVASGA
                     LDFEDAVALVAKRGAYMEEAAPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYN
                     TPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTALLEPASQKLAETLAQVS
                     FSDFTCPLVGNTEAAVMQKEDIAQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGK
                     VLSGFVKKIDQTAHLAHVEDQASLVALLEK"
     gene            complement(19316..20290)
                     /gene="fabK"
                     /locus_tag="AC0DU4_000684"
     CDS             complement(19316..20290)
                     /gene="fabK"
                     /locus_tag="AC0DU4_000684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0018580 - nitronate monooxygenase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HIN4236683.1"
                     /translation="MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGG
                     NAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKY
                     MERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATA
                     VSIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDT
                     TISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVD
                     GGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND"
     gene            complement(20410..20634)
                     /locus_tag="AC0DU4_000685"
     CDS             complement(20410..20634)
                     /locus_tag="AC0DU4_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002938891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000035 - acyl binding [Evidence IEA];
                     GO_function: GO:0000036 - acyl carrier activity [Evidence
                     IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0009245 - lipid A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HIN4236684.1"
                     /translation="MAVFEKVQEIIVEELGKDASEVTLESTFDDLDADSLDLFQVISE
                     IEDAFDIQIEAENDLKTVGDLVAYVEEQAK"
     gene            complement(20694..21668)
                     /locus_tag="AC0DU4_000686"
     CDS             complement(20694..21668)
                     /locus_tag="AC0DU4_000686"
                     /EC_number="2.3.1.180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="HIN4236685.1"
                     /translation="MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRH
                     ISRTESTSDLATEVAKKLMAKAGITGKELDFIILATITPDSMMPSTAARVQANIGANK
                     AFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDG
                     AGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVF
                     DFAIRDVAKSIKQTIDESPIEVTDLDYLLLHQANDRILDKMARKIGVDRAKLPANMME
                     YGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTLILTI"
     gene            complement(21668..22102)
                     /locus_tag="AC0DU4_000687"
     CDS             complement(21668..22102)
                     /locus_tag="AC0DU4_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="HIN4236686.1"
                     /translation="MDYQRINEYLTSIFNNVLVIEEVNLRGSRFKDISIKEMHTIDVI
                     GKAPDVTPSQVSKELMVTLGTVTTSLNNLERKGYIERVRSEQDRRVVHLHLTKKGRLI
                     HRLHKRFHKAMVEKIIDGMSEEEIAVMGKGLTNLYQFLEDLK"
     gene            complement(22196..22981)
                     /locus_tag="AC0DU4_000688"
     CDS             complement(22196..22981)
                     /locus_tag="AC0DU4_000688"
                     /EC_number="4.2.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase"
                     /protein_id="HIN4236687.1"
                     /translation="MEHIIYQLEEDLAILTLNRPEVANGFHIPMCEEILEALTLAEEN
                     PAVHFILINANGKVFSVGGDLVEMKRAVDEDDIPSLTKIAELVNTISYKIKQIAKPVL
                     MEVDGAVAGAAANMAVAADFCLATDKAKFIQAFVGVGLAPDAGGIHLLSRSIGVTRAA
                     QLAMTGEALTAEKALEWGLVYRVSEAEKLEKTREQLLKKLRRASSNSYAAIKKLVWES
                     QFKDWQGYATLELNLQKSLAQTEDFKEGVRAHSERRRPKFTGK"
     gene            23351..24715
                     /locus_tag="AC0DU4_000689"
     CDS             23351..24715
                     /locus_tag="AC0DU4_000689"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004072 - aspartate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HIN4236688.1"
                     /translation="MKVVKFGGSSLASASQLEKVLNIVKSDSERRFVVVSAPGKRNAE
                     DTKVTDALIKYYRDYVAGNDISKSQSWIIDRYAAMVSELGLKPAVLEKISKSIHALAT
                     LPIEENEFLYDTFLAAGENNNAKLIAAYFNQNGIDARYMHPREAGIVVTSEPGHARII
                     PSSYDKIEELTNTNEVLVIPGFFGVTKENQICTFSRGGSDITGSIIAAGVKADLYENF
                     TDVDGIFAAHPGIIHQPHSIPELTYREMRELAYAGFSVLHDEALLPAYRGKIPLVIKN
                     TNNPDHPGTRIVLKHSNDEFPVVGIAGDSGFVSINMSKYLMNREIGFGRKVLQILEEL
                     NIGWEHMPTGIDDLSIILRSRQLTPIKEEEILRQLVQKAKVDHAEIEHDLSIIMIVGE
                     KMKSHIGVTATATRALSENKINIQMMSQGSSEVSIMFVVNKDQEKAAIKALYYAFFGE
                     SKED"
     gene            24718..25089
                     /locus_tag="AC0DU4_000690"
     CDS             24718..25089
                     /locus_tag="AC0DU4_000690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF956 family protein"
                     /protein_id="HIN4236689.1"
                     /translation="MAQSLNKTVLLSTTGTSYLSIAGKVGKFLVGDQALEFYPDVNVE
                     QFIQIPWSHINQIGANVTGRKVSRHFEVFTDKGKFLFASKDSGAILKIAREKLGNDKV
                     VKLPTLIQTISQKFKNLFAKK"
     gene            25303..26577
                     /gene="serS"
                     /locus_tag="AC0DU4_000691"
     CDS             25303..26577
                     /gene="serS"
                     /locus_tag="AC0DU4_000691"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004828 - serine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006434 - seryl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HIN4236690.1"
                     /translation="MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVK
                     VETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTT
                     TLPNIPADSVPVGTDEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
                     ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTF
                     ELSDTNFVLIPTAEVPLTNYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIR
                     LHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSAAKTY
                     DLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTV
                     AAILENYQNEDGSVTIPEALRPYMGGAEVIKP"
     gene            complement(26602..27501)
                     /locus_tag="AC0DU4_000692"
     CDS             complement(26602..27501)
                     /locus_tag="AC0DU4_000692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000735961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HIN4236691.1"
                     /translation="MKKLPLVFSGCLLGLAGAGNLILDTLPVLSHLFSLTGLVLWIYF
                     LILHLFNWKETKQELTKPPLLSGMATFPMAGMILSTYVFRVFSYLPLVAQGIWWFSFL
                     LDLTLIAGFTIKFACPGRRVHATPSWTVLYVGIAVAALTYPLVGIIEIAYATLSFGFL
                     LTFYLYPLIYSDLKKHPLPLALLGQEGIYCAPFSLLLASLVRVGGTSLPTWVLIVMIL
                     ASQSFFFFVLTRLPNILKQGFQPAFSALTFPTIITATSLKMAQGILKLPFLDYLVLAE
                     TIICLTILFFVLGAYLIWLRKKV"
     gene            complement(27611..28159)
                     /locus_tag="AC0DU4_000693"
     CDS             complement(27611..28159)
                     /locus_tag="AC0DU4_000693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000206764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="HIN4236692.1"
                     /translation="MTTFTIHTVESAPAEVKEILETVEKDNNGYIPNLIGLLANAPTV
                     LEAYQIVSSIHRRNSLTPVEREVVQITAAVTNGCAFCVAGHTAFSIKQIQMNDDLIQA
                     LRNRTPIETDPKLDTLAKFTLAVINTKGRVGDEALSEFLEAGYTQQNALDVVFGVSLA
                     ILCNYANNLANTPINPELQPYA"
     gene            complement(28377..29693)
                     /locus_tag="AC0DU4_000694"
     CDS             complement(28377..29693)
                     /locus_tag="AC0DU4_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005283 - amino acid:sodium symporter
                     activity [Evidence IEA];
                     GO_function: GO:0015293 - symporter activity [Evidence
                     IEA];
                     GO_process: GO:0006814 - sodium ion transport [Evidence
                     IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alanine/glycine:cation symporter family protein"
                     /protein_id="HIN4236693.1"
                     /translation="MLELLKSIDAFAWGPPLLILLVGTGIYLTMRLGLLQVLRLPKAF
                     QLIFIQDKGHGDVSSFAALCTALASTVGTGNIIGVATAIKVGGPGALFWMWMAAFFGM
                     ATKYAEGLLAIKYRTKDDHGAVAGGPMHYILLGMGEKWRPLAVLFAVAGVLVALLGIG
                     TFTQVNSITESIQNTTTISPAITALVLSVFVAIAVFGGLKSISKVSTTVVPFMALIYI
                     LGTLTVIFFNIGKIPGTIALVFTSAFSPLAAVGGFAGASVRMAIQNGVARGVFSNESG
                     LGSAPIAAAKTNEPVEQGLISMTGTFIDTLIICTLTGLTILVTGVWSGDLNGVALTQS
                     AFSTVFSHFGPALLTIFLVLFAFTTILGWNYYGERCFEFLFGARFIWLYRVFFVLMVL
                     LGGFIELDMVWIIADIVNALMALPNLIALLVLSPVVIAETKKYFNK"
     regulatory      complement(29784..29872)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            complement(30036..32372)
                     /locus_tag="AC0DU4_000695"
     CDS             complement(30036..32372)
                     /locus_tag="AC0DU4_000695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004519 - endonuclease activity [Evidence
                     IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0030983 - mismatched DNA binding [Evidence
                     IEA];
                     GO_process: GO:0006259 - DNA metabolic process [Evidence
                     IEA];
                     GO_process: GO:0045910 - negative regulation of DNA
                     recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HIN4236694.1"
                     /translation="MNKKILETLELDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIK
                     QAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLTSREL
                     QSFYANLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHD
                     SESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTV
                     YIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHAAEIANDAWIIGHLDLIRA
                     KVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGK
                     TIMLKTLGLTQVMAQSGLPILADKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNI
                     VDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYG
                     IETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQD
                     NDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKARE
                     QAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKVKLKKLAPEKVDLSKNKVLQKAK
                     KKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPV
                     KKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDTFIDQALLNNMAQVDIIHGIGTG
                     VIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG"
     gene            complement(32476..33024)
                     /locus_tag="AC0DU4_000696"
     CDS             complement(32476..33024)
                     /locus_tag="AC0DU4_000696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000622948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CvpA family protein"
                     /protein_id="HIN4236695.1"
                     /translation="MISFLLLLVLVWGFYIGYRRGLLLQVYYLISAMASAFMAGQFYK
                     GLGEQFHLLLPYANSQEGQGTFFFPSDQLFQLDKVFYAGIGYLLVFGIVYSIGRLLGL
                     LLHLIPSKKLGGKLFQVSAGILSMLVTLFVLQMALTILATIPMAVIQNPLEKSIVAKH
                     IIQSIPITTSWLKQIWVTNLIG"
     gene            complement(33021..33323)
                     /gene="zapA"
                     /locus_tag="AC0DU4_000697"
     CDS             complement(33021..33323)
                     /gene="zapA"
                     /locus_tag="AC0DU4_000697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein ZapA"
                     /protein_id="HIN4236696.1"
                     /translation="MANLNRFKFTFGKKSLTLTSEHDNLFMEEIAKVATEKYQAIKEQ
                     MPSADDETIALLLAVNCLSTQLSREIEFDDKEQELEELRHKLVTCKQEQSKIEDSL"
     gene            33410..34291
                     /gene="rnhC"
                     /locus_tag="AC0DU4_000698"
     CDS             33410..34291
                     /gene="rnhC"
                     /locus_tag="AC0DU4_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA];
                     GO_process: GO:0006401 - RNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HIII"
                     /protein_id="HIN4236697.1"
                     /translation="MASITLTPSEKDIQAFLEHYQTSLAPSKNPYIRYFLKLPQATVS
                     IYTSGKILLQGEGAEKYASFFGYQAVEQTSGQNLPLIGTDEVGNGSYFGGLAVVAAFV
                     TPDQHDFLRKLGVGDSKTLTDQKIRQIAPILKEKIQHQALLLSPSKYNEVIGDRYNAV
                     SVKVALHNQAIYLLLQKGVQPEKIVIDAFTSAKNYDKYLAQEANRFSNPISLEEKAEG
                     KYLAVAVSSVIARDLFLENLENLGRELGYQLPSGAGTASDKVASQILQAYGMQGLNFC
                     AKLHFKNTEKAKKRLER"
     gene            34295..34909
                     /gene="lepB"
                     /locus_tag="AC0DU4_000699"
     CDS             34295..34909
                     /gene="lepB"
                     /locus_tag="AC0DU4_000699"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006465 - signal peptide processing
                     [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HIN4236698.1"
                     /translation="MNSLKNFLKEWGLFLLILSLLALSRIFFWSNVRVEGHSMDPTLA
                     DGEILFVVKLLPIDRFDIVVAHEEDGNKDIVKRVIGMPGDTIRYENDKLYINDKETDE
                     PYLADYIKRFKDDKLQSTYSGKGFEGNKGTFFRSIAQKAQAFTVDVNYNTNFSFTVPE
                     GEYLLLGDDRLVSSDSRHVGTFKAKDITGEAKFRFWPITRIGTF"
     gene            34989..35111
                     /locus_tag="AC0DU4_000700"
     CDS             34989..35111
                     /locus_tag="AC0DU4_000700"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236699.1"
                     /translation="MKIKEQTRKLAVGCLKQWFEVVDRTDEVSSKYCFEVADGS"
     gene            35188..37554
                     /gene="recD2"
                     /locus_tag="AC0DU4_000701"
     CDS             35188..37554
                     /gene="recD2"
                     /locus_tag="AC0DU4_000701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0043139 - 5'-3' DNA helicase activity
                     [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SF1B family DNA helicase RecD2"
                     /protein_id="HIN4236700.1"
                     /translation="MEVYFSGTIERIIFENPSNFYRILLLEIDDTDAEDFDDFEIIVT
                     GTMADVIEGEDYTFWGQIVQHSKYGEQLQISRYDRAKPTSKGLVKYFSSSHFKGIGLK
                     TAQKIVDTYGENTIDEILQHPEKLEGIAGLSAKNREAFVSTLRLNYGTEMVLAKLANY
                     GIPNKLAFQIQDFYKEETLDVVENYPYQLVEDIKGLGFTIADQLAEELGIESQAPERF
                     RAGLVHSLFQACMETGDTYVEARDLLEQTLTLLESSRPVELDPSQVAQELSYLIEEDK
                     VQQIDTKIFDNSLFFAEEGIRSHLIRILEKGEQKRQDLETIQKHITTVEQELGIEYDN
                     IQKQAICDAIQNKVFILTGGPGTGKTTVINGIIAVYALLEGLDFRKKSNLPILLAAPT
                     GRAARRMNELTGLPSATIHRHLGMTGDDDTSHLEDYLDADFIIVDEFSMVDTWLTNQL
                     FSNISSNSKILIVGDSDQLPSVSPGQVLADLLHIPLIPQTRLEKIYRQSKESTIVTLA
                     SQIRQGILPADFTQKKADRSYFEIASGHIPATIEKILGVALRNGIPARDIQVLAPMYR
                     GTAGIDAINQLMQDLLNPPQKDQLSFEAPQCHYRKRDKVIHLVNDAEINVFNGDLGAI
                     TDLIPGKYTESKQDEIVIDFDGNEVSYPRNEWYKIRLAYAMSIHKSQGSEFPVVILPI
                     TSASRRMLERNLIYTAITRAKSKLILLGELQAFDYATQHIGTARKTYLIERFSDLLEN
                     VEEKQQAVSETVTSSASEQSYILTEENWDSIPAMIGITDTDLKEIFGK"
     gene            complement(37602..>38438)
                     /gene="tig"
                     /locus_tag="AC0DU4_000702"
     CDS             complement(37602..>38438)
                     /gene="tig"
                     /locus_tag="AC0DU4_000702"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005854 - nascent polypeptide-associated
                     complex [Evidence IEA];
                     GO_function: GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA];
                     GO_function: GO:0051082 - unfolded protein binding
                     [Evidence IEA];
                     GO_process: GO:0015031 - protein transport [Evidence IEA];
                     GO_process: GO:0051083 - 'de novo' cotranslational protein
                     folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HIN4236701.1"
                     /translation="LAELVIKEAAAENGDTVVIDFVGSIDGVEFDGGKGENFSLGLGS
                     GQFIPGFEDQLVGHSAGETVDVIVTFPEDYQAEDLAGKEAKFVTTIHEVKAKEVPALD
                     DELAKDIDEEVETLADLKEKYRKELAAAKEEAYKDAVEGAAIDTAVENAEIVELPEEM
                     IHEEVHRSVNEFLGNLQRQGINPDMYFQITGTTQEDLHNQYQAEAESRTKTNLVIEAV
                     AKAEGFDASEEEIQKEVEQLAADYNMEVAQVQNLLSADMLKHDITIKKAVELITSTAT
                     VK"
BASE COUNT        11141 a         8849 c         7447 g        11001 t
ORIGIN      
        1 tgagctgtcc acatttggtg ttgaccaacg tctgttacca caatggcatc tccattcgtc
       61 aattcaccaa ttcgttcaat aactgcttgc ggttgaacca cacgctcttt cttgtcataa
      121 gaacgaacac gattcttgtc tttagtgact ttctcaatcc acttttcagt attgttgtga
      181 actgttggtt ctgctagcaa catttgcaag gccttcttag catctccaac tacaggaatg
      241 tctgcactga taatcttgcc aatctcagct gggtcaatat caatgtgggc aaccttagca
      301 ttcttagcga aagtcttagg attccccgtc aaacggtcat cgaaacgaga accaatacta
      361 atcataaagt ccgcttccgt catggcaata tttgctgcga atgacccgtg catgcctccc
      421 attccaagaa agagtgggtg actcgttgca atcgttcctt gtcccaaaag actggttacc
      481 actggaattt gatagcgttc tgcaaattca tttagttccg tagcagcctc agcataacta
      541 attccaccac cagctaacaa gactggcttt ttagccttgg acaattgctt caagattttc
      601 ttgatttgca tatcattcgg ctcaagagtc ggctgataac ttggtaaatt cacttctggt
      661 gaataaatga agtctgtttc taaagcagat atgtcttttg gtaggtcaat tacaactggc
      721 cctggacggc ctgtagttgc gatatggaca gcttccgtaa tgatacgcgg aatatcagct
      781 gtctcacgaa cttggtaatt gtacttagtg attggcatgg taattcctac gatgtctgcc
      841 tcctgaaagg catccttccc aatccctgct cgcgccacct gacctgtaaa gaccaaaagg
      901 ggaacgctat cgctcatagc atccgcaatc cctgtaatgg catttgttgc tcctggtcca
      961 ctagtgacga cggcaacacc caactttcca gttgatttgg cataaccttc agcttcatgc
     1021 aaacaacctt gctcatggcg ccctagaatg tggcgaatgc ctttaaaatt atatatcgca
     1081 tcataaaaag gcaaaaccgc accaccagga taaccaaaga tggtatcaac tcctaaatca
     1141 cgaagtgttt ccaaaactag gtccgacccc gtcttaggag attctaaact gattttctcc
     1201 attgttcccc tttctttcct cttaaaaata acttgttact atcataccat tttttcaaaa
     1261 tttttcaaga taaaagaaga aattttctga attttctatt ttaacgttta tttatgaatg
     1321 ttatttttgt ttttattaaa aagataccga tttcatttac taaaaaagaa aaaagaactg
     1381 atttctcagt ccttcattaa tcttattcca cactaaatag gtatgggtaa acaggttgtt
     1441 gaccttggtg aatctcgact tcaacgtctt cgaattcttc tacgatttct tgagcgattt
     1501 cattggcaag ttcttcgctt ccgtcttcac cgacatagaa ggttacgatt tcactatctt
     1561 catccaacat atgtttcaag gtttcagtca atgtttggtg catatcaggg tttgacacaa
     1621 gaatttttcc atccaccata cctagattat cgttttcatg gatttctaag ccatcgatcg
     1681 ttgtatcacg cacggctgtt gtgacgcttc cgctaacgac atcgctaaga gcagctgtca
     1741 tacgctcttg gttttcttca atggacttgc ttggatcaaa ggcaagaaga cttgtcatac
     1801 cttgaggaag agtgcgagcc tctaccacta ctgctggttg ctccaaaact tctgccgcag
     1861 attgagctgc catgaagatg ttcttgttgt ttggcaagaa gatgatgtta cgggcattga
     1921 cctgttcaac agccttgata aagtcttctg ttgaagggtt catggtttga ccgccttcga
     1981 taacataatc cacgccttga gaacagaaga tatctgctag acctttacca gccaccacag
     2041 caatcaaagc atactctttt tcttcagccg acttgataac ttgagtagct tctttctcaa
     2101 cctgtgcttc gtgttggtta cgcatattgt caacttttac cttgaccaag ctaccatatt
     2161 tgagaccttc ttgcataaca agtcctggat cttctgtatg aacatggact ttgacaattt
     2221 catcatcgtt aacaacgagg agagaatccc caagctcatc caagtagtta cggaattcat
     2281 cgtagtcaaa atctttagca taggttggac cttgcttaag agctaccatg atttcagtac
     2341 agtaaccaaa cgtgatgtcc tcagtcgcta cgtgaccagc tacagactta tgatgctcta
     2401 cattgatcat ctcactcatg ttggcaggag tcgctacaaa gtcctcagat gcaatatatt
     2461 cgccagtaag ggctgaaagg aaaccttcgt agatgaagac caatccttga ccacctgagt
     2521 ccacaacgcc aacttctttc aatactggaa gcatgtctgg tgttttagct agagctgttt
     2581 tagcaccttc caaggctgcg cgcatgactt caacagcgtc atctgtttgc tcagcttttt
     2641 tcttagcacc gatagcagct ccacgagaaa ctgttaaaat cgttccttca acaggtttca
     2701 tcactgcctt ataggcaact tccacacctg attggaaggc cagagccaag tcttgacctg
     2761 ttaactcgtc tttatccttg atagcttggg aaaatccacg gaaaagctga gacgtaatca
     2821 ctcctgagtt cccacgcgca cccatcaaaa gccctttggc aagaatgctc gctacttctc
     2881 caactgtaga agctggcttg tctgcaactt ctttagcacc attttcaatg gtcattccca
     2941 tatttgtccc agtatctcca tctggaactg gaaagacgtt taatgaattg acatattcag
     3001 cttgcttatt caagcgagtt gatgcagcct gcaccatttc ttgaaataag ctagtagtaa
     3061 tttttgacac ggttattctc ctacaacttt gatattttga atgtagacat ttacagtctg
     3121 agcagtaatt ccaagctggt tttccaagct aaaggcaaca cgctcttgaa tgttttttga
     3181 cacttcacta atctttgttc cgtagcttaa cacggtatat acatcaactg caatactgcc
     3241 atcttcggct gcctttacga cgacaccttt agaataattt tccttaccta gcagggcttg
     3301 gaaattatct ttgagggcat ttttactagc cataccgacc acaccaaaaa tctcagttgc
     3361 tgctccacct acgacggttg caatcacttc atctgttagt tcgatttgac catcttttgt
     3421 attaattttt acagtcatcc tttttacctc aactagttga tactctattt tatcatattt
     3481 cagcccaagt gtaaaagcag aatgatgtat cagcggatat ttactctatt tttcaaacga
     3541 tgttataccc acaataaaag aaaaaagacc ctaaggtctc ctttgctttt attattaaac
     3601 gcgttcaact ttacctgatt tcaaagcacg agctgaagcc caaacttttt taggtttacc
     3661 atcgataaga acagtaactt tttgaaggtt tggttttacg gcacgttttg tttggttcat
     3721 cgcgtgtgaa cggttgtttc ctgatacagt cttacgacct gtaaagtaac atactttagc
     3781 cattgtgttt tcctcctatt agatctaata tagcggatgt gctagcacca cataccgtac
     3841 tatgttatca cactttcttg ttttttgcaa gggaattgga agatttttta tttgtgtctt
     3901 aaatcaggtc ttgcgtgaca ttttctgctc tccacatgcc attgttgatt aacagaacac
     3961 cagaattaaa attatgtgta taaaaatcat ctctaactgc agctaagggt atagccgtca
     4021 agtccaaatc ccacagctca tctatcgatt ttcttacaac aatatctaaa tccaaataca
     4081 gtacacgaga ctcgcttaca tactttggaa taaaatacct aaaaaagccg catatgaaag
     4141 tccctcaaag gggagacgat aacctttcag aatactactg tcaatctaaa cattcacaat
     4201 ctcactattc aaagtctcta gtcttttttc catcaattgg aaccattctc gcggaaggtc
     4261 atcattaaaa acataaaact taagattata atagatgaac acaaagagat tttattgttg
     4321 tttcaacttt atccatataa gcattatctg cacctaagac aatcgctttt ttctcttctt
     4381 tcactcttta tctcatttct ttttattccc atcatatgtt tctacgtaac cattattttc
     4441 gcccattcgt tcgtaaaacc ataccagtgg agattttaga tgaagtccca ttacggttta
     4501 caatttttac attacgacac ggagttttac aaatcgattt catttgccaa acgtagttag
     4561 taaggcagtt agctaggcta cctactttct gctacgacgg aaaaatccac aaatcaatac
     4621 cattcgtgga tttttcctag tgaagcgttt aggtaagccg ccatagcggt taccgattat
     4681 tagattacga cacggagttt ggcaaatcga ttctatttgc caaacgtagt tagtgaggca
     4741 gttagctagt tcgccaaata gcgactagcg tccaacaatt tggaacttta gttccaattg
     4801 ttggtactga gtcacatctt ctcctctaac tctacgtctg gatacttgtc cgcaaaccag
     4861 cggagggcaa agtcattttc aaagagaaag actggttggt caaaacggtc tttggctaag
     4921 atattgcgac ttgatgacat ccgttcatcc aaatcctcag gcttgatcca acgaacggtc
     4981 tttttaccca ttgggctcat gaccacttcc gcattatatt ctccttccat acggtgctta
     5041 aagacttcaa actggagttg acctacagcg cctagcatgt actcacctgt ttggtaattc
     5101 ttataaagct gaacggctcc ttcttgcact agttgctcaa tccccttgtg gaaggatttt
     5161 tgcttcatga cattcttagc agaaactttc atgaaaattt caggagtaaa ggttggcaat
     5221 ggttcaaatt caaatttgtt tttcccaact gtcaaggtat ccccaacctg ataagtgcct
     5281 gtatcgtaaa ccccgataat atcacctgcc acggcattgg tcacattctc acgactttcc
     5341 gccataaact gggtaacatt agacagttta gcccccttac cagtacgagg gagattaaca
     5401 ctcatgccgc gctcaaattc gccagatacg atacggacaa aggcaatacg gtcacggtga
     5461 cgagggtcca tgttggcttg gattttaaag acaaagcctg agaaatcctt gtcataagga
     5521 tccacaattt caccgtctgt tttcttgtga ccatgtggtt ctggagcaaa cttgaggaag
     5581 gtttcaagga aggtctgcac accaaagttt gtcagggctg aaccgaaaaa gacaggcgtc
     5641 aattctccag ccagaatagc ttcctctgaa aactcattcc cggcttcatt taaaagctca
     5701 atatcatcct tgacttgctc gtagaaagga ttgctaccaa aaagtttgtc cccatcttct
     5761 agactagcaa aacgctcatc ccctttataa agctctaaac gtttgttata gaggtcatac
     5821 aagccctcaa aggctttccc catcccgata ggccagttca tagggtagct agcaatgccc
     5881 aagatttctt ccaattcttg taagagatcc aaaggctcac gaccgtcacg gtccagcttg
     5941 ttcataaagg taaagactgg aatgccacga tgtttcacaa cctcaaacaa tttcttggtt
     6001 tgagcctcga tccccttggc agagtccacg accatgaccg cagcatccac cgccatcaag
     6061 gtacgatagg tatcttctga gaagtcctcg tgccctggcg tgtctaagat attcacgcgc
     6121 ttgccgtcgt agtcaaattg cataacagat gaagtaacag aaatcccacg ttgcttctcg
     6181 atatccatcc aatcagattt agcaaaagtc cctgttttct tcccttttac cgtaccagcc
     6241 tcacgaattt cacccccaaa gtagagtaac tgctcagtga tggttgtttt ccccgcgtcc
     6301 gggtgggaga taatggcaaa ggtacgacgt ttcttaattt cttcttgaat attcataagt
     6361 tctctttctt tgattctcta tttttcttgt ttcaatagct gagaatgatt tttacattgg
     6421 attttaccat tcctttcaac actccattat atcggatttt agcatttttt tcaatttcta
     6481 tttcttttca cttccccctc ccttatttat aggaaaatat ggtaaaatag aacagactaa
     6541 aaatcatcat ttcacgaaag gatgcaagat gaaaattacg caagaagagg taacacacgt
     6601 tgccaatctt tcaaaattaa gattctctga aaaagaaact gctgcctttg cgaccacctt
     6661 gtctaagatt gttgacatgg ttgaattgct gggcgaagtt gacacaactg gtgtcgcacc
     6721 tactacgact atggctgacc gcaagactgt actccgccct gatgtggccg aagaaggaac
     6781 agaccgtgat cgcttgttta aaaacgtacc tgaaaaagac aactactata tcaaggtgcc
     6841 agctatccta gacgatggag gagatgccta atgactttta acaataaaac tattgaagag
     6901 ttgcacaatc tccttgtctc taaggaaatt tctgcaacag aattgaccca aacaacactt
     6961 gaaaatatca agtctcgtga ggaagctctc aattcatttg tcaccatcgc tgaggagcaa
     7021 gctcttgttc aagctaaagc cattgatgaa gctggaattg atgctgacaa tgtcctttca
     7081 ggaattccac ttgctgttaa ggataacatc tctacagacg gtattctcac aactgctgcc
     7141 tcaaaaatgc tctacaacta tgagccaatc tttgatgcga cagctgttgc caatgcaaaa
     7201 accaagggca tgattgtcgt tggaaagacc aacatggacg aatttgctat gggtggttca
     7261 ggtgaaactt cacactacgg agcaactaaa aacgcttggg accacagcaa ggttcctggt
     7321 gggtcatcaa gtggttctgc cgcagctgta gcctcaggac aagttcgctt gtcacttggt
     7381 tctgatactg gtggttccat ccgccaacct gctgccttca acggaatcgt tggtctcaaa
     7441 ccaacctacg gaacagtttc acgtttcggt ctcattgcct ttggtagctc attagaccag
     7501 attggacctt ttgctcctac tgttaaggaa aatgccctct tgctcagcgc tattgccagc
     7561 gaagatgcta aagactctac ttctgctcct gttcgcatcg ccgactttac ttcaaaaatc
     7621 ggccaagaca tcaagggtat gaaaatcgct ttgcctaagg aatacctcgg tgaaggaatt
     7681 gatccagaag ttaaggaaac aatcttaaac gcggccaaac actttgaaaa attgggtgct
     7741 attgtcgaag aagtcagcct tcctcactct aaatacggag ttgccgtata ctacatcatc
     7801 gcttcatcag aagcttcatc aaacttgcaa cgctttgacg gtatccgtta cggctatcgc
     7861 gcagaagatg caaccaacct tgatgaaatc tatgtaaaca gccgaagcca aggttttggt
     7921 gaagaagtga agcgccgtat catgctgggt actttcagtc tttcatcagg ttactacgat
     7981 gcctactaca agaaggctgg acaggtccgt acacttatca ttcaagattt cgaaaaagtc
     8041 ttcgcggatt acgatttgat tttgggtcca actgctccaa gtgttgccta tgacttggat
     8101 tctctcaacc atgacccagt tgccatgtac ttagccgacc tattgaccat acctgtaaac
     8161 ttggcaggac tgcctggaat ttcgattcct gctggattct ctcaaggtct acctgtcgga
     8221 ctccaattga ttggtcccaa gtactctgag gaaaccattt accaagctgc tgctgctttt
     8281 gaagcaacaa cagactacca caaacaacaa cccgtgattt ttggaggtga caactaatga
     8341 actttgaaac agtcattgga cttgaagtcc acgtagagct caacaccaat tcaaaaatct
     8401 tctcacctac ttctgcccac ttcggaaatg atcaaaatgc caacactaac gtgattgact
     8461 ggtctttccc aggagttctg ccagttctca ataaaggggt tgtcgatgcc ggaatcaagg
     8521 ctgctcttgc cctcaacatg gacatccaca aaaagatgca ctttgaccgc aagaactact
     8581 tctatcctga taaccccaaa gcctaccaaa tttctcaatt tgatgaacca atcggatata
     8641 atggctggat tgaagtcgaa ctagaagacg gtacgaccaa gaaaatcggt atcgaacgtg
     8701 cccacctaga ggaagacgct ggtaaaaaca cccatggtac agatggctac tcttatgttg
     8761 acctcaaccg ccaaggggtt cccttgattg agattgtatc tgaggcagat atgcgttctc
     8821 ctgaagaagc ctatgcttat ctgacagccc tcaaggaagt tatccagtac gctggcattt
     8881 ctgacgttaa gatggaggaa ggttcgatgc gtgtggatgc caacatctcc cttcgtcctt
     8941 atggtcaaga gaaattcggt accaagactg aattgaagaa cctcaactcc ttctcaaacg
     9001 ttcgtaaagg tcttgaatac gaagtccaac gccaggctga aattcttcgc tcaggtggtc
     9061 aaatccgcca agaaacacgc cgttacgatg aagcgaataa agcaaccatc ctcatgcgtg
     9121 tcaaggaagg ggctgctgac taccgctact tcccagaacc agacctaccc ctctttgaaa
     9181 tttctgacga gtggattgag gaaatgcgga ctgagttgcc agagtttcca aaagaacgtc
     9241 gtgcgcgtta tgtatctgac cttggtttat cagactacga tgctagtcag ttgactgcta
     9301 ataaagtcac ttctgacttc tttgaaaaag ctgttgccct aggtggtgat gccaaacaag
     9361 tctctaactg gctccaaggg gaagtcgctc agttcttgaa tactgaaggt aaaacactgg
     9421 aacaaatcga attgacacca gaaaacttgg ttgaaatgat tgccatcatc gaagacggta
     9481 ctatttcatc taagattgcc aagaaagtct ttgtccatct agctaaaaat ggcggtggcg
     9541 cgcgtgaata cgtggaaaaa gcaggtatgg ttcaaatttc agatccagct atcttgatcc
     9601 caatcatcca ccaagtcttt gccgataacg aagctgctgt tgccgacttc aagtcaggca
     9661 aacgtaacgc cgacaaggcc tttacaggat tccttatgaa ggcaaccaaa ggccaagcca
     9721 acccacaagt tgcccttaaa ctacttgcac aggaattggc gaagttgaaa gaaaactaga
     9781 cagaacaaaa ccagccctaa ggttggtttt ttcttctctc ccaactccca ataactattt
     9841 tggctttatt tccagagtat tttatggtaa aatgaagagt aataatattt attaaagagg
     9901 taaaaacatg attgaagcaa gtaaattaaa agctggtatg acctttgaaa cagctgacgg
     9961 caaattgatt cgcgttttgg aagctagtca ccacaaacca ggtaaaggaa acacgatcat
    10021 gcgtatgaaa ttgcgtgatg tccgtactgg ttctacattt gacacaagct accgtccaga
    10081 ggaaaaattt gaacaagcta ttatcgagac tgtcccagct caatacttgt acaaaatgga
    10141 tgacacagca tacttcatga atacagaaac ttacgaccaa tacgaaatcc ctgtagtcaa
    10201 tgttgaaaac gaattgcttt acatccttga aaactctgat gtgaaaatcc aattctacgg
    10261 aactgaagtg atcggtgtca ccgttcctac tactgttgag ttgacagttg ctgaaactca
    10321 accatctatc aaaggtgcta ctgttacagg ttctggtaaa ccagcaacga tggaaactgg
    10381 acttgtcgta aacgttccag acttcatcga agcaggacaa aaactcgtta tcaacactgc
    10441 agaaggaact tacgtttctc gtgcctaatc tctagaaaga ggtcattcta tgggaattga
    10501 agaacaactt ggcgaaatcg ttatcgcccc acgtgtactt gaaaaaatca ttgctatcgc
    10561 tactgcaaag gtagagggtg ttcactcttt ttcaaacaga tcagtgtctg ataccctttc
    10621 aaaactttca ctcggccgtg gcatttatct taaaaacgtg gacgaagaac tcacagcaga
    10681 tatctatctc taccttgagt acggagtaaa agttcctaag gtagcggttg ctatccagaa
    10741 agctgtcaaa gatgccgtcc gtaatatggc tgatgtagaa ctcgctgcta tcaatattca
    10801 cgttgcaggt atcgtcccag ataaaacacc aaaaccagaa ttgaaagatc tatttgacga
    10861 ggacttcctc aatgactagt ccactattag aatctagacg ccaactccgt aaatgcgctt
    10921 ttcaagctct catgagcctt gagttcggta cggatgtcga aactgcttgt cgtttcgcct
    10981 atactcatga tcgtgaagat acggatgtac aacttccagc ctttttgata gacctcgttt
    11041 ctggtgttca agctaaaaag gaagaactag ataagcaaat cactcagcat ttaaaagcag
    11101 gttggaccat tgaacgctta acgctcgtgg agagaaacct ccttcgcttg ggagtctttg
    11161 aaatcacttc atttgacact cctcagatgg ttgctgttaa tgaagctatc gagcttgcaa
    11221 aggacttctc cgatcaaaaa tctgcccgtt ttatcaatgg actgctcagc cagtttgtaa
    11281 cagaagaaca ataaaaagaa aaagtgtttg atagatatca aacacttttt tctttgcctc
    11341 ccactatcta aaaaaatgat aatagatata attgtaaaca aaaatccaga taggttttgc
    11401 atgattgaga aagttaaaaa aactatggca gagaatcgtt aatctcagat tgtcggtaga
    11461 acgataaaca agggcaaaaa agaaaccaat cagactataa tataataaac taattggatc
    11521 tctgtgagat agtatcaaat ggctaatccc aaagatgata gcagatagga taacatccaa
    11581 atagtacttg gactagggaa agaaggtatt cataaaatac cctctatcaa gagtctcctc
    11641 aaaaacagga ccgatgatta caggcaggac aaaagataag atagtcgata aaaaggttgg
    11701 ttgtccattt gaaaaaagca cggtaaaata ctcatcatga atattcctat gattaatcaa
    11761 atgagcatag cgtgcccaaa aattaccgag aatctgataa accacataag ttgcaaataa
    11821 gtagaagaca aatgaccagt tccagctctt tttctcaaag ataaagagca tctttttctt
    11881 ttttaacctc caaattaata gaaggaaact tcccactaat cccattgtta aaataagaga
    11941 atagacatca gctcctaacc ctaaaatgat cgtcacatac aatccaattg tttgtggtaa
    12001 ataggtagat agtaaaataa taagcaaaaa tattccaaat tgtcttagtt tttttgtgtt
    12061 tctcatcgta cttttttgaa agattaccct gctcggaagc cgtacttcca agcatctata
    12121 taagaattaa gtgccccttg cctcatatag ggagcaaatt ctctataata taaccatcta
    12181 ctatatccat cttcccaaac agcaagacca cctgaagttt gctccaagtc ctcagttgaa
    12241 agaactgtaa atgtatttgt acctgtcatt gcaagtacct tcttaaaata gattgttgta
    12301 ggttcacatt tatagtatat ttcttttttt gtctatttta tagcccatct cctcaactgg
    12361 caatttttcg acctgaatta catttttcca taaaaaatga gacctttcta gtctcattta
    12421 gtcattctta gtattttcta aatcgttgat agcgttcttc cagcaactct tctagcggtt
    12481 tttgtgaaag tctagccagc tccgtttgga gttctttttt gacactctta atcagttctt
    12541 tactagaaag tcctatttca gaaatcacct tatccaccac gtccatttct aacagttcat
    12601 gcgaagtgat tttcatcagt tctgctgctt ccatagcgcg agtaccgtcc ttccataaaa
    12661 tggaagcaaa gccttctgga ctgagaatgg catagataga attttccagc atccagacac
    12721 ggtccgcgac agctagagcc agagccccgc ctgaaccacc ttcaccgata ataatggcga
    12781 taataggaac tttcaggtca ctcatttcca tgagattgcg agcgatagct tccccttgac
    12841 cacgttcttc cgctccgaca ccaggataag cacctgctgt attgataaag gtcacaactg
    12901 gacggccaaa tttctcagcc tgtttcatca accgcagtgc ctttcggtag ccttctggat
    12961 gtggttggcc aaaattccgt ttgaggttgt cttgcaaact cttgcctttt tggataccaa
    13021 ccactgttac agcttgatct ccaagccaac caataccacc aacaactgca ccatcatcac
    13081 gaaaagaacg gtcaccatgt aattggataa attcatcaaa aatgcctgtc gcaaagtcca
    13141 aggttgtcaa gcgactctgc tcacgcgctt ctctgactat ttttgcaata ttcatctagg
    13201 actccctcca tgcaatctga ctaggctagc aatcgtatct ggtaagtctc ttcttttgac
    13261 aatagcatcc acaaagccat gttctaatag gaattctgcc ttttggaaat cctcaggcaa
    13321 gctttcacga accgtatttt caatcacacg acgcccagca aaaccaacca agctctgtgg
    13381 ttcagccaga atgatatcgc cttccatagc gaaagaagct gtcacaccac cagtcgttgg
    13441 atctgtcaaa atggtcaggt aaaagagacc agcatttgaa tggcgtttaa ccgccgcaga
    13501 gatcttagcc atctgcatga gactcatgat tccttcctgc atacgggctc caccagaggc
    13561 tgtgaatagg acaactggca atttttcgac agtcgcatac tcaaacaaac gagtgatttt
    13621 ttcacctaca accgtaccca tagaagccat gataaagtta gaatccataa tcccaagagc
    13681 cacagtctga cctttaataa gagcagttcc tgtcacaacg gcttcatgca gacctgtttt
    13741 ttcacgcata gatgccagtt tcttttggta accagggaaa tgcaagggat ccttgctttc
    13801 aatccctgta aacaattctt tgaaggttcc catatcaatc gtcaaagcca agcgttcttg
    13861 ggcagaaata cgaaaggtat agctacagtg cggacagata cgttcacttc ccagatcctt
    13921 ctgatagatg gtatgcttac agcctggaca ctgggaaaat aattcatctg gaacctctgg
    13981 cttagcttga ggtttttccc taaccgaacg attgggattg attcgaatat acttatcttt
    14041 tttactaaat agagccattg attccccttt tcggtttaaa ctcttaaagt cattttattc
    14101 tttttcttga tatttaggta agaaggtttc catcaagaag gaagtatcat aatccccagc
    14161 aatgacattg cgatctgaaa tgaggtcaag ctggaaatct gcattggtct gcactccttc
    14221 aatctctaat tcatagaggg cacgttgcat tttcatcaag gcgtcaaaac gattttcgcc
    14281 gtgtactatg attttggcaa tcatactatc ataataaggc ggaatggtat aacctggata
    14341 aactgctgaa tccacgcgca agccaactcc accacttggc agatagagat tagtaatctt
    14401 acctggactt ggagcaaagt taaaggctgg gttttctgca ttgatacgac actcgatggc
    14461 atgaccgcgt aggacaatat cttcttgctt aacagacaaa ggctgacctg ccgcaatgca
    14521 aatctgttcc ttaacgatat caacacctga aacaaactct gttactggat gttctacctg
    14581 aacacgagta ttcatctcca tgaaatagaa attgctactt gcttcatcaa gaagaaattc
    14641 aatggttcct gcattctcat agccaacaaa ctctgccgct cgaacagcag cagcacctat
    14701 ttcatgacgc agcgtttttc cgattgcaat cgagggactt tcttccaaaa ccttttggtt
    14761 attcctttga agagaacaat cccgttcacc caagtgaatc acatgtccat gctcatcacc
    14821 taggatttga acctcaatgt gccgagctgg atagataacc cgttctatgt acatggcacc
    14881 attgccataa ttggccttgg cctcactaga ggcagtttca aaggcagaaa cgaggtcatc
    14941 tggtttttta accttacgaa tccctttacc acctccacct gctgaagcct tgagcataac
    15001 aggatagcca attttttcag caacaatcaa agcttcttca gagttatgca cttctccatc
    15061 tgaacctggt ataacaggca cacctgcttt aatcatctga gcacgcgcat tgatcttatc
    15121 ccccatcata tccataacat gaccagatgg accgataaac ttgataccta cttcttcaca
    15181 catggtcgca aatttggaat tttcactgag aaatccaaaa ccagggtgaa tagcttctgc
    15241 ctcagtcaag actgcagctg atagaactgc attaatattg agataagact ctgttgcctt
    15301 gccaggacca atacaaactg cttcatctgc caaaagcgta tgaagagctt ccttatcagc
    15361 agttgaataa accgctaccg tcgcaatccc caattcacgt gccgcacgga taatacgaac
    15421 cgcaatttca ccacgattgg caattaaaat ttttcgaaac atggagaacc tccttagttc
    15481 ccaattgcaa aagtaagggt accactggct gcaagcttgc catccacttc agcctttgct
    15541 tcaaccacag ctatggtgcc acgacgtttt acaaaagtcg ctgtcataac caattggtcg
    15601 cctggtacaa cttgcttctt gaacttaacc ttgtccatac cagcgtaaaa gaccagtttt
    15661 cctttatttt caggttttga taactccaac acaccggcag tttgcgccaa ggcttccata
    15721 atcagaacac ctggcataac tgggtattga ggaaagtggc cgttaaagaa aggttcgtta
    15781 atggtcacat ttttgatagc aacaatggta tcctcgctca cttccaagac acggtccact
    15841 agaagcatag gataacggtg gggaagagct tctttgattc cttgaatatc gatcatttga
    15901 tacgtaccaa tcctttacca aactcaacca tttcttcgtt agagacgaga atttccgtta
    15961 ccacaccatc cttaggagct gggatttcat tcatgacttt catggcttcg ataattacca
    16021 atgtttgacc ttttttgaca ctatcaccaa ctgtaacgaa ggcaggttta tctggtccag
    16081 cagccaagta aaccactcca acaagtggac tctctacaag atttccctca gtagccacac
    16141 ttgcttcagc tggagctgga acttcttctg ctacagtctc tgctggagca gatgtaggag
    16201 ctactggact cggtgttgct agaacgggtg ctggagcgac ttgagttgca acttcaggca
    16261 caggtcttgc ttcattcttg ctaaactgca actcatccgt cccattttta taagaaaatt
    16321 ctctcaaact tgactggtca aattgagtca tcaagtcttt aatatcgttt aaattcatac
    16381 ttatctattc tcccaacgtt tgaaagcaag aactgcattg tggcctccaa aaccaaaagt
    16441 atttgaaata gcgtatggaa tttctttctc caagccttgt ccataaacga cattagcttc
    16501 gatataatct gatacttcac ttgtcccagc tgtcattggt acaaagttat gacgcatagc
    16561 ttcgatggtg acgatagctt ctactgcacc cgcagccccc agcaaatgtc ctgtaaaaga
    16621 cttggttgat gatacaggta cttccttacc aagaacagct acgatagcac cactttctcc
    16681 tttttcattg gcaggagttg acgttccgtg agcattgaca taggctactt gctctggaga
    16741 aatctcagct tcttccaagg ctagtttgat ggccttgata gctccctgac cttctggatg
    16801 tggagaagtc atgtggtagg catcacaagt atttccgtaa ccaaccactt cagccaggat
    16861 agtagctcca cgtttttcag cgtgttcaag actttctaga accaacatcc ctgaaccttc
    16921 acccataaca aacccattgc gatccttatc aaatgggatc gaagcacgag ttggatcctc
    16981 tgtagtagag agagctgtta aggcttggaa accagcgatg gcaaaaggtg tgatagaagc
    17041 ttctgttcct cccaccaaca tcacatcttg gaaaccaaac ttaatggagc ggaaggcatc
    17101 cccaatcgca tcatttgatg aagagcaggc agtattgata gatttacaaa caccgtttgc
    17161 accaaaacgc atggctacat tcccagaagc catatttggt aaagcttttg gaagagtcat
    17221 tggtttgaca cgtttgggtc ctttttcatg aaggcgaagt acctgatctt caatttcctt
    17281 gattccacca ataccagatg caacgataac accaaaacga tccctattaa gagcctctac
    17341 atcaagattg gcatgattta cagcctcttg ggctgcatac aaggcatata aagaatagtt
    17401 atcaaaacgg ttggtatctt tttttacaaa gtatttatcg aacggaaaat cttggatttc
    17461 tgccgcatta tgcacatcaa agtcactatg atcaaatttt gtaatgccac caatgccgat
    17521 tttcccagtt gctaaactat tccaaaattc ttctggtgta tttccgattg gagatgttac
    17581 tccataacct gttaccacta ctcgatttag tttcattctt ttcacctcta gctttcgcta
    17641 catacttaag ccaccatcaa tggcaatcac ttgaccagtt agataatctt ggcctgctaa
    17701 aaatactgtc aaatctgcaa cctgctctgc ctgcccaaat tctttcatcg gaatctgagc
    17761 tagtgtagct tccttaatct tatctgataa gatagctgtc atatcagact caatcattcc
    17821 tggagcaatc acattgactc gtatattccg actagcgacc tcgcgtgcca cagacttggt
    17881 aaagccaatc aagccagcct tagaagcagc atagttagct tgaccaatat tccccatcaa
    17941 accaacaaca ctagacatat taatgatagc accttctctg gctttcatca tcggtttcaa
    18001 gactgattgt gtcatattaa aggcaccagt cagattgacc ttgagcactt tttcaaaatc
    18061 tgcttctgtc atcttgagca taagagtatc ttgggtaatc cctgcattgt tgaccaaaac
    18121 atctactgaa cccagttctg caatagcttg atcaatcata cgcttagcgt ctgcaaaatc
    18181 tgatacatct cctgaaatgg gaaccacctt gataccatag tttgaaaact cagcgagcaa
    18241 ttcttctgag attgccccac gactgtttaa gacaatgttg gctcctgctt gagcaaactt
    18301 gtgggcgatg gcaagaccaa ttccacgact cgaacctgta ataaagatat ttttatgttc
    18361 tagtttcatt tttttccttt caaaacttct acttatttta gtctattttt ctaaaagtgc
    18421 tactaaactc gcttgatctt ccacatgagc taagtgagca gtttgatcaa tttttttaac
    18481 aaagcctgac aagactttcc ccggtccaat ctctataaag ttgcttatgc ctgcttcttg
    18541 catgacccca atactttcat agaaacgaac gggttccttg acctgacgcg tcaagagctg
    18601 agcaatgtcc tctttttgca tcacagcagc ttctgtattg ccgactaggg gacaagtaaa
    18661 atctgaaaaa cttacctgag ctagagtttc agctagtttc tggctagcag gctcaaggag
    18721 agcggtgtga aagggacctg acaccttaag aggaatcaag cgtttggcac ctgcttcttg
    18781 caaaagttca accgctcgat caactgcaac cacttctcca gcaatgacga tttgtgcagg
    18841 tgtgttatag ttggctggag taaccactcc aagttcagaa gctttttgac aggcttcttc
    18901 aatgacctct actggcgtat tgagaactgc taccatcttg ccagagtcag caggagccgc
    18961 ttcttccata taggctccac gcttagctac caaggcaacc gcatcttcaa aatccaaggc
    19021 gccgcttgcc accaaggcag agtattctcc aagagacaaa ccagcaacca tatcaggctg
    19081 atagcccttt tcttgcaata aacggtagat agcaaccgaa gtcgctagaa tggctggttg
    19141 cgtatagcgg gtctgattga gtttgtcttc ttccgtatcg atgagataac gcaaatcata
    19201 acctagtacc tggctcgctc gatcaatcgt ttctttaaca atcggatact gatcatagaa
    19261 atcccgtccc atccctagat actgggcacc ttgaccagca aataaaaagg ctgttttagt
    19321 catttcttac aactcctgtc cagcgagagg cttcttcttg aattttctta gcggctccgt
    19381 aatacaaatc ttttaggatt tcttcagctg tttcttcttt agaaacaagc cctgcgattt
    19441 gacctgccat aacagagcca ccatccacat caccgtgaac aactgctttg gctagagcac
    19501 ctgctcccat ttgttcaaag atttctaaat caggatcttc ttgcttaaag gcatcttttt
    19561 cagccagttc aaaatctcta gtcaactgat ttttaatagc acgaacagca tgaccaaagt
    19621 gctgagctga aatcgtagta tcaatatccc ttgcttttaa aattttctcc ttgtagtttg
    19681 gatgggcatt cgactctttt gcaactacaa accgtgtccc cacctgtaca gcctctgcac
    19741 ctagcataaa gccagccgca gcaccttcac catccgcaat tcctcctgca gcaataacag
    19801 gaatagatac agctgtggct acctgtcgca ccaaagtcat ggttgttaat ttaccgatat
    19861 gccccccagc ttccattcct tctgcaataa cagcgtctgc accgattttt tccatgcgtt
    19921 tagctaaagc aacactagga acgacaggaa taacgattat cccagcttca tggaaacgtt
    19981 ccatatactt gcttggattt cctgctcctg ttgtgacaac tttaacacct tcttcaataa
    20041 cgagatccac gatatcttcc acaaagggag ataagagcat gatgttgacc ccaaagggtt
    20101 tatcagtcaa tgatttgatt ttatcaatat tggccttgac aacttctttc ggggcatttc
    20161 ccccaccgat aattcctaat cctccagcct tggaaacagc ccctgccaaa tcaccatcag
    20221 caacccaggc catccctcct tggaaaatag gatagtcaat cttcaataat tctgtaatac
    20281 gcgttttcat agtgcctcca accttccttg cttacgtaat agttcgattt caccataatt
    20341 tgacagtcaa actattacct aaacaagagg gagtgggttt ctccctactc cttctactta
    20401 atattctgct tattttgctt gctcttcaac gtaagcaacc aagtcaccaa ctgttttcaa
    20461 gtcattttct gcttcgattt ggatatcaaa agcatcttcg atttctgaga ttacttggaa
    20521 caagtccaat gaatctgcgt ccaaatcatc aaaagttgat tcaagtgtta cttctgatgc
    20581 gtcttttcca agttcttcaa cgataatttc ttgtactttt tcaaatactg ccatgatagg
    20641 actcctttaa aataaatagt ttttttataa caatgtgttc accacatgat tacctaaatt
    20701 gtaagaatga gcgtgcccca ggtcaaacct ccaccgaagc ctgatagaag aacagtctgg
    20761 ctaccatcta aagggatgag accttgttct acacactctg aaagtaaaat cgggatactg
    20821 gctgcactgg tattgccata ttccatcata ttggctggaa gtttggctcg gtcaacacca
    20881 atttttctag ccatcttatc caaaatacgg tcattggctt gatgaagtag cagataatcc
    20941 aagtctgtca cctctatagg agattcatca atagtctgct tgatagactt ggctacatct
    21001 cgaatggcaa aatcaaagac tgtgcgtcca tccatcttca aaaatgaatc tgcactttct
    21061 tgatctgaaa atggagaatg caaacctgaa tgcccataag ttaaacactc gctgcgactt
    21121 ccatcgctat tgagactctc agctaagaaa tgctcttgct cgctagcttc taacaagaca
    21181 ccaccagcac catctccaaa caacacagct gttgatcgat ccgaccaatc gactgcctta
    21241 gagagggttt cactaccaat caccaagcct ttttgaaagc gaccagaagc gataaacttt
    21301 tcagcagttg aaagagcaaa tacaaatcca ctgcaagccg cggttaagtc aaaagcaaag
    21361 gctttattag caccaatatt agcttgaaca cgagcagctg tagagggcat catcgaatct
    21421 ggagtaatgg tagctaggat gataaaatcc agttcttttc ctgttattcc agcttttgcc
    21481 atcagtttct tagcaacctc tgtagccaaa tcactggtag attctgttct tgaaatatgc
    21541 ctttgtcgta ttcccgttcg acttgaaatc cactcatcat tggtatccat aatctgagcc
    21601 aagtcgtgat ttgtaaccac ttgctctggc acataatgag caacctgact tatttttgca
    21661 aaagccatta tttcaaatcc tccaaaaatt ggtaaagatt agtcaagcct ttacccatga
    21721 cagcaatttc ttcctcgctc atgccatcaa taattttttc taccatggcc ttgtggaagc
    21781 gtttatgcag tctatgaatc aagcgaccct tctttgtcaa atgcagatgc accacacgac
    21841 gatcctgttc tgaccgaact cgctcaatgt agcccttacg ctctaaattg ttcaaacttg
    21901 tcgtaacagt tccaagagtt accatcaact cttttgacac ttgacttgga gtcacatctg
    21961 gagccttacc gatgacatca atcgtatgca tttctttgat ggagatatcc ttaaaacgac
    22021 tacctctcaa gttcacttcc tcaattacaa ggacattgtt aaatatagat gttaaatatt
    22081 cattgattcg ttggtagtcc atttttcata tccctccttc ttcaaaaaac ttttacaatc
    22141 aaaacatttg acagaaagaa ttatatcaaa attcaaagaa tgatgcaagt attttttatt
    22201 ttcctgtaaa tttaggtctt cttctctccg aatgagctcg cactccttct ttgaaatcct
    22261 ctgtttgagc taaggatttc tgtaggttca gttctaaagt agcgtaaccc tgccagtctt
    22321 taaattggct ctcccaaacc aacttcttaa tggcagcata ggaattactt gaagcacgtc
    22381 ttaatttttt aagaagctgt tctctcgtct tttcaagttt ttcagcttca gaaacgcggt
    22441 aaaccaaccc ccattctagg gctttttctg ccgttaaagc ctctcctgtc atagctaatt
    22501 gagcagcacg cgtcacaccg atactgcggc tcaagagatg aattccccct gcatctggag
    22561 ccaaaccaac accaacaaag gcttggataa acttagcctt atccgtcgcc aaacagaaat
    22621 ctgccgcaac agccatattc gctgcggcac ctgcaacagc accgtcaact tccattaaaa
    22681 caggtttggc tatttgcttg attttataag aaatcgtatt gaccaactct gcgatttttg
    22741 tcaatgatgg aatatcatcc tcatccactg cccgcttcat ctctaccaaa tctcccccaa
    22801 ctgagaagac ctttccattg gcattgatta agataaaatg cacagctgga ttttcttctg
    22861 ccaaagtcag agcttctaaa atctcctcac acatgggaat atgaaaacca tttgcgacct
    22921 caggacggtt caaggtaagg attgccaagt cctcttcaag ctgataaata atgtgttcca
    22981 tcagggctcc tttttatttt ataagcagtt tatactcttc gaaaatctct tcaaaccgcg
    23041 tcagcttcca tctgtaacct caaaacagta ttttgagctg acttcgtcag tcttatttac
    23101 aacctcaaag cagtgctttg agcagtctgc ggctagcttc ctagtttgct ctttgatttt
    23161 cattgagtgt taaattattt cactgtcaaa gtatatcttt tttaggagca gaaagcaaga
    23221 aaaaatcgac tgaaagtgtc tcagccgata agaaaggctc gctttaggct agaaagcatc
    23281 ttattttctt cattgaaaaa agcctttctt tctgctataa tcgtataaaa tacttacttt
    23341 aggagttctt atgaaagttg ttaaatttgg aggtagttct cttgcctctg ctagtcaatt
    23401 agaaaaagtt ttaaacatcg tcaaaagcga ttcagagcgt cgttttgtag tcgtttctgc
    23461 gcctggtaaa cgcaatgctg aagatactaa ggttacggat gccctgatta aatactaccg
    23521 cgactatgtt gcgggtaacg atattagcaa gagccaaagc tggattatcg accgctatgc
    23581 tgctatggtt agtgaattgg gactaaaacc agctgtgcta gaaaaaattt ctaaaagcat
    23641 tcacgccttg gccactcttc ctattgaaga aaatgaattt ctctacgata ctttcctagc
    23701 agccggtgaa aataacaatg ccaaattgat tgctgcctac tttaaccaaa atggtatcga
    23761 tgcacgctat atgcacccta gagaagctgg gattgtggtc acaagtgaac ctggtcacgc
    23821 tcgcatcatt ccatcaagtt atgacaagat tgaagaattg acaaacacca atgaagtcct
    23881 tgtcattcct ggtttctttg gtgtcactaa ggaaaatcaa atctgtactt tctcacgtgg
    23941 aggatctgat attacaggtt ctatcattgc tgctggtgtc aaagctgacc tctatgaaaa
    24001 ctttacggac gttgatggta tctttgcagc ccaccctggt attatccacc aaccacactc
    24061 gattcctgag ttgacctacc gtgaaatgcg cgagttggcc tatgcaggct tctcagtcct
    24121 tcatgacgag gctcttcttc ctgcctaccg tggaaaaatt cctctggtta tcaagaatac
    24181 caacaaccct gaccatccag gtactcgtat cgttctaaaa cacagtaatg atgaatttcc
    24241 agttgtggga attgctggtg actcaggctt tgtcagcatt aatatgtcga aatacctcat
    24301 gaaccgtgag attggatttg gccgcaaggt tctgcaaatc ctggaagaac ttaacatcgg
    24361 ttgggaacat atgccaacag gtatcgacga tctttctatc attctccgtt ctcgccaact
    24421 aactcccatc aaggaagaag aaatcctgcg tcagttggtt caaaaggcta aagtagatca
    24481 tgcagaaatc gaacacgacc tttctatcat tatgattgtt ggtgaaaaaa tgaagagcca
    24541 tatcggagtg actgctactg cgacacgcgc tctatctgaa aacaaaatca acatccagat
    24601 gatgtctcaa ggttctagtg aagtttctat tatgtttgtt gtcaataaag accaagagaa
    24661 agcagcaatt aaagccctct actatgcctt ttttggagaa agtaaggaag actaagcatg
    24721 gctcaatcac ttaacaaaac agtactcctc agtacgacag gcacttccta cctctctatc
    24781 gctgggaaag ttgggaaatt ccttgtcgga gatcaggctt tggaatttta cccagatgtc
    24841 aatgtcgaac aatttatcca gattccttgg agccatatca atcagattgg agccaatgtc
    24901 actggacgca aagtcagccg ccacttcgaa gtctttacag acaaaggaaa attcctcttt
    24961 gcttcaaaag actcaggtgc cattctcaaa attgcacgcg aaaaactagg caatgacaag
    25021 gtcgtcaaac ttccgaccct gattcagaca attagccaaa aatttaaaaa tctatttgca
    25081 aaaaagtaga aactttagta taatcatagc aacggataag taggttatct tcttctttca
    25141 gaaagtctgc gggtactgcg agcagatagg ggggataggt gaaattctac cgttagtaac
    25201 aattacatac acaatcaagt gcacacctgt gaagttggat ggaaccgtgg ccctgccact
    25261 ccaacgtttt gtcaggcgtg cttttttcat aaaggagttc ttatgttaga tatcaaacgt
    25321 attcgtacag attttgaagc tgtcgcagaa aaattagcta cacgtggtgt agatgctgct
    25381 gtcttgaatg aaatgaaaga aatcgatgct aaacgtcgta acatcttggt caaggttgaa
    25441 actctcaaag cagaacgtaa cacagtttct gctgagattg cccaagctaa gcgcaacaag
    25501 gaaaatacag atgacaagat tgctgccatg caaaatctat ctgctgaggt taaagccttg
    25561 gatgctgaat tggcagaaat cgatgctaaa ttgacagaat ttacaacgac tcttccaaat
    25621 atcccagctg acagcgttcc tgttgggact gacgaagacg acaatgtgga agttcgccgt
    25681 tggggtactc cacgcgagtt tgacttcgaa cctaaagctc actgggatct cggtgaagac
    25741 cttggtatcc ttgactggga acgcggtggt aaggtaacag gcgctcgctt cctcttctat
    25801 aaaggcctcg gtgctcgttt ggaacgtgct atctacaact ttatgttgga tgaacatgga
    25861 aaagaaggct atactgaagt catcacacct tacatagtca accatgattc tatgtttggt
    25921 actggtcagt atccaaaatt taaggaagat acttttgaac tcagcgatac caactttgtc
    25981 ttgattccaa ctgctgaagt tcctctgaca aactactacc gtgatgaaat cttagacggc
    26041 aaagatcttc caatctactt cactgccatg agtccgtcat tccgttctga ggctggttct
    26101 gccggtcgtg atacgcgtgg cttgatccgt ttgcaccaat tccacaaggt tgaaatggtc
    26161 aaatttgcca aaccagaaga atcttacgaa gaattggaaa aaatgacagc caacgctgaa
    26221 aacattcttc aaaaactcaa ccttccatac cgtgtcgttg ctctctctac tggagatatg
    26281 ggcttctcag ctgcgaagac ttacgacttg gaagtgtgga ttccagcaca aaacaattac
    26341 cgtgaaatct caagctgttc aaacacagaa gatttccaag cccgtcgtgc ccaaatccgt
    26401 taccgtgatg aagcagatgg caaggtgaaa ctccttcata ccttgaacgg ttctggactt
    26461 gcagttggac gtacagtggc tgcaattctt gaaaattacc aaaatgaaga tggttctgtg
    26521 accatcccag aagcacttcg tccatacatg ggtggagctg aagtcatcaa accataaaaa
    26581 ataaggttta gctatttcta gctagacctt ttttcgtaac caaatcagat aagcacctag
    26641 tacaaagaat aaaatagtta ggcatataat ggtttcagcc aataccaggt aatccagaaa
    26701 tggaagtttc aaaattccct gagccatctt gagcgaggtc gctgtgataa tggttgggaa
    26761 ggtgagggct gagaaggctg gttgaaaacc ttgttttaaa atgttgggca gacgagttaa
    26821 aacaaagaaa aagaaggatt gagaagccaa aatcatgaca atcaagaccc aagtcggcag
    26881 gctggttcct cctactcgaa ctagagaagc caagagtaga gagaaaggag cacagtagat
    26941 tccttcttgt ccaagcaagg ctagtgggag tggatgtttc tttaaatcgc tataaataag
    27001 gggatagaga tagaaggtca agagaaaacc aaaactcaag gtcgcatagg caatttcgat
    27061 aatacctacc agaggatagg tcaaggcagc cactgctatc cccacataga gaaccgtcca
    27121 gcttggagtg gcatgaaccc tccgccctgg acaagcaaac ttgatggtaa aaccagcaat
    27181 caaggtcaaa tccaagagaa atgaaaacca ccaaatccct tgtgctacca aaggaagata
    27241 agagaatacg cgaaagacat aggtcgataa aatcatccca gccataggaa aggttgccat
    27301 tcctgacaaa agagggggct tggtcaattc ttgcttggtt tctttccaat taaagagatg
    27361 cagaattaga aagtaaatcc ataaaaccaa accagtcaga ctaaaaagat gggatagaac
    27421 cggcaacgta tctaaaataa gatttccagc tcctgccaaa cctagcaaac aacctgaaaa
    27481 tactaagggg agttttttca tcctaacctc caataatcat gttagtttca gtataacata
    27541 aaagcgctta aatgaggatt taaaaaaacg aagtccgatt atttcagact tcattttact
    27601 cagatatgaa ttaggcataa ggttgcaatt ctggattaat tggtgtatta gctaagttgt
    27661 tggcatagtt acagaggatt gctaggctga caccaaaaac cacatccaag gcattttgtt
    27721 gagtgtagcc agcttctaaa aactcagaca aggcttcatc tcctacacga cccttggtat
    27781 tgataactgc caaggtaaac ttagctaggg tatccaattt aggatctgtt tcaattggag
    27841 tacgattgcg aagagcttga atcaagtcat cattcatctg gatttgtttg atggaaaagg
    27901 ctgtgtgacc tgcgacacag aaggcacaac cattggtcac ggctgccgtg atttgcacca
    27961 cttcacgctc aacgggtgtc aggctgttgc gacggtggat agatgagaca atttggtagg
    28021 cttctaaaac agtcggggca ttggccaaga gaccgattag gttgggaata tagccattgt
    28081 tgtctttttc tactgtttca agaatttctt tcacttctgc tggtgctgac tctactgtat
    28141 ggatagtaaa tgttgtcata agatacctct tttcttatta ttgacactaa tattattgga
    28201 aaatcttata aaatcctgat tcctaagttt atctaagata aagctttatt ctctcataag
    28261 attttcgttg ttatattagt ttatcacact tccaatcact tgcataatat atattatata
    28321 tcaggctgat aaaaattatt tataggcaaa aaaatcacac gagctgtgtg attccattat
    28381 ttgttaaaat actttttagt ttcagcaata acgactggcg acaagaccaa gagggcaatc
    28441 aagtttggca gagccatcaa ggcgttaacg atatctgcga taatccagac catatccaac
    28501 tcgataaatc ctcctaacaa gaccatgagc acaaaaaaca cacggtagag ccagataaag
    28561 cgagccccaa agaggaactc aaaacagcgt tctccgtaat agttccaacc tagaatcgtt
    28621 gtaaaggcaa aaagtacaag gaagatggtc aagagggcag gcccaaagtg tgaaaagact
    28681 gttgagaaag ctgactgagt caaggcaacc ccattcaagt caccactcca aactccagtt
    28741 accaagatgg tcaaaccagt tagagtacaa atgatgaggg tatcaataaa ggttcctgtc
    28801 atggaaatca aaccttgctc tactggttca tttgtcttgg cagctgcaat aggagcagaa
    28861 cccagaccag attcgtttga gaacacacca cgcgccacac cattttgaat agccatccga
    28921 acgctagcac cagcaaatcc acctaccgca gcaaggggac taaaagctga ggtaaagact
    28981 aaagcgattg tgccagggat ttttccgata ttaaagaaaa taactgtaag agttcctaag
    29041 atataaatga gggccataaa aggaacaaca gtagttgaaa ccttagaaat agacttgagt
    29101 ccaccaaaga ctgcaatcgc tacaaagaca gacaagacga gagctgtgat ggctggcgaa
    29161 atcgtcgttg tattttggat agattctgta atcgagttga cttgggtgaa ggttccgatt
    29221 cccaagagag caaccaatac tcctgctact gcaaacaaaa cagcaagtgg tcgccacttt
    29281 tctcccatcc ctagaaggat atagtgcatg ggacctcccg ctactgcacc atggtcgtcc
    29341 ttggtgcggt atttgatggc caagagtcct tccgcatact tggtagccat tccaaagaaa
    29401 gccgccatcc acatccaaaa tagagctcct ggtccaccaa ccttgatagc cgtcgcaact
    29461 cctatgatat ttcctgttcc aacagttgat gccaaggctg tacacagagc tgcaaaactg
    29521 gatacatcac catgtccctt atcctggata aaaataagct gaaaggcctt gggcagacgc
    29581 aaaacctgca agagtcctag ccgcatggtt aggtaaatcc ctgttccgac caataaaatc
    29641 aagaggggcg gtccccaagc aaaagcatcg attgatttaa gcaattctaa catttccttc
    29701 tcctatcgtt tcaaccccaa aagaaagagc acatgcaaga tacatgtact ctggaatgct
    29761 tagataaatg ctaaaaagcg gtctatccta gctctgtcct tttacctgag agtttgagca
    29821 gttgcctgcc ttgccccttc ggtgccttta cggtctctcc agagttccgt ccatttacag
    29881 tcatggaaaa tcaaacgatt ccccacttct attaaacttc attcggtgtt ggtatttaat
    29941 tgattctaat tttacaaaaa atgttggctt ttgtcaatgt gtttattagt aaaaattagt
    30001 tcaacagttt ttactttata aagtccagaa tactgctatc ctttaaaagt gacaatagtc
    30061 gcaccactgc ctccagcatt ttgtggggca tagccgaaac tcttgacatg tttgtttctt
    30121 tgcaagtatt tggtaactcc ttcacggatg actcctgttc cgataccatg gatgatatca
    30181 acttgagcca tattgttaag caaggcttgg tcgatgaagg tatctagctc attcatggct
    30241 tcttcatagc gcttgcctcg aagatccagt ctagcttgag gtcctcgccc agaagttcgt
    30301 ttcacaacat tgacctgttt cttcttgact ggtttttctt gctgggcttg aacaagatca
    30361 aactctttct cttccaaggt catcttaatc aagccaactt gggcttccca gcgaccgtcc
    30421 ttgagttgac tggtcaaggt accacgctga ccataactga gaaccacgat atcatctccc
    30481 acctttggag ctcgtttttt cttggccttt tgaaggacct tatttttaga caagtccact
    30541 ttttcaggag ccaatttttt caacttgacc ttggcttcaa tgatttcgtg gggcttgagt
    30601 tgggatttac tgtggagatt tttgagaatc tggtcacttt cacttaaggc catatccaca
    30661 atctcagcag cctgttcacg cgccttgtta agctcggttt ccttttcacg attaagctcg
    30721 ttgtagagtt tttttagcgc acggttcatc ttgagatttt cttgctccac ctcacggata
    30781 ttgtccaaac gtttgcggct ttccagcgtc tgctcttcta attgctcaat gatacgattg
    30841 acgtcattgt cctgatcgat ctgctgactg gcatctccta cgataacttc agataggcct
    30901 agacgtttgg caatttcaaa ggcattactt cggccaggaa caccctgcat aaagcgatag
    30961 gtcgggcgaa gagttgcagt atcaaactcc atactggcat tttgcacaaa ggctgtctca
    31021 ataccgtagg ccttgagttc tggatagtgg gtcgtcgcca tggtcttgat ttgacgcagg
    31081 cgaaggtcct ccagaatagc catggcaagg gctgctccct cttggggatc agtaccagcc
    31141 cccaactcat ccaaaagtaa gagtgaatgt tggttgacct tgccaagaat atccacgata
    31201 ttggtcatat ggctagagaa ggtagacaag ctctgctcaa tagactgctc atctccaata
    31261 tcagcaaaga tttcttcaaa aataccaaca cgacttccct tgtctgctaa aatcggcaat
    31321 cctgactggg ccatgacctg tgtcaagccc agagttttga gcatgatggt cttcccacct
    31381 gtattgggac ctgtaatgac aatagctgtt aaatcttgac caaaatagac atcatttgcg
    31441 acggcatttt tgaccaaagg atggcagaca tggagcagtt gaatctcttg attttctgac
    31501 agctgaggca cgactgcttg tctttcttgg ataaatcgaa ccttggcacg aatcaagtcc
    31561 agatgaccga taatccaagc gtcattagca atctcagccg catgagggcg gacacgctca
    31621 gaaatttctt ggagaatgcg aagcatttca tagcgctcat ctgctcgcag actagcaatt
    31681 tcttcgctca gtttgactac ctcacgtggt tcgatataga cggtgtttcc actagcagaa
    31741 atatcatgaa cgacacctgc aatcttattg cggtaggtgt ttttgactgg taaaacctga
    31801 cggccatttc tgctagcaac aattccttcc gtcaacatct gcgctttttg cttgagcaag
    31861 tcttgtaaaa catcgcgtac ctgactctcg ctatcatgta tttttcgacg gattcgcgcc
    31921 aattcttcac tggcaaaatt ttcaatgaaa cccgcatcat taaaggcctg aagatttcct
    31981 tgtaattgcg gaaaatcatg taatttctca aaccaaaggg ctaattcttc caagctgaca
    32041 ttttccagat tggcgtaaaa actttgaagt tctcggctgg taagaagcac gcgtttcaag
    32101 agtaggaact cctcgatatt gagatccgct cccatctcca acctcttgca gactcctgca
    32161 atttccttag ttgagagaat agtaaaatgc ggttgctcga cgaaaagagc ctgcatttct
    32221 ttcatctcag caaaagcctg tttgatttta tctgctttgg cagtcggagc cagctgtctc
    32281 aattgctcca agccctgctc ggtcaacaaa tgaggctcaa acaaggcctt gaccttatcg
    32341 agctctaatg tttctaatat tttcttattc atctttattt ccttgtcttt gaatgtctag
    32401 gtgtggtagc tttttacatt ctgatagatt cgagtcaaat ctgtaaacaa agggctagga
    32461 aaactcctgc cctttttatc cgattaaatt tgtcacccag atttgtttga gccaactggt
    32521 tgttatcggt atactctgga tgatgtgttt tgcgacgata ctcttttcaa gaggattttg
    32581 tataactgcc atggggatgg tcgccaagat tgtcaaggcc atttgcaaga caaataaggt
    32641 caccaacatg gacaagatac ctgctgaaac ttggaacaac ttaccaccca gttttttgct
    32701 aggaatcaag tgtaagagaa gaccaagcaa acgaccaatg ctatagacaa tcccaaatac
    32761 aagcaagtag ccgatacctg cataaaagac cttatccagc tgaaagagtt gatccgatgg
    32821 gaaaaagaaa gtcccctgac cttcctgcga atttgcataa gggagcaata aatggaattg
    32881 ctctccaagc cccttataaa actggccagc cataaaagcc gatgccatgg ctgaaatcag
    32941 gtaataaacc tgtaagagca ggcctctccg atagccgata taaaatcccc aaaccaagac
    33001 caatagaaga aggaatgaaa tcataaggaa tcctcaatct tgctctgttc ttgcttacaa
    33061 gtcacaagct tgtgacggag ttcttctagc tcttgctcct tatcgtcaaa ttcaatctca
    33121 cggctgagct gagttgataa acagttgact gccaacaaaa gagcgattgt ttcatcatct
    33181 gcgctaggca tttgttcttt aattgcttgg tatttttctg tcgcaacctt agcgatttcc
    33241 tccataaaaa ggttatcatg ttcgcttgtc aaggttaacg attttttccc gaatgtaaat
    33301 ttgaatcgat ttagatttgc cataaaattc acctcacgat attataccaa aattcgctaa
    33361 ttttgtcagt ttttacaaat tttactgctt ttgtggtaca atagaaacta tggcaagtat
    33421 cacactcaca ccaagcgaaa aggatattca ggcttttctt gaacactatc aaaccagtct
    33481 ggctcctagc aagaatccct atatccgcta ctttttgaaa ctacctcaag caacggtttc
    33541 tatctatact tctggaaaaa tcttgcttca gggtgaaggg gctgaaaaat acgccagttt
    33601 ctttggctat caagctgtag agcaaaccag cggacaaaat cttcctttaa ttgggacaga
    33661 tgaggtggga aatggttcct actttggtgg gcttgcagtt gtggctgcct ttgtcacacc
    33721 tgaccagcac gactttttac gaaaactcgg tgtgggggat tctaagactc tgaccgacca
    33781 aaagatccgt cagattgctc ctattctcaa ggaaaaaatc cagcaccagg cactccttct
    33841 ctcacccagc aagtacaacg aggtcatcgg agaccgctac aatgctgttt cggttaaggt
    33901 tgccctccat aatcaggcta tctatctcct ccttcaaaaa ggtgttcagc ctgagaaaat
    33961 tgtgattgat gcctttacca gtgctaaaaa ttatgacaag tacttggcac aagaggccaa
    34021 tcgtttcagc aatcctatca gcttagaaga aaaggctgag ggcaaatact tggctgtcgc
    34081 agtttcttct gtcattgcgc gtgatctctt tctggaaaat cttgaaaatt tgggacgaga
    34141 actgggttat cagcttccaa gtggagctgg aacggcttct gacaaggtgg ctagccagat
    34201 tttgcaagcc tatggtatgc agggactcaa cttctgcgcc aaattgcact ttaaaaacac
    34261 tgaaaaagcg aaaaaacgct tagaaaggta agttatgaat tcacttaaaa atttcttaaa
    34321 agagtgggga ttgttcctcc taattctgtc attactagct ttaagtcgta tctttttttg
    34381 gagcaatgtt cgcgtagaag gacattccat ggatccgacc ctagcggatg gcgaaattct
    34441 cttcgttgtt aagctcctcc ctattgaccg ttttgatatc gtggtggccc atgaggaaga
    34501 tggcaataag gacattgtca aacgtgtcat cggaatgcct ggcgatacca ttcgttacga
    34561 aaatgataaa ctttacatca atgacaaaga aacggacgag ccttatctag cagactatat
    34621 caaacgcttc aaggatgaca aactccaaag cacttactca ggcaagggct ttgaaggaaa
    34681 taaaggaact ttctttagaa gtatcgctca aaaagcccaa gccttcacag ttgatgtcaa
    34741 ctacaacacc aactttagct ttactgttcc agaaggagaa taccttctcc tcggagatga
    34801 ccgcttggtt tcgagcgaca gccgccacgt aggtaccttc aaagcaaaag atatcacagg
    34861 ggaagctaaa ttccgcttct ggccaatcac ccgtatcgga acattttaag agacctaaga
    34921 ggccgagaat cacaaatctc agcctcttct tctatcgtga gaagtgattg tttattgaca
    34981 aatactcaat gaaaatcaaa gaacaaacta ggaagctagc cgtaggctgc ttaaaacagt
    35041 ggtttgaggt tgtggataga actgacgaag tcagctcaaa atactgtttt gaggttgcag
    35101 atggaagctg acgtggtttg aagatatttt cgaagagtat aaaataaaaa caatcccaac
    35161 tctcacctat tcatgcaaag gaattttatg gaagtttatt tttcaggaac cattgaacgg
    35221 attatttttg aaaatcccag caatttttat cgcatcctcc tcctagaaat cgacgatacg
    35281 gacgcagagg attttgatga ttttgaaatc attgtcacag gaaccatggc tgatgtaatt
    35341 gagggcgaag actatacttt ttgggggcaa attgtccagc actccaagta tggagaacaa
    35401 ctgcaaatca gtcgttatga tcgcgcaaaa ccaactagta agggattggt caagtacttt
    35461 tcaagtagcc atttcaaggg gattggtctc aagacagctc agaaaatcgt agatacctat
    35521 ggcgaaaata ccattgatga aattttgcaa cacccagaaa agttagaagg catcgcagga
    35581 ctctctgcca aaaatcgcga ggctttcgtc tccactctcc gtctcaacta cggaacggag
    35641 atggttttgg ccaaactagc caactacggc attcccaaca aactagcctt tcagattcaa
    35701 gacttttaca aggaagaaac ccttgatgtg gttgaaaatt atccctacca gctggttgag
    35761 gatatcaagg gtttgggctt tacaattgct gaccaactag ctgaggaact aggcatcgaa
    35821 agtcaggctc ctgaacgctt ccgcgccggt ctagttcaca gtctttttca ggcctgtatg
    35881 gaaacaggag acacctatgt tgaagcacgg gatttgctgg aacaaaccct tactctcctt
    35941 gagtcttccc gtcccgtaga actagacccc agccaagttg cccaagagct ctcctacctg
    36001 atcgaagaag acaaggttca gcagattgat accaagatct ttgacaacag cctctttttc
    36061 gctgaggaag gtatccgcag tcacttgatt cgtatccttg aaaaaggaga acagaagaga
    36121 caagatttag aaactattca aaagcatatc actactgtcg agcaagaact ggggattgag
    36181 tatgataaca ttcaaaaaca agctatttgt gacgctatcc agaacaaggt ctttatcctg
    36241 acaggtgggc ctggtactgg taagacaact gttatcaatg gaatcatcgc tgtttatgcc
    36301 cttttagaag gacttgactt caggaagaaa agcaatctgc ccattcttct tgctgctcca
    36361 actggtcgag ctgctcgtcg catgaatgaa ttgacaggtt tgcctagcgc gaccatacat
    36421 cgccacttgg gaatgacagg tgacgatgat accagtcatc tggaagatta cctagatgct
    36481 gactttatca tcgtggatga attctctatg gtagatactt ggctgaccaa tcaactcttc
    36541 tccaatatct cttctaacag taagatcctc atcgtaggtg acagtgatca gctaccttct
    36601 gtcagtcctg gacaggttct agcggatctg cttcatattc ctttgattcc tcagactcgc
    36661 ttggaaaaaa tttatcgaca aagcaaagaa tcaaccatcg tcaccctagc tagtcagatt
    36721 cgacagggca tcttgccagc tgatttcacc caaaaaaaag ctgaccgttc ctactttgaa
    36781 attgctagtg gccatattcc tgccaccatt gaaaaaatct taggtgtcgc cctcagaaat
    36841 ggtattcctg cccgtgatat ccaagttctg gctcctatgt accgagggac ggcagggatt
    36901 gatgctatca atcagctcat gcaagacctg ctcaatcccc cacaaaaaga tcaactcagt
    36961 tttgaagctc ctcagtgcca ctatcgtaag agagacaagg tcattcattt ggttaacgat
    37021 gctgaaatca atgtctttaa tggggattta ggagctatca cagacctgat tcctggtaaa
    37081 tacaccgaat cgaaacaaga cgagattgtc attgattttg atggtaatga agtctcttac
    37141 ccccgtaacg aatggtacaa gattcgcttg gcctatgcca tgagtattca taagtctcag
    37201 ggaagtgagt tcccagttgt catcctaccg attactagtg ctagccgacg tatgctggag
    37261 cgaaatctca tctacacagc cattacacgt gccaaaagca aactcatctt actaggcgaa
    37321 ttacaagcct tcgactatgc tacccaacac atcggaactg cccgaaaaac ctatctgatt
    37381 gaacgcttca gtgatctact ggagaatgtt gaagaaaagc aacaagctgt ctctgaaaca
    37441 gtcacatcaa gtgcctctga acaatcctac atcctaaccg aagaaaactg ggacagcatt
    37501 ccagccatga ttgggattac agacacagac ctcaaagaga tttttggaaa atagtacatc
    37561 agaaaaccca ccaattcagg tgggttttct gtttattaag attattttac tgttgctgtg
    37621 cttgtgatca attcaacagc ttttttgata gtgatatcat gtttcaacat gtcagctgaa
    37681 agcaagtttt gaacttgtgc aacttccatg ttgtagtctg ctgccaattg ctcaacttct
    37741 ttttggattt cttcttctga agcatcaaat ccttcagctt tggcaactgc ttcgataaca
    37801 aggttagtct tagtacgtga ctcagcttct gcttggtatt ggttgtgaag gtcttcttga
    37861 gtagttccag tgatttggaa gtacatgtca gggttgatcc cttgacgttg caagttccca
    37921 aggaattcat ttactgaacg gtgaacttct tcatggatca tttcttctgg aagttctacg
    37981 atttcagcgt tttctacagc tgtatcaatt gctgcacctt caactgcatc tttgtaagct
    38041 tcttctttag cagcagccaa ttctttgcgg tatttttctt tcaagtcagc aagtgtttca
    38101 acttcttcat caatgtcttt tgcaagttca tcgtcaagag ctggaacttc tttagctttt
    38161 acttcgtgga tagttgtcac gaatttagct tctttacctg caaggtcttc tgcttggtag
    38221 tcttctggga atgttacgat aacatcaacg gtttcgccag ctgagtgacc taccaattgg
    38281 tcttcgaaac cagggatgaa ttgacctgaa ccaagtccaa gtgagaagtt ttcacctttt
    38341 ccaccgtcaa attcaacacc gtcgatagaa ccaacgaagt cgatcacaac agtgtcgccg
    38401 ttttcagcag cagcttcctt gataaccaat tcagccag
//
LOCUS       DBMVGT010000013        35999 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.013, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000013 DBMVGT010000000
VERSION     DBMVGT010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 35999)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 35999)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..35999
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.013"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..259)
                     /locus_tag="AC0DU4_000703"
     CDS             complement(<1..259)
                     /locus_tag="AC0DU4_000703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236702.1"
                     /translation="MNDEASKQLTDARFKRLVGVQRTTFEEILAVLKTAYQLKHAKGG
                     RKPKLSLEDLLMATLQYVREYRTYEQIAADFGIHESNLIRRS"
     gene            236..508
                     /locus_tag="AC0DU4_000704"
     CDS             236..508
                     /locus_tag="AC0DU4_000704"
                     /inference="COORDINATES: protein motif:HMM:NF036719.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide-binding domain-containing protein"
                     /protein_id="HIN4236703.1"
                     /translation="MFTCFIIHRTTIPYFVSQEVYWKVRNIEAEAIRRNCERGAIFSG
                     KIKYHEDSQFKGDHYVECYAVLDNTVIARDRITVPIDPLCGKDFIE"
     gene            702..2036
                     /gene="trmFO"
                     /locus_tag="AC0DU4_000705"
     CDS             702..2036
                     /gene="trmFO"
                     /locus_tag="AC0DU4_000705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate--tRNA-(uracil(54)-
                     C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO"
                     /protein_id="HIN4236704.1"
                     /translation="MSQSYINVIGAGLAGSEAAYQIAERGIPVKLYEMRGVKSTPQHK
                     TDNFAELVCSNSLRGDALTNAVGLLKEEMRRLGSVILESAEATRVPAGGALAVDRDGF
                     SQMVTEKVANHPLIEVVRDEITELPTDVITVIATGPLTSDALAEKIHALNDGAGFYFY
                     DAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNAPMTKQEFMDFHEALVNAEEAPLSSF
                     EKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQ
                     DNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLEQT
                     YRSKKQPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKEESEAIFPETTAIGSLAH
                     YITHADSKHFQPMNVNFGIIKELEGERIRDKKARYEKIAERALADLEEFLTV"
     gene            2120..2857
                     /gene="pyrH"
                     /locus_tag="AC0DU4_000706"
     CDS             2120..2857
                     /gene="pyrH"
                     /locus_tag="AC0DU4_000706"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000013002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0033862 - UMP kinase activity [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HIN4236705.1"
                     /translation="MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSL
                     GIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQ
                     TAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILM
                     AKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNM
                     NQPGNIKRVVFGENIGTTVSNNIEEKE"
     gene            2866..3423
                     /gene="frr"
                     /locus_tag="AC0DU4_000707"
     CDS             2866..3423
                     /gene="frr"
                     /locus_tag="AC0DU4_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008135 - translation factor activity, RNA
                     binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HIN4236706.1"
                     /translation="MANAIIEKAKERMTQSHQSLAREFGGIRAGRANASLLDRVHVEY
                     YGVETPLNQIASITIPEARVLLVTPFDKSSLKDIERALNASDIGITPANDGSVIRLVI
                     PALTEETRRDLAKEVKKVGENAKVAVRNIRRDAMDEAKKREKAKEITEDELKTLEKDI
                     QKVTDDAVKHIDDMTANKEKELLEV"
     gene            3483..4337
                     /gene="cvfB"
                     /locus_tag="AC0DU4_000708"
     CDS             3483..4337
                     /gene="cvfB"
                     /locus_tag="AC0DU4_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding virulence regulatory protein CvfB"
                     /protein_id="HIN4236707.1"
                     /translation="MNTNLASFIVGLIIDENDRFYFVQKDGQTYALAKEEGQHTVGDT
                     VKGFAYTDMKQKLRLTTLEVTATQDQFGWGRVTEVRKDLGVFVDTGLPDKEIVVSLDI
                     LPELKELWPKKGDQLYIRLEVDKKDRIWGLLAYQEDFQRLARPAYNNMQNQNWPAIVY
                     RLKLSGTFVYLPENNMLGFIHPSERYAEPRLGQVLDARVIGFREVDRTLNLSLKPRSF
                     EMLENDAQMILTYLESNGGFMTLNDKSSPDDIKATFGISKGQFKKALGGLMKAGKIKQ
                     DQFGTELI"
     gene            4346..4561
                     /locus_tag="AC0DU4_000709"
     CDS             4346..4561
                     /locus_tag="AC0DU4_000709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YozE family protein"
                     /protein_id="HIN4236708.1"
                     /translation="MRKSFYTWLMTERNPKSNSPKAILADLAFEESAFPKHTDDFDEV
                     SRFLEEHASFSFNLGDFDSIWQEYLEH"
     gene            4647..5615
                     /locus_tag="AC0DU4_000710"
     CDS             4647..5615
                     /locus_tag="AC0DU4_000710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HIN4236709.1"
                     /translation="MKEHSIDIQLSHPDDLFHLFGSNERHLRLMEEELDVVIHARTEI
                     VQVLGEESACEEARQVIQALMVLVNRGMTVGTPDVVTAISMVKNDEIDKFVALYEEEI
                     IKDNTGKPIRVKTLGQKLYVDSVKQHDVTFGIGPAGTGKTFLAVTLAVTALKRGQVKR
                     IILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYQILGKDQTTRLMEREIIEIAP
                     LAYMRGRTLDDAFVILDEAQNTTIMQMKMFLTRLGFHSKMIVNGDISQIDLPRNVKSG
                     LIDAQEKLKNIHQIDFVHFSAKDVVRHPVVAQIIRAYEYSTEVAHD"
     gene            5684..6498
                     /locus_tag="AC0DU4_000711"
                     /pseudo
     CDS             5684..6498
                     /locus_tag="AC0DU4_000711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558050.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element IS1515 family transposase"
     gene            6681..7181
                     /locus_tag="AC0DU4_000712"
     CDS             6681..7181
                     /locus_tag="AC0DU4_000712"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236710.1"
                     /translation="MIDQLSKYYSCRILTEKDIPSILSLYESNPLYFQHCPPEPNFAT
                     VKEDMLCLPEGKAKADKFFVGFWNGSDLVAVMDFVYAYPDEETVFIGLFMVDQAYQRK
                     GIGSHIVTEALAYFAKNFRKARLAYVKGNPQSQHFWEKQGFKSIGCEVKQELYTVVIA
                     EQSLED"
     gene            7184..7510
                     /locus_tag="AC0DU4_000713"
                     /pseudo
     CDS             7184..7510
                     /locus_tag="AC0DU4_000713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006267619.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TfoX/Sxy family protein"
     gene            complement(7811..8910)
                     /gene="ald"
                     /locus_tag="AC0DU4_000714"
                     /pseudo
     CDS             complement(7811..8910)
                     /gene="ald"
                     /locus_tag="AC0DU4_000714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003072563.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0000286 - alanine dehydrogenase activity
                     [Evidence IEA];
                     GO_process: GO:0042853 - L-alanine catabolic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alanine dehydrogenase"
     gene            9087..9656
                     /locus_tag="AC0DU4_000715"
     CDS             9087..9656
                     /locus_tag="AC0DU4_000715"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236711.1"
                     /translation="MESIFVKFAQYPSIETERLLLRPVTLDDAEAMFDYASDKGNTRY
                     TFPTNQSLEETKNNIAQFYLANPLGRWGIELKSNGQFIGTIDLHKIDSVLKKAAIGYI
                     INKKYWNQGLTTEANRAVIELAFEKIGMNKLTALHDKANPASGKVMEKSGMRFSHAEP
                     YACMDQHEKGRIVTRVHYVLTKEDYFANK"
     gene            9724..10374
                     /locus_tag="AC0DU4_000716"
     CDS             9724..10374
                     /locus_tag="AC0DU4_000716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-hairpin-helix domain-containing protein"
                     /protein_id="HIN4236712.1"
                     /translation="MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQ
                     AEVAAVSKDSSTEKEVKKEEKEEPLEQDLITVDVKGAVKSPGIYDLPVGSRVNDAVQK
                     AGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
                     SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD"
     gene            10358..12598
                     /locus_tag="AC0DU4_000717"
     CDS             10358..12598
                     /locus_tag="AC0DU4_000717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005215 - transporter activity [Evidence
                     IEA];
                     GO_process: GO:0009290 - DNA import into cell involved in
                     transformation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA internalization-related competence protein
                     ComEC/Rec2"
                     /protein_id="HIN4236713.1"
                     /translation="MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCL
                     FIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQNLADSVERVRILPDTIKVNGDSL
                     SFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
                     LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMGNYMTGLLL
                     GHLDTDFEEMNELYSSLGIIHLFALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPF
                     SLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIVMPNFFLTAGGVLSC
                     AYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDL
                     VFLPLLSILFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLI
                     SLALVYDLRKNIKGLTVLSLLITGLFFLTKYPLENEITMLDVGQGESIFLRDVTGKTI
                     LIDVGGKAESYKKIKKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDKEHVGDL
                     SEMTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMIVGENLPIFGSQLEVLSPRK
                     MGDGGHDDTLVLYGKFLDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSS
                     SPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGINSKVYRTDQQGAIRFKGLDSW
                     KIESVR"
     gene            12777..12965
                     /locus_tag="AC0DU4_000718"
     CDS             12777..12965
                     /locus_tag="AC0DU4_000718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810030.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236714.1"
                     /translation="MTVTKSYKYDWNTVWEYSTNYHDHQYAWIPSWSRYDSYSEYKVG
                     GGWNYARYEVINYYSGGY"
     gene            12998..13585
                     /locus_tag="AC0DU4_000719"
     CDS             12998..13585
                     /locus_tag="AC0DU4_000719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000939891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4236715.1"
                     /translation="MLQLTHVTLKTRQVILQDVDFTFKKGRVYGLLAINGSGKTTLFR
                     AISNLIPISSGNIAAPPSLFYYESIEWLDGNLSGMDYLRLIKNIWKSGLNLRDEIAYW
                     EMSDYISLPIRKYSLGMKQRLVIAMYFLSQAKCWLMDEITNGLDEYYRQKFFDRLAQI
                     DRQEQLVLLSSHYKEELVDVCDRVVTIHQGQIEEV"
     gene            13589..14773
                     /locus_tag="AC0DU4_000720"
     CDS             13589..14773
                     /locus_tag="AC0DU4_000720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236716.1"
                     /translation="MKDVSLFLLKKVFKSRLNWIVLALFVSVLGVTFYLNSQTANSHS
                     LESRLESRIAANERAINENEEKLSQMSDTSSEEYQFAKNNLDVQKNLLTRKTEILTLL
                     KEGRWKEAYYLQWQDEEKNYEFVSNDPTASPGLKMGVDRERKIYQALYPLNIKAHTLE
                     FPTHGIDQIVWILEVIIPSLFVVAIIFMLTQLFAERYQNHLDTAHLYPVSKVTFAISS
                     LGVGVGYVTVLFIGICGFSFLVGSLISGFGQLDYPYPIYSLVNQEVTIGKIQDVLFPG
                     LLLAFLAFIVIVEVVYLIAYFFKQKMPVLFLSLIGIVGLLFGIQTIQPLQRIAHLIPF
                     TYLRSVEILSGRLPKQIDNVDLNWSMGMVLLPCLIIFLLLGILFIERWGSSQKKEFFN
                     RF"
     misc_feature    14937..15068
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00558"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L20 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00558"
     gene            15084..15614
                     /gene="infC"
                     /locus_tag="AC0DU4_000721"
     CDS             15084..15614
                     /gene="infC"
                     /locus_tag="AC0DU4_000721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000848185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003743 - translation initiation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006413 - translational initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HIN4236717.1"
                     /translation="MKTIAKQDLFINDEIRVREVRLIGLEGEQLGIKPLSEAQALADN
                     ANVDLVLIQPQAKPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPTIDKGD
                     FDTKLRNARKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKM
                     DGRQMFMQLAPATDKK"
     gene            15647..15847
                     /gene="rpmI"
                     /locus_tag="AC0DU4_000722"
     CDS             15647..15847
                     /gene="rpmI"
                     /locus_tag="AC0DU4_000722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001125942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HIN4236718.1"
                     /translation="MPKQKTHRASAKRFKRTGSGGLKRFRAYTSHRFHGKTKKQRRHL
                     RKASMVHSGDYKRIKAMLTRLK"
     gene            15899..16258
                     /gene="rplT"
                     /locus_tag="AC0DU4_000723"
     CDS             15899..16258
                     /gene="rplT"
                     /locus_tag="AC0DU4_000723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019786714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HIN4236719.1"
                     /translation="MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYY
                     YAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVND
                     AVAFTALADAAKAKLGK"
     gene            16316..16696
                     /gene="gloA"
                     /locus_tag="AC0DU4_000724"
                     /gene_synonym="lguL"
     CDS             16316..16696
                     /gene="gloA"
                     /locus_tag="AC0DU4_000724"
                     /gene_synonym="lguL"
                     /EC_number="4.4.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactoylglutathione lyase"
                     /protein_id="HIN4236720.1"
                     /translation="MASKMLHTCLRVENLEKSIAFYQDAFGFKELRRRDFPDHAFTIV
                     YLGLEGDDYELELTYNYDHGPYVVGDGFAHIALSTPDLEALHQEHSAKGYEVTEPNGL
                     PGTTPNYYFVKDPDGYKVEVIREK"
     gene            16946..17746
                     /locus_tag="AC0DU4_000725"
     CDS             16946..17746
                     /locus_tag="AC0DU4_000725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HIN4236721.1"
                     /translation="MNPTCKKRLGVIRLETMKVVAQEEIAPAIFELVLEGEMVEAMRA
                     GQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIEGAGTAIFSTLSQGDTLDVMG
                     PQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHGRGVKVVTVLGFANKDAVILK
                     TELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHP
                     RAYLSLESRMACGMGACYACVLKVPESETVSQRVCEDGPVFRTGTVVL"
     gene            17757..18695
                     /locus_tag="AC0DU4_000726"
     CDS             17757..18695
                     /locus_tag="AC0DU4_000726"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000210709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004152 - dihydroorotate dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HIN4236722.1"
                     /translation="MTTNRLQVSLPGLDLKNPIIPASGCFGFGQEYAKYYDLDLLGSI
                     MIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGLEVVLAEKLPWLEREYPNLPIIA
                     NVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGLLIGQDPDLAYDVVKAA
                     VEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVGMRFDLKTRKPILANGT
                     GGMSGPAVFPVALKLIRQVAQTTDLPIIGMGGVDSAEAALEMYLAGASAIGVGTANFT
                     NPYACPVIIENLPKVMDKYGISSLEELRQEVKESLR"
     gene            18737..20770
                     /locus_tag="AC0DU4_000727"
     CDS             18737..20770
                     /locus_tag="AC0DU4_000727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004040 - amidase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HIN4236723.1"
                     /translation="MNLGEFWYNKINKNRGRRLMKKVRFIFLALLFFLASPEGAMASD
                     GTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIKADANYAENEWLKQGDDYFYLKSGGY
                     MAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDAWFYIKA
                     DGQHAEKEWLQIKEKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFH
                     IKENGNYADKEWIFENGHYYYLKSGGYMAANEWIWDKESWFYLKFDGKIAEKEWVYDS
                     YSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYDSHSQAWYYFKSGGYM
                     TANEWIWDKESWFYLKSDGKMAEKEWVYDSHSQAWYYFKSGGYMAKNETVDGYQLGSD
                     GKWLGGKATNKNAAYYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAIT
                     ISGLSGYMKTEDLQALDASKDFIPYYESDGHRFYHYVAQNASIPVASHLSDMEVGKKY
                     YSADGLHFDGFKLENPFLFKDLTEATNYSAEELDKVFSLLNINNSLLENKGATFKEAE
                     EHYHINALYLLAHSALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFDDVDKGILG
                     ATKWIKENYIDRGRTFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKD"
     gene            complement(20831..22486)
                     /gene="pavA"
                     /locus_tag="AC0DU4_000728"
     CDS             complement(20831..22486)
                     /gene="pavA"
                     /locus_tag="AC0DU4_000728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_094859469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rqc2 family fibronectin-binding protein PavA"
                     /protein_id="HIN4236724.1"
                     /translation="MSFDGFFLHHIVEELRSELVNGRIQKINQPFEQELVLQIRSNRQ
                     SHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEI
                     TVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGS
                     TYIAPPSTESLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEK
                     LSAFRNFFNQENKPCLTETSFSPVPFANQVGEPFANLSDLLDTYYKDKAERDRVKQQA
                     SELIRRVENELQKNRHKLKKQEKELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILD
                     NYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVET
                     VLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQN
                     EELTFKMARKEELWFHAKDIPGSHVVISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQ
                     VDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKIASMKKS"
     gene            22591..23088
                     /gene="ybeY"
                     /locus_tag="AC0DU4_000729"
     CDS             22591..23088
                     /gene="ybeY"
                     /locus_tag="AC0DU4_000729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004540 - RNA nuclease activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HIN4236725.1"
                     /translation="MYIEMVDETGQVSKEMLQQTQEILEFAAQKLGKEDKEMAVTFVT
                     NERSHELNLEYRNTDRPTDVISLEYKPELEIAFDEEDLLENSELAEMMSEFDAYIGEL
                     FISSDKAHEQAEEYGHSFEREMGFLAVHGFLHINGYDHYTPEEEAEMFGLQEEILTAY
                     GLTRQ"
     gene            23069..23464
                     /locus_tag="AC0DU4_000730"
     CDS             23069..23464
                     /locus_tag="AC0DU4_000730"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000378166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family protein"
                     /protein_id="HIN4236726.1"
                     /translation="MDSQDNKRKWKNRDLISSLEFALTGIFTAIKEERNMRKHAVTAL
                     VVILAGFGFQVSRIEWLFLLLSIFLVVAFEILNSAIENVVDLASHYHFSMLAKNAKDM
                     AAGAVLVVSLFAALTGALIFLPRIWDLLF"
     gene            23481..24380
                     /gene="era"
                     /locus_tag="AC0DU4_000731"
     CDS             23481..24380
                     /gene="era"
                     /locus_tag="AC0DU4_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HIN4236727.1"
                     /translation="MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKI
                     MGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGD
                     DMIIERLKAAKIPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSR
                     LVDILSENLDEGFQYFPSDQITDHPERFLVSEMLREKVLHLTREEIPHSVAVVVDSMK
                     RDEETDKVHIRATIMVERDSQKGIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWV
                     KVKKNWRDKKLDLADFGYNEREY"
     gene            24429..25253
                     /gene="mutM"
                     /locus_tag="AC0DU4_000732"
     CDS             24429..25253
                     /gene="mutM"
                     /locus_tag="AC0DU4_000732"
                     /EC_number="3.2.2.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001114577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008534 - oxidized purine nucleobase
                     lesion DNA N-glycosylase activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-formamidopyrimidine glycosylase"
                     /protein_id="HIN4236728.1"
                     /translation="MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRE
                     LPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGG
                     TLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSH
                     LLDQTLVAGLGNIYVDEVLWRAQIHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGS
                     TIRTYTNAFGEDGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD"
     gene            25253..25858
                     /gene="coaE"
                     /locus_tag="AC0DU4_000733"
     CDS             25253..25858
                     /gene="coaE"
                     /locus_tag="AC0DU4_000733"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259526.1"
                     /note="Dephospho-CoA kinase (CoaE) performs the final step
                     in coenzyme A biosynthesis; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004140 - dephospho-CoA kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HIN4236729.1"
                     /translation="MGKIIGITGGIASGKSTVTNFLRQQGFQAVDADAVVHQLQKPGG
                     RLFEALVQHFGQEIILENGELNRPLLASLIFSNPEEQKWSNQIQGEIIREELATLREQ
                     LAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDAQVERLMKRDQLSKDEAESRLAA
                     QWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD"
     gene            25845..27044
                     /locus_tag="AC0DU4_000734"
     CDS             25845..27044
                     /locus_tag="AC0DU4_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter PmrA"
                     /protein_id="HIN4236730.1"
                     /translation="MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSQQ
                     VAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYW
                     LIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAE
                     LFGIRTVFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLF
                     LTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDK
                     VGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPK
                     AGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRT
                     LLKVKEI"
     gene            27044..27193
                     /gene="rpmG"
                     /locus_tag="AC0DU4_000735"
     CDS             27044..27193
                     /gene="rpmG"
                     /locus_tag="AC0DU4_000735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HIN4236731.1"
                     /translation="MRVKINLKCSSCDSINYLTSKNSKTHPDKIEVLKYCPKERKVTL
                     HLESK"
     gene            27233..27466
                     /gene="secG"
                     /locus_tag="AC0DU4_000736"
     CDS             27233..27466
                     /gene="secG"
                     /locus_tag="AC0DU4_000736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015136 - sialic acid transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0015739 - sialic acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HIN4236732.1"
                     /translation="MYNLLLTILLVLSVVIVIAIFMQPTKNQSSNVFDASSGDLFERS
                     KARGFEAVMQRLTGILVFFWLAIALALTVLSSR"
     gene            27568..29922
                     /gene="rnr"
                     /locus_tag="AC0DU4_000737"
     CDS             27568..29922
                     /gene="rnr"
                     /locus_tag="AC0DU4_000737"
                     /EC_number="3.1.13.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HIN4236733.1"
                     /translation="MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMER
                     KHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAI
                     DGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
                     KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVL
                     ESMDIVSEFPEAVVKEAESVPDAPSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIK
                     ALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVVPMLPERLSNGICSL
                     NPQVDRLTQSAIMEIDKHGRVVNYTIIQTVIKTSFRMTYSDVNDILAGDEEKRKEYHK
                     IVPSIELMAKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIE
                     SFMLMANETVAEHFSKLDLPFIYRIHEEPKAEKVQKFIDYASSFGLRIYGTASEISQE
                     ALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSPIRRYPD
                     LLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYV
                     GEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVG
                     QQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSHSGRGRGSNRRSDKKEDKRKS
                     GRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK"
     gene            29885..30352
                     /gene="smpB"
                     /locus_tag="AC0DU4_000738"
     CDS             29885..30352
                     /gene="smpB"
                     /locus_tag="AC0DU4_000738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HIN4236734.1"
                     /translation="MAKGEGKVVAQNKKARHDYTIVDTLEAGMVLTGTEIKSVRAARI
                     NLKDGFAQVKNGEVWLSNVHIAPYEEGNIWNQEPERRRKLLLHKRQIQKLEQETKGTG
                     MTLVPLKVYIKDGYAKLLLGLAKGKHDYDKRESIKRREQNRDIARVMKAVNQR"
     gene            30368..31228
                     /gene="tehB"
                     /locus_tag="AC0DU4_000739"
     CDS             30368..31228
                     /gene="tehB"
                     /locus_tag="AC0DU4_000739"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0046690 - response to tellurium ion
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase TehB"
                     /protein_id="HIN4236735.1"
                     /translation="MEKLVAYKRMPLWNKQTMPEAVQQKHNTKVGTWGKITVLKGALK
                     FIELTEEGEVLAEHLFEAGADNPMAQPQAWHRVEAATDDVEWYLEFYCKPEDYFAKKY
                     NTNPVHSEVLEAMETVKQGKALDLGCGQGRNSLFLAQQDFDVTAVDQNGLALEILQSI
                     VEQEDLDMPVGLYDINSASIEQEYDFIVSTVVLMFLQADRIPAIIQNMQEKTSVGGYN
                     LIVCAMDTEDYPCSVNFPFTFKEGELADYYKDWELVKYNENPGHLHRRDENGNRIQLR
                     FATLLAKKIK"
     gene            31301..32254
                     /gene="coiA"
                     /locus_tag="AC0DU4_000740"
     CDS             31301..32254
                     /gene="coiA"
                     /locus_tag="AC0DU4_000740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000495911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein CoiA"
                     /protein_id="HIN4236736.1"
                     /translation="MFVARDARGELVNVLEDKLEKQAYTCPACGGQLHLRQGPSVRTH
                     FAHKSLKDCDFFFENESPEHLANKESLYHWLKKETKVQLEYPLSELKQIADVFVNGNL
                     ALEVQCSPLPQKVLKERSEGYRSQGYQVLWLLGQKLWLKERLTRLQQGFLYFSQNMGF
                     YVWELDKEKQVLRLKYLIYQDLRGKLHYQIKEFSYGQGSLLEILRLPYKRQKISHFTV
                     SEDKDICRYIQQQLYYQNLFWMKEQAEAYQKGENILTYGLKEWYPQIRPIVGKFFQIE
                     QDLTSYYQHFYTYYQKNPQNDWQKLYPPAFYQQYFLKNMVE"
     gene            32273..34075
                     /gene="pepF"
                     /locus_tag="AC0DU4_000741"
     CDS             32273..34075
                     /gene="pepF"
                     /locus_tag="AC0DU4_000741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HIN4236737.1"
                     /translation="MVLQRNEINEKDTWDLSTIYPTDQAWEEALKDLTEQLETVAQYE
                     GHLLDSADNLLEITEFSLEMERQMEKLYVYAHMKNDQDTREAKYQEYYAKAMTLYSQL
                     DQAFSFYDPEFMEISEKQYADFLEAQPKLQVYQHYFDKLLQGKDHVLSQREEELLAGA
                     GEIFGSASETFAILDNADIVFPYVLDDDGKEVQLSHGTYTRLMESKKREVRRGAYQAL
                     YATYEQFQHTYAKTLQTNVKVQNYRAKVRNYKSARHAALAANFVPESVYDNLVAAVRK
                     HLPLLHRYLELRSKILGISDLKMYDVYTPLSSVEYNFTYQEALKKAEDALAVLGEDYL
                     SRVKRAFSERWIDVYENQGKRSGAYSGGSYDTNAFMLLNWQDNLDNLFTLVHETGHSM
                     HSSYTRETQPYVYGDYSIFLAEIASTTNENILTEKLLEEVEDDATRFAILNNFLDGFR
                     GTVFRQTQFAEFEHAIHQADQNGEVLTSDFLNKLYADLNQEYYGLSKEDNPEIQYEWA
                     RIPHFYYNYYVYQYSTGFAAASALAEKIVHGSQEDRDRYIDYLKAGKSDYPLNVMRKA
                     GVDMEKEDYLNDAFAVFERRLNEFEALVEKLGLA"
     gene            34077..34790
                     /locus_tag="AC0DU4_000742"
     CDS             34077..34790
                     /locus_tag="AC0DU4_000742"
                     /EC_number="2.1.-.-"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0008171 - O-methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HIN4236738.1"
                     /translation="MVESYSKNANHNMRRPVVKEEIVDLMRQRQKQVTGFLKELEEFA
                     RKENIPIIPHETVAYFRFLMETMQPKNILEIGTAIGFSALLMAEHAPNAKITTIDRNP
                     EMIGFAKENFAQFDSRKQITLLEGDAVDVLSTLTESYDFVFMDSAKSKYIVFLPEILK
                     HLEVGGVVVLDDIFQGGDVAKDIMEVRRGQRTIYRGLQKLFDATLDNPELTATLVPLG
                     DGILMLRKNVADVQLSESE"
     gene            34857..35798
                     /gene="prsA"
                     /locus_tag="AC0DU4_000743"
     CDS             34857..35798
                     /gene="prsA"
                     /locus_tag="AC0DU4_000743"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase PrsA"
                     /protein_id="HIN4236739.1"
                     /translation="MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFY
                     EQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAG
                     MTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAK
                     EVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGV
                     SDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIG
                     KELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE"
     gene            complement(35915..>35999)
                     /locus_tag="AC0DU4_000744"
     CDS             complement(35915..>35999)
                     /locus_tag="AC0DU4_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HIN4236740.1"
                     /translation="IDYYNNKRIKVKLKGLSPVQYRTKSFR"
BASE COUNT        10856 a         6719 c         8083 g        10341 t
ORIGIN      
        1 ggctccgacg gattaagttg ctttcgtgaa taccaaaatc agccgcaatt tgttcataag
       61 ttcgatattc tcgcacatat tgaagagtgg ccataagaag gtcttctagg cttaatttag
      121 gttttcgtcc accttttgcg tgtttaagtt gataagctgt ttttaataca gctaatatct
      181 cttcaaaagt cgtgcgctga acaccaacaa gacgcttaaa tcgtgcatca gttagttgtt
      241 tacttgcttc atcattcata gaactactat accatatttt gtttcgcagg aagtctattg
      301 gaaagtaaga aatattgaag ctgaggctat tagaagaaat tgtgagcgtg gtgctatttt
      361 ttcaggtaaa ataaaatatc acgaagattc acagtttaaa ggagatcact atgttgaatg
      421 ttatgctgtt ttagataata cggttatagc aagagataga ataacagtcc ctatcgatcc
      481 gttatgtgga aaagatttta tagagtagca tataattgat tcttaactgg aatactcact
      541 atctctttac atcaagaaaa tgactaaaca gggaagtttg ccttcttccc tttttttgtt
      601 atactagtag aagaaaaaat tagaaagatt tgtgggtgtc aaacagccca gtggggtgtt
      661 ttaatatgga cttaggtccc acccaaagag gtattagtgt cgtgtctcaa tcttatatca
      721 atgttatcgg tgctggtttg gcaggttctg aagcagctta ccaaatcgca gagcgtggta
      781 ttccagttaa actatatgaa atgcgtggtg tcaagtctac accccagcat aaaacagaca
      841 attttgctga gttggtttgt tccaattctt tgcgtgggga tgctttgaca aatgcagttg
      901 gtcttctcaa ggaagaaatg cgtcgcttgg gttctgttat cttggaatct gctgaggcta
      961 cacgtgttcc tgcaggtggt gcccttgcag tggaccgtga tggtttctct caaatggtga
     1021 ccgaaaaagt tgccaaccac cccttgattg aagtggttcg tgatgaaatt acagaattgc
     1081 cgacagatgt tattacggtt atcgctactg gtcctttgac aagtgatgcc ttggctgaaa
     1141 agattcatgc tcttaatgac ggtgctggtt tttatttcta cgatgcggca gcgcctatta
     1201 tcgatgtcaa cactatcgat atgagcaagg tctacctcaa atcacgttat gataagggag
     1261 aagcggccta cctcaatgcc cctatgacca agcaagaatt tatggatttc catgaagctt
     1321 tggtcaatgc agaagaagca ccgcttagtt cttttgaaaa agaaaagtac tttgaaggat
     1381 gtatgcctat cgaagtcatg gccaaacgtg gcattaaaac tatgctttat ggccctatga
     1441 agccagtcgg tcttgagtac ccagacgact atacaggacc tcgtgatgga gaatttaaaa
     1501 caccttatgc ggttgtgcaa cttcgtcagg ataatgcagc tggtagcctc tacaatattg
     1561 ttggtttcca gacccacctc aaatggggag aacaaaagcg tgtcttccaa atgattccgg
     1621 gtcttgaaaa tgcggagttt gtccgttatg gtgtgatgca tcgcaattct tacatggatt
     1681 caccaaatct tcttgagcag acttaccgtt ctaagaaaca accaaatctc ttctttgctg
     1741 gtcaaatgac gggtgtggaa ggctatgttg agtcggcggc ttcaggctta gttgcgggaa
     1801 ttaacgcagc tcgtctcttc aaggaagaaa gcgaggctat tttccccgag acgacagcga
     1861 ttggaagctt agctcattac attacccatg ccgacagcaa acatttccaa ccaatgaatg
     1921 tcaattttgg gatcatcaag gagttggaag gcgagcgtat ccgtgataag aaggctcgtt
     1981 atgaaaaaat tgcagagcgt gcccttgccg acttagagga atttttgact gtctaatttt
     2041 tttgaaagaa ttgctcatga tactataaaa atcttagaaa ttgtgataaa ataggtagga
     2101 tgaaagaagg agagtgaaaa tggcgaatcc caagtataaa cgtattttaa tcaagttatc
     2161 aggtgaagcc cttgccggtg aacgtggcgt agggattgat atccaaacag ttcaaacaat
     2221 cgcaaaagag attcaagaag ttcatagctt aggtatcgaa attgcccttg ttatcggtgg
     2281 aggaaatctc tggcgtggag aacctgcagc agaagcaggt atggaccgtg ttcaggcaga
     2341 ttacacagga atgcttggga ctgttatgaa tgctcttgtg atggcagatt cattgcaaca
     2401 agttggggtt gatacacgtg ttcaaacagc tattgccatg caacaagtgg cagagcctta
     2461 tgtccgtgga cgtgcccttc gtcaccttga aaaaggccgt atcgttatct ttggtgctgg
     2521 aattggttca ccttacttct cgacagatac aacagcggcc cttcgtgcag ctgaaatcga
     2581 agcagatgcc atcctcatgg ctaaaaatgg tgtcgatggt gtttacaatg ccgatcctaa
     2641 gaaagataag acagctgtta agtttgaaga attgacccac cgtgacgtta tcaataaagg
     2701 tcttcgtatc atggactcaa cagcttcaac cctctcaatg gacaacgaca ttgacttggt
     2761 tgtattcaac atgaaccaac caggcaacat caaacgtgtc gtatttggtg aaaatatcgg
     2821 aacaacagtt tcaaataata tcgaagaaaa ggaataagaa agaatatggc taacgcaatt
     2881 attgaaaaag ctaaagagag aatgacccag tctcaccaat cacttgctcg tgaatttggt
     2941 ggtatccgtg ctggtcgtgc caatgcaagc ttgcttgacc gtgtacatgt agaatactat
     3001 ggagtcgaaa ctcctcttaa ccaaatcgct tcaattacga ttccagaagc gcgtgttttg
     3061 ttggtaacac catttgacaa gtcttcattg aaagacatcg aacgtgcctt gaacgcttct
     3121 gatattggta tcacaccggc taatgacggt tctgtgattc gcttggttat cccagctctt
     3181 acagaagaaa ctcgtcgtga ccttgctaaa gaagtgaaga aggtcggcga aaatgctaaa
     3241 gtggctgtcc gcaatatccg tcgcgatgct atggacgaag ctaagaaacg agaaaaagca
     3301 aaagaaatca ctgaagacga attgaagact cttgaaaaag acattcaaaa agtaacagac
     3361 gatgctgtta aacacatcga cgacatgact gctaacaaag agaaagaact tttggaagtc
     3421 taaaaataaa cagaaaaact cagttggcat tgctggctga gttttattcg aaagaaggaa
     3481 atatgaatac aaatcttgca agttttatcg ttggactgat catcgatgaa aacgaccgtt
     3541 tttactttgt gcaaaaggat ggtcaaacct atgctcttgc taaggaagaa ggccaacata
     3601 cagtagggga tacggtcaaa ggttttgcat acacggatat gaagcaaaaa ctccgcctga
     3661 caaccttaga agtgactgcc actcaggacc aatttggttg gggacgtgtc acagaggttc
     3721 gtaaggactt gggtgtcttt gtggatacag gccttcctga caaggaaatc gttgtgtcac
     3781 tcgatattct ccctgagctc aaggaactct ggcctaagaa gggcgaccaa ctctacatcc
     3841 gtcttgaagt ggataagaaa gaccgtatct ggggcctctt ggcttatcaa gaagacttcc
     3901 aacgtcttgc tcgtcctgcc tacaacaaca tgcagaacca aaactggcca gccattgttt
     3961 accgtctcaa gctgtcagga acttttgttt acctaccaga aaataatatg cttggtttta
     4021 ttcatcctag cgagcgttac gcagagccac gtttggggca agtattagat gcgcgcgtta
     4081 ttggtttccg tgaagtggac cgcactctga acctctccct caaaccacgc tcctttgaaa
     4141 tgttggaaaa cgatgctcag atgattttga cttatttgga aagcaatggc ggtttcatga
     4201 ccttaaatga caagtcatct ccagacgaca tcaaggcaac ctttggcatt tctaaaggtc
     4261 agttcaagaa agctttaggt ggtcttatga aggctggtaa aatcaagcag gaccagtttg
     4321 ggacagagtt gatttaggga ggcttatgag aaaatcattt tacacttggc tcatgaccga
     4381 gcgcaatcct aaaagtaaca gtcccaaagc aattttggca gacctcgctt ttgaagagtc
     4441 agcctttcca aaacacacag atgattttga tgaggtcagt cgctttttgg aggagcatgc
     4501 cagtttctct tttaacctag gagattttga cagcatttgg caggaatatc tagaacacta
     4561 gcatttattc attgggtttg ggctagtaat ttctccatcc ctctgctata ataaaaagaa
     4621 ataaaaggat tagagaggtt ctttatttga aggaacattc aatagacatt caactgagtc
     4681 atccagatga cctgtttcat ctttttggtt ccaatgaacg ccatcttcgt ttgatggaag
     4741 aagagcttga tgttgtgatt catgctcgta cggagattgt ccaggttttg ggagaagagt
     4801 ctgcctgtga ggaagcccgt caagttattc aggctttgat ggtcttggta aatcgtggga
     4861 tgaccgttgg tacgccagat gtagtcactg cgattagcat ggtcaaaaat gatgaaattg
     4921 acaagtttgt cgccctttac gaagaagaaa ttatcaaaga taatactggg aaacctatcc
     4981 gtgtcaaaac cctagggcaa aagctttatg tggacagtgt caaacagcat gatgtgacct
     5041 ttggaattgg gccagcaggt acagggaaga ccttccttgc agtgaccttg gcagtgactg
     5101 cccttaaacg tgggcaagtc aagcgaatta tcctaactcg tccagcggtg gaagcgggag
     5161 agagtcttgg atttcttccg ggtgatctta aggagaaggt ggatccttac cttcgtcctg
     5221 tttacgatgc cttgtatcaa attcttggga aagaccaaac gactcgtctc atggagcgtg
     5281 aaattatcga aattgcgccc cttgcctata tgcgtggccg gaccttggat gatgcctttg
     5341 tcattctcga tgaggcgcaa aacacgacca tcatgcagat gaagatgttc ttgacgcgtt
     5401 taggttttca ttctaagatg attgtcaatg gagatattag tcagattgac ctgccacgta
     5461 atgtcaagtc cggtttgatt gatgctcaag agaaactcaa gaacatccat cagattgact
     5521 ttgttcattt ttcagccaag gatgtggttc gccatcctgt tgtcgctcag attatccgag
     5581 cctatgaata ttctactgaa gttgcacacg actgattttg aggaagttcg cctgcaaaag
     5641 aatagacttg ttcggtaact gtaaaaagtg ttatactatt tttatggaaa cagtatacga
     5701 caaagcacaa aaacttaact caaaaaactt caaactattg attggtgtca aaaaggaaac
     5761 ctttcaactc atgctagaac acctgaattc agcctatcag attcagcacc gaaaaggtgg
     5821 acgtccacgt agtctgccca tggaagacca gctcattatg accctccgtt acttgcgata
     5881 ttatcccact cagcgtctgc tggcctttga ttttggcgtc ggtgtagcta cggtaaatgc
     5941 catcatcact tgggtggagg atacacttcg tgcgtcaggt agctttgatt tggaccattt
     6001 agaagccccg agtgctgctg tggctattga cgtgaccgaa agtccgattc agcgtccaaa
     6061 caaaaccaaa gcaaaaatta ttctggtaaa aagaaacgac acaccttaaa aactcaaatt
     6121 atgctggatt tgacgacaca taaagtctgt caaatggcct tttctgacgg acatacgcat
     6181 gattttactc tcttcaaaga aagtattgga caaagtttgc ctgaaacgac gcttgccttt
     6241 gttgacctag gttatttagg catcttgaaa tttcatgaga atactttcat tcctgctaaa
     6301 aattccaaaa atcgccgcct gagtgaggat gataagcagt taaataaaga gatgtcagcg
     6361 atacgaattg aaattgaaca ttttaacgct aaattcaaga ccttccaaat catgtcagtc
     6421 ccttatcgta accgcagaaa acgtttcgag ttacgggcgg aattaatttg tgccatcatc
     6481 aattatgaag tgaactagat tccgaacaag tctaatatac ttttgagaga ggaaaatcca
     6541 gttgtatagg ctaaaggttt tatccaaagg tctgagacaa cgattaggca cgatggaaag
     6601 aacttttatg tggctgatga cgatcagtgc atcttcctgt gtcataatca cagggcacaa
     6661 gaaagtagga atttgaaaag atgattgacc aactatctaa gtattacagt tgtaggatac
     6721 taactgaaaa ggatattcca agtattttat ctttatatga aagtaatcct ctgtattttc
     6781 agcattgtcc accagagcca aattttgcaa ctgtaaaaga ggacatgctt tgtctacctg
     6841 aaggtaaagc taaggctgat aagttttttg ttggattttg gaatggatct gaccttgtgg
     6901 ctgttatgga ttttgtctat gcatatcctg atgaggagac tgtttttatt ggtttgttta
     6961 tggttgatca agcctatcag agaaaaggga ttggtagtca tattgtgaca gaagcactag
     7021 cttattttgc taagaacttt cgaaaggcac gtttggctta tgttaaggga aatccgcaat
     7081 ctcagcattt ttgggaaaag cagggcttta aatcaattgg atgcgaggtt aagcaagaac
     7141 tctatacggt tgttatcgct gaacagagcc tagaagatta gaaatggcat caagtaagaa
     7201 ctatttggaa tttgttttgg aacaattatc aggattagat gatgtgactt accgttccat
     7261 gatgggggag tatattcttt acttccgcgg caagattatt ggcggcattt atgacgatcg
     7321 ctttttagtt aaacccgtgc aagcagtctt agataagatt gaccaatctt cttttgagtt
     7381 tccatacaaa ggtgccaaag aaatgatttg agtggaagaa cttgataata agatgtttct
     7441 ataagaccta attttagcta tgtataacca actgccaacg cccaaaccta aaaagaaaaa
     7501 gcaagggtga acgaagtaaa aaagaagtct gctaaggccc tgtctttgca cgggtaaaat
     7561 tttatatata aaaagaagct gggactaaag agctcagctt cctttggttt atataattgt
     7621 cattacaaga cgaagtggtt gggcgaaact ctgttgactt tattcaattt agagtttctt
     7681 atgcacaatt gagtctggaa cgaaagtctc cagttgcaaa gtatacagta caataaacca
     7741 acgatgtaat agctgatgac acaaagcaca gtgggtagga cttgcgaagt cacccttttc
     7801 ttttcaaaat ttatactaaa tcattgatat cagtgtagtc acgattaagt ccttgagcaa
     7861 ctggtaggtt agtcaagtaa ccttgataag tagtcacacc ttgacgcaag ccttcatctt
     7921 cagagattgc ttgtgcgaat cctttgccag ccaaagcttc gatataagga agagtgacat
     7981 tggttagggc gatggttgaa gtgcgagcaa ccgcaccagg gatattggca acggcatagt
     8041 ggagaacacc gtgtttttca tagacgggtt catcgtgcgt tgtcacacgg tcagctgttt
     8101 cgataacgcc accttggtca acagcaacgt caacgataca gagcctggac gcatttgttt
     8161 gaccatctca tctgtcacca attccggtgc ttttgcacca gggatgagaa tggctccaat
     8221 caccacatca gcatctctca cacttgcttc aatgttgaat gaattagaca taagagtttg
     8281 aatttgactt ccaaagactt cttctagaac tgagagacgc ttggaactaa tatctaaaat
     8341 agtcacttga gcaccaagac caagggcgat gcgggcagca tgtgtaccga cgacaccacc
     8401 accgatgata gttacttttc cttttggaac acctggtaca ccaccaagta gaacaccaga
     8461 gccaccagct tgcttagtaa ggaagtgagc tccgatttga acagccatac gacctgcaac
     8521 ctcactcata ggaacgagga gcggtagttg tccttgattg tcacgaacag tttcagttgt
     8581 ttttgctgtt aacatagcat ctgctaattc tggagcagcg gccatgtgca agtaggtgaa
     8641 gagaagaaga tcgtcgcgca agtaaccgta ttcagaactt aaagattctt ttactttcac
     8701 aaccaactct gctgcccaag cttcaccagc agtagcgaca atctcagctc cttgcttttg
     8761 atagtcagca tcagtaaagc cagaaccgag accagcattt gtttcgataa ggacacgatg
     8821 accacgacta actaagctat gaacacctgc aggtgtgagg gcgacacggt tttcgttatt
     8881 tttaatttct tttgggattc cgattaacat tgagataacc tacctttcaa ttgacggtct
     8941 tgttttggtt gtcacattcc agttcataaa tcaaaaatgt gacggtttca ttgtatatga
     9001 aaccgcttca aaaatcaaga aaaacttgtc atccaaattt ttttatgcta gactagtgaa
     9061 aatcaagctc taatggaggg aaaagtatgg aatcaatatt tgtgaaattt gcccagtatc
     9121 cgtctataga aacggagcgt ttattgctca gacctgtaac tttggatgat gcggaagcaa
     9181 tgtttgacta tgcctcggac aagggtaata cacgttacac ttttccaacc aatcaaagct
     9241 tggaagaaac caagaataac attgctcagt tctacttggc taatcccttg ggacgttggg
     9301 gaatagaact aaaaagcaat ggtcagttta ttggaaccat tgacttgcac aagattgatt
     9361 ctgttcttaa gaaggcagct attggctaca ttatcaataa aaagtattgg aatcaaggat
     9421 taacgacaga agccaatcgt gctgtgattg agctagcttt tgagaagata gggatgaata
     9481 agttgactgc ccttcacgat aaggctaatc ccgcgtcagg aaaggtcatg gagaaatcag
     9541 gcatgcgttt ttcccatgca gaaccatatg cttgtatgga ccagcatgaa aaaggccgaa
     9601 tcgtgacaag agttcattat gtcttgacca aggaagacta ttttgcaaat aaataagcag
     9661 ttgaaaagaa atttttcgac tgttttttct tcctcttacg aataatctaa gagaggagaa
     9721 aatatggaag caattatcga gaaaatcaaa gagtataaaa tcatcgtcat ctgtactggt
     9781 ctgggcttgc ttgtaggagg atttttcctg ctaaaaccag ctccacaaac acctgtcaaa
     9841 gagacgaatt tgcaggctga agttgcagct gtttccaagg actcatcgac cgaaaaggaa
     9901 gtgaagaagg aagaaaagga agaacccctt gaacaagatc taatcacagt agatgtcaaa
     9961 ggtgctgtca aatcgccagg gatttatgac ttgcctgtag gtagtcgagt caatgatgct
    10021 gttcagaagg ctggtggctt gacagagcaa gcagacagca agtcgctcaa tctagctcag
    10081 aaagttagtg atgaggctct ggtttacgtt cctactaagg gagaagaagc agttagtcaa
    10141 cagactggtt cggggacagc ttcttcaaca agcaaggaaa agaaggtcaa tctcaacaag
    10201 gccagtctgg aagaactcaa gcaggtcaag ggactgggag gaaaacgagc tcaggacatt
    10261 attgaccatc gtgaggcaaa tggcaagttc aagtcagtag acgagctcaa gaaggtctct
    10321 ggcattggtg gcaaaacaat agaaaagctt aaagactatg ttacagtgga ttaagaattt
    10381 ctctattccc ctaatttacc tgagttttct attactttgg ctttattacg ctattttctc
    10441 agcatcttat cttgctttgt tgggctttgt ttttctgcta gtctgtctct ttatccaatt
    10501 tccgtggaaa tctgctggta aagttctaat aatttgcgga atctttggat tttggtttgt
    10561 ttttcaaaat tggcaacaga gtcaagcgag tcaaaatctg gcggattctg ttgaaagggt
    10621 acggattttg cctgatacta ttaaggttaa tggtgatagt ctatcctttc gtggcaagtc
    10681 taacggtcgt gctttccaag tctattataa actccagtcc gaggaggaga aagaagcctt
    10741 tcaagcttta actgacctgc atgagatagg actagaaggg aagctttcgg agccagaagg
    10801 gcagagaaat tttggtggct ttaattacca agcctatctg aagactcagg gaatttacca
    10861 gactctcaat atcaaaacaa tccagtcact tcaaaagatt ggcagttggg atataggaga
    10921 aaacttgtcc agtttacgtc gaaaggctgt ggtttggatt aagacgcact ttccagaccc
    10981 tatgggcaat tacatgacag gactcttgct gggacatctg gacaccgact ttgaggagat
    11041 gaatgagctt tattccagtc taggaattat ccacctcttt gccctatctg gcatgcaggt
    11101 aggttttttc atgaatggat ttaagaaact tctcttgcga ttgggcttga cccaagaaaa
    11161 gttgaaatgg ctgacttatc ccttttccct tatctatgcg ggactaactg gattttcagc
    11221 atcggttatt cgcagtctct tgcaaaagct actggctcaa catggggtta agggcttgga
    11281 taattttgcc ttgacggtgc ttgtcctctt tattgtcatg ccaaactttt tcttgacagc
    11341 aggaggagtc ttgtcctgcg cttatgcttt tatcctgacc atgaccagca aagaagggga
    11401 ggggctcaag gctgttacta gtgaaagtct agtcatctcc ttgggcatat tgcccattct
    11461 atccttctat tttgcggaat ttcaaccttg gtctatcctt ttgacctttg tcttttcctt
    11521 tctttttgac ttggtcttct taccgctctt gtctatctta tttgtccttt cctttctcta
    11581 tccagtcatt cagctgaact ttatctttga atggttagag ggcattattc gcttggtctc
    11641 gcaggtggca aggagaccac ttgtctttgg tcaacccaac gcatggcttt taatcttatt
    11701 gttaatttcc ttggctttgg tctatgattt gaggaaaaac attaaaggat taacagtatt
    11761 gagtttattg attacaggtc tctttttcct taccaagtat ccactggaaa atgaaatcac
    11821 catgctggat gtggggcaag gagaaagtat tttcctacgg gatgtaactg ggaaaaccat
    11881 tctcatagat gtaggtggta aggcagaatc ttataagaaa atcaaaaaat ggcaagaaaa
    11941 gatgacgacc agcaatgccc agcgaacctt gattccctat ctcaaaagtc gaggagtagc
    12001 taagattgac cagctaattt tgactaacac ggacaaggag catgttggag atttgtcaga
    12061 gatgaccaag gctttccatg taggggagat tctagtatca aaagacagtc tgaaacagaa
    12121 ggaatttgtg gcagaactac aggcgactca aacaaaggtg cgtagtatga tagtagggga
    12181 gaacttgccc atttttggaa gtcagttaga agttctatct ccaaggaaaa tgggagatgg
    12241 aggacacgat gataccctag ttctgtatgg gaaattcttg gataagcaat ttctcttcac
    12301 gggaaatttg gaggagaaag gagagaagga cttgctgaag cactatccag acttgaaagt
    12361 aaatgttttg aaagctagcc aacatggcaa taaaaaatca tcaagtccag cctttctaga
    12421 aaaactcaaa ccagagctta ctcttatctc agttggaaag agcaatcgaa tgaaactccc
    12481 ccatcaggaa acattgacac gactggaagg tatcaatagc aaagtttatc gaactgacca
    12541 gcaaggagct atacgtttta aggggttgga tagttggaaa atcgaaagtg ttcgatagga
    12601 aggataaatg ttgtagatta gtgaaataaa ctaaaaattt gttgcataat aatgataaaa
    12661 atggtataat gaaaacgtat tcaatattga ggatataaaa tcattaaaaa tcagcaaaag
    12721 ttgttttatt agttagttta taatctattg gtcttcttca gtccagtgta tctgctgtga
    12781 cagtcactaa aagttacaag tatgattgga atacggtttg ggaatatagt accaactatc
    12841 acgaccatca gtatgcttgg attccgtcat ggtctcgtta tgacagctat tctgagtata
    12901 aagttggcgg aggctggaac tacgctcgtt atgaggtcat aaactattac agcggaggct
    12961 attaattctt aaagagtgag aaaaaggagg gctagatatg ttgcagctta ctcatgtgac
    13021 cttaaaaacg cgacaagtca tcttgcaaga tgtggatttc acctttaaaa agggtagggt
    13081 ttatggtctt cttgctatca atggctctgg aaagacgacc ctgttccgtg ccattagcaa
    13141 tttaattccc ataagtagtg gaaatatcgc agcccctcct tctttatttt attatgagag
    13201 tattgaatgg ctggatggaa acttaagtgg gatggactac cttcgtctta tcaaaaacat
    13261 ctggaagtca ggtctgaact tgagggatga aatcgcctat tgggaaatgt ctgactatat
    13321 cagtcttccc attcgcaagt attccttagg catgaagcaa cgcttggtga ttgccatgta
    13381 tttcctcagt caggccaaat gctggctcat ggatgagatt acaaatggct tagatgagta
    13441 ttatcgacag aagttttttg ataggctagc acaaatcgat agacaagaac agctggttct
    13501 tttaagttcc cactataagg aagagttggt tgatgtctgc gatagagtag taaccattca
    13561 tcaggggcag atagaagagg tttagtttat gaaagatgtt agtctatttt tattgaaaaa
    13621 agttttcaaa agccgcttaa actggattgt cttagcttta tttgtatctg tactcggtgt
    13681 taccttttat ttaaatagtc agactgcaaa ctcacacagc ttggagagca ggttggaaag
    13741 tcgcattgca gccaacgaga gggctatcaa tgaaaatgaa gagaaactct cccaaatgtc
    13801 tgataccagc tcggaggaat accagtttgc taaaaataat ttagacgtgc aaaaaaatct
    13861 tttgacgcga aagacagaaa ttctgacttt attaaaagaa gggcgctgga aagaagccta
    13921 ctatttgcag tggcaagatg aagagaagaa ttatgaattt gtatcaaatg acccgactgc
    13981 tagccctggc ttaaaaatgg gggttgaccg cgaacggaag atttaccaag ccctgtatcc
    14041 cttgaacata aaagcacata ctttggagtt tccgacccac gggattgatc agattgtctg
    14101 gattttagag gttatcatcc caagtttgtt tgtggttgct attattttta tgctaacaca
    14161 actatttgca gaaagatatc aaaatcatct ggacacagct cacttatatc ctgtttcaaa
    14221 agtgacattt gcaatatcct ctcttggagt tggagtggga tatgtaactg tgctgtttat
    14281 cggaatctgt ggcttttctt ttctagtggg aagtctgata agtggttttg gacagttaga
    14341 ttatccctac ccaatttata gcttagtgaa tcaagaagta actattggga aaatacaaga
    14401 tgtattattt cctggcttgc tcttagcttt cttagccttt atcgtcattg tggaagttgt
    14461 gtacttgatt gcttactttt tcaagcaaaa aatgcctgtc ctctttcttt cactcattgg
    14521 gattgttggc ttattgtttg gtatccaaac cattcagcct cttcaaagga ttgcacatct
    14581 gattcccttt acttacttgc gttcagtgga gattttatct ggaagattac ctaagcagat
    14641 tgataatgtc gatctaaatt ggagcatggg aatggtctta cttccttgcc tgattatctt
    14701 tttgctattg ggaattctat ttattgaaag atggggaagt tcacagaaaa aagaattttt
    14761 taatagattc tagctttcct ataggtaggg aaaataagta aaaactaaca tagagaggga
    14821 atcaacttga ttctctcttt ttgattcgaa aaccaaacca aaatacaaac acaaactttt
    14881 caaaaaataa ctttttatct tgacaagagc tagaaaactt ggtatcatat aaaagttgag
    14941 aaaagcagaa gtgagagctt ctcgccttgt gacattaagt tgcctggccc tacggatgaa
    15001 aagtttcgaa gaaacgctat cataacgtgc gggcttgtat atttacaagt ccgctattgt
    15061 ttttctctaa taaaacaaaa gaggtgaaaa ccatagcaaa gcaagactta ttcatcaatg
    15121 atgagattcg tgtacgtgaa gttcgcttga ttggtcttga aggagaacag ctaggtatca
    15181 agccactcag tgaagcgcaa gctttggctg ataacgctaa tgttgaccta gtattgattc
    15241 aaccccaagc caaaccgcct gttgcaaaaa ttatggacta cggtaagttc aaatttgagt
    15301 accagaagaa gcaaaaagaa caacgtaaaa aacaaagcgt tgttactgtg aaagaagttc
    15361 gtctaagtcc aacaattgac aagggtgact ttgatacaaa acttcgtaat gcacgtaagt
    15421 tccttgaaaa aggaaataaa gttaaggtat ctattcgctt taagggtcgt atgattaccc
    15481 ataaagagat tggtgcaaaa gttttagccg agtttgctga agcaactcaa gatattgcca
    15541 tcatcgaaca acgtgctaaa atggatggac gtcaaatgtt catgcaattg gcgccagcga
    15601 ctgacaaaaa ataattgtca gaaagttaaa taaaggagaa aaaatcatgc caaaacaaaa
    15661 aacacaccgc gcatcagcta aacgtttcaa acgtacaggt tctggtggac ttaaacgttt
    15721 ccgtgcttac acttctcacc gtttccacgg aaaaactaag aaacaacgtc gtcatcttcg
    15781 taaagcatct atggtgcatt caggagatta caaacgtatc aaagcaatgc ttactcgctt
    15841 gaaataatag cttgactgta agtaaacaat tctaggaaat atttggagga aataaaacat
    15901 ggcacgtgtt aaaggtggcg ttgtatcacg caaacgtcgt aaacgtattc ttaaattagc
    15961 aaaaggttac tatggagcta aacacatctt gttccgtact gcaaaagaac aagtaatgaa
    16021 ctcttactac tatgcatacc gtgaccgtcg tcagaaaaaa cgtgacttcc gcaaattgtg
    16081 gatcactcgt atcaatgcgg cagctcgtat gaacggactt tcatactcac aattgatgca
    16141 tggtttgaaa ttggctgaga tcgaagttaa ccgtaaaatg cttgctgact tggctgttaa
    16201 cgatgcagta gctttcacag ctcttgcaga tgcagctaaa gcaaaacttg gtaaataaca
    16261 actgatgaga ctggaacagg attgtccagt ctttttaaaa ataaaggaga aaagtatggc
    16321 ttcaaaaatg ctacacactt gcttacgagt agaaaatctt gaaaaatcaa ttgcattcta
    16381 tcaagatgct tttggtttta aagaattgcg tcgcagagat tttccagacc atgccttcac
    16441 gattgtctat ctaggtcttg agggtgatga ttatgagttg gagttgactt ataactacga
    16501 tcacggtccg tatgtggttg gtgatgggtt tgcccatatc gccctcagta cacctgatct
    16561 tgaggcactt catcaagaac acagtgcaaa aggctatgaa gtgactgagc caaatggtct
    16621 accaggaact acaccaaact attactttgt caaagaccct gatggatata aggtcgaagt
    16681 cattcgtgaa aaataatttc gtgcaagtta agtagaatat tcgttttcta cttgactttt
    16741 tttagctgaa agagtatact aataaaaatt caacctttaa ggggagtcca gagagactca
    16801 caaggtgtca gataaaagaa tagtgcaatt ttctagagga gactttttga gtgtgctctc
    16861 ttgtgttgta cgattttaac tgaggccttg cactagcaag gtcttttctt tatctggtcc
    16921 ccttaaaatt taaggaggaa aagttatgaa tcccacatgt aagaagcgtt tgggtgtcat
    16981 tcggttggaa accatgaagg tggttgcaca agaggaaatc gcgccagcaa tctttgaatt
    17041 agttctagaa ggagaaatgg ttgaagccat gcgagcaggc caatttcttc atctgcgtgt
    17101 accggacgat gcccatctct tacgtcgtcc tatttcaatt tcgtctattg acaaggcaaa
    17161 caagcagtgt cacctcattt atcggattga gggagctggg actgcaattt tttcaacctt
    17221 aagtcaggga gacactcttg atgtgatggg gcctcaggga aatggttttg acttgtctga
    17281 ccttgatgag cagaatcagg ttctccttgt tggtggtggg attggtgttc cacccttgct
    17341 tgaggtggcc aaggaattgc atggacgtgg agtgaaagta gtgacagtcc tcggttttgc
    17401 taataaggat gctgttattt tgaaaacgga attggctcag tatggtcagg tctttgtaac
    17461 gacagatgat ggttcttatg gcatcaaggg aaatgtttcc gttgttatca atgatttaga
    17521 tagtcagttt gatgctgttt actcgtgtgg ggctccagga atgatgaagt atatcaatca
    17581 aacctttgat gatcacccaa gagcctattt atctctggaa tctcgtatgg cttgtgggat
    17641 gggagcttgc tatgcctgtg ttctaaaagt accagaaagc gagacggtca gccaacgcgt
    17701 ctgtgaagat ggtcctgttt tccgcacagg aacagttgta ttataaggag aaaattatga
    17761 ctacaaatcg attacaagtg tctctacctg gtttggattt gaaaaatccg attattccag
    17821 catcaggctg ttttggcttt ggacaagagt atgccaagta ctatgattta gaccttttag
    17881 gttctattat gatcaaggcg acaacccttg aaccacgttt tgggaatcca actccaagag
    17941 tggcagagac gcctgctggt atgctcaatg caattggctt gcaaaatcct ggtttagagg
    18001 ttgttttggc tgaaaagcta ccttggctgg aaagagaata tccaaatctt cctattattg
    18061 ccaatgtagc tggtttttca aaacaagagt atgcagctgt ttctcatggg atttccaagg
    18121 caactaatgt aaaagctatc gagctcaata tttcttgtcc caatgttgac cactgtaatc
    18181 atggactttt gattggtcaa gatccagatt tggcttatga tgtggtgaaa gcagctgtgg
    18241 aagcctcaga agtgccagtt tatgtcaaat taaccccgag tgtgaccgat atcgttactg
    18301 tcgcaaaagc tgcagaagat gcgggagcaa gtggcttgac catgatcaat actctggttg
    18361 gaatgcgctt tgacctcaaa accagaaaac caatcttggc caatggaaca ggtggaatgt
    18421 caggtccagc agtctttcca gtagccctca aactcatccg ccaagtagcc caaacaacag
    18481 acctgcctat cattggaatg gggggagtgg attcggctga agctgcccta gaaatgtatc
    18541 tggctggggc atctgctatc ggagttggaa cagctaactt taccaatcct tatgcctgtc
    18601 ctgtcatcat cgaaaattta ccaaaagtca tggataaata cggtattagc agtctggaag
    18661 aactccgtca ggaagtaaaa gagtctctga ggtaaactgc aatcaatctg ttcttgattt
    18721 tttattagtt tgtaatatga atttaggaga attttggtac aataaaataa ataagaacag
    18781 aggaagaagg ttaatgaaga aagtaagatt tattttttta gctctgctat ttttcttagc
    18841 tagtccagag ggtgcaatgg ctagtgatgg tacttggcaa ggaaaacagt atctgaaaga
    18901 agatggcagt caagcagcga atgagtgggt ttttgatact cattatcaat cttggttcta
    18961 tataaaagca gatgctaact atgctgaaaa tgaatggcta aagcaaggtg acgactattt
    19021 ttacctcaaa tctggtggct atatggccaa atcagaatgg gtagaagaca agggagcctt
    19081 ttattatctt gaccaagatg gaaagatgaa aagaaatgct tgggtaggaa cttcctatgt
    19141 tggtgcaaca ggtgccaaag taatagaaga ctgggtctat gattctcaat acgatgcttg
    19201 gttttatatc aaagcagatg gacagcacgc agagaaagaa tggctccaaa ttaaagagaa
    19261 ggactattat ttcaaatccg gtggttatct actgacaagt cagtggatta atcaagctta
    19321 tgtgaatgct agtggtgcca aagtacagca aggttggctt tttgacaaac aataccaatc
    19381 ttggtttcac atcaaagaaa atggaaacta tgctgataaa gaatggattt tcgagaatgg
    19441 tcactattat tatctaaaat ccggtggcta catggcagcc aatgaatgga tttgggataa
    19501 ggaatcttgg ttttacctca agtttgatgg gaaaatagct gaaaaagaat gggtctacga
    19561 ttcttatagt caagcttggt actacttcaa atccggtggt tacatgacag ccaatgaatg
    19621 gatttgggat aaggaatctt ggttttatct caaatctgat gggaaaatag ctgaaaaaga
    19681 atgggtctac gattctcata gtcaagcttg gtactacttc aaatctggtg gttacatgac
    19741 agccaatgaa tggatttggg ataaggaatc ttggttttac ctcaagtctg atggcaaaat
    19801 ggctgaaaaa gaatgggtct acgattctca tagtcaagcc tggtactact tcaaatctgg
    19861 tggctacatg gcgaaaaatg agacagtaga tggttatcag cttggaagcg atggtaaatg
    19921 gcttggagga aaagctacaa ataaaaatgc tgcttactat caagtagtgc ctgtcacagc
    19981 caatgtttat gattcagatg gtgaaaagct ttcctatata tcgcaaggta gtgtcgtatg
    20041 gctagataag gatagaaaaa gtgatgacaa gcgcttggct attactattt ctggtttgtc
    20101 aggctatatg aaaacagaag atttacaagc gctagatgct agtaaggact ttatccctta
    20161 ttatgagagt gatggccacc gtttttatca ctatgtggct cagaatgcta gtatcccagt
    20221 agcttctcat ctttctgata tggaagtagg caagaaatat tattcggcag atggcctgca
    20281 ttttgatggt tttaagcttg agaatccctt ccttttcaaa gatttaacag aggctacaaa
    20341 ctacagtgct gaagaattgg ataaggtatt tagtttgcta aacattaaca atagcctttt
    20401 ggagaacaag ggcgctactt ttaaggaagc cgaagaacat taccatatca atgcccttta
    20461 tctccttgcc catagtgccc tagaaagtaa ctggggaaga agtaaaattg ccaaagataa
    20521 gaataatttc tttggcatta cagcctatga tacgacccct tacctttctg ccaagacatt
    20581 tgatgatgtg gataagggaa ttttaggtgc aaccaagtgg attaaggaaa attatatcga
    20641 taggggaaga actttccttg gaaacaaggc ttctggtatg aatgtggaat atgcttcaga
    20701 cccttattgg ggcgaaaaaa ttgctagtgt gatgatgaaa atcaatgaga aactaggtgg
    20761 caaagattag tactataagt gaatatgatt tgagtgaata gtaagttaaa aatcctgatt
    20821 tcaagtaaaa tcaggatttt ttcatggatg caattttttt ggagtctggt gtgacgcgga
    20881 gggtcttttg tcctgtgtaa gtgacaaagc cgggttttcc accagttggt ttattgagtt
    20941 ttttgacttc aatcatatct acctgcacca gattcgacag gcgcccttga gagaagtagg
    21001 cagctaactc tgctgcgtct gtcttgactg catcagatgg gtcaagattt cctgagatga
    21061 caacatggct tccaggaatg tccttagcat ggaaccaaag ttcctccttg cgggccattt
    21121 taaaggtcaa ttcctcattt tgaagattgt ttcgtccgac atagatgatg gttttgccat
    21181 cgcttgctag atattgttct agttttttgc gtttctggat tttctcccgt tgtcttctgc
    21241 ggataaaacc tgtttgaatc aattcttcac ggatttcagc gatttcttcc agtccagctt
    21301 ggttgaggac ggtttctaca ctttccagat agagaatagt ggctttggtt tcttcaatca
    21361 aatcagtcaa gtatttgaca gcttctttga gtttctgata ccgtttaaaa tagcgttggg
    21421 cattctggtt gggagtcaga gccttatcaa gcgcaatcat gataggttgg ttggtatagt
    21481 agttgtctag gataacctgg tcttggtcgt taggcacttg gtggaggaag gttgtcagca
    21541 attctccttt ttgacgaaat tcttcagcgt tgtctgtcgc cagtaactct ttttcctgtt
    21601 ttttgagttt gtgtcggttt ttctgaagtt cattttcaac acgacgaatc agttcactgg
    21661 cctgctgttt gacgcggtcg cgctcagcct tatccttata gtaggtgtcc aacaaatcag
    21721 aaagatttgc aaaaggctct cccacctgat ttgcaaaagg aactggactg aaggaagtct
    21781 cagtcaagca tggcttgttt tcttgattga aaaaatttcg gaaagcggaa agtttttcac
    21841 taaccagtat cctttccaat tcatttgccg tatcgcgtcc cagaccttga aagaggcttt
    21901 gaagattttt tgctgttagt tcttgggttt gcaggatttc aaagagcttt tcatccttga
    21961 tagtaaaagg attgagagat tctgtacttg gcggagcgat ataggtcgat cctggaagta
    22021 aggtgcggta gctattttgt gaaaaaccga cgtgtttgat aacttcgagg attttatgac
    22081 tgcttttatc gaccagtaga atattactgt gtttccccat aatttcaata atcaaggtag
    22141 cctggatatg gtctccaatc tcgtttttat tggaaactgt aatttccaca atacggtcat
    22201 tttccacttg ctcaatcgac tcaatcaggg ccccctgcaa atactttctc aaaaccatga
    22261 taaaggtaga aggttgagct ggattttcaa aagtcgtttg ggtcagctga atgcgtccaa
    22321 aaactggatg ggcagaaagg agcaggcgat ggctttggcg attgctgcgg atttgcaaga
    22381 ccaactcttg ttcaaaaggc tgattgattt tctggatgcg accattcact aattcgcttc
    22441 gcaattcctc aactatgtgg tgtaaaaaaa atccgtcaaa tgacatcgtt ctctccttgt
    22501 gattgtattc catagtatta tatcaaaaag gtagaataaa atcatggaaa tgtggtataa
    22561 taaagccaag taaagagaaa agagaagcac atgtatattg aaatggtaga tgaaactggt
    22621 caagtttcaa aagaaatgtt gcaacaaacc caagaaattt tggaatttgc agcccaaaaa
    22681 ttaggaaaag aagacaagga gatggcagtc acttttgtga ccaatgagcg tagtcatgaa
    22741 cttaatctgg agtaccgtaa caccgaccgt ccgacagatg tcatcagcct tgagtataaa
    22801 ccagaattgg aaattgcctt tgacgaagag gatttgcttg aaaattcaga attggcagag
    22861 atgatgtctg agtttgatgc ctatattggg gaattgttca tctctagcga taaggctcat
    22921 gagcaggccg aagaatatgg tcacagcttt gagcgtgaga tgggcttctt ggcagtacac
    22981 ggctttttac atattaacgg ctatgatcac tacactccgg aagaagaagc ggagatgttc
    23041 ggtttacaag aagaaatttt gacagcctat ggactcacaa gacaataaac gaaaatggaa
    23101 aaatcgtgac ttgatatcca gtttagaatt tgctttgaca ggtattttta ctgctatcaa
    23161 ggaagaacgc aatatgcgaa aacacgcagt gacggctcta gtggtcatcc ttgcaggttt
    23221 tggttttcag gtgtcacgaa tcgaatggct ctttctccta ttgagcattt tcttggtagt
    23281 agcctttgag attctcaact ctgctattga aaatgtggtg gatttggcca gtcactatca
    23341 cttttccatg ctggctaaaa atgccaagga tatggcggct ggcgcggtat tagtggtttc
    23401 tctttttgca gccttaacag gcgcattgat ttttctccca cgaatctggg atttattatt
    23461 ttaaacagta agaggaaatt atgactttta aatcaggctt tgtagccatt ttaggacgtc
    23521 ccaatgttgg gaagtcaact tttttaaatc acgttatggg gcaaaagatt gccatcatga
    23581 gtgacaaggc gcagacaacg cgcaataaaa tcatgggaat ttacacgact gataaggagc
    23641 aaattgtctt tatcgacaca ccagggattc acaaacctaa aacagctctc ggagatttca
    23701 tggttgagtc tgcctacagt acccttcgcg aagtggacac tgttcttttc atggtgcctg
    23761 ctgatgaagc gcgtggtaag ggggacgata tgattatcga gcgtctcaag gctgccaaga
    23821 ttcctgtgat tttggtggtg aataaaatcg ataaggttca tccagaccag ctcttgtctc
    23881 agattgatga cttccgtaat caaatggact ttaaggaaat tgttccaatc tcagcccttc
    23941 agggaaataa cgtgtctcgt ctagtggata ttttgagtga aaatctggat gaaggtttcc
    24001 aatatttccc gtctgatcaa atcacagacc atccagaacg tttcttggtt tcagaaatgc
    24061 ttcgcgagaa agtcttgcac ctaactcgtg aagagattcc gcattctgta gcagtagttg
    24121 ttgactctat gaaacgagac gaagagacag acaaggttca catccgtgca accatcatgg
    24181 tcgagcgcga tagccaaaaa gggattatca tcggtaaagg tggcgctatg cttaagaaaa
    24241 tcggtagcat ggcccgtcgt gatatcgaac tcatgctagg agacaaggtc ttcctagaaa
    24301 cctgggtcaa ggtcaagaaa aactggcgcg ataaaaagct agatttggct gactttggct
    24361 ataatgaaag agaatactaa gtagaggtag gctcatgcct gcttcttgtt tttacagaag
    24421 gaggacttat gcctgaatta cctgaggttg aaaccgtttg tcgtggctta gaaaaattga
    24481 ttataggaaa gaagatttcg agtatagaaa ttcgctaccc caagatgatt aagacggatt
    24541 tggaagagtt tcaaagggaa ttgcctagtc agattatcga gtcaatggga cgtcgtggaa
    24601 aatatttgct tttttatctg acagacaagg tcttgatttc ccatttgcgg atggagggca
    24661 agtattttta ctatccagac caaggacctg aacgcaagca tgcccatgtt ttctttcatt
    24721 ttgaagatgg tggcacgctt gtttatgagg atgttcgcaa gtttggaacc atggaactct
    24781 tggtgcctga ccttttagac gcctacttta tttctaaaaa attaggtcct gaaccaagcg
    24841 aacaagactt tgatttacag gtctttcaat ctgcccttgc caagtccaaa aagcctatca
    24901 aatcccatct cctagaccag accttggtag ctggacttgg caatatctat gtggatgagg
    24961 ttctctggcg agctcagatt catccagcta gaccttccca gactttgaca gcagaagaag
    25021 cgactgccat tcatgaccag accattgctg ttttgggcca ggctgttgaa aaaggtggct
    25081 ccaccattcg gacttatacc aatgcctttg gggaagatgg aagcatgcag gactttcatc
    25141 aggtctatga taagactggt caagaatgtg tacgctgtgg taccatcatt gagaaaattc
    25201 aactaggcgg acgtggaacc cacttttgtc caaactgtca aaggagggac tgatgggaaa
    25261 aatcatcgga atcactgggg gaattgcctc aggtaagtca actgtgacaa attttctaag
    25321 acagcaaggc tttcaagcag tggatgccga cgcagtcgtc caccaactac agaaacctgg
    25381 tggtcgtctg tttgaggctc tagtacagca ctttgggcaa gaaatcattc ttgaaaacgg
    25441 agaactcaat cgccctctcc tagctagtct catcttttca aatcctgaag agcaaaaatg
    25501 gtctaatcaa attcaagggg agattatccg tgaggaactg gctactttga gagaacagtt
    25561 ggctcagaca gaagagattt tcttcatgga tattccccta ctttttgagc aggactacag
    25621 cgattggttt gctgagactt ggttggtcta tgtggaccga gatgcccaag tagaacgctt
    25681 aatgaaaagg gaccagttgt ccaaagatga agctgagtct cgtctggcag cccagtggcc
    25741 tttagaaaaa aagaaagatt tggccagcca ggttcttgat aataatggca atcagaacca
    25801 gcttcttaat caagtgcata tccttcttga gggaggtagg caagatgaca gagattaact
    25861 ggaaggataa tctgcgtatt gcctggtttg gtaattttct gacaggagcc agtatttctt
    25921 tggttgtacc ttttatgccc atcttcgtgg aaaatctagg tgtagggagt cagcaagtcg
    25981 ctttttatgc aggcttagca atttctgtct ctgctatttc cgcggcgctc ttttctccta
    26041 tttggggtat tcttgctgac aaatacggcc gaaaacccat gatgattcgg gcaggtcttg
    26101 ctatgactat cactatggga ggcttggcct ttgtcccaaa tatctattgg ttaatctttc
    26161 ttcgtttact aaacggtgta tttgcaggtt ttgttcctaa tgcaacggca ctgatagcca
    26221 gtcaggttcc aaaggagaaa tcaggctctg ccttaggtac tttgtctaca ggcgtagttg
    26281 caggtactct aactggtccc tttattggtg gctttatcgc agaattattt ggcattcgta
    26341 cagttttctt actggttggt agttttctat ttttagctgc tattttgact atttgcttta
    26401 tcaaggaaga ttttcaacca gtagccaagg aaaaggctat tccaacaaag gaattattta
    26461 cctcggttaa atatccctat cttttgctca atctcttttt aaccagtttt gtcatccaat
    26521 tttcagctca atcgatcggc cctattttgg ctctttatgt acgcgactta gggcagacag
    26581 agaatcttct ttttgtctct ggtttgattg tgtccagtat gggcttttcc agtatgatga
    26641 gtgcaggagt catgggcaag ctaggtgaca aggtgggcaa tcatcgtctc ttggttgtcg
    26701 cccagtttta ttcagtcatc atctatctcc tctgtgccaa tgcctctagc ccccttcaac
    26761 taggactcta tcgtttcctc tttggcttgg gaaccggtgc cttgattccc ggggttaatg
    26821 ccctactcag caaaatgact cccaaagccg gcatttcgag ggtctttgcc ttcaatcagg
    26881 tattctttta tctgggaggt gttgttggtc ccatggcagg ttctgcagta gcaggtcaat
    26941 ttggctacca tgctgtcttt tatgcgacaa gcctttgtgt tgcctttagt tgtctcttta
    27001 acctgattca atttcgaaca ttattaaaag taaaggaaat ctagtgcgag taaaaattaa
    27061 tctcaaatgc tcctcttgtg acagtatcaa ttacctaacc agtaaaaatt caaaaaccca
    27121 tccagacaag attgaggttt taaagtattg tcccaaggaa agaaaagtaa ccctacatct
    27181 tgaatctaag tagattttat ggtaaaataa tagggatttt aaggagtttg atatgtataa
    27241 cctattatta accattttat tagtattatc tgttgtgatt gtgattgcaa ttttcatgca
    27301 accaaccaaa aaccaatcca gcaatgtatt tgatgccagt tcaggtgatt tgtttgaacg
    27361 cagtaaagct cgcggttttg aagctgtaat gcagcgtttg acagggattt tagtcttttt
    27421 ctggctagcc attgccttag cattgacggt attatcaagt agataagaaa ataatgggca
    27481 ggactaggtc tttgcctctt tttattttta aaggatgttt gagaaggttt tacagtaaaa
    27541 gaaaattaaa aaatctagaa agaaaatatg aaagatagaa taaaagaata tttacaagac
    27601 aagggaaagg tgactgttaa tgatttggct caggctttgg gaaaagacag ttccaaggat
    27661 tttcgtgagt tgattaaaac cttgtcctta atggaaagaa agcaccagat tcgctttgaa
    27721 gaagatggca gtctgacctt ggaagccaag aaaaaacatg agattaccct caaggggatt
    27781 tttcatgccc ataaaaatgg ttttggtttt gtcagcctag aaggggaaga ggacgacctt
    27841 tttgtaggga aaaatgatgt caactatgct attgatggtg ataccgtcga ggtagtgatt
    27901 aagaaagtcg ctgaccgcaa taagggaaca gcagcagaag ccaaaattat tgatatccta
    27961 gaacacagtt tgacaacagt tgtcgggcaa atcgttctgg atcaggaaaa gcctaagtat
    28021 gctggctata ttcgttcaaa aaatcagaaa atcagtcaac cgatttatgt taagaaacca
    28081 gccctaaagt tagaaggaac agaagttctc aaggtcttta tcgataaata cccaagcaag
    28141 aaacatgatt tctttgtcgc gagtgttctc gatgtagtgg gacactcaac ggatgtcgga
    28201 attgatgttc ttgaggtctt ggaatcaatg gacattgtat ccgagtttcc agaagctgtt
    28261 gttaaggaag cagaaagtgt gcctgatgct ccgtctcaaa aggatatgga aggtcgtctg
    28321 gatctaagag atgaaattac ctttaccatt gacggtgcgg atgccaagga cttggacgat
    28381 gcagtgcata tcaaggctct gaaaaatggc aatctggagc ttggagttca catcgcagat
    28441 gtttcttatt atgtgaccga ggggtctgcc cttgacaagg aagcccttaa ccgtgcgact
    28501 tctgtttacg tgacagaccg agtggtgcca atgcttccag aacgactatc aaatggcatc
    28561 tgctctctca atccccaagt tgaccgcctg acccagtctg ctattatgga gattgataaa
    28621 catggtcgtg tggtcaacta taccattata caaacagtta tcaagaccag ttttcgtatg
    28681 acctatagcg atgtcaatga tatcctagct ggcgatgaag aaaagagaaa agaatatcat
    28741 aaaattgtac caagtatcga actcatggcc aagcttcatg aaactttaga aaacatgcgt
    28801 gtgaaacgtg gagccctcaa ttttgatacc aatgaagcga agattttagt ggataaacaa
    28861 ggtaagcctg ttgatatcgt tcttcggcag cgtggtattg ccgagcggat gattgagtct
    28921 tttatgttga tggctaatga aacagttgcc gaacatttca gcaagttgga tttgcctttt
    28981 atctatcgaa ttcacgagga gcctaaggct gaaaaggttc agaagtttat tgattatgct
    29041 tcgagttttg gcttgcgcat ttatggaact gccagtgaga ttagtcagga ggcacttcaa
    29101 gacatcatgc gtgctgttga gggagaacct tatgcagatg tattgtccat gatgcttctt
    29161 cgctctatgc agcaggctcg ttattcggag cacaatcacg gccactatgg actagctgct
    29221 gactattata ctcactttac cagtccaatt cgtcgttatc cagaccttct tgttcaccgt
    29281 atgattcggg attacggccg ttctaaggaa atagcagagc attttgaaca agtgattcca
    29341 gagattgcga cccagtcttc caaccgtgaa cgtcgtgcca tagaagctga gcgtgaagtc
    29401 gaagccatga aaaaggctga gtatatggaa gaatacgtgg gtgaagagta tgatgcagtt
    29461 gtatcaagta ttgtcaaatt cggtctcttt gtcgaattgc caaacacagt tgaaggcttg
    29521 attcacatca ctaatctacc tgaattttat catttcaatg agcgtgattt gactcttcgt
    29581 ggagaaaaat caggtatcac tttccgagtg ggtcagcaga tccgtatccg tgttgaaaga
    29641 gcggataaaa tgactggaga gattgatttt tcattcgtac ctagtgagtt tgatgtgatt
    29701 gaaaaaggct tgaaacagtc tagtcatagt ggcagagggc gtggttcaaa tcgtcgttcg
    29761 gataagaagg aagacaagag aaaatcagga cgctcaaatg ataagcgtaa gcattcacaa
    29821 aaagacaaga agaaaaaagg aaagaaacct ttttacaagg aagtagctaa gaaaggagcc
    29881 aagcatggca aagggcgagg gaaaggtcgt cgcacaaaat aaaaaggcac gccacgacta
    29941 tacaatcgta gatacgctag aggcagggat ggtcctgact ggaactgaaa tcaagagtgt
    30001 acgagctgct cgaattaatc tcaaggatgg ctttgctcaa gtgaaaaatg gagaagtttg
    30061 gctgagcaat gttcatatcg cgccttacga agagggcaat atctggaacc aggaaccaga
    30121 acgtcgtcgt aaactcctgc tccataaaag gcaaattcaa aaattggaac aagagaccaa
    30181 agggacagga atgaccttag ttccccttaa ggtctatata aaagatggct acgctaagct
    30241 tcttttagga cttgccaaag ggaagcatga ctatgacaaa cgggagtcta tcaaacgtcg
    30301 tgagcaaaat cgagatatcg cgcgtgtgat gaaagctgtt aatcagcgat aaaaagagga
    30361 attgaaaatg gaaaaattag ttgcctataa acgcatgcct ttgtggaata aacaaacaat
    30421 gcctgaagct gttcagcaaa agcacaatac aaaagttggg acttggggga aaattactgt
    30481 cttgaaggga gctctcaagt ttattgaatt gacagaagaa ggggaagttc tagctgaaca
    30541 cctctttgaa gcaggggcag acaatccaat ggcccaacct caagcctggc accgagtgga
    30601 agctgccaca gatgatgtgg aatggtactt ggaattttat tgtaaacctg aggattattt
    30661 tgctaaaaaa tacaatacca atcctgttca ttcagaggtc ctagaggcca tggagacagt
    30721 gaaacaaggg aaagctttgg atttgggttg tggtcagggg cgtaattctc tttttctagc
    30781 ccagcaagat tttgatgtga cggctgtaga tcaaaatgga ctagctcttg aaatcttgca
    30841 aagcattgtg gagcaggaag atttggacat gcctgttggc ctttacgata tcaattcagc
    30901 tagcattgaa caagaatatg attttatcgt ttcaacagtt gttctcatgt ttctacaagc
    30961 ggaccgcatt ccagctatta ttcaaaatat gcaggagaaa accagtgttg gtggttacaa
    31021 ccttatcgtt tgtgccatgg acacggagga ttatccttgc tcggttaact tcccattcac
    31081 ctttaaagaa ggagaactgg cagactatta caaggattgg gaattggtta agtacaatga
    31141 aaatccaggc catttgcatc gtcgcgatga gaatggcaat cgtattcaac tacgctttgc
    31201 gaccttacta gctaagaaaa tcaagtaaac acacatgaag attaggaatt ttcctgatct
    31261 tttttctttt ttacgaatga tatagaaaag gagggaattc atgtttgttg cgagagatgc
    31321 taggggagaa ttggtaaatg tgttagagga taaacttgag aagcaagcat acacctgccc
    31381 agcttgtgga ggccagctcc atttgcgtca aggaccaagt gtacggacgc attttgccca
    31441 taaatcctta aaagactgtg attttttctt tgaaaatgaa agtccagaac acctggccaa
    31501 taaggaatcc ctctatcact ggttgaaaaa agagacaaag gttcaattag agtacccgct
    31561 ttcagaactt aaacagattg cggatgtatt tgtaaatggc aatctagctc tagaagttca
    31621 gtgtagtccc ttgcctcaga aagtccttaa agagcgaagt gagggctatc gtagtcaggg
    31681 ttaccaagta ctgtggttgc tgggtcaaaa actgtggctc aaggagcgtt tgactcgtct
    31741 acagcaaggt tttctttatt tcagtcaaaa catgggcttt tatgtttggg aattagacaa
    31801 ggaaaaacaa gttttaagac tcaaatacct gatttaccag gatctccgcg gtaaactcca
    31861 ttatcaaatc aaggaatttt cctatggtca aggtagttta ttggaaatat tgcgtcttcc
    31921 ctataagaga caaaaaatat ctcattttac agtttctgag gacaaggaca tctgtcgcta
    31981 tatccagcaa caactttatt atcaaaatct cttttggatg aaagaacaag cagaagccta
    32041 tcaaaaggga gaaaatatcc tgacttatgg actgaaagaa tggtatccac aaattcgacc
    32101 aatagtgggc aaatttttcc agattgaaca agacttgact agctattatc agcactttta
    32161 tacctattac caaaaaaatc ctcaaaatga ttggcaaaag ctttatccac cagcctttta
    32221 tcagcaatat ttcttgaaaa atatggtaga atagaaagga tggaggaatc taatggtatt
    32281 acaaagaaat gaaataaatg aaaaagatac atgggatcta tcaacgatct acccaactga
    32341 ccaggcttgg gaagaagcct taaaagattt aacagaacaa ttggagacag tagcccagta
    32401 tgaaggccat ctcttggata gtgcggataa cctactagaa atcactgaat tttctcttga
    32461 aatggaacgc cagatggaga agctttacgt ttatgctcat atgaagaatg accaggatac
    32521 acgtgaagct aagtatcaag agtactatgc caaggccatg acactctaca gccagttaga
    32581 ccaagccttt tcattctatg atcctgaatt tatggagatt agcgaaaagc agtatgctga
    32641 ctttttagaa gctcaaccaa agctgcaggt ttatcaacac tattttgaca agctcttgca
    32701 aggcaaggat cacgttcttt cacaacgtga agaagaatta ttggctggag ctggagaaat
    32761 ctttggttca gcaagtgaaa ccttcgctat cttggacaat gcggatattg tgttccctta
    32821 tgtcctagac gatgatggta aagaagttca gctatctcat gggacttaca cacgtttgat
    32881 ggagtctaaa aaacgtgagg ttcgccgtgg tgcctatcaa gctctttatg cgacttacga
    32941 acaattccaa cacacctatg ccaaaacctt gcaaaccaat gttaaggtgc aaaattaccg
    33001 tgctaaagtt cgtaactaca agagtgctcg tcatgcagcc ctcgcagcga attttgttcc
    33061 agaaagtgtt tatgacaatt tggtagcagc agttcgcaag catttgccac tcttacatcg
    33121 ctatcttgag cttcgttcaa aaatcttggg gatttcagat ctcaagatgt acgatgtcta
    33181 cacaccgctt tcatctgttg aatacaattt tacctaccaa gaagccttga aaaaagcaga
    33241 agatgctttg gcagtcttgg gtgaggatta cttgagccgt gtcaaacgtg ccttcagcga
    33301 gcgttggatt gatgtttacg aaaatcaagg caagcgttca ggtgcctact ctggtggttc
    33361 ttacgatacc aatgccttta tgcttctcaa ctggcaggac aatctggaca atctctttac
    33421 tcttgttcat gaaacaggtc acagtatgca ttcaagctat actcgtgaaa ctcagcctta
    33481 tgtttacgga gattactcta tctttttggc tgagattgcc tcaactacca atgaaaatat
    33541 cttgacggag aaattattgg aagaagtgga agacgacgca acacgctttg ctattctcaa
    33601 taacttccta gatggtttcc gtggaacagt tttccgccaa actcaatttg ctgagtttga
    33661 acacgccatt caccaagcag atcaaaatgg ggaggtcttg acaagcgatt tcctaaataa
    33721 actctacgca gacttgaacc aagagtatta tggtttgagt aaggaagaca atcctgaaat
    33781 ccaatacgag tgggctcgca ttccacactt ctactataac tactatgtat atcaatattc
    33841 aactggcttt gcggccgcct cagccttggc tgaaaaaatt gtccatggta gtcaagaaga
    33901 ccgtgaccgc tatatcgact acctcaaggc aggtaagtcg gactatccac ttaatgtcat
    33961 gagaaaagct ggtgttgata tggagaagga agactacctc aacgatgcct ttgcagtctt
    34021 tgaacgccgt ttaaatgagt ttgaagccct tgttgaaaaa ttaggattgg cataaaatgg
    34081 ttgaatcgta tagtaagaat gctaaccata acatgcgtcg tcctgtcgtc aaagaagaaa
    34141 ttgtagactt gatgcgtcag cgtcaaaagc aggtcacagg tttcttgaaa gaattggaag
    34201 aatttgcccg caaggaaaat attcctatta ttccccatga aacggttgct tatttccgtt
    34261 ttcttatgga aaccatgcag cctaaaaata ttctggaaat tgggacggct atcggttttt
    34321 cagctctctt gatggctgaa catgcgccaa atgctaagat tacaactatt gatcgtaatc
    34381 cagaaatgat tggttttgcc aaggaaaatt ttgcccagtt tgacagtcgc aagcaaatca
    34441 ctctcctaga gggagatgcg gtggatgtct tatctacact gacagagtct tatgatttcg
    34501 tctttatgga ttctgccaag tctaaataca tcgtctttct gccagaaatc ctcaaacatt
    34561 tggaagttgg tggtgtggtt gtcttggatg atatttttca aggtggtgat gttgccaagg
    34621 atattatgga agtccgtcgt ggtcagcgaa ccatttatcg aggccttcaa aaattatttg
    34681 atgcaacctt agacaatcca gaactcaccg caacattagt gcctttagga gatggtattc
    34741 tcatgcttcg taaaaatgta gcagatgttc aactgtctga aagcgaatga ttttcagaaa
    34801 aatttaagaa aaaatagtaa aatagataga gtaacactta tctcaaagga gtagacatga
    34861 agaaaaaatt attggcaggt gccatcacac tattatcagt agcaacttta gcagcttgtt
    34921 cgaaagggtc agaaggagca gaccttatca gcatgaaagg ggatgtcatc acagaacatc
    34981 aattttatga gcaagtgaaa aacaaccctt cagcccaaca agtcttgtta aatatgacca
    35041 tccaaaaagt ttttgaaaaa caatatggct cagagcttga tgataaagag gttgatgata
    35101 ctattgccga agaaaaaaaa caatatggcg aaaactacca acgtgtcttg tcacaagcag
    35161 gtatgactct tgaaacacgt aaagctcaaa ttcgtacaag taaattagtt gagttggcag
    35221 ttaagaaggt agcagaagct gaattgacag atgaagccta taagaaagcc tttgatgagt
    35281 acactccaga tgtaacggct caaatcatcc gtcttaataa tgaagataag gccaaagaag
    35341 ttctcgaaaa agccaaggca gaaggtgctg attttgctca attagccaaa gataattcaa
    35401 ctgatgaaaa aacaaaagaa aatggtggag aaattacctt tgattctgct tcaacagaag
    35461 tacctgagca agtcaaaaaa gccgctttcg ctttagatgt ggatggtgtt tctgatgtga
    35521 ttacagcaac tggcacacaa gcctacagta gccaatatta cattgtaaaa ctcactaaga
    35581 aaacagaaaa atcatctaat attgatgact acaaagaaaa attaaaaact gttatcttga
    35641 ctcaaaaaca aaatgattca acatttgttc aaagcattat cggaaaagaa ttgcaagcag
    35701 ccaatatcaa ggttaaggac caagccttcc aaaatatctt tacccaatat atcggtggtg
    35761 gagattcaag ctcaagcagt agtacatcaa acgaatagtc caaatcaatg agtcagggaa
    35821 aaaaactcga cttcaggaaa aaatgaagca aacattccca aaataaaacg catagtacaa
    35881 ggtttgtact gcccccaaaa gttagacaat taatttatct gaaggattta gttctgtatt
    35941 gcacagggct aagtcctttt agttttacct taattctctt attgttgtaa taatcaata
//
LOCUS       DBMVGT010000014        32658 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.014, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000014 DBMVGT010000000
VERSION     DBMVGT010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 32658)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32658)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32658
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.014"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..136
                     /locus_tag="AC0DU4_000745"
     CDS             <1..136
                     /locus_tag="AC0DU4_000745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HIN4236741.1"
                     /translation="FKNKAFQTLEDVMNQLQDVIQGLEKEVIKSIVNRRWTRMLFESR
                     "
     gene            complement(159..509)
                     /gene="tnpB"
                     /locus_tag="AC0DU4_000746"
     CDS             complement(159..509)
                     /gene="tnpB"
                     /locus_tag="AC0DU4_000746"
                     /inference="COORDINATES: protein motif:HMM:NF017528.6"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HIN4236742.1"
                     /translation="MTIHLSSLGQVYLVCGKTDMRQGIDSLAYLVKTHFELDPFSGQV
                     FLFCGGRKDRFKALYWDGQGFWLLYKRFENGRLTWPSTEKDVKALTPEQVDWLMKGFS
                     ITPKINLSESRDFY"
     gene            complement(490..675)
                     /locus_tag="AC0DU4_000747"
     CDS             complement(490..675)
                     /locus_tag="AC0DU4_000747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136123.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236743.1"
                     /translation="MPQPIVPVEIPQSRPFDSKKRNDILLKIRIGKLEVSFFQSLNLE
                     MVEQLLDKVLLYDNSSI"
     gene            complement(979..2541)
                     /gene="guaA"
                     /locus_tag="AC0DU4_000748"
     CDS             complement(979..2541)
                     /gene="guaA"
                     /locus_tag="AC0DU4_000748"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003922 - GMP synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016462 - pyrophosphatase activity
                     [Evidence IEA];
                     GO_process: GO:0006177 - GMP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HIN4236744.1"
                     /translation="MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHK
                     ISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGG
                     KVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSAD
                     CPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKK
                     IRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLG
                     GKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGT
                     LYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHI
                     VWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVR
                     SVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYD
                     ITSKPPATVEWE"
     gene            2683..3381
                     /locus_tag="AC0DU4_000749"
     CDS             2683..3381
                     /locus_tag="AC0DU4_000749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000936186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HIN4236745.1"
                     /translation="MLPAYMKIHDQIKKDIDEHRWAIGERLPSERDLAEQFAVSRMTL
                     RQAVSLLVEEGVLERRVGSGTFVSSTRVQEKMRGTTSFTEIVKSQGKVPSSQLISYKK
                     TIPNEQEVAKLGIFPTDNIIRMERVRYADQVPLVYEVASIPEKFIKDFKKEEITSHFF
                     QTLQKHGYRIGKSQQTIYARLAKEKIAHYLEVEKGHAILGLTQISYLEDGTAFEYVKS
                     QYVGERFEFYLENN"
     gene            complement(3424..4320)
                     /locus_tag="AC0DU4_000750"
     CDS             complement(3424..4320)
                     /locus_tag="AC0DU4_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HIN4236746.1"
                     /translation="MSNSLKGTLLTVVAGIAWGLSGTSGQYLMAHGISALVLTNLRLL
                     IAGGILMLLAYATAKDKILVFLKDRKSLLSLLIFALIGLFLNQFAYLSAIQETNAGTA
                     TVLQYVCPVGILIYSCIKDRVAPTLGEIVSIIFAIGGTFLIATHGQLDQLSMTPAGLF
                     WGLFSALTYALYIILHIALIKKWGSSLVIGVGMVIAGLVALPFTGVLQADIPTSLDFL
                     LAFAGIILIGTVFAYTAFLKGASLIGPVKSSLLASIEPISAIFFAFLIMNEQFYPIDF
                     LGMAMILFAVTLISLKDLFLEK"
     gene            complement(4329..5264)
                     /locus_tag="AC0DU4_000751"
     CDS             complement(4329..5264)
                     /locus_tag="AC0DU4_000751"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="HIN4236747.1"
                     /translation="MKWTKIIKKIEEQIEAGIYPGASFAYFKDNQWTEFYLGQSAPEH
                     GLQTEAGLVYDLASVSKVVGVGTVCTFLWEIGQLDIDRLVIDFLPESDYPDITIRQLL
                     THATDLDPFIPNRDLLTAPELKEAMFHLNRRSQPAFLYSDVHFLLLGFILERIFNQDL
                     DVILKDQVWKPWGMTETKFGPVELAVPTVRGVEAGIVHDPKARFLGRHAGSAGLFSTI
                     KDLQIFLEHYLADDFARDLNQNFSPLDDKERSLAWNLEGDWLDHTGYTGTFIMWNRQK
                     QEATIFLSNRTYEKDERAQWILDRNQVMNLIRKEE"
     gene            complement(5261..5986)
                     /locus_tag="AC0DU4_000752"
     CDS             complement(5261..5986)
                     /locus_tag="AC0DU4_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001102210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CppA family protein"
                     /protein_id="HIN4236748.1"
                     /translation="MNVNQIVRIIPTLKANNRKLNETFYIETLGMKALLEESAFLSLG
                     DQTGLEKLVLEEAPSMRTRKVEGRKKLARLIVKVENPLEIEGILSKTDSIHRLYKGQN
                     GYAFEIFSPEDDLILIHAEDDRASLVEVGEKPEFQTDLASISLSKFEISMELHLPTDI
                     ESFLESSEIGASLDFIPAQGQDLTVDNTVTWDLSMLKFLVNELDIASLRQKFESTEYF
                     IPKSEKFFLGKDRNNVELWFEEV"
     gene            complement(6070..6705)
                     /locus_tag="AC0DU4_000753"
     CDS             complement(6070..6705)
                     /locus_tag="AC0DU4_000753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="HIN4236749.1"
                     /translation="MAVQLLENWLLKEQEKIQTKYRHLNHISVVEPNILFIGDSIVEY
                     YPLQELFGTSKTIVNRGIRGYQTGLLLENLDAHLYGGAVDKIFLLIGTNDIGKDVPVN
                     EALNNLEAIIQSVARDYPLTEIKLLSILPVNEGEKYQQAVYIRSNEKIQNWNQAYQEL
                     ASAYMQVEFVPVFDCLTDQAGQLKKEYTTDGLHLSIAGYQALSKALKDYLY"
     gene            complement(6707..7534)
                     /locus_tag="AC0DU4_000754"
     CDS             complement(6707..7534)
                     /locus_tag="AC0DU4_000754"
                     /EC_number="3.-.-.-"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HIN4236750.1"
                     /translation="MMIKVIATDMDGTLLDARGQLDLPRLEKILDQLDQRGIRFVIAT
                     GNEIHRMRQLLSPLVDRVVLVVANGARIFENNELIQAQTWDDAIVNKALAHFKGRACQ
                     DQFVVTGMKGDFVKEGTIFTDLESFMTPEMIEKFYQRMQFVDELTSDLFGGVLKMSMV
                     VGEERLSSVLEEINALFDGRVRAVSSGYGCIDILQAGIHKAWGLEELLKRWDLKSQEI
                     MAFGDSENDVEMLEMAGIAYAMENADEKAKAVATALAPANSQGGVYQVLENWLEKGE"
     gene            complement(7556..7891)
                     /locus_tag="AC0DU4_000755"
     CDS             complement(7556..7891)
                     /locus_tag="AC0DU4_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="poly-gamma-glutamate biosynthesis protein"
                     /protein_id="HIN4236751.1"
                     /translation="MGNFISNQRIESMGDEENAKWTERGVLMDVTIKKKDGKTTIGTA
                     KAHPTWVNRTPKGTFSPEGYPLYHYQTYILEDFIEDGSHRDQLDEATKERIDTAYKEM
                     NEHVGLKWY"
     gene            complement(7892..8482)
                     /locus_tag="AC0DU4_000756"
     CDS             complement(7892..8482)
                     /locus_tag="AC0DU4_000756"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: protein motif:HMM:NF021127.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
                     /protein_id="HIN4236752.1"
                     /translation="MGDFEGTINKDHYLAGYLLFNAPAEVMDAIKEAGYHVLDLAHNH
                     ILDSQIEGVISTADIIEKAGITPIGVYTHEPRDQAPLVIKEVNGIKVALLAYSYGFNG
                     IEQYISQEDYNRYLSDLNEDKMKVEIERAEKEADITIIMLQMGVEYRLELTEEQKALY
                     HKMIDWGADIIFGGHPHVVEPSETVEKDGDKKLIIY"
     gene            complement(8498..8620)
                     /locus_tag="AC0DU4_000757"
     CDS             complement(8498..8620)
                     /locus_tag="AC0DU4_000757"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236753.1"
                     /translation="MAHGDLLYHDGLFFSAKKEDGTYDFHENFEYVTPWLKQGD"
     gene            9133..9744
                     /gene="def"
                     /locus_tag="AC0DU4_000758"
     CDS             9133..9744
                     /gene="def"
                     /locus_tag="AC0DU4_000758"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042586 - peptide deformylase activity
                     [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HIN4236754.1"
                     /translation="MSAIERITKAAHLIDMNDIIREGNPTLRAIAEEVTFPLSDQEII
                     LGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEA
                     YDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHR
                     IKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE"
     gene            9789..10517
                     /gene="rlmB"
                     /locus_tag="AC0DU4_000759"
     CDS             9789..10517
                     /gene="rlmB"
                     /locus_tag="AC0DU4_000759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HIN4236755.1"
                     /translation="MKTNDIVYGVHAVTEALLANTGNKLYLQEDLRGKNVEKVKELAT
                     EKKVSISWTSKKSLSEMTEGAVHQGFVLRVSEFAYSELDYILAKTRQEENPLLLILDG
                     LTDPHNLGSILRTADATNVSGVIIPKHRAVGVTPVVAKTATGAIEHVPIARVTNLSQT
                     LDKLKDEGFWTFGTDMNGTPCHKWNTKGKIALIIGNEGKGISSNIKKQVDEMITIPMN
                     GHVQSLNASVAAAILMYEVFLNRL"
     gene            complement(10556..11467)
                     /gene="trxB"
                     /locus_tag="AC0DU4_000760"
     CDS             complement(10556..11467)
                     /gene="trxB"
                     /locus_tag="AC0DU4_000760"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004791 - thioredoxin-disulfide reductase
                     (NADPH) activity [Evidence IEA];
                     GO_function: GO:0071949 - FAD binding [Evidence IEA];
                     GO_process: GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HIN4236756.1"
                     /translation="MYDTIIIGAGPAGMTAALYAARSNLKVALIEGGLPGGQMNNTSD
                     IENYPGYANISGPELAEKMFEPLENLGVEHIYGYVENVEDHGDFKKVMTDDQTYETRT
                     VIVATGSKHRPLGVPGEEELNSRGVSYCAVCDGAFFRDQDLLVVGGGDSAVEEALFLT
                     RFAKTVTIVHRRDQLRAQKVLQDRAFANEKISFIWDSVVKEIKGENRVESVVFENVKT
                     GQVTEQAFGGVFIYVGLDPLSDFVKELNIQDQAGWIVTDSHMKTAVDGIFAVGDVRLK
                     DLRQVTTAVGDGAIAGQEAYKFITEHS"
     gene            complement(11533..11757)
                     /locus_tag="AC0DU4_000761"
     CDS             complement(11533..11757)
                     /locus_tag="AC0DU4_000761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4059 family protein"
                     /protein_id="HIN4236757.1"
                     /translation="MLLQLFSLYFESLILTTILVLIFLGIWIGLRAMSGVDKTAGARQ
                     AHLYDMIMIGVLVVPVLSFAVMSLILVFKA"
     gene            complement(11835..12578)
                     /locus_tag="AC0DU4_000762"
     CDS             complement(11835..12578)
                     /locus_tag="AC0DU4_000762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015424 - ABC-type amino acid transporter
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HIN4236758.1"
                     /translation="MIKISNLSKSFSGQTVLDHLNLDIQKGEVVALIGSSGAGKSTFL
                     RSLNYLETPDSGSIQIDGFSVDFSKITQEEILALRRKLSMVFQQFNLFERRTALDNVK
                     EGLVVVKKLSDQEATKIAKEELAKVGLSDRENHYPRHLSGGQKQRVALARALAMKPDV
                     LLLDEPTSALDPELVGEVEKSIADAAKSGQTMILVSHDMSFVAQVADKILFLDKGKII
                     ESGTPDEIIHTPKEERTKEFFASYKRTYI"
     gene            complement(12578..13378)
                     /locus_tag="AC0DU4_000763"
     CDS             complement(12578..13378)
                     /locus_tag="AC0DU4_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001103446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HIN4236759.1"
                     /translation="MNVTTILASDWYQNLMQLIPDGKLFSLRSVFDGIPRIVQQLPTT
                     IMLTIGGALFGLVLALLFAIVKINRVKILYPLQAFFVSFLKGTPILVQLMLTYYGIPL
                     ALKALNQQWGTGLNINAIPAAAFAIVAFAFNEAAYASETIRAAILSVNPGEIEAARSL
                     GMTRAQVYRRVIIPNAAVVATPTLINSLIGLTKGTSLAFSAGVVEVFAQAQILGGADY
                     RYFERFISVALVYWVVNIGIESLGRFIERKMAISAPDTVQTDVKGDLR"
     gene            complement(13536..13892)
                     /locus_tag="AC0DU4_000764"
     CDS             complement(13536..13892)
                     /locus_tag="AC0DU4_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HIN4236760.1"
                     /translation="MLEFIEYPKCSTCKKAKQELNQLSVDYKAVHIVEETPSQEVILN
                     WLETSGFELKQFFNTSGIKYRELGLKDKVGSLSNQEAAELLASDGMLLKRPILVENGT
                     VKQIGYRKSYEELGLK"
     gene            complement(13905..14417)
                     /locus_tag="AC0DU4_000765"
     CDS             complement(13905..14417)
                     /locus_tag="AC0DU4_000765"
                     /EC_number="2.1.1.63"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001170346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003908 -
                     methylated-DNA-[protein]-cysteine S-methyltransferase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HIN4236761.1"
                     /translation="MQKKYVKILYSSPIGILSLVADDHYLYGIWVQEQKHFERGLGDE
                     TIEEVVSHPILDPVIACLDDYFKGKPQDLSNLLLAPIGTNFEKRVWDYLQGIPYGQTV
                     TYGQIAQDLQVASAQAIGGAVGRNPWSILVPCHRVLGAGKRLTGYAAGVEKKAWLLEH
                     EGVDFKDINK"
     gene            complement(14417..14911)
                     /locus_tag="AC0DU4_000766"
     CDS             complement(14417..14911)
                     /locus_tag="AC0DU4_000766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase family protein"
                     /protein_id="HIN4236762.1"
                     /translation="MEIRLAFPNEVDAIMQVMEDAKKCLADAGSDQWQNGYPNADVII
                     DDIISGQAYVALEEGELLAYAAVTKSPEEAYEAIYEGNWQAGESEYLVFHRIAVAADV
                     QGKGVAQTFLEGLIEGFDYLDFRSDTHAENKVMQHIFEKLGFKQVGKVPVDGERLAYQ
                     KLKK"
     gene            15046..15492
                     /locus_tag="AC0DU4_000767"
     CDS             15046..15492
                     /locus_tag="AC0DU4_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HIN4236763.1"
                     /translation="MKTTFSYPKWAEIPNIDLYLDQVLLYVNQVCAPISPNKDKGLTA
                     SMINNYVKNGYLTKPDKKKYQRQQIARLIAITTLKSVFSIQEIAQTLNTLQTQASSDQ
                     LYDAFVDYMNQGIDPANPIIQTSCQTVKLYHQTLDLIDHTQEEVIQ"
     gene            15489..16136
                     /gene="trhA"
                     /locus_tag="AC0DU4_000768"
     CDS             15489..16136
                     /gene="trhA"
                     /locus_tag="AC0DU4_000768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001097995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PAQR family membrane homeostasis protein TrhA"
                     /protein_id="HIN4236764.1"
                     /translation="MNTSLKLSKQLSFGEEIANSVTHAVGAVIMLILLPISSIYSYEA
                     HGFLSSIGVSIFVISLFLMFLSSTIYHSMAYGSTHKYVLRIIDHSMIYVAIAGSYTPV
                     VLTLMNNWFGYLIIVIQWGTTIFGILYKIFAKNVNEKFSLALYLIMGWLVLAIIPAII
                     SQTTPVFWSLMVTGGLCYTVGAGFYAKKKPYFHMIWHLFILAASVLQYIAIVYYM"
     gene            complement(16157..16738)
                     /gene="pdxT"
                     /locus_tag="AC0DU4_000769"
     CDS             complement(16157..16738)
                     /gene="pdxT"
                     /locus_tag="AC0DU4_000769"
                     /EC_number="3.5.1.2"
                     /EC_number="4.3.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004359 - glutaminase activity [Evidence
                     IEA];
                     GO_function: GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA];
                     GO_process: GO:0042823 - pyridoxal phosphate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase glutaminase
                     subunit PdxT"
                     /protein_id="HIN4236765.1"
                     /translation="MKIGILALQGAFAEHAKVLDQLGVESVELRNLDDFQQDQSDLSG
                     LILPGGESTTMGKLLRDQNMLLLIREAILSGLPVFGTCAGLILLAKEITSQKESYLGT
                     MDMVVERNAYGRQLGSFYTEAECKGVGKIPMTFIRGPIISSVGEGVEILATVNNQIVA
                     AQEKNMLVSSFHPELTDDVRLHQYFINMCKEKS"
     gene            complement(16739..17614)
                     /gene="pdxS"
                     /locus_tag="AC0DU4_000770"
     CDS             complement(16739..17614)
                     /gene="pdxS"
                     /locus_tag="AC0DU4_000770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000138516.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0042819 - vitamin B6 biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0042823 - pyridoxal phosphate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase lyase subunit
                     PdxS"
                     /protein_id="HIN4236766.1"
                     /translation="MTENRYELNKNLAQMLKGGVIMDVQNPEQARIAEAAGAAAVMAL
                     ERIPADIRAAGGVSRMSDPKMIKEIQEAVSIPVMAKVRIGHFVEAQILEAIEIDYIDE
                     SEVLSPADDRFHVDKKEFQVPFVCGAKDLGEALRRIAEGASMIRTKGEPGTGDIVQAV
                     RHMRMMNQEIRRIQNLREDELYVAAKDLQVPVELVQYVHEHGKLPVVNFAAGGVATPA
                     DAALMMQLGAEGVFVGSGIFKSGDPVKRASAIVKAVTNFRNPQILAQISEDLGEAMVG
                     INENEIQILMAERGK"
     gene            complement(17766..19145)
                     /gene="nox"
                     /locus_tag="AC0DU4_000771"
     CDS             complement(17766..19145)
                     /gene="nox"
                     /locus_tag="AC0DU4_000771"
                     /EC_number="1.6.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="H2O-forming NADH oxidase"
                     /protein_id="HIN4236767.1"
                     /translation="MSKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGC
                     GMALWIGEQIDGAEGLFYSDKEKLEAKGAKVYMNSPVLSIDYDNKVVTAEVEGKEHKE
                     SYEKLIFATGSTPILPPIEGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQ
                     HLDRIAVVGGGYIGVELAEAFERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHN
                     IRLALGQTVKAIEGDGKVERLITDKESFDVDMVILAVGFRPNTALADGKIELFRNGAF
                     LVDKKQETSIPGVYAVGDCATVYDNARKDTSYIALASNAVRTGIVGAYNACGHELEGI
                     GVQGSNGISIYGLHMVSTGLTLEKAKAAGYNATETGFNDLQKPEFMKHDNHEVAIKIV
                     FDKDSREILGAQMVSHDIAISMGIHMFSLAIQEHVTIDKLALTDLFFLPHFNKPYNYI
                     TMAALTAEK"
     gene            19439..20362
                     /locus_tag="AC0DU4_000772"
     CDS             19439..20362
                     /locus_tag="AC0DU4_000772"
                     /EC_number="2.7.1.180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0017013 - protein flavinylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HIN4236768.1"
                     /translation="MTLRSHSERLMGTTITISLVDEQADIFLQKSFDLLKELEYRFNA
                     NSQESELMEINYQAGISPVTVHPDLFELISLGLEHSLALSSHLNISIGPLIQTWRIGF
                     SDAKVAQPQEIESVLPLINPHGIELDSSTSTVFLKQKGMKIDLGCLAKGYSADKVAQF
                     LRKEGVTSALINLGGNILTIGKNQARGDNPWQIGIQDPANPRGNHLMTIPVVNKSVVT
                     SGIYERHLTVDGQDYHHIFDSQTGYPVETELASLTIISDKSVDGEIWTTRLFGERPAS
                     IFWQVESLEGIEVILIDKEGHLSCSSGIPTL"
     gene            20422..21027
                     /locus_tag="AC0DU4_000773"
     CDS             20422..21027
                     /locus_tag="AC0DU4_000773"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008752 - FMN reductase [NAD(P)H] activity
                     [Evidence IEA];
                     GO_function: GO:0008753 - NADPH dehydrogenase (quinone)
                     activity [Evidence IEA];
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050136 - NADH:ubiquinone reductase
                     (non-electrogenic) activity [Evidence IEA];
                     GO_function: GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="HIN4236769.1"
                     /translation="MLKLIAIVGTNSKRSTNRQLLQYMQKHFADKAEIELVEIKAIPV
                     FNKPADKQVPAEILEIAAKIEEADGVIIGTPEYDHSIPAVLMSALAWLSYGIYPLLNK
                     PIMITGASYGTLGSSRAQLQLRQILNAPEIKANVLPDEFLLSHSLQAFNPSGDLVDLD
                     VIKKLDAIFDDFRIFVKITEKLRNAQELLRKDAEDFDWENL"
     gene            21046..22290
                     /locus_tag="AC0DU4_000774"
     CDS             21046..22290
                     /locus_tag="AC0DU4_000774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000673688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HIN4236770.1"
                     /translation="MKFVGLVGSNYDQSYNRKLLEFIRRYFKLKFELEVLEIDEVPMF
                     NQDEKWDESFQLRYLYNKITRADGVIIATPEHNHTISASLKSVLEWLSYEVHPFENKP
                     VMIVGASYYDQGTSRAQVHLRKILDAPGVNAYTLPGNEFLLGKAKEAFDNNGNITNEG
                     TVKFLETCLDNFVKYVGVVSKLKKPKPIESEDLDCGKPIATTITEVDPDDPEWVEKVA
                     AITGAVSGDTYVKLDHGILTVNQIDMFLKAMPFELTYADDNNQFLYYNNAHQDPDTMF
                     AKRVPPQSGSRMSTVHGSLPPARMKNVEWVIGTLRNGNQEYVRTIVPGSPAGVINTHN
                     YQAMYYPDGSYAGINEIVFNFQPWLDWYLKETGQRLVGGSGPFAPAAGGHGDADATSG
                     ASDSGDAGGHGGDADATAGASY"
     gene            complement(22406..22663)
                     /locus_tag="AC0DU4_000775"
     CDS             complement(22406..22663)
                     /locus_tag="AC0DU4_000775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002901318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 family protein"
                     /protein_id="HIN4236771.1"
                     /translation="MDPKKIARINELAKKKKTEGLTPEEKVEQAKLREEYIEGYRRAV
                     RHHIEGIKIVDEEGNDVTPEKLRQVQREKGLHGRSLDDPNS"
     gene            complement(22705..24741)
                     /gene="glyS"
                     /locus_tag="AC0DU4_000776"
     CDS             complement(22705..24741)
                     /gene="glyS"
                     /locus_tag="AC0DU4_000776"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004820 - glycine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006426 - glycyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HIN4236772.1"
                     /translation="MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKENRLSFEAI
                     QTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKEIALDSDGNFTKAAQGFVRGKGLTVE
                     DIEFREIKGEEYVYVTKEEVGQAVEAIVPGVVDVLKSLTFPVSMHWAGNSFEYIRPVH
                     TLTVLLDEQEFDLDFLDIKGGRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCER
                     EQMIVDQIKKIEAKHGVRIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEVPEEVLVTS
                     MKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQ
                     KLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKAGLSVDETVDLARAAAIY
                     KFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAV
                     LAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYA
                     LKFDSLTYENKAEVMDFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEV
                     SKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQ
                     LKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK"
     gene            complement(24953..25870)
                     /gene="glyQ"
                     /locus_tag="AC0DU4_000777"
     CDS             complement(24953..25870)
                     /gene="glyQ"
                     /locus_tag="AC0DU4_000777"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018163989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004820 - glycine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006426 - glycyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HIN4236773.1"
                     /translation="MSKKLTFQEIILTLQQFWNDQGCMLMQAYDNEKGAGTMSPYTFL
                     RAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLEK
                     LGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATGPVTAE
                     VTYGLERLASYIQEVDSVYDIEWADGVKYGEIFIQPEYEHSKYSFEISDQEMLLENFD
                     KFEKEAGRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVA
                     KTFVAERKRLGYPLLDEETRAKLLAEDAE"
     gene            complement(26238..26999)
                     /locus_tag="AC0DU4_000778"
     CDS             complement(26238..26999)
                     /locus_tag="AC0DU4_000778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HIN4236774.1"
                     /translation="MDNLYLVKDDSQLATFRDFVVRNTEKLKDYQSFLKNELAVCDLP
                     QAVIWSDFNAATQIIRESAVPAYTNNRRMVMAPDLAVWKELYLYQLMDYECSEQTQAI
                     ESHYHSLSENFLLQIVGHELAHWSEHFLDDFDGYDSYIWFEEGMVEYISRKYFFTEEE
                     FQAEKICNQSLVELFQKKYGWHSLNDFGSSTYDKNYASIFYEYWRSFLTVDKLVENLG
                     SVQAVLDSYHLWANTEKTFPLLDWFVQQKLIEKEI"
     gene            complement(27272..28114)
                     /locus_tag="AC0DU4_000779"
     CDS             complement(27272..28114)
                     /locus_tag="AC0DU4_000779"
                     /EC_number="1.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HIN4236775.1"
                     /translation="MNTYQLNNGVEIPVLGFGTFKAKDGEEAYHAVLEALKAGYRHID
                     TAAIYQNEESVGQAIKDSGVPREEMFVTTKLWNSQQTYEQTRQALEKSIEKLGLDYLD
                     LYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETA
                     TIVPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKS
                     IAQIALAWSLAEGFLPLPKSVTTSRIQANLDCFGIELSHEERETLKTIAVQSGAPRVD
                     DVDF"
     gene            complement(28228..29619)
                     /gene="pgdA"
                     /locus_tag="AC0DU4_000780"
     CDS             complement(28228..29619)
                     /gene="pgdA"
                     /locus_tag="AC0DU4_000780"
                     /EC_number="3.5.1.104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050119 - N-acetylglucosamine deacetylase
                     activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0042545 - cell wall modification [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan-N-acetylglucosamine deacetylase
                     PgdA"
                     /protein_id="HIN4236776.1"
                     /translation="MNKSRLGRGRHGKTRHVLLALIGILAISICLLGGFIAFKIYQQK
                     SFEQKIESLKKEKDDQLSEGNQKEHFRQGQAEVIAYYPLQGEKVISSVRELINQDVKD
                     KLESKDNLVFYYTEQEESGLKGVVNRNVTKQIYDLVAFKVEETEKTSLGKVHLTEDGQ
                     PFTLDQLFSDASKAKEQLIKELTSFIEDKKIEQDQSEQIVKSFSDQDLSAWNFDYKDS
                     QIILYSSPVLENLEEIALPVSAFFDVIQSSYLLEKDAALYQSYFDKKYQKVVALTFDD
                     GPNPATTPQVLETLAKYDIKATFFVLGKNVSGNEDLVKRIKSEGHVVGNHSWSHPILS
                     QLSLDEAKKQITDTEDVLTKVLGSSSKLMRPPYGAITDDIRNSLDLSFIMWDVDSLDW
                     KSKNEASILTEIQHQVANGSIVLMHDIHSPTVNALPRVIEYLKNQGYTFVTIPEMLNT
                     RLKAHELYYSRDE"
     gene            complement(29857..30292)
                     /locus_tag="AC0DU4_000781"
                     /pseudo
     CDS             complement(29857..30292)
                     /locus_tag="AC0DU4_000781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000603324.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
     gene            30464..31441
                     /locus_tag="AC0DU4_000782"
     CDS             30464..31441
                     /locus_tag="AC0DU4_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="HIN4236777.1"
                     /translation="MLKLGVIGTGAISHHFIEAAHTSGEYQLVAIYSRKLETAATFAS
                     RYQNIQLFDQLEVFFKSSFDLVYIASPNSLHFAQAKAALSAGKHVILEKPAVTQPQEW
                     FDLIQTAEKNNCFIFEAARNYHEKAFTTIKNFLADKQVLGADFNYSKYSSKMPDLLAG
                     QTPNVFSDRFAGGALMDLGIYPLYAAVRLFGKANDATYHAQQLDNSIDLNGDGTLFYP
                     DYQVHIKAGKNITSNLPCEIYTTDGTLTLNTIEHIRSAIFTDHQGNQVQLPIQQDPHT
                     MTEEVAAFAHMIQQPDLNLYQTWLYDAGSVHELLYTMRQTAGIRFEAEK"
     gene            31438..32520
                     /locus_tag="AC0DU4_000783"
     CDS             31438..32520
                     /locus_tag="AC0DU4_000783"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HIN4236778.1"
                     /translation="MKTKLPTEWQELSDQLGFQEFTLIQTQLFEPLLAGENLLGVSQT
                     GTGKTLAYLLPSLLRLQKKKAQQLLILAPNTELAGQIFDVCKTWAEAIGLTAQLFLSG
                     SSQKRQIERLKKGSEILIGTPGRIFELIKLKKIKMMNVETIILDEFDQLLDDSQIHFV
                     EKITHYAPRDHQLVYMSATTKFDQEKIVPNTRTIDLSDQKLDNIQHFYMQVDQRHRVD
                     MLRKLAHVEDFRGLVFFNSLSDLGNAEEKLQYRDILAVSLASDVNVKFRKIILEKFKD
                     NQLTLLLATDLLARGIDIDSLECVVNFDIPRDSETYTHRAGRTGRMGKEGYVITLVTH
                     PEEIKKLKKFASIREIVLKNQELYIK"
BASE COUNT         9692 a         7323 c         5874 g         9769 t
ORIGIN      
        1 atttaagaat aaagcctttc aaactttgga agatgtcatg aatcaacttc aagatgttat
       61 acaaggactg gagaaggagg tgataaagtc catcgttaat cggagatgga ctagaatgct
      121 ttttgaaagc agatgagtat aaaaagaaag tcctcatttc aatagaaatc acgactttct
      181 gataaattta ttttgggagt gatagaaaag cccttcataa gccaatctac ttgttcaggt
      241 gtgagagctt tgacatcctt ttctgtactg ggccaagtca gtctgccgtt ctcaaagcgt
      301 ttatatagta gccaaaatcc ttgaccatcc cagtaaaggg ctttaaagcg gtctttacgt
      361 ccaccacaaa agagaaaaac ttgaccggag aaaggatcca attcaaagtg ggttttaacc
      421 agataagcca gtgaatcgat tccttgtctc atatcagtct tcccacacac gagatagacc
      481 tgccctaggc tagatagatg aattgtcata gagcaacacc ttatccaaaa gctgttctac
      541 catttcgaga ttgagagatt gaaaaaaact tacttcaagc ttgccaatac gaattttaag
      601 cagaatatca tttctctttt tagaatcaaa aggacgagat tgtggaatct ctacaggaac
      661 aataggttgt ggcattaaaa tatcctccaa tagttttact ttactaatag tatacaggag
      721 gaactccatg aatgatagat accttgttat gacgcgctta ctatattaga aagttggctc
      781 tctaattaaa ttaattctca ttatatatat caaaagaccg cagtttgaaa actacggtct
      841 aattttttgt ccaaatgtaa atcacttgga actattattc aatttattct ttttagtaaa
      901 tgttcccgtt ttaatcccag ttacagtttt taatcctctg taaccgttga ttttacaaag
      961 cttttaattt ttttgcgatt actcccactc aactgttgca ggtggtttac ttgtaatatc
     1021 gtagacgata cggttaacat gatccacttc atttacgata cgtactgaga ttttttgaag
     1081 tacttcccat ggaattttgg caaaatcagc agtcatacca tcgatagaag tgatagcacg
     1141 gattgcaatc gtgtagtcat acgtacgacc gtcacccata acaccgactg aacgaacgcc
     1201 tgtgttaaca gtgaagtatt gccaaatatc gcggtcaagt ccagctttag cgatttcttc
     1261 acgaagaata gcgtctgatt cacgaacggt ttcaagtttc tcttcagtga tttcacccat
     1321 gacacggata gcaagtcctg gtcctgggaa tggttggcgc catacgatat ggtctggcat
     1381 accaagctct gtaccaagag cacgaacttc atccttgtaa agagtattga gtggttcaat
     1441 caattcaaac tgcatatctt ctggaagacc acccacgttg tggtgtgact tgatagtttg
     1501 agctgtatcc gtaccagact cgataacatc tgtatataaa gtaccttgag caaggaattt
     1561 cacatctttg agcttgcttg cttcgtcatc gaatacatag acaaactcgt taccaatgat
     1621 tttacgtttt tgttcaggat cagaaacgcc agcaagtttg tcaaggaaac gtttagcagc
     1681 gtctgctttg acgatattca aaccaaactt accaccgagc atgtccataa cttgatcagc
     1741 ttcgccttta cgaagaagac cgtggtctac gaagatacag atcaattgat cgccaatcgc
     1801 tttttggaga agaaccccaa cgacagatga gtcaacacca cctgatagac caagaaggac
     1861 acgtttatca ccgacggttt cacgaatttt tttgatctgc atgtcaatga aattatccat
     1921 tgaccagtca cctttagcct tacaaatgtt aagggcaaag ttacgaagga tatcatttcc
     1981 gtatacagaa tgacgaactt ctgggtggaa ttggataccg taaatgtgtt tatctgggtt
     2041 ttcgatggct gcgtatgggc agtcagctga tgtacctgta cgaacaaagt cagcaggaat
     2101 ctcagtaacc gcatcaccat ggctcatcaa aacagtctgt tcatcaggtg ttgattcaaa
     2161 aagcgctgat ggtgtgtgag ttagggttga ttgaccgtat tcacgatttc cagcatcacc
     2221 tgcaggaaca acttttcctc caagtttatg ggtcaataac tgcataccat aacagattcc
     2281 caaaattgga attccgagtt cgaagatttc tgggtcaata tcaaatgaac catcttcata
     2341 tacagaattt ggaccacctg atagaataat tcctacagga ttgacttcac gaacttcagc
     2401 agctgaaatt ttatggcttt ttagttctga aaaaacacca atctcacgga tacggcgtga
     2461 aatcagctgg ttgtactggc taccatagtc caatacgatg attttttcta catcttgcaa
     2521 atcagttgaa atgttgctca tctttttcct ttctcaaaag aaatatcttt tctcaatatt
     2581 ctatcacaaa taagggcgaa ttaccaacta aacaaggcga agtttgactt tttctagttt
     2641 attggggtac aatagagaaa agatagaaat gaagtgaaaa atatgctacc tgcttatatg
     2701 aaaatccatg atcagataaa aaaggatatt gacgagcacc gttgggctat tggtgagagg
     2761 cttcccagtg aaagagattt agctgagcag tttgcggtca gtcgcatgac cctccgccaa
     2821 gccgtatctc tattagtcga agaaggcgtc ttagagcgcc gtgtaggaag cggcaccttt
     2881 gtttccagta ctcgagtaca agaaaagatg cgagggacaa ccagttttac tgaaattgtc
     2941 aaatcccaag gtaaagttcc ctctagccag ctcatttcct acaaaaaaac cattcccaat
     3001 gagcaagaag ttgccaagct aggaattttt ccaacggaca atattatccg aatggagcgg
     3061 gtccgctatg ccgaccaagt tcccctagtt tatgaagttg cttctattcc tgaaaaattc
     3121 attaaggact ttaaaaaaga agaaatcacc agtcatttct tccaaacctt gcaaaaacat
     3181 ggctatcgta tcggtaaatc ccaacagacc atctatgctc gccttgctaa agaaaagatt
     3241 gcccactatt tggaagttga aaaaggacat gctattcttg gattgaccca gatttcctac
     3301 ctagaagatg gtactgcttt tgaatacgta aaaagtcaat atgtaggcga acgctttgaa
     3361 ttttatcttg aaaataatta gattaccacg caaaaactct ctgtcacgga caaagagtct
     3421 tttttatttt tctaagaata aatctttcaa agaaatcaaa gttacagcaa acaatatcat
     3481 tgccatacca agaaaatcaa tgggataaaa ttgttcattc attattaaga aggcaaagaa
     3541 aatcgccgat attggctcaa ttgaagccaa caagcttgac ttgaccggtc ctatcagact
     3601 ggctccttta aggaaagctg tataggcaaa gacagtcccg ataaggataa tgcctgcaaa
     3661 cgcaaggaga aaatcaagac tagtcgggat atcggcctgt agaacccctg taaaaggaag
     3721 ggcgaccaaa cctgctatga ccattcccac accaatgacc aagctgctcc cccacttttt
     3781 aatcaaggct atgtgtaaaa tgatatacaa agcataagtc aaggcagaaa agagacccca
     3841 gaacagacca gcaggtgtca tggataactg gtccaactgc ccatgtgttg cgatcaggaa
     3901 ggttcctccg atggcgaata tgatggaaac tatctctccc agtgtcggtg ccaccctatc
     3961 cttgatacag ctataaatta aaattccgac aggacaaaca tactgaagca ccgtcgctgt
     4021 tcccgcattg gtctcctgaa tagcagacag ataggcgaat tggttgagaa aaagaccaat
     4081 cagagcaaaa ataagaagag acagcaaact ctttctatcc tttaaaaaga ccagtatttt
     4141 atcctttgca gtagcataag ccaagagcat gagaattcca ccagcgatta aaagacgcaa
     4201 gttagtcaag accagagccg aaattccgtg tgccattagg tattggccac tcgttcctga
     4261 caacccccaa gcaataccag ccacaactgt tagtaaagtc ccttttaaac tatttgacat
     4321 gtctctcctt actcttcttt gcgaatcaag ttcatcactt gattgcggtc taatatccat
     4381 tgagctctct cgtccttttc ataggtacga ttcgatagga aaatagtggc ttcttgcttc
     4441 tgacgattcc acatgataaa ggtacctgta tagcccgtat ggtctagcca atctccttcc
     4501 aaattccatg ctaaagaacg ttccttgtca tccaaaggag aaaaattttg atttaagtct
     4561 cttgcaaaat catctgctaa atagtgttct aaaaagattt gtaaatcctt tatagtcgaa
     4621 aataaaccag cactcccagc atgtctaccc aggaaacgag ccttgggatc atgcactatg
     4681 cctgcctcta cacctctaac tgttggaaca gcaagctcaa ctggcccaaa cttagtttcc
     4741 gtcattcccc aaggtttcca gacttgatcc tttaaaatca catccaaatc ttgattaaaa
     4801 attctttcca aaataaagcc caacagcaaa aaatggacat ccgaataaag aaaggctggc
     4861 tgacttcgtc tgttgagatg aaacatcgct tcctttaatt caggggctgt taaaagatca
     4921 cgattaggaa taaaaggatc aaggtctgtt gcatgagtca agagctggcg aatagtgatg
     4981 tctggataat cactctcagg taaaaaatct attaccagtc tatcaatatc taattgacct
     5041 atttcccaca agaaggtaca aactgtgcca accccaacaa ccttgctgac actagctagg
     5101 tcataaacta gtcctgcctc agtctgcaag ccatgctctg gggcactctg gcctaaatag
     5161 aactctgtcc attgattgtc cttaaaatac gcaaaagagg ctccgggata aattcctgcc
     5221 tcgatttgtt cttctatttt tttaataatc ttggtccact tcatacttct tcaaaccaca
     5281 attcaacatt atttctatct ttaccaagga agaatttttc agacttagga ataaaatatt
     5341 cagtagactc aaacttctgg cgaagacttg ctatgtctaa ttcattgacc aagaacttga
     5401 gcatagataa gtcccaggta accgtattgt ccacagtcaa atcctgcccc tgagctggaa
     5461 taaaatcaag ggatgcccca atttcagatg attccaagaa actttcgata tcagttggga
     5521 gatgtaattc catagaaatc tcaaatttac ttaaagaaat tgatgccaaa tctgtttgaa
     5581 attcaggctt ttctcctact tctactagac ttgctctgtc atcttccgca tgaatcaaaa
     5641 tcaaatcatc ttctggtgag aaaatttcaa aagcgtagcc attttgacct ttatataatc
     5701 gatgaatcga atctgtttta gataagattc cttcaatttc taagggattt tccaccttga
     5761 caatcaatct agctagtttt tttcttccct ctaccttacg agtacgcata ctgggagctt
     5821 cttctaaaac cagcttttca agacccgttt ggtcacctag tgacagaaag gccgattctt
     5881 ctaacagggc cttcattcca agggtttcaa tataaaatgt ttcatttaat tttctattat
     5941 tagcttttaa agtaggaata atccgtacaa tctgatttac attcataaat tcctccgtca
     6001 ctttttattt taaaggattt tagaattttt tacaagatat tatgctcaaa tttaacatta
     6061 tttagctatt tagtaaagat agtctttcaa ggcttttgac aaagcctgat aaccagcaat
     6121 actgaggtgc agtccatcag ttgtatattc ttttttgagt tggcctgctt ggtctgtcaa
     6181 acaatcaaat actggcacaa attccacctg catataggca gatgcaagct cttgataggc
     6241 ttgattccaa ttctgaattt tttcattcga gcggatatag actgcctgct ggtacttctc
     6301 tccctcattg acaggcaaaa tggaaagcaa tttaatctct gtcaatggat aatcgcgagc
     6361 aacggattga atgatagctt cgagattatt gagagcctca ttcacaggaa catcctttcc
     6421 gatatcattt gtcccaatca gaagaaaaat tttatctact gctccaccat atagatgagc
     6481 atcaaggttc tctagtaaca gtcctgtctg atagccacga attcctcgat tgacaatcgt
     6541 ctttgaagtc ccaaatagct cctgtagagg ataatactcg acaatggaat ccccaataaa
     6601 aagaatgttt ggttctacaa cagaaatgtg atttaggtga cgatatttgg tttgaatttt
     6661 ttcttgttcc tttaggagcc aattttctaa taactgtact gccacttcat tctccttttt
     6721 ctaaccagtt ttccaagact tgataaactc ctccttggct gttggctggt gctagagcag
     6781 tcgccacagc tttggctttc tcatcagcat tttccatcgc ataggcaatt ccagccattt
     6841 caagcatttc aacatcattt tcactatcac caaaagccat gatttcttgg gatttcaagt
     6901 cccagcgctt gagtaattcc tccaagcccc atgctttatg aatcccagct tggaggatat
     6961 caatgcaacc atagccactg gatacagctc ggacacggcc atcaaagaga gcattgattt
     7021 cttccaaaac cgaactcaaa cgttcctcac caacaaccat gctcatcttg agcacaccac
     7081 caaagaggtc agatgttaat tcatccacaa attgcatccg ttggtagaat ttttcaatca
     7141 tttctggagt cataaaactt tcaagatctg taaaaatcgt accttccttg acaaaatcac
     7201 ccttcatccc cgttacaaca aactggtcct gacacgctcg acccttgaaa tgagccaaag
     7261 ccttgttgac aatggcgtca tcccatgtct gagcctgaat caattcattg ttttcaaaaa
     7321 tacgagcgcc attagcaaca accagaacca ctcgatccac caagggactc agtagttgtc
     7381 tcatgcggtg aatttcattg cccgtcgcaa tgacaaaacg aatgcccctt tgatccaact
     7441 gatctaaaat cttttccaat cgtgggagat caagctgacc tctagcatcc agcaaggtcc
     7501 catccatatc tgtcgcaatt accttaatca tcatttactt tcctctggat tcaagctaat
     7561 accacttcaa tcccacatgt tcattcattt ctttataggc tgtatcaatt cgttccttag
     7621 tcgcttcatc taactggtca cgatgactgc catcctctat aaaatcttcc aaaatataag
     7681 tttggtaatg atacaaggga tatccttctg gtgaaaaggt tccctttggt gttcgattga
     7741 cccaagtagg atgagcttta gctgttccga tagttgtttt tccatccttc ttcttgatgg
     7801 tgacatccat gagaacacca cgttcagtcc acttagcatt ctcttcatct cccatagatt
     7861 caatccgttg attggaaatg aagttcccca tttaatagat aatgagtttc ttatctccat
     7921 ctttttcaac cgtttcagat ggttcaacaa cgtgaggatg ccctccaaag ataatatccg
     7981 ctccccaatc gatcatcttg tgataaagag ctttttgttc ttcagttagt tccaatcgat
     8041 actcaacacc catctgaagc atgataatgg tgatatctgc ttccttctct gcccgttcaa
     8101 tttcaacctt catcttatct tcgtttaaat ctgaaagata acgattatag tcttcctgag
     8161 aaatatactg ctcaattcca ttgaaaccat aggaataggc taacaatgca accttgatac
     8221 cattcacttc cttaatgacc agcggagcct gatcacgtgg ttcgtgcgta taaactccga
     8281 ttggagtgat tccagctttc tcaataatat cggccgttga aataactccc tcaatttgcg
     8341 aatccaaaat atgattatga gctaaatcca gcacatgata acctgcctcc ttaatagcat
     8401 ccataacttc agcaggagca ttaaagagaa gataacccgc taaataatga tccttattaa
     8461 tggttccttc aaaatcacca atagctaaat ctgctgctta gtccccttgc ttgagccaag
     8521 gagtcacata ctcaaaattt tcatgaaagt cataggtacc gtcttctttt ttagctgaaa
     8581 agaaaagtcc atcgtggtag agcaaatccc cgtgggccat aattctggca gttttttcct
     8641 cttcctactc ctgagacttt tgcttagtcc cctcttgaga aatagtatct cgtttttgac
     8701 tagtcaaggg attccttgga agctttcaaa caacaagacc aagcccattg ataaatcaac
     8761 tgctagcaag agtatcgcca caaatccctt attgctccac ttgcgataac tcctaaaaag
     8821 tttaccaagc ccttcataaa acgaaaagct aaaccaccct gatttcgatt ttgtcttctt
     8881 tgtatcttca ttctccctac tttcttatgc aagccttttc tttttattat atcacagata
     8941 agtatttctt tcacaattga attgaacttc ccatctattt tctataaatc ctaaatgcca
     9001 taatgctttc aattcttgtc attttgtgat atcatgtaga ggaaatgaac taatccacag
     9061 tggcttattc caagtatacc acttgggctt tggcagtagc taactgcact aaacataata
     9121 taaggagaga aaatgtctgc aatagaacgt attacaaaag ctgctcactt aattgatatg
     9181 aacgatatta tccgtgaagg gaatcctact ctacgcgcga ttgctgagga agtcactttc
     9241 cccctatctg accaggaaat catcctaggc gaaaagatga tgcaattcct taaacattcc
     9301 caagatcctg tcatggctga aaaaatggga ctccgcggtg gtgttggact ggctgctccc
     9361 cagttagata tctcaaaacg cattatcgct gttttggtac ctaatattgt tgaagaaggc
     9421 gaaactccac aggaagccta cgatttggaa gccattatgt acaatccaaa aatcgtctct
     9481 cactctgttc aagatgctgc tcttggcgaa ggagaaggtt gcctgtctgt tgaccgtaac
     9541 gtgcctggct atgttgttcg ccatgcccgc gttactgttg actactttga caaagatgga
     9601 gaaaaacacc gtatcaaact caaaggctac aactccattg ttgttcagca tgaaattgac
     9661 cacattaacg gtatcatgtt ttacgatcgc atcaatgaaa aagacccatt tgcagttaaa
     9721 gatggtttac tgattcttga ataaagaaaa tcccgttgca agacggggtt ttgtgttata
     9781 atagaggcat gaaaacaaat gatattgtct atggcgtcca cgccgttacc gaagccctcc
     9841 ttgcaaatac aggaaacaaa ctctacctcc aagaagatct ccgaggtaag aatgttgaga
     9901 aagtcaagga actagctaca gaaaagaagg tgtccatttc ttggacatca aaaaaatctc
     9961 tctctgagat gactgaaggt gctgttcatc aaggttttgt tctacgagtg tctgaatttg
    10021 cctatagcga gctagattac atccttgcaa aaacacgcca agaagaaaat ccacttctat
    10081 tgattctaga tggtctaacc gatccccata atctgggttc tatcttgcga acagccgatg
    10141 cgaccaatgt ttcaggtgtc atcattccca agcaccgtgc tgtcggagta actcctgtcg
    10201 ttgccaaaac agccacaggt gctattgaac acgttccaat tgcccgagtg accaacctca
    10261 gtcaaacctt agataaactc aaggatgaag gcttctggac ctttggaacg gatatgaacg
    10321 gtactccttg ccacaagtgg aatacaaaag ggaaaatcgc cctcatcatc ggaaatgaag
    10381 gaaaaggcat ctctagcaac atcaaaaaac aggtcgatga aatgattacc attccgatga
    10441 atggacatgt tcaaagcctc aatgccagtg ttgctgcagc cattctcatg tacgaagttt
    10501 ttctaaatag actataaaaa agtttccagt catctgattg gaaacttttt tatgattaac
    10561 tatgttctgt gataaacttg taggcttctt gaccagcgat agctccatct ccaactgctg
    10621 ttgttacttg gcgaaggtct ttcaagcgaa catctccaac tgcaaagata ccgtcgactg
    10681 cagtcttcat gtggctatct gtcacaatcc agcctgcctg atcttggata ttcaattctt
    10741 taacaaaatc gctaagaggg tccaaaccaa catagataaa gacaccaccg aaggcttgct
    10801 ctgtcacttg acctgttttc acattttcaa aaacgacaga ttctactctg ttttcaccct
    10861 tgatttcctt cactacagaa tcccagataa agctgatttt ttcattcgca aaggcgcgat
    10921 cttgtaaaac cttttgggca cgaagttggt cacgacggtg aacaatggta acagtcttag
    10981 caaaacgagt caagaagagg gcttcttcaa cagctgaatc tccaccacca actaccaata
    11041 aatcttggtc acggaagaaa gcaccatcac acacagcaca gtaagaaaca ccacgactgt
    11101 tcagttcttc ttctccaggc actcccaaag gacggtgttt agaaccagtt gctacgataa
    11161 ctgtacgtgt ttcatatgtt tggtcatcag tcatcacttt cttaaaatca ccatggtctt
    11221 cgacattttc aacataacca taaatgtgct caacaccaag attttcaagt ggttcaaaca
    11281 tcttttcagc caattcaggt ccactaatat tagcatatcc tgggtaattt tcgatatcag
    11341 atgtattatt catctgacca cctggcagac caccttcaat caaagctact tttagattgc
    11401 ttcgagcagc atacaaggcc gcagtcatcc ctgcaggtcc agcaccgata ataatagtat
    11461 cgtacatata gattccttct ttcttgttgt aactatcttt attctaactc tttcttgtca
    11521 atcacgcaag gattatgcct tgaaaacaag aattaaactc ataaccgcaa aggataatac
    11581 tgggacaacc aagactccaa tcataatcat atcatagaga tgggcttggc gagccccggc
    11641 tgtcttatca actcccgaca tggctctcag accaatccaa atccctaaaa aaatcagaac
    11701 aaggatggtg gtcaagatca aactctcgaa atataaagaa aatagttgca gtagcatgat
    11761 ttctctcatt tctatctttt ttaaagagta aactcagcta gtccaactaa ctgagttttc
    11821 ctttatctat tatatcaaat ataagtccgt ttgtaactag caaagaattc ttttgtccgc
    11881 tcttctttag gggtgtggat aatctcatcc ggagttccag actcgatgat tttcccctta
    11941 tctaagaaga gaattttatc cgcaacttgg gctacaaagg acatgtcatg actgaccaaa
    12001 atcatggtct gacctgactt agcagcatct gcaatagact tttctacttc accgaccaat
    12061 tctgggtcaa gggctgaagt tggttcgtct aagagcaaaa catctggttt catagcaagc
    12121 gcacgcgcta gggcaacccg ttgcttctgt ccacctgata aatggcgagg ataatggttt
    12181 tcacggtccg aaagcccaac cttagccaac tcttccttgg caatcttagt cgcttcttgg
    12241 tcagataatt tcttgacaac aaccaagcct tctttcacat tatcaagtgc tgttcggcgt
    12301 tcaaataaat taaactgttg gaaaaccata gacaacttac ggcgtagggc aaggatttct
    12361 tcttgagtga ttttagaaaa atcaactgaa aaaccatcaa tctgaataga gccactgtca
    12421 ggtgtttcaa gataattgag actgcgaaga aaggttgatt ttccagctcc tgaagaacca
    12481 atcaaggcta caacttcccc tttttgaata tccaagttca gatgatccaa gacagtctgt
    12541 cctgaaaagg atttgcttaa attcgaaatc ttaatcatta acgaaggtct cctttcacat
    12601 ctgtttgcac tgtatcaggt gcagaaatag ccatttttct ctcgatgaaa cgaccgaggc
    12661 tttcaattcc gatattgact acccaataaa caagggcaac ggagatgaag cgttcaaaat
    12721 agcgataatc agctccacct agaatctgag cttgggcaaa gacttccaca acacccgcac
    12781 taaaagctag agatgttccc ttggtcaaac cgatgaggga attaatcaag gttggagtag
    12841 ctaccaccgc tgcattagga ataatcactc gtcgataaac ttgcgctcgg gtcataccca
    12901 gactgcgcgc cgcctcaatc tcaccaggat taactgagag aatggctgca cgaatggttt
    12961 cactagcata agctgcctca ttaaaggcaa aagcgacaat cgcaaaagct gcagctggaa
    13021 tcgcattgat attgagacca gttccccatt gctgattgag ggctttcaaa gccaaaggga
    13081 ttccgtagta ggtcaacatg agttgcacca aaatcggtgt cccttttaag aaactaacaa
    13141 agaaggcctg caagggatat aaaatcttga cacgattgat cttcacaatg gcaaaaagaa
    13201 gcgccaaaac caagccaaaa agggcaccac caattgtcaa cataattgtt gttggaagtt
    13261 gttggacaat tctagggatt ccatcaaaga ccgaacgtag gctaaacagc ttgccatccg
    13321 gaatcaattg catcaagttt tggtaccaat ctgatgctaa aatcgttgta acattcataa
    13381 aaacatcctc ttctgataat gattcattct accatgcttc tgccgtcaat gaaattattt
    13441 gctacggtca gatacagact ttgtctacct actagtttat catactttga aacagggaag
    13501 ttatatattt tatctatcaa agagatagat aaaaactatt tcagtcccag ttcttcataa
    13561 gattttcgat aaccgatttg cttaacagtt ccattttcta ctaaaatggg ccgttttaac
    13621 aacataccgt cacttgctag caactcagcc gcttcttggt ttgacaaact tcctacctta
    13681 tcttttagcc ctaattcacg gtatttgata ccactggtgt tgaaaaattg cttcaattca
    13741 aatcctgagg tttctagcca attcaaaatg acttcttggc taggtgtttc ttccacgata
    13801 tggacggctt tataatccac acttaattga tttaattctt gttttgcttt tttacaagtt
    13861 gaacatttgg ggtattcgat aaattctaac atgtgcttct ccttctattt gtttatatct
    13921 ttaaaatcta cgccttcatg ctccaagagc caagctttct tttccactcc tgcagcatag
    13981 cctgtcagac gcttgcctgc tcccaacaca cgatgacaag gtactaggat agaccaagga
    14041 ttgcgtccca ctgctccacc aattgcttga gcagaagcca cttgcaggtc ttgagcaatt
    14101 tgtccatagg tcactgtctg accataagga atgccctgta aatagtccca aactctcttt
    14161 tcaaaattcg ttccgattgg cgccaagagc aagttggata aatcctgagg cttgccttta
    14221 aagtaatcat ctaagcaagc aataactggg tctaaaatag gatgactaac aacttcttct
    14281 atcgtttcat ctcctagtcc cctctcaaaa tgcttctgct cctgaaccca aattccatac
    14341 aaataatggt catcagctac aagtgataga ataccaattg gtgaggagta gagtattttt
    14401 acatacttct tttgcattat ttctttaatt tttgataggc caagcgttcg ccatctactg
    14461 gcaccttacc aacttgttta aaaccaagtt tttcaaaaat atgttgcata accttgtttt
    14521 cagcatgcgt atctgagcga aaatcaagat aatcaaaacc ttcaatcaag ccctctaaga
    14581 aggtttgagc aactcctttt ccctgcacat ctgctgccac agcaatacgg tgaaagacta
    14641 gatactctga ctctccagct tgccagtttc cctcataaat agcttcatag gcctcctctg
    14701 gactcttggt cacagcagca taggctagca gttctccctc ttccaaggct acgtaggctt
    14761 gccctgagat gatatcatcg ataataacat ctgcatttgg atagccattt tgccactggt
    14821 cactaccagc atctgctaaa cattttttgg catcctccat cacctgcatg atggcatcta
    14881 cttcatttgg aaaagctaaa cgaatttcca tcttttttcc tcatttctga ctagtttctc
    14941 ccatcatagc ataatttaag tatttctaca agcagttaaa acttgacttt gtgtttttgt
    15001 tattttataa tctagttatc aaaactatat aaaaaggagt tgaaaatgaa aactaccttt
    15061 tcctacccaa aatgggcaga aattccaaac attgacctct atctggacca ggttttgctc
    15121 tatgtcaatc aggtctgcgc ccctatctct cctaataaag acaagggcct aacagcatct
    15181 atgatcaaca attatgtgaa aaatggttac ctgacaaagc ctgacaaaaa aaaataccaa
    15241 cgccaacaga ttgcccgttt gattgctatc acaaccctca agtctgtatt ttctattcaa
    15301 gaaatagccc agacacttaa tactctacaa actcaagcaa gttcagacca actctacgat
    15361 gcttttgtgg actacatgaa ccaaggaatt gacccagcta accctattat ccaaaccagc
    15421 tgccaaaccg ttaaactcta tcatcaaact ctagacttaa tcgatcatac tcaagaggag
    15481 gtaatccaat gaacactagt cttaaactca gcaaacaact cagttttgga gaggagattg
    15541 ctaatagcgt gacccatgct gtgggtgcag tcatcatgct tatcttgctg cctatttcat
    15601 ccatctatag ttatgaagca cacggatttt tatcctctat cggcgtttcc attttcgtca
    15661 tcagtctctt tctcatgttc ctatcatcca ccatttatca ctctatggcc tatggttcga
    15721 cccacaaata tgttttgcga atcattgacc attctatgat ttacgttgcc attgccggct
    15781 catacacgcc cgttgtcttg accttgatga ataactggtt tggctatctg attattgtca
    15841 tccaatgggg aacgaccatc tttggtattc tctataaaat ctttgctaaa aatgtcaatg
    15901 agaaatttag ccttgctctt tacctgatta tgggctggtt ggttctggct atcattcctg
    15961 ccattatcag tcaaacgaca cccgttttct ggagtctcat ggtaactggc ggactctgtt
    16021 atacagttgg agctggattt tatgccaaga aaaaacctta tttccacatg atttggcatc
    16081 tctttatcct agctgcgtcc gtacttcaat acatcgctat tgtttattac atgtaaaaaa
    16141 gttgagaaat tcaatctcaa cttttttctt tacacatatt gataaagtac tggtgcaagc
    16201 gcacatcatc agtcaattct ggatgaaaag aacttaccaa catatttttt tcttgggctg
    16261 caacaatttg attgttcact gttgctagaa tttctacacc ctcaccaaca ctactgataa
    16321 tcggaccacg gataaaggtc attggaatct tgccaactcc cttacattct gcttccgtgt
    16381 agaaacttcc taattggcgc ccataagcat tacgctcgac caccatatcc atagttccta
    16441 gataactctc tttctgagaa gtgatttcct tagccagcaa aattaagccc gcacaggtcc
    16501 caaacactgg taagccagat agaatggctt ctcggatgag aagtagcatg ttctggtcac
    16561 gtaagagctt gcccatggtt gtagactcac caccaggcaa aatcaaaccc gacaagtcac
    16621 tctgatcttg ctgaaaatca tctagatttc tgagttctac actctcgaca cctaattgat
    16681 ctagcacttt tgcatgttct gcaaaggccc cttgcaaggc caatattccg attttcatct
    16741 attttcctcg ttcagccatg agaatttgga tttcattttc attaatacca accatggctt
    16801 ctcctaaatc ttcagagatt tgagctagga tttgaggatt acggaagtta gtcacagcct
    16861 taacaatggc actcgctcgt ttaacaggat ctcctgactt gaaaatacct gaaccgacaa
    16921 agaccccctc tgcccctagt tgcatcatta acgcagcatc tgctggcgtt gcaacacctc
    16981 cagcagcgaa atttacaact ggcaattttc catgttcatg aacatattgg accaattcta
    17041 cagggacttg caaatccttg gcagcaacat aaagctcgtc ctcacgtaag ttttgaatgc
    17101 ggcgaatttc ctgattcatc atacgcatat gacgaacagc ttggacgata tcccctgtcc
    17161 ctggttctcc tttggtacga atcatggaag caccttcagc gatacgacgc aaggcttcac
    17221 ccaaatcctt agcaccacag acaaaaggaa cttggaattc tttcttgtcc acatggaaac
    17281 ggtcatcagc tggagataga acttcactct cgtcgatata atcaatttca atagcctcta
    17341 aaatctgagc ttcaacaaaa tgcccgattc tgaccttagc cattactgga atactaaccg
    17401 cttcttggat ttccttaatc atctttgggt cgctcatgcg ggaaactcct ccagctgcac
    17461 gaatatcagc cggaattcgt tccaaggcca tcacagctgc cgcaccagca gcttctgcga
    17521 tacgagcctg ttcaggattc tgcacatcca taataacacc acccttgagc atctgtgcca
    17581 agtttttatt tagttcataa cgattttcag tcatttgttt tatcctcatc atttgtattg
    17641 gtagctacct tttcatttta agtcagaaca gaatgaagca caagataaaa aaactataat
    17701 tgtatgggga caaattagct aaaaactatc tgaccttaac ttaaggccag atagctcatt
    17761 catttttatt tttcagccgt aagggcagcc attgtgatgt agttgtatgg tttgttgaag
    17821 tgtggcaaga agaagaggtc tgtcaatgcc aatttatcaa ttgtcacatg ctcttggata
    17881 gcaagtgaga acatgtggat tcccatgcta attgcaatat catgtgaaac catttgggca
    17941 ccaagaattt cacggctatc tttgtcaaag acaatcttaa ttgctacttc atggttgtca
    18001 tgtttcatga attctggttt ttgaagatcg ttaaagcctg tttcagttgc gttgtaacca
    18061 gcagctttcg ctttttcaag agtcaaacca gttgaaacca tgtgaagacc gtagattgag
    18121 ataccatttg aaccttgaac accgattcct tccaattcat gtccacaagc attgtaggca
    18181 ccaacgatac cagtgcgaac agcatttgaa gcaagagcga tatagcttgt atctttacga
    18241 gcattgtcat aaacagtcgc acagtcacca acagcgtaaa cgcctgggat agatgtttct
    18301 tgtttcttgt ctacaaggaa ggcaccgttg cggaagagtt cgatcttacc atctgcaagg
    18361 gctgtgtttg gacggaaacc aactgcaagg ataaccatat ccacgtcaaa gctttctttg
    18421 tcagtaatca agcgttcaac tttaccgtca ccttcgattg ctttaacagt ttgacctaga
    18481 gccaagcgga tgttgtgatc ttccaagttc ttcgccatca tttgtgtgaa gtctttgtca
    18541 tagtaaccgt tcaagacagt atcaacgata tcaacaagga caacttcttt tccaagacgt
    18601 tcaaaggctt cagcaagttc aacaccgatg taaccaccac caacaacggc gatacggtcg
    18661 aggtgttggc tcttgtcaga aagtttattg ataacttctt cagcattttg gtacaatttc
    18721 acgaattgta cgttttcaag agttgcttta aattcgcggt ttcctttaac aatttcaaca
    18781 ccttcgattg gtggcaagat tggtgtagaa cctgtagcga aaatcaattt ttcgtatgat
    18841 tctttgtgct cttttccttc aacttccgct gtaactactt tgttatcata gtcgattgaa
    18901 agaacaggtg agttcatgta aactttagca cctttagctt ccaatttttc tttatcagaa
    18961 tagaacaagc cttcagcacc gtcaatttgt tcaccaatcc aaagagccat tccacatcct
    19021 aggaaagaga tgttagagtt ttggtcaaat acaacaattt cgttctcatt tccaaaatta
    19081 tccaacatgg tattgataca tgctgtacca gcgtggttag caccgactac aacgatttta
    19141 ctcataaaaa tttcctgcct tcattctaaa tttaccttac tagtatacca tttaccgtta
    19201 gcgtttacaa ggggggtact attatttcag cattttttat caaaaataat tccccattta
    19261 tcctgttttc aagcctcatg aattttatga gcatatttct tgactttttc caaattttgt
    19321 ttgtgaaaat tctaacttta tggtattata ataacatgaa aatgaaatgt aagggcttca
    19381 atttagatga ttatttgata ttacaactta ttttctataa gagaaaggag ttggtagctt
    19441 gactcttcgt tcacattctg aacggctaat ggggactact atcactattt cattagtgga
    19501 tgagcaagcc gatatctttc tccaaaaatc ctttgacttg ctcaaagagc ttgaataccg
    19561 cttcaacgcc aatagtcaag aatctgagtt gatggaaatc aattatcaag caggaatatc
    19621 ccccgtcacg gttcatccag acctgtttga gctgatttca cttgggttag agcatagcct
    19681 agcgctctct agccacctca atatcagcat tggtccctta attcaaacct ggcgtatcgg
    19741 tttttcagat gccaaggtcg cccagcctca agaaattgaa tcggtgctgc ctctaatcaa
    19801 tcctcatggt atcgagttag attcttctac ttctactgtg tttttaaaac agaaaggaat
    19861 gaagatcgat ctaggttgtt tagccaaagg atacagtgcg gataaggttg cccaatttct
    19921 taggaaagag ggggtgactt ctgccttgat caatctggga gggaatatcc tgaccattgg
    19981 aaaaaatcag gcaagagggg ataacccatg gcaaatcggg attcaagacc cagccaatcc
    20041 gaggggaaat catttaatga ccatccctgt tgtcaataaa tctgtcgtga cttcaggcat
    20101 ttatgaacgt cacctgaccg tcgatggaca agattaccat cacatttttg acagtcaaac
    20161 aggatatcct gttgaaacgg aactagcgag tctaacaatc atctctgata aatcagtcga
    20221 tggcgaaatc tggacgactc gactctttgg agaaagacct gcttctatct tctggcaagt
    20281 cgaaagtttg gagggcatcg aagtcatcct catcgataaa gaaggccacc taagctgttc
    20341 ttcaggaatt cctactctat agagacaact gtttcaatgg aattttaaaa ttgtattatg
    20401 taaaaagaga aaggaaatct catgttaaaa cttattgcta ttgttggaac aaattcaaaa
    20461 cgttctacaa accgtcaatt gcttcaatac atgcaaaaac actttgctga caaagctgaa
    20521 attgagcttg ttgaaatcaa ggccattcct gtcttcaaca aaccagctga caagcaagta
    20581 cctgctgaaa tattggaaat tgctgctaaa atcgaagagg cagatggcgt tattatcggt
    20641 actcctgagt atgatcactc tattccagct gttttgatga gcgctcttgc ttggttgtct
    20701 tatggtattt acccactttt gaacaaacca atcatgatta caggtgcttc ttacggtacg
    20761 cttggttcat ctcgtgccca attgcaactt cgtcaaatct tgaatgctcc tgaaatcaag
    20821 gcaaatgttc ttccagatga attcttgctc tcacactctc ttcaagcatt taacccaagt
    20881 ggcgacttgg ttgaccttga tgttatcaag aaattggatg ccatctttga tgacttccgt
    20941 atctttgtaa aaatcacaga aaaattacgt aatgcacaag aattacttcg caaagatgct
    21001 gaagactttg actgggaaaa tttgtaagat aggagaccaa aaagaatgaa atttgttgga
    21061 cttgttggat caaactacga tcaatcatat aaccgtaagc tcttggaatt tatccgtcgc
    21121 tacttcaaac tcaaatttga attagaagtt cttgaaattg acgaagttcc aatgtttaac
    21181 caagatgaaa aatgggatga aagtttccaa ttacgttatt tatataacaa aattactcgt
    21241 gcagatggtg ttatcattgc tactcctgag cataaccaca ctatctcagc ttcactcaaa
    21301 tctgtacttg aatggctttc atacgaagtt catccatttg aaaacaagcc tgttatgatt
    21361 gtgggtgcat catactatga ccaaggaaca tcacgtgctc aagttcacct tcgtaaaatc
    21421 cttgatgctc caggtgttaa tgcctacacg cttccaggta acgaattcct tcttggtaaa
    21481 gctaaggaag cttttgataa caacggaaat atcaccaacg aaggcactgt taaattcctt
    21541 gaaacttgct tagataactt tgttaaatac gtaggagtcg tttcgaaatt gaaaaaacca
    21601 aaaccaatcg aatcagaaga cttggattgt ggaaaaccaa tcgctacaac catcacagaa
    21661 gttgaccctg acgatccaga atgggtagaa aaagttgcag caatcactgg tgctgtttct
    21721 ggtgatacct atgtcaaatt ggaccacggt atcctaacag ttaaccaaat tgatatgttc
    21781 ttgaaagcta tgccatttga attgacatac gctgacgaca acaaccaatt cctctactac
    21841 aacaacgctc accaagatcc agacactatg ttcgctaaac gtgtaccacc tcaatcaggt
    21901 agccgtatgt cgactgttca tggttctctt ccaccagcac gtatgaagaa cgtagagtgg
    21961 gttatcggaa cacttcgcaa cggaaaccaa gaatacgtcc gtacgatcgt tccaggttct
    22021 cctgcaggtg ttatcaacac tcacaactac caagcaatgt actatcctga tggatcatac
    22081 gctggtatca atgaaatcgt ctttaacttc caaccatggc ttgactggta cctaaaagag
    22141 actggtcaac gtttggtggg tggtagcgga ccatttgctc ctgctgccgg aggtcatgga
    22201 gacgccgatg ctacttctgg cgcttctgat tcaggggatg ctggaggcca cggtggtgac
    22261 gcagacgcta cagccggtgc aagttactaa tgatagtttt taggaaccat tatggttcct
    22321 ttttagcgaa aaaagactag caaacacaaa ctgctagtct ctttgttatc gtttcatcta
    22381 tctttgttaa aagaaagaat acatattatg aatttggatc atcaagacta cggccatgta
    22441 atcctttttc acgttgtact tggcgtagtt tttctggtgt aacatcgttt ccttcttcgt
    22501 ccacaatttt gattccttca atgtggtgac gaacagcgcg gcgataacct tcgatgtact
    22561 cctcacgtag tttggcttgt tccacttttt cttctggtgt taagccttct gtttttttct
    22621 ttttagcaag ctcattgata cgagcaattt ttttcggatc catttcttct cctctgtaat
    22681 aagataaagt ccgtttatca aattttattt agtgttaatt tggttaaaac aagcaaactt
    22741 agctgctttc ttggttagtt gtgacaagat tgccaaacga ttttgacgga cagcctgatc
    22801 ttcagccatt accatagtat tttcaaagaa agcatcaatg actgggctaa gcgcaaagag
    22861 ttgtttcaat tgctgacttg caggtcctga taaaacgagt gtttctactg cttctgccaa
    22921 agctttttct tggtcattct caaatagtgc tgaatcaact gtagcaaccc cttctgcctt
    22981 ctcagccagg ttaaaggcac gagaaagtga ttcaacagat ggtttaaaat cttcttcctt
    23041 gcttacttct acgagagcac ttgctgcttc caacatatct gccacaacaa agtttgaacc
    23101 tgcaagaact gcttccttga tatcttttgg agtagagccc atcatcttat caacacgagc
    23161 cttgataaag tccataacct ctgctttatt ttcataagtc aaactgtcaa atttcaatgc
    23221 ataaaggcta tcaatcagct catccatagc aatgtgccaa ccaaaggcat ccaagatacg
    23281 aaccacacct tgagttgcac gacgaagggc ataagggtca ttagaacctg atggaatcaa
    23341 tcctactgag aagaaactca aaatcgtatc caatttgtct gcaatggcta gaactgcacc
    23401 gaccttgctc tctggaagtt ctccttcagc tgatgtaggc atgtagtgtt cacgaatagc
    23461 agctgccacc gctggagttt caccagcaag aagggtgtat ttttcaccca taattccttg
    23521 gagttcgtca aattcaccaa ccatacctgt caacaagtca aacttgtaaa tggctgctgc
    23581 acgagcaagg tcaactgttt catccactga caaaccagct ttttctgcca aaagtacagt
    23641 gatttgaccc gtacgaatca tgtgttcacg aagggaacca atcttctcat ggaaggtgac
    23701 attgtttaat ttttcaacaa gatctgaaat caccaatttt tggtcttcac gccagaagaa
    23761 ttctccgtct tccaagcggg ctaccaagac tttttcattt cctttgatga catttttcaa
    23821 acgctctgcg tttccgttac gaacagaaat gaagtttggc aagagttttc catcttgatc
    23881 acgaacaaca aagtaacgct ggtgttcctt catagaagtc accaagactt cttctggaac
    23941 ttcaaggtat ttagcatcaa aacttcccat gaaggcagtt gggtattcaa ccaaattcaa
    24001 gacttcattc agcaaatccg catcaatttc gatacgtaca ccatgttttg cctcaatttt
    24061 cttgatttgg tcaacaatca tttgctcacg ttcacatgga tctgcgatta caaactgctt
    24121 acgaaggtct tcttcatagc tcaatgctga ctgaattttg gtttctttcc ccaagaaacg
    24181 atggccacgg ctcacacgac ctcccttgat atcaaggaaa tccaagtcaa actcttgctc
    24241 atccaagaga acagttaaag tgtgaacagg gcggatgtat tcaaagctat ttccagccca
    24301 gtgcatgctg acagggaaag tcaatgactt caagacatct acaacaccag gaacaatggc
    24361 ttcaactgct tgaccaactt cttccttagt gacatagaca tattcttcac ccttgatttc
    24421 acggaattcg atatcttcaa cagtcaagcc ttttccacgg acaaatcctt gagctgcttt
    24481 ggtgaagttt ccatcactat ccaaggcaat ttcctttgct ggtcccttga aatcttctgt
    24541 caaatcagac tgtttgtctg ataaaccagt cacacgaaca gccaaacgac gtggtgttga
    24601 gaaggtttga atggcttcaa aagacaggcg gttttccttg aggaaggctg ccattttttc
    24661 gcctagttgt ttttcacttg gtgtgacaac ataggctggt aattcttcaa gaccgagttc
    24721 tactaataag ttttttgtca tgttttttct ccgaaaagta tctttttatt ttccagtttg
    24781 ccttatgtga ttggcacgca agcaaccaac ttcgttgttt cattgctaaa attggagcca
    24841 aaagtctcca attttgccta gtatccttag tttcactaag gataccttca tcactgcggc
    24901 aactgactca gggctcactc tgttcgccca ttttcgtaat ttgtcactct ctttattctg
    24961 cgtcttctgc taggagttta gctcttgttt cttcatccaa aagtgggtaa cctaggcgtt
    25021 tgcgttctgc aacaaaggtt ttggctacaa cacgggccaa gttacggata cgagcgatat
    25081 agcctgcacg ctctgttaca gatacagcac cacgcgcgtc aagcagatta aaggtatgtg
    25141 aacatttgag aacatagtca taggcagggt gtaccaagcc ttcttctaat gcacgaccag
    25201 cttctttttc aaacttatca aagttttcaa gcaacatttc ttggtccgaa atttcaaatg
    25261 aatattttga gtgctcatac tcaggctgga taaagatttc tccgtatttt acaccatcag
    25321 cccactcgat atcatagaca gagtctactt cttgaatgta agaagccaag cgctccaaac
    25381 cataggtaac ttccgcagtc acagggccag ttgccaatcc accgacttgt tggaaataag
    25441 tgaactgagt gatttccatt ccgtcaagcc aaacttccca accaagacca gctgaaccag
    25501 ttgatgggtt ttcccagttg tcctcaacaa aacgaatatc gtgctccaaa ggattgattc
    25561 ccaatttttc caaagactca aggtaaagtt cttggatatt tgatggagaa ggcttcatga
    25621 ccacctggaa ttggtggtgt tggtagagac ggttagggtt ttccccataa cgaccgtcag
    25681 caggacgacg tgatggctct acataagctg cattccatgg ctcaggtccg atagcacgaa
    25741 ggaaagtgta aggactcatt gttcccgcac ctttttcatt atcataagcc tgcataagca
    25801 tacaaccttg gtcattccaa aattgttgca aagtaaggat gatttcctgg aaagtcaatt
    25861 tcttagacat tgtttactcc tttttatata aattacttgc gacatgagtc tgcctcgtcg
    25921 atcatacgag gcaagacgag ttagtactgc gtctagctca ggcactctag tgctgagcgt
    25981 ggggcagtcc gactgtaagg aggtttctgc cactgatgca gtaaaatgtt aatttcttag
    26041 acattgaata ctccttaata aaaaatgatt tcttgcgaca cgagtctgcc tcgtcgatta
    26101 tacgaggcaa gacgagttag tactgcgtct agctcagcac cctagtgctg agcgtggggc
    26161 agtccgactg taaggaggtc tctgccactg atgcagtgaa atgttaattt cttagacatt
    26221 gtttactcct ttagttttta tatttctttt tcaattaatt tctgctgaac aaaccaatct
    26281 aacaagggaa aagttttttc tgtatttgcc cataaatgat aagaatctaa gaccgcttgt
    26341 acactaccta aattttctac caacttatct actgtcaaaa agcttcgcca gtattcataa
    26401 aaaatacttg catagttctt atcataagtc gaagaaccaa aatcattcaa tgaatgccaa
    26461 ccatacttct tctgaaaaag ttctacgaga gattgattac aaattttttc cgcttgaaat
    26521 tcctcttctg taaagaaata cttgcgacta atatattcaa ccatcccctc ttcgaaccag
    26581 atataagagt cataaccatc aaaatcatct aaaaaatgct ccgaccaatg agctaactca
    26641 tgtcctacaa tctgtaagag gaaattttca gataaagaat gatagtgact ttctattgct
    26701 tgagtttgct cagaacactc gtagtccatc aattgataca aatacaactc tttccaaaca
    26761 gctaaatcag gcgccataac cattcgtcta ttatttgtat aggctggaac agcgctttcc
    26821 ctaataatct gtgtagcagc attaaaatct gaccaaataa cggcttgcgg taaatcacag
    26881 actgcaagtt cattctttaa aaaagattga taatctttca acttttcagt atttcttact
    26941 acaaaatcac gaaatgtagc tagttgacta tcgtctttta caagataaag gttgtccacg
    27001 gctctccttt ctttcacaca atagactgaa taagcaaaag aaccgcgtcc gacaatccta
    27061 ggttgattta acctaggggc gtcagaaacg cggttccacc ctaatttatt acttcattgt
    27121 ttttgaaaat actacagaaa gcgccagctc attattttgc cctacttggc tcccactatc
    27181 ccaagctcgc ttgaagaacg ccataagact ttctttcctg ctgactatta tatcaaaaat
    27241 tagaataatg tacaattctt tttatgattt tctagaaatc cacatcatca actcgtggag
    27301 cacccgattg aacagcaatc gtttttaagg tttctctctc ctcatgactc agttcaattc
    27361 caaagcaatc aagattagct tgaatacgag aggttgtgac agattttgga agtggtaaaa
    27421 atccttctgc caagctccag gccaaggcta tctgagcaat cgattttccg tgatttgctg
    27481 cgatttcttg cacttgcttg ctatcaaata gttctccctg accaaaaggc ccccaagctt
    27541 ccaataaaat tcccttttca cgacagtaag ctacgacttg atcttgatac acacctggcg
    27601 ccaagcgaac ttgattgacc gcaggaacga tagttgcagt ttcaagcaag gcatccaaat
    27661 gatggggaag aaaattgcta acgccgatag cacggatttt cccttcttga tagaggtctt
    27721 ccatcgctct ccaaacttcc gcattgcgag ttttccatgc gtcattttct ctgagcggtt
    27781 ttgggttcgg ccaatgaatc aaatacaaat ccaaataatc caagcccagt ttttctatag
    27841 atttttccaa agcttgacga gtttgctcat aggtttgctg actattccaa agcttggtag
    27901 ttacgaacat ttcttcacgt ggaactccgc tatctttgat tgcttgacca acactttctt
    27961 cattctgata aatcgccgcc gtatcaatat gacgataacc agccttcaag gcttctaaca
    28021 ctgcatgata ggcttcttct ccatccttag ccttaaaagt tccaaatccc aatactggaa
    28081 tttctactcc attatttaat tgataggtat tcatatgctt ctccttctat tttattcatc
    28141 aattatagca taagacattt tttaagtagt actatcttct gtaaaaaata agtctgtcaa
    28201 atatctaaca gacctatttt ttcttgctta ttcatcacga ctatagtaca gctcatgagc
    28261 ttttaggcga gtattgagca tctctggtat ggtcacaaag gtataacctt gatttttcaa
    28321 atactcaatg acccttggca aggcattgac tgtcggactg tgaatatcat gcatcaaaac
    28381 gatagagccg ttagctactt gatgctgaat ttctgtcaaa atagatgctt catttttact
    28441 cttccagtcc agactatcca catcccacat gataaagctc aaatccaagc tattgcgaat
    28501 atcatctgta atagcaccat aaggtggacg catgagttta gaactagaac ccagcacttt
    28561 agttagcaca tcctcagtat cagtaatctg ctttttagct tcatcaagag agagttgcga
    28621 gagaatcgga tggctccaac tatggtttcc aacaacatga ccttcagatt ttatcctctt
    28681 caccaagtcc tcattcccag aaacattttt cccaagcaca aagaaagtcg ctttaatatc
    28741 atatttagct agggtctcta atacctgcgg ggtcgttgct ggatttggac catcatcaaa
    28801 ggttagagcg acaacttttt gatatttctt atcaaagtaa gattgataca aggccgcatc
    28861 tttttcgagt aagtacgaag attggataac atcaaagaaa gcagatactg gcaaggctat
    28921 ctcttctaaa ttttcaagca caggacttga ataaaggata atctgactat ccttgtaatc
    28981 aaaattccat gcagacaagt cttggtcaga gaagcttttt acaatctgct cactctggtc
    29041 ttgctctatt tttttatcct ctatgaagga ggtcaactct tttatcagct gttccttagc
    29101 cttactagca tctgaaaaca gttggtcaag tgtaaaaggt tgcccatctt ctgttaagtg
    29161 aacctttcct agactggtct tttcagtctc ttcaacctta aaagcaacta aatcatagat
    29221 ttgtttggtc acattacgat taacgactcc ctttaaacct gactcttctt gctctgtata
    29281 gtagaaaaca agattgtcct tactttctag cttgtcctta acatcttgat ttatcaactc
    29341 cctaacagag gaaatcactt tctccccttg gagaggataa taggcaatca cttcggcttg
    29401 cccctgacga aaatgctcct tctgatttcc ctcactcaat tgatcatctt tctctttttt
    29461 gagcgattca atcttttgct caaaactttt ttgctggtag atcttaaaag caataaatcc
    29521 gcctaatagg caaatagaaa ttgctaagat accaatcaaa gccaataata catgtctcgt
    29581 tttcccgtgt ctgccacgtc ctagtctact tttattcata tttatatcat aacaaatttg
    29641 agcaataatt tcaatgatac aatttggcaa tccacaattc ctctagcaag ccaaagcatc
    29701 ttacatcaac tccaacatcc gtatctgtag agattatgta gttttctatc tatggaattt
    29761 ctagtaaatt gaagctagaa tagtagacct atacttctaa aacattgtta gaaatcgatt
    29821 tgattgtcct gatcgatttg tcctgttctt atttcatttt actataaaac tatgaaaagc
    29881 taggtcatct gagaagtaat tactatcgac aattgcgata gcgtatactg gtgcgatttg
    29941 tttgtagctc tggtgggtat caccttcacg ttggcgaatt ttttctaggt tttgattaac
    30001 ctgactgcac agataagccc ataggcgatt gatgaaaaaa ttctgatgat gaacctgaat
    30061 ttcgatgata acttgaattc cattatctaa ctccgccaag acgtctatac tagtatagaa
    30121 atcctgcgct gagtaggaca tggaaggcaa gacgtgaatg ttacttccct ccaaaatcgt
    30181 cacatttttt gctggcaagt ccagcatatc gcggataaat tgacaaatca ttagttgggc
    30241 tgatacccgg atgtctgaga atcctccttt tcctccttct attatagcac atttttaaat
    30301 ctaggtttgc tagattctat gcttctatct atttattcgg aaaagaaagc ttttcttcag
    30361 aagaaagcta atagcttatt tgaaattttc tcctctctgt tggatagtcc cgtctatcta
    30421 tgttataatg aaagaaggat ttaaaatcgg aaaaggagta tttatgctaa aattaggtgt
    30481 catcggaact ggcgctatca gccatcattt catagaagca gcccatacca gtggagaata
    30541 ccaactggtc gcaatctatt ctagaaaact agaaactgca gcaacctttg cttctcgcta
    30601 tcagaatatc caactattcg atcaattaga agtcttcttc aaatcttctt ttgatttagt
    30661 ctatatcgcc agtccaaact ccttacattt tgctcaggca aaagctgcct tgtctgctgg
    30721 taaacatgtt attctcgaaa agccagctgt cactcaacca caagaatggt ttgatttgat
    30781 tcaaacagct gaaaaaaata actgttttat ctttgaagca gctcgtaatt accacgagaa
    30841 agcctttact actatcaaaa actttttagc agataagcaa gtgttaggag cagatttcaa
    30901 ctattccaaa tactcttcca agatgcctga cttgttggct ggacaaacac caaatgtctt
    30961 ttcagaccgt tttgctggtg gagccctcat ggatttgggg atttatcccc tctatgctgc
    31021 tgttcgtctt tttggaaaag ccaatgacgc gacttaccat gctcaacagc ttgacaatag
    31081 cattgaccta aatggagatg gtaccctctt ctacccagac tatcaagttc acatcaaggc
    31141 tggaaaaaac atcacttcca atcttccttg cgagatttat acaacagatg gaaccttgac
    31201 tctcaacacg attgagcata ttcgctcagc tatttttacc gaccaccaag gaaatcaagt
    31261 ccagcttcct atccaacagg atcctcatac gatgactgag gaagtcgctg catttgcaca
    31321 catgatccag caaccagatc tgaatctcta ccaaacttgg ctgtatgatg caggctctgt
    31381 tcatgagcta ctatatacca tgcgccagac tgctggcatt agatttgagg cagaaaaatg
    31441 aaaaccaaac taccgactga atggcaagaa ctgagtgacc aactcggttt ccaagaattc
    31501 accctcattc aaactcaact atttgagccc cttcttgctg gagaaaacct cctaggagtg
    31561 agccaaaccg gaactggtaa gaccctagcg tatctcctac caagtcttct cagactacaa
    31621 aagaaaaaag cccaacaact cttgattcta gcaccaaata cggaacttgc tggacagatt
    31681 tttgatgtat gtaaaacgtg ggcagaagct atcggattga ctgctcaact cttcctttca
    31741 ggttcaagtc agaaacgaca aattgaacgc cttaaaaagg gatcagaaat tctgattgga
    31801 actcctggcc gtatctttga actcattaaa cttaaaaaaa tcaagatgat gaatgtggaa
    31861 accatcatcc tggatgaatt tgaccaatta ctagatgatt ctcagattca ctttgtagaa
    31921 aaaatcactc actacgcacc tcgtgaccac caactggtct acatgagtgc cacgaccaag
    31981 tttgaccaag aaaagattgt gccgaataca cgcactattg atctctctga tcaaaaattg
    32041 gacaatatcc agcatttcta catgcaggta gaccaacgtc atcgagtgga tatgctacga
    32101 aaactggctc atgtagagga tttccgtggt ctagtcttct tcaatagcct gtcagacctt
    32161 gggaatgccg aggaaaaact acagtatcgt gatatattgg ctgtttccct cgctagtgat
    32221 gttaatgtta aatttagaaa aatcatctta gaaaagttta aagataacca actaaccctg
    32281 cttcttgcaa ctgacctttt ggctcgtgga attgatatcg atagcctaga atgtgtcgta
    32341 aactttgata ttcctagaga tagcgaaacc tacacacacc gtgctggccg tactggtcgt
    32401 atgggcaagg aaggttatgt tatcactctc gtcactcatc cagaagaaat caaaaaactt
    32461 aaaaagtttg caagtatccg agaaattgtc ctaaaaaacc aagaactcta tatcaaataa
    32521 agccctattg ctctatacac atccagtgta tggagctttt ttataagcaa ttcaatttta
    32581 tactcatctg ctttcaaaaa gcattctagt ccatttccga ttaacgatgg actttatcac
    32641 ctccttctcc agtccttg
//
LOCUS       DBMVGT010000015        31089 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.015, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000015 DBMVGT010000000
VERSION     DBMVGT010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 31089)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31089)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31089
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.015"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(308..604)
                     /locus_tag="AC0DU4_000784"
                     /pseudo
     CDS             complement(308..604)
                     /locus_tag="AC0DU4_000784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_027973981.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            901..1173
                     /locus_tag="AC0DU4_000785"
                     /pseudo
     CDS             901..1173
                     /locus_tag="AC0DU4_000785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000547411.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(1284..1487)
                     /locus_tag="AC0DU4_000786"
     CDS             complement(1284..1487)
                     /locus_tag="AC0DU4_000786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HIN4236779.1"
                     /translation="MSVEEKLNQAKGSIKEGVGKAIGDEKMEKEGAAEKVVSKVKEVA
                     EDAKDAVEGAVEGVKNMLSGDDK"
     gene            complement(1518..2126)
                     /locus_tag="AC0DU4_000787"
     CDS             complement(1518..2126)
                     /locus_tag="AC0DU4_000787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HIN4236780.1"
                     /translation="MSNEKNTNTNVEKKDATVVAHEIKGELTYEDKVIQKIIGLSLEN
                     VSGLLGIDGGFFSNLKEKIVNSDDVTSGVNVEVGKTQVAVDLNVIVEYQKNVPALYSE
                     IREIVSSEVAKMTDLEIVEINVNVVDIKTKEQHEADSVSLQDRVSDVAESTGEFTSEQ
                     FEKAKSGLGSGFSTVQEKVSEGVEAVKGAANGVVSHENTRVN"
     gene            complement(2165..2335)
                     /locus_tag="AC0DU4_000788"
     CDS             complement(2165..2335)
                     /locus_tag="AC0DU4_000788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2273 domain-containing protein"
                     /protein_id="HIN4236781.1"
                     /translation="MEWLKQYRYPIIAGLIGVFLACLIVSFGFFKTIFVLILGALGVA
                     AGLYIEKNYIDK"
     gene            complement(2347..2913)
                     /gene="amaP"
                     /locus_tag="AC0DU4_000789"
     CDS             complement(2347..2913)
                     /gene="amaP"
                     /locus_tag="AC0DU4_000789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000030212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline shock response membrane anchor protein
                     AmaP"
                     /protein_id="HIN4236782.1"
                     /translation="MSKAKKICFIIFCILILTIFLPVLIDYHQVSNLGIHLLSWRQNS
                     VVEFYLARYVFWGTVVLSTLVLLSILVVMFYPKRYLEIQLETKNDTLKLKNSAIEGFV
                     RSLVSDHRLIKNPTVHVNLRKNKCFVHVEGKILPSDNIADRCQIIQNEITNGLKQFFG
                     IERQVKLEVAVKNYQPKPQNKKTVSRVK"
     gene            complement(2997..3161)
                     /locus_tag="AC0DU4_000790"
     CDS             complement(2997..3161)
                     /locus_tag="AC0DU4_000790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HIN4236783.1"
                     /translation="MGIIANVFAGLVGAYAGQSLLGSWGPSIAGMALLPSIVGAAIVI
                     TVVSFFTGRK"
     gene            3604..5085
                     /gene="mgaSpn"
                     /locus_tag="AC0DU4_000791"
                     /gene_synonym="mgrA"
     CDS             3604..5085
                     /gene="mgaSpn"
                     /locus_tag="AC0DU4_000791"
                     /gene_synonym="mgrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="virulence factor transcriptional regulator
                     MgaSpn"
                     /protein_id="HIN4236784.1"
                     /translation="MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKD
                     DLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQ
                     AESICKEFYISSSSLYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYFSE
                     KYYFLEWPFENFSSEPLSQLLELVYKETSFPMNLSTHRMLKLLLVTNLYRIKFGHFME
                     VDKDSFNDQSLDFLMQAEGIEGVAQSFESEYNISLDEEVVCQLFVSYFQKMFFIDESL
                     FMKCVKKDSYVEKSYHLLSDFIDQISVKYQIEMENKDNLIWHLHNTAHLYRQELFTEF
                     ILFDQKGNTIRNFQNIFPKFVSDIKKELSHYLETLEVCSSSMMVNHLSYTFITHTKHL
                     VINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKESLEDSP
                     YDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAMMFIRLDE"
     gene            5447..6448
                     /locus_tag="AC0DU4_000792"
     CDS             5447..6448
                     /locus_tag="AC0DU4_000792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HIN4236785.1"
                     /translation="MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQ
                     AIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFFSEFAMHVENEVYKRNNKLLLCS
                     INGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSD
                     NDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDE
                     TVTDYYGKLESFLEENSSIDGIFTINDFTALDVIEILEKNGKRIPHDVQIIGYDGIKM
                     AGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVKFVEGKTTKNENKS"
     gene            6599..7516
                     /locus_tag="AC0DU4_000793"
     CDS             6599..7516
                     /locus_tag="AC0DU4_000793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001084977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236786.1"
                     /translation="MNSKAKQVSLWERIKKQKLLLLMTVPGLVLTFIFKYIPMYGVLI
                     AFKDYNPLKGILGSDWIGFSEFTKFISSPNFGILLANTLKLSIYGLLLGFLPPIILAI
                     MLNQLLSEKVKKRIQLILYAPNFISVVVIVGMIFLFFSVGGPINNFLSMFGMKADFLT
                     NPDFFRPLYIFSGIWQGMGWASTLYTATLVNVDPALVEAARLDGANIFQRIWHIDIPA
                     LKPIMVIQFVLAAGGIMNVGYEKAFLMQTSLNLPTSEIISTYVYKVGLVSGDYSYSTA
                     VGLFNAVINVVLLVAVNQIVKRMNNGEGI"
     gene            7527..8417
                     /locus_tag="AC0DU4_000794"
     CDS             7527..8417
                     /locus_tag="AC0DU4_000794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000797960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4236787.1"
                     /translation="MKNSIMDTKFDRRILLLNKIIIVFIVLMTLLPLLYIVVASFMDP
                     KVLVSRGISFNPADWTVEGYQRVFSDQSILRGFINSLLYSFGFAALTVLLSVFTAYPL
                     SKKDLVGRRWINYFLIVTMFFGGGLVPTYLLVKELGMLNTPWAIIVPGAVNVWNIILA
                     RAYFQGLPEELVEAAVIDGANDLQIFFKIMLPLAKPIMFVLFLYAFVGQWNSYFDAMI
                     YIKDPNLEPLQLVLRKILIQSQPGQDMIGAQAAMNEMKRLAELIKYATIVISSLPLIV
                     MYPFFQKYFDKGIMAGSLKG"
     gene            8446..10062
                     /locus_tag="AC0DU4_000795"
     CDS             8446..10062
                     /locus_tag="AC0DU4_000795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4236788.1"
                     /translation="MKFKTFSKSAVLLTASLAVLAACGSKNTASSPDYKLEGVTFPLQ
                     EKKTLKFMTASSPLSPKDPNEKLILQRLEKETGVHIDWTNYQSDFAEKRNLDISSGDL
                     PDAIHNDGASDVDLMNWAKKGVIIPVENLIDKYMPNLKKILDEKPEYKALMTAPDGHI
                     YSFPWIEELGDGKESIHSVNDMAWINKDWLKKLGLEMPKTTDDLIKVLEAFKNGDPNG
                     NGEADEIPFSFISGNGNEDFKFLFAAFGIGDNDDHLVVGNDGKVDFTADNDNYKEGVK
                     FIRQLQEKGLIDKEAFEHDWNSYIAKGHDQKFGVYFTWDKNNVTGSNESYDVLPVLAG
                     PSGQKHVARTNGMGFARDKMVITSVNKNLELTAKWIDAQYAPLQSVQNNWGTYGDDKQ
                     QNIFELDQASNSLKHLPLNGTAPAELRQKTEVGGPLAILDSYYGKVTTMPDDAKWRLD
                     LIKEYYVPYMSNDNNYPRVFMTQEDLDKIAHIEADMNDYIYRKRAEWIVNGNIDTEWD
                     DYKKELEKYGLSDYLAIKQKYYDQYQANKN"
     gene            10072..11391
                     /locus_tag="AC0DU4_000796"
     CDS             10072..11391
                     /locus_tag="AC0DU4_000796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HIN4236789.1"
                     /translation="MGDKKYTVEKANRFIAENKHLVNTQYKPEEHFSAEIGWINDPNG
                     FVYFRGEYHLFYQFYPYDSVWGPMHWGHAKSKDLVTWEHLPVALAPDQDYDRNGCFSG
                     SAIVKDDRLWLMYTGHIEEETGVRQVQNMAFSDDGIHFEKIEQNPVATGSDLPDELIA
                     ADFRDPKLFEKDGRYYSVVAAKHKNNVGCIVLLGSDNLVEWQFESIFLKGVEHQGFMW
                     ECPDYFELDGKDCLIMSPMRYQREGDSYHNINSSLLFTGKVDWGEKCFIPESVQEIDH
                     GQDFYAPQTLLDDQNRRILIAWMQTWGRTLPTHDQEHKWACAMTLPRILRLEDGKLRQ
                     FPVKKGQYQIQIDKDCHYHLGNDIDYLEFGYDSNAQQVYIDRSHLIQKILGEEEQDTS
                     RRYVDIEAKELEVVLDKNSIEIFVNQGEASLTATYYLTVPAELSRID"
     gene            complement(11601..11673)
                     /locus_tag="AC0DU4_000797"
     tRNA            complement(11601..11673)
                     /locus_tag="AC0DU4_000797"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(11638..11640),aa:Lys,seq:ctt)
     gene            complement(11938..13209)
                     /locus_tag="AC0DU4_000798"
     CDS             complement(11938..13209)
                     /locus_tag="AC0DU4_000798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001113185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HIN4236790.1"
                     /translation="MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMIL
                     YGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHR
                     LDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQ
                     IALSNPERGFDFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDEGIRHITL
                     DIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYTARLIEAGDLPSLAR
                     RLTVIAYEDIGLANPEAQIHTVTALDAAQKIGFPEARILIANVVIDLALSPKSNSAYV
                     AMDKALADLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWVKQDYLPEKI
                     RNHHYFQAEDTGKYERALAQRKEAIDRLRKI"
     gene            13479..13679
                     /locus_tag="AC0DU4_000799"
     CDS             13479..13679
                     /locus_tag="AC0DU4_000799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000818079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236791.1"
                     /translation="MKREVISNGNDGPSQEILIFTKQIRHWILSDQVISGKRKLFFRE
                     DTPKEILDLYENIKSKLDFAYQ"
     gene            13883..14062
                     /locus_tag="AC0DU4_000800"
     CDS             13883..14062
                     /locus_tag="AC0DU4_000800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236792.1"
                     /translation="MNLIFEEYQFVKIGDKKYRVRSVPMIHSTPPQSVLDRDTFTIDY
                     TDDELLDKEAVFTTH"
     gene            14199..14378
                     /locus_tag="AC0DU4_000801"
     CDS             14199..14378
                     /locus_tag="AC0DU4_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003729 - mRNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicA family
                     toxin"
                     /protein_id="HIN4236793.1"
                     /translation="MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGE
                     LNKYTERGIRKQAGL"
     gene            14415..14867
                     /locus_tag="AC0DU4_000802"
     CDS             14415..14867
                     /locus_tag="AC0DU4_000802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000961815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="HIN4236794.1"
                     /translation="MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAM
                     GSEWLGITVADLIESDGELPQPSDINSLSLIDNDPFKDDEDFVSTYDLDKSFISMVSV
                     DVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA"
     gene            15158..15628
                     /locus_tag="AC0DU4_000803"
     CDS             15158..15628
                     /locus_tag="AC0DU4_000803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3013 family protein"
                     /protein_id="HIN4236795.1"
                     /translation="MATYGFLDVLEEELDKNFPFDFEISWDKRNHAVEVSFLLEAQNA
                     AGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNEEDYLTVIPYLPKKGFSREFLAYF
                     ALFLKDTAEVGLDVLMDFLEDPEAEEFIMEWNQEVFEEGKVGLEEGEFYPYPRY"
     gene            15684..16226
                     /locus_tag="AC0DU4_000804"
     CDS             15684..16226
                     /locus_tag="AC0DU4_000804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000891119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236796.1"
                     /translation="MLEKVKQFFRSRSAKTEPSVDILPRNRFEDLDFERVLKSGARRL
                     VNEEGRYAEDGKITELEFPEDFAEFEFLVGFKTEEEEQFQQLLARLNSIDNAIQSYLE
                     SEMQQPIPQYAKDLGYTQKRWEKTFYFHHWILSGEENPPNLRYVADYVNDEFTVYFAK
                     KHGRWQAYWDAECQKVIEES"
     gene            16276..16440
                     /locus_tag="AC0DU4_000805"
     CDS             16276..16440
                     /locus_tag="AC0DU4_000805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000421870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="7,8-dihydro-8-oxoguanine-triphosphatase"
                     /protein_id="HIN4236797.1"
                     /translation="MELLNSRMDFQGCKIALFCGDKLLTILRDDKDDIPCPNMWELPG
                     GGKSVRENLI"
     gene            16550..17584
                     /locus_tag="AC0DU4_000806"
     CDS             16550..17584
                     /locus_tag="AC0DU4_000806"
                     /EC_number="3.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HIN4236798.1"
                     /translation="MKKSDVLDLIKYHYEGRETEFRNQSIAIARNFNKHGDTQIAQYI
                     MGLMSQSDRFMPQIENPSEYLTPAKLDIGPLPLPLSIMNDLKGIINAVNHHIGINKFL
                     FVGSPGTGKTESVKQVARLIGKELLVVDFSHLVDSKLGQTVKNLATLFNEINNLPFKQ
                     NYIILFDEIDSIVLDRVNQNDLREMGRVTSAFLKELDRLSPEIVLIATTNLFENLDKA
                     VTRRFDAIIDFDRYTDEDKVEVATIILNELLKQFKNVARDLKLFKKIINSANVIPNPG
                     DLRNSIRTSLAFSDPSDPHDYQKRLLRSLHNGRNLSISKLSKLGFTVREIEILTGISK
                     SSVSRELSED"
     gene            17586..19829
                     /locus_tag="AC0DU4_000807"
     CDS             17586..19829
                     /locus_tag="AC0DU4_000807"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008288790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HIN4236799.1"
                     /translation="MNTLLTLRGKSFTPKSAKGRGPITIPADSIVTLNHLNELYTSLE
                     RVKEYWSNNTIIDGVLISVYYNRVLAKSNRIDGFFNVGGGNAIPNETIVGAKFSNDKS
                     RHIITHYISKEVLDKTIEHTKKVITIFKDYFASAPMTSMVFSDSSKFNQIDYSKYGLS
                     KSKFKQYLRDACFVKGFGIEQADMSTIRNSIVTIYDVKTNLLTLLKQLDIDVSEANIM
                     DQTTVLLDEKNIELLLLKAPYLVSMIVEDFSSLSPENFYNDGNTFYNNLPFPTNEPII
                     GVIDTLFDDRVYFNEWVEYHDLISPDISKGSQDYKHGTAVSSVIVDGASLNPKLDDGC
                     GRFRVRHFGISLQSGFNSFTIIKQIREIVSQNPDIKVWNLSLGSNDEIRENFISVEGS
                     LLDEIQFDNDVIFIIAGTNGIAPDGQRKKIGAPADSLNSIIVNSVDFSNQVVSYSREG
                     VVLSFFIKPDVSYYGGGNGDFINVCEPLGLARVAGTSFAAPFIARKMAYLIHIMGLSR
                     EEAKALLIDSAIPWNDKKTFADISLLGYGVVPIKIEDILSTPDDEIKFIVSDVSRAYE
                     TYNYDFPVPISKEHYPYVAKATMCYFPKCSRNQGVDYTNTEMQLSLGVLDKKGIKTIN
                     NDNQYSENAPGYVREKSARNIFRKWDNVKHLGEKFSSRKKAKPILNPSNPQWGMSVKT
                     IERLRNDDGYGIRFGVVVTLKELNGVNRIEDFIQQAELRGWLVNRLQVEAQVDLFNSL
                     NEEIEFE"
     gene            19880..20899
                     /locus_tag="AC0DU4_000808"
     CDS             19880..20899
                     /locus_tag="AC0DU4_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001028052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbiH family protein"
                     /protein_id="HIN4236800.1"
                     /translation="MNITYIVGNGLDLQYGLKTRYKDFYEFQNRTYISRKENEEEYSN
                     LIYESLFSDTVNDYENWSDFELSIGKLTKDNDLISSSIEIKEKFIDDFSEIVDDLREY
                     LRIQQEKNLEKGNAIDFISTLDNMRTSLPVINQPAIDKKYNENLYQHDIVNILTLNYT
                     NVIDKLYNESAKSFSNQLRTNNYKFHIAPPIHAHGTVDICTVLGVSDETQISNSFDEE
                     QKESLIKNLVLKNYRENMDVKNSDIIKNSDIIILYGVSLGETDGYIWNQIAEQSIRSS
                     VPVIIYHYVPHFDAGNPTRVKRLYRNVEDKFIQNSGIDLELEKKLRDNLIVVIGKTIF
                     NLMER"
     gene            20912..21862
                     /gene="prmA"
                     /locus_tag="AC0DU4_000809"
     CDS             20912..21862
                     /gene="prmA"
                     /locus_tag="AC0DU4_000809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000451122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HIN4236801.1"
                     /translation="METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSMDYVGNVD
                     RFGEIFPEVEQQEEIVVTAYYPDTVDVTVVEADLQARLAELTDFMDLGELKIGTTALA
                     EEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMS
                     IFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNPG
                     MENIHVVAGDLLKGVEIEADVIVANILADILIHLTEDAYRLVKDEGYLIMSGIIKDKW
                     DMVRELAESAGFFLETHMVQGEWNACVFKKTKDISGVIGG"
     gene            21864..22607
                     /locus_tag="AC0DU4_000810"
     CDS             21864..22607
                     /locus_tag="AC0DU4_000810"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001188214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HIN4236802.1"
                     /translation="MQQYFVKGSAISPVTIENKETSKHMFQVMRLKEEDEVTLVFDDG
                     IKRLARVLDMENRQFELVQELNDNVELPVQVTIASGFPKGDKLEFIAQKVTELGASQI
                     WAFPADWSVAKWDGKKLGKKVEKLEKIALGAAEQSKRNIVPSIKLFEKKADFLAQLDQ
                     FDSIIVAYEESAKEGEAAALLQAVTGLETGAKLLFIFGPEGGLSPAEIESFEAKGAVL
                     AGLGPRILRAETAPLYALSALSVLVELEK"
     gene            22618..24414
                     /gene="pepF"
                     /locus_tag="AC0DU4_000811"
     CDS             22618..24414
                     /gene="pepF"
                     /locus_tag="AC0DU4_000811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HIN4236803.1"
                     /translation="MEQKHRSEFPEKELWDLTALYQDREDFLRAIEKAREDINQFSRD
                     YKGNLHTFEDFEKAFAELEQIYIQMSHIGNYAFMPQTTDYSNDEFANIAQAGMEFETA
                     ASVALTFFDDALVAADEEVLDRLGKLPHLTAAIRQAKIKKAHYLGADVEKALTNLGEV
                     FYSPQDIYTKMRAGDFEMADFEAHGKTYKNSFVTYENFYQNHEDAEVREKSFRSFSEG
                     LRKHQNTAAAAYLAQVKSEKLLADMKGYDSVFDYLLAEQEVDRVMFDRQIDLIMKDFA
                     PVAQRYLKHVAKVNGLEKMTFADWKLDLDSALNPEVTIDDAYDLVMKSVEPLGQEYCQ
                     EVARYQEERWVDFAANSGKDSGGYAADPYRVHPYVLMSWTGRLSDVYTLIHEIGHSGQ
                     FIFSDNHQSYFNAHMSTYYVEAPSTFNELLLSDYLENQSNDPRQKRFALAHRLTDTYF
                     HNFITHLLEAAFQRKVYTLIEEGETFGASKLNSIMKEVLTDFWGDAIEIDDDAALTWM
                     RQAHYYMGLYSYTYSAGLVISTAGYLHLKNSETGAEDWLNLLKSGGSKTPLESAMIIG
                     ADISTDKPLRDTIQFLSDTVDQIIAYSAELGE"
     gene            complement(24474..24746)
                     /locus_tag="AC0DU4_000812"
                     /pseudo
     CDS             complement(24474..24746)
                     /locus_tag="AC0DU4_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000433071.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ArsR/SmtB family transcription factor"
     gene            24734..24916
                     /locus_tag="AC0DU4_000813"
                     /pseudo
     CDS             24734..24916
                     /locus_tag="AC0DU4_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714831.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015267 - channel activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin"
     gene            complement(24941..25114)
                     /locus_tag="AC0DU4_000814"
     CDS             complement(24941..25114)
                     /locus_tag="AC0DU4_000814"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236804.1"
                     /translation="MKIKEQTRKLAAGYSKHCFEVVDRTDEVSNHTYGKVKLTWFEEI
                     FEEYHTKKPCSSR"
     gene            complement(25126..25659)
                     /gene="queF"
                     /locus_tag="AC0DU4_000815"
     CDS             complement(25126..25659)
                     /gene="queF"
                     /locus_tag="AC0DU4_000815"
                     /EC_number="1.7.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0033739 - preQ1 synthase activity
                     [Evidence IEA];
                     GO_function: GO:0046857 - oxidoreductase activity, acting
                     on other nitrogenous compounds as donors, with NAD or NADP
                     as acceptor [Evidence IEA];
                     GO_process: GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preQ(1) synthase"
                     /protein_id="HIN4236805.1"
                     /translation="MKRQSALVVFSGGQDSTTCLFWAMQHYETVEAVTFAYGQRHHLE
                     IQINREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLCVESKSLKLYLFSY
                     RNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISINPYYNYGKQGTKYEGLA
                     EQRLFQHDLYPEKIDNR"
     gene            complement(25964..26278)
                     /gene="trxA"
                     /locus_tag="AC0DU4_000816"
     CDS             complement(25964..26278)
                     /gene="trxA"
                     /locus_tag="AC0DU4_000816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003004519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HIN4236806.1"
                     /translation="MAKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEE
                     LSEDVLKIVKMDVDENPNTARAFGIMSIPTLLFKKDGQVVKQVAGVHTAEQIKAIIAE
                     LS"
     gene            complement(26295..26516)
                     /locus_tag="AC0DU4_000817"
     CDS             complement(26295..26516)
                     /locus_tag="AC0DU4_000817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HIN4236807.1"
                     /translation="MIEITYIDASKNERTVTFESYEDFERSQQACLIGVADYYPVQKL
                     TYKGHNLDYHGTYGDIFFYLMKQDLSQYN"
     gene            complement(26615..26995)
                     /locus_tag="AC0DU4_000818"
     CDS             complement(26615..26995)
                     /locus_tag="AC0DU4_000818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HIN4236808.1"
                     /translation="MTYLEKWFDFNRRQKEIESLLEETIAQQSEQSLTLKEFYLLYYL
                     DLAEEKSLRQIDLPDKLHLSPSAVSRMVARLEAKNCGLLSRMCCHQDRRSSFICLTND
                     GQKTLASLQKTVEESLEAGLDFLI"
     gene            complement(27138..28091)
                     /locus_tag="AC0DU4_000819"
     CDS             complement(27138..28091)
                     /locus_tag="AC0DU4_000819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HIN4236809.1"
                     /translation="MSISQRTTKLILATCLACLLAYFLNLSSAVSAGIIALLSLSDTR
                     RSTLKLARNRLFSMLLALAIGVLAFHLSGFHIWSLGLYLAFYVPLAYKMGWEIGITPS
                     TVLVSHLLVQESTSPDLLVNEFLLFAIGTGFALLVNLYMPSREEEIQHYHTLVEEKLK
                     DILQRFKYYLSRGDGRNRAQLVAELDTLLKEALRLVYLDHSDHLFHQTDYHIHYFEMR
                     QRQSRILRNMAQQINTCHLAASESLILAQLFSKIAGQLSQTNPASDLLDEIERYLEVF
                     RNRSLPKTREEFETRATLLQLLREAKTFIQVKVDFYQKYRQ"
     gene            complement(28159..29370)
                     /gene="sstT"
                     /locus_tag="AC0DU4_000820"
                     /pseudo
     CDS             complement(28159..29370)
                     /gene="sstT"
                     /locus_tag="AC0DU4_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713440.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015293 - symporter activity [Evidence
                     IEA];
                     GO_process: GO:0015826 - threonine transport [Evidence
                     IEA];
                     GO_process: GO:0032329 - serine transport [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine transporter SstT"
     gene            29509..30069
                     /locus_tag="AC0DU4_000821"
     CDS             29509..30069
                     /locus_tag="AC0DU4_000821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008381 - mechanosensitive monoatomic ion
                     channel activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="HIN4236810.1"
                     /translation="MQKFIQAYIEKLDVTTIIENILTKVISLLLLLIVFYIAKKMLHT
                     MVQRIVKPSLKMSRHDVGRQKTISRLLENVFNYTLYFFLLYCILSILGLPVSSLLAGA
                     GIAGVAIGMGAQGFLSDVINGFFILFERQLDVGDEVVLTNGPITVSGKVVSVGIRTTQ
                     LRSEEQVLHFVPNRNITVVSNFSRTD"
     gene            30126..31034
                     /locus_tag="AC0DU4_000822"
     CDS             30126..31034
                     /locus_tag="AC0DU4_000822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046873 - metal ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HIN4236811.1"
                     /translation="MVLEKQLGNGCTWIDLDLGKLNKLEDLSEIYGLDKETIEYALDR
                     NERAHMDYHRESGTVTFIYNVLDVKKDKAYYETFPMTFIVEHRRLITISNTKNAYVIE
                     QMTRYLESHDTLSIYKFLFASLEIISNAYYPVIEQMDKSRDEVNDLLRQRTTKKNLFA
                     LSDLETGMVYLTAAAKQNRILLEHIQGHALYRSFDEIEREQFDDAMIEAHQLVSMTDL
                     ISQILQQLSASYNNILNNNLNDNLTTLTIISVLLAVLAVVTGFFGMNVPLPLTDEPHA
                     WLYISLASAGLWIVLSLLLRKIAKKS"
BASE COUNT         9813 a         5376 c         6411 g         9489 t
ORIGIN      
        1 ttatataatt tatttcatat tttgtaaggt cagtgtgaaa atatttaaat agacttcctg
       61 taaaaactgg atttaacgcc ctccatttgt caaattaagc tagacagtct taccaactca
      121 gaaaatacct gatgaggtat ttggtatcca aaggatttag gtgggatgtg atttcttgag
      181 gctgggaaaa agtctttaaa attaaaaaat gtataatatc aggtgttgga aaaactttga
      241 tactatgcgt tttattgtgg gaatatttat ttcattttct cctgaaattg agtttttacc
      301 cagcctaaaa ttcttgactg acttcgttga aatctgtctg ctttggcaag tcatgacacc
      361 ttaaaagtct atttgaatgt tcgttgagac accgctgtct tggacatcct agattcgcaa
      421 aaaagctctc actatcgtga tgattggaaa tatctttcca ttttgaaaac tcttttccac
      481 agtcaaacgt aatagattta aagaggttca ctagaaattg tgccagccac ccttggatgg
      541 attctgccat atcctttgcc ttacgactct tggtcttcaa actgacaatc aattgactat
      601 acctgttcgc tcacaaatag gagagaactt tttacgaaaa tctaatgaat atgccacaag
      661 aacattatac cgcaacgtgt actatttttg gttcatttta ctatagaaac tattgaagca
      721 cctgtacgaa aatatagtag attgaaacta gaatagtaca cctctacttc taaaacattg
      781 ttagaaatcg atttgactgt cccgatcgat tcgtcctgtt attatttcat tttactatac
      841 attatgaaaa aggggagata gaaagcaaac agccttgaaa tcaatgttga ctgcgattat
      901 gaacctgaat cagcccctca aaagggactg tatatgaatg aacgttacca gtgtttaaaa
      961 actaaagaat atcaggcact tttatcttcc aagggtagac aaattttcgc taaacgtaag
     1021 attgatatga aatctgtctt tgggcagata aaggtttgtt tgggttataa gagatgtcat
     1081 ctgagaggta agcgtcaagt gagaattgac atgggattca tactcatggc caacaacctg
     1141 ctgaaatata ataagagaaa gaggcaaaat taaaaagcta gagttccgca attgggaatc
     1201 tctagctttt tgttttctga gaatcatctt gactcagact cttttgacta atgttaccaa
     1261 aaaagataaa gtaactttta accttattta tcgtcgccac tcaacatgtt tttaacacct
     1321 tctacagcac cttctacagc gtctttagcg tcttcggcaa cttcttttac tttagaaaca
     1381 actttttcag ctgctccttc tttttccatt ttttcatcac cgatggcttt cccaacacct
     1441 tctttaatag aacctttagc ttgatttaat ttttcttcta ctgacatgat aatttctcct
     1501 gttatattta ttttatctta gtttacacga gtgttttcgt gagatactac accatttgct
     1561 gcacctttaa cagcttctac accttcgcta actttttctt gaacagttga gaaaccagat
     1621 ccaagaccag atttagcttt ttcgaattgt tctgaagtga attctcctgt tgattcagca
     1681 acgtcagata cgcgatcttg aaggcttact gagtctgctt catgctgttc tttagttttg
     1741 atgtcgacaa cgtttacgtt gatttcaaca atttccaagt cagtcatttt agcaacttct
     1801 gaagatacga tttctctgat ttctgaatat aaagctggaa catttttttg gtactcaaca
     1861 ataacgttta agtcaactgc aacttgtgtt ttaccaactt ctacgttaac accacttgtt
     1921 acgtcatcgc tgttaacgat tttttcttta agatttgaga agaaaccacc atcgattccc
     1981 aaaagacctg aaacgttttc tagtgaaaga ccaatgattt tttggataac tttatcttcg
     2041 taagtaagtt cccctttgat ttcgtgagct acaacagtag catctttctt ttctacgtta
     2101 gtgtttgtgt ttttttcgtt tgacatatga aactccttta attaaattag taatttttat
     2161 ttttttattt atctatatag tttttttcga tatataatcc agctgcaact cccagtgctc
     2221 ctaaaatcaa tacaaatatt gttttgaaga agccaaagga gacaatcaaa caagccagaa
     2281 atacgcctat gagaccagcg ataattggat atcgatattg tttaagccat tccatttttt
     2341 acttccttac ttcacacgac taacagtctt tttgttttga ggttttggtt ggtaattttt
     2401 tactgcaact tcaagtttta cttgacgctc aataccaaaa aactgcttca atccattagt
     2461 tatttcattt tgaattattt ggcatctgtc agcgatgttg tctgaaggaa gaattttacc
     2521 ttctacatga acgaaacatt tattttttcg taaatttaca tgaacagttg ggttcttgat
     2581 caatctatga tcactcacca aacttctaac aaaaccttcg attgccgaat tctttaattt
     2641 taatgtatcg tttttagttt caagttggat ttccaagtaa cgtttaggat aaaacatcac
     2701 aactaaaatg gataataaaa ctaaagttga tagaaccact gtcccccaaa agacatatct
     2761 agcaagatag aattcaacta cggagttctg tctccagcta agtagatgaa tacctagatt
     2821 actaacttga tgataatcta tcaaaacagg aaggaaaatt gtcaagatta aaatacagaa
     2881 aataatgaaa catattttct ttgcttttga catatacaat cctttcgatt taacatttaa
     2941 actatttttc ccgtcattga tttaaaaata gtttgctaac tttactggcg aaaagtttac
     3001 tttctacctg taaagaatga cactacagta atcacaatcg ctgcacctac aatagatggg
     3061 agcaaagcca ttccagcgat tgatggaccc caactaccta aaagagattg tcctgcatat
     3121 gccccgacta aaccagcgaa tacatttgcg atgattccca tagaactact tttttagtga
     3181 ttttacctgc caagagacca ataagacctc cagcaataat tgatcacaac actgcctacc
     3241 ctcctttttt attttaatat caaaaaatca atttctttga ttaatactat tatataactt
     3301 taatatagaa aagtcaatta tttcgattgt tattattata taattttaaa aaatcaaatt
     3361 ctttaattgt tgctattata taatttttaa aattaaaaat ataatcttta gacttgaatt
     3421 tgattctgta ttcacgccct caatagacgg taaaataaga aaattgttta tatattgtct
     3481 ccgtagtgtt attatacgaa ataaaagatt ttaggaaaag tcgttatatc atgctatacc
     3541 tattctttgt ggtataattg caagaggttt aatccgataa tttataaaga gagaaagata
     3601 ttcatgagag atttattatc taaaaaaagt cataggcaat tagaattatt agaattatta
     3661 tttgaacata aacgttggtt tcatcgttct gaactagcag agttattaaa ttgtacagaa
     3721 cgtgcagtca aagatgatct atcccatgtt aaatctgctt ttcctgactt gatttttcat
     3781 tcttctacta atggtatacg cattattaat accgatgata gtgatattga aatggtttac
     3841 catcatttct ttaaacattc aactcatttt tcgattttag aattcatctt ctttaatgaa
     3901 ggttgtcaag ctgagagtat ttgtaaagaa ttttatatca gttcatcttc gctctatcgt
     3961 attattagcc aaatcaataa agtgattaaa aggcaatttc aatttgaagt cagtctgacc
     4021 cctgttcaaa tcattggaaa tgagagagac attcgttact tttttgcaca atatttttca
     4081 gaaaaatatt atttcctaga atggccattt gaaaattttt catcagagcc actatctcaa
     4141 ttgttagaat tggtttataa ggaaacaagc tttccaatga atttgtcaac gcatagaatg
     4201 ctaaagttgc tcctagttac gaacctatat agaataaagt ttggtcattt tatggaagta
     4261 gataaagatt cttttaacga ccaaagtttg gattttttaa tgcaggcaga aggaatagaa
     4321 ggtgttgctc agagttttga atcagaatac aatatctctt tagatgaaga agttgtttgc
     4381 caattatttg tgtcttactt tcaaaaaatg tttttcatag atgaaagtct ctttatgaaa
     4441 tgcgtaaaaa aggatagtta tgttgaaaaa tcttaccatc tattgagtga ttttattgat
     4501 cagatttcag tcaagtatca gattgaaatg gagaataagg ataatctgat ttggcatctg
     4561 cataataccg cacatctgta tcgtcaagag ttgtttactg agtttatttt atttgatcaa
     4621 aaagggaata caatcaggaa ctttcaaaat atttttccaa aatttgtttc agatataaaa
     4681 aaagagcttt ctcactattt agagactctt gaggtttgtt ctagttcaat gatggtaaat
     4741 catctatctt ataccttcat cactcatacc aaacatttgg tgattaattt gctacaaaat
     4801 cagcctaaac taaaggtttt agttatgagt aattttgatc agtatcatgc aaaattcgtt
     4861 gcagagacac tttcttatta ctgtagcaat aattttgaac tggaagtttg gactgaatta
     4921 gaattatcaa aggaatcttt agaagattca ccttatgata tcattatttc taattttatt
     4981 attcctccta ttgaaaataa gagactcatc tattcaaata atataaacac ggtctcactc
     5041 atatacttgt taaatgccat gatgtttatt cgattagatg agtaaccaaa aataacaaaa
     5101 aaacgctatt tcgcgtttga actgtacctc aaaagttaga cagaaaaaat ctaatttttg
     5161 gggtgttttt gttaagaaaa gaccttcaat catttaagca aaatgtacat ctagatttat
     5221 agccctctaa aactcttgct ttttttgtag aagatacgaa aaaagccata aaaccaaggc
     5281 ttttcctgtt ttatgtagat gtttacacat gaaaattgaa gtattttcaa aagctaattg
     5341 gagtgatttt attcatgatg ggataaatga tctggccaaa aatgattgag aaatagttgc
     5401 ttaaaaagca tttgcatgat actatatatt gaaaggaggt gataatatgg tagaacaaag
     5461 aaaatcaatt accatgaaag atgttgcttt agaagcagga gttagtgttg gaactgtttc
     5521 acgtgtaatt aataaagaaa aaggcattaa agaagtaact ttgaaaaaag tggaacaagc
     5581 gattaaaact ttgaattaca ttccagatta ctatgctaga ggaatgaaaa aaaatcgaac
     5641 agaaacgatt gcaatcattg taccaagtat ctggcatccc ttcttttcag aatttgctat
     5701 gcatgtggaa aatgaagtct ataagagaaa taacaaatta ctcttatgtt ctataaatgg
     5761 tacaaataga gagcaagact atctggagat gttgcgtcat aataaagttg atggagtggt
     5821 tgccattacc tatagtccaa ttgaacatta cttgacgtca ggaattccct ttgttagtat
     5881 tgaccgcaca tactcagata ttgccattcc ttgtgtttca tcagataatg atgcaggtgg
     5941 aagagaagca gctaaacaat taattagtaa aggatgtcag catttagcct ttgtgggcgg
     6001 acataataca accattaatg aaaccaaacg tcgtagaatt tcatttgaaa agtatgtcca
     6061 agagcataaa atacctctta gtatttttga tttggatgag acagttactg actattatgg
     6121 aaagctagag agtttcttgg aagaaaattc ttctatagat ggaattttta caatcaacga
     6181 ttttacagct ttggatgtga ttgaaatact agaaaaaaat ggcaaacgta ttcctcatga
     6241 tgtccaaatt attggatacg atggaattaa aatggctgga gatagagatt atctactttc
     6301 aactattgaa caaccattgg aagaaatggc aaaagaagcg gttcgtattt tgtttgatat
     6361 aattgatgga aagactgtta atttgcagac aatcctacca gtaaaatttg ttgaaggaaa
     6421 aacaacaaaa aatgaaaata agtcttgaca gaaagcgcta tcaatgatag aatgaattca
     6481 gataaaaaga tttattttta aaacaaaaat gaaacgtttc aaaaaaagaa ataaaaagac
     6541 agcgccaagc gctatctttt atagaaaaaa tgaaacgttt caaaaaaagg aggttgctat
     6601 gaatagcaaa gcgaagcaag tttctctttg ggaaagaatc aagaaacaaa aactcttgtt
     6661 attgatgact gtccccggtt tagttttaac ctttatcttt aaatacatcc ctatgtatgg
     6721 ggttttaatc gcatttaaag attacaatcc tttaaaagga attttaggga gtgattggat
     6781 tggtttttct gagtttacaa aattcatatc ctctcccaac tttggtatct tgttagccaa
     6841 cacattaaaa ttaagtatct atggtttatt gcttggcttt ttaccaccaa tcattcttgc
     6901 gattatgctc aatcaactct tgagtgaaaa agtcaaaaaa cgaattcagc tcattttata
     6961 cgcaccaaac tttatctcag tcgttgttat tgtcggtatg attttcctct tcttttcagt
     7021 gggaggacca atcaacaatt ttctttctat gtttggaatg aaggctgact tcttgacaaa
     7081 tccagacttc tttagaccct tatacatctt tagtggtatc tggcaaggaa tgggctgggc
     7141 ttcaacgctc tacacggcaa cattggtaaa tgtagatcca gccttagtag aagcagctcg
     7201 actggatgga gccaatatct tccaacgaat ctggcacatt gatattccag ctcttaagcc
     7261 tattatggtt atccaatttg ttttagctgc aggtggaatt atgaatgtcg gatatgaaaa
     7321 agcattcttg atgcagacat cgttaaattt gccaacttct gaaattatct cgacatatgt
     7381 ctataaagtt ggtcttgtat caggagacta ttcttactca acagcggttg gtttgtttaa
     7441 tgcagtgatt aacgtagtat tgcttgttgc agttaaccaa atcgttaaac gcatgaataa
     7501 tggtgaagga atttaaggag gaaagtatga aaaattcgat tatggataca aaatttgata
     7561 gacgtatctt actcttaaat aaaatcatta ttgtctttat cgttttgatg actttgcttc
     7621 ctttacttta tatcgtcgta gcatccttta tggatcctaa ggttctggtt agtagaggga
     7681 ttagctttaa tccagccgat tggactgtag aaggttacca gcgtgtattc agtgaccaat
     7741 ctattctaag aggttttatc aattctctac tatactcttt tggatttgca gctttaacag
     7801 tattgctatc tgtgtttaca gcttatcctc tttctaagaa agacttggtt ggacgtcgtt
     7861 ggattaacta cttcttgatt gtgactatgt tctttggtgg tggtttagtc ccaacttact
     7921 tgctcgtaaa agaattggga atgctcaata ctccatgggc tatcattgtt ccaggtgctg
     7981 tcaatgtttg gaatattatt cttgctaggg cctatttcca aggattgcct gaagaattag
     8041 ttgaagctgc tgtcattgat ggagcgaatg acttgcagat tttctttaaa atcatgcttc
     8101 ctcttgcaaa accaattatg tttgttctct tcctctatgc ttttgtagga cagtggaact
     8161 catactttga tgcaatgatt tatatcaagg atccaaactt ggaaccattg caacttgtac
     8221 ttcgtaaaat tctcattcag agccaaccag gtcaagacat gattggagca caagcggcta
     8281 tgaatgaaat gaaacgttta gctgaattga ttaaatacgc aactattgtc atttccagct
     8341 tgccattgat tgttatgtat ccattcttcc aaaaatactt tgataaagga attatggctg
     8401 gttcacttaa aggataaaaa aagaaaaaat aaaaggagtt ttctcatgaa attcaaaaca
     8461 ttctcaaaat cagcagtttt gttgacagct agtttagcag tacttgcagc ctgtggctca
     8521 aaaaatacag cttcaagtcc agattataag ttggaaggtg taacattccc gcttcaagaa
     8581 aagaaaacat tgaagtttat gacagccagt tcaccgttat ctcctaaaga cccaaatgaa
     8641 aagttaattt tgcaacgttt ggagaaggaa actggcgttc atattgactg gaccaactac
     8701 caatccgact ttgcagaaaa acgtaacttg gatatttcta gtggtgattt accagatgct
     8761 atccacaacg acggagcttc agatgtggac ttgatgaact gggctaaaaa aggtgttatt
     8821 attccagttg aaaatttgat tgataaatac atgccaaatc ttaagaaaat tttggatgag
     8881 aaaccagagt acaaggcctt gatgacagca cctgatgggc acatttactc attcccatgg
     8941 attgaagagc ttggagatgg taaagagtct attcacagcg tcaacgatat ggcttggatt
     9001 aacaaagatt ggcttaagaa acttggtctt gaaatgccaa aaactactga tgatttgatt
     9061 aaagtcctag aagctttcaa aaacggggat ccaaatggaa atggagaggc tgatgaaatt
     9121 ccattttcat ttattagtgg taacggaaac gaagatttta aattcctatt tgctgcattt
     9181 ggtatagggg ataacgatga tcatttagta gtaggaaatg atggcaaagt tgatttcaca
     9241 gcagataacg ataactataa agaaggtgtc aaatttatcc gtcaattgca agaaaaaggc
     9301 ttgattgata aagaagcttt cgaacatgat tggaatagtt acattgctaa aggtcatgat
     9361 cagaaatttg gtgtttactt tacatgggat aagaataatg ttactggaag taacgaaagt
     9421 tatgatgttt taccagtact tgctggacca agtggtcaaa aacacgtagc tcgtacaaac
     9481 ggtatgggat ttgcacgtga caagatggtt attaccagtg taaacaaaaa cctagaattg
     9541 acagctaaat ggattgatgc acaatacgct ccactccaat ctgtgcaaaa taactgggga
     9601 acttacggag atgacaaaca acaaaacatt tttgaattgg atcaagcgtc aaatagtcta
     9661 aaacacttac cactaaacgg aactgcacca gcagaacttc gtcaaaagac tgaagtagga
     9721 ggaccactag ctattctaga ttcatactat ggtaaagtaa caaccatgcc tgatgatgcc
     9781 aaatggcgtt tggatcttat caaagaatat tatgttcctt acatgagcaa tgacaataac
     9841 tatccaagag tctttatgac acaggaagat ttggacaaga ttgcccatat cgaagcagat
     9901 atgaatgact atatctaccg taaacgtgct gaatggattg taaatggcaa tattgatact
     9961 gagtgggatg attacaagaa agaacttgaa aaatacggac tttctgatta cctcgctatt
    10021 aaacaaaaat actacgatca ataccaagca aacaaaaact agaggttgat tatgggagat
    10081 aagaaataca cagtagaaaa agccaatcgt tttatagcag aaaataaaca tctcgttaat
    10141 actcaatata agcctgaaga acatttttca gctgagattg gttggatcaa tgatccaaat
    10201 ggatttgtct attttcgtgg agaataccat ctcttttatc aattctatcc atatgatagt
    10261 gtttgggggc ctatgcactg gggacatgct aaaagtaagg acttggtgac ttgggagcac
    10321 ttgccagtgg cacttgctcc tgaccaagat tatgaccgaa atggttgttt ctcaggctct
    10381 gccattgtca aggatgatcg cctctggctc atgtacactg gacatatcga agaagaaacc
    10441 ggtgtccgcc aagtgcaaaa tatggcattt tcagatgacg ggattcactt tgaaaagatt
    10501 gaacaaaatc cagttgcaac tggatcagac ttgccagatg agttgattgc tgctgatttt
    10561 cgtgatccaa aactctttga aaaagatgga cgctattact ccgtagtagc tgccaaacac
    10621 aagaataatg tgggctgtat cgttctacta gggtccgata acctagtaga atggcagttc
    10681 gaatccatct ttttaaaagg ggtagaacac caaggcttta tgtgggaatg cccagattac
    10741 ttcgagttag atgggaaaga ttgccttatt atgtcaccca tgcgttatca gcgtgaggga
    10801 gactcatatc ataacatcaa ctcatcgctt ttgttcacgg gtaaggtaga ttggggagaa
    10861 aaatgtttta tcccagaatc agttcaagaa attgatcatg gccaagactt ctatgcgcct
    10921 caaacattgt tggacgatca aaatcgtcgt atcctgattg cttggatgca gacatggggg
    10981 cgtacccttc caacccatga ccaagaacac aaatgggcat gtgccatgac tttacctaga
    11041 attttaagat tggaagatgg caaactaaga caattccctg ttaaaaaagg ccaatatcaa
    11101 atccaaatag ataaagattg tcattaccac ttaggaaatg atatagatta tcttgaattt
    11161 ggttatgata gtaatgcgca gcaagtttac attgatcgta gccatcttat tcaaaaaatt
    11221 ctaggtgaag aagaacagga cactagtcga cggtatgtag atattgaagc taaagaattg
    11281 gaagttgttc tagataaaaa ttccatcgag atttttgtca atcaaggtga agcaagcttg
    11341 actgcaactt attacttaac ggtgccagct gagctatcac gaattgatta aaaattaagt
    11401 tatttctcct aaagaaaaag ttctctttct aaaatagtgg aaagaggact ttttgtgttt
    11461 tgggtatata agcttagttt atggtatttg taaaattggt gttggattat gatttaagct
    11521 agttttctaa agaatttgaa aaaaatttta tttaagcaaa aaaaaccctt ggttccaagg
    11581 cttttcctgt tgtatttata tgccccctac agggatcgaa cctgtgaccc acggattaag
    11641 agtccgctgc tctgccagct gagctaagga ggcaaagaaa aaagctgtat tggtgccgaa
    11701 acttcacggt ttgtattgaa cccgcgcaat taagcaggtg ggcaactcgc tctaactgaa
    11761 gctgtttccg tgtgagacgg cctacatgct gttagaagac ttttgtttcc ctaataatac
    11821 aaaaaatagt cggtcaacac ttaagtgtga agtcgtacac cacagcgttt ctatacttat
    11881 atgataccac tttttcaaaa aaaatcaaga ggaaagtgca attttttgaa aaggatttca
    11941 gatttttcgc aaacggtcga tagcttcctt tctttgagcc aaagcccgtt catatttacc
    12001 agtatcttct gcttggaaat agtgatgatt acgaattttt tctggcagat agtcttgctt
    12061 gacccaattt ccaggatagt tgtgtggata gagatagtct tgggcattcc ccagttcctt
    12121 gcttccactg tagtgcccat cacgtaggtg tcgcggaata ggcaagtgcc ctgatgtttt
    12181 gaggtcagca agtgccttat ccatagctac ataggctgag ttggattttg gagaaagggc
    12241 caaatcaatc acgacattgg caatgagaat gcgggcttct gggaacccaa tcttctgggc
    12301 agcatccaga gcagtcacgg tatgaatctg ggcctcagga ttggctaagc cgatatcttc
    12361 ataggcgata acagtcaagc gacgagcgag actaggcaga tccccagcct caatcaagcg
    12421 ggcagtatag tggagactgg catccacatc tgagccacga atagactttt gcagggcaga
    12481 tagaacatca tagtgaccgt ctccatcctt gtccatagtg atgtagcttc tctgaagact
    12541 attttccatg atgtctaagg tgatgtggcg aatgccctcg tcattctcag gggtagagag
    12601 aacagctaag tccagtgagt taaaggcaga gcgaaggtct ccgtttgtag aggttgcgat
    12661 gaaatccagc gcatcctcat ctagttctat tggaaaatca aaaccacgtt cagggttact
    12721 tagagctatc tgcagggcct ctttgacgtc ttggttagac agaggttcca actcgaaaat
    12781 ttgaactcgg ctacgaatgg caggagtgac agagaagaaa ggattttcag tcgttgctcc
    12841 aatcatgatg accagtccac tttccaagag aggcaagagg aagtcttgct tggtcttatc
    12901 tagtcgatga atttcgtcta gcaataggac gagaccacca gaaaatttag cttcttccga
    12961 gatttcttgc agtcgctttt tactatcaac tgtcgcattg aaagttcgaa aggcatactt
    13021 ggtcgttcca gcgatggcag aggcaatact ggttttgccg attccaggag ggccatatag
    13081 aatcatggag gacaggcggt tggcttccac catgcggcgg atgatttttc caggtccgac
    13141 cagatgctcc tgaccgatga cctggtcgat ggttttaggg cgcatgcgaa gcgcgagatt
    13201 gtctggcata gcagtccttt ctagcgtgga tttgagtaga atgactcatc tactatatct
    13261 tactatgtcc attctagcct attagttgtg atatttcaat ggttttgtaa taatcaggga
    13321 gtgagataga atctttttta ctatttaatt taatgaggag aggtatcagc atgagagatt
    13381 tgattttcct taaagctcaa aataggatag ttgagcctaa agaagtggaa gtgctgactt
    13441 gagaaataat attgctgaat gtcattgtat gaactataat gaaaagagag gtgataagca
    13501 atggaaatga tggaccaagt caggaaattt tgatttttac aaaacaaatt cgtcattgga
    13561 ttcttagtga tcaagttatt tcagggaaaa gaaaactttt cttccgggaa gatactccaa
    13621 aagagatttt agatttgtac gaaaacatta aatctaaact tgattttgct taccaataag
    13681 tttattctaa taatgggttg aaaaaatatg aaaaatagaa taattgatgt ttttgaagta
    13741 gtaaatcgca tccttgtaat aactgttgaa aatcctgatt tcgaagactt gagagttaat
    13801 catactcaat gaaaatcaaa gagcaaacta ggaaactagc cgcaggctgt acttgagtac
    13861 ggtaaggcga cgttgacgtg gtttgaattt gattttcgaa gagtatcagt ttgtaaaaat
    13921 tggagataaa aaatatagag tacgcagtgt tcctatgatt cattcaactc cgcctcaatc
    13981 tgtcttagat cgagatactt ttacaattga ctatacagat gatgaattgc tcgataaaga
    14041 agcagttttt actactcatt agaaaaatag gtctgaataa attggcttcc cttagaacca
    14101 catctagggg cttttatgta taatagaata ataagtatca ctcctttaca atacgtgtaa
    14161 cacgtgttat aatggtgttg tcaggaggta aaagcgctat gcctatgaca caaaaagaga
    14221 tggttaaact ccttacggcc catggttgga taaagactag aggcggtaaa ggctcccata
    14281 ttaaaatgga gaagcaaggg gaaagactta tcacaatccc tcatggtgag ctgaataagt
    14341 acactgaaag agggataaga aagcaagctg ggttgtaaaa ttcagcccct gttttttgat
    14401 atggaggtag tgaaatgtta gttacgtatc cagctttatt ttattatgac gacacagacg
    14461 gaacagaagc gacttatttt gtccatttcc cagattttga atactcagct acacaaggag
    14521 aggggatttc tgaggctttg gctatggggt cggagtggct agggataact gttgcagatt
    14581 tgatagagag tgatggagag ttacctcagc catcagatat caatagcttg tctttaattg
    14641 ataatgatcc ttttaaagat gatgaagatt tcgtgtcaac ctatgacctt gataaatctt
    14701 ttatttctat ggtatctgtt gatgtatcag aatacctagg aagtcaggaa cccataaaaa
    14761 agactttgac cataccaaaa tgggcagata agttgggacg agaaatggga cttaactttt
    14821 ctcagacttt gacagacgct attgcagata agaaagttca agcctaagat taagcgtggt
    14881 atcgtggtaa tagtcaataa aaaagcacgt ccacttgtgc tagttactcg cctattgatt
    14941 ttatagattt attagccctt tcgagggctt tttatattga tttttatgag aaatgaagaa
    15001 atcagacttt taagaaaatc actgatacca agggtttaaa tgaggtaata tggtataatt
    15061 aggacataaa ataattttgt ggtaagatgg tagtatctat tttagcatat ttccgagcaa
    15121 tcggggcgat taaagagtcg catagaaaga ggacaaaatg gcaacatacg gatttttaga
    15181 tgttttagag gaagagttgg acaagaactt tccctttgac tttgagatta gctgggacaa
    15241 acgcaaccat gcggtagaag tgagttttct attggaagcg caaaatgctg caggtgtgga
    15301 gatggtggat gaagacggag aggtttcatc agatgacatt ctttttgagg aagcggtcct
    15361 tttctacaat cctgccaagt caacagtcaa tgaggaagac tatttgactg ttattcctta
    15421 cctgcctaaa aaaggatttt cccgtgaatt tttagcttat tttgcgcttt tccttaaaga
    15481 tactgctgag gttgggctag atgtcctcat ggactttttg gaagacccag aagcagagga
    15541 atttatcatg gaatggaacc aagaagtctt tgaagaagga aaagttggct tggaagaggg
    15601 agaattttat ccttatccaa ggtattagaa aagattctaa gtggacattt ttaaataatg
    15661 aattcaagga gaagggggag attatgctag aaaaagtcaa acagtttttc aggagcaggt
    15721 cagctaaaac tgagccgtca gttgatattc ttccccgcaa tcgctttgag gatctagatt
    15781 tcgagagagt attgaagtca ggagctcgtc gccttgttaa tgaggaagga cgctatgctg
    15841 aggatgggaa aatcacagaa cttgaatttc ctgaagattt tgcggaattt gaatttctag
    15901 ttggttttaa gacggaggaa gaagagcagt ttcagcaact attagctcgt ttaaatagta
    15961 ttgacaatgc tattcagtcc tatttggaaa gtgagatgca acaacccatc cctcagtatg
    16021 ccaaggatct cggctatact cagaagaggt gggagaaaac cttttacttc catcattgga
    16081 tattaagtgg tgaggaaaac ccgcctaatc ttcgctatgt tgcagattat gtaaatgatg
    16141 agtttacggt ttattttgct aaaaaacatg gcagatggca agcatactgg gatgcagagt
    16201 gccaaaaagt aatcgaagaa agctagctcg tattttccta gagagtaatt gttatcatag
    16261 aaaagagtaa atatcatgga attattgaat agcagaatgg atttccaagg ttgcaagatt
    16321 gccctctttt gtggggataa gctactgacg attttgcgtg atgacaagga cgatatccct
    16381 tgtcccaaca tgtgggagtt gccaggtggg ggaaagagtg tcagggaaaa tctgatatag
    16441 ttttgcatta aaagaatatc ctttcaaggt tattcttttt taattttgtc ccaaaataat
    16501 tgactttgtc ccaaaaatat agtattattt gtataaggag gaatgaatca tgaaaaaatc
    16561 agatgttctt gatttaataa agtatcatta tgagggcaga gagacagaat ttagaaatca
    16621 atccatagca attgctcgga acttcaataa acatggtgat acacaaatag cacaatatat
    16681 tatggggtta atgtctcaaa gtgatagatt catgccacaa atagaaaatc ctagtgagta
    16741 tttgactcct gctaaactag atattggtcc tctcccattg cctctttcaa ttatgaatga
    16801 tttaaaagga ataataaacg ctgtcaatca tcatattgga ataaataaat ttttatttgt
    16861 gggatctcca ggtactggaa aaactgaaag tgtaaagcag gtggctagac ttattggcaa
    16921 ggaattactt gtagtagatt tcagtcactt agtagatagt aagctagggc aaacagtcaa
    16981 aaacttagca actcttttta atgaaatcaa taatcttcct ttcaagcaaa attatatcat
    17041 cctatttgat gaaattgatt ccatagtgtt ggatagggtt aatcagaatg atttaagaga
    17101 aatgggacga gtgacttctg cctttttaaa ggagttggat aggctgtcac cagaaattgt
    17161 attaattgca acaacaaatc tttttgaaaa tcttgataaa gcagttacga gaagattcga
    17221 tgccataatt gactttgacc gttatactga tgaagataaa gtagaagtag ctactattat
    17281 tttaaatgag ttattaaagc aatttaagaa tgtagctaga gatttaaaat tatttaaaaa
    17341 aattatcaat agtgccaatg taataccgaa tcctggtgat ttgagaaact caataagaac
    17401 gtcattggca tttagtgacc catcagatcc gcatgattac caaaaacgcc tgctaagaag
    17461 tttgcataat ggtagaaatt tatctatttc taaattatcg aagctaggtt ttactgttag
    17521 agaaattgag attttgacag gtatttctaa gagtagtgta tcacgagagt taagcgagga
    17581 ttaaaatgaa tacattattg acattacgag gtaaaagttt tacaccaaag tcagcaaagg
    17641 ggaggggacc gataacgatt cccgcagatt ctattgttac gctaaaccat ttaaatgaac
    17701 tttatacatc ccttgaacga gtaaaagaat attggtctaa taacacaatc attgatggag
    17761 tacttattag tgtgtattat aatcgtgtcc tagctaagag caatcgtatc gatggttttt
    17821 ttaatgtggg tggcggaaat gcaattccaa atgaaacgat tgtgggtgca aaatttagta
    17881 atgataagag taggcatatt attacacact acatttcaaa ggaagtgtta gataagacaa
    17941 ttgagcatac taaaaaagtt ataacaatat tcaaagatta ttttgctagt gctcccatga
    18001 cgagtatggt gttctccgac tcttcaaaat ttaatcaaat tgattattct aagtatggtc
    18061 tgtcgaaatc aaaattcaaa caatacttaa gagacgcttg ctttgtcaaa ggatttggta
    18121 ttgaacaggc agatatgtct actatacgta attctattgt aacaatctac gatgtaaaaa
    18181 ctaatctctt aacattactt aaacaacttg atattgatgt ttcagaagct aacatcatgg
    18241 accagacaac tgttttactt gacgaaaaaa atattgagtt actactgcta aaagcacctt
    18301 atctagtatc aatgatagta gaagattttt ctagcctgtc accagagaat ttttataatg
    18361 atgggaacac tttttataat aatctccctt ttccaactaa tgaacctatt attggtgtca
    18421 tcgatacgtt gtttgatgat agagtttatt tcaatgagtg ggtagagtat catgatttaa
    18481 tttcaccaga tattagcaaa ggaagtcaag actataagca cggtacagca gtttcctcgg
    18541 taatagtaga tggagctagt ttgaatccaa aactagatga cggatgtgga agatttagag
    18601 tcagacattt tgggatatct ttacagagtg gtttcaattc cttcacaatt atcaaacaga
    18661 ttagagaaat tgtgtctcaa aatcctgata ttaaggtttg gaacctttcg cttggatcaa
    18721 atgatgaaat tagggaaaac tttatttctg tcgagggttc gttgttagac gagattcaat
    18781 ttgataacga tgtaattttt attattgcag gcactaatgg gattgcccct gatggacaac
    18841 gaaaaaagat tggagcacca gcagattcac tcaattcaat tattgtaaat tctgttgatt
    18901 ttagcaatca agtcgtttct tattcacgcg aaggagttgt cctgtctttc tttatcaaac
    18961 ctgatgtttc atactatggc ggggggaacg gagacttcat aaatgtttgt gaaccactag
    19021 ggctggctcg agtagctggg accagttttg cggctccatt tattgctaga aaaatggctt
    19081 acctcattca tattatggga ttaagtcgtg aagaagcaaa ggctttatta attgattcag
    19141 cgataccatg gaatgataaa aaaacattcg cagacatttc tttacttgga tatggggttg
    19201 tgccaatcaa aatagaagat attttgtcta cacctgatga tgaaattaaa tttatagtct
    19261 cagatgtttc tagagcatat gaaacttata attatgattt cccagttcca atttctaaag
    19321 aacactatcc atatgtagca aaggccacta tgtgctattt tccaaagtgt tctagaaatc
    19381 aaggagttga ctatactaat acggaaatgc aacttagttt gggagtttta gataagaaag
    19441 gcattaaaac aattaataac gacaatcaat attctgaaaa tgcaccagga tatgtgagag
    19501 aaaagtcggc acgaaatatt tttaggaaat gggataatgt caaacattta ggagaaaaat
    19561 tttcttctcg taaaaaagct aagccgattc tgaatccttc taatcctcaa tggggaatga
    19621 gtgtaaaaac aattgaacgg ttaagaaatg atgatggtta tggtatccgt tttggagtag
    19681 ttgttactct aaaggagttg aatggtgtca atagaatcga agattttatt caacaagccg
    19741 aattacgcgg ttggctagtt aatagattgc aagtagaagc tcaagtagac ctctttaata
    19801 gtttaaatga agaaattgaa tttgaatagt ggatatttta tccttattct agatcttagg
    19861 aacacaagag ggcaaagata tgaatattac ttatatagtt ggaaatggtt tggatttgca
    19921 atatggtttg aaaacaagat ataaagattt ctatgaattt caaaatagga cttacataag
    19981 taggaaagag aacgaggaag aatattcaaa tctcatttat gagtctctat tttctgatac
    20041 agtaaatgat tatgaaaatt ggtcagattt tgaattgtca attggtaaat taacaaaaga
    20101 taacgacctc atctcctcaa gtatagaaat aaaggagaaa tttatagatg attttagtga
    20161 aatagttgat gatttaagag aatatctacg catacaacaa gaaaaaaatc ttgagaaagg
    20221 taatgcaatt gactttataa gcactctaga taatatgagg acctctctcc ctgtaattaa
    20281 tcaacctgct atcgataaaa aatataatga aaatctatat caacacgata tcgtgaatat
    20341 attaactctt aattacacaa atgtaatcga taaattatat aatgagtcag caaaatcatt
    20401 tagcaatcaa ttacgaacta ataattataa atttcacatt gcgcctccaa ttcatgcaca
    20461 tggaacggta gatatttgca cagttttagg agttagtgac gagacacaga tttcaaatag
    20521 ttttgatgaa gaacaaaaag aatccttaat aaaaaattta gttttgaaga actatagaga
    20581 aaatatggat gttaaaaata gcgatattat aaaaaattct gacatcataa ttctttatgg
    20641 ggtttctttg ggagagactg atgggtatat ctggaatcag attgctgaac aatcaatcag
    20701 aagttctgtt cctgtcataa tttaccatta tgtacctcat tttgatgcag gaaaccccac
    20761 tagagtaaaa cgcttatata gaaatgtaga agacaaattc atacaaaata gtggaattga
    20821 tttagagtta gagaagaaat taagagataa ccttattgtt gttattggaa agactatttt
    20881 taatctgatg gaaaggtaag caaaatacat aatggaaaca tggcaagagt taaaagttac
    20941 agtgaagcgt gagggagagg agttggtttc caatctcttg attgagctgg gagcgcaagg
    21001 agtcgcaatc gaagacagta tggactatgt gggaaatgtt gaccgctttg gcgagatttt
    21061 cccagaggtg gagcagcaag aagaaatcgt agtgacagcc tactaccctg acacggtgga
    21121 tgtgacagtg gttgaggcgg atttgcaggc tcgtctagca gaattgacag attttatgga
    21181 tttgggagag ttaaaaatag gtacgactgc cttggctgag gaagactggg cagacaactg
    21241 gaagaaatac tatgaacctg ctcgcatcac tcatgatttg accatcgttc cctcttggac
    21301 agactatgag gcgactgcgg gagaaaaaat tatcaagctg gatcctggca tggcttttgg
    21361 tacgggaacc cacccaacta ccaagatgag catttttgcc ttggaacagg ttcttcgtgg
    21421 tggcgaaacg gtgctagatg tgggaactgg ttcaggggtt ctctctattg ccagctcgct
    21481 tctgggggct aaagaaattt tcgcctatga cctggatgat gtggcagttc gtgtggctca
    21541 ggaaaatatt gagctcaacc ctggaatgga aaatatccat gtagtggcag gcgatttgct
    21601 taaaggcgtg gagattgaag cagatgtcat cgtggcaaac atcttggcgg atatcctcat
    21661 tcatctgaca gaggatgctt atcgcttggt taaggatgaa ggttacctga tcatgagtgg
    21721 cattatcaag gataagtggg acatggtgcg cgagttggct gaatcagctg gatttttcct
    21781 cgaaactcac atggttcaag gggaatggaa tgcctgtgtc tttaagaaaa ccaaggatat
    21841 ctctggtgtg attggaggct agcatgcagc agtattttgt aaaaggcagt gctatctctc
    21901 ctgtcactat cgagaacaag gaaaccagta agcatatgtt tcaggttatg cgcttgaaag
    21961 aagaggatga ggttacctta gtctttgatg atggcatcaa gcgcttggcg cgcgtgctgg
    22021 atatggaaaa tcgtcagttt gagttggtcc aagaattaaa tgacaatgtg gaactaccag
    22081 tccaagtgac catcgcatct ggatttccca agggagacaa gctggagttc atcgctcaaa
    22141 aagtaaccga actgggtgct agccaaatct gggcctttcc tgcagactgg tcagttgcca
    22201 agtgggatgg caagaaattg ggtaaaaaag ttgaaaaact agaaaaaatt gcccttggag
    22261 cagccgagca aagcaagcgt aatattgtac caagtattaa acttttcgag aaaaaagcag
    22321 attttctagc tcagctggac cagtttgact ctatcatagt agcctatgaa gaatcagcta
    22381 aagaaggaga agccgctgcg cttctgcaag cagtcactgg tcttgaaaca ggagccaaac
    22441 tgctctttat ctttggtcca gaaggcggtc tctcacctgc agaaatcgaa agttttgaag
    22501 ctaagggagc cgttttggca ggcctaggtc ctcgtatttt gcgagcagaa acagcaccgc
    22561 tttacgcttt atcagccctt agtgttttag tagaattaga gaaataagag gaagaaaatg
    22621 gaacaaaaac accgttcaga atttccagag aaggaactct gggacttaac agccctatac
    22681 caagaccgtg aggatttctt gcgtgcaatc gagaaagctc gcgaagacat caaccagttt
    22741 agccgtgatt acaagggcaa tcttcacact tttgaggatt tcgagaaggc ctttgcggaa
    22801 ttggaacaga tctacattca gatgagccat attggcaact atgcttttat gcctcagacg
    22861 acggactata gcaatgacga atttgccaat attgcccaag ctgggatgga atttgaaaca
    22921 gctgccagcg tagccttgac cttctttgac gatgccttgg tggcagcaga cgaggaagtc
    22981 ttggaccgtt tgggtaaatt gccacattta acagctgcca ttcgtcaggc taaaatcaaa
    23041 aaagcccact acttaggggc agatgtggag aaggccttga caaatctcgg tgaagttttc
    23101 tatagtccgc aggacattta tactaagatg cgagctgggg attttgaaat ggctgacttt
    23161 gaagcccatg gcaagaccta taaaaacagc tttgtcacct atgagaattt ctaccaaaat
    23221 cacgaggatg ctgaggttcg tgagaaatcc ttccgttcct tctcagaggg acttcgtaag
    23281 caccaaaata cggctgcagc agcctatctg gctcaggtca agtctgaaaa actcttggct
    23341 gatatgaagg gatacgactc tgtctttgac tatcttctag ctgaacaaga agtggaccgt
    23401 gtcatgtttg accgccagat tgacctcatc atgaaggact ttgcaccagt cgctcagaga
    23461 tacctcaagc atgttgccaa ggtaaatggt cttgaaaaga tgacctttgc agactggaaa
    23521 ttggacttgg acagcgccct gaatcctgaa gtgactattg acgatgccta tgatttggtc
    23581 atgaagtcgg tagaaccttt ggggcaagaa tattgtcagg aagttgctcg ttaccaagaa
    23641 gagcgctggg tggattttgc tgctaacagt ggcaaggatt ccggtggtta tgcggcggac
    23701 ccatatcgcg tacaccctta tgtactcatg agctggacag gccgtttgag cgatgtctat
    23761 accttgattc atgaaatcgg gcattctggt caattcatct tttcagacaa tcaccaaagc
    23821 tatttcaacg cccacatgtc gacctattat gttgaagcac cgtcaacctt caatgaattg
    23881 ctactcagtg attacttaga gaaccagtct aatgacccac gtcaaaaacg cttcgctctg
    23941 gctcatcgct tgacagacac ctacttccat aatttcatca cccacctctt ggaagccgcc
    24001 ttccagcgta aggtgtatac attgattgaa gaaggggaga cctttggagc aagcaagctc
    24061 aacagcatta tgaaggaagt tttgacagat ttttggggcg atgccattga aatcgacgac
    24121 gatgcagctt tgacttggat gcgccaagct cactactata tgggcttgta tagttacact
    24181 tactctgctg gtcttgtcat ctcgacagct ggttaccttc atcttaaaaa ctcagaaact
    24241 ggagctgaag actggctcaa tctcctcaaa tcaggtggta gcaagacacc acttgagtca
    24301 gccatgatta tcggtgctga tatttcaaca gacaaaccac tccgtgatac catccaattc
    24361 ttgtctgaca cagttgacca gattatcgcc tacagtgctg agttggggga gtaaggggat
    24421 agagaggttg ttatagaatg ggtatggaca gttatttgct taaaagtcca tgtttaaatc
    24481 ccccattcct tttcgaggaa ttctttgccc ttctctgtaa tggtaagtga acgtggcgtt
    24541 tgtgcaggga tgaccaattg tttttcactg aaaaattcta aaagagcatt gccgagagct
    24601 ccgccgacat gatttttacg ttcgctccaa tccaaacatt tagggcaaaa tttccgtttt
    24661 ttctttttca attcatccgt atcaatgtgt aattttcttt ggaaataaga cttcccagct
    24721 tcagtgagtt ggaagtcttt ttctgatcgg attgaagatt actggacttt cagtaaaccc
    24781 agctcgtagc ttggcaccag ctgtcttggt gggcggcgca gcccttcaac aagtttggat
    24841 tttcatcctt gcaccaatcg ctggtggagt tcttgcagcc cttgttgcaa aaaatttcct
    24901 tggaacagaa gaataattga aactcaaaaa gccttgctcc tcatcttgag gaacagggct
    24961 ttttcgtatg atactcttcg aaaatctctt caaaccacgt cagcttcacc ttgccgtagg
    25021 tatggttact gacttcgtca gttctatcca caacctcaaa acagtgtttt gagtaacctg
    25081 cggctaactt cctagtttgc tctttgattt tcattgagta tgactttagc ggttgtcaat
    25141 tttctctgga taaaggtcgt gttggaagag gcgttgttct gccaagccct catacttagt
    25201 tccttgctta ccgtagttgt agtaggggtt gattgaaatg ccaccgcgcg gagtgaattt
    25261 cccccagact tctaaatagc gagggtctag caagttgacc aagtctttcc cgatggtgtt
    25321 gatacagttt tcgtggaaat ctccgtggtt tcggtagcta aatagatata gtttgaggga
    25381 ttttgactcg acacagagtt tgtcaggaat gtaggaaata tgaatcgtcg caaagtctgg
    25441 ctgagcagtg atttgtccca gcagagacat atcgaggata tggtgacgaa tgccctgttc
    25501 cttagcgatt tctctattaa tttgaatttc gaggtgatga cgttggccgt aggcaaaggt
    25561 gacagcttcg actgtttcat agtgttgcat ggcccagaaa aggcaggttg ttgaatcttg
    25621 accaccacta aagacgacca aggctgattg acgtttcata gtactccttc caaaatggga
    25681 aatgttcaga gcatgcaaaa agctcccatt agggagctaa aaaataccaa atcgagtttt
    25741 tttagcgatg gcatatccca aacatcgtaa tattctactt atatagtaaa atgaaataag
    25801 aacaggacaa atcgatcagg acagtcaaat cgatttctaa caatgtttta gaagtagagg
    25861 tgtactattc tagtttcaat ctgctatagt ctagcatatt ttttgaaaaa tggcaaaggg
    25921 caagaaaaaa gagaccaaag aaagtacttg gtctctcgtt tgattagctc aattcagcaa
    25981 tgatggcctt gatttgttct gctgtgtgaa cacctgcaac ttgtttgaca acttggccgt
    26041 cttttttgaa gagaagagtt ggaatagaca tgattccaaa agcacgagct gtgtttggat
    26101 tttcatcaac gtccatttta acgattttca agacatcttc tgaaagttct tcagacaatt
    26161 tgtccaagat tggaccttgc atacgacatg gaccacacca agttgcccag aagtctacta
    26221 agaccaaacc gtcttttgtt tcttgttcga atgttgcatc tgtaattgct tttgccattg
    26281 tatttctcct ttttttagtt atattggctt aaatcttgtt tcatgagata gaagaagata
    26341 tctccataag tcccatggta gtccaaatta tgacccttgt aagttaattt ttggacaggg
    26401 tagtagtctg cgacgccgat aaggcaagct tgttgcgaac gttcaaagtc ttcataagac
    26461 tcgaaagtca cagttctttc gttcttgctg gcatctatat aggtaatttc aatcatgttt
    26521 aaaactcctt tgtttaatgc taactttatt ttactcctta taaaagagaa tgtcaagaaa
    26581 aatgattgcg cacgcaactt tttttaaaat catcttaaat caagaaatcc aaacctgctt
    26641 ccaagctttc ttcgacagtc ttttgtagcg aggccagtgt cttttgccca tcatttgtca
    26701 ggcagataaa actagagcgt ctatcttgat ggcaacacat gcgactgagt agaccgcaat
    26761 ttttagcttc caagcgagcc accatcctag aaactgcgct cgggctcaga tgaagcttat
    26821 ctggcaggtc aatctggcgt agagattttt cttcagccaa gtccagatag tagagcaggt
    26881 agaactcttt caaggtcaga ctttgctcgc tctgttgggc aatggtctct tccaagagac
    26941 tttcaatttc tttctgacgc cgattgaagt caaaccattt ttccaaatag gtcatagtgt
    27001 ctcctttctt tttagagtca taaatagaag aaagtccatt aacgggcagt ctctgcgtca
    27061 caagatgatt gcgcatgcaa taattatact acttttcaag aatgctggca agctctgttt
    27121 tttagtggtt ttatttttta ctgtctatat ttttggtaaa aatcaacttt tacttggatg
    27181 aaggttttgg cttcacgtag gagttgaaga agggtggcgc gggtttcaaa ctcttctctt
    27241 gttttgggca gactgcggtt ccggaagact tccagataac gttcaatttc atctagcaaa
    27301 tcagaagcag gattggtctg gctcagttga cctgcaattt ttgaaaagag ttgcgctaag
    27361 atcaggcttt cactggcggc aaggtgacaa gtgttaatct gttgggccat gtttctcagg
    27421 atacgacttt gtcgctgtct catctcaaag tagtggatat ggtagtcggt ctggtgaaag
    27481 aggtggtcag agtgatccaa atagaccagt ctgagggctt ctttcaaaag cgtgtctaat
    27541 tctgctacca gctgtgctcg gttgcgtccg tctcctctgg ataaatagta tttgaagcgc
    27601 tggaggatat cttttaactt ttcttccacc agcgtgtggt agtgctggat ttcctcttct
    27661 cgtgaaggca tatagagatt aacaagcaag gcaaatcctg taccaatagc aaagagaagg
    27721 aattcgttga ctaggaggtc tggagaggtt gactcttgaa ccaagagatg gctaaccaaa
    27781 accgtgcttg gtgtgatgcc aatttcccag cccatcttgt aggctaaagg aacgtagaag
    27841 gccagataga ggccgagact ccagatatga aatccgctca agtgaaaagc tagaacaccg
    27901 atagccagag ctagaagcat agaaaaaaga cgattgcgag ccagttttaa agtacttcta
    27961 cgcgtatcag ataggctcaa gagagcgata attccagccg aaactgctga cgaaagattg
    28021 agaaaataag caagcaggca ggcaagacag gtagctaaga tgagcttggt cgtacgttgg
    28081 ctaatagaca taagaatttc ctaataagtt agaataaaag cgtaaaagac aagacatgag
    28141 caggcttgcc ttgatgagtt attttttacg ggttgctgcg tattcggcaa cggcggtaaa
    28201 gaggacatct gtagaagaat taagggctgt ttcacatgag tcttggatga caccaatcac
    28261 aaaaccaacc ccaacaactt gtatggcaat atcgttagaa ataccgaaaa ggctacaagc
    28321 aactgggata agaaggaggg aacctccggc aatacctgaa gcaccacagg ctgagatagc
    28381 tgctaccaca ctgaggacaa aggctgtggc aaagtcaaca ggaattccaa gagtgttaac
    28441 tgcagcaagg gtcaaaaggt taatggtaat cgctactcca gccatattga tagtagaacc
    28501 gagtgggata gaaacagaat aggtatctgg gttgagtcca aggtcatggc agagtttcat
    28561 gttgacagga atgttagtcg cagaactacg agtgaaaaag gctgtcacac cgctgacacg
    28621 gaggcagttc caaactagag agtaaggatt gcgtctcata aagaagaagg caatcaaagg
    28681 gttgaccaca ggggcaacaa aaagcatagt cgttactaat ggaaccaata aaataccgta
    28741 gttggcaagg cttccgactc ccttgtcaga aatggtttta aaaacaagac caaggattcc
    28801 aaatggagcc agattgatga tccattcgac aattttagaa gtcacgtcag cgatagtttt
    28861 tagcaattct ttactatttt tactggcttc tctcatagcg attccaaaaa tgactgccca
    28921 agataagatt ccaatatagt tagcagtaaa cagggcgcgt tgactgggct gtcaaccagt
    28981 ttgagcaaga ggttgctgag gatctgccca accccatctg gtggtgcaat ttcagtattg
    29041 gcactattta gggtaatttc aatagggacg atgaaacttg ctagtacagc tacaagagca
    29101 gcggcgaaag tccctatcat aggatataca agaaaacaac agttttcata ttgctatctt
    29161 gtcccttttg atgttgggaa agggcattgg caacgagggc aaagactagg ataggagcaa
    29221 cagcttttag acctccaacg aataaatccc cgagtagccc aatccctgag agattaggaa
    29281 gggtcagtcc taggattccc cacaaagcat accaatcaag atacgcttga caaggcttgc
    29341 cttattccaa gcatgaatga ttcttttcat aataatctcc tttttgtgta gtgattatga
    29401 ttatagtata aatgatagac aaaatcaaga attttctgtc tattttttga atatttatgg
    29461 agaatgagac tgatgaaaat atggtataat gaaataaagg agttttatat gcaaaaattt
    29521 attcaggctt atattgaaaa gctagatgtg acaaccatta tcgagaatat tctaaccaag
    29581 gtcatttctc ttttactgct tttgattgta ttttatattg ctaaaaaaat gcttcatacc
    29641 atggtgcaga gaattgtcaa accttctcta aaaatgtctc gtcatgatgt tggacgccaa
    29701 aaaaccatct cacgtttact agaaaatgtg tttaattata cgctatattt ctttttactc
    29761 tactgcattt tgtcgatttt aggtttgcca gtttctagtt tgctggctgg agctggtatt
    29821 gctggggtag cgattggtat gggagcccaa ggctttctgt ctgatgtcat caatggcttt
    29881 ttcatcctct ttgaacgtca actggatgtg ggagatgagg tcgttctgac aaatggaccg
    29941 attactgtat cgggtaaggt tgtcagtgtg ggaattcgta cgacacagct tcgtagcgag
    30001 gagcaagtcc ttcactttgt ccctaaccga aatatcacag ttgttagcaa tttctcacgc
    30061 acagactaga cctgttattt taagtaattt gtggtacaat agagggagtt taataaggag
    30121 aaaagatggt tttagaaaag cagttgggca atggttgtac ctggatagac ctagacctag
    30181 gaaagttgaa taaactagaa gacctttctg aaatttacgg tttggacaag gaaaccattg
    30241 aatacgcact ggatagaaac gagcgcgccc acatggacta ccaccgtgaa agtgggacgg
    30301 ttacctttat ctataatgtc ctagacgtaa aaaaggacaa ggcctactat gagacttttc
    30361 ccatgacctt tattgtcgag catcgtcgcc tgattaccat tagtaatacc aagaacgcct
    30421 atgtcattga acagatgact cgttatctgg agagccatga cacgctttcg atttataagt
    30481 ttctctttgc cagtctggaa attatcagca atgcctacta tcctgtcatt gagcagatgg
    30541 acaagagtag ggatgaggtc aatgacctct tgcgccagcg aactaccaag aaaaacctct
    30601 ttgccctgtc tgatttggag actggtatgg tttatctgac ggcagctgcc aaacaaaatc
    30661 ggattttgtt agagcatatt caaggtcatg ccttgtatcg tagttttgat gagattgaga
    30721 gagaacagtt tgatgatgcc atgattgagg ctcatcagct ggtatccatg acagacctaa
    30781 tctctcagat tttacagcag ctttcagcct cttacaacaa tattctaaac aataatctga
    30841 atgacaattt gacaaccttg actatcattt cagtcttgct agctgttttg gcagtcgtga
    30901 caggcttttt cggaatgaat gttcccttac ctttaacaga tgagccccat gcttggctct
    30961 atatcagttt ggctagtgca ggtttgtgga ttgttttatc cttgttacta aggaaaattg
    31021 cgaaaaaaag ttaagaaaag gagccagaat ggcgattgaa aattatatac cagattttgc
    31081 tgtggaagc
//
LOCUS       DBMVGT010000016        31087 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.016, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000016 DBMVGT010000000
VERSION     DBMVGT010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 31087)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31087)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31087
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.016"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1138)
                     /locus_tag="AC0DU4_000823"
     CDS             complement(<1..1138)
                     /locus_tag="AC0DU4_000823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000949621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HIN4236812.1"
                     /translation="MLSLDQIHLLLNTPEDEFHDFKQKWHHSKTELVRDILNFVNTSH
                     HEDCYIIFGIDNITLDIIGVNNDDNRRNEEDLTDLLHKLFISTNNQIKISIQTETIDN
                     KEIDILIIHDTDKVPVFLTKDYKPKKDTALPKGLIYAINGSINTPKDSSAPFELINEL
                     FQKFNHTDLNIKEQYFHVLKDYKNWFFIENEDGRFFIYNPNPDFYIKLNDDDANRFKT
                     MSYSLNQYQTNIDWQLVQLRYRHLTIDECMAMYLDQGNCLVPSPEVESFKIDYQETIY
                     YHCLYKNTLKYQLLKVFSSIPGLEKYPLTRFKNSIVIYDTKLELKKTHNLINSKFSSK
                     DIVNQLEVTEKDFDFYYKKARHKNPDYSIQENQVNLTELNLVRLL"
     gene            1500..1856
                     /locus_tag="AC0DU4_000824"
     CDS             1500..1856
                     /locus_tag="AC0DU4_000824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012775541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAG1252 family conjugative relaxosome accessory
                     protein"
                     /protein_id="HIN4236813.1"
                     /translation="MKRDVRDIRKQFRLTEAEEKQILALMRERGETNFSDFLRKSLLS
                     SDLQKQMETWFALWQSQKLEQISRDVHEVLILAQSERQVTQEHVSILLTCVQELIQEV
                     ANTIPLSKEFREKYMR"
     gene            1861..2226
                     /locus_tag="AC0DU4_000825"
     CDS             1861..2226
                     /locus_tag="AC0DU4_000825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000263054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="HIN4236814.1"
                     /translation="MEHRYRTNLKKVFLSDSELNQLNINIDQSGCKSFSEYARRTLLD
                     PGMNFITIDTNGYQDLVFELKRIGNNINQIARSVNQSQLIPGEELQELKKGIGELIKE
                     VDKEFNLQAQKLKEFHGHH"
     gene            2213..4036
                     /locus_tag="AC0DU4_000826"
     CDS             2213..4036
                     /locus_tag="AC0DU4_000826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002917262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAG1250 family conjugative relaxase"
                     /protein_id="HIN4236815.1"
                     /translation="MVITKHFAIHGKSYRRKLIKYILNPEKTNNLALVSDYGMKNFLD
                     FPSYEEMVQMYHENFISNDTLYDFRHDRMEENQRKIHAHHIIQSFSPEDHLTPEQINR
                     IGYETVKELTGGKFRFIVATHVDKDHLHNHIIINSVDSNSDKKLKWDYKVERNLRMIS
                     DRFSKIAGAKIIENRYSHQRYEVYRKTNHKYELKQRLYFLMEHSRDFEDFKKNAPLLH
                     VEMDFRHKHATFFITDSTMKQVVRGKQLNRKQPYTEEFFKNYFAKREIESLMEFLLLK
                     VENMDDLLQKAKLFGLTINPKQKHVSFQFAGVEVKETELDQKNLYDVEFFQDYFKNRK
                     DWQAPETEDFVQLYQEEKLSKEKELPSDEKFWESYQEFKSNRDAVHEFEVELSLNQIE
                     KVVDDGIYVKVKFGIRQEGLIFVPNMQLDMEEDKVKVFIRETSSYYVYHKDAAEKNCY
                     MKGRTLIRQFSYENQTIPLRRKATVDMIKEKIAEVDALIELEVENQSYVTIKDELVHE
                     LAASELRINELQERMSTLNQVAEYLLASVESKQEMKLNLSKLNITENISANIVEKKLK
                     SLGNQLELERGRYEKMVVRLDKFINRLNTGLSKGDGIDFQK"
     gene            4150..5016
                     /locus_tag="AC0DU4_000827"
     CDS             4150..5016
                     /locus_tag="AC0DU4_000827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000537001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236816.1"
                     /translation="MGTLLATRLKNRRKELKMSQRELAEGICKQGQISRLESGEFTPG
                     ADFLHALAKKLKVSMDYFFDEQVVEEVNELSEFKKLAQTFITNRNYESLKYIYELENV
                     KAHRLSLADKFYMEWIKSLIDFYFYGQKEEAITRLENMLPQLNVSDLNYLQVSNTLFN
                     FYYDIEDLERFNEIRDKLEHQVNQLNLNTIEELELSIKFNYNVCRYLWLQKNIEEAIT
                     KITATIKQCKEYRTTYLLADLYLLMGSVSENFSSKSSVKEYFETAHFLYKLEENMSMA
                     LKVEHYFADITE"
     gene            5607..5858
                     /locus_tag="AC0DU4_000828"
     CDS             5607..5858
                     /locus_tag="AC0DU4_000828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000098314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236817.1"
                     /translation="MSSQMKAFLNELQGNMEVVGEFFDNPEKVIRKFGIVGREKEALL
                     IRDLNDMDDYALSIQNSVASPSGAHSSTCHFVRQDLQSA"
     gene            6087..6389
                     /locus_tag="AC0DU4_000829"
     CDS             6087..6389
                     /locus_tag="AC0DU4_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000792536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236818.1"
                     /translation="MKNKYDVKRIIPDELSESLDIFLKNYSETGLSDYNTYLFYGFIL
                     KSYKLPRENRYSIKLLVKELQNRGLKVTLIINIYYHALNCLALNDGLKIYEEDFLI"
     gene            6386..6853
                     /locus_tag="AC0DU4_000830"
     CDS             6386..6853
                     /locus_tag="AC0DU4_000830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236819.1"
                     /translation="MNYEKYLNYLDYETEIEDAYHNLLLEYKISDNFSDEHWLYNLPS
                     NITQSKGFKIHLSASILNANLVAKKFFDFIFSREKKINFKILVSIKELSLQNTGLNGY
                     SQVGKFITIYPKDNKEFQRLLHKLEILYKGVKGVNIPSDFNLARLYITDMGSS"
     gene            6901..7743
                     /locus_tag="AC0DU4_000831"
     CDS             6901..7743
                     /locus_tag="AC0DU4_000831"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine-protein kinase"
                     /protein_id="HIN4236820.1"
                     /translation="MNVPIRDYYIPRYNTIPDQYIILEVISKNAKGGVYKVFNTQKRV
                     YSLLKEASDLSLVDFTNRDSVNRLINEREILVELEKEEFTPKVFNDFYIKNSYFVEFE
                     FIIADKLSEYNMVSGSYDWFLTLIDYMEIINSKYNLSYRDLSFNNILIDNRNNIYIID
                     FEHALRKETQIEEKKLPLFGTPGFYETNLNLLNNQPEDIMGLVLLLYWSQNLDDFNVF
                     SKMSFLEAMEYAMNFNSRRLDTLDKSDWLYDIYKKAFNYKYDTFSELKKRFYRGIKIK
                     VGVL"
     gene            7758..8657
                     /locus_tag="AC0DU4_000832"
     CDS             7758..8657
                     /locus_tag="AC0DU4_000832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HIN4236821.1"
                     /translation="MNNVSVRYDDVIALKDITLQINKGDFIGLLGSNGAGKSTLINSI
                     VGFQEIYLGEIEYCDKDLIVSSQPFAHLGFTPQTTVIDFYTTVKDNVILGLNLAGKFG
                     KNAEKLCQIALEIVGLADKKNNLVETLSGGQLQRVQIARAIAHNPDFYILDEPTVGLD
                     TESAEKFLMYLKDKSLEGKTIIISSHDINLLEKFCKKILFLQNGSISFFGDMRDFVDN
                     STIKLNFSMQNRISRYQIEFLENFRFKVHIEDNDSFTIEVPIEENILDVINEVGKACE
                     IKNFSTSKLTLQESYLQRIGGEK"
     gene            8654..9454
                     /locus_tag="AC0DU4_000833"
     CDS             8654..9454
                     /locus_tag="AC0DU4_000833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236822.1"
                     /translation="MKADQLRHKSDLGLRGLAIIAKNEIIAFFRSKGLIISQFLQPIL
                     YVVFIIIGLNSSIKNIQFNDIKTSYAEYTIIGVIALLIIGQMTQVIYRVTIDKKYGLL
                     ALKLCSGVRPLYYILGMSIYSILGLIVQEIIIYIITLAFEINIAMDRFFYTVLLSIVV
                     LLFWDSLAILLTMFINDYRRRDIVIRFVLTPLGFTAPVFYLIDSAPSIVRWIGQLNPL
                     TYQLTILRNFYFKNSTTLELVFLLLTSLLVLISVSFIIPKIKLILIER"
     gene            9612..10085
                     /gene="tnpA"
                     /locus_tag="AC0DU4_000834"
     CDS             9612..10085
                     /gene="tnpA"
                     /locus_tag="AC0DU4_000834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001206386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605-like element ISSpn6 family
                     transposase"
                     /protein_id="HIN4236823.1"
                     /translation="MREDNQSLSHTTWNCKYHIVFAPKYRRQIIYGRYKASIGRIIRD
                     LCERKGVIIHEANACSDHIHMLISIPPKLSVSSFMGYLKGKSSLMIFDKHANLKYKYG
                     NRKFWCRGYYVDTVGRNQKVIAEYIQNQLQEDRVADQLTLFESVDPFTGEINKRK"
     gene            10342..10563
                     /locus_tag="AC0DU4_000835"
     CDS             10342..10563
                     /locus_tag="AC0DU4_000835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236824.1"
                     /translation="MYRRLRDLREDHDLTQKQIATILSFTNSAYAKIERSEHALTADV
                     LVKLSDFYDVSTDYLLGLTDFPDKIRFRK"
     gene            10865..11098
                     /locus_tag="AC0DU4_000836"
     CDS             10865..11098
                     /locus_tag="AC0DU4_000836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000693750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HIN4236825.1"
                     /translation="MEIKYVSVENSVAEWADKKSILKRWEGLNLYTLNRWIKEMRENK
                     RFSLYVINPTHKLVFINLEGFECFLRWKQKRTK"
     gene            11174..12682
                     /locus_tag="AC0DU4_000837"
     CDS             11174..12682
                     /locus_tag="AC0DU4_000837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009009 - site-specific recombinase
                     activity [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HIN4236826.1"
                     /translation="MYYVTKTNSKGQPLYQVVEKYKDPLTDKWRTVTVSYTRNTSRAR
                     KQAEREVMDKIEKLTSSLESQYNPEMITTFGELKESWFQTWCVSVKPQTIKREELVIE
                     RLGKIIGDEFLLDRITPLLMKNCLNKYLDKYDASPSTMTHIKSTCNKIFNHGVLYNVI
                     KYSPMTAVKIDVPLEKKRESRKRLDAKFLAIHELQAFFDVLGQCRNASYYDLAIVLLL
                     TGIRIGEAAFLPSDVDFDKGILHIDKALQYHDLKVDEFYFDTTKTVNADREVALPIAA
                     SEAIQRTIKRNQEFEAYMEQNPSPAFKKCDSVFQTEYGSPITSHSFRQVLKRVEEKLL
                     KNCQKDYGFKWVKHVTPHSFKHMHISYLQSNEMHIAVKDIMTRVGHANFETTMGYTHN
                     ISRSQENTVTALNQFVEKHNFHFKELKSYTCKYSRMIEQFIETCDDNNKVELSVDEFK
                     DLLHLGSRYSPKHIVSNLLLKIKKDIVKYHPQFDIKIVKLSGNQIKGFSISW"
     gene            12763..13614
                     /gene="ylqF"
                     /locus_tag="AC0DU4_000838"
     CDS             12763..13614
                     /gene="ylqF"
                     /locus_tag="AC0DU4_000838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HIN4236827.1"
                     /translation="MATIQWFPGHMSKARRQVQENLKFVDFVTILVDARLPLSSQNPM
                     LTKIVGDKPKLLILNKADLADPAMTKEWRQYFESQGIQTLAINSKEQVTVKVVTDAAK
                     KLMADKIARQKERGIQIETLRTMIIGIPNAGKSTLMNRLAGKKIAVVGNKPGVTKGQQ
                     WLKTNKDLEILDTPGILWPKFEDETVALKLALTGAIKDQLLPMDEVTIFGINYFKEHY
                     PEKLAERFKQMKIEEKAPVIIMDMTRALGFRDDYDRFYSLFVKEVRDGKLGNYTLDTL
                     EDLDGND"
     gene            13601..14380
                     /locus_tag="AC0DU4_000839"
     CDS             13601..14380
                     /locus_tag="AC0DU4_000839"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HIN4236828.1"
                     /translation="MATIKEIKEFLVTVKELESPIFLELEKDNRSGVQKEISKRKRAI
                     QAELDENLRLESMLSYEKELYKQGLTLIAGIDEVGRGPLAGPVVAAAVILPKNCKIKG
                     LNDSKKIPKKKHLEIFQVVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSP
                     QPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFPGYDF
                     ATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES"
     gene            14396..15946
                     /locus_tag="AC0DU4_000840"
     CDS             14396..15946
                     /locus_tag="AC0DU4_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA];
                     GO_process: GO:0006821 - chloride transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HIN4236829.1"
                     /translation="MEEQSEIVRSKKEFAFASSTILSQVGRGIIVGLIVGIIVGSFRF
                     LIEKGFHLIQGVYQDQGYLVRNLFVLVLFYILICWLSAKLTRSEKDIKGSGIPQVEAE
                     LKGLMSLNWWGILWKKYVLGILAIASGLMLGREGPSIQLGAVGGKGIAKWLKSSPVEE
                     RSLIASGAAAGLAAAFNAPIAALLFVVEEVYHHFSRFFWVSTLAASIVANFVSLLMFG
                     LTPVLDMPDNIPPMTLDQYWIYLVMGIFLGFSGFLYEKAVLNVGRVYDLIGQKIHLDR
                     AYYPILAFILIIPVGIFLPQIIGGGNQLVLSLTEQNFSFQVLLAYFLIRFIWSMISYG
                     SGLPGGIFLPILALGSLLGALVGVICVNLGLVSQEQFPIFVILGMSGYFGAISKAPLT
                     AMILVTEMVGDIRNLMPLGLVTLVSYIIMDLLKGTPVYEAMLEKMLPEEVSSEGEVTL
                     IEIPVSDKIAGKQVHELNLPHNVLITTQVHNGKSQTVNGSTRMYLGDMIHLVIPKSEI
                     GKVKDLLL"
     gene            16532..17602
                     /gene="xerS"
                     /locus_tag="AC0DU4_000841"
     CDS             16532..17602
                     /gene="xerS"
                     /locus_tag="AC0DU4_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000817875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA];
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine recombinase XerS"
                     /protein_id="HIN4236830.1"
                     /translation="MKREILLERINKLKQLMPWYVLEYYQSKLAVPYSFTTLYEYLKE
                     YDRFFSWVLESGISNADKISDIPLSVLENMSKKDMESFILYLRERPLLNANTTKQGVS
                     QTTINRTLSALSSLYKYLTEEVENDQGEPYFYRNVMKKVSTKKKKETLAARAENIKQK
                     LFLGDETEGFLTYIDQEHPQQLSNRALSSFNKNKERDLAIIALLLASGVRLSEAINLD
                     LRDLNLKMMVIDVTRKGGKRDSVNVAAFAKPYLENYLAIRNQRYKTEKTDTALFLTLY
                     RGVPNRIDASSVEKMVAKYSEDFKVRVTPHKLRHTLATRLYDATKSQVLVSHQLGHAS
                     TQVTDLYTHIVNDEQKNALDSL"
     gene            complement(17675..18664)
                     /locus_tag="AC0DU4_000842"
     CDS             complement(17675..18664)
                     /locus_tag="AC0DU4_000842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000873976.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HIN4236831.1"
                     /translation="MKYIINHSNDTAFNIALEEYAFKHLLDEDQIFLLWINKPSIIVG
                     RHQNTIEEINRDYVRENGIEVVRRISGGGAVYHDLNNLNYTIISKEDENKAFDFKSFS
                     TPVINTLAQLGVKAEFTGRNDLEIDGKKFCGNAQAYINGRIMHHGCLLFDVDLSVLAN
                     ALKVSKDKFESKGVKSVRARVTNIINELPKKITVEKFRDLLLEYMKKEYPEMTEYVFS
                     EEELAEINRIKDTKFGTWDWNYGKSPEFNVRRGTKFTSGKVEVFANVTESKIQDIKIY
                     GDFFGIEDVAAVEDVLRGVKYEREDVLKALKTIDITRYFAGISREEIAEAVVG"
     gene            complement(18728..20431)
                     /gene="lpdA"
                     /locus_tag="AC0DU4_000843"
     CDS             complement(18728..20431)
                     /gene="lpdA"
                     /locus_tag="AC0DU4_000843"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003001382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004148 - dihydrolipoyl dehydrogenase
                     (NADH) activity [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HIN4236832.1"
                     /translation="MALEVIMPKAGVDMTEGQIVQWNKKVGEFVKEGEILLEIMTDKV
                     SMELESEEDGYLIAILKGEGETVPVTEVIGYLGEERENIPTAGAASPEASPVPVASTS
                     NDDGKSDDAFDIVVIGGGPAGYVAAIKAAQLGGKVALVEKSELGGTCLNRGCIPTKTY
                     LHNAEIIENIGHAANRGIVIENPNFTVDMEKLLETKSKVVNTLVGGVAGLLRSYGVTV
                     HKGIGTITKDKNVLVNGSELLETKKIILAGGSKVSKINVPGMESSLVMTSDDILEMNE
                     VPESLVIIGGGVVGIELGQAFMTFGSKVTVIEMMDRIVPAMDAEVSKNLRLILERKGM
                     TILTGTKLQEIIEENGQLRIKVEGKDDIIASKALLSIGRMPDLEGIGEVEFELDRGCI
                     KVNEYMETSVPGIYAPGDINGTKMLAHAAFRMGEVSAENALKGNHAVAKLNLTPAAIY
                     TLPEVAAVGLTEEQAREKYDVAIGKFNFAANGRAIASDAAQGFVKVITDKKYGEILGV
                     HIIGPAAAELINEASSIIEMEITVEEMLKTIHGHPTYSEVMYEAFADVLGMAIHSPKK
                     K"
     gene            complement(20477..21520)
                     /locus_tag="AC0DU4_000844"
     CDS             complement(20477..21520)
                     /locus_tag="AC0DU4_000844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045254 - pyruvate dehydrogenase complex
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006086 - pyruvate decarboxylation to
                     acetyl-CoA [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide acetyltransferase"
                     /protein_id="HIN4236833.1"
                     /translation="MADDKLRATPAARKLADDLGINLYDVSGSGANGRVHKEDVETYK
                     DTNVVRISPLAKRIALEHNIAWQEIQGTGHRGKIMKKDVLALLPENIENDSIKSPAQI
                     EKVEEVPDNVTPYGEIERIPMTPMRKVIAQRMVESYLTAPTFTLNYEVDMTEMLALRK
                     RVLEPIMEATGKKTTVTDLLSLAVVKTLMKHPYINASLTEDGKTIITHNYVNLAMAVG
                     MDNGLMTPVVYNAEKMSLSELVVAFKDVIGRTLDGKLAPSELQNSTFTISNLGMFGVQ
                     SFGPIINQPNSAILGVSSTIEKPVVVNGEIVIRPIMSLGLTIDHRVVDGMAGAKFMKD
                     LKELIETPISMLI"
     gene            complement(21738..22730)
                     /locus_tag="AC0DU4_000845"
     CDS             complement(21738..22730)
                     /locus_tag="AC0DU4_000845"
                     /EC_number="1.2.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000448722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HIN4236834.1"
                     /translation="METKTMSFRDTIILAMSEEMRRDENVFLMGEDVGVFGGDFGTSV
                     GMLEEFGPERVRDCPISEAAISGAAAGAAMTGLRPIVDMTFMDFSVIAMDNIVNQAAK
                     TRYMFGGKGQVPMTVRCAAGNGVGSAAQHSQSLESWFTHIPGLKVVAPGTPADMKGLL
                     KSSIRDKNPVIILEYKSEFNQKGEVPVDPDYTIPLGVGEIKRQGTDVTVVTYGKMLRR
                     VVQAAEELAEEGISVEIVDPRTLVPLDKDIIINSVKKTGKVVLVNDAHKTSGYIGEIS
                     AIISESEAFDYLDAPIRRCAGEDVPMPYAQNLENAMIPTVESIKDAIRKTYNKE"
     gene            complement(22746..23714)
                     /locus_tag="AC0DU4_000846"
     CDS             complement(22746..23714)
                     /locus_tag="AC0DU4_000846"
                     /EC_number="1.2.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016624 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, disulfide as
                     acceptor [Evidence IEA];
                     GO_function: GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HIN4236835.1"
                     /translation="MSTLDKNLLLEMFRKMEEIRRMDLKIAQLVKKGKVPGMTHFSVG
                     EEAANVGAMLALNPDDLITSNHRGHGQAIAKGIDLNGMMAEILGKYTGTCKGKGGSMH
                     IADLDAGNLGANGIVGGGMGIAVGAALSQQMQNTGKIVVCFFGDGATNEGVFHEAVNM
                     ASIWNLPVIFYCINNGYGISADIKKMTNIEHIHQRSAAYGIPGMFIEDGNNVIDVYEG
                     FQKAVDHVRSGNGPVLIESVTYRWLGHSSSDPGKYRTREEVELWKQKDPIENLRNYLI
                     ENNIASAEELEEIQAQVKEAVEASVKFAEESPFPPLESAFEDIYAD"
     gene            complement(23868..25229)
                     /gene="pdrM"
                     /locus_tag="AC0DU4_000847"
     CDS             complement(23868..25229)
                     /gene="pdrM"
                     /locus_tag="AC0DU4_000847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-coupled multidrug efflux MATE transporter
                     PdrM"
                     /protein_id="HIN4236836.1"
                     /translation="MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYDT
                     MDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLGRGKKEEVASDFYQFIYLALGLS
                     VVLLGMVLFLAPTILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLT
                     KLSMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQ
                     EKLKALHLEKRIPLNMDKIKEGVRLGLPIGGTVFAEVAIFSVVGLIMAKFSSLIIASH
                     QSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRWTALIFAAFTLTF
                     LYIFRGNVASLYGNDPKFIDLTVRFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYL
                     GLLGYWGVAIPVATLFDSLTDFGAYSYWIGLIISLIVSGALYRWRLTVIMKRFESLAK
                     SKR"
     gene            complement(25240..25500)
                     /locus_tag="AC0DU4_000848"
     CDS             complement(25240..25500)
                     /locus_tag="AC0DU4_000848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236837.1"
                     /translation="MNYFRKRRERQAKSNSGIYCPAANRSKIQYETKEKADHAVQYDN
                     GGLVRSYYCRTCACWHTTSKSNKPPLSLKNYGLKLFGLDKSE"
     gene            complement(25514..26782)
                     /locus_tag="AC0DU4_000849"
     CDS             complement(25514..26782)
                     /locus_tag="AC0DU4_000849"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004151 - dihydroorotase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HIN4236838.1"
                     /translation="MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETI
                     DATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGFTTVVMMANTSPTISDVE
                     TLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAAGFSDDGIPLESSKIV
                     KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMI
                     AYATKAHVHIQHLSKEESVKVVEFAQGLGAEVTAEVAPQHFSKTEALFLTQGSNAKMN
                     PPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLS
                     LTYLVEAGELSLMELLEKMTYNPAKLYNFEAGYLAENGPADITIFDAKADRLVDSHFA
                     SKAANSPFIGETLKGQVKYTICKGQIVYQA"
     gene            complement(26795..27259)
                     /locus_tag="AC0DU4_000850"
     CDS             complement(26795..27259)
                     /locus_tag="AC0DU4_000850"
                     /EC_number="3.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003012002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016818 - hydrolase activity, acting on
                     acid anhydrides, in phosphorus-containing anhydrides
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HIN4236839.1"
                     /translation="MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGE
                     TPQECAAREILEETGLKAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGT
                     LEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE"
     gene            complement(27269..27922)
                     /locus_tag="AC0DU4_000851"
     CDS             complement(27269..27922)
                     /locus_tag="AC0DU4_000851"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004844 - uracil DNA N-glycosylase
                     activity [Evidence IEA];
                     GO_process: GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HIN4236840.1"
                     /translation="MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQ
                     ALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKK
                     SHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
                     AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR"
     gene            complement(28060..28707)
                     /locus_tag="AC0DU4_000852"
     CDS             complement(28060..28707)
                     /locus_tag="AC0DU4_000852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236841.1"
                     /translation="MTTKKANITIEEYIEMSEVDFNEAVNYEFTSDTCQLANSIYQSL
                     FKFFDKKNFSDDLIFTWKSPSLVKEGDYIGRRDSQVDNLRVIGNIFPNYLTNRKYSLN
                     MNRNGCMGDFPHDFFDIYLDHVAKYAYEQKVNNIKEYYPLKRAILHQENALYFRFFSN
                     FDDFLEKNYLKTIWQVSKETPFSEMDFNMFKNISEKIIFERGSKMLNDLKSNYKK"
     gene            complement(28721..29434)
                     /locus_tag="AC0DU4_000853"
     CDS             complement(28721..29434)
                     /locus_tag="AC0DU4_000853"
                     /EC_number="3.1.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000499426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008253 - 5'-nucleotidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YjjG family noncanonical pyrimidine
                     nucleotidase"
                     /protein_id="HIN4236842.1"
                     /translation="MFYKFLLFDLDHTLLDFDAAEDVALTQLLKEEGVADIQAYKDYY
                     VPMNKALWKDLELKKISKQELVNTRFSRLFSHFGQEKDGSFLAQRYQFYLAQQGQTLS
                     GAHDLLDSLIERDYNLYAATNGITAIQTGRLAQSGLVPYFNQVFISEQLQTQKPDALF
                     YEKIGQQIAGFSKEKTLMIGDSLTADIQGGNNAGIDTIWYNPHHLENHTQAQPTYEVY
                     SYQDLLDCLDKNILEKITF"
     gene            complement(29893..30273)
                     /gene="dhaM"
                     /locus_tag="AC0DU4_000854"
     CDS             complement(29893..30273)
                     /gene="dhaM"
                     /locus_tag="AC0DU4_000854"
                     /EC_number="2.7.1.121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047324 - phosphoenolpyruvate-glycerone
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxyacetone kinase phosphoryl donor subunit
                     DhaM"
                     /protein_id="HIN4236843.1"
                     /translation="MESIGIGLVIVSHSKHIAEGVVELISKVAKDVPITYVGGTEGGG
                     IGTSFDQVDRVVSENPADTLLAFFDLGSAKMNLKMVTDFSDKSIIINRVPIVEGAYNA
                     AALLQAGAELSVIQTQLAELEINK"
     gene            complement(30273..30347)
                     /locus_tag="AC0DU4_000855"
                     /pseudo
     CDS             complement(30273..30347)
                     /locus_tag="AC0DU4_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397816.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxyacetone kinase subunit L"
     gene            complement(30695..>31087)
                     /locus_tag="AC0DU4_000856"
     CDS             complement(30695..>31087)
                     /locus_tag="AC0DU4_000856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine motif-containing protein"
                     /protein_id="HIN4236844.1"
                     /translation="DHVQRNKNGQADTNQTEKPSEEKPQTEKPEEETPREEKPQSEKP
                     ESPKPTEEPEEESPEESEEPQVETEKVEEKLREAEDLLGKIQDPIIKSNAKETLTGLK
                     NNLLFGTQDNNTIMAEAEKLLALLKESK"
BASE COUNT         9949 a         5650 c         5779 g         9709 t
ORIGIN      
        1 tcaataacct aactaagttt aattcagtta gatttacttg attttcttgg atgctataat
       61 caggattttt atgtctagct tttttatagt aaaaatcgaa atctttttct gtaacttcaa
      121 gttgattcac tatgtctttt gatgagaatt tactatttat caagttgtga gtctttttca
      181 attctaattt tgtgtcataa attactatac tatttttaaa tctagttaaa ggatattttt
      241 cgagaccagg tattgaagaa aatactttca gcaattggta ctttaaagta tttttgtata
      301 agcagtgata ataaatagtc tcctgataat ctattttaaa actttctact tcaggggaag
      361 ggactagaca attaccttga tctaaataca tagccataca ctcgtcaatt gtaagatgac
      421 gatatcgaag ttgtactaat tgccaatcaa tattagtctg gtattgattt aaactataag
      481 acatagtttt gaaacgattt gcatcatcgt cgttaagttt aatataaaaa tcgggattag
      541 gattataaat aaaaaatctt ccgtcttcat tttcaatgaa gaaccaattt ttatagtctt
      601 ttaaaacatg aaaatactgc tctttgatat ttaagtcggt atgattaaac ttttgaaaca
      661 actcatttat taactcaaaa ggagcagagg agtctttagg ggtatttata gagccattta
      721 tagcatatat taatcctttt ggtaatgcag tatctttctt aggcttataa tcttttgtta
      781 aaaatacagg aactttatct gtatcatgaa taattaagat gtcaatttct ttgttgtcta
      841 tagtttcagt ttgtatgcta attttaattt gattatttgt tgatataaag agtttatgta
      901 gtaaatctgt tagatcttct tcatttcttc tattatcatc attgtttaca ccgattatat
      961 ctaaagtgat attatcaatt ccaaagatga tataacaatc ttcgtgatgt gatgtattga
     1021 caaaatttaa gatatcacgc accaattcag tttttgaatg atgccatttt tgtttaaaat
     1081 catgaaactc atcttcgggt gtattcaata gtaagtgtat ttgatctaga ctcagcattt
     1141 ttatttctcc aaatattagt ttacagaaat tttatcatag aatcagagaa agtcaatcat
     1201 aactatatta gctgtgatac ctttttcaaa tcttccctgt tatcctaata tcattcatag
     1261 aaaatcaatt tttgattttc tatgggggtt tgggggcgaa gtcaccaagt tatcttatcg
     1321 ttggctgtca aaactagaaa gttttgatag gctggcgata tgatttttga gatattgtgg
     1381 acacaatatc tgagctcgca aagccttaca agaatgaaaa tcagttgttg gaaaagtgta
     1441 ctgacattgt atggtagctc acattgtcag tacaagtatt ttggaaagga agtagcagta
     1501 tgaaacgaga tgtgcgtgat attcggaaac aatttcgttt aacagaagca gaagaaaagc
     1561 aaattctagc tttgatgaga gagcggggag agactaattt ctctgatttt cttcgtaaaa
     1621 gtttactttc ctctgattta caaaaacaga tggagacatg gtttgccctc tggcaatccc
     1681 aaaaactaga acaaatcagt cgtgacgttc atgaagtttt aatcttggca cagtcagaac
     1741 gtcaagtcac ccaagagcat gtatctattc tcttaacgtg cgtgcaggaa ttgattcaag
     1801 aggttgcaaa caccataccc ctcagtaaag aatttcgtga gaagtacatg aggtaagcac
     1861 atggaacatc gttaccgaac caatctcaag aaagtgtttt tgtctgatag tgagttgaac
     1921 caactaaata taaatatcga tcaaagtggt tgtaaatcct tttctgaata tgcgagacga
     1981 actctactcg atcctggtat gaattttatc acgattgaca caaacggtta ccaagattta
     2041 gtgtttgagt taaagaggat tggcaataat atcaaccaga ttgctcgaag tgttaatcaa
     2101 tctcagttaa ttcctggtga agaattgcag gagttgaaaa aaggaattgg tgaattgata
     2161 aaagaagttg ataaggaatt taatctgcaa gcgcagaagc taaaggagtt ccatggtcat
     2221 cactaaacac tttgccattc acggaaagag ttaccgcaga aagcttatca agtacattct
     2281 caatcctgag aaaaccaata atcttgcctt ggtgtcggac tatggcatga agaattttct
     2341 ggactttcct agctatgagg aaatggtgca gatgtatcat gaaaatttca tcagcaacga
     2401 tacgctttac gattttcgcc acgacaggat ggaagaaaat caacgaaaaa tacacgctca
     2461 ccacatcatt cagtctttct cgccagagga tcatctcact cctgaacaaa tcaatcggat
     2521 aggttatgag actgtgaagg aattaactgg tggcaaattt cgttttatcg ttgcgaccca
     2581 tgttgataaa gaccacctgc acaatcacat cattatcaat tcagtagata gcaattctga
     2641 caaaaagctc aagtgggact acaaggtgga gcgaaatctt cgcatgattt ctgaccgttt
     2701 ttctaaaatc gcaggtgcta aaatcattga gaaccgctat tctcaccagc ggtatgaagt
     2761 ctatcgtaag actaatcaca agtatgaact caagcagcga ctctattttt tgatggaaca
     2821 ttctagggac tttgaggatt tcaaaaagaa tgctccgcta ctacatgtgg agatggattt
     2881 ccgtcacaag catgccacct tttttattac ggactcaact atgaaacagg tggtgcgtgg
     2941 caagcaactc aatcgcaagc agccttacac agaagaattt tttaagaact actttgccaa
     3001 aagagaaata gaaagtctca tggaattttt attgctgaaa gttgagaata tggatgattt
     3061 acttcagaaa gcaaaacttt ttggactaac tatcaatcct aaacaaaagc atgtttcttt
     3121 tcaatttgca ggagtggagg taaaggagac agagctagac cagaaaaatc tttatgatgt
     3181 agagtttttc caagattatt ttaaaaatag aaaagattgg caagctccag aaactgagga
     3241 tttcgttcaa ctttatcaag aagaaaagtt atccaaagaa aaagaacttc caagcgatga
     3301 gaagttctgg gagtcctatc aagagttcaa gagtaacaga gatgccgttc atgaatttga
     3361 ggtggagttg tcactcaatc aaattgaaaa agtagtggat gatggaattt acgtcaaggt
     3421 caagtttggt attcgtcagg agggacttat ctttgtgccg aacatgcagc ttgatatgga
     3481 agaggataag gtgaaggttt tcatcaggga aaccagctcc tactatgtct accacaaaga
     3541 cgctgccgag aaaaattgtt atatgaaagg tcgaacctta attagacagt tcagctatga
     3601 aaatcaaacc attccattac gcagaaaagc gacagtcgat atgattaaag agaagattgc
     3661 ggaagtggat gctttgattg aactggaagt agaaaatcaa tcttatgtca cgattaaaga
     3721 tgagttagtg catgaactag cagcgtctga attaagaatc aatgagttgc aagaacgaat
     3781 gtcaaccttg aatcaagtag cagaatatct actggcttca gttgaaagta agcaagaaat
     3841 gaaattaaat ctttcaaaac tgaatataac tgagaatatc agtgctaata ttgttgagaa
     3901 aaaattgaag agcctgggga atcaactgga attggaaagg ggcaggtatg aaaagatggt
     3961 agtcaggcta gataaattta taaatcgctt aaatacagga ctttcaaaag gagatgggat
     4021 agattttcaa aaataggaat ctagccaata attatataca atgtgtatct tttgtaaaat
     4081 atatttgaaa tttagattta atcatgttac aattaacatt gaaatcaaat agaaaaggaa
     4141 gatgcaaacg tgggtacact attagcaaca agattaaaaa atagacgaaa agaattaaaa
     4201 atgtctcagc gagaattagc tgagggtatc tgtaaacagg ggcaaattag tcgattagag
     4261 agtggagagt tcacccctgg agcggatttt ttacatgccc ttgctaagaa attaaaagtt
     4321 agtatggact acttttttga tgagcaggtt gtagaggaag tcaatgagtt atcagagttt
     4381 aagaagttag cacagacatt tatcacaaat cgtaattatg aatctttaaa atatatatat
     4441 gaattggaaa atgtaaaagc ccatcgctta tctctagcag ataaatttta catggaatgg
     4501 ataaagtctc ttatagattt ttatttttat ggacagaaag aagaggcaat tacacgatta
     4561 gagaatatgc tacctcagtt aaatgtatct gatttgaact accttcaagt ttcaaacact
     4621 ctattcaatt tttattatga tattgaagat ttagaacgtt ttaatgagat tagagacaag
     4681 ctagagcatc aagtgaatca gcttaattta aacacaattg aagagttaga actatcaatt
     4741 aagttcaatt ataacgtttg tcgataccta tggttacaga aaaatattga agaagctatt
     4801 acgaaaatca cagctacgat aaagcaatgt aaggagtaca ggacaactta tctattagct
     4861 gatttgtatt tattgatggg aagtgtaagt gaaaattttt cttctaaaag ttcagtaaaa
     4921 gaatattttg agactgctca ttttctctac aaacttgagg aaaacatgtc aatggctttg
     4981 aaagtcgaac attattttgc agatataaca gaataaggaa tacggtgttc tagtgagcat
     5041 cgttttttaa atctaatttg aatacaaaaa agtattaaat aaaaaaaaat aaaaaaagat
     5101 tataaaaata cttgacaagc taattttgaa gtgataaaat aaatgcaaga aaacgaaagg
     5161 agaggtatat gagaagtttg tttaggaaaa ttgttgcttt gttagtcata ggattaatcc
     5221 tattagggac tgctggagga actcaagttc ataagatggc tagagggatt gatcaaggtc
     5281 ctgcgaatgg tatttataga taggagatta tagtcactta aaaatcaaca aattataaaa
     5341 tttttgtttt acttaaatag atattttatg atgggcgaag tttttataac tagttcctat
     5401 aagtacagaa acctatttta atttactaat ttcaaaacaa ttttttgaga tatatgtaat
     5461 taaatctaaa ttaagcttta aaaaattatt tttagcaatt tgattttgaa agtgtcatgc
     5521 agcaatatga aagcgtagaa tagaggtgtt tccaatgtac aagtaagttt tgattccaaa
     5581 taaagtaata gaaaaggagc tatataatga gtagtcaaat gaaagctttc ttgaatgaac
     5641 ttcaaggaaa tatggaagtt gttggagaat tttttgataa tcctgaaaag gtaattagaa
     5701 aatttggaat tgtcggaaga gagaaggaag cattgctaat ccgtgactta aatgatatgg
     5761 atgattatgc tctttcaatt caaaatagcg ttgcatcgcc ttctggggca catagtagca
     5821 cttgccattt tgttagacaa gatttacaat ccgcataatt gttaatatat aaaacataaa
     5881 atttcaattt tcaattaggg ataatagaat tccttactat gatatagaaa gtgaattaat
     5941 taggaaatct tagtcagagg tttctgatta attcattttt tatatattaa gagtgatgtg
     6001 aaatgttcaa attgtgagac tactctcgga ttgttgtata gaaatttaaa attttattgt
     6061 gagcttttta aggaagagtg gccgatatga aaaataaata cgatgttaaa agaattattc
     6121 cggatgaatt atcagaatca ctagatattt ttctaaaaaa ttattctgaa actggattgt
     6181 cagattataa tacttatctc ttttatggtt ttatcttgaa gtcctataaa ttgcctcgag
     6241 aaaatagata tagcataaaa ttattggtga aggaattaca aaatagagga ctgaaagtta
     6301 cattgattat caacatttat tatcacgctt taaattgttt ggctttaaat gatggtctaa
     6361 aaatttatga agaagatttc ttaatatgaa ttacgaaaag tatttaaact atttggacta
     6421 tgaaactgaa atagaagacg cataccataa tttattatta gaatataaaa ttagtgataa
     6481 ttttagtgat gaacattggt tatataattt gccgtctaat atcacccaat ctaagggatt
     6541 taaaatacac ctgagcgctt caatattaaa tgctaatttg gttgctaaaa aattctttga
     6601 ttttatattt tctagagaga agaagataaa tttcaaaatt ttggttagca ttaaagaact
     6661 ttctttgcaa aatacagggc ttaatggtta ttcacaagtc gggaaattca ttacaattta
     6721 tccaaaagat aataaagagt ttcaacgttt gttacacaaa ttagaaatat tgtataaagg
     6781 tgtaaagggt gtaaacatac catcagattt caacttagcg aggttgtata ttacagatat
     6841 ggggagttcg taaaagatag cactttcaag gataaaagag ataagaaaat cccttcaaat
     6901 gtgaatgttc caataaggga ttactatatt ccaagatata acactattcc tgatcaatat
     6961 attattttgg aagtgatttc taaaaatgcc aaaggtggag tttataaagt atttaatact
     7021 caaaagcgag tttattcttt attaaaagaa gctagtgatt tatcgttggt tgattttaca
     7081 aatagagatt ctgtgaatcg tttaataaat gaaagagaaa tattagtaga attggaaaag
     7141 gaggaattta ctccaaaagt ttttaacgat ttttacataa agaattcgta ttttgtggaa
     7201 tttgagttta ttattgcaga taaattaagc gagtataata tggttagtgg ctcgtatgat
     7261 tggtttttaa cattaattga ttatatggag ataataaact ccaaatataa tctttcctat
     7321 agagatttat catttaataa tatacttatt gataatagaa ataatattta tattatagac
     7381 tttgagcatg ccctaaggaa agaaactcaa attgaagaaa aaaagttgcc tctatttgga
     7441 actccagggt tttatgaaac caacttaaat ttattgaata atcaaccaga ggatattatg
     7501 ggattggttt tgttattata ttggagtcag aatttagatg attttaacgt cttttcaaaa
     7561 atgagttttt tagaagcgat ggagtatgca atgaatttta attcgcgtcg cttagacaca
     7621 cttgataaat cagattggct ttatgatatt tataaaaaag cgttcaatta taaatatgat
     7681 actttttctg aattaaaaaa aagattttat agaggtatta aaataaaggt aggggtgtta
     7741 tgaattgttt cttgaaaatg aataatgtaa gtgttcgtta tgatgacgta atagctttaa
     7801 aagatataac tttacaaata aataagggag atttcattgg cttattaggt tcaaatggtg
     7861 caggtaaatc tacgttaatt aattctattg taggttttca agagatttat ttaggagaaa
     7921 tagagtattg tgataaagat ttgatagtta gttctcaacc ttttgctcat ttaggcttta
     7981 ctcctcaaac cacagtaatt gatttttata ctactgtgaa ggacaatgta atattggggc
     8041 tgaaccttgc tggaaagttt gggaaaaatg ctgagaagtt gtgtcaaata gccttagaaa
     8101 ttgttgggtt agctgataaa aaaaataatt tggtagaaac attgtcaggt ggacaactgc
     8161 aacgcgtcca gattgctaga gcaatagctc ataatccaga tttttatatt ttagatgaac
     8221 ctaccgttgg tttagatact gaatctgccg aaaaattttt aatgtattta aaagataaga
     8281 gtttggaagg aaaaactatt atcatatctt cacatgacat aaatctactc gaaaagtttt
     8341 gtaaaaaaat acttttttta caaaatggct ccatatcatt ttttggtgat atgcgtgact
     8401 ttgtagataa ttcaactatc aaattaaatt tttcaatgca gaatagaatt tctagatatc
     8461 aaattgaatt tttagaaaat tttagattta aagttcacat cgaagataat gatagtttta
     8521 caatagaagt ccctatagaa gaaaatatct tagatgttat caatgaggta ggaaaagcat
     8581 gtgaaattaa aaacttttca acaagtaaat taaccttaca agaaagttat ttgcaaagaa
     8641 taggaggaga aaaatgaagg ctgatcaatt aaggcacaaa tcggacttag gtttaagagg
     8701 tctagcgatt attgctaaaa atgagattat tgcttttttt agaagtaaag gtttaattat
     8761 ttctcagttt ctacaaccaa tcttatatgt tgtttttata ataataggat taaattcttc
     8821 gataaagaac attcagttta atgatataaa aacctcttat gcagaatata caatcattgg
     8881 tgttatagct ttattgataa tcgggcagat gactcaagtt atttataggg tgacaataga
     8941 taaaaaatat gggctacttg ctcttaagtt atgcagtgga gttcgtcctt tatattatat
     9001 tttagggatg agtatctatt ctatattagg gttgatagtt caagaaatta ttatatatat
     9061 aattacgtta gcgtttgaga taaatatcgc aatggataga tttttttata cagttttgtt
     9121 atctattgtt gttttattat tttgggactc ccttgcaatt ttacttacaa tgtttatcaa
     9181 tgattacaga agacgtgata ttgtaatacg ttttgtacta acaccgcttg gttttacagc
     9241 tcctgttttc tacttaatag attctgctcc tagtattgtg agatggattg gtcagttaaa
     9301 tcccttaact tatcaattaa ctattttgag aaacttttat tttaaaaatt caacaacttt
     9361 ggaattagtt ttcttattgt taacatcatt acttgtcctt atatctgtat cttttattat
     9421 accaaagata aaattgatac tgatagaaag ataaaagttg ggtcatccaa cttttttgtt
     9481 gtctcccgaa aaccactagc tatgctagtg gttccataga gcttttagcg tggtaacaaa
     9541 aagaacctcc taaaatgata agatagaagt ggtttctccg ccactacaac atatcataca
     9601 ggaggtacct catgagagag gataatcaaa gtttatcaca taccacatgg aattgtaaat
     9661 atcatattgt ttttgcaccc aaatatcgtc gtcaaatcat ttatggcaga tacaaagcta
     9721 gtatcggaag aatcatacgt gacttatgtg agcgtaaggg tgtaataatc catgaagcga
     9781 atgcttgttc agaccatatt cacatgctta tcagtattcc tccgaaactt agtgtttcgt
     9841 cctttatggg ctatttaaag ggcaagagca gtttgatgat ttttgataag catgcgaatt
     9901 taaaatacaa atatggcaat cgcaagtttt ggtgtagagg ctattatgta gatacggtag
     9961 gccgtaatca gaaagtgata gctgaatata ttcagaatca attacaagaa gacagagtag
    10021 cagaccagct cacgttattc gagtcagtag atccgtttac tggcgaaata aataagagga
    10081 agtaactaag gtgctttagc acctgctcgg gaaagtggtg cgcgaggaag ctatttcggt
    10141 gggcctttgg ccctggccgg tagaagcggc ttatagccgc agaacaaacc accagttcac
    10201 actggtggtt ttgatttaaa aaacttgata cataaaaata aaagtctata taaaggatgg
    10261 taaaattcct gttgtccgat ttggacaata tcctaaatag ttacaatata tggtctatac
    10321 tttttcttag gagaaagcta gatgtacaga cgtttgagag atttgaggga ggatcatgat
    10381 ctgacccaaa agcaaatagc tacaatactt tcgtttacaa attcagctta tgccaaaatt
    10441 gaacggagtg agcatgcgtt gacggctgat gtattggtta aactctcaga tttctatgac
    10501 gtcagtacag actatttatt gggattaact gattttcctg ataaaattcg ctttagaaaa
    10561 taatctcctc aatttcatag agtttgaaaa tgagtgagat tttttatttg ccctttgaca
    10621 actgaatagc ctaaaatggt actttcctca tttgtggagc agttttgctt gattcgccaa
    10681 gataggagcg gggacaatca ccaataaaat agagcgatac tctatctgcc atgatgcaaa
    10741 tgatatacaa tgatacttct gaacgttcag gctgccgtcg taaaagagca gtaagtgaga
    10801 ttcttatgat gaccccatca gtcatgccat ggagggagaa gaaattattc gaaaggatga
    10861 taatatggag ataaaatacg tatctgttga aaattcggta gctgagtggg cggataagaa
    10921 aagcatactg aaacgatggg aaggtttgaa tctctacact cttaacagat ggatcaaaga
    10981 aatgagagaa aataagagat tttctttata cgtcatcaat cctacacata agctggtgtt
    11041 tataaatctt gagggattcg aatgcttttt gagatggaaa caaaagcgga caaaataagg
    11101 aagtcatggt ataatataga gtagttattt attctataca acaatgattt atttcttttc
    11161 gaggaattaa attatgtatt atgtaactaa aacaaattca aaaggacaac ccttgtatca
    11221 agtggttgaa aaatataaag atccacttac tgataagtgg agaacagtaa ctgtcagcta
    11281 tactagaaat actagtagag cacgaaagca agctgaaaga gaggtaatgg ataaaataga
    11341 aaaactgacc tcttcccttg aaagtcagta caatcctgaa atgattacaa cttttggaga
    11401 gttaaaagag agttggtttc aaacttggtg cgtatctgtc aagccccaga caataaaaag
    11461 ggaagagttg gtgatagaac ggcttggtaa aattatcggt gatgaatttt tactcgatcg
    11521 aattacacca ctactgatga aaaattgtct taataaatat ctggataaat acgacgcttc
    11581 accttcaaca atgacacata taaaaagtac gtgtaacaag atatttaatc acggtgtgct
    11641 atacaatgtc attaagtact ctccaatgac cgctgttaaa atagatgtgc ctctggagaa
    11701 aaagagagaa tcaagaaaaa ggcttgatgc taaatttctt gcaattcatg aattgcaagc
    11761 cttttttgat gttttagggc agtgtagaaa tgctagctat tatgaccttg ctattgtatt
    11821 attactgaca gggattcgga ttggagaggc tgctttttta ccatcagatg ttgattttga
    11881 taaggggatt ttacatattg ataaggctct ccaatatcat gatttaaaag ttgatgaatt
    11941 ttattttgat acgactaaga ccgtcaatgc tgatagagag gtagccctcc caatagcagc
    12001 gagtgaagca atccagagaa ctataaaaag aaatcaggaa tttgaagcct atatggaaca
    12061 aaatcctagt cctgctttca aaaagtgtga tagtgtattt caaactgagt atggttctcc
    12121 gataacttct cactcatttc gtcaagtttt gaagagggtt gaggagaagt tgttaaaaaa
    12181 ttgtcagaag gattatggtt ttaaatgggt caagcatgtg acccctcatt ctttcaaaca
    12241 tatgcacatt agttatcttc aaagtaatga aatgcacata gctgtaaagg atattatgac
    12301 tagagttggt catgcgaatt ttgaaaccac gatgggctac acccataaca tcagtcgttc
    12361 acaagaaaat actgtaactg ctttaaatca atttgtagaa aagcacaatt ttcactttaa
    12421 agaattgaag agttacacct gtaaatattc gagaatgatt gaacaattca ttgaaacttg
    12481 tgatgataac aataaagtag agttaagtgt tgatgaattt aaagacttat tacaccttgg
    12541 ttcacgttac tcacccaaac atattgtttc aaatttactg ttaaaaatca aaaaagatat
    12601 tgtcaaatat cacccacagt ttgatataaa gattgtgaaa ttaagcggga atcaaatcaa
    12661 aggtttttcc atttcgtggt agttttggtg ttcgcttggt gtttagacga tagtaaaata
    12721 aatgaggggt gctaaaccct tgctacgaaa ggaaaaaact caatggctac tattcaatgg
    12781 tttcctggtc acatgtctaa agctcgtcga caggtgcagg agaatttaaa atttgttgat
    12841 tttgtgacga ttttagtaga tgcacgcttg cctctatcta gtcaaaatcc tatgttgacc
    12901 aagattgttg gtgataaacc aaaactcttg attttaaaca aggccgactt ggctgatcca
    12961 gcaatgacca aggaatggcg tcagtatttt gaatcacaag gaatccagac gctagctatc
    13021 aactccaaag agcaagtgac tgtaaaagtt gtaacagatg cggccaagaa gctcatggct
    13081 gataagattg ctcgccagaa agaacgtggg attcagattg aaaccttgcg tactatgatt
    13141 atcgggattc caaacgctgg taaatcaact ctgatgaatc gtttggctgg taaaaagatt
    13201 gctgttgttg gaaacaagcc aggggtcaca aaaggtcaac aatggcttaa aaccaataaa
    13261 gacctggaaa tcttggatac accggggatt ctctggccta agtttgagga tgaaactgtt
    13321 gcacttaagt tggcattgac tggagctatc aaagaccagt tgcttcctat ggatgaggtt
    13381 accatttttg gtatcaatta tttcaaagaa cattatccag aaaagctggc tgaacgcttc
    13441 aaacaaatga aaattgaaga aaaagcgcct gtgattatta tggatatgac ccgcgccctc
    13501 ggtttccgtg atgactatga ccgtttttac agtctcttcg tgaaggaagt ccgtgatggc
    13561 aaactcggta actatacctt agatacattg gaagacctcg atggcaacga ttaaagaaat
    13621 caaagaattc cttgtgacag tcaaggagtt agaaagccct atttttttag agcttgaaaa
    13681 ggataatcgc tcaggagttc aaaaggaaat cagcaagcgt aaaagagcca tccaagctga
    13741 attagatgaa aatttgcgct tggaatccat gctttcttat gaaaaagaac tttataagca
    13801 aggattgacc ttaattgcag gtattgatga ggttggtcgt ggtcctcttg ctggtcctgt
    13861 agtcgctgcg gccgttattt tacctaaaaa ttgtaagatt aaaggtctca acgacagcaa
    13921 gaaaattcct aaaaagaaac atctggagat tttccaagtc gttcaagacc aagccttgtc
    13981 gattggaatt ggtatcatag ataatcaggt catcgaccaa gtcaatatct atgaagcaac
    14041 caaactagcc atgcaagaag caatctccca gctcagccct caaccagagc accttttgat
    14101 tgatgccatg aaactggact tgcccatttc acaaacctcc attatcaaag gagatgccaa
    14161 ctccctctct atcgcagcag catctatagt agccaaggta acacgtgatg aattgatgaa
    14221 ggaatacgat cagcagttcc ctggctatga tttcgctact aatgcaggat atggcacagc
    14281 taaacatctg gaaggcctca caaaactagg agttacccca attcaccgaa ccagctttga
    14341 acccgttaaa tcactggttt taggtaaaaa agaaagttaa ttgaaaggaa ataccatgga
    14401 ggaacaatcg gaaatagtcc gttctaagaa agaattcgcc tttgcatcca gcactatact
    14461 atcccaagtt ggtcgaggaa tcattgtcgg cctcatcgtt ggaattatcg tcggatcctt
    14521 tcgtttctta attgaaaagg gcttccacct gatacaagga gtttatcaag atcaagggta
    14581 cttagtgcgc aatctttttg tactggtttt gttttatata ctcatctgtt ggctcagtgc
    14641 caaactaaca cggtcagaaa aagatattaa aggctcagga attcctcaag tcgaagccga
    14701 actgaaaggc ctcatgtccc tcaactggtg gggcattctt tggaaaaaat atgtgctagg
    14761 tattcttgct attgccagtg gactcatgct gggtcgagag ggacccagca ttcaacttgg
    14821 agcagttggt ggtaaaggaa ttgccaagtg gctcaaatcc agtccagtag aggaacgttc
    14881 cttgattgct agtggagctg cagcaggttt agccgcagcc tttaatgctc ctattgcagc
    14941 acttctcttt gttgtagaag aagtctatca ccatttttcg cgctttttct gggtctcaac
    15001 tctagcagcc agcatcgtag caaactttgt gtctctactc atgttcggtt tgacaccagt
    15061 attggatatg ccagataaca ttcctcccat gaccctagac cagtattgga tatatctcgt
    15121 catgggaatt ttccttggat tttcaggttt tctctatgag aaagctgtat taaacgttgg
    15181 aagagtttat gacttgattg gtcaaaaaat ccatttggat agggcttatt atcccatctt
    15241 ggcttttatc cttatcatac cagtcggaat cttcttacct caaatcattg gtggcggaaa
    15301 tcagcttgtc ctttctttaa ctgaacaaaa ttttagtttc caagttttat tagcttactt
    15361 tttgatccgc tttatttgga gtatgattag ctatggaagt ggactgccag gaggaatttt
    15421 cctccccatt ttagctcttg gttctttgct tggtgcctta gttggtgtta tctgtgtcaa
    15481 tcttggactt gtcagtcaag agcaattccc tatatttgtc attctaggaa tgagtggcta
    15541 ttttggagcc atatcaaaag ctcccttaac cgctatgatc ctcgtaactg agatggtagg
    15601 agatattcgc aacctcatgc cacttggtct tgtcactctt gtttcttata ttatcatgga
    15661 tttgctcaaa ggtacgccag tctatgaagc catgctggaa aaaatgcttc cagaagaagt
    15721 atctagcgaa ggagaagtta cacttatcga aataccagtt tctgataaaa ttgctgggaa
    15781 acaagttcat gaactcaact taccacacaa cgtcctcatc acaactcaag tccataatgg
    15841 caagagccaa acagttaacg gctcaaccag aatgtatctg ggtgatatga ttcacctggt
    15901 tattccaaaa agtgaaattg gaaaagtcaa agatttgttg ttgtagtatg agcatttaca
    15961 taatttatgt tatgtaaatg ctcagcttga tttatttaga aaaccgattc tcagaaatga
    16021 gatcggttat tttttactga tgaggaattt tacatataaa taattgaact ttattaaaaa
    16081 taagactata attaattaag ttagaaatga taaagcataa agctagaaag gagtttactg
    16141 tatcaaatct gtacagtaag attaaaatca tgaaaaagaa aacaatagta attatagtga
    16201 aatgaaatag aaataggata aaacaaacag gacaatcaaa tcaatttcta gcaatgtttt
    16261 agaagtccag atgtactatt ctagtttcaa tctattatac aatgtgtttt gtatctcata
    16321 gctccttata tagctcttca gttatgtagt attaacagaa gtttagtggg tgagattttc
    16381 attattttcc ttattctgtt ttgtttgtag gtctaagtct ttttatcact ttgaaaaact
    16441 cctataacat ctttctgaaa aactataatt ttcttgaaaa atatacaagt ctatgctata
    16501 ctactagtat acttacttat ggagaaaata catgaaacgt gagattttac tggaacgaat
    16561 caacaaacta aaacaactca tgccctggta tgttctggaa tactaccaat ctaaactggc
    16621 tgtgccctac agttttacaa ccctgtacga ataccttaag gaatatgacc gatttttcag
    16681 ctgggttttg gagtctggta tttcaaacgc tgataaaata tccgatattc ctttatcagt
    16741 tttggaaaat atgtctaaga aagacatgga atcctttatc ctttatctac gtgaacgtcc
    16801 cttgctgaat gctaatacaa caaaacaagg tgtttcacag acaactatca atcgaacctt
    16861 atcagcactt tctagtcttt acaagtatct aaccgaggag gttgaaaacg atcaggggga
    16921 accttatttc tatcgtaatg taatgaaaaa agtttcaacc aagaaaaaga aagaaaccct
    16981 tgctgccaga gctgaaaata tcaagcaaaa actctttcta ggtgatgaaa cagaaggttt
    17041 tctaacttat atcgatcaag agcacccaca acagctttca aatcgagctc tctcatcatt
    17101 caacaaaaat aaagaacgag atttagccat tattgccctt ctcttggcat ctggtgttcg
    17161 cttatctgaa gctattaatc tagatctaag agatctcaat ctaaaaatga tggttattga
    17221 tgttactcga aaaggtggca aacgtgactc agtcaatgtc gctgcttttg ctaaacctta
    17281 tttagagaat tatctggcca ttcggaatca acgctataaa acggaaaaaa cagatacagc
    17341 ccttttttta actctctaca gaggtgttcc taatcgtatc gatgcttcta gcgttgagaa
    17401 aatggttgct aaatactcag aggattttaa agtacgtgta acaccccata aactgcgcca
    17461 tacactagca actaggctct atgatgctac taaatcacaa gttttagtca gtcaccaact
    17521 aggacatgcc agcacacaag tcactgacct ctatacccat attgttaatg atgaacaaaa
    17581 gaatgctctg gatagtttat gattttacgt attttaaatt atgtaaataa atatcaaaaa
    17641 aagaagttgg ttagttggcc aacttctttt tgatttatcc aactaccgct tcagcgattt
    17701 cttcacggct aataccagcg aagtagcgtg tgatatcaat ggtttttagc gccttaagaa
    17761 catcttcgcg ttcgtatttc accccacgaa ggacatcttc tactgcagca acgtcttcaa
    17821 taccaaagaa gtcaccataa atcttgatgt cttggatttt tgattcagta acgttagcaa
    17881 agacttcaac cttaccacta gtgaatttgg ttccacgacg gacgttaaat tcaggtgatt
    17941 taccatagtt ccagtcccaa gttccaaact tagtatcctt gatgcgattg atttcggcca
    18001 attcttcttc tgaaaagacg tattcagtca tctctgggta ctcttttttc atgtattcca
    18061 agagtaaatc acggaatttt tcgactgtga ttttttttgg taattcattg ataatattgg
    18121 ttacacgggc acggacggat ttcacacctt ttgattcaaa tttatctttt gaaaccttaa
    18181 gggcatttgc gaggactgac aaatcaacgt caaagagcaa gcaaccgtgg tgcatgatac
    18241 ggccgttgat ataggcttgg gcattgccac agaacttctt accatcaatc tcaaggtcat
    18301 tacgacctgt gaactcagct ttaaccccaa gttgagccag ggtattgata accggagttg
    18361 agaagctctt gaagtcaaat gccttatttt catcttcttt ggagatgatc gtgtagttga
    18421 ggttatttaa atcgtggtaa acagctccac caccactaat acggcgaact acctcaatac
    18481 cattttcgcg aacataatca cggttgattt cttcgatagt gttctggtga cgaccaacaa
    18541 tgatagatgg cttgttaatc caaagtagga agatttgatc ctcatccaaa aggtgtttaa
    18601 aggcgtattc ttccaaggca atattaaaag cagtgtcatt tgaatgattg ataatgtatt
    18661 tcatgatatc cctttacttt atatgataga aactggaaat aaccttccag tctaatctat
    18721 ctttgtttta ttttttctta ggtgaatgga tggccattcc tagaacatct gcaaacgctt
    18781 cgtacatcac ttcagagtaa gttgggtgcc cgtggatggt cttcagcatt tcctcaacag
    18841 tgatttccat ttcgatgatg cttgatgctt cgtttattaa ttctgcggct gcaggaccaa
    18901 taatgtgtac accaaggatt tctccgtatt tcttatcagt gataactttt acgaaacctt
    18961 gagcagcgtc agatgcaata gcacgaccgt tagcagcaaa gttaaactta ccgatggcaa
    19021 catcgtattt ctcacgggct tgttcttctg tcaaacctac tgctgctact tcagggagag
    19081 tgtagatggc tgcaggagtc aaattcaatt tggcaactgc atgatttcct ttaagggcat
    19141 tttcagcgga aacttcaccc atgcggaaag ctgcgtgagc caacatctta gtaccgttga
    19201 tgtcacctgg tgcataaatg cctggaactg aagtttccat gtattcgttg accttgatac
    19261 aaccacgatc caattcaaac tcaacctctc caataccttc aaggtctggc atacgaccaa
    19321 ttgaaagaag agctttgctt gcgatgatat cgtcttttcc ttcaaccttg atacgaagtt
    19381 gaccattttc ctcaatgatt tcttgcagtt tagtaccagt caagatggtc attcctttac
    19441 gctcaaggat caagcgaagg ttcttagaaa cttccgcatc catagctgga actatacggt
    19501 ccatcatttc gataacagtc acttttgaac caaatgtcat gaaggcctga ccgagttcga
    19561 taccgacaac tccaccaccg atgataacaa ggctttctgg cacttcgttc atttcaagaa
    19621 tgtcatcact agtcatgaca agtgaagatt ccataccagg gacgttgatc ttgctgactt
    19681 ttgaaccacc agcaagaatg attttcttgg tttcaagcaa ttcagaacca tttaccaaga
    19741 cgttcttgtc tttagtgatt gtaccaattc ctttatgaac agtaactccg tagctacgaa
    19801 gaagtcctgc aacaccacca acaagagtat taacaacttt agatttagtt tctaaaagtt
    19861 tttccatatc aacagtgaag ttaggatttt caatcacgat accacgattt gcagcatgac
    19921 cgatattttc aataatttca gcgttatgaa ggtaggtctt ggttggaata catccacggt
    19981 ttaagcaggt tccaccaagt tcagatttct caacaagggc aaccttaccg ccgagttggg
    20041 cagctttaat ggctgcaaca taaccagcag gacctccacc aatcacaacg atatcaaaag
    20101 catcatcgct cttaccatca tcgtttgagg tacttgctac aggtacaggg ctagcttctg
    20161 gcgatgctgc tccagctgtt gggatgtttt ccctttcttc accaaggtaa ccgataactt
    20221 ccgttacagg gacagtttca ccctctcctt tgagaatggc aatcaagtac ccatcttctt
    20281 cggattccaa ttccatgctg actttatcag tcatgatttc caaaaggatt tctccttctt
    20341 ttacaaattc tccgactttt ttattccatt ggacgatttg tccttctgtc atatccacgc
    20401 cggcttttgg cataattact tctaaggcca tgtcttcctt cctttatcta tatcttaaaa
    20461 atgaatactc ttgctcttaa atcaacattg agattggggt ttcaatcaac tctttcaagt
    20521 ccttcataaa cttagcacca gccataccat ctacgacacg gtggtcaata gttaatccta
    20581 aactcatgat tgggcgaatc acaatttcac cattgacgac aactggcttc tcgattgtcg
    20641 aactgacacc aaggatagct gagttgggtt ggttaataat cggaccaaag gactgaacac
    20701 caaacattcc caaattactg attgtgaatg ttgaattttg taactcactt ggagccaatt
    20761 taccatccaa ggtacggcca ataacatcct taaaggctac aaccagttct gaaagactca
    20821 tcttctcagc attgtaaaca acaggtgtca tcaatccatt atccatccca actgccatgg
    20881 caagattgac atagttgtga gtgataatag tcttgccatc ttctgtcaat gaagcgttga
    20941 tgtatggatg tttcataaga gtcttaacaa ctgcaagtga aagaaggtct gttacagtag
    21001 tcttcttccc agttgcttcc atgattggct caagaaccct cttacgaaga gccaacattt
    21061 cagtcatatc aacttcatag ttgagggtga aggttggcgc agtcaagtaa gattcaacca
    21121 tgcgttgggc aataacctta cgcattggtg tcattggaat acgctcgatt tcaccatatg
    21181 gtgttacgtt atcagggact tcttccactt tttcaatctg agcaggagat ttgatgctat
    21241 cgttttcgat attttcagga agcagggcca aaacatcctt cttcatgatt ttaccacgat
    21301 gaccggttcc ttggatttcc tgccaagcaa tgttatgttc gagggcaatt cgttttgcaa
    21361 gtggcgaaat gcgaaccacg tttgtgtctt tataagtttc cacgtcttct ttgtggacac
    21421 gaccgtttgc acctgagcca gaaacgtcgt agaggtttat ccctaaatca tccgctaact
    21481 ttctagctgc aggagtcgct cttagcttgt catcagccat gacctctcca attctattta
    21541 tgatacaaag ggcgtcaaaa gcgactgaaa aataggaaat cgacgatggc ttcgatgaag
    21601 ccaaggagat ttatcttttt tccgagcttt tagcccgtgc tctaatctaa gatattaatg
    21661 acgaagagct ctgcacctaa aagatacaaa gtttctcgtc agctttattt tatttacata
    21721 acttatctta tgtaactcta ttctttgtta taagtttttc ggattgcatc tttgatactt
    21781 tcaactgttg gaatcattgc attttctagg ttttgtgcat aaggcatcgg cacatcttct
    21841 cctgcacaac ggcgaattgg tgcatctaga tagtcaaatg cttctgattc tgaaataata
    21901 gctgaaattt caccgatata gccacttgtt ttgtgggcat cgttgaccag aacaacctta
    21961 ccagtcttct tcactgagtt tatgatgata tccttatcaa gcggaacaag ggtacgtggg
    22021 tcaacaattt caactgaaat tccttcttct gctaattctt cagcagcttg aaccacacgg
    22081 cgaagcattt ttccataagt aacaactgtt acatccgttc cttggcgttt gatttcacca
    22141 accccaagtg gaattgtgta gtctggatca actggcactt cccctttttg gttaaattct
    22201 gacttgtact caagtataat aactgggttt ttatcacgga tagaagactt aagcaggcct
    22261 ttcatgtccg caggtgttcc aggtgccaca accttaagtc ctggaatgtg agtaaaccaa
    22321 gactctagag attgtgagtg ctgggcggca gagccaactc cgttaccagc tgcacaacga
    22381 acagtcattg gaacctgacc tttaccacca aacatgtaac gtgttttagc agcttggttg
    22441 acgatattgt ccatggcaat aacagagaag tccatgaagg tcatatcgac gattggacga
    22501 agtcctgtca tggcagctcc tgctgctgct ccagagatgg cagcttcaga aatcggacag
    22561 tcacggacgc gttctggacc aaattcttca agcattccaa cagaagtacc gaagtctcct
    22621 ccgaagacac cgacgtcttc tcccatcaag aacacatttt catcgcgacg catttcctca
    22681 gacatagcaa ggataatggt gtcacggaag gacattgttt ttgtttccat tttatctctt
    22741 tctccttagt ctgcgtaaat atcttcaaag gctgattcaa gcggtgggaa tgggctttcc
    22801 tctgcaaatt taacagaagc ttctactgct tcctttactt gcgcttggat ttcttccaat
    22861 tcttcggcac ttgcaatgtt attttcaata aggtaattgc ggaggttttc gattggatct
    22921 ttttgtttcc acaattccac ttcttcacgc gtacgatatt taccagggtc agatgatgag
    22981 tgaccgagcc agcgataagt tacactttca atcaagactg gaccattgcc actgcgaaca
    23041 tggtccacag ctttctgaaa tccttcatag acatcgatga cattgttacc atcttcgatg
    23101 aacattccag gaattccata agcggcgcta cgttgatgga tatgttctat attggtcatt
    23161 ttcttgatat ccgcagagat accgtaaccg ttgttaatgc aatagaaaat gactggcagg
    23221 ttccagatag aagccatgtt cactgcttcg tggaaaacac cttcattggt cgcaccatct
    23281 ccaaagaagc agacaacgat tttaccggta ttttgcattt gctgactgag ggctgcaccg
    23341 acagcgatcc ccataccacc acctacaata ccattggcac caaggttccc agcatcaagg
    23401 tcagcgatat gcatagatcc acctttccct ttacaggttc cagtgtattt accaaggatt
    23461 tcagccatca ttccgttgag gtcaatccct ttagcaatag cttgcccgtg tccacggtgg
    23521 tttgaggtaa tcagatcatc tggattgaga gctaacatag cccccacgtt agctgcctct
    23581 tcaccaacag aaaagtgcgt cattcctggc actttccctt tctttactaa ttgtgcaatt
    23641 tttaagtcca tgcgacggat ttcttccatc ttacggaaca tttctagcaa aagattttta
    23701 tctaaagttg acatcttctt gcctttctaa ctttcttctt accttactat tttaccgttt
    23761 ttggcaaata ctgtcaaagt ttttctaaaa gaaatttcac aaaataaaaa agaaaacccc
    23821 gtgaaaacaa gggattttct tatcaagaat attttttcac aaacttttta gcgtttggat
    23881 tttgctaaag attcaaatct cttcataatc acagttaaac gccaacggta gagcgcccca
    23941 ctcacaatca aactaataat caagccgatc cagtaagaat aagctccaaa atctgttaga
    24001 gaatcaaata gcgtagccac agggattgct acgccccaat aaccaagcaa accaaggtaa
    24061 aaaggaataa ctgtatcctt atacccccgc aaaattccct gaagcggcgc cgcaaaggta
    24121 tctgctaact ggaagaaaag actataagtt aaaaaacgca ctgtcaaatc gataaatttt
    24181 gggtcgttac cataaagact ggccacattt cccctaaaaa tgtaaaggaa ggttaaggtg
    24241 aaggccgcaa aaatgagggc agtccatctt cctagaccaa tataggtttt cgcatcatca
    24301 aatcgcttgg ctcccacttc ataggaaacg acaatagcca tagccgatga gatactcata
    24361 ggaaaggcgt acataagact tgaaaagttc atagctgact ggtgactagc tataatcaag
    24421 gacgaaaact tagccataat caagccaacc actgaaaaga tagccacttc cgcgaagaca
    24481 gttcccccaa taggcagacc taaacgaact ccttccttaa ttttatccat attaagtgga
    24541 attcgtttct caaggtgtaa ggctttgagc ttctcctgtt taaataaaac cagaacagaa
    24601 atcccaagca agacccagta ggccaaggat gttcctaaac cagcaccagc ccctcccagt
    24661 tctggaacac caaaggcacc gtaaatcaag agatagttaa atccgctatt gagagggagt
    24721 aacaaaagca tgaggtacat ggacagtttg gtcaagccca gcgaatccag caaggaacga
    24781 atgacgctaa agagcaacaa ggggataatc ccgatagata aaaaccaaag atagcgaacc
    24841 gctactgccg ctactgctgc ttctaaccca atatgattca agattgttgg tgccaagaaa
    24901 agtaccatcc ccagcaatac cacagatagg cccaaggcca aataaataaa ttggtaaaaa
    24961 tcagacgcaa cttcttcctt ttttcctcga ccaagatggt gaccaatgat aggcaccaag
    25021 gctgacacaa tccctgttag aaatgtaaag aaaggattcc agatactggt tgccatagat
    25081 acaccagcca agtccatagt gtcgtattga cctgtcattg cagtatcaac aaaagaggca
    25141 gaataattgg caaattggta aatcaggatt gggaagaaaa tttttaaaaa taatactaac
    25201 ttctctcgta aacactttgt cttatacata cttctctttc tattctgatt tatctaaacc
    25261 aaagagtttc agaccatagt ttttcaaact tagcggaggt ttattagatt ttgaagtagt
    25321 atgccaacac gcacatgtac gacaataata gcttctaact aaacctccgt tatcatattg
    25381 aaccgcatgg tcagcttttt ctttagtttc atattgaatt ttggaacgat tagctgcggg
    25441 acagtaaatt ccactattag atttcgcttg tctctcccta cgttttcgaa aataattcat
    25501 attctaactc ctatcaagct tgatagacga tttgtccctt acagatggta tatttaacct
    25561 gcccttttaa ggtttcaccg atgaatggtg aattagctgc tttggaagca aaatgggagt
    25621 ccacaaggcg gtcagccttg gcatcaaaaa tagtgatatc tgctggacca ttctcagcca
    25681 agtaacctgc ttcaaagttg taaagcttgg ctgggttgta tgtcattttt tcaagtaatt
    25741 ccatcaagct caactcacca gcttctacta aataggtcaa gctgagagac agggatgttt
    25801 ctaagccagt cataccagat ggcgctttgg taatatcctc aacatttttt tcatctacat
    25861 gatgaggcgc gtggtcagtc gcaataactg tgatgacacc tgatttgaga ccttcgataa
    25921 cggcacgacg gtctgattcc aaacgaagcg gtggattcat cttagcattg ctaccttgtg
    25981 ttaaaaaaag tgcttctgtc ttagagaaat gctgtggcgc tacttctgct gtgacttctg
    26041 cacctaaccc ctgagcaaac tccactactt taacactttc ttccttagac aaatgctgga
    26101 tgtgaacatg ggctttagtt gcataggcaa tcatgacatc acgcgccatc atagcgtact
    26161 cagccacccc agtagcaccg cagatatgga aatgttctct agcaatattt tcattaaagc
    26221 caagaacacc gttcaaacct ggatcttcct catgaaggct gataaaggta ttgagttttt
    26281 tggcttcctc catggcttcc ttgacaatct tactgctctc aagcggaata ccgtcatcag
    26341 agaaaccagc cgcaccagct tctaagagcg ccttaaagtc agtcaagttt ttaccattaa
    26401 agtttttagt aatggtcgca actgtcttga cattaatctt ctctttggca gctgactgga
    26461 gaactgcttg caaagtctcc acgtctgaaa tggttggact ggtattagcc atcatgacga
    26521 cagtagtaaa accacctgca gcggctgcca gggcaccagt atgaatgtct tctttatgtg
    26581 tttgaccagg ttcacggaaa tgcacatgaa tatcgaccaa accaggagca accacaagac
    26641 cagtagcatc aatcgtttct gctccttctt ccgtgatctc aggcgcaatt ttgataattt
    26701 tcccatcttg aactaagaca tcacaaactt gatccaaacc agacttggga tccattacac
    26761 gaccattttt gattagtagc atctgctttc tcctttattc atagaaatca acttgggtat
    26821 ccaacaattt atccccatca taaacaaact tggctgaaaa gaagggttta tcctctaaaa
    26881 gccactcaac aaaggtgtgg tcaccttccc aagtcggctt gctcaaaacc tcatcatagg
    26941 gaacccattc tagcgtcccc tcattgcagt caatcaagtc gccctcaaac tccgtcacct
    27001 taaaaacata ggtgtaccag tctaaatctg gtgtaaattc aggaaaagtg atgacacctt
    27061 ttagaactgg cttggctttg agccctgttt cttcaaggat ttcacgcgcc gcgcattcct
    27121 ggggcgtctc tcctctctct agcttaccac ccacaccaat ccatttccct tcatggacat
    27181 cattgggttt cttattacga tggagcatga gcagttcttt cccattatca atgtagcaaa
    27241 tcgtcgctaa ctgaggcata ttttctcctt atctaagcca atcgattggc tcttgtcctg
    27301 tctcttttaa gaatgcattg gccttggaaa agggcttgga accccaaaat cctctataaa
    27361 ccgacaaagg acttggatgg gctgattcga taatcaagtg atgaggattg gtaactaatg
    27421 ccttcttctt acgtgcataa gctccccaga gtacaaaaac gactggtcta tctagatgat
    27481 tgaccacctg aatcacagca tcagtaaaag gctcccagat ttgaccagca tgaccattgg
    27541 cctgtccagc aggaacagtc aaacaagcat taagaagcaa gactccttgc tcagcccaag
    27601 ctgtcaaatc atgagatttc ttaactccga tatcatctga caattctttc aagatatttt
    27661 gcaaggatgg tggagctggg atagagtcag gtacagaaaa actcaagccc tgcgcttgac
    27721 ctggtccgtg ataggggtct tgccctagaa ttaccacctt aacttcttca agcagtgttg
    27781 tcaagagagc ctgaaaaacc ttttccttgg gtggataaat aatcccctga gaatagacct
    27841 gctccataaa ctgattgatt ttcccgaaat aaccctcagg taattgcgcc ttaatcaaag
    27901 catgccaaga cgagtgttcc atagccgact ccttcatttt tactgcctct attatagcaa
    27961 aaagtggcta tggaaaccac tttttacagt ttatctaaag atttaataaa tcgactatat
    28021 atacgatttg aatacgtgaa tacagtttat aaagactggc tattttttat aattactttt
    28081 taaatcatta agcattttac tacctctttc gaagattatc ttttctgaaa tatttttaaa
    28141 catattaaaa tccatttcag aaaaaggagt ttctttagaa acttgccata tagtctttaa
    28201 ataatttttt tctaaaaagt cgtcaaaatt agaaaaaaat cgaaaataca atgcattctc
    28261 ttggtgtaaa atcgctcttt ttaaaggata atactcttta atattattaa ctttttgttc
    28321 gtaggcatat tttgctacat gatctaggta tatatcaaaa aagtcatgag gaaaatctcc
    28381 catacagcca ttacgattca tattgaggct atattttcga ttagtaagat aattcggaaa
    28441 tatatttcct attactctaa gattatctac ttgtgaatcc cttctcccaa tataatcccc
    28501 ttctttgact aatgatggag atttccaagt aaaaattaaa tcgtcagaga aatttttctt
    28561 atcaaaaaac ttaaaaagag attgataaat actatttgct aattgacaag tgtcagatgt
    28621 aaattcataa ttaacagctt cattaaaatc aacttcagac atttcaatgt actcttcaat
    28681 agtaatatta gctttttttg tagtcattag ctaatctcct ttaaaatgtg atcttttcaa
    28741 gaatattttt atctaaacaa tccagcaagt cttggtaaga atagacttcg taagtcggct
    28801 gggcttgtgt gtgattttcg aggtgatgag gattatacca gatagtgtca atccccgcat
    28861 tattgccacc ttgaatgtcg gcggttagag aatctccaat catcagcgtc ttttctttac
    28921 taaatccagc aatttgctgg ccaatctttt cataaaagag agcatccggc ttttgagttt
    28981 gcaactgttc tgagataaag acttgattga aataaggtac tagaccagat tgagccaaac
    29041 gtcctgtctg aatggcagta atgccatttg tcgcagcata caagttataa tcacgctcaa
    29101 tgaggctgtc caagagatca tgagcgcccg atagtgtttg tccctgctga gcgagataaa
    29161 attggtaacg ctgggcaaga aaactaccgt ctttttcctg tccaaaatga gaaaataaac
    29221 gagaaaagcg cgtgttaacc agctcttgtt tactgatttt cttcagctcc aagtctttcc
    29281 agagagcctt gttcatagga acgtaataat ctttataagc ctgaatatcc gcaactcctt
    29341 cttcttttag aagttgggtc aaagccacat cctcagcagc atcaaaatca agaagagtgt
    29401 ggtcgaggtc gaagagtaga aatttgtaga acaatttgag gttttccttt ctgaaaattc
    29461 attaagaaca ttatatcata aagcacctca tacaattaac taatttaatc acttaaaaaa
    29521 aattcgaaca ctttctatac aactgacagc tcaaatcttt cagaatagaa caatactaac
    29581 tatcgagcac cctgtcttca taaatatatg tgtaattcta gacctagaat tcctataaac
    29641 taaatgcttt catactcttc caagtaattg attgccttaa attttaattt ttgaaggatt
    29701 ctaaagctag aatagtccca tcacaatcag ttttgattga ttcacaattt agaaacacta
    29761 tagtttcact cctgttaaaa taaaaaggaa ctgcataaag caatcccttt ctgattttga
    29821 aatcatttac ttaacatttt atagttgaga taatcaatag cttacctata aaaagagtta
    29881 tagtaaaatt ccttatttat tgatttcaag ctccgctaac tgtgtttgaa taactgacag
    29941 ttctgcacca gcctgaagaa gagcagctgc attataggca ccttctacaa ttggaaccct
    30001 gttgatgatg atacttttat cactgaaatc agtcaccatt tttaagttca ttttagcaga
    30061 acctaggtca aaaaaggcaa gtaaagtatc tgctggattt tcggaaacaa ccctatctac
    30121 ttgatcaaaa ctcgttccaa ttcctccgcc ctcggttcct cctacataag taatcggaac
    30181 atctttagct actttactaa tcagttcaac aacaccttct gcaatgtgtt tggaatgtga
    30241 aacgataaca agaccaatac caatactttc catcaaacca ccccagtttc taaaatagca
    30301 gtaaagagta atcctgatga gaatgatcca ggatcaatat gtccaagaaa ccacatgctc
    30361 ctaagacaag agctaacaga ctggccatca ataatagtat tgttcttttt ttcatcatta
    30421 ctccttaact agtgtttaac tgatcaatta gccagtaaat agtttatctt tatttacact
    30481 atctgttaag atatagtaaa atgaaataag aacaggacag tcaaatcgat ttctaacaat
    30541 gttttagaag tagaggtata ctattctagt ttcaatctac tatattttgc acattttcat
    30601 gaaaaaaatg agaactagaa ctcacattct gctctcattt ttcgtttttc cgttctccta
    30661 tcctgttttt aggagttaga aaatgctgct acctttactt actctccttt aataaagcca
    30721 atagtttttc agcttctgcc ataatagtat tgttgtcctg ggtgccaaat agtaaattat
    30781 tttttaatcc tgtgagagtc tctttggcat tggacttgat aattggatcc tggatttttc
    30841 caagtaaatc ttcagcctct ctcagttttt cttcaacctt ttcagtctcg acctgaggtt
    30901 cttctgattc ctctggtgat tcttcttctg gttcctctgt tggttttgga gactctggtt
    30961 tctcgctttg cggtttctct tctcgagggg tttcttcctc aggtttttct gtctgaggtt
    31021 tctcctcgct tggtttttcc gtttgattgg tatcagcttg accatttttg tttctttgaa
    31081 catggtc
//
LOCUS       DBMVGT010000017        30431 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.017, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000017 DBMVGT010000000
VERSION     DBMVGT010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 30431)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 30431)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..30431
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.017"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            42..674
                     /locus_tag="AC0DU4_000857"
     CDS             42..674
                     /locus_tag="AC0DU4_000857"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236845.1"
                     /translation="MSSKKHPLGEKRNHPGSKLRQGFWMVFRFGVNNWGEYFPDIVWR
                     LEGSLFECGVILQYYLGRLLFQKGNTSILCGESADEIMTFKYHSVNYNQFCNDKQKSV
                     YFSYSDYPFYVTNSIVLKKNSLLLHSFGIHPRYPYKMSEIVEMSKKISDLNDKKEFHK
                     KNCELRFQDSVLDNINSVPGTTHLFSCLNIQTLVKIILYIFRYNSCIENI"
     gene            897..1646
                     /locus_tag="AC0DU4_000858"
     CDS             897..1646
                     /locus_tag="AC0DU4_000858"
                     /EC_number="3.5.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000069862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000225 -
                     N-acetylglucosaminylphosphatidylinositol deacetylase
                     activity [Evidence IEA];
                     GO_process: GO:0006506 - GPI anchor biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
                     /protein_id="HIN4236846.1"
                     /translation="MSNNTKYIFLSPHLDDAIFSCSDYISKLTSEGEIVLVITIFSGY
                     PLSQQLQPSAKQFHKLCNLGKYPIEERKKEDRLACERLQCDFRHLSYYECLYRKDRNG
                     NFLYRHIYSELKNEDTLKNDIIKELLMHLDDKCVVYCPLSLGDHVDHVFVNSIGRALE
                     FMRYKVIYYEDFPYVSDSSMVSYMGKTKELKMYQEELDEKHYIDRISSILCYKSQILI
                     IWKSVEKLLNNIKELYLRNGAAYSIIFWIKK"
     gene            1659..2830
                     /locus_tag="AC0DU4_000859"
                     /pseudo
     CDS             1659..2830
                     /locus_tag="AC0DU4_000859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017606.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide sugar dehydrogenase"
     gene            3225..4088
                     /locus_tag="AC0DU4_000860"
     CDS             3225..4088
                     /locus_tag="AC0DU4_000860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HIN4236847.1"
                     /translation="MIERMELGEFYKELRLARKLKQSDVACEGLTASQLSKFELGQSM
                     LSADKLILAIQGINMNFDEFGHKLNNYQESPHMRIGRKVVDRFAHQDIAALEQLLEEV
                     DQEQMAQTYRRLNAIVIKNALHSLDKSYPLTEEDSEFLTTYLYAIESWTWFELYLFCN
                     TMPFLSNQDLIFLSTSLLEKSKEFKELVHNRWYMKSGYLNIISELMERKLFSYVPIFE
                     AELERMLRPYDVFEKVLWQFLKKMQIFLQTKGSNQKEIEHFIQSLQVLENPQLTALFE
                     LRLQQYKELID"
     gene            4554..7067
                     /locus_tag="AC0DU4_000861"
     CDS             4554..7067
                     /locus_tag="AC0DU4_000861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000375503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="HIN4236848.1"
                     /translation="MDRLQTMLNKIQVDTYHKNGWLFVKYSNNKLTQGWKLHVSSQLK
                     DACNIFYIVAQELEKERCNYKVLDCLDELKKLNSPREVSPTANKFITIYPSSRKQAKR
                     IILNLKEKLEKYKAPRILSDFQCGEYSPIHYRYGAFKAIKNYNFSENKIVYMMKNSRG
                     ELVEDLRLSYPYLPEGVKDLFTDMEKNKLFKPSPEIPENHPLNHYNIECILKKSNRGN
                     VYRAIEKSSNQKVIIKHARPYVYSWNDGFSAIDELKSEAANLKVFQDKSYTTDLIEEF
                     YVNEDYFVVQKFIPGYNFFDLKNIDIEKNVIINNIIDIINDIHAEGYLAVDISPTNFI
                     LDDFGRVRLIDLENFTNKNNTVRRAATKFMINTDCPSKICTIQQDYFALAMLSFAIMR
                     EHVLIFEGEDVLLNITALDKIKFCMYSEKEIGNITKSQFNWLMYLLNLSEQEKLDRFE
                     KMKYINDFEDKNIEFHLKKVDSSFNLQIENETLINYLLSLNMNRESRILNSNEFGEFV
                     SPISFQHGLSGYLFYLSHMRDISENGRIIEWIISEGNQNKGNVYLNGCSILFGSSGYL
                     WVLLEFYKKITSNNPSRELIIDKIRDIYKDLISSYQKVEVFDFALGKSGILLSLMKYC
                     INFNDVDSMEFIREKIEELYLYFVDEIRNVNSLKECNFAHGLAGIAYVILIYNSEFEF
                     KVAYENSIKVFNNLLENLLENEYSRLNATPTNLELSWCEGTSGILLYFELLYDKRYSN
                     IISRFQQLAFKFNLIQSSCYCHGLSSLLQTLNYQDKLNLRENVIEILLSRSKRDKNGI
                     LVFECEESSDTLFDFGIGNLGIYWSILGERFPFELKKEL"
     gene            7067..8293
                     /locus_tag="AC0DU4_000862"
     CDS             7067..8293
                     /locus_tag="AC0DU4_000862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HIN4236849.1"
                     /translation="MKVFLQNRDFRQLTINQWISTLGDTIFYLAFLNYVADASFAPLA
                     ILLITISETLPQVLQIFLGVLADFQHHRVLKYTVISFAKFLLYSIVSLSLSGQSFSLL
                     LVAFICLINLLSDTLSYFSGAMLTPIFIRIIGQDHLAEAIGFKQSTVSLVKTISNILG
                     GVLLGILSIQFISLLNALTFLIAFLGILFIKTDLLKVEKTINYQEGLSVKSFCQHLLQ
                     SSKLIWNMNKVLLVLFIISTSQAVINVTVPVSTLFLRNQPFLNLQTGQSLALLSTFEL
                     SALIVGSLVSGYLQHTISIKTALYASLVTQLLLLVGFATVRFDWILIFSTLDAFFAGV
                     LSPRLQELVFKQIPEESMGAVQSSIGAITVVLPSLFTIALVTIATSFGTLAVSFVLLL
                     FLLVAFVMLLNIRESI"
     gene            8741..9397
                     /locus_tag="AC0DU4_000863"
     CDS             8741..9397
                     /locus_tag="AC0DU4_000863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="AzlC family ABC transporter permease"
                     /protein_id="HIN4236850.1"
                     /translation="MPTALGYVSIGLACGTIGAPYVTPVEMGLMSLFVYAGSAQFAML
                     ALIVVQAPVAAIAMTVFLINLRLFLLSLHASTYFRHTSIWYNIGMSSILTDETYGVLM
                     GELAHTDKVNPMWMHGNNLNSYVAWFVGTVVGTALGGLLPNPEIFGLDFALVGMFIGI
                     FASQFQIMQRRIPVRNLLIILAVVAVSFFLLLTVVSQSLAVLFATLLGCSMGVVLDGQ
                     "
     gene            9387..9710
                     /locus_tag="AC0DU4_000864"
     CDS             9387..9710
                     /locus_tag="AC0DU4_000864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000253911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlD domain-containing protein"
                     /protein_id="HIN4236851.1"
                     /translation="MVSKYLLLAVIFSGLVTWILRMIPFILVKYKGLPAIVERFLKFL
                     PVSIIFALILSSVVTGKVGSLPQIKWLDFLAVFPTAWVAFRYRNLVGTVLFGVVLIAI
                     LRLVF"
     gene            9814..10644
                     /locus_tag="AC0DU4_000865"
     CDS             9814..10644
                     /locus_tag="AC0DU4_000865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4236852.1"
                     /translation="MKKIVKYSSLAALGLVAAGVLAACSGGAKKEGEAASKKEIIVAT
                     NGSPRPFIYEENGELTGYEIEVVRAIFKDSDKYDVKFEKTEWSGVFAGLDADRYNMAV
                     NNLSYTKERAEKYLYAAPIAQNPNVLVVKKDDSSIKSLDDIGGKSTEVVQATTSAKQL
                     EAYNAEHTDNPTILNYTKADFQQIMVRLSDGQFDYKIFDKIGVETVIKNQGLDNLKVI
                     ELPSDQQPYVYPLLAQGQDELKSFVDKRIKELYKDGTLEKLSKQFFGDTYLPAEADIK
                     "
     gene            10798..11652
                     /locus_tag="AC0DU4_000866"
     CDS             10798..11652
                     /locus_tag="AC0DU4_000866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000694494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HIN4236853.1"
                     /translation="MKIKKWLGLAALATVAGLALAACGNSEKKADNATTIKIATVNRS
                     GSEEKRWDKIQELVKKDGITLEFTEFTDYSQPNKATADGEVDLNAFQHYNFLNNWNKE
                     NGKDLVAIGDTYISPIRLYSGLNGSANKYTKVEDIPANGEIAVPNDATNESRALYLLQ
                     SAGLIKLDVSGTALATVANIKENPKNLKITELDASQTARSLSSVDAAVVNNTFVTEAK
                     LDYKKALFKEQADENSKQWYNIIVAKKDWETSPKADAIKKVIAAYHTDDVKKVIEETS
                     DGLDQPVW"
     gene            11752..13125
                     /locus_tag="AC0DU4_000867"
     CDS             11752..13125
                     /locus_tag="AC0DU4_000867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M20 family metallopeptidase"
                     /protein_id="HIN4236854.1"
                     /translation="MVFPSEQEQIEKFEKDHVVQHYFEVLRTLISKKSVFAQQVGLKE
                     VANYLGEIFKRVGAEVEIDESCTAPFVMAHFKSSRPDAKTLIFYNHYDTVPADGDQVW
                     TEDPFTLSVRNGFMYGRGVDDDKGHITARLSALRKYMQHHDDLPVNISFIMEGAEESA
                     STDLDKYLEKHADKLRGADLLVWEQGTKNALEQLEISGGNKGIVTFDAKVKSADVDIH
                     SSYGGVVESAPWYLLQALQSLRAADGRILVEGLYEEVQEPNEREMALLETYGQRNPEE
                     VSRIYGLELPLLQEDRMAFLKRFFFEPALNIEGIQSGYQGQGVKTILPAEASAKLEVR
                     LVPGLEPHDVLEKIRKQLDKNGFDKVELYYTLGEMSYRSDMSAPAILNVIELAKKFYP
                     QGVSVLPTTAGTGPMHTVFDALEVPMVAFGLGNANSRDHGGDENVRIADYYTHIELVE
                     ELIRSYE"
     gene            13118..14179
                     /locus_tag="AC0DU4_000868"
     CDS             13118..14179
                     /locus_tag="AC0DU4_000868"
                     /EC_number="7.4.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0033232 - ABC-type D-methionine
                     transporter activity [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0048473 - D-methionine transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HIN4236855.1"
                     /translation="MSRDIIKLDQIDVTFHQKKRTITAVKDVTIHIQEGDIYGIVGYS
                     GAGKSTLVRVINLLQKPSAGKITIDDDVIFDGKVTLTAEQLRRKRQDIGMIFQHFNLM
                     SQKTAEENVAFALKHSELSKEEKKAKVAKLLDLVGLADRAENYPSQLSGGQKQRVAIA
                     RALANDPKILISDESTSALDPKTTKQILALLQDLNQKLGLTVVLITHEMQIVKDIANR
                     VAVMQDGHLIEEGSVLEIFSDPKQPLTQDFISTATGIDEAMVKIEKQEIVEHLSENSL
                     LVQLKYAGASTDEPLLNELYKHYQVMANILYGNIEILDGTPVGELVVVLSGEKAALAG
                     AQEAIRQAGVQLKVLKGGQ"
     gene            14181..14873
                     /locus_tag="AC0DU4_000869"
     CDS             14181..14873
                     /locus_tag="AC0DU4_000869"
                     /EC_number="7.4.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033232 - ABC-type D-methionine
                     transporter activity [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0048473 - D-methionine transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter permease"
                     /protein_id="HIN4236856.1"
                     /translation="MESLIQTYLPNVYKMGWSGQAGWGTAIYLTLYMTVLSFIIGGFL
                     GLVAGLFLVLTAPGGVLENKVVFWILDKITSIFRAVPFIILLAILSPLSHLIVKTSIG
                     PNAALVPLSFAVFAFFARQVQVVLAELDGGVIEAAQASGATFWDIVGVYLSEGLPDLI
                     RVTTVTLISLVGETAMAGAVGAGGIGNVAIAYGFNRYNHDVTILATIIIILIIFAIQF
                     LGDFLTKKLSHK"
     gene            complement(14903..15472)
                     /locus_tag="AC0DU4_000870"
     CDS             complement(14903..15472)
                     /locus_tag="AC0DU4_000870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HIN4236857.1"
                     /translation="MKKSILTTLLFAVLYFLCMGIGVLLGNLFDQTGNMFYAPAFTAL
                     VGGSVYMILVAKVPRFGAITTIGLVIAFFFLGTKHGAGSFLPGIICGLLADEVAHLGK
                     YKDKTKNFLSFIIFAFSTTGPILLMWIAPKAYMATLLARGKSQEYIDRIMVAPNPGTV
                     LLFIASIVIGALVGALIGQALSKKFAQKI"
     gene            15607..16221
                     /locus_tag="AC0DU4_000871"
     CDS             15607..16221
                     /locus_tag="AC0DU4_000871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000532354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HIN4236858.1"
                     /translation="MGRFLDFVFNRFFLGMIATAFFWLLTLAGGIILGLAPASATLMS
                     LYAEHGYSFREYSLKEAWSLYKQNFVSSNLIFYSFLGVGLVLTYGLYLLVQLPHQTIV
                     HLIATLLNVLVVALIFLAYTVSLKLQVYFALSYRNSLKLSLIGIFMSLAAVAKVLLGT
                     VLLVAIGYYMPALLFFVGIGMWHFFISDMLEPVYEIIHEKLATK"
     gene            16199..17869
                     /locus_tag="AC0DU4_000872"
     CDS             16199..17869
                     /locus_tag="AC0DU4_000872"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HIN4236859.1"
                     /translation="MKNWRQNRMKQFWLHTLLRTYSSVMIIIIASFAILLSYADWDSR
                     EKEAQRVAQRVTARTVSEIEYYHRESTQIAQALVENQARIEGIYKYFSLSMPDYFYWQ
                     LERKASPYISVSLYENVDDLYVRNDFVTGVAIAFQDYKEVYVSTKDKRSGEKIRAEDF
                     KPAGNSFAIPVSDPVSDQDLGVIYISLDPAVLYHAIDNTRGHTPMAVTVTSPFDTEIF
                     HIGETVDKESENWLVGLTSHGYQVQVAVPKNFVLQGTVTSSALIVGLSLLFIVILYLT
                     LRQTFANYQKQVVDLVDSIQAIAQGQEGLRIDTLEKDQELLLIAETTNDMLDRLEKNI
                     HDIYQLELSQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLR
                     NNISDERETLLKQELEFCRKYSYLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVE
                     NYFAHGVDHRRTDNVISIKALKQDDFVEILVVDNGRGMSAEKLANIREKLSQKYFEHQ
                     ASYSDQRQSIGIINVHERFVLYFGDRYAITIESAEQAGVQYRITIQDE"
     gene            17881..19167
                     /locus_tag="AC0DU4_000873"
     CDS             17881..19167
                     /locus_tag="AC0DU4_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HIN4236860.1"
                     /translation="MYKVLLVDDEYMVTEGLKRLIPFDKWDMEVVATVSHADEALEYV
                     QENPVDVIISDVNMPDKTGLDMIREMKEILPDAAYILLSGYQEFDYVKRAMNLSVVDY
                     LVKPVDKVELGNLLEKIAGQLGERGKKSQTLSQELDEAGFVSYLGDKENWWIGLSKEK
                     QGSFAIPYYVLGQDWQIFISDQPLDGLVVTPFEAPYQEHFERWKLNAEKTLFYGSVNL
                     QQSESLFAYYEPIYRVIIQGNLNQIVEELNLLEKVVLENTPRVPITKQLFIQFVMDVF
                     HLFEHLKADDLTDIVKTIHAIQSFDELVPYIKETLSSFFGQYRMNENVVSVLEVIGRD
                     YQKELSLKDISKALFINPVYLGQLIKRETDSTFAELLNKQRIKAAQQLLLSTSDSIED
                     ICYAVGYSNLGYFYKVFRKLCGKSPKAYRKQVETIL"
     gene            19228..19761
                     /locus_tag="AC0DU4_000874"
     CDS             19228..19761
                     /locus_tag="AC0DU4_000874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4236861.1"
                     /translation="MKKKPIYLWVLLILSALISVPSLFGIVSPLPSKEALRTAQKQVA
                     GVNAQQLEDQLNYTYRVAEASHSIFNVALIVLSTILVVVAIVFLVRKNLQYANYTYVG
                     YVLLAIIGSIYGYVGLQDAVQLVQDESMRLTVSIGSKAVSIFYIVINVLFLALVFYKM
                     WRQQKALAEEEETEELA"
     gene            19839..20309
                     /gene="nrdI"
                     /locus_tag="AC0DU4_000875"
     CDS             19839..20309
                     /gene="nrdI"
                     /locus_tag="AC0DU4_000875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class Ib ribonucleoside-diphosphate reductase
                     assembly flavoprotein NrdI"
                     /protein_id="HIN4236862.1"
                     /translation="MKTISLVYISLSGNTESFVTRLKDYLLSQYKGIEVQKIHIKDLV
                     KEGKNFYEMDHPYVAFLPTYLEGGNGVDNGDVEILTTPVGDFIAYGNNASKCFGVVGS
                     GNRNFNNQYCLTAKQYSQRFGFPVLADFEMRGMLEDIKHVAAIIADLYELEKEN"
     gene            complement(20602..21864)
                     /locus_tag="AC0DU4_000876"
     CDS             complement(20602..21864)
                     /locus_tag="AC0DU4_000876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000075801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_function: GO:0046873 - metal ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NRAMP family divalent metal transporter"
                     /protein_id="HIN4236863.1"
                     /translation="MSQAISLNQSTWASKLKAMGPGILMATAAVGGSHIVSSTQAGGS
                     YGWSLLLLVILANVFKYPFFRFGAEYTADTGKTLVEGYAEKGKLYLWIFFILNVFSAM
                     VNTAGVAILCSAIIASAFPMIGLSITQWSLILVAIIWAMLLFGGYKLLDGMVKWIMSA
                     LTIATVLAVIIAAVKHPEYSSDFVEKTPWQMAALPFIVSLLGWMPAPIEISAINSLWS
                     AEKRKTVNFNTEDALFDFNTGYIGTAILAVFFVALGALIQYPTGQAVEAASAKYISQF
                     VGMYASVLGEWSRYLITFIAFLCIFGTVITVIDGYSRVNQESLRLLISQKEDNRKSLN
                     IWMTITAIIGIVIIKFFAGQVSTMLRFAMIGSFLTTPFFALLNYALVTRENKNLPSWL
                     KHLAIAGLIFLFGFAIFFIYALAIGKAG"
     gene            complement(22174..22632)
                     /locus_tag="AC0DU4_000877"
     CDS             complement(22174..22632)
                     /locus_tag="AC0DU4_000877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3021 domain-containing protein"
                     /protein_id="HIN4236864.1"
                     /translation="MKKQVFHDAATGVLIGLILSILFSLIYAPNTYAPLNPYSLIGQV
                     MDQHQVHGALVLLYCTLIWATIGMLFNFGNRLFSRDWSMLRATLTHFFLMLAGFVPLA
                     TLAGWFPFHWIFYLQLIIEFAIVYLIIWAILYKREAKKVDHINQLLEHRK"
     gene            complement(22629..23069)
                     /locus_tag="AC0DU4_000878"
     CDS             complement(22629..23069)
                     /locus_tag="AC0DU4_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000861967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="HIN4236865.1"
                     /translation="MKVELQISETYEEEKLIVQAPQETEKVQKVIEFAENLDQREKIK
                     GKIDDQVYLVEIGKIQRFYIENRKVLAETASQTYSIDLRLYQVLKLLPTNFIQISQSE
                     IINIDSISHLKLTPNGLVEIFLKNESFTYSSRRYLKTIKEKLEL"
     gene            23502..24368
                     /locus_tag="AC0DU4_000879"
     CDS             23502..24368
                     /locus_tag="AC0DU4_000879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000537001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236866.1"
                     /translation="MGTLLATRLKNRRKELKMSQRELAEGICKQGQISRLESGEFTPG
                     ADFLNALAKKLKVSMDYFFDEQVVEKVEELSEFKKLAQTFITNRNYESLKYIYELENV
                     KAHRLSLADKIYMEWIKSLIDFYFYGQKEDAIVRLEGVLSQLSVSDLNYLQVSNTLFN
                     FYYDIGDLGRFNKIREKLEYQVNHLNLSTIEELELSIKFNYNVCRYLWLQKNIEEAIT
                     KITATIKQCKAYRTNYLLADLYLLMGNVSENFSSKSSVKEYFETAYFLYKLEENMSMT
                     LKVEHYIADITE"
     gene            24522..24650
                     /locus_tag="AC0DU4_000880"
     CDS             24522..24650
                     /locus_tag="AC0DU4_000880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001257107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236867.1"
                     /translation="MRSLFKKIVAVLVIGLILLGIARTPQVHKMARGIDPGPANFI"
     gene            24706..25263
                     /locus_tag="AC0DU4_000881"
     CDS             24706..25263
                     /locus_tag="AC0DU4_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358739.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="flavoprotein"
                     /protein_id="HIN4236868.1"
                     /translation="MDKKNLLVLVTGSVGASNVDTYLYYIKKFYNVKVILSENSKKFI
                     SKELISYFCDKVYDEIFVEEVVPHVFLPYESDLLLILPATANVIGKIANGIADDLVTA
                     TVLNFNKKIIFCPNMNSTMWDNHIVQRNVSILKELGHIFLFESKKTYEVGLRKAIDST
                     CSMLQPQSLVKELIKLENIVLEEGH"
     gene            25484..26590
                     /locus_tag="AC0DU4_000882"
     CDS             25484..26590
                     /locus_tag="AC0DU4_000882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000608718.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="HIN4236869.1"
                     /translation="MINKKIQQVVLESLQNFLNGNFISPCVVYDFGLLETVLDEFKNQ
                     IPVTFNYQLFYAVKANSNEKILEFLVDKIDGVDVASLSELDVAKKFFPPTQISVNGSA
                     FSYETLYNLIKKQYKVDINFLEHLQQFSPKESVGIRVTEPDELNNRMSRFGINICSDN
                     WTSNLQNPLITRLHFHFGEKDDKFIVKLDKILFKLQEINKLREVREINLGGGFMKLFM
                     ENRLKEFFLSLMEIYKKYDIDSTVTTIIEPGSAITSFSAYMITSPVNVSEVNEQQVIT
                     LDTSIYTNTLWFVPHIITTLNSSSKERYSTILYGNTCYEHDKYKMKVSLPRLTQNSSI
                     VFFPVGAYIKSNHSNLHRNDFMREVYLWTKNLTY"
     gene            26566..27957
                     /locus_tag="AC0DU4_000883"
     CDS             26566..27957
                     /locus_tag="AC0DU4_000883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236870.1"
                     /translation="MDKKLDILDKVKEYLGNKTTQILDNQYKEFLKLNDIRRAFGISE
                     KVLNNSFNFTSKEFNDLINNENYLFEYACRIREEWRKKCFNHSYRFLCSPIITDDFLN
                     TKTLRSSQIEYKYERYLSKSSIGDRAVDGFVSFNTLTANGMSAIKLCLEILNSIFFKK
                     KIDLLYSTGYYETRFLLNNLAKSGISCYEVSNCELDKDKFYNVFMMEPNRADLTLQKT
                     DFKIVEYFVKYKNNSIKVVILDISYQGSNFKLVEFLEKFKFANVIIFVVRSLIKLDQM
                     GLELTNGGIIEVFIPNHLRKLKNFIEEEFNKFRNSHGANLSLYEYCLLDNSLTLKNDW
                     NYSDLVMKFTSNFYADIKDLFMENSDIEIIHEEGVPFVFLDLIGEGKKEYEMFFQWLN
                     FFYKQLGITLYARNSFGFRNLTVEYFGIIGTERYIFKICPGVYKGLSYYLMKFLLKSF
                     SNEYLKTTDEVNR"
     gene            27954..29132
                     /locus_tag="AC0DU4_000884"
     CDS             27954..29132
                     /locus_tag="AC0DU4_000884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000792992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HIN4236871.1"
                     /translation="MKNLIKLLIIRLIVNLADSVFYIVALWHVSNNYSSSMFLGIFIA
                     VNYLPDLLLIFFGPVIDRVNPQKILIISILVQLAVAVIFLLLLNQISFWVIMSLVFIS
                     VMASSISYVIEDVLIPQVVEYDKIVFANSLFSISYKVLDSIFNSFASFLQVAVGFILL
                     VKIDIGIFLLALFILLLLKFRTSNANIENFSFKYYKREVLQGTKFILNNKLLFKTSIS
                     LTLINFFYSFQTVVVPIFSIRYFDGPIFYGIFLTIAGLGGILGNMLAPIVIKYLKSNQ
                     IVGVFLFLNGSSWLVAIVIKDYTLSLILFFVCFMSKGVFNIIFNSLYQQIPPHQLLGR
                     VNTTIDSIISFGMPIGSLVAGTLIDLNIELVLIAISIPYFLFSYIFYTDNGLKEFSIY
                     "
     gene            29170..29533
                     /locus_tag="AC0DU4_000885"
                     /pseudo
     CDS             29170..29533
                     /locus_tag="AC0DU4_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001032902.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR family transcriptional regulator"
     gene            29557..29790
                     /locus_tag="AC0DU4_000886"
     CDS             29557..29790
                     /locus_tag="AC0DU4_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000623387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HIN4236872.1"
                     /translation="MISIDLGGTNIKITVLSNDGEIETLWSITTDTSEKGSQIISDII
                     SSIKNKLTERNIPDSDLLGIGMGSCSSYFPCKS"
     gene            30073..>30431
                     /gene="mutL"
                     /locus_tag="AC0DU4_000887"
     CDS             30073..>30431
                     /gene="mutL"
                     /locus_tag="AC0DU4_000887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0030983 - mismatched DNA binding [Evidence
                     IEA];
                     GO_process: GO:0006298 - mismatch repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HIN4236873.1"
                     /translation="MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQII
                     IEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPS
                     IASVSVLTLLTAVDGAS"
BASE COUNT         9680 a         4798 c         6236 g         9717 t
ORIGIN      
        1 tgtttttttc tacacttata ccataaaggg gaaactcttt tttgtctagt aaaaaacacc
       61 cattgggtga aaaaagaaac catccaggat ctaagctaag gcaaggattc tggatggttt
      121 ttagatttgg ggtgaataat tggggagaat attttcccga tatagtatgg agattggaag
      181 gaagtctctt tgaatgtggt gtcatactgc agtactattt aggcaggttg ttgttccaaa
      241 aagggaacac aagtattctt tgtggcgagt cagcggatga aataatgact tttaagtatc
      301 attctgtgaa ctacaatcaa ttttgtaatg ataaacagaa gtcagtatat tttagttatt
      361 ccgactatcc attttatgtt acaaattcaa ttgttttaaa gaaaaatagc ctacttttgc
      421 atagttttgg cattcatcct agatatccat ataaaatgtc tgagattgtt gaaatgtcta
      481 aaaaaatatc agatttaaac gataaaaaag aatttcacaa aaagaactgt gagttgaggt
      541 ttcaagatag tgttcttgat aacataaata gtgtcccggg tacaactcat ttatttagtt
      601 gtttaaatat tcaaacatta gtaaaaatta ttttatatat ttttcgatac aacagttgta
      661 tcgaaaatat ttaattttag agataaagag cttatctttt ttaataagat tgtaaatggg
      721 ctgatacaaa atattgagga gaatttagag gatgatattg aaaggatatt gaaatattta
      781 tatatatgtt tatttaacga aatattcatt attaagaata aggtgaattt ttttgatgat
      841 gtggaattta atcagacact tagtgagttt ttagataaat tgtagaggga atggttatga
      901 gtaacaatac taagtatatc tttttatctc cacatttaga tgacgcaatt ttttcctgta
      961 gtgattatat ttcaaaatta acttcagaag gagaaattgt acttgttatt actatatttt
     1021 ctggttaccc tttgagccaa cagctacagc cctctgctaa gcaatttcat aagttgtgta
     1081 accttgggaa atatccgatt gaagaaagga agaaagaaga caggttagct tgtgaacgtc
     1141 tacaatgtga ttttagacac ttatcgtact atgaatgtct ctataggaaa gatagaaatg
     1201 gcaattttct ataccgtcat atctatagtg aattaaaaaa tgaggacaca ttaaagaatg
     1261 atatcataaa agagctgtta atgcatttag acgataaatg tgtcgtatat tgtccgcttt
     1321 cacttggtga ccatgttgat catgtttttg tgaatagtat tggaagggcg cttgaattta
     1381 tgcgttataa agtaatatat tatgaggatt tcccatatgt aagtgatagt agtatggtta
     1441 gttatatggg aaaaactaaa gaattaaaaa tgtatcaaga ggaacttgat gaaaaacatt
     1501 atattgatag aatatcatca atattgtgct ataaatctca gattttgata atctggaaat
     1561 cagttgaaaa acttttaaac aatattaaag agttgtattt aaggaatggg gcagcttatt
     1621 ctattatatt ttggattaag aaataaggaa gtagttttat gaatatagca gtaattggtt
     1681 tggggcatgt tgggctggcc tacgcgttac tatttgcatc taaatataaa gttgttgcat
     1741 atgatataga ttctgtaaaa ataaataatt taaaaaaggg cattcttcca tctaaaaatg
     1801 aagagcttat gaagtttttt tgcgagaata acttaaatat tacttttttt gatacatttt
     1861 ctgaaattaa aaataatatt gattattata ttattgcgct tccgacagat tatgatgaga
     1921 aaattggtag ttttaataca tatgaaatcg aacaaacggt atcgaagatt ctgagggtaa
     1981 aacctaatgg aaagattatt ttaaagtcaa cagttccgat cggcttttca aacaaattaa
     2041 aaaggctgtt tgatacaaaa aatatcattt ttgtccctga atttttgaga gaaggttgtt
     2101 ctatatatga taatttatat ccaagtcgca tagttgttgg agatgagaca gttgaaggaa
     2161 gaaaaattgc agagttgttc ctttcgatta gtactcatag tactgccaat attaaaaatg
     2221 ttatgttagt ttctcctact gaagcagaag caattaagct tttttctaac acattcttag
     2281 ctctccgtgt tgctttttta atgaactaga ttcttttgct gagaggagaa gtttaaatgc
     2341 tgaagttgta ataaaaggtg tttgtttaga tccaagaatt ggaaattttt ataataatcc
     2401 ttcttttgga tttggaggat attgtcttcc caaagatact aaacaattaa aaaaagaatt
     2461 tatagaaata aatgccccag tgatagaagc gattgatatt tcaaacacaa atagaaaaca
     2521 gttcatagtt aaacaaatat tggaacgaaa gccaaagata gtaggaatat ataaattggg
     2581 gatgaaatat aattcagata attacaaaga gtcagctatt ttaagtataa ttaatgaact
     2641 attgattgtc ggtataaaaa ttttagtata tgaaccaaat ttaaacgtta gtatagataa
     2701 cgtaattttt gaaaagaatt ttgaactatt tacaaaacaa agtgatctaa ttgttgcaaa
     2761 tagatgggat aggggccttg aagcttataa agataaagtt tacacaaggg ggatctggat
     2821 aagagattaa ctattgatat taaaaaggca ataatttata aaatttgtac aaaaaaatgt
     2881 taaattttca cattttcata gtatactgtt taatagaaag taggttcttt gtaaccgctc
     2941 cattataaaa tcctttcact cttccggtat actattagga aaaacataac tggaggatat
     3001 tttgagctca cacctcatcg ttccagtggc tgttccccaa gctcgtgtac tgcccaaaaa
     3061 agttagacat tctatttaga acgaggattg agttctgtat tgtacaaggc tcggtccttt
     3121 tagagtcagc ttaaggctgg cttttttgcc ctcttaaata tcagaatatt ttgacaaatg
     3181 attgtaaata atgatataat atgcaaaagc taggaggtgg tcagatgatt gagagaatgg
     3241 aattgggaga attttacaag gaattgcgct tggcgagaaa acttaagcag tcagatgtgg
     3301 cctgtgaggg tctaacagct tctcagttgt ccaagtttga actaggacag tctatgttat
     3361 ctgcagataa gctcatatta gccatccaag ggatcaatat gaattttgat gagtttgggc
     3421 acaagctcaa caactatcaa gaatctccac atatgcgaat cggtcgaaag gttgtggatc
     3481 gctttgccca tcaggatata gctgctttag agcagctatt ggaggaagtc gatcaagaac
     3541 agatggcgca gacctatcgt cgtttgaatg ccattgtgat taaaaatgca ctccattcct
     3601 tagataaaag ctacccgcta acagaggagg atagcgagtt tttgactacc tacctctacg
     3661 ctattgagtc ttggacctgg tttgaactct atcttttttg caatactatg cccttcttga
     3721 gcaatcaaga tctgatcttt ttatcaacct ccttactcga aaaatccaag gaatttaaag
     3781 agttagtaca caatcgatgg tatatgaaaa gtggttatct taatatcatc tcagaactta
     3841 tggagcgcaa gctattttct tatgttccaa tctttgaagc tgagctggag cgcatgctcc
     3901 gtccatacga tgtttttgaa aaagtattgt ggcagttttt aaagaaaatg cagatttttc
     3961 ttcaaaccaa aggaagcaat caaaaagaga ttgaacactt tatccaatct ctgcaagtat
     4021 tagaaaatcc acaattgaca gccctttttg aattgcgttt gcagcaatac aaagagctta
     4081 tcgattagtt agaaatggga aaaagataat aatatcagca acgatcgtca ataatgttaa
     4141 aacttgtttc ttcatattac ttccctcctc attagtaata actttattat accagggaaa
     4201 taatcaaatc taccaaaatc gcaaatctga aatttctata agaaaaaata tcaaatatgc
     4261 gattttctaa aataagccaa tttccgtgtt atactgtcct tgtaaaacat ttgaagcaaa
     4321 tcctaggtcg cagaagtggt ttacaaaaaa ataatcaaag gagaaaagaa atgcataatc
     4381 taatggaact tgaattgtta cctgaagagc cagtaattac tgtatcacgg gaagtttgta
     4441 agtggacttg ctcatttact gctctttaag aataactggt taaaattaag gatagttgat
     4501 tactaattaa ctatccttaa tttcatttca gagataatgt atttattata tttatggata
     4561 gattacaaac aatgctgaat aaaatacaag ttgatactta ccataaaaat ggatggttat
     4621 ttgtgaagta tagtaacaat aaacttacac agggatggaa acttcatgta agcagtcaac
     4681 taaaagacgc ttgtaatatt ttttatattg ttgcacaaga gctggaaaag gaaagatgta
     4741 actacaaagt tctagattgt ttggatgagt taaaaaaatt aaattctcct agggaagttt
     4801 ctcctactgc aaataagttt atcactatat atccgtctag taggaagcag gccaaacgaa
     4861 taatattaaa tctaaaagaa aagttagaaa aatataaagc tccaaggatt ttatcagatt
     4921 ttcaatgtgg tgagtattct ccaatacatt atagatatgg tgcgtttaaa gcaattaaaa
     4981 attacaattt ttctgaaaat aaaattgtct acatgatgaa aaatagtaga ggagaattag
     5041 tagaagatct gagattaagt tatccatatt tgccagaagg ggttaaggat ttatttactg
     5101 atatggaaaa aaataaatta tttaaaccct ccccggaaat cccagagaat caccctttaa
     5161 atcactataa tatcgagtgt attctaaaaa aatccaatag aggaaatgtt tacagagcta
     5221 tagaaaaaag tagtaatcag aaagtgataa taaaacacgc acggccatat gtttatagtt
     5281 ggaatgatgg tttctctgca attgatgaat taaagagtga agcagcaaat ttaaaagtat
     5341 ttcaggataa gtcctataca acagatttaa ttgaagagtt ttatgtcaat gaagattact
     5401 tcgtagtaca gaagtttata ccaggatata atttttttga tttaaaaaat attgatatcg
     5461 aaaaaaatgt aatcattaat aatataattg atattattaa tgatattcat gctgagggat
     5521 atttagcagt ggatatttct ccaacaaact ttatattgga tgattttggt cgtgttaggt
     5581 taatagactt agaaaatttt acaaacaaaa acaatactgt tagaagagct gctacaaaat
     5641 tcatgataaa tactgattgt ccctcaaaaa tctgtaccat tcaacaggat tattttgcac
     5701 ttgcaatgtt gagttttgct attatgcgcg agcatgtttt aatatttgaa ggagaggacg
     5761 tcttattaaa tataactgct ttagataaaa tcaagttttg tatgtatagc gagaaagaaa
     5821 ttgggaacat aactaaatcg caatttaatt ggttgatgta tttattgaat ttaagtgaac
     5881 aagagaagtt agaccgattc gagaagatga agtatataaa cgattttgaa gataaaaata
     5941 tagaatttca tttaaagaaa gttgattcct cattcaatct tcaaattgaa aatgaaacgc
     6001 ttattaacta tcttctttcg ttaaatatga atagagaaag caggatacta aattcaaatg
     6061 aatttggaga atttgttagt ccaatatcgt ttcaacatgg cttatcagga tatttgtttt
     6121 atttatcaca tatgagagac atttctgaga atggtagaat tatcgagtgg attatctctg
     6181 aaggaaatca aaataaagga aatgtgtatc taaatggttg ttcaatttta tttggttctt
     6241 ccggatatct ttgggtatta ttagagttct ataaaaaaat taccagcaac aatccaagta
     6301 gagaattgat catagataaa attagagata tttataaaga cttgataagt agttatcaaa
     6361 aagttgaagt atttgacttt gctttaggaa agtcaggtat tttattgagt cttatgaaat
     6421 actgtataaa tttcaatgat gtcgatagta tggaatttat tagagaaaaa atagaggagt
     6481 tatatttata ttttgtagat gagatacgaa atgttaatag tttaaaagaa tgtaattttg
     6541 cacatggtct agctggaatt gcatacgtaa ttttaattta taattcggaa tttgaattca
     6601 aggtagctta cgaaaatagt attaaggtat tcaataatct gttagaaaat ttgttagaaa
     6661 atgaatatag tagactaaat gcaactccta caaatttaga actatcgtgg tgcgaaggaa
     6721 cttcaggaat cttactttat tttgagttat tatatgacaa aaggtattca aacataattt
     6781 caaggtttca acaacttgct ttcaaattca atcttatcca gtcaagttgt tattgtcatg
     6841 gcttatccag tttgttgcaa actctaaact atcaggataa attaaattta cgtgagaatg
     6901 tgattgagat tttattaagt agatccaaaa gagataaaaa tggtattttg gtatttgaat
     6961 gtgaagaaag ttcagataca ttatttgatt ttggtatcgg aaatctaggg atttattggt
     7021 ctatccttgg ggaaagattc ccatttgaac ttaagaagga gttgtgatga aagtatttct
     7081 tcaaaataga gattttaggc aattaactat caaccagtgg atttcaacgc ttggggatac
     7141 gattttttat ctggccttcc tgaattatgt ggcagatgca tcttttgccc ctttggcgat
     7201 tttactcatc acgatttcag aaaccctgcc ccaagttcta caaatctttc tgggagtttt
     7261 ggcggatttt caacatcatc gtgtcttgaa atacacagtc attagttttg caaaattttt
     7321 gctttactct atagtgtctt tatcactttc agggcagtcc ttttccttgt tattagtagc
     7381 atttatttgt ctgattaacc tcttgtctga cacgttgagt tatttttcag gcgccatgct
     7441 cactccgatt ttcattagaa ttattgggca agaccatctg gcagaagcta ttggatttaa
     7501 acagtcaact gttagtttag tgaaaacaat cagtaatatt ctaggaggag tcttattagg
     7561 tattctatcc atccagttta tttccttgct gaacgctctt acctttttaa tcgcattttt
     7621 aggtatcctc ttcataaaaa ctgacctctt gaaagtagaa aaaacgatta actatcaaga
     7681 aggactctct gtaaaatcct tttgccagca tttgctccaa tcatcgaaat tgatatggaa
     7741 tatgaataag gtgctcttgg ttttgtttat tatctctact agtcaagcag tgataaatgt
     7801 tacagttcct gtctctactc tatttttgag gaatcaaccc tttttgaatt tacaaacagg
     7861 tcaatctctt gccttgctat ccacttttga actgtcagcc ctgattgtcg gaagccttgt
     7921 aagtggctat ctgcaacata ccatttccat aaaaacagct ctctatgcct cacttgtcac
     7981 ccagttgctt cttctagtag gatttgccac agttcgtttt gactggattc tcatctttag
     8041 taccttggat gcctttttcg caggtgttct ctctcctaga ttgcaagaac tcgtttttaa
     8101 acaaatacct gaggagtcaa tgggagcagt tcaatcctct atcggtgcca ttacggttgt
     8161 tttacctagc ttatttacaa tagctttggt aaccattgct actagctttg gaactctggc
     8221 agttagcttt gttttattgc tatttcttct agttgccttt gttatgcttc tgaatattcg
     8281 tgaaagtatt tagtggagaa tttctataat atatgtttga gactggattg ccagcctttt
     8341 tatgatggtc aaaatcaaca gacttttttc tcttttctga atgtgttata atagactgaa
     8401 tctaaaatag tacgaaacaa ttgctaaaac atttatttat agaaattaat tttactttcc
     8461 caatcgattt gttctcatct tatttcaatc tgctatataa tagtccatgc tgtggctgga
     8521 ttcttttcag cctacttata ctcttcgaaa ctctcttcaa accacgtcag cttcaccttg
     8581 ccgtaggtat ggttactgac ttcgtcagtt ctatccacaa cctcaaaaca gtgttttgag
     8641 ctgactacgt cagttctatc tgcttttcat tgagtactat taagacaata tgaggagaaa
     8701 gatgaaagaa aaaggatttt aggagggggc gcaggcagcc atgccaacgg ctcttggcta
     8761 tgtcagtatc ggcctggcct gtgggactat cggtgcgccc tatgtgacac ctgttgagat
     8821 gggcttgatg agtctctttg tttatgctgg gagtgcccag tttgccatgt tggcactgat
     8881 tgtggttcaa gctcctgtgg cagctattgc tatgacggtt tttctaatca acttgcgtct
     8941 ctttttgttg agtttacacg catcgactta tttccgtcat accagtattt ggtacaatat
     9001 cggtatgtct agtatcttga cagatgagac ctatggcgtt ttgatgggtg aattggccca
     9061 tacagacaag gtaaatccta tgtggatgca cggaaacaat cttaacagct atgtggcttg
     9121 gtttgtgggg acagtagtcg gaacggctct gggtggcctg ctaccaaatc cagaaatctt
     9181 tggcttggat tttgccctgg ttgggatgtt tattggtatt tttgcttcgc aatttcagat
     9241 tatgcaaaga cggattcctg tccgcaatct gctcattatc ctagcagttg ttgcggtgtc
     9301 cttctttttg ctcttgacag tggtgtctca gtcactagct gttctgtttg cgacgctact
     9361 tggttgtagc atgggggtgg ttttagatgg tcagtaagta tcttttatta gcagttattt
     9421 tctctggctt ggtgacttgg attctccgta tgattccctt catcttagtc aagtataagg
     9481 gcttgcctgc aatcgttgag cgttttttga agttcttgcc cgtttccatt atctttgcct
     9541 tgattctttc aagcgtagtg acaggtaagg ttgggagcct tcctcaaatt aaatggctag
     9601 acttcttagc cgtctttcca acagcttggg tagcctttcg ctaccgcaat ctagtcggaa
     9661 cagttctctt tggagtggtc ttgattgcca tcttgcgttt ggtcttttaa attacccata
     9721 aaaaaaactt atcacagaga tagatatcat ataatggcgt aaatgctctt tttctgttaa
     9781 gattataagg tattctattt tggaggaaat gacatgaaaa aaatcgttaa atactcatct
     9841 cttgctgccc taggacttgt tgctgcaggt gtgcttgcgg cttgctcagg gggtgctaag
     9901 aaagaaggag aagcagctag caagaaagaa atcatcgttg caaccaatgg atcaccaagg
     9961 ccatttatct atgaagaaaa tggcgaattg actggttacg agattgaagt cgttcgcgct
    10021 atctttaaag attctgacaa atatgatgtc aagtttgaaa agacagaatg gtcaggtgtc
    10081 tttgctggtc ttgacgctga ccgttacaat atggctgtca acaatcttag ctacactaaa
    10141 gaacgtgcgg agaaatacct ctatgccgca ccaattgccc aaaatcctaa tgtccttgtc
    10201 gtgaagaaag atgactctag tatcaagtct ctcgatgata tcggtggaaa atcgacggaa
    10261 gtcgttcaag ccactacatc agctaagcag ttagaagcat acaatgctga acacacggac
    10321 aacccaacta tccttaacta tactaaggca gacttccaac aaatcatggt acgtttgagc
    10381 gatggacaat ttgactacaa gatttttgat aaaatcggtg ttgaaacagt gatcaagaac
    10441 caaggtttgg acaacttgaa agttatcgaa cttccaagcg accaacaacc gtacgtttac
    10501 ccacttcttg ctcaaggtca agatgagttg aaatcatttg tagacaaacg catcaaagaa
    10561 ctttataaag atggaactct tgaaaaattg tctaaacaat tcttcggaga cacttatcta
    10621 ccggcagaag ctgatattaa ataatttctt gaaatcatcc attctgagta aggtgggtgg
    10681 tttctcagtt tttagggata tagttttaaa ctatatatct gactatctaa taacaatttg
    10741 tgaaatcaaa caaattgtga gatactagta cggtattatt tttaaggaga aagaatcatg
    10801 aaaatcaaaa aatggcttgg cctagcagcc cttgctacag tcgcaggttt ggctcttgca
    10861 gcttgcggaa actcagaaaa gaaagcagac aatgcaacaa ctatcaaaat cgcaactgtt
    10921 aaccgtagcg gttctgaaga aaaacgttgg gacaaaatcc aagaattggt taaaaaagac
    10981 ggaattacct tggaatttac agagttcaca gactattcac aaccaaacaa agcaactgct
    11041 gatggcgaag tagatttgaa cgctttccaa cactataact tcttgaacaa ctggaacaaa
    11101 gaaaacggaa aagaccttgt agcgattgga gatacttaca tctctccaat ccgcctttac
    11161 tcaggtttga atggaagtgc caacaagtac actaaagtag aagacatccc agcaaacgga
    11221 gaaatcgctg taccgaatga cgctacaaac gaaagccgtg cgctttactt gcttcaatca
    11281 gctggcttga ttaaattgga tgtttctgga actgctcttg caacagttgc caacatcaaa
    11341 gaaaatccaa agaacttgaa aatcactgaa ttggacgcta gccaaacagc tcgttcattg
    11401 tcatcagttg acgctgccgt tgtaaacaat accttcgtta cagaagcaaa attggactac
    11461 aagaaagcac ttttcaaaga acaagctgat gaaaactcaa aacaatggta caacatcatt
    11521 gttgcgaaaa aagattggga aacatcacct aaggctgatg ctatcaagaa agtaatcgca
    11581 gcttaccaca cagatgacgt gaaaaaagtt atcgaagaaa catcagacgg tttggatcaa
    11641 ccagtttggt aataagaaac agggaggtgg gagagaaaat tccacctctt gcttttgtat
    11701 agagtataga ttgtaaagaa gactattcgt tcatagaaag gtggagagaa tatggttttt
    11761 cctagcgaac aagaacagat tgaaaaattt gaaaaggatc atgtagtcca acattatttt
    11821 gaggttttgc gtaccttgat ttctaagaaa tcagtctttg cccagcaggt tggactcaag
    11881 gaagtcgcaa attatctggg tgagattttc aagcgtgttg gagctgaagt ggagattgat
    11941 gagagctgta cagcgccctt tgtcatggca catttcaaga gttcgcgtcc agatgccaag
    12001 accttgattt tctataacca ctatgacact gtgccagcgg atggggatca ggtctggaca
    12061 gaggatcctt ttacgctttc ggtccgcaat ggcttcatgt atgggcgtgg ggttgatgac
    12121 gacaagggtc atatcacagc tcgcttgagt gctttgagaa aatatatgca gcaccatgat
    12181 gatttacctg tcaatatcag ctttatcatg gagggagcgg aggaatcggc ttcaacagac
    12241 ctagataagt atttggaaaa gcatgcagac aaactccgtg gggcggattt gttggtctgg
    12301 gaacaaggga ccaaaaatgc cttggaacag ctggaaattt ctggtggcaa taaggggatt
    12361 gtgacctttg atgccaaggt aaaaagcgct gatgtggata tccactcgag ttatggtggt
    12421 gttgtggaat cagctccttg gtatctcctc caagccttac agtctcttcg tgctgcggat
    12481 ggccgtatct tggttgaagg cttgtacgaa gaagtacaag agcccaatga acgagaaatg
    12541 gccttgctag aaacttatgg tcaacgaaac ccagaggaag ttagtcggat ttatggattg
    12601 gagttgcctc tcttacagga ggatcggatg gcctttctaa aacgtttctt tttcgagcca
    12661 gcgcttaata tcgaaggaat ccagtctggt tatcaaggtc agggtgttaa gactatttta
    12721 cctgcagaag ccagtgccaa gctagaggtt cgtctggttc cgggcctaga accgcatgat
    12781 gttctggaaa aaattcggaa acagctagac aaaaatggct ttgataaggt agaattatac
    12841 tataccttgg gagagatgag ctatcgaagc gatatgagcg caccagccat tctcaatgtg
    12901 atcgagttgg ccaagaaatt ctatccacag ggcgtttcag tcttgccgac gacagcgggg
    12961 acaggaccta tgcatacggt ctttgatgcc ctagaggtac caatggttgc attcggtcta
    13021 ggaaatgcca atagccgaga ccacggtgga gatgaaaatg tgcgaatcgc tgattattac
    13081 acccatatcg aattagtaga ggagctgatt agaagctatg agtagagata ttatcaagtt
    13141 agatcagatc gatgtgactt ttcaccaaaa gaagagaacc atcacagcgg ttaaggatgt
    13201 gaccattcac atccaagaag gggatatcta cggaatcgtt ggatattctg gagcagggaa
    13261 atcaaccctt gtacgggtga ttaatctctt gcaaaaacca tctgcaggga aaattaccat
    13321 tgacgacgat gtgatttttg atggtaaggt caccttgacg gcagagcagt tgcgtcgtaa
    13381 acgtcaagat atcggaatga ttttccagca ttttaacctg atgagccaaa agacagcaga
    13441 ggagaatgta gcctttgccc ttaaacactc tgaactcagc aaggaagaaa agaaggctaa
    13501 agtagctaag ttgttggact tggttggttt ggcagatcgt gctgaaaact acccttcaca
    13561 actatctgga gggcaaaaac agcgtgtggc aattgcgcgt gccttggcca atgatccaaa
    13621 aatcttgatt tcagacgagt caacttctgc ccttgatccg aagacaacca agcagatttt
    13681 ggccttgttg caagatttga accaaaaatt aggcttgact gttgtcttga ttacgcatga
    13741 aatgcagatt gtcaaagaca ttgccaaccg tgtggcggtt atgcaggatg ggcatttgat
    13801 tgaagagggt agtgtgcttg aaatcttctc agaccctaaa caacctttga ctcaagactt
    13861 tatctcaaca gctacaggta ttgacgaagc catggtcaaa atcgagaagc aagaaatcgt
    13921 ggaacacttg tctgaaaaca gtctcttggt gcaactcaag tacgctggag cttcaacaga
    13981 cgagccactt ttgaatgaat tgtacaagca ttaccaagta atggctaata ttctctatgg
    14041 gaatatcgaa attctcgatg gtactcctgt tggagaattg gtggtggtct tgtcaggtga
    14101 aaaagcagcg ttggcaggtg cccaagaagc tattcgtcaa gcaggcgtac agttaaaagt
    14161 attgaaggga ggacagtaag atggaatcat tgattcaaac ctatttgcca aatgtctata
    14221 agatgggttg gtctggtcag gcaggctggg gaacagctat ctacctaacc ctctatatga
    14281 cagttctttc ctttatcatc ggaggcttct tggggctagt ggcaggtctt ttccttgtct
    14341 tgacagcgcc aggtggtgtc ttggagaata aagtcgtatt ctggatttta gacaaaatta
    14401 cctcaatttt tcgtgcggtt ccctttatca tcctcttggc aatcttgtca ccactttctc
    14461 acttgattgt taaaacaagt atcgggccaa atgcagccct tgtcccactt tcttttgcag
    14521 tctttgcctt ctttgcccgt caggtgcagg ttgtcttggc tgaattggat ggcggtgtta
    14581 ttgaggcggc tcaagcgagc ggagcgactt tctgggacat cgtgggtgtt tacctatcag
    14641 aaggtcttcc agatttgatc cgtgtgacga ctgtgacctt gatttccctt gttggggaaa
    14701 cagctatggc cggtgcggtt ggagctggtg gtatcggtaa cgtagccatc gcttatggat
    14761 ttaaccgcta caatcacgat gtgaccatct tggcaaccat tattatcatt ttgattatct
    14821 ttgcaatcca attcttggga gatttcttga ctaagaaatt gagccataaa taaaaaagag
    14881 ccgcgtggct ctttttaact gatcagattt tctgtgcaaa ttttttactc aaggcttgtc
    14941 caatcaaagc acccactagg gctccgatga caatacttgc gataaataga aggacagttc
    15001 cagggtttgg agcgaccatg atacggtcga tatattcttg ggattttcct cttgccagaa
    15061 gagtagccat ataggctttg ggcgcaatcc acataagcaa gattggtcct gttgtactaa
    15121 aggcgaaaat aatgaaagaa aggaagttct ttgttttgtc cttgtatttt cctaaatgag
    15181 ctacttcatc tgctaggagg ccacagataa ttccaggaag gaaggaacca gcaccgtgtt
    15241 tagttcccaa gaaaaagaag gcaatgacaa ggccgatagt ggtaatggct ccaaagcgcg
    15301 gaacttttgc gactaggatc atatagacgc taccgccgac aagggcagta aaggcaggcg
    15361 cataaaacat gtttccagtt tggtcaaaga gattgcccaa aaggacacca atccccatgc
    15421 agaggaagta aagaactgca aaaagcagtg tagttaagat agatttcttc atgaattgtc
    15481 tcctgataat tttttcacaa ttctcatttt accatggttt ggtgggattg taaatggata
    15541 ctagaagttt ttgaaaacgc ttgaaatatg atataatggt ttcatagtta tttttagggg
    15601 aatatcatgg gtagattttt agactttgtc tttaatcgtt tctttttagg gatgattgcg
    15661 acagccttct tttggctatt aactttagca ggagggatta tccttggtct agcgccggct
    15721 agtgccacct tgatgagctt atatgcagaa catggttata gctttcggga atacagtttg
    15781 aaggaggctt ggtctcttta caagcaaaat tttgtctcaa gcaacctgat tttctatagc
    15841 tttttaggtg tgggtctagt tttgacctat ggtttgtatc tcttggtgca attgcctcat
    15901 cagaccattg ttcatttgat tgcgaccctt ttgaatgtcc tagtagttgc cctgatcttt
    15961 ttggcttata cagtatcttt aaaattacaa gtttattttg ccttgtccta tcgaaatagt
    16021 ctcaaattat ccttgattgg catctttatg agtctagcag ctgtggccaa ggttctcctt
    16081 gggactgtgc tacttgtagc aattggttac tatatgcctg ccctgctatt ttttgtagga
    16141 attgggatgt ggcatttctt tatcagtgat atgttggaac ctgtctatga aatcatccat
    16201 gaaaaattgg cgacaaaata gaatgaagca gttttggcta catacgcttc taagaaccta
    16261 tagttcagtg atgatcatta tcattgcgag ttttgcaatc ttactctctt acgctgactg
    16321 ggattcacgt gaaaaggaag cccagagagt agcccagcgt gtaactgcta gaacagtgag
    16381 tgaaattgaa tattaccata gagagtcaac ccagatagct caggctttag ttgaaaatca
    16441 agctcgtatc gagggaatct ataaatactt tagccttagc atgccagact atttttactg
    16501 gcaattagag cggaaagctt cgccttatat atcagtctct ctgtatgaaa atgttgatga
    16561 cctctatgtt cgaaatgatt ttgtaactgg ggtggccatt gcttttcaag attacaagga
    16621 agtctatgtt tctactaaag acaaacgtag tggagaaaaa atcagggctg aggatttcaa
    16681 accagcagga aatagttttg ccattccagt gtcagatcca gtgtcagatc aagacttagg
    16741 agtgatttac atctccttgg atcctgctgt tctataccat gccattgata atactagagg
    16801 tcatactccg atggcagtaa cagtgacctc accttttgat acggagattt ttcatattgg
    16861 tgagacagtt gataaggaga gtgaaaattg gctagttggc ttaacttctc atggttatca
    16921 ggttcaggtg gcagttccca aaaactttgt tttacaagga acggtgacca gctctgcttt
    16981 gattgtgggc ttgagccttc tctttattgt cattctttat ctgactttga ggcagacctt
    17041 tgctaattat caaaagcagg tagtggattt ggtggattcc atccaagcta ttgcccaagg
    17101 acaagaaggt cttcgcattg atacgcttga aaaggatcag gaattgctcc taatcgcgga
    17161 gacgaccaat gatatgttgg atcgattgga aaagaatatc catgatattt accagttaga
    17221 gcttagtcaa aaagatgcca atatgcgagc cttgcaggcg caaatcaatc ctcattttat
    17281 gtataatacg ctggagttct tgcgcatgta tgcagttatg cagagtcaag atgagttggc
    17341 agatatcatt tatgaattca gtagtctctt gcgtaacaat atttccgacg aaagagagac
    17401 cctcctcaaa caggaattag aattttgccg taaatacagc tatctctgca tggttcgcta
    17461 tcccaagtcc attgcctatg gtttcaagat agatccagag ttagagaata tgaagattcc
    17521 caagtttacc ttgcaaccgc tggtagaaaa ctatttcgcg catggtgttg accacaggcg
    17581 gacagataat gtgattagca tcaaggctct taaacaggat gattttgtgg aaattttggt
    17641 ggtcgataat ggtagaggaa tgtcggctga aaagttggca aatatccgag aaaaattaag
    17701 tcagaaatat tttgaacacc aagccagcta cagtgatcaa aggcagtcta tcggaattat
    17761 caatgtacac gagcgttttg tgctctattt tggagaccgc tatgccatta cgatagagtc
    17821 tgcagagcaa gccggtgttc agtatcgtat tacaattcaa gatgagtaga aagggagaaa
    17881 atgtataaag tattattagt agatgatgag tacatggtga cagaaggtct gaagcgtttg
    17941 attccctttg ataagtggga tatggaggtc gtcgcaacag tcagtcatgc cgatgaagct
    18001 ctagaatatg ttcaggaaaa tcctgtcgat gtcatcattt ccgatgtcaa tatgccagac
    18061 aaaacagggc ttgatatgat tcgggagatg aaagagatct taccagatgc tgcctatatc
    18121 ctgctctcag gttatcagga gtttgattat gtaaaaagag caatgaacct tagtgtggtg
    18181 gactatttgg tcaagcctgt tgataaggta gagctgggaa atctgctgga gaagattgca
    18241 ggtcagctcg gcgagagagg gaagaaaagt cagactctta gtcaagaatt agacgaggct
    18301 ggatttgtta gttatttagg ggataaggag aattggtgga taggtctatc caaggaaaaa
    18361 caaggttcct tcgccattcc ctactatgtc ttgggccaag actggcagat tttcatttct
    18421 gaccaacccc tagatggttt agtcgttaca ccttttgaag ctccttatca agaacacttt
    18481 gaacgctgga agctgaatgc tgagaaaacc ctcttttacg gttctgtaaa tctgcagcag
    18541 tctgagagtc tctttgccta ttacgaaccg atttataggg ttatcattca gggaaatctc
    18601 aatcaaatcg tagaagagtt aaatctcttg gagaaggtag ttcttgaaaa tacgccgcgt
    18661 gttccgatta ctaaacagct ttttattcag tttgtcatgg atgttttcca tttatttgaa
    18721 catctcaaag ctgatgacct gacagacatc gtcaaaacca ttcatgctat tcaatccttc
    18781 gatgaattgg ttccttatat caaggaaact ctgagcagct ttttcggtca ataccgtatg
    18841 aatgaaaatg tggtcagtgt gctggaagtc attggtcgtg attaccaaaa agagctttcc
    18901 ctcaaggata tcagtaaggc tctctttatc aatcctgtct atctagggca gttgattaag
    18961 cgtgaaaccg attcgacttt tgcagagtta ctaaacaaac aacgtattaa ggctgcccaa
    19021 caacttttgc tttcaactag tgacagcatc gaagatattt gttatgctgt tggttacagt
    19081 aaccttggat atttctataa agttttccga aaattgtgcg gaaaatcgcc aaaagcctac
    19141 cgaaaacagg tagaaactat actataagat ttgtattcct ttacaaaatg tgctataata
    19201 taaatattat tattaggagg ttctatcatg aaaaagaaac caatttatct atgggtcttg
    19261 ctaatcttgt ctgcccttat ttcagttccg tctctgtttg gaattgtgag tcccttgcct
    19321 agtaaagaag cccttcgtac tgctcagaaa caagttgcag gggtcaatgc tcagcaatta
    19381 gaagaccagc ttaattatac ctatagagta gcagaagcat ctcattctat ttttaatgtt
    19441 gctttgattg tgctatctac tattttagtg gtcgtagcga ttgtcttcct tgttcgtaaa
    19501 aatttgcaat atgcaaacta tacttacgtt ggctatgttt tgttagctat tattggttcg
    19561 atttatggct atgttggttt acaagacgct gtgcagttgg ttcaagatga gagcatgcgt
    19621 ttgacagtga gtattggttc aaaagctgtt agcattttct atatcgtcat caatgttctc
    19681 ttcctagccc ttgtcttcta taagatgtgg cgacaacaga aagccttggc agaagaagag
    19741 gaaacagaag agcttgccta agtattgaca aaaaagaact atcaagatac aatcttggta
    19801 gttgtttttt gattatagat aaaatcatgg aggtacatat gaagacaatt tctttagttt
    19861 atattagttt gagtggcaac actgaaagtt ttgtgacgcg cttgaaagac tatctcttgt
    19921 cccagtacaa agggattgag gttcaaaaga ttcatatcaa ggatttggtc aaggaaggca
    19981 aaaatttcta tgaaatggac catccctatg tcgctttttt gccgacctat ctcgaaggtg
    20041 ggaatggcgt ggataacgga gatgttgaga ttttgacgac accggtggga gattttattg
    20101 cctatggtaa caatgctagt aagtgttttg gtgtggttgg gtcaggaaat cgtaacttta
    20161 ataaccaata ctgcctaaca gccaagcaat acagtcaacg ctttggcttc cctgtattgg
    20221 ctgactttga aatgcgaggc atgctggaag atatcaaaca tgtcgcagct attatcgcag
    20281 atttgtatga gttggaaaag gagaattaat actcaatgaa aatcaaagag caaactagga
    20341 agctagtcgc aggttgctca aagcacagct ttgaggttgc agatagagct gacgtggttt
    20401 gaagagattc tcgaatagta taaagttctt ataagaggtg gttgaagttg ttcaactgtt
    20461 ttttgagtat aaacagtttt taagaacgta aaaaagcata agttcaggtc ttcaaaacct
    20521 tgttcttatg ctttttatca tagaaatatt tgctgaattt tctcttgaaa tgaaacctta
    20581 tcttcatctc gcgcttgtcc cttaccctgc ttttccgatt gcgagtgcgt agataaagaa
    20641 gatggcgaag ccaaagagga aaatcaatcc cgcaatggca aggtgtttga gccaagaagg
    20701 aagatttttg ttttcacgcg ttaccaaggc gtaattcaaa agagcaaaga aaggtgttgt
    20761 caggaaagaa ccaatcatgg caaagcggag catggttgaa acctgaccag cgaagaactt
    20821 gataatgacg ataccgatga tagcagtgat ggtcatccag atgttcaaag atttacgatt
    20881 gtcctctttt tgactgatta gcagtcggag agattcctga ttaacgcgag aatagccatc
    20941 gataacagtt ataactgttc caaagataca gaggaaggca ataaaggtaa tcaagtaacg
    21001 ggaccattcg ccaagaacag aggcatacat gcccacgaat tgagagatgt atttggctga
    21061 agcagcttca accgcctgcc ctgtaggata ctgaatcagt gctcccagtg ccacaaagaa
    21121 gacggctagg atagctgttc caatataacc agtgttaaag tcaaacagag cgtcttctgt
    21181 gttaaagttg acggtctttc tcttttcagc tgaccaaagt gaattgatgg ctgaaatttc
    21241 aataggagcc ggcatccatc ctaggaggga gacgatgaag ggcagagctg ccatttgcca
    21301 aggtgtcttc tcgacaaaat cagaactgta ttctggatgc ttgaccgccg caatgataac
    21361 tgcaagaaca gtcgcaatgg ttaaggcaga cataatccat ttgaccatgc cgtctaaaag
    21421 tttgtagcct ccaaagagta gcatagccca aatgattgca acgagaatga gggaccactg
    21481 agtaatgcta agtccaatca ttgggaaggc actggcgatg atagctgagc acagaatggc
    21541 aacaccagcc gtgttgacca tagccgaaaa gacattgagg ataaagaaaa tccagagata
    21601 gagttttcct ttttcggcat aaccttcaac caaagtcttt ccagtatcag ctgtgtattc
    21661 agcaccaaaa cggaaaaatg gatatttaaa gacattggct aagatgacca agagaagtag
    21721 agaccaaccg taagaaccgc cagcttgagt tgaggataca atgtgggaac ctccaacagc
    21781 ggcagttgcc attaggattc caggtcccat tgcttttagc ttgcttgccc aggttgattg
    21841 atttaaggaa atagcttgcg acatgataaa tactcctttt tgaattttca gaataatctg
    21901 tatatgtaat ctatattcta caaaaaattt tggaaaaatg caagagtatt ttgaaaaaag
    21961 atagaaaatt tacaaagaaa atctgaaata actgttatga tatagaggat tgaaactaga
    22021 atagtacacc tctgcttcta aaacattgtt agaaatcgat ttgactgtcc tgatcgattt
    22081 atcctgttct tatttcattt cactatagta aggtgcagca ggataaagaa aatccgagaa
    22141 gtttctttct cggatttgct tattatgagg ttcctatttt ctatgctcca agagttgatt
    22201 gatgtgatct acttttttag cctctctttt atagagaata gcccagatga tgagatagac
    22261 aatcgcaaac tcgataatga gctggaggta gaaaatccag tggaaaggga accaaccagc
    22321 aagagttgct agtgggacaa agccagccag cataaggaag aaatgagtca gagtggcacg
    22381 aagcatgctc cagtcacggc taaataagcg gttgccaaag ttgaagagca taccgatggt
    22441 tgcccatata agtgtgcagt agagcaagac cagggcaccg tgaacctgat gctgatccat
    22501 cacttggccg atgagagagt agggatttag tggtgcgtag gtatttggtg cataaatgag
    22561 tgaaaagagg atagagagga tgaggccgat aagaacaccg gtagctgcat cgtgaaatac
    22621 ttgttttttc atagttctaa tttctccttg atggttttta gataacggcg tgaagagtag
    22681 gtgaagcttt cgtttttcaa gaaaatttct accagaccgt ttggcgtgag cttgaggtga
    22741 gagatggaat cgatattgat gatttctgat tgggaaattt ggataaaatt ggttggcaag
    22801 agtttaagaa cctgatagag tcgcaaatca atgctgtagg tctgactcgc ggtttctgct
    22861 agaaccttcc gattctcgat atagaagcgc tgaatcttgc caatctcaac tagatagacc
    22921 tgatcatcga tttttccttt gattttttct ctttggtcca gattttctgc gaactcgatg
    22981 actttctgga ctttttcggt ttcttgaggt gcttggacaa tcagcttttc ctcctcgtaa
    23041 gtctcactaa tctgtagttc tactttcata gttttctctc cttttcagtt atacaaggtt
    23101 gtgatcactt cctgtatatc cttattaaac actattttat agcccatggc aaggaacctt
    23161 gtctatgtgg agggattggg ctcctatgtg gtggagcttt tctgttcttt ctgaaatatg
    23221 gtataatagc actaatcaat ttctaggaaa atagatacgg aaaggggctg aaagaactag
    23281 gggaacagtt ggaattagaa agtgataggt atgaaaagtg gcgttgaagc tgaataagtt
    23341 tataaagcgt ttgaatgaag aaatggaaag taaataagtt gacgatgaat tacaaaatag
    23401 attttatcta caatttgtat ctttcaaatc attgatttga attttagatt taatcatgtt
    23461 acaattaaaa ctgaaatcaa atagaagagg aaaatgcaaa cgtgggcaca ctattagcaa
    23521 caagattaaa aaatagacgg aaagaattaa aaatgtctca gcgagaacta gctgaaggta
    23581 tctgtaaaca ggggcaaatc agtcgattag agagcggaga gtttacccct ggagcggatt
    23641 tcctgaatgc ccttgctaag aagttaaaag tcagtatgga ttattttttt gatgagcagg
    23701 ttgtagagaa agttgaggag ttatcagaat ttaagaaatt agcacagaca tttattacaa
    23761 atcgcaatta tgagtctttg aaatatatat atgaattgga gaatgtaaaa gctcaccgcc
    23821 tatctttagc agataaaatc tacatggaat ggataaaatc tctgatagat ttttattttt
    23881 acggacagaa agaagatgcg attgtacgat tagagggggt attatcacag ttaagtgtat
    23941 ctgatttgaa ctatctccaa gtttcaaaca ccctattcaa tttttattat gatattggag
    24001 atttaggtcg tttcaataaa attcgtgaaa aactagagta tcaagtaaat cacctcaatt
    24061 tgagtacaat cgaagagtta gaactatcta ttaagtttaa ctacaacgtt tgtcgttatc
    24121 tatggttaca gaaaaatatt gaagaagcta ttactaaaat tacagctact ataaaacaat
    24181 gtaaggctta cagaacgaat tatcttttgg ctgatttgta cttattgatg ggaaatgtaa
    24241 gtgaaaattt ttcttctaaa agttcggtga aagaatattt tgagacggca tattttctat
    24301 acaaacttga ggagaacatg tcaatgactc tgaaagttga gcattacatt gcagatataa
    24361 cagaataatg aatacggtgt tcaagtgagc atcgtttttc aaacctagtt cagatacaaa
    24421 aaaagtatca aacaaaaaaa aataaaaaaa cattataaaa acaattgaca agctaatttt
    24481 gaagtgataa attaaatgca agaaaacaaa aggagaggta tatgagaagt ttgtttaaga
    24541 aaatagttgc tgtattagtt attggcttaa ttctgttagg aattgcgaga acacctcaag
    24601 ttcataagat ggctagaggg attgatcctg gtcctgcgaa ttttatttag aaatcaattt
    24661 ctactaattg agtactaatt gagtattaat gggtaaaaag attgtatgga taagaaaaat
    24721 ttacttgtat tggttactgg ttcggtaggt gccagtaatg tagatacata cttatattat
    24781 ataaaaaaat tctataatgt taaagtgata ctttctgaaa attctaaaaa atttataagt
    24841 aaggaattaa ttagttattt ttgtgataaa gtttatgatg aaatatttgt tgaagaggta
    24901 gttccgcacg tttttctgcc atatgaatct gacttacttc ttattttacc agctacggca
    24961 aatgtgattg gcaaaattgc taatggtatt gctgatgatt tagttacagc aactgtttta
    25021 aactttaata aaaaaataat tttttgtccc aatatgaact ctactatgtg ggacaatcac
    25081 atagttcaaa gaaatgtatc aattctaaag gagttgggac atatattttt atttgagtct
    25141 aaaaaaacat atgaggtagg attgcgtaaa gcaatagatt caacatgttc aatgttacaa
    25201 ccacagtcgt tagtaaaaga acttatcaaa ttagaaaata ttgtccttga agagggacat
    25261 taaaaactac tgagaatatt aaggagggga aaaaatggaa aattcatcaa tcgatgtaga
    25321 tatgctgttg gaagaattga cacaagaagc aatggtcgtt gttgctgttg ataaggactg
    25381 ttaatttaaa cttatggcaa tatatgaaag gttactggat gttttaaatt atgcaggcag
    25441 tagcctttta ttatatacaa atggataaag taaggataat acaatgatta ataaaaaaat
    25501 acaacaagtt gttttggaat cattacagaa ttttttgaat gggaacttca tttcgccttg
    25561 tgtagtctat gattttggct tgctggaaac tgtacttgat gaatttaaaa atcaaattcc
    25621 tgtaacattc aattaccaac ttttttatgc cgttaaagca aattcaaatg agaagatact
    25681 tgaattctta gtagataaaa ttgatggagt tgatgtggcg tcattatctg aattagatgt
    25741 ggctaaaaaa tttttcccac caactcaaat ttctgttaat ggttccgcat tttcttatga
    25801 aactttatat aatctgatta aaaaacaata taaagttgat attaactttt tggaacatct
    25861 tcaacaattt tccccaaaag aatctgttgg aataagagta acggagccag atgaacttaa
    25921 taatcgtatg agtcgatttg gaataaatat ttgcagtgat aattggacta gtaatttaca
    25981 aaatccttta attacacgac tgcattttca ttttggagaa aaagatgata aatttattgt
    26041 taagttagat aaaatattat ttaagttaca agaaattaat aaacttagag aggttagaga
    26101 aataaatctt ggaggcggtt ttatgaaatt atttatggaa aatcgtttga aagaattttt
    26161 tctatcactt atggaaatct ataaaaagta cgatattgat agtactgtga ctacaataat
    26221 agaaccaggt agtgcaatta cttcattttc tgcctatatg attactagcc cagttaatgt
    26281 tagtgaggtg aatgagcagc aggttatcac gttagacaca tcaatataca ccaatacatt
    26341 atggtttgtt ccgcatatta ttacaacgtt aaattcaagt agtaaagagc gttatagtac
    26401 tattctctat ggtaatacct gttatgaaca tgacaagtat aaaatgaaag tttcgcttcc
    26461 aaggttaact caaaatagca gtatagtgtt ttttcctgta ggagcttata taaaaagcaa
    26521 tcattcaaat ttacatcgta atgattttat gcgggaggta tatttgtgga caaaaaactt
    26581 gacatattag ataaagttaa ggaatattta ggaaataaaa ctactcaaat tctggataat
    26641 caatataaag aatttttgaa acttaatgat ataaggcgag cgtttggtat ttcagaaaaa
    26701 gtattaaaca attcttttaa ttttacgagt aaagaattta atgatttaat taataacgaa
    26761 aattatttat tcgaatatgc atgtagaatt agagaggaat ggagaaaaaa atgctttaat
    26821 cattcttatc gttttctatg ctcacctata attacagatg attttcttaa cacgaagaca
    26881 ttgagaagta gccaaattga atataaatat gagcgatatt tatcgaaaag ttcgataggc
    26941 gatagagcgg ttgatggctt tgtttccttc aatactttaa cagctaatgg tatgtctgct
    27001 attaaactat gtcttgagat attaaactct attttcttca agaagaagat tgatttatta
    27061 tattcaaccg gatattatga aacaagattt ttattaaata atcttgctaa atcaggtatt
    27121 agttgctatg aggtaagtaa ttgtgaattg gataaagata aattttataa tgtattcatg
    27181 atggaaccca atcgagccga tttaacatta caaaaaactg atttcaagat agtagaatat
    27241 tttgttaagt ataaaaataa ttcaataaaa gtcgttattt tagatatttc atatcaaggt
    27301 tctaatttta aattagtaga atttttagag aaatttaaat ttgcgaatgt aattattttt
    27361 gtggtacgat ctttgataaa attagatcaa atgggattag aattgacaaa tgggggaata
    27421 atagaagtgt ttattcctaa tcatttgaga aagttgaaaa attttattga agaggaattc
    27481 aataaattta gaaattctca cggagctaat ctaagcctct atgaatactg tttgcttgat
    27541 aattctttaa ctttaaaaaa tgattggaac tattctgatt tagttatgaa atttacgagt
    27601 aatttttatg ctgatataaa agacttgttc atggaaaatt ctgatattga aatcatccat
    27661 gaagagggag taccttttgt atttttagat ttaataggtg aaggtaaaaa agaatatgaa
    27721 atgttttttc aatggttaaa cttcttttac aaacagcttg gaatcacatt gtatgctaga
    27781 aatagttttg ggtttcggaa tctaacagta gagtattttg gaattattgg gacagaaaga
    27841 tatatattta agatttgtcc aggtgtttat aaagggttaa gttattattt gatgaaattt
    27901 ttattaaaat ctttttcaaa tgaatattta aaaactactg atgaggttaa tagatgaaaa
    27961 atttgataaa gttgctaata attagattga ttgttaactt agcagacagt gtattttata
    28021 tagtagcatt gtggcacgtt agcaataatt attcttcgag catgttctta ggaatattta
    28081 ttgcagtaaa ttatctaccg gatttgttac taatcttttt tggaccagtt attgacagag
    28141 taaatccgca aaaaattctt ataatatcaa ttttggttca attagcagtg gctgtaatat
    28201 ttttattatt attaaaccaa atatcatttt gggtgataat gagtctagtg tttatttcag
    28261 taatggctag ctccataagt tacgtgatag aagatgtgtt gattcctcaa gtggtagaat
    28321 atgataagat tgtatttgca aattctcttt ttagtatttc gtataaagta ttagattcta
    28381 tttttaattc attcgcatca tttttacagg tggcagtagg atttatttta ttggttaaga
    28441 tagatatagg catattttta cttgctctat ttatattgtt gttgttaaaa tttagaacta
    28501 gcaatgcgaa tatagaaaac ttctctttca aatattacaa gagagaagtg ttgcaaggta
    28561 caaagtttat tttaaataat aaattattat ttaaaaccag tatttcttta acgcttataa
    28621 acttttttta ttcatttcag acagtagttg taccgatttt ttctattcga tattttgatg
    28681 gtccgatttt ttatggtatt tttttaacta ttgctggttt gggtggtata ttgggaaata
    28741 tgctagcgcc aatcgtaata aaatatttaa aatcgaatca aattgttggt gtatttcttt
    28801 ttttgaacgg ctcaagttgg ttagtagcaa ttgttataaa agactatact ttatcactta
    28861 ttttattttt cgtttgtttt atgtctaaag gagtcttcaa tattattttt aattcgttgt
    28921 accaacaaat acctccacat caacttcttg gtagggtaaa tactaccatt gattctatta
    28981 tttcttttgg aatgccaatt ggtagtttag ttgcaggaac gcttattgat ttgaatattg
    29041 aattagtgtt aattgctatt agcatacctt attttttgtt ttcttatatt ttttatacgg
    29101 ataatggatt gaaagaattt agtatatatt agaaatgttt atgttcattc aaaagcataa
    29161 tgactataac tgaaaaagaa aagtgatatc tttaaggttg ttcttcttgg tggtgagatt
    29221 cgtgagacaa cccaagcttt tgtcggaaag attaccaatg ctttgatgga taggatgtac
    29281 tttagcaaga tgtttttagt ggtaacggta tcgtggatgg acgtgtaata acctcttctt
    29341 tcgaggagta ttttactaaa aaactagcct tggagcgttc cccagaaacg gacttactca
    29401 ttgactcttc aaagatttgg ggagaagatt ttgcttcatc tgttccttga aaaaagtcac
    29461 agcagtcatc acagacgata gtactgaaca aaactatgaa gagttagaaa tttatacgca
    29521 ggtgattgta taaaggatct ggaaatagat aagaagttga ttagtattga cctaggtggt
    29581 acaaatatta agattactgt tctttcaaat gacggtgaga ttgaaacttt gtggagtatt
    29641 acaacagata caagtgagaa aggttctcaa attatatcgg acatcatcag ttctattaaa
    29701 aataaattga ccgaacggaa tattcctgat agcgaccttc ttggaatcgg tatgggaagt
    29761 tgctcatcat actttccttg taaatcatag gggctataaa ctctccgtct acttgtcctg
    29821 caacaattga agtctgctca aaacgccgtc cgctaatctt ttcatagact ttctcccttt
    29881 taggagccta gctttctagt ttgttctttg atttttattg agtataccac tattttactc
    29941 cctctggcaa gggactttgt ctatgtggag ggattgggct cctatgtggt ggagcttttc
    30001 tgttctttct gaaatatggt ataatagcac taatcaattt ctaggaaaat agatacagaa
    30061 aggggctgaa agatgtctca tattattgaa ttgccagaga tgctggcaaa ccaaatcgcg
    30121 gctggagagg tcattgaacg tcctgccagt gtggtcaaag agttggtaga aaatgccatt
    30181 gacgcgggct ctagtcagat tatcattgag attgaggaag ctggtctcaa gaaggttcaa
    30241 atcacggata acggtcatgg aattgcccac gatgaggtgg agttggccct gcgtcgccat
    30301 gcgaccagta agataaaaaa tcaagcagat ctctttcgga ttcggacgct tggttttcgt
    30361 ggtgaagcct tgccttctat tgcgtctgtt agtgtcttga ctctgttaac ggcggtggat
    30421 ggtgctagtc a
//
LOCUS       DBMVGT010000018        29692 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.018, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000018 DBMVGT010000000
VERSION     DBMVGT010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 29692)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 29692)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..29692
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.018"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            131..385
                     /gene="blpM"
                     /locus_tag="AC0DU4_000888"
     CDS             131..385
                     /gene="blpM"
                     /locus_tag="AC0DU4_000888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379879.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit BlpM"
                     /protein_id="HIN4236874.1"
                     /translation="MDTKIMEQFHEMDITMLSSIEGGKNNWQTNVLEGGGAAFGGWGL
                     GTAICAASGVGAPFMGACGYIGAKFGVDLWAGVTGATGGF"
     gene            401..604
                     /gene="blpN"
                     /locus_tag="AC0DU4_000889"
     CDS             401..604
                     /gene="blpN"
                     /locus_tag="AC0DU4_000889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit BlpN"
                     /protein_id="HIN4236875.1"
                     /translation="MNTYCNINETMLSEVYGGNSGGAAVVAALGCAAGGVKYGRLLGP
                     WGAAIGGIGGAVVCGYLAYTATS"
     gene            848..997
                     /gene="blpO"
                     /locus_tag="AC0DU4_000890"
     CDS             848..997
                     /gene="blpO"
                     /locus_tag="AC0DU4_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818346.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpO"
                     /protein_id="HIN4236876.1"
                     /translation="MDTKMMSQFAVMDNEMLACVEGGDIDWGRKISCAAGVAYGAIDG
                     CATTV"
     gene            1033..1098
                     /locus_tag="AC0DU4_000891"
                     /pseudo
     CDS             1033..1098
                     /locus_tag="AC0DU4_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863320.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ComC/BlpC family peptide pheromone/bacteriocin"
     gene            1101..1220
                     /locus_tag="AC0DU4_000892"
     CDS             1101..1220
                     /locus_tag="AC0DU4_000892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000346296.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="HIN4236877.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKIFSKSSKKDTDSTL"
     gene            2006..2389
                     /locus_tag="AC0DU4_000893"
     CDS             2006..2389
                     /locus_tag="AC0DU4_000893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein"
                     /protein_id="HIN4236878.1"
                     /translation="MKYRLFFVIFLSSVLDILLGTFLQISIVSIGWLVLYSGLFEAGV
                     FLLANKGVAVKIKEVDIRNRFKFIFGKTLWFQILLLIFLIIKLYLGLDARLILFYGHI
                     FIVFNALMYLLSSSQVSLKKNKLSS"
     gene            2441..3130
                     /locus_tag="AC0DU4_000894"
     CDS             2441..3130
                     /locus_tag="AC0DU4_000894"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
                     /protein_id="HIN4236879.1"
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQLTLIVQNYWQFSSQIGNLF
                     WIQNILSLLFIGVMIVVLVKTGHGYLFRIPRKKWLWYSILTVLVVVLQISFNVQTAKH
                     VQSTAEGWAVLIGYSGTNFAELGIYIALFFLVPLMEELIYRGLLQHAFFKHSRFGLDL
                     LLPSILFALPHFSSLPSLLDIFVFATVGIIFAGLTRYTKSIYPSYAVHVINNIVATFP
                     FLLTFLHRVLG"
     gene            3172..3405
                     /gene="blpZ"
                     /locus_tag="AC0DU4_000895"
     CDS             3172..3405
                     /gene="blpZ"
                     /locus_tag="AC0DU4_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein BlpZ"
                     /protein_id="HIN4236880.1"
                     /translation="MYKHLFFLDSKTLDRLTPYILVLASDTIAFNVFVLTFVSAVVFN
                     FLNSMLALMAIFLGAGYVVGFWLLILNENQRAN"
     gene            3556..4167
                     /locus_tag="AC0DU4_000896"
     CDS             3556..4167
                     /locus_tag="AC0DU4_000896"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
                     /protein_id="HIN4236881.1"
                     /translation="MEFFDKFHALCFGFLVLIIVITVPYTINHGDFFQNESALIIVSL
                     LVTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGSGVQHL
                     AEVSRGISLSLILTTSVFVPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSN
                     VPSFIFYLLGGLLLGFAYKKSQNLWVSTLVHMLYKSWPLLYYL"
     gene            4328..5122
                     /gene="ccrZ"
                     /locus_tag="AC0DU4_000897"
     CDS             4328..5122
                     /gene="ccrZ"
                     /locus_tag="AC0DU4_000897"
                     /EC_number="2.7.1.15"
                     /EC_number="2.7.1.229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004747 - ribokinase activity [Evidence
                     IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_function: GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006270 - DNA replication initiation
                     [Evidence IEA];
                     GO_process: GO:0051726 - regulation of cell cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell cycle regulator CcrZ"
                     /protein_id="HIN4236882.1"
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGL
                     AREQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQ
                     LSRLGYAMETPVDLLQSWQETVPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDV
                     RHSNWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTV
                     LSKLYWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     gene            5119..5754
                     /gene="trmB"
                     /locus_tag="AC0DU4_000898"
     CDS             5119..5754
                     /gene="trmB"
                     /locus_tag="AC0DU4_000898"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001266107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008176 - tRNA
                     (guanine(46)-N7)-methyltransferase activity [Evidence
                     IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HIN4236883.1"
                     /translation="MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVE
                     VGSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEAGVSNIKLLWVDGSDLTD
                     YFEDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFE
                     YSLVSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF"
     gene            5880..6359
                     /gene="rimP"
                     /locus_tag="AC0DU4_000899"
     CDS             5880..6359
                     /gene="rimP"
                     /locus_tag="AC0DU4_000899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0042274 - ribosomal small subunit
                     biogenesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HIN4236884.1"
                     /translation="MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVD
                     KPEGITLNDTADLTEMISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGK
                     YIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVQIPYSLVSKARLAVKL"
     gene            6403..7539
                     /gene="nusA"
                     /locus_tag="AC0DU4_000900"
     CDS             6403..7539
                     /gene="nusA"
                     /locus_tag="AC0DU4_000900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_process: GO:0006353 - DNA-templated transcription
                     termination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination factor NusA"
                     /protein_id="HIN4236885.1"
                     /translation="MSKEMLEAFRILEEDKGIKKEDIIDAVVESLRSAYRRRYGQSDS
                     VAIDFNEKTGDFTVYTVREVVDEVFDSRLEISLKDALAINSAYELGDKIKFEEAPAEF
                     GRVAAQSAKQTIMEKMRKQTRAITYNTYKEHEQEIMSGTVERFDNRFIYVNLGSIEAQ
                     LSKQDQIPGEVFASHDRIEVYVYKVEDNPRGVNVFVSRSHPEMIKRLMEQEIPEVYDG
                     TVEIMSVAREAGDRTKVAVRSHNPNVDAIGTIVGRGGANIKKITSKFHPARYDAKNDR
                     MVPIEENIDVIEWVADPAEFIYNAIAPAEVDQVIFDENDSKRALVVVPDNKLSLAIGR
                     RGQNVRLAAHLTGYRIDIKSASEFEAMEDAASVELEVENDTVEE"
     gene            7561..7854
                     /gene="rnpM"
                     /locus_tag="AC0DU4_000901"
                     /gene_synonym="ylxR"
     CDS             7561..7854
                     /gene="rnpM"
                     /locus_tag="AC0DU4_000901"
                     /gene_synonym="ylxR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNase P modulator RnpM"
                     /protein_id="HIN4236886.1"
                     /translation="MKTRKIPLRKSVVSNEVIDKRDLLRIVKNKEGQVFIDPTGKANG
                     RGAYIKLDNAEALEAKKKKVFNRSFSMEVEESFYDELIAYVDHKVKRRELGLE"
     gene            7847..8146
                     /locus_tag="AC0DU4_000902"
     CDS             7847..8146
                     /locus_tag="AC0DU4_000902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxQ-related RNA-binding protein"
                     /protein_id="HIN4236887.1"
                     /translation="MNKQKISNLLGLAQRAGRIISGEELVVKAIQDGKAKLVFLAHDA
                     GPNLTKKIQDKSHYYQVEIVTVFSTLELSIAVGKSRKVLAVTDAGFTKKMRSLME"
     gene            8163..10955
                     /gene="infB"
                     /locus_tag="AC0DU4_000903"
     CDS             8163..10955
                     /gene="infB"
                     /locus_tag="AC0DU4_000903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003743 - translation initiation factor
                     activity [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006413 - translational initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HIN4236888.1"
                     /translation="MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAA
                     KIAASFKPAAAPKVEAKPAAPKVSAEKKAEKSEPAKPAVAKEEAKPAEPVAPKTEKVA
                     VKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNR
                     RFNDQAKKQQGQQKRRNERRQQEDKRSNQAAPRIDFKARAAALKAEQNAEYARSSEER
                     FKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKK
                     QARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTP
                     KPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGET
                     IELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTL
                     LDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDIT
                     ILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTA
                     WGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAV
                     ATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGD
                     HFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADV
                     QGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQAR
                     QQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIG
                     GFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDGYNDI
                     KMDDVIEAYVMEEIKR"
     gene            11206..11556
                     /gene="rbfA"
                     /locus_tag="AC0DU4_000904"
     CDS             11206..11556
                     /gene="rbfA"
                     /locus_tag="AC0DU4_000904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HIN4236889.1"
                     /translation="MANHFRTDRVGMEIKREVNEILQKKVRDPRVQGVTITDVQMLGD
                     LSVAKVYYTILSNLASDNQKAQIGLEKATGTIKRELGRNLKLYKIPDLTFVKDESIEY
                     GNKIDEMLRNLDKN"
     gene            11835..12614
                     /locus_tag="AC0DU4_000905"
     CDS             11835..12614
                     /locus_tag="AC0DU4_000905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236890.1"
                     /translation="MAEQDLAMQVLQQVVKLPVVKVDRSKFLVDKFSKELDPKDIPTL
                     LEQDPTTLLSQEILDRVANACIRDNVLLASGTSVLAGLPGGLAMAITIPADVAQFYAF
                     SLKLAQELGYIYGYEDLWASREELSEDAQNTLLLYLGVMLGVNGTAALLRAGGITIAK
                     QVMKTVPNKALTKTLWYPILKKVLKIFGVNLTKGGLAKGIGKFIPILGGIISGGLTFA
                     TMKPMGESLQKELSKLVNYSEVQYQEDVETIRKEAEIIKGE"
     gene            12616..12798
                     /locus_tag="AC0DU4_000906"
     CDS             12616..12798
                     /locus_tag="AC0DU4_000906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236891.1"
                     /translation="MNPIKAFAKIYGNYFLTVQGVKVMKTIKKADHVVVGLGKLFIAD
                     KLMDTARWLIKPEERE"
     gene            complement(13063..13215)
                     /locus_tag="AC0DU4_000907"
     CDS             complement(13063..13215)
                     /locus_tag="AC0DU4_000907"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236892.1"
                     /translation="MKIKEQTRKLAAGCSKQCFEVVDRTDEVSSKHRFEVVDRTDEVS
                     NIYTAR"
     gene            13246..13479
                     /locus_tag="AC0DU4_000908"
     CDS             13246..13479
                     /locus_tag="AC0DU4_000908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1858 domain-containing protein"
                     /protein_id="HIN4236893.1"
                     /translation="MDNIIDVSIPVAEVVDKHPEVLEILVELGFKPLANPLMRNTVGR
                     KVSLKQGSKLAGTPMDKIVRTLEANGYEVIGLD"
     gene            13479..14813
                     /locus_tag="AC0DU4_000909"
     CDS             13479..14813
                     /locus_tag="AC0DU4_000909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000752887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF438 domain-containing protein"
                     /protein_id="HIN4236894.1"
                     /translation="MTDERIHILRDILLELHNGASPESVQDRFDATFTGVSAIEISLM
                     EHELMNSDSGVTFEDVMELCDVHANLFKNAIKGVEVSDTEHPGHPVRVFKEENLALRA
                     ALIRIRRLLDTYESMEDEEMLAEMRKGLVRQMGLVGQFDIHYQRKEELFFPIMERYGH
                     DSPPKVMWGVDDQIRELFQTALTTAKSLPEVSISSVKEAFEAFATEFESMIFKEESIL
                     LMILLESFTQDDWLQIAEESDAYGYAIIRPSEKWVPERQSFIEEKIAEEPVQLDTAEG
                     QVQQVIDTPEGHFTITFTPKEKEAVLDRHSQQAFGNGYLSVEQANLILNHLPMEITFV
                     NKEDIFQYYNDNTPADEMIFKRTPSQVGRNVELCHPPKYLDKVKTIMKGLREGSKDKY
                     EMWFKSESRGKFVHITYAAVHDEDGEFQGVLEYVQDIQPYREIDTDYFRGLE"
     gene            14823..15077
                     /locus_tag="AC0DU4_000910"
     CDS             14823..15077
                     /locus_tag="AC0DU4_000910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1912 family protein"
                     /protein_id="HIN4236895.1"
                     /translation="MSYEQEFMKEFEAWVNTQIMINDMAHKESQKVYEEDQDERAKDA
                     MIRYESRLDAYQFLLGKFENFKAGKGFHDLPEGLFGERNY"
     gene            15173..15568
                     /locus_tag="AC0DU4_000911"
     CDS             15173..15568
                     /locus_tag="AC0DU4_000911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-hairpin-helix domain-containing protein"
                     /protein_id="HIN4236896.1"
                     /translation="MSKKLNRKKQLRNGLRRAGAFSSTVTKVVDETKKVVKRAEQSAS
                     AAGKAVSKKVEQAVEATKEQAQKVANSVEDFAANLGGLPLDRAKTFYDEGIKSASDFK
                     NWTEKELLALKGIGPATIKKLKENGIKFK"
     gene            15852..16430
                     /locus_tag="AC0DU4_000912"
                     /pseudo
     CDS             15852..16430
                     /locus_tag="AC0DU4_000912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813803.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase family protein"
     gene            16417..16974
                     /locus_tag="AC0DU4_000913"
     CDS             16417..16974
                     /locus_tag="AC0DU4_000913"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000124554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4236897.1"
                     /translation="MARTELPDKIETERLVLRVRTVADAEDIFDYASLPEVAYPAGFP
                     PVKTLEDEIYYLEHILPERNQKENLPAGYGIVVKGTDKIVGSVDFNHRHEDDVLEIGY
                     TLHPDYWGRGYVPEAACALIDLAFKELGLHKIELTCFGYNLQSQRVSEKLGFTLEARI
                     RDRKDVQGNRCDSLIYGLLKSEWEE"
     gene            16976..17938
                     /locus_tag="AC0DU4_000914"
     CDS             16976..17938
                     /locus_tag="AC0DU4_000914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-binding factor A"
                     /protein_id="HIN4236898.1"
                     /translation="MSDVKEEVSSLSEKQLRQIDVEYAELNDSDIIERLAYLEINNNE
                     KRIVISDIEPTKEIMSVSDQIFEIQKNFQKIKNMFELFISDVSDFLSIKNKLESKELE
                     IEEADVNRFMIHLLSSGKLFVDFNENQIKQKYSKDSEEFDCIHGFASYQYDTNFAYRF
                     CHSLRNYSQHTDLPINEVKAVSPDDETVIIDFYIDLDYLLNSNFKWKKLKGELIKLNQ
                     ETSKIDAIALVKEYFNALTELYGNYNKLFLKLNHNTLVDIKSKLESLKLKHSRYYISK
                     ISKYDLKYNPGNYTMSPLAAFAEIEEIYIELSKIGLVKIVNKSN"
     gene            17950..20601
                     /locus_tag="AC0DU4_000915"
     CDS             17950..20601
                     /locus_tag="AC0DU4_000915"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0004832 - valine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006438 - valyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HIN4236899.1"
                     /translation="MSKELSSKYNPAEVEAGRYQKWLDADVFKPSGDQKAKPYSIVIP
                     PPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLRGEG
                     ISRYDLGRESFLTKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVF
                     VNLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVAT
                     TRPETMFGDVAVAVNPEDPRYKDLIGKNVILPIANKLIPIVGDEHADPEFGTGVVKIT
                     PAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAFEFSGMDRFEARKAVVAKLEEIGALV
                     KIEKRVHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDT
                     FLQWMENVHDWVISRQLWWGHQIPAWYNADGEMYVGEEAPEGDGWTQDEDVLDTWFSS
                     ALWPFSTMGWPEVDSEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFQNVL
                     IHGLIRDEQGRKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDA
                     SWNFINKIWNISRYILMNNGGLTLDVAHDNVTKVATGEAGNVTDRWILHNLNETIGKA
                     TANFDKFEFGVAGHILYNFIWDEFADWYVELTKEVLYSDNEEDKVITRSVLLYTLDKI
                     LRLLHPIMPFVTEEIFGQISEGSIVTAAYPTVNLAFEDLAAHTGVESLKDLIRAVRNA
                     RAEVNVAPSKPITILVKTSDSDLEAFFNSNVNYIKRFTNPEHLEIASTIPAPELAMSS
                     VITGAEIYLPLADLLNVEEELDRLDKELAKWQKELDMVGKKLSNERFVANAKPEVVQK
                     ERDKQADYQAKYDATVARIDEMKKLVK"
     gene            20672..21427
                     /locus_tag="AC0DU4_000916"
     CDS             20672..21427
                     /locus_tag="AC0DU4_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3883 domain-containing protein"
                     /protein_id="HIN4236900.1"
                     /translation="MSKHPHYELLNLIGYGLAKFDKLFIKEFQCSSKSEFYRYVVSLG
                     IAETTGVVKNRMDLFDPYFDNNRKGWWQKAEVYRFRKDLIDMMFGNEDVHSYAEIVKM
                     LLASEGKKTGITIVEKPIVRTKFKRLQETGMEAENYFILHFDKEEKFQGGQLTDARLY
                     GDGYDFQVDVQEYSYLAEVKGIRKSKGRVRLTAKEFEKVKEFQSDFILSLVTNLDDIP
                     KLVLIDNPLKHFEFKKNIIKNEIIEYRSLEDLY"
     gene            21467..21610
                     /locus_tag="AC0DU4_000917"
     CDS             21467..21610
                     /locus_tag="AC0DU4_000917"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236901.1"
                     /translation="MTGQRLNELEINGIRLTKFKNGEIGIEFIWIDTENPPSDAIGWV
                     AKK"
     gene            21713..22695
                     /locus_tag="AC0DU4_000918"
                     /pseudo
     CDS             21713..22695
                     /locus_tag="AC0DU4_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397831.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TOTE conflict system archaeo-eukaryotic primase
                     domain-containing protein"
     gene            22801..24495
                     /locus_tag="AC0DU4_000919"
                     /pseudo
     CDS             22801..24495
                     /locus_tag="AC0DU4_000919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268095.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
     gene            24795..25634
                     /gene="licT"
                     /locus_tag="AC0DU4_000920"
     CDS             24795..25634
                     /gene="licT"
                     /locus_tag="AC0DU4_000920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator LicT"
                     /protein_id="HIN4236902.1"
                     /translation="MIIKRILNHNAVIAQSKKDIDILLFGRGIAFGRKTGDKVNPIDI
                     EKSFFLKNRDNMTRFTEMFINVPLELVYITEKIINLGKITLGNNFDEIIYINLTDHIS
                     SSIERYKEGIIISNPLRWEISKYYKEEFELGKRALQIIKKELGIELPIDEAAFIALHF
                     VNANLENNFQESYKITEIIMGIEKIIQDFYCTEFNQDSIDYYRFITHIKLFAHRLVEN
                     TTYCDDDDEDLLALMKNKYPREYECGEQVAMFIQTEYNYLLTSSELAYLMAHIRRLTK
                     NLD"
     gene            25652..27490
                     /locus_tag="AC0DU4_000921"
     CDS             25652..27490
                     /locus_tag="AC0DU4_000921"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_function: GO:0015573 - beta-glucoside transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0015759 - beta-glucoside transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta-glucoside-specific PTS transporter subunit
                     IIABC"
                     /protein_id="HIN4236903.1"
                     /translation="MSYKDTVQKILDVIGGEKNVNRVTHCVTRLRLELKDENLVNDDD
                     VKKIPGVIGIMKKNGQYQIILGNDVANYYKEFVKLGNFESDSVVQGHKGNILERIIEY
                     IAGSMTPIIPAMLGGGMLKVLVIILPMLGILQSDSQTIAFLTFFGDAPYYFLPLLLAY
                     SASQKLKVTSTLAMSVAGVLLHPNFVQMVQSGNPLSLFGAPVTPASYGSSVVPILIMV
                     WLMKYIEKIIAKLTLAITKSFLQPTLVLLVSSCIALVVVGPIGVIVGEGLSNLVGQMY
                     GVAGWLTLAILGAIMPFIVMTGMHWAFAPIFLAASIATPDVLILPAMLGSNLAQGAAS
                     MAVALKSKNNNTKQIAFAAGFSALLAGITEPALYGVTLKYKKPLYAAMIGGGLAGLFA
                     GLTSVKAYLFAVPSLIALPQFIYSDVPSNIVNALIVAVISVVITFVLAYIFGIDEEES
                     SSNLEVEAGVSNKKMIFSPISGEIIPLSDVQDKTFSDKLIGDGVAIIPSEGKVYAPFD
                     GKITNIFPTKHAIGLKSDEGVELLIHIGLDTVELKGQGFISHVEEGDRVFKNQLIFEM
                     DLNLIKTKGYETVTPVIVTNTNDFLDVLVLPNNQTIEHSKELLVIL"
     gene            27503..28918
                     /locus_tag="AC0DU4_000922"
     CDS             27503..28918
                     /locus_tag="AC0DU4_000922"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HIN4236904.1"
                     /translation="MTIFPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEA
                     TENPTEDNLKLIGIDFYHKYKEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGL
                     KYYDELFDELHAHGIEPLVTLSHYETPLYLARKYHGWVDRRMIHFYEKFARTVLERYK
                     DKVKYWLTFNEVNSVLELPFTSGGIDIPKENLSKQELYQAIHHELVASSLVTKIAREI
                     NSEFKVGCMVLAMPAYPMTPNPKDVWVTHEYENLNYLFSDVHVRGYYPNYAKRYFKEN
                     DINIEFAAEDAELLKNYTVDFLSFSYYMSVTQSALPTQYNSGEGNIIGGLVNPYLESS
                     EWGWQIDPIGLRIILNRYYDRYQIPLFIVENGLGAKDQLIKDELNNLTVQDDYRIQYM
                     KEHLLQVAEALQDGVEIMGYTSWGCIDCVSMSTAQLSKRYGLIYVDRNDDGSGTLNRY
                     KKMSFTWYKEVIESNGESLFK"
     gene            29400..>29692
                     /locus_tag="AC0DU4_000923"
     CDS             29400..>29692
                     /locus_tag="AC0DU4_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HIN4236905.1"
                     /translation="MSTIEEQLKALREETLASLKQITAGNEKEMQDLRVSVLGKKGSL
                     TEILKGMKDVSAEMRPIIGKHVNEARDVLTAAFEETAKLLEEKKVAAQLASES"
BASE COUNT         9244 a         4969 c         6579 g         8900 t
ORIGIN      
        1 taatttttgc aattcaagac gtttcgatga ctattcaaga tctggatgaa aaattttaaa
       61 aaacgatgat atactaaact tgtcaaagtt acaacaagac aaaaattaaa aataaaaaag
      121 agtatttgtc atggatacaa aaattatgga acaatttcat gaaatggata taactatgtt
      181 atctagtatt gaaggaggca agaataattg gcaaactaat gtcttagaag gtggtggtgc
      241 tgcttttggt ggctgggggc tagggacagc tatttgtgct gcgagtggtg ttggagcacc
      301 atttatggga gcatgtggat acataggagc taaatttggt gtggatcttt gggcaggagt
      361 aacaggggca acgggtggat tttaataaaa ggagacttgt atgaatactt attgtaatat
      421 aaatgaaaca atgctgagtg aggtttatgg aggtaattcc ggaggagcag ctgtagttgc
      481 tgctttaggt tgtgcagcgg gtggagtgaa atatgggaga cttctaggac catggggcgc
      541 tgcaatagga ggaattggag gagcagtggt ttgtggatat ttagcctata ccgctacatc
      601 ataaaaatga aagctaaatt ttatgaaggc tatattcttt attattctct tcgcttttca
      661 aacctatctt atttatctat ccataagtat ctccgataaa aaacaaaaga ctattgaatt
      721 aacatcattg aattgttttg tcatattatt tctaatctat gataaattaa tttttctctt
      781 tattgcctat gtttttttga taatttttat attaaacttg ttccgtaact gaaaagtgat
      841 atactatatg gatacaaaaa tgatgtcaca atttgcagtt atggataatg aaatgcttgc
      901 ttgcgttgaa ggtggagata ttgattgggg aagaaaaatt agttgtgcag caggggttgc
      961 atatggcgca attgatgggt gtgcaacaac ggtttgacat ttctattggg accatttgct
     1021 ataggaatag gtgtaactgg tgctgcggga ggagctatac ttggaggtgt ggcctatgca
     1081 gcgacatgtt ggtggtaatt atggatttta aaagttttat tattggttta gtagttggta
     1141 tatttggtcc ttatatggat gacttaatta gaaaaatatt ttcaaaatct tccaaaaagg
     1201 atacggatag tactctctaa aaaataaatt tctcccctgt atttgctagc ttaatttaca
     1261 ggggagtttc tttaatattg tttcgcctgt caaaatgata tgtgatagca ggatgaaaag
     1321 tctacaaaca agttggtatc aatacaatat aaagaggaaa gtatgttttt aatgcttact
     1381 ttttaaattt tttaacaatt caagatgttt cgatgacaat tcaagatttg gatgaaaaat
     1441 tttaaaaaac aatgatatac taaacttgtc aaagttgcaa cgggtgctgc tacattatgt
     1501 taaaaatcgc tcttgattga taagttggat ttgttaggaa aggagtaaat aattatggat
     1561 aagaaaaaga tagtttcgac tataatatgt atagtatttc ttgtagtgtc agtagataat
     1621 ttttttagag acttaacccc gttactgttc attttaaata ttattggcct gtcttgcttt
     1681 tcagtgctaa catacattaa cataaaagag atactcttaa atataagtaa atgatgattt
     1741 ggttagtcct agaaccaatc aacttatgtt tatcggcttg gcagatttta tgtttgtcat
     1801 ttgtttgtat agaggtattt cagaaacaga attctatcaa caactaatcg cttatatagg
     1861 tgtattctct gcttgtttat cacgcttctg ctcatgtggg gcttgaagta ttataaaaag
     1921 tagctttcta tccttttctg acaggatatt tgagtagaag gctctattaa attgttagtg
     1981 aaataaatga atggaggtat ttaatatgaa atacagatta ttttttgtta ttttcttgag
     2041 tagtgtgttg gatattcttt tagggacatt tttacaaatc tctatcgtat ctattgggtg
     2101 gcttgttctt tacagtggtt tgtttgaagc aggagttttc cttcttgcta ataaaggggt
     2161 ggcggtaaaa atcaaggaag tagatattcg aaatcgcttt aaatttattt ttggaaaaac
     2221 cttatggttt caaattcttt tgctcatctt tttgataatc aaactttatc ttggtttgga
     2281 tgcgaggttg attttattct atggacatat tttcattgtc tttaatgcct taatgtatct
     2341 attatctagt agtcaggtta gccttaaaaa aaacaaactg tcttcttaat cttacagcag
     2401 tagagcctga caaggtgagg tcatagtagg gaggatttct atgaaaaagt atcaacttct
     2461 attcaaaata agtgcagtct tctcttactt atttttcgta tttggtcttt ctcagctgac
     2521 gcttatcgtc caaaactatt ggcaattttc ttctcagata ggcaatttat tctggattca
     2581 aaatatcttg agtttacttt ttattggagt catgattgtg gttcttgtta agacaggcca
     2641 tggttatctc ttccgcattc caagaaaaaa atggctttgg tattcgattt tgacagtatt
     2701 agtggtagtg ttacagatct cttttaacgt tcagacagct aaacatgttc agtcaactgc
     2761 ggaaggttgg gctgtattga ttggttatag tgggactaac tttgcagagc taggtattta
     2821 tatagccctg ttctttctgg ttccactgat ggaagaattg atttatagag gattactgca
     2881 acatgctttc tttaagcatt cgcgatttgg tcttgatttg cttcttcctt ctattttatt
     2941 tgctctccct catttttcaa gcctgcctag tctgttagat atcttcgtct ttgcaacagt
     3001 tggaatcatc tttgctggtt tgacccgcta taccaagagc atttatccat cctatgcggt
     3061 gcatgtgatc aataatattg tagcgacctt cccgtttttg ctcacttttc tacatagggt
     3121 cttggggtaa aaaaacaaaa ggcttgcttt tcagccatag aggaggtcat catgtataaa
     3181 cacttatttt tcctagattc caaaacttta gatcggttga caccctatat tctagtcttg
     3241 gcttctgaca ccattgcttt taatgttttt gtgctaacct ttgtatctgc ggtggttttt
     3301 aatttcctaa attccatgct agctttaatg gctatcttct taggagctgg ctatgtggtc
     3361 ggattttggt tactaatact caatgaaaat caaagagcaa actaggaaac tagccgcagg
     3421 ctgtacttga gtacggcaag gcgacgttga cgtggtttga atttgatttt cgaagagtat
     3481 aaaatggttt gttttggaaa ggctagaact aaaggatgac gtgtaggaag tctgtttgtt
     3541 gaggaggata attttatgga gttttttgat aaatttcatg ccttgtgttt tggattttta
     3601 gtactaataa ttgtcattac agttccttat acgattaacc atggggattt ttttcaaaat
     3661 gaatctgcat tgattattgt aagtcttctt gtaacctcgc tgagtgttgc ttatgctaga
     3721 aagtttgaaa tgatttcttt tgggatgtta agcaagaaac aacttttgct tttcattgca
     3781 atctttcttc taagtgtgct tgagacgctg gtttatattc atttcttcgc tgtttcttct
     3841 ggctcagggg tccaacactt ggcggaagtc agcagaggaa tttccctgtc tttgattttg
     3901 actacctcag tttttgtccc catccaggag gaactcattt tcagaggact tcttcaaggt
     3961 gcggtttttg acaattcttg gttagggctt gtgctaactt cctctctctt ttctttcatg
     4021 catggacctt ctaatgtccc ttcgtttatt ttttatctac ttgggggctt gttactgggc
     4081 tttgcttata aaaagagtca aaacctatgg gtttctactc tagtacatat gctttacaaa
     4141 agttggccac tcttatatta tttataaaaa ttatgaaaag gtaagcagaa gacggtgctt
     4201 acctttttca agctataatg atacccaagc caatccagag gcttttcttt gagaatcggg
     4261 ttagagtggt tgacgaatag gccaaaaact agtagaatag taaggaaact ttatacggag
     4321 gaaagaaatg gatttgggtg ataatgagct aacactgact cccatacctg ggaaaagtgg
     4381 caaggcttat atgggtagct atcctgatgg gaagcgcatc tttgtaaaaa tgaacacctc
     4441 tccaatccta cctggtctag ctagagaaca aattgctcca caattattat ggagtcgtcg
     4501 tttggcagat gggcgtgata tgtgtgctca agaatggttg acaggcaaga tattgacccc
     4561 ctatgatatg aatcgtaagc aaatcgtcaa tattttaacc cgtcttcatc gctcacgtcc
     4621 gttgatgaca caattgagtc gtttgggcta tgccatggaa acacctgtag atttactaca
     4681 gtcttggcag gaaacggttc cagatgcttt gcgtaaaaat cattttatca gtgaagtgat
     4741 ggctgattta cgtcagacta ttccaggatt tagagaggac catgcgacca ttgtccatgg
     4801 agatgtacga catagtaatt ggattgagac agatagtggc ttgatttatt tagtagattg
     4861 ggattcggtt cgcttgaccg atcgcatgtt tgatgtggcc catatgctct gccattatat
     4921 ttcggaacat cagtggaagg aatggttgac ctactacggt tacaagtaca atcaaacggt
     4981 attaagtaaa ttgtattggt atggtcaatt gtcttatttg agtcagattt ccaagtatta
     5041 tatgaaccaa gatttagaaa atgtcaatcg ggagattcat ggtttgcgtc atttccgaga
     5101 caagtatgga aagagaagat gagagttaga aatcgtaaag gggcaacaga attactagag
     5161 gcaaatcccc agtatgtggt cctcaatccc ttggaagcca aggcaaaatg gcgggacttg
     5221 tttggcaatg ataatcccat tcatgtggaa gttggaagtg gaaagggtgc ctttgtttca
     5281 ggtatggcca agcaaaaccc tgacatcaac tatatcggga ttgatattca aaagtctgtt
     5341 ttgagctacg ctttggacaa ggtgcttgaa gctggagtgt ctaacatcaa gctcttgtgg
     5401 gtagatggtt ctgacttgac tgactacttt gaagacggtg agattgatcg cttgtatctg
     5461 aacttttcag atccatggcc gaaaaaacgc catgaaaagc gtcgtttgac ctacaagacc
     5521 tttttggata ccttcaaacg tatcttgcct gaaaatggag aaattcattt caagacggat
     5581 aaccgtggct tgtttgagta cagtttagtg agcttttctc aatatggcat gaaactcaat
     5641 ggtgtctggc tagatttgca tgccagtgat tttgaaggca atgtcatgac agaatacgag
     5701 caaaaattct caaacaaggg gcaagttatc taccgagttg aggcagaatt ttaagagata
     5761 gcctaaaatt aggctgtaca agtgcttttg ctttacataa gttggcaaac gtgctatact
     5821 gatagtaaga atatgaaaag tgaggcgggg aaatatcttc gcctcttgct tatgaggagg
     5881 tggacgcaat cgcaacaatc gtagaattag tcagagaagt tgtagaacct gtcatagaag
     5941 ctccttttga actcgtggat atcgagtatg gaaagattgg cagtgacatg attctcagta
     6001 tttttgtaga taaacccgaa ggaattacct tgaacgacac ggcagacttg acagaaatga
     6061 tcagtcctgt cctagacacc atcaagccag atcccttccc agaacaatat ttcctagaaa
     6121 ttaccagtcc aggtttggaa cgtcctttga aaaccaagga tgccgtagct ggagcggttg
     6181 gaaaatacat ccatgtcggg ctctaccaag ccatcgataa gcaaaaggtc tttgaaggaa
     6241 ctttgttggc cttcgaagag gacgagttga ctatggaata tatggacaag acgcgtaaga
     6301 aaaccgtcca aattccatac agtttagtat caaaagcacg tttagcagtt aaattataga
     6361 aaaagaaagg atagcttttg aggattcaaa agtgaagaaa acatgagtaa agaaatgcta
     6421 gaggccttcc gcattttgga agaagacaag ggaatcaaaa aagaagatat catcgacgca
     6481 gtagtagagt cgcttcgttc cgcttatcgc agacgctatg gtcagtcaga cagcgtagct
     6541 attgacttca acgaaaaaac aggtgacttt acagtttata ctgtccgtga agttgttgat
     6601 gaagtatttg atagccgttt ggaaatcagc ttgaaagatg ctcttgccat taattcagct
     6661 tatgaacttg gagacaaaat caagtttgaa gaagcaccag ctgagtttgg tcgtgtagca
     6721 gcccaatctg ccaaacaaac catcatggaa aaaatgcgca agcaaacacg tgccatcact
     6781 tacaatactt acaaagaaca tgagcaagaa atcatgtctg gtacagtaga acgctttgac
     6841 aaccgcttta tctatgtcaa ccttggtagt atcgaagccc aattgtcaaa acaagaccaa
     6901 attcctggag aagtttttgc ttctcatgat cgtatcgaag tttatgttta caaggttgaa
     6961 gacaaccctc gtggtgtgaa cgtctttgtt agccgtagcc atccagaaat gatcaaacgt
     7021 ttgatggagc aagaaattcc agaagtttat gatggaactg ttgaaatcat gagcgtggct
     7081 cgtgaagcag gtgaccgtac gaaggttgct gttcgtagcc acaatccaaa cgtggatgct
     7141 atcggtacaa tcgttggacg tggtggtgct aatatcaaga agattactag caaattccac
     7201 ccagctcgtt acgatgctaa aaatgaccgc atggtaccaa tcgaagaaaa tatcgatgtt
     7261 atcgagtggg tagcagatcc agctgaattt atctacaatg ccatcgctcc tgctgaggtt
     7321 gaccaagtta tctttgatga aaacgacagc aaacgtgcct tggtggttgt tccagataac
     7381 aagctttctc ttgccattgg tcgtcgtgga caaaacgtgc gcttggcggc tcacttgact
     7441 ggttaccgta tcgatatcaa gtctgctagc gaatttgaag ccatggaaga cgctgcttca
     7501 gtagagttgg aagtagaaaa cgatactgta gaagaataaa agctgctaga ggagggaaag
     7561 atgaaaacaa gaaaaatccc tttgcgcaag tctgttgtgt ctaacgaagt gattgataag
     7621 cgtgatttgc tccgcattgt caagaacaag gaaggacaag tctttattga tcctacgggc
     7681 aaggccaatg gccgcggcgc ttatatcaaa ctagacaatg cagaagccct agaggcgaaa
     7741 aagaagaagg tctttaaccg cagctttagc atggaagtgg aagaaagctt ttatgacgag
     7801 ttgatcgctt atgtggatca caaagtgaaa agaagagagt tgggacttga ataagcaaaa
     7861 gataagtaat ctcttggggc ttgctcagcg agcagggcgc atcatatcgg gtgaagaatt
     7921 ggtggtcaag gccattcaag acggcaaggc caagttggtc tttctagctc atgatgctgg
     7981 acccaatctg accaagaaga ttcaagataa aagtcattat tatcaagtag aaattgtaac
     8041 cgtgttttca acactggaat taagcatagc agtcgggaaa tcgagaaagg ttttggctgt
     8101 aacagatgct ggatttacaa agaaaatgag gtctcttatg gaatagaaga ggaggacatg
     8161 atttgtctaa gaaaagattg tacgaaatcg caaaagaact tggaaaagaa agtaaagaag
     8221 ttgtagcgcg tgcaaaagag ttaggcttgg atgtgaaaag ccactcatca agtgtggaag
     8281 aagctgtcgc tgcaaaaatt gctgccagct ttaagcctgc agctgctccg aaagtagaag
     8341 caaaacctgc agcaccaaaa gtaagtgcag aaaagaaagc cgaaaaatct gagccagcta
     8401 aaccagctgt agctaaggaa gaggcaaaac cggctgagcc agttgctccg aaaacagaaa
     8461 aagtagcagt gaaaccgcaa agtcgtaatt tcaaggctga gcgtgaagcc cgtgctaaag
     8521 agcaggcaga acgacgcaag caaaataagg gcaataaccg tgaccaacaa caaaacggaa
     8581 accgtcagaa aaacgacggc cgtaatggtg gaaaacaagg tcaaagcaac cgcgacaatc
     8641 gtcgctttaa tgaccaagct aagaagcagc aaggtcagca aaaacgtaga aatgagcgcc
     8701 gtcagcaaga ggataaacgt tcaaatcaag cggctccacg tattgacttt aaagcccgtg
     8761 cagcagccct aaaagcagag caaaatgcag agtacgctcg ttcaagtgag gaacgcttca
     8821 agcagtatca ggctgctaaa gaagccttgg ctcaagctaa caaacgcaag gaaccagagg
     8881 aaatctttga agaagcggct aagttagctg aacaagcaca gcaagttcaa gcagtggttg
     8941 aagtcgtccc tgagaaaaaa gaacctgcag tggatacacg tcgtaaaaaa caagctcgac
     9001 cagacaaaaa tcgtgacgat tatgatcatg aagaagatgg tcctagaaaa caacaaaaga
     9061 atcgaagtag tcaaaatcaa gtgagaaatc aaaagaatag taactggaat aacaacaaaa
     9121 agaacaaaaa aggcaataac aagaacaacc gtaatcagac tccaaaacct gttacggagc
     9181 gtaaattcca tgaattgcca acagaatttg aatatacaga tggtatgacc gttgcggaaa
     9241 tcgcaaaacg tatcaaacgt gaaccagctg aaatcgttaa gaaacttttc atgatgggtg
     9301 tcatggccac acaaaaccaa tccttggatg gggaaacaat tgaactcctc atggtggatt
     9361 acggtatcga agccaaacaa aaggttgaag tggataatgc tgacatcgaa cgtttctttg
     9421 tcgaagatgg ttatctcaat gaagatgaat tggttgagcg tccaccagtt gttactatca
     9481 tgggacacgt tgaccacggt aaaacaaccc ttttggatac tcttcgtaac tcacgtgttg
     9541 cgacaggtga agcaggtggt attactcagc atatcggtgc ctaccaaatc gtggaaaatg
     9601 gtaagaagat taccttcctt gatacaccag gacacgcggc ctttacatca atgcgtgcgc
     9661 gtggtgcttc tgttaccgat attacgatct tggtcgtagc ggcagatgac ggggttatgc
     9721 ctcagactat tgaagccatc aaccactcaa aagcagctaa cgttccaatc atcgtagcta
     9781 ttaacaagat tgataaacca ggtgctaacc cagaacgcgt tatcggtgaa ttggcagagc
     9841 atggtgtgat gtcaaccgct tggggtggag attctgaatt tgttgaaatc tcggctaaat
     9901 tcaaccaaaa tatcgaagaa ttgttggaaa cagtccttct tgtggctgaa atccaagaac
     9961 tcaaagcaga cccaacagtt cgtgcgatcg gtacggttat cgaagcgcgc ttggataaag
    10021 gaaaaggtgc ggtcgcaacc cttcttgtac aacaaggtac cttgaatgtt caagacccaa
    10081 tcgttgtcgg aaataccttc ggtcgtgtcc gtgctatgac caacgacctt ggtcgtcgtg
    10141 ttaaagttgc tggaccatca acaccagtct ctatcacagg tttgaacgaa gcaccgatgg
    10201 cgggtgacca ctttgccgtt tacgaggatg aaaaatctgc gcgtgcagca ggtgaagagc
    10261 gtgccaaacg tgccctcatg aaacaacgtc aagctaccca acgtgttagc cttgaaaacc
    10321 tctttgatac ccttaaagct ggggaactca aatctgttaa tgttatcatc aaggccgatg
    10381 tacaaggttc tgttgaagcc ctttctgcct cacttcaaaa gattgacgtg gaaggtgtca
    10441 aagtgactat cgtccactca gcggtcggtg ctatcaacga atcagatgtg acccttgccg
    10501 aagcttcaaa tgcctttatc gttggtttca acgtacgccc tacaccacaa gctcgtcaac
    10561 aagcagaagc tgacgatgtg gaaatccgtc ttcacagcat tatctacaag gttatcgaag
    10621 agatggaaga agctatgaaa gggatgcttg atccagaatt tgaagaaaaa gttattggtg
    10681 aagcggttat ccgtgaaacc ttcaaggtgt ctaaagtggg aactatcggt ggatttatgg
    10741 ttatcaacgg taaggttgcc cgtgactcta aagtccgtgt tatccgtgat ggtgtcgtta
    10801 tctatgatgg tgaactcgca agcttgaaac actataaaga cgacgttaag gaagttacaa
    10861 acggccgtga aggtggattg atgatcgacg gctacaatga tattaagatg gatgatgtga
    10921 ttgaggcgta tgtcatggaa gaaatcaaga gataagattt tttgctcctt tcttaggtgg
    10981 tgagggacgc aagcaaaccg atggtttcat tgcttatttt tgagcctagg gtctcaaaaa
    11041 taccctgtga tgggactgat aaatcagttc catcactttc accacggcga aagaagcaga
    11101 tgacttcaaa ttgaacttcg tttcaattta aactgaaaat caagaagttt aaaatagcta
    11161 ggtctgctgg cctagctttt ggttcaaagt agagaaagga atatcatggc aaatcatttc
    11221 cgtacagatc gtgtgggcat ggaaatcaag cgtgaagtca atgagatttt gcaaaagaaa
    11281 gtccgtgatc cacgtgtcca aggtgtgacc atcacagatg ttcagatgct gggtgacttg
    11341 tctgttgcca aggtttatta caccattttg agtaaccttg cttcggataa ccaaaaagcc
    11401 caaatcgggc ttgaaaaagc aactggtacc atcaaacgtg aacttggtcg caatttgaaa
    11461 ttgtacaaaa tcccagattt gaccttcgtc aaagacgagt ccatcgagta tggaaacaag
    11521 attgacgaga tgctacgcaa tctggataag aactaaagaa gaggggttgc ccctcttttt
    11581 tggtggagga aaataggttg aatttgaaat ggaaaaatat tcttttataa tagattgaaa
    11641 ctagaatagt acgcctctac ttctaaaaca ttgttagaaa tcgatttgac tttcctgatc
    11701 gatttgtcct gttcttgttt cattttacta taaaaaaggg gttctgtatt ttttaatgtt
    11761 atctaattag aaaatgcttt ttttgtagga aatataatat gataaggtgc aaaaaagaaa
    11821 taaggagttt gtatatggct gaacaagact tagctatgca agtattgcaa caagtggtga
    11881 aactacctgt tgttaaggtt gatcgttcga aatttttagt ggataagttt tccaaagaat
    11941 tggatccaaa agatattcct accttattgg aacaagaccc aacgactctt ctatctcaag
    12001 aaatattaga tcgtgtagct aatgcttgta ttcgggacaa tgtattatta gcgagtggga
    12061 cttctgtttt ggcaggatta cctggagggc ttgctatggc aattaccatt ccagctgatg
    12121 tggctcaatt ttatgctttc tctctgaaat tggctcaaga attaggttat atttatggtt
    12181 atgaggatct ttgggcttca cgcgaggagt tgagtgaaga tgctcaaaat accctcttgc
    12241 tttatctagg cgtaatgtta ggggtgaatg gaaccgctgc tttgctacgt gctggtggta
    12301 taacaattgc caaacaggta atgaaaacag tgcctaataa agctttaaca aagacgcttt
    12361 ggtaccctat tttgaaaaaa gtcttaaaaa tatttggtgt gaatcttacc aagggagggc
    12421 tggccaaagg aatagggaaa tttattccta tcttgggtgg tatcatttca ggtggtttaa
    12481 cctttgcaac tatgaaacca atgggggaaa gcttgcagaa agaattatcc aagctagtca
    12541 actatagtga agttcaatat caagaagatg ttgaaacaat ccgaaaagag gctgaaatca
    12601 tcaaaggaga gtaatatgaa tcctatcaaa gcttttgcta aaatttatgg taattacttt
    12661 ttgaccgtgc aaggtgtaaa agtgatgaaa acgataaaga aagctgacca tgtcgttgtt
    12721 ggtctgggca aactttttat tgcagataag ctaatggata cggctcggtg gctcattaag
    12781 ccagaggaga gagaatgaaa tttttttggt cttcttgcta ttctttttat caaaccgatt
    12841 attgggattg tgaaattctt ttggatgatc atttcttttg cagttcaatt gctgttttac
    12901 aagatattgg attggttctt taaacttatc tagatggtaa tccaagttgc agagaactag
    12961 caggaactcc actgctagtt ttttattctc tttccatatg gtataatata agcagtaaaa
    13021 tcattttata ctcttcgaaa atctcttcaa accacgtcag cttcaccttg cagtatatat
    13081 gttactgact tcgtcagttc tatccacaac ctcaaaacgg tgttttgagc tgacttcgtc
    13141 agttctatct acaacctcaa aacactgttt tgagcaacct gcggctagct tcctagtttg
    13201 ctctttgatt ttcattgagt attagaacat acaatggagg tcgtcatgga caatatcatc
    13261 gatgtgtcaa ttcctgttgc agaagtggtg gacaagcatc cagaagtctt ggaaattcta
    13321 gtggagttgg gttttaaacc ccttgccaat cccttaatgc gcaatacagt tggtcgtaaa
    13381 gtatcactta aacagggttc taagctagca ggaactccta tggacaagat tgtacgcaca
    13441 ctggaagcga atggctacga agtgattgga ttagactaat gacagatgaa cggattcata
    13501 tcctacggga tattttgtta gaattgcaca atggcgcctc tcctgagtcg gttcaagatc
    13561 gctttgatgc gacctttacg ggcgtgtcag ccatcgagat ttcccttatg gagcacgagc
    13621 tgatgaactc ggattcgggc gtcacttttg aagatgttat ggaactctgt gatgtccatg
    13681 ccaatctttt taaaaatgct atcaaaggtg tcgaagtttc agatactgag catccaggtc
    13741 acccagttcg tgtcttcaaa gaagaaaatc tggctctccg tgcggccttg attcgcattc
    13801 gtagattgtt agatacctat gagtctatgg aagacgagga aatgctggcg gagatgcgta
    13861 agggtttggt gcgtcagatg ggacttgtgg gtcaatttga catccattac caacgtaagg
    13921 aagaactctt ctttcctatc atggagcgct atggacacga ttcacctccc aaagttatgt
    13981 ggggagtgga tgatcagatt agggaactct ttcaaacagc tctaacgaca gccaagtcac
    14041 taccagaagt gtcaattagc agtgtaaagg aagcttttga agcttttgcg acagagtttg
    14101 aaagtatgat tttcaaggaa gagtccatcc tcctcatgat tctccttgag tcttttactc
    14161 aggatgactg gcttcagatt gcggaggaga gcgatgccta tggctatgcc atcatccgtc
    14221 cgtcagagaa atgggtgcca gaacgacaga gctttattga ggaaaagatt gcagaggagc
    14281 ctgtacagct agatacggca gaaggtcaag ttcaacaagt catagatacg ccagaaggcc
    14341 attttaccat tacctttacc cctaaggaaa aggaagctgt gctggaccgc catagtcaac
    14401 aggcttttgg taatggctat ctttcagtcg agcaggccaa tctcatcctc aatcatctcc
    14461 ctatggagat tacctttgtc aataaagaag atattttcca gtattacaat gacaatacgc
    14521 cagctgatga gatgattttc aaacggacgc cgtcccaagt cgggcgcaat gtcgaactct
    14581 gccatccgcc taagtacttg gacaaggtca aaactatcat gaaggggctt cgtgagggaa
    14641 gcaaagacaa gtatgaaatg tggttcaagt ctgagtcgcg aggtaagttt gtccacatca
    14701 cctatgctgc agtacacgat gaagacggag aattccaagg agtgttggag tatgttcagg
    14761 atatccagcc ctaccgtgag attgatacgg actattttcg tggattagaa taaggagaaa
    14821 aaatgagtta cgaacaagaa tttatgaagg aatttgaagc ttgggtcaat acccaaatca
    14881 tgattaacga tatggcgcac aaggaaagtc aaaaagttta cgaagaagac caggacgagc
    14941 gtgccaaaga tgccatgatt cgctacgaga gtcgcttgga tgcttatcag ttcttgcttg
    15001 gtaagtttga aaacttcaaa gcaggcaagg gattccatga tttgccagaa ggcttgtttg
    15061 gtgagcgaaa ttattaaacg agaaagattc ttgatttttc actaaaatct tgatagaatg
    15121 tttatgttaa atccttgtca gagcagggat tttttattga aaggatttta tcatgtcaaa
    15181 gaaactcaat cgtaaaaaac aattacgaaa tggcctccgt cgcgcaggtg ccttttcaag
    15241 tactgtgact aaggttgtag atgagacaaa aaaagtcgtg aagcgtgcag aacagtcagc
    15301 aagcgcagct ggtaaggctg tttctaaaaa agttgaacaa gcagtagaag ctaccaaaga
    15361 gcaagctcaa aaagtagcta attctgtaga agattttgca gcaaatttgg gtggacttcc
    15421 acttgatcgt gccaagactt tctatgatga aggaatcaag tctgcttcag atttcaaaaa
    15481 ctggactgaa aaagaactcc ttgccttgaa aggaatcggc ccagctacca tcaagaaatt
    15541 gaaagaaaat ggcatcaagt tcaagtaatt tttcttgagc cttgcatttc cgaaaaaatc
    15601 ttgctacaat agagccatta gaggtgtttt gaatcccaca ttttacagaa agtggcggcg
    15661 ctgagaagtc cacaaatgtg tcaaaactgg ttgctaatgg atgaaaaatt gaaataaaag
    15721 tgtctttttg ctttaaagac gagagttgcg ggcaactgcc cgaaattggg tggtaccgcg
    15781 gataaacaca ttcgtccctg tcatgtagat ggcagggctt ttcttttacg tcttagtcaa
    15841 agggggttgt tatgaagcaa tcttttaaca caagtaaact atattatggt tttcctgttt
    15901 ttattttagg atatcaagat tagaattttg gctataacat cacgacctgt agttcctctt
    15961 atagtctagg agattgggtt gtgattggag tcgttgcaag agagaatgcc gcagagcaga
    16021 tcaaacagta tcaaaaattt actgtgaata tttctgatga aacttctatg cttgcgatgg
    16081 agcaggctgg ttttatcagt catcaggaga aattggaacg tttgggagtg cattatgaaa
    16141 tttctgaatg aactcagact cctattttag acgcctgtcc acttgtttta gattgtcggg
    16201 tagataggat tgttgaggaa gacggtattt gccacatctt tgccaagatt cttgagcgac
    16261 ttgttgttcc agaactcctg gatgaaaagg gacattttaa aaatcaactg tttgccccaa
    16321 cctatttcat gggagatgga tatcagcgcg tttatcgcta tctggacaag cgtgtagata
    16381 tgaagggcag tttcatcaaa aaagcgagga agaaggatgg caagaactga gctgccagat
    16441 aaaatcgaaa cagaacgtct cgttttacga gtccgtactg tggcggatgc tgaggatatc
    16501 tttgactatg ctagtttgcc agaggttgcc tatccagcag gttttcctcc agtcaagacc
    16561 ttggaagatg agatttatta tctggagcac attcttccgg agcgtaatca aaaggaaaat
    16621 ctcccagcag gctacgggat tgtcgtcaaa ggaacggata agatcgttgg ctctgtcgat
    16681 ttcaaccatc gccatgaaga tgatgtgctg gaaatcggct ataccttaca cccagactat
    16741 tgggggcgag gttatgttcc agaagcagcg tgtgccttga ttgatctagc ttttaaagaa
    16801 cttggtcttc acaagattga actaacttgc tttggatata accttcaaag tcaacgagtc
    16861 tcggaaaagc ttggctttac cctcgaagct cgcataagag accgaaagga tgttcaagga
    16921 aaccgctgtg acagtctgat atatggcttg ctgaagagcg agtgggagga ataagatgag
    16981 cgatgtaaaa gaggaagtaa gctctctatc tgagaagcag ttacgccaaa ttgatgttga
    17041 gtatgctgaa ttaaatgata gtgatattat cgagcgatta gcttatttag aaattaacaa
    17101 caatgaaaaa cgtattgtca tctctgatat tgaaccaacc aaggaaataa tgtcagtatc
    17161 ggaccaaatt tttgagattc aaaagaattt tcaaaaaatc aagaatatgt tcgaattgtt
    17221 tatttcagat gtctcggatt ttttaagtat taaaaataaa cttgagtcaa aggaattaga
    17281 aattgaagag gcagatgtaa atcgtttcat gattcattta ttatccagtg gaaaattgtt
    17341 tgtcgatttt aacgaaaacc aaattaaaca aaaatattcc aaagatagtg aggagtttga
    17401 ttgtatacat ggttttgcaa gctatcagta tgataccaat tttgcttatc gattttgcca
    17461 ttctttgaga aattattcgc aacatactga cttaccaata aatgaggtaa aagctgttag
    17521 cccagatgat gagactgtta taatagattt ctatattgat ttagattatc ttttaaattc
    17581 caactttaaa tggaaaaaat tgaaagggga gttgataaaa ctaaaccaag aaacatctaa
    17641 gattgacgct atagctctag tgaaagaata ctttaatgct cttacagagc tctatggtaa
    17701 ttataataag ttgtttttaa agttaaacca taatacatta gtagatatta aatcaaagtt
    17761 ggaatcatta aaattgaaac actctaggta ttatatttca aagataagca agtatgatct
    17821 taaatataat cctggaaatt atactatgtc accacttgca gcatttgctg aaattgaaga
    17881 gatttatatt gaactttcaa aaattggttt ggttaaaatt gtcaataaaa gtaattaagg
    17941 agaacacaca tgtctaaaga actttcatct aaatacaatc cagccgaggt tgaggctggt
    18001 cgttaccaaa aatggcttga tgccgatgtt ttcaagcctt caggcgatca aaaggctaag
    18061 ccttattcaa tcgttattcc accaccaaac gttacaggta aacttcacct tggtcacgct
    18121 tgggatacaa ctttgcaaga tattatcatc cgtcaaaaac gcatgcaagg ttttgatacc
    18181 ctttggcttc ctgggatgga ccacgcaggg attgccactc aggctaaggt tgaggagcgc
    18241 ttgcgtggtg agggcatttc ccgctatgac cttggtcgtg agtctttctt gacgaaagtc
    18301 tgggaatgga aagacgaata tgccactacc atcaaggaac aatggggcaa gatggggctc
    18361 tctgtagact attctcgtga gcgtttcact cttgacgaag gtttgtcaaa agctgttcgt
    18421 aaggtctttg tgaaccttta caagaaaggc tggatctacc gtggtgagtt tatcatcaac
    18481 tgggacccag cagctcgcac agccctttct gatattgagg tgattcacaa ggatgtggaa
    18541 ggtgccttct accacatgaa ttacatgctg gaagatggtt cacgcgccct tgaagttgct
    18601 acaactcgtc ctgagactat gtttggggac gttgcggttg cggttaatcc agaagacccg
    18661 cgctacaagg acttgattgg taaaaacgtc atccttccaa tcgctaataa actcatccca
    18721 atcgttggag atgagcacgc agatcctgag tttggtactg gtgtcgtgaa aatcacacct
    18781 gcccacgatc caaatgactt cttggttggc caacgtcata acttgccaca agtcaacgtc
    18841 atgaacgacg acggaactat gaatgagctt gcctttgaat tttcaggcat ggatcgtttt
    18901 gaagctcgta aggcagtcgt tgctaagttg gaagaaatcg gtgcccttgt caaaatcgaa
    18961 aaacgtgtcc acagtgttgg tcactcagaa cgtacaggtg tcgtagttga gccacgcttg
    19021 tctactcaat ggttcgtcaa gatggaccaa ttggctaaga acgccattgc caaccaagac
    19081 acagaggaca aggtcgaatt ctacccacct cgtttcaacg ataccttcct tcaatggatg
    19141 gaaaatgtcc acgactgggt tatctctcgt cagctttggt ggggtcacca aatccctgcc
    19201 tggtacaatg ctgatggtga aatgtatgtc ggcgaagaag ctccagaagg tgacggatgg
    19261 actcaggacg aagacgtctt ggatacttgg ttcagttctg ccctctggcc attttcaacc
    19321 atgggctggc ctgaagtcga ctcagaagac tttaaacgtt atttcccaac ttcaaccttg
    19381 gtaacaggtt acgacatcat cttcttctgg gtgtctcgta tgatcttcca gtcattggaa
    19441 ttcacaggcc gtcaaccatt ccaaaacgtc cttatccacg gtcttattcg tgacgagcaa
    19501 ggacgcaaga tgtctaagtc tctcggtaac gggattgacc caatggatgt tatcgagaaa
    19561 tacggtgccg atgcccttcg atggttcctt tcaaacggtt ctgcgccagg acaagacgtg
    19621 cgtttctctt atgagaaaat ggatgcttca tggaacttta ttaacaagat ttggaacatt
    19681 tctcgctata tcctcatgaa caatggaggt ttgacgctgg atgtggcgca tgacaatgtc
    19741 acaaaagttg caacaggtga ggctggtaat gtgacggacc gctggattct ccacaacctc
    19801 aatgaaacga ttggaaaagc aactgctaac tttgataagt ttgagtttgg tgttgctggc
    19861 cacatcctct acaacttcat ctgggatgaa tttgcggact ggtatgttga gttgaccaag
    19921 gaagtccttt atagcgataa tgaagaagat aaggtaatta ctcgatctgt tctcctttac
    19981 actctggaca agatccttcg tctccttcac ccaatcatgc cattcgtgac agaggaaatc
    20041 tttggacaaa tctcagaagg ttctatcgtg acagctgcat acccaactgt taatctagcc
    20101 tttgaagacc ttgcggctca cactggtgta gaaagtctca aagacttgat ccgtgccgtt
    20161 cgtaatgcgc gtgcggaagt aaatgtagca ccaagcaaac ctattacaat ccttgttaag
    20221 actagcgata gtgacttgga agccttcttt aacagcaatg tcaactacat caaacgcttt
    20281 acaaatccag aacatttgga aatcgcatca accatccctg cacctgaact ggctatgtca
    20341 agtgtcatca caggagcaga aatctacctg ccactggccg atctcctcaa tgttgaagaa
    20401 gaactagatc gtctcgacaa agaactcgct aaatggcaaa aagaactgga catggttggt
    20461 aagaaactct ctaacgaacg cttcgtagcc aacgccaaac cagaagtcgt ccaaaaagaa
    20521 cgcgacaaac aagctgacta ccaagccaag tatgatgcga ccgtagcacg tattgatgag
    20581 atgaagaaac tcgttaaata aacacagaaa cacggtgatg agccgtgttt ttttggtata
    20641 atgaaatcaa tatctattga tggagaaagt gatgtccaaa caccctcatt atgaattgtt
    20701 aaatttaatt ggctacggtc ttgccaagtt tgacaagctt tttataaaag aatttcaatg
    20761 ctctagcaag tcggagtttt atcgttatgt ggtttctctg ggaattgctg aaacaactgg
    20821 agttgtaaaa aatagaatgg atttatttga tccttatttt gacaataatc gaaaaggttg
    20881 gtggcagaaa gctgaagttt atcgttttcg taaagattta attgatatga tgtttggaaa
    20941 tgaagatgtt catagttatg ctgaaatagt taaaatgtta cttgccagtg aagggaagaa
    21001 aacaggcata accatcgttg aaaaaccaat agttcgaact aaattcaaac gtctacagga
    21061 aacgggaatg gaggctgaga attattttat ccttcatttt gataaagaag aaaaattcca
    21121 aggtggacag ttaaccgatg cccgtcttta tggtgatgga tatgactttc aggtagatgt
    21181 ccaagagtat tcttaccttg ccgaagtaaa aggtatccga aaatctaagg ggcgtgtgcg
    21241 tttaactgca aaagaatttg aaaaagtcaa ggagtttcaa tcggatttta ttttatcctt
    21301 ggtcacaaat ctagatgata ttccaaagtt agtgttaatc gataatcctt taaaacattt
    21361 tgagtttaaa aagaatatta tcaaaaatga aatcattgaa tatagaagct tagaagattt
    21421 gtattagttc cccccttaac ttttccagtt gaaagaacga gaagtcttga caggtcaacg
    21481 actcaatgaa ctggaaatca acggtattcg tttaactaaa tttaaaaatg gggaaatcgg
    21541 tattgaattt atctggattg ataccgaaaa tcccccaagc gatgccatcg gctgggtagc
    21601 aaagaaataa aagttttcaa aggtattgta acaaataagg gattttattt tcgtgtacaa
    21661 tttcagctat tcttgttata atcagcctat aggaatcaag gaggtgactc ttatggctgt
    21721 ttttgtgtct ttggatggaa ttgtggtaga agtacttgat gtcttttctt cttttgatgg
    21781 ggatagtgag tttttcttgt gtaaacgtct taaagacaag agtcagtttg ttatggaacg
    21841 ctctcagttc gaggagatgt tccaacttca aagtagtcgc ttgacgacgc aagaaaaatt
    21901 acaattgttt acctctgtgt ttgctggccg ttatgatgtt tatgctaaga gttttatcaa
    21961 tgatcaaggg aaaattcagt attttccttc ctatgattat ggttggaagc agttgctacc
    22021 tgaaaaacgg agtttccaga cattgacgga ttccgttttg aaatctcatt ttcgtgggga
    22081 ggcagctatc ggtatctttc ctatgcactt agatgatagc tgttattttt tggtactgga
    22141 tttggatgaa ggagattgga aagaagctgg tttaaccatt cgaagaatag ccagggaacg
    22201 ccagatggaa gcccatttag agatttctcg ttcgggttac ggactccata tttggttctt
    22261 ctttgaggaa gcgattctga gtcgaaaggc tcgcctgttt ggaaagaaac tattagaatt
    22321 ggcaatgcag gaaagtatgc aactgtcctt tgattctttt gatcgcatgt ttccaaatca
    22381 ggatgtcctt cctaaggggg gatttggaaa tttgattgcc ttgccttttc aaggagaagc
    22441 ttaccatcaa gggcgaacgg tctttgtgga tgaacagttt cagccttatg aagaccaatg
    22501 gaggtatcta caagaaattc agaggatttc aactgctaaa gtggcactgt taatccaaga
    22561 ggagttaggc aagcaagaat tggataagga gttgaaggtc gttttatcca atatgatcca
    22621 acttgaaaaa tcgtctgtga catccaaggc acttttttct tgaaaaatat ggcttccttt
    22681 tctaatcccg aattttatag tagattgaaa ctagaatagt acacctctgc ttctaaaaca
    22741 ttgttagaaa tcgatttgac tttcctgatc gatttgtcct gttattattt cattttacta
    22801 tatttaaagc aggctatgcg acagccaacc tatcaaattc ctgagagaat gtatttattt
    22861 ggagaatccg atcattattt atggttgcca agaggtttgc tgtatccatt gcaagataaa
    22921 tttaagcagg tatctgtgga agataggaga aaggtacaaa ggtctattag cgtggaattt
    22981 aagggagaac tcacttttga gcaagagtta gccctgtcag atatgacttc taaagaaaat
    23041 ggtttacttc atgcggagac tggttttggg aagaccgttt taggtgctgc tcttatctct
    23101 gaacggaaaa caaaaacaat tattctagtc cataataagc aactcttaga ccaatggcta
    23161 gatcgcttaa actgcttttt gactttcgaa gaggaggagg ctatccgtta tacggcatca
    23221 ggtcgtgaaa aggtaatcgg ctatgttggg cagtacggtg ggactaagaa atggctgagt
    23281 aaactggttg atgtcgttat gattcaatct ctatttaagt tggaaaatag tcaaagtctt
    23341 ttggatgagt atgagatgat gattgtggat gagtgtcatc atgtctctgc cttgatgttt
    23401 gaaaaagttg ttgctcagtt tagagggaag tatctttacg gtttgacggc tacgcctgag
    23461 cgtaagaatg gtcatgagcc tattgttttt cagagaattg gtgagatact ccatactgct
    23521 gataagaggg aaacggattt taaacggcaa ttgcaattaa gattcacttc ttttggtcat
    23581 ttggaaattg aaaagaccaa agcaagtaat tttatacagc ttagtgattg gattgctact
    23641 gactcagtga ggaatcagat gattctcaag gatattctag cccaagtggc agaaggacgg
    23701 aatatcttgg ttttagttaa tcgaattcaa cagatagatg tctttgaaaa attattgaaa
    23761 gagaaagagg ttgatgactg ttacattatt agcggaaaaa ccaaagtccg agagagaacg
    23821 agtttactgg agacgttaga acagttagat aaagggtttg ttttgttgtc tactggaaaa
    23881 tacattggcg aaggttttga cttacctcag ttggacacgc ttatcttggc agcacccttt
    23941 tcttggaaaa ataatttgat tcagtatgca ggttggattc atagaaacta caaggataag
    24001 tctttggtgc gtattttcga ttatgtggat attcatgttc cttatttaga aaagatgttt
    24061 cagaaacgac aagtagctta tcgaaagatg gattatcgtg ccattgaggg tgaggagaaa
    24121 caattcgttt atgttgatag tagatatgag aaggtgttga gagaggactt agcaggggaa
    24181 agacaggaat gtctgcttat tttaccttat gtgcaccaga caaaactgat gaattttcta
    24241 aaagaattta ggattagtca aattgagata tgtataccag agacggttgc aaataaagca
    24301 tggctagacc agttgaagag ccagaaaatt aaagtgtctt ttactcaatc aaaaatagta
    24361 acgcctattc ttttggtgaa taagactatt gtttggtatg gtgcaatgcc attattaggg
    24421 aaggtagatg agatgaccat attacgtttg gaatcagcta gtatagtttc tgaactagtg
    24481 gcaggtttac gatagagaaa atttttaaaa atttctatgt atgattttca tttctttagt
    24541 gagactgttg ccattatcac attcgaatca cacaaaataa aaaaattttt ataagtactt
    24601 gacaaataga ttgaaatatc ataaaataaa aacggttaca gagttattaa ttatttaagc
    24661 ttcatgtcac cattaaaaat tgaaataaaa ggatgttatc actaatacaa gtgagcagga
    24721 acctatttaa tcacatcaga agaagtttct tgatgttttt aagtaggttc cttttatttt
    24781 aaaagggaaa ttttatgatc ataaaacgaa tactaaacca caatgccgta attgcgcaaa
    24841 gtaaaaaaga tatcgatatt cttctttttg gaaggggaat agcttttgga agaaaaactg
    24901 gagataaagt aaatccaatt gatattgaga aaagtttttt tctcaaaaat agagataata
    24961 tgacccgttt tacagagatg tttattaacg ttcctttgga gttggtgtac atcaccgaaa
    25021 aaataattaa cctaggtaaa ataacattgg gtaataattt tgatgaaatt atctatatta
    25081 atttaacgga tcatatttct tcgagcatag aacgttataa agaagggatt attatttcga
    25141 atcccctacg ctgggaaata tcgaaatatt ataaagaaga atttgaactt gggaaaaggg
    25201 ctttacaaat aataaaaaaa gagttaggta ttgaacttcc aattgacgaa gctgcattca
    25261 tagcgctaca ttttgttaat gctaatttag aaaataattt tcaagagtcg tataaaatca
    25321 ctgaaataat tatgggaatt gagaaaatca ttcaagattt ctattgtact gagtttaacc
    25381 aagattctat tgattattat agattcataa ctcatataaa attatttgcc catcgcttgg
    25441 ttgaaaatac aacttattgt gacgatgatg atgaagactt gttagcatta atgaaaaata
    25501 aatatcctag agaatatgaa tgtggtgaac aggtagcaat gtttatacaa acggagtaca
    25561 attatttgct gacttctagt gaattagctt atttgatggc tcatattcgt cgcttaacaa
    25621 aaaatttaga ttaatagaat aggagaatac catgagttat aaagatacgg tacaaaaaat
    25681 cctcgatgta attggaggtg aaaaaaatgt caatagagtt acccattgtg taacacgttt
    25741 aagattagaa ttaaaagatg aaaatttagt caatgatgat gatgtgaaga agataccagg
    25801 tgtaataggt attatgaaaa agaatggaca atatcaaatt atacttggta atgatgtagc
    25861 taattattat aaagaattcg ttaaacttgg caattttgaa tccgattcag ttgttcaagg
    25921 gcacaaaggg aatattttag aaagaatcat tgagtatatc gctggttcca tgactccaat
    25981 cattccagca atgttagggg gaggtatgtt gaaagtcttg gtaatcattt taccaatgct
    26041 tggtatattg caatcagatt ctcagactat tgcttttttg acattttttg gggatgctcc
    26101 atattatttc ttaccgctgt tattagctta ttctgcatca caaaaattaa aagtaacatc
    26161 tacattagct atgtctgtag caggtgtact tctccatcca aattttgttc aaatggtgca
    26221 atcagggaat cctcttagtt tatttggtgc acctgtgaca ccagctagtt atggttcatc
    26281 agtcgttcca attcttatta tggtttggtt gatgaaatat attgaaaaaa taattgctaa
    26341 attaacacta gctattacta agagtttttt gcaacctacg ctagtattat tagtatcaag
    26401 ctgtattgcc ttagttgtag tcggacctat tggagtaatt gttggtgaag gattatcaaa
    26461 tctagttggg caaatgtatg gtgtagctgg atggcttaca ttagctattc ttggtgctat
    26521 tatgccattt attgttatga ctggaatgca ttgggctttt gcacctattt ttttggcggc
    26581 atctattgct actccagacg tattaattct tccagcaatg ttagggtcaa acttagctca
    26641 aggggctgct tcgatggctg ttgcattaaa gagtaaaaat aataatacaa aacaaattgc
    26701 ttttgcagca ggtttctcag ccttacttgc agggattacc gaacctgcat tatatggtgt
    26761 gactttaaaa tataaaaaac cgctttatgc agctatgatt ggtggtggat tagcgggatt
    26821 atttgcaggt cttactagtg ttaaagcata tctatttgct gtcccatctt tgatagcgtt
    26881 gcctcaattt atttattctg atgtgccatc aaatattgta aatgctttaa ttgtggcggt
    26941 catttcggtt gttattacct ttgtattagc ttatatattt ggaatcgatg aagaagagag
    27001 ttctagcaat ttagaagttg aagctggagt ttcaaataaa aaaatgatat tttctcctat
    27061 atcaggagaa atcattccgt taagcgatgt ccaggataaa acattttcag ataaactaat
    27121 tggagacgga gtagcgatta tcccaagtga aggtaaggtt tatgcaccat ttgatgggaa
    27181 aattacaaat atttttccga ctaagcacgc aattggattg aagagtgatg agggtgttga
    27241 gttactaatt catattggat tagatactgt tgagctaaaa ggtcaaggtt ttattagtca
    27301 tgtagaagaa ggagacagag ttttcaaaaa tcagttgatt tttgaaatgg acttgaattt
    27361 aatcaagact aaaggctacg aaacagttac accagtaatt gtaacgaata ccaatgattt
    27421 tctagatgta ttagtattac ctaataatca gacaatcgag cattctaagg aattactggt
    27481 aatattataa tggaggaaag ttatgaccat ttttccagat gattttcttt ggggtggagc
    27541 tgttgcagct aatcaagtag agggagcata taatgaagat ggtaagggct tatcagttca
    27601 ggatgtgtta cccaaaggtg gattaggaga agcaacagaa aatcctacag aagataactt
    27661 aaaattgata ggtattgatt tttatcataa atataaggaa gatatatcct tgttttctga
    27721 aatgggcttt aatgtttttc gtacttctat tgcatggagt agaatttttc caaaaggaga
    27781 tgaggaagaa cctaacgaag ctgggttgaa atattatgat gaattgtttg atgaactaca
    27841 tgctcacggg atagaaccac ttgtaactct ttcacactat gagactccat tatatttagc
    27901 aagaaaatat catggatggg ttgataggag aatgattcat ttttatgaaa aatttgctcg
    27961 aacagtttta gaaaggtata aagataaagt taaatattgg cttacattta acgaagtaaa
    28021 ctctgttttg gaattaccat ttactagtgg aggaatagat atacctaagg agaatctttc
    28081 gaaacaagaa ttatatcaag ctatacatca tgaattagtc gcctcaagtt tggttacaaa
    28141 aattgctcgt gagattaatt cagagtttaa ggtgggatgt atggtattag ctatgccagc
    28201 ttatccaatg actccaaatc caaaagatgt atgggtgact catgagtatg agaatctaaa
    28261 ttatctattt tcagatgtgc atgttagagg ttattatccg aattatgcaa aaagatattt
    28321 taaggaaaat gacattaaca tagagtttgc agctgaagat gcagagttat taaaaaatta
    28381 taccgtagat tttttatcct ttagctatta catgagtgtg actcaatctg ctcttccaac
    28441 acagtataat tcaggagaag ggaatattat tggtggttta gtaaatcctt atttagagtc
    28501 ttcagagtgg ggatggcaaa ttgatccaat tggactacgt ataattttaa atagatatta
    28561 tgaccgttat caaatcccat tatttatagt agaaaatgga ttaggtgcta aagatcaact
    28621 aataaaagat gaacttaata acttaaccgt ccaagatgat tatagaattc agtatatgaa
    28681 agaacattta ttgcaagttg ctgaagctct acaggatggt gttgaaatta tgggctatac
    28741 gtcttgggga tgtattgact gtgtttctat gtccactgca caactttcta aaaggtacgg
    28801 tctcatttat gttgatcgaa acgatgatgg aagtggtaca ttaaatcgat ataagaaaat
    28861 gtcttttact tggtataaag aagtgattga atcaaatgga gaatccttat tcaaatagtt
    28921 ttttattgat gactagctat tatcacggtt aaggtggcat ttcattaaat atggaataaa
    28981 gaagtttgga agacattaaa ttctaaactt ctttatttta taggggagtg tcaattaatt
    29041 taattttgtt acaaaaatta taaatagtta atttagataa attgtttata taaatttaga
    29101 taagaataag ctaacaagca gaagtaagat aggtcttgca agaatggtaa aaatctgata
    29161 aactaagtag taattgaata ggaatctgaa agactagtag cccaagggaa gtatatcagg
    29221 gaggagagcc gtgactgcaa gctctctata tgaaagctgg gtgaattcac ttgcgcatgg
    29281 atttagaaat gaaggtctga cttgtcagat gaaaacggat ggtaccgcgt gtcaacgctc
    29341 cgagtggagt ttttggcatg tggttttctt tttatctacg agagactgat ggaggaaata
    29401 tgtcaactat tgaagaacaa ttaaaagcgc ttcgcgaaga aacgctggct agcttgaagc
    29461 agattactgc tggaaatgaa aaagagatgc aagatttgcg tgtctctgtc cttggtaaaa
    29521 agggttcgct cactgaaatc ctcaaaggga tgaaagatgt ttctgctgag atgcgtccaa
    29581 tcatcgggaa acacgtcaat gaagctcgtg atgtcttgac tgctgctttt gaagaaacag
    29641 ctaagctctt ggaagaaaag aaagtcgcgg ctcaactggc tagcgagagt at
//
LOCUS       DBMVGT010000019        29271 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.019, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000019 DBMVGT010000000
VERSION     DBMVGT010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 29271)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 29271)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..29271
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.019"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            2..1168
                     /locus_tag="AC0DU4_000924"
     CDS             2..1168
                     /locus_tag="AC0DU4_000924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HIN4236906.1"
                     /translation="MLLASTVALSFAPVLATQAEEVLWTARSVEQIQNDLTKTDNKTS
                     YTVQYGDTLSTIAEALGVDVTVLANLNKITNMDLIFPETVLTTTVNEAEEVTEVEIQT
                     PQADSSEEVTTATADLTTNQVTVDDQTVQVADLSQPIAEAPKEVASNSEVAETVTAAE
                     EVAPSTGTSVPEEQTAETTRPVEEVAPQATTLAEKQETQVSSQTESAVEATTMPVEEK
                     ATETTATSSEAKEVASSNGATAAVSTYQPEETKTISTTYEAPAAPDYAGLAVAKSENA
                     GLQPQTAAFKEEIANLFGITSFSGYRPGDSGDHGKGLAIDFMVPESSELGDKIAEYAI
                     QNMASRGISYIIWKQRFYAPFDSKYGPANTWNPMPDRGSVTENHYDHVHVSMNG"
     gene            1596..2019
                     /locus_tag="AC0DU4_000925"
                     /pseudo
     CDS             1596..2019
                     /locus_tag="AC0DU4_000925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000890080.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
     gene            2030..2398
                     /locus_tag="AC0DU4_000926"
     CDS             2030..2398
                     /locus_tag="AC0DU4_000926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1304 domain-containing protein"
                     /protein_id="HIN4236907.1"
                     /translation="MSIITIILTTIVAWEHFYIFYLESIATQSDATSRVFNMEREELA
                     HPSVSLLFKNQGIYKALLGVCLLYGIYFSQNLEIVTIFVLFVIGAATYGSLTADKKII
                     LKQGGSAILALISILLFKYT"
     gene            2505..3123
                     /locus_tag="AC0DU4_000927"
                     /pseudo
     CDS             2505..3123
                     /locus_tag="AC0DU4_000927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
     gene            complement(3151..4008)
                     /locus_tag="AC0DU4_000928"
     CDS             complement(3151..4008)
                     /locus_tag="AC0DU4_000928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HIN4236908.1"
                     /translation="MNYPKIDLKTIRQESKHFQADTPRLFLLYILPSMLVILSSFLNP
                     LSRIHGTVLEQPFFSILGQILQTYLFPLLVSFIGTILLTSSVYATLTLMKDSKTEPSV
                     KNSLALFDEERFSQTFLTLLLKRFYLFLWSIPNLLGIYLLFYSSFLAKKFVTLHPEFP
                     NLDLSSVETERFLMVFGLYFLASLILIIVGNILYIPQYYAYSQVEFLLCYSLDLGQVP
                     PRRILKTSRSFMKGYKFQRFVLDLQLLPWYFLNWITFGIASFSLLPYIQCTKIMFYRA
                     VLARKRPKA"
     gene            4138..5280
                     /gene="tgt"
                     /locus_tag="AC0DU4_000929"
     CDS             4138..5280
                     /gene="tgt"
                     /locus_tag="AC0DU4_000929"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004298827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008479 - tRNA-guanosine(34) queuine
                     transglycosylase activity [Evidence IEA];
                     GO_process: GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HIN4236909.1"
                     /translation="MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQAT
                     VKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQV
                     YSLADSRNITEEGVTFKNHLNGSKMLLSPEKAISIQNNLGSDIMMSFDECPQFYQPYD
                     YVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSI
                     GGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTR
                     IARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIR
                     LTSYHNLYFLLNLMKQVRQAIMDDNLLEFRKYFVEKYGYNKSGRNF"
     gene            5381..7198
                     /locus_tag="AC0DU4_000930"
     CDS             5381..7198
                     /locus_tag="AC0DU4_000930"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase family protein"
                     /protein_id="HIN4236910.1"
                     /translation="MRIKWFSLVRITGLLLVLLYHFFQTIFPGGFFGVDVFFTFSGFL
                     ITALLIEEFSKNHEIDLIGFFRRRFYRIVPPVVLMVLVTMPFTFLVRQDYVAGIGGQI
                     ASVLGFMTNFYELLTGGSYESQFIPHLFVHNWSLAVEVHYYILWGLAVWFLSKQAKSN
                     GQLKGMVFLLSAVAFLISFFSMFIGSFLVTSYSSVYFSSLTHVYPFFLGSMLATIVGV
                     RQTTSLVKQLDKIWDLRKTLVVFGGGFGFLVLLTFFVKFTYLFAYLIGFLLASLAALA
                     MILAARVLHEKTHHIQEPKIISFLADTSYAVYLFHWPFYIIFSQLTSNLLAVLLTLIC
                     SYGFASLSFYVLEPWIAGKNTPIVQTLRPLPYIHAILAAGTGILTIIVCTVTLLAPQV
                     GAFETDLTVNGLKQAATNIGQTKVMAERADANSLGIADGTMLIGDSVALRANTALQTA
                     LPGAQINAQVSVTTKTANEIMLNNSQNKFLPKTVVIATGVNNPENYKDDWDSIVKNLP
                     KGHHMILVTPYEGDKTKETYAIVEKAAAYMRELAEKTPYITIADWNQVAKEHPEIWAG
                     TDQVHFGSESSTIEAGAKLYADTIATALQTAQDKPVKSK"
     gene            7351..8502
                     /gene="nagA"
                     /locus_tag="AC0DU4_000931"
     CDS             7351..8502
                     /gene="nagA"
                     /locus_tag="AC0DU4_000931"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008448 - N-acetylglucosamine-6-phosphate
                     deacetylase activity [Evidence IEA];
                     GO_process: GO:0006044 - N-acetylglucosamine metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HIN4236911.1"
                     /translation="MPNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQIPEGAEVID
                     YTGYSIAPGLVDTHIHGYAGVDVMDNNIEGTLHTMSEGLLSTGVTSFLPTTLTATYEQ
                     LLAVTENLGNHYKEATGAKIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAA
                     NGLLNKIALAPERDGVEDFVRTVTGEGVTVALGHSNATFDEAKKAVDAGASVWVHAYN
                     GMRGLTHRELGMVGAMYQLPHTYAELICDGHHVDPKACEILIKQKGTENIALITDCMT
                     AGGLEDGDYMLGEFPVVVANGTARLKSTGNLAGSILKLKDGLKNVVEWGIANPHEAVM
                     MASFNPAKSVHIDDVCGQIREGYDADFIVLDKDLELVATYLDGVKRYQA"
     gene            8665..9723
                     /locus_tag="AC0DU4_000932"
     CDS             8665..9723
                     /locus_tag="AC0DU4_000932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="HIN4236912.1"
                     /translation="MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHI
                     IKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYA
                     HCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGV
                     LKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVN
                     SSDPEKAIKEIYDLTDGRGVDVAIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEF
                     DLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSK
                     AADHHAIKVIIENDISEA"
     gene            9874..10239
                     /locus_tag="AC0DU4_000933"
     CDS             9874..10239
                     /locus_tag="AC0DU4_000933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1033 family protein"
                     /protein_id="HIN4236913.1"
                     /translation="MYRVIEMYGDFEPWWFLEGWEEDIVASRKFDQYYDALKYYKTCW
                     FRLEQESPLYKSRSDLMTIFWDPEDQRWCDECDEYLQQYHSLALLQDEQVIPDEKLRS
                     GYEKQTSQERNRSCRMKLK"
     gene            10315..11256
                     /gene="comGA"
                     /locus_tag="AC0DU4_000934"
     CDS             10315..11256
                     /gene="comGA"
                     /locus_tag="AC0DU4_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000249584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus ATPase ComGA"
                     /protein_id="HIN4236914.1"
                     /translation="MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIG
                     SYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKMASLRLSTVGDYRGHESL
                     VIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
                     VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDIETARAVV
                     RASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFAN
                     RDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS"
     gene            11204..12220
                     /gene="comGB"
                     /locus_tag="AC0DU4_000935"
     CDS             11204..12220
                     /gene="comGB"
                     /locus_tag="AC0DU4_000935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000355375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus assembly protein ComGB"
                     /protein_id="HIN4236915.1"
                     /translation="MDISQVFRLRRKKLATAKQKNIITLFNNLFSSGFHLVETISFLD
                     RSSLLDKQCVTQMRTGLSQGKSFSEMMESLGCSSTIVTQLSLAEVHGNLHLSLGKIEE
                     YLDNLAKVKKKLIEVATYPLILLGFLLLIMLGLRNYLLPQLDSSNIATRIIGNLPQIF
                     LGMVGLVSVLALLALTFYKRSSKMSVFSILARLPFIGIFVQTYLTAYYAREWGNMISQ
                     GMELTQIFQMMQEQGSQLFKEIGQDLAQTLKNGREFSQTIGTYPFFRKELSLIIEYGE
                     VKSKLGSELEIYAEKTWEAFFTRVNRTMNLVQPLVFIFVALIIVLLYAAMLMPMYQNM
                     EVNF"
     gene            12222..12548
                     /gene="comGC"
                     /locus_tag="AC0DU4_000936"
     CDS             12222..12548
                     /gene="comGC"
                     /locus_tag="AC0DU4_000936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="comG operon protein ComGC"
                     /protein_id="HIN4236916.1"
                     /translation="MKKMMTFLKKAKVKAFTLIEMLVVLLIISVLFLLFVPNLTKQKE
                     AVNDKGKAAVVKVVESQAELYSLEKNEDASLRKLQADGRITEEQVKAYNEYYTKNGGA
                     NRKVND"
     gene            12541..12945
                     /gene="comGD"
                     /locus_tag="AC0DU4_000937"
     CDS             12541..12945
                     /gene="comGD"
                     /locus_tag="AC0DU4_000937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus minor pilin ComGD"
                     /protein_id="HIN4236917.1"
                     /translation="MIKAFTMLESLLVLGLVSILALGLSGSVQSTFAAVEEQIFFMEF
                     EELYRETQKRSVASQQKTSLNLDGQTLSNGSQKLTVPKGIQAPSGQSITFDRAGGNSS
                     LAKVEFQTSKGAIRYQLYLGNGKIKRIKETKN"
     gene            12908..13210
                     /gene="comGE"
                     /locus_tag="AC0DU4_000938"
     CDS             12908..13210
                     /gene="comGE"
                     /locus_tag="AC0DU4_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413380.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus minor pilin ComGE"
                     /protein_id="HIN4236918.1"
                     /translation="MEKLNALRKQKIRAVILLEAVVALAIFASIATLLLGQIQKNRQE
                     EAKILQKEEVLRVAKMALQTGQNQVNINGVEIQVFSSEKGLEVYHGSEQLLAIKEP"
     gene            13173..13634
                     /gene="comGF"
                     /locus_tag="AC0DU4_000939"
     CDS             13173..13634
                     /gene="comGF"
                     /locus_tag="AC0DU4_000939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000250539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus minor pilin ComGF"
                     /protein_id="HIN4236919.1"
                     /translation="MVQNSCWQSKSHKVKAFTLLESLLALIVISGGLLLFQAMSQLLI
                     SEVRYQQQSEQKEWLLFVDQLEAELDRSQFEKVEGNRLYMKQDGKDIAIGKSKSDDFR
                     KTDASGRGYQPMVYGLKSAQITEDNQLVHFRFQFQKGLEREFIYRVEKEES"
     gene            13612..14058
                     /gene="comGG"
                     /locus_tag="AC0DU4_000940"
     CDS             13612..14058
                     /gene="comGG"
                     /locus_tag="AC0DU4_000940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001851880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence type IV pilus minor pilin ComGG"
                     /protein_id="HIN4236920.1"
                     /translation="MWKKKKVKAGVLLYAVTIAAIFSLLLQFYLNRQIAHYQDYALNK
                     EKLVAFAMAKRTKDKAEQESGEQVFNLGQVSYQNKKTSLVTTVRTSKSQYEFLFPSVK
                     IKEEKRDKKEEVATDSSEKAEKKNQKRSLKRKRIPSQFNYNALNPE"
     gene            14161..14755
                     /locus_tag="AC0DU4_000941"
                     /pseudo
     CDS             14161..14755
                     /locus_tag="AC0DU4_000941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679792.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
     gene            14816..15769
                     /locus_tag="AC0DU4_000942"
     CDS             14816..15769
                     /locus_tag="AC0DU4_000942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000345081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HIN4236921.1"
                     /translation="MDFEKIEQAYIYLLENVQVIQSDLATNFYDALVEQNSIYLDGET
                     ELNQVKDNNQALKRLALRKEEWLKTYQFLLMKAGQTEPLQANHQFTPDAIALLLVFIV
                     EELFTEEEITILEMGSGMGILGATFLTSLDKKVDYLGMEVDDLLIDLAASMADVIGLQ
                     AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGF
                     KYLKSDGYAIFLAPSDLLTSPQSDLLKVWLKEEASLVAMISLPENLFANAKQSKTIFI
                     LQKKSEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI"
     gene            15820..17010
                     /locus_tag="AC0DU4_000943"
     CDS             15820..17010
                     /locus_tag="AC0DU4_000943"
                     /EC_number="2.7.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008776 - acetate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006085 - acetyl-CoA biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HIN4236922.1"
                     /translation="MTKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTV
                     KFDGRSEQQILDIENHTQAVKILLDDLIRFDIIKAYDEITGVGHRVVAGGEYFKESTV
                     VEGDVLEKVEELSLLAPLHNPANAAGVRAFKELLPDITSVVVFDTSFHTSMPEKAYRY
                     PLPTKYYTENKVRKYGAHGTSHQFVAGEAAKLLGRPLEDLKLITCHIGNGGSITAVKA
                     GKSVDTSMGFTPLGGIMMGTRTGDIDPAIIPYLMQYTEDFNTPEDISRVLNRESGLLG
                     VSANSSDMRDIEAAVAEGNHEASLAYEMYVDRIQKHIGQYLAVLNGADVIVFTAGVGE
                     NAESFRRDVISGISWFGCDVDDEKNVFGVTGDISTEAAKIRVLVIPTDEELVIARDVE
                     RLKK"
     gene            17011..17142
                     /locus_tag="AC0DU4_000944"
     CDS             17011..17142
                     /locus_tag="AC0DU4_000944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000768902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236923.1"
                     /translation="MKLKKYSIQGVGKVIFPASFSDEIVQNLAMIGFFEKYGIIVVI"
     gene            17159..17530
                     /gene="rnpA"
                     /locus_tag="AC0DU4_000945"
     CDS             17159..17530
                     /gene="rnpA"
                     /locus_tag="AC0DU4_000945"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000049 - tRNA binding [Evidence IEA];
                     GO_function: GO:0004526 - ribonuclease P activity
                     [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HIN4236924.1"
                     /translation="MKKNFRVKREKDFKAIFKEGTSFANRKFVVYQLENQKNHFRVGL
                     SVSKKLGNAVTRNQIKRRIRHIIQNAKGSLVEDVDFVVIARKGVETLGYAEMEKNLLH
                     VLKLSKIYREGNGSEKETKVD"
     gene            17505..18329
                     /locus_tag="AC0DU4_000946"
     CDS             17505..18329
                     /locus_tag="AC0DU4_000946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HIN4236925.1"
                     /translation="MKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKLVYF
                     FAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQMVASRKMQEAQPRIKALREQYP
                     GRDMESRTKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGHFL
                     WINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAP
                     GGVALYWTVSNAYQVLQTYFLNNPFKIIAEREAVVQAQKDLENRKRKAKKKAQKTK"
     gene            18348..19334
                     /gene="jag"
                     /locus_tag="AC0DU4_000947"
     CDS             18348..19334
                     /gene="jag"
                     /locus_tag="AC0DU4_000947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000260012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding cell elongation regulator Jag/EloR"
                     /protein_id="HIN4236926.1"
                     /translation="MVVFTGSTVEEAIQKGLKELDIPRMKAHIKVISREKKGFLGLFG
                     KKPAQVDIEAISETTVVKANQQVVKGVPKKINDLNEPVKTVSEETVDLGHVVDAIKKI
                     EEEGQGISDEVKAEILKHERHASTILEETGHIEILNELQIEEAMREEAGADDLETEQD
                     QAESQELEDLGLKVETNFDIEQVATEVMAYVQTIIDDMDVEATLSNDYNRRSINLQID
                     TNEPGRIIGYHGKVLKALQLLAQNYLYNCYSRTFYITINVNDYVEHRAEVLQTYAQKL
                     AIRVLEEGRSHQTDPMSNSERKIIHRIISRMDGVTSYSEGDEPNRYVVVDTE"
     gene            19385..20008
                     /locus_tag="AC0DU4_000948"
     CDS             19385..20008
                     /locus_tag="AC0DU4_000948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HI_0552 family protein"
                     /protein_id="HIN4236927.1"
                     /translation="MLNKIRDYLDFAGLQYRNPDKAGAEREKMLAFRHKGQEARKAFT
                     ELAKAFQASHPEWQLQQTSQWMNQAQRLRPHFWVYLQRDGQVTEPMMALRLYGTSTDF
                     GISLEVSFIERKKDEQTLGKQAKVLDIPTVKGIYYLTYSNGQSQRWEANEEKRRTLRE
                     KVRSQEVRKVLVKVDVPMTENSSEEEIVEGLLKSYSKILPYYLATRK"
     gene            20139..21596
                     /locus_tag="AC0DU4_000949"
     CDS             20139..21596
                     /locus_tag="AC0DU4_000949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HIN4236928.1"
                     /translation="MEVVSSVLNWFSSNILQNPAFFVGLLVLIGYALLKKPAHDVFSG
                     FVKATVGYMLLNVGAGGLVTTFRPILAALNYKFQIGAAVIDPYFGLAAANNKIAAEFP
                     DFVGTATTALLIGFGINILLVALRKITKVRTLFITGHIMVQQAATVSLMVLFLVPQLR
                     NAYGTAAIGIICGLYWAVSSNMTVEATQRLTGGGGFAIGHQQQFAIWFVDKVAGRFGK
                     KEESLDNLKLPKFLSIFHDTVVASATLMLVFFGAILLILGPDIMSNKEVITSGTLFNP
                     AKQDFFMYIIQTAFTFSVYLFVLMQGVRMFVSELTNAFQGISNKLLPGSFPAVDVAAS
                     YGFGSPNAVLSGFTFGLIGQLITIVLLIVFKNPILIITGFVPVFFDNAAIAVYADKRG
                     GWKAAVILSFISGVLQVALGALCVALLDLASYGGYHGNIDFEFPWLGFGYIFKYLGIV
                     GYVLVCLFLLVIPQLQFAKAKDKEKYYNGEVQEEA"
     gene            21619..21900
                     /locus_tag="AC0DU4_000950"
     CDS             21619..21900
                     /locus_tag="AC0DU4_000950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4236929.1"
                     /translation="MVKVLAACGNGMGSSMVIKMKVENALRKLNQTDFTVNSCSVGEA
                     KGLAVGYDIVIASLHLIQELEGRTNGKLIGLDNLMDDKEITEKLSQALQ"
     gene            21977..22462
                     /locus_tag="AC0DU4_000951"
     CDS             21977..22462
                     /locus_tag="AC0DU4_000951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002267837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HIN4236930.1"
                     /translation="MNLKQALIDNDSIRLGLEANNWKEAVKVAVDPLIESGAILPEYY
                     DAIIESTEEYGPYYILMPGMAMPHARPEAGVQSDAFSLITLQNPVVFSDGKEVSVLLA
                     LAATSSKIHTSVAIPQIIALFELEDSIARLQACQTKEDVLAMIEESKDSPYLEGLDLE
                     S"
     gene            22479..23144
                     /locus_tag="AC0DU4_000952"
     CDS             22479..23144
                     /locus_tag="AC0DU4_000952"
                     /EC_number="4.1.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-keto-L-gulonate-6-phosphate decarboxylase
                     UlaD"
                     /protein_id="HIN4236931.1"
                     /translation="MTKRIPNLQVALDHSDLQGAIKAAVSVGQEVDIIEAGTVCLLQV
                     GSELAEVLRSLFPDKIIVADTKCADAGGTVAKNNAVRGADWMTCICCATIPTMEAALK
                     AIKTERGERGEIQIELYGDWTFEQAQLWLDAGISQAIYHQSRDALLAGETWGEKDLNK
                     VKKLIDMGFRVSVTGGLDVDTLKLFEGVDIFTFIAGRGITEAADPAGAARAFKDEIKR
                     IWG"
     gene            23148..24011
                     /locus_tag="AC0DU4_000953"
     CDS             23148..24011
                     /locus_tag="AC0DU4_000953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000252119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016861 - intramolecular oxidoreductase
                     activity, interconverting aldoses and ketoses [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 3-epimerase"
                     /protein_id="HIN4236932.1"
                     /translation="MVRPIGIYEKATPTHFTWLERLNFAKELGFDFIEMSIDERDERL
                     ARLDWSKEERLEVVKEIYETGVRIPSICFSGHRRYPLGSKDSVLEEKSLELMKKCIEL
                     AQDLGVRTIQLAGYDVYYEEKSPQTRQRFIKNLRKACDWAEEAQVVLAIEIMDDPFIS
                     SIEKYLAIEKEIDSPFLFVYPDIGNVSAWHNDIYSEFYLGHHAIAALHLKDTYAVTES
                     SKGQFRDVPFGQGCVKWEEAFDILKETNYNGPFLIEMWSENCETVEETRAAIQEAQAF
                     LYPLIKKAGLM"
     gene            24013..24717
                     /locus_tag="AC0DU4_000954"
     CDS             24013..24717
                     /locus_tag="AC0DU4_000954"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HIN4236933.1"
                     /translation="MNQVINAMRKRVCDANQSLPKHGLVKFTWGNVSEVNRELGVIVI
                     KPSGVDYDELTPENMVVTDLDGKILEGDLRPSSDLPTHVQLYKAWSEIGSVVHTHSTE
                     AVAWAQAGRDIPFYGTTHADYFYGSIPCARSLTKDEVEVAYEKDTGLVIVEEFEHRGL
                     NPVEVPGIVVRNHGPFTWGKNPENAVYHSVVLEEVSKMNRFTEQINPRVGPAPQYILE
                     KHYQRKHGPNAYYGQK"
     gene            24896..26569
                     /locus_tag="AC0DU4_000955"
     CDS             24896..26569
                     /locus_tag="AC0DU4_000955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HIN4236934.1"
                     /translation="MVLDKASCDLLQYLMDQETSKTIMAISKDLKESRRKIYYHIDKI
                     NAALGDEALHIISIPRIGIHLTEEQRDACCKLLSEVDSYDYIMSAHERMMIMLLWIGI
                     SKERITIEKLIELTEVSRNTVLNDLNSIRYQLTLEQYQVILQVSKSQGYHLHAHPLNK
                     IQYLQSLLYHIFMEENATFVSILEDKMKERLDDECLLSVEMNQFFKEQVPLVEQDLGK
                     KINHHEITFMLQVLPYLLLSCHNVEQYQERHQDIEKEFSLIRKRIEYQVSKKLGERLF
                     QKFEISLSGLEVSLVAVLLLSYRKDLDIHAESDDFRQLKLALEEFIWYFESQIRMEIE
                     NKDDLLRNLMIHCKALLFRKTYGIFSKNPLTKQIRSKYGELFLVTRKSAEILEGAWFI
                     RLTDDDIAYLTIHIGGFLKYTPSSQKNMKKVYLVCDEGVAVSRLLLKQCKLYFPNEQI
                     DTVFTTEQFKSVEDIAQVDVVITTNDDLDSRFPILRVNPILEAEDILKMLDYLKHNIF
                     RNKSKSFSENLSSLISSYIVDSKLASKFQEEVQTLINQEIVVQAFLEDI"
     gene            26681..27772
                     /gene="ulaG"
                     /locus_tag="AC0DU4_000956"
     CDS             26681..27772
                     /gene="ulaG"
                     /locus_tag="AC0DU4_000956"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030145 - manganese ion binding [Evidence
                     IEA];
                     GO_function: GO:0035460 - L-ascorbate 6-phosphate
                     lactonase activity [Evidence IEA];
                     GO_process: GO:0019854 - L-ascorbic acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-ascorbate 6-phosphate lactonase"
                     /protein_id="HIN4236935.1"
                     /translation="MPNVKEITRESWILATFPEWGTWLNEEIEEEVVPEGNFAMWWLG
                     NCGTWIKTPAGANVVMDLWSNRGKSTKKVKDMVRGHQMANMAGVRKLQPNLRVQPMVI
                     DPFAINELDYYLVSHFHSDHIDPYTAAAILNNPKLEHVKFIGPYHCGRIWEGWGVPKE
                     RIIVVKPGDTIELKDMKIHAVESFDRTCLVTLPVNGADETGGELAGLAVTDEEMAQKA
                     VNYIFETPGGTIYHGADSHFSNYFAKHGKDFKIDVALNNYGENPVGIQDKMTSIDLLR
                     MAENLRTKVIIPVHYDIWSNFMASTNEILELWKMRKDRLQYDFHPFIWEVGGKYTYPQ
                     DQHLVEYHHPRGFDDCFEQDSNIQFKALL"
     gene            27886..>29271
                     /locus_tag="AC0DU4_000957"
     CDS             27886..>29271
                     /locus_tag="AC0DU4_000957"
                     /EC_number="2.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016744 - transketolase or transaldolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HIN4236936.1"
                     /translation="MSNLSVNAIRFLGIDAINKANSGHPGVVMGAAPMAYSLFTKQLH
                     INPAQPNWINRDRFILSAGHGSMLLYALLHLSGFEDVSMDEIKSFRQWGSKTPGHPEF
                     GHTAGIDATTGPLGQGISTATGFAQAERFLAAKYNREGYNIFDHYTYVICGDGDLMEG
                     VSSEAASYAGLQKLDKLVVLYDSNDINLDGETKDSFTESVRDRYNAYGWHTALVENGT
                     DLEAIHAAIETAKASGKPSLIEVKTVIGYGSPNKQGTNAVHGAPLGADETASTRQALG
                     WDYEPFEIPEQVYADFKEHVADRGASAYQAWTKLVADYKEAHPELAAEVEAIIDGRDP
                     VEVTPADFPALENGFSQATRNSSQDALNVVAAKLPTFLGGSADLAHSNMTYIKTDGLQ
                     DDTNRLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAVRLSALQGL
                     PVTYVFTHDSIA"
BASE COUNT         8984 a         5208 c         6555 g         8524 t
ORIGIN      
        1 aatgttatta gcgtcaacag tagccttgtc atttgcccca gtattggcaa ctcaagcaga
       61 agaagttctt tggactgcac gtagtgttga gcaaatccaa aacgatttga ctaaaacgga
      121 caacaaaaca agttataccg tacagtatgg tgatactttg agcaccattg cagaagcctt
      181 gggtgtagat gtcacagtgc ttgcgaatct gaacaaaatc actaatatgg acttgatttt
      241 cccagaaact gttttgacaa cgactgtcaa tgaagcagaa gaagtaacag aagttgaaat
      301 ccaaacacct caagcagact ctagtgaaga agtgacaact gcgacagcag atttgacaac
      361 caatcaagtg accgttgatg atcaaactgt tcaagttgca gatctttctc aaccaattgc
      421 agaagctcca aaagaagtag catcaaattc agaagttgca gagacagtga ctgctgcaga
      481 agaagtggca ccatctacgg gcacttctgt cccagaggag caaacggccg aaacaactcg
      541 cccagttgaa gaagtagctc ctcaggcaac gactctagct gagaagcagg aaacacaagt
      601 gagctctcaa accgagtcag cagtggaagc aactacaatg ccagtagaag aaaaagcaac
      661 cgaaacaact gcaacaagtt cagaagcaaa agaagtagca tcatcaaatg gagctacagc
      721 agcagtttct acttatcaac cagaagagac gaaaacaatt tcaacaactt acgaggctcc
      781 agctgcgccc gattatgctg gactggcagt agcgaaatct gaaaatgcag gtcttcaacc
      841 acaaacagct gcctttaaag aagaaattgc taacttgttt ggcattacat cctttagtgg
      901 ttatcgtcca ggagacagtg gagatcacgg aaaaggtttg gctatcgact ttatggtacc
      961 agaaagttca gaattagggg ataagattgc ggaatatgct attcaaaaca tggccagccg
     1021 tggcattagt tacatcatct ggaaacaacg tttctatgct ccattcgata gcaaatatgg
     1081 gccagctaac acttggaacc caatgccaga ccgtggtagt gtgacagaaa atcactatga
     1141 ccacgttcac gtttcaatga atggataaac ccgacttggt aacatcattt tgacgaatga
     1201 gatctagctt tcgtgatagg aagcgattct cgttcgtttt ttctttgtca tactcttcga
     1261 aaatctcttc aaacaacgtc agttttatct gaaacctcaa agctgtgctt tgagcaacct
     1321 gcgactagct tcctagtttg ctttttgatt ttcattgagt atcaatttga atggaaaatg
     1381 gaaagttatc atcttgtaat gagttaagca acattcttgc aatctatttt atagtagatt
     1441 gaaactagaa tagtacacaa ctgcttctaa aacattgtta gaaatcgatt tgactgtcct
     1501 gatcgatttg tcctgctctt atttcatttc actatacttt atattataat tgactggtca
     1561 aatattgata aatcaataaa aagagagggg aagaaatgct agagattcaa gatttactgt
     1621 atcaactccg cttgtctgag caagtgagta cgcaattgtt tgaaaaagct tgggattagt
     1681 ttgacacggt atcagatttt actgtttttg ctggagcatt ctctttgtaa ccaaatggcg
     1741 gttcaggagc gtttgaaaat tgatcaggct gctttgacac ggaatttcaa gattttggaa
     1801 acggaaggtt tggtggagcg tcatcgtaat cctgaaaatc agcgggaagt attggtagag
     1861 gctgcgaagt atgccaagga gcagttagtg gtgaatcccc ctctgcaaca tatcaaggtt
     1921 aaggaagaga tggaaagtat cttaacagag tttgagagaa cagaactcag ccgtttatta
     1981 aataaattgg ttttgggtat tgaaaatata gaaatttaag gagaaataga tgtcaattat
     2041 tacaattatt ttaacaacga tcgttgcttg ggagcatttt tacatttttt atttagaaag
     2101 tattgccacg caatcagatg cgactagtcg tgtatttaat atggaaaggg aagaattggc
     2161 tcatccgtca gtaagtttat tgttcaaaaa tcaagggatt tataaggctc tgctaggagt
     2221 ctgtctcttg tatggcattt atttctcaca gaatttagaa attgtgacta tttttgtctt
     2281 atttgtgatt ggtgctgcga cttacggctc tttaacagcg gataaaaaaa ttattttgaa
     2341 acaaggtgga tcagctattt tggccttgat tagtatttta ctctttaaat acacttgaag
     2401 gtcgattcta atctcgctaa tcctttttaa tccagaataa gggaaatatg ttatacttgt
     2461 ttttaagaaa aaagtttcat tgaattggtt ttgaggagtt agaaatgaaa gtattagtga
     2521 caggttttga gcccttttga ggccattaaa ggtttaccag ctgaaatcca tggtgctgag
     2581 gtccgttggc tagaggtgcc gacagttttt cacaaatctg ctcaagtatt ggaagaagag
     2641 atgaatcgtt atcaacctga ctttgtcctt tgtattgggc aagctggtgg aagaactagt
     2701 ttgacacctg aacgagtggc cattaatcaa gacgatgcac gtacttctga taacgaagat
     2761 aatcaaccga ttgaccgtcc cattcgccca gatggtgctt cggcctactt tagtagtttg
     2821 ccgattaaag cgatggttca agctataaaa aaagagggct taccggcctc tgtttccaat
     2881 acggcaggga cttttgtctg cagccatttg atgtatcagg ctctctattt ggtagaaaag
     2941 aaatttccat atgttaaggc aggttttatg catattcctt atatgatgga acaggtggtg
     3001 aacagaccga ctactccagc tatgagttta gtggatattc ggcgagggat agaagcagca
     3061 atcggcgcta tgatagaaca tggagatcag gaactcaagt tggtaggcgg agaaactcat
     3121 tgatagaaaa aagcttgagg ggaaaaacct tcaagctttt ggacgttttc gagccaatac
     3181 tgctcggtaa aacataattt tagtgcattg gatataaggt aggagtgaaa aactagcaat
     3241 gccaaaggta atccaattga ggaagtacca aggaagaagc tgtaaatcta ggacaaagcg
     3301 ctggaacttg tagcccttca taaaggaacg gctagttttt aggattcgtc ttggtgggac
     3361 ctgtcctagg tctagactat aacagagaag aaattccacc tgtgaatagg cataatactg
     3421 tggaatatag aggatatttc ctacaatgat caagatgaga cttgcaagaa agtagagtcc
     3481 aaagaccatg aggaaacgct cggtttcaac tgatgagaga tctagatttg gaaactcagg
     3541 atgtagggtg acgaattttt tggctaaaaa gctactataa aagaggaggt aaatcccaag
     3601 taaattaggg atactccata aaaagagata gaaacgtttg agaagtaggg tcaaaaaggt
     3661 ttgagaaaag cgctcctcat caaagagagc taggctgttt tttacagatg gctccgtttt
     3721 agaatctttc atgagtgtca gtgttgcata gacggaactg gtcaaaagaa tagtcccgat
     3781 aaaggagact agtagaggaa agaggtaggt ttgaagtatt tggccaagta tgctgaaaaa
     3841 tggctgttct aaaacagtcc cgtggatccg agataaggga ttaagaaaac tagataagat
     3901 gaccagcata ctgggaagga tatagaggag aaagagacgg ggggtgtcag cctgaaaatg
     3961 ttttgactcc tgacgaattg tttttaaatc aatttttgga tagttcattc tcttattata
     4021 ccatagttct tatacatagt tcgtgacagt tcctactttt tttgataaaa tcatacagtg
     4081 tgtccttggg cacactgtat gaactgggac tgtctttccc agcttcggag gtaaaaaatg
     4141 tcagattcac caatcaaata tcgtttgatt aagaaagaaa aacacacagg agctcgtcta
     4201 ggagaaatca tcactcccca cggtaccttt ccgacaccta tgtttatgcc agttgggaca
     4261 caagccactg tcaaaactca gtcacctgaa gaattgaagg agatgggttc gggaattatc
     4321 ctatcaaaca cctatcatct ctggcttcgc cctggagatg aactcattgc acgcgctggt
     4381 ggtctccaca agttcatgaa ttgggaccag cctatcttga cagatagtgg tggttttcag
     4441 gtttattctt tagcagatag ccgtaatatc acagaagaag gagtaacctt taaaaatcat
     4501 ctaaatggtt ctaagatgct cctatcccca gaaaaagcca tctctattca gaataatctg
     4561 ggttcagaca tcatgatgtc ctttgatgaa tgtcctcagt tttatcaacc ttatgactac
     4621 gttaagaaat cgatcgagcg taccagccgt tgggctgagc gtggtttgaa ggctcaccgt
     4681 cgtccacatg accaaggttt gtttggaatt gtgcaaggtg caggatttga agaccttcgc
     4741 cgccaatcag ctcatgatct tgtcagcatg gatttctcag gctactctat cggtggtttg
     4801 gcagtgggag aaacccatga agagatgaat gcggtcttgg actttacaac tcaactgctg
     4861 cctgaaaata aacctcgtta tctgatgggt gtgggagcgc cagatagctt gatcgatggg
     4921 gtcattcgtg gggtggatat gtttgactgt gtcttaccga ctcgaattgc tcgtaacggg
     4981 acttgtatga ccagtcaagg acgtttggtt gtgaaaaatg cccagtttgc tgaggacttt
     5041 acgccactgg atcctgagtg tgattgctac acatgtaata actatacacg cgcttacctt
     5101 cgtcacctgc tcaaggctga tgaaaccttt ggtatccgct tgactagcta ccacaatctt
     5161 tacttcttgc ttaacctgat gaagcaagtg cgacaagcca tcatggatga caatctcttg
     5221 gaattccgta agtattttgt ggaaaaatat ggctataata agtcaggacg taatttctaa
     5281 aatggaattg atataagcta aaaatcctaa gttttctctt aggatttttc ttcttttttt
     5341 gatagaataa agtgtacaat gaaaggaaga ataaactcgt atgcgcatta aatggttttc
     5401 cttggttagg attacaggtt tacttttggt actcttgtat cacttctttc agacgatctt
     5461 tcctggagga tttttcgggg tagatgtctt tttcacattt tcaggtttcc tgattacagc
     5521 tctactcatt gaagaatttt ctaaaaacca tgagattgat ttgataggat tttttagaag
     5581 acgcttttat cggattgtgc cacctgtggt tttgatggtc ttggtgacca tgccttttac
     5641 tttcttggtt cgccaagact atgttgctgg aattggtggc cagattgcga gcgtcttagg
     5701 ctttatgacc aacttctatg aactcctaac aggtgggagt tatgaatctc agttcattcc
     5761 tcatttgttt gttcataatt ggagtttggc agttgaggtt cactactata ttctttgggg
     5821 attggcagtt tggttcttat ccaaacaagc taaatcaaat ggtcagttga aggggatggt
     5881 ctttctctta tctgctgttg ccttcttgat cagtttcttc tccatgttta ttggtagttt
     5941 tctagtgacc tcttattcct ctgtttattt ctccagttta actcatgtct atccattctt
     6001 tttgggaagt atgttagcaa ctattgtagg cgttcgtcag acgacttccc tcgtcaagca
     6061 gttggataaa atctgggatt tacgaaagac tttggtagtt tttggaggag gctttggttt
     6121 cctagttctt ttgactttct ttgtcaaatt cacttatctt tttgcctatc ttatcggctt
     6181 cttacttgcc agtcttgcag ctcttgccat gattctggcg gcgcgtgtct tacatgaaaa
     6241 gacacatcat atacaggagc cgaagattat cagcttttta gcggatacta gctatgcggt
     6301 ttatcttttc cattggcctt tctatatcat tttctcacag ttgacatcaa atcttcttgc
     6361 tgtattactg actctgattt gttcttatgg ctttgccagt ctgtcattct atgtattgga
     6421 accttggatt gcaggcaaga acacacctat tgtccaaacc cttcgtcccc tgccttatat
     6481 tcacgcaatt cttgcagcag gtacaggaat cttgaccatc attgtctgca cggtgacctt
     6541 gttggcacca caagtgggag cgtttgagac agacttgact gtcaatggct tgaagcaagc
     6601 tgcaacaaat attggccaga ccaaggtgat ggcagaacgg gcagatgcaa acagtttggg
     6661 aattgctgat ggcactatgt taattggtga ctcagtggct ttaagggcaa atacagcact
     6721 acagacagct cttcctggag cacagattaa cgcgcaggtc agcgtaacaa ccaagaccgc
     6781 aaatgaaatc atgctaaata atagccagaa taaattttta cctaagacgg tggtcattgc
     6841 gactggggta aataatcctg agaattacaa ggatgactgg gacagtatcg tgaaaaatct
     6901 tcctaaggga caccatatga ttttggtgac tccttatgag ggagataaga caaaagagac
     6961 ctatgccatc gttgagaagg ctgctgccta tatgagagaa ttggcagaga agacacctta
     7021 cattacgata gcagattgga atcaagttgc gaaagagcat ccagaaattt gggcaggaac
     7081 agaccaggtt catttcggga gtgagagtag cactatcgaa gcaggagcaa aattgtatgc
     7141 agatacgatt gccacagctt tgcagacagc tcaagacaag ccggttaaat caaaataact
     7201 tgtattaaaa aagagaagag ttggagaaat ccagctcttt taaaatatct ccaaaaaata
     7261 ggtctatacc atttacaaat aaaaaagaaa ggtttataat gtaattgaca taataaattg
     7321 tagaatcaat cttttaagga ggttaacatt atgcctaact atattaaagc ggatcagttt
     7381 ttctacccac acggagttcg tcgaggtggt tacttggaac ttgtggacgg caagtttggg
     7441 aaacatgtag agcagattcc tgaaggggct gaggtgattg actatacagg ttatagcatt
     7501 gccccaggtc ttgtggatac tcatattcat ggatatgcag gtgtagatgt gatggacaac
     7561 aacattgaag gtacattgca tactatgagt gaaggacttc ttagtaccgg tgttaccagt
     7621 ttcttaccca caactttaac agccacttat gagcaattgc ttgcagtcac tgaaaatctt
     7681 ggaaaccatt ataaagaagc aacaggtgct aagattcgtg ggatttatta tgaaggtcca
     7741 tatttcacag aaacttttaa gggggcacaa aatccaactt atatgagaga cccgggtgtt
     7801 gaggagtttc attcttggca aaaagcggca aatggcttgc ttaataaaat tgcccttgca
     7861 ccagaacgtg atggggtgga ggactttgtt cgtacagtta cgggcgaagg tgtgacggtt
     7921 gctcttggac attcaaacgc gacttttgat gaagccaaaa aagcagtcga tgctggagcg
     7981 agtgtttggg tgcatgccta caatggaatg cgtgggttga ctcaccgtga attgggtatg
     8041 gttggagcca tgtaccaatt gccacatacc tatgcagagt tgatctgtga tggccaccac
     8101 gtagatccaa aggcttgcga aattcttatc aaacaaaaag gaacagaaaa catcgctctt
     8161 atcacagact gtatgacagc tgggggattg gaagacggag attatatgtt gggagaattc
     8221 ccagttgtcg ttgcaaatgg aactgcacgc ctcaaatcga caggtaactt ggcaggttct
     8281 atcctcaaac tcaaagatgg tttgaagaat gtggtcgaat ggggaattgc gaatccgcat
     8341 gaagcagtca tgatggccag cttcaaccca gctaaatccg ttcacatcga tgatgtctgt
     8401 ggccaaatcc gtgaaggcta cgacgctgac ttcatcgtat tagataaaga tttggaattg
     8461 gtagcaacct acctagatgg cgtaaaacgt tatcaagcat aagagagaaa gcagaagtta
     8521 gagactaact tctgcttttt tatgcagggt actttactgg taaataaaaa gttaaaaaaa
     8581 tcacaaaaaa agcttgaaga aacaaagaaa aaggcttaca attgaactat aaatattaca
     8641 aataaaaaaa cggaggagtg ctttatgaaa gcctatactt atgttaaacc aggacttgct
     8701 tcttttgttg atgtagacaa accagttatt cgcaagccaa cagatgctat tgtgcgtatt
     8761 gtaaaaacca ctatttgtgg aacagacctc catattatca aaggggatgt tcctacttgc
     8821 caaagtggta ccattcttgg ccacgaaggg attgggattg ttgaagaagt tggggaagga
     8881 gtttccaact tcaaaaaagg tgacaaggtc ttgatttctt gcgtctgtgc ctgtggtaaa
     8941 tgctactact gtaaaaaagg aatttatgct cactgtgaag acgaaggggg ctggattttc
     9001 ggtcacttga ttgatggtat gcaggctgaa tatctacgtg tccctcatgc agataatact
     9061 ctttaccata ctccagaaga cttgtcagat gaagctttgg ttatgctgtc agacattctg
     9121 cctactggat atgaaattgg tgtcttaaaa gggaaagtag aacctggttg cagcgtagcc
     9181 attattggtt caggtccagt tggattggct gctcttttaa cagcccaatt ctattcacca
     9241 gctaaattga ttatggtaga cctagacgat aaccgcttgg aaactgccct atcattcggt
     9301 gcgactcata aggttaattc ttcagaccct gaaaaagcca ttaaagaaat ttatgatttg
     9361 acagatggtc gtggtgtgga tgtcgctatc gaagctgttg gtattcctgc aacatttgat
     9421 ttctgtcaaa agattatcgg tgtagacgga acggttgcca actgtggtgt gcatggtaaa
     9481 ccagttgaat tcgatttaga taaactttgg attcgcaaca tcaatgtaac aactggtttg
     9541 gtatctacaa atacgactcc acaattgttg aaagcacttg aaagtcataa gattgaacca
     9601 gaaaaattgg taactcacta tttcaaactc agtgaaattg aaaaagccta tgaagtcttc
     9661 agtaaggcag cagaccacca tgccattaag gtcattatcg aaaacgatat ctcagaagcc
     9721 taagtagtaa aaatattttt gtacataagt aaatagaaat tcagtcatcc atcagatggc
     9781 tggatttttt atcaaaaaat taagaaatga gcatatttct ttccttgtct ggcggaattg
     9841 gttataatat acggtacaaa ggaatgaatg aatatgtatc gtgttataga aatgtacgga
     9901 gattttgaac cgtggtggtt cttagaaggt tgggaagaag atattgtagc aagtagaaaa
     9961 tttgaccagt attatgatgc tctcaaatac tacaaaactt gctggtttag attggaacaa
    10021 gaatcccctc tttataaaag tagaagcgac ttgatgacca ttttttggga cccggaagac
    10081 caacgctggt gtgatgaatg tgatgagtat ttacaacaat accattcttt ggctcttttg
    10141 caggatgagc aggttatccc agacgaaaaa ctacgctcag gctatgaaaa acaaaccagt
    10201 caggaaagga atcgttcttg ccgtatgaaa ttaaaataga gaaaagtaac ttttttggag
    10261 ttgctttttt tatttttcta acgctttgcg aatagtatag gtgaggaggt aagtatggtt
    10321 caagaaattg cacaagaaat cattcgttca gctcggaaaa aagggacgca ggatatttat
    10381 tttgtcccta agttagacgc ctatgagctt catatgaggg taggagacga gcgctgtaaa
    10441 attggtagct atgattttga aaagtttgca gccgttatca gtcactttaa gtttgtggcg
    10501 ggtatgaatg tgggagaaaa aagacgtagt caactgggtt cctgtgatta tgcctatgac
    10561 cagaagatgg cgtctctacg tttatctact gtaggcgatt atcggggaca tgagagtttg
    10621 gttatccgtt tgttgcacga tgaggagcag gacttgcatt tttggtttca ggatattgaa
    10681 gaattaggca agcagtacag gcaacgggga ctctatcttt ttgctggccc ggttgggagt
    10741 ggtaagacga ccttgatgca tgaattgtcc aagtcactct ttaaaggaca gcaagttatg
    10801 tccatcgaag atcctgtcga aatcaagcag gacgacatgc ttcagttgca gttgaacgaa
    10861 gcaatcggcc taacctatga aaatctaatc aaactttcct tgcgtcatcg accagatctc
    10921 ttgattatcg gagaaattcg tgacatcgag acggcgcgtg cagtggtcag agctagtttg
    10981 acaggtgcga cagtcttttc aaccattcac gccaagagta tccgaggtgt ttatgagcgt
    11041 ctgctggagt tgggtgtgag tgaagaagaa ttggcagttg ttctgcaagg agtctgctac
    11101 cagagattaa tcgggggagg aggaatcgtt gactttgcaa acagagatta tcaagaacac
    11161 caagcagcca agtggaatga gcaaattgac cagcttctta aagatggaca tatcacaagt
    11221 cttcaggctg agacggaaaa aattagctac agctaagcaa aaaaatatca tcaccctatt
    11281 taacaatctc ttttctagcg gttttcatct ggtggagact atctcctttt tagataggag
    11341 ttccttgttg gacaagcagt gtgtgaccca gatgcgtaca ggcttgtctc aggggaaatc
    11401 attctcagaa atgatggaaa gtttgggatg ttcaagtacc attgtcactc agttatctct
    11461 agctgaagtt catggcaatc ttcacctgag tttgggaaag atagaagaat atctagacaa
    11521 tctggccaag gtcaagaaaa agttaattga agtagcgacc tatcctttga ttttgctggg
    11581 ttttcttctc ttaattatgc tggggctacg gaattacctg ctcccacaac tggatagtag
    11641 caatattgcc acccgaatta tcggtaatct gccacaaatt tttctaggca tggtagggct
    11701 tgtttccgtg cttgcccttt tagcactaac tttttataaa agaagttcta agatgagtgt
    11761 cttttctatc ttagcacgcc ttccctttat tggaatcttt gtgcagacct acttgacagc
    11821 ctattatgca cgtgaatggg ggaatatgat ttcacaggga atggagctga cgcagatttt
    11881 tcaaatgatg caggaacaag gttcccagct ctttaaagaa atcggtcaag atctggctca
    11941 aaccctgaaa aatggccgtg aattttctca gacgatagga acctatcctt tctttaggaa
    12001 ggaattgagt ctcatcatag agtatgggga agttaagtcc aagctgggta gtgagttgga
    12061 aatctatgct gaaaaaactt gggaagcctt ttttacccga gtcaaccgta ccatgaattt
    12121 ggtgcagcca ctggttttta tctttgtggc actgattatc gttttacttt atgcggcaat
    12181 gctcatgccc atgtatcaaa atatggaggt aaatttttaa aatgaaaaaa atgatgacat
    12241 tcttgaaaaa agctaaggtt aaagctttta cattgattga gatgttggtg gtcttgctga
    12301 ttatcagcgt gcttttcttg ctctttgtac ctaatctgac caagcaaaaa gaagcagtca
    12361 atgacaaagg aaaagcagct gttgttaagg tggtggaaag ccaggcagaa ctttatagct
    12421 tagaaaagaa tgaagatgct agcctaagaa agttacaagc agatgggcgc atcacggaag
    12481 aacaggttaa agcttataat gaatactata ctaaaaatgg aggggcaaat cgtaaagtca
    12541 atgattaagg cctttaccat gctggaaagt ctcttggttt tgggacttgt gagtatcctt
    12601 gccttgggct tatccggctc tgtccagtcc acttttgcag cagtagagga gcagattttc
    12661 tttatggagt ttgaagaact ctatcgggaa acccaaaaac gcagtgtagc cagtcagcaa
    12721 aagactagtc taaatttaga tgggcagacg cttagcaatg gcagtcaaaa gttgacagtt
    12781 cctaaaggaa ttcaggcacc atcaggccaa agtattacat ttgaccgagc tgggggcaat
    12841 tcgtccctgg ctaaggttga atttcagacc agtaaaggag cgattcgcta tcaattatat
    12901 ctaggaaatg gaaaaattaa acgcattaag gaaacaaaaa attagggcag tgattttact
    12961 ggaagcagta gtcgctctag ctatctttgc cagcattgcg accctccttt tgggacaaat
    13021 tcaaaaaaat aggcaagagg aagcaaaaat cttgcaaaag gaagaagtct tgagggtagc
    13081 taagatggcc ttgcagacag gtcaaaatca ggtaaacata aacggagttg agattcaggt
    13141 gttttctagc gaaaagggat tggaggtcta ccatggttca gaacagttgt tggcaatcaa
    13201 agagccataa ggtcaaggct tttaccttgt tagaatccct gcttgccctg attgtcatca
    13261 gtgggggctt actccttttt caagctatga gtcagctcct catttcagaa gttcgctacc
    13321 agcaacaaag cgagcaaaag gagtggctct tgtttgtgga ccaacttgag gcagaattag
    13381 accgttcgca gttcgaaaaa gtagaaggca atcgcctata catgaagcaa gatggcaagg
    13441 acatcgccat cggtaagtca aagtcagacg attttcgtaa aaccgatgct agtggacggg
    13501 ggtatcagcc tatggtttat ggcctcaaat cagctcagat tacagaggac aatcaactgg
    13561 ttcattttcg tttccagttt caaaaaggct tagaaaggga gttcatctat cgtgtggaaa
    13621 aagaagaaag ttaaggcagg tgttctcctc tacgcagtca ccatagcagc catctttagt
    13681 cttttgttgc aattttattt gaaccgacaa atcgcccact atcaagacta tgctttaaat
    13741 aaagaaaaat tggttgcttt tgccatggct aaacgaacca aggataaagc cgagcaagaa
    13801 agtggggaac aggtttttaa tctaggtcag gtaagctatc aaaacaagaa aacaagcttg
    13861 gtgacgactg ttcgtacgtc taagagccaa tatgagtttc tgtttccttc agtcaaaatc
    13921 aaagaagaga aaagagataa aaaggaagag gtagcgaccg attcaagcga aaaagcggag
    13981 aaaaaaaatc agaagagaag cctgaaaaga aagagaattc ctagtcaatt caactataat
    14041 gcgttgaatc cagaatagtc cactgtagtt tctagaaaat tgctggaaat ggatgttaag
    14101 ctccaattca tttgtttata tcttatttca gtttactata ctttgtgcta aattaaagat
    14161 atgaaacatg attttaacca caaagcagaa actttcgatt cccctaaaaa tatcttcctc
    14221 gcaaacttgg tatgtcaagc agccgagaaa cagattgatc ttctatcaga caaagaaatt
    14281 ttagatttcg gtggtgacac gggtctatta gccttgcccc tagcccctag ccaagcaggc
    14341 taagtcagtc actcttgtag acatttctga gaaaatgttg gagtaagctc gtttgaaagc
    14401 ggagcagcaa gcaatcaaga atatccagtt tttggagcaa gatttaccga aaaatccctt
    14461 ggagaaagag tttgattgcc ttgctgttag tcggcttctt catcatatgc ctgatttgga
    14521 tgcggatctc tcactgtttc atcaacattt gaaggaagat aggaaactca tcattgctga
    14581 ttttaccaag acagaagcta atcatcatgg atttgattta gctgaactgg aaaacaagct
    14641 aattgagcat ggtttttcat ctgtgcatag tcagattctc tatagcgctg aagacctgtt
    14701 tcaagggaat cactcagaat tctttttaac agtatcccaa aaatcactcg cctagtcagg
    14761 gagtgatttt tctataagga tggaaaaaag aagggaaatt tgataagata ggaatatgga
    14821 ttttgaaaaa attgaacaag cttatatcta tttactagag aatgtccaag tcatccaaag
    14881 tgatttggcg accaactttt atgacgcctt ggtggagcaa aatagcatct atctggatgg
    14941 tgaaactgag ctaaaccagg tcaaagacaa caatcaggcc cttaagcgtt tagcactacg
    15001 caaagaagaa tggctcaaga cctaccagtt tctcttgatg aaggctgggc aaacagaacc
    15061 cttgcaggcc aatcaccagt ttacgccaga tgctattgcc ttacttttgg tatttattgt
    15121 ggaagagttg tttacagagg aggaaattac tatcctcgaa atgggttctg ggatgggaat
    15181 tctaggcgct actttcttga cctcgcttga taaaaaggtg gattacttgg gaatggaagt
    15241 ggatgatttg ctgattgatc tggcagctag catggcagat gtaattggtt tgcaggctgg
    15301 ctttgtccaa ggagatgccg ttcgcccaca aatgctcaaa gaaagcgatg tggtcatcag
    15361 tgacttgcct gtcggctatt atcctgatga tgccgttgcg tcgcgtcatc aagttgcttc
    15421 tagccaagaa catacttacg cccatcactt gctcatggaa caagggttta agtaccttaa
    15481 gtcagatgga tatgctattt ttctagctcc gagtgatttg ttgaccagtc ctcaaagtga
    15541 tttgttgaaa gtctggttga aagaggaggc aagtctggtt gctatgatta gtttacctga
    15601 aaatctcttt gctaatgcta aacaatctaa gactattttt atcctacaga agaaaagtga
    15661 aatagcagtg gagccttttg tttatccact tgctagcttg caagatgcaa gtgttttaat
    15721 gaaatttaaa gaaaattttc aaaaatggac tcaaggtact gaaatataaa atagattttg
    15781 ttataatagt tgaaaacgct taaaaagggg tatcatgtta tgacaaaaac aattgcaatc
    15841 aatgcaggaa gttcaagttt gaaatggcaa ttatacttaa tgccagagga aaaagtgtta
    15901 gccaaaggtt tgattgaacg tatcggtttg aaagattcaa tttcaactgt aaaatttgac
    15961 ggccgttctg aacaacaaat tttggatatt gaaaatcata cacaagccgt taaaatttta
    16021 ttggatgact tgattcgttt cgatattatc aaggcttatg acgagattac aggtgttgga
    16081 catcgtgttg ttgctggtgg agaatatttc aaagaatcaa cagttgttga gggagatgtt
    16141 ttagaaaaag ttgaagagtt gagtttgttg gctcctctac acaacccggc caatgcagca
    16201 ggtgttcgtg ccttcaagga attgttgcca gacattacca gtgtagttgt ttttgatact
    16261 tccttccaca caagtatgcc agagaaagct tatcgctacc ctctaccaac aaaatattac
    16321 acagaaaaca aggttcgtaa atacggtgct catggtacaa gtcaccagtt tgtagcagga
    16381 gaagctgcaa aactcttggg acgtccatta gaagacttga agttaattac ctgtcatatt
    16441 ggtaacggag gctcaattac agctgtgaaa gccggcaaat ctgtagacac ttctatgggg
    16501 ttcactcctc ttggtggtat tatgatggga acgcgtacag gggatattga tccagctatc
    16561 attccttatt taatgcaata tacagaggat tttaacacac cagaagatat cagtcgtgtt
    16621 cttaaccgtg aatcaggtct tttgggagtt tctgctaatt ctagcgatat gcgtgatata
    16681 gaagcagctg tagcagaagg gaatcacgag gctagcttgg cttatgaaat gtatgttgac
    16741 cgtatccaaa aacatatcgg tcagtacctt gcagtgctaa atggagcaga tgtcattgtt
    16801 ttcacagcag gtgtcggtga aaatgcagag agtttccgtc gtgatgtaat ctcagggatt
    16861 tcgtggtttg gttgtgatgt tgatgatgaa aagaatgtct ttggcgttac aggagacatc
    16921 tcaacagagg cagctaaaat ccgtgtcttg gttattccaa cagatgaaga attagtcatt
    16981 gcccgtgacg ttgaacgctt gaaaaaataa gtgaaactaa aaaaatattc aatacaagga
    17041 gttgggaaag ttatttttcc agcttctttt tctgatgaaa ttgtccaaaa ccttgctatg
    17101 attggctttt ttgaaaaata tggtataata gtagtaattt aatagatgga gttgagtttt
    17161 gaagaaaaac tttcgtgtaa aaagagagaa agattttaag gcgattttca aggaggggac
    17221 aagttttgct aatcgcaaat ttgtggtcta ccaattagaa aaccagaaaa accattttcg
    17281 agtaggtcta tcagttagca aaaaactggg gaatgccgtc actagaaatc aaattaagcg
    17341 acggattcgg catattatcc agaatgcaaa agggagtctg gtagaagatg tcgactttgt
    17401 tgtcattgct cgaaaaggag tcgaaacctt gggatacgca gagatggaga aaaatctact
    17461 ccatgtatta aaattatcaa agatttaccg ggaaggaaat gggagtgaaa aagaaactaa
    17521 agttgactag tttgctagga ctgtctctgt taatcatgac agcctgtgcg actaatgggg
    17581 taactagcga tattacagcc gaatcggctg atttttggag taaattggtt tacttctttg
    17641 cggaaatcat tcgcttttta tcgtttgata ttagtatcgg agtggggatt attctcttta
    17701 cggtcttgat tcgtacagtc ctcttgccag tctttcaggt gcaaatggtg gcttctagga
    17761 aaatgcagga agctcagcca cgcattaagg cgcttcgaga acaatatcca ggtcgagata
    17821 tggaaagcag aaccaaacta gagcaggaaa tgcgtaaagt atttaaagaa atgggtgtca
    17881 gacagtcaga ctctctttgg ccgattttga ttcagatgcc ggttattttg gccctgttcc
    17941 aagccctatc aagagttgac tttttaaaga caggtcattt cttatggatt aaccttggta
    18001 gtgtggatac aacccttgtt cttccgattt tagcagcagt attcaccttt ttaagtactt
    18061 ggttgtccaa caaagctttg tctgagcgaa atggcgctac gactgcgatg atgtatggga
    18121 ttccagtctt gatttttatc tttgcagttt atgcgccagg tggagtcgcc ctatactgga
    18181 cagtgtctaa tgcttatcaa gtcttgcaaa cctatttctt gaataatcca ttcaagatta
    18241 tcgcagagcg cgaggccgta gtacaggcac aaaaagattt ggaaaataga aaaagaaaag
    18301 ccaagaaaaa ggctcagaaa acgaaataaa taaggaggaa tctggtaatg gtagtattta
    18361 caggttcaac tgttgaagaa gcaatccaga aaggattgaa agaattagat attccaagaa
    18421 tgaaggctca tatcaaagtc atttctaggg agaaaaaagg ctttcttggt ctatttggta
    18481 aaaaaccagc ccaagtggat attgaagcga ttagtgaaac gactgttgtc aaagcaaatc
    18541 aacaggtagt aaaaggcgtt ccgaaaaaaa tcaatgattt gaacgagcct gtgaagacgg
    18601 ttagtgaaga aaccgttgac cttggtcatg tagttgatgc tattaaaaaa atagaggaag
    18661 aaggtcaagg tatttctgat gaagtcaagg ctgaaatctt aaaacatgaa agacatgcca
    18721 gcactatctt agaagaaact ggtcacattg agattttaaa tgaacttcaa atcgaggaag
    18781 cgatgaggga agaagcaggc gctgatgacc ttgaaactga gcaagaccaa gctgaaagtc
    18841 aagaactaga agacttgggc ttgaaagttg aaacgaactt tgatattgaa caagtagcta
    18901 cggaagtaat ggcttatgtt caaacgatta ttgatgacat ggatgttgag gctacacttt
    18961 caaatgatta taaccgtcgt agcatcaatt tgcaaattga tactaacgaa ccaggtcgta
    19021 ttatcggcta ccatggtaaa gtcttgaagg ccttgcaact gttggctcaa aattatcttt
    19081 acaactgcta ttcaagaacc ttctatatca ctattaatgt caatgattat gttgaacacc
    19141 gtgcagaagt cttgcagacc tatgcgcaaa aattggcgat tcgtgtttta gaagaaggac
    19201 gtagtcatca aacagatcca atgtcgaata gtgaacgcaa gattatccac cgtattattt
    19261 cacgtatgga tggcgtgacc agttactctg aaggtgatga gccaaatcgc tatgtcgttg
    19321 tagatacaga ataagtaaaa tcagggttga cctgattttt tgctagctag aggaggttaa
    19381 actgatgttg aataagataa gagactattt agactttgct ggtttgcagt accgtaatcc
    19441 tgataaagcg ggagcagagc gagagaagat gctggcattc cgccacaaag gacaagaggc
    19501 ccgaaaggct tttacagaac tggccaaagc ctttcaagca agccatccag aatggcaact
    19561 ccaacagact agtcagtgga tgaatcaggc ccagcgtttg agaccacatt tttgggttta
    19621 tctacagaga gacggacaag tgacagaacc tatgatggcc ttacgtttgt atgggacatc
    19681 tactgacttt ggaatttctt tggaagtcag tttcatcgaa cgtaagaagg atgagcaaac
    19741 actgggcaag caggccaaag ttttagacat tccaaccgtt aaagggattt attatctaac
    19801 ctactctaat ggtcaaagtc aacggtggga ggcgaatgaa gaaaagcgtc gtactttacg
    19861 cgagaaggtg agaagtcaag aagttcgaaa agttttagtg aaggtagatg ttcctatgac
    19921 agaaaattcg tctgaagaag aaatcgtaga aggcttattg aagtcttatt ctaaaattct
    19981 tccctattat ctagctacga gaaaataaga taatttgtaa aacatcataa atcatacagt
    20041 ccaagagtga acagtccgct gtgtaattct tggtcttttt gtttgcgctt tcgcattata
    20101 taataaactt acaaaaacaa ttcaaaagga gaacaattat ggaagtcgtt tcaagtgttc
    20161 taaattggtt ttctagcaat attttgcaga atcccgcatt tttcgtaggt ttattggtgt
    20221 tgataggata tgcacttttg aaaaaacctg cccatgacgt tttttcaggg tttgttaaag
    20281 caacagtagg gtatatgttg cttaacgtgg gtgctggtgg tttggttaca acctttcgtc
    20341 caatcttagc agctcttaac tacaaattcc aaattggtgc agcggttatc gacccttact
    20401 ttggacttgc tgcagcaaac aacaaaattg cagcagagtt tccagatttt gttggaactg
    20461 caactacagc tctattgatt ggttttggaa taaatatctt gctcgtagct cttcgaaaga
    20521 ttacgaaggt aagaaccctc tttattactg gtcacatcat ggtacaacaa gctgcaacag
    20581 tatctcttat ggttctattc ttagtaccac aattgcgcaa tgcttacggt acagcagcga
    20641 ttggtatcat ctgtggactt tactgggcag ttagttcaaa tatgactgtt gaggcaactc
    20701 aacgcttgac tggtggtggc ggatttgcga ttggtcacca acagcaattt gcaatctggt
    20761 ttgtagataa agtagcagga cgctttggta agaaagaaga aagtttagac aatcttaaat
    20821 tacctaagtt cctctcaatc ttccacgata cagttgttgc atctgctacc ttgatgctcg
    20881 tattcttcgg agccattctt ttaatcttgg gtccagacat tatgtctaat aaagaagtca
    20941 tcacttcagg aactctattc aatcctgcta aacaagattt ctttatgtac attatccaaa
    21001 cagcctttac cttctcagtt tacttgttcg ttttgatgca aggtgtccga atgttcgtat
    21061 ctgagttgac aaacgccttc caaggtattt caaacaaatt gttgccaggt tcattcccag
    21121 cggttgacgt tgcagcttct tatggatttg gttctccaaa tgctgtcttg tcaggattta
    21181 cctttggttt gattggtcaa ttgattacaa ttgtcttgct catcgtcttt aaaaatccga
    21241 ttcttattat tacaggattt gtaccagtgt tctttgacaa tgcagccatt gcggtctacg
    21301 ctgataaacg cggcggatgg aaagcggctg ttatcctttc ctttatatca ggtgtccttc
    21361 aagttgctct aggagctctt tgtgtggccc ttctcgattt ggcatcttat ggtggctacc
    21421 atggaaatat cgactttgaa ttcccatggc ttggatttgg atatatcttc aaataccttg
    21481 gtattgttgg ttatgtactt gtgtgtctct tcttgcttgt tattcctcaa cttcaatttg
    21541 ccaaagcaaa agataaagag aaatattaca acggtgaagt tcaagaagaa gcttagtatc
    21601 tagaaaagga gaaataaaat ggttaaagta ttagcagcgt gcggaaatgg aatgggttca
    21661 tcaatggtta tcaagatgaa ggttgaaaat gctctccgta agcttaatca aacagatttt
    21721 acagtcaatt catgcagtgt cggtgaagct aaaggtttag cagtaggata tgacatcgta
    21781 atcgcttctc ttcatttgat tcaagaattg gaagggcgaa ctaatgggaa gttaattggg
    21841 cttgataact tgatggatga taaagaaatc accgaaaaac tcagtcaagc actacagtaa
    21901 aaggttggag ggggctggac agaaactgag agttatcgtt tctgtccttc tccctcttta
    21961 aataaaggag gcagatatga atttaaaaca agctttaatt gacaatgact cgatccgact
    22021 aggtttagag gctaacaatt ggaaagaagc agtcaaggta gcagtagatc ccttaattga
    22081 aagtggggca attttgccag agtattacga tgctatcatt gaatcgactg aagagtatgg
    22141 gccttactat atcttgatgc caggtatggc tatgccccac gctagacctg aagctggtgt
    22201 gcaaagtgat gccttttcat tgattacctt acaaaatcct gttgtatttt cagatgggaa
    22261 agaggtatct gttttgttgg cactagcagc aacaagttca aaaattcaca caagtgtagc
    22321 cattccacaa attattgccc tgtttgaatt agaagattct attgcacgtt tacaggcttg
    22381 ccagactaaa gaagatgtct tggctatgat tgaagaatct aaggatagcc cttatctcga
    22441 aggattggat ttggaaagtt agaaagagga ataaagaaat gacaaaaaga atacctaatt
    22501 tacaagttgc attagaccat tcagacttgc aaggagcgat taaagcagct gtttctgttg
    22561 gtcaggaagt agatattatc gaagctggaa ctgtttgctt gcttcaagtt ggaagtgaac
    22621 tggctgaagt cttgcgtagc cttttcccag ataagattat tgtggcagac acaaaatgtg
    22681 ctgatgctgg tggaacagtt gctaaaaata atgcggttcg tggagcagac tggatgactt
    22741 gtatctgttg tgcaaccatc cctactatgg aagcagctct aaaggctatc aagactgaac
    22801 gaggagaacg aggcgaaatc cagatcgagc tttatggcga ttggactttt gaacaagctc
    22861 agctttggct agatgcaggt atctcacaag ctatttatca ccaatctcgt gatgctcttc
    22921 ttgctggtga aacttggggt gaaaaagacc ttaataaggt taaaaaactc attgatatgg
    22981 gcttccgtgt atctgtaaca ggtggtctag atgtagatac tctcaaactc tttgaaggtg
    23041 ttgatatctt tacctttatc gcaggtcgtg gaattacaga ggctgcggat ccagcaggag
    23101 cagcgcgtgc cttcaaggat gaaatcaaac gaatttgggg gtaaatcatg gtacgtccaa
    23161 ttggaattta tgaaaaggca accccaacac actttacttg gctagaacgt ttaaattttg
    23221 ccaaggagtt aggctttgat tttatcgaga tgtctattga cgaacgtgac gagcgtttag
    23281 caagacttga ctggagtaag gaagaacgct tggaagttgt caaagaaatc tatgaaactg
    23341 gtgttcgtat tccttctatc tgtttttcag gccatcgtcg ctacccattg ggatcaaaag
    23401 attcagttct agaggaaaaa tctctagaac tcatgaaaaa atgtatcgaa ttagctcaag
    23461 acttgggagt tcgtacgatt caattagctg gttacgatgt ttactatgag gaaaagtcac
    23521 cccagacacg ccaacgtttt atcaaaaatt tgagaaaagc ctgtgactgg gctgaagaag
    23581 ctcaggtggt acttgctatt gaaattatgg atgatccttt catcagtagc atcgaaaaat
    23641 atttggctat agaaaaagag attgactctc ccttcctctt tgtatatcca gatattggta
    23701 atgtgtctgc atggcataat gatatctata gtgagtttta tcttggtcat catgccatcg
    23761 cagctctcca tctcaaggat acttatgcag tgacagaaag ttcaaagggc cagttccgag
    23821 atgtaccttt cgggcaaggt tgtgtcaaat gggaagaagc tttcgatatt ttaaaggaaa
    23881 ccaattataa tggacctttc ctaatcgaaa tgtggtctga aaattgtgaa acagtagaag
    23941 aaacacgcgc agccattcaa gaggcgcaag cttttctcta tccactcatt aagaaagcag
    24001 gtttgatgta agatgaatca agtaatcaat gctatgcgta aacgagtctg tgatgccaat
    24061 caatcattgc caaaacatgg acttgtcaaa tttacctggg ggaatgtatc tgaagtcaat
    24121 cgcgaactcg gtgtcattgt tatcaaacca tcaggcgtgg attatgacga attgacacct
    24181 gaaaacatgg tagtgactga tctagatggt aagatcctag aaggggattt aagaccatct
    24241 tccgacctcc caactcatgt gcaattatat aaggcttggt cagaaattgg tagtgtggtt
    24301 cacacccatt cgacagaagc tgttgcttgg gctcaggcag gtcgtgatat tcctttctac
    24361 ggaacaaccc atgcagatta tttctacggt tcaattcctt gcgcccgtag tttgaccaag
    24421 gacgaagtag aagtggccta tgaaaaagat actggcctgg ttatcgtaga agagtttgaa
    24481 catcgcggac ttaacccggt tgaagtacca ggaattgttg tacgcaatca cggtccattc
    24541 acctggggca aaaatccaga gaatgctgtt tatcactctg tcgtactaga ggaagtatca
    24601 aagatgaatc gctttacaga acaaatcaat ccaagagttg gacctgctcc ccagtacata
    24661 ctagaaaaac actaccaacg taaacatgga ccaaatgctt attatggtca aaagtaagaa
    24721 cgatgaagga ggagaaaaag ataaatttag ctcctctttt tacatttgat ttttattgag
    24781 agtaaagttg gagttgaagt aattttaaaa gattttttag aaatagcgct tgatatatat
    24841 atggtaaaat aaaaagaatt gctgtgatat caatagattt gggggatttt ttaatatggt
    24901 actggataag gcaagttgtg atttgcttca atatttgatg gatcaagaaa cgtccaaaac
    24961 gattatggcg atttcgaaag atttgaaaga gtcaagaagg aaaatttatt atcacattga
    25021 caaaatcaat gctgctctgg gtgacgaggc gcttcacatc attagtattc cacgaattgg
    25081 tattcactta acggaagagc agagagatgc ttgttgtaaa ctattatcgg aagtagattc
    25141 gtacgattat atcatgagtg cgcatgaacg tatgatgata atgttactat ggataggtat
    25201 ttctaaagaa cgtattacga ttgaaaaatt gatagagtta acagaggtat ctaggaatac
    25261 tgttctcaat gatttgaata gtattcgtta tcaactaact ttggaacaat atcaggtgat
    25321 cttgcaagtg agcaagtcac agggatacca ccttcatgcc caccctctta ataaaattca
    25381 gtatcttcaa tcgcttctat atcatatttt tatggaagaa aatgccactt ttgtatctat
    25441 tttagaagat aagatgaaag agaggttaga tgatgagtgt ttgctttctg ttgaaatgaa
    25501 ccaatttttt aaggaacagg ttcctttagt tgaacaagat ttagggaaga aaataaatca
    25561 tcatgaaata acttttatgt tgcaggttct accttatttg ctgttaagct gtcataatgt
    25621 tgaacagtat caagaaagac atcaggatat agagaaagaa ttttctttga taagaaaaag
    25681 aatagagtat caggtgtcta agaaattagg agaacggttg tttcaaaagt ttgaaatttc
    25741 tttgtcagga cttgaagttt ctcttgtagc tgttctcctc ctctcctatc gtaaagattt
    25801 ggatattcat gcagaaagtg atgattttcg gcaattaaaa cttgctttag aagaatttat
    25861 ctggtatttt gaatcacaaa tccgaatgga gattgagaac aaggatgatt tgttacgaaa
    25921 tttgatgatc cactgtaaag ccttgttatt tagaaagact tacggtattt tttctaaaaa
    25981 tcctctaaca aaacaaattc gatccaagta tggagaatta tttttagtca ctagaaaatc
    26041 tgcggaaatt ttagaaggag catggtttat tcggctaaca gacgatgata ttgcctattt
    26101 gacgattcat attggaggat ttttaaagta tacaccatcg tctcaaaaaa atatgaaaaa
    26161 agtttatctc gtttgtgatg aaggtgttgc ggtttcgaga cttttgctga aacaatgcaa
    26221 actttatttt ccaaatgagc aaattgacac tgtatttaca acagaacaat ttaagagtgt
    26281 ggaagatatt gcacaagttg atgtagtgat tactactaat gatgatttgg atagcagatt
    26341 tccgatttta agggttaatc ctatccttga agcagaagat attttgaaaa tgctagacta
    26401 tcttaaacac aatatatttc gtaataagag caaaagtttc agtgaaaatc tttctagtct
    26461 tatttcgtct tatattgtag acagcaagtt ggctagtaag ttccaagaag aggttcaaac
    26521 acttataaat caagaaatag tagttcaagc ttttttggaa gatatttgaa ggacagtcca
    26581 atgatgaaca caaacctgtg tttttcttgg tcttttttag tgttttgaag ggtggtatac
    26641 taatctcaaa gataacaatt atatccaaag gaggcaacat atgccaaacg tcaaagaaat
    26701 tacaagagag tcatggattt tagccacttt cccagagtgg ggaacatggt tgaacgaaga
    26761 aatcgaagaa gaagtcgtac ctgaaggcaa ctttgccatg tggtggctag gcaactgtgg
    26821 tacttggatt aagacaccag ctggtgctaa cgttgtcatg gacctttggt caaaccgtgg
    26881 aaaatcaacc aaaaaagtga aagatatggt tcgtgggcac caaatggcaa atatggcagg
    26941 tgttcgtaaa ttgcaaccaa acttgcgtgt tcagccaatg gttatcgatc catttgctat
    27001 caacgaacta gactattact tagtttcaca cttccacagt gatcatatcg acccatacac
    27061 agctgcagca attctcaaca atcctaagtt agagcatgtt aagtttatcg gtccttacca
    27121 ctgtggacga atctgggaag gatggggggt tccaaaagaa cgtatcatcg ttgttaaacc
    27181 aggtgacact atcgaattaa aagatatgaa gattcatgca gtagaatcat ttgaccgtac
    27241 ttgcttggta actctcccag tgaacggtgc tgatgagaca ggcggtgaac ttgctggctt
    27301 ggctgttaca gatgaagaaa tggctcaaaa ggctgttaac tatatctttg aaacaccagg
    27361 tggaaccatc tatcatggtg cagattctca cttctcaaac tattttgcaa aacatggtaa
    27421 agactttaaa attgatgttg ctttgaataa ctatggtgaa aatccggtag gtatccaaga
    27481 caaaatgaca tctatcgacc ttcttcgtat ggcagaaaat ctgcgtacca aagtcattat
    27541 cccagttcac tatgatatct ggtctaactt catggcttct actaatgaga ttctagaact
    27601 ttggaaaatg cgaaaagatc gcttgcaata cgatttccat ccatttatct gggaagttgg
    27661 cggtaagtac acttatcctc aagatcaaca cttagtagaa taccatcatc cacgtggttt
    27721 tgatgattgt tttgaacaag actctaacat tcaatttaaa gctttgctat aatataaaaa
    27781 tattctttgg aggttatccg tatgttgcat gatacggata attttcatat aatagtaaaa
    27841 tagaatgtgt gattcaataa tcacctcaaa tagaaaggaa attctatgtc aaatctatct
    27901 gttaatgcaa ttcgttttct aggtattgac gccattaata aagccaactc aggtcatcca
    27961 ggtgtggtta tgggagcggc tccgatggct tacagcctct ttacaaaaca acttcatatc
    28021 aatccagctc aaccaaactg gattaaccgc gaccgcttta ttctttcagc aggtcatggt
    28081 tcaatgctcc tttatgctct tcttcacctt tctggttttg aagatgtcag catggatgag
    28141 attaagagtt tccgtcaatg gggttcaaaa acaccaggtc acccagaatt tggtcatacg
    28201 gcagggattg atgctacgac aggtcctcta gggcaaggga tttcaactgc tactggtttt
    28261 gcccaagcag aacgtttctt ggcagccaaa tataaccgtg aaggctacaa tatctttgac
    28321 cactatactt acgttatctg tggagacgga gacttgatgg aaggtgtctc aagcgaggca
    28381 gcttcatacg caggtttgca aaaacttgat aagttggttg ttctttatga ttcaaatgat
    28441 atcaacttgg atggtgagac aaaggattcc tttacagaaa gtgttcgtga ccgttacaat
    28501 gcctacggtt ggcatactgc cttggttgaa aatggaacag acttggaagc catccatgct
    28561 gctatcgaaa cagcaaaagc ttcaggcaag ccatctttga ttgaagtgaa gacggttatt
    28621 ggatacggtt ctccaaacaa acaaggaact aatgctgtac acggcgcccc tcttggagca
    28681 gatgaaactg catcaactcg tcaagccctc ggttgggact acgaaccatt tgaaattcca
    28741 gaacaagtat atgctgattt caaagaacat gttgcagacc gtggcgcatc agcttatcaa
    28801 gcttggacta aattagttgc agattataaa gaagctcatc cagaactggc tgcagaagta
    28861 gaagccatca tcgacggacg tgatccagtc gaagtgactc cagcagactt cccagcttta
    28921 gaaaatggtt tttctcaagc aactcgtaat tcaagtcaag atgccttgaa tgttgtggca
    28981 gctaaattac caaccttcct aggtggatca gctgaccttg ctcactcaaa catgacttat
    29041 atcaagacgg atggacttca agacgatacc aatcgcttga atcgtaacat tcagtttggt
    29101 gttcgtgaat ttgcaatggg aacaatcttg aacgggatgg cccttcatgg tggacttcgt
    29161 gtatacggtg gaactttctt cgtcttctct gactatgtga aggcagctgt ccgcttgtca
    29221 gccttacaag gacttcctgt gacttatgtc tttacccatg attcaatcgc a
//
LOCUS       DBMVGT010000020        26981 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.020, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000020 DBMVGT010000000
VERSION     DBMVGT010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 26981)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26981)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26981
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.020"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(53..1201)
                     /locus_tag="AC0DU4_000958"
     CDS             complement(53..1201)
                     /locus_tag="AC0DU4_000958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000876726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009009 - site-specific recombinase
                     activity [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HIN4236937.1"
                     /translation="MKYNKTKYPNIYYYETAKGKRYYVRRSFFFRGKKREKSKSGFTT
                     LPQARAALVELEQQIQEQELGINTNLTLDQYWDIYSEKRLSTGRWNDTSYYLNDNLYN
                     NHIKAKFGSILLKNLDRNEYELFIAEKLQNHTRYTVQTLNSSFMALLNDAVKNGNLLS
                     NRLKGVFIGQSDIPAANKKVTLKEFKTWIAKAEEIMPKQFYALTYLTIFGLRRGEVFG
                     LRPMDITQNDSGRAILHLRDSRSNQTLKGKGGLKTKDSERYVCLDDIGTDLIYYLIAE
                     ASKIKRKLGIIKEQHKDYITINEKGGLINPNQLNRNFNLVNEATGLHVTPHMMRHFFT
                     TQSIIAGVPLEQLSQALGHTKVYMTDRYNQVEDELAEATTDLFLSHIR"
     gene            complement(1387..2310)
                     /locus_tag="AC0DU4_000959"
     CDS             complement(1387..2310)
                     /locus_tag="AC0DU4_000959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000122591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004527 - exonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HIN4236938.1"
                     /translation="MSYSYVALDVETANDFRGSVCSIGLVKFKDGNIVDTFYTLINPE
                     EEFDDFNIFIHGITPEDVLDSPTFPEVRKSIVDFIGLDIVVAHFAQFDMGALKDVYQK
                     YELDFDNIEYICSYRLAKVALPGQLNYKLKRLAKNLNIELDHHNALSDARASGLILEY
                     LLSTNSFSDLTAFLKEYRYNKTGLLGQYGFKRKKGYQYKENLIYQPTEEEKAAMNPDH
                     YFYGLYFCFTGKLERMTRKEANKAAALVGGIPEKGVTKHTNILVVGEQDWRVVGTDGL
                     SSKMKKAQTLLEKGQDIEIMTENDFIRLLEE"
     gene            complement(2323..2706)
                     /locus_tag="AC0DU4_000960"
     CDS             complement(2323..2706)
                     /locus_tag="AC0DU4_000960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="HIN4236939.1"
                     /translation="MTEKEIISHFQVRIVDFDGELIPDELGFYEKETNTAFLSNKLSK
                     KERVKVLLHELGHKDHTRSEYQNARLRCENEADRNMIHHLVKDALESLDDPTEFDYLK
                     FMSYYNLKTMTNEVMVKEEYFALME"
     gene            complement(2719..3084)
                     /locus_tag="AC0DU4_000961"
     CDS             complement(2719..3084)
                     /locus_tag="AC0DU4_000961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000492032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4236940.1"
                     /translation="MFSLFEKIKELCQNRGISINSLEETLGYSRNTIYSMKNKKPNAE
                     RLQEIADYFNVSTDYLLGRTDNPAIAGDSKEYTWQGKTLNVEEMASNVMMFGGRELTD
                     EKKKIIQSIIEGYLKEAGD"
     gene            complement(3461..3682)
                     /locus_tag="AC0DU4_000962"
     CDS             complement(3461..3682)
                     /locus_tag="AC0DU4_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000041097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236941.1"
                     /translation="MSKLTKEDVLQVSQEIINDAIPVIKDMLDEVFKEYPIDMEIRKA
                     ILNSVLVAHKLSTETTVSLLTELVNAQEN"
     gene            3801..3947
                     /locus_tag="AC0DU4_000963"
     CDS             3801..3947
                     /locus_tag="AC0DU4_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236942.1"
                     /translation="MEDKIIELADYFISENTTYREAKIACEKLFKQASHEIELRALES
                     ETKK"
     gene            3959..4162
                     /locus_tag="AC0DU4_000964"
     CDS             3959..4162
                     /locus_tag="AC0DU4_000964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HIN4236943.1"
                     /translation="MSKELKIIKAKIKTRLIELDMTQAELAKQVSVASSVISELLKYG
                     KGSESVKEKVADVLGIENPWENS"
     gene            4179..4376
                     /locus_tag="AC0DU4_000965"
     CDS             4179..4376
                     /locus_tag="AC0DU4_000965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001066214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236944.1"
                     /translation="MNNAAQKVTRIDKDAWEIATELANEYGVSICHIISESVRYCAEN
                     AEFKEMDVVVKRLVVGSKVLE"
     gene            4387..4548
                     /locus_tag="AC0DU4_000966"
     CDS             4387..4548
                     /locus_tag="AC0DU4_000966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236945.1"
                     /translation="MNEIVWFYFVVIINLIIGFATYYASKRDRKKRINEYKKIQDDEL
                     ERIRNKFNL"
     gene            complement(4543..4968)
                     /locus_tag="AC0DU4_000967"
     CDS             complement(4543..4968)
                     /locus_tag="AC0DU4_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000456432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236946.1"
                     /translation="MDYQILIQPAISVILAIISGLWSYIASKANNKAEIEKQAKEHSH
                     IVEKLEKEFHYQIDTLKQQHTLELEKVKQAHELRLQELEKVSQIDTETDKAMKMNDLI
                     YKTFTGEVDLDKALKLADKANNHKQKLNKKFIQKTSKKS"
     gene            5022..5732
                     /locus_tag="AC0DU4_000968"
     CDS             5022..5732
                     /locus_tag="AC0DU4_000968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ORF6C domain-containing protein"
                     /protein_id="HIN4236947.1"
                     /translation="MNEIFNFHGQEVRTLTIDDEPWFVGKDVADILGYSKARNAITLH
                     VDEEDALKQGIPTSGGTQDMLIINESGLYSLILSSKLPQAKEFKRWVTSEVLPAIRKQ
                     GGFIREDLDEDAFIALFTGQKKLREQQATMLEDIDYLKSEQPIHPSYAQSLLKKRKAR
                     VVACLGGIDSPAYADKVFAQSVFRQAEIDFKDHFNISRYDLLPKKHADAALAYWMTWE
                     PSTNTKMKIMKLNSFDDV"
     gene            5746..6003
                     /locus_tag="AC0DU4_000969"
     CDS             5746..6003
                     /locus_tag="AC0DU4_000969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HIN4236948.1"
                     /translation="MDNVLLSLSEWIKSIIKDTITRLVEIEKDSDHYPELMDVNTTCE
                     FLGIKYATFSDNYRYLKGFPKELPGKKWSKRAIKEWLSNQI"
     gene            6089..6409
                     /locus_tag="AC0DU4_000970"
     CDS             6089..6409
                     /locus_tag="AC0DU4_000970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236949.1"
                     /translation="MFEPPILDQLMGVGALLLGFAGACRHIKLQEQRKEEERREEQEF
                     ASMIIQGYNHAYERGREAERQEIRKNIRRPFKGFTYDNEPPQGLRPEPLALPEPKQSA
                     IRLL"
     gene            6425..6721
                     /locus_tag="AC0DU4_000971"
     CDS             6425..6721
                     /locus_tag="AC0DU4_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865133.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236950.1"
                     /translation="MEELIESLDNLIMIVKELEGRESTSRHFITIWENDYKNLLLVKE
                     YLTDYEKLAKDYRYVTLKNKLLKIEKMELEGRHIYEDMRMKYRANRRKWGARYV"
     gene            6714..7520
                     /locus_tag="AC0DU4_000972"
     CDS             6714..7520
                     /locus_tag="AC0DU4_000972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001289771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage replisome organizer N-terminal
                     domain-containing protein"
                     /protein_id="HIN4236951.1"
                     /translation="MSEIKWIKITTDIFDDEKICLIDALPDPDAILVIWFKILTLAGK
                     HNSNGLLMMTDKVHYTDEMLATIFRRPLNTVRMAIGVFEQFGMIEIIDGIISLPNWEK
                     HQNVDGMEKIKEQTRNRVAKYRKKQKNLALGNVTGNVTVTDGNALEEDKDKNKNRLDK
                     DKNKKRITTTSSGSEENILELFQSEFRRLLSGFEIEEINHLLNENDVDLVKEALKTAI
                     NSGKPNIKYIGGILRNWQMNNVTTVEQVRQSEKKNKDKKEEQEAKDEWGY"
     gene            7660..8430
                     /locus_tag="AC0DU4_000973"
     CDS             7660..8430
                     /locus_tag="AC0DU4_000973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HIN4236952.1"
                     /translation="MVDNVFEEIALSYRRNTEQQEEFCEKHNIPLIKILRTESVVCRM
                     CESERIHEENQERVNELANAENERERKYYLEKFSLYDEVLKNATLDNFETPTEKEAEK
                     LAFAKRICREWSEGARNNIVLQGEAGTGKSHLAFAMVKVLSEYTKEIAIFINVTDLLM
                     KIKADFSQEEFLVNKIASAKFLVLDDLGMEKDSEWSFTILYNILNKRSNTIITTNLIS
                     ADIQKRYGRPFMSRLMKGVDKDHLMVFNDLTNKRKQYF"
     gene            8445..8639
                     /locus_tag="AC0DU4_000974"
     CDS             8445..8639
                     /locus_tag="AC0DU4_000974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236953.1"
                     /translation="MFILKHGTREDKPFLRSAIVSVTGLDISCSEEKKAMRFISRAAA
                     LQVSKALRGSFGNFYPVEVE"
     gene            8639..8857
                     /locus_tag="AC0DU4_000975"
     CDS             8639..8857
                     /locus_tag="AC0DU4_000975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000891962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236954.1"
                     /translation="MLELYFVYNGHCKFFLGRFDNVDDLIEQMEDHQWAFSAITHPRF
                     QKHIGQRTTRFDYGSKDCYYLATFSGGE"
     gene            9239..9337
                     /locus_tag="AC0DU4_000976"
                     /pseudo
     CDS             9239..9337
                     /locus_tag="AC0DU4_000976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003219228.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
     gene            9351..9518
                     /locus_tag="AC0DU4_000977"
     CDS             9351..9518
                     /locus_tag="AC0DU4_000977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000233204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236955.1"
                     /translation="MVGVTYQEIHLFVEFLKEQYGQGRPDYIEALNDLDGLVEVSYRE
                     AIERFLEDEVR"
     gene            9686..10003
                     /locus_tag="AC0DU4_000978"
     CDS             9686..10003
                     /locus_tag="AC0DU4_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236956.1"
                     /translation="MMEELKKKVNAVYNWTVEDGKPQPPQQDLPQAVKDRVDYFWEMA
                     EDGMTFMGAMECIFADEKPTDYELGATKGWLPKSKEFDDWIGYSPSMAQVVIAVYLIY
                     GGN"
     gene            10005..10079
                     /locus_tag="AC0DU4_000979"
                     /pseudo
     CDS             10005..10079
                     /locus_tag="AC0DU4_000979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041154.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1642 domain-containing protein"
     gene            10256..10657
                     /locus_tag="AC0DU4_000980"
     CDS             10256..10657
                     /locus_tag="AC0DU4_000980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000736386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HIN4236957.1"
                     /translation="MKKLSDEELKTLDRELFKFQNIQRTIDLRRLELETRNPDAQSGP
                     TVGISKPTETIAIRIADDPTLKFLEGFKGIINKLLSNLVDEDMEIFNLRWRYPQLRWE
                     EIAEQKFMSKATIYRRRRIILEQYAILKGEL"
     gene            10845..11387
                     /locus_tag="AC0DU4_000981"
     CDS             10845..11387
                     /locus_tag="AC0DU4_000981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000397549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HIN4236958.1"
                     /translation="MEFVSPIKDNDDIQAMKDYLREWNEMYYMLFITGLNTGLRVGDI
                     LTLKVKDVQGWHIKLRERKTGKQITRRMTKELKKEMRRYVEGKPFHHFLFKSRQGQNK
                     AITRERVYQIIHEAAEELGIDNVGTHTMRKTFGYKYYNKTKDVGTLQKMFNHSSPAIT
                     LRYIGIEQAELDDALRNFVI"
     gene            11764..12084
                     /locus_tag="AC0DU4_000982"
     CDS             11764..12084
                     /locus_tag="AC0DU4_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HNH endonuclease"
                     /protein_id="HIN4236959.1"
                     /translation="MYNKPVRPSLKSKKWEKFRDRIMRKHDYLCQESLRYGISVQAEM
                     VHHIFPVSEYPELEFVEWNCLPLTNKKHNTFHDRVNDRVINQGLYWQKKRKKEFLNFF
                     KNEK"
     gene            12221..12613
                     /locus_tag="AC0DU4_000983"
     CDS             12221..12613
                     /locus_tag="AC0DU4_000983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001118284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="P27 family phage terminase small subunit"
                     /protein_id="HIN4236960.1"
                     /translation="MAKPITAKSIKSKVVKQMKDLGTYRKEFEMIIDIFAGMLYQYQK
                     LAQDYANLGYPVTDTYVNKAGAENERKVPILTAMEILRKDILSYSNQLMMNPKSLGEV
                     VEQEGDSVLTEVLKFKNEIKKKRVSGNG"
     gene            12606..14336
                     /locus_tag="AC0DU4_000984"
     CDS             12606..14336
                     /locus_tag="AC0DU4_000984"
                     /EC_number="3.6.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004519 - endonuclease activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0140657 - ATP-dependent activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="terminase large subunit"
                     /protein_id="HIN4236961.1"
                     /translation="MGNLDKAKEYAQHVLTHREEHCEENILAAERFFRDLENPAFEMD
                     EDMVDFVIHFIENVIVHQQGDDMFAVSIRNKPLLLQPWQHFVVVNLFGFYYKGTNERR
                     FKEALIMLARKNGKTSFTAAIALAYQILDTDSGSKCYIVANSVKQAMEAFGFLRFNVE
                     RWNDKNIRIKDNNQEHSITANFGDEGSFFIQALANDESRLDSLNGNVIILDEAHTMRN
                     SKKHGLMKKTMSAYRNSMLFVISTAGDIPTGFLANRLKYCQKVLKQLVTDDSFFIFIC
                     KANQSADGDVVNYLDENILKMANPSWGVTVSLKALKEEAEQAMNDPQTRNEFFNKTLN
                     IFTNSMNAYFNPDEFIASDSCYDWSLEELARLPIRWYGGADLSRLHDLTAAALYGVYH
                     DGEKDVDICITHAFFPRINAQKKANDDGIPLFGWQSDGWLTMSNTPTVLYDDIVKWFI
                     KMREKGFKIAAVGMDRKFGREFLTKMKQARFKMIDQPQLFYLKSEGFRRIEFKVKNKE
                     FYYLHSDAYEYCVSNVRAIEKVDDAVQYEKLDGDGGTARIDLFDASVFACIQALANLG
                     KGGDVMRFFD"
     gene            14344..14562
                     /locus_tag="AC0DU4_000985"
     CDS             14344..14562
                     /locus_tag="AC0DU4_000985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236962.1"
                     /translation="MNEIVLSEHEINLLINKGRVKVILNGEVVTIRQRHMKNLMAETV
                     KWEKQVIDVSQNIVRNKHFDSLFQNTFR"
     gene            14580..15782
                     /locus_tag="AC0DU4_000986"
     CDS             14580..15782
                     /locus_tag="AC0DU4_000986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000510804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0044423 - virion component [Evidence
                     IEA];
                     GO_function: GO:0005198 - structural molecule activity
                     [Evidence IEA];
                     GO_process: GO:0019068 - virion assembly [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phage portal protein"
                     /protein_id="HIN4236963.1"
                     /translation="MGIFEKFWKRNKPSKPINMLSHSDLGLSNLMDSYVPLARNPDVV
                     TAVNKIADLVSNMTIHLMENTDKGDIRIRDGLARKIDINPCKHMTRKSWIFKIVRDLL
                     LYGDGNSVLHVEYEPVTDYISNLRPFPMREVSFQTDKDSYVISFRGEEYSPDEVVHFV
                     INPDPDILYIGTGFRVTLTDVVQSLNMATKTKKSFMNGKNIPSLIVKVDSSSAELDSE
                     QGRERIAEKYLSTSRVGAPWIVPEALLDIQQVKPLSLTDIALNESVELDKRTVAGLLG
                     VPAFILGVGEFNKTEYNNFVNTTVMSIATTITQTLTRDLLLSSNRYFKLNPRSLFSYN
                     ITELSAVAQQMANSAAMRRNEWRDWLGMAPDPEMEELIVLENFLPQEKLGDQNKLKGG
                     EEENAKAK"
     gene            15766..16341
                     /locus_tag="AC0DU4_000987"
     CDS             15766..16341
                     /locus_tag="AC0DU4_000987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001172113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005198 - structural molecule activity
                     [Evidence IEA];
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_process: GO:0019068 - virion assembly [Evidence IEA];
                     GO_process: GO:0019082 - viral protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HK97 family phage prohead protease"
                     /protein_id="HIN4236964.1"
                     /translation="MQKRNSYRATQFQTREEESGDLVLSGYFIKFDEETELWRGYHEV
                     IKRAGVEKAVTDADIRALFNHDDSLVLGRTGNGTLTLGVDDVGLFGDIIINKDDPQAV
                     GAYARVKRGDVIGCSFGFIPVKIETEEREDGSYLDTVLELEIFEVSPCTFPAYPQTEI
                     AARQKDFESQKRANREALDKRKKEIKEKFKL"
     gene            16338..17504
                     /locus_tag="AC0DU4_000988"
     CDS             16338..17504
                     /locus_tag="AC0DU4_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0044423 - virion component [Evidence
                     IEA];
                     GO_function: GO:0005198 - structural molecule activity
                     [Evidence IEA];
                     GO_process: GO:0019068 - virion assembly [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phage major capsid protein"
                     /protein_id="HIN4236965.1"
                     /translation="MNKALIFGARMRAKATKVVELEETIEELNKRSVVELEKLDRAKN
                     DEEVLAVEKTVDGLQREIEEKEAEKVQLENEIDELDKQIKEQNRKAPTPGKMEERGGK
                     TLGQREAFNHYLRTKEARADGFKSAEGEAIIPVELMTPKEAKQDKTDLTSLVNIVNVK
                     NASGKWSVVKLTDQAMNTVEELEENPELAKPTFTKVNYEIKTRRGHLPVSQEFIDDAD
                     YDVMGLVAKQTKNQERITKNKEIAKVLKTATSKSAAGLDGLKDILNVELKTYYNATIV
                     CTQSMFAALDKIKDKDGRYMLQTDITSPTGYKFAGRVIVVYPDDIIGESKGDLKAFIG
                     DVGEFATLFDRAQTTVKWQDDKIYGQYLATANRFDVVKVDGDAGFYVTYTDAVL"
     gene            17516..17785
                     /locus_tag="AC0DU4_000989"
     CDS             17516..17785
                     /locus_tag="AC0DU4_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236966.1"
                     /translation="MVYKVIRPFKDLRDPKKHCYKVGDNYPRVKHKLDKEFAETLLNG
                     ANSAGSIFLMNVEDKDMSKDDTLTTEVEKEETKVVDGKPEEGDEE"
     gene            17788..18069
                     /locus_tag="AC0DU4_000990"
     CDS             17788..18069
                     /locus_tag="AC0DU4_000990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000371962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236967.1"
                     /translation="MDNVQLLELLKLKLGIATKLRDKPLEKIIEAVKTELEDNLGVLL
                     DLDSSEDQMFVVDFAAFRYEGGVDMPRHLQWRLHNLQIASKKKVKNVES"
     gene            18056..18355
                     /locus_tag="AC0DU4_000991"
     CDS             18056..18355
                     /locus_tag="AC0DU4_000991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000267058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0044423 - virion component [Evidence
                     IEA];
                     GO_function: GO:0005198 - structural molecule activity
                     [Evidence IEA];
                     GO_process: GO:0019068 - virion assembly [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phage head closure protein"
                     /protein_id="HIN4236968.1"
                     /translation="MWNHEIKLISKKITGKDKLLQPISEDVEVTLLCRKKNVTRSEFY
                     QANQAGLKPSLVVEIRNFEYENQEFAKFEGKQYRILKTYPIDSEILELTLTEVLK"
     gene            18352..18699
                     /locus_tag="AC0DU4_000992"
     CDS             18352..18699
                     /locus_tag="AC0DU4_000992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000063887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HK97 gp10 family phage protein"
                     /protein_id="HIN4236969.1"
                     /translation="MSNDLADLIAKELAAYSDEVTEEVDKIAEQVTDETVDELKETSP
                     KRYGKYRRSWKKKKLANGSFVVFNAVASLTHILENGHLSRNGGRVAGIVHIKPAEEKA
                     IQNFEKRIKEIGK"
     gene            18696..19019
                     /locus_tag="AC0DU4_000993"
     CDS             18696..19019
                     /locus_tag="AC0DU4_000993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236970.1"
                     /translation="MKLSDFAAILEQANLPVTYRAFKIGNAPDLPYLVYYESSPVINS
                     ADNTVNHQIKSVTVELAFESKDEDLEERLEELWANHKLFFEVQEETFIETERLYVKSY
                     TVYLY"
     gene            19031..19609
                     /locus_tag="AC0DU4_000994"
     CDS             19031..19609
                     /locus_tag="AC0DU4_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005198 - structural molecule activity
                     [Evidence IEA];
                     GO_process: GO:0019068 - virion assembly [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="major tail protein"
                     /protein_id="HIN4236971.1"
                     /translation="MTQENKVTFGLENVHIAPIKTLAADGVITYGDVFRFPGAMELIL
                     DTKGETTPIKADNKNYHFMNSNEGYEGKLKIPHIIDEFATKILGEIKDPQTGVMTEKA
                     DASLTEFAIMFQFEGDKNKTRYVMYYCFASRPSLGSKTKNGTSTNERELSFKASPRPL
                     DTVVKRSITSADDKDAYDNWFKKVYEPTAVAA"
     gene            19621..20040
                     /locus_tag="AC0DU4_000995"
     CDS             19621..20040
                     /locus_tag="AC0DU4_000995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003047255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236972.1"
                     /translation="MRKIVLVGDQEYELGTNGYTPIAYKQQFGKDYFQDLFSMLKNQS
                     FMNELNKLETDKELTATNIDISMLSDFDMTFFNRLFWTFAKSANPQIKPYEQFFMEME
                     IFPIQEVGPVLMEMLNASMTTKKHQMNQNQLAKKSSQ"
     gene            20318..23413
                     /locus_tag="AC0DU4_000996"
     CDS             20318..23413
                     /locus_tag="AC0DU4_000996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000918318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail tape measure protein"
                     /protein_id="HIN4236973.1"
                     /translation="MAGNIKGIKIEIDGDTQPLQKALKAINKESVNTTNELKQIDKAL
                     KFDTGNVILLTQKQEVLQKQIGITRDKLETLRQAQSKVDEEFKKGNIGSEQYRAFQRE
                     VEVTQNVLKGYEGKLASLTQALEGNGDAAKNNQAQLKELQNEQKLLASESEKVVSSFK
                     LQESQMGANASEADKLALAEKKIGAQSEIVTRQIENLEKQLSLTKEQYGENSAEANKM
                     EAELNQAKTAYANLNQELGKLGSTAKSNQTQLKELQNEQSQLASEMSKVTSSFKLQES
                     ALGSNASEAERNALAQKKIGAQSEIVSKQISNLEQQLEITKKEFGENSTQANKMESEL
                     NQAKTAFNHLNDEMKGTKSAADSTQESLSEISRNLRAELLQQFSEKLSAISEKLVEVG
                     KEALEAAAQMQASNAQFTTVFGDMETQAREALNAIGQEMDIVPERLQGSFTQMASFAK
                     TSGLDTAEALDLTSRATRAAADGAAFYDKSIESVTESLQSFLKGNFANDAALGISATE
                     TTRNAAANKLYGKSFKDLSEAQKQLTLLQMVEDGNKLSGALGQAARESDGLENVMGNL
                     KQAGTNALSAIGQPLLEMMIPVFQTLATIVKGVAELFSSLPAPVKDFVVILGTVVTAV
                     GVIAPIFLSLQALAEFLKISIGEMIIAALPIIGTAIAIAAAVAAIVAIVKYLWETNEG
                     FRDAVTTVWNAILEVINAVVSEISNFVMSIFGTVVTWWTENQELIRTSAETVWNAIYT
                     VISTILDILGPLLQAGWDNIQLIITTTWEIIKIVVETAINVVLGVIQAVMQIITGDWS
                     GAWETIKGVFSTVWQAIQSIVQTIFSAIQSYISNILNGISGTVSNIWNSIKDTVSNVL
                     NAISSTVSSVWEGIKSTISSAINGARDAVSSAIEAIKGLFNFNISWPHIPLPHFYVSG
                     SANPLDWLSQGVPSIGIEWYAKGGIMTKPTIFGMNGNNIMVGGEAGNEAVLPLNDKTL
                     GAIGRGIAQTMGGTSPTINITITGNTVREEADISRIADEVAQRIADELQRKTQLRGGF
                     T"
     gene            23410..24132
                     /locus_tag="AC0DU4_000997"
     CDS             23410..24132
                     /locus_tag="AC0DU4_000997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150465.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail protein"
                     /protein_id="HIN4236974.1"
                     /translation="MIKHNELVIDGVRTSSFPFKVIVHDSPSIALGESKTALLEHGGI
                     SGAIVQTNKHRELVKKTYTIYLVKPTEEQMNQFMSLFIREKFWLESERVKTTRLWCYK
                     VNVSDLEEVQPGLYMTKATFTCHPTKHFKVTDTQRLTRSGTLNVQGSALAFPKITIVG
                     QSASETSFTIAGQVIRLERLTESLVMVNNPDNPSFKTTTGKPVKWSGDFITVDPAKVK
                     NIGVVLGPGIQSLEIETVWGWA"
     gene            24133..>26981
                     /locus_tag="AC0DU4_000998"
     CDS             24133..>26981
                     /locus_tag="AC0DU4_000998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000966215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005198 - structural molecule activity
                     [Evidence IEA];
                     GO_process: GO:0016032 - viral process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phage tail spike protein"
                     /protein_id="HIN4236975.1"
                     /translation="MLYLLNEDVRTVRWNGESLHEATSAIVKETMNGDFTLTVKYPIS
                     DSGIYQLIQEDMLIKAPTPVLGAQLFRIKKPVEHNDHLEITAYHISDDVMQRSITQMS
                     VTSQSCGMALSRMVQNTKTALGDFSFNSDIQDRRTFNTTETETLYSVLLDGKHSIVGT
                     WEGELVRDNFAMTVKKSRGENRGVVITTHKNLKDYQRTKNSQNVVTRIHAKSTFKPEG
                     AEKETTIRVTVDSPLINSYPYINEKEYENNNAKTVEELQKWAQSKFSNEGIDKVSDAI
                     KIEAYELDGQVVHMGDTVNLKSWKHNVDAFKKAIAYEFDALKEEYISLTFDDKAGIGG
                     SRASGGLSSAADAILGVTESAQEIALEKALQNADLDFDHKAGLLRQEISDDIELAKAR
                     AEEVKRELSDTINQRFNSFDNGPLKETKRKAEEALRNAGASSSLAQESKRIGLDSVAR
                     LEAFKSQTTSAQTALSGDLDALKRTIANDIRPKQAQAEAEIAKQVEALSRTKNELAGA
                     STLLAQEAKRIELDSVARLEAFKSQTTSAQTALSGDLDALKRTIANDIRPKQAQAEAE
                     IAKQVEALSRTKNELAGASTLLAQEAKRIELDSVARLEAFKSQTTSAQTALSGDLDAL
                     KRTIVNDIRPKQAQAEAEIAKQVEALSRTKNELAGVKSAQATYKETTTRRLSELTNLA
                     NGKASKSELTQTAEELSSKIASVQASGRNLFLNSLFKQDIPKTGIWTTSTYTATIDSE
                     SKYLGHKALKIIGLNPSGRDGGNPKVTYPALGQFGKVIPGSTTNQDVTISFYAKANKN
                     GIMLRSRLGNIGYKTGNVTLSTEIKRYAVHIPKGWTNESKRTTNEWLFNFNQEGTVWI
                     WMPKFEISDVDTSYSEAPEDIEGQISTVESTFKQRANSLEAGVSRLTEGLRTKADISS
                     LNVTAENIRQSVKSLETDTQNKLNQKLSQAEFEVRA"
BASE COUNT         8693 a         4642 c         6093 g         7553 t
ORIGIN      
        1 gatatttttc ggtatttttc ggattttggt cggggaattg gcggggattt ttttagcgaa
       61 tatgactaag aaataggtct gttgtcgctt cagcaagttc gtcctctact tgattgtaac
      121 gatcggtcat atagactttt gtatggccca gcgcctggct taattgttca agcggaaccc
      181 ctgcaataat gctttgagtc gtgaagaagt ggcgcatcat gtgaggtgtt acatgcaatc
      241 ctgttgcttc attcactaga ttgaagtttc tatttagctg gtttggattg atgagaccac
      301 ctttctcgtt gatagttata taatccttgt gctgttcctt gataattcct aactttcgct
      361 taatcttaga agcttcagct atcagataat agatcaggtc tgttccgata tcatcaaggc
      421 agacatatcg ctctgaatcc ttcgttttaa gccctccttt cccttttaag gtctggttgc
      481 ttcgactgtc tctaagatgc agtatagccc gtccgctgtc gttctgagtg atgtccattg
      541 gacgcaatcc aaagacttct cctcttctca atccaaaaat tgtcagatag gtcagagcgt
      601 agaattgttt tggcataatc tcttctgcct ttgctatcca agtcttgaac tctttgagag
      661 tcactttctt gtttgcagca gggatatcac tctggccgat gaaaacacct ttcaagcgat
      721 ttgagagcag attaccattt ttcacggcat cattcagcaa tgccatgaag ctggaattga
      781 gggtttgaac agtgtatctg gtatggttct gcaacttttc agcgataaat agttcatact
      841 catttctatc caaattttta agcaggatag aaccaaactt tgccttgata tggttattat
      901 agagattgtc attgaggtag tatgaagtgt cattccagcg ccctgttgac aatctctttt
      961 cggaatagat atcccaatat tgatcaagcg ttagattcgt attgatacct aattcttgtt
     1021 cttggatttg ttgctcaagc tctaccaagg ctgcacgagc ttgagggaga gttgtgaaac
     1081 cacttttact tttttctctt tttttacctc ggaagaaaaa agaacgtctg acatagtaac
     1141 gcttgccttt agcagtctca tagtaataga tatttgggta ttttgtttta ttatatttca
     1201 ttgtattctc cttgtttatc ggcttctgga caaggtctaa acattgagaa tattgacatc
     1261 acccctttca tggtgtaaaa tagggtatag aaaataggcc tttttaatgg ctgatttctt
     1321 ataaggctaa gcttcacaat caaactttgg cgagggcgat tgtggggctt ttttatttct
     1381 tgtttactat tcctcaagca atcttataaa atcattttct gtcatgattt caatatcttg
     1441 acctttttct aataaggttt gtgctttttt cattttactg cttaatccat ctgtgccaac
     1501 aactctccaa tcttgttccc caacaactaa gatattagtg tgtttggtca ctcctttttc
     1561 aggaatacca ccaactaacg cagcagcttt gttagcttct tttctagtca ttcgctcgag
     1621 ttttccagta aagcaaaagt acaaaccgta aaagtaatgg tctgggttca ttgctgcttt
     1681 ttcttcttct gtaggctgat agataaggtt ttccttgtat tgataacctt ttttcctttt
     1741 aaatccatac tgaccgagta agccagtttt attgtatcta tattctttta aaaaagcggt
     1801 gaggtcggaa aatgaatttg tggatagcaa gtattctaaa atcaatccgc ttgctcgtgc
     1861 atctgataga gcgttatggt gatctagctc aatattcaaa tttttagcta gtctttttag
     1921 tttgtaattc aattgtccag ggagagcaac cttggctaat cgatacgaac aaatgtattc
     1981 tatattatca aaatctagct cgtatttttg gtatacgtct ttaagagcac ccatatcaaa
     2041 ctgtgcaaag tgggctacaa ctatatctaa accaataaaa tcaacaatgg actttcttac
     2101 ttctgggaat gtaggtgaat caagaacatc ttcaggagta atgccatgga tgaaaatatt
     2161 gaaatcatca aattcttctt ctggattgat taaggtgtaa aatgtatcaa caatattccc
     2221 atctttaaat tttactaatc cgatagaaca aacactaccg cgaaagtcat tcgcagtttc
     2281 aacatctaaa gcaacatacg agtaagacat atgagtctcc tttcactcca tcaatgcaaa
     2341 gtattcctct tttaccatga cttcattagt catggtttta agattgtagt aggacatgaa
     2401 tttgaggtaa tcaaactctg tggggtcatc caagctttct agtgcgtctt ttacgagatg
     2461 atggatcata ttcctatcag cttcgttttc acagcgtagg cgagcgttct ggtactctga
     2521 gcgtgtgtgg tctttgtgtc cgagttcatg cagtagtacc ttaactctct cttttttgct
     2581 gagtttatta gataagaaag ctgtattggt ttctttttcg taaaatccaa gttcatcagg
     2641 tattagctca ccgtcaaaat cgacaatgcg aacctgaaaa tgacttataa tttctttttc
     2701 ggtcactaag cagtacctct aatcaccagc ttctttgaga taaccttcaa tgatagactg
     2761 gatgattttc ttcttttcat ctgttaattc tcgaccacca aacatcatga cattagatgc
     2821 catttcttca acatttaggg tcttcccttg ccaagtgtac tcttttgaat caccagcaat
     2881 agcaggatta tccgtgcgac caagtaaata atctgtggac acgttgaagt agtcagcaat
     2941 ttcttgaaga cgttcagcat ttggtttttt gtttttcata ctatagattg tatttctact
     3001 atatcctaat gtttcttcaa gagaatttat agaaattcca cgattttggc aaagttcttt
     3061 tattttttcg aacaaagaaa acattgattt atcaaccttt ctaaggcatg acaaaaaata
     3121 tttaaacttt tgattgtaaa tatgttgaca aaacgcaatc tatagtttag aatattattt
     3181 gtaagctaaa gagttagcga acaagacaac taaaaaataa agcctaatga aactgattgg
     3241 cgtccgtttt ctaggtagaa ccttactttt agtaggtctt ttctctatga ttaaattcta
     3301 aactatagat tgttttttgt caagaaattc gctaactttt tagataattt tttaaaagga
     3361 ggtgaggaaa tgagaccaag acgatatccg tatagtggga aaaaagagtc caccctcgta
     3421 aaggcagacc ctgaattagt agaaaaaatt ctaagaaaca ctagttttct tgagcattta
     3481 caagttctgt tagcaacgaa accgtagttt ctgtactgag tttatgagcg acaaggacgc
     3541 tattaagaat agcctttcta atttccatgt cgattgggta ttctttaaat acctcatcta
     3601 acatatcttt gataactgga atagcatcgt tgataatttc ttgagaaact tgtaaaacat
     3661 cttctttagt gagttttgac atataaaatt tcctcctttc tattggaatt ttgactaaaa
     3721 cggtgagagg tcctaatcaa gattattata gcaatttagg aagatattac ctcagtcttg
     3781 agactgatat aggaggttga atggaagata aaatcatcga acttgctgat tacttcatca
     3841 gcgagaacac aacgtacaga gaagctaaaa tagcgtgtga gaagctattt aaacaagcca
     3901 gccatgagat agaactcaga gcgctggaaa gtgaaacgaa gaaatagaaa ggagaaagat
     3961 gagtaaagaa ctaaagataa tcaaggctaa aatcaaaact cgtttgattg agcttgatat
     4021 gactcaagct gagttagcaa aacaagtatc tgtagcatca tcagttattt cagagttgct
     4081 gaagtatggc aaaggtagtg agtctgttaa ggaaaaagtt gcagatgttt tagggattga
     4141 gaacccttgg gaaaatagtt agagcatgag gaaatagtat gaacaacgca gcgcaaaaag
     4201 taacacggat tgacaaagat gcctgggaga ttgctacgga gctggcgaac gagtacggcg
     4261 tatctatttg tcacatcatc agcgagagcg tccgctactg tgcagagaat gccgaattta
     4321 aggagatgga cgttgtcgtt aaacgattgg tagtcggcag taaggtgctg gagtaggagg
     4381 gtggagatga atgaaatagt atggttttac tttgttgtca taatcaatct tatcattggt
     4441 tttgctacat actacgctag caaaagagac agaaaaaagc gcatcaacga gtataaaaaa
     4501 atacaagatg atgagcttga aagaattaga aataaattta atttatgatt ttttagaagt
     4561 cttttgaata aattttttat ttagtttttg tttgtgattg ttagctttat cagctaattt
     4621 taaagctttg tccaaatcaa cttcgcctgt aaaagttttg tagataagat cattcatctt
     4681 catagccttg tcggtttcag tatcaatctg agataccttt tcaagttctt gtaaccgtaa
     4741 ttcatgagct tgtttgactt tttcaagttc caaggtgtgt tgttgtttga gagtatctat
     4801 ctgataatga aattcttttt caagtttctc tacgatatgt gaatgttctt tggcctgttt
     4861 ttcaatctca gctttattgt tagcttttga tgcaatatat gaccataaac ctgagattat
     4921 tgcaagaatg acactaattg caggttgaat aagaatttga taatccataa gatttctcca
     4981 atcgttttat tttcattata ccaaatttag aaaggaatac tatgaacgaa atttttaatt
     5041 ttcacggaca agaagtccgt actttgacaa ttgatgacga gccgtggttt gtcgggaagg
     5101 atgtagcgga catcctagga tatagcaagg ctagaaatgc gattactctt cacgttgatg
     5161 aagaggacgc cctaaaacag ggcatcccta ctagtggcgg aacacaggat atgttgatca
     5221 tcaacgaatc tggtctctac tctctcatct tatccagcaa gttgcctcaa gctaaggaat
     5281 tcaagcgctg ggtgacttca gaggtcttgc cagctattcg caagcagggc ggatttatcc
     5341 gcgaggactt ggacgaggat gcctttatcg ctctattcac tggtcaaaag aaattgcgtg
     5401 agcaacaggc taccatgctg gaagatatcg actatctaaa gagtgagcaa ccgattcatc
     5461 caagctatgc tcagtcgtta ctgaagaagc gcaaagctcg ggtcgtggct tgccttggcg
     5521 gtattgacag tcctgcttat gcggataagg tttttgctca atcagtcttt agacaagctg
     5581 agattgattt caaagaccac ttcaacatta gtcgctatga cttgctaccc aagaagcatg
     5641 cggatgccgc tcttgcttac tggatgacgt gggagccaag cactaatacc aagatgaaaa
     5701 tcatgaaatt gaactcattt gatgacgtct agaaagggga agaagatgga caatgttcta
     5761 ctttcactgt ctgaatggat taaatctatt atcaaggaca caatcacaag gctagtcgaa
     5821 atagaaaaag atagtgatca ctatccagag ttgatggatg tgaacactac ctgcgaattt
     5881 ctaggaatta agtatgccac cttttcagat aattatcgtt acttaaaggg atttccaaag
     5941 gaattacctg gtaagaaatg gtcaaaaaga gccatcaaag aatggctctc taatcaaata
     6001 taataacttt actaaaaggc ttctggacaa ggtcttagca aaattatttg actatattat
     6061 agcacaaaaa gaggataagg agataaaaat gtttgaacca ccgattttag accagttgat
     6121 gggggttgga gccttactgc ttggatttgc aggggcttgc cgtcatatca aattgcagga
     6181 acaacgcaag gaagaagaaa gacgagaaga gcaagaattt gcgtctatga ttattcaagg
     6241 ctataaccat gcttacgaac gtggtagaga agctgaacgt caagaaatcc gcaagaatat
     6301 tcgtcgtccg ttcaagggct ttacctacga caacgaaccg cctcaaggat tgcgtcctga
     6361 gccattagct ttgccagaac ctaaacagtc tgcaatcaga cttctgtaat gaggagggca
     6421 ggaaatggaa gaattgattg aatcgctgga taacctgatt atgattgtta aagaactgga
     6481 aggaagggaa tcaacttcaa gacattttat tacgatatgg gaaaacgatt ataaaaatct
     6541 attactagtc aaagaatacc taaccgacta tgaaaaacta gcaaaggact atcgttatgt
     6601 gacccttaaa aataagctgc taaagattga aaaaatggag ctggaaggca ggcacatcta
     6661 tgaggatatg cggatgaagt atcgtgccaa tcgcaggaag tggggtgctc ggtatgtctg
     6721 aaattaagtg gataaaaatc acaaccgata tttttgacga tgaaaagatt tgcctgattg
     6781 atgccttgcc tgatcctgat gccatcttag tgatatggtt caagattttg acacttgctg
     6841 gaaaacataa cagtaatggt ttgttgatga tgactgataa ggttcactat acagatgaaa
     6901 tgttagctac tatttttcgt agaccattga atacagtaag aatggctatt ggagtttttg
     6961 aacagtttgg gatgattgag attatcgatg gtattattag cttgccaaat tgggaaaaac
     7021 atcaaaacgt tgacggaatg gagaaaatca aggaacagac acgtaaccgt gtagccaaat
     7081 accgtaaaaa acaaaaaaat cttgctcttg gtaacgttac aggtaacgtt acagtaacgg
     7141 acggtaacgc actagaagaa gataaagata agaataagaa tagattagat aaagataaga
     7201 ataagaaaag aataactact actagtagtg gtagtgaaga aaatatctta gaactttttc
     7261 aatctgagtt tcgtagactc ttatctggat ttgaaattga agaaatcaac catctactaa
     7321 atgagaatga tgtggatttg gtgaaagaag cattgaagac tgctattaac tcaggaaagc
     7381 cgaacatcaa atatattggt gggattttaa gaaattggca gatgaacaat gttaccactg
     7441 ttgaacaggt tcgtcaatcg gaaaagaaga acaaggataa gaaagaagaa caggaggcca
     7501 aggacgaatg ggggtactag aactaattga acaattcgag attgactatt atccgttaag
     7561 ctacgagaag aaaactcttt tagcagacca accaattcat caagtggttg cctgcttgtc
     7621 tgaaatggct agctggcatg aatgcggagg tcggctagta tggtagacaa tgtgtttgag
     7681 gaaatcgcct tatcttatcg taggaataca gaacaacaag aagagttctg cgaaaagcat
     7741 aacatccctt tgataaagat attgaggacc gagagtgttg tatgtcgcat gtgtgaatct
     7801 gagcggattc atgaagaaaa tcaggaaaga gtgaatgaac tggctaatgc tgagaatgag
     7861 cgagagagga aatactatct tgaaaagttc tctctttatg atgaagtttt gaaaaatgct
     7921 actttggaca attttgaaac accaaccgaa aaagaagcgg aaaagctagc ttttgcaaag
     7981 aggatttgtc gtgagtggtc tgagggtgct aggaacaaca tcgtgttaca aggagaagct
     8041 ggaacaggta agagccattt ggcttttgct atggttaagg ttctatctga gtacacgaaa
     8101 gagattgcta tttttattaa cgtaactgac ttgctgatga agattaaagc tgattttagt
     8161 caggaagagt ttctggtcaa taaaattgct agtgctaagt tcttggtttt ggatgattta
     8221 ggaatggaaa aagatagcga atggtcattt actattctct acaatatctt gaataagcgt
     8281 tcaaacacaa tcattaccac aaatttgatt tctgccgata ttcaaaaaag atatggcaga
     8341 cctttcatgt ccagactaat gaagggtgta gataaagacc atttgatggt tttcaatgat
     8401 ttgacaaaca agcgaaagca atatttttag aataggggtg gctgatgttt attttaaagc
     8461 atgggacaag agaggataag ccgtttctaa ggtctgcaat tgtcagtgtg actggcttgg
     8521 atatttcgtg ttccgaggag aagaaagcca tgcggtttat ttctcgggcg gcagccttac
     8581 aggttagcaa ggcattgaga ggttcctttg ggaacttcta ccctgtcgag gtggagtgat
     8641 gttagagctt tatttcgtct acaacgggca ctgtaagttt ttccttggga ggtttgacaa
     8701 tgtcgatgat ctcattgagc agatggaaga tcatcagtgg gctttctcgg ctatcactca
     8761 tccaagattt cagaagcaca ttggtcagcg gacgacacga tttgactacg gttctaagga
     8821 ttgttactat ttagcgactt tttcaggagg agaataatgg ctaaaaatat tttaatggat
     8881 ctagcatttg agaatcttca caaatgtatg ggaatttctg attggaaaga atctgattaa
     8941 gtaattcttg ttagttcagc taataaagaa caaattgagt cagatgaaag ttaccattca
     9001 gccggaaaat gtaattatct tggcaaacga atttgtatct tctgtgaaca agtgaagaaa
     9061 aataattaca tcactctaca taaatctatg ttagaaaaaa ttattaagac aatggaatca
     9121 tttacagatg cagaacaaat gaagggagaa gaaaatgatt gaacttatta aagaatttgg
     9181 catggcgatt ctgtggctat ttctcggtta cttaatcggg gaacgtgcag caagaaagat
     9241 gatcaataac gttacattgg tagggcgctt gacgaaagac cctgaattaa aatatacgcc
     9301 gtcgaatgtg gcggttgcga cgtttacact tttagtggga ggtaagaaac atggttggag
     9361 taacctatca ggaaattcat ctctttgttg aatttttgaa agagcagtac gggcaaggtc
     9421 gtccagacta tattgaagcc ctgaacgact tagacggtct ggtggaagtc tcctacagag
     9481 aagctattga aagattttta gaagatgaag tacgataaac agactgagat tgacggactg
     9541 aaacgcacga tcgagcaaaa cgaagagaag ataatcgagt attcgaagcc gtgcgatgca
     9601 cgcaagagac ggattagagc gctggagcgc gatttgttga ggaaaaagaa taaagaatta
     9661 agacggaaag cggaggagtt ggaagatgat ggaagagtta aagaaaaaag ttaatgcagt
     9721 atacaattgg acggtagaag acgggaagcc gcaacctccc cagcaagatt taccacaagc
     9781 agtaaaagac cgggtggact atttttggga aatggcagaa gatggtatga catttatggg
     9841 agcgatggaa tgcatctttg ctgatgaaaa gcctacagac tatgaattgg gagctactaa
     9901 gggttggttg ccaaaatcta aggagtttga tgattggatt ggctattcgc caagcatggc
     9961 tcaggtagtt attgcagttt atttgattta tggaggaaac taagatgaat aagcaggaat
    10021 tgattaaaaa attagaggaa cgaagaacaa taattgggaa ttttcaaggt tatgcagtga
    10081 gttatttttg gatttactgg attgtcgaga agtgattgat attccgatta gtaaagaact
    10141 tggtattact gaacaaacag ttagatttta tggaacgaag acaagtagga atagatatcc
    10201 gatctcgaca attttgataa cttgtttaca tttttgaaaa acttggaggt ggaaattgaa
    10261 aaaattgagc gacgaagaac tcaaaacgtt agacagagaa cttttcaaat ttcaaaacat
    10321 tcaacgcaca atagacttaa gaaggctaga attagaaacc agaaacccag atgctcaaag
    10381 tgggccaact gtaggaataa gcaaacctac cgaaactatc gcaatcagaa tcgcagatga
    10441 tccgacttta aaatttcttg aaggatttaa agggattatt aacaaactct tgagtaatct
    10501 agtggatgag gatatggaaa tctttaatct acgctggaga taccctcaac tgagatggga
    10561 agaaatagca gaacagaaat tcatgagcaa agctacaatc tatcgacgta gaaggattat
    10621 cttagaacag tacgctatac tgaaaggtga gttgtaaata agattgagac aaaagacatc
    10681 ttgaagtctc acaaaaaaag gtctattatg atagcatgaa cttctgaaac aaaaacacaa
    10741 atcacatgtt ggagtcatcc tatttttaca gaaaagttgt ttaacagagg aacatcatga
    10801 gtcagcaacc agctggcttt ttgttttgta gaaaggaggc agttatggaa tttgtatcac
    10861 cgataaaaga caatgatgat attcaagcta tgaaagatta tctcagagaa tggaatgaga
    10921 tgtattatat gctattcatc acaggcctga atactggctt acgagtcgga gatatactta
    10981 ccttgaaagt taaagatgtt caaggttggc acatcaaact gagagaacgg aagactggta
    11041 agcagataac aagacggatg acaaaagaac tcaagaaaga aatgaggaga tatgttgaag
    11101 gcaaaccatt tcatcatttc ttattcaaga gtaggcaagg tcagaataaa gcgatcactc
    11161 gtgagcgagt ctatcaaatc atacatgaag cagctgaaga acttggcatt gataatgttg
    11221 gcacacatac aatgcgcaag acattcggct ataaatatta caacaagaca aaggacgtag
    11281 gaacattaca gaaaatgttc aatcactcat cacctgcaat caccctgaga tacataggga
    11341 tagagcaagc agagcttgat gacgcactac ggaactttgt catttaattt tttagatatt
    11401 actttcacat aatgagttaa gcataaacta aaaaaatgaa actcttcaaa acccatgctt
    11461 agtaagggtt tgtgattcag agtgagttta acaaaatata agatatgtga aagtgatggg
    11521 taaaattggt atagttacag gaggtagaaa atgataaaag aataccgtat ttgtaaatgg
    11581 aatgcacata ccgctaacag ccatactagt aaaatggggt aattttttta aagaatcaga
    11641 atgagacaaa agacgtcttg aagtctcaca aaaaaaggtt tattatggta gcatagattt
    11701 cttgtatgag gaggggatag gtcaaaggcc tgtccctttt agcgttgaga aaggaggttt
    11761 gagatgtata acaaacctgt cagaccatcc ttgaaatcta agaagtggga gaagttccgt
    11821 gataggataa tgcgtaagca tgattatctt tgccaagaaa gtttgcgtta cggaatttct
    11881 gttcaagcag aaatggttca ccatatcttt cctgtatctg aatatcctga acttgaattc
    11941 gttgaatgga attgtttgcc gttgacgaat aaaaaacaca atacgtttca cgatagagtg
    12001 aacgatagag taatcaatca aggattgtat tggcagaaaa aaagaaaaaa agaattttta
    12061 aattttttca aaaatgaaaa atgaaaattt ttagtccccc ctctttttga aaaatcattt
    12121 cggccagtag ggtaccggtg aagggaactt tttccaagtc gggggccttc aaacaaaaag
    12181 ggggtaaaaa ctaagcgatt ttgacgaaag gaggtagttt ttggctaaac caattacagc
    12241 aaagtcgatt aagtcaaaag tggtcaagca gatgaaagac ttgggcactt atcggaaaga
    12301 gttcgaaatg atcattgaca ttttcgcagg tatgttatac cagtatcaga aacttgctca
    12361 agattatgct aacttgggtt atccagtaac agacacctac gtcaataagg ctggtgctga
    12421 aaatgagcgc aaagttccaa tcttgacagc tatggaaatt ttgaggaaag acattctcag
    12481 ctactctaat cagctgatga tgaatccgaa atctctcggt gaggtagtag aacaagaagg
    12541 tgattcagtt cttactgagg ttctgaagtt caagaacgaa atcaagaaga agcgagtatc
    12601 tggaaatggg taatcttgat aaagcaaaag aatacgctca acacgtctta actcaccgag
    12661 aagaacattg cgaagagaac attcttgctg ctgaacgttt tttccgtgat ttagaaaatc
    12721 ctgcttttga gatggatgag gatatggtgg attttgttat tcactttatc gagaacgtga
    12781 tagttcacca acaaggcgat gatatgtttg cggtatctat ccgtaacaag ccattgcttt
    12841 tgcaaccgtg gcaacatttc gttgtagtta atctgtttgg tttttactac aagggtacga
    12901 atgagcgcag gttcaaagaa gcgcttatca tgcttgctcg gaagaatggg aagacctcgt
    12961 ttactgctgc aatcgcactt gcttatcaga tattagatac agatagcggt tccaaatgct
    13021 atatcgttgc taactcagtc aagcaagcga tggaagcttt tggtttttta agattcaacg
    13081 ttgaacgctg gaatgataag aacattcgta tcaaggataa taaccaagaa cactctatca
    13141 ccgccaattt tggtgatgaa ggttctttct ttatccaggc tttagcgaat gatgagagcc
    13201 gtctggactc tttgaacgga aatgttatca tcttggacga agctcacaca atgaggaaca
    13261 gtaagaaaca tggtcttatg aaaaaaacaa tgtcagcata ccgtaacagt atgctttttg
    13321 ttatctcaac ggctggggat attcctaccg ggttccttgc taaccgtctg aaatactgtc
    13381 aaaaggtgct caagcaatta gtcactgatg attcattttt catcttcatc tgcaaagcta
    13441 atcaatctgc tgatggggac gtggtgaact atctggacga gaatatcctc aagatggcta
    13501 atccgtcatg gggtgtcacg gtttcgctca aggctctcaa ggaagaagca gagcaggcta
    13561 tgaatgatcc tcagacaaga aatgagtttt tcaataagac cttgaatatc ttcactaact
    13621 ctatgaacgc ttattttaat cctgatgagt ttattgcgtc ggatagttgc tacgattgga
    13681 gtttagaaga gctggcacgt ttgcctattc gttggtatgg tggtgcggac ttgtcaagat
    13741 tgcacgactt aacagctgct gctctctatg gtgtctatca tgacggtgag aaagacgttg
    13801 atatctgtat cacacatgct ttcttccctc ggattaatgc tcagaaaaaa gctaatgatg
    13861 acgggattcc actctttggg tggcagtctg acggttggtt gacgatgagc aacactccga
    13921 ccgtcctcta tgatgatatc gtcaaatggt tcatcaagat gagggagaaa gggttcaaga
    13981 ttgctgctgt cggaatggat aggaagtttg gccgtgagtt cttgacgaag atgaaacaag
    14041 ctcggttcaa gatgattgac caacctcagc ttttttatct gaaatcagag ggattcagac
    14101 ggattgagtt taaagttaag aataaagaat tttactatct tcattctgat gcttacgaat
    14161 actgtgtgag caatgttaga gcaattgaaa aggtggacga tgctgtgcaa tatgagaaat
    14221 tagatggaga cggtgggact gcaaggattg acttgtttga tgccagcgtc tttgcttgta
    14281 tacaggctct tgctaatctt ggcaagggtg gtgatgtgat gagattcttt gattaggtga
    14341 attatgaatg aaatagtatt atcagaacat gaaattaact tgctgatcaa caaagggcga
    14401 gttaaagtaa ttttaaacgg ggaagtagta actattcgtc aaagacatat gaaaaatttg
    14461 atggctgaaa cagtaaaatg ggaaaaacag gtaattgatg tcagtcagaa tatcgtaaga
    14521 aataaacact ttgattcact ttttcaaaat acttttcgtt agaaaggagg tgaggaaaca
    14581 tgggtatttt tgaaaagttt tggaaacgaa acaagccaag taagccaatc aacatgctga
    14641 gtcattcaga tttagggttg tcaaacctga tggactcgta tgtacctttg gccagaaatc
    14701 cagatgtggt gacagcggtt aataagattg ctgatttggt ctctaatatg accatccact
    14761 tgatggagaa tacagataaa ggtgatatca gaatccgtga tgggcttgct agaaagattg
    14821 acatcaatcc gtgtaaacac atgacaagga agtcatggat tttcaagatt gtgcgcgatt
    14881 tgcttttata tggcgatggg aactctgtcc tacatgtgga atatgaacct gttacggatt
    14941 atatttctaa tctaagacca tttccgatga gagaggtttc attccaaaca gataaggatt
    15001 cctatgtaat ctcatttagg ggtgaagaat attcccctga tgaagtagtc cacttcgtca
    15061 tcaatccaga tccagatatt ctatacattg gtactggttt tagggtgacg ttgacagatg
    15121 tggttcaaag tttgaacatg gctaccaaga ctaaaaaaag ctttatgaac gggaagaata
    15181 ttcctagtct tatcgttaaa gtagactcgt ctagtgctga actagattcg gagcaagggc
    15241 gtgagcgtat cgctgagaag tatttgagta ctagcagggt tggcgctcca tggattgttc
    15301 cagaggcatt gctggacatt cagcaggtaa aaccgcttag tctaacggac atcgctttaa
    15361 acgagtctgt ggaattggat aaaagaacag ttgcaggtct attaggagta cctgctttta
    15421 ttttgggtgt aggagagttc aacaagacag agtataacaa ctttgtaaat acgactgtca
    15481 tgagtattgc taccactatt actcaaacac taaccaggga cttacttttg tctagcaatc
    15541 gttacttcaa gctaaatcct cgttcactct tctcttacaa cattacggag ttgtctgctg
    15601 ttgctcaaca aatggcaaac agtgctgcaa tgcgtcgtaa tgagtggagg gattggctag
    15661 ggatggctcc tgatcctgag atggaagagt tgattgttct tgaaaacttt ctccctcagg
    15721 agaaactagg agatcaaaat aaactgaagg gaggtgagga agagaatgca aaagcgaaat
    15781 agctatcgtg ccactcaatt tcaaacgaga gaagaagaat ctggagactt ggtgttgagt
    15841 ggctatttta taaaatttga tgaagagacg gagttgtggc gtggttatca tgaagtaatc
    15901 aagcgtgctg gtgttgagaa agctgtcaca gacgctgata tcagagcttt atttaaccat
    15961 gatgatagcc ttgttctcgg tcgaacaggt aacggaactt tgacactggg tgttgatgat
    16021 gttggtcttt ttggagatat catcattaac aaggatgatc ctcaagctgt tggggcctat
    16081 gcccgtgtca agcgtggaga tgttataggg tgtagctttg gctttatccc ggtaaaaatc
    16141 gaaacggaag aacgtgaaga tggttcgtat ttggacactg tcttagagct agaaatcttt
    16201 gaagtgagtc catgtacttt cccagcctat ccacaaacgg aaattgctgc acgacaaaaa
    16261 gacttcgaaa gtcagaagcg tgctaatcgt gaagcgctag acaagcgcaa gaaagaaatt
    16321 aaggagaaat ttaagctatg aataaggcat taatctttgg tgctcgtatg cgagcaaaag
    16381 caactaaggt agttgagttg gaagaaacta tcgaagaatt gaacaaacgt tcggttgttg
    16441 agttagaaaa gttggatcgt gctaaaaatg atgaagaagt tttagcagtt gaaaagactg
    16501 tagacggtct tcaaagggaa attgaagaaa aagaagctga aaaagtacag cttgaaaacg
    16561 agatcgatga gttagataaa caaatcaaag agcaaaatcg taaagcacca actccgggga
    16621 aaatggaaga acgaggagga aagacattgg gacaacgtga agcatttaat cattacttac
    16681 gaacaaaaga agcgcgtgct gatggtttca aatctgccga aggggaagca atcattcctg
    16741 ttgaattgat gacgcctaaa gaagcgaaac aagacaagac agatctgact tcattggtca
    16801 acatcgttaa tgtcaagaac gcaagcggta aatggtcagt tgtaaaattg actgatcaag
    16861 caatgaacac tgttgaagag ttggaagaaa accctgaatt ggctaaacca acctttacaa
    16921 aggtgaacta tgaaatcaaa acacgtcgtg gtcatttgcc agtatctcaa gaatttattg
    16981 atgacgctga ctacgatgtc atgggattgg ttgctaaaca aactaagaac caagaacgta
    17041 tcactaagaa taaagagatc gctaaagttc tcaagacagc tacatctaaa agcgcagctg
    17101 gtttggacgg cttgaaagat attctcaacg tggaattgaa aacatactac aatgcaacta
    17161 tcgtatgtac tcaatctatg ttcgctgctc ttgataaaat caaggacaag gacggtcgct
    17221 acatgctcca aacagatatc acatctccaa ctggctacaa gtttgctggt cgtgttattg
    17281 ttgtttatcc agatgatatc attggagaaa gcaagggaga tttgaaagcc ttcatcggtg
    17341 acgttggaga atttgcgaca ttgtttgacc gtgcgcagac tactgtcaaa tggcaagatg
    17401 acaaaatcta cggtcagtat ttggcaaccg ctaatcgttt tgatgtagta aaagtagacg
    17461 gagatgcagg attttatgtg acctatacag atgctgtttt gtaaggaggt agtaaatggt
    17521 atataaggta atccgtcctt ttaaggactt acgagaccca aagaaacatt gctataaggt
    17581 tggggataat taccctagag ttaagcacaa acttgataaa gagtttgcgg agactctgct
    17641 aaatggggca aatagtgcag gatctatctt tttgatgaat gtagaagata aggatatgtc
    17701 gaaagatgac acattaacta cagaagtaga aaaggaagaa acaaaggtag tagatgggaa
    17761 acctgaagag ggagacgagg agtagttatg gacaatgttc aattattaga attgcttaag
    17821 ctaaaattgg gtatagcaac aaaactacgc gataagccct tggagaaaat catcgaagct
    17881 gtcaaaacag aactagaaga taacttagga gttctacttg acttagacag ctcagaagac
    17941 caaatgtttg tagttgattt tgcagccttt cgctatgagg gtggggtgga tatgccacgt
    18001 caccttcagt ggcgactgca taatttacag atagcatcaa agaaaaaggt caagaatgtg
    18061 gaatcatgaa ataaaattga tctctaaaaa aatcacaggt aaggacaagt tactacaacc
    18121 aatctctgaa gatgttgaag ttactctgtt gtgtcgtaaa aagaatgtta ctcgctctga
    18181 attttatcaa gcaaaccagg caggtctaaa accgagcttg gtcgttgaga ttcgaaattt
    18241 tgagtatgag aatcaggagt ttgcgaaatt tgaaggcaag caatatcgta tcttgaaaac
    18301 ctatcctatc gattctgaaa ttttagagtt gactttgaca gaggtcttga aatgagtaat
    18361 gaccttgctg atttgatagc gaaagagctt gcagcttact ctgatgaggt tactgaagaa
    18421 gtggataaga ttgcagagca agtgactgat gagactgtgg atgagttgaa agagacaagt
    18481 ccgaaacggt acggaaagta tcgtagaagt tggaaaaaga agaagttggc caatggctct
    18541 tttgttgtgt tcaacgcagt tgcaagtctt actcacatac ttgaaaacgg gcacctttca
    18601 agaaatggtg gtcgtgtcgc tggtatcgtc cacatcaagc cagctgaaga aaaagcaatt
    18661 cagaactttg agaagcgaat caaggagatt gggaaatgaa gctatcagac tttgctgcta
    18721 ttttggaaca ggcaaacttg cctgtcactt atcgagcgtt taaaattgga aacgctcctg
    18781 acctacctta cctggtctat tatgaatcaa gtccagtcat caattcagct gacaacacgg
    18841 ttaatcatca gattaagagc gtgacagttg agctggcttt tgagagtaag gatgaagatt
    18901 tggaagaacg tctggaagag ctgtgggcaa accacaagct cttttttgaa gttcaagaag
    18961 aaacatttat cgagactgaa agactctatg tcaagtctta cacagtctat ctatactaag
    19021 gaggaatgac atgactcaag aaaataaagt aacctttggc ctagaaaatg tacatatcgc
    19081 acctatcaag acacttgcag cagatggagt tatcacttac ggcgatgttt ttcgttttcc
    19141 tggagcaatg gagctgatac ttgatactaa aggggaaaca acccctatca aagcagacaa
    19201 caagaattac catttcatga attcaaacga aggatatgag ggtaaactta aaatcccaca
    19261 catcattgat gaatttgcga caaaaattct tggtgaaatc aaggaccctc aaactggtgt
    19321 tatgactgaa aaagcagatg cgagcttgac agagttcgca ataatgttcc agtttgaagg
    19381 cgacaaaaac aagactcgct atgtgatgta ctactgtttt gccagtcgcc catctcttgg
    19441 ctcaaaaact aagaacggga catcaaccaa cgaacgtgaa cttagtttca aagctagccc
    19501 gcgtccattg gatacagttg tcaagcgttc tatcacatca gctgatgaca aggatgcgta
    19561 tgacaactgg ttcaagaaag tgtatgaacc tactgcagtt gcagcttaag gagaagatct
    19621 atgcgtaaaa tcgttttggt tggtgatcag gagtatgagt tggggaccaa cggctatact
    19681 cctattgctt acaagcaaca atttggaaaa gattattttc aagatttgtt ctcgatgttg
    19741 aaaaatcaat cattcatgaa tgaattgaac aagttggaaa ccgacaagga attgacagcg
    19801 actaatattg atatttcgat gttgtcagat tttgacatga cctttttcaa ccgtcttttt
    19861 tggacctttg ctaaatctgc aaatcctcaa atcaagcctt atgaacaatt cttcatggaa
    19921 atggaaatct tcccgattca ggaagttgga cctgtgctga tggaaatgct aaatgcgagc
    19981 atgacgacaa aaaagcacca gatgaatcag aatcagctag cgaagaaatc ttcacagtag
    20041 aatcctactt atcttgctgt aaagaaactg gtctttctat tgatgatcta aagcacattt
    20101 caatcggaat ggctctggat tatcagacgg attatgtgaa tctacggagc gaggataagg
    20161 gtggcgaacg gaaagccacg caagctgatt ttgacagttt ttaaagaaaa atgagtgctg
    20221 agagagcgat tctgagacca agttccttgg tctggctgca ttatcagtgg tagaagttct
    20281 ctcagcgctt ttctattttt ttgagaaagg aggaaatatg gcaggaaata tcaaaggtat
    20341 caaaattgaa atcgatggcg acacgcaacc cttgcagaag gcgttaaaag ctattaataa
    20401 agagtctgtt aatactacaa atgaactaaa acaaattgat aaggctttaa agtttgacac
    20461 tgggaacgtt attttactaa cccaaaaaca agaagtctta cagaaacaaa taggtataac
    20521 cagagacaaa ctagaaactt taagacaagc ccaatctaaa gtagatgagg aatttaaaaa
    20581 ggggaatatt ggttctgaac agtatcgcgc tttccagcgt gaagtagaag tgactcaaaa
    20641 tgtcctaaaa ggatatgagg gaaagcttgc cagtctcact caagctcttg aaggaaatgg
    20701 tgatgcagcc aagaacaatc aagctcaact aaaagaattg cagaatgaac aaaaattgct
    20761 tgctagtgaa tctgaaaaag tagttagttc atttaaactg caagaaagcc agatgggtgc
    20821 caatgctagc gaagcagaca agttagcatt agccgaaaaa aagattggcg cacagtctga
    20881 aatcgtcact cgtcaaatcg aaaaccttga gaagcagtta agcctaacta aagaacagta
    20941 tggcgaaaac tcagccgaag ctaacaagat ggaagcagag ctaaatcaag ctaagaccgc
    21001 ttacgctaat cttaatcagg aattaggaaa acttggtagt acagctaaga gcaaccaaac
    21061 gcaactgaaa gaattgcaga atgagcagag tcaacttgct tcagagatga gtaaggtgac
    21121 aagttcattc aaactgcaag aaagtgcttt gggttcaaat gctagtgaag ccgagagaaa
    21181 tgctcttgcc cagaaaaaga ttggtgccca gtctgagatt gtaagtaaac agatttcaaa
    21241 tctagaacag caattggaaa tcactaaaaa agaatttggt gagaactcca cacaagccaa
    21301 caagatggaa tctgagctaa atcaggctaa gactgctttt aatcatctca atgatgagat
    21361 gaagggaaca aagtctgctg ctgatagcac tcaagaaagt ttaagtgaaa tctcaagaaa
    21421 tttaagagca gaactacttc aacagtttag tgagaagttg agtgctattt cagaaaagct
    21481 tgtggaagta ggaaaagaag cgttagaagc agctgctcaa atgcaagcta gtaatgctca
    21541 atttactacc gttttcggag atatggaaac ccaagcaaga gaagcgttga atgctattgg
    21601 tcaggaaatg gatattgtcc cagagcgttt acaagggtca tttactcaga tggcttcatt
    21661 tgcaaagact tcaggattgg atacagcaga agctttggat cttacttctc gtgcaactag
    21721 ggcagcagca gacggtgcag ccttctatga caaatctatt gagagcgtga cagagagctt
    21781 acaatctttt ttgaagggaa actttgctaa cgatgcggct cttggcattt ctgcaacaga
    21841 aacgaccagg aatgccgctg caaataaatt gtacggaaag tcattcaagg acttgagcga
    21901 agcgcagaag caattgacct tgcttcagat ggtcgaagac ggaaataaac tctcaggagc
    21961 tcttggacag gctgcaagag aatcagacgg cctagaaaac gtgatgggga atctgaaaca
    22021 agctgggacc aatgcattat ctgctattgg tcaacctctt ctagaaatga tgattcctgt
    22081 ttttcaaacc ttggcaacga ttgtgaaagg tgtagctgag ctgttcagtt ccttacctgc
    22141 tccagtaaaa gattttgttg ttattttagg aacagttgtg actgctgtag gggtcatagc
    22201 ccccatattc ttatcgttgc aagcccttgc tgagttttta aaaatatcta ttggagaaat
    22261 gataattgcc gcattgccaa ttattggaac agctattgca attgctgctg cagttgctgc
    22321 aattgttgct attgtgaaat atctctggga aactaacgaa ggttttcgag atgcggtcac
    22381 gaccgtttgg aatgcgattc ttgaagttat caatgcagtc gtatcagaga tttctaattt
    22441 tgtcatgagt atctttggaa cggttgttac ttggtggacg gagaaccagg aacttatcag
    22501 gacaagtgct gagactgtct ggaatgccat ttatacggtc atcagtacaa tactggatat
    22561 acttggcccc ttgctccaag ctggctggga taacattcaa ctgatcatta caacaacttg
    22621 ggaaatcatc aagatcgttg ttgagactgc aatcaatgtt gtccttggtg ttatccaagc
    22681 agttatgcag atcattactg gtgattggtc aggagcttgg gaaactatca agggagtgtt
    22741 ttctactgta tggcaagcta ttcaaagcat tgttcagact attttctcag ctatccagag
    22801 ttatatttca aatattctca acggcatttc aggaactgta tcaaatatct ggaacagcat
    22861 caaggacact gtctcaaatg tgttaaatgc tatatctagt actgtatcaa gtgtttggga
    22921 aggtatcaag agtaccattt caagtgctat caatggtgca agggatgctg tttcttcagc
    22981 tattgaagcc atcaaaggat tgtttaactt caacatcagc tggccacata tcccactacc
    23041 tcacttttac gtgagtggtt cggccaatcc attagattgg ttgagtcaag gtgttccaag
    23101 tattggaatc gaatggtatg ccaaaggcgg tatcatgacg aaaccaacta tctttggaat
    23161 gaatggtaat aacataatgg ttggtggtga agctgggaat gaagcagtat tgccacttaa
    23221 cgacaaaacg cttggagcca tcggtcgagg tatcgctcaa actatgggtg gaacttcacc
    23281 aaccattaac attaccatta ctggcaacac tgtcagagaa gaagccgaca tcagtcgtat
    23341 tgctgatgag gtggctcagc gtattgctga cgagttgcaa cgtaagacac aattgagagg
    23401 agggtttaca tgataaagca taatgagctt gtgattgacg gtgtgagaac atcgtctttt
    23461 ccgtttaaag tcattgtcca tgattctcct tcaattgctc tgggagagag caagacagct
    23521 cttttggagc atggtggtat cagtggagca atcgttcaga cgaacaaaca tagggaattg
    23581 gtcaagaaaa cctatacgat ttacttggtc aaacctactg aagaacagat gaaccaattt
    23641 atgagtctgt ttatccgtga aaagttctgg ctagagagtg agcgagtcaa aacaactcgt
    23701 ctttggtgct ataaggtcaa tgtgagcgac cttgaagaag tgcaacctgg tctttacatg
    23761 accaaagcaa ccttcacttg tcaccctacc aaacacttca aagtcactga tacacagaga
    23821 ttgacaagaa gtgggactct gaatgtgcaa ggttctgctc ttgcttttcc taaaatcaca
    23881 atcgttggtc agagcgcttc tgaaacttcg tttacaatcg ctggtcaggt catccgtctt
    23941 gaacgactca ctgagtcact tgtgatggtc aataatcctg acaatccaag ttttaaaaca
    24001 acaacaggga agccagtcaa atggtcaggg gattttatca cagttgatcc agcgaaagtt
    24061 aagaatattg gggttgtttt aggcccaggt attcaatcgc ttgaaatcga aacggtttgg
    24121 gggtgggcat aattgcttta tctacttaat gaagatgtaa gaactgttcg atggaacggg
    24181 gagtcacttc atgaagcgac ttcggcgatt gtgaaagaaa ctatgaatgg cgattttacc
    24241 ttgactgtga aatatcctat ttctgattct ggtatttacc agcttatcca agaagatatg
    24301 ctgataaagg ctccgactcc tgtcttagga gcgcagctat ttcgtatcaa gaaacctgtt
    24361 gagcacaatg accatctgga aatcacagcc tatcacattt cagatgatgt gatgcaacga
    24421 tctatcacac aaatgagtgt gactagtcag agttgtggca tggctctttc tcgcatggta
    24481 caaaacacca aaacagctct tggagacttc tcattcaaca gtgatatcca ggaccgtagg
    24541 acattcaaca cgactgagac agaaaccctg tactctgtat tgctggacgg caagcatagt
    24601 atcgtcggaa cgtgggaagg cgagctggtg cgtgataact ttgcgatgac tgtaaagaag
    24661 agtcgtggtg agaatcgtgg tgttgttatt acaacacata agaatctgaa ggactaccaa
    24721 cgcacaaaaa acagtcagaa tgttgtcaca agaattcacg caaagtcgac ttttaaacct
    24781 gaaggtgctg aaaaagaaac gactatcaga gtgactgttg atagtcctct tatcaactca
    24841 tacccttata tcaatgaaaa agagtatgag aacaacaatg ctaaaactgt tgaagagttg
    24901 cagaagtggg cacagtctaa gttttcaaat gagggaattg acaaggtctc tgatgctatc
    24961 aagattgaag cttatgaact tgatgggcaa gtggtccata tgggcgacac ggtcaatctc
    25021 aagagctgga aacataatgt cgatgcattc aagaaagcta ttgcttatga gttcgatgcc
    25081 ttaaaagaag aatacatctc tctgactttc gatgataagg caggtattgg tggttctaga
    25141 gcttctggtg gcctatctag cgcagccgat gcaattcttg gagtgacaga atctgcacaa
    25201 gaaatcgccc ttgaaaaggc tcttcaaaat gctgacttag actttgatca taaggctgga
    25261 ttgcttagac aggaaatttc tgacgatatt gaactggcca aagccagagc tgaagaagtc
    25321 aagagagaac tgtctgacac tatcaatcag cgatttaata gctttgacaa cgggccattg
    25381 aaagaaacta agcgcaaggc tgaggaagct ttgcgaaatg ctggcgcaag tagttctctt
    25441 gctcaggaat ccaagcggat tgggctggat tctgttgcta gacttgaagc gtttaagtcg
    25501 cagactacga gcgcacaaac ggctctgtcg ggtgacttgg acgctctgaa acggactatt
    25561 gcgaatgata ttcgaccgaa gcaagcacag gctgaagctg agattgccaa gcaagttgaa
    25621 gcacttagcc ggactaaaaa tgaactggct ggcgcaagta ccctgcttgc acaggaagct
    25681 aagcggattg agctggattc tgttgctaga cttgaagcgt ttaagtcgca gactacgagc
    25741 gcacaaacgg ctctgtcggg tgacttggac gctctgaaac ggactatcgc gaatgatatt
    25801 cgaccgaagc aagcacaggc tgaagctgag attgccaagc aagttgaagc acttagccgg
    25861 actaaaaatg aactggctgg cgcaagtacc ctgcttgcac aggaagctaa gcggattgag
    25921 ttggattctg ttgctagact tgaagcgttt aagtcgcaga ctacgagcgc acaaacggct
    25981 ctgtcaggtg acttggacgc tctgaaacgg actatagtga atgatattcg accgaagcaa
    26041 gcacaggctg aagctgagat tgccaagcaa gttgaagcac ttagccggac taagaatgaa
    26101 ctggctggcg tgaagtcagc gcaagcgacg tataaggaga cgacgactcg tagactgtca
    26161 gaactgacca acttggccaa tggtaaagcc agtaagtcag aactcacgca gacagctgag
    26221 gagctctcta gtaagatagc gagtgtgcag gcatccggtc gaaatctatt cttgaactca
    26281 ctatttaagc aggatattcc aaaaacagga atttggacaa cgagtacata tacggctact
    26341 atcgatagcg aaagtaagta tcttggacac aaggctctta aaattatagg tctgaatcca
    26401 tctggccgtg atggaggtaa tcccaaggtt acttatccag ctctgggtca attcgggaaa
    26461 gtaattcccg gaagtacgac taatcaagat gtaaccatta gtttttatgc taaggcaaat
    26521 aaaaatggaa taatgctaag atctcgatta gggaatatcg gatataaaac tggaaatgtg
    26581 acattgtcga cagaaattaa gcgatatgct gtccatattc caaaaggttg gacaaacgaa
    26641 tccaagcgga ccacaaatga atggttgttc aatttcaacc aagaaggaac cgtttggatt
    26701 tggatgccga agtttgaaat aagcgatgta gatacttctt attcagaagc tcctgaagat
    26761 atagaaggtc agatttcaac agtagaatcg accttcaaac aacgagccaa ctcgctcgaa
    26821 gctggtgtaa gccgtctgac tgaaggcctt agaaccaaag cggatatcag ctcactcaat
    26881 gtgactgctg agaatatccg gcaatctgtg aagagccttg agacagacac gcagaacaag
    26941 ctaaatcaga agttgagtca ggctgaattt gaggtgcgag c
//
LOCUS       DBMVGT010000021        26405 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.021, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000021 DBMVGT010000000
VERSION     DBMVGT010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 26405)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26405)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26405
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.021"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..426)
                     /locus_tag="AC0DU4_000999"
     CDS             complement(<1..426)
                     /locus_tag="AC0DU4_000999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004560 - alpha-L-fucosidase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HIN4236976.1"
                     /translation="MKKIKPHGPLPSQTQLAYLGDELAAFIHFGPNTFYDQEWGTGQE
                     DPERFNPSQLDAREWVRVLKETGFKKLILVVKHHDGFVLYPTAHTDYSVKVSPWRRGK
                     GDLLLEVSQAATEFDMDMGVYLSPWDAHSPLYHVDREADY"
     gene            1182..2411
                     /gene="arcA"
                     /locus_tag="AC0DU4_001000"
     CDS             1182..2411
                     /gene="arcA"
                     /locus_tag="AC0DU4_001000"
                     /EC_number="3.5.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016990 - arginine deiminase activity
                     [Evidence IEA];
                     GO_process: GO:0019546 - arginine deiminase pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="arginine deiminase"
                     /protein_id="HIN4236977.1"
                     /translation="MSSHPIQVFSEIGKLKKVMLHRPGKELENLLPDYLERLLFDDIP
                     FLEDAQKEHDAFAQALRDEGIEVLYLEQLAAESLTSPEIRDQFIEEYLDEANIRDRQT
                     KVAIRELLHGIKDNQELVEKTMAGIQKVELPEIPDEAKDLTDLVESDYPFAIDPMPNL
                     YFTRDPFATIGNAVSLNHMFADTRNRETLYGKYIFKYHPIYGGKVDLVYNREEDTRIE
                     GGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKKNVGFKKVLAFEFANNRKFMHLDT
                     VFTMVDYDKFTIHPEIEGDLHVYSVTYENEKLKIVEEKGDLAELLAQNLGVEKVHLIR
                     CGGGNIVAAAREQWNDGSNTLTIAPGVVVVYDRNTVTNKILEEYGLRLIKIRGSELVR
                     GRGGPRCMSMPFEREEV"
     gene            2469..3485
                     /gene="argF"
                     /locus_tag="AC0DU4_001001"
     CDS             2469..3485
                     /gene="argF"
                     /locus_tag="AC0DU4_001001"
                     /EC_number="2.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003073325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004585 - ornithine carbamoyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0042450 - L-arginine biosynthetic process
                     via ornithine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine carbamoyltransferase"
                     /protein_id="HIN4236978.1"
                     /translation="MTNSVFQGRSFLAEKDFTRAELEYLIGLSAHLKDLKKRNIQHHY
                     LAGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRM
                     FDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVQENFGRLEGLTLV
                     YCGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEKEIVELAEGFAKESGAHVLITED
                     ADEAVKDADVLYTDVWVSMGEEDKFAERVALLKPYQVNMDLVKKAGNENLIFLHCLPA
                     FHDTHTVYGKDVAEKFGVEEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLY
                     IPKV"
     gene            3650..4597
                     /gene="arcC"
                     /locus_tag="AC0DU4_001002"
     CDS             3650..4597
                     /gene="arcC"
                     /locus_tag="AC0DU4_001002"
                     /EC_number="2.7.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003025409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008804 - carbamate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbamate kinase"
                     /protein_id="HIN4236979.1"
                     /translation="MANRKIVVALGGNAILSSDPSAKAQQEALVETAKHLVKLIKNGD
                     DLIITHGNGPQVGNLLLQHLASDSEKNPAFPLDSLVAMTEGSIGFWLKNALQNALLDE
                     GIEKNVASVVTQVVVDKNDPAFVNLSKPIGPFYSEEEAKAEAEKSGATFKEDAGRGWR
                     KVVASPKPVDIKEIETIRTLLNNGQVVVAAGGGGIPVVKENNGHLTGVEAVIDKDFAS
                     QRLAELVDADLFIVLTGVDYVFVNYNKPNQEKLEHVNVAQLEEYIKQDQFAPGSMLPK
                     VEAAIAFVNGRPEGKAVITSLENLGALIESESGTIIEKG"
     gene            4806..6317
                     /locus_tag="AC0DU4_001003"
     CDS             4806..6317
                     /locus_tag="AC0DU4_001003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004191872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YfcC family protein"
                     /protein_id="HIN4236980.1"
                     /translation="MSEKAKKGFKMPSSYTVLLIIIAIMAVLTWFIPAGAFIEGIYET
                     QPQNPQGIWDVLMAPIRAMLGTHPEEGSLIKETSAAIDVAFFILMVGGFLGIVNKTGA
                     LDVGIASIVKKYKGREKMLILVLMPLFALGGTTYGMGEETMAFYPLLVPVMMAVGFDS
                     LTGVAIILLGSQIGCLASTLNPFATGIASATAGVGTGDGIVLRLIFWVTLTALSTWFV
                     YRYADKIQKDPTKSLVYSTRKEDLKHFNVEESSSVESTLSSKQKSVLFLFVLTFILMV
                     LSFIPWTDLGVTIFDDFNAWLTGLPVIGNIVGSSTSALGTWYFPEGAMLFAFMGILIG
                     VIYGLKEDKIISSFMNGAADLLSVALIVAIARGIQVIMNDGMITDTILNWGKEGLSGL
                     SSQVFIVVTYIFYLPMSFLIPSSSGLASATMGIMAPLGEFVNVRPSLIITAYQSASGV
                     LNLIAPTSGIVMGALALGRINIGTWWKFMGKLVVAIIVVTIALLLLGTFLPFL"
     gene            6339..7670
                     /locus_tag="AC0DU4_001004"
     CDS             6339..7670
                     /locus_tag="AC0DU4_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000686986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase"
                     /protein_id="HIN4236981.1"
                     /translation="MKIDITNQVKDEFLISLKTLISYPSVLNEGENGTPFGQAIQDVL
                     EKTLEICRDIGFTTYLDPKGYYGYAEIGQGAELLAILCHLDVVPSGDEADWQTPPFEA
                     TIKDGWVFGRGVQDDKGPSLAALYAVKSLLDQGIQFKKRVRFIFGTDEETLWRCMARY
                     NTIEEQASMGFAPDSSFPLTYAEKGLLQVKLHGPGSDQLELEVGGAFNVVPDKANYQG
                     PLYEQVCNDLKEAGYDYQSTEQTVTVLGVPKHAKDASQGINAVIRLATILAPLQEHPA
                     LSFLATQAGQDGTGRQIFGDIADEPSGHLSFNVAGLMINHERSEIRIDIRTPVLTDKE
                     ELVELLTRCAQNYQLRYEEFDYLASLYVAKDSKLVSTLMQIYQEKTGDNSPAISSGGA
                     TFARTMPNCVAFGALFPGAKQTEHQANECAVLEDLYRAMDIYAEAVYRLAT"
     gene            7763..7838
                     /locus_tag="AC0DU4_001005"
                     /pseudo
     CDS             7763..7838
                     /locus_tag="AC0DU4_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(8074..8364)
                     /locus_tag="AC0DU4_001006"
     CDS             complement(8074..8364)
                     /locus_tag="AC0DU4_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000501069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005576 - extracellular region [Evidence
                     IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ZmpA/ZmpB/ZmpC family metallo-endopeptidase"
                     /protein_id="HIN4236982.1"
                     /translation="MGALGYYEGFVPYVSNQYKNQAEEEGKPLSDKYIFEKILGKTYA
                     AFKKDQINERVEKLGKLKPITINYNGKSEVIDSKEKLQELMNKAVKDEVAQI"
     gene            complement(8352..8603)
                     /locus_tag="AC0DU4_001007"
     CDS             complement(8352..8603)
                     /locus_tag="AC0DU4_001007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657761.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HIN4236983.1"
                     /translation="MKEFQFERKQRFSLRPYAIGACSVLLGTSLFFAGMGAQPVQDTE
                     TSSALISSHYLDEQDLSEKLKSELQWFELENKLLNLWEH"
     gene            8807..9010
                     /locus_tag="AC0DU4_001008"
     CDS             8807..9010
                     /locus_tag="AC0DU4_001008"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4236984.1"
                     /translation="MKIKEQTRKLATGCSKHCFEVVDKTDEVSSKHCFEVVDRTDEVS
                     SKHCFEVADRTDEVSNIYTARRR"
     gene            complement(9047..9931)
                     /locus_tag="AC0DU4_001009"
     CDS             complement(9047..9931)
                     /locus_tag="AC0DU4_001009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001838996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HIN4236985.1"
                     /translation="MIFLIVCVLLLVIVTLSTVYVVRQQSVAIIERFGKYQKVANSGI
                     HIRLPFGIDSIAARIQLRLLQSDIVVETKTKDNVFVMMNVATQYRVNEQSVTDAYYKL
                     IRPESQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQHQVAEEMTTYGYIIVKTLI
                     TKVEPDAEVKQSMNEINAAQRKRVAAQELAEADKIKIVTAAEAEAEKDRLHGVGIAQQ
                     RKAIVDGLAESITELKEANVGMTEEQIMSILLTNQYLDTLNTFASKGNQTIFLPNTPN
                     GVDDIRTQILSALRAEKK"
     gene            complement(10076..11227)
                     /locus_tag="AC0DU4_001010"
     CDS             complement(10076..11227)
                     /locus_tag="AC0DU4_001010"
                     /EC_number="1.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_function: GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HIN4236986.1"
                     /translation="MATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSD
                     ILPKTLKPLDTEGIEYVIFSDVEPNPTCKNVTDGVAALQEHGCDFIISLGGGSPQDAA
                     SCISIMATNGGKPQDYEGLHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMV
                     MVDKNSLALISVNDPELMLSKPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAI
                     ELIKEYLPRAVENGHDIEAREGMVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHG
                     VCCAMLLPVIERENAKRVPEAFRNVAKALGLHVEGKSDQECADYAIAEIEKLSETVGI
                     PKKLTELGIEEKDFDFEYLSKNALIDACAPGNPFMPTLEETIAFYKELF"
     gene            complement(11373..13139)
                     /locus_tag="AC0DU4_001011"
     CDS             complement(11373..13139)
                     /locus_tag="AC0DU4_001011"
                     /EC_number="5.3.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008736 - L-fucose isomerase activity
                     [Evidence IEA];
                     GO_function: GO:0030145 - manganese ion binding [Evidence
                     IEA];
                     GO_process: GO:0005996 - monosaccharide metabolic process
                     [Evidence IEA];
                     GO_process: GO:0019317 - fucose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-fucose isomerase"
                     /protein_id="HIN4236987.1"
                     /translation="MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLK
                     YPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIP
                     HAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEASDTDIPEDVKEKLLRY
                     ARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRS
                     IYDPEEFERALKWVKENVKEGFDHNREDLVLSREEKDRQWEFVIKMFMIGRDLMVGNP
                     RLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFAT
                     ENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVKRVTGHTLEGRAAAGFLHLINSG
                     SCTLDGTGQATRDGKPVMKPFWELEESEVQAMLENTDFPPANREYFRGGGFSTRFLTK
                     GDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGK
                     GAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSL
                     FGTEDLESADYCACQLLGPLHK"
     gene            complement(13222..16338)
                     /locus_tag="AC0DU4_001012"
     CDS             complement(13222..16338)
                     /locus_tag="AC0DU4_001012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001031112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl hydrolase family 98 C-terminal
                     domain-containing protein"
                     /protein_id="HIN4236988.1"
                     /translation="MNKEKIKRKLITILFVCIGMLCFGLLAGVKADNRVQMRTTINNE
                     SPLLLSPLYGNDNGNGLWWGNTLKGAWEAIPEDVKPYAAIELHPAKVCKPTSCIPRDT
                     KELREWYVKMLEEAQSLNIPVFLVIMSAGERNTVPPEWLDEQFQKYSVLKGVLNIENY
                     WIYNNQLAPHSAKYLEVCAKYGAHFIWHDHEKWFWETIMNDPTFFEASQKYHKNLVLA
                     TKNTPIRDDAGTDSIVSGFWLSGLCDNWGSSTDTWKWWEKHYTNTFETGRARDMRSYA
                     SEPESMIAMEMMNVYTGGGTVYNFECAAYTFMTNDVPTPAFTKGIIPFFRHAIQNPAP
                     SKEEVVNRTKAVFWNGEGRISSLNGFYQGLYSNDETMPLYNNGRYHILPVIHEKIDKE
                     KISSIFPNAKILTKNSEELSSKVNYLNSLYPKLYEGDGYAQRVGNSWYIYNSNANINK
                     NQQVMLPMYTNNTKSLSLDLTPHTYAVVKENPNNLHILLNNYRTDKTAMWALSGNFDA
                     SKSWKKEELELANWISKNYSINPVDNDFRTTTLTLKGHTGHKPQINISGDKNHYTYTE
                     NWDENTHVYTITVNHNGMVEMSINTEGTGPVSFPTPDKFNDGNLNIAYAKPTTQSSVD
                     YNGDPNRAVDGNRNGNFNSGSVTHTRADNPSWWEVDLKKMDKVGLVKIYNRTDAETQR
                     LSNFDVILYDNNRNEVAKKHVNNLSGESVSLDFKEKGARYIKVKLLTSGVPLSLAEVE
                     VFRESDGKQSEEDIDKITEDKVVSTNKVATQSSTNYEGVAALAVDGNKDGDYGHHSVT
                     HTKADSNAWWQVDLGEEFTVSKVDIYNRTDAEPQRLSNFDVIFLSSSGEEVFRRHFDK
                     VVDGLLSLKVPSVGAKLVKIELKSAAIPLSLAEVEVYGSKRTPKKLSNIALTKETRQS
                     STDYNGFSRLAVDGNKNGDYGHHSVTHTKEDSPSWWEIDLAQTEELEKLIIYNRTDAE
                     IQRLSNFDIIIYDSNDYEVFTQHIDSLESNNLSIDLKGLKGKKVRISLRSAGIPLSLA
                     EVEVYTYK"
     gene            complement(16348..18642)
                     /locus_tag="AC0DU4_001013"
     CDS             complement(16348..18642)
                     /locus_tag="AC0DU4_001013"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="HIN4236989.1"
                     /translation="MKLWYKKAASNWNEALPIGNGHLGGMIYGSATKECIQLNDETIW
                     YRGKSDRNNPDSLLHLKKIREYLLDGEIQKAEELIKLTMFATPRDQSHYELLGELYIE
                     HIDIQSCALSLYERELDLDTAISNVVFEPNSCNLQIKREYFTSFNKNILCCRIVSSVQ
                     NTLNLNINLGRNKRFNDEVSKLDSSTILMSASAGGRKGVQFKVVCHSKVTDGEVSVLG
                     ETIVIRNATEVFLYLKSMTDYWGNIDISSLQGEFSSIDYFTEKDEHVKKYQEQFNRVD
                     FKLDYSKDCLSIPTNLLLENTKKYSNYLTNLLFHYGRYLLISSSQPNGLPANLQGIWC
                     DELNPIWGSKYTININTQMNYWMVGPCDLPEVEYPLFDMLERMREPGRLTAKKMYGAR
                     GFTAHHNTDGFGDTAPQSHAMGAAIWVLTIPWLCTHIWEHYLYFQDERILTEHFEMIK
                     EAFLFFEDYLFEVDGYLMTGPSVSPENKYRLKNGIEGNACLSSTIDNQILRYFCDSCI
                     GIAKQLGDNSDFISRVKELKKKLPKTKIGSNGQIQEWLEDYEEVEPGHRHISPLFGLY
                     PYNEIDIHKTPELAEAAKITINRRLSNANFLSSQEREQAINNWLVSGLHASTQTGWSA
                     AWLIHFFARLYQGEPAYNQINGLLNNATLGNLFLDHPPFQIDGNLGLVSGICELLVQS
                     HHNWLSLIPALPSAWSEGEVKGFRVRGGYKVSFAWKNGDITFLKLEGGNKDQKVRVRI
                     YGKNTDVQNIELVFNSEKIIELNF"
     gene            complement(18701..19501)
                     /locus_tag="AC0DU4_001014"
     CDS             complement(18701..19501)
                     /locus_tag="AC0DU4_001014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HIN4236990.1"
                     /translation="MMNNKVTKVELKKVFKRSFMYGSSWNYERMQNLGFLYTILPVLK
                     KLYPDKDSASPAMKRHLEFFNTHQTAAPFILGVTSAMEEQEGNEGAASITGIKVGLMG
                     PLAGLGDSLFWLTLVPICFSIGASYSKDGGALGIFIALILFNIINIPVKYFGLKYGYT
                     KGSSLIQENNTKGTLNRVTSMATALGLVLVGGLIPSMVGINFGLEFKQGELVISVQEM
                     ITKLIPGFIPMALTLLMCKLIRKGKNPVVLIFSVMAIGVILVVLGILK"
     gene            complement(19498..20271)
                     /locus_tag="AC0DU4_001015"
     CDS             complement(19498..20271)
                     /locus_tag="AC0DU4_001015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000899624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HIN4236991.1"
                     /translation="MLFTQALLVTLVGIIATIDYNGPLFMIHRPLVTSAMVGLVLGDF
                     TQGVLIGSALELTWLGVTGIGGYTPPDTISGAIIGTAFGILSGQGETAGIAIAVPIAV
                     ATQQLDVLAKTLDVYFVKKADNDAKNGDYSKIGFYHYSSLVLITLFKIVPIFLAIMLG
                     GEYVADLFAKVPPIVMQGLNSAGALLPSIGFGMLLNMMLKKNMWVFLLIGFICSVYGG
                     MSTIGISLVGIAVAYFYDMIGSKPQETTSSSDVEEDLDL"
     gene            complement(20296..20766)
                     /locus_tag="AC0DU4_001016"
     CDS             complement(20296..20766)
                     /locus_tag="AC0DU4_001016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000020992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4236992.1"
                     /translation="MSIEFVRIDDRLVHGQVVTTWLKKYDIEQVIIVNDRISEDKTRQ
                     SILKISAPVGLKIVFFSVKRFVEVLNSVPIKKRTMLIYTNPKDVYDSIEGNLKLEYLN
                     VGQMSKTEENEKVTGGVALGEEDKYYFKKIVDKGTRVEIQMVPNDKVTMLEKFL"
     gene            complement(20757..21188)
                     /locus_tag="AC0DU4_001017"
     CDS             complement(20757..21188)
                     /locus_tag="AC0DU4_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000483177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HIN4236993.1"
                     /translation="MFNRGILVASHGNFASGALMTAEMFVGETTNDRVRTLGLMPGEN
                     IVEFEHYFKNQVDELLDSNQEVIVLTDLIGGSPNNVALSRFLNLDSVDIVTGFNIPLL
                     VELISSYDSKINLEEIVQNAQNSLFNVKQQLNVEEEEDLCL"
     gene            complement(21181..21621)
                     /locus_tag="AC0DU4_001018"
     CDS             complement(21181..21621)
                     /locus_tag="AC0DU4_001018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RbsD/FucU family protein"
                     /protein_id="HIN4236994.1"
                     /translation="MLKHIPKNISPDLLKTLMEMGHGDEIVLADANYPSASCANKLIR
                     CDGVNIPELLDSILYLMPLDSYVDSSIQFMNVVSGDDIPKIWGTYRQMIEGHGTDLKT
                     ITYLRREDFYERSKKAYAIVATGETSLYANIILKKGVVVERENV"
     gene            complement(21633..22271)
                     /locus_tag="AC0DU4_001019"
     CDS             complement(21633..22271)
                     /locus_tag="AC0DU4_001019"
                     /EC_number="4.1.2.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001286141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-fuculose-phosphate aldolase"
                     /protein_id="HIN4236995.1"
                     /translation="MSDVKQELIKYGKKLVETDLTKGTGGNLSVFDREKQLMAITPSG
                     IDFFEIKESDIVVMDINGNVVEGERLPSSEWYMHLIQYQTRDDIDAIIHAHTTYATVL
                     ACLREPLPASHYMIAVAGKDVRVAEYATYGTKELAVNAAKAMEGRRAVLLANHGILAG
                     AQNLLNAFNIVEEVEYCAKIYCLAKNFGEPVVLPDEEMDLMAEKFKTYGQRK"
     gene            complement(22386..23789)
                     /locus_tag="AC0DU4_001020"
     CDS             complement(22386..23789)
                     /locus_tag="AC0DU4_001020"
                     /EC_number="2.7.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004370 - glycerol kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008993 - rhamnulokinase activity
                     [Evidence IEA];
                     GO_process: GO:0006071 - glycerol metabolic process
                     [Evidence IEA];
                     GO_process: GO:0019301 - rhamnose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rhamnulokinase"
                     /protein_id="HIN4236996.1"
                     /translation="MEAVLAIDLGATSGRAIVGYLSENKLVMEEINRFSNLPIRVKGH
                     LSWDIDFLLAKILESIRLANTSYKILSIGIDTWGVDFGLIDNEGKLLSQPVHYRDERT
                     KGVLKEISEMTELEKLYSETGNQIMEINTLFQLFKARQESPDSFYKTNKILLMPDLFN
                     YLLTGKFATEKSIASTTQLFDPRSQNWNQNILKLFELDSSLLPEIVSEGNVLGRIKKE
                     YGLGDIPVVNVCSHDTASAIVSVPKTEGSLFISSGTWSLVGVELTSPILTTESFSYGF
                     TNEVGKDGVITFLKNCTGLWIIEELRRSFERRGKAYSFDDIRTMVEKEKENLPLIDTE
                     STEFATESDMHKTLTEYLAYHHETREWTDGQLFKIVYESLAETYRKAIELLEELTHKV
                     YKRIYVIGGGARASYFNQMIADRTGKEVLTGSTEGTAVGNIVVQLIAMGQLKGMEEAH
                     HVIEEFLQLESYYSQKN"
     gene            23965..24738
                     /locus_tag="AC0DU4_001021"
     CDS             23965..24738
                     /locus_tag="AC0DU4_001021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="HIN4236997.1"
                     /translation="MIKDERVLELIEIIKKKKRIAVKELAEITFSSTSTLRRDLIFLE
                     NQGLIKRKHGYVTLSSMNTIELSHQIREGESTRQKRLIASLAKDFIRSGMCVYLDSST
                     TVYELCPYLSELDNLIIFTNGLHTAQTLSETVKDSSKIFITSGEVKHQSCSVVNYDKE
                     NSLLDHFNIDLAFCSARGIDDQYVYEASLSQAISKKNIIDKAHETILLIDSSKFYKTG
                     FFKINPLSKYTTFISDTVPDQKLLDAVELFDGEWVSDIQ"
     gene            complement(25866..>26405)
                     /gene="adcA"
                     /locus_tag="AC0DU4_001022"
     CDS             complement(25866..>26405)
                     /gene="adcA"
                     /locus_tag="AC0DU4_001022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter substrate-binding
                     lipoprotein AdcA"
                     /protein_id="HIN4236998.1"
                     /translation="KTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYK
                     AKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTMEFVQGGQSKKYTYKYVGKKILTYK
                     KGNRGVRFLFEATDADAGQFKYVQFSDHNIAPVKAEHFHIFFGGTSQEALFEEMDNWP
                     TYYPDNLSGQEIAQEMLAH"
BASE COUNT         8009 a         5521 c         4434 g         8441 t
ORIGIN      
        1 gtagtccgct tctcggtcca catgatagag gggactatgg gcatcccacg gtgacaggta
       61 gacccccata tccatatcaa actctgtggc agcttgggat acttcaagga gcaagtcgcc
      121 ctttcctctc ctccaaggac tgaccttaac cgaataatct gtgtgagctg tcggataaag
      181 gacaaagcca tcgtggtgct tgaccaccaa aatcaacttt ttgaagcccg tttccttgag
      241 cacacgaacc cactcacgcg catccaactg actcgggtta aagcgctcag gatcctcctg
      301 tccagtcccc cattcttggt cataaaaggt attaggaccg aagtggataa aagctgctag
      361 ttcatctccc agataagcta gctgagtctg acttggtaac ggtccatgcg gtttgatttt
      421 cttcatcgtt atatatctcc ttctttagca acttctcttg ttcacaaggt tatccacagg
      481 ttgtggataa taaaaaatga tctaaccgcc agctctttcc aactccaact ggtaggctca
      541 ggatttttct cctcaatatt ccctcttcaa acagctctgt catatggttc tgctaacacc
      601 tctcagaatg ctactctcca taattattct caggcttctt tcaggtcatt gtgtgaagac
      661 cattcactct ccagactttt ccacagattg tgaataagtg attattctaa actatcatct
      721 cgtcgactat aacaaaaaat aaaaagaggg tcaataagat aattatctct tcctaaatac
      781 tcagaaaaga ttctataatt tgtacaattg aacaagaaat gcttctccaa aatctatctt
      841 caaaagaatg ttgcatcttt ttatcctttc acacaaacat ttctctttat acagatccaa
      901 gtgataacca gatgataatt ggacactttt tggttatttg tgtatttttt gaaaaatttt
      961 ttaaaaaaat tttatatcct ctttaataga agtttatgca tttgtatcta tgtattctat
     1021 cctatgttat gtataataac ataaaattgt gctaaacatc ataatttata ttattttccg
     1081 agaaattata gccattgaca ttacctagga attgcgttat aacatacatg taagcggtac
     1141 ccaaaatggt gccaagtcaa aatttttaag gaggaaaata catgtcttca catccaattc
     1201 aggtcttctc agaaattggg aaactgaaaa aagttatgtt gcaccgtcca ggcaaggagt
     1261 tagaaaactt gttgccggac tatcttgaaa ggcttctttt tgatgatatt cctttcttgg
     1321 aagatgctca aaaagaacat gatgcatttg cccaagctct tcgcgatgaa ggaattgagg
     1381 ttctctacct agaacaactc gctgctgaat cattgacctc tccagaaatc cgcgatcaat
     1441 ttatcgagga atacttagac gaagccaaca tccgtgatcg tcaaaccaag gttgctattc
     1501 gtgaattgct tcacggcatc aaggacaacc aagaattggt tgaaaaaaca atggctggga
     1561 ttcaaaaagt tgaattgcca gaaattcctg acgaagctaa agatctaact gacttagttg
     1621 aatcagatta tccatttgca attgacccga tgccaaacct ctatttcact cgcgacccat
     1681 ttgcaacaat tggaaacgcc gtatcgctta accacatgtt tgcagacact cgtaaccgtg
     1741 aaacactcta cggtaagtat atcttcaaat accacccaat ctatggcgga aaagtggatt
     1801 tggtctacaa ccgtgaagaa gatacgcgta tcgaaggtgg agacgagtta gttctttcta
     1861 aagacgtcct tgcagtaggt atctctcaac gtacagacgc agcttctatc gaaaaacttt
     1921 tggtcaacat cttcaagaaa aatgttggct tcaagaaagt tttggccttt gaatttgcta
     1981 acaaccgtaa attcatgcac ttggatactg tcttcactat ggtagactat gacaagttca
     2041 ctattcaccc agaaatcgaa ggcgaccttc acgtttactc agttacttac gaaaacgaaa
     2101 aacttaaaat cgttgaagag aaaggtgact tagctgaact tcttgctcaa aaccttggtg
     2161 tagaaaaagt tcatttgatt cgttgcggtg gtggcaatat cgtagcagct gcgcgtgaac
     2221 aatggaacga cggttctaac actttgacca tcgcacctgg tgtggtagtt gtttatgacc
     2281 gcaataccgt gaccaataag attttggaag aatacgggct tcgcttgatt aagattcgcg
     2341 gaagtgaatt ggttcggggc cgtggtggac ctcgttgtat gtctatgcca tttgaacgtg
     2401 aagaagtgta atcgctgttc ggcattcgtc aatagaaaat gtaaaaaata gaaagaggaa
     2461 ataataaaat gacaaattca gtattccaag gacgcagctt cttagcagaa aaagacttta
     2521 cccgtgcaga gttagaatac cttattggtc tttcagctca cttgaaagat ttgaaaaaac
     2581 gcaatattca acaccactac cttgctggca agaatatcgc tctcctattt gaaaaaacat
     2641 ctactcgtac tcgtgcagcc tttacaactg cggctatcga ccttggtgct cacccagaat
     2701 acctcggagc aaatgatatt cagttgggta aaaaagaatc tactgaagat actgctaaag
     2761 tattgggacg tatgtttgac gggattgaat tccgcggatt cagccaacgt atggttgaag
     2821 aattggcaga attctcaggc gttccagtat ggaacggtct aactgacgaa tggcacccaa
     2881 ctcaaatgct cgctgactac ttgactgttc aagaaaactt cggtcgcttg gaaggcttga
     2941 cattggtata ctgtggtgat ggacgtaaca acgttgccaa cagcttgctc gtaacaggtg
     3001 ctatccttgg tgtcaatgtt cacatcttct caccaaaaga actcttccca gaaaaagaaa
     3061 tcgttgaatt agcagaagga tttgctaaag aaagtggcgc acatgttctc atcactgaag
     3121 atgctgatga agcagttaaa gatgcagacg ttctttacac agacgtttgg gtatcaatgg
     3181 gtgaagaaga caaattcgca gaacgtgtag ctcttcttaa accttaccaa gtcaatatgg
     3241 acttagttaa aaaagcaggc aatgaaaact tgatcttcct acactgcttg ccagcattcc
     3301 acgatactca cactgtttat ggtaaagacg ttgctgaaaa atttggtgta gaagaaatgg
     3361 aagtaacaga cgaagtcttc cgcagcaagt acgctcgcca cttcgatcaa gcagaaaacc
     3421 gtatgcacac tatcaaagct gttatggctg ctacacttgg taacctttat attcctaaag
     3481 tataatttta gataataaac cgtctaccaa cagctatgag ggctgcgact aatagcttta
     3541 gtccggtcct cttttatata atggtaatct attatttctt ataaaatatg tgaaaaatca
     3601 ttaaattgaa atctaaacgc attctattga gtgtgataaa ggagaattta tggcaaatcg
     3661 taaaattgta gtagctttgg gaggaaatgc gattctttct tctgacccat cagcaaaggc
     3721 tcaacaagaa gctttagttg aaacagctaa gcatcttgta aaattgatta aaaatggaga
     3781 tgatctgatt atcactcacg gtaatggacc tcaagttggg aatctcttgc tccaacattt
     3841 ggcatcagac tctgaaaaga accctgcctt cccactcgac tcacttgtcg ctatgacaga
     3901 aggtagcatc ggtttctggt tgaaaaatgc tttgcaaaat gctctcttgg atgaaggcat
     3961 cgaaaaaaat gttgcctctg ttgtaacgca agttgtcgta gataaaaatg atccagcttt
     4021 tgttaacttg agtaaaccaa tcggtccttt ctattcagaa gaagaagcaa aagcagaagc
     4081 cgaaaagagc ggagcgactt tcaaggaaga tgctggccgt ggctggcgta aggtcgttgc
     4141 ctcaccaaaa cctgttgaca tcaaagaaat tgaaaccatc cgtactcttt taaataatgg
     4201 tcaagtcgtc gtagctgcag gtggtggcgg tattcccgtc gtcaaagaaa acaatggaca
     4261 tttgactggt gtcgaagcgg ttattgataa agacttcgct tcccaacgtt tggcagaatt
     4321 ggttgatgca gacctcttca tcgttttgac aggtgtagat tatgtatttg ttaactacaa
     4381 caagccaaac caggaaaaat tggaacatgt gaatgttgcc cagctggaag aatatatcaa
     4441 acaagatcag tttgcaccag gtagcatgct tccaaaagta gaagcagcta tcgcttttgt
     4501 caatggtcgt ccagaaggaa aagcagttat tacttccctt gaaaatctag gcgccttgat
     4561 tgaatctgaa agcggaacaa ttattgaaaa aggataagtt gttttactaa taagatgtat
     4621 tctatttcta gtatctttat atcaaattag aaattattct tgaaaacatg tacaatattt
     4681 caaaagatac tagttttaga ctttaatatg gtaaaacaaa tataaataga aagcgttttc
     4741 ttgaatgttt atttaagaaa gtagttggtt ttttacactt tgttagacat caggaggaaa
     4801 aacaaatgag tgaaaaagct aaaaaagggt ttaagatgcc ttcatcttac accgtattat
     4861 tgataatcat tgctattatg gcagtgctaa cttggtttat ccctgcgggg gcctttatag
     4921 aaggtattta cgagactcag cctcaaaatc cacaagggat ttgggatgtc ctcatggcac
     4981 cgattcgggc tatgctaggt actcatccag aggaaggttc gctcattaaa gaaacgagcg
     5041 cagcgattga tgtagccttc ttcatcctta tggttggtgg tttccttggc attgtcaaca
     5101 aaactggtgc tcttgacgta gggattgcct ctatcgtgaa gaagtataag ggccgcgaaa
     5161 aaatgttaat tttggtactg atgcctttgt ttgccctcgg tggtacaact tatggtatgg
     5221 gtgaagaaac aatggccttc tatccactcc ttgtgccagt tatgatggcc gttggttttg
     5281 atagcctgac tggtgttgca attattttgc tcggttctca aatcggctgt ttagcatcta
     5341 ctctgaatcc atttgcgaca ggtattgctt cagcgactgc gggagttggt acaggggacg
     5401 gtatcgtact tcgtctgatc ttctgggtta ccttgactgc tcttagtact tggtttgttt
     5461 accgttatgc ggataagatt caaaaagatc cgactaagtc actggtttat agtactcgca
     5521 aagaagattt gaaacacttt aacgtagaag aatcttcatc tgtagaatct acacttagca
     5581 gcaaacaaaa atcagttctc ttcttatttg tgttgacatt catcttgatg gtattgagct
     5641 tcattccatg gacagacctt ggcgttacca tttttgatga ctttaatgct tggttgactg
     5701 gtcttccagt tattggtaat attgtcggtt catctacttc tgcactaggt acttggtact
     5761 tcccagaagg cgcaatgctc tttgccttta tgggtatcct gattggtgtt atttatggtc
     5821 ttaaagaaga taagattatc tcttccttca tgaatggtgc tgctgacttg ctcagtgttg
     5881 ccttgatcgt agcgattgct cgtggtattc aagttatcat gaacgacggt atgattaccg
     5941 atacaatcct caactggggt aaagaaggct tgagcggtct atcttcacaa gtctttatcg
     6001 ttgtaactta tatcttctat ctacctatgt cattcttgat cccatcttca tctggtcttg
     6061 ccagcgcaac tatgggtatc atggctccac ttggagaatt tgtaaatgtc cgtcctagct
     6121 tgattatcac tgcttaccaa tctgcttcag gtgtcttgaa cttgattgca ccaacatctg
     6181 gtattgtgat gggagctctt gcacttggac gtatcaacat tggtacttgg tggaaattca
     6241 tgggcaaact cgtagtcgct attattgtag tgaccatcgc ccttcttctc cttggaacct
     6301 tccttccatt cctataaaat agtgagtgag gtgattccat gaaaatagat ataacaaatc
     6361 aagttaaaga tgaatttctt atatcattaa aaaccttgat ttcctatcct tcagtactca
     6421 atgaaggaga aaatggaaca ccttttggac aagcaatcca agatgtccta gaaaaaactt
     6481 tagagatttg tcgagacata ggtttcacta cctatcttga ccctaaaggt tattacggat
     6541 atgcagaaat cggtcaggga gcagagcttc tggccattct ctgtcatttg gatgttgttc
     6601 catcaggtga tgaagcagat tggcagacac cgccatttga agcaactatc aaagacggct
     6661 gggtattcgg acgtggtgtc caagatgata aaggcccttc gctcgcagct ctctatgcag
     6721 taaaaagctt gctggaccaa ggtattcagt tcaaaaagcg cgtacgcttt atctttggta
     6781 ccgatgagga aaccctctgg cgctgcatgg cacgctacaa taccatcgaa gaacaggcca
     6841 gcatgggctt tgcacctgac tcatcttttc ctctgaccta tgctgaaaaa gggcttctac
     6901 aggtcaaact tcatggccct ggatcggatc aactagagct tgaagtagga ggcgccttta
     6961 acgttgtacc agacaaggcc aactaccaag gtcccctcta tgaacaggtt tgtaacgatc
     7021 tcaaagaagc tggttatgat taccaatcca ctgaacaaac cgtaacggtt ctcggagtgc
     7081 caaagcatgc taaggatgct agtcaaggta tcaatgctgt catccgacta gctaccattc
     7141 ttgctcctct ccaagaacac cctgctctca gctttcttgc aacacaagca ggtcaagacg
     7201 gcacaggaag acaaatcttt ggtgatatag cagatgaacc ttctggtcac ctatccttta
     7261 atgtcgcagg tctcatgatc aatcatgaac gttctgaaat ccgtattgac attcggactc
     7321 ctgtcttaac tgataaggaa gaactagtag agttgcttac aagatgtgca caaaactacc
     7381 aactccgcta cgaagagttt gactatctag cgtctctata cgtcgcaaaa gacagtaaac
     7441 tcgttagcac actgatgcaa atctaccaag aaaagactgg cgataacagt cctgctattt
     7501 catccggtgg tgccactttt gctcgcacca tgccaaattg tgtagccttc ggcgccttat
     7561 tcccaggagc gaagcagaca gaacatcagg caaatgaatg tgccgttcta gaagatttgt
     7621 accgtgctat ggatatttat gccgaagccg tctatcgact tgcaacttaa tcaggcaact
     7681 gtttctacca aaaaaaatcc cgcaaaatga actgcacccc aaaagttaga cagaataaat
     7741 ctaacttttg gggtgtttta ttatgaaatt gagttatgaa gataaagttc agatctatga
     7801 actaagaaag caaggacaaa gcttcaaaca gctttcaaaa agatttggtg tggatgtttc
     7861 tggtctaaag tcatctgaat ctttgagatg agctttataa atcgcttttt tcagtttttg
     7921 cactggtgtt tcgataaact caaacttttt agccgtggta ttgcctgatt ttatagtata
     7981 ttgaaactag aatagtacac ctctacttct aaaacatttt tagaaatcga tttgactgtc
     8041 ctgatcgatt tatcctgttc ttatttcatt ttactatatt tgagccactt cgtctttaac
     8101 ggctttattc ataagctctt gtaatttttc tttactatca attacttctg attttccgtt
     8161 gtaatttatt gtaataggtt ttaacttacc taatttctcg acacgctcat taatttgatc
     8221 ttttttgaag gctgcatatg tttttcctaa gattttttcg aaaatatatt tatcagatag
     8281 cggtttgcct tcttcttcag cttggttttt gtattgattt gaaacataag gaacaaatcc
     8341 ttcatagtaa cctaatgctc ccataagttc aaaagcttgt tttctaattc aaaccattgc
     8401 aactcagatt tcagcttttc agataaatcc tgctcatcca aataatgact tgaaattagt
     8461 gctgaactcg tttctgtatc ctgtacaggc tgagcaccca taccagcaaa aaataaactc
     8521 gttcctagca agaccgaaca agctcctatt gcatatggcc tcaaagaaaa acgctgcttt
     8581 ctctcaaatt gaaattcttt catcccatct cccatcattc attattactg tatattttgt
     8641 atatcagaaa tagtttgtat tcacaaatct ttctagttat tcccttatca ttcctaatta
     8701 agggagataa catacaataa tttttagtta aatgtatatc gatgtttttt gtttttctta
     8761 ataaacgcaa tacaaaaaga gcctgttgcc aagctctttg tactcaatga aaatcaaaga
     8821 gcaaactagg aaactagcca caggttgctc aaaacactgt tttgaggtag tagataagac
     8881 tgacgaagtc agctcaaaac actgttttga ggttgtggat agaactgacg aagtcagctc
     8941 aaaacactgt tttgaggttg cagatagaac tgacgaagtc agtaacatct atacggcaag
     9001 gcgacgctga cgtggtttga agagattttc gaagagtatt agtctattat ttcttctcag
     9061 cgcgaagggc tgacaagatt tgtgttcgga tatcatccac accatttgga gtatttggta
     9121 aaaagatggt ttgatttcct ttagaggcaa aggtattcaa ggtatccaaa tactggttgg
     9181 tcaagaggat agacatgatt tgttcttctg tcatgccaac attggcttcc ttgagttcgg
     9241 tgatagactc tgccaatcca tccacaatcg ccttacgttg ttgggcaatc cccacaccat
     9301 gaaggcggtc tttttctgct tctgcttcag ctgcagtgac aattttaatc ttgtcagctt
     9361 ccgccaattc ttgtgctgcg acccgcttac gttgcgccgc attgatttca ttcatggatt
     9421 gcttaacttc tgcatctggt tcgaccttgg taatcaaggt tttcacgata atgtagccgt
     9481 aagtggtcat ttcttctgct acttggtgtt gaacctcaag ggcaatctca tcttttttct
     9541 caaacaattc atccaaggtt aattttggaa cagaagagcg aagagcatct tcgatataag
     9601 atttaatctg agattctgga cgtatgagtt tatagtaagc atctgtcacg ctctgctcgt
     9661 tgacacggta ctgagtcgct acattcatca taacgaacac attgtccttg gtcttagtct
     9721 caaccacaat atcactttgc aacaagcgca actgaatccg tgctgcaatc gagtcaatcc
     9781 caaaaggcaa gcgaatatga ataccgctat tagcaacctt ttggtatttc ccaaagcgtt
     9841 caataatcgc caccgactgc tgacgaacca cataaactgt actcagtgtg actatcacca
     9901 ataggagcac acaaacaatc agaaaaatca tgaaaaatat tgccataatg gaacctccac
     9961 aagtattttt ctagtattat agcacattta aagaaggctg tgccgttttt actgcgattt
    10021 ttcctgaaat gtcaataatt agaggtgaat tgtcctattg tcgtccaatc tcttgctaaa
    10081 ataactcttt ataaaaggca atcgtttctt ctaaggttgg cataaatgga tttcctggtg
    10141 cgcaggcatc aatcaaggca ttcttagaaa ggtattcaaa gtcgaaatct ttttcttcaa
    10201 taccaagttc agtcagtttc ttaggaatac ctactgtctc agaaagcttc tcaatctcag
    10261 caatcgcata atcggcacat tcttgatctg atttaccttc tacatgaagt cccaaggctt
    10321 tggcaacatt gcggaaagct tctggtacac gtttagcatt ttcacgttct ataactggta
    10381 gcaacatggc acagcacacg ccatgtggca aattatatac tgcaccgagt tggtgagcca
    10441 ttgagtgaac ataaccaaga ccagcattat taaagctcat accaccaagg aagatggcat
    10501 tgaccatacc ttcacgcgct tcaatatcat gtccattttc tacagcacga ggaagatatt
    10561 ccttgataag ctcaatagca ccaatagaca gtttcttggt tacatcataa gcaccaggtg
    10621 ttaccaaagc ttcaacagcg tgagtcagag catccatacc agtagcagca gtcaggcctt
    10681 taggtttgga aagcatgagt tccgggtcat taacagagat aagagcaagg ctattcttgt
    10741 caaccattac catcttaacc ttgcgttctt catcagtaat cacatagtta atagtgattt
    10801 ctgcagaagt tcctgccgtt gtattgatag ccacaactgg caagcctttt ttagcagact
    10861 tatgaagccc ttcataatcc tgtggttttc caccatttgt agccatgata gaaatacaac
    10921 tagctgcatc ctgtggagaa cccccgccaa gactgatgat aaagtcacag ccatgttctt
    10981 gcaaagcagc taccccatct gtgacatttt tacaagtagg gtttggctct acatcgctaa
    11041 agatgacata ttcgattcct tctgtatcca gtggttttaa agtcttaggt aaaatatcac
    11101 tgccttcgat gtacttatct gtaaccaaaa gtgccttttt atagccaagt tccttgatat
    11161 aaggacccac ttcatttaca acaccttttc caataaggtt gactgccgga acataaaatg
    11221 tagccatata attttcctcc tgcgcctccg cgctatctat ttaacatcat tatattactt
    11281 tttgtattcg tttttaatta tttgtgaatt gtttaacaaa tctttttaaa aggataggag
    11341 ggacgtaagt tcacctccta tataaacaag ttttatttat gtagtggtcc caacaactga
    11401 catgcacaat agtctgctga ttctagatct tctgttccaa ataaggacca atttttaggt
    11461 ctaaagatat cttcctcagg tacattatgc atattgacag gaattctcaa catagaagcc
    11521 aaggtaatca agtctgctcc aatgtgtcca tatgttatgg ctccgtgatt agctccccaa
    11581 ttattcatga cgtcatagac agacttgaaa gcaccttttc ctgtcaaacg tggagcaaac
    11641 caagtagttg gccatcctgg atctgtacga ttatctaaag tatggtgaac atcttcagga
    11701 agttcaagtg tataaccttc tgcaatttgt agcactggac caaccccttt tagaagattg
    11761 agacgtacca ttgttactgg catatccccc ttcgtcaaga aacgagttga gaatcctcct
    11821 ccacggaagt attcgcggtt tgctggtggg aagtctgtat tttcaagcat agcctgcact
    11881 tcactttctt ccaactccca gaatggtttc ataacaggtt tgccatctcg agtagcttga
    11941 cctgtaccat ccaatgtaca agaaccagag ttgattagat gtaagaagcc agctgcagca
    12001 cgaccctcta aagtatgtcc cgttacacgt ttaacagcct ctgggctcca ataagtacgc
    12061 acatcagcaa agatttgtgg agtatttgtt aatagataat taaagagcat agacacacca
    12121 tttagtgaat cattctctgt cgcaaataca aatggttttc gaataccatt ccagtcaaac
    12181 tgagtattga ggaaagtttc cataaaatct ccatttggaa aatggtctgt ccactgacgt
    12241 tgaccttgga aaccagctac taaagcatga tgaccaactg cttcttcctc aaaaccaagt
    12301 tcagcaagtc ttgggttacc aaccattaag tcacgtccaa tcatgaacat cttaataaca
    12361 aattcccatt gtctatcttt ttcttcacgg cttaaaacaa ggtcttcacg gttatggtcg
    12421 aatccttctt ttacgttttc tttcacccat ttgagcgcac gttcgaactc ttcagggtcg
    12481 taaatactac ggtccatacg gcgcgtgaac tccgtcatat ctaccgattc atttcgcatt
    12541 cctaggtatt cttggaagaa atccggattt acaatagaac caccaatccc catcgaaaca
    12601 ctacccattg ataggtaagc agtgtctctc atcaagccag ttgcaagagc tgcacgcgca
    12661 tagcgtaaaa gtttttcttt gacatcttct ggaatatctg tgtcactagc ttcctgaaca
    12721 tctcttccat aaatcccaaa ggctggaatc cctttttgag catgtgaagc tagtacagct
    12781 gcaagataga cagctcctgg gcgttctgtc ccattaaatc cccaaatagc atgaggaata
    12841 tctggagaca tatccatagt ttcactacca taacaccagc atggtgtaac tgtaattgtt
    12901 gcgcaaacat ttgatttttt aaacaactca tgggaagctg cagcctctgg tacacggcca
    12961 atagtagatg gagaaatcac gcattccaca ggttccccat ctggatattt caatgtgctt
    13021 gaaatcaaat ctgccacact tttagccatg ttcattgttt gcacttcaag tgattcgcgt
    13081 acaccttgac gacgaccatc aatagtcgga cgaatcccaa tacgtggatg ttgaatcata
    13141 ctattttcct cttatttttc tgtttctttc atactaccat ctccattata tttacggtag
    13201 cctgggtgat aatttttaaa attacttata agtataaacc tctacctctg ctaaacttaa
    13261 aggaattcct gcgcttctca aagaaattct aacctttttt cccttcagtc cttttaagtc
    13321 tatggataga ttattgcttt ctaaactgtc aatatgttgt gtaaaaactt cataatcatt
    13381 tgaatcatat ataataatat caaaatttga taatctctga atttcagcat ctgttctatt
    13441 ataaataatt aacttttcta attcttcggt ttgtgctaaa tctatctccc accatgaagg
    13501 agaatcttct ttggtatgag tcactgaatg atgaccataa tctccgtttt tatttccatc
    13561 aactgctaga cgagaaaaac cattgtaatc cgttgaactc tgtcgagttt cttttgttaa
    13621 tgcaatatta gaaagtttct tcggagttct ctttgaacca tagacttcaa cttccgctaa
    13681 acttaacgga atagctgctg attttaattc tattttgact agcttagccc ctacagaagg
    13741 tacttttaaa gataacaaac catcaactac tttatcaaaa tgtcttctaa aaacttcttc
    13801 tcctgatgaa gatagaaaaa taacatcaaa attagataaa cgctgaggtt cggcatctgt
    13861 tctattataa atatcaactt tagaaaccgt aaactcttct cccagatcga cctgccacca
    13921 agcgttagaa tctgccttag tatgagtcac cgaatgatgt ccgtaatctc catctttatt
    13981 accatcaact gctaaagcag ctacaccctc ataattggtt gaactttgag tagctacctt
    14041 atttgtagag actactttat cttctgttat tttatctata tcctcttcag attgcttacc
    14101 atctgattct ctaaaaacct ctacttctgc taaactcaaa ggcactccac tcgttagtaa
    14161 tttaacttta atataccttg ctcctttttc tttgaaatct agactaacag attcacccga
    14221 caaattatta acatgtttct tagcaacttc gtttctatta ttgtcatata gaatcacatc
    14281 aaaattagat agacgttgag tctcagcatc tgtgcgatta taaattttaa caagcccaac
    14341 tttatccatt tttttcaaat cgacttccca ccaagaggga ttatctgccc tagtgtgtgt
    14401 taccgaacca gagttaaaat taccatttct gttaccatcc acagctctat tagggtctcc
    14461 attgtaatct acagaacttt gtgttgttgg ttttgcatat gctatattca aattaccatc
    14521 attaaattta tctggtgttg ggaaagagac tggacctgtc ccctcagtat ttatagacat
    14581 ctctaccatt ccattatgat taaccgtaat ggtataaaca tgggtattct catcccaatt
    14641 ttctgtataa gtataatgat ttttatcgcc acttatattt atctgaggtt tatgaccagt
    14701 atgccctttt aatgtaagtg ttgttgtcct aaagtcatta tctacaggat tgatggaata
    14761 atttttgctt atccagttcg ctaactctaa ttcttctttc ttccaacttt ttgatgcatc
    14821 aaaatttcct gataatgccc acatagctgt cttatctgtc ctgtaattat tcaataaaat
    14881 atgtaaatta tttggatttt ctttaacaac agcgtaagta tgtggcgtca aatctaacga
    14941 taacgacttt gtattattag tatacatagg caacattact tgctgatttt tattgatatt
    15001 agcattacta ttataaatat accaggaatt acctacacgc tgagcatacc catctccttc
    15061 ataaagtttt ggataaagcg agtttaaata gttgacttta ctagacaatt cctcactatt
    15121 tttagtcaaa atttttgcat tagggaatat agatgaaatc ttttccttat caattttctc
    15181 atgtattaca ggaagaatat gatatctccc attattatat aaaggcattg tttcatcatt
    15241 cgaataaagt ccttgataaa atccgtttaa tgaactaatc ctaccttctc cattccaaaa
    15301 tacagctttt gttctattta caacttcttc cttacttgga gctggatttt gtatagcatg
    15361 tctaaagaaa ggaataatac ctttagtaaa tgctggagtt ggtacatcat ttgtcataaa
    15421 tgtatacgcg gcacattcga aattataaac tgtgcctccc ccagtatata cattcatcat
    15481 ttccatagca atcattgatt ctggttccga tgcataggat ctcatatccc tagctcttcc
    15541 agtttcaaat gtgtttgtat aatgtttttc ccaccatttc catgtatctg ttgatgagcc
    15601 ccagttatca cataagccac tcaaccaaaa tccactaacg atagaatctg tacccgcatc
    15661 atctcttatt ggcgtatttt tagttgccaa caccaaattt ttatgatatt tttgactcgc
    15721 ttcaaagaat gtcggatcat tcataatagt ttcccagaac catttttcat gatcatgcca
    15781 gataaaatgc gctccatatt tggcacaaac ttccaaatat ttagcactat gcggagctaa
    15841 ctggttattg taaatccaat aattctcaat atttaaaaca ccttttaaca cactatactt
    15901 ttggaattgt tcatctaacc actctggagg aactgtatta cgctctccag ccgacataat
    15961 aaccaagaaa actggaatgt ttagactttg agcttcctcc aacatcttga cataccattc
    16021 tctcaattct ttcgtatctc gtggaataca acttgttggt ttacagactt ttgcaggatg
    16081 aagttcaatc gctgcatatg gctttacatc ttcaggaata gcttcccatg ctcccttcaa
    16141 tgtgttcccc caccataatc cgttaccatt atcattgcca tacaacggag aaagcaacaa
    16201 tggcgattca ttattaatcg tcgttctcat ttgaacacga ttatcagcct taactcctgc
    16261 taacaatcca aaacataaca tcccaataca tacaaacaat attgtgatta attttctttt
    16321 tattttttct ttattcatga cttataccta aaaatttaac tcaataattt tttctgaatt
    16381 aaataccaat tcaatatttt gtacatcagt atttttgcca tatattctta ctcttacttt
    16441 ttgatctttg tttcctcctt ccaattttag gaatgttata tccccatttt tccaagcaaa
    16501 cgatacctta tatcctcctc ttactctgaa acctttcact tctccttctg accaagcaga
    16561 aggtaaagct ggaattagtg ataaccaatt atgatggctc tgtactaata attcacaaat
    16621 tccactcacc aaacctaaat taccatcaat ttgaaatggt ggatggtcaa gaaataaatt
    16681 gccaagagtc gcattattta acaaaccatt aatctggtta taagcaggtt caccttgata
    16741 tagtctcgca aaaaaatgaa tcagccatgc agcactccaa cctgtttgtg tactagcatg
    16801 caaaccactt actaaccaat tattaatcgc ttgctccctc tcctgtgaag ataaaaaatt
    16861 agcgtttgat aatctcctat tgatagtgat tttagctgct tctgctaatt ccggagtttt
    16921 atgaatatca atctcattat aaggataaag cccaaataga ggtgaaatgt gtctatgccc
    16981 aggctctact tcttcataat cttctaacca ttcttggatt tgcccattac tacctatttt
    17041 tgttttaggt agtttctttt ttaactcctt cacacgacta ataaaatccg aattgtctcc
    17101 taattgtttt gcaatgccaa tgcatgaatc acaaaaatat cttagaattt gattatcaat
    17161 tgtagatgat agacaagcat ttccttcaat accatttttt aagcgatatt tattttccgg
    17221 tgagacactt ggacctgtca tcaagtagcc atccacctca aataaataat cttcaaagaa
    17281 aagaaatgct tcttttatca tttcaaaatg ttccgtaaga atacgctcat cttggaaata
    17341 taaatagtgt tcccaaatat gagtacataa ccatggaata gttaataccc aaattgcagc
    17401 ccccatggca tgagattggg gagccgtatc gccaaaacca tccgtattat gatgtgctgt
    17461 aaaacctcta gctccataca ttttcttagc ggttagtctt cccggttctc tcattctttc
    17521 gagcatatca aataatggat attctacttc tggtaaatca catggaccta ccatccaata
    17581 attcatttga gtattaatat taatcgtata tttagaaccc caaattggat ttaattcatc
    17641 acaccatatt ccttgaagat tggcaggtaa accattcggt tgactagacg atattaacag
    17701 atatcttcca taatgaaata acaagttagt caagtagtta ctatactttt tagtgttttc
    17761 aagaagtaga ttcgttggaa tgctaagaca atctttacta tagtctagtt taaaatcaac
    17821 tctattaaat tgctcctgat atttttttac atgttcatct ttttctgtaa agtaatcaat
    17881 actactaaat tctccctgaa gagaagaaat atctatattt ccccaataat ccgtcattga
    17941 tttgagataa agaaatacct ctgtagcatt ccgaataact attgtctctc ccaatacact
    18001 tacttcacca tccgtaacct tagaatgaca tactacttta aactgaacac cttttctacc
    18061 tccagcagag gccgacatta aaattgtact tgaatccagt ttagatactt cgtcattaaa
    18121 ccgtttattt ctacccaaat taatgtttaa atttaatgtg ttttgaactg atgacactat
    18181 acggcaacat aaaatattct tattaaaact cgtaaaatat tctcttttta tttgtaaatt
    18241 acaactatta ggctcaaaca caacattaga aatagctgta tctaaatcta gctctctttc
    18301 atacaatgaa agagcacaag actgaatatc tatatgctca atgtaaagtt ccccaagtaa
    18361 ttcatagtgg ctttgatctc ttggggtagc aaacattgtt aactttatca attcttcggc
    18421 tttctgaatt tctccatcta aaagatattc ccgaattttt ttaagatgca atagtgagtc
    18481 tggattattt ctatctgact ttcctctata ccaaatagtc tcatcgttta gttgaataca
    18541 ttcttttgta gctgaaccat aaatcatacc acctaaatga ccgttcccaa tcggcaaggc
    18601 ttcattccaa tttgaggcag ctttcttata ccataatttc actctttacc tctcttccaa
    18661 aatggaggtg atatcccaaa taccacctcc acactttcta ctacttcaaa attcctaaaa
    18721 caactaggat aactccaata gccataacac taaagattag tacaaccgga ttctttcctt
    18781 ttctaattaa tttacacatt aataaagtca aagccatagg gataaatcct ggaattaatt
    18841 ttgtaatcat ttcttgaaca gaaataacaa gttccccctg cttaaattct aatccaaaat
    18901 taataccaac cattgatgga atcaaaccac ccactagtac tagccctaat gctgtcgcca
    18961 tactcgtaac gcgattcaat gttccttttg tattattttc ttggataaga ctagaaccct
    19021 tagtataccc atatttcaaa ccgaaatatt taacaggaat attaataata ttaaacaata
    19081 ttaaggcgat aaagatacct aaagcaccgc cgtctttaga ataagacgca ccaatactaa
    19141 aacagatagg aactagtgtc agccagaaca aactatctcc tagaccagcc agtggcccca
    19201 tcaagccaac tttaatacca gtaattgaag ctgcaccttc atttccttct tgttcttcca
    19261 tagcggaagt aactccaaga ataaatggtg ccgctgtttg atgagtattg aaaaactcaa
    19321 ggtgacgttt cattgcagga gaagctgaat ctttgtctgg gtatagtttt ttcaatactg
    19381 gaagaattgt atatagaaaa cctaggttct gcattctctc atagttccat gaagaaccat
    19441 acataaaact tcgtttgaaa acttttttaa gttcaacttt agttacttta ttattcatca
    19501 tagatcaaga tcctcctcaa catcactact tgaagttgtt tcttgtggtt tacttccaat
    19561 catatcgtag aagtatgcta ccgcaatacc aactagtgag atcccaatgg ttgacattcc
    19621 tccatacaca gaacaaatga atccaatcaa caagaatacc cacatatttt tcttgagcat
    19681 catatttaaa agcataccaa aaccaattga aggtagtaaa gcacctgcag agttaagtcc
    19741 ctgcataacg attggtggaa ccttagcaaa caagtctgcc acatattccc ctccaagcat
    19801 aatagctagg aaaattggta caattttaaa taacgtgatt aaaaccaaac ttgaataatg
    19861 ataaaaaccg atctttgaat aatctccgtt tttagcatca ttatcagctt ttttcacaaa
    19921 ataaacatct aaagtttttg caagaacatc caactgttgg gtagcaactg caattggaac
    19981 tgctatagcg ataccagcag tttctccttg accagataaa ataccaaatg cagtaccaat
    20041 aatcgcacct gaaatagtat ctggtggagt gtaacctcca atacctgtta caccgagcca
    20101 agttaattca agagctgaac caataagaac accttgggtg aaatctccta agactaagcc
    20161 aaccattgca cttgtaacta acggacggtg aatcataaat aacggtccat tatagtcaat
    20221 agtggcaata atcccaacta atgtcaccag taatgcttgt gtgaatagca tatactgtac
    20281 ctccttaaat tatttttata aaaatttttc caacattgta actttatcat taggaaccat
    20341 ttgaatttca actctcgttc ccttatcaac tattttctta aaataatatt tgtcttcttc
    20401 acctagagct acacctcccg ttaccttttc attttcctcc gttttactca tctgtcctac
    20461 attgaggtac tccaatttta aatttccttc aatagaatca tacacatctt ttggatttgt
    20521 atatatcagc attgttctct tttttattgg cacagagttt aaaacttcca caaaccgttt
    20581 tacactaaag aaaacaattt ttaaacctac cggtgcagaa atctttaaaa tagattgtcg
    20641 tgttttatct tctgagatgc gatcattaac aatgataact tgctcaatat catacttttt
    20701 tagccacgta gtgacaactt gaccatgtac cagacggtca tcaatacgaa caaactctat
    20761 agacataaat cctcttcctc ctctacgtta agttgttgtt taacattaaa caaactattt
    20821 tgagcatttt gaacaatttc ttctaaattg atttttgaat cataacttga tattaattcc
    20881 actaggagag ggatattaaa ccctgttaca atatcaactg aatccaaatt taaaaaccgt
    20941 gacaaagcca cattattagg acttcctcca atcaagtcag tcaaaacgat aacctcttga
    21001 tttgagtcta acagttcatc cacttgattt ttaaaataat gttcaaactc tacaatattc
    21061 tctccaggca tcaaacctaa tgtcctaact ctatcatttg ttgtctcacc aacaaacatt
    21121 tctgcggtca tgagagctcc gctagcaaaa ttaccatgac tggcaactaa aattcctcta
    21181 ttaaacattt tctctttcaa caactactcc tttcttaagg ataatattag cataaagtga
    21241 agtttctcct gtagcaacaa tagcataagc tttcttacta cgttcataaa agtcttctct
    21301 tctaagataa gtaatcgttt taagatctgt accatgacct tcaatcatct gtctataggt
    21361 accccatatc ttaggaatat catcacccga aacaacgttc ataaactgaa ttgaactatc
    21421 gacgtaacta tctaatggca ttaaatacag aatggaatct aataattctg gaatatttac
    21481 gccatcacaa cgaattagct tatttgcaca tgaggcagaa ggataattcg cgtcagctaa
    21541 tactatttca tctccatgtc ccatttccat taaagtcttc aataaatctg gagaaatatt
    21601 tttcggtata tgttttaaca ttaatatcct ccctattttc tctgaccgta tgttttaaat
    21661 ttttctgcca ttaaatccat ctcctcatca ggaagaacta ctggctctcc aaaattctta
    21721 gctaaacaat aaatttttgc acaatattca acttcttcaa caatattaaa tgcattcaat
    21781 aaattttgtg cacctgctaa aattccatga ttcgctagta aaactgctct acgaccttcc
    21841 attgctttag ctgcattcac agccaattct ttcgtaccat atgttgcata ctcagctacc
    21901 cgaacatctt tccctgccac tgcaatcata taatgactag ccggaagtgg ttctctgaga
    21961 caagctaata ctgttgcata agttgtatga gcatggataa ttgcatcgat atcatcacga
    22021 gtttgatatt gaatcaaatg catataccat tcgctagatg gcaagcgttc tccctctaca
    22081 acatttccat taatatccat cactacaata tcggattctt tgatttcaaa gaaatcaata
    22141 cccgacgggg taattgccat caattgtttt tcacgatcga aaacactgag attcccacct
    22201 gttcctttcg tcaaatctgt ttctactagc ttcttgccat acttaattaa ttcttgtttt
    22261 acatctgaca ttcttgtcct cctcatatca aaacactaaa tatttttcaa ttcaccaatt
    22321 atcccccctt cttgtacaaa acttaggaag ggggagggag gcaaatttac aaactctcaa
    22381 tctttttaat tcttttggga gtaataactc tctaattgta gaaactcctc aataacatgg
    22441 tgagcttctt ccatcccttt taattgtccc atagctatga gctgcacaac aatattcccc
    22501 acagctgtac cctcagtcga acctgtaaga acctctttac cagttctatc agcaatcatt
    22561 tggttaaagt aactggctct agcacctcct ccaatcacat atatcctctt ataaacctta
    22621 tgagttagtt cttctagtaa ctctatcgct ttcctatacg tttcagctag gctttcataa
    22681 acaatcttaa atagttgtcc atctgtccac tctctagttt catgatgata agctagatat
    22741 tctgtcaaag tcttgtgcat atcagattct gttgcaaatt cagttgattc agtatcaatc
    22801 agaggaagat tttctttttc tttctccacc attgtcctaa tatcatcaaa agaataggct
    22861 ttccctcttc gttcaaatga acgtcttagt tcctctatga tccacaaccc tgtacaattc
    22921 ttcagaaatg taatcactcc atctttaccg acttcatttg taaatccata actgaaggat
    22981 tcggtagtaa gaatcggtga agtaagttcc actccaacca aagaccaagt acctgatgaa
    23041 ataaataaac taccttctgt cttaggtact gagacaatcg cacttgctgt atcatgacta
    23101 caaacattca caacaggaat atcgcctaaa ccatactcct tttttatcct tccaagaaca
    23161 tttccctctg aaacaatttc aggaagtaaa gatgaatcca attcaaatag ttttaagata
    23221 ttctgattcc aattttgact cctaggatca aataattgag ttgttgaagc aatgcttttt
    23281 tctgtagcaa acttacctgt caagagataa ttaaacaaat ctggcattaa aagaatctta
    23341 ttggtcttat agaaagagtc aggagattct tgacgtgcct taaagagttg aaacaaggta
    23401 tttatctcca taatctgatt tcctgtctct gaatacagtt tttctaattc agtcatttca
    23461 gatatttcct ttaacactcc ctttgttctt tcatcacgat aatgaacagg ttgtgataac
    23521 agcttacctt cattatcaat cagtccaaaa tcaactcccc atgtgtcaat accgatagat
    23581 aaaatcttgt aactagtatt agccaagcgg atactttcaa gaattttagc tagtagaaag
    23641 tcaatatccc aagataaatg cccttttact ctaataggta gattagaaaa gcgatttatt
    23701 tcttccatta ctagtttatt ttcagaaagg taaccaacga ttgctcttcc agaagtcgca
    23761 cctaaatcta ttgctaaaac cgcttccatt tttcttctct cttcgtcctt gattaagttt
    23821 attataatcc ccacatttta ttttttcaat atgtgaacgc ttacttggat aatgttcaaa
    23881 tgttaaccca atattcataa aaataattca aattcctcca atttgtgcta taatatagtt
    23941 gaaatgataa attaggagga gcttatgata aaagatgaac gtgtacttga attgattgaa
    24001 attattaaaa agaaaaaaag aattgccgta aaagagctgg cagaaatcac tttctccagc
    24061 acaagtacct tacgtcgtga tttaattttc ttagaaaatc aaggtcttat caaaagaaag
    24121 cacggatacg tgaccctgtc ctctatgaac acaattgaac tttctcatca aatacgggaa
    24181 ggagaaagta ctaggcaaaa aagactaatc gctagtctcg ctaaagactt tattcggtca
    24241 ggtatgtgtg tttatctgga ttccagtacg actgtctacg aactttgtcc ctatctttct
    24301 gaacttgata atttgattat ttttacaaat ggtttacata ctgcacaaac cctatctgaa
    24361 actgttaaag atagctccaa aatctttatc acatctggcg aggtcaaaca tcaatcctgt
    24421 tccgtggtca attacgataa ggaaaattct ttattagatc attttaatat cgatttagca
    24481 ttttgttcag caagaggtat tgatgaccaa tatgtttatg aagcttctct cagccaagct
    24541 atttcaaaaa agaatattat tgacaaagcc catgaaacca tcttactgat tgatagctct
    24601 aaattttaca agactggatt ttttaaaatt aatcccctat ccaaatacac aacctttatt
    24661 tctgacaccg tgccagatca aaaattatta gacgcagtcg aattatttga tggagaatgg
    24721 gtttctgata ttcaatgaaa atcaaatagg aagctagtct cagcttgctc aaagtacaga
    24781 tttgaaaact gatgaagtca agtcccccat ggacacggca agacgaagct gacatgatgt
    24841 gaagagattt tcgaagaata ctcgttctgt ctgctgactg atttacaaat attcaccaca
    24901 tgacattatt ttcttagcaa ccctaaaaac agaggctgga caaaaactca atttcaagag
    24961 aaatggggca aatattccca caataaaacg catagtatca agtttttgca cacctgatat
    25021 tatgcgtttt tctgatttta aagactttgt cgcctagacc ctatatttca agaattaagt
    25081 gaccttgatg atctaaatgt attgtggtat actatttttg tcatcggtta ccgattacgt
    25141 tcctatgggt tcgtgagagg aggtgaaact aatgagcctt atcatagagc tcgctcttac
    25201 tattatagcg gatgttatag ctggaattat cttgtatttc atctgcagat ggctagatag
    25261 taaggagtag accgaatgac tagcctataa acacccgtta aatctctaag atacgtcaaa
    25321 aaagccctta actacggcca tagttagggg ctttggtgtt ctaatgaacc ttatcaatta
    25381 actacatttt agcatataat ctacaatagt tcaagcatta agtgaggttg atgatctaaa
    25441 tttagtgtgg tatactattt ttgtcatcgg ttaccgatta cgttcctatg ggttcgtgag
    25501 aggaggtgaa actaatgagc cttataccag agcttgctct tactattata gcagatgtta
    25561 tagctggaat tatcttgtat ttcgtctgca aatggctaga tggtaagaag tagaccgact
    25621 gactagccta taaacacccg ttaaatcact aagatacgtc aaaaaagccc ttaactatgg
    25681 cactagttag gggctttggt gttctaatga accttataca ctaactacat tctagcatat
    25741 aagtcctaat atttcaagag ttttatttat tttttcaggt tcccttagtt ctgaaaggtc
    25801 tataatgaag ttagccatct agtatcaaaa aaccgactag ctcttatgaa ctagtcgatt
    25861 tctcatcaat gcgccaacat ttcttgggcg atttcttggc cagataggtt atctgggtag
    25921 taggttggcc agttgtccat ttcttcaaag agggcttctt ggcttgtgcc tccaaagaag
    25981 atatggaaat gttctgcctt aactggggcg atattgtggt cactaaactg aacatacttg
    26041 aattgtccag cgtcagcatc tgtggcttca aagaggaaac gcacgccacg attgcctttc
    26101 ttgtaagtca aaattttctt accgacatac ttgtaagtgt atttcttgct ttgtccacct
    26161 tgaacaaatt ccatagtatt atcagtaatg ttaatcttag tcacatctgt ctgatagcct
    26221 tttgtatagt aagccttgta ctcagcctgg gtcatcttac cagtcaactt agccttgtag
    26281 tcaaagactt ggtcaaacgt gccgtcttca aggaaaggat aaactgattg ccagttacct
    26341 gcatagtcac tcaaggtgcg gtccttgaca gctgcatcct cgaagtaacc attttggact
    26401 gtctt
//
LOCUS       DBMVGT010000022        25181 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.022, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000022 DBMVGT010000000
VERSION     DBMVGT010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 25181)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25181)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..25181
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.022"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(462..1442)
                     /locus_tag="AC0DU4_001023"
     CDS             complement(462..1442)
                     /locus_tag="AC0DU4_001023"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0052689 - carboxylic ester hydrolase
                     activity [Evidence IEA];
                     GO_process: GO:0045493 - xylan catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acetylxylan esterase"
                     /protein_id="HIN4236999.1"
                     /translation="MKNPALLEEIKTYRGRDEVPEDFDAFWDGEVKNVSTPPSYHLEE
                     RDFHIPQVKCYELTFEGSKEGKVYARIVLPKSEEKVPLIFHFHGYMGRGWDWADMLGF
                     TVAGYGVVSMDVRGQSGYSQDGLRSPLGNTVKGHIIRGAMEGRDHLFYKDVYLDIYQL
                     VEIVASLSQVDEKRLSSYGASQGGALALVAAALNPRIQKTVAIYPFLSDFRRVIEIGN
                     TSEAYDELFRYFKFHDPFHETEEEIMATLAYIDVKNLAHRIQGEVKMITGLDDDVCYP
                     ITQFAIYNRLTCDKTYRIMPEYAHEAMNVFVNDQVYNWLCGSEIPFKYLK"
     gene            complement(1758..3773)
                     /gene="recG"
                     /locus_tag="AC0DU4_001024"
     CDS             complement(1758..3773)
                     /gene="recG"
                     /locus_tag="AC0DU4_001024"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HIN4237000.1"
                     /translation="MNLHQPLHVLPGVGPKSAEKYAKLGIENLQDLLLYFPFRYEDFK
                     TKQVLELEDGEKAVLSGQVVTPASVQYYGFKRNRLRFSLKQGEVVFAVNFFNQPYLAD
                     KIELGATLAVFGKWDRAKASLTGMKVLAQVEDDLQPVYRLAQGISQASLVKVIKTAFD
                     QGLDLLIEENLPQSLLDKYKLMSRCQAVRAMHFPKDLAEYKQALRRIKFEELFYFQMQ
                     LQTLKSENRVQGSGLVLDWSQEKVTAVKASLPFALTQAQEKSLQEILTDMKSDHHMNR
                     LLQGDVGSGKTVVAGLAMFAAVTAGYQAALMVPTEILAEQHFESLQNLFPNLKLALLT
                     GSLKAAEKREVLETIAKGEADLIIGTHALIQDGVEYARLGLIIIDEQHRFGVGQRRIL
                     REKGDNPDVLMMTATPIPRTLAITAFGDMDVSIIDQMPAGRKPIVTRWIKHEQLPQVL
                     TWLEGEIQKGSQAYVISPLIEESEALDLKNAIALSEELTTHFAGKAEVALLHGRMKSD
                     EKDQIMQDFKERKTDILVSTTVIEVGVNVPNATVMIIMDADRFGLSQLHQLRGRVGRG
                     DKQSYAVLVANPKTDSGKDRMRIMTETTNGFVLAEEDLKMRGSGEIFGTRQSGLPEFQ
                     VADIIEDFPILEEARKVASYISSIEAWQEDPEWRMIALHLEKKEHLD"
     gene            complement(3792..4895)
                     /gene="alr"
                     /locus_tag="AC0DU4_001025"
     CDS             complement(3792..4895)
                     /gene="alr"
                     /locus_tag="AC0DU4_001025"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000648075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008784 - alanine racemase activity
                     [Evidence IEA];
                     GO_process: GO:0006522 - alanine metabolic process
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HIN4237001.1"
                     /translation="MKASPHRPTKALIHLGAIRQNIQQMGAHIPQGTLKLAVVKANAY
                     GHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFT
                     LTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVRVE
                     GIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVR
                     MGDAMYGLNPSGAVLDLPYDLIPALTLESALVHVKTVPAGACMGYGATYQADSEQVIA
                     TVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKLYPLGTKVTLIGSNG
                     DKEITATQVATYRVTINYEVVCLLSDRIPREYY"
     gene            complement(4885..5247)
                     /gene="acpS"
                     /locus_tag="AC0DU4_001026"
     CDS             complement(4885..5247)
                     /gene="acpS"
                     /locus_tag="AC0DU4_001026"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA];
                     GO_process: GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HIN4237002.1"
                     /translation="MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGR
                     RQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLSIS
                     HTDQFVTASVILEENHES"
     gene            complement(5292..6323)
                     /locus_tag="AC0DU4_001027"
     CDS             complement(5292..6323)
                     /locus_tag="AC0DU4_001027"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HIN4237003.1"
                     /translation="MAFIEKGQEIDMEVIKAETQLSAEALRLKESRDRELADIISGED
                     DRILLVIGPCSSDNEEAVLEYARRLSALQKKVADKIFMVMRVYTAKPRTNGDGYKGLV
                     HQPDTSKAPSLINGLQAVRQLHYRVITETGLTTADEMLYPSNLILVDDLVSYHAVGAR
                     SVEDQEHRFVASGIDAPVGMKNPTSGNLGVMFNAIYAAQNKQTFLYHGQEVETSGNPL
                     AHVILRGAVNEYGNYMPNYYYENLLQAIERYETMELENPFILIDTNHDNSGKQYMEQI
                     RIVRQTLQNRDWNEKIKKTVRGFMIESYLADGRQNQPEVFGCSITDPCLGWENTEALV
                     EEIYVTLTK"
     gene            complement(6325..7356)
                     /locus_tag="AC0DU4_001028"
     CDS             complement(6325..7356)
                     /locus_tag="AC0DU4_001028"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000232189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HIN4237004.1"
                     /translation="MVFTAKSSKINIEEVRALSKLEGQALERKSQRDQELEAIIRGED
                     QRILLVIGPCSSDNEEAVLEYAKRLAVLQEEVADRIFMVMRVYTAKPRTNGDGYKGLI
                     HQPNATEAPSLINGIKAVRHLHYRVITETGMTTADEMLYPENLPLVDDLISYMAVGAR
                     SVEDQQHRFVASGAGFSTGFKNPTSGNLNVMFNGIYAAQNKQSFLFLGKEVETTGNPL
                     SHAILRGALNEYGKNIPNYYYDNLIDTIAQYEKMGLENPFIIIDTNHDNSGKQYIEQI
                     RIVRQTLINRAWNEKIKQFVRGFMIESYLEDGRQNEPEVFGKSITDPCLGWDNTEALV
                     REIYKTLGE"
     gene            complement(7437..9950)
                     /gene="secA"
                     /locus_tag="AC0DU4_001029"
     CDS             complement(7437..9950)
                     /gene="secA"
                     /locus_tag="AC0DU4_001029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HIN4237005.1"
                     /translation="MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAK
                     TVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRT
                     GEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKS
                     PMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEAR
                     TPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLE
                     NLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGL
                     HQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIP
                     IPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKL
                     VAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCV
                     IGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSE
                     EAIESRMLTRQVEAAQKRVEGNNYDTRKQVLQYDDVMREQREIIYAQRYDVITADRDL
                     APEIQSMIKRTIERVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAI
                     KEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLR
                     GYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRN
                     IAAHQASMPEDLDLSQIGRNELCPCGSGKKFKNCHGKRQ"
     gene            complement(10096..10383)
                     /locus_tag="AC0DU4_001030"
     CDS             complement(10096..10383)
                     /locus_tag="AC0DU4_001030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000940707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237006.1"
                     /translation="MAHLKSFITRYSKVYIGLVLLIWLTFFFIPWDRAILGVRIDIFI
                     IQKILLAFGILSILMALLSKKVSLFVFGLICCLSLWINLFITFAILPIFGN"
     gene            complement(10394..11044)
                     /locus_tag="AC0DU4_001031"
     CDS             complement(10394..11044)
                     /locus_tag="AC0DU4_001031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4237007.1"
                     /translation="MRLEIINGQKIYGKRPILNQLNLVFQSGKIYGLKGNNGSGKTVL
                     LKILAGYIKLDKGKVLQDGKVYGVKNHYIQDAGILIEKVEFLSHLSLRENLELLRYFS
                     SKVTEKRIAYWIQYYDLQEFEDVEYRHLSLGTKQKMALIQAFISSPSILFLDEPMNAL
                     DEKSVRLTKQVILSYLKKENGLVILTSHISKDISDLCTDVLAVENGHIQYVKDIQS"
     gene            complement(11048..11689)
                     /locus_tag="AC0DU4_001032"
     CDS             complement(11048..11689)
                     /locus_tag="AC0DU4_001032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000475766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237008.1"
                     /translation="MFKNFNNILLKRKIVLLLRIVLMMILINHLLSTAVQKQDAVIFF
                     KRELISIFSYNDYSEVNLEIPKLLLNLSLFMVGWLSVILLESDLADHYHHLIRYQSSS
                     FFDYTRKRLVVISKFFTQDLFVWFLGLLPLGIHFKTVALFFLLAQLMMLYLLLSYLIA
                     LISAGAGFSFFLYFLAFVGQEWMMDHIVTVYLVLLSLLVMLILSRLEEKFKKG"
     gene            complement(11682..12473)
                     /locus_tag="AC0DU4_001033"
     CDS             complement(11682..12473)
                     /locus_tag="AC0DU4_001033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237009.1"
                     /translation="MKIPLLTLARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDL
                     AKFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIIIVLLGFQYIELKNKVLRLSIG
                     REVSYQGLKRKLTLQVASIPCLIYLVTVLIIAILTHFFGTFSPLGWNSLFSDGSSLQR
                     LLDGEITSYLFFTCVLLIGIFINAVYFLQIVDYLGNVTRSAITYLMFLWLGSMLLYSA
                     LPYYMVPMTSLMQASYGDVSLMKLFTPYILYIVPYMVLEKYEDNV"
     gene            complement(12658..12993)
                     /locus_tag="AC0DU4_001034"
     CDS             complement(12658..12993)
                     /locus_tag="AC0DU4_001034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237010.1"
                     /translation="MEHLFKMIILLPCFYFFSWIDKDNRESKFFPIFYYFYWIYITLY
                     ALFSLAWTVFSVLFFNIVLRNVADIKLWGIWLLLLLIAFASDWLDYICFKKMLDLRRE
                     LGKSKGGRH"
     gene            complement(13133..13468)
                     /locus_tag="AC0DU4_001035"
     CDS             complement(13133..13468)
                     /locus_tag="AC0DU4_001035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237011.1"
                     /translation="MEHLFKFLLLAPYFYFDNWIEKANRNSKFFPIFYYFYWFYIPFY
                     SLFSLAWTVVSVLFFNTVLRNVTDIKLWGIWFLFILLAIGMNWLTYSCFKEMFRLRQE
                     LGKSKGGRH"
     gene            complement(13559..14869)
                     /gene="der"
                     /locus_tag="AC0DU4_001036"
     CDS             complement(13559..14869)
                     /gene="der"
                     /locus_tag="AC0DU4_001036"
                     /EC_number="3.6.5.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HIN4237012.1"
                     /translation="MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYA
                     TGEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEY
                     VARKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIV
                     ENLPNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFT
                     DTDGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDK
                     RIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQ
                     RLHKLPEMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKP
                     PTFVIFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK"
     gene            complement(14883..15596)
                     /locus_tag="AC0DU4_001037"
     CDS             complement(14883..15596)
                     /locus_tag="AC0DU4_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent oxidoreductase"
                     /protein_id="HIN4237013.1"
                     /translation="MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQ
                     SYSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFVGDLNRAEKGARLHTDTFQPQGVE
                     GLLISSVDAALAGQNALLAAESLGYGGVIIGLVRYKSEEVAELFNLPDYTYSVFGMAL
                     GVPNQHHDMKPRLPLENVVFEEEYQEQSTEAIQAYDRVQADYAGARATTSWSQRLAEQ
                     FGQAEPSSTRKNLEQKKLL"
     gene            complement(15593..16489)
                     /gene="dnaI"
                     /locus_tag="AC0DU4_001038"
     CDS             complement(15593..16489)
                     /gene="dnaI"
                     /locus_tag="AC0DU4_001038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein DnaI"
                     /protein_id="HIN4237014.1"
                     /translation="MESVGDVLKRQPSRFHYQDLVQKIMKDPDVAAFVQQESLNQDEL
                     NRSISKFNQYITERDKFLRGDTDYIAKGYKPILVMNHGYADVSYEETPELIAAEKEAA
                     IKKRLNLINFPSSLKNVSFLDVYRDDVQRLTVLKRMIEFVNDYPNNLKGLYLYGDFGV
                     GKSFMVAALAHDLSEKRGVSSTLLHYPSFVIDVKNAISDGNVKTLVDEIKLSEVLILD
                     DIGAEQSTVWVRDEILQVILQYRMQENLPTFFTSNFNFEDLEKHFAKVKHGNDETWEA
                     RRVMERIRYLAEETRLEGVNRR"
     gene            complement(16490..17659)
                     /locus_tag="AC0DU4_001039"
     CDS             complement(16490..17659)
                     /locus_tag="AC0DU4_001039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain protein"
                     /protein_id="HIN4237015.1"
                     /translation="MKPIDRFSYLKNNRVSQDTSSLVQCYLPIIGQEALSLYLYTISF
                     WDNGRKEYLFSSILNHLNFGMDRLIKSLKILSAFNLLTLYQKGDVYQLVLHAPLSSQD
                     FLEHPVYRRLLEKKIGDVAVEDLKVESADGEEIPVSLNQVFPELAELGSQEDLGLKKK
                     VANDFDLDHFRQLMARDGLRFADEQSDVLNLFAIAEEKKWTWFETYQLAKSTAVSQVI
                     STKRMREKIAQKPVSSDFSLKETTIIKEAKSKTALQFLAEIKQTRKGTITQTERELLQ
                     QMAGLGLLDEVINIILLLTFNKVDSANINEKYAMKVANDYAYQKIHSAEKAVLRIRER
                     EQKAKTQKQNQTAPAKTNIPKWSNPEYKNTSSAEELEEMERQTLELLAKLDNGGD"
     gene            complement(17660..18133)
                     /gene="nrdR"
                     /locus_tag="AC0DU4_001040"
     CDS             complement(17660..18133)
                     /gene="nrdR"
                     /locus_tag="AC0DU4_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001203675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0140110 - transcription regulator activity
                     [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator NrdR"
                     /protein_id="HIN4237016.1"
                     /translation="MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERV
                     EERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENE
                     IQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER"
     gene            18273..18638
                     /locus_tag="AC0DU4_001041"
     CDS             18273..18638
                     /locus_tag="AC0DU4_001041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HIN4237017.1"
                     /translation="MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEA
                     GVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQSRKQLSEEELEHFVSSMTH
                     FGYEKEELPGVVSDYIKGV"
     gene            18643..19338
                     /locus_tag="AC0DU4_001042"
     CDS             18643..19338
                     /locus_tag="AC0DU4_001042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237018.1"
                     /translation="MSLLAFENVSKSYGATPALENVSLDIPAGKIVGLLGPNGSGKTT
                     LIKLINGLLQPDQGRVLINDMDPSPATKAVVAYLPDTTYLNEQMKVKEALTYFKTFYK
                     DFNLERAHHLLADLGIDENSRLKKLSKGNKEKVQLILVMSRDARLYVLDEPIGGVDPA
                     ARAYILNTIINNYSPTSTVLISTHLISDIEPILDEIVFLKDGKVVRQGNVDDIRYESG
                     ESIDQLFRQEFKA"
     gene            19355..20122
                     /locus_tag="AC0DU4_001043"
     CDS             19355..20122
                     /locus_tag="AC0DU4_001043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000498762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237019.1"
                     /translation="MFWNLVHYEFKNVNKWYLALYAAVLVLSALIGIQTQGFKNLPYQ
                     ESQATMLLFLATVFGGLMLTLAISTIFLIIKRFKGSVYDRQGYLTLTLPVSEHHIITA
                     KLIGAFIWSLISTAVLALSAVIILALTAPEWIPLSYVITFVETHLPQIFLTGISFLLN
                     TISGILCIYLAISIGQLFNEYRTALAVAAYIGIQIVIGFIELFFNLSSNFYVNSLVGL
                     NDHFYMGAGIAIVKELIFIAIFYLGTYYILRNKVNLL"
     gene            complement(20475..21674)
                     /locus_tag="AC0DU4_001044"
     CDS             complement(20475..21674)
                     /locus_tag="AC0DU4_001044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237020.1"
                     /translation="MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHIQGS
                     SMAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDEASAKEAIKEEKLKGYLTIDQEDSV
                     LKAVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDEA
                     KENKKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYA
                     RMMALFLVILTHIGIYVVGGLAAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISL
                     FMYVVLAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALGAAGDNLLLKIGSYIPF
                     ISTFFMPFRTINGYAGGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTF
                     KRALSYK"
     gene            complement(21671..22564)
                     /locus_tag="AC0DU4_001045"
     CDS             complement(21671..22564)
                     /locus_tag="AC0DU4_001045"
                     /EC_number="7.4.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237021.1"
                     /translation="MLEVRSLEKSFGSKQVLFGIDFQARPGRILGLVGKNGAGKTTIF
                     HSILKFLEYQGEIGLDGQDIRQETYARIGYLPEERSLMPKLTVLEQVRYLATLKGMDA
                     KEVKEKLPQWMKRLEVKGKLTDKIKSLSKGNQQKIQLIITLIHEPDLIILDEPFSGLD
                     PVNTELLKQVIFQEKERGATIIFSDHVMTNVEELCDDILMIRDGRVVLHGPVQDVRNQ
                     YGKTRLFVSSERSKEELENLPHVKQVSLTKQGSWKLILEDESAGRELFPILTQGQYIA
                     TFDQQAPTIDEIFKLESGVEV"
     gene            22686..22877
                     /locus_tag="AC0DU4_001046"
     CDS             22686..22877
                     /locus_tag="AC0DU4_001046"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237022.1"
                     /translation="MKSKERTRKLAVGCSKYSFEVADKTDEVSSKHCFEVVDRTDEVS
                     NYIYGKAKLTWFEEIFEEY"
     gene            23270..23458
                     /locus_tag="AC0DU4_001047"
                     /pseudo
     CDS             23270..23458
                     /locus_tag="AC0DU4_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558115.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            23873..24490
                     /locus_tag="AC0DU4_001048"
     CDS             23873..24490
                     /locus_tag="AC0DU4_001048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HIN4237023.1"
                     /translation="MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQS
                     KETLSAFIQQAGIWGPPLFIFLQILQTVVPIIPGALTSVAGVFIYGHIIGTIYNYIGI
                     VIGCAIIFYLVRLYGAAFVQSVVSKRTYDKYIGWLDKGNRFDRFFIFMMIWPISPADF
                     LCMLAALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQML"
     gene            complement(24810..>25181)
                     /locus_tag="AC0DU4_001049"
     CDS             complement(24810..>25181)
                     /locus_tag="AC0DU4_001049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HIN4237024.1"
                     /translation="FKGVCPFHKGCLEGYAAGPSLEARTGVRGENIELNNPVWDVQAY
                     YIAQAAVNATVTFRPDVIVFGGGVMAQQHMLDRVREKFTSLLNGYLPVPDVRDYIVTP
                     AVAGNGSATLGNFVLAKEVSK"
BASE COUNT         7416 a         5602 c         4680 g         7483 t
ORIGIN      
        1 gttttgaggt tgtggataga actgacgaag tcagctcaaa acactgtttt gaggttgtgg
       61 atagaactga cgaagtcagt aaccatacct acggcaaggc gaagctgacg tggtttgaag
      121 agatttttga aaagtattaa cacctacaga caagcctaac gatagcaaga actaccctac
      181 tcgataggta tcggcttttg ctttctgaaa aaaattattt taagcaattt gacaaatcta
      241 gcaacaaaaa attctataaa tataatagat tgaaactaga atagtacaca tctacttcta
      301 aaacattgtt agaaatcgat ttgactgtcc tgatcgattt gtcctattct tgtttcattt
      361 tactatattt ccatgataaa acgcatagta tcaagttttt ttaatcccct gatactatgc
      421 gtgtttgtaa tttttaagat tttgtgctta gagtcgactc cttattttag atatttaaaa
      481 ggaatctcac ttccacagag ccagttgtag acttggtcat tgacaaatac attcatggct
      541 tcgtgagcat actcaggcat gatacgatag gttttatcgc aggtcagacg attataaatc
      601 gcaaactggg taatgggata gcaaacatcg tcgtccaagc ccgtaatcat cttaacctca
      661 ccttggatac gatgggcaag atttttgaca tcgatatagg caagggtcgc catgatttcc
      721 tcctctgttt catggaaggg gtcgtgaaac ttgaaataac ggaaaagttc gtcgtaagcc
      781 tcgctagtat taccaatctc aatcacccgt ctgaagtctg acaagaaggg ataaatggca
      841 actgttttct gaattcgagg attgagcgct gctgcaacta gagctagagc ccctccttgt
      901 gaggcaccat agctagaaag acgcttctca tcaacctgag acagactagc aacaatttcg
      961 accaactggt aaatatccag ataaacatcc ttataaaaga ggtggtcccg accttccata
     1021 gcaccacgga taatatgccc cttcacggta tttcctaaag gagaacgcaa gccgtcttgt
     1081 gagtaacctg actggccccg cacatccatg gaaacaacac cataaccagc tacggtgaag
     1141 cccagcatgt cggcccagtc ccagccacgt cccatataac catgaaaatg gaagattagt
     1201 ggaaccttct cctcactctt tggaagaaca atgcgtgcat agacctttcc ttccttgctt
     1261 ccttcaaatg ttaactcata gcacttgact tgaggaatgt ggaaatctct ttcctccaag
     1321 tggtaggatg gaggtgtgga aacatttttc acttccccat cccagaaagc atcaaagtct
     1381 tccggaacct catcccttcc tctataggtc ttaatttctt ctagcaaagc tggatttttc
     1441 atagcatgct ccttttattt tgtaatcgtt accacaactg tagcatatct atgtaatcaa
     1501 tgcaagaaag aaggataaat agaaagtgaa tttagattct ttacttttag gatgatgggc
     1561 tgaaagtagt tttagaaacg aaaaagagca tttcgctctc tcttctgttt atactagttt
     1621 tttgcttcct tcttttggaa agtggtttgg taatttactt taatcgttac tgtcatatga
     1681 gagtcctcgt ttctttttga tgactttagt ataagagcca aacctaaaaa ctagcttaag
     1741 ttttccttag agaaagctta atccagatgt tctttctttt ccagatgaag ggcaatcatg
     1801 cgccactctg gatcttcttg ccaagcttct atagaactaa tgtagctagc aacctttctt
     1861 gcttcttcta aaatcggaaa atcttcgata atatcagcca cttggaactc tggaagtcct
     1921 gactgtctgg ttccaaaaat ctcaccagaa ccacgcattt tcaaatcttc ctccgcaagg
     1981 acaaatccat tggtcgtttc tgtcatgatg cgcatgcggt ctttcccaga atccgtcttg
     2041 ggattggcaa cgagaacagc gtaggactgc ttgtcccccc gaccgacacg acctctaagc
     2101 tggtgaagtt gactgagacc gaagcgatcg gcatccatga taatcatgac agtcgcattg
     2161 ggaacgttga ccccaacctc aataaccgtc gtcgaaacca gaatatccgt ctttctctcc
     2221 ttgaaatcct gcatgatctg gtctttttcg tcactcttca tcctaccatg tagaagagcc
     2281 acctctgcct tgcctgcaaa atgagtcgtc aactcctctg ataaggcaat ggcatttttc
     2341 aaatctagag cttctgattc ttcaatcaaa ggagagatga cataggcttg ggaacctttt
     2401 tgaatttccc cctctaacca agtcaagacc tgaggtagtt gctcatgttt gatccagcgc
     2461 gtcacaatag gcttccgacc tgctggcatc tggtcgataa tggaaacatc catatctcca
     2521 aaggctgtga tggcaagcgt ccgtggaatg ggagtcgccg tcatcatgag gacatctgga
     2581 ttgtcacctt tttcccgtaa aatacgcctt tgccctacac caaaacggtg ctgctcatcg
     2641 ataataatca aaccaagacg agcatactcc accccatctt gtatcagagc gtgagttcct
     2701 ataatcaaat cagcctcacc cttggcaatg gtctccaaga cttctctctt ttctgcagct
     2761 ttcaaggaac ctgtcaagag agccagtttc aaattgggaa aaaggttctg taaactctca
     2821 aagtgttgct ctgcgaggat ttctgttggt accattaggg cagcctgata acctgctgtc
     2881 actgccgcaa acatggccaa gccagcgact accgtttttc cactccccac atctccttgt
     2941 aggagacgat tcatgtggtg gtcggacttc atatcagtta aaatttcctg caaactcttt
     3001 tcctgagctt gggtcagggc aaaaggaaga cttgctttaa ctgctgtcac tttttcctga
     3061 gaccaatcca gaaccagacc acttccctga actctatttt cagacttgag cgtctgcagc
     3121 tgcatttgga aataaaagag ttcctcaaac ttgatacggc gaagagcctg cttgtattct
     3181 gccaaatcct ttggaaaatg catagctcgg actgcctgac aacgggacat gagtttgtat
     3241 ttgtctagta aagactgggg cagattttct tctatcaaga ggtccagtcc ctgatcaaaa
     3301 gccgtcttga tgaccttgac cagactggcc tgactgattc cctgagccag acgatagaca
     3361 ggctggaggt catcttctac ctgagccaga accttcatcc cagtcagact agccttagcg
     3421 cggtcccatt ttccaaagac agcaagggtt gctcccaact ctattttatc agccagatag
     3481 ggctggttaa agaaattcac cgcaaaaacg acctctccct gcttgagact aaaacgcagg
     3541 cgattgcgct tgaaaccata atactggaca ctagcaggag tcactacctg accagaaaga
     3601 actgccttct caccgtcttc cagctccagc acctgcttgg ttttgaagtc ttcataacgg
     3661 aaaggaaagt agagcaagag atcttgcaag ttttcaattc ctagtttggc gtatttttct
     3721 gctgactttg gtcccacacc aggcaagaca tgcaagggtt gatgtagatt catgctccac
     3781 tcctttcttt tctaataata ttctctcgga atacggtcgc tgaggaggca aaccacctca
     3841 tagttaatgg ttacgcggta ggtcgctacc tgagttgcag tgatttcctt atccccattg
     3901 gagccaatca aggttacctt ggttcctagc ggataaagct taggcaatcg aatagtgatt
     3961 tggtccatcg aaaccctgcc gacaattggg caagcttggc catctaccaa gacagagaaa
     4021 ttttgcatgt ctcttgtcca tccatctgca tacccgattg gcacggtcgc gatgacttgc
     4081 tcgctatccg cttgataagt tgctccatag cccatgcaag ctccagctgg aactgtcttg
     4141 acatgaacca gagcagactc caaggtcaag gccggtatca aatcataagg caaatccaag
     4201 accgctccac ttggattgag gccatacatg gcatctccca tacgaaccgc attgaaaata
     4261 gtctctacat gccaaagagt cgttgcagaa ttgctagcat gaaccagctc tggaacttcc
     4321 ttcatactag ctaaaatagt tttaaaccgt tctaactggg cattaaaata gtcatctgat
     4381 tcctcatcag cagtagcaaa gtgggtaaag attccttcaa cacgaacacc gtgttgttgt
     4441 agcaaatctt gagcctgctc aacctcactg gcctctctaa aaccaatccg tcccatccct
     4501 gaatcaatct tgaggtggac tgtcaatcca gttaggtcca cttccttatc taagagtgct
     4561 tgaatccact ccagtccagc cactgtcaag gtgaagtcat attctttagc tagagcaaca
     4621 gcttcgattt cagaaactcc taaaatgagg attggcttgc tgagtccagc ttgtctgagt
     4681 tcaatggctt catcgatatt ggaaacgcaa aagccatcaa catcatcttg aattgccttg
     4741 gcaacggcaa cagctccatg accataagca ttggccttga ccacagccaa cttgagcgtt
     4801 ccttgaggga tatgagcccc catttgctga atattttgtc gaatagctcc cagatgaatc
     4861 agagccttgg ttggtctatg tggactagct ttcatgattt tcctccaaaa tgacactggc
     4921 tgtcacaaac tgatcggtgt ggctgataga cagccaaatc tttcctgaaa atggtgcctg
     4981 actaaaataa ggcgccccac gttcattgtt caagacttcc aaatcctgaa aaccgagctt
     5041 gctaatgccc gttcccatag ccttggaaaa ggcctcctta gccgaccagc gaccagctaa
     5101 atattctatt tgcctgcgtc ctttgagact ggtgaagcgc tccatttcct gagcggtcag
     5161 tacacgctta gcaaatcctt catgtcgtgt aactgcgctt tctatcgaag ccaattcttc
     5221 gatgtcaatt ccgtgtccaa ctatcattct catcaaaagg agttgagatt ccccaactcc
     5281 atccttttca cttattttgt caaggtaaca taaatctctt ctaccaaggc ctctgtattt
     5341 tcccaaccta ggcaagggtc agtaatagag caaccaaaga cctctggttg gttttgacga
     5401 ccatctgcta ggtaagattc aatcataaat cctcgaaccg tctttttaat tttctcattc
     5461 caatcacgat tctgcaaggt ctggcgaaca attcgaatct gctccatata ttgcttgcct
     5521 gagttatcat ggttggtgtc aatgaggata aaaggatttt caagttccat ggtttcatag
     5581 cgttcaatgg cttggagtag gttttcatag tagtaattcg gcatataatt gccatactcg
     5641 ttgactgctc cacggaggat aacatgggcc aaaggattac ctgatgtctc aacttcctgc
     5701 ccatgataaa ggaaggtttg cttgttttga gcagcataga tggcgttaaa cataacaccc
     5761 aaatttcctg aggttggatt tttcatccct actggtgcat caatcccaga agccacaaag
     5821 cggtgctctt ggtcttccac agaacgagct ccaacggcat ggtagctgac caagtcatcc
     5881 accaagatca gatttgacgg ataaagcatc tcatctgccg ttgtcaaacc agtctctgta
     5941 atcacgcggt agtgcaactg gcgcacagcc tgcaagccgt taatcaggct tggagcctta
     6001 gaagtatctg gctggtgaac caatccttta tagccgtctc cattggtacg aggcttagca
     6061 gtatacacgc gcatgaccat gaaaatcttg tccgctacct tcttttgcaa ggcggataaa
     6121 cggcgagcat attccaagac cgcctcttca ttatcagaag agcaaggacc aatcaccaag
     6181 agaatacggt catcttcccc tgaaataata tctgccaatt ccctgtcacg gctttccttg
     6241 agtctcaagg cttccgcaga caattgggtt tcagccttga tgacttccat atcgatttct
     6301 tgaccttttt caataaatgc catcttattc tcctaacgtt ttgtaaattt ctctgacaag
     6361 agcttctgtg ttatcccaac ccaggcaagg gtctgtgata gacttaccaa atacttctgg
     6421 ctcattttgt cgaccatctt ccagataaga ctcaatcata aaaccacgaa cgaactgctt
     6481 aattttttca ttccaagcac ggttaatcaa ggtctggcgg acaattcgga tctgttcaat
     6541 atactgctta ccagaattgt catgattggt atcaatgatg ataaaaggat tttccaagcc
     6601 cattttctca tactgggcaa tggtatcaat taaattgtca taatagtagt tgggaatatt
     6661 ttttccatac tcattaagag caccacgaag aatagcgtgt gaaagcgggt tcccagttgt
     6721 ttctacttct tttcctaaga aaaggaaact ttgtttgttt tgagcagcat aaatcccatt
     6781 aaacatgaca ttgagatttc cagaggttgg atttttaaaa ccagtagaaa atcctgcccc
     6841 acttgccaca aagcggtgtt gctggtcttc aactgaacgg gcaccaactg ccatgtaaga
     6901 aatcaaatca tctacaagcg gaaggttttc aggataaagc atttcatcag cagttgtcat
     6961 ccctgtttct gtgatgacac gatagtgaag atggcgaacg gctttgattc cattgataag
     7021 actaggcgct tctgtcgcgt taggctggtg aatcaagccc ttatagccat ctccgttggt
     7081 acggggtttg gcagtataaa cacgcataac cataaagata cgatctgcca cttcttcttg
     7141 taggactgcc aaacgcttag cgtattcaag gacagcttct tcgttgtcag atgagcatgg
     7201 cccgattacc aagagaattc gctggtcttc tccacgtata atggcttcta gctcttgatc
     7261 tcgctgtgat ttcctctcca aagcctgacc ttctaatttt gacaaggcac gaacttcttc
     7321 tatatttatt ttagagcttt ttgctgtaaa taccataact catctcctta taaagcaaac
     7381 ggatacccag taaaaattta cttttcacaa gatatccgcc tctaaactat ctcattttat
     7441 tgtcttttac cgtgacagtt tttaaatttc ttaccagaac cacatgggca aagttcattg
     7501 cgtccaatct ggctcaaatc caaatcttct ggcatacttg cttggtgagc agcgatattg
     7561 cgagtcgctg ttgtactgat atgacgttct gcctgtggtc tttcttgttc atgaatttgt
     7621 gctttcatca tcaagcgtgt cacatcaaac tcaatcgaac caatcatatc attaaacata
     7681 cggaaacctt ctgcctgata ctcaacaaca gggttgttct gagcatagcc acgaagtcca
     7741 accgcgttac gcaattgatc aagggcatcg atatgatctg tccacttgtt atccaccact
     7801 cgtagaatca aaactttttg gaattcttta actgcttctt catcgcgtag ttttgaaacc
     7861 tgactatcgt aaaccttcaa ggcacgttgg aaaagctctt ccttgatggc cttatcagac
     7921 aagcctgaca agtcttccat cgtaatagaa tcttcaggaa gcaagttgta cttagcaaag
     7981 ttcaaaattg cctctagttt ttcatcttgt ttggcacgcg catgaccatc aacgacacgt
     8041 tcaatcgtgc gtttgatcat agactgaatt tcaggtgcca agtcacgatc tgcagtgatg
     8101 acatcgtaac gttgagcata gataatctca cgttgttcac gcatgacatc atcgtattga
     8161 aggacttgtt tacgggtatc gtagttattt ccttcgacac gtttctgagc tgcttcaacc
     8221 tgacgcgtca acatgcgaga ctcaatcgcc tcttcagaca tgttcaagcg ttcaaagatt
     8281 cccttcaagc gttcagaacc aaaacgtttc atcaaatcat cttcaagaga taggtagaat
     8341 tgtgactcac ctggatctcc ttgacgacct gaacgtccac gaagctggtt atcgatacga
     8401 cgactttcat gacgttctgt accaataaca caaagtcctc caagttcacg aacaccttca
     8461 ccaagcttga tgtcggtacc acgacccgcc atgttggttg cgatggtaac ggcaccacgt
     8521 tgaccagcat tcatgatgat ttgggcttct ctatagtggt ttttggcatt caagacttcg
     8581 tgaggaacac cagctgcaac caatttctta gaaatgtagt cactagtttc aaccgctact
     8641 gtaccaacca agacaggttg acccttttgg taacgagcct taacgtcttc gacaaccgct
     8701 ttaaacttag attctatact tgcataaaga aggtctgagt ggtcaatacg ttgaacagga
     8761 cggtttgttg ggattggaat aacacgaatg ttgtagattt cacggaattc ttcttcctca
     8821 gtcttacctg tacccgtcat accagacaat ttcttgtaca tacggaaaag gttttggtac
     8881 gtgattgagg cagatgtctt ggtttcatcc tggattggca caccttcttt ggcttcaata
     8941 gcttggtgca atccatcaga ataacgacga ccttccatgg tacgacctgt aaattggtcg
     9001 acaatcaaga tttcttgctc ttcgctcacc acatagtcaa tatcgagaag catgatgtag
     9061 ttggcacgaa gggcgttatc gataaagtgg gtcaaagcca cgttttcgat gtcatagagg
     9121 ttttcaagtt tgaagtagct ttcagccctg tcaatccctg aatcagacaa accaatagtc
     9181 ttagactgca catcgatgat gtagtcatct ttgttcaaag attttacata gtggtctgcc
     9241 atgtgataca actgactggt ttcaaccgca ttggcacctg atacaatcaa aggtgtacga
     9301 gcctcgtcaa tcaagataga gtcaacctca tcgaccaagg catagttaag cggacgttgt
     9361 accatgtttt cagcgcgaac gaccatattg tcacgaaggt agtcaaatcc gatttctgag
     9421 ttagttgagt aagtaatatc acactcatag gcttcttttt tctccattgg agatttggta
     9481 gccaagttaa tccctactga caaaccaagc caagagtaca attcacccat ctcagtcgcg
     9541 tcacgttctg acaggtattc attaaccgta actacgtgaa cccctttacc tgaaagggca
     9601 ttgaggtata ccggcatggt cgcagtcaag gttttccctt cccctgtacg catctctggc
     9661 acgtcaccat ggtgaagaac aatccccccc atgacctgaa ccttataagg gaagagacct
     9721 aggacacgtt tggcaccttc acggacaacc gcaaatgctt cgtaaagcaa tgaatccagt
     9781 gattctccat tttgataacg ttccttaaat tcaactgttt ttgcttttag ttggtcgtca
     9841 gtcaaagcag ccatttggtc ttcgtatttg aaaaccttgt cagccatctt ttccagacga
     9901 cggatttctc ctttatcatt ttcgataatt gtttttaaaa tattagccat gtttttcctt
     9961 actttaaatt ccgaatattt tagaatgttc ctttaatttt agcacaatta ctgattattt
    10021 tcaaggaaga atccccattt tgaaaaggaa aaagaggtta gttttcaagc taacctctcc
    10081 gacttttatg atgctttaat tgccaaaaat cggcaaaatg gcaaatgtga taaataagtt
    10141 aatccaaaga gaaagacagc aaatcagtcc aaaaacaaag agactgactt tcttggacag
    10201 caaggccatc aaaatggaca gaattccaaa agctagcaag attttctgta tgatgaagat
    10261 gtcaatcctt acccccagaa tcgctctatc ccaagggata aagaagaaag tcagccagat
    10321 cagcagaact aaaccaatat aaaccttgga atagcgtgta ataaatgatt ttagatgtgc
    10381 cataagccat ctcctaggat tgtatatcct ttacatattg tatatgtcca ttttcgacag
    10441 ctaatacatc tgtacaaagg tctgaaatat ctttcgatat gtgcgacgtc aggataacca
    10501 gaccattttc ttttttcagg taagataaaa tgacctgttt ggttaacctc acactcttct
    10561 catccaaagc attcataggt tcatcgagaa agagtataga aggagaggaa ataaaggctt
    10621 gaatcaaggc cattttttgc tttgttccca aggataaatg acggtattca acgtcttcaa
    10681 attcctgtaa atcatagtat tgaatccaat aggcaattct tttttccgta actttagatg
    10741 aaaaatacct taacagttcc aaattttctc tcagggataa atgagataaa aactcgactt
    10801 tttcaattaa aattcctgca tcctgaatat aatgattttt taccccgtaa actttaccat
    10861 cttgaagaac ttttcctttg tcaagcttaa tataaccagc aagtatcttt aaaagaaccg
    10921 tcttgccaga tccattatta cctttaagtc cataaatttt tcctgattga aacaccaaat
    10981 tcaactgatt taaaataggt cttttcccat aaattttctg tccatttata atttcaagtc
    11041 tcatcgttta tcctttctta aatttctctt ccaagcgact aagaatcaac ataactaata
    11101 agcttaagag tactaaatac actgttacaa tatgatccat catccattct tgtcccacaa
    11161 atgccaaaaa atagagaaaa aaagaaaaac cagcgcccgc actaatcagt gctatcagat
    11221 aagacagtag taagtacaac atcattaact gagcaagtaa aaagaaaagt gcgactgttt
    11281 tgaaatgaat tcctagagga agtaaaccaa gaaaccagac aaacaaatct tgagtaaaaa
    11341 atttagaaat gacaaccaat cgtttccttg tataatcgaa aaaggagctt gattgatagc
    11401 gaatcaagtg atggtaatgg tctgccaaat cactttcaag taaaatgaca gagagccatc
    11461 ctaccatgaa aagcgaaagg tttaacaaga gtttggggat ttctaaattc acttcagaat
    11521 agtcattata ggaaaaaatt gaaatcaatt ctctcttgaa aaagataaca gcatcctgct
    11581 tttgaaccgc tgttgacaat agatggttta tcaaaatcat catcagaact atacgaagta
    11641 gtaaaacaat ctttctcttt agcaaaatat tgttaaaatt cttaaacatt atcttcatat
    11701 ttttcaagca ccatgtaagg gacaatataa aggatataag gagtaaagag tttcatcaaa
    11761 cttacatccc catagctagc ttgcatcaaa ctcgtcatag gaaccatata gtaaggcaag
    11821 gcactataga gcagcataga accaagccaa agaaacatca aataggtgat tgccgaacga
    11881 gtcacatttc ctaaataatc aactatttgt aaaaaataga ctgcattgat gaaaataccg
    11941 attagtagga cacaagtaaa gaacaaatag cttgttatct ctccatctag gagcctttgt
    12001 aaactactcc catcagaaaa tagagaattc catccaagag gagaaaaagt cccaaagaaa
    12061 tgagttaaaa ttgcaattat cagcacagtc actaaatata tcaaacaagg gatacttgca
    12121 acttgcaaag tcaactttct ttttaaccct tgataactca cttctcttcc aatactcaat
    12181 cgtaaaactt tatttttcag ctcaatatat tgaaaaccta gcaaaacaat gatgattgga
    12241 ataataaatg attgataaaa acctagattg aactggagaa tacgaaaatc taatgctgat
    12301 tttaataagt catttttaat tgcttgtcca tcgaatttag ctagatcggg cgcatgaata
    12361 tcaaaaaaga aataagtcat caaaacatca cgataaacca aagcaagaaa aagcaaagta
    12421 agcaagacat aaacaaattt atgccttgcc aaagttaaga gaggaatctt cataagccac
    12481 ctcctacaaa tagaaagtaa tataatactc aatgaaaatc aaagagcaaa ctaggaaact
    12541 agccgcaagt tgctcaaagc actgctttga ggttgtagat aagactgacg aagtcagtta
    12601 catatataat ccaaggcgac gttgacgtgg tttgaagaga ttttcgaaga gtataaatca
    12661 atgccttccg cctttagact tccctagttc ccgtctcaag tcaagcattt ttttgaaaca
    12721 gatatagtct aaccagtcac tagcaaaagc gataagtagt aataatagcc aaatacccca
    12781 taacttgatg tctgccacat ttctcaagac gatattgaaa aacagaactg aaaaaactgt
    12841 ccaagcaagg ctaaaaagag catagagggt gatgtaaatc cagtaaaaat agtaaaaaat
    12901 tgggaaaaat ttactttctc tattatcctt gtcaatccag ctgaaaaagt aaaaacaggg
    12961 taataagatt atcattttaa acaagtgttc catcacaagc ctcctttttt aaattgtttt
    13021 ctttagtttc gttctattaa atgttattac caatataaac cttggaatag cgtgtaataa
    13081 atgattttag aggtaccata agccacctcc tacaaataga aaccgatata aatcaatgcc
    13141 ttccaccctt agacttccct agttcctgtc tcaagcgaaa catttctttg aaacaggaat
    13201 aagttaacca attcatacca atagctagca gaataaaaag aaaccaaatg ccccataact
    13261 tgatatctgt cacatttctc aagacggtat tgaaaaacag aactgaaaca actgtccaag
    13321 caaggctaaa aagagaatag aaggggatgt aaaaccagta aaaataataa aaaattggaa
    13381 aaaacttact atttctgttg gccttctcaa tccagttatc aaaataaaag tacggtgcta
    13441 aaagtaagaa tttaaacaaa tgttccatca ccgacatcac cctccttctt ttgatagcgt
    13501 tttctattat tttattatat caaaaaaatc cggaactgtc attccagatt ctactttttt
    13561 atttgcgttt tcttgcgatg agatgaatcg gtgttccctc aaaaacaaag gccttgcgga
    13621 tttgattttc caagaaacgc aggtaagaaa agtgcatgag ttcttcttca ttgacaaaga
    13681 tgacaaaggt tggtggtttg gttgccactt gggtcgcata gaaaatcttg agacgttttc
    13741 ctttgtctgt cggtgttggg ttgatggcaa tggcatccat gatgacatcg ttcaagacag
    13801 ctgatggaat acgtgtattt tgactttcgc tgatttgctt aatcatctca ggaagtttgt
    13861 ggagacgttg cttggttaaa gctgatacaa agataatcgg tgcgtaaggc aggtattgga
    13921 actgctcacg gatatcttct tcccagtttt tcatagtgtg gttatctttt tcaagcgtat
    13981 cccacttgtt gaccacgata atcatccctt taccagcttc atgggcaaat cctgcgatac
    14041 gcttgtcgta ctcacgaatg ccttcttccg cattgatgac catcaagacc acatctgaac
    14101 ggtcaatagc acgcatggca cgcataacag agtatttctc agtattttca taaaccttac
    14161 cagacttacg cataccagcc gtatcaatca tggtaaactc ttgaccatct gtatctgtaa
    14221 agtgggtatc aatggcatca cgagttgttc cagcaacagg actagcaata acacggtctt
    14281 ctcccaagat agcattgatc aagcttgatt ttccaacgtt aggacgacca atcaagctaa
    14341 acttaatgac atctggattt tcttcctcat attcatttgg aagattttct acgatcgcat
    14401 ctagcacatc ccctgtaccg attccatgga cagatgagat aggcaatggt tcacccaaac
    14461 cgagagcata gaaatcatag atatcatttc tcatctcagg gttgtccacc ttgttgactg
    14521 cgaggataac tggtttgtgg gtcttataaa gcttacgagc tacgtattcg tctgcatcag
    14581 taattccttc cttaccagac acgacaaaaa cgataacatc tgcttcttcc atggcaattt
    14641 ctgcctggtg cttgatttgt tccatgaaag gagcatcgac atcatcaatt cctcctgtat
    14701 caatcatgct aaaagaacga ttgagccact cacccgttgc ataaatacgg tcacgtgtca
    14761 ctccttcgac atcttctaca atggagattc gctcaccagc gatccgatta aatagggttg
    14821 atttcccaac attgggacgt cctacaatgg caatagttgg tagggccata atttctcact
    14881 ttctacaata atttcttctg ttcaagattt tttctagttg agcttggttc agcttgacca
    14941 aactgttctg ctaggcgctg actccagctt gtggtcgcac gcgccccagc atagtcagcc
    15001 tgaacacggt cataagcttg gattgcctca gttgactgtt cttggtattc ttcctcaaag
    15061 acaacattct ctagtggcag tcttggtttc atatcatgat gttgatttgg cacacccagt
    15121 gccatcccaa agacagaata ggtgtagtca ggtaggttaa agagctctgc cacttcttca
    15181 gacttgtatc gaaccaaacc gataatcaca ccaccatagc ccaagctttc agctgccaac
    15241 aaggcgtttt gtccagcaag agctgcatcg accgaactaa tcaagagacc ttccacacct
    15301 tggggttgga aggtgtcggt atgaagtcgg gctccctttt ctgctcggtt caaatctccg
    15361 acaaagagaa ggaaaacagc agactggcga atggcttctt gaggtaccaa ttcatacaag
    15421 gcatctttct tctcttgact tcgtaccaca atcacagagt aggattggaa attcttccaa
    15481 gatgatgcca tctgggctgc tgtcaaaatc tcatttaagt ctacttgggg aatttcttgc
    15541 tctttaaacc tgcgcactga agtatgagcc ttcatcaatt taatggtttc tgtcatcgac
    15601 ggtttactcc ttctaaacga gtctcctcag ccaaataacg gatgcgttcc atgacccgtc
    15661 tggcttccca ggtttcgtca tttccatgtt tcactttcgc aaaatgcttc tccaaatctt
    15721 caaagttgaa gttggatgtg aaaaaggtcg gtaaattttc ctgcatccga tattggagaa
    15781 tgacctgcag gatttcgtca cgcacccaaa cggttgattg ctcggcgcca atatcatcta
    15841 aaatcaggac ctcagacagc ttaatctcat ccaccaaggt cttaacattg ccatcactga
    15901 tagcattttt gacatcaatg acaaagctag gatagtggag gagagtggat gatacaccac
    15961 gtttttctga taaatcatga gctagggcag ccaccatgaa acttttaccc acaccaaagt
    16021 ctccatacaa gtaaagacct ttcaaattat tggggtaatc gttaacaaat tctatcattc
    16081 tttttagaac agttaagcgc tgaacatcat cacgataaac atctaaaaaa ctgacatttt
    16141 tcaggctaga tggaaaatta attaagttga gacgtttctt gatagccgct tctttttcag
    16201 ctgcgattag ttcaggagtt tcttcataag aaacatctgc atagccatgg ttcatgacta
    16261 atataggctt gtagcctttg gcaatataat ctgtatctcc tcggaggaat ttatctctct
    16321 cagtgatgta ttggttaaac ttggaaatac tacggttcaa ctcgtcctga ttgagggatt
    16381 cttgctggac aaaggccgca acatcaggat ccttcatgat tttctgaact aaatcttgat
    16441 agtgaaaacg acttggttga cgtttgagta catctccgac actttccatc taatcacctc
    16501 cgttatctaa ttttgctaat aattctaggg tttggcgttc catctcttct aattcctcag
    16561 cggatgacgt atttttatat tcaggattac tccatttagg aatattggtt tttgctgggg
    16621 cagtctgatt ctgtttttgt gtttttgctt tctgttctcg ctcacggatg cgcaagactg
    16681 ccttttctgc cgaatgaatc ttttgatagg catagtcatt ggctaccttc atggcatatt
    16741 tctcattgat atttgccgaa tcgaccttat taaaggtcaa taaaagaatg atattgatga
    16801 cttcgtccag caagcccaag ccagccatct gttgcaagag ttctctttct gtttgggtaa
    16861 tggttccctt gcgtgtttgc ttgatttctg ccaagaactg cagggcagtt ttacttttgg
    16921 cttctttgat aatggttgtt tccttaagac taaagtcaga ggaaactggt ttttgagcaa
    16981 ttttttcccg catgcgtttg gttgaaataa cctgagaaac agctgttgac ttggccaatt
    17041 gataggtttc aaaccaagtc catttcttct cctcggcaat agcaaagagg tttaagacat
    17101 cggactgctc atccgcaaaa cgaagtccat ctcgagccat cagctggcga aaatggtcca
    17161 agtcaaaatc gttggccact ttcttcttga gaccaaggtc ttcttgactg cctagttctg
    17221 ccaattctgg aaagacttga ttgagtgaga caggtatttc ttcaccatca gcactttcaa
    17281 ctttcaaatc ctccacagct acatcgccaa tctttttctc taagagtctg cgataaacag
    17341 gatgctccaa gaagtcttga ctagatagag gagcatggag gactagctga taaacatccc
    17401 ccttttgata gagggtcaag agattaaaag cagataagat tttcaatgat tttatcagtc
    17461 tatccatccc aaagttaaga tggttgagaa tgcttgaaaa aagatattcc tttctaccat
    17521 tatcccaaaa actgattgta taaagataaa ggctcagtgc ctcctgaccg ataatcggga
    17581 ggtagcactg taccagagat gaggtatctt gcgacacccg attattcttt agataagaaa
    17641 aacggtcaat tggcttcatt tatctttcct ttttcttttt agaggactgg gtgatttgtt
    17701 ggagcaagct ctctaactca ctgacatcct taaaactacg atagacacta gcaaaacgta
    17761 cataggtaat ctcgtccaat tcagccaact cctccatgac gagtgaacca atgtcctcac
    17821 tttgaatttc attttcattt cgaccacgga gtttctgttc gatacgattg actaccatgt
    17881 tgatttcatc acttgacaca ggacgtttct gggctgagcg gataatccca ttaaagattt
    17941 tatctctgga gaattgttcc cgtgtgccat cttttttaac aaccactaag gttctttctt
    18001 ctactcgttc gtaggttgta aaacggtgtt ggcattcgtc gcactcacgt cttctacgaa
    18061 tggtgttccc ttcttctgct tggcgactat cgataacact tgacttggta gccccacatt
    18121 ttggacaacg catcctttcc ctccttatcg ttttcttttc attataccat tttttaagcg
    18181 attcccaaaa caattcttct ttttgcttga caagtttttt gttttgttgt attatttaat
    18241 taagacaaaa gggtaaaaga aaggagacta agatgtcctg gacatttgac aacaaaaaac
    18301 ccatctattt acagattatg gagaaaatca agcttcagat tgtttcccat acactggaac
    18361 ccaatcaaca acttccaacc gtgagggagc tagctagcga ggctggtgtc aatcccaata
    18421 ccatccaaag agccttatca gaccttgaac gagaaggatt tgtctacagc aagcgaacaa
    18481 ctggacgatt tgtgactaag gataaggagc taatcgctca gtcacgcaaa caattatcag
    18541 aagaagaatt ggaacacttc gtttcctcca tgacccattt tggctatgaa aaagaagaac
    18601 taccaggcgt agtcagtgat tatattaaag gagtttaagc ctatgtcatt actagcattt
    18661 gaaaatgtat ccaaatcata tggagcaaca ccagcccttg aaaatgtttc tcttgacatt
    18721 ccagctggaa aaattgtcgg ccttcttggg ccaaacggct caggaaaaac aaccctgatt
    18781 aaactaatta atggcctctt acaaccagat caaggacgtg tcctcatcaa cgacatggac
    18841 ccaagcccag caaccaaggc cgttgtagct tatttgcctg atacgaccta tctcaatgag
    18901 caaatgaagg tcaaagaagc cctaacctac ttcaagacct tctataaaga tttcaatctt
    18961 gaacgcgccc atcatctact tgcagacctg ggcattgatg aaaatagtcg tctcaagaaa
    19021 ctatcaaaag gaaacaaaga aaaggttcaa ctgattttgg ttatgagccg tgatgctcgt
    19081 ctctatgttt tggatgaacc cattggtggg gtggatccag cagcccgtgc ttatatcctc
    19141 aataccatta tcaacaacta ctcaccaact tctaccgttt tgatttctac ccacttgatt
    19201 tctgatatcg agccaatctt ggatgaaatt gtcttcctaa aagacggaaa agtcgtccgt
    19261 caaggaaatg tagatgatat tcgctacgag tcaggtgaat ccattgacca actcttccgt
    19321 caggaattta aggcctaagc aaaggagatt atttatgttt tggaatttag ttcactacga
    19381 atttaaaaat gttaacaagt ggtatttagc cctctacgca gccgtgctag tcctttctgc
    19441 cctcatcgga atacagacac aaggctttaa aaatctacct taccaagaaa gtcaggctac
    19501 tatgctactt tttctagcta cagtctttgg tggcttgatg cttacacttg cgatttcaac
    19561 cattttcttg attattaaac gcttcaaagg tagtgtctac gaccgacaag gctatctgac
    19621 tttgaccttg ccagtttctg aacaccatat catcacagcc aaactaatcg gtgcctttat
    19681 ctggtcattg attagcaccg ctgtattggc tctaagtgct gttattattc tggctttaac
    19741 agctccagaa tggattcctc tttcttatgt gattacattt gtagaaacac atctccctca
    19801 gatctttctt acaggtatat ccttcctact aaataccatt tcaggaatcc tctgcatcta
    19861 cctggctatt tccattggac agcttttcaa tgaataccgt acagcactcg ctgttgcagc
    19921 ctacattggt atccaaatcg tcattggatt tattgaactt ttcttcaatc ttagttccaa
    19981 tttctatgtc aattcactgg taggactcaa tgaccatttc tatatgggag caggtatagc
    20041 cattgttaaa gaactcatat tcatagctat cttttatctc ggaacctact acatcttgag
    20101 aaataaggtt aatttgcttt aaataatttt tacctagata tgtaacatac tcatagaaca
    20161 aaagagacca ggcaaaaagt ctttaaaatt agaaaacgca tagtatcaag tgttaaaaat
    20221 ccttgatatt atgcgttttt tgtgagctga cttatttcct ttcgctatat cgcaaaatga
    20281 aataagaacg gaacgatggg attttggaat tcaaatcaat ttataagaat gttttagaag
    20341 taatattatc ctattccaga ttcagttcac tatacaattg agttttcaag caacctgttt
    20401 acataatgtg tacataatta ggttcgtgat tccacccttt tcacctttaa aaacctcgct
    20461 ttcgcaaggc tcttctattt ataagataag gcacgtttaa aggttttcca aatccctaaa
    20521 tcatccgttt gaagaacgag actagcatac atgcgtccga taaatcctgt tgctaccacc
    20581 gcaaaaatca ctgtaatagc aagtgaaatc catgcttctg ctccccccgc atagccatta
    20641 atcgttcgaa acggcataaa gaaggtcgaa ataaagggaa tataagaacc aatcttcaag
    20701 aggagattgt caccagctgc acctagagct gtcactccaa aaaaaccacc cataatcaaa
    20761 atcatcaaag gcgacaaggc tttccctgag tcctcaggac gagaaaccat agatcctagg
    20821 aaggctgcca agactacgta catgaaaaga ctgatcaaaa taaagagcaa ggtattcagt
    20881 gagatagcat ctcccaagtg atccaaaata ccagactgag ccaagaatgg caaatcttta
    20941 aagagcaaaa cggcagccag accacctaca acatagatcc caatatgcgt taaaatcact
    21001 agaaacagag ccatcatccg cgcatagaaa tagtgacttg cccttatgct agaaaaaacg
    21061 acttccataa ttttggtgcc tttttcactg gcaacttcct gagctgttac acccgcatag
    21121 gtaatcagaa tcatataaag aaagaatcct aaggcacctg ctgcaattgt ttgaataaac
    21181 tttttatttt ccttggcttc atcaatcttt tctgtgaatt gaattgtctg cgctaagcgt
    21241 ttttcctgct cttgagacaa ggaagcagtt gaacgattaa gctgattttg cagttcattg
    21301 agtgtacctg taacctcaaa tttaattcca ttttcaagcg atgtttcgcc atgataaact
    21361 gcctttagaa cactatcttc ttgatcaatg gtcaaataac cttttaattt ttcttcttta
    21421 attgcttctt tggcacttgc ttcgtcttta tagtcgaagt taacaccatt tacattcttc
    21481 agtccttctg ctacagatgg cactgttgtc actactgcca ctttattatt tttagccata
    21541 gaagaacctt ggatatgccc aattcctaca gagattccta aaaagaggaa cggcgaaatc
    21601 accataaaga agaaactcca tgactcgaca tgtcgaagat aggtttcctt gattacaacc
    21661 cacatatttc tcatacttcc actcctgatt ctagtttaaa gatttcatcg atagttggcg
    21721 cttgttggtc aaatgttgcg atatattgac cttgagtcaa gattgggaag agttcccttc
    21781 cagcgctctc atcctccaaa atcaatttcc aactgccttg tttggtcaag ctcacctgtt
    21841 tgacatgagg aagattttcc aattcttcct tgcttcgttc acttgaaaca aagagacgcg
    21901 ttttcccgta ttgattgcgg acatcctgaa ctggtccgtg caagaccaca cggccatctc
    21961 ggatcatcag aatatcgtca caaagttcct caacattggt catgacatgg tcagaaaaga
    22021 taatggttgc tccgcgctct ttttcctgaa aaatgacttg tttgagcaat tctgtattaa
    22081 ctgggtccaa tccactaaaa ggctcatcca agataatcag gtctggttca tgaatcagag
    22141 taataatgag ctgaatcttc tgctgatttc cttttgacag actcttgatt ttatctgtca
    22201 gctttccttt cacttccaac ctcttcatcc attgagggag tttttctttg acttctttgg
    22261 catccatgcc ttttagagtc gccaagtagc gaacttgttc aagaactgtc aatttaggca
    22321 tgagactgcg ttcttcaggc agataaccaa tccgagcata ggtctcctga cgaatatcct
    22381 gaccatccag accgatttct ccctgatatt ctaggaattt caaaatacta tggaaaatcg
    22441 ttgtttttcc agcaccattt tttccgacta gtcccaaaat acgacctggt cgcgcttgaa
    22501 agtcaatacc aaacaaaact tgcttggagc caaaactttt ctctagactt cttacttcta
    22561 gcatctttca cctccgaaat ttcttgcact cattatactc ctttttgata gcctttacaa
    22621 tgtttttgtc catttttaga agactattgc tgtgtaaaat atggcctgga gcacttttat
    22681 actcaatgaa aagcaaagag cgaactagga agctagccgt aggctgctca aagtacagct
    22741 ttgaggttgc agataaaact gacgaagtca gctcaaaaca ctgttttgag gttgtggata
    22801 gaactgacga agtcagtaac tatatctacg gcaaggcgaa gctaacgtgg tttgaagaga
    22861 ttttcgaaga gtattagtga taaatccatt atacagtagc aaactcaatt tataccttcc
    22921 gctcctcaac tgtctatttt taatcctgaa ttgttatttg agtaactcct ttttcctcat
    22981 aaagttttct tcctctaaaa cttctggaaa aaagcgaata gtttcagaca acatttttat
    23041 aagaaacaag ttcatctgtc atttcaagaa ggagtaatcc tttatctact aatggacgga
    23101 acggaattca accgcttgtc cgatatattt tctaaggatt atatagtaaa atgaaataaa
    23161 aacaggacaa atagatcggg acagtcaaat cgatttctaa caatgtttta gaagtagatg
    23221 tatactattc tagtttcaat ctgctatatc tattatgcac accactatag gatctaataa
    23281 aaatcacaac aagttcattc atagatggtt acctcaggga actaagaaaa cgactacaaa
    23341 ggaagtcgca ttcatcgaaa agtggattaa caactatcct aaaaaatgct tgaactacaa
    23401 gtcccccaga gaagacttct ggatgactaa cttgaacttg aaatttagca ataattaatt
    23461 caccatctaa ctatatttag taattatttc agaactgatt aatattaaaa ttaactaaca
    23521 attcaaagga ttcatactag ccataaatta cgtccatcag agagagactc ttactacttt
    23581 tagattttag tctttctagc ttcagaatac atctaaactt tagggaaaat gactattcga
    23641 aagcgcgaat gcctcaaaat tatctcagat aagctattcg aaacttagaa tgcttttaaa
    23701 tttatggaat tgcgattatt cgaaacctag aatgcatata acctttagtt gacagaccta
    23761 ttctaagtct cgaagggcta tttactttct attccttatc aaaaaagact cattccccct
    23821 ttctcctcca aaatatggta tagtagaaat atactatcta tgaggagttt acatgtcaca
    23881 ggataaacaa atgaaagctg tttctcccct tctgcagcga gttatcaata tctcatcgat
    23941 tgtcggtggg gttgggagtt tgattttctg tatttgggct tatcaggctg ggattttaca
    24001 atccaaggaa accctctctg cctttatcca gcaggcaggc atctggggtc cacctctctt
    24061 tatcttttta cagattttac agactgtcgt ccctatcatt ccaggggcct tgacctcggt
    24121 ggctggggtc tttatctacg ggcacatcat cgggactatc tacaactata tcggcatcgt
    24181 gattggctgt gccattatct tttatctagt gcgcctatac ggagctgcct ttgtccagtc
    24241 tgtcgtcagc aagcgcacct acgacaagta catcggctgg ctagataagg gcaatcgttt
    24301 tgaccgcttc tttattttta tgatgatttg gcccattagc ccagctgact ttctctgtat
    24361 gctggctgcc ctgaccaaga tgagtttcaa gcgctacatg accatcatca ttctgaccaa
    24421 accctttacc ctcgtggttt atacctacgg tttgacctat attattgact ttttctggca
    24481 aatgctttga cacgtaaaaa atccgtttgg tttcccaagt ggatttttaa agcgtagatt
    24541 aactatagct tgatactaaa tatactttgg tatggaaatt atgcatattt ttcgatagtg
    24601 aggcgaggac ttacctagcc tttccgccgt gatagaaaca cctgaaatct aatggtttca
    24661 ggtattcgga aactttgaga cactaggctc aaagtttagg tatggaattt cgaagaaagt
    24721 cgctaccgtc cgtaatcact taaggaaagg ctcaaaaata ttgttttcaa ccacaaaatc
    24781 cgtttggttt cccaagcgga ttttgtgctt tattttgaaa cttcttttgc aagaacaaag
    24841 ttcccaagtg tggcagaacc atttcctgcg actgctggcg tcacgatata gtcacgcaca
    24901 tctggtactg gtaggtaacc attaagaaga gatgtaaatt tctcacggac acggtccagc
    24961 atatgttgtt gagccatgac ccctccacca aagacaatca cgtctgggcg gaaagtcact
    25021 gtcgcattaa ccgcagcttg agcgatatag taggcttgaa catcccaaac agggttgttg
    25081 agttcaatat tttccccacg tacacctgta cgagcttcca aacttggacc agctgcataa
    25141 ccttctagac atcccttatg gaaaggacaa acacccttaa a
//
LOCUS       DBMVGT010000023        24741 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.023, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000023 DBMVGT010000000
VERSION     DBMVGT010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 24741)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 24741)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..24741
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.023"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(427..1059)
                     /locus_tag="AC0DU4_001050"
     CDS             complement(427..1059)
                     /locus_tag="AC0DU4_001050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237025.1"
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLM
                     NMIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIG
                     QKLSRSEQRLRQKQALEQVGLAYLDLDKRIFELSGGESQRVALAKIILKNPPFILADE
                     PTASIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
     gene            complement(1061..1828)
                     /locus_tag="AC0DU4_001051"
     CDS             complement(1061..1828)
                     /locus_tag="AC0DU4_001051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1430 domain-containing protein"
                     /protein_id="HIN4237026.1"
                     /translation="MSQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRISSQD
                     ERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSILFWIDAVQ
                     NYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIAT
                     SILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVE
                     IGVAFLVLLLFTGLSLLQLHVQMQKENKMSILVLKGG"
     gene            complement(1879..3618)
                     /locus_tag="AC0DU4_001052"
     CDS             complement(1879..3618)
                     /locus_tag="AC0DU4_001052"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HIN4237027.1"
                     /translation="MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSES
                     FSESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDI
                     VNSESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGG
                     ESYKLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIIS
                     DIQDRLGHGTAVVAQIVGDDNINGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDG
                     NDIINLSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVIIVAALGNDSLNVSN
                     QSDLLKLISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPA
                     GSTLSLSELGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYK
                     LKDQPYNYMFVKKILEETLPVKNGIKVLNIPNVLRYDLNMLQLEYKNEQSWDSFIDNV
                     NLIELEERIQTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLVGVLLLF
                     ISMVNILWAKKSK"
     gene            complement(3642..5750)
                     /locus_tag="AC0DU4_001053"
     CDS             complement(3642..5750)
                     /locus_tag="AC0DU4_001053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="HIN4237028.1"
                     /translation="MKIPMIYQMENSECGLACCAMILNYFKYEISLNELREIYPSSRS
                     GYSLLSISKVLGDFNISSHAFKASVRDLKPLSFPLICFWESSHFIILEKISKNKFYIL
                     DPAKGRQRMSISEFERHYSNIILTFKKLDSFMSRKDNKKSPVLKYFFKYRNKLGILFF
                     VTALLYVIQSLVPIANRYIIDTNFKDDSYSSRMLFTILFIFTVSFSLMYLLRQIYVAS
                     LKYIMDKEISYDFMKHLIYLPYSFYEKRTLGDILFRANSIVYIREILSNNFIAAILDL
                     LMIVVYAVVLFSFSKYMVIFLISLSLALSIVMYPIIKISKNLIDKNIKEKVNVQNITS
                     EVISKNSDIKLTGEEEFWINKWDNFNTKQLIIGRKLDIHLSIVSSITNVLQIILPVLT
                     LIIGVNIKTFEQLTLGQIVAISTVSPYFISPIISLSDNYIQLMLLKGYFLRIEDVFNT
                     KSELIPERVSQDIKFDKKIELKDIWYKYGLFDDYVLKGINVTIKKGETVAIVGESGSG
                     KSTLAKILLGLLEPNIGSIEVDGVEKEEIGQTLYRKIFGAVLQNSTLSYGTLRENLTF
                     GHFVSDEELMTNLNSIGLSNVVKSLPLGLETIIAEEGNNFSGGQQQMILLARCLLSKP
                     SVVVLDEATSSLDNLSQQITTSYLSEIGTTKILIAHRLDTIKSADKILVMHNGEIVEI
                     GTHRELLELGGIYKQLYSNN"
     gene            complement(5747..6676)
                     /locus_tag="AC0DU4_001054"
     CDS             complement(5747..6676)
                     /locus_tag="AC0DU4_001054"
                     /EC_number="3.4.24.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912951.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M50 family metallopeptidase"
                     /protein_id="HIN4237029.1"
                     /translation="MLKILNNSVIYLCLIPLLFLLLIIFPNDSLIYYFRLILISLISI
                     TLHELGHFLVGRCLSYKLEMLATPFFFYFRKKIYFKFPVLLAFGYCQMSNRNITNEKN
                     SDRNLVFYFFGGGGANLIVAILALLGFVPYASEFFILNIILFLVTVCLPIDGTDGNAI
                     REIVLYSKDSKTYQRFFANSLYNNPYITIDDFAKLTSKEKSFFSKFEKCLINLYFEVK
                     GEGSAFTIANHEVFDSNIQENIIHEYYKLLHKSSDWIIPQNLSLEEVVFTLSNYIYSK
                     NNKYLEKIKYLKKLVDFRQEEIIDFILNKEEVL"
     gene            complement(6657..7361)
                     /locus_tag="AC0DU4_001055"
     CDS             complement(6657..7361)
                     /locus_tag="AC0DU4_001055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009055 - electron transfer activity
                     [Evidence IEA];
                     GO_function: GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin family protein"
                     /protein_id="HIN4237030.1"
                     /translation="MNKIFIYAGVRNHNSKTLEYTKRLSSIISSRNNVDISFRTPFNS
                     ELEISNSDSEELFKKGIDRQSNADDGGVIKKELLESDIIIISSPVYLQNVSVDTKNFI
                     ERIGGWSHLFRLAGKFVVTLDVAESNGSDNVSEYLRDIFSYMGGQILHQVSITNSLKD
                     IAEAQLMEATYKIEDVLEGKIKYKTTDYQERAYQTLKLILENYDSEHFEKMYWEKKRL
                     FEANSLEEWYYVENIK"
     gene            complement(7711..10701)
                     /locus_tag="AC0DU4_001056"
     CDS             complement(7711..10701)
                     /locus_tag="AC0DU4_001056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="HIN4237031.1"
                     /translation="MKYKIKNVHKTLFIKERYQILSERNDNSLNNFSLNNWRSTMSII
                     SEKTFEEMLKLNNYNKKIFSNTVNYDYTEEQIRLYSEYAKNSEWYKFAEGSFEIFRKH
                     PQRINFKKDFSRILEPFIINLLKLINNYLENKEYEWIDKNGNIFSSLVFYLEDLIYPW
                     IVKPLVLEINSLREKGLLEGESEQQRYKYFITLFDKEENILNFYNKYPVLLRQISESC
                     LRFYTYFIEILSNLENDFSVLEEELGLRGKLNDIKFGKGDTHSQGKTVLILFFDDAKI
                     VYKPKNLIINNSLNTIAEYIRKVDEKIRIRIPRTIAYSDHSYEEFIDYLPLEQKKKLP
                     EYYYNFGVLLAFIYLFNGSDIHFENLISYGDMPVIIDFETMLQQPLFDDKTGQSLLDT
                     LFHRVTRTLLLPTEGVKREDGLDVEMSALTGNFKKDAFNGQVLINLNTDKVKFDIGKI
                     DFEGGKNLPVRDGDIEFDKYIKDFKKGFRDFYLIFEELNKTEEFKMLLKANLYGLKTR
                     VLFRDTNSYASVLSFLYHPDFYEEMLDREKALENLWSNKFSNQGIVASECEQMRLLDI
                     PIFYTDTNINEIYDDFGNHFISLHQFSGYDYFMKYLPNNNLENLEKQLDIIEIYFPSF
                     DQRKKGYKLNLSNRKKLPNESLVTILHNEVENIADSLVINNIYDEYPIWSIPVNFKGS
                     KWCLEQTGNDMYRGRAGILLFMYYVKLLKDKSSYTQLYNKMLSAIPPSVSLSKTTFGL
                     TGDIGYFIVLSIIEDYDTNTLACLNYIKSVLTELEKTDFASVSNKSDYINGLLPLINT
                     LVRYYRRGIEKERVLRLVLSLGDTLYNDVSERDNSNFGYSFGHGLSGVIFTLKNIYKV
                     TRLKKYKELILQLVPREKIKIHSLKWCSGEFGTLVNHPQSVPEGIVASLDNDTFCHGS
                     MAIINFYIDYMKEMDTSMELESLLCSVVMNKSKEGEYRIVQTSNFPDFSLYTGVTGIA
                     YTFLRYIALNQNDKKIVIPSLLEI"
     gene            complement(10818..11006)
                     /gene="pneA2"
                     /locus_tag="AC0DU4_001057"
     CDS             complement(10818..11006)
                     /gene="pneA2"
                     /locus_tag="AC0DU4_001057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit PneA2"
                     /protein_id="HIN4237032.1"
                     /translation="MKNDFVIGKSLKELSLEEMQLVYGGTDGADPRSTIICSATLSFI
                     ASYLGSAQTRCGKDNKKK"
     gene            complement(11013..11237)
                     /gene="pneA1"
                     /locus_tag="AC0DU4_001058"
     CDS             complement(11013..11237)
                     /gene="pneA1"
                     /locus_tag="AC0DU4_001058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-peptide bacteriocin subunit PneA1"
                     /protein_id="HIN4237033.1"
                     /translation="MTNFNSNEKFCGKSLKSLSADEMSLIYGASDGAEPRWTPTPIIL
                     KSAAASSKICISAAVSGIGGLVSYNNDCLG"
     gene            complement(11340..11510)
                     /locus_tag="AC0DU4_001059"
     CDS             complement(11340..11510)
                     /locus_tag="AC0DU4_001059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhrA family quorum-sensing system peptide"
                     /protein_id="HIN4237034.1"
                     /translation="MRKKRGIKKLVTFALLGVFMFSNTIPYQQFIQKNKQLEIRVQSQ
                     KKSNGLDVGKAD"
     gene            11703..12566
                     /locus_tag="AC0DU4_001060"
     CDS             11703..12566
                     /locus_tag="AC0DU4_001060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237035.1"
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSA
                     DLLFKLSQRLEVPLDYFFNEQIEIKSNLSNFKQLSARLLDDRNYDDLEYIYRIEIERS
                     TFLTLEDRTYLEWIKAIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFY
                     SLVGREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEA
                     LETIELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEAKELCKIYNNPLMLMK
                     IENYLKELDTV"
     gene            12949..13569
                     /locus_tag="AC0DU4_001061"
     CDS             12949..13569
                     /locus_tag="AC0DU4_001061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237036.1"
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFV
                     SGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQ
                     ELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
                     VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     gene            13655..14098
                     /gene="tsaE"
                     /locus_tag="AC0DU4_001062"
     CDS             13655..14098
                     /gene="tsaE"
                     /locus_tag="AC0DU4_001062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HIN4237037.1"
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILTGELGAGKTTFTKGLA
                     KGLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWG
                     NLLGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            14088..14606
                     /locus_tag="AC0DU4_001063"
     CDS             14088..14606
                     /locus_tag="AC0DU4_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455540.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyltransferase family protein"
                     /protein_id="HIN4237038.1"
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSE
                     EMEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNG
                     LGSLLLEEAIEWAQAGGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGK
                     FIDVYLMGKLIG"
     gene            14614..15630
                     /gene="brpA"
                     /locus_tag="AC0DU4_001064"
     CDS             14614..15630
                     /gene="brpA"
                     /locus_tag="AC0DU4_001064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biofilm formation/cell division transcriptional
                     regulator BrpA"
                     /protein_id="HIN4237039.1"
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGE
                     ETKVIEATEPLTILLMGVDTGNAERTETWVGRSDSMILMTVNPKTKKTTMMSLERDIL
                     TRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVG
                     GITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQ
                     REVIQKVMEKALSLNSVGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQ
                     QLQGEGEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVG
                     DEDN"
     gene            15715..16971
                     /locus_tag="AC0DU4_001065"
     CDS             15715..16971
                     /locus_tag="AC0DU4_001065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HIN4237040.1"
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGD
                     NEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIF
                     FALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
                     VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLR
                     LSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQG
                     KTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRMLDIPAKNLEEHGVVS
                     EFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIG
                     GRSRADVRHIAVMHAFNLVRKALLSD"
     gene            17026..18192
                     /gene="recA"
                     /locus_tag="AC0DU4_001066"
     CDS             17026..18192
                     /gene="recA"
                     /locus_tag="AC0DU4_001066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003697 - single-stranded DNA binding
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HIN4237041.1"
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGE
                     RAEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGI
                     AAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVA
                     ALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGN
                     PETTPGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAV
                     VEIMYGEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFD
                     EIDKQVRSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE"
     gene            18499..19869
                     /locus_tag="AC0DU4_001067"
     CDS             18499..19869
                     /locus_tag="AC0DU4_001067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HIN4237042.1"
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVG
                     RFLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWIL
                     GALLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLR
                     YIGDSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRK
                     SVPELLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQFSVNTFGAVIISAQ
                     TAARRIMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIF
                     LFFASPALVSFLASSTDGYLIENGSLYLQISSAFYPILSLLLIYRNCLQGLGQKILPL
                     VSSFIELIGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAIL
                     ATKVQS"
     gene            20245..21201
                     /gene="lytA"
                     /locus_tag="AC0DU4_001068"
     CDS             20245..21201
                     /gene="lytA"
                     /locus_tag="AC0DU4_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase LytA"
                     /protein_id="HIN4237043.1"
                     /translation="MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWR
                     KDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDY
                     RLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
                     REQFKYDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLAD
                     RWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEG
                     AMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK"
     gene            21579..21740
                     /locus_tag="AC0DU4_001069"
     CDS             21579..21740
                     /locus_tag="AC0DU4_001069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000289348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237044.1"
                     /translation="MYVINVCDVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKG
                     ERNITNGFK"
     gene            21727..21933
                     /locus_tag="AC0DU4_001070"
     CDS             21727..21933
                     /locus_tag="AC0DU4_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000366086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237045.1"
                     /translation="MDLSNKAPNLRKKLGADGESPIDIFKLVQKIENLTLVFYGLGKN
                     ISGVCYKGTQFSLIAVNSDMSLGR"
     gene            21979..22332
                     /locus_tag="AC0DU4_001071"
     CDS             21979..22332
                     /locus_tag="AC0DU4_001071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="HIN4237046.1"
                     /translation="MKKSSVSLILIGEGDETERKADQFASYFLIFPSSLYRMVEEIRE
                     NANRTHLEVEDIIKLGQFYGISHKAMLYRLRNDGYLDAEEIKNMDISVIETASRLGYD
                     TSLYRPLSESKKKCY"
     gene            22466..22891
                     /locus_tag="AC0DU4_001072"
     CDS             22466..22891
                     /locus_tag="AC0DU4_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000204059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237047.1"
                     /translation="MTSRVFIDADCISVFLWVGTEHLLEKLYLGKIVIPQEVYDEINI
                     PTIPHLKSRIDQLVAKGSAEIVSIDIGTEEYALYRDLTRNHDSNKIIGKGEAASISLA
                     KKHNGILGSNNLRDVKSYVKEFSLEYMTTGDILVEAFKA"
     gene            23299..24289
                     /locus_tag="AC0DU4_001073"
                     /pseudo
     CDS             23299..24289
                     /locus_tag="AC0DU4_001073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001101214.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            24279..>24741
                     /locus_tag="AC0DU4_001074"
     CDS             24279..>24741
                     /locus_tag="AC0DU4_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001111259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237048.1"
                     /translation="MPANTKVIFQETFADFQNYYVLIGGTATSIVLDSQGFKSRTTKD
                     YDMVIIDEVKNKEFYTTLNHFLELGEYQGSQKDEKAQLFRFTTTNPEFPSMIELFSIL
                     PEYSLKKDGREIPLHFDQDASLSALLLDEDYYNILVHEKETIQGYSVLSNCG"
BASE COUNT         8091 a         4125 c         4317 g         8208 t
ORIGIN      
        1 tggaacagca gaaagtaaaa ctgacctcat gaggaggaag aaagtggctc atgaggtcag
       61 gggttttgta agttacatct aattgagaga ggtatgaatg atttgggata aagatagttt
      121 tcttttaaaa cggttgtagg aggaaaatct ctcctacact attattgatt ctgagagaaa
      181 attgcaaaat atcatctacc aaactttcaa ttattaagat tttttgcagt ttatctgaat
      241 tagaatcgca aggcttctca ataatataat tgtcgaattt tttcattcta acttcctctc
      301 cattatttct tcctttatca agaaaaagtt acctcaatat taataaagta caattctaaa
      361 ttaactccaa ttcttgattc atgataatat ttcagtaact catcgtgcaa ttaaaaacaa
      421 ggatttttat ttcagatgat ccatcgtgaa cacttcatca gccatctccc aaattgccgg
      481 attatgtgtt gcgataatga ttagcctatt atcatctcga agagatagca aaatctccat
      541 aatcaactga gaggttgctg ggtctattga agctgttggc tcatctgcca gaataaaggg
      601 tggattcttt aagataattt ttgccaaggc aacccgttgc gattctccgc ccgataactc
      661 aaagatgcgc ttatctaggt caagataagc caggccgacc tgttctaaag cctgcttctg
      721 cctcaaccgc tgttccgacc gactcaactt ttgaccaatg agacctagct taaggttttc
      781 ttcaatactt tggttttcaa ttaagccaaa gttctggaag aggtagccca attcgtgacg
      841 gaaaaaatca ctcgatttat aattggccaa gtctttacct cggtaaaaaa tcgtcccatc
      901 ataaggttct aatttcccaa tcatgttcat caaggttgtt tttccgctac cacttgaacc
      961 aattaaggca tagacttttc cagcctcaaa tgtcattgaa agattcgaaa ataactctcg
     1021 ttctccaaaa gatttactca cctgtttaag ttcaatcata ttaacctccc ttcaaaacaa
     1081 gaatggacat cttgttttct ttctgcattt ggacatgtaa ctgtaaaaga gatagaccag
     1141 taaagagtaa caagactaag aaagcaactc ctatctctac ctgaagaaat acactcgcaa
     1201 caaatcccag taaaaacaca cccagttgag caaagagata agtgcgatgg atttctaaga
     1261 acctgagacc tgcaatgcgt ttgataaaaa tggcacgtct aaattcttca aagtagagcc
     1321 tattcatagt gttaaacaac aagattgaag ttgcaatccc aagcacagct cctgctagca
     1381 ttacccaacg ttccctctgg atattatcca ataatgtgat gtagttgtgg taacctgttt
     1441 gcatttctga gacccaattt tcaatgcctt gtctctggat aagctcctgg gcatcagaca
     1501 attgattaaa gagaacgtag ttctgtactg cgtctatcca aaacaaaatg gactgtggac
     1561 cagttgattg gggtgttata acaatgatga ttggatcttt caaaaactgc tggtaagaaa
     1621 taggggtcgt attatacaca aaacgatcct gacctgattc taaataacct accgtagcag
     1681 tcatttgctg tcgttcatct tgactagata tgcgactggt taagtcgtct tcaaaaacag
     1741 atttataatg ttcttcctct gaacggaggt gttcaggcag caataagaca aactccccta
     1801 catcaaggtg attcatcttt tgactcattt tagttgaact gtaggactta ctttttcaga
     1861 gggctccaaa ttttattttc atttactttt tttagcccat aaaatattta ccatacttat
     1921 aaaaagtagt aatactccaa ctaaactgac ttgtaatgaa ttatatgtat tttctgaagt
     1981 gttaggtaaa taattttgag agtacccttc tcgggcaata gtaataatat tgtgtgtgtt
     2041 tatttgttta attccaatag tagtttgaat tctctcttcc aactcaatta aattaacatt
     2101 atctatgaaa ctatcccaac tttgttcatt tttatattct aattgtaaca tattcaaatc
     2161 atatctcaat acgtttggta tatttaacac ttttatacca ttttttactg gtaatgtttc
     2221 ttccagaatt ttttttacaa acatataatt atagggctga tcttttaatt tgtatttatc
     2281 aataatcatt gcaatcgcac cagaaacttt aggagcagca aatgagtttc cataaagata
     2341 cgtatatcct cctagtgttg ccgaaaaaat ccaatcttct ttatattttt ctgcattaat
     2401 aaagttatta agtcctaatt ctgaaagaga taatgttgag cctgcaggcg catatattgc
     2461 atcagaatcc cctttattgc taaaatctga taaattacct aagcgatcta tgcctccgac
     2521 cgaaattgta gatgagaaat aacttggaac atcaactact aatcctggtt ttcttacttt
     2581 tttgcgtgaa ctaataagtt tcaataaatc tgactgattt gatacattta gggagtcatt
     2641 ccctaatgca gctactataa ttactccttt ttgattcgcg taatcaatag cctttttata
     2701 cttcaaaaat gtttcaaaat catttgttcc gtcctcatat tctccatcaa tcattaaata
     2761 ttgtccagta ctaagattga taatatcatt gccatcatct acagcatcaa aaattgcttt
     2821 tacaatccaa tctggactag ctgacgactt accaaatatt ctatagacgt taatattaac
     2881 gtgaggattt actccattaa tattgtcatc ccctacaatt tgagctacaa cagccgtacc
     2941 atgacctaat ctatcttgaa tatctgatat tattccttcc tctccctcct cttttcctaa
     3001 atatccttta ttggggacat agttttttga gtgatttgaa agatttttca gtaatccagt
     3061 attttgtaaa tcgactcctg aatctaaaat agcaattgaa actttagaat tacttttaga
     3121 atataattta taactttcgc ctccaccagt aactttatct atatcccatt catattttct
     3181 tacaatcgac gattctaagt tatctttgtc atgctctata tttcctcctc tattatctag
     3241 atgagaaaca ttttccttaa ttttattatc taaattatct tcgcctagta aattattact
     3301 ttcagagtta acaatatcgt tatttatttg tggttcaagt tccaatttac aacagttttt
     3361 ttctaaatgt ttatctgttg ttacaaataa ttctgtctta tcgatttgaa tacgaaattt
     3421 attttggtct acttcttctt gatttttatt agaatagtca acctgttttt catcagattc
     3481 agaaaaactt tcgctagtct gagtgtgagt tatattgcca tcaagatttt taggtatttc
     3541 ttgagcagta acagaattat tgaacaaaca aaagaataat atcgctaaag tccaatattt
     3601 ttttttcata atcttcataa atttaccctt ttaatcaaaa actaattatt tgaatacaat
     3661 tgcttataaa tgcctcctag ttcaagaagt tctctatggg tcccaatctc tacaatttca
     3721 ccattatgca ttactaagat cttatctgca gacttgatag tatctagtcg atgggcaatt
     3781 aaaatcttag tggtaccgat ttcacttaag taagaagttg taatttgttg agataaatta
     3841 tctaaactac ttgttgcttc gtccaaaaca actaccgaag gtttcgacaa aagacaacga
     3901 gctaaaagta tcatttgctg ctgccctcca gaaaagttat taccttcttc agcgatgatt
     3961 gtctctaatc caagaggtaa agatttaact acattgctaa gaccaattga atttagattt
     4021 gtcattaatt cttcatctga aacaaagtgt ccaaatgtca aattctctct taaggtacca
     4081 taacttaggg ttgaattttg taacactgct ccaaaaatct ttctatacaa tgtttgacca
     4141 atttcttctt tttctactcc atcaacttct attgaaccaa tattaggttc taataaacct
     4201 aataaaattt tagctaatgt actcttacct gaacctgatt ctccaacaat agcaacagtt
     4261 tctccttttt taatagtaac atttattcct ttcaaaacat aatcatcaaa taatccatat
     4321 ttataccaaa tatcttttaa ttctattttt ttatcaaatt ttatatcttg actgactctt
     4381 tctggaatta attcggattt agtattaaac acatcctcta ttcttaaaaa atatcccttt
     4441 aataacatta attgtatata gttatcactt aaagaaatta taggagaaat aaagtatggt
     4501 gagactgtac ttattgctac aatttgtcct aacgtcaatt gttcgaatgt ttttatattt
     4561 acacctataa taagggtcaa aacagggaga ataatttgta aaacattcgt tatactacta
     4621 acaattgata aatgtatatc aagttttcga cctatgatga gctgttttgt attaaaatta
     4681 tcccatttgt taatccaaaa ttcctcttct ccagttagct taatatcact atttttagaa
     4741 attacttcgg aagtaatatt ttgaacatta accttttctt ttatattttt atcaattaaa
     4801 ttttttgaga tttttatgat tggatacatt acaatagata gagctagact tagtgatatt
     4861 aaaaagatta ccatgtactt agaaaagcta aataaaacca cagcataaac cacaatcatt
     4921 aacaaatcaa gtatagctgc tataaaatta tttgatagta tttctcttat ataaacaata
     4981 gagttagctc taaaaagtat atcccctaaa gtacgttttt cataaaaact gtaaggtaaa
     5041 tatatcaaat gtttcataaa atcatagcta atctctttat ccattatata ttttaaggat
     5101 gcaacatata tctgtcttaa taaatacatt agtgagaatg aaacagtaaa tataaataat
     5161 atagtaaata acattctaga cgaatacgaa tcgtccttga aattcgtgtc aattatgtat
     5221 ctattagcta taggtactaa tgattgtatt acatacaata atgctgttac aaaaaataaa
     5281 atccctagct tattcctata cttaaaaaaa tactttaaaa caggcgactt cttattatct
     5341 ttacgagaca taaagctatc taacttttta aatgttaaaa tgatatttga ataatgcctt
     5401 tcaaattcac ttattgacat tctctgcctg ccttttgcag gatctaaaat ataaaacttg
     5461 tttttactaa ttttttcaag aataataaaa tgagaactct cccagaagca aatgagtggg
     5521 aaactgagcg gttttaaatc tcttaccgaa gctttaaaag catgagaact tatattaaaa
     5581 tctcctaaaa ctttacttat agataggaga gaatatccag atctggatga tgggtagatt
     5641 tcacgtagtt catttaaaga aatctcatat ttaaaatagt tcaatatcat ggcacagcat
     5701 gctaatccac attctgaatt ttccatttga tatatcattg gaattttcac aatacttcct
     5761 ccttgttcaa aataaagtcg ataatttctt cttgtctaaa atctactaat ttctttagat
     5821 acttaatctt ttctaaatat ttattatttt tcgagtaaat atagtttgac aaggtaaaaa
     5881 caacttcttc taaagataag ttctgtggaa taatccaatc agaagattta tgtagtaatt
     5941 tatagtactc atggataata ttttcctgaa tatttgaatc aaaaacttca tgattagcaa
     6001 ttgtaaatgc tgacccttca cctttcactt caaagtaaag gtttatcaaa catttttcaa
     6061 attttgaaaa aaaagatttt tctttagagg ttaattttgc aaaatcgtcg attgttatat
     6121 aaggattatt atagagactg ttcgcaaaga atctctgata tgtttttgaa tcttttgaat
     6181 acaaaactat ctctctaata gcattgccat ctgttccatc aattggtaaa cataccgtaa
     6241 ctagaaaaag aattatattc aaaataaaaa attctgatgc gtacggcaca aatcccaaaa
     6301 gtgctaatat tgcgacaatt aggttagctc cacctccccc aaagaagtag aacaccaaat
     6361 tcctatcact atttttttca ttagtaatgt ttctattact catttgacaa taaccgaatg
     6421 ctaataacac tggaaatttg aaatatattt tttttctgaa atagaagaaa aagggagtag
     6481 caagcatctc tagtttataa gataaacatc ttcccactaa aaaatgacct agttcatgta
     6541 atgtaattga tattaacgaa attaaaatca atcgaaaata atagattaat gaatcatttg
     6601 gaaaaattat caataatagg aacaataacg gaatcaaaca taaatatatg acagagttat
     6661 ttaatatttt caacataata ccattcctct aaactattag cttcaaaaag gcgttttttc
     6721 tcccaataca tcttctcaaa atgttcggaa tcataatttt ctaaaattaa ttttaatgtc
     6781 tggtaagctc tttcttgata atccgttgtt ttgtacttaa ttttcccttc aagtacatct
     6841 tcaattttat aagttgcctc catcaactga gcctctgcaa tatctttgag tgaattggta
     6901 attgaaactt ggtgtaatat ctgtcctccc atatatgaaa atatatctct aagatattct
     6961 gacacattat cagagccgtt actctcagca acatctaatg ttacaacaaa ctttccagct
     7021 aatcgaaaaa gatggctcca ccccccaatc ctttcaataa agttttttgt gtccacagat
     7081 acgttttgta aatatacagg agaagagata attataatat cagactctaa taactctttt
     7141 tttataacac ctccatcatc agcattactt tgcctatcaa ttcctttctt aaacaactct
     7201 tctgaatcag aattagatat ttctagctct gaattgaaag gtgtcctgaa agatatatca
     7261 acattatttc tactagaaat gatacttgaa agtctcttag tatactctaa agtcttagag
     7321 ttatgatttc gcactcctgc atatataaat attttattca ttttaattca tcctctcaat
     7381 ttgaatttag tagatttttc aagatagtat ggtacaaaaa cagacttttg ttgactcaca
     7441 ttattacata tgttttgtat taaaccaaaa tcaatactat ttttggagta attttgattt
     7501 tagtttaaaa tcatttctat aacagtagca tatacctcaa gccgtttagc aattagaata
     7561 gaacctttct ttattatatt attatctcaa cgaaaagcta cactattaaa aatattttat
     7621 agaattacat attaaactag tcaatcttgg tatttttata ttgcttaatg agtggacacc
     7681 tctattttag aaacaaaact ataaattaag ctagatttca agtaatgagg ggataactat
     7741 ctttttgtca ttctgattca gtgcgatata ccttaaaaaa gtataagcaa taccagtcac
     7801 acctgtatac aaagaaaaat ctgggaaatt gcttgtttgg acgatacgat actctccttc
     7861 ttttgattta ttcattacaa cactacacaa taaagactcc aattccatac tagtatccat
     7921 ttctttcatg tagtcgatgt aaaaatttat tatggccata cttccatggc aaaatgtatc
     7981 attatctaaa ctagctacaa ttccctctgg aacactttgg ggatgattaa ctaatgtccc
     8041 aaattctcca ctacaccact tcaaagaatg aattttgatt ttctccctag gaactagttg
     8101 taaaattaat tctttatatt ttttaagtct tgtcacttta taaatatttt ttaatgtaaa
     8161 aattacacct gatagtccat ggccaaaact atatccaaaa ttactattat ctctctcgct
     8221 tacatcatta tatagcgtat cacctaaact taatactagc cttagaacac gttccttctc
     8281 tattcctctc ctataatatc ttaccagtgt attaattaaa ggtagaagac cattaatata
     8341 gtcagacttg tttgaaacac ttgcaaaatc agtcttttca agctcagtta aaacactctt
     8401 tatataattt aagcatgcga gagtatttgt atcgtaatcc tctataatgg atagaacaat
     8461 gaaatatcct atatccccag ttaaaccaaa tgtggtctta gataaagaaa cagatggcgg
     8521 aattgcagat aacattttat tgtacagttg agtatatgat gatttatctt tcaataattt
     8581 tacatagtac ataaacagta atattccagc tctaccccta tacatatcat tacccgtttg
     8641 ttcaagacac catttagaac ctttaaaatt aacaggtata ctccaaattg gatattcgtc
     8701 ataaatatta ttaataacca aagagtctgc aatattttct acttcattat gcagaatagt
     8761 aactaaactt tcatttggga gtttttttct attagataag tttaatttat atcctttttt
     8821 tcgctgatca aagcttggaa aataaatttc aatgatatca agttgctttt ctaaattttc
     8881 caaattatta ttaggtaaat atttcataaa atagtcatat ccagaaaatt gatgtaggga
     8941 aataaaatga tttccaaaat catcgtagat ttcattgata tttgtatctg tataaaaaat
     9001 cggaatatct aataacctca tttgttcaca ttcgcttgct acaatacctt gattagaaaa
     9061 cttattgctc cagagatttt ccaatgcttt ttctctatct aacatttctt cataaaaatc
     9121 aggatgatat aaaaaagata gtactgaagc atagctattt gtgtctctaa aaagtaccct
     9181 tgtctttaaa ccatacaagt ttgcttttaa tagcatttta aattcttctg ttttatttaa
     9241 ctcttcaaat atcagataaa aatccctaaa accttttttg aaatctttta tatacttatc
     9301 aaattctata tcaccatccc gaacaggcag gtttttccca ccttcaaaat caattttccc
     9361 aatatcaaac tttaccttat cagtatttaa attaattaaa acttgaccat taaaagcatc
     9421 cttcttaaaa tttcctgtaa gagcactcat ctcaacatca agaccatcct ccctttttac
     9481 tccctctgtt ggaagaagca aagttcgagt caccctgtga aacagggtat ccagcaaact
     9541 ctgaccagtt ttatcatcaa atagaggttg ctgtaacatt gtttcaaagt ctattattac
     9601 aggcatatct ccataggaaa ttaaattttc aaaatgtata tcactcccat taaataaata
     9661 tataaatgct aaaagcacac caaaattata ataatattca ggtaattttt tcttttgctc
     9721 tagaggtaga taatcaataa attcttcata gctgtgatcc gaataagcaa tagttcgagg
     9781 tattcttatc ctaatttttt catcaacctt tcggatatac tcagcaatag tatttagtga
     9841 gttattgatt attaaatttt taggcttgta aacaattttc gcgtcatcaa agaagagtat
     9901 caaaacagtt tttccttggc tgtgtgtatc accctttcca aattttatat catttaattt
     9961 cccccttagc cctaattctt cttctagcac actaaaatca ttttctaaat ttgataaaat
    10021 ttctataaaa taagtataga accgaagaca agactccgat atttgcctca gtaaaacggg
    10081 atatttgtta taaaaattta atatattctc ttccttgtca aacaatgtta taaaatattt
    10141 gtaccgttgc tgctccgatt ccccttcaag taaacctttt tcacgcaatg aatttatctc
    10201 taaaaccaaa ggtttaacaa tccaaggata gattaaatct tctaaataaa atactagaga
    10261 ggaaaaaata tttccattct tgtcaatcca ctcgtattct ttattctcta gataattatt
    10321 gattaattta agcaaattaa taataaaggg ttccaaaatt ctagaaaaat ctttcttaaa
    10381 attaattctt tggggatgtt ttctaaatat ttcaaatgaa ccctccgcaa atttatacca
    10441 ttccgaattt ttggcatatt ctgaatatag tcttatctgt tcctcggtat aatcatagtt
    10501 cacagtgtta gaaaatattt ttttattgta attatttaat ttcaacattt cttcaaaagt
    10561 tttttcagaa ataattgaca ttgtagaacg ccaattattt aatgaaaagt tatttaagga
    10621 attatcattt cgttcagata atatttgata tctttcctta ataaacaatg ttttatgcac
    10681 atttttaatt ttatatttca tttacttacc tcaaacctat acgacttact attgttttaa
    10741 aaaaaaaaac tctctcaaaa ttattagtta cgagagagga aaataaagag caacttttat
    10801 ttttaaaatt gaatatttta ttttttcttg ttgtctttgc cacaacgagt ctgagctgac
    10861 cccaaatatg atgcaataaa acttaatgta gcagaacata taattgttga tctagggtca
    10921 gcaccatctg tgccaccata aaccaattgc atttcttcaa gagataattc tttcaaactc
    10981 tttccgatta caaaatcatt tttcatttta atttacccca aacaatcatt attgtagcta
    11041 actagccccc caataccaga aacagctgca ctaatgcata ttttcgagct agctgcagct
    11101 gatttcaaaa taataggagt aggcgtccaa cgtggctctg caccatcaga tgcaccataa
    11161 attaaactca tttcatcagc agacaatgat tttaaacttt ttccacaaaa tttttcgttt
    11221 gaattaaagt tggtcataag taataactcc tccttataaa aagttaaata agttgctcta
    11281 tatttttcgt tttttcagat aaattataat tctctcattc tcgtgcaaaa tatcgggttt
    11341 taatccgcct tcccaacatc aagaccattg gacttctttt gcgattgcac tcgaatctcc
    11401 aattgtttat tcttctgaat aaactgttgg taaggaattg tattactaaa cataaaaaca
    11461 cctagcaatg caaatgtaac taatttttta attccacgtt tttttctcat gcaatgaaac
    11521 ccctttcttt ttccttgttt ttattctaac agatatattt tatttagtca agtattttta
    11581 tgtaattttt aacttttttt ttttgtttat taccataaag aattatttat tcctttaact
    11641 tgctattttg aactaaaaac tttataatga aattaagcaa ataggaaggt ttattatctt
    11701 taatgaatac actcgcagag aaattcagat tgaaaagaaa agagttgaga ctctcccaac
    11761 aaactcttgc agaaggaatt tgtgaacaaa gtcagattag taaaattgag agagggcatt
    11821 tcattccctc cgcagacctt ttgttcaaac tctctcaacg acttgaagta ccattagatt
    11881 atttttttaa tgaacaaatt gaaattaaat ctaacctctc taatttcaag caattgtctg
    11941 ctcgactatt agacgataga aattatgacg atttggaata tatttataga atagagattg
    12001 aacgaagtac ttttctaaca ctagaagacc gaacttatct tgaatggatt aaagctatta
    12061 ttgactttta tcaatatgac agtaagtgtg aagcaatttc ttcattggaa aatatattat
    12121 taaaagtctc ctcaaatact ctgatttatt taaaggcgtt gaatactcta tctaatttct
    12181 attccttagt gggtcgtgaa caagaatatg aggcaaacta ctctcattta atagagttgt
    12241 atcagacaaa aaatttggac catcaagagt ttttatttgg ctacatcaga gttcgttaca
    12301 actacgctca ctacctagta tcaaaggaaa aatataatga agccatccaa gaagctcttg
    12361 agacgattga actctgtaaa caaagacaga caagctacca actggctcct ctacttattc
    12421 ttgtaggaaa tgctggagcc aaatttctag acagagaaca agtcaaaaat tattatatag
    12481 aagcaaaaga gttatgtaag atttataaca atcctttaat gctgatgaag atagaaaatt
    12541 atttgaagga attagatact gtttagttaa tcttgacatt atagtttttc tgaaacgtta
    12601 aataacctgt aaggctgata gtgaaatgaa tactatcagc cttatgatta tgtgactatt
    12661 agttcgtctc gctccgttag gtgcgagaca aaaaaaacac ccgctagacg gattttcatg
    12721 atttcaaatt tatattcttc gaaaatctct tcaaatcacg tcagctctat ctgcaatctc
    12781 aaaacagtgt tttgagcaac ctgtggctag ctacctagtt tgatctttga ttttcattga
    12841 gtattagtct ctagtgtttg tttagcgtct taaagagaca tttgagaaga ttagaaacag
    12901 ttctctcttt tctcctagta taatgattgg taggaaggga gagagaagat gaaatcaatg
    12961 agaatcttat ttttgttagc tttaattcaa atcagtttga gtagctgttt cctatggaag
    13021 gaatgcatct tgtcctttaa acaaagtaca gcttttttca tcggaagcat ggttttcgtt
    13081 tcaggaatct gtgctggagt aaattatctt tatacccgta agcaagaagt ccatagtgtc
    13141 ctagccagta agaagtcggt gaagcttttt tacagtatgt tactcttaat taatttgtta
    13201 ggagctgttc ttgttttgtc agataacttg ttcatcaaaa atacgctgca gcaagaatta
    13261 gttgactttt tattgccatc cttctttttc ctatttgggc tagatttgct gattttttta
    13321 cccttgaaaa aatacgtgcg cgattttctt gctatgctag acagaaaaaa gacagtgttg
    13381 gtgactattt tagcaacact tcttttctta agaaatccaa tgaccattgt ctcacttctg
    13441 atttatattg gactgggctt gttttttgca gcctatcttg tcccaaattc ggttaagaag
    13501 gaagtttcct tttatggtca tattttccga gatcttgtat tggtcattgt tacgctcatt
    13561 ttcttttaga gaaagcctgt tttttatgga tgttatgatg ataagtttag taggaaaata
    13621 gacacaaaag aaaagttttt ggtataataa gagtatgtac acaaaaaatg aagaagagtt
    13681 gcaagcctta ggggagcgtt tgggccatct attagcaaag aatgatgttt taatcttaac
    13741 tggagaactg ggtgcaggta aaacgacctt tactaaagga cttgcaaaag gattacagat
    13801 ttctcaaatg attaaaagtc ccacctatac tatcgtgaga gagtatgaag gtcgacttcc
    13861 actttatcac ctagatgttt atcgtattga aggagatgct gattctatcg acttggatga
    13921 gtttatcttt ggtggcggcg tgactgttat tgagtgggga aatctcttag gagatgcctt
    13981 gccagatgct tatttagaat tggaaattct aaaagaagca gatggacgcc gtttaaattt
    14041 tcaggcaaag ggtttgcgtg ctgagaaatt gttagaggag cttcaatatg gagtatgaat
    14101 tgctcattag ggaagcagag cccaaagatg cagctgaatt agtggccttt ttaaatcgtg
    14161 tgagtttgga gacagacttt accagcctag acggagatgg tattctcttg actagtgagg
    14221 agatggaaat attcctcaac aagcaagcta gttcggacaa tcagataacc ttacttgcat
    14281 tcttaaatgg caaaattgct ggtattgtaa atattacagc tgatcagcgt aagagagtcc
    14341 gtcatattgg agatctcttc attgtgattg gaaaaagata ttggaataat ggcttgggaa
    14401 gtttgttgct agaagaagcg atagagtggg cacaagcagg tggcattctg cgtcgtctcc
    14461 aactgactgt ccaaactcgt aatcaagcag cagtccatct ttatcaaaag catggctttg
    14521 tcattgaagg tagccaagag cgtggggcat atatagaaga agggaaattt atcgatgttt
    14581 acttgatggg taaactgata ggttagtaga aatatggtta aaaaaattat tggaatggtg
    14641 ctagctttac tttctgtaac tgtagtagga gtaggtgttt ttgcttatac tatttatcaa
    14701 caagggacag aaaccttagc taaaacctat aaaaaaatcg gcgaagaaac caaggttatt
    14761 gaagcgactg aacctctaac cattctgtta atgggagtgg acaccggaaa tgctgaacga
    14821 actgaaactt gggtcggtag aagtgatagc atgatcttga tgacagtgaa tcctaaaacg
    14881 aaaaaaacaa caatgatgag tttagagcgg gatattctga cgcgcattga atcagggaat
    14941 ggtcaggctc atgaagcgaa actgaactca gcatatgcag atggtggagc agagcttgct
    15001 atagaaacca ttcaaaaaat gatgaatatc catattgatc gctatgtaat ggtcaatatg
    15061 agagggttgc aaaaactagt ggatgcagta ggaggtatta cagtcaataa tatcctaggt
    15121 ttcccaattt ctatcagtga ccaagaagaa tttaatacta tttctatcgg tgttggggag
    15181 caacatattg ggggagaaga agccctagtc tatgcacgaa tgcgttacca agatcctgag
    15241 ggggattatg gtcgtcaaaa acgtcaacgt gaagttattc aaaaagtcat ggaaaaagct
    15301 ctcagtttaa atagcgttgg tcattatcaa gagattctaa aagctttgag tgacaatatg
    15361 cagaccaata ttgatttgtc tgcaaaaagt atccctaact tgctaggcta taaagattca
    15421 tttaaaacca ttgaaactca gcagttgcag ggtgaaggag agatacttca aggtgtttct
    15481 taccagattg tttcgagagc acatatgttg gaaatgcaaa atatactccg acgttctttg
    15541 ggacaagaag aagttactca gcttgaaacc aatgcggttt tatttgaaga tttatttggc
    15601 agagcacctg ttggtgatga agataattaa cttttgatac aaataaaaaa atcaatcgta
    15661 ggaaaattcc tgcgattttt tcaaaaaaat acgaatagat aggtaggagg aaacatgaaa
    15721 gcagaaatca ttgctgttgg aacagagatt ttgacaggac agattgtcaa caccaatgcc
    15781 cagtttttgt cggaaaaact agctgagatt ggggtagatg tatattttca gacggctgta
    15841 ggagacaatg aagttcgtct cttgtctttg cttgagattg ccagtcaacg tagcagtctg
    15901 gtgattttga caggcggttt ggggccaact gaggacgacc taaccaaaca aaccctagct
    15961 aaatttttag ggaaagcatt agtctttgat cctcaggctc aggagaagtt ggatatcttt
    16021 tttgccctgc gaccagacta tgcccgaaca ccgaataacg aaagacaagc tcaaattgta
    16081 gaaggagcga ttccactgcc aaacgaaaca ggactggctg ttggaggaaa attagaagta
    16141 gacggagtga cctatgtcgt ccttccaggt ccgccaagtg aattgaaacc catggtctta
    16201 aaccaacttc tacccaagtt gatgacaggg agcaagctgt attcccgagt tcttcgtttc
    16261 tttgggattg gcgagagcca gttggttacg attttggctg atttaattga taatcagatc
    16321 gatcctacct tggcccctta tgccaagaca ggagaagtca ctctacgtct gtcaacaaag
    16381 gctagcagtc aagaagaggc gaatcaagcg ctggatatct tggaaaatca aatcttggac
    16441 tgccagactt tcgaaggaat ttctttacga gacttttgct atggttatgg ggaagaaact
    16501 agtttagcca gcattgtggt agaagaactg aaaaggcaag ggaaaaccat cgcggctgca
    16561 gagagtttga cggcaggtct tttccaagct accgtggcga atttttctgg agtttcaagt
    16621 atatttaagg gtggttttgt gacctatagc ttggaggaaa aatcaaggat gttggatatt
    16681 cctgccaaga atttggaaga acatggtgtg gtgtctgaat ttacagctca gaagatggct
    16741 gagcaggcac gaagcaagac ccagtctgat tttggaatta gtttgaccgg agtggcagga
    16801 ccagatagcc tagaaggaca tccagttggg acagtcttca taggcttggc gcaagagcaa
    16861 ggaactgagg ttatcaaggt taatattgga ggcagaagcc gagcagatgt acgtcatatt
    16921 gcggttatgc atgcctttaa cctagttcgc aaggctttat taagtgacta acttttgata
    16981 taatagtaga taggtctgag gatcattaga atgtaggaga atagaatggc gaaaaaacca
    17041 aaaaaattag aagaaatttc aaaaaaattt ggggcagaac gtgaaaaggc cttgaatgac
    17101 gctcttaaat tgattgagaa agactttggt aaaggatcaa tcatgcgttt gggtgaacgt
    17161 gcggagcaaa aggtgcaagt gatgagctca ggttctttag ctcttgacat tgcccttggc
    17221 tcaggtggtt atcctaaggg acgtatcatc gaaatctatg gcccagagtc atctggtaag
    17281 acaacggttg cccttcatgc agttgcacaa gcgcaaaaag aaggtgggat tgctgccttt
    17341 atcgatgcgg aacatgccct tgatccagct tatgctgcgg cccttggtgt caatattgac
    17401 gaattgctct tgtctcaacc agactcagga gagcaaggtc ttgagattgc gggaaaattg
    17461 attgactcag gtgcagttga tcttgtcgta gtcgactcag ttgctgccct tgttcctcgt
    17521 gcggaaattg atggagatat cggagatagc catgttggtt tgcaggctcg tatgatgagc
    17581 caggccatgc gtaaacttgg cgcctctatc aataaaacca aaacaattgc catttttatc
    17641 aaccaattgc gtgaaaaagt tggagtgatg tttggaaatc cagaaacaac accgggcgga
    17701 cgtgctttga aattctatgc ttcagtccgc ttggatgttc gtggtaatac acaaattaag
    17761 ggaactggtg accaaaaaga aaccaatgtc ggtaaagaaa ctaagattaa ggttgtaaaa
    17821 aataaggtag ctccaccgtt taaggaagcc gtagttgaaa ttatgtacgg agaaggaatt
    17881 tctaagactg gtgagctttt gaagattgca agcgatttgg atattatcaa aaaagcaggg
    17941 gcttggtatt cttacaaaga tgaaaaaatt gggcaaggtt ctgagaatgc taagaaatac
    18001 ttggcagagc acccagaaat ctttgatgaa attgataagc aagtccgttc taaatttggc
    18061 ttgattgatg gagaagaagt ttcagaacaa gatactgaaa acaaaaaaga tgagccaaag
    18121 aaagaagaag cagtgaatga agaagttccg cttgacttag gcgatgaact tgaaatcgaa
    18181 attgaagaat aagctgttaa agcagtggag aaatccgcta ctttttcgat ttttgattca
    18241 agtttttaga ttatatatag tagattgaaa taagatatga acaactttat taggaaagtc
    18301 aaattaattt ctagaaatgt tttagcagct acagcgtact attccaaact caaccaacta
    18361 taatagatcg aaactagaat agtacacatc tacttctaaa acattgttaa aaatcgattt
    18421 gactgtcctt atttcattcc gctatatata agtttgctgt ttcttgtcgc tcctctggaa
    18481 agctgatata atagctttat gaataaaaaa cgaacagtgg acctgataca tggtccgatt
    18541 cttccctcgc tcttaagctt cacctttcca atcttgttat caaatatttt tcaacagctc
    18601 tataacactg ctgatgtctt gattgttgga cgatttcttg gtcaagaatc cttggctgca
    18661 gtaggagcga cgacagcgat ttttgatctg attgtaggtt ttacacttgg tgttggcaat
    18721 ggcatgggga ttgtcattgc tcgttattat ggggctcgga atttcactaa aatcaaggaa
    18781 gcagtagcag ccacctggat tttaggtgct cttttgagca ttctagttat gttgctgggc
    18841 tttcttggct tgtatcctct cttgcaatac ttagatactc ctgcagaaat tcttcctcaa
    18901 tcttatcaat atatttctat gattgtgacc tgtgtaggtg tcagctttgc ttataatctt
    18961 tttgcaggct tgttgcggta tattggtgac agtctagcag ccctgggatt tctgattttc
    19021 tctgccttgg ttaatgtggt tctggatctc tattttatta cgcaattgca tctgggagtt
    19081 caatccgcag gacttgctac cattatttcg caaggtttat cagcggttct ctgcttttat
    19141 tatattcgta aaagtgtgcc agaactcttg ccacagttta aacatttcaa atgggacaaa
    19201 agcttgtacg cggatctctt ggagcaaggt ttggctatgg gcttgatgag ttcaattgta
    19261 tctatcggca gtgtgatttt acagttttct gttaatacat ttggtgcagt gattattagt
    19321 gcccagacgg cagctcgacg cattatgacc tttgcccttc ttcctatgac cgctatttct
    19381 gcatcaatga cgacctttgc ttctcagaat ctaggagcta agcgacctga ccgcattgtt
    19441 caaggtcttc gaatcggcag tcgtttaagt atatcctggg cagtttttgt ttgtattttc
    19501 ctcttttttg ccagtccagc cttggtttcc ttcttggcta gttcgacaga tggttacttg
    19561 atagaaaatg gaagtctcta tctgcaaatc agttcagcct tttatcccat tttgagcctc
    19621 ttgttgattt atcgcaattg cttgcagggc ttggggcaga agatccttcc tctagtttct
    19681 agctttattg aactaatcgg aaaaatcgtt tttgtggttt tgattattcc ttgggcagga
    19741 tataagggtg ttatcctttg tgaacctctt atctgggttg ccatgacagt tcaactgtac
    19801 ttctcactat tccgtcatcc cttgataaaa gaaggaaagg caattttggc aaccaaagtg
    19861 caatcctagt tggatttact gaataaaatc catttcctct agtgaacatc gaaaaaactt
    19921 gtgttctctt cttcagtttg gtgttgaaaa tagtttaaca gacttttgac ttcttttata
    19981 tgatataata aagtatagta tttatgaaaa ggacatatag agactgtaaa aatatacttt
    20041 tgaaaagctt tttagtctgg ggtgttattg tagatagaat gcagaccttg tcagtcctat
    20101 ttacagtgtc aaaatagtgc gttttgaggt tctatctaca agcctaatcg tgactaagat
    20161 tgtcttcttt gtaaggtaga aataaaggag tttctggttc tggattgtaa aaaatgagtt
    20221 gttttaattg ataaggagta gaatatggaa attaatgtga gtaaattaag aacagatttg
    20281 cctcaagtcg gcgtgcaacc atataggcaa gtacacgcac actcaactgg gaatccgcat
    20341 tcaaccgtac agaatgaagc ggattatcac tggcggaaag acccagaatt aggttttttc
    20401 tcgcacattg ttgggaacgg ttgcatcatg caggtaggac ctgttgataa tggtgcctgg
    20461 gacgttgggg gcggttggaa tgctgagacc tatgcagcgg ttgaactgat tgaaagccat
    20521 tcaactaaag aagagttcat gacggactac cgtctttata tcgaactctt acgcaatcta
    20581 gcagatgaag caggtttgcc gaaaacgctt gatacaggga gtttagctgg aattaaaacg
    20641 cacgagtatt gcacgaataa ccaaccaaac aaccactcag accatgtgga tccataccct
    20701 tacttggcaa aatggggcat tagccgtgag cagtttaagt atgatattga gaacggcttg
    20761 acgattgaaa caggctggca gaagaatgac actggctact ggtacgtaca ttcagacggc
    20821 tcttatccaa aagacaagtt tgagaaaatc aatggcactt ggtactactt tgacagttca
    20881 ggctatatgc ttgcagaccg ctggaggaag cacacagacg gcaactggta ctggttcgac
    20941 aactcaggtg aaatggctac aggctggaag aaaatcgctg ataagtggta ctatttcaac
    21001 gaagaaggtg ccatgaagac aggctgggtc aagtacaagg acacttggta ctacttagac
    21061 gctaaagaag gcgccatggt atcaaacgcc tttatccagt cagcggacgg aacaggctgg
    21121 tactacctca aaccagacgg aacactggca gacaagccag aattcacagt agagccagat
    21181 ggcttgatta cagtaaaata ataatggaat gtctttcaaa tcagaacagc gcatattatt
    21241 aggtcttgaa aaagcttaat agtatgcgtt ttcttgtgga gatatttcct tcaatttttg
    21301 ctactatatt aaacaaaaat caaaaagcaa actagaaagt tatgctcaaa taaaatctaa
    21361 atttgacaat gtaaaccgag tcggatagct ttaagtactg ttttgaggtt gaagatacga
    21421 tttttgatag gaactcatca aataggttta atatcatcaa ttttagattt ttaagtagca
    21481 tcaataaatt gcttccttgt tttgtcataa tttttttatt taaaaaatta tgacaagagt
    21541 gtgctattct ttttatgaga ggtgtatgaa tatgataaat gtatgtgata aatgtatgtg
    21601 atgttggaaa aagaataaaa gaacttagaa tatcttcaaa tcttactcaa gataagattg
    21661 ctgagtattt gtctttgaat caaagcatga ttgccaaaat ggaaaaaggt gaaaggaata
    21721 tcacgaatgg atttaagtaa taaagctcca aatcttagaa aaaagttggg agctgatggt
    21781 gaatcgccga tagatatttt taaattggta caaaagatag aaaatttgac gctggtattt
    21841 tatggactcg gaaagaatat tagcggagtc tgttataaag gaactcagtt cagtctcatt
    21901 gcagtcaatt cagacatgtc attaggaagg taaagatttt ctttagcaca tgaactgtat
    21961 catctttatt atgatgaggt gaagaagagt tcagtcagtc ttatcttgat tggtgaagga
    22021 gatgaaactg aaagaaaagc ggatcagttt gcttcttatt ttttaatttt cccatcttca
    22081 ctgtatagga tggttgagga aatcagagaa aatgccaata gaactcatct tgaagtagaa
    22141 gatattataa aattgggtca gttttatggt atcagtcata aagctatgtt atatagattg
    22201 aggaatgatg gataccttga tgcagaagaa attaaaaata tggatattag tgttatagag
    22261 acagcttcaa gattaggcta tgatacaagt ttatatcgtc ctttgtcaga aagtaaaaag
    22321 aaatgttatt aggataatat attaatctaa ctgaacaact tttagaaaat aacagaattt
    22381 cgcaagggaa gtatgaggaa ctgttactag atgctttcag atatgatatt gtatatgggc
    22441 tagatgaaga ggggggagtt gtcgtttgac tagtcgtgta tttattgatg cagattgtat
    22501 ttcagtattt ttatgggttg gcactgaaca tcttttagaa aagctctatt tgggtaaaat
    22561 tgttattcca caagaggtgt atgatgaaat caatatacct acaattcccc atttaaaatc
    22621 taggatagat cagttggtag ctaagggttc agctgagatt gtgagcatag acattggaac
    22681 tgaagaatac gcattatata gagatttaac aagaaatcat gatagtaaca agattattgg
    22741 taagggagaa gcggcttcta tttccttagc gaaaaagcat aatgggatat taggaagtaa
    22801 taacctaaga gatgttaaat catatgtaaa agaattttct ttagaatata tgacaacagg
    22861 agatatactg gttgaagcgt ttaaagcgta atttattact gaacaagagg gcaatcatat
    22921 ctggaataat atgcttaaaa agagaaggaa aattggtgca aattcatttt cagactatct
    22981 tcgtggaagt attcatcaaa atagacaaaa ataaatttgg ataaatcgaa ctcactattc
    23041 aggaggcata tgagcaattc gaaaaagaaa agtgtcaaat tgagcctata ggagtagaag
    23101 tgaaatagta agtcctgcat agtggatgag agaaaagttc tccttgaagt tttcctgaac
    23161 tatcagtcgc atgtcaaacg atatgtaggg taatgtgaga ggggatagcg agtagttttt
    23221 ggttatttta tcaaaaaact tatattttat tataccgaat gataaaatat aataaaaatg
    23281 atagaataag gaaaaaacat gaatgtcaaa aagataatgt caatttttca atccttttat
    23341 gttgatgtca gtattgagga actgacttta ccaatcagtt ttgtaaaaaa gtttgagtat
    23401 actcaaatga cttttcataa ggaatcattt ttattgatta aagaaaagag aagggggagt
    23461 ttgagttcat ttgttactca ggctcgcact atgggtgata aagccaatat ggatgttgtt
    23521 ttggtgtttt cgaagttatc agacggtgaa aaaaaagcaa ttacttcaag ctagagttcc
    23581 gtttgtagac tttaagggaa acctcttctt ccctacattg ggactagtac tgaatgcgaa
    23641 tgatactgaa gtccctaagg aattaatacc tagcgaacaa ttaacgtgga ttgccttttt
    23701 attgacaaaa ggtcaaaaag tagtagatgt tgatttgctt tcacaagtca ctggacttcc
    23761 aaactcaaca atttataggt gtttgaggac ttttaaagct ttatatttgt taaacaagca
    23821 aaataagctt tacacatata cggtgtcaaa gaaagaatta ttcttaaaat ccgtgtcatg
    23881 tttatttaat cccatcaaaa aacggatttt attgccagat ggcgatataa agcagataaa
    23941 atctgtttct aaccttctat atggtggtgc ttatgctttg tcgcattcaa cttttttagc
    24001 tgaaacggat gaaaatatta gctatgtcat atggcagaga aaattcaatc agttaccctt
    24061 gccactttct cagcatattt taaaaggaaa gatgctagag atatggaaat atcgtccttt
    24121 tgtatctgag ttttggaatg attttaaaaa taatcatgat aaacaatttg tagatccgat
    24181 ttctctttat ttgaccttaa aagatgatga tgacccacgt atagaggaag agagtgaagc
    24241 actagaaaat atgatattac agtatctggg agaagatgat gccagctaat acgaaagtta
    24301 tttttcaaga aacgtttgcg gattttcaga actattatgt tctgattggg ggaactgcta
    24361 cctctatcgt attggattcg caaggattta aaagtcgcac aacaaaagat tatgatatgg
    24421 tcatcattga tgaagtaaaa aataaggaat tttatactac cttgaatcat tttttagaat
    24481 tgggagagta tcaaggaagt cagaaagatg agaaagcgca gctttttcga tttacaacaa
    24541 ctaatcctga gtttccttct atgattgaac tatttagtat cttaccagaa tattcattaa
    24601 agaaggacgg tcgagaaatt cccttacatt ttgaccaaga tgctagttta tcagccttat
    24661 tattggatga agattattat aatatattgg tgcatgaaaa agaaaccatt caggggtatt
    24721 cggtattgag taattgtggt c
//
LOCUS       DBMVGT010000024        23114 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.024, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000024 DBMVGT010000000
VERSION     DBMVGT010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 23114)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23114)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23114
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.024"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..128
                     /locus_tag="AC0DU4_001075"
     CDS             <1..128
                     /locus_tag="AC0DU4_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
                     /protein_id="HIN4237049.1"
                     /translation="ENIFAKVKTFKMFSTIYRNHRKRFGLRMNLIAGIINHELGF"
     gene            complement(120..763)
                     /locus_tag="AC0DU4_001076"
                     /pseudo
     CDS             complement(120..763)
                     /locus_tag="AC0DU4_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365310.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
     gene            complement(872..1390)
                     /locus_tag="AC0DU4_001077"
     CDS             complement(872..1390)
                     /locus_tag="AC0DU4_001077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013852041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ClbS/DfsB family four-helix bundle protein"
                     /protein_id="HIN4237050.1"
                     /translation="MRTYENKEELKAEIEKTFEKYILEFDNIPENLKDKRADEVDRTP
                     AENLAYQVGWTNLVLKWEEDERKGLQVKTPSDKFKWNQLGELYQWFTDTYAHLSLQEL
                     KAKLNENINSISAMIDSLSEEELFEPHMRKWADEATKTATWEVYKFIHVNTVAPFGTF
                     RTKIRKWKKIVL"
     gene            complement(1427..1555)
                     /locus_tag="AC0DU4_001078"
                     /pseudo
     CDS             complement(1427..1555)
                     /locus_tag="AC0DU4_001078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001267199.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CD1845 family protein"
     gene            complement(1617..2486)
                     /gene="rsmI"
                     /locus_tag="AC0DU4_001079"
     CDS             complement(1617..2486)
                     /gene="rsmI"
                     /locus_tag="AC0DU4_001079"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0000451 - rRNA 2'-O-methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HIN4237051.1"
                     /translation="MQIQKSFKGQSPYGKLYLVATPIGNLDDMTFRAIQTLKEVDWIA
                     AEDTRNTGLLLKHFDISTKQISFHEHNAKEKIPDLIGFLKAGQSIAQVSDAGLPSISD
                     PGHDLVKAAIEEEIAVVTVPGASAGISALIASGLAPQPHIFYGFLPRKSGQQKQFFGL
                     KKDYPETQIFYESPHRVADTLENMLEVYGDRSVVLVRELTKIYEEYQRGTISELLESI
                     AETPLKGECLLIVEGASQGVEEKDEEDLFVEIQTRIQQGVKKNQAIKEVAKIYQWNKS
                     QLYAAYHDWEEKQ"
     gene            complement(2489..2806)
                     /gene="yabA"
                     /locus_tag="AC0DU4_001080"
     CDS             complement(2489..2806)
                     /gene="yabA"
                     /locus_tag="AC0DU4_001080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication initiation control protein YabA"
                     /protein_id="HIN4237052.1"
                     /translation="MDKKELFDALDDFSQQLLVTLADVEAIKKNLKSLVEENTALRLE
                     NSKLRERLGEVEADAPVKAKHVRESVRRIYRDGFHVCNDFYGQRREQDEECMFCDELL
                     YRE"
     gene            complement(2846..3736)
                     /locus_tag="AC0DU4_001081"
     CDS             complement(2846..3736)
                     /locus_tag="AC0DU4_001081"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HIN4237053.1"
                     /translation="MKQDQLKAWQPAQFDRFVRILEQDQLNHAYLFSGFFGSLEMAQF
                     LAKSLFCTDKVGVLPCEKCRSCKLIEQEEFPDVTLIKPVNQVIKTERIRELVGQFSQA
                     GIESQQQVFIIEQADKMHPNAANSLLKVIEEPQSEVYIFFLTSDEEKMLPTIRSRTQI
                     FHFKKQEEKLILLLEQMGLVKKKATLLAKFSQSRAEAEKLANQASFWTLVDESERLLT
                     WLVAKKKESYLQVAKLANLADDKEKQDQVLRILEVLCGQDLLQVRVRVILQDLLEARK
                     MWQANVSFQNAMEYLVLKEI"
     gene            complement(3733..4371)
                     /gene="tmk"
                     /locus_tag="AC0DU4_001082"
     CDS             complement(3733..4371)
                     /gene="tmk"
                     /locus_tag="AC0DU4_001082"
                     /EC_number="2.7.4.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004798 - dTMP kinase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006233 - dTDP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dTMP kinase"
                     /protein_id="HIN4237054.1"
                     /translation="MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVKVLTTREPGGV
                     LIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSS
                     VAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDL
                     EGLELHKKVRQGYLSLLEKEGNRIVKIDASLPLEQVVETTKAVLFDGMDLAK"
     gene            complement(4591..5388)
                     /gene="proC"
                     /locus_tag="AC0DU4_001083"
     CDS             complement(4591..5388)
                     /gene="proC"
                     /locus_tag="AC0DU4_001083"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004735 - pyrroline-5-carboxylate
                     reductase activity [Evidence IEA];
                     GO_process: GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HIN4237055.1"
                     /translation="MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIAD
                     FGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKL
                     ASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFYQLLAKAGLLVELGES
                     LIDAATGLAGCGPAFVYLFIEALADAGVQTGLPREIALKMAAQTVVGAGQLVLESQQH
                     PGVLKDQVCSPGGSTIAGVASLEAHAFRGTVMDAVHQAYKRTQELGK"
     gene            complement(5392..6654)
                     /locus_tag="AC0DU4_001084"
     CDS             complement(5392..6654)
                     /locus_tag="AC0DU4_001084"
                     /EC_number="1.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004350 - glutamate-5-semialdehyde
                     dehydrogenase activity [Evidence IEA];
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA];
                     GO_process: GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate-5-semialdehyde dehydrogenase"
                     /protein_id="HIN4237056.1"
                     /translation="MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEI
                     LAANALDMAAAKGKISDVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLEN
                     GLVITKKRVAIGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
                     KKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPV
                     IETGTGIVHVYVDKDADEDKALSIINNAKTSRPSVCNAMEVLLVHENKAASILPRLDQ
                     MLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVA
                     HIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQ
                     KLHARGPMGLKELTSYKYVVAGDGQIRE"
     gene            complement(6664..7773)
                     /gene="proB"
                     /locus_tag="AC0DU4_001085"
     CDS             complement(6664..7773)
                     /gene="proB"
                     /locus_tag="AC0DU4_001085"
                     /EC_number="2.7.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004349 - glutamate 5-kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 5-kinase"
                     /protein_id="HIN4237057.1"
                     /translation="MKYKRIVFKVGTSSLTNEDGSLSRSKVKDITQQLAMLHEAGHEL
                     ILVSSGAIAAGFGALGFKKRPTKIADKQASAAVGQGLLLEEYTTNLLLRQIVSAQILL
                     TQDDFVDKRRYKNAHQALSVLLNRGAIPIINENDSVVIDELKVGDNDTLSAQVAAMVQ
                     ADLLVFLTDVDGLYTGNPNSDPRAKRLERIETINREIIDMAGGAGSSNGTGGMLTKIK
                     AATIATESGVPVYICSSLKSDSMIEAAEETEDGSYFVAQEKGLRTQKQWLAFYAQSQG
                     SIWVDKGAAEALSQHGKSLLLSGIVEAEGAFSYGDIVTVFDKESGKSLGKGRVQFGAS
                     ALEDMLRSQKAKGVLIYRDDWISITPEIQLLFTEF"
     gene            complement(7874..9757)
                     /gene="cbpE"
                     /locus_tag="AC0DU4_001086"
                     /gene_synonym="pce"
     CDS             complement(7874..9757)
                     /gene="cbpE"
                     /locus_tag="AC0DU4_001086"
                     /gene_synonym="pce"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine esterase CbpE"
                     /protein_id="HIN4237058.1"
                     /translation="MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSD
                     AIILESNGHFAMVDTGEDYDFPDGSDSRYPWREGIETSYKHVLTDRVFRRLKELGVQK
                     LDFILVTHTHSDHIGNVDELLSTYPVDRVYLKKYSDSRITNSERLWDNLYGYDKVLQT
                     AAEKGVSVIQNITQGDAHFQFGDMDIQLYNYENETDSSGELKKIWDDNSNSLISVVKV
                     NGKKIYLGGDLDNVHGAEDKYGPLIGKVDLMKFNHHHDTNKSNTKDFIKNLSPSLIVQ
                     TSDSLPWKNGVDSEYVNWLKERGIERINAASKDYDATVFDIRKDGFVNISTSYKPIPS
                     FQAGWHKSAYGNWWYQAPDSTGEYAVGWNEIEGEWYYFNQTGILLQNQWKKWNNHWFY
                     LTDSGASAKNWKKIAGIWYYFNKENQMEIGWIQDKEQWYYLDVDGSMKTGWLQYMGQW
                     YYFAPSGEMKMGWVKDKETWYYMDSTGVMKTGEIEVAGQHYYLEDSGAMKQGWHKKAN
                     DWYFYKTDGSRAVGWIKDKDKWYFLKENGQLLVNGKTPEGYTVDSSGAWLVDVSIEKS
                     ATIKTTSHSEIKESKEVVKKDLENKETSQHESVTNFSTSQDLTSSTSQSSETSVNKSE
                     SEQ"
     gene            complement(9760..10647)
                     /locus_tag="AC0DU4_001087"
     CDS             complement(9760..10647)
                     /locus_tag="AC0DU4_001087"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HIN4237059.1"
                     /translation="MEIKIETGGLRLDKALSDLSELSRSLANEQIKSGQVLVNGQVKK
                     AKYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVYQDEDVAVVNKPQGMVVHPSAGHTS
                     GTLVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGLLMIAKNDDAHLALAQELKDKKS
                     LRKYWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAKGKPAVTRFHVLERFGDYSLV
                     ELQLETGRTHQIRVHMAYIGHPVAGDEVYGPRKTLKGHGQFLHAKTLGFTHPRTGKTL
                     EFKADIPEIFKETLERLRK"
     gene            complement(10637..11098)
                     /gene="lspA"
                     /locus_tag="AC0DU4_001088"
     CDS             complement(10637..11098)
                     /gene="lspA"
                     /locus_tag="AC0DU4_001088"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HIN4237060.1"
                     /translation="MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSL
                     TYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLG
                     NFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN"
     gene            complement(11095..12003)
                     /locus_tag="AC0DU4_001089"
     CDS             complement(11095..12003)
                     /locus_tag="AC0DU4_001089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HIN4237061.1"
                     /translation="MNIQQLRYVVAIANSGTFREAAEKMYVSQPSLSISVRDLEKELG
                     FKIFRRTSSGTFLTRRGMEFYEKAQELVKGFDIFQNQYANPEEEKDEFSVASQHYDFL
                     PPTITAFSERYPDYKNFRIFESTTVQILDEVAQGHSEIGIIYLNNQNKKGIMQRVEKL
                     GLEVIELIPFHTHIYLCEGHPLAQKEELVMEDLADLPTVRFTQEKDEYLYYSENFVDT
                     SASSQMFNVTDRATLNGILERTDAYATGSGFLDSDSVNGITVIRLKDNLDNRMVYVKR
                     EEVELSQAGTLFVEVMQEYFDQKRKS"
     gene            12032..12193
                     /locus_tag="AC0DU4_001090"
     CDS             12032..12193
                     /locus_tag="AC0DU4_001090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_function: GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HIN4237062.1"
                     /translation="MIPYFRSFPKRKKEHPILLNYLHYLPFSSQPYFQNQFKKITGYT
                     PLQYRKEKR"
     gene            complement(12245..12916)
                     /locus_tag="AC0DU4_001091"
     CDS             complement(12245..12916)
                     /locus_tag="AC0DU4_001091"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
                     /protein_id="HIN4237063.1"
                     /translation="MKKRAIQILLALSLIFYKSTWFWRVFNHLAKPYLPASREFFQIL
                     LLMESGVLFLAVIYLLVFAGKKIFHFKWQLRYFIYLLLGYIISYMSDFLFSYFISLSS
                     NQISLNETVEMMGRQEFPYFLLIVCFIAPIAEELIYRGVIMTTFFKNSPWYGDVLLSA
                     IIFGYIHINFALTPLAFFIYASGGLILALLYRMTKNLYYPILVHILINITAFWDVWLL
                     LFSGS"
     gene            complement(12970..13191)
                     /locus_tag="AC0DU4_001092"
     CDS             complement(12970..13191)
                     /locus_tag="AC0DU4_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000602450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0924 family bacteriocin-like peptide"
                     /protein_id="HIN4237064.1"
                     /translation="MILMTKNINLTNEELELIQGGADSYGKNPNGRYDWEIEPVLTLP
                     VHGFCPRGTYDLGYIGGGNHLCKGSAARF"
     gene            13463..14272
                     /locus_tag="AC0DU4_001093"
     CDS             13463..14272
                     /locus_tag="AC0DU4_001093"
                     /EC_number="3.-.-.-"
                     /EC_number="3.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HIN4237065.1"
                     /translation="MIKLLALDMDGTLLNEAKEIPQAHIAAIHQAIEKGVKLVLCTGR
                     PLFGVLPYYKKLGLDLQNEYVIVNNGCSTHQTSDWGLVDWQELSPADIEYLYDLAEKS
                     DVQLTLFDESHYFVLGGKPNQVIENDAKLVFSDLTEISLEEATSGKFRMFQGMFLGTK
                     EQTDDFEQRFAEELCQRFSGVRSQPVIYEAMPLGTTKATALSRLAEILKIDSSEIMAM
                     GDANNDIEMLQFAGLGIAMGNASDYVKSLADAVTSSNEEDGVARAIEKYIL"
     gene            complement(14453..15328)
                     /gene="aguB"
                     /locus_tag="AC0DU4_001094"
     CDS             complement(14453..15328)
                     /gene="aguB"
                     /locus_tag="AC0DU4_001094"
                     /EC_number="3.5.1.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001246759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0050126 - N-carbamoylputrescine amidase
                     activity [Evidence IEA];
                     GO_process: GO:0009446 - putrescine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-carbamoylputrescine amidase"
                     /protein_id="HIN4237066.1"
                     /translation="MRNVRVATIQMQCAKDVATNIQTAERLVRQAAEQGAQIILLPEL
                     FEHPYFCQERQYDYYQYAQSVAENTAIQHFKVLAKELQVVLPISFYEKDGNVLYNSIA
                     VIDADGEVLGVYRKTHIPDDHYYQEKFYFTPGNTGFKVWNTRYAKIGIGICWDQWFPE
                     TARCLALNGAELLFYPTAIGSEPILDTDSCGHWQRTMQGHAAANIVPVIAANRYGLEE
                     VTPSEENGGQSSSLDFYGSSFMTDETGAILERAERQEEAVLLATYDLDKGASERLNWG
                     LFRDRRPEMYRQITD"
     gene            complement(15338..16423)
                     /gene="aguA"
                     /locus_tag="AC0DU4_001095"
     CDS             complement(15338..16423)
                     /gene="aguA"
                     /locus_tag="AC0DU4_001095"
                     /EC_number="3.5.3.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0047632 - agmatine deiminase activity
                     [Evidence IEA];
                     GO_process: GO:0009446 - putrescine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="agmatine deiminase"
                     /protein_id="HIN4237067.1"
                     /translation="MMDSPKKLGYHMPAEYEPHHGTLMIWPTRPGSWPFQGKAAKRAF
                     TQIIETIAEGERVYLLVEQAYLSEAQSYLGDKVVYLDIPTNDAWARDTGPTILVNDKG
                     KKLAVDWAFNAWGGTYDGLYQDYEEDDQVASRFAEALERPVYDAKPFVLEGGAIHSDG
                     QGTILVTESCLLSPGRNPNLTKEEIENTLLESLGAEKVIWLPYGIYQDETNEHVDNVA
                     AFVGPAELVLAWTDDENDPQYAMSKADLELLEQETDAKGCHFTIHKLPIPAVRQVVTE
                     EDLPGYIYEEGEEKRYAGERLAASYVNFYIANKAVLVPQFEDVNDQVALDILSKCFPD
                     RKVVGIPARDILLGGGNIHCITQQIPE"
     gene            complement(16420..17547)
                     /gene="nspC"
                     /locus_tag="AC0DU4_001096"
     CDS             complement(16420..17547)
                     /gene="nspC"
                     /locus_tag="AC0DU4_001096"
                     /EC_number="4.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016831 - carboxy-lyase activity [Evidence
                     IEA];
                     GO_process: GO:0045312 - nor-spermidine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carboxynorspermidine decarboxylase"
                     /protein_id="HIN4237068.1"
                     /translation="MKLEQVPTPAYVIDLAKLEANCRILQYVQEEAGCKVLLAQKAYS
                     LYKTYPLISQYLSGTTASGLYEAKLAREEFPGEVHVFAPAFKDADLEELLEIMDHIVF
                     NSERQLRKHGPRCREAGVSVGLRLNPQCSTQGDHALYDPCAPGSRFGVTIDKIPSDLL
                     DLVDGLHFHTLCEQGADDLQTTLKAVEEQFGPYLHEVKWLNMGGGHHITREGYDVDLL
                     ISEIKRIRKTYNLEIYIEPGEAIALNAGYLATEVLDIVENGMEILVLDASATCHMPDV
                     LEMPYRPPLRNGFESQEKAHTYRLSSNTCLTGDVIGDYSFENPVQIGDRLYFQDMAIY
                     SFVKNNTFNGIGLPSLYLMDEQGDCSLLKAFGYQDFKGRLS"
     gene            complement(17547..18806)
                     /locus_tag="AC0DU4_001097"
     CDS             complement(17547..18806)
                     /locus_tag="AC0DU4_001097"
                     /EC_number="1.5.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000088792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_function: GO:0070403 - NAD+ binding [Evidence IEA];
                     GO_process: GO:0009085 - lysine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="saccharopine dehydrogenase family protein"
                     /protein_id="HIN4237069.1"
                     /translation="MSRLLVIGCGGVAQVAISKICQDSETFTEIMIASRTKSKCDDLK
                     AKLEGKTSTKIETAALDADKVEEVIALIESYKPEAVLNVALPYQDLTIMDACLATGVH
                     YIDTANYEAEDTEDPEWRAIYEKRCKELGFTAYFDYSWQWAYQEKFKEAGLTALLGSG
                     FDPGVTSVFSAYALKHYFDEIHYIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYW
                     EDGKWVEVEAMSIKREYDFPQVGQKDMYLLHHEEIESLAKNIPGVKRIRFFMTFGQSY
                     LTHMKCLENVGLLRTDTINFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGV
                     KDGVKKTIYIYNVCDHQECYAEVGSQAISYTTGVPAMIGTKLVMNGTWKQAGVYNLEE
                     LDPDPFMEALNEYGLPWVVVENPQMVD"
     gene            complement(18803..19663)
                     /gene="speE"
                     /locus_tag="AC0DU4_001098"
     CDS             complement(18803..19663)
                     /gene="speE"
                     /locus_tag="AC0DU4_001098"
                     /EC_number="2.5.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyamine aminopropyltransferase"
                     /protein_id="HIN4237070.1"
                     /translation="MDLWFSEVHTPDVKLSLRTAKQLYAGKSEWQDIEVLDTPAFGKI
                     LILNGHVLFSDADDFVYNEMTVHVPMAVHPNPKKVLVIGGGDGGVAQVLTLYPELEQI
                     DIVEPDEMLVEVCREYFPDFAAGLDDPRVTIYYQNGLRFLRNCEDDYDIIINDATDPF
                     GHTEGLFTKEFYGNSYRALKEDGIMIYQHGSPFFDEDESACRSMHRKVNQAFPISRVY
                     QAHIPTSPAGYWLFGFASKKYHPVKDFDKEGWKKRQLFTEYYTANLHVGAFMLPKYVE
                     DILEEEEGKK"
     gene            19918..20522
                     /locus_tag="AC0DU4_001099"
                     /pseudo
     CDS             19918..20522
                     /locus_tag="AC0DU4_001099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001826497.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA];
                     GO_process: GO:0015074 - DNA integration [Evidence IEA];
                     GO_process: GO:0032196 - transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            20511..20627
                     /locus_tag="AC0DU4_001100"
                     /pseudo
     CDS             20511..20627
                     /locus_tag="AC0DU4_001100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812181.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(20599..22074)
                     /locus_tag="AC0DU4_001101"
     CDS             complement(20599..22074)
                     /locus_tag="AC0DU4_001101"
                     /EC_number="4.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000661022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HIN4237071.1"
                     /translation="MKELDQNQAPIYEALVKLRKKRIVPFDVPGHKRGRGNPELVELL
                     GEKCVGIDVNSMKPLDNLGHPISIIRDAEELAADAFGASHAFLMIGGTTSSVQTMILA
                     TCKAGDKIILPRNVHKSAINALVLCGAIPIYIEMSVDPKIGIALGLENDRVAQAIKDH
                     PDAKAILINNPTYYGICSDLKGLTEMAHEAGMMVLVDEAHGAHLHFTGKLPISAMDAG
                     ADMAAVSMHKSGGSLTQSSLLLIGEQMNPEYVRQIINLTQSTSASYLLMASLDISRRN
                     LALRGKESFEEVIELSEYARHEINAIGGYYAYSKELIDGVSVCDFDVTKLSVYTQGIG
                     LTGIEVYDLLRDEYDIQIEFGDIGNILAYISIGDRIQDIERLVGALADIKRLYSRDGK
                     DLIAGEYIQPELVLSPQEAFYSERKSLTLDESVGQVCGEFVMCYPPGIPILAPGERIT
                     REIVDYIQFAKERGCSLQGTEDPEVNHINVIKRKTNYKKSQ"
     gene            22781..>23114
                     /locus_tag="AC0DU4_001102"
     CDS             22781..>23114
                     /locus_tag="AC0DU4_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237072.1"
                     /translation="MQDNYTTKAKHLTIDSRRLIERWKKEGKSNREIASLLGKVPQTI
                     HTEIKRGTVRQCLGKGRFKEVYSADYAQQSYENNRKRSVRKSSVTKELKEKILHYHNQ
                     KFSPEMMVM"
BASE COUNT         6744 a         5297 c         4145 g         6928 t
ORIGIN      
        1 ttgagaacat ctttgccaaa gtaaaaacgt ttaaaatgtt ttcaacaatc tatcgaaatc
       61 atcgtaaacg cttcggatta cgaatgaatt tgattgctgg cattatcaat catgaactag
      121 gattctagtt ttgcaggaag tctaatgtaa ttctcaagct gtgagttcat tatgatttgt
      181 aaatccgata tatcttcagc agctaaaaac acattttgaa atgttccaag tccgttttca
      241 ccaaaactat attctctctt actatactta ctcttattat tctctatata gttagagtca
      301 aggttcttaa cctcttgaag ttcattttct ttacttctga ggttaaaatc ttttacttct
      361 gaagttaagt tttttgactt ctgtaagtca ttttctttta cctgaaatat actcataaag
      421 tctttaacat aaatgatgtt cggcttacca agtccaagcc ttactctttc gatcagtcct
      481 attccttttt tacatcaagc tcatctaatg tttttatggc agttggcttt gagatatttc
      541 ttcttttcat aatttcttcg acagtaaaat agataaatac tctgccttcc ttgtctatcc
      601 agttattctt aaatgacatt cctgtctgtt taagaagtat ggaataaagg ataattgctt
      661 ctgctgataa gccccgaaat tcttctctat caactaatat ctccggtact tttaagaagt
      721 taaatctttc cgcttctctg ttataaaaat attcaaagtc catgcaagat cacctccctt
      781 cttaaaaatt tgcaaagaaa aagacgatag tttttcttct atcgcctttg gtaaccattt
      841 ttatgaaatt ttttaaagtt aaaaatataa tttataatac tatcttcttc cattttctga
      901 ttttagttct gaaagttcca aaaggtgcaa ccgtatttac atgaataaac ttatacactt
      961 cccaagtcgc tgttttagtc gcttcatcag cccactttct catatgcggt tcaaataatt
     1021 cttcctcact caacgaatca atcattgcag agatagaatt aatattttca tttaattttg
     1081 ctttcaactc ttgcagagat aaatgagcgt aggtatctgt gaaccactga tataattcac
     1141 caagttgatt ccatttaaat ttatccgatg gtgtttttac ttgaagcccc tttctttcat
     1201 cttcttccca tttaagaacc aagttggtcc aaccaacctg ataagcaagg ttttctgctg
     1261 gagttctgtc aacttcatca gctctcttat cttttaaatt ttctggaata ttatcaaatt
     1321 ctaaaatata tttctcaaat gttttctcta tctcagcttt tagttcttct ttattttcgt
     1381 atgttcgcaa aaaatcacct tctttctgat ttatcaatcc tttgatttaa aatgacctta
     1441 tttttctatt tataccttct aagaacgcta taactgctgc tccaaccatc ggtattccgt
     1501 atgggcttaa taaaaaactt aataccaaag cttctatacc aagtgataca tctttatatt
     1561 atcatcacta attaagttaa acagaaacag acagaattat tacatcctgt ctccctttat
     1621 tgtttttctt cccagtcgtg gtaggcagcg tagagctgac ttttattcca ctggtaaatc
     1681 ttagcgactt ccttgatagc ttggtttttc ttcacacctt gctggatgcg ggtttgaatt
     1741 tctacgaaca agtcttcctc gtccttttcc tccacaccct gactggcacc ctcaacaatg
     1801 agaagacatt cgcccttgag tggcgtttca gcaatgcttt ctaataactc agagatagta
     1861 cctcgttggt attcttcata gattttggtc aattccctga ccaagacaac ggagcggtca
     1921 ccgtagactt ctaacatatt ttccaacgtg tctgctacac gatgaggtga ttcataaaaa
     1981 atctgtgttt caggataatc ttttttcaag ccaaaaaatt gcttctgctg acctgatttt
     2041 ctcggtaaaa aaccgtaaaa gatatgtggc tgtggcgcta aaccactggc aatcaaggca
     2101 gaaattcctg cagaggcacc tggaactgtc acaactgcaa tttcttcctc aatagctgcc
     2161 ttaactaaat catgaccagg gtctgaaatg ctaggcaaac cggcatcaga gacctgagca
     2221 atactttgcc ctgctttcaa gaaaccaatc aaatcaggaa ttttttcctt ggcattgtgc
     2281 tcatgaaaac tgatctgctt ggtggaaatg tcaaaatgct tgagcaaaag ccctgtattg
     2341 cgcgtatcct cagcagcaat ccagtccact tctttcaagg tctggatagc acgaaaagtc
     2401 atatcatcta gattgccaat cggcgttgcc actagataca gcttgccata gggagactgc
     2461 cccttaaaac ttttttgaat ttgcatgctt actccctgta taacaactca tcacagaaca
     2521 tacattcttc gtcctgctct cgacgttgtc cataaaaatc attacatacg tgaaatccat
     2581 cacggtaaat acgacggaca ctttcgcgaa catgcttggc cttgacggga gcgtctgctt
     2641 ccacctcacc caagcgttct cgcaacttac tattttccaa gcgaagagct gtattttctt
     2701 ctaccaagct cttgagattt ttcttgatgg cttccacatc ggctaaggtt accaataatt
     2761 gttgggaaaa atcatccagc gcgtcaaata attctttttt gtccataaaa cagccctttc
     2821 ctttctttat cattcatttt tgagtttata tttctttcaa gaccagatat tccatggcat
     2881 tttgaaagct gacattagct tgccacattt ttctagcttc tagtaaatct tgtagaatca
     2941 ctcttactct tacctgcaag aggtcctgcc cacagagaac ttcaagaatc cgtaaaacct
     3001 gatcctgttt ttccttatca tctgccaagt tggctaattt ggcaacctgt agataacttt
     3061 cttttttctt agctactaac caagtcagca ggcgttcact ttcatcgacc aaggtccaaa
     3121 aacttgcctg attagccaac ttttctgctt cagctcgcga ttgactaaac ttagctaaaa
     3181 gagtcgcttt tttcttaaca agtcccattt gttctaagag taagataagt ttttcttctt
     3241 gctttttaaa gtggaagatc tgagtccgac ttcggattgt cggtaacatc ttttcctcat
     3301 cgctagtcaa gaagaaaata taaacttcac tctggggttc ttcgatgacc ttgagcagag
     3361 aattggctgc gttgggatgc attttatccg cttgctcgat aataaagacc tgttgctggc
     3421 tttcaatccc tgcttgagaa aactgtccca ccaattcccg aatgcgttct gtcttgatga
     3481 cctgattgac tggcttaatc aaggtgacat ctggaaactc ttcctgttca atcagcttgc
     3541 aacttcggca tttctcacat ggtaagacgc caactttatc cgtacaaaag aggctcttag
     3601 ctaaaaattg cgccatttcc aagcttccaa agaaacctga aaagagatag gcgtgattga
     3661 gctggtcttg ttctaagata cggacaaaac ggtcaaactg agctggttgc caagccttta
     3721 gttgatcttg tttcatttgg ccaagtccat tccgtcaaac aagacagcct tggtagtttc
     3781 cacaacttgc tccaaaggga gactagcatc aatcttgaca atgcgatttc cttctttttc
     3841 caggagagaa aggtagcctt gacggacttt cttgtgcaat tccaaacctt ccaagtccag
     3901 acgattgacc tcgcggtcac tattcgcagc aatgcgagcc agcccttctt ccacctcgat
     3961 gtcaaaatag agtgtcaaat cgggtttgag gccatctgtc gcaaactgat tgagccagtc
     4021 aatggcttca atatctaagc cacgaccaaa tccctgatag gcaacagaac tatcgataaa
     4081 acgatccatg atgaccaact tgccagcttc aagggctgga agaacttttt ccaccaaatg
     4141 ctgtctgcga ctggcaatat agagaagtag ctctgtttta gcatccatct gagtatgact
     4201 tggatccaaa atcacttccc gaatcttctc cccaatcaag actccgccag gttcacgggt
     4261 cgtcagcacc tttactcctt tttcctctaa aattggtagc agagcctcta aaacactggt
     4321 cttgcctgct ccctctggtc cctcaagaga gactaaaaat ccttttgaca tgtctaactc
     4381 atttcttttt tactacttct attctatcaa aaaaataggg gtttgtgaca atctttttgt
     4441 cttctcattt catactcaat gaaaatcaaa gagcaaacta ggaagctagc cgcaggctgt
     4501 acttgagtac ggcaaggtga agctgacgca gtttgaattt gattttcgaa gagtatcaac
     4561 caccataaaa gaggcagata aaactacctc ttatttacct agttcttgtg ttcgtttgta
     4621 ggcttgatga actgcatcca tgactgttcc tcggaaagca tgcgcttcta ggcttgctac
     4681 accagcgata gtcgaaccgc ctgggctaca gacttggtct ttcaatactc caggatgttg
     4741 ctgactttca aggaccaatt gcccagctcc taccacagtt tgtgctgcca ttttcaatgc
     4801 tatttctcgt ggtaatcctg tctgaacacc tgcatctgcc aaggcctcga taaaaagata
     4861 gacaaaggct ggtccacaac ctgcaagacc tgtcgctgca tcgattaaac tttctcctag
     4921 ttcaaccaag agaccagcct tggctaaaag ctgataaaag agctcactgt cctcagccct
     4981 gcaattagga gacaaggcat aactaatcac tccttgcccg atagaagcag gggtattagg
     5041 catcatacga ataattcggt gttgacttgg gataagactt gctagttttt ctaaggtcaa
     5101 tccagctgcc atcgaaatca aaagaagact ttctcttttt tcaaggatgg tctggtattg
     5161 agaaagcagt tcagaaaact gagcaggctt aactcctaga aaaatcacat ctgcttctgc
     5221 aaacatttct tcattgctgg aagcctgacc accaaagtct gcaatgaaag catctacctt
     5281 agcttgacta cgattggcaa ggagaatctc atctgacgtc ctagtctgca agacagattt
     5341 tgccaagcta gcacccatat tccccaaacc gataaatcca atcttcatct cttactccct
     5401 tatctgccca tcaccggcaa ccacatactt gtagctggtc aactctttca agcccatggg
     5461 accacgcgcg tgcaatttct gagtagaaat ccccatttca caaccaagac caaattgtcc
     5521 tccatctgtg aaacgagttg aggcattaac atacaccgct gcagagtcca cttgatctgt
     5581 aaagtatgct gcagcttcag cattttccgt cacaatagca tccgaatgat gggtgctgtg
     5641 ggattcaatg tgcgcaaccg cttcttctaa actgctcaca accttaacag caaggacata
     5701 gtctaaaaac tcggtgtcaa agtcttgggt ctcagctgct tgacctgaaa caaactggct
     5761 tgctttgcta tccaagcgga attgaattgg ttccagtcca gcttccttac gctctgcaac
     5821 cagcatttga tccaagcgag gaaggatgct tgctgccttg ttttcatgaa ccagcagaac
     5881 ctccatggca ttacaaacag aaggacgact ggttttagca ttgttgatga tagacagcgc
     5941 cttgtcttcg tctgcatcct tatccacata gacatggaca atcccagtcc ctgtctcgat
     6001 aacaggtaca atcgcattct caaccactgc attgatcaag ccagctcctc cacgaggaat
     6061 gagaaggtct agatagccct tggccttcat catagcataa ctactttcac ggctagtatc
     6121 ctccaccagt tgaatcacat ttggatgaat agtagtcgtc tccaagccct tcttcaaggc
     6181 tgtgacaatg gcatgggttg tttgataggc atccttacca ctacgaagaa caaccgcatt
     6241 tccactctta agagtcaaag cagccgcatc agacgtcaca tttggacggc tttcatagat
     6301 aataccgatg acacctatag ctacacgttt ttttgtgata accaaaccat tttcaagctg
     6361 acttgtttct aaaacttcac cgattggatc tggtaaggca accacttcac gaattcctct
     6421 tgccatcgct tctatacgat ctgcatccaa ataaagacga tccaacatca catctgagat
     6481 tttcccctta gccgctgcca tatcgagggc attagccgct aaaatttcct cagtagcagc
     6541 cactaagtga tcagccatgg ctagcaaggc ttggtttttc acttcttcac tagctgtgtt
     6601 aatcgatttt ttaacagcct gtacctgttc aaattgttct tgtctactca ccatagttta
     6661 cctctaaaat tctgtaaaaa gtagttggat ttcaggagta atggaaatcc agtcgtcacg
     6721 gtaaatcaag acacccttgg ctttttgaga acgcaacata tcctccaaag cagatgctcc
     6781 aaattgcacg cgtccttttc caagtgattt tccactttcc ttgtcaaata ctgtcacgat
     6841 atcaccgtaa gaaaaggctc cttctgcttc aacgatacca gataagagaa gactctttcc
     6901 atgttgagag agagcttccg cagccccttt atcaacccaa atagaacctt gactctgagc
     6961 atagaaggca agccattgtt tctgggtacg aagccccttc tcttgagcaa caaagtaaga
     7021 accatcctcg gtctcctctg ccgcctcaat catggaatct gatttcaagg atgagcagat
     7081 ataaacagga actcctgatt ccgtcgcgat agttgcagcc ttgattttgg ttaacatacc
     7141 cccagttccg tttgacgaac cagctccacc agccatatca ataatctcac gattgatggt
     7201 ctcgattctc tccaagcgtt tggctcttgg atctgaatta ggatttccag tatagagacc
     7261 gtccacatct gtcaagaaaa ctaaaaggtc tgcttggacc atcgccgcta cttgagcact
     7321 tagagtgtca ttgtccccaa ccttgagctc atcaataacg acactatcat tctcattgat
     7381 gataggaatt gccccacggt tgagcaaaac cgacaaagcc tgatgggcat ttttataacg
     7441 acgcttatcc acaaagtcat cttgggtcag caagatttgt gcagaaacga tttgacgcaa
     7501 gagaagattg gtcgtatatt cttccaacaa aagtccctgc cctaccgctg ctgaagcctg
     7561 tttatcagca attttagtcg gacgcttttt aaatcctaag gctccaaaac cagccgcaat
     7621 ggcacctgaa gacaccaaaa tcaactcatg accagcctcg tgcagcatag ccaactgctg
     7681 ggtaatatcc tttaccttac tacgtgataa acttccatcc tcatttgtca gagaagaagt
     7741 acccacctta aagacaatcc gtttgtattt catagtctca ctccgattat tcatatttat
     7801 ccattataac atgaataaca ggaaatagaa aagagttgat aggaaaaaga aggccctaaa
     7861 accttctttt ctactactgt tctgattccg atttgtttac actcgtttca gagctttgtg
     7921 aagttgagga tgtcaaatct tgactagttg aaaaatttgt aacactttca tgttgactcg
     7981 tttctttatt ttcaagatcc tttttcacta cttctttgga ttcttttatt tctgaatgac
     8041 ttgtagtttt aattgtagca gatttctcga tcgaaacatc cactaaccag gcaccacttg
     8101 aatccacagt ataaccttct ggtgtcttac cgttcacaag taattgacca ttttctttca
     8161 agaagtacca tttatccttg tccttgatcc aacccacagc tcgtgaaccg tctgtcttgt
     8221 agaaatacca atcatttgcc tttttatgcc agccttgctt catagctcct gaatcttcca
     8281 gataataatg ttgaccagca acttctatct cacctgtctt catgacacca gtagaatcca
     8341 tatagtacca ggtttcttta tcttttaccc agcccatttt catttcccct gatggagcaa
     8401 agtaatacca ttgccccata tattgaagcc atcctgtctt catagaacca tcaacatcca
     8461 aataatacca ctgctcttta tcttgaatcc aaccaatttc catctggttt tctttgttaa
     8521 aataatacca gattccagcg attttcttcc aatttttagc agaagcacca gagtctgtca
     8581 aatagaacca atgattgttc cattttttcc attgattctg taacaagata cccgtttggt
     8641 taaagtaata ccattcacct tcgatttcat tccaaccgac agcatactct cctgtagaat
     8701 caggcgcttg ataccaccag ttcccatatg cactcttatg ccaaccagct tgaaaacttg
     8761 gaatcggctt gtaggatgtt gaaatattga caaaaccgtc ttttcgaata tcaaaaactg
     8821 ttgcatcata gtctttgctg gctgcgttga ttctctcaat tcctcgttct ttgagccaat
     8881 taacatactc actatcaaca ccatttttcc aaggtagact atccgaagtt tgaacaatca
     8941 aactcggact caaattttta atgaaatcct tggtatttga tttgttggta tcatggtgat
     9001 gattaaactt catcaaatca acttttccaa tgagaggacc atacttgtct tctgctccat
     9061 gaacattatc taaatcgccc ccaaggtaaa ttttcttgcc attgactttc accacgctaa
     9121 tcaaggaatt ggaattgtca tcccaaattt tctttaattc acccgatgaa tcagtttcat
     9181 tttcataatt atagagctga atatccatgt ccccaaactg aaaatgagca tccccttgtg
     9241 tgatattttg aataactgaa acaccttttt ctgcagcagt ctgtaaaacc ttatcatagc
     9301 catacagatt atcccataga cgttcagaat tagtaatacg actatcacta tatttcttaa
     9361 gatagactcg gtcaactgga taggtagaca gtaattcatc aacatttcca atatgatcac
     9421 tgtgggtatg ggtcaccaaa ataaaatcaa gtttttggac acccaattcc ttcaaacgac
     9481 gaaagacacg gtctgttaga acatgcttat aagacgtttc aattccttct ctccatggat
     9541 agcgagaatc acttccatct gggaaatcat aatcttctcc tgtatccacc atggcaaaat
     9601 gtccattgct ttcaagaata atcgcatcac tgccaccttc ttgaacattg ataaagtgga
     9661 ttttatttcc tgaactttct tgagcctgaa cattcccata ccatgacaaa cctaaaaaag
     9721 cgcctacaag tgctaaacta gttaatttct ttttcattct tactttctca atctctccaa
     9781 ggtttcctta aaaatctctg ggatatctgc tttaaattcc aaggtcttac ctgttctcgg
     9841 atgagtaaaa cctaaagtct tggcatgaag aaattgtcca tgtcctttca aagtcttgcg
     9901 aggaccatag acctcatcac cagcgactgg atggccgata taagccatgt ggacacggat
     9961 ttgatgagtg cgccctgtct ccagttgcaa ctctactaag ctataatcgc caaagcgttc
    10021 caagacgtga aaacgcgtca ctgcaggctt ccctttagca gttacagcct gtttcttacg
    10081 gtctttttca ctccggccaa tcggcgcttc aattacacca cgatcattag gtagatttcc
    10141 atgaacaatc gcccaatatt tgcggagaga ctttttatcc ttgagttctt gggcaagtgc
    10201 tagatgcgca tcatcgtttt tagcaatcat gagaagacct gacgtatcct tatcaatacg
    10261 gtgaacaatc cctggacgca gaaccccatt gatacccgac aagtccttaa tatgatacat
    10321 gagggcattt actagggttc cactggtatg accagcactc gggtgcacaa ccattccctg
    10381 aggtttgtta acgacagcca catcctcatc ttggtagact atttctagcg gaagatcctc
    10441 agccacatac tctaatacct ctggttctgg cacatggtaa gtgacgacat caccctcttg
    10501 gactgtgtat ttagctttct tgacttgacc attgaccaag acctggcctg atttaatttg
    10561 ttcattcgcg agactacgtg ataattctga caaatctgac aaagccttat ccaaacgcag
    10621 accaccagtt tcaattttaa tttccattta tttcctcttt tagcattgca atcaataaaa
    10681 taatcactcc aaccgtcaga tagctatctg ccacattgaa aattgcaaag ttgataaagt
    10741 caaggtggaa catatccaca acaaagccct gactgaccct gtcaataaag tttccaagac
    10801 cacccgcgat tattagagtc aaacccaaga ccatccagaa tgagtcctcc atgtgtttat
    10861 gtaaatacca aatggcacct atcacgacaa ccagagtaat gacagcgaat aacaactgct
    10921 gatcttgtaa gatagaaaag gctgcacctc gattttgcag gtaggtcaag ctaacgaaat
    10981 tggggatcca ggagcgcact tcacccagtg gaatctgctg gacgatatag gatttgacca
    11041 actgatccag cccaatcaaa agcagtacaa tgactgccac tattgctctt tttttcatga
    11101 tttcctcttt tgatcaaaat attcttgcat gacttctacg aagagagtcc cagcttgact
    11161 aagctccact tcttcacgtt taacatagac catgcggtta tctaggttat ccttgagacg
    11221 aataactgta atgccattaa cactgtcact atctaaaaat ccagaacctg tcgcataggc
    11281 gtccgtccgc tccaaaatac cattcaaggt ggcacggtct gtcacattaa acatctgtga
    11341 gctagcgctg gtatcaacaa agttctctga ataataaagg tactcgtctt tctcttgagt
    11401 gaaacgaacc gttggtaaat ccgctaaatc ctccatgact aattcctctt tctgggctaa
    11461 aggatgaccc tcacagagat aaatatgggt atggaaagga atcaattcga tgacctccag
    11521 acctaacttt tcaacccgtt gcataatccc ctttttattt tgattgttga ggtagataat
    11581 cccaatctca ctatgccctt gcgccacttc atctaatatt tgaacagtag ttgattcaaa
    11641 aatacggaag ttcttatagt caggatagcg ctctgaaaag gccgtaatag ttggtggtaa
    11701 gaagtcatag tgctggctag caacggaaaa ttcatctttt tcttcttcag gattggcata
    11761 ctgattttga aaaatatcaa atcctttaac caattcttgc gctttttcat aaaattccat
    11821 cccacgacgg gtcaagaaag tccctgagct ggtccgacgg aaaatcttaa aacccaactc
    11881 tttttccaaa tcccgaacag aaatagacag actcggctga ctaacataca tcttttcagc
    11941 agcttcacga aaagtaccac tattggcaat agccacaaca tagcgtaatt gttgaatgtt
    12001 catcttctac ccctaacttc tttatctttt cattatacca tattttagaa gttttccaaa
    12061 aaggaaaaaa gaacatccta ttcttcttaa ctatcttcac tatctgcctt tctcaagcca
    12121 accttatttt caaaatcaat tcaaaaaaat aactggctac acaccactac aatatcgaaa
    12181 agaaaaacgt tgactatttg tgaaaaaaga aaatgccgga aagttccgac attattttag
    12241 taagctaact tcctgaaaat aggagcaacc acacatccca gaaggcagtg atattaatga
    12301 gaatatgaac tagtattgga tagtagagat ttttagtcat gcgatacaat agagctaaaa
    12361 taagacctcc actagcataa atgaaaaaag caagaggagt taaagcaaaa ttgatatgaa
    12421 tataaccgaa aataatagca gaaagcaaaa catctccgta ccaaggcgag tttttgaaaa
    12481 aggttgtcat aatcacaccg cgataaatca attcctcagc aataggggcg atgaagcaaa
    12541 cgatgagcaa gaaataaggg aactcctgtc tccccatcat ttctaccgtt tcattcaaag
    12601 aaatctgatt tgaagacagg gatatgaaat acgaaaagag gaagtcagac atatatgaaa
    12661 tgatgtagcc cagtaaaagg tagatgaagt acctcagctg ccacttgaaa tgaaaaattt
    12721 tctttcctgc aaaaaccagt agatagatga ccgctaagaa aagaactccg ctctccatca
    12781 aaagcagaat ctgaaaaaat tcacgacttg ctggtagata gggctttgcg aggtgattga
    12841 aaactctcca aaaccaagtt gatttgtaaa aaattaagga caatgctagt aaaatttgaa
    12901 tagcccgttt tttcatatta aattctctgc tttctccact tgtttcttca tattactaat
    12961 aaattttact taaaatctcg cagcacttcc tttgcaaaga tgattgcctc ctccaatata
    13021 tcctaaatca taggtgcctc tgggacaaaa tccatgaacc ggcagagtta atactggttc
    13081 tatttcccaa tcgtacctac cattaggatt tttaccatat gaatctgctc caccttgtat
    13141 cagctctaat tcttcatttg ttagatttat attttttgtc attaaaatca tgatatattt
    13201 cctccattat tcttcagatt agttgagtaa tctgatactc atacctactt acaaaaaaac
    13261 tattatatta agttggtttt ttaatttgtc tagttgcaac attgacaaac atagtatagc
    13321 atatctttgc gaaatatcct cttcaaatca tgaattgtca tcaaaacatc ttaaactata
    13381 aaatcaatta gtctcaagct ttctatcaat ttcttctcca aaatatgcta taataatagc
    13441 aaaagataaa gaaggaagac ctatgattaa actactagcc ttggatatgg atggaaccct
    13501 cctcaatgaa gccaaggaaa tcccacaggc tcacatcgct gctattcacc aagccattga
    13561 aaaaggtgtc aaactggtcc tctgtacggg tcgccccctt ttcggtgtcc tcccctacta
    13621 caaaaaactg ggactcgacc tccagaacga atatgtgatt gttaacaacg gttgttcaac
    13681 tcaccagact agcgactggg gcttggttga ctggcaagaa ctgagtccag ctgacatcga
    13741 atacctctat gaccttgctg aaaagagtga tgttcagttg acactttttg acgagtcaca
    13801 ttattttgtt ctcggtggca agcccaatca agttattgaa aatgatgcta aactagtatt
    13861 ttcagacctg actgaaattt ctcttgagga agcgactagt ggaaagttcc ggatgttcca
    13921 aggtatgttt ttaggaacaa aagaacaaac agacgatttt gagcagcgtt ttgctgaaga
    13981 gctttgccaa cgattcagtg gagttcgttc gcagcctgtc atttatgaag caatgccact
    14041 tggaacgaca aaggctactg ctctttcacg actagctgag attttgaaga ttgattcctc
    14101 agagattatg gccatgggcg atgctaataa cgatatcgaa atgctccagt ttgcagggct
    14161 tgggattgca atgggaaatg ccagcgatta tgtcaaatct cttgcggatg ccgttacctc
    14221 aagcaacgaa gaagacggcg ttgcgcgtgc tattgagaaa tatattctat aaaaaagaaa
    14281 agcaaataga cagaagttac tgctatttgc ttttttgcta atattttaaa atacggacta
    14341 atcaatagac aagaatagcg aatcataaaa atcgatttac tagatgccat agtatcttat
    14401 agttgctaat aagaagttag tctagcagaa tgaatctctc atttctccca cactaatctg
    14461 taatttgtct atacatttct ggtcttctat ctcgaaacaa gccccagttt aggcgttcac
    14521 tcgctccctt gtctaggtca taagtagcta acagaacagc ttcttcttgt ctttcagctc
    14581 gttctagaat agctcctgtt tcatccgtca taaaggagga accgtagaag tcaagactgg
    14641 aactctgtcc gccattttcc tcactaggag taacctcctc taaaccataa cgattggctg
    14701 cgatgactgg aacaatattc gctgctgcgt gcccttgcat agtacgttgc cagtgaccac
    14761 aactatctgt atccaaaatc ggctctgaac cgatggctgt tggataaaag agcaattcag
    14821 caccattcaa tgcaagacag cgcgctgttt cagggaacca ttgatcccaa cagataccga
    14881 taccaatctt agcatagcga gtattccaga ccttgaaacc agtgttacca ggcgtgaaat
    14941 agaatttttc ttgataataa tggtcatctg gtatgtgggt ctttcgataa acgcccagca
    15001 cttccccatc tgcatcaatg acggcaatag agttatacaa gacattacca tctttttcat
    15061 agaaactgat tggtaaaaca acttgtagtt ccttagcaag caccttaaaa tgctgaatgg
    15121 cagtattttc cgctacagat tgggcatact ggtagtagtc atactgacgt tcctgacaga
    15181 aatagggatg ttcaaacaac tcgggcaaga gaataatttg ggctccttgc tcagcagcct
    15241 gacgtactaa acgctctgcg gtttggatat ttgttgccac atccttagcg cattgcatct
    15301 gaatggttgc aactcttaca tttctcatct ttttctccta ttctggaatt tgttgggtga
    15361 tacagtggat attgccacca cctaagagaa tatctctggc tggtattccg acaactttac
    15421 ggtctgggaa acacttgctg aggatatcta aggccacttg gtcgtttaca tcctcaaact
    15481 gtggaaccaa gacagccttg ttggcgatat aaaagtttac gtaggaagct gctagtcgtt
    15541 cacctgcgta tcgcttttct tctccttctt catagatgta gcctggcaaa tcttcttctg
    15601 tcacaacttg tcgaactgca gggataggca atttatgaat ggtgaagtga caaccttttg
    15661 catctgtttc ctgttctaag agttcgagat ctgcttttga catggcatac tggggatcat
    15721 tttcgtcatc tgtccaagcc aaaacaagct cagcaggacc aacaaaggca gcaacattat
    15781 cgacgtgttc attggtttca tcctgataaa taccataagg aagccaaata actttttcag
    15841 caccaagact ttctaataat gtgttttcaa tctcctcttt agtcaggtta ggattgcgac
    15901 caggactaag caagcaactt tcagttacga gaatagttcc ttgaccatcg ctatggattg
    15961 cgcctccttc cagtacaaaa ggtttagcat catagacagg cctttccaag gcctcagcaa
    16021 aacgactggc tacttggtca tcctcttcat aatcttgata aagaccatca taggtgcctc
    16081 cccaagcatt aaaggcccaa tccacggcta atttcttacc tttatcattg acgagaatgg
    16141 ttgggccagt atcacgcgcc caggcatcat tggtgggaat gtctaaataa acaaccttgt
    16201 ctccaagata ggattgggct tcagatagat aggcctgctc caccaaaaga tagactcttt
    16261 ccccttctgc tatggtctcg atgatctgag taaatgctct tttagcagcc tttccttgaa
    16321 aaggccatga tcctggtcga gtcggccata tcatgagggt accatgatgg ggttcgtact
    16381 ctgctggcat gtgatagcct aatttttttg gactgtccat catgataatc tccctttaaa
    16441 gtcttgatag ccaaaagctt tgagtaagct acagtctccc tgttcgtcca tgagatagag
    16501 acttggcaat ccaataccat taaaggtatt atttttgaca aaagaataaa tggccatgtc
    16561 ttgaaaataa agtctgtctc cgatttggac tggattttca aaactataat caccaatcac
    16621 atcgcccgtc agacaggtat tagaagaaag tctgtaggta tgggcttttt cctgtgactc
    16681 aaagccattt ctcaaaggtg gacgataggg catctcaagt acatcaggca tatggcaggt
    16741 cgcagaggcg tctaaaacca agatttccat accgttttct acaatatcta atacctcagt
    16801 tgctaaataa cccgcattaa gcgcaatggc ttcaccaggc tcgatataga tttcaagatt
    16861 gtaagttttt cggatacgct tgatttctga aatcagcaaa tccacatcgt aaccttctct
    16921 tgtaatatga tgaccaccac ccatattgag ccattttacc tcatgtaagt agggaccaaa
    16981 ctgttcttct actgctttca aagttgtttg taaatcatct gctccctgct cgcaaagggt
    17041 atgaaaatga agtccgtcaa ccaaatctag caaatcactc ggaatcttgt ctatagtaac
    17101 tccaaagcga gaacctggtg cacaagggtc atagagcgcg tgatctcctt gagttgaaca
    17161 ctgagggttg aggcgcaaac caacactgac accagcctct cgacaacgcg gaccgtgttt
    17221 acgcaactgt ctctctgagt taaagacgat atggtccatt atctctagca attcctccaa
    17281 gtctgcatcc ttgaaagcag gcgcaaatac atggacttca ccaggaaatt cttcccttgc
    17341 caatttggcc tcatagagtc cactagctgt cgtacctgat agatactggc taatcaaggg
    17401 ataagttttg tagagggaat atgccttctg ggcaagcaag accttgcaac cggcctcttc
    17461 ttgtacatat tgtagaatgc ggcaattagc ttctaacttg gccaagtcaa taacataggc
    17521 tggtgttggt acttgttcta acttcattag tccaccattt gtggattttc aaccacaacc
    17581 catggcaaac catactcatt caaagcttcc atgaatggat ctggatctaa ctcctcaagg
    17641 ttatacactc cagcttgttt ccaagttccg ttcatgacta attttgtccc aatcatggct
    17701 ggaactcctg tcgtataaga aatagcttgc gaaccaacct ctgcgtaaca ttcctgatgg
    17761 tcgcagacat tgtagatata gatagtcttt ttgacaccgt ctttgacacc tgtaaagata
    17821 catccaatat tggtttttcc gactgtacgt ggcccaagac tggcaggatc tggaagcaag
    17881 gctttcaaaa attgaattgg aacaatttct tggccgttaa agttaatggt atccgtacga
    17941 aggagtccaa cattttcaag acatttcatg tgcgtcaagt aagattgacc aaaagtcata
    18001 aagaaacgaa tgcgtttgac acctggaatg ttcttggcca atgattcgat ttcttcatgg
    18061 tgaaggagat acatatcttt ttgtccaact tgagggaaat catactcacg cttgatagac
    18121 atagcttcga cttcgaccca tttcccatct tcccagtaag aacctggcgc agaaacctca
    18181 cggagattaa tttctggatt aaagttggtt gcaaatggat aaccgtggtc accgccatta
    18241 cagtctaaaa tgtcgatata atggatttca tcaaaatagt gtttgagggc ataagctgaa
    18301 aagacactag ttacacctgg gtcaaaacca gaaccaagaa gagcagtcaa gcctgcttct
    18361 ttgaatttct cttgataagc ccactgccat gagtagtcaa agtaggctgt aaaaccaagt
    18421 tccttacaac gtttttcgta gatagcacgc cactcagggt cttctgtgtc ttctgcttcg
    18481 tagttggctg tatcgatata gtgaacacct gttgccaaac aagcatccat aatggttaaa
    18541 tcttgataag gcagagctac attcaaaaca gcttctggtt tgtagctttc aatcagggca
    18601 atcacttctt caaccttgtc agcatcaagt gctgcagttt caattttagt acttgttttg
    18661 ccttctagct tcgctttcaa gtcatcgcat tttgacttgg tacggctagc aatcataatc
    18721 tctgtaaatg tttcgctatc ttgacaaatc tttgaaatag caacttgggc aacgccccca
    18781 caaccaataa ctagtaaacg actcattttt ttccttcctc ttcttctaaa atgtcctcaa
    18841 catacttggg caacataaag gctcccacgt gtaagtttgc agtgtagtat tctgtgaaaa
    18901 gctggcgttt tttccagcct tccttgtcaa aatctttgac agggtggtat tttttcgatg
    18961 caaatccaaa caaccaatag ccagctgggc tagttggaat atgggcctga taaacccgac
    19021 tgattggaaa ggcttgattg accttgcggt gcatgcttcg gcaggccgac tcatcctcgt
    19081 caaagaaggg actcccatgc tggtaaatca tgatgccgtc ttccttcaga gctcgataac
    19141 tattgccgta gaattccttg gtaaagagtc cttccgtatg gccaaatgga tctgtcgcat
    19201 cgttgatgat aatatcgtaa tcatcttcgc agtttcgcaa aaagcgtagc ccattttggt
    19261 agtaaatggt aacacgagga tcatctagcc ctgcagcaaa gtctgggaaa tactcacgac
    19321 agacctcgac caacatctca tccggttcca caatatcaat ttgctccagt tcaggataga
    19381 gggttaatac ttgggcaaca ccgccgtcac cacccccaat aaccaatact ttctttggat
    19441 ttgggtggac agccatggga acgtgaacgg tcatttcatt gtagacgaaa tcatccgcat
    19501 ctgagaacaa gacatggcca tttaaaatca gtattttccc aaaagctggc gtatccaaga
    19561 cttcgatatc ctgccattca ctttttccag cgtaaagttg cttggctgtt ctcagagaca
    19621 atttgacatc tggagtatga acttcagaaa accataaatc catctatttc tccttatatt
    19681 atatttagcg cagttagcta ctgccaaagc ccaagtggta tacttggaat aagccactgt
    19741 ggattagttc atttcctcca atcgcttgac gatttccgaa aggctctaac cacagctttt
    19801 gtttcaattg gtaatgagtt tgataacgca tagacgtttt atctcgtcta aggtaacaag
    19861 gcaaaaagtt cgtggataac caagtagact tgaaatacta catctggagg tactcccatg
    19921 ctttatgtgg gcattgatat cgctaaaaat aaacacgatg ttacagcctt gaatgttcaa
    19981 ggaaaaactg ttcttaaacc actcactttt tcaaataata aagctggttt tgaactctta
    20041 gatctgtctc ttcgacagct caaccaagac tgtctcatcg ctcttgaaga tactggacat
    20101 tatgccttta atctactgaa cttcctgcat gaacaaggat ataaagttta cacctacaat
    20161 cctttgctca tcaaggaatt tgccaaatca ttatcacttc gcaagactaa aacggataag
    20221 aaagacgctc atggcatcgc tcttaaactt ctttctgacc ccaatcgtga acaatttcaa
    20281 cacgataatc ggcaagtaga actaaaaata ctggctagac atattcatcg tctcaagaaa
    20341 aacagtctga ttggaaagta caatacactc gttgtcttga tatcatcttt cctgagttgg
    20401 ataaaatcgt tggaaagcat tcagaatata cctaccaact cttgacacgc taccctaatc
    20461 ctcagaaaag gattgaggca ggatttgata agctgataga aattaagcga ttgaccgctt
    20521 ctaattcaag ggctttttgc cgtgctctaa aatcatcgcc aaatcatcaa attgaaataa
    20581 gaaatagttt agataaaact attgactttt cttatagttt gtctttctct taataacgtt
    20641 gatatgattg acctctggat cttccgtccc ttggagggag caaccacgtt ccttggcgaa
    20701 ttggatatag tctacaattt ctcgtgtaat gcgttcacca ggagccaaga taggaatccc
    20761 tggaggatag cacatgacaa attctccaca gacctgtcca acagactcat ctaaggtcaa
    20821 actttttctc tctgaataga aggcttcttg tggagacagc accaactcgg gctgaatata
    20881 ttctccagct attaagtcct tcccatctcg tgaatagagt ctcttaatat cagccagagc
    20941 accaaccaag cgctcgatgt cttggatgcg gtcgccgatg gaaatatagg ccaagatatt
    21001 gccgatatca ccaaactcga tctgaatgtc gtattcgtct cgcaagaggt cataaacctc
    21061 gatacctgtt aagcctattc cctgagtgta aactgacaac ttggttacat caaaatcaca
    21121 gaccgacaca ccatctatta actcttttga gtaagcatag taaccgccaa tggcattgat
    21181 ttcatgacga gcgtactcgg atagctcaat gacttcctca aacgactctt taccacgaag
    21241 ggccaagttg cgacgtgaaa tatccaaact agccatcaat aagtaagagg cagatgtaga
    21301 ctgggtcagg tttataatct gacgaacgta ctcgggattc atctgctccc cgattaaaag
    21361 aagcgaactt tgtgtcaaac tcccaccaga cttatgcatg gaaactgctg ccatatcagc
    21421 tcctgcatcc atagcagaaa ttggaagttt accagtgaaa tgcaaatgcg ctccatgggc
    21481 ttcatctact aaaaccatca tgccagcttc atgagccatt tctgtcaacc cctttaggtc
    21541 tgaacagatg ccgtagtaag taggattgtt gattaggata gccttagcat ctggatggtc
    21601 ctttatggcc tgtgctactc ggtcattttc aagacctaaa gcgataccaa tcttaggatc
    21661 tacactcatc tcgatataga tgggaatggc accacataga accaacgcat tgatagcaga
    21721 tttatggaca tttcgtggca gaataatctt atctcctgcc ttgcaggttg ccagaatcat
    21781 agtctgcacc gatgaagttg ttccaccaat cattagaaag gcatggctag ctccaaaagc
    21841 atctgcagcc agctcctctg catcacgaat aatcgaaata ggatggccta aattatccaa
    21901 gggtttcatc gaattgacat caatgcctac acatttttct cctaagagtt cgacaagttc
    21961 tggatttccc cgtccacgct tgtgacctgg aacatcaaag ggaacaatcc ttttcttgcg
    22021 taacttcacc aaggcttcat aaattggggc ttggttttga tctaactctt tcaaaacata
    22081 ctcctttcaa tatttttagg accttatgaa aactaaggaa ctaaaggttg actcatgaaa
    22141 aaagagcagg ttttcacctg ctctgcaatc ttctgacgtg tttattttgg tttctgttga
    22201 gtatgtctgt tcccgatgtt tcctaactct ctagtagcaa atattacgta ctttattgat
    22261 cgtttcacaa gatgacgtgt gctttcacca cactaaaaat ttatgaatta ggacaagtgt
    22321 cctaacatca acttataaaa gtaggctttt aaccctatca ataatgtggc ttttcaacca
    22381 cgcttcggca ttcaaccctg cctgtccgta ggcatttttt actcgggttt atatttgcta
    22441 gaaaacatca tctcattttc taagctttat tactatatca tgtttttaag aacttgtaaa
    22501 gtattttttg ataaaaaaca aaaatatagt agattgaaac tagaatagta cacttctgct
    22561 tctaaaacat tattagaaat agattttact gtcctgatcg atttgttctg ttcttgtttc
    22621 attttactat atgttcgtaa atgaaagttc tataatgaag ttagccaccc agccctccta
    22681 aaaattagat ggttcaacta gctgatagct cttgtaggca taagaaaaca cctctgtgtt
    22741 atacttgttg ttcaaccaca aacacaagaa aggcacagag atgcaagaca attatactac
    22801 aaaagccaaa catttgacaa tcgatagccg tcgcttaatc gaaagatgga aaaaagaagg
    22861 gaaatcaaat agagaaattg cctctctgct tggaaaagtt cctcaaacta tccacactga
    22921 aatcaagcgt gggacagtcc gacaatgtct tggaaaaggg cgcttcaaag aggtttattc
    22981 tgccgactat gctcaacagt cttatgaaaa caatcgcaag cgctcggtca ggaaatcaag
    23041 cgtgaccaag gaactaaagg aaaagattct ccactatcat aaccaaaaat tttcgcctga
    23101 aatgatggtg atgg
//
LOCUS       DBMVGT010000025        22499 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.025, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000025 DBMVGT010000000
VERSION     DBMVGT010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 22499)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22499)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22499
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.025"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            16..86
                     /locus_tag="AC0DU4_001103"
     tRNA            16..86
                     /locus_tag="AC0DU4_001103"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:48..50,aa:Gly,seq:tcc)
     gene            122..195
                     /locus_tag="AC0DU4_001104"
     tRNA            122..195
                     /locus_tag="AC0DU4_001104"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:156..158,aa:Ile,seq:gat)
     gene            202..289
                     /locus_tag="AC0DU4_001105"
     tRNA            202..289
                     /locus_tag="AC0DU4_001105"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:236..238,aa:Ser,seq:gct)
     gene            complement(415..1350)
                     /gene="birA"
                     /locus_tag="AC0DU4_001106"
     CDS             complement(415..1350)
                     /gene="birA"
                     /locus_tag="AC0DU4_001106"
                     /EC_number="6.3.4.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional biotin--[acetyl-CoA-carboxylase]
                     ligase/biotin operon repressor BirA"
                     /protein_id="HIN4237073.1"
                     /translation="MKSYQAVYQILSKETDYISGEKIAEKLSLSRTSIWKAIKRLEQE
                     GIEINSIKNRGYKLMNGDLILPEILEENLPIKVSFKPETKSTQLDAKEAIDLGHEANT
                     LYLASYQTAGRGRFQRSFYSPQGGIYMTLHLKPNLPYDKLPSYTLLVAGAVYKAIKNL
                     TLIDVDIKWVNDIYLNNHKIGGILTEAMTSVETGLVTDIIIGVGINFTIKDFPQELKE
                     KAASLFKATAPITRNELIIEIWRAFFETPAEELLYLYKKQSFILGKEVTFTLEQKDYK
                     GLAKDISENGKLLVQCDNGKEIWLNSGEISLNSWK"
     gene            complement(1347..2207)
                     /locus_tag="AC0DU4_001107"
     CDS             complement(1347..2207)
                     /locus_tag="AC0DU4_001107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000959966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HIN4237074.1"
                     /translation="MLVFSEYQTGTIDLALSFYGYEECTPNYSFGPAIRDTYVLHYIS
                     KGQGKFHYKGKIVDLKEGDFFLLKPEELTFYQADSKEPWAYYWLGITGGKSPDYFALS
                     QISDQSYLIQSETCHTQTTAKLISDIVRFAQITKSSELAQLHIMGQLHELMFHLGTIA
                     PNQKKKNISSTHQLYLECKRLIDSHYPQSLTIQDLAKELSVHRSYLSSVFKEFNTLSP
                     KEYLLYVRMHRARQLLENTQESIKVIAYSVGFSDPLHFSKAYKQYFNQSPSHTRKEYS
                     QYQLVRKATL"
     gene            2315..4477
                     /locus_tag="AC0DU4_001108"
     CDS             2315..4477
                     /locus_tag="AC0DU4_001108"
                     /EC_number="3.2.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000538915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_function: GO:0004557 - alpha-galactosidase activity
                     [Evidence IEA];
                     GO_process: GO:0016052 - carbohydrate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="HIN4237075.1"
                     /translation="MGVRIENNLFYVESKNLSLIIENRNGYLLLKHLGKTIKNYKGSN
                     SVYERDHAFSGNPTATNRTFSLDTQRQIFGQHGLGDFRKPTIQVQHSVTEVTDFRFVE
                     AKILKGQNGPQGLPSPHSMDDTETLVLMLEDSKAQLSLTLYYTTFNNDATIASYSKLD
                     NNSNQEVVIHKDFSFMADFPAADYEIVTLQGAYAREKTVRRQQVEQGIFSISSNRGAS
                     GHAQTPALLLCEQGVTEDAGNVFAIQLMYSGNFEAFVQKNQLNEVRVAIGINPENFSW
                     KLAPEEYFETPVALVTHSDQGLTGISHESQNFVLKHITLSEFSKKERPILINNWEATY
                     FDFQREKLLELADEAKKVGIELFVLDDGWFGNRFDDNRALGDWVVNEEKLGGSLESLI
                     SAIHERGLQFGLWLEPEMISVDSDLYRQHPDWAIQVPDYEHTYSRNQLVLNLANPQVV
                     EYLKSVLDQLLSYHEIDYIKWDMNRNITKLGNGLTYLETQMQSHQYMLGLYELVSYLT
                     EKHSHILFESCSGGGGRNDLGMIRYFPQVWASDNTDAIARLPIQYGSSYLYPTISMGA
                     HVSAVPNHQMGRMTPLETRGHVAMMGNLGYELDLTNLSDEEKATIANQVNLYKELRPV
                     VQLGQQYRLINPDTASNEAAVQFNYGNQTIVTYVRVLSVVETMETTLKLKDLDEEGLY
                     KLQENGEVYSGAELMYAGLTVILSQGDFLSRQYIFRKL"
     gene            4569..5828
                     /locus_tag="AC0DU4_001109"
     CDS             4569..5828
                     /locus_tag="AC0DU4_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HIN4237076.1"
                     /translation="MEWYKKIGLLATTGLALFGLGACSNYGKSADGTVTIEYFNQKKE
                     MTKTLEEITRDFEKENPKIKVKVVNVPNAGEVLKTRVLAGDVPDVVNIYPQSIELQEW
                     AKAGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFEELGLKV
                     PETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQ
                     PNAIKLSDPIMKDDIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAI
                     TAINEQKPNFKIGTFMIPGKEKGQSLTVGAGDLAWSISATTKHPKEANAFVEYMTRPE
                     VMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEADFHTLTM
                     NYVLTGDKQGMVNDLNAFFNPMKADVD"
     gene            5842..6708
                     /locus_tag="AC0DU4_001110"
     CDS             5842..6708
                     /locus_tag="AC0DU4_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4237077.1"
                     /translation="MKKVLQKYWAWAFVVIPLLLQAIFFYVPMFQGAFYSFTNWTGLT
                     YNYKFVGLNNFKLLFMDPKFMNAIGFTAIITIAMVVGEIALGIFIARVLNSKIKGQTF
                     FRAWFFFPAVLSGLTVALIFKQVFNYGLPAIGNALHIEFLQTSLLGTKWGAIFAAAFV
                     LLWQGVAMPIIIFLAGLQSIPTEITEAARIDGATSKQVFWNIELPYLLPSVSMVFILA
                     LKGGLTAFDQVFAMTGGGPNNATTSLGLLVYNYAFKNNQFGYANAIAVILFLLIVVIS
                     IIQLRVSKKFEI"
     gene            6722..7555
                     /locus_tag="AC0DU4_001111"
     CDS             6722..7555
                     /locus_tag="AC0DU4_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4237078.1"
                     /translation="MKQDERKALIGKYILLILGSVLILVPLLATLFSSFKPTKDIVDN
                     FFGFPTNFTWDNFSRLLADGIGGYYWNSVVITVLSLLAVMIFIPMAAYSIARNMSKRK
                     AFTIMYTLLILGIFVPFQVIMIPITVMMSKLGLANTFGLILLYLTYAIPQTLFLYVGY
                     IKISIPESLDEAAEIDGANQFTTYFRIIFPMMKPMHATTMIINALWFWNDFMLPLLVL
                     NRDSKMWTLPLFQYNYAGQYFNDYGPSFASYVVGIISITIVYLFFQRHIISGMSNGAV
                     K"
     gene            7855..9297
                     /gene="gtfA"
                     /locus_tag="AC0DU4_001112"
     CDS             7855..9297
                     /gene="gtfA"
                     /locus_tag="AC0DU4_001112"
                     /EC_number="2.4.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004645 - 1,4-alpha-oligoglucan
                     phosphorylase activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose phosphorylase"
                     /protein_id="HIN4237079.1"
                     /translation="MPIQNKTMLITYSDSLGNNLKDLYDNLEEHFGDAIGGVHLLPFF
                     PSTGDRGFAPVDYDEVDSAFGDWEDVKRLGEKYYLMFDFMINHISRQSKYYKDYQEKH
                     EASEFKALFLNWDKFWPENRPTQSDVDLIYKRKDRAPKQEIVFEDGSVEHLWNTFGEE
                     QIDLDVTKEVTMEFIRKTIQHLASNGCDLIRLDAFAYAVKKLDTNDFFVEPDIWDLLD
                     KVRDIAAEYGTELLPEIHEHYSIQFKIADHDYYVYDFALPMVTLYTLYSSRTERLAKW
                     LKMSPMKQFTMLDTHDGIGVVDVKDILTDEEIDYASNELYKVGANVKRKYSSAEYNNL
                     DIYQINSTYYSALGDDDVKYFLARLIQAFAPGIPQVYYVGLLAGKNDLKLLEETKEGR
                     NINRHYYSNEEIAKEVQRPVVKALLNLFSFRNRSEAFDLEGTTEIETPTAHSIVIKRQ
                     NKDKSVTAVVEIDLQNQTYRVIENGVEVSF"
     gene            9435..10628
                     /locus_tag="AC0DU4_001113"
     CDS             9435..10628
                     /locus_tag="AC0DU4_001113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008293041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0008754 - O-antigen ligase activity
                     [Evidence IEA];
                     GO_function: GO:0008755 - O antigen polymerase activity
                     [Evidence IEA];
                     GO_process: GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen ligase family protein"
                     /protein_id="HIN4237080.1"
                     /translation="MKSIGFIEKLKGLSSKELILLGIILSIFLPFYLFVVVLCLYIIS
                     LIFTGDMKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQS
                     ILSHKFFRLILQFVLFGSVLSAAFASLEHFQIVKKFNYAFLSPNMQVWHQNRAEVTFF
                     NPNYYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRTAFPAIIAG
                     AIIYLFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMAL
                     FKQNPFWGEGPLTYMHSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRL
                     MMDMSQESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQSGFIFLLVMCSIPLEHRMLV
                     SDMTD"
     gene            11314..13293
                     /locus_tag="AC0DU4_001114"
     CDS             11314..13293
                     /locus_tag="AC0DU4_001114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000742236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4237081.1"
                     /translation="MKKNRVFATAGLVLLAAGVLAACSSSKSSDSSAPKAYGYVYTAD
                     PETLDYLISSKNSTTVVTSNGIDGLFTNDNYGNLAPAVAEDWEVSKDGLTYTYKIRKG
                     VKWFTSDGEEYAEVTAKDFVNGLKHAADKKSEAMYLAENSVKGLADYLSGTSTDFSTV
                     GVKAVDDYTLQYTLNQPEPFWNSKLTYSIFWPLNEEFETSKGSDFAKPTDPTSLLYNG
                     PFLLKGLTAKSSVEFVKNEQYWDKENVHLDTINLAYYDGSDQESLERNFTSGAYSYAR
                     LYPTSSNYSKVAEEYKDNIYYTQSGSGIAGLGVNIDRQSYNYTSKTTDSEKVATKKAL
                     LNKDFRQALNFALDRSAYSAQINGKDGAALAVRNLFVKPDFVSAGEKTFGDLVAAQLP
                     AYGDEWKGVNLADGQDGLFNADKAKAEFAKAKKALEADGVQFPIHLDVPVDQASKNYI
                     SRIQSFKQSVETVLGVENVVVDIQQMTSDEFLNITYYAANASSEDWDVSGGVSWGPDY
                     QDPSTYLDILKTTSSETTKTYLGFDNPNSPSVVQVGLKEYDKLVDEAAKETSDLNVRY
                     EKYAAAQAWLTDSSLFIPAMASSGAAPVLSRIVPFTGASAQTGSKGSDVYFKYLKLQD
                     KAVTKEEYEKAREKWLKEKAESNEKAQKELASHVK"
     gene            13360..14856
                     /locus_tag="AC0DU4_001115"
     CDS             13360..14856
                     /locus_tag="AC0DU4_001115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237082.1"
                     /translation="MKKYIFMRVLRSLVSIFLVTTLTYTIIYTLVPRKLIFKQDPNYN
                     KIATTADKRDNYENTVFERMGYIEYYDTKELQEKASSMDSSVTVEANATNKAIYEKYI
                     NQLGHGWTLGEFTESGQFYATREIPIFERVFHFYANLIDIDHTNKIQDPENPDLKRYL
                     RFENDPAIGWSLVGSGTKHKYLLYFNSQFPFVHQNFVNLNLGDSYPTYANTPVLQVIT
                     QGQGQTKTAQVQFPTGKKTSSVNIYSRTYKSPSQADSREVASYGKDDPYTATESNYQY
                     PSMIVSSAITGLIGLVLAYALAVPLGSAMARFKNTWIDSLSTGALTFLLALPTIALVY
                     IVRLIGSSISLPDSFPILGAGDWRSYVLPAVILGLLGAPGTAIWIRRYMIDLQSQDFV
                     RFARAKGLSEKEISNKHIFKNAMVPLVSGIPGAIIGVIGGATLTETVFAFPGMGKMLI
                     DSVKASNNSMVVGLVFIFTCISIFSRLLGDIWMTIIDPRIKLTEKGGK"
     gene            14856..15782
                     /gene="oppC"
                     /locus_tag="AC0DU4_001116"
     CDS             14856..15782
                     /gene="oppC"
                     /locus_tag="AC0DU4_001116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="oligopeptide ABC transporter permease OppC"
                     /protein_id="HIN4237083.1"
                     /translation="MSTIDKEKFQFVKRDDFASETIDAPAYSYWKSVFKQFMKKKSTV
                     VMLGILVAIILISFIYPMFSKFDFNDVSKVNDFSVRYIKPNAEHWFGTDSNGKSLFDG
                     VWFGARNSILISVIATVINLVIGVFVGGIWGISKSVDRVMMEVYNVISNIPPLLIVIV
                     LTYSIGAGFWNLIFAMSVTTWIGIAFMIRVQILRYRDLEYNLASRTLGTPTLKIVAKN
                     IMPQLVSVIVTTMTQMLPSFISYEAFLSFFGLGLPITVPSLGRLISDYSQNVTTNAYL
                     FWIPLTTLVLVSLSLFVVGQNLADASDPRTHR"
     gene            15791..16858
                     /locus_tag="AC0DU4_001117"
     CDS             15791..16858
                     /locus_tag="AC0DU4_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237084.1"
                     /translation="MTKEKNVILTARDIVVEFDVRDKVLTAIRGVSLELVEGEVLALV
                     GESGSGKSVLTKTFTGMLEENGRIAQGSIDYRGQDLTALSSHKDWEQIRGAKIATIFQ
                     DPMTSLDPIKTIGSQITEVIVKHQGKTAKEAKELAIDYMNKVGIPDADRRFNEYPFQY
                     SGGMRQRIVIAIALACRPDVLICDEPTTALDVTIQAQIIDLLKSLQNEYHFTTIFITH
                     DLGVVASIADKVAVMYAGEIVEYGTVEEVFYDPRHPYTWSLLSSLPQLADDKGDLYSI
                     PGTPPSLYTDLKGDAFALRSDYAMQIDFEQKAPQFSVSETHWAKTWLLHEDAPKVEKP
                     AVIANLHDKIREKMGFAHLAD"
     gene            16869..17795
                     /locus_tag="AC0DU4_001118"
     CDS             16869..17795
                     /locus_tag="AC0DU4_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4237085.1"
                     /translation="MSEKLVEIKDLEISFGEGSKKFVAVKNANFFINKGETFSLVGES
                     GSGKTTIGRAIIGLNDTSNGDIIFDGQKINGKKSREQAAELIRRIQMIFQDPAASLNE
                     RATVDYIISEGLYNHRLFKDEEERKEKVQNIIREVGLLAEHLTRYPHEFSGGQRQRIG
                     IARALVMQPDFVIADEPISALDVSVRAQVLNLLKKFQKELGLTYLFIAHDLSVVRFIS
                     DRIAVIYKGVIVEVAETEELFNNPIHPYTQALLSAVPIPDPILERKKVLKVYDPSQHD
                     YETDKPSMVEIRPGHYVWANQAELARYQKGLN"
     gene            18413..19222
                     /locus_tag="AC0DU4_001119"
     CDS             18413..19222
                     /locus_tag="AC0DU4_001119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4237086.1"
                     /translation="MDKLAKQGYVEGENIEIDLQNAQGEQRNLKTISQQLAESSDVVL
                     AIARPSAQSLANTTQTTPVIFSAVTDPVSAKLVESREHPGGNVTGTSDQSSDAISTQI
                     NLIKKVLPKAKTIGILYTQSEPNSVVQKDEAKRLLKEKGFTVVEKTILDSNNVKAAAE
                     SLMAEVDMVFVPTDNIISLTMETVKQVSIKHKVPVFGGSTEMIAVGGLYNYGTNYEEL
                     GRQTARMLIRVLKGEKPENIAVELPEKLELHTNQEMADALGIDISKLEGKE"
     gene            19234..20127
                     /locus_tag="AC0DU4_001120"
     CDS             19234..20127
                     /locus_tag="AC0DU4_001120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001012086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237087.1"
                     /translation="MNFVLSSLSEGLLWSIVAIGVYLTFRILDIADMTAEGAFPLGAA
                     VVVSQIQAGANPWLATLLALLAGMVAGLVSGMLHTKMKIPALLTGIVTLTGLYSINIK
                     IMGSVPNLSLGDSATVFKQLASLGLTNEGTVFSLSLACFLLVCLVLTLLMKTEIGLVL
                     RSTGDNIPMSEANGVNVDTMKIVGYMISNGLIALCGSLFAQNDGFSDVTSGTGTIVVG
                     LSSVIIAEVLIHDLTIGGRLLSIGIGAIVYRLIILNIYEIPNLDQNLVRLFNAILLAL
                     VLFAPELQKRLKIRGLKLRNE"
     gene            20140..20943
                     /locus_tag="AC0DU4_001121"
     CDS             20140..20943
                     /locus_tag="AC0DU4_001121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000157668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237088.1"
                     /translation="MTSLLTLENIHKTFEAGTVNENHVLKGLDLEVEEGDFISVIGGN
                     GAGKSTLMNILAGNLSVDEGDLLLAGKSIKNLSVRKRAKDIARVFQDPKMGTASRLTI
                     EENMAIALRRGQKRGLGWGVKEKDRIQFQEALKELNIGLENRLKVDTQYLSGGQRQAL
                     TLVMTDLMKPKLLLLDEHTAALDPKTSQMVMNLTQKIVEHHQWTTLMITHDMNHAIEY
                     GNRLIMLYQGKIVVDVKGEEKKHLTVEDLMHLFQKNSGQSLVSDELVLG"
     gene            complement(20976..21686)
                     /gene="treR"
                     /locus_tag="AC0DU4_001122"
     CDS             complement(20976..21686)
                     /gene="treR"
                     /locus_tag="AC0DU4_001122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="trehalose operon repressor"
                     /protein_id="HIN4237089.1"
                     /translation="MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVR
                     KALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLTSYQELVKELGLRSKTNVVSLDK
                     IIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIY
                     SYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTE
                     SRHKLEKFRFVDFAKRKK"
     gene            21871..>22499
                     /locus_tag="AC0DU4_001123"
     CDS             21871..>22499
                     /locus_tag="AC0DU4_001123"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose PTS transporter subunit EIIB"
                     /protein_id="HIN4237090.1"
                     /translation="MGKFEQEAKDLLQAIGGKENVTAVTHCATRMRFVLGDDKKANVK
                     AIESIPAVKGTFTNAGQFQVIIGNDVPIFYNDFTAVSGIEGVSKEAAKSAAKSNQNVV
                     QRVMTTLAEIFTPIIPALIVGGLILGFRNVLEGVHWSMLDGKTITESSQFWAGVNHFL
                     WLPGEAIFQFLPVGITWSVSRKMGTSQILGIVLGICLVSPQLLNAYAVAS"
BASE COUNT         6574 a         4003 c         4853 g         7069 t
ORIGIN      
        1 attgatagta tttatgcggg tgtagtttag tggtaaaact acagccttcc aagctgttgt
       61 cgcgagttcg attctcgtca cccgctttga actttgttca aattaccaag ttttttaact
      121 tgggcgcgta gctcaggtgg ttagagcgca cgcctgataa gcgtgaggtc ggtggttcga
      181 gtccactcgt gcccattaat tggagaatta ctcaagaggc tgaagaggac ggtttgctaa
      241 atcgttaggt cgggtaactg gcgcaagggt tcgaatccct tattctccgt tttaatgaga
      301 gtttgtaact ctcttttttg tttttagaga caataaaact tcagatccgt aaaacttaat
      361 tgaattacta atctgaagtt atttttatat cgtttatatt ataattgtgt tattttactt
      421 ccaactattg agagaaattt cgccactatt tagccagatt tcttttccgt tatcacattg
      481 aactaaaagt tttccatttt ctgagatgtc tttagcaagt cccttgtagt ctttttgctc
      541 tagtgtgaaa gtgacttctt ttcctagaat gaatgactgt tttttgtata ggtataatag
      601 ctcttctgct ggtgtttcga agaaagcacg ccagatttct atgatcaatt cattccttgt
      661 tataggagct gtagctttaa ataagctggc agctttttct tttaattcct gagggaagtc
      721 tttaatagtg aaattgatac ctactccaat aatgatatct gtgactaagc cagtttctac
      781 agaggtcatt gcttcagtaa ggattcctcc aattttatga ttgtttagat agatatcatt
      841 gacccatttt atatcgacat ctattaaagt taggttctta atggctttgt agacagctcc
      901 agctacaagt agtgtgtagg atggtaattt gtcatagggg agatttggtt taagatggag
      961 tgtcatataa attccacctt gtggtgagta gaaggaacgt tgaaaacggc ctcggcctgc
     1021 tgtttgatag gaagctagat agagagtatt tgcttcatgg cctaaatcaa ttgcttcttt
     1081 tgcatctagt tgtgttgatt ttgtttcggg tttaaagctg actttaattg gaagattttc
     1141 ttctagaatc tctggaagaa taaggtcacc attcattagt ttatatcctc tatttttgat
     1201 actattaatt tcaatgcctt cttgttctag tcgcttgata gctttccaaa ttgatgttcg
     1261 gcttagggat agtttttctg cgattttttc tccgctgata tagtcggttt ctttagatag
     1321 gatttggtag acagcttggt aggatttcat aatgttgcct ttctcactag ttggtattga
     1381 gagtattctt ttcttgtatg acttggagac tgattaaagt attgtttata agctttcgaa
     1441 aaatggagtg gatctgaaaa acctaccgag tatgcaatta ccttgatgga ctcttgggta
     1501 ttttcgagaa gttgtctagc tcggtgcatt cgaacgtaga gtaggtattc tttgggtgat
     1561 aaggtattaa attctttgaa tacgcttgat aagtagcttc tgtgaacgga tagttctttt
     1621 gctaaatctt gaattgtaag tgattgagga tagtggctat caattaatcg tttgcattca
     1681 agatagagtt ggtgggttga tgaaatattc ttttttttct gattgggagc aatagttccc
     1741 agatgaaaca tcagttcatg aagttgtccc atgatatgga gttgagctaa ttcacttgat
     1801 tttgtaatct gagcgaagcg gacaatgtct gagatgagtt ttgcagtagt ctgggtatga
     1861 caagtttcag attggatgag ataggattga tcagaaattt gagaaagagc aaaataatca
     1921 ggggatttcc ctccagtgat tcctaaccag tagtaggccc aaggttcttt actatctgct
     1981 tgataaaagg ttagttcctc tggttttaat agaaagaaat ctccttcttt taaatcaaca
     2041 attttaccct tgtaatgaaa ttttccttgt cctttactaa tgtaatgtag gacgtatgta
     2101 tcacgaatgg ctggaccaaa agagtaatta ggtgtgcatt cctcatatcc ataaaagctt
     2161 agggcaaggt caattgttcc agtctggtat tctgaaaaaa ctagcatgtg ctacctccta
     2221 cctaacattt taccatattc ttgagacatt tttctatttt ggaaagcgat ttcaggtgat
     2281 aaaatataat caataaagtg atgaggtgaa gtaaatggga gttaggatag agaataatct
     2341 attttatgtt gagagtaaaa atctaagttt gattattgaa aatcgaaatg gctacttact
     2401 tttgaaacat ttaggaaaga ctattaagaa ctataaaggt tccaatagtg tttatgaacg
     2461 agaccatgcc ttttcaggaa atccaacggc tactaatcga acctttagtt tagatactca
     2521 gcgacagatt tttggacaac atggcttagg agattttagg aaaccaacta tacaggttca
     2581 gcatagtgta actgaagtaa cagactttcg atttgtagaa gcaaagattt taaaaggtca
     2641 gaatggtcca cagggcttac cttctccaca tagcatggac gatacagaga ctcttgtctt
     2701 aatgttagaa gattctaagg ctcaacttag tctgactttg tattatacta cttttaataa
     2761 tgatgcgact attgctagct acagtaaatt agataataat agtaatcagg aagttgtcat
     2821 ccataaagat ttttctttta tggctgattt tccagctgca gattacgaaa tagtaactct
     2881 gcagggtgct tatgctcgtg aaaagactgt tagacgtcaa caggtagaac aaggaatctt
     2941 ttcgattagt tcaaaccgag gtgcttctgg tcatgctcaa acaccagctc ttctactatg
     3001 cgaacaagga gtcacagagg atgctgggaa tgtgtttgct attcaactaa tgtatagtgg
     3061 caactttgaa gcttttgttc aaaaaaatca attgaatgaa gttcgggtgg ctattggcat
     3121 taatccagaa aacttttctt ggaagttagc ccctgaggaa tactttgaaa caccggtagc
     3181 tttagtgact cattcagatc agggattaac tggtattagt catgaaagtc agaattttgt
     3241 actgaagcac attactctaa gtgaattttc taaaaaagaa cgtccaattc taatcaataa
     3301 ctgggaagct acttactttg actttcagag agaaaaactg ttagagttag cagatgaagc
     3361 taagaaagtt ggcattgaac tttttgtatt agatgatggt tggtttggca atcgttttga
     3421 tgataatcgt gctttaggtg attgggttgt taatgaggaa aaactgggtg gaagtctaga
     3481 aagtctgatt tcagctatcc atgaaagagg tttgcagttt ggactttggt tagaacccga
     3541 aatgatttct gtagatagtg atttgtatcg tcaacatcct gactgggcta ttcaggttcc
     3601 tgattatgag catacttatt ctcggaatca attagtactt aatcttgcca atcctcaggt
     3661 agtagaatac ttgaaaagtg tcttagatca actcctatct tatcatgaga ttgattacat
     3721 taaatgggat atgaaccgca atatcactaa gctagggaat ggattaactt atctagagac
     3781 acagatgcaa tctcatcagt acatgctggg actttacgaa ctcgtttctt atctgacaga
     3841 gaagcacagc catattctct ttgagtcctg ctctggtggt ggtggacgaa atgatcttgg
     3901 tatgatacgc tatttcccac aagtctgggc tagtgataat actgatgcca ttgcacgttt
     3961 accaattcaa tacggttcat cctatctcta tccaaccatt tctatggggg ctcatgtgtc
     4021 agcagtaccg aatcatcaga tgggacgaat gacaccatta gaaacacgtg gccatgtagc
     4081 aatgatggga aatttgggct atgagcttga tttgacaaat ttatcagatg aagagaaagc
     4141 tacgattgct aatcaggtga acttgtataa agaattacga ccagtagttc agttaggaca
     4201 gcagtataga ctaattaatc ctgatactgc atccaatgaa gcagctgtac aatttaatta
     4261 cggaaatcaa acgattgtaa cctacgttcg cgttttatct gttgtagaga ccatggaaac
     4321 aactttaaaa ttaaaagatt tggatgaaga gggactatat aaattacagg aaaatggcga
     4381 agtttactca ggtgcagaac taatgtatgc gggcttaact gttatcttat cccaaggaga
     4441 ttttttgagt agacagtata tttttagaaa actatgatat gtactgaccc caaaagttag
     4501 atttattctg tctaactttt ggggtgcagt tcaataaggg tgtataaatt tataaaggag
     4561 gctttctaat ggaatggtat aaaaaaatcg gacttcttgc aactacaggt ttagctttgt
     4621 ttgggctcgg cgcttgctcc aactatggta aatctgcgga tggcacagtg accatcgagt
     4681 atttcaacca gaaaaaagaa atgaccaaaa ccttggaaga aatcactcgt gattttgaga
     4741 aggaaaaccc taagatcaag gtcaaagtcg tcaatgtacc aaatgctggt gaagtattga
     4801 agacacgcgt tctcgcagga gatgtgcctg atgtggtcaa tatttaccca cagtccatcg
     4861 aactgcaaga atgggcaaaa gcaggtgttt ttgaagattt gagcaacaaa gactacctga
     4921 aacgcgtgaa aaatggctac gctgaaaaat atgctgtaaa cgaaaaagtt tacaacgttc
     4981 cttttacagc taatgcttat ggaatttact acaacaaaga taaattcgaa gaactgggct
     5041 tgaaggttcc tgaaacctgg gatgaatttg aacagttagt caaagatatc gttgctaaag
     5101 gacaaacacc atttggaatt gcaggtgcag atgcttggac actcaatggt tacaatcaat
     5161 tagcctttgc gacagcaaca ggtggaggaa aagaagcaaa tcaatacctt cgttattctc
     5221 aaccaaatgc cattaaattg tcggatccga ttatgaaaga tgatatcaag gtcatggaca
     5281 tccttcgcat caatggctct aagcaaaaga actgggaagg tgctggctat accgatgtta
     5341 tcggagcctt cgcacgtggg gatgtcctca tgacaccaaa tgggtcttgg gcgatcacag
     5401 cgattaatga acaaaaaccg aactttaaga ttgggacctt catgattcca ggaaaagaaa
     5461 aaggacaaag cttaaccgtt ggtgcgggag acttggcatg gtctatctca gccaccacca
     5521 aacatccaaa agaagccaat gcctttgtgg aatatatgac ccgtccagaa gtcatgcaaa
     5581 aatactacga tgtggacgga tctccaacag cgatcgaagg ggtcaaacaa gcaggagaag
     5641 attcaccgct tgctggtatg accgaatatg cctttacgga tcgtcacttg gtctggttgc
     5701 aacaatactg gaccagtgaa gcagacttcc ataccttgac catgaactat gtcttgaccg
     5761 gtgataaaca aggcatggtc aatgatttga atgccttctt taacccgatg aaagcggatg
     5821 tggattagga gtagagagac tatgaaaaaa gtattacaaa aatattgggc atgggctttt
     5881 gtggtcatcc ccctcttgtt acaagcaatt ttcttctatg tgccgatgtt tcaaggagcc
     5941 ttttacagtt ttaccaactg gacaggattg acttataact acaaatttgt cggcttaaac
     6001 aactttaagc tcctcttcat ggatccaaaa ttcatgaatg cgattggctt taccgcaatc
     6061 attacgattg ccatggtggt tggtgagatt gcactcggga tcttcattgc gcgtgtcttg
     6121 aactctaaaa tcaaaggcca aaccttcttc cgtgcttggt tcttcttccc agctgtttta
     6181 tctggtttga cagtggcttt gatcttcaag caagtcttca actacggtct tccagcgatt
     6241 gggaatgccc ttcatattga atttctccaa accagtcttt tagggactaa gtggggagca
     6301 atctttgcgg ctgcctttgt ccttctttgg caaggggtgg ctatgcccat catcatcttc
     6361 ctagctggtt tgcaatctat tccaactgag attacagagg cagcaaggat tgatggtgcg
     6421 actagcaagc aagttttctg gaacattgaa ttgccttact tgctaccaag tgtctctatg
     6481 gtctttatcc tagccctaaa aggtgggctg actgcctttg accaagtctt tgccatgacc
     6541 ggtggtggtc caaacaatgc cacaacctca cttgggctct tggtttataa ctatgccttt
     6601 aaaaacaacc aattcggtta tgccaatgcc attgccgtaa tcttgttcct cttaattgta
     6661 gtgatttcga tcatccaatt gagagtatct aagaaatttg aaatttaaga ggagaagcat
     6721 gatgaaacaa gatgaaagaa aagccctgat tggcaaatac attctattga ttctaggatc
     6781 ggttctgatt ttagtgccgc tccttgctac cctctttagt tccttcaaac ccactaagga
     6841 tattgtagat aatttctttg gctttccaac caacttcaca tgggacaact ttagccgtct
     6901 cttagctgat gggattggag gctattattg gaactctgtc gtcatcactg tcttgtcttt
     6961 acttgcagta atgatcttta tccctatggc agcctactcc atcgctcgca atatgagtaa
     7021 aagaaaagcc tttaccatca tgtataccct cttaatcctc ggaatcttcg tacctttcca
     7081 agtcatcatg attccgatta cggttatgat gagtaaactc ggtttggcta atacctttgg
     7141 tttgatcttg ctctacttga cctatgcgat tccacagacc ctctttctct atgttggcta
     7201 tatcaaaatc tcgattccag aaagtctgga tgaagcagca gagatcgatg gggctaatca
     7261 atttacaacc tatttccgca tcatcttccc aatgatgaaa ccgatgcatg cgacaaccat
     7321 gattatcaat gccctttggt tctggaatga cttcatgttg ccactccttg tcttgaaccg
     7381 ggattccaaa atgtggactc tgcctttgtt ccaatacaac tacgcaggcc aatatttcaa
     7441 cgactacgga ccaagctttg cctcttacgt ggtcggcatt atcagtatca ccattgtcta
     7501 tctcttcttc caacgccata tcatttcagg aatgagcaac ggggcagtga agtaatactc
     7561 aatgaaaatc aaagagcaaa ctaggaagct agccgcaggc tgtacttgag tacggcaagg
     7621 tgaagctgac gtggtttgaa gagattttcg aagagctcat ggaatctata gtctttgaca
     7681 cagaggaaga gtttagcttg ttgataattc tatgcagaaa acaagaaagt agtactttgt
     7741 ttatcacagt ctatattagt acgagtttga tgataaatag agatttaaaa tgaattttat
     7801 ttatgaagcc agatcatatg agacttggct tcaattagaa aaaggagagt aatgatgcca
     7861 attcaaaata aaaccatgtt gattacctat tctgatagcc ttggaaataa tcttaaagac
     7921 ttatatgata atttggaaga gcattttgga gatgctattg gaggagttca ccttttacca
     7981 tttttcccat caacaggtga tcgtggattt gcgccagttg actacgacga agtggactca
     8041 gcttttggtg attgggagga tgttaagcgt ttaggtgaga aatattatct tatgtttgat
     8101 tttatgatta atcatatttc tcgtcaatcc aagtattata aggactatca agaaaaacat
     8161 gaagccagtg aatttaaagc tctcttttta aactgggata agttttggcc agaaaaccgt
     8221 ccgacacagt ctgatgtaga tttaatttac aagcgtaagg atcgtgcacc aaagcaagag
     8281 attgtgtttg aagatggttc agtggaacat ttgtggaata cctttggtga ggagcagatt
     8341 gatcttgatg tgaccaaaga agtaactatg gaatttatcc gtaagaccat tcagcacttg
     8401 gcaagtaatg ggtgtgattt gattcgtcta gatgcctttg cttatgcagt gaagaaattg
     8461 gatactaatg atttctttgt ggaaccagat atttgggatt tattggacaa agttcgagat
     8521 atcgctgctg agtatgggac agagctttta cctgagattc atgaacacta ttcgattcag
     8581 tttaaaatag cagaccatga ttactatgtt tatgattttg ctcttccaat ggtgacactt
     8641 tatactcttt acagttccag aacagagcgt ttggctaagt ggttaaagat gagcccgatg
     8701 aagcaattta cgatgctaga tacccatgat gggattggag tagtagatgt caaggatatc
     8761 ctgaccgatg aggagattga ctatgcttca aatgaactct ataaggttgg agccaatgtc
     8821 aaacgtaagt actctagtgc cgagtataac aacttagata tctaccaaat caattcaacc
     8881 tactattcag cgcttggaga tgatgatgtc aagtattttc tcgctcgtct aattcaagct
     8941 tttgccccag gtattcctca ggtttactat gtgggtctat tagcaggcaa gaatgacttg
     9001 aaattattag aagaaactaa agaaggtcga aatattaatc gtcattacta tagcaacgag
     9061 gaaatagcaa aagaagtgca acgacctgtt gtgaaggccc ttctcaatct attttctttc
     9121 cgtaaccgtt cagaagcctt tgatctagaa gggactactg agatagagac accaacagct
     9181 cacagcattg taatcaaacg tcaaaataaa gataagtccg taacagcagt agtagaaatt
     9241 gatttgcaaa atcagactta tcgggtaatt gagaatggag ttgaagtatc attttgaagc
     9301 cttgatatgg tggataaaat agggttttta ttttggaaaa cgtttccttt gttttcaaat
     9361 tgctaaaaaa gtggtacaat ataggatagc ttactattat ctgaatcagc tgatttggag
     9421 agaaaggatt cattttgaaa tcaataggct ttattgaaaa gctgaagggg ttgtctagta
     9481 aagagctgat tttattggga attatcctaa gtatcttttt acccttttat ctttttgtag
     9541 ttgtactctg tttatatatt atcagtttga tttttacagg agacatgaaa agtattcttc
     9601 agaaaatggg ggagcatccg atgctgcttc tttttcttag ctatagtact gttatatcca
     9661 ttcttgcaca aaattggatg ggtcttgtgg cttcagtagg aatgtttcta tttactattt
     9721 tctttttgca ctatcagtcg attttatccc ataaattctt tcgattgatt ttgcagttcg
     9781 tcttgtttgg tagtgtcttg tcagctgctt ttgccagttt agaacatttc caaattgtga
     9841 agaaatttaa ctatgctttt ctttcaccca atatgcaggt gtggcatcag aaccgggcag
     9901 aagtgacctt ctttaatcct aattattatg gaattatttg ttgtttctgt attatgattg
     9961 ctttctatct gtttacaacg accaagttga attggttgaa agtattctgt gtgattgcag
    10021 gctttgttaa tctctttggt ttgaacttta ctcaaaatcg aactgccttt cctgctatta
    10081 tcgctggagc aattatctat ctctttacga ctattaaaaa ctggaaggcc ttttggctta
    10141 gtattggggt cttcgcgatt ggtttgagtt tcctcttttc tagtgatttg ggagttcgaa
    10201 tgggtacttt agactcttct atggaagaac gcatttctat ctgggatgct gggatggcct
    10261 tgtttaagca aaatcctttt tggggtgaag ggccattgac ctatatgcac tcttatcctc
    10321 ggatacatgc tccttatcat gaacatgccc acagtcttta tattgatacg attttgagtt
    10381 acggaattgt gggtaccatt ttattagttt tgtcttctgt tgctcctgtt cgcttgatga
    10441 tggatatgag tcaggagtcg gggaaacgtc cgattatcgg cctttatcta tctttcctta
    10501 cagtggttgc tgtgcacgga atttttgact tggctctctt ctggattcag tcaggcttta
    10561 ttttcttgct agttatgtgc agtattccat tggagcatcg aatgttggta tcggacatga
    10621 cggattaagt tttataagtt tgaaatcttc taccttgggt aggagatttt tttatacgat
    10681 gggcatgtcg tgcatctgag gtgtaagtcc tctgtaggga tccactaccg gtgaatacaa
    10741 tagcgctccc caagcctgac tatcgtgagg tagcggatta aaatggtctg gggatagatc
    10801 gttttaagtc tgacgcagga aataagaatt gtcagagaaa gcaatagtga aatcgtaggc
    10861 tatgaataga aacgtgatag cgaggagcat atagtggaca aggtagcgag aaattttaaa
    10921 gtataaaaga tagtcttaat ctatatgtgt aaatcacgaa agtaattgaa ttcggaataa
    10981 ggttggtgtg aaaagacata gtaaactgaa tcttgaatac tagaatgata cttctacaat
    11041 attgttataa tttaatttga attccaaaat cacattgttc cgtccgtatt tcattttact
    11101 gtatgtcttc ctaagctcca aaatttctgt gtcaaatttc ctattttcac tgtagtcttt
    11161 gacacttcga acgacaattt gaatcatata ttcaaaaaaa atgaaaaatt tgtgccaaca
    11221 agcctaaata ttctgaaaat ttgtttgatt tttaatggat aatgtgatat aatggttgtc
    11281 aatctataat tcacataaac agaggagtag aaaatgaaaa aaaatcgtgt atttgctaca
    11341 gcaggtcttg ttttattagc agcaggtgta cttgcagcat gcagttcttc aaaatcatct
    11401 gattcatcag cccctaaagc ttatggctat gtttatacag cagacccaga aaccttggac
    11461 tacctgattt caagtaaaaa tagtacaaca gtagtgactt caaatgggat tgatggttta
    11521 ttcactaacg ataattacgg taatcttgct cctgcagttg cagaggattg ggaagtctct
    11581 aaggatggtt tgacctacac ttataagatt cgtaaagggg ttaaatggtt tacctctgat
    11641 ggagaagaat atgcagaggt gacggctaaa gatttcgtga acggtttaaa acacgcagca
    11701 gataaaaaat cagaagctat gtatttagct gaaaattcgg ttaaaggctt ggcagattat
    11761 ctatcaggaa cttcaacaga tttttcaaca gttggtgtca aggcggttga tgattatacg
    11821 ttacaataca ctttgaacca gcctgaaccg ttctggaact ctaagttgac ctattctatt
    11881 ttctggcctc tgaatgaaga attcgaaaca tcaaaaggaa gcgattttgc taaaccaaca
    11941 gatccgacat ccttgcttta taatggtcca ttcttgttga aagggttgac tgcaaaatct
    12001 tctgtagagt ttgtaaaaaa tgagcaatat tgggataaag aaaatgtcca cctagatact
    12061 atcaatctag cttactatga tggatcagat caggagtcgc tagagcgtaa cttcactagt
    12121 ggagcttata gttatgcccg tctttaccct accagctcca actattctaa ggttgcagaa
    12181 gaatacaagg acaatatcta ttacacacaa tcaggctctg ggattgctgg tctgggtgtg
    12241 aatattgatc gccaaagtta caactatact tctaaaacta cagattcaga gaaagtagct
    12301 actaagaagg cattgcttaa caaagatttc cgtcaagcct tgaattttgc tcttgatcgc
    12361 tcagcttact cagctcaaat caatggtaaa gatggagcag ctttagcagt tcgtaattta
    12421 tttgtaaaac cagactttgt ttcagctggt gagaagacct ttggtgattt agtcgctgct
    12481 caacttcctg cttatggtga tgagtggaaa ggtgtgaatt tagctgatgg gcaggatggt
    12541 ttattcaatg ctgacaaggc caaggcagag tttgcgaaag ctaagaaagc tttagaagca
    12601 gacggcgttc agtttcctat tcatctggac gttccagtag accaagcatc aaaaaactat
    12661 atatctcgta ttcagtcctt taaacaatct gtagaaacag ttcttggtgt tgaaaatgtc
    12721 gttgttgata ttcaacaaat gacaagtgat gaattcctta atattactta ctatgctgcc
    12781 aatgcttcat ctgaggattg ggatgtatcg ggaggagttt catgggggcc agactatcaa
    12841 gacccatcta cttacctgga tattttaaaa acaactagca gtgaaactac aaaaacatat
    12901 ttaggatttg ataatccaaa tagcccttca gtagttcaag ttggtttgaa agaatacgat
    12961 aaattagttg atgaagctgc caaagagaca agcgacttga atgtccgtta tgaaaaatat
    13021 gcagcggctc aagcatggtt gacagatagt tcactcttta ttcctgctat ggcttcttct
    13081 ggtgcagcac cagtgctttc acgaattgtt ccatttactg gagcttctgc gcaaacaggc
    13141 tctaaggggt cagatgttta cttcaaatat ttgaaattac aagataaagc ggtgactaag
    13201 gaagagtatg aaaaagctcg tgaaaaatgg ttgaaagaaa aagctgaatc aaatgagaaa
    13261 gctcaaaaag aattggcaag tcatgtgaag taaataattt ctaatagaac tttctctcca
    13321 tgaggagaag gttcttttgg gatttttaaa ggaaataata tgaaaaaata tatttttatg
    13381 cgtgttttgc ggtcattggt ttcgattttc ttagtaacga ctttgaccta cacgattatc
    13441 tataccttgg ttcctcgaaa attgattttc aagcaggatc ctaactataa taaaattgcg
    13501 acaacggctg ataaacgtga taactatgaa aatactgtgt ttgagcgtat gggctacatt
    13561 gagtattacg atactaaaga gttgcaagaa aaggcaagta gcatggattc ttctgtaaca
    13621 gtagaagcaa atgcgaccaa taaagctatt tatgaaaagt acatcaatca attaggtcat
    13681 ggttggactt tgggagaatt tactgaaagt ggtcaattct atgctactcg tgaaattcca
    13741 atttttgaac gtgtttttca cttctatgct aacttgattg acattgacca tacaaataaa
    13801 atccaagacc ctgaaaatcc agacttgaaa cgctaccttc gttttgaaaa tgatccagct
    13861 atcggatggt cattggtcgg ttcaggaact aaacataaat atctcttgta ctttaacagt
    13921 cagttcccat ttgttcatca aaactttgtg aacttgaatt taggtgactc ttacccaacc
    13981 tatgctaata caccagttct tcaggttatt actcaaggtc aaggacaaac caaaactgcc
    14041 caagttcagt tcccaacagg taagaaaacg tcttctgtaa atatttactc aagaacctac
    14101 aagtcaccta gtcaggctga ctctcgtgaa gtagctagct atgggaaaga tgatccttat
    14161 acagcgactg aaagtaatta ccaatatcca tctatgattg tcagctctgc tattactggt
    14221 ttgattggtt tggttcttgc ctatgctctt gccgtgccac ttggttcagc catggctcgt
    14281 ttcaagaaca cttggattga tagcctctca acaggggctt tgaccttctt gcttgctctt
    14341 ccaacgattg ccttggttta catcgttcga ttgattggat catctatttc ccttccagat
    14401 tcattcccta tcttgggagc tggagattgg cgttcttacg ttttaccagc agtcatcctt
    14461 ggtttgttgg gtgctcctgg tacagccatt tggattcgtc gttacatgat tgacttgcaa
    14521 tctcaagact ttgttcgttt cgctcgtgca aaaggtttgt ctgaaaaaga aatttcaaac
    14581 aaacacatct ttaaaaatgc catggttccg ctggtttcag gaattcctgg tgccattatt
    14641 ggggttatcg gtggtgcaac ccttactgaa acagtcttcg ccttcccagg tatgggtaaa
    14701 atgttgattg actctgtaaa agcatctaat aactctatgg tcgttggtct tgtcttcatc
    14761 tttacatgta tttctatctt ctcacgtctt ttgggagata tttggatgac tattattgac
    14821 ccacgtatta aattgactga gaaaggaggc aaataatgtc tacaatcgat aaagaaaaat
    14881 ttcagtttgt aaaacgtgac gattttgcct ctgaaactat tgatgcgcca gcatattctt
    14941 actggaaatc agtgtttaaa caatttatga agaaaaaatc aactgtagtc atgttgggaa
    15001 tcttggtagc catcattttg ataagtttca tctacccaat gttttctaag tttgatttca
    15061 atgatgtcag caaggtaaac gactttagtg ttcgttatat caagccaaat gcggagcatt
    15121 ggttcggtac tgacagtaac ggtaaatcgc tctttgacgg tgtctggttc ggagctcgta
    15181 actccatcct catttctgtg attgcgacag tgattaactt ggttatcggt gtttttgtcg
    15241 gtggtatttg gggtatttca aaatcagttg accgtgtcat gatggaagtt tacaacgtca
    15301 tctcaaacat cccacctctt ttgattgtta ttgtcttgac ttactcaatc ggagctggat
    15361 tctggaatct gatttttgcc atgagcgtaa caacatggat tggtattgcc ttcatgatcc
    15421 gtgtgcaaat cttgcgctat cgtgacttgg aatacaactt ggcgtcacgt actttgggaa
    15481 caccaacctt gaagattgtt gccaaaaata tcatgcctca attggtatct gttattgtga
    15541 caaccatgac tcaaatgctt ccaagcttta tctcatacga agccttcttg tctttcttcg
    15601 gtcttggatt accgattaca gtgccaagtt tgggtcgttt gatttcggat tattcacaaa
    15661 acgtaacaac caatgcttac ttgttctgga ttccattgac aacccttgtc ttggtatcct
    15721 tgtccctttt cgtagttggt caaaacttag cggatgctag tgatccacgt acacatagat
    15781 aggagtagaa atgacaaaag aaaaaaatgt aattttgact gctcgcgata ttgtcgtgga
    15841 atttgacgtt cgtgacaaag tattgacagc cattcgcggc gtttcccttg aactagtcga
    15901 aggagaagta ttagccttgg taggtgagtc aggatcaggt aaatctgttt tgacaaagac
    15961 cttcacaggt atgctcgaag aaaatggtcg cattgcccaa ggtagtattg actaccgtgg
    16021 tcaggacttg acagctttat cttctcacaa ggattgggaa caaattcgtg gtgctaagat
    16081 tgcgactatc ttccaggacc caatgactag tttggacccc attaaaacaa ttggtagtca
    16141 gattacagaa gttattgtaa aacaccaagg aaaaacagct aaagaagcga aagaattggc
    16201 cattgactac atgaataagg ttggcattcc agacgcagat agacgtttta atgaataccc
    16261 attccaatat tctggaggaa tgcgtcaacg tatcgttatt gcgattgccc ttgcctgccg
    16321 acctgatgtc ttgatctgtg atgagccaac aactgccttg gatgtaacta ttcaagctca
    16381 gattattgat ttgctaaaat ctttacaaaa cgagtatcat ttcacaacaa tctttattac
    16441 ccacgacctt ggtgtggtgg caagtattgc ggataaggta gcggttatgt atgcaggaga
    16501 aatcgttgag tatggaacgg ttgaggaagt cttctatgac cctcgccatc catatacatg
    16561 gagtctcttg tctagcttgc ctcagcttgc tgatgataaa ggggatcttt actcaatccc
    16621 aggaacacct ccgtcacttt atactgacct gaaaggggat gcttttgcct tgcgttctga
    16681 ctacgcaatg cagattgact tcgaacaaaa agctcctcaa ttctcagtat cagagacaca
    16741 ttgggctaaa acttggcttc ttcatgagga tgctccaaaa gtagaaaaac cagctgtgat
    16801 tgcaaatctc catgataaga tccgtgaaaa aatgggattt gcccatctgg ctgactagga
    16861 ggaaggaaat gtctgaaaaa ttagtagaaa tcaaagattt agaaatttcc ttcggtgaag
    16921 gaagtaagaa gtttgtcgcg gttaaaaatg ctaacttctt tatcaacaag ggagaaactt
    16981 tctcgcttgt aggtgagtcc ggtagtggga aaacaactat tggtcgtgct atcatcggtc
    17041 taaatgatac aagtaatgga gatatcattt ttgatggtca aaagattaat ggtaagaaat
    17101 cgcgtgaaca agctgcggaa ttgattcgtc gaatccagat gattttccaa gaccctgccg
    17161 caagtttgaa tgaacgtgcg actgttgatt atattatttc tgaaggtctt tacaatcacc
    17221 gtttatttaa ggatgaagaa gaacgtaaag agaaagttca aaatattatc cgtgaagtag
    17281 gtcttcttgc tgagcacttg actcgttacc ctcatgaatt ctcaggcggt caacgtcaac
    17341 gtatcggtat tgcccgtgcc ttggtcatgc aaccagactt tgttattgca gatgagccaa
    17401 tttcagcctt ggacgtttct gtacgtgccc aagtcttgaa cttgctcaaa aaattccaaa
    17461 aagagctcgg cctgacctat ctcttcatcg cccatgactt gtcggttgtt cgctttattt
    17521 cagatcgtat cgcagttatt tacaagggtg ttattgtaga ggttgcagaa acagaagaat
    17581 tgtttaacaa tccaattcac ccatatactc aagccttgct ttcagcggta ccaatcccag
    17641 atccaatctt ggaacgtaag aaggtcttga aggtttacga cccaagtcaa cacgactatg
    17701 agactgataa gccatctatg gtagaaatcc gtccaggtca ctatgtttgg gcgaaccaag
    17761 ccgaattggc acgttatcaa aaaggactaa actagtaatg gttttataat ttccatgtca
    17821 atttttatgg aaattataaa actttttttg ttggactgat ttgaaaaact ttgaaagctt
    17881 cctgaaagaa tttttgaaaa attttaaaaa ttatgaaatg ttattgacag gtgatgaaaa
    17941 aggtggtagg acaggaagca tcaaaaaaga aagcagaaaa agaaatgaat aagagacaag
    18001 ccgtaactat gaatcaaaac ttttacttta gctactttag atagtgtttg tagacatgtc
    18061 accatggatg caaacagttc aagcaatttg tttgtatcta tgtggctaag atttttgatt
    18121 gtggtccata tagatgaata tctaaatgga ctagctaagt tgtaacttgt taggttattt
    18181 caagtatccg tttagatagt atctaggcgg ttttttgttt tatcttttct gagaaggagt
    18241 ttcattatga aagttgttcg aaaatcacta gccccctctt ggtagtgggg ctcctcttga
    18301 cttctctgat cagtttgcat cagttgaagg cagataagaa aaagatgtct ttcgtatcgg
    18361 tatttcgcaa tttattaccc accagtcctt atacgctact agagaaggat ttgtggataa
    18421 gctggccaaa caaggctatg ttgaggggga aaatattgag attgatttgc aaaatgcaca
    18481 gggagaacaa agaaatctaa aaacgatttc ccagcaacta gcagaatcca gcgatgtcgt
    18541 tctagccatc gcaaggcctt ctgctcagag cttggccaat acgacgcaaa cgacaccagt
    18601 tatcttttca gctgtaacag acccagtcag tgccaagttg gttgagtcaa gagaacatcc
    18661 tgggggcaat gtaactggga caagcgatca gtcatcagat gccatttcaa cccaaatcaa
    18721 tttgataaag aaagtgttgc caaaggctaa aacgattgga atcctctata ctcagagcga
    18781 gcccaattcg gttgttcaaa aggatgaagc taagcgactt ctgaaagaaa aaggctttac
    18841 cgttgttgaa aaaacaatct tggacagtaa taacgtcaag gcggcagcag agagtttgat
    18901 ggcagaggtg gatatggttt ttgtcccaac tgataatatc atttcgttaa ccatggaaac
    18961 agttaagcag gtttctatta aacacaaggt tccagtattc ggtggttcaa cagaaatgat
    19021 tgctgttggt ggcttgtata actacggaac caattatgaa gaattgggac gtcagacagc
    19081 tcgcatgctg attcgtgttt taaaaggtga gaaaccagaa aatatagcag ttgagttgcc
    19141 tgaaaaactg gaattgcata ccaatcaaga aatggcagat gcattgggaa ttgatattag
    19201 taagttagaa ggcaaggaat aaggaggatt aagatgaatt ttgtgttatc tagtttatca
    19261 gaaggtttgt tgtggtcgat tgtggcgatt ggggtctact tgactttccg tattttggat
    19321 attgcggata tgactgctga gggagccttt cctctggggg cagcagtcgt tgtatcacag
    19381 atacaggcag gggcaaatcc ttggcttgcg actttacttg ctttgctggc aggtatggta
    19441 gcaggtcttg tatcaggaat gctccacacc aagatgaaaa tcccagctct cttgacaggg
    19501 attgtgacct tgacagggct ctattcaatc aatattaaaa tcatgggcag tgtacccaat
    19561 ctttccttgg gagattctgc aaccgtcttt aaacagttgg cgagcttggg tctgacaaat
    19621 gaaggaactg ttttctcact tagtttggcc tgttttttac ttgtttgttt ggtcttgacc
    19681 cttttgatga aaacagagat tggcttggtc ttgcgttcga ctggggataa tatcccgatg
    19741 agtgaggcca atggagtcaa tgtagacacc atgaagattg ttggttacat gatttcaaac
    19801 ggtttgattg ctctatgtgg ttccttgttt gcccaaaatg atggattttc agatgtgact
    19861 tctgggacag gaaccattgt tgttggtttg agctcggtga ttattgcgga agtcttgata
    19921 cacgacttga ccattggagg ccgcttatta tccatcggaa tcggtgctat tgtttaccgt
    19981 ttgattattt taaatatcta tgaaattcca aatctagatc aaaacttggt acgtctcttt
    20041 aatgcaatct tgctcgcttt ggttttattt gcaccagaat tgcaaaagag attaaagatt
    20101 cgtggtctga aattgagaaa tgaataggag gagaaagtta tgacaagttt gttaacactt
    20161 gaaaatattc acaagacatt tgaagcaggg acggtcaatg agaaccatgt cctcaaagga
    20221 ttagatttag aggttgaaga gggagatttt atctctgtga ttggtggaaa tggagcagga
    20281 aaatccactt tgatgaatat cttggctggc aatctatcgg tggacgaagg ggaccttcta
    20341 ctggcaggga aatccattaa aaatctgagt gtcagaaaga gagccaagga tattgcccgt
    20401 gtttttcaag atcctaagat gggaacagct tctcgtttga cgattgagga gaatatggct
    20461 attgccttga gacgcgggca gaagagaggg cttggttggg gcgtgaagga gaaggataga
    20521 atccagttcc aagaggcctt gaaggagttg aatattggtc ttgaaaaccg cttaaaagta
    20581 gatactcaat atctctcagg aggacaaaga caggctttga ctctagtcat gacagatctg
    20641 atgaaaccaa aacttttact tttggatgaa catactgcgg cacttgaccc gaaaaccagt
    20701 caaatggtga tgaacttgac gcaaaagatt gtggagcacc atcagtggac gactttgatg
    20761 attacccatg atatgaatca tgcgattgag tacggcaatc gtctcattat gctctatcaa
    20821 ggcaagatag tggtggatgt caagggagaa gagaaaaagc atctgacagt tgaagacctt
    20881 atgcatctct tccagaaaaa tagtggccaa agtctggtca gtgatgaatt agttttggga
    20941 taaagaaaaa ggctgagatc tggtgtctca gtcttttatt tcttgcgttt tgcaaaatct
    21001 acaaatctaa atttctctaa cttatggcga ctttcggtaa actgaaattg gcgtccgtct
    21061 tggagataga cttttgattt aatcgaaacg acataagggt ctttgccaat gtccatgaga
    21121 atcttgtctc ggtcgcttga gtggtcaatg gtgatttcct tctgagcata atcaataagg
    21181 agtttgaggc cattttctat ataagaatag atagactgct cagcaatttg gcgagtgaga
    21241 tttggaatta gttccatatc cagatagtcc gtatccagaa cggataccag atcatccacc
    21301 acacgctggc ggaccacctt ccaaaccatc cgaaactctg ggaaaccggt tatcagtgag
    21361 gattttttat caataataat cttgtccaga ctgaccacgt tggttttaga gcgcagtcca
    21421 agttctttaa ctagttcttg gtagctggtt aggttggata cagggaaatt gacggtttct
    21481 tctttgacga cttgagaacc ttgccctctt atctttttga tcaatccttc ctcttggagg
    21541 agagacaggg cctttcggac ggtatcacga ctcacttgat attgctccat aaggtcgtgc
    21601 tcgctaggaa ggaaatctcc gacagcgtaa gtctcgtttt gaatggtttc ttggatttgc
    21661 ttaaataatt gttggtattt cttcattttg cctgcttaaa taggttttta gtctagttta
    21721 atgaacacct gtatctattt taccatacaa gtgctagaaa atttacaaaa aaacaccctt
    21781 tttataccaa acaagttgca gacaagtttg gtatcgttta caatatactt atcaaatcaa
    21841 acttgctttg acaagtataa ggagaatcaa atgggaaaat ttgaacaaga agccaaagat
    21901 ctgcttcagg caatcggagg caaagaaaat gtgactgccg taactcactg tgcgacacgg
    21961 atgcggtttg ttttaggaga tgataagaag gctaatgtta aagctatcga gtcaattcca
    22021 gctgttaaag gaacctttac aaatgcaggt caatttcagg taatcattgg aaatgacgtg
    22081 cccatctttt ataatgattt tacagccgtt tcaggtattg agggtgtttc caaagaagca
    22141 gccaagtctg cagctaagag taatcaaaac gtggtccaac gtgttatgac cactctggcg
    22201 gaaatcttta ctccgattat tccagccttg attgttggtg gattgatcct cggtttccgt
    22261 aatgtcttgg aaggtgtcca ttggtcgatg ttggatggca agaccatcac agaatcctct
    22321 cagttttggg caggggttaa tcacttcctc tggttgcctg gtgaagctat cttccagttc
    22381 ttaccagtag ggattacttg gtctgtttct cgtaagatgg gaaccagcca aattttggga
    22441 attgttctcg gaatctgttt ggtatcgcct cagttgctca atgcctatgc ggttgcttc
//
LOCUS       DBMVGT010000026        22213 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.026, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000026 DBMVGT010000000
VERSION     DBMVGT010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 22213)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 22213)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22213
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.026"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(381..1577)
                     /gene="tuf"
                     /locus_tag="AC0DU4_001124"
     CDS             complement(381..1577)
                     /gene="tuf"
                     /locus_tag="AC0DU4_001124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014335040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HIN4237091.1"
                     /translation="MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSV
                     NQPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQM
                     DGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDL
                     LSEYDFPGDDLPVIQGSALKALEGDSKYEDIVMELMNTVDEYIPEPERDTDKPLLLPV
                     EDVFSITGRGTVASGRIDRGIVKVNDEIEIVGIKEETQKAVVTGVEMFRKQLDEGLAG
                     DNVGVLLRGVQRDEIERGQVIAKPGSINPHTKFKGEVYILTKEEGGRHTPFFNNYRPQ
                     FYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGM
                     VTEIEA"
     gene            complement(2499..3368)
                     /gene="gla"
                     /locus_tag="AC0DU4_001125"
     CDS             complement(2499..3368)
                     /gene="gla"
                     /locus_tag="AC0DU4_001125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000348128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015267 - channel activity [Evidence IEA];
                     GO_process: GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aquaglyceroporin Gla"
                     /protein_id="HIN4237092.1"
                     /translation="MDFTWALKYATEFLGTAILIILGNGAVANVELKGTKGHQSGWIV
                     IAVGYGMGVMIPALMFGNVSGNHINPAFTLGLAVSGLFPWAQVVPYIIAQVLGAIFGQ
                     ALVVATYRPFYLKTENPNNILGTFSTISSIDHGTKESRYAATVNGLINEFVGSFVLFF
                     AALGLTKNFFGAEVLQFMKQKAIEAGQTVDFSDLAIKAQVAPHTASGLSVAHLALGFL
                     VMALVTSLGGPTGPALNPARDLGPRLLHAFLPKSVLGEHKGDSKWWYSWVPVVAPIAA
                     AIAAVAVFKFLYL"
     gene            complement(3592..4212)
                     /locus_tag="AC0DU4_001126"
     CDS             complement(3592..4212)
                     /locus_tag="AC0DU4_001126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mucin-binding protein"
                     /protein_id="HIN4237093.1"
                     /translation="MVPKTATSTETKTITRIIHYVDKVTNQNVKEDVVQPVTLSRTKT
                     ENKVTGVVTYGEWTTGNWDEVVSGKIDKYKAPDIPTVESQEVTSDSSDKEITVRYDRL
                     STPDKPTPEKPIPQPNPEHPSVPTPNPELPNQETPIPEPTPEPGTPKTETPVNLDPEV
                     PTYETGKREGLSNTGTEANATLASAGIMTLLASLVLGFFKKKEDEK"
     gene            complement(4170..5276)
                     /locus_tag="AC0DU4_001127"
     CDS             complement(4170..5276)
                     /locus_tag="AC0DU4_001127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MucBP domain-containing protein"
                     /protein_id="HIN4237094.1"
                     /translation="MNIILIAKLLRENTNTKANALNNGWARSGSEEFKKFSHFVGVDK
                     GIVRTNVLTGKKLSDKIRKEVGSGDSKLGKGGYFSTGDVLLGKDVVSYTVQVFSENNE
                     RVGVNTQSHRVQYNLPILADFSVIQDTVEPSRTVVEKIIPKLNIPEEEKGKITEEIKK
                     KKKTSELAELISENVKVRYVDEQGRLLSLKNDTGIGEKESDGTYITNKKQLIGTSYNV
                     TDKKLSSMTTTDGKYYTFKEVDTNSASLTGNIVSEGRTVTLVYRESEAPTTVTVTANY
                     YKEGSQEKLAESVIKADLAIGSEYTTESKTIEGKTTTEDKENRVITRKTTYTLVATPA
                     NAYQKTVQQLTITTVRMLRKQWFPKQQPLLRRRL"
     gene            complement(5387..5641)
                     /locus_tag="AC0DU4_001128"
     CDS             complement(5387..5641)
                     /locus_tag="AC0DU4_001128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237095.1"
                     /translation="MLNVDQDFMSISKSNKSGSDWKKTFTVRTTNRLANDLNNVLKQA
                     DKDTPNTPTWLNSAASKAKDDDRAYKLLKTLIPGENYLSC"
     gene            complement(5635..5877)
                     /locus_tag="AC0DU4_001129"
     CDS             complement(5635..5877)
                     /locus_tag="AC0DU4_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000284543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237096.1"
                     /translation="MVQNEDLYKKGLNVELAHQQIKGFFEAEFKNRINGVLNTKIKNS
                     TLNRVNKKTIHQSNKNSMINLKQKQRKMLKNKAILC"
     gene            complement(5981..6825)
                     /locus_tag="AC0DU4_001130"
                     /pseudo
     CDS             complement(5981..6825)
                     /locus_tag="AC0DU4_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078372828.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            7059..8777
                     /locus_tag="AC0DU4_001131"
     CDS             7059..8777
                     /locus_tag="AC0DU4_001131"
                     /EC_number="5.4.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HIN4237097.1"
                     /translation="MSYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGT
                     AGMRGLVGAGTNRINIYVVRQATEGLARLIESKGGNEKERGVAIAYDSRHFSPEFAFE
                     SAAVLAKHGIKSYVFESLRPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDG
                     GQMPPHDADALTTYIRAIENPFAVEVADVETEKASGLIEVIGEAVDIEYLKEVKDINI
                     NPALIEEFGKDMKIVYTPLHGTGEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSP
                     NPESQAAFALAEELGRQVGADVLVATDPDADRVGVEVLQKDGSYLNLSGNQIGAIMAK
                     YILEAHKNAGTLPENAALCKSIVSTDLVTKIAESYGATMFNVLTGFKFIAEKIQEFEE
                     KHNHTYMMGFEESFGYLIKPFVRDKDAIQAVLVVAELAAYYRSRGLTLADGIEEIYKE
                     YGYYAEKTISVTLSGVDGAEQIKAIMAKFRNNAPTEWNATAITVVEDFKAQTATVADG
                     TVTNLTTPPSDVLKYTLADGSWIAVRPSGTEPKIKFYIAVVGETNEESQAKIANIEAE
                     INAFVK"
     gene            8888..9235
                     /locus_tag="AC0DU4_001132"
     CDS             8888..9235
                     /locus_tag="AC0DU4_001132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HIN4237098.1"
                     /translation="MEQFLDNIKDLEVTTVVRAQEALDKKETATFFIGRKTCPYCRKF
                     AGTLSGVVAETKAHIYFINSEEPSQLNDLQAFRSRYGIPTVPGFIHITDGQINVRCDS
                     SMSAQEIKDFAGL"
     gene            complement(9514..10350)
                     /locus_tag="AC0DU4_001133"
     CDS             complement(9514..10350)
                     /locus_tag="AC0DU4_001133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4237099.1"
                     /translation="MKKWMLVLVSLMTALFLVACGKNSSETSGDNWSKYQSNKSITIG
                     FDSTFVPMGFAQKDGSYAGFDIDLATAVFEKYGITVNWQPIDWDLKEAELTKGTIDLI
                     WNGYSATDERREKVAFSNSYMKNEQVLVTKKLSGITTAKDMTGKTLGAQAGSSGYADF
                     EANPELLKNIVANKEANQYQTFNEALIDLKNDRIDGLLIDRVYANYYLEAEGVLNDYN
                     VFTVGLETEAFAVGARKEDTTLVKKINEAFSSLYKDGKFQEISQKWFGEDVATKEVKE
                     GQ"
     gene            complement(10363..10992)
                     /locus_tag="AC0DU4_001134"
     CDS             complement(10363..10992)
                     /locus_tag="AC0DU4_001134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000891751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015424 - ABC-type amino acid transporter
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HIN4237100.1"
                     /translation="MLELRNINKVFGDKQILSNFSLNIPEKQILAIVGPSGGGKTTLL
                     RMLAGLETIDSGQIFYNGQPLELDELQKRNLLGFVFQDFQLFPHLSVLENLTLSPVKT
                     MGMKQEEAEKKASELLEQLGLGGHAEAYPFSLSGGQKQRVALARAMMIDPEIIGYDEP
                     TSALDPELRLEVEKLILQNRELGMTQIVVTHDLQFAENIADVLLKVEPK"
     gene            complement(11002..11643)
                     /locus_tag="AC0DU4_001135"
     CDS             complement(11002..11643)
                     /locus_tag="AC0DU4_001135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HIN4237101.1"
                     /translation="MSYLFEILPSLLNGASTTVQVFALVLLFSIPLGVLIAFALQVHW
                     KPLHYLINIYIWVMRGTPLLLQLIFIYYVLPSIGIRLDRLPAAIIAFVLNYAAYFAEI
                     FRGGIDTIPRGQYEAAKVLKFSPFDRVRYIILPQVTKIVLPSVFNEVMSLVKDTSLVY
                     ALGISDLILASRTAANRDASLVPMFLAGAIYLILIGIVTIISKKVEKKYSYYR"
     gene            complement(11789..13018)
                     /locus_tag="AC0DU4_001136"
     CDS             complement(11789..13018)
                     /locus_tag="AC0DU4_001136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HIN4237102.1"
                     /translation="MNNSQQMLQALEEQDLTKAEHYFAKALENDSSDLLYELATYLEG
                     IGFYPQAKEIYLKIVEDFPEVHLNLAAIASEDGQIEEAFTYLEEIQADSDWYVSSLAL
                     KADLYQLEGLTDVAREKLLEALTYSEDSLLILGLAELDSELENYQAAIQAYAQLDNRS
                     IYEQTGISTYQRIGFAYAQLGKFETATEFLEKALELEYDDLTAFELASLYFDQEEYQK
                     ATLYFKQLDTISPDFEGYEYGYSQALHKEHQVQEALRIAKQGLEKNPFETRLLLAASQ
                     FSYELHDASGAENYLLTAKEDAEDTEEILLRLATIYLEQERYEDILDLQSEEPENLLT
                     KWMIARSYQEMDDLDTAYEHYQELTGDLKDNPEFLEHYIYLLRELGHFEEAKVHAHTY
                     LKLVPDDVQMQELFERL"
     gene            complement(13008..14174)
                     /locus_tag="AC0DU4_001137"
     CDS             complement(13008..14174)
                     /locus_tag="AC0DU4_001137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA];
                     GO_process: GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HIN4237103.1"
                     /translation="MEQKEKHFSLSWFFKWFLDNKAITVFLVTLLLGLNLFILSKISF
                     LFSPVLDFIAVVMLPVILSGLLYYLLNPIVDWMEKHKVNRVIAITIVFVIIALFIIWG
                     LAVAIPNLQRQVLTFARNVPVYLEDIDRIVNGLVAQHLPDDFRPQLEQVLTNFSSQAT
                     VLASKVSSQAVNWVSAFISGASQVIVALIIVPFMLFYLLRDGKGLRNYLTQFIPRKLK
                     EPVGQVLSDVNQQLSNYVRGQVTVAIIVAVMFIIFFKIIGLRYAVTLGVTAGILNLVP
                     YLGSFLAMLPALVLGLIAGPVMLLKVVIVFIVEQTIEGRFVSPLILGSQLNIHPINVL
                     FVLLTSGSMFGIWGVLLGIPVYASAKVVISAIFEWYKVVSGLYELEGEEVKSEQ"
     gene            14318..15331
                     /locus_tag="AC0DU4_001138"
     CDS             14318..15331
                     /locus_tag="AC0DU4_001138"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0052689 - carboxylic ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lactonase family protein"
                     /protein_id="HIN4237104.1"
                     /translation="MKETVYFGTYTRRTSQGIYKADFDTETGQLSNLELFAAEPSPTY
                     LAFDQHQHLYTVGSQDDKGGIAAYQTDGTVLNHVVEEGAPHCYVAVDEKRDLVYAANY
                     HKGQVLVYKRQEDGSLLLSDMDQHSGQGPHENQASPHVHYTDLTPDHYLVTCDLGTDQ
                     VITYDLDQEGKLSKLYTYHSKPGAGSRHIIFHNHYKIAYLICELNSTIEVLIYDGVGE
                     FERMQVISTLPEAYEGFNGTAAIHLSKDGKYLYASNRGHDSIAVYTILADGSLELLEI
                     VPTHGQTPRDFDLTPDQKFLIVVHQDSDNATVFKRNCDNGRLAELSNDFHVPEAVCIR
                     FAP"
     gene            complement(15376..15795)
                     /locus_tag="AC0DU4_001139"
     CDS             complement(15376..15795)
                     /locus_tag="AC0DU4_001139"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045259 - proton-transporting ATP
                     synthase complex [Evidence IEA];
                     GO_function: GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit epsilon"
                     /protein_id="HIN4237105.1"
                     /translation="MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAV
                     LAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLR
                     AERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL"
     gene            complement(15806..17212)
                     /gene="atpD"
                     /locus_tag="AC0DU4_001140"
     CDS             complement(15806..17212)
                     /gene="atpD"
                     /locus_tag="AC0DU4_001140"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045259 - proton-transporting ATP
                     synthase complex [Evidence IEA];
                     GO_function: GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HIN4237106.1"
                     /translation="MSSGKIAQVIGPVVDVLFAAGEKLPEINNALVVYKNDERKTKIV
                     LEVALELGDGMVRTIAMESTDGLTRGMEVLDTGRPISVPVGKETLGRVFNVLGDTIDL
                     EAPFTEDAERQPIHKKAPTFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVG
                     KTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEP
                     PGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQP
                     TLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLVQ
                     LGIYPAVDPLASSSRALAPEIVGEEHYAVAAEVKRVLQRYHELQDIIAILGMDELSDE
                     EKTLVARARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILDGKYDHLPEDAF
                     RGVGSIEDVIAKAEKMGF"
     gene            complement(17298..18176)
                     /locus_tag="AC0DU4_001141"
     CDS             complement(17298..18176)
                     /locus_tag="AC0DU4_001141"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002895995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045259 - proton-transporting ATP
                     synthase complex [Evidence IEA];
                     GO_function: GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit gamma"
                     /protein_id="HIN4237107.1"
                     /translation="MAVSLNDIKTKIASTKNTSQITNAMQMVSAAKLGRSEEAARNFQ
                     VYAQKVRKLLTDILHGNGAGASTNPMLISRSVKKTGYIVITSDRGLVGGYNSSILKAV
                     MELKEEYHPDGKGFEMICIGGMGADFFKARGIQPLYELRGLADQPSFDQVRKIISKTV
                     EMYQNELFDELYVCYNHHVNTLTSQMRVEQMLPIVDLDPNEADEEYSLTFELETSREE
                     ILEQLLPQFAESMIYGAIIDAKTAENAAGMTAMQTATDNAKKVINDLTIQYNRARQAA
                     ITQEITEIVAGASALE"
     gene            complement(18192..19697)
                     /gene="atpA"
                     /locus_tag="AC0DU4_001142"
     CDS             complement(18192..19697)
                     /gene="atpA"
                     /locus_tag="AC0DU4_001142"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045259 - proton-transporting ATP
                     synthase complex [Evidence IEA];
                     GO_function: GO:0046933 - proton-transporting ATP synthase
                     activity, rotational mechanism [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HIN4237108.1"
                     /translation="MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGL
                     ENVMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGES
                     LIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIG
                     RGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGAL
                     DYTIVVTASASQPSPLLFLAPYTGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLL
                     LRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNV
                     ISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYREL
                     EAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPV
                     DDIVRFEEEFHAFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ"
     gene            complement(19712..20248)
                     /locus_tag="AC0DU4_001143"
     CDS             complement(19712..20248)
                     /locus_tag="AC0DU4_001143"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HIN4237109.1"
                     /translation="MDKKTVKVIEKYSMPFVQLVLEKGEEDRIFSDLTQIKQVVEKTG
                     LPSFLKQVAVDESDKEKTIAFFQDSVSPLLQNFIQVLAYNHRANLFYDVLVDCLNRLE
                     KETNRFEVTITSAHPLTDEQKTRLLPLIEKKMSLKVRSVKEQIDESLIGGFVIFVNHK
                     TIDVSIKQQLKVVKENLK"
     gene            complement(20248..20742)
                     /gene="atpF"
                     /locus_tag="AC0DU4_001144"
     CDS             complement(20248..20742)
                     /gene="atpF"
                     /locus_tag="AC0DU4_001144"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0045259 - proton-transporting ATP
                     synthase complex [Evidence IEA];
                     GO_function: GO:0015078 - proton transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HIN4237110.1"
                     /translation="MHVTVGELIGNFILITGSFILLLVLIKKFAWSNITGIFEERAEK
                     IASDIDRAEEARQKAEVLAQKREDELAGSRKEAKTIIENAKETAEQSKANILADAKLE
                     AGHLKEKANQEIAQNKVEALQSVKGEVADLTISLAGKIISQNLDSHAHKALIDQYIDQ
                     LGEA"
     gene            complement(20756..21472)
                     /gene="atpB"
                     /locus_tag="AC0DU4_001145"
     CDS             complement(20756..21472)
                     /gene="atpB"
                     /locus_tag="AC0DU4_001145"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015078 - proton transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0015986 - proton motive force-driven ATP
                     synthesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HIN4237111.1"
                     /translation="MEESINPIISIGPVIFNLTMLAMTLLIVGVIFVFIYWASRNMTL
                     KPKGKQNVLEYVYDFVIGFTEPNIGSRYMKDYSLFFLCLFLFMVIANNLGLMTKLQTI
                     DGTNWWSSPTANLQYDLTLSFLVILLTHIESVRRRGFKKSIKSFMSPVFVIPMNILEE
                     FTNFLSLALRIFGNIFAGEVMTSLLLLLSHQAIYWYPVAFGANLAWTAFSVFISCIQA
                     YVFTLLTSVYLGNKINIEEE"
     gene            complement(21507..21707)
                     /locus_tag="AC0DU4_001146"
     CDS             complement(21507..21707)
                     /locus_tag="AC0DU4_001146"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit C"
                     /protein_id="HIN4237112.1"
                     /translation="MNLTFLGLCIACMGVSVGEGLLMNGLFKSVARQPDMLSEFRSLM
                     FLGVAFIEGTFFVTLVFSFIIK"
     gene            complement(21782..>22213)
                     /locus_tag="AC0DU4_001147"
     CDS             complement(21782..>22213)
                     /locus_tag="AC0DU4_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HIN4237113.1"
                     /translation="LLVLTDRKSRHQIIRLIPNKSAEVVNQALKLILKQHKILSITAD
                     NGTEFNRLFDVFSEEHIYYAHPYASWERGTNENHNRLIRRWLPKGTKKMTPKEVAFIE
                     KWINNYPKKCLDYKSPREDFWMANLNLKFSKMEIIFIKRFQ"
BASE COUNT         6617 a         4770 c         4057 g         6769 t
ORIGIN      
        1 actattgtat aatgcttttt gatttgagtc tagtattata ctcttcgaaa atctcttcaa
       61 accgcgtcag cttcgccttg tcgtatagat gttactgact tcgtcagttc tatctacaac
      121 ctaaaaacag tgttttgagc agtctgcagc taactttcta taacaaaatg aaataagaac
      181 aagacaaatc aatcaagaca atcaaatcga tttctaacaa tgttttagaa gtagatgtgt
      241 actattctag tttcaatata ttatagtttg ctctttgatt ttcattgagt attagttcaa
      301 tatctaaaaa aagaaccttg ccaagcaaga ttcttttagt gtctgactta aataattgtt
      361 cttctgggaa ctaaatcgaa ttaagcttcg atttctgtaa ccatacctga accaacagta
      421 cgtccaccct cacggataga gaatgtagta ccttgttcta cggcgattgg gtgaatcaac
      481 tcaacgtcga ttgtcacgtt atcaccaggc attaccattt cagtacctgc tggaagttcg
      541 attgaacctg taacgtcagt agtacggaag tagaattgtg gacggtagtt gttgaagaat
      601 ggagtgtgac gtccaccttc ttctttagta aggatgtaga cttcaccttt gaatttagtg
      661 tgtgggttga ttgaacctgg tttagcgata acttgtccac gttcgatttc atcacgttga
      721 acaccacgaa gaaggacacc tacgttatct ccagcaagac cttcgtcaag ttgtttacgg
      781 aacatttcaa caccagtaac aactgctttt tgagtttctt ctttgatacc aacgatttcg
      841 atttcgtcgt tgactttaac gataccacgg tcgatacgtc ctgaagcaac tgtaccacgt
      901 ccagtgattg agaatacgtc ctcgactgga agaagcaatg gtttgtcagt gtcacgttct
      961 ggttctggga tatactcatc aactgtgttc atcaattcca taacgatgtc ttcgtattta
     1021 gagtcacctt caagagcttt aagtgctgaa ccttggataa ctggaagatc gtcacctggg
     1081 aagtcgtatt ctgacaatag gtcacggatt tccatttcaa ccaattcaag caattcttcg
     1141 tcgtcaacca agtcaacttt gttcatgaag acgataaggt gtttaacacc aacctgacgt
     1201 gaaagaagga tgtgctcacg agtttgtggc attggtccgt cagttgaagc tactacaagg
     1261 atagctccgt ccatttgagc agcaccagtg atcatgtttt taacgtagtc cgcgtgtcct
     1321 ggagcgtcga tgtgagcgta gtgacgtttt tcagtttcgt actcaacgtg cgcagtgttg
     1381 atagtgatac cgcgttcgcg ttcttctgga gcagcatcga tagacgcata gtctttaggt
     1441 tggttaactg atgaaggcaa gcgacgtgcc aaaacagttg tgatagctgc agttagggta
     1501 gttttaccgt ggtcaacgtg tccgatagta ccaatgttaa cgtgtggttt actacgatcg
     1561 tatttttctt ttgccatttg agtaaaagcc tccaataaaa tatattttat agatagacag
     1621 taggcaatac agtctaactt tccttactat tttatcaaat ttcagctaaa ttgcaagtgt
     1681 tttacaacgt ttttgtgaat tattcttggt aaaaatttaa ctaattaata gaaagtacta
     1741 aatagactta tccttcaagg agttttcagc attatccatc cactcacttg ctgaaaatgt
     1801 aaacagtctc tggtttatat agtaaaatga aacaagaata gggcaaatcg atcaggacag
     1861 tcaaatcgat ttctaacaat gttttagaag tagatgtgta ctattctagt ttcaatctac
     1921 tatacaacct caaaactgtg ttttgaacaa cctgcggcta gcttcttagt ttgccctttg
     1981 attttcattg agtataaaat tgcagataaa acgataacaa tcataggact cagcagagtc
     2041 aatgtaggtc gaagaatagc ccccctaatc gcttatttta tagcaaaatg aaatagaaac
     2101 tgaacatttt gttgaggaag gtaaatcaat tcctcacaat gtttgagaaa gaagggggga
     2161 ctattccaac ttcaacccac tataaagcag acttacaaga tagggaaccc atctccgata
     2221 atattccgat aatatatagt agaatgaaaa ctgcacaatt tgattggaga attcaaacca
     2281 atttctaaca atgttttaga aacaagggtc tattatttca actgcaacct actatagccc
     2341 attgaagctg gaatagccca ctgagacttc taaaccactg ctggagagga gtttgtttag
     2401 agtttctttc atttccctaa aaaatcaaaa agagagaacc agtctgatcc tctcttactt
     2461 atagatggtg ctcactcaaa tgttaaagga gctatttctt agagataaag gaatttgaat
     2521 acagctactg ccgcaattgc tgctgcgata ggtgctacta ctggtaccca agaataccac
     2581 cattttgaat cgcctttatg ctcaccaaga actgattttg gaaggaaagc atgaaggaga
     2641 cgtggtccca agtcacgggc tgggttcaag gcaggtcctg taggtcctcc aagtgatgtt
     2701 accaaagcca taacgaggaa tccaagtgcc aagtgagcca cagaaagtcc tgaagcagtg
     2761 tgtggagcca cctgtgcttt aatagccaag tcagaaaaat caactgtttg tcctgcttct
     2821 attgcctttt gtttcatgaa ttgaagcact tcagcaccaa agaagttttt agtcaaacca
     2881 agagctgcaa agaacaaaac aaatgaacca acaaactcat taatcaaacc attgacagtt
     2941 gctgcatagc gactttcttt tgtaccatgg tcaatacttg aaatagttga gaaagttccc
     3001 aagatgttat ttgggttttc agttttcaag tagaatggac ggtatgttgc cacaactaag
     3061 gcttggccaa agatagcccc caagacttgc gcgataatgt aaggtaccac ttgtgcccaa
     3121 gggaaaagac cgctaactgc aagccctaga gtgaaagcag ggttgatgtg attcccagat
     3181 acgttaccaa acatcaaggc tgggatcata acccccatac cataaccaac agcgatgacg
     3241 atccagccac tttggtgacc tttcgtacct ttaagttcaa cgttggcaac tgcaccattc
     3301 ccaagaatga tcaaaatggc agttcccaaa aattcagtgg catacttcag tgcccatgtg
     3361 aaatccattt gctagattct ccttaaaatt ttttagatat tccttatttt atcaattttt
     3421 accctattta gcaactgatt tctggaaata tttttaaaaa aataggattc atagtttccc
     3481 agttcaacgg acttgtaagc gtttttattc ttcacgaaag acctcgttct caaaaccagg
     3541 aaaaaagccc acatctgtga gcttttcctg gttcctagat tctaaaatct attatttttc
     3601 atcttctttt ttcttgaaga atcctaatac tagactagct aacaaggtca tgataccagc
     3661 actagccaag gtagcattag cttctgtacc tgtgtttgac aatccctctc tcttacctgt
     3721 ctcataagtc ggaacttctg ggtctagatt cactggagtt tcagtttttg gagtacctgg
     3781 ttctggagtt ggctctggta ttggagtctc ttgatttggt agttctgggt ttggtgtcgg
     3841 aacacttgga tgctctggat ttggttgtgg gattggtttt tctggagttg gtttatctgg
     3901 tgttgataaa cggtcatacc ttaccgttat ttctttatca ctagagtctg acgtaacttc
     3961 ttgtgattca actgttggaa tatctggagc tttgtacttg tcaatcttac cagatacaac
     4021 ctcgtcccag tttcctgttg tccattcacc gtaggttaca actcccgtga ccttgttctc
     4081 agtttttgta cggcttaagg ttacaggttg aacaacatct tcttttacat tttggttcgt
     4141 aactttatca acgtaatgaa tgatacgcgt tatagtcttc gtctcagtag aggttgctgt
     4201 tttgggaacc actgtttcct caacattcta acggtagtaa tagtcaactg ttgcaccgtc
     4261 ttctggtacg catttgcagg agttgctacc aaggtgtatg ttgttttcct tgtgataact
     4321 cggttttctt tgtcctcagt tgttgttttc ccttcaatag tttttgattc tgtggtatac
     4381 tcagaaccta tcgctaaatc agcttttata acagactctg ccaacttctc ttggctacct
     4441 tctttatagt aattggctgt tactgtaaca gtggttggcg cttcgctttc tctataaact
     4501 aaggtcactg ttctaccttc gcttacaata ttcccagtta aacttgcaga atttgtatct
     4561 acttctttaa aagtataata ttttccgtca gtagtagtca tgctactgag ttttttatct
     4621 gtgacattgt agctggtacc aatcagttgt tttttattgg taatgtaggt tccgtcactt
     4681 tctttttctc caattccagt atcatttttc aatgatagca aacgcccttg ttcatcaaca
     4741 tagcgaactt tcacattttc tgagattagt tctgccaatt ctgaggtttt tttctttttc
     4801 ttgatttctt cggttatttt ccctttctct tcttcgggaa tatttagttt tggaatgatt
     4861 ttttcaacaa cggttcgtga tggttccaca gtatcttgga tgactgaaaa gtcagctaga
     4921 attgggagat tatactgaac acggtgactt tgagtgttta ctcctactct ttcattattc
     4981 tctgaaaata cttgtacggt ataagaaaca acatcttttc ctaatagaac atccccagta
     5041 gagaaatagc cgccttttcc tagtttgcta tctccagagc ccacttcttt cctaatctta
     5101 tcagatagtt ttttaccagt cagtacattc gttcgcacaa tccctttgtc tacccctaca
     5161 aagtgggaga actttttgaa ctcttcagaa ccagatctag cccaaccatt attaagggca
     5221 tttgcttttg tatttgtatt ctctctcaaa agtttggcga ttagaattat attcatcggc
     5281 acttagagtt gctgctatat ctgactcttg aataccaact tccttactac catttctagc
     5341 ggcagtatat gtgtatttat ctgtttctac ttctagctga ttatccttaa catgataggt
     5401 aattttctcc tggtataaga gtcttcagta gtttatatgc tctgtcatca tctttagctt
     5461 tagaagcagc tgagtttagc caagttgggg tattaggagt atctttatca gcctgtttca
     5521 agacattatt caagtcattt gctagcctat tggttgtcct cactgtgaaa gttttcttcc
     5581 agtctgaacc acttttatta gacttagata tgctcatgaa atcctggtca acattcaaca
     5641 caatatcgcc ttgtttttta gcatcttccg ttgcttctgc ttcaaattga tcatggagtt
     5701 tttgttgctc tggtgtatag tttttttatt tacacgattt aatgtactat tttttatttt
     5761 agtattaaga actccattaa tacgattttt aaactctgct tcaaaaaatc ccttaatttg
     5821 ttggtgcgca agttcaacat tcaaaccttt tttatacaag tcttcattct gaacgatttc
     5881 ggctacacgg tgaatggttt gattgtatac cgtcttctct taaccagcag tatccttagt
     5941 tttaatgact actcgatagg ttcctttaga accgttatag tcatctagtt ttaaaaaagc
     6001 attccaaaca ttcaaaaata gttggaactt cccttaataa atccgtcact ttctttttca
     6061 agatagccca agcttgctca ataggattca aatccggtga ataaggtggt agaggtaaga
     6121 aaaagtgttt atcttggatg cagagttcat ccaaaatgtt cttgggatga aaaccagcat
     6181 tgcccatgac aataacatga ggtgtcttca aagcaggtag gagttgcgtt ttgaaccact
     6241 ccacaaagaa atcgcttgtc atgcttttct tgtaaatcat gggagctata aactctccgt
     6301 ctacttgtcc tgcaacaatt gaaattcgct caaaacgacg tccgctaatc ttttcataga
     6361 ctttctcccc tctaggagcc cctgcataag gacgatagag atagcggtcg attcctgttt
     6421 catcaatata aacaggtgct aggtgcttta aactattaaa attcttaaga aataaggcta
     6481 cttttctggg tcttgttcct taaagctcgt catctttttt taaagtgacc ttaatctgct
     6541 ttaaagctgc ccatactgaa ggaacagcac aatcaaaatg tgccgcaatt tcccgtaaaa
     6601 aagcatctgg atgagcctct acaaaggctt tcaattcctc taaaggaatc tttcggtttt
     6661 tgacgactcg ctttttcctc tctatgtgtt cttgttcacg tctttctttt cccacgtgaa
     6721 gagagttctg acgccaacac caaaaaactt ggctgcctcg acatggctgt gcccctcttt
     6781 gatgtaatct aatgctcgct gtttaaaatc agtactatat gccatagctt tattataata
     6841 tgcttgttta aaactaagta actatatcaa tgttttgtta tgagaagact tacttttttt
     6901 actgaaattg aatttttcct agcctaaaca tcatataacc ccaaaattca atctgacctg
     6961 gtttgaagag attttcgaag cagataaggt tttactaaaa ctaaaaaaaa tgatataatc
     7021 aaactgatta aatgttttaa aaataaagga gaatttgaat gtcttaccaa gaaaattacc
     7081 agaaatgggt tgattttgtg gagcttcctg actaccttcg tcaagatttg gaaaatatgg
     7141 acgaaaaaac taaggaagat gccttctata caaatcttga atttggtact gcaggtatgc
     7201 gtggcttggt tggtgctggt acaaaccgta tcaacatcta cgttgttcgc caagctactg
     7261 aaggattggc tcgtttgatt gagtcaaaag gtggaaacga gaaagaacgc ggtgtagcaa
     7321 ttgcctacga tagccgtcac ttctcacctg agtttgcctt tgaatctgcg gcagttcttg
     7381 ctaaacacgg catcaaatct tacgtatttg aaagccttcg tccaactcca gaactatcat
     7441 ttgcagttcg tcatctcaac tgtttcgcag gtatcatggt cacagccagc cacaaccctg
     7501 ctccatttaa cggttacaag gtttacggtg aagacggtgg acaaatgcct ccacacgatg
     7561 cggacgcttt gactacttat atccgtgcaa tcgaaaaccc atttgcagtt gaagttgctg
     7621 atgtggaaac tgaaaaagct tctggcttga ttgaagttat cggcgaagct gttgacatag
     7681 aataccttaa agaggttaag gacataaaca tcaacccagc cttgattgaa gaatttggta
     7741 aagacatgaa gattgtctac acaccacttc atggtactgg tgaaatgttg gctcgtcgtg
     7801 ctcttgccca agcaggattt gactctgttc aagttgttga agcgcaagca actgctgacc
     7861 cagacttctc aactgtaaca tctccaaacc cagaaagcca agcagccttt gcccttgctg
     7921 aagaacttgg tcgtcaagtt ggtgcagatg ttcttgtcgc aactgaccca gacgctgacc
     7981 gtgttggtgt tgaagttctt caaaaagatg gtagctacct caacctttca ggtaaccaaa
     8041 tcggtgctat catggctaaa tacatcttgg aagctcacaa aaacgccgga actcttcctg
     8101 aaaatgccgc tctctgcaaa tctatcgttt caactgactt ggtaacgaag attgctgaaa
     8161 gctacggcgc aactatgttc aacgtcttga caggtttcaa atttatcgct gaaaaaatcc
     8221 aagaattcga agaaaaacac aaccacactt acatgatggg atttgaagaa agcttcggtt
     8281 acttgattaa accatttgta cgtgataaag atgccatcca agccgttctt gtcgttgctg
     8341 aacttgctgc ctactaccgt tctcgtggtt tgacacttgc tgacggtatc gaagaaatct
     8401 ataaagaata tggctactac gcagaaaaaa caatctctgt tactctttca ggtgtcgatg
     8461 gtgctgaaca aatcaaagcg attatggcta aattccgcaa caatgctcca acagaatgga
     8521 acgcaacagc tatcactgtc gtagaagact tcaaggcaca aactgctact gttgctgacg
     8581 gtactgttac aaacttgaca actcctccaa gtgatgtgtt gaaatacaca cttgctgacg
     8641 gttcatggat tgccgttcgc ccttcaggta cagaaccaaa aatcaagttc tacattgcag
     8701 ttgtagggga aaccaacgaa gaatcacaag ctaagattgc taacatcgaa gcagaaatca
     8761 atgcatttgt aaaataaaga cctataaaag atgagaccaa ccaacctcat cttttttcgt
     8821 atcaaatcta agcaatttta gaaactttat ggcatactag acttatcaat gaaagcgagg
     8881 taatctcatg gaacaatttt tagataacat caaagacctt gaagtcacta cagttgtgcg
     8941 tgcgcaagaa gctcttgata aaaaagaaac tgcaaccttc tttatcggtc gcaaaacttg
     9001 cccttactgc cgtaaatttg caggtacatt gtcaggtgtc gtagctgaaa ccaaagctca
     9061 catttacttc atcaatagtg aagaaccaag ccaactcaat gatttgcaag cattccgctc
     9121 acgttatgga atcccaactg taccaggttt tattcatatt acagatggac aaatcaacgt
     9181 ccgttgcgac tcttcaatgt cagcacaaga aatcaaagat ttcgcaggat tgtaaaaaat
     9241 cagctaacaa gtcttaaaat cacaaaaacg cataatgtaa ggtgcaaaaa ccttgatatt
     9301 atgcgtttta ttgttcctaa aacagttaca tcagtatttc attacagaac attttaattt
     9361 tggaagtcaa atcaattttt aacaatgttt tagaaatcac agtgggctat tccatattca
     9421 attatccaga ttcaatcgct attatcgttt tcctagatta caaaaaaaac tacgttttgc
     9481 taatcaaaac gtagtctcag ccactatttt atcttactgt ccttctttta cttctttggt
     9541 tgctacatct tctccaaacc atttttggct gatttcttgg aacttgccgt ccttgtaaag
     9601 actagaaaaa gcttcattta tcttcttaac caaggttgta tcttccttac gggctccaac
     9661 cgcaaaagct tctgtttcta gtccaactgt aaagacatta taatcgttta aaacaccttc
     9721 tgcttctaaa taatagtttg cataaacacg gtcaatcaat agaccatcaa ttcgatcgtt
     9781 tttcaaatca atcaaggctt cattaaaggt ttggtattga ttcgcttcct tattagcgac
     9841 aatattcttc aaaagttctg gatttgcttc aaagtccgca taaccagatg aaccagcttg
     9901 agctcctaat gtctttccag tcatatcctt tgcagtcgtg ataccagata atttcttcgt
     9961 aaccaatacc tgctcattct tcatatatga gttactgaaa gccacctttt cacggcgttc
    10021 gtctgtagcg gaatagccat tccaaatcag atcaatcgtt ccttttgtca attcagcttc
    10081 tttcaaatcc caatcaatcg gttgccaatt taccgtgatt ccgtattttt caaaaacagc
    10141 tgtagctaaa tcaatatcaa atcctgcata agaaccatct ttctgagcaa atcccattgg
    10201 aacaaaagta ctatcaaatc caatagtaat agacttgtta gactggtact ttgaccaatt
    10261 atctccacta gtttcgctag aatttttccc acaagctact aagaacaaag cagtcatcag
    10321 actgactaat acaagcatcc attttttcat ccatttttcc tcctatttag gttctacttt
    10381 caataataca tctgcgatat tttcagcaaa ctgcaaatca tgggtaacca caatctgggt
    10441 catcccaagt tccctatttt gcaagattag cttctccact tccaaacgta attctggatc
    10501 cagggcagaa gttggttcat cgtagccaat gatttctggg tcaatcatca tagcacgcgc
    10561 caaagccact cgctgctttt gcccaccaga tagtgagaaa ggataggcct ctgcgtgtcc
    10621 tcctagtcct aactgttcca agagttcact cgccttcttc tcagcctctt cctgcttcat
    10681 tcccatggtc ttcacaggcg ataaagtcaa attttccaga actgatagat gaggaaatag
    10741 ttgaaaatct tggaagacaa atcccagtag gttgcgcttc tgcaattcat ccagctctaa
    10801 aggttgtcca ttataaaaga tttgccctga atcaatggtt tcaagacctg caagcatacg
    10861 taaaagagtt gtcttacctc caccagaagg tccaacgata gccaggattt gcttttcagg
    10921 aatatttaga ctgaaattag acaggatttg tttgtctcca aagactttat tgatatttcg
    10981 taattctaac atggcagcct cctatctata ataactatac ttcttctcaa cttttttgga
    11041 aataattgtc acaatcccaa tcaaaatcaa ataaatggct cctgccaaga acataggaac
    11101 cagactagca tcgcggttag cagctgttcg actagccaag ataaggtctg aaattccgag
    11161 agcatagacc aaagaagtat ccttgaccaa actcataact tcattaaaga cactaggaag
    11221 aacgatcttg gtcacttggg gcaagataat atagcgcact ctgtcaaaag ggctaaactt
    11281 caagaccttg gcagcctcat actgtcctct tggaatagtg tcaattcccc cacggaaaat
    11341 ttctgcaaag taagccgcat aattcaaaac aaaggcaata atagctgcag gaaggcggtc
    11401 taaacgaatc ccaatacttg ggagcacata atagataaaa atcagttgca agagtaaggg
    11461 ggttcctcgc ataacccaga tgtaaatgtt aatcagataa tggaggggct tccaatggac
    11521 ttgcaaggca aaggcaatca aaacgcccaa gggaatcgaa aatagcaaga ccagtgcaaa
    11581 gacctgtaca gtcgtgctcg caccattcag taaactcggt aatatctcaa ataaataaga
    11641 catactgcac ctcctaaaag taattgttcc tattatagca tgaataaaca agattaccaa
    11701 gtatttttgt aaaaagattc taccatatac aaataaaaac cgtagctatc aaaagagata
    11761 aactacagtt ctatatgttt aaacattctt acaatctctc aaacagttct tgcatttgca
    11821 catcatctgg aaccagtttt aagtaagtgt gagcatggac ttttgcttct tcaaaatgtc
    11881 ccaattcacg caagagatag atatagtgtt ccagaaattc tggattgtcc ttcaaatctc
    11941 ctgtcaactc ttgataatgc tcataagcag tatccaaatc gtccatttct tgataagaac
    12001 gagcaatcat ccacttggtc aaaagatttt ctggctcctc actctgcaag tctagaatat
    12061 cctcataacg ctcctgctcc agataaatag tggctaaacg aagcaagatt tcttctgtat
    12121 cctcagcgtc ttcttttgca gtaaggagat aattttctgc accactagca tcatgcaatt
    12181 cataagaaaa ttgtgaagca gctagcaaga ggcgagtttc aaagggattt ttctctaatc
    12241 cttgcttagc gatacgcagg gcttcttgaa cttgatgttc cttatgtaaa gcctgactgt
    12301 acccatactc atagccttca aagtcaggag aaatggtatc aagctgctta aagtagaggg
    12361 tggctttttg atattcttct tgatcaaaat aaagactggc caactcaaaa gctgttaagt
    12421 catcgtattc taactccagg gctttttcta aaaactcagt agccgtttca aatttcccta
    12481 actgagcata ggcaaagcca attcgttgat aggtggaaat gcccgtttgc tcataaatcg
    12541 agcgattatc taactgggca taggcttgaa tagccgcttg gtaattttcc aactcactat
    12601 ccaactctgc caaacccaat atcaagagag aatcctctga gtaggtcaag gcctccaata
    12661 atttctcacg tgccacatct gtcaaacctt ccagctggta aaggtctgcc ttcagagcca
    12721 aagacgagac ataccagtca ctgtcagctt ggatttcctc aagataggta aaggcttctt
    12781 ctatttgacc atcctcgcta gcaattgcag ctagattaag atgaacctct ggaaaatcct
    12841 ctacaatttt caggtaaatt tccttggcct gaggatagaa accaatccct tcaagataag
    12901 ttgccaactc atacagaaga tcacttgaat cattttctaa agctttggcg aaataatgct
    12961 cagccttagt taaatcttgc tcctccaaag cctgtaacat ctgttgacta ttgttcactc
    13021 ttgacttcct caccctctaa ttcatataga ccactgacta ccttatacca ttcgaaaatg
    13081 gctgaaatga caaccttagc agaggcataa accggaatac caagtaaaac tccccagata
    13141 ccaaacatag atcctgaagt taacaaaaca aagagaacat taataggatg gatgtttaat
    13201 tgacttccca aaatcaatgg agagacaaaa cggccttcaa tagtttgttc tacaataaag
    13261 acaatcacta ctttcaaaag catgactgga ccagcaatca aacccaatac tagggcagga
    13321 agcatggcta gaaagctacc aagataaggg accagattta aaataccagc agtaaccccc
    13381 agcgtaaccg catagcgtag accaataatc ttgaagaaga tgataaacat tactgctaca
    13441 ataatagcca ctgtcacttg ccctcgaaca tagttggaca actgttgatt cacatctgat
    13501 agaacttgtc caacaggttc cttcaatttt cttggaatga attgggtcaa atagttacgc
    13561 aagcctttcc catcacgcaa gagataaaag agcatgaaag gaacgataat caaggcaaca
    13621 atcacttgag aagctccgct aataaaggca ctcacccagt tgactgcctg agatgaaacc
    13681 ttacttgcca aaactgtagc ctggctagaa aaattggtca aaacttgctc taattgaggt
    13741 ctgaaatcat ctggcaggtg ctgggctacc aatccattaa caatcctatc tatatcttct
    13801 aagtaaacag gaacgtttct tgcaaaggtc aaaacctgac gttgcagatt tggaatggcg
    13861 actgccaagc cccaaatgat aaagagagcg atgataacaa agacaatagt gatagctata
    13921 acacgattaa ccttatgctt ctccatccaa tcaacaatag gattcaacaa ataatataac
    13981 aaaccagaca aaatgactgg caacatcaca actgctataa agtctaaaac aggtgaaaat
    14041 agaaaactaa tcttacttaa aataaaaaga ttcaatccca ataataaggt tactaaaaat
    14101 accgtaattg ccttgttatc taaaaaccac ttgaaaaacc aagataggct aaaatgtttc
    14161 tctttttgct ccataaatac ttcctttcta ttgttctctc attataccat ttttgaaaca
    14221 aaataactct tttttaaagt gcttacatct aattgaatgt ctttaatttg cttgtttttg
    14281 tgatataata gtcttatctt tacacagagg tatagtaatg aaagaaactg tttattttgg
    14341 aacttataca cgtcgtactt ctcaagggat ttacaaggca gactttgata cagaaactgg
    14401 tcagctttca aatctagaac tttttgcagc tgagccaagt ccaacctacc ttgcctttga
    14461 ccagcaccaa catttataca ctgttggtag ccaagacgat aaggggggaa ttgcagccta
    14521 tcaaactgac gggactgtgt taaatcatgt tgttgaagaa ggagctcccc actgttatgt
    14581 tgctgtcgat gaaaagcgtg atttggttta cgcagccaac tatcacaagg gacaagtcct
    14641 tgtttataaa cgccaggaag atggtagtct tctacttagt gatatggatc aacacagtgg
    14701 ccaaggtcca catgaaaatc aagcttcccc ccatgttcac tatacagatt taacacctga
    14761 ccactatcta gtgacctgcg acttgggaac tgaccaagtc atcacctatg acctcgatca
    14821 agaaggaaaa ttatctaagc tctataccta tcacagcaag ccaggagcag gctcacgcca
    14881 tatcattttc cataaccact ataaaatcgc ttatctcatt tgtgaactca atagtactat
    14941 cgaagtttta atctacgatg gcgttggcga atttgaacgt atgcaggtta tttcaacttt
    15001 accagaagct tacgaaggct ttaatggaac cgctgctatt catctctcta aagacggtaa
    15061 atacctctac gcttctaacc gtggccatga ttctatcgca gtatatacca tccttgcgga
    15121 cggtagctta gagttattag aaatcgttcc aacgcatggt cagactccac gtgattttga
    15181 tttgacaccc gaccaaaaat ttctcattgt tgtccatcaa gactctgaca atgcaactgt
    15241 ctttaaacgt aattgtgaca atggtcgtct agcagaactc tccaacgact tccatgttcc
    15301 cgaagcagtc tgcatccgtt ttgctcctta aaacaccata aaaaatgaac ttggtatttt
    15361 caagttcatt ttttcttata gtctatttcc gacattaata cggttaatag cacgttgcaa
    15421 agcaatctta gcacgacgtt cttggtcaat caaatgtttg tcttgtgctt cttcaattgc
    15481 acgttctgca cgaagtttgg cacgttctgc acgactgata tcgatatcac gagcacgttc
    15541 tgcagagtca gcgacgattg tgatcatatc attggcaatt tcaataacgc caccgtttac
    15601 tgcaatccag ttcacgtgat ctttatcatc gatacgtttt acctttactt catcaactgc
    15661 taaaaccgca atcatatttt catgtcgtgg caagatcccc atctcaccat ccagagttcg
    15721 aaccgataca tagctggcat ggtgatcata gacgagacca tctggtgtca cgatctggac
    15781 agttaactga gccatagatc acctcttaaa atcccatttt ttcagctttt gcaatcacat
    15841 cttcgataga acctacacca cggaaggcat cttctggcaa gtggtcgtat ttaccatcaa
    15901 ggatttcctt aaagccacgt acagtttcag caactggaac ataagaacct ggctgaccag
    15961 taaattgttc cgcaacgttg aagttttgtg acaagaagaa ctggatacga cgggcgcgag
    16021 caaccaaggt cttttcttca tcagaaagct catccatacc aaggatagca atgatatctt
    16081 gcaattcatg gtaacgttga aggacacgtt ttacttcagc agcaactgca tagtgctctt
    16141 ctccaacgat ttcaggtgcc aaggcacgtg agcttgaagc aagtgggtca acggctgggt
    16201 agatacccaa ttgtaccaac ttacgttcca agtttgttgt tgaatccaag tgagcgaagg
    16261 ctgttgctgg cgctgggtca gtatagtcat ccgctggcac atagatagcc tggatagagg
    16321 ttacagaacc cttcttggtt gatgtgatac gttcttgcaa ttgacccatt tccgtagcaa
    16381 gtgttggttg gtaaccaacg gctgatggca tacgacccaa aagggcagat acttctgaac
    16441 cagcctgagt gaaacggaag atattatcga taaagagaag cacgtcttgg ccttccacat
    16501 cacggaagta ttcagcgatt gtcaaaccag taagggcaac acgcatacgt gctcctggtg
    16561 gctcattcat ctgaccaaag accatggctg ttttctcgat aacgcctgat tctttcattt
    16621 cccagtaaag gtcattcccc tcacgagtac gttccccaac accagtaaat actgaaatac
    16681 caccgtgctc ttgggcaatg ttgtgaatca attcttggat taagacggtt ttaccaactc
    16741 cggcaccacc gaaaagtcca actttaccac ctttaaggta aggggcaaga aggtcaataa
    16801 ccttgatccc tgtttcaagg atttcagaag aggtagacaa ctcatcaaaa gttggagctt
    16861 ttttatgaat tggctgacgc tctgcgtctt ctgtaaaagg agcttccaaa tcaatggtat
    16921 ctcccaaaac gttgaagaca cgtcccaaag tttctttacc tactggtaca gagattggac
    16981 gacctgtgtc caatacttcc attccacgag tcaacccatc tgttgattcc atggcgatag
    17041 tacgaaccat accatctcct aactccaagg ctacttcaag gacgattttt gtttttcttt
    17101 cgtcattttt gtagacgaca agtgcattgt taatctcagg aagtttttcc cctgctgcaa
    17161 acaaaacgtc tacaacggga ccgataacct gagcaatttt acctgaactc atctccttct
    17221 cctattctat ataagatact gtcggttcct agctcaacta ggtcctaagt tcattttcat
    17281 acgagctgga ctagagccta ttctaaggca ctagcacctg ctacgatttc tgtaatttct
    17341 tgtgtaatcg ccgcctgtct ggcacggtta tactgaattg tcaaatcatt gatgactttc
    17401 ttagcattat ctgtcgctgt ttgcatggct gtcatacccg cagcattctc agctgtcttg
    17461 gcatcgataa tggcaccgta aatcatactt tctgcaaact gaggcaacaa ctgctccaga
    17521 atttcttctc ggctggtttc caattcaaaa gtcaagctgt actcttcatc cgcttcattt
    17581 ggatccaagt caacaatcgg aagcatttgt tccacacgca tttgactggt tagcgtattg
    17641 acatggtggt tgtagcaaac ataaagctca tcaaagagtt cattttggta catttcaaca
    17701 gtttttgaaa taatcttacg aacttgatca aagctaggtt ggtctgccaa gccacgtaat
    17761 tcataaagtg gttgaatacc gcgagcctta aagaaatcag ctcccatccc accgatacag
    17821 atcatttcaa aacctttacc gtctgggtgg tattcttctt tcaactccat aacagctttc
    17881 aaaatagagg aattataacc tccaaccaaa ccgcggtctg aagtgataac gatatagcct
    17941 gtcttcttca cagaacggct aatcaacatc ggattagttg aagcaccagc tccattacca
    18001 tgaaggatat ctgtcaaaag tttacgcact ttctgagcgt aaacttggaa gttgcgagca
    18061 gcttcttcag agcgacctaa cttagcagcc gataccattt gcatggcatt agtgatttga
    18121 ctcgtatttt ttgttgaggc gatttttgtt ttaatatcat ttagagacac tgccatctga
    18181 cacctctatt cttattggaa gctagattga ttgagaaact ctgtaatcgc agcatccaag
    18241 actgcttctt ctggcaagtc ttttgtatca cgaatggttt ccaaaatctc tggatgttga
    18301 gcatcaaaga aggcatggaa ctcttcctcg aaacgaacaa tatcatctac tggaacagta
    18361 tccaagaaac catgtgtcaa agcataaaga atggttactt gtttctcaac aggtaatggt
    18421 ttgtgaacag gttgtttcaa gacctcaacg gtacgacgtc cacggttcaa cttagcctgt
    18481 gttgctgcgt ccaagtcaga accaaactta gtaaaggctt ccaactcacg gtatgaagca
    18541 aggtcgatac gaagtgtacc agcaaccttc ttcatggctt tgatttgtgc agaaccacct
    18601 acacgagata cagatgaacc cgcatcgatg gctggacgaa tacctgcatt gaagaggcca
    18661 tcgccaagga agatttgtcc atcagtgata gaaatcacgt tggttgcgat ataggctgag
    18721 atatctcctg cttgtgtctc gataaatggt agggctgtaa ttgatccacc accaagttca
    18781 tcagaaactt tagctgagcg ctcaagcaaa cggctgtgga gatagaaaac atcccctggg
    18841 aaggcttcac gacctggagg acgacgaagc aagagcgata gttcacgata agctaccgct
    18901 tgttttgata gatcatcgta tacaatcaaa acatgcttac cttgatacat aaattcttcc
    18961 gccatagcaa ccccagtata aggagctagg aagagcaatg gagatggttg tgaagcagag
    19021 gctgtcacaa cgattgtgta gtccaaggca ccgtactgac gaagtgtttc tacttgcgta
    19081 cgaactgttg attctttttg tccaatcgcg acgtagatac agatcatatc ttgatctttt
    19141 tggttcaaga ttgtatcaat cgcaatggtt gttttccctg tctgacggtc accgataatc
    19201 aactcacgtt gaccacgacc aatcggtaca agggcgtcaa tagctttcaa accagtttgc
    19261 aatggttctg aaacagactt acgttgcata acaccaggag ctggtgcttc tactggacga
    19321 gttttatcag tgtggatttc tccaagaccg tcaactggac gaccaagcgg atccacaaca
    19381 cgaccaatca gactttcacc tacagggact tccatgattt tccctgtacg gcggattgta
    19441 tcgccttcac ggatatctgt aaagtcacct aggatgataa taccaacgtc tgttgactcc
    19501 aagttttgag ccataccata agagccgttt tcaaaattca acaactctcc actcatgaca
    19561 ttttcaaggc catgagcacg cgcgataccg tccccgatat aggttacaac acctgtttca
    19621 gtcacatcaa aattgggttt gaaattttca atttgttgct taattaaagc gctgatttct
    19681 tgtgcgttaa ttgccaaaag aacaccactt tctatttcaa attttcttta acaactttaa
    19741 gttgttgttt aatactcaca tcaattgtct tgtgattgac aaaaatgaca aaaccaccaa
    19801 tgagactttc atcgatttgt tcttttacac tccttacttt cagagacatt tttttctcaa
    19861 tcaaagggag caaacgagtc ttctgttcat cagttagagg atgagcagac gtaatcgtca
    19921 cttcaaatcg atttgtttct ttttcaagtc ggttcaagca atctacaagc acatcataaa
    19981 aaagatttgc tctgtgattg taggccagaa cctggataaa gttttgtaat aaaggcgaca
    20041 cagaatcttg gaaaaaagca attgtttttt ccttatccga ctcgtctact gccacttgtt
    20101 ttaaaaaaga aggcagacct gttttttcaa caacttgctt gatttgagtc aagtctgaaa
    20161 agatacggtc ttcttctcct ttttcaagta ccaattggac aaaaggcatg ctgtattttt
    20221 caattacctt tactgttttc ttgtccatta agcttctcct agctgatcga tatactgatc
    20281 aatgagtgct ttatgggcat gactgtcaag gttttgtgag atgattttac cagctaagct
    20341 gatggtcaaa tctgcgacct cacccttaac actctgtaaa gcttctactt tattttgagc
    20401 aatttcttga ttggcttttt cttttaagtg tcctgcttct agtttagcat ctgctaagat
    20461 attagcctta ctttgctcag ctgtttcctt tgcattttca atgattgtct tagcttcttt
    20521 acggctacca gccaattcat cttcgcgttt ttgagccaat acttctgctt tttgacgggc
    20581 ttcttcagct ctgtcaatat ctgaagcaat tttttcagct ctttcttcga aaatgcctgt
    20641 aatattagac catgcaaatt ttttaatcaa gactagcaaa agaataaaag agccagtgat
    20701 taaaataaaa ttaccaatta attcacctac tgttacgtgc atcagttact cctttctatt
    20761 cctcttcaat attaatctta ttccctaaat acacagatgt caaaagagta aaaacataag
    20821 cttggatgca ggaaataaag acagaaaatg cagtccaagc caaattagct ccaaaggcta
    20881 ctggatacca ataaatagct tggtgggaaa gaagaagtaa caaactcgtc atgacctctc
    20941 ctgcaaagat attcccaaaa atccgcaaag ccaaagataa gaagtttgta aattcttcca
    21001 agatattcat cggtatgaca aaaacaggac tcataaaaga ttttatactt tttttaaatc
    21061 cacgacgacg aacgctttct atatgtgtca acaaaatgac aagaaaagat aaggttaagt
    21121 catactgtaa attagcggtt ggcgaactcc accagttagt cccatcgatc gtttgaagct
    21181 ttgtcattaa gccaaggtta ttggcaatca ccatgaaaag gaataaacaa aggaaaaaga
    21241 gtgagtaatc tttcatgtag cgcgaaccaa tgttaggttc tgtaaatcca ataacaaagt
    21301 catagacata ctcaagtaca ttttgctttc ctttgggttt caaggtcata ttgcggcttg
    21361 cccaataaat aaagacaaaa ataactccca caatcaacaa agtcatggct aacatagtca
    21421 gattgaagat aacaggacca atagagatga ttggattaat actttcttcc atctaaaatc
    21481 ctcccttttc ttctcgttcc atgtatttat ttgataataa atgagaagac aagagttaca
    21541 aagaaagttc cttcaataaa ggcaacacct aaaaacatca aactacgaaa ctcagaaagc
    21601 atatctggtt ggcgtgctac tgatttaaac agtccattca tcaataaacc ttcaccgaca
    21661 gatacgccca tacaggcaat acataagcct aaaaatgtta aattcataac aaattctcct
    21721 ttaaaataaa atttacttac ttagtgtagt cctaaaattt aaatttgtca acttttaacc
    21781 gctattggaa gcgtttaata aaaattattt ccattttgct aaatttcaag ttcaagttag
    21841 ccatccagaa gtcttctctg ggtgacttgt agtccaagca ttttttagga tagttgttaa
    21901 tccacttttc gatgaatgcg acttctttgg gagtcatttt cttggttccc ttaggtaacc
    21961 atctacgaat gagcctgttg tgattctcat tagttcccct ttcccaagag gcataggggt
    22021 gcgcataata gatgtgctcc tcagaaaata catcaaacaa gcgattgaat tccgttccat
    22081 tatctgccgt gatggaaaga atcttgtgtt gttttaagat gagttttaga gcctgattga
    22141 ccacctcagc acttttattt ggaatcaatc ggatgatctg atgtctactc tttcgatccg
    22201 tcaagacaag caa
//
LOCUS       DBMVGT010000027        21320 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.027, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000027 DBMVGT010000000
VERSION     DBMVGT010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 21320)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21320)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21320
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.027"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            38..358
                     /locus_tag="AC0DU4_001148"
                     /pseudo
     CDS             38..358
                     /locus_tag="AC0DU4_001148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884744.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
     gene            479..1423
                     /gene="manA"
                     /locus_tag="AC0DU4_001149"
     CDS             479..1423
                     /gene="manA"
                     /locus_tag="AC0DU4_001149"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004476 - mannose-6-phosphate isomerase
                     activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HIN4237114.1"
                     /translation="MSEPLFLQSVMQEKIWGGAKLRDEFGYDIPSEKIGEYWAISAHP
                     NGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAY
                     GLEHEGELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDALLTKVPVKAG
                     DFFYVPSGTMHAIGAGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNI
                     GEPANSRPVTIKADDLRSTLLVSNDFFAVYKWEITGKVNFEKTADYSLLSVLAGQGQL
                     TVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP"
     gene            complement(1444..2712)
                     /locus_tag="AC0DU4_001150"
     CDS             complement(1444..2712)
                     /locus_tag="AC0DU4_001150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-dependent transporter"
                     /protein_id="HIN4237115.1"
                     /translation="MTAANGDGGFLLIFLISTILIGFPLLLAEFALGRSAGVSAIKTF
                     GKLGKNNKYNFIGWIGAFALFILLSFYSVIGGWILVYLGIEFGKLFQLGGTGDYAQLF
                     TSIISNPAIALGAQAAFILLNIFIVSRGVQKGIERASKVMMPLLFIIFVVIIGRSLSL
                     PNAMEGVLYFLKPDFSKLTSAGLLYALGQSFFALSLGVTVMLTYASYLDKKTNLVQSG
                     ISIVAMNISISIMAGLAIFQARSPFNIQSEGGPSLLFIVLPQLFDKMPFGTIFYVLFL
                     LLFLFAPVTFSVVMLEINVGNITNQDNSKRAKWSVILGILTFVFGIPSALSYGVMADV
                     HIFGKTFFDAMDFLVSNLLMPFGALCLSLFTGYIFKKALVMEELHLDERAWKQVLFQV
                     WLFLLRFFVSSFQSSSWSSSPNLCNQKGLE"
     gene            complement(2709..2930)
                     /locus_tag="AC0DU4_001151"
     CDS             complement(2709..2930)
                     /locus_tag="AC0DU4_001151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-dependent transporter"
                     /protein_id="HIN4237116.1"
                     /translation="MIFLTDLRKHDRIVKSINQTEGYLTTQVAFSYFEKGDQSLTMSE
                     KSQWGSKLGFILASAGWPSGLVPFGSFPT"
     gene            3035..3784
                     /locus_tag="AC0DU4_001152"
     CDS             3035..3784
                     /locus_tag="AC0DU4_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000274794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HIN4237117.1"
                     /translation="MYHIKEAAQLSGVSVKTLHHYDKIGLLVPLKSENGYRTYSQEDL
                     ERLQVILYYKYLGFSLEKIAELLKEERTDLLPHLTRQLDYLTRERQHLDTLISTLQKT
                     IQEQKGERKMTIEEKFTGFSYQDNQKYHQEAVEKYGQEVMGQALERQKGHEDEATAAF
                     NQVFQTLAQNLQVGLPATATENQEQAAKLLQAIRTYGFDCSIEVFGHIGKGYVYNPEF
                     KENIDKFGSGTAQYTSDAIAAYVQTNAEKIG"
     gene            complement(3804..4259)
                     /locus_tag="AC0DU4_001153"
     CDS             complement(3804..4259)
                     /locus_tag="AC0DU4_001153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001081770.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HIN4237118.1"
                     /translation="MNRREAVEFVNMCMIKNGDKVLVQDRVSPDWPGITFPGGHVERG
                     ESFVDAVIREVKEETGLIISKPQLCGIKNWYDDKDYRYVVLFYKTEHFTGELQSSDEG
                     KVWWEDFENLSHLKLATDDMSDMLRVFLEEDLSEFFYYKNGDDWLYDLK"
     gene            complement(4279..5454)
                     /locus_tag="AC0DU4_001154"
     CDS             complement(4279..5454)
                     /locus_tag="AC0DU4_001154"
                     /EC_number="1.14.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HIN4237119.1"
                     /translation="MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAG
                     TGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIINFFTENGVKLKVEDHGR
                     VFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDNQFVLKSADQTFTCEKLIV
                     TTGGKSYPSTGSTGFGHEIARHFKHTITDLEAAESPLLTDFPHKALQGISLDDVTLSY
                     GKHVITHDLLFTHFGLSGPAALRMSSFVKGGEVLSLDVLPQLSEKDLVTFLEENREKS
                     LKNALKTLLPERLAEFFVQGYPEKVKQLTEKEREQLVQSIKELKIPVTGKMSLAKSFV
                     TKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAGSLHYD"
     gene            complement(5513..6358)
                     /locus_tag="AC0DU4_001155"
     CDS             complement(5513..6358)
                     /locus_tag="AC0DU4_001155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HIN4237120.1"
                     /translation="MTWKIIADSGCDYRQLPTPAINTTFVSVPLTIQVADQVFVDDAS
                     LDIDQMMETMYATAEASKSACPSPDDYLRAFEGAKNIFLVTITGTLSGSHNSAQLAKN
                     IYLEDHPDTKIHVIDSLSAGGEVDLLVEKLNDLIDQGLSFEEVVEAITAYQEKTKLLF
                     VLAKVDNLVKNGRLSKLIGTVVGLLNIRMVGKASETGTLELLQKARGSKKSVQAAYDE
                     LVKAGYAGGRIVMAQRNNEKCCQQLSERIRETFPQADIKILPTSGLCSFYAEEGGLLM
                     GYEID"
     gene            6483..7040
                     /locus_tag="AC0DU4_001156"
     CDS             6483..7040
                     /locus_tag="AC0DU4_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HIN4237121.1"
                     /translation="MSERRISEKSLENLRKSNQESNLLTREAIETALLQLLEKKELTK
                     ISISELVKRAGVSRAAFYRNYDSKEEILESVFKRTVHNIMEQLHHYDLKTDLYLVWVH
                     LFREARKEARVIQLALDYHLEKIFVQAMQEFLEKYHGKSKGVSSYLHSFWSSAIVSVL
                     LKWIKDGMKVPAEKIADLGLPFFKK"
     gene            7059..7526
                     /locus_tag="AC0DU4_001157"
     CDS             7059..7526
                     /locus_tag="AC0DU4_001157"
                     /EC_number="3.5.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000138511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004132 - dCMP deaminase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0006220 - pyrimidine nucleotide metabolic
                     process [Evidence IEA];
                     GO_process: GO:0009972 - cytidine deamination [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="deoxycytidylate deaminase"
                     /protein_id="HIN4237122.1"
                     /translation="MTEKRLAWDEYFAAQALLIANRSTCKRAKVGAILVKDNKVISTG
                     YNGSVSGTEHCIDHECLVIEGHCVRTLHAEVNAILQGAERGVPKGFTAYVTHFPCLNC
                     TKQLLQVGCKRVVYINQYRMDDYAQYLYQEKGTELTHLPLETVQTALKEADLM"
     gene            7615..8244
                     /gene="upp"
                     /locus_tag="AC0DU4_001158"
     CDS             7615..8244
                     /gene="upp"
                     /locus_tag="AC0DU4_001158"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002883819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004845 - uracil phosphoribosyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HIN4237123.1"
                     /translation="MGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEV
                     LRDLPLEDVEIETPITKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGM
                     YRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASNIKFVCL
                     VSAPEGVKALQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK"
     gene            8418..9008
                     /gene="clpP"
                     /locus_tag="AC0DU4_001159"
     CDS             8418..9008
                     /gene="clpP"
                     /locus_tag="AC0DU4_001159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit
                     ClpP"
                     /protein_id="HIN4237124.1"
                     /translation="MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIA
                     QLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIA
                     SSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
                     SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN"
     gene            9087..9335
                     /locus_tag="AC0DU4_001160"
     CDS             9087..9335
                     /locus_tag="AC0DU4_001160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbG family protein"
                     /protein_id="HIN4237125.1"
                     /translation="MFEKVNRSGLIIYLYYNRDAKKLQDYGDITYHSKKHRYLQLYVP
                     TQEVEQLVGRLSKEKFIKKVRVCHIQELETPFVGNLYR"
     gene            9437..10597
                     /locus_tag="AC0DU4_001161"
     CDS             9437..10597
                     /locus_tag="AC0DU4_001161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4237126.1"
                     /translation="MKKKFALSFVALASVALLAACGEVKSGAVNTAGNSVEEKTIKIG
                     FNFEESGSLAAYGTAEQKGAQLAVDEINAAGGIDGKQIEVVDKDNKSETAEAASVTTN
                     LVTQSKVSAVVGPATSGATAAAVANATKAGVPLISPSATQDGLTKGQDYLFIGTFQDS
                     FQGKIISNYVSEKLNAKKVVLYTDNASDYAKGIAKSFRESYKGEIVADETFVAGDTDF
                     QAALTKMKGKDFDAIVVPGYYNEAGKIVNQARGMGIDKPIVGGDGFNGEEFVQQATAE
                     KASNIYFISGFSTTVEVSAKAKAFLDAYRAKYNEEPSTFAALAYDSVHLVANAAKGAK
                     NSGEIKDSLAKTKDFEGVTGQTSFDADHNTVKTAYMMTMNNGKVEAAEVVKP"
     gene            10865..11734
                     /locus_tag="AC0DU4_001162"
     CDS             10865..11734
                     /locus_tag="AC0DU4_001162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0015803 - branched-chain amino acid
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HIN4237127.1"
                     /translation="MLQQLVNGLILGSVYALLALGYTMVYGIIKLINFAHGDIYMMGA
                     FIGYFLINSFQMNFFVALIVAMLATAILGVVIEFLAYRPLRHSTRIAVLITAIGVSFL
                     LEYGMVYLVGANTRAFPQAIQTVRYDLGPISLTNVQLMILAISLILMILLQVIVQKTK
                     MGKAMRAVSVDSDAAQLMGINVNRTISFTFALGSALAGAAGVLIALYYNSLEPLMGVT
                     PGLKSFVAAVLGGIGIIPGAALGGFVIGLLETFATAFGMSDFRDAIVYGILLLILIVR
                     PAGILGKNVKEKV"
     gene            11738..12694
                     /locus_tag="AC0DU4_001163"
     CDS             11738..12694
                     /locus_tag="AC0DU4_001163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0015803 - branched-chain amino acid
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HIN4237128.1"
                     /translation="MKENLKVNILWLLLLLAGYSLISVLVSVGVLNLFYVQILQQIGI
                     NIILAVGLNLIVGFSGQFSLGHAGFMAIGAYAAAIIGSKSPTYGAFFGAMLVGALLSG
                     AVALLVGIPTLRLKGDYLAVATLGVSEIIRIFIINGGSLTNGAAGILGIPNFTTWQMV
                     YFFVVITTIATLNFLRSPIGRSTLSVREDEIAAESVGVNTTKIKIIAFVFGAITASIA
                     GSLQAGFIGSVVPKDYTFINSINVLIIVVFGGLGSITGAIVSAIVLGILNMLLQDVAS
                     VRMIIYALALVLVMIFRPGGLLGTWELSLSRFFKKSKKEEQN"
     gene            12694..13458
                     /locus_tag="AC0DU4_001164"
     CDS             12694..13458
                     /locus_tag="AC0DU4_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237129.1"
                     /translation="MALLEVKQLTKHFGGLTAVGDVTLELNEGELVGLIGPNGAGKTT
                     LFNLLTGVYEPSEGTVTLDGHLLNGKSPYKIASLGLGRTFQNIRLFKDLTVLDNVLIA
                     FGNHHKQHVFTSFLRLPAFYKSEKELKAKALELLKIFDLDGDAETLAKNLSYGQQRRL
                     EIVRALATEPKILFLDEPAAGMNPQETAELTELIRRIKDEFKITIMLIEHDMNLVMEV
                     TERIYVLEYGRLIAQGTPDEIKTNKRVIEAYLGGEA"
     gene            13458..14168
                     /locus_tag="AC0DU4_001165"
     CDS             13458..14168
                     /locus_tag="AC0DU4_001165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000062217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237130.1"
                     /translation="MSMLKVENLSVHYGMIQAVRDVSFEVNEGEVVSLIGANGAGKTT
                     ILRTLSGLVRPSSGKIEFLGQEIQKMPAQKIVAGGLSQVPEGRHVFPGLTVMENLEMG
                     AFLKKNREENQANLKKVFSRFPRLEERKNQDAATLSGGEQQMLAMGRALMSTPKLLLL
                     DEPSMGLAPIFIQEIFDIIQDIQKQGTTVLLIEQNANKALAISDRGYVLETGKIVLSG
                     TGKELASSEEVRKAYLGG"
     gene            14476..15132
                     /locus_tag="AC0DU4_001166"
     CDS             14476..15132
                     /locus_tag="AC0DU4_001166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HIN4237131.1"
                     /translation="MAVKDFMTRKVVYISPDTTVSHAADLMREQGLHRLPVIENDQLV
                     GLVTEGTIAQASPSKATSLSIYEMNYLLNKTKVKDVMIRDVVTVSGYASLEDATYLML
                     KNKIGILPVVDNHQVYGVITDRDVFQAFLEIAGYGEEGIRVRFVTEDEVGVLGKIISL
                     IVEENLNISHTVNIPRKDGKVIIEVQIDGSIDLPALKEKFEANGIQVEEIARTSAKVL
                     "
     gene            15240..16335
                     /gene="prfB"
                     /locus_tag="AC0DU4_001167"
     CDS             join(15240..15311,15313..16335)
                     /gene="prfB"
                     /locus_tag="AC0DU4_001167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511312.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0016149 - translation release factor
                     activity, codon specific [Evidence IEA];
                     GO_process: GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HIN4237132.1"
                     /translation="MDISVIRQKIDANREKLASFRGSLDLEGLEEEIAILENKMTEPD
                     FWNDNIAAQKTSQELNELKNTYNTFHKMEELQDEVEILLDFLAEDESVHDELVAQLAE
                     LDKIMTSYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDMLLRMYTRYGNAKGFKV
                     EVLDYQAGDEAGIKSVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFTSVE
                     VMPELDDTIEVEIREDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVQSTVDRT
                     QYGNRDRAMKMLQAKLYQMEQEKKAAEVDSLKGEKKEITWGSQIRSYVFTPYTMVKDH
                     RTSYEVAQVDKVMDGDLDGFIDAYLKWRIS"
     gene            16353..17045
                     /gene="ftsE"
                     /locus_tag="AC0DU4_001168"
     CDS             16353..17045
                     /gene="ftsE"
                     /locus_tag="AC0DU4_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division ATP-binding protein FtsE"
                     /protein_id="HIN4237133.1"
                     /translation="MSIIEMRDVVKKYDNGTTALRGVSVSVQPGEFAYIVGPSGAGKS
                     TFIRSLYREVKIDKGSLSVAGFNLVKIKKKDVPLLRRSVGVVFQDYKLLPKKTVYENI
                     AYAMEVIGENRRNIKRRVMEVLDLVGLKHKVRSFPNELSGGEQQRIAIARAIVNNPKV
                     LIADEPTGNLDPDNSWEIMNLLERINLQGTTILMATHNSQIVNTLRHRVIAIENGRVV
                     RDESKGEYGYDD"
     gene            17038..17964
                     /gene="ftsX"
                     /locus_tag="AC0DU4_001169"
     CDS             17038..17964
                     /gene="ftsX"
                     /locus_tag="AC0DU4_001169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="permease-like cell division protein FtsX"
                     /protein_id="HIN4237134.1"
                     /translation="MISRFFRHLFEALKSLKRNGWMTVAAVSSVMITLTLVAIFASVI
                     FNTAKLATDIENNVRVVVYIRKDVEDNSQTIEKEGQTVTNNDYHKVYDSLKNMSTVKS
                     VTFSSKEEQYEKLTEIMGDNWKIFEGDANPLYDAYIVEANTPNDVKTIAEDAKKIEGV
                     SEVQDGGANTERLFKLASFIRVWGLGIAALLIFIAVFLISNTIRITIISRSREIQIMR
                     LVGAKNSYIRGPFLLEGAFIGLLGAIAPSVLVFIVYQIVYQSVNKSLVGQNLSMISPD
                     LFSPLMIALLFVIGVFIGSLGSGISMRRFLKI"
     gene            18250..20430
                     /locus_tag="AC0DU4_001170"
     CDS             18250..20430
                     /locus_tag="AC0DU4_001170"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000974069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015144 - carbohydrate transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit IIBC"
                     /protein_id="HIN4237135.1"
                     /translation="MMKDTFKNVLSFEFWQKFGKALMVVIAVMPAAGLMISIGKSIVM
                     INPTFAPLVITGGILEQIGWGVIGNLHILFALAIGGSWAKERAGGAFAAGLAFILINR
                     ITGTIFGVSGDMLKNPDAMVTTFFGGSIKVADYFISVLEAPALNMGVFVGIISGFVGA
                     TAYNKYYNFRKLPDALSFFNGKRFVPFVVILRSAIAAILLAAFWPVVQTGINNFGIWI
                     ANSQETAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYDILTGAAKGTQVFG
                     QDPLWLAWVTDLVNLKGTDASQYQHLLDTVHPARFKVGQMIGSFGILMGVIVAIYRNV
                     DADKKHKYKGMMIATALATFLTGVTEPIEYMFMFIATPMYLVYSLVQGAAFAMADVVN
                     LRMHSFGSIEFLTRTPIAISAGIGMDIVNFVWVTVLFAVIMYFIANFMIQKFNYATPG
                     RNGNYETAEGSEETSSEVKVAAGSQAVNIINLLGGRVNIVDVDACMTRLRVTVKDADK
                     VGNAEQWKAEGAMGLVMKGQGVQAIYGPKADILKSDIQDILDSGEIIPETLPSQMTEV
                     QQNTVHFKDLTEEVYSVADGQVVALEQVKDPVFAQKMMGDGFAVEPANGNIVSPVSGT
                     VSSIFPTKHAFGIVTEAGLEVLVHIGLDTVSLEGKPFTVHVAEGQKVAAGDLLVTADL
                     NAIRAAGRETSTVVVFTNGDAIKSVKLEKTGSLAAKTAVAKVEL"
     gene            20482..21297
                     /locus_tag="AC0DU4_001171"
     CDS             20482..21297
                     /locus_tag="AC0DU4_001171"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HIN4237136.1"
                     /translation="MKFLTLNTHSWMEKEAEEKFQILLEDILEKDYDLICFQEINQEM
                     TSSEVEVNDLYQALPAAEPIHQDHYVRLLVEKLSEQGKNYYWTWAYNHIGYDRYHEGV
                     AILSKTPIEAREILVSDVDDPTDYHTRRVALAETVVDGKELAVASVHLSWWDKGFQEE
                     WARFEAVLKKLNKPLLLAGDFNNPAGQEGYQAILASPLGLQDAFEVAQEKSGSYTVPP
                     EIDGWKGNTEPLRIDYVFTTKELAVENLHVVFDGNKSPQVSDHYGLNAMLNWK"
BASE COUNT         6530 a         4016 c         4645 g         6129 t
ORIGIN      
        1 actattatat aatgcttttt gattttagtt tagtattatc gtagaaaatg gactcggtgc
       61 tatggataca ccggatgaga atggttatgt agcagataac tatcggatta cttacttaga
      121 ggcccacatc aaggccatgc gagatgccat ttaccaagac ggggttgact tgcttggtta
      181 tacgacttgg ggctgtatcg atctggtttc agctggcaca ggggaaatga ataagcgcta
      241 tggctttatc tatgtagatc gagataatgt aggaaacgga gctctcaaac gtagcaagaa
      301 gaagtccttc tattggtaca aggatgtcat tgatagcaat ggtgcaagca tcgggtagag
      361 cacatttgtt tactattttt ataaaatctt ctccctgctt tataagatgt aaaaaagagt
      421 tcaattcgaa ctcttttttt gctataatga ggggagaaaa atcagacagg agatcgacat
      481 gtcagaacca ttatttttac aatcagttat gcaagaaaaa atctggggtg gagccaagct
      541 acgtgatgag tttggctacg acatcccaag tgaaaaaatc ggagaatatt gggccatctc
      601 agcccatcca aatggagtct ctaaagttgc caatggtcgt tacgagggaa cagatcttgc
      661 tactttgtat gcggaacacc gtgaattatt tggcaatcgt ccagaacctg tatttccact
      721 tttgaccaag atcctcgatg ccaacgactg gctcagtgtc caagttcacc cagacgatgc
      781 ttatggactc gagcatgaag gcgaactcgg aaaaacagaa tgctggtaca ttatcgcagc
      841 ggatgaaggt tcagagatta tctacggtca caatgccaag tcaaaagaag aactccgcca
      901 gcaaatcgag gataagaact gggatgcgct gttgacaaaa gtgccagtta aagcaggaga
      961 tttcttctat gtaccaagcg gtaccatgca cgctatcggg gcgggtatct tgattcttga
     1021 aacccagcag tctagcgata ccacttaccg tgtctatgac tttgaccgaa aggacgataa
     1081 gggcaacttg cgtgaacttc accttgaaaa atctatcgat gtcttgaaca ttggtgaacc
     1141 cgcaaatagc cgtccagtga caatcaaagc agatgatcta cgttccactc tccttgtatc
     1201 caatgatttc ttcgcagttt acaaatggga aattactgga aaagttaact ttgaaaagac
     1261 agctgactac agcttgttga gtgtcttggc tggtcaaggt caactaactg ttgacgggaa
     1321 aaactatcca atccaaaaag ggagacactt tatcctacca agtgatgttg aatcttggac
     1381 tttagaaggg caagatttgg aattgattgt tagtcatcca taaaaagaaa gggcctgagt
     1441 tcactactca agtccttttt gattacataa attgggcgat gaagaccacg atgatgattg
     1501 gaatgacgaa acgaagaaac gaaggaggaa gagccagact tggaaaagta cttgtttcca
     1561 ggctctttca tcgagatgga gttcctccat aacaagagcc tttttaaaga tatagcctgt
     1621 aaaaagtgaa aggcagagag ctccaaatgg catgagaaga ttggaaacca agaaatccat
     1681 ggcatcaaag aaagtcttac caaagatgtg aacatccgcc ataactccat aggatagggc
     1741 tgaaggaatg ccaaagacaa aggtcaaaat tcctaaaata acactccatt tggcacgttt
     1801 gctgttatcc tggttggtga tattgcccac attgatctcc agcatcacga cagaaaaagt
     1861 gactggcgca aaaaggaaga gcaagaggaa aaggacgtag aaaatggttc caaaaggcat
     1921 cttgtcaaag agttgaggca agacgataaa gagcaagctc ggtccccctt cagactggat
     1981 attgaagggg gaccgagctt ggaaaatggc tagacctgcc atgatggata tcgagatatt
     2041 catggctacg atggagattc ctgactggac taggttggtt ttcttgtcca agtaagaagc
     2101 ataggtcaac atgactgtaa cccctagtga gagggcaaag aaagattgtc ccagagcata
     2161 gaggagacca gcgctagtca gttttgaaaa gtctggtttg aggaagtaaa gaaccccttc
     2221 catggcattt ggcaaactga gagagcgacc gatgataaca acaaagatga taaagagcag
     2281 gggcatcatg actttcgaag ctctttcaat ccctttttga accccacgtg atacaataaa
     2341 gatatttaat aagataaagg ctgcttgagc tcctagggca atggctggat ttgaaatgat
     2401 tgaagtaaat aactgagcat aatcacccgt tccaccaagt tggaacaatt tcccaaactc
     2461 aatacctaga tagactagaa tccatcctcc gataacactg taaaaagata agaggataaa
     2521 gagggcaaag gcgccaatcc aaccgataaa gttgtacttg ttattcttgc ccagttttcc
     2581 aaaggttttg atagcggaaa cgccagcact acggccaagg gcaaactcag ccagcaggag
     2641 agggaaaccg attaaaatag tggaaatgag aaagattagt aaaaagcctc catcgccatt
     2701 agcagcagtc atgtagggaa acttccaaac ggaaccaagc ccgatggcca gccagcagat
     2761 gctagaataa aaccaagttt cgacccccat tgtgattttt ctgacatagt taaactctga
     2821 tctccttttt caaaataaga aaaagctact tgagttgtca aatagccttc tgtttgattg
     2881 atagacttga ctatcctatc atgttttcta aggtctgtca agaaaatcat tttcaagttt
     2941 tcacaccttt ctcaaaaaag ttaaaaaatt ttctcaaaaa cgcttgactc tgacctaagg
     3001 ggaggggtta tactatcatt gtaaggagga aatcatgtac catataaaag aagctgcgca
     3061 gctttcaggt gtctctgtca agaccctgca tcactatgac aagataggac tcttggtccc
     3121 cttaaagtcg gaaaacggct atcgaaccta cagtcaagag gatttggaac gccttcaggt
     3181 cattctttac tacaaatatc taggcttttc tttagagaaa atagcagagc tgttaaagga
     3241 agaaaggaca gatttattgc cccatttgac taggcagttg gactatctaa ctcgcgaaag
     3301 gcaacatctg gataccttga tttccacctt gcaaaaaact attcaagaac aaaaaggaga
     3361 aagaaaaatg accattgagg aaaaattcac gggatttagc tatcaagaca atcaaaaata
     3421 ccaccaagaa gcggtagaga aatatggtca agaagtcatg ggacaagcgc tcgaacgcca
     3481 aaaaggtcac gaagacgagg ctacggccgc ctttaaccaa gtctttcaaa ctttggcaca
     3541 aaatcttcaa gttggtttac ctgcaacagc aaccgaaaac caagagcaag cagccaagct
     3601 cttgcaagcc attcgcactt atggatttga ctgctctatt gaggtattcg gtcatatcgg
     3661 taaaggttac gtctataacc cagagtttaa ggaaaacatt gacaagtttg gttctggaac
     3721 agcccagtac acgtcagatg ccattgcagc ttacgttcag acaaatgcag aaaaaatagg
     3781 ctaggaattt cctagcctat tttttacttc aaatcataaa gccagtcgtc accgtttttg
     3841 tagtaaaaga attcactgag atcttcttct agaaacacac gaagcatatc agacatatca
     3901 tcggttgcaa gttttagatg agaaagattt tcaaagtcct cccaccaaac tttcccttcg
     3961 tctgaagact ggagttcacc agtaaagtgt tctgtcttgt aaaaaaggac gacataacga
     4021 taatccttgt cgtcatacca gtttttgata ccacagagtt ggggtttgga aatgatcaga
     4081 ccagtttctt ctttcacttc acgaatgaca gcatcgacaa aggattcgcc acgttcaaca
     4141 tgaccaccag gaaaagtaat gccaggccag tcgggactaa ctcggtcttg gaccaggacc
     4201 ttatctccgt ttttaatcat acacatgtta acaaattcga ctgcctctct tctgttcatt
     4261 cttcacaacc tttaatcttt aatcataatg cagacttccc gccacccagc cggtacagag
     4321 ggcagaagtg atgttaaagc cacccgtgtg ggcattgata tccataactt cgcctgcaaa
     4381 gtggaggcca ggtaccagct tactttcaag ggttttagga ttgatttcct tgagactgac
     4441 tccacccttg gtaacaaagg actttgcaag ggacattttt ccagttacag gaattttaag
     4501 ttctttaatg gactggacaa gctgttctcg ttccttttca gtcagctgtt tgactttttc
     4561 aggatatcct tgtacaaaaa attcggccaa gcgttctggt aacaaggttt ttaaagcgtt
     4621 tttcaaggat ttttcccgat tttcttctag aaatgtaacc aagtccttct cagaaagttg
     4681 aggcaaaaca tcgagtgaga gaacctcccc acctttgaca aagctagaca tgcgtagggc
     4741 agcaggacct gacaaaccaa agtgggtaaa gagtaaatca tgagtgatga catgcttacc
     4801 ataacttagg gtcacatcgt ccaaagaaat cccttgtaag gctttatgtg gaaaatctgt
     4861 taataaagga ctttcagcag cctcaagatc ggtgatggta tgcttaaaat ggcgagcaat
     4921 ctcgtgacca aaaccagtcg aaccagtcga aggataagac ttaccacctg ttgtgacaat
     4981 gagtttctca caagtgaagg tttgatccgc tgacttaagg acaaactggt tatctacttt
     5041 tttaacagaa acgatttcta tttgagtagc aacttgacca cctagttcgg tgattttctt
     5101 ttccaaagct tcgataatag tccgagactt gtcactggct ggaaagacgc gtccgtggtc
     5161 ttcgacctta agtttaacac cattttctgt aaaaaagttg atgatgtcat gattatcgaa
     5221 ctgggagaaa acactgtaaa gaaagcgtcc gtttccagga attccagcta gcaggttgtc
     5281 taagctacca ttgttggtca cattgcaacg tcccccacca gtcccagcta atttttttcc
     5341 aagtttccga tttttttcga tgaggagggt tttctgtcca taaaagctac tggaaatcgt
     5401 agccatcata ccagcaggtc ccccaccgat gacaatagta tcaaaatgtt tcatagctct
     5461 attgtaccac aaaaaaacaa gagatgatgg tcacctcttg tcaagaatgc aattaatcaa
     5521 tttcatagcc catcagcaaa ccgccctctt ctgcatagaa actgcagaga ccagaggttg
     5581 gtagaatttt aatatccgct tgtgggaagg tttcacggat tcgctctgag agctgttgac
     5641 aacatttttc gttattgcgt tgggccatga caatacggcc accagcatat ccagctttta
     5701 ctaactcatc ataggcagct tgaactgatt tctttgatcc ccttgctttt tgtagcaatt
     5761 cgagagtccc agtttcacta gcttttccga ccatacgaat gttgagaagg ccaacgaccg
     5821 taccgataag cttgctcaaa cggccgttct tcaccaagtt atcgactttg gctaggacaa
     5881 agagcaactt agttttttct tgataggcgg tgatagcttc aaccacttct tcaaaagaca
     5941 agccctggtc aatcaagtca ttcaattttt ctacgagtag gtcaacttca ccaccagcag
     6001 ataaactatc aatcacatga atcttagtgt caggatggtc ttccagataa atattctttg
     6061 ctagttgagc actattgtga ctgccagaaa gggtacctgt gatggttact aggaaaatgt
     6121 ttttggcacc ttcaaatgct cgcaaatagt catctgggct tggacaagct gattttgaag
     6181 cttctgcagt tgcatacatg gtttccatca tttggtcaat atcgagactg gcgtcatcaa
     6241 caaagacctg atcagctact tgaatggtta aggggacact tacaaaggtt gtgttaatag
     6301 ctggtgttgg cagttgacga taatcacaac cagagtcagc aataatcttc caagtcatag
     6361 aaattctcca tctttgtcag ttatacattg acaaaggttc tgtctttttt tacaattata
     6421 tcatgaaaac tcttgaaaca aaagcatcat ccgtctgttg tgacaagtag aaagaaaatg
     6481 ttatgtctga acgtagaatc tctgaaaagt ctcttgaaaa tctcagaaaa tcaaatcaag
     6541 aatccaattt attaaccaga gaagccattg aaacagccct cttgcaactc ttggaaaaaa
     6601 aggagctgac caagattagt atttctgaat tggtcaaacg tgcaggtgtt tcgcgtgcgg
     6661 ccttttatcg caattatgac tccaaagagg aaattttaga gagcgtcttt aaacgaactg
     6721 tccacaatat tatggaacag ctgcatcatt acgatttaaa gacagacctt tatttggttt
     6781 gggttcacct tttccgggag gccagaaagg aagctagagt aattcaattg gccttggatt
     6841 accatctgga aaaaatcttt gtccaagcca tgcaggaatt tctagaaaaa taccatggga
     6901 aatcaaaagg tgtcagctct tatcttcatt ccttctggag ctcagccatc gtctctgtcc
     6961 ttctaaaatg gatcaaggat ggcatgaagg taccagctga aaagattgca gatttaggtt
     7021 taccattttt taaaaaatag agaaaaagga gaaaagagat gactgaaaaa agactggcct
     7081 gggatgagta ttttgcagcc caagccctac taattgcgaa tcgttccact tgtaaacgtg
     7141 ctaaagtggg cgcgattctg gtaaaagata ataaggttat ttccactggt tacaatggtt
     7201 cggtgtcagg gactgagcat tgtattgatc acgaatgttt ggtcattgaa ggccactgtg
     7261 ttcgcaccct tcacgctgag gtcaatgcta tccttcaagg tgctgagcgt ggtgttccca
     7321 aaggctttac agcctatgta acccattttc cttgtctcaa ctgtacaaaa caattgcttc
     7381 aggtcggctg caagcgcgtg gtttatatca accagtaccg aatggacgac tacgcccaat
     7441 acctttatca agaaaaaggg acagaattga cccatttacc acttgagaca gtacagacag
     7501 ctcttaaaga ggctgatcta atgtaaaaat tatcaaaaat aaatggttta gaaagatttt
     7561 taaaccgttt tttggtataa tgagaagaat aaattgaaag aaggaattcc aaaaatggga
     7621 aaaattgaag ttattaatca cccactgatt caacacaaat tgtcaatctt gcgtcgtaca
     7681 gatacttcta caaaagcttt tcgtgagcta gtagatgaga ttgcaatgtt gatggggtat
     7741 gaagtacttc gtgatcttcc actagaagat gtggaaatcg aaacaccaat tacaaaaaca
     7801 gttcaaaaac aattggcagg taagaaattg gccatcgtcc caatcttgcg tgcaggtatc
     7861 gggatggttg atggtctctt gagcttggtt ccagctgcta aagttggcca catcggtatg
     7921 taccgtgatg aagaaacact tcaaccagtt gaatacttgg tgaaattgcc tgaggacatt
     7981 gaccaacgtc aaatttttgt agtagaccca atgttggcaa caggtggctc agcaatcttg
     8041 gctgttgatt ctcttaaaaa acgtggcgca tcaaatatca aatttgtctg ccttgtatct
     8101 gctccagagg gtgtaaaagc ccttcaagaa gctcatccag atgtagaaat ctttacagca
     8161 gccttggatg aacgtttgaa cgaacacggt tatatcgttc caggtcttgg agatgctgga
     8221 gaccgcttgt tcggtacaaa ataagatcga aaagaagaat gacttggaaa agtatttcca
     8281 gtcacgaaag gaggttgggt ttttgtttct gtctaatgaa agcagagcaa aaatttgacc
     8341 ttttttgacc aagatattat aatagtctta tcttcagtca tttgaccaac aaaattaaaa
     8401 ctcaaaagga gaaatgaatg attcctgtag ttattgaaca aacaagccgt ggagaacgtt
     8461 cttacgatat ttactcacgt cttctcaaag accgcatcat tatgctgaca ggtccggttg
     8521 aagacaatat ggctaactct gttattgccc aattgctttt cttggatgcc caagatagta
     8581 caaaagatat ttacctttat gtcaatacac caggtggttc tgtttcagct ggtttggcaa
     8641 tcgtagatac catgaacttt atcaaggcag atgtccaaac cattgttatg ggaatggctg
     8701 catctatggg aacagtcatc gcatcaagtg gagcaaaagg caaacgtttc atgcttccaa
     8761 atgctgaata catgattcat caaccaatgg gcggtacagg tggtggtacc caacaaactg
     8821 atatggctat cgctgcagaa cacttgctca aaactcgtaa taccttggaa aaaatcttgg
     8881 ctgaaaattc aggtcagtca atggaaaaag tccatgcaga tgcagaacgt gataactgga
     8941 tgagcgccca ggaaacactt gaatatggct ttattgatga aattatggcc aacaattcat
     9001 tgaactaatg atgatagaag gcaaactcga ctgggtttgc tttttttggt ataataggga
     9061 gagatttctt agaaagagga tttatcatgt ttgaaaaagt caatcgctct ggcttgatta
     9121 tctatcttta ctataatcgt gatgccaaaa aactgcagga ttatggagat attacctatc
     9181 attccaagaa acatcgttac ttacaactct atgttccaac tcaagaagtg gagcaattgg
     9241 tcggacgctt gagcaaggaa aaatttatta aaaaagttag agtttgtcat atccaagagt
     9301 tggaaacacc ctttgtgggc aatctttatc gataggaaaa cgttatcatc gaaaaagttc
     9361 aaggaaaaca ttgacaattt tctgataatt cggtatattc ttaacagact atttaagaaa
     9421 taaggagaca aaaaagatga agaaaaaatt tgccctatcg tttgtggcgc ttgcaagtgt
     9481 agcacttctt gcagcctgtg gagaagtgaa gtctggagca gtcaacactg ctggtaactc
     9541 agtagaggaa aagacaatta aaatcgggtt taactttgaa gaatcaggtt ctttagctgc
     9601 atacggaaca gctgaacaaa aaggtgccca attggctgtt gatgaaatca atgccgcagg
     9661 tggtatcgat ggaaaacaaa tcgaagtagt cgataaagat aataagtctg aaacagctga
     9721 ggctgcttca gttacaacta accttgtaac ccaatctaaa gtatcagcag tcgtaggacc
     9781 tgcgacatct ggtgcgactg cagctgcggt agcgaacgct acaaaagcag gtgttccctt
     9841 gatctcacca agtgcgactc aagatggatt gactaaaggt caagattacc tctttattgg
     9901 aactttccaa gatagcttcc aaggaaaaat tatctcaaac tatgtttctg aaaaattaaa
     9961 tgctaagaaa gttgttcttt acactgacaa tgccagtgac tatgctaaag ggattgccaa
    10021 atctttccgc gagtcataca agggtgaaat cgttgcagat gaaactttcg tagcaggtga
    10081 cacagacttc caagcagccc ttacaaaaat gaaagggaaa gactttgatg ctatcgttgt
    10141 tcctggttac tataatgagg ctggtaagat tgtaaaccaa gcgcgtggca tgggaattga
    10201 caaaccaatc gttggtggtg atggattcaa cggtgaggag tttgtacaac aagcaactgc
    10261 tgaaaaagca tcaaacatct actttatctc aggcttctca actactgtag aagtttcagc
    10321 taaagctaaa gccttccttg acgcttaccg tgctaagtac aatgaagagc cttcaacatt
    10381 tgcagccttg gcttatgatt cagttcacct tgtagcaaac gcagcaaaag gtgctaaaaa
    10441 ttcaggtgaa atcaaggata gccttgctaa aacaaaagat tttgaaggtg taactggtca
    10501 aacaagcttc gatgcagacc acaacacagt caaaactgct tacatgatga ccatgaacaa
    10561 tggtaaagtt gaagcagcag aagttgtaaa accataatag aaaaatgttg aaatagggaa
    10621 tgagcctttg actcactccc tgtttcgata tttaatactc ttcgaaaatc tcttcaaact
    10681 gcgtcaacgt cgccttggat tatatatgtg actgacttcg tcagtcttat ctacaacctc
    10741 aaagcagtgc tttgagcaac ctgcggctag tttcctagtt tgctctttga ttttcattga
    10801 gtataagaac ctatcaaaaa gtgagggaaa accctcggaa ttataaatag aaagagtgaa
    10861 tcttatgctc caacaactcg taaatggttt gattctaggt agtgtttacg cgctgttagc
    10921 cctaggatat accatggttt acggaattat caagctcatc aacttcgccc atggtgatat
    10981 ttatatgatg ggagccttta tcggttattt cttgatcaat tctttccaaa tgaatttctt
    11041 tgtagcgctt attgtagcta tgctagcgac agctattctt ggtgtcgtga ttgagtttct
    11101 tgcttaccga cctttgcgcc actctactcg tattgctgtt ttgattacgg ctattggggt
    11161 ttctttccta ttggagtatg gaatggtcta tctggttggt gccaataccc gtgccttccc
    11221 tcaagcgatt caaacagttc gatatgattt gggaccaatt agcttaacaa atgtgcagtt
    11281 aatgattttg gccatttcct tgattttgat gattttgtta caagtcattg tccaaaagac
    11341 taagatgggg aaagccatgc gtgcagtatc agtagatagc gacgcggcgc aattgatggg
    11401 gatcaatgta aaccgtacga ttagctttac cttcgctttg ggttctgctc ttgcgggtgc
    11461 ggctggtgtt ctgattgctc tttattataa ctctcttgag cctttgatgg gggttactcc
    11521 aggtcttaaa tctttcgttg ccgcagtact tggtggtatc ggaattattc ctggtgcggc
    11581 tcttggtggc tttgtgattg gtctattgga aacctttgcg acagcctttg ggatgtcaga
    11641 tttccgtgat gccattgttt atggaatctt gttgttgatc ttgattgtcc gcccagctgg
    11701 tatccttggt aagaatgtga aagagaaggt gtaaacgatg aaggaaaatt taaaagttaa
    11761 tattctatgg ttactccttt tgttagctgg ctatagcttg attagtgtac tggtttcagt
    11821 cggagtactt aatctattct atgtacagat tttacaacaa attggaatta atattatttt
    11881 ggctgttggt ctcaacttaa tcgttggttt ttcaggacaa ttttcacttg gtcatgctgg
    11941 tttcatggcg attggtgcct atgcagcagc tattattggt tctaaatcac caacctacgg
    12001 tgccttcttt ggagctatgc ttgtaggggc tttgctttca ggagcagttg ccttacttgt
    12061 cggcattcca accttgcgct tgaaggggga ctatcttgcg gtagcaactc tgggtgtttc
    12121 tgaaattatc cgtatcttta tcatcaatgg tggaagtctt acaaatggtg cggcaggtat
    12181 cttagggatt cctaacttta caacttggca aatggtttac ttctttgtcg tgattacaac
    12241 cattgcaacc ttgaacttct tgcgtagccc aattggccgt tcaaccctct ctgttcgtga
    12301 agatgaaatc gctgctgagt cagttggggt taatacgact aaaattaaaa tcatcgcttt
    12361 tgtctttggt gccattactg caagtattgc tgggtcactt caggcaggat ttatcgggtc
    12421 tgttgtaccg aaagattaca ccttcatcaa ctcaatcaac gttttgatta ttgttgtatt
    12481 tggtggactc ggttccatta caggtgcgat tgtttcggct attgttctgg gaattttgaa
    12541 tatgcttctc caagatgttg ctagtgtgcg tatgattatt tacgctttgg ccttggtatt
    12601 ggtaatgatt ttcagaccag gtggactcct tggaacgtgg gaactgagcc tatcacgttt
    12661 ctttaaaaaa tctaagaagg aggaacaaaa ctaatggcat tacttgaagt aaaacagtta
    12721 accaaacatt ttggtggtct aacagctgtt ggagatgtga ctcttgaatt gaacgaaggg
    12781 gaactggttg gattaatcgg tccaaacgga gctgggaaaa ccaccctttt caaccttttg
    12841 accggtgttt atgaaccaag cgagggaaca gtaaccctag atggtcacct tttgaatggg
    12901 aaatcacctt ataagattgc ctctttggga cttggacgta ctttccaaaa tatccgtctt
    12961 tttaaagatt taacagtttt agacaatgtt ttgattgctt ttggaaacca tcacaaacag
    13021 catgttttta ctagtttctt acgcttacca gctttttaca agagtgaaaa agaattaaag
    13081 gctaaagctt tggaattgtt gaaaatcttt gatttagatg gtgatgcaga gactcttgct
    13141 aaaaatcttt cctacggaca acaacgtcgt ttggaaattg ttcgtgccct tgctacggaa
    13201 cctaaaattc tcttcttaga tgaaccagca gcaggtatga acccacagga aacagccgaa
    13261 ttgactgagt taattcgtcg tatcaaagat gaatttaaga ttacaatcat gttgattgaa
    13321 cacgatatga atctggtcat ggaagtaaca gaacgtatct acgtacttga atatggccgt
    13381 ttaattgctc aaggaactcc agacgaaatt aagaccaata aacgcgttat cgaagcttat
    13441 ctaggaggtg aagcctaatg tctatgttaa aagttgaaaa tctttctgtg cattacggta
    13501 tgatccaagc agtccgtgat gtaagctttg aagttaatga aggagaagtt gtttccctta
    13561 tcggtgccaa cggtgcaggt aagacaacta ttcttcgcac cttgtcaggt ttggttcgac
    13621 caagttcagg aaagattgaa tttttaggtc aagaaatcca aaaaatgcca gctcagaaaa
    13681 tcgtggcagg tggtctttca caagttccag aaggacgcca cgtctttcct ggcttgactg
    13741 ttatggaaaa tcttgaaatg ggagctttct taaagaaaaa tcgtgaagaa aatcaagcta
    13801 acttgaagaa ggttttctca cgctttcctc gtcttgaaga acggaagaac caagatgcag
    13861 ctactctttc aggaggggaa caacaaatgc ttgccatggg acgcgctctt atgtcaacac
    13921 caaaacttct tcttttagat gaaccatcaa tgggacttgc cccaatcttc atccaagaga
    13981 tttttgatat cattcaagat attcagaagc aaggaacaac cgtcctcttg attgaacaaa
    14041 atgccaataa agcactcgca atctctgacc gaggatatgt attggaaaca ggaaaaatcg
    14101 tcctatcagg gacaggaaaa gaactcgctt catcagaaga agtcagaaaa gcatatctag
    14161 gtggctaaaa caatccagtg gattgtttta gtcggcagat gaagattacg aagtaatcat
    14221 caatatagtc cgggggacct ttttagccgg tagattgaga ttgcaaacaa atctgcatct
    14281 acattgaaag cttaatttct aataattgaa aaaatcgaat gaaaagtttc ttaccttcat
    14341 tcacagagct cgattttaga gctctttttg ctagcttatt catacttttc taaattttga
    14401 aaaagaaatg taagcgtttg atagatttgc aaaaagattg tataataggg ataagaatag
    14461 aaaaggagaa gtctcatggc agttaaagat tttatgaccc gcaaggtagt ttatattagt
    14521 ccagatacaa cagtatctca tgcagcagat ttgatgagag agcaaggatt gcaccgcttg
    14581 cctgttatcg aaaatgatca attggttggt ttggtgactg agggaaccat tgcacaagca
    14641 agtccatcta aagcaacaag tctttctatc tatgagatga attatcttct gaataagaca
    14701 aaagtaaaag atgtcatgat tcgcgatgtt gtcactgtct caggctatgc tagtctagaa
    14761 gatgcaactt atctgatgtt gaaaaataag attggtattc tccctgtcgt agataaccat
    14821 caagtatacg gagttattac tgaccgtgac gttttccaag cctttcttga aattgcaggt
    14881 tatggcgaag aagggattcg tgtacgcttt gttacagaag atgaagttgg tgttcttgga
    14941 aaaattattt ctttgattgt agaagaaaat ttgaatatct cccatacagt caatattccg
    15001 cgtaaggatg gtaaggtcat tatcgaagtg caaatcgatg gatcaattga tttaccagcc
    15061 ttgaaagaaa aatttgaagc aaatggtatt caagtggaag aaatcgctcg cacttcagca
    15121 aaagtcttgt aagaagggaa gcccaaaggc ttcttttttc atgaaaaggg gattagagca
    15181 aaagatggaa agaaatgata aaatatgcta taatgaaatg atgtaaaaaa ggagtattta
    15241 tggacatttc agtaattcgt cagaaaattg acgcaaatcg tgaaaaatta gcttctttca
    15301 gggggtctct ttgacctcga agggctagag gaagagattg ccatcttgga aaacaagatg
    15361 acagaacctg atttttggaa cgataatatt gcggcccaaa aaacgtcgca agaattgaat
    15421 gaattaaaaa acacttacaa taccttccat aagatggaag agttgcagga tgaagtcgaa
    15481 attttattgg attttttggc tgaagacgag tcagtgcatg atgaactggt agcgcagtta
    15541 gccgaacttg ataagataat gaccagctac gagatgactc tactcttgtc agaaccttat
    15601 gaccacaaca atgccatctt ggaaatccat ccaggttctg gtggtactga ggcgcaggac
    15661 tggggtgata tgttgcttcg tatgtatact cgttatggta atgctaaagg ctttaaagtg
    15721 gaagtgttgg attaccaagc aggtgatgag gctggtatta agtcggtaac tttatcattt
    15781 gaagggccta atgcctatgg tctcctcaag tcagaaatgg gtgttcatcg cttagtgcga
    15841 atctcaccat ttgactctgc caaacgtcgc catacctctt tcacatctgt agaagtgatg
    15901 ccagaattgg atgatactat tgaagtggaa atccgtgaag atgatatcaa gatggatacc
    15961 ttccgttcag gtggtgccgg tggacaaaac gtcaataagg tttcaacagg tgtacgttta
    16021 acccacattc caactggaat tgttgtccaa tcaacagtgg atcgtaccca gtatggaaat
    16081 agagatcgcg ccatgaagat gttgcaggct aagctctatc aaatggagca agagaagaag
    16141 gctgcggagg tagattctct caaaggtgag aaaaaggaga tcacttgggg aagtcaaatc
    16201 cgttcttatg tcttcacgcc ttatactatg gtaaaagatc accgaactag ctatgaggtt
    16261 gctcaggtag ataaggttat ggatggggac ctagatggtt ttatcgatgc ttatctcaag
    16321 tggcgaatta gctaagatag aaaggaactc acatgtcaat tattgaaatg agagatgtcg
    16381 ttaaaaaata cgacaacgga acgactgctc tacgcggtgt ttcggttagc gttcaaccgg
    16441 gggaatttgc ttacatcgta ggaccttcag gagcagggaa gtcaactttt attcgttctc
    16501 tgtatcgtga agtaaaaatc gataaaggaa gtctatcagt tgctggtttt aatctggtta
    16561 agatcaaaaa gaaagatgtc ccgcttctac gtcgtagtgt tggggttgtc ttccaagatt
    16621 ataaactgtt accaaagaaa actgtctatg aaaatattgc ttacgctatg gaagtaatcg
    16681 gggaaaatcg ccgtaatatc aaaagacgag tgatggaagt tttggacttg gttggattga
    16741 agcataaggt tcgttctttc ccaaatgaac tctcaggtgg ggagcaacag cggattgcga
    16801 ttgcgcgtgc aattgtaaat aatcccaaag tattgatagc tgatgagcca acaggaaatc
    16861 tggatccgga taattcatgg gaaattatga atctcttgga acggattaac ctacaaggaa
    16921 caactatttt gatggcgact cataatagcc agattgtaaa taccttgcgc caccgtgtca
    16981 ttgccattga aaatggccgt gtcgttcgtg acgaatcaaa aggagagtat ggatacgatg
    17041 attagtagat tttttcgcca tttatttgaa gccttaaaaa gtttgaaacg aaatggttgg
    17101 atgacagtag ctgctgtcag ttcagtcatg attactttga ccttggtggc aatatttgca
    17161 tctgttattt tcaatacagc gaaactagct acagatattg aaaataatgt ccgtgtagta
    17221 gtttatatcc gaaaggatgt ggaagataat agtcagacaa ttgaaaaaga aggtcaaact
    17281 gttacaaata atgactacca caaggtatat gattctttga agaacatgtc tacggttaaa
    17341 agtgttacct tttcaagtaa agaagaacaa tatgaaaaat taaccgagat aatgggagat
    17401 aactggaaaa tctttgaagg agatgccaat cctctctatg atgcctatat tgtagaggca
    17461 aacactccaa atgatgtaaa aactatagcc gaagatgcta aaaaaattga aggtgtctct
    17521 gaggttcaag atggcggtgc caatacagaa agactcttca agttagcttc atttatccgt
    17581 gtttggggac tagggattgc tgctttgtta atttttatcg cagttttctt gatttcaaat
    17641 accattcgta ttaccattat ttcccgcagt cgcgaaattc aaatcatgcg cttggtcgga
    17701 gctaaaaaca gttatatccg tggaccgttc ttgttagaag gagcctttat cggtttattg
    17761 ggagctatcg caccatctgt tttggtcttt attgtttatc aaattgttta ccaatctgtc
    17821 aacaaatcgt tggtagggca aaatctatcc atgattagtc cagatttatt tagtccgttg
    17881 atgattgccc tactatttgt gattggggtt ttcattggtt cattgggatc aggaatatcc
    17941 atgcgccgat tcttgaagat ttaggtaaaa tagctgcttt tatgaggaga ttgtaaaatc
    18001 tccttttttg ctacaagagt ttttgaaaag agatgcgcag aagaaaagag cttccaaaga
    18061 agtcccccag agaagacttc ttgatggcta atttgaactt gaaatttggc gcactagaaa
    18121 ttttttagaa aaaagtgtaa tttttttata aaagccttta caaaaaaaat taaagtggta
    18181 taattaaatc atagaaagtg caaacgtttt cgtaaaacgt ttgcctaaat aaaaataaag
    18241 gagatttgaa tgatgaaaga tacattcaaa aatgtcttgt ctttcgaatt ttggcaaaaa
    18301 ttcggtaagg ctttgatggt agttatcgcg gttatgccgg ctgctggttt gatgatttca
    18361 atcggtaagt ctatcgtgat gattaaccca acctttgcac cacttgtcat cacaggtgga
    18421 attcttgagc aaatcggttg gggggttatc ggtaaccttc acattttgtt tgccctagcc
    18481 attggaggaa gctgggctaa agaacgtgct ggtggtgctt tcgccgctgg tcttgccttc
    18541 atcttgatta accgtatcac tggtacaatc tttggtgtat caggcgatat gttgaaaaat
    18601 ccagatgcta tggtaactac tttctttggt ggttcaatca aagttgctga ttactttatc
    18661 agtgttcttg aagctccagc cttgaacatg ggggtattcg tagggattat ctcaggtttt
    18721 gtaggggcaa ctgcttacaa caaatactac aacttccgta aacttcctga tgcactttca
    18781 ttcttcaacg ggaaacgttt cgtaccattt gtagttattc ttcgttcagc aatcgctgca
    18841 attctacttg ctgctttctg gccagtagtt caaacaggta tcaataattt cggtatctgg
    18901 attgccaact cacaagaaac tgctccaatt cttgcaccat tcttgtatgg tactttggaa
    18961 cgtttgctct tgccatttgg tcttcaccac atgttgacta tcccaatgaa ctacacagct
    19021 cttggtggta cttatgacat tttaactggt gcagctaaag gtactcaagt attcggtcaa
    19081 gacccactat ggcttgcatg ggtaacagac cttgtaaacc ttaaaggtac tgatgctagt
    19141 caataccaac acttgttaga tacagtacat ccagctcgtt tcaaagttgg acaaatgatc
    19201 ggttcattcg gtatcttgat gggtgtgatt gttgctatct accgtaatgt tgatgctgac
    19261 aagaaacata aatacaaagg tatgatgatt gcaacagctc ttgcaacatt cttgacaggg
    19321 gttactgaac caatcgaata catgttcatg ttcatcgcaa cacctatgta tcttgtttac
    19381 tcacttgttc aaggtgctgc cttcgctatg gctgacgtcg taaacctacg tatgcactca
    19441 ttcggttcaa tcgagttctt gactcgtaca cctattgcaa tcagtgctgg tattggtatg
    19501 gatatcgtta acttcgtttg ggtaactgtt ctctttgctg taatcatgta ctttatcgca
    19561 aacttcatga ttcaaaaatt caactacgca actccagggc gcaacggaaa ctacgaaact
    19621 gctgaaggtt cagaagaaac cagcagcgaa gtgaaagttg cagcaggctc tcaagctgta
    19681 aacattatca accttcttgg tggacgtgta aacatcgttg atgttgatgc atgtatgact
    19741 cgtcttcgtg taactgttaa agatgcagat aaagtaggaa atgcagagca atggaaagca
    19801 gaaggagcta tgggtcttgt gatgaaagga caaggggttc aagctatcta cggtccaaaa
    19861 gctgacattt tgaaatctga tatccaagat atccttgatt caggtgaaat cattcctgaa
    19921 actcttccaa gccaaatgac tgaagtacaa caaaacactg ttcacttcaa agatcttact
    19981 gaggaagttt actcagtagc agacggtcaa gttgttgctt tggaacaagt aaaggatcca
    20041 gtatttgctc aaaaaatgat gggtgatgga tttgcagtag aacctgcaaa tggaaacatt
    20101 gtatctccag tttcaggtac tgtatcaagc atcttcccaa caaaacatgc ttttggtatt
    20161 gtgacggaag caggtcttga agtattggtt cacattggtt tggacacagt aagtcttgaa
    20221 ggtaaaccat ttacagttca tgttgctgaa ggacaaaaag ttgcagcagg agatctcctt
    20281 gtcacagctg acttgaatgc tatccgtgca gcaggacgtg aaacttcaac agtagttgtc
    20341 ttcacaaatg gtgatgcaat taaatcagtt aaattagaaa aaacaggttc tcttgcagct
    20401 aaaacagcag ttgctaaagt agaattgtaa tatacttgag gttggaagct gtattccaac
    20461 ctcttatttt gggagaaaag aatgaaattt ttaacactca atactcatag ttggatggag
    20521 aaagaagcag aggaaaaatt ccagattttg cttgaagata ttcttgaaaa ggactatgat
    20581 ttgatttgtt tccaagaaat taatcaggag atgacctcgt cagaggtgga ggttaatgac
    20641 ctttatcaag ctttgccagc agctgagcct attcaccaag atcactatgt tagactcttg
    20701 gttgaaaagt tatctgagca agggaaaaat tactactgga cctgggccta taaccatatc
    20761 ggctatgacc gctaccacga aggtgtggct atcttgtcta aaacacctat tgaagccaga
    20821 gaaattttgg tttcagatgt ggatgatcca acagactatc atactcgccg tgttgcccta
    20881 gctgaaactg tagtcgatgg caaggagcta gcagttgcca gtgttcatct ctcttggtgg
    20941 gataaaggtt ttcaagaaga atgggcacga tttgaggctg tcttgaaaaa attgaacaag
    21001 ccacttttac tagctggaga ttttaacaac ccagcaggtc aggaaggtta ccaagctatt
    21061 ttagctagtc cattaggctt acaagacgca tttgaagttg ctcaagagaa aagtggtagc
    21121 tatactgttc cgcctgaaat tgatggctgg aaagggaaca ctgaacccct tcgaatcgat
    21181 tatgtcttta ctaccaaaga gttagcggtg gaaaatttac atgtcgtatt tgatggtaac
    21241 aagagtccac aagtgagtga tcactatggc ttgaatgcta tgttaaactg gaaataataa
    21301 ctgaaaagag gttggaacta
//
LOCUS       DBMVGT010000028        21296 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.028, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000028 DBMVGT010000000
VERSION     DBMVGT010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 21296)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21296)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21296
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.028"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            250..1695
                     /gene="cps4A"
                     /locus_tag="AC0DU4_001172"
     CDS             250..1695
                     /gene="cps4A"
                     /locus_tag="AC0DU4_001172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4A"
                     /protein_id="HIN4237137.1"
                     /translation="MSRRFKKSSSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     IDQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTST
                     EALKNYSTIINSLQDSIQTNMPLETMINLVNAQLESGGNYKVNSQDLKGTGRTDLPSY
                     AMPDSNLYVLEIDDSSLAVVKAAIQDVMEGR"
     gene            1697..2428
                     /gene="cps4B"
                     /locus_tag="AC0DU4_001173"
     CDS             1697..2428
                     /gene="cps4B"
                     /locus_tag="AC0DU4_001173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4B"
                     /protein_id="HIN4237138.1"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRIIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVASDLVIAYGAEIYYTPDVLDKLEKKRIPTLNDS
                     RYALIEFSMNTPYRDIHSALSKILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QVNSSHVLKPKLFGERYKFMKKRAQYFLEQDLVHVIASDMHNLDGRPPHMAEAYDLVT
                     QKYGEAKAQELFIDNPRKIVMDQLI"
     gene            2437..3129
                     /gene="cpsC"
                     /locus_tag="AC0DU4_001174"
     CDS             2437..3129
                     /gene="cpsC"
                     /locus_tag="AC0DU4_001174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000664160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     CpsC"
                     /protein_id="HIN4237139.1"
                     /translation="MKEQNTIEIDVFQLFKTLWKRKLMILIVALVTGAGAFAYSTFIV
                     KPEYTSTTRIYVVNRDQGDKPGLTNQDLQAGSYLVKDYREIILSQNVLEKVATNLKLD
                     MPTKTLASKVKVTVPTDTRIVSISVKDKQPEEASRIANSLREVAAEKIVAVTRVSDVT
                     TLEEARPATTPSSPNVRRNSLFGFLGGAVVTVIAVLLIELLDTRVKRPEDVEDVLQIP
                     LLGVVPDLNKMK"
     gene            3139..3828
                     /locus_tag="AC0DU4_001175"
     CDS             3139..3828
                     /locus_tag="AC0DU4_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein kinase"
                     /protein_id="HIN4237140.1"
                     /translation="MPTLEISQAKLDFVKKAEEYYNALCTNLQLSGDDLKVFSITSVK
                     LGEGKSTTSTNIAWAFAHAGYKTLLIDGDIRNSVMLGVFKARDKITGLTEFLSGTTDL
                     SQGLCDTNVENLFVIQAGSVSPNPTALLQSKNFSTMLETLRKYFDYIIVDTAPVGVVI
                     DAAIITRKCDASILVTEVGEINRRDIQKAKEQLEHTGKPFLGVVLNKFDTSVDKYGSY
                     GNYGDYGKNKK"
     gene            3844..5211
                     /locus_tag="AC0DU4_001176"
     CDS             3844..5211
                     /locus_tag="AC0DU4_001176"
                     /EC_number="2.7.8.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HIN4237141.1"
                     /translation="MNGKIVKSSLAIIQSFLVILLTYLLSAVREAEIVSTTAIALYIL
                     HYFVFYISDYGQDFFKRGYLIELVQTLKYILFFALAISISNFFLEDRFSISRRGMIYF
                     LTLHALLVYVLNLFIKWYWKRAYPNFKGSKKILLLTATSRVEKVLDRLIESNEVVGEL
                     VAVSVLDKPDFQHDCLKVVAEGEIVNFATHEVVDEVFINLPSEKYNIGELVSQFETMG
                     IDVTVNLNAFDRSLARNKQIREMAGLNVVTFSTTFYKTSHVIAKRIIDIMGALVGLIL
                     CGLVSIVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNTM
                     QGGMFKVDDDPRITKIGCFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYEHYTPE
                     QKRRLSFKPGITGLWQVSGRSEIKNFDEVVKLDVAYIDDWTIWKDIEILLKTVKVVLM
                     KDGAK"
     gene            5242..6414
                     /gene="cps2T"
                     /locus_tag="AC0DU4_001177"
                     /gene_synonym="wchF"
     CDS             5242..6414
                     /gene="cps2T"
                     /locus_tag="AC0DU4_001177"
                     /gene_synonym="wchF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="beta 1-4 rhamnosyltransferase Cps2T"
                     /protein_id="HIN4237142.1"
                     /translation="MKQSVYIIGSKGIPAKYGGFETFVEKLTEYQKDGNIQYYVACMR
                     ENSAKSGFTADTFEYNGAICYNIDVPNIGPARAIAYDIAAVNKAIELSKGNKDEAPIF
                     YILACRIGPFISGLKKKIRSIGGRLLVNPDGHEWLRAKWSLPVRKYWKFSEQLMVKHA
                     DLLVCDSKNIEKYIREDYKQYQPKTTYIAYGTDTTPSSLKSEDAKVRNWYREKGVSEN
                     GYYLVVGRFVPENNYETMIREFIKSKSNKDFVLITNVEQNKFYDQLLKETGFDKDLRV
                     KFVGTVYDQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTKLNLLLDVGFNREVGE
                     DGAIYWKKDELAHVIEEVERFDEGDITELDEKSSQRIADAFTWEKIVSDYEEVFTV"
     gene            6411..7694
                     /locus_tag="AC0DU4_001178"
     CDS             6411..7694
                     /locus_tag="AC0DU4_001178"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HIN4237143.1"
                     /translation="MKILHYTLGFQPSRTGGLVKYAEDLMTQQATDGHEVIALYPGEI
                     SIIFRQVRIKKAENRKFQCYKIINSLPLALFGGISEPDEFMKSCDKASYRKFLKNIKV
                     DVIHIHSLIGLHKEFIEVAKELGIKTVFTSHDYYGLAPVPHFYFNGVDYSSNNTNLAW
                     NIMSSNALSVKKLRFFQVSFYPTIRKLMKMLGKNPKSKKNLVIRDITEAIDYSALRSY
                     YKAMFGLIDAYLFNSQLAKEVYEANHIIPKNNIIVSISNSSISNHNIRVSSGEKTVVA
                     YIGPDEEYKGYFDFLDIVNDLDQEKYDIKTYGHFPNEDCPPYIQQNGYFTKDTVGSVY
                     SNIDILIVPSRWKETFGLISIEALSYDVNVFVSKNVGSKDLVSEEHIFHNKDDLLKKI
                     QYVKFENVKFKTMKEHMVEIINYYERITNDNQKIN"
     gene            7657..8361
                     /locus_tag="AC0DU4_001179"
     CDS             7657..8361
                     /locus_tag="AC0DU4_001179"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000677450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0120225 - coenzyme A binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyltransferase"
                     /protein_id="HIN4237144.1"
                     /translation="MKGLQMIIKRLIKTITGKEIDLHPDIPITYILQRGFQYGLGLSR
                     GLLRGIGLGKKGKRLFIGRGVTLLAKRKLYVGNNIRIGKYVSIDCLSKDGIQIADNVK
                     IGDYSQIIGTGSVKNMGIGLKIGKNSSFSEYSLFGSAGGITIGGDVIAGQNVRFHAEN
                     HSYEVLHIPIREQGVNRKGISVGDNCWIGAGAVFLDGSSIGSGCIVATNAVVTKKFPD
                     NVIIGGVPAKILMERK"
     gene            8405..9640
                     /locus_tag="AC0DU4_001180"
     CDS             8405..9640
                     /locus_tag="AC0DU4_001180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000686363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide sugar dehydrogenase"
                     /protein_id="HIN4237145.1"
                     /translation="MKIAVVGTGYVGLSISVLLAQHHHVVAVDIVKEKVELINKRISP
                     IQDDFIERYLSESNLDLVATIDAETAYKDASFIVVATPTNYDLERNFFDTSTVESVIQ
                     QVQNMNSTATIVIKSTVPVGFTDSIRKKLGISNLLFSPEFLRESRALYDNLYPSRIIV
                     GTDLSNQKLVEKAQVFSNLLVQGAIKKDIPILTMGFTEAEAVKLFANTYLALRVSYFN
                     ELDTYAEIKGLDTQKIIEGVSLDPRIGTHYNNPSFGYGGYCLPKDTKQLLANYKNVPE
                     ELIGAIVRSNTTRKDFIANQVLKVVNYNIPEDDIPTKQMEKEVVIGIYRLTMKSNSDN
                     FRQSSIQGVMKRIKDRGVKVIIFEPTLKDSDTFFGNAVINDLEEFKVKCDVIIANRYD
                     ETLNDVKDKVYTRDIFRRD"
     gene            9648..10772
                     /locus_tag="AC0DU4_001181"
     CDS             9648..10772
                     /locus_tag="AC0DU4_001181"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HIN4237146.1"
                     /translation="MKKVLIVRSGPYQVNPEGYNLQELGLASAISQQGYQCDVMYYHK
                     TKNYDQLYEKNGEQIKIFWRRGIRLFRSGIYPQILREKFLNQYDKIIISEYSQIMAVL
                     LSRIHSNVYIYNGPYYNLFKIPIIEPIYDFLFVEMLNKRTKTVFCKTEKAECYLKNKG
                     FNDCKVVGVGLDIEKFEQEEEPTEDTIELLRRMENKQNILYVGSLSKRKNTAQLIRIF
                     NILKSKSGKKNELQLVLIGKDEDNIVEKINYSRFKDDIIYQPYLKNSQLQFIYPSSQL
                     LVLPSVQEIFGMVLLEAMYFKLPVVSSASAGGETLIQDGINGKIVNDFNDEHWVDCIE
                     NLLNNPLELKRLGECAHKRITEQFMWSSIARKIIETFDER"
     gene            10781..11623
                     /locus_tag="AC0DU4_001182"
     CDS             10781..11623
                     /locus_tag="AC0DU4_001182"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001008286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HIN4237147.1"
                     /translation="MNFCFVILHYRTSNDTIECIKSIQKLEGDYKIVIVDNASQNGSI
                     ERVEALFANNDEIVIIKNTKNLGFAAGNNIGYAYARTQIKADMIAVLNNDIVIKQKDF
                     INRIFELYRNSQFHIAGPDIVSLVDGHHQSPVVEKINSISKANKELFKYRILRIINKI
                     GLYELMTRQPKKELNRISVADPMRYQENVILHGSFVIFSPLYVSEEECAFRPDTFMYM
                     EEPILYEYCMLKNYKTVFDPSIVIYHKEDSSTNSLYNAAYAKREFVFKNMIRSLKIYR
                     SLLK"
     gene            11665..12933
                     /locus_tag="AC0DU4_001183"
     CDS             11665..12933
                     /locus_tag="AC0DU4_001183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000880578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008755 - O antigen polymerase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen polymerase"
                     /protein_id="HIN4237148.1"
                     /translation="MLALTIGTVVFVKKTYRTFLNPIILFVILWFIITTLSSLKLFQL
                     FEISTHTQQIILLGTSLFVIGGGIAIWFRDKFYFKVGGNSYFTTDFEINYNLFFLLGI
                     ICLFYYLPDFFSSLVSLIRGGNLNLVRQSAQDAVDTSGLKNFIGTFIVSPSAMVLEIL
                     GVLDFWSNKKGRKLFYLSLAVIFVRVIADAGRTPLFNVVIYLLLTVLANRFSEKTEKK
                     RKVSKIKIVNYGMLGSIILWLSTLSRTTTSVYRILYFYFAMSPILLEKWSSVLDSEKL
                     VTKGLVSLNGFFFSISYVLKNLFRIDYSQRVLEAYTMIANTDAIWYNIAPGLTKANAY
                     VSLFWFFYADGRLLGVLIGSLLYGTFCGYIFCRYIQQQNKKNLAMLLFIYQGVFFSFI
                     RFPFSKSNYAIAFVLLLFFAFKKKGIEKSV"
     gene            12926..13933
                     /locus_tag="AC0DU4_001184"
     CDS             12926..13933
                     /locus_tag="AC0DU4_001184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237149.1"
                     /translation="MFNINDQSIIYVACPYFNKTGGTELVHQLVYSINHFGGKAIVAY
                     YGSESAPNKVNPAFREYVSTFVDIKDVIDSLDNIIILPEINPDLAANLESIQKAVWWM
                     SVDNYLKRNGILGSLEHFGLLRTIKLFVKGNIKIGGYRIDKEIPHLYQSEYAKQFLLA
                     KGVKKYYRLSDYLNESYIQRSISTDTKKDVILYNPKKGIEFTRELIKQAPELTFSPIE
                     NMSTEQVKKLLSKSKVYIDFGNHPGKDRFPREAAISGCCVITGKRGSAKYYKDIPIPD
                     SYKFEDTVENIPNIIETLKSCLKNYDKHTVDFEKYQQYIKSEHDLFERDVKELFTRNR
                     G"
     gene            13938..15380
                     /locus_tag="AC0DU4_001185"
     CDS             13938..15380
                     /locus_tag="AC0DU4_001185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000107550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0140327 - flippase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="flippase"
                     /protein_id="HIN4237150.1"
                     /translation="MSTRNSLIKNSLYNVAYRMLNIIFPLVSATYTARIILASGVGEV
                     SFAQNVVSYFTTIAAMGIPNYGIREIAKTRNKAEATNKVFSELFLINGLSTLLCSIVY
                     LILILTFNSIFDNTSMYLAVGLTLVFNFLNIDWFYQGKEDYAYITKRSFSIKLISLFS
                     LFIFVRDTDDAVNYALISSLAIGGNNIFNLVNLRKYNIRFSFNNIKIRRHLKPIFVLL
                     GSVIAIEIYTMLDTTMIGAMVGTTEVGYYTNSMKLVKLLITVITAIGGVLLPRLSDYY
                     SKGEFEKLNHIVDKVFRIMLFLFLPAQVALILVAPVIMPILFGDSFIPAVLTLQLTSL
                     LICTLGFSNLFGTQILLTFGDERKLLISTILGALSNIALNLILIPVMAQNGAALASVI
                     SETIVTLTAYYYAKKRVTIRFDLGFYLPTVVSTIIMGGAIYVVMQLYIGDIEKMLFST
                     LLGGVVFLLINVFMKNPIIYEFTGIIKRKR"
     gene            15383..16483
                     /gene="glf"
                     /locus_tag="AC0DU4_001186"
     CDS             15383..16483
                     /gene="glf"
                     /locus_tag="AC0DU4_001186"
                     /EC_number="5.4.99.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000272509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008767 - UDP-galactopyranose mutase
                     activity [Evidence IEA];
                     GO_process: GO:0009273 - peptidoglycan-based cell wall
                     biogenesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
                     /protein_id="HIN4237151.1"
                     /translation="MYDYLIVGAGLSGAIFAHEATKRGKKVKVIDKRDHIGGNIYCEN
                     VEGINVHKYGAHIFHTSNKKVWDYVNQFAEFNNYINSPVANYKGSLYNLPFNMNTFYA
                     MWGTKTPQEVKDKIAEQTAGMKDVEPKNLEEQAIKLIGPDIYEKLIKGYTEKQWGRSA
                     IELPPFIIKRLPVRLTFDNNYFNDRYQGIPIGGYNVIIENMLKDVEVELGVDFFAHRE
                     ELEASANKVVFTGMIDQYFDYKHGELEYRSLRFEHEILDEENYQGNAVVNYTEREIPY
                     TRIIEHKHFEYGMQPKTVITHEYPADWKRGDEPYYPINDEKNNAMFAKYQEEAAQNDK
                     VIFCGRLADYKYYDMHVVIERALEVVEKEFSN"
     gene            16510..17379
                     /gene="rfbA"
                     /locus_tag="AC0DU4_001187"
     CDS             16510..17379
                     /gene="rfbA"
                     /locus_tag="AC0DU4_001187"
                     /EC_number="2.7.7.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002276675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA];
                     GO_process: GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="HIN4237152.1"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIRDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFISDDSV
                     ALILGDNIYHGSGLSKMLQKAASKESGATVFGYHVKDPERFGVVEFDQDMKAISIEEK
                     PEQPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLTLAQPLKKN
                     EYGQYLLRLIGEA"
     gene            17380..17973
                     /locus_tag="AC0DU4_001188"
     CDS             17380..17973
                     /locus_tag="AC0DU4_001188"
                     /EC_number="5.1.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018029578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016857 - racemase and epimerase activity,
                     acting on carbohydrates and derivatives [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase family
                     protein"
                     /protein_id="HIN4237153.1"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDL"
     gene            17986..19035
                     /gene="rfbB"
                     /locus_tag="AC0DU4_001189"
     CDS             17986..19035
                     /gene="rfbB"
                     /locus_tag="AC0DU4_001189"
                     /EC_number="4.2.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000141505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA];
                     GO_process: GO:0009225 - nucleotide-sugar metabolic
                     process [Evidence IEA];
                     GO_process: GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="HIN4237154.1"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPGVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQATD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKE
                     AVEANYAKTQEIITV"
     gene            19101..19952
                     /gene="rfbD"
                     /locus_tag="AC0DU4_001190"
     CDS             19101..19952
                     /gene="rfbD"
                     /locus_tag="AC0DU4_001190"
                     /EC_number="1.1.1.133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008831 - dTDP-4-dehydrorhamnose reductase
                     activity [Evidence IEA];
                     GO_process: GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="HIN4237155.1"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITNEEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     gene            20015..21098
                     /gene="glf"
                     /locus_tag="AC0DU4_001191"
                     /pseudo
     CDS             20015..21098
                     /gene="glf"
                     /locus_tag="AC0DU4_001191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000272499.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0008767 - UDP-galactopyranose mutase
                     activity [Evidence IEA];
                     GO_process: GO:0009273 - peptidoglycan-based cell wall
                     biogenesis [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
BASE COUNT         6984 a         3258 c         4433 g         6621 t
ORIGIN      
        1 aagattatac cacattgtgt actatattat attgaaacta gaatagtaca catctgcttc
       61 taaaatattg ttagaaaacg atttgactgt cctgatcaat ttgtcatgtt cttatttcat
      121 tttactatat ttttggttcg cgggaagtct actaagatac ttaaagatgc agatagtgaa
      181 aataaaggtg tagacattac cgtaaaaaag tgatataatc gtatgatgtt caatgtatag
      241 gtgttaatca tgagtagacg ttttaaaaaa tcaagttcac agaaagtgaa gcgaagtgtt
      301 aatatagttt tgctgactat ttatttattg ttagtttgtt ttttattatt cttaatcttt
      361 aagtacaata tccttgcttt tagatatctt aatctagtgg taactgcgtt agtcctacta
      421 gttgccttgg tagggctact cttgattatc tataaaaaag ctgaaaaatt tactattttt
      481 ctgttggtgt tctctatcct tgtcagctct gtgtcgctct ttgcagtaca gcagtttgtt
      541 ggactgacca atcgtttaaa tgcgacttct aattactcag aatattcaat cagtgtcgct
      601 gttttagcag atagtgagat cgaaaatgtt acgcaactga cgagtgtgac agcaccgact
      661 gggactgata atgaaaatat tcaaaaacta ctagctgata tcaagtcaag tcagaatacc
      721 gatttgacga tcgaccagag ttcgtcttac ttggcagctt ataagagttt gattgcaggg
      781 gagactaagg ccattgtctt aaatagtgtc tttgaaaata tcatcgagtc agagtatcca
      841 gactatgcat cgaagataaa aaagatttat accaagggat tcactaaaaa agtagaagct
      901 cctaagacgt ctaagaatca gtctttcaat atctatgtta gtggaattga cacctatggc
      961 cctattagtt cggtgtcgcg atcagatgtc aatatcctga tgactgtcaa tcgagatacc
     1021 aagaaaatcc tcttgaccac aacgccacgt gatgcctatg taccaatcgc agatggtgga
     1081 aataatcaaa aagataaatt aacccatgcg ggcatttatg gagttgattc gtccattcac
     1141 accttagaaa atctctatgg agtggatatc aattactatg tgcgattgaa cttcacttct
     1201 ttcttgaaaa tgattgactt attgggaggg gtagatgttc ataatgatca agagttttca
     1261 gctctacatg ggaagttcca tttcccagta gggaatgtcc atctagactc tgagcaggct
     1321 ctaggttttg tacgtgaacg ctactcacta gccgatggag accgtgaccg tggtcgcaac
     1381 caacaaaagg tgattgtggc tatccttcaa aaattaacgt caaccgaagc actgaaaaat
     1441 tatagtacga tcattaatag cttgcaagat tctatccaaa caaatatgcc acttgagact
     1501 atgataaatt tggtcaatgc tcagttagaa agtggaggga attataaagt aaattctcaa
     1561 gatttaaaag ggacaggtcg gacggatctt ccttcttatg caatgccaga cagtaacctc
     1621 tatgtgttgg aaatagatga tagtagttta gctgtagtta aagcagctat acaggatgtg
     1681 atggagggta gatgaaatga tagacatcca ttcgcatatc gtttttgatg tagatgacgg
     1741 tcccaagtca agagaggaaa gcaaggctct cttggcagaa tcctacaggc aaggggtacg
     1801 aatcattgtc tctacctctc accgtcgcaa gggcatgttt gaaactccgg aagagaagat
     1861 agcagaaaac tttcttcagg ttcgggaaat agctaaggaa gtggcgagtg acttggtcat
     1921 tgcttacgga gctgaaattt actacacacc agatgttctg gataagctgg aaaaaaagcg
     1981 gattccgacc ctcaatgata gtcgttatgc cttgatagag tttagtatga acactcctta
     2041 tcgcgatatt catagcgcct tgagcaagat cttgatgttg ggaattactc cagtcattgc
     2101 ccacattgag cgctatgatg ctcttgaaaa taatgaaaaa cgcgttcgag aactgatcga
     2161 tatgggctgt tacacgcaag taaatagttc acatgtcctc aaacccaaac tttttggcga
     2221 acgttataaa ttcatgaaaa aaagagctca gtatttttta gagcaggatt tggttcatgt
     2281 cattgcaagt gatatgcaca atctagacgg tagacctcct catatggcag aagcatatga
     2341 ccttgttacc caaaaatacg gagaagcgaa ggctcaggaa ctttttatag acaatcctcg
     2401 aaaaattgta atggatcaac taatttagga gaaatgatga aagaacaaaa cacgatagaa
     2461 atcgatgtat ttcaattatt taaaaccttg tggaaacgca agctaatgat tttaatagtg
     2521 gcacttgtga caggtgcggg ggcttttgca tatagcactt ttattgttaa gccagaatat
     2581 acgagtacca cgcgaattta cgtagtgaat cgcgatcaag gagacaagcc ggggctgaca
     2641 aatcaggatt tgcaggcagg atcttatctg gtaaaagact accgtgagat tatcctttcg
     2701 cagaatgtat tggaaaaagt agcgacaaat ttgaagttgg atatgccaac aaaaacgtta
     2761 gccagcaaag ttaaagtgac tgtaccaact gacactcgta tcgtctcaat ctctgtcaaa
     2821 gataaacaac cagaagaagc cagtcgtatc gctaattctc tacgagaagt tgctgcagaa
     2881 aagatcgtcg ctgtaacgcg agtatctgat gtaacgacac ttgaagaagc gcgaccagct
     2941 acgactccct cttctccaaa tgttcgacgc aattccttgt ttggttttct tggaggagca
     3001 gtcgtaacag taattgctgt tcttttgatt gagttgctcg acacccgtgt gaaacgtcct
     3061 gaagatgtcg aagatgtact gcaaattcca cttttagggg tcgttccaga tttgaacaaa
     3121 atgaaatagg aggaagttat gccaacatta gaaatctcac aggcaaaatt ggattttgta
     3181 aaaaaggcag aggaatatta taacgctttg tgcacgaacc tacagttaag tggagatgat
     3241 ttgaaagtat tttctatcac ttctgtgaaa ctaggagaag gaaaatcaac gacttccacc
     3301 aatatcgctt gggcttttgc gcatgcaggt tacaaaacgc tgctgattga tggagatatt
     3361 cgcaattctg ttatgttagg tgtctttaaa gcaagggata agattacagg cctgacagaa
     3421 tttttatcag gaactacaga cctatcacaa gggctttgtg ataccaatgt cgaaaatctc
     3481 tttgtaattc aggctggctc tgtgtcaccg aatccgacag ctcttcttca aagtaagaat
     3541 ttcagtacaa tgcttgaaac cttgcgtaaa tattttgact acatcattgt agatactgct
     3601 cctgtcggtg tcgtgattga tgcggctatt attacgcgaa aatgcgatgc ttctatttta
     3661 gtgacggagg taggtgaaat aaatcgacgg gatattcaaa aagcaaaaga acagttggaa
     3721 cacacaggaa agccgttttt gggagttgtg ttgaataaat tcgatacttc agtagacaaa
     3781 tacggttctt atggaaatta tggagattac gggaaaaata aaaaataggt cgggggatta
     3841 gagatgaatg gaaaaatagt aaagtcttca ttggccataa tccagagttt tcttgttatt
     3901 ttattgactt atctacttag tgctgtgaga gaagcggaga ttgtttcaac aacagctatt
     3961 gcactttata tcctccatta ttttgtcttt tatatcagtg attatggaca ggatttcttt
     4021 aaaagaggat atttgattga acttgtccag acattgaaat atatcctatt ctttgcacta
     4081 gcgattagta tttctaattt tttcttagag gatcgattta gtatttccag acgaggcatg
     4141 atttacttcc tcacattaca tgctctctta gtctatgtgc taaacctatt tatcaagtgg
     4201 tattggaagc gggcttatcc caactttaaa ggaagtaaga agattctcct acttacagca
     4261 acttctcgtg tcgaaaaggt actggataga ttaatagaat caaatgaggt tgttggggag
     4321 ttggtagccg tcagtgtctt agataaacca gattttcagc atgattgttt aaaggtagta
     4381 gcagaggggg agatagtaaa ctttgcgact catgaggtgg tcgatgaagt ctttatcaat
     4441 cttccaagtg aaaaatacaa tattggagag cttgtctctc agtttgaaac gatgggaatt
     4501 gatgtaacag ttaatctaaa tgcttttgat cgtagtttgg cacgtaacaa gcaaattcgt
     4561 gagatggcag gattaaacgt tgtgactttt tctacaacat tttataagac tagtcatgta
     4621 attgctaagc ggattattga tatcatgggt gcattggtag ggctgatact atgtggttta
     4681 gtcagtattg tactggttcc tttgattcga aaggatgggg gctctgctat ttttgctcag
     4741 acgcgtatag gaaaaaatgg tcgtcagttc actttttata agtttcgctc tatgtgtgta
     4801 gatgccgagg cgaaaaaaag agaactcatg gaacaaaata ccatgcaggg tggaatgttt
     4861 aaggtggacg atgatcctcg tatcacgaaa attggttgtt ttatacggaa gactagcttg
     4921 gacgagctac cacagtttta taatgttcta aagggagata tgagtttggt tggcacacgg
     4981 ccaccaacag tggacgagta tgagcactat accccagaac aaaagcgtcg tctgagtttt
     5041 aaacctggca taacagggtt atggcaggtc agcggacgaa gtgagattaa gaattttgat
     5101 gaagttgtca aattagatgt agcctatata gacgattgga caatttggaa agatattgaa
     5161 attttattga agacagttaa agttgtattg atgaaggatg gagcgaagtg atttttgccc
     5221 ttcggtcttg ttaggagaga tatgaaacag tcagtttata tcattggttc aaaggggatt
     5281 cctgccaagt atggaggatt tgaaaccttt gttgagaaat taacagaata tcaaaaagat
     5341 ggtaacatcc aatactatgt tgcttgcatg cgcgaaaatt ctgcaaagtc aggatttaca
     5401 gcagacacat ttgagtacaa cggtgctatt tgttacaaca ttgatgtgcc taatattggt
     5461 cctgctagag ccattgctta cgatattgca gcggtcaata aggctattga attgtctaag
     5521 ggaaacaagg acgaggctcc cattttttac attctagctt gtcgtatcgg accttttatt
     5581 tctggactta agaaaaaaat tcgttcgatc ggaggccgtt tgctggtaaa tccagatggt
     5641 catgagtggc ttcgagctaa atggagcttg ccagttcgga agtattggaa attttcggaa
     5701 cagttgatgg tcaaacatgc agatttatta gtctgcgata gcaaaaatat cgaaaaatat
     5761 attcgagagg actataaaca gtatcagccc aagacgacct atatcgctta tggtacagat
     5821 actacccctt caagtctgaa atcagaagat gccaaagttc gaaactggta tcgtgaaaag
     5881 ggagtaagcg aaaatggcta ttatctagtg gtgggacgat tcgttcccga aaacaactat
     5941 gaaaccatga ttcgtgaatt tatcaagtct aagtccaata aggactttgt ccttattaca
     6001 aatgtggaac agaataaatt ttacgatcag ttgctcaagg aaacaggttt cgacaaggat
     6061 ctaagagtca aatttgtggg aacagtctat gaccaagaat tgctcaagta tatccgtgaa
     6121 aatgctttcg cctatttcca tggacatgaa gttgggggta ccaatccatc gcttcttgaa
     6181 gctttagcat ccactaaact caacttgttg ttggatgtcg gctttaaccg tgaagttggt
     6241 gaagacggag ccatttattg gaaaaaagat gagctagcgc atgtaatcga agaagtggaa
     6301 cgatttgatg aaggtgatat tacggaatta gacgaaaagt ctagccaacg aattgcggat
     6361 gcatttacgt gggaaaagat tgtgtcagat tatgaggaag tgtttactgt atgaaaattt
     6421 tgcattatac tttaggcttt caaccatcac gtacaggtgg tcttgtcaag tatgctgagg
     6481 atttgatgac tcaacaagct acagatggac atgaagtaat cgcattatat ccaggagaaa
     6541 tctcaattat atttaggcag gttagaataa aaaaagcaga gaatcgaaaa ttccaatgct
     6601 ataaaataat aaacagccta cccttggctc tatttggtgg tatttcagaa ccagatgaat
     6661 ttatgaagag ttgtgataaa gcttcttata ggaaattttt gaaaaatatt aaggtagatg
     6721 taattcacat tcactcgctt ataggattac ataaggaatt tattgaagtt gcaaaagaat
     6781 taggaattaa aactgtattt acaagccatg attattatgg tttagcgcca gttccgcatt
     6841 tttattttaa cggagtagat tatagtagta ataatactaa tttagcatgg aacatcatgt
     6901 cctctaatgc tcttagtgta aaaaaacttc gattctttca agtctctttt tacccaacaa
     6961 ttcggaaatt gatgaaaatg cttgggaaaa atccaaagtc caagaaaaac ttagtaattc
     7021 gtgatatcac ggaggctatt gattatagtg ctctccgctc ttattataaa gcaatgtttg
     7081 ggttaataga tgcttacctt ttcaatagtc agttagctaa ggaagtttat gaagctaatc
     7141 atataatacc taaaaacaat atcatagtgt ccatttctaa cagctcaata agtaatcata
     7201 atattcgtgt tagttccggt gagaaaacag tggtagctta tattgggcct gatgaggaat
     7261 ataaggggta ttttgatttt ctagatatag ttaatgattt agatcaggaa aagtatgata
     7321 ttaaaacata tggacatttt ccaaatgaag attgtccacc ttatatccaa cagaacggtt
     7381 atttcacaaa agacacggtt ggaagcgttt attccaatat agatattttg attgtgccga
     7441 gtaggtggaa ggaaacattt ggtttgatta gtatagaggc gctatcgtat gatgtgaatg
     7501 tttttgtgag caaaaatgtg ggctctaaag atttggtttc agaagaacat atctttcata
     7561 ataaagacga tttgttaaaa aaaattcaat atgtaaaatt cgagaatgta aaattcaaaa
     7621 cgatgaaaga gcatatggtg gagattataa attactatga aaggattaca aatgataatc
     7681 aaaagattaa ttaagacaat tacaggtaaa gaaattgatc ttcaccctga tatcccaata
     7741 acttacattc ttcagagagg ttttcaatac ggtttgggtc ttagtcgagg gttgttacgt
     7801 ggtattggtc taggaaaaaa aggcaaacga ttatttattg gacgtggggt aacccttctc
     7861 gcaaaacgca agttatatgt tggaaacaat atccgaatcg gcaaatatgt gagcatagat
     7921 tgcctttcaa aggatgggat ccaaattgcg gataatgtta agataggaga ttactcgcaa
     7981 ataattggta caggttcagt aaaaaatatg ggtattgggc tcaaaattgg aaagaactct
     8041 tctttctcag aatatagttt attcggttct gcaggtggga ttactatcgg aggagatgtt
     8101 attgctggac aaaatgtacg ttttcatgct gagaatcata gctacgaagt gttgcatata
     8161 ccaatcagag agcaaggtgt taatcgtaaa gggatatccg ttggtgacaa ttgctggatt
     8221 ggggcaggag ctgttttttt agatggatct agtatcggtt caggttgtat cgttgcaacg
     8281 aatgcggttg ttactaagaa atttccagat aatgtaatta ttggtggagt gccagctaaa
     8341 attttaatgg aaagaaagta gtattaaatt aattgtataa atggagggaa atgatatgtc
     8401 taaaatgaag attgctgtag ttgggacagg ttatgttggt ttatccattt ctgtgttact
     8461 tgcacaacac catcatgtag tagcagtaga tattgtaaaa gagaaagtag aattaattaa
     8521 taaaagaatt tcacctattc aggatgattt tattgaaaga tatctttcag aaagtaattt
     8581 agatttagtt gcaacaatag acgctgaaac agcttataaa gatgcctctt ttatcgtagt
     8641 agcgacacca acaaattatg acttagaaag aaattttttt gatacatcaa cagttgaatc
     8701 ggtcattcaa caagttcaga atatgaattc tacagcaact atagtaataa aatcaacagt
     8761 ccccgtgggc tttaccgatt caattcgtaa aaaattagga atttcaaatc ttctattcag
     8821 tcctgaattt ttgcgtgaat caagggcact ttatgataac ttatatccaa gtcggatcat
     8881 agttggaaca gatttaagta atcaaaaatt agttgaaaaa gcccaagttt tctctaatct
     8941 tttagtgcaa ggtgccatta aaaaagatat ccctatttta actatgggat ttactgaagc
     9001 tgaagcagtt aaattatttg ctaataccta cttagcattg cgggtatcat attttaatga
     9061 attagatact tatgcagaga tcaaagggtt agatactcaa aaaataattg aaggtgttag
     9121 tttagatcct cgtatcggaa cccattataa taatccgagc tttgggtatg gtggatattg
     9181 cttaccaaag gatactaagc aacttttagc caattataag aatgtcccag aagagcttat
     9241 tggagctata gtacgaagca atacaacacg taaagatttt attgctaatc aagttcttaa
     9301 agtggtgaat tataatatac cagaagacga tattcctact aaacagatgg agaaagaagt
     9361 tgttattgga atataccgat taactatgaa aagtaacagt gataactttc gtcagagttc
     9421 aatacaagga gttatgaaac gtattaagga tagaggagtt aaagtaatca tttttgagcc
     9481 tactctaaaa gatagtgata cattctttgg aaacgctgtt ataaatgatt tagaagagtt
     9541 caaagtaaag tgtgatgtga ttattgcaaa tcgttatgat gaaacgttga atgacgttaa
     9601 ggataaagta tatacacgag atatttttag aagagattga taaaaatatg aaaaaagtat
     9661 taattgttcg aagtggacct taccaagtca atccggaagg atataatctt caagaacttg
     9721 gtttagcctc cgctatcagt cagcaaggct accagtgtga tgtcatgtat tatcacaaaa
     9781 caaagaacta tgatcaatta tatgagaaaa atggggaaca aattaaaata ttctggagga
     9841 ggggaataag attatttaga agtggaattt atccccagat tttaagagag aaatttttga
     9901 atcagtatga taagataatt atttctgagt acagccagat tatggcagtt ttattgtcta
     9961 gaattcattc caatgtatat atttataatg gcccatacta taatctattt aagattccca
    10021 ttattgaacc tatatacgat tttctttttg tagaaatgct caataagaga accaaaacag
    10081 ttttctgcaa gacagaaaaa gcagagtgtt atcttaaaaa caaaggattc aatgattgta
    10141 aagtagtggg cgtaggtcta gatattgaga agtttgaaca agaagaggaa cctacagagg
    10201 atactataga gcttttaaga agaatggaga ataaacaaaa tattctttat gtaggttcac
    10261 tatcaaaaag aaaaaacaca gctcagttaa ttagaatttt taatatttta aaatctaaaa
    10321 gtggtaagaa aaatgaactt caattggtat tgattggtaa ggatgaggat aatattgttg
    10381 aaaaaattaa ctattcacgg tttaaagatg atattattta tcaaccttat ttaaagaatt
    10441 ctcagcttca atttatttac ccatcatcac aactacttgt gctcccgtca gttcaagaga
    10501 tttttggtat ggtattactt gaggcaatgt attttaagtt gcctgttgtt tccagtgcaa
    10561 gtgctggagg agagacactg attcaagatg gtataaacgg taaaattgtg aatgatttta
    10621 atgatgaaca ctgggtggat tgtatagaaa atctattaaa taacccattg gaattgaaac
    10681 ggcttggaga atgtgctcat aagcgcatta cggaacagtt tatgtggtct tcaattgcga
    10741 gaaaaataat tgagacattt gatgaaaggt aagacttgct atgaattttt gttttgtgat
    10801 tttgcattat cgtaccagca atgacactat agagtgtatc aaatcgattc aaaagcttga
    10861 gggagattat aaaattgtaa ttgttgataa tgcttctcaa aatggcagta tagaaagggt
    10921 agaagcctta tttgcaaata atgacgagat agttataata aaaaacacga aaaacttagg
    10981 atttgctgct ggaaataata ttggatacgc ctacgctagg actcaaataa aagctgatat
    11041 gattgctgta cttaataatg atattgttat taagcaaaaa gatttcatca atcgtatatt
    11101 tgaactctat agaaattctc agtttcatat cgctggtcca gacattgtct ctcttgtaga
    11161 tggtcatcat caaagtcctg ttgttgagaa gattaattct atatctaagg ctaataaaga
    11221 actttttaaa tatagaatct tgaggattat taataaaata ggattatatg agctgatgac
    11281 tagacagcca aaaaaagaat taaatagaat aagtgttgca gaccctatga gatatcagga
    11341 aaatgttatt ttacatggga gttttgtaat tttttcaccg ttgtatgttt cagaggagga
    11401 gtgtgctttc agaccggata cattcatgta tatggaagag cctattctat atgaatattg
    11461 catgcttaaa aattataaga cagtatttga tccttctatt gtaatttatc ataaagagga
    11521 ctcatcaaca aattcgttgt ataatgcagc atatgcaaaa agagagtttg tttttaaaaa
    11581 tatgattaga tctctaaaga tttatagaag tctattgaag tagtaaacta aggaaaggat
    11641 aataattaga aattgaatct tagtatgtta gccttgacaa taggaacagt ggtatttgtt
    11701 aaaaaaacgt ataggacgtt tctcaatccc ataattttat ttgtaatttt gtggtttatt
    11761 ataacaactt tgtcaagttt aaaactattc caacttttcg agattagtac tcacacacaa
    11821 caaattattt tgcttgggac ttctctattt gttatagggg gagggatagc aatttggttt
    11881 cgggataaat tttattttaa agttggcggt aactcatatt ttacaacaga ctttgaaatt
    11941 aattataatt tgttcttttt gctaggtatc atttgccttt tctattattt gccagatttc
    12001 ttttcctcac tggtatcatt aataagaggt gggaatttaa acttagttag acaatctgcg
    12061 caggatgcag tagataccag tggattaaag aatttcattg gaacatttat tgttagtcct
    12121 agtgccatgg tattagaaat attaggagta ttagatttct ggagcaataa aaaaggtaga
    12181 aaactatttt atcttagttt agctgtcatt tttgtaagag ttattgcaga tgctggtaga
    12241 acacctctat ttaatgttgt catatattta ttacttactg ttttagcaaa taggttctct
    12301 gaaaaaactg aaaagaagag aaaagttagt aaaattaaga tagtaaatta tggtatgcta
    12361 ggttcaatta tcttatggct atcaacttta tctaggacaa caacctccgt ttataggatt
    12421 ctttattttt atttcgcaat gtccccaata ttattagaaa agtggagtag tgtacttgat
    12481 tctgaaaaat tagtaacaaa gggtttggtt tcgttgaacg gtttcttttt ttcaatctca
    12541 tatgtactta aaaatctgtt tagaatagat tattcgcaaa gagtattaga agcatacaca
    12601 atgattgcga atactgatgc aatctggtat aatattgcac ctggtttgac caaggcaaat
    12661 gcatatgtct ctctgttttg gttcttttat gcggatggac gtttactagg agttttaata
    12721 ggatcccttc tatatggtac cttttgtggt tatatctttt gcaggtatat ccagcaacaa
    12781 aataaaaaga atttggctat gttactattt atttatcaag gtgttttttt ctcttttatt
    12841 agatttccgt tttcaaaatc aaattatgca attgcattcg tactcttatt attttttgct
    12901 tttaagaaga aaggaataga gaaaagtgtt taatatcaat gaccagtcta ttatttatgt
    12961 tgcatgtcct tattttaata aaacaggtgg aacggagctt gtccatcaat tagtttattc
    13021 tattaatcat tttgggggga aagctatcgt tgcttattat ggtagtgaaa gtgctccaaa
    13081 taaggtgaat cctgcgttta gagaatatgt ttctacgttt gttgatataa aagatgttat
    13141 tgactctctt gataatatta ttattttacc ggaaattaat ccggatttag ctgctaatct
    13201 agagtctatt caaaaagcag tatggtggat gagcgttgac aattatttga agcgtaatgg
    13261 tattttaggt tccttggaac attttggact tttacgaaca attaaattat ttgtaaaagg
    13321 aaatattaaa ataggtggat atagaataga taaagagatt ccccatcttt atcaaagtga
    13381 atacgccaag caatttcttc tagctaaagg tgtcaaaaag tactatagat tgtctgatta
    13441 tttaaacgag tcttatattc agcgatctat ttcaacagac actaaaaaag atgttattct
    13501 ttacaatcct aaaaaaggga ttgaatttac tcgtgagcta attaaacagg ctccagaatt
    13561 aacgttctct ccaattgaga atatgtcaac tgaacaggtg aaaaaattac tttcaaaaag
    13621 caaagtatat attgattttg gcaaccatcc tgggaaagat agattcccac gggaggcagc
    13681 gatatcaggt tgttgtgtga taactgggaa acgaggttct gcaaaatatt ataaggatat
    13741 tcctattcca gattcataca aatttgaaga cactgttgaa aatatcccca acattattga
    13801 gaccctgaaa tcatgcttaa aaaattatga caaacatact gttgactttg agaaatatca
    13861 acaatatatt aaatctgaac atgatttatt tgaaagagat gtgaaagaat tattcactag
    13921 gaataggggt taaggttatg tcaaccagaa attcacttat taaaaattct ctttataatg
    13981 ttgcttatag aatgttaaat atcatatttc cattagtatc cgcaacatat actgcacgga
    14041 taattttagc tagtggagtt ggggaggtct cgtttgcaca aaatgttgtt tcttacttta
    14101 caacgatagc tgctatgggt attccaaatt atggtatacg agaaattgct aaaactagaa
    14161 ataaagcaga ggctacgaat aaagtttttt cagagctatt tctgattaat ggattgtcta
    14221 cattactgtg ttctatagta tatttaattc tgattttgac attcaatagc atttttgata
    14281 atacatcaat gtatcttgct gtgggtttaa cattagtgtt taacttcctt aatatcgatt
    14341 ggttctatca aggaaaagag gactatgcat acatcacgaa acgtagtttc agtataaaac
    14401 ttatttctct ttttagttta tttatttttg ttagagatac tgacgatgca gttaactatg
    14461 cattgatttc tagcttagca attggcggga ataatatttt taatcttgtt aatttaagga
    14521 aatataatat tagatttagt tttaataata ttaagattag aagacactta aaacctattt
    14581 ttgttttgtt gggttcagtg attgctattg aaatctatac tatgctggat accactatga
    14641 ttggtgctat ggtaggaacg actgaggtag gttattatac aaattctatg aagctagtta
    14701 aattgctgat aactgtgatt accgctattg gaggagtgct tttaccacga ctaagtgatt
    14761 attattctaa gggagaattt gaaaaattaa atcacatcgt tgataaagtt tttagaatca
    14821 tgttgtttct ttttttacca gcccaagttg cattaattct agttgcacca gtaattatgc
    14881 cgattttatt tggtgatagt tttataccag cagtgttaac acttcaactt acttctttgc
    14941 ttatatgtac attagggttt agtaatttat ttgggactca aatattacta acatttggag
    15001 atgagcgaaa gcttttgatt agcacaattt taggagcgct tagtaatatc gctttgaacc
    15061 taattctgat tccagtaatg gctcaaaatg gagcagcgtt ggcatctgtg attagtgaaa
    15121 caattgttac tttaacagca tactactatg cgaaaaaacg tgtgacaatt aggtttgact
    15181 taggatttta tttgccaact gttgtttcaa caataatcat gggtggagct atatatgtag
    15241 taatgcaatt gtatattggg gatatagaaa aaatgttatt ttcaactttg ttaggaggtg
    15301 ttgtattcct tttaattaac gtttttatga agaatcctat tatatatgaa tttacaggta
    15361 ttataaagag aaagagataa ttatgtacga ctatttaatc gttggagcgg gtttgtctgg
    15421 agcaatcttc gcacacgaag ctacaaagcg tggaaaaaaa gtaaaagtga ttgataaacg
    15481 cgatcacatt ggagggaaca tatactgtga gaatgtagaa ggtatcaatg ttcataaata
    15541 tggtgcccat atcttccata cttctaataa aaaagtctgg gactacgtca atcaatttgc
    15601 tgagtttaac aactatatca actcacctgt cgcaaactat aagggaagtc tttataacct
    15661 tcctttcaat atgaatacct tctatgctat gtggggcaca aaaactccac aagaagtgaa
    15721 ggataagatt gctgagcaga cagctggtat gaaggatgtt gagccgaaaa atctggaaga
    15781 acaagctatc aagttgattg gtccggatat ctatgaaaag ttgatcaagg gttatacaga
    15841 aaagcaatgg ggacgctcag cgatagaact tcctccattt atcataaaac gccttccagt
    15901 tcgtttaacc tttgataata actattttaa tgaccgttac caagggattc ctattggtgg
    15961 ttacaatgtc atcatcgaaa atatgctgaa agatgtagaa gttgaacttg gagtagactt
    16021 ttttgctcat cgtgaagagt tggaagcatc tgctaacaaa gttgtcttca caggaatgat
    16081 cgaccaatat tttgactaca agcacggaga gttagaatac cgtagccttc gttttgagca
    16141 tgagatttta gacgaggaaa attatcaagg gaatgctgta gtgaactata cagagcgtga
    16201 gatcccttat actcgtatca tcgaacacaa acattttgaa tatggaatgc agccaaagac
    16261 agttatcacg catgaatatc cagctgactg gaagcgtggg gacgagccct actatcctat
    16321 taacgatgag aaaaataatg ctatgtttgc taaataccaa gaagaagcag cgcagaatga
    16381 taaagttatc ttttgtgggc gtttagcaga ttataagtat tacgatatgc atgtggtgat
    16441 tgaacgggcg cttgaggttg tggagaaaga atttagtaat tgaaaaacaa cgaagaaagg
    16501 ttgcttatta tgaaaggtat tattctagca ggtggttcgg gaactcgctt gtatcctttg
    16561 actcgagccg catcaaaaca acttatgccg gtttatgata aaccgatgat ttactaccca
    16621 ctttcaacat taatgttggc tgggattagg gatattttga ttatctcaac tcctcaagat
    16681 ttgcctcgtt ttaaagagct tcttcaagat ggttccgagt ttggtattaa actttcttat
    16741 gctgagcaac caagtccaga tggtttggca caagccttta tcattgggga agagtttatt
    16801 tctgatgata gcgttgcgct aatcttaggt gataatatct accatggttc tgggctttcc
    16861 aagatgctac aaaaggcagc gagtaaggag tcgggagcaa ctgtttttgg ctaccatgtc
    16921 aaggatccag agcgctttgg tgtggttgag tttgatcagg atatgaaggc tatttctatt
    16981 gaagaaaagc cagagcaacc tcgttcaaac tatgcagtta caggtctcta tttctatgat
    17041 aatgatgtag tagagattgc caagagtatt aaaccaagtc ctcgtggtga actggaaatt
    17101 acagatgtaa acaaagctta cctagatcgt ggtgatttgt ctgttgagct tatgggacgt
    17161 ggctttgctt ggctggatac tggaactcat gaaagtttac tagaggcttc acagtacatc
    17221 gaaacagtcc aacggatgca aaatgttcag gtagcaaact tagaagaaat tgcctatcgc
    17281 atgggttata tcagtcgtga agatgtattg accttagccc aaccacttaa gaaaaatgaa
    17341 tacggacagt atctgctccg tttgattgga gaagcataga tgacagataa ttttttcggt
    17401 aagacgcttg cggcacgcaa ggttgaagct attccaggca tgttggagtt tgatatcccc
    17461 gttcatggag ataatcgtgg ctggtttaaa gaaaatttcc aaaaggaaaa aatgcttcca
    17521 cttggatttc cagagtcttt ctttgcagaa ggaaaattgc aaaacaatgt atccttctca
    17581 cgtaaaaatg tccttcgagg actccacgca gagccttggg ataagtacat ctctgtagca
    17641 gatggaggga aagttctggg ttcttgggtt gatctacgcg agggtgaaac ctttgggaat
    17701 acctatcaga cagtaattga tgcaagcaag ggaatctttg ttcctcgagg cgtagctaat
    17761 ggcttccaag ttctatcaga tacagtgtca tatagctatc tggtcaatga ttactgggct
    17821 ctcgagctca aacccaagta tgcctttgtg aactacgctg atccaagcct tggtattgaa
    17881 tgggaaaata ttgcagaagc agaggtttca gaagcagata aacatcatcc cctacttaag
    17941 gatgtaaaac ctttgaaaaa agaagatttg taaaaaggaa agaatatgac tgaatacaaa
    18001 aatattatcg tgacaggtgg agctggcttt atcggttcta actttgtcca ttatgtttac
    18061 gagaactttc caggtgttca cgtgacagtc ctagataagt tgacttatgc tggaaatcgc
    18121 gcgaatattg aggaaatttt aggtaatcgt gttgagttag ttgttggtga cattgctgat
    18181 gcggagttgg tagacaagtt ggctgctcaa gcagatgcta tcgttcatta tgcagcggaa
    18241 agccacaatg ataattcgct caatgatcca tcgccattta ttcatactaa cttcatcgga
    18301 acctatactc ttttagaagc tgctcgtaag tatgatattc gcttccacca tgtatcgaca
    18361 gatgaagttt atggggatct ccctttacgc gaagatttgc caggtcatgg tgaaggacca
    18421 ggtgagaaat ttactgctga aacaaaatac aacccaagct ctccgtactc atcaaccaag
    18481 gcagcctcag atttgattgt caaagcctgg gtgcgttctt ttggagtcaa ggcaacgatt
    18541 tccaactgtt caaataacta cggtccttat caacatatcg aaaaattcat cccacgtcag
    18601 attactaaca tcctaagtgg aattaagcca aaactttacg gtgaaggtaa gaatgttcgt
    18661 gactggattc ataccaatga ccattcttca ggagtttgga caatcttgac aaaagggcaa
    18721 atcggtgaaa cctacttgat tggggctgat ggtgagaaga acaataagga agttttggaa
    18781 cttatcctta aggaaatggg acaagctacg gatgcctatg atcatgtgac tgaccgtgca
    18841 ggacatgacc ttcgctatgc gattgatgcc agcaagctcc gtgatgagtt ggggtggaaa
    18901 cctgaattta ccaactttga agctgggctc aaggcaacaa tcaagtggta tacagataac
    18961 caagaatggt ggaaagcaga aaaagaagct gttgaagcca attatgctaa gactcaggag
    19021 attattacag tataaaaagc aggaaatagc tgctttttat tgctatattg agaagagtta
    19081 catattagaa aggtctagag atgattttaa ttacaggggc aaatggccaa ttaggaacgg
    19141 aacttcgcta tttattggat gaacgtaatg aagaatacgt ggcagtagat gtggctgaga
    19201 tggacattac caatgaagaa atggttgaga aagtttttga agaggtgaaa ccgactttag
    19261 tctaccactg tgcagcctac accgctgttg atgcagcaga ggatgaagga aaagagttgg
    19321 acttcgccat caatgtgacg gggacaaaaa atgtcgcaaa agcatctgaa aagcatggtg
    19381 caactctagt ttatatttct acggactatg tctttgacgg taagaaacca gttggacaag
    19441 agtgggaagt tgatgaccga ccagatccac agacagaata tggacgcact aagcgtatgg
    19501 gggaagagtt agttgagaag catgtgtcta atttctatat tatccgtact gcctgggtat
    19561 ttggaaatta tggcaaaaac ttcgttttta ccatgcaaaa tcttgcgaaa actcataaga
    19621 ctttaacagt tgtaaatgac cagtacggtc gtccgacttg gactcgtacc ttggctgagt
    19681 tcatgaccta cctagctgaa aatcgtaagg aatttggtta ttatcatttg tcaaatgatg
    19741 cgacagaaga cacaacatgg tatgattttg cagttgaaat tttgaaagat acagatgtcg
    19801 aagtcaagcc agtagattcc agtcaatttc cagccaaagc taaacgtccg ctaaactcaa
    19861 cgatgagcct ggccaaagcc aaagctactg gatttgttat tccaacttgg caagatgcat
    19921 tgcaagaatt ttacaaacaa gaagtgagat aagtagtaga atgattttct agtctaataa
    19981 aagaggcaga taatgaactc caaaggagct taagatgtac gattatcttg ttgttggtgc
    20041 agtctttgcc catgaagcag ccttagaagg aaaaaaagta aaagttattg aaaaacgaaa
    20101 tcatatcgcg ggtaatatct atactcgtga agaggaagga attcaagttc atcaatatgg
    20161 tgctcatatc ttccatactt ctgataagga gatctgggat tatgtaaatc agtttgcaga
    20221 gtttaaccgt tataccaatt ctcctgttgc aaactataag ggtgagattt ataaccttcc
    20281 ttttaatatg aataccttca ataaactctg gggagttgta acgccagcag aagtacaggc
    20341 taagattgat gaacaacgtg ctattttaaa tggtaaaact cctgaaaatt tggaagaaca
    20401 ggcgatttct cttgtaggta cagacatcta cgaaaaatta atcaaagact atacagagaa
    20461 acagtggggg caaaccaact actgaacttc catcctttat tattcgctgt ttaccagtac
    20521 acctgaccta tgataacaac tattttaacg atacctatca agggattcca attggtggat
    20581 acactcaaat agttgaaaaa tgttggatca tgaaaatatt gatgtagaaa caaatgttga
    20641 tttctttgtg aacaaagagc aatatctgaa agattttcct aagattgtct ttactggtat
    20701 gattgatgaa ttctttgact ataagttggg cgaactagag taccgtagtc ttcgttttga
    20761 aaatgagacc ttggatatgg aaaattacca aggaaatgca gttgtgaact atacggatgc
    20821 agaaacccca tatactcgca ttattgaaca caaacatttt gagtttggga gtcaagcaaa
    20881 gactatcatt actaatagaa cattctaaaa catgggaaaa aggtgatgag ccttattatc
    20941 cagttaataa tgatcgtaat aatcatttgt ataaatcata taaaaaactt gctgatgagc
    21001 aagggaatgt tatctttggt ggccgcttag gacactatcg ttattacgat atgcaccaag
    21061 taattggagc agctttgcag tgcgtgagaa atgagttaga ttcatactca atgaaaatta
    21121 aagagcaaac taggaagcta gccgcaggtt gctcaaaaca ctgttttgag gttgcagatg
    21181 gaagctgacg cggtttgaag agattttcga agagtataaa caagtaaaac tgactaccag
    21241 ttattattta gaaatagtat taaaaattcc ttgactatat gatatcccaa atcatt
//
LOCUS       DBMVGT010000029        19780 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.029, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000029 DBMVGT010000000
VERSION     DBMVGT010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 19780)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19780)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19780
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.029"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            148..6834
                     /gene="bgaA"
                     /locus_tag="AC0DU4_001192"
     CDS             148..6834
                     /gene="bgaA"
                     /locus_tag="AC0DU4_001192"
                     /EC_number="3.2.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000515226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored adhesin/beta-galactosidase BgaA"
                     /protein_id="HIN4237156.1"
                     /translation="MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVY
                     ADETLITHTAEKPKEEKMIVEEKADKALETKNVVERTEQSEPSSTEAIASEKKEDEAV
                     TPKEEKVSAKPEEKAPRIESQASSQEKPLKEDAKAVTNEEVNQMIEDRKVDFNQNWYF
                     KLNANSKEAIKPDADVSTWKKLDLPYDWSIFNDFDHESPAQNEGGQLNGGEAWYRKTF
                     KLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLHKDGRENVI
                     AVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHVEKNGTTILTPKLEEQQHGKVETHVT
                     SKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVERPKLW
                     TVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLH
                     HDHGALGAEENYKAEYRRLKQMKEMGVNSIRTTHNPASEQTLQIAAELGLLVQEEAFD
                     TWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFDLRTMVERGKNNPAIFMWSIGNEIG
                     EANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDAVGFNY
                     SEDNYKALRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDR
                     VGWGKTATASWTFDRDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIVDTAG
                     IPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENKELASKVADSEGKIPVRAYSNASSVE
                     LFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWKVAYQPGTLEAIARDESGKEI
                     ARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHG
                     QGQLVGVDNGEQASRERYKAQADGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLK
                     SSQVTVFTGKKEGQEKTVLGTEVPKVQTIIGEAPEMPTTVPFVYSDGSRAERPVTWSS
                     VDVSKPGIVTVKGMADGREVEARVEVIALKSELPVVKRIAPNTDLNSVDKSVSYVLTD
                     GSVEEYEVDKWEIAEEDKAKLAIPGSRIQATGYLEGQPIHATLVVEEGNPAAPAVPTV
                     TVGGEAVTGLTSQKPMQYRTLAYGAKLPEVTASAKNAAVTVLQASAANGMRASIFIQP
                     KDGGPLQTYAIQFLEEAPKIAHLSLQVEKADSLKEDQTVKLSVRAHYQDGTQAVLPAD
                     KVTFSTSGEGEVAIRKGMLELHKPGAVTLNAEYEGAKGQVELTIQANTEKKIAQSIRP
                     VNVVTDLHQEPSLPATVTVEYDKGFPKTHKVTWQAIPKEKLDSYQTFEVLGKVEGIDL
                     EARAKVSVEGIVSVEEVSVTTPIAEAPQLPESVRTYDSNGHVSSAKVAWDAIRPEQYA
                     KEGVFTVNGRLEGTQLTTKLHVRVSAQTEQGANISDQWTGSELPLAFASDSNPSDPVS
                     NVNDKLISYNNQPANRWTNWNRSNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVG
                     APKSYVIEYYVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHF
                     SFDKVETYAIRIRMVKADNKRGTSITEVQIFAKQVAAAKQGQTRIQVDGKDLANFNPD
                     LTDYYLESVDGKVPAVTANVSNNGLATVVPSVREGEPVRVIAKAENGDILGEYRLHFT
                     KDKNLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKDLTVEWEEVPAEN
                     LTKAGQFTVRGRVLGSNLVAEVTVRVTDKLGETLSDNPNYDENSNQAFASATNDIDKN
                     SHDRVDYLNDGDHSENRRWTNWSPTPSSNPEVSAGVIFRENGKIVERTVAQAKLHFFA
                     DSGTDAPSKLVLERYVGPGFEVPTYYSNYQAYESGHPFNNPENWEAVPYRADKDIAAG
                     DEINVTFKAVKAKAMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELA
                     DFAENRQDYQITYKGQRPKVSVEENNQVASTVVDSGEDSLPVLVRLVSESGKQVKEYR
                     IQLTKEKPVSAVQEDLPKLEFVEKDLAYKTVEKKDSTLYLGETRVEQEGKVGKERIFT
                     VINPDGSKEEKLREVVEVPTDRIVLVGTKPVAQEAKKPQVSEKADTKPIDSSEADQTN
                     KAQLPNTGSAASQAAVAAGLALLGLSAGLVVTKGKKED"
     gene            complement(7082..7219)
                     /locus_tag="AC0DU4_001193"
     CDS             complement(7082..7219)
                     /locus_tag="AC0DU4_001193"
                     /inference="COORDINATES: protein motif:HMM:NF025126.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HIN4237157.1"
                     /translation="MKPVFGQIKACLGYKRCNLRGKRQVRIDMGLVLMANNLLKHSEM
                     K"
     gene            complement(7216..7623)
                     /locus_tag="AC0DU4_001194"
     CDS             complement(7216..7623)
                     /locus_tag="AC0DU4_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237158.1"
                     /translation="MEENDREILRQTSRTDTGLFSRRNPPLLIKYAMFDKKQKRGHKQ
                     SAKNLANWHYNDKEDSYTHPDGWYYRFHHTKHQKTQTDFQQEIKVYYADEPESVPQKG
                     LYMNERYQNLKAKECQALLSPEGRQISLNARLM"
     gene            complement(7691..7936)
                     /locus_tag="AC0DU4_001195"
     CDS             complement(7691..7936)
                     /locus_tag="AC0DU4_001195"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237159.1"
                     /translation="MHIHYNTNQTTLPLEISSFLPQDHLVFTIEKVVNTLEEHHFYAF
                     YHAFDRPSYHLKMLVSTLLFAYSQGIFSGRKIEKWKS"
     gene            complement(8148..8507)
                     /locus_tag="AC0DU4_001196"
     CDS             complement(8148..8507)
                     /locus_tag="AC0DU4_001196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3397 domain-containing protein"
                     /protein_id="HIN4237160.1"
                     /translation="MGMILMKLASILLLILTLVVCIILTKLFRLKKLGRNFADLAFPV
                     LVFEYYLITAKTFTHNFLPRLGLALSILAIILVFFFLLKKLSFYYPKFIKFFWRAGFL
                     LTLIMYIEMIVELFLMK"
     gene            8599..9555
                     /locus_tag="AC0DU4_001197"
                     /pseudo
     CDS             8599..9555
                     /locus_tag="AC0DU4_001197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002881980.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein.; internal stop;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_function: GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
     gene            9539..10096
                     /locus_tag="AC0DU4_001198"
     CDS             9539..10096
                     /locus_tag="AC0DU4_001198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HIN4237161.1"
                     /translation="MKRPLEMAHDFLAEVVTKEDVVVDATMGNGHDTLFLAKLAKQVY
                     AFDIQKQALEKTQERLHQAGLTNAQLILQGHETLDQFVTKAKAGIFNLGYLPSADKSV
                     ITRPQTTIEALEKLCGLLVKGGRIAIMIYYGHEGGDLERDAVLDFVIQLNQQEYTAAI
                     YRTLNQVNNPPFLVMIEKLERYRHG"
     gene            10089..10343
                     /locus_tag="AC0DU4_001199"
     CDS             10089..10343
                     /locus_tag="AC0DU4_001199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237162.1"
                     /translation="MDKQYLHEKLDAMRQNFVESTHHERSVGVLDQAHMSKKMLKIKK
                     KLVALEMERCQRKIEHKDCSKIDQKIKEQKEIFESCCKKD"
     gene            10355..12409
                     /locus_tag="AC0DU4_001200"
     CDS             10355..12409
                     /locus_tag="AC0DU4_001200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000421632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015078 - proton transmembrane transporter
                     activity [Evidence IEA];
                     GO_function: GO:0015297 - antiporter activity [Evidence
                     IEA];
                     GO_process: GO:0006812 - monoatomic cation transport
                     [Evidence IEA];
                     GO_process: GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HIN4237163.1"
                     /translation="MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFL
                     PNTDFHLNTELFLALVIGPLLFREAEEADVTAILKHWRIIVYLIFPVIFISTLSLGGL
                     AHLLWFSLPLAACLAVGAALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLV
                     AFQVALTAWTTGAFSLGQASSSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIAS
                     ELLLELSLPLVTFFLAEEVHVSGIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHT
                     VTFMLNGSVFVILGMELEMIAEPILTNPIYNPLLLLLSLIALTFVLFVIRFIMIYGYY
                     AYRTRRLKKKLNKYMKDMFLLTFSGVKGTVSIATILLIPSNLEQEYPLLLFLVAGVTL
                     VSFLTGLLILPHLSDEEEESKDYLMHIAILNEVTLELEKELEDTRNKLPLYAAIDNYH
                     GRIENLILSQENQDDQEDWAALKLLILSIESDGLEQAYEEGNISNRAYRVYQRYLKNI
                     EQGINRKLASRLTYYFLVSLRILRFLLHEVFTLGKTFRSWKDKEQSRLRALDYDQIAE
                     LYLANTEMIIESLENLKGVYRRSLISFMQESRLRETTIISSGAFVERVINRVKPNNIN
                     EMLRGYYLERKLIFEYEEKRLITTKYAKKLRQNVNNLENYSLKEAANTLPYDMVELVR
                     RN"
     gene            12588..13448
                     /locus_tag="AC0DU4_001201"
     CDS             12588..13448
                     /locus_tag="AC0DU4_001201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HIN4237164.1"
                     /translation="MKKWWKELIDKPLLKAFLHYYQASDSELTSVAVAYYWLISIFPL
                     LLVVVNILPYFQIPVGEFLGFMKDVLPPSLYEGVEKIAREVLTQPSTGLLSFSVLSAL
                     WSFSKSINFLQKAFNKAYGVEKSRGLISHQMLSLLVSFGLQFLFAFALFLILFGQMIL
                     ALLAHYWTKDGIIYQALQGLAGPLIYALLFAILVMLYYFLPNLSNRKISYTLPGSAFV
                     LLVILGVLTLFSSYLNYYVHHLVDVRILGSVLLVVMMFWFILIAKIVILGAVINASMQ
                     SLKDQVFKKD"
     gene            13659..14369
                     /gene="ccdA2"
                     /locus_tag="AC0DU4_001202"
     CDS             13659..14369
                     /gene="ccdA2"
                     /locus_tag="AC0DU4_001202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000509848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HIN4237165.1"
                     /translation="MGHIFFFLSVFLAGILSFFSPCILPLLPVYTGVLLDDKDGAQAS
                     SGKFSISVTSLLRTLAFIAGISFIFILLGYGAGFLGDLLYASWFQYLTGAIIILLGLH
                     QMEILHFKGLYKEKRLQLQGQGQNGKGYSQAFLLGLTFSFAWTPCVGPVLGSVLALAA
                     SGGSGAWQGAGLMLVYTLGLALPFLLLALTSSYVLKHFRKLHPYLGILKKVGGFLIIV
                     MGFLVLFGNASILSQLFE"
     gene            14389..14955
                     /locus_tag="AC0DU4_001203"
     CDS             14389..14955
                     /locus_tag="AC0DU4_001203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin family protein"
                     /protein_id="HIN4237166.1"
                     /translation="MKKWQTCVLGAGSLLCLTACSGKSVTSEHQTKDEMKTEQTASKT
                     SAAKGKEVADFELMGVDGKTYRLSDYKGKKVYLKFWASWCSICLASLPDTDEIAKEAG
                     DDYVVLTVVSPGHKGEQSEADFKNWYKGLDYKNLPVLVDPSGKLLETYGVRSYPTQAF
                     IDKEGKLVKTHPGFMEKDAILQTLKELA"
     gene            14966..16078
                     /gene="msrB"
                     /locus_tag="AC0DU4_001204"
     CDS             14966..16078
                     /gene="msrB"
                     /locus_tag="AC0DU4_001204"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA];
                     GO_process: GO:0006979 - response to oxidative stress
                     [Evidence IEA];
                     GO_process: GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HIN4237167.1"
                     /translation="MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQ
                     GGKAVKKTEISKDADLHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYEL
                     INQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK
                     DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAY
                     PVIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEP
                     LFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGP
                     QDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD"
     gene            16346..17083
                     /locus_tag="AC0DU4_001205"
     CDS             16346..17083
                     /locus_tag="AC0DU4_001205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HIN4237168.1"
                     /translation="MTYTILIVEDEYLVRQGLTKLVNVAAYDMEIIGQAENGRQAWEL
                     IQKQVPDIILTDINMPHLNGIQLASLVRETYPQVHLVFLTGYDDFDYALSAVKLGVDD
                     YLLKPFSRQDIEEMLGKIKQKLDKEEKEEQLQDLLTNRFEGNMAQKIQSHLADSQFSL
                     KSLASDLGFSPTYLSSLIKKELGLPFQDYLVRERVKQAKLLLLTTDLKIYEIAEKVGF
                     EDMNYFTQRFKQIAGVTPRQFKKGEDR"
     gene            17080..18771
                     /locus_tag="AC0DU4_001206"
     CDS             17080..18771
                     /locus_tag="AC0DU4_001206"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cache domain-containing sensor histidine kinase"
                     /protein_id="HIN4237169.1"
                     /translation="MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGN
                     SQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENPSQDKVEGIRDLFLTILKSD
                     KDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW
                     VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQH
                     TVYSSSSKMEAMKPYIETGQGYTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQL
                     LWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAKEVGAYELR
                     EVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFH
                     DSQRVVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINEN
                     VAFDNLVLPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQD
                     AGDSSQSQLKRGGVGLQNVDQRLKLHFGANYQMKIDSRPQKGTKVEIYINRIETS"
     gene            18887..19450
                     /locus_tag="AC0DU4_001207"
     CDS             18887..19450
                     /locus_tag="AC0DU4_001207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001006373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01440 family protein"
                     /protein_id="HIN4237170.1"
                     /translation="MNETQIQRETRQVVEDVLEKTNLKQGALFVLGLSSSEVLGGQIG
                     KESSQEIGELIVETILGILGSRGIHLAVQGCEHVNRALVVERQVAEQFGLEIVSVHPT
                     LHAGGSGQLAAFKFMQDPVEVEFIKAHAGLDIGDTAIGMHVKHVQVPIRPILREIGHA
                     HVTALTSRPKLIGGARAHYPQDAIRKF"
     gene            19472..>19780
                     /locus_tag="AC0DU4_001208"
     CDS             19472..>19780
                     /locus_tag="AC0DU4_001208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473008.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HIN4237171.1"
                     /translation="MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEII
                     SQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKK
                     I"
BASE COUNT         5940 a         3734 c         4423 g         5683 t
ORIGIN      
        1 aatcatatct acggcaaggc gacactgacg aagtttgaat tggattttcg cagagtgtaa
       61 attgttgaaa ctaggttgtc ataccatgta taccacttgg gctttggtag tagctaactg
      121 cactaaatat aatataagga gggttttatg gggaaaggcc attggaatcg gaaaagagtt
      181 tatagcattc gtaagtttgc tgtgggagct tgctcagtaa tgattgggac ttgtgcagtt
      241 ctattaggag gaaatatagc tggagaatct gtagtttatg cggatgaaac acttattact
      301 catactgctg agaaacctaa agaggaaaaa atgatagtag aagaaaaggc tgataaagct
      361 ttggaaacta aaaatgtagt tgaaaggaca gaacaaagtg aacctagttc aactgaggct
      421 attgcatctg agaagaaaga agatgaagcc gtaactccaa aagaggaaaa agtgtctgct
      481 aaaccggaag aaaaagctcc aaggatagaa tcacaagctt caagtcaaga aaaaccgctc
      541 aaggaagatg ctaaagctgt aacaaatgaa gaagtgaatc aaatgattga agacaggaaa
      601 gtggatttta atcaaaattg gtactttaaa ctcaatgcaa attctaagga agccattaaa
      661 cctgatgcag acgtatctac gtggaaaaaa ttagatttac cgtatgactg gagtatcttt
      721 aacgatttcg atcatgaatc tcctgcacaa aatgaaggtg gacagctcaa cggtggggaa
      781 gcttggtatc gcaagacttt caaactagat gaaaaagacc tcaagaaaaa tgttcgcctt
      841 acttttgatg gcgtctacat ggattctcaa gtttatgtca atggtcagtt agtggggcat
      901 tatccaaatg gttataacca gttctcatac gatatcacca aataccttca taaagatggt
      961 cgtgagaatg tgattgctgt ccatgcagtc aacaaacagc caagtagccg ttggtattca
     1021 ggaagtggta tctatcgtga tgtgacttta caagtgacag ataaggtgca tgttgagaaa
     1081 aatgggacaa ctattttaac accaaaactt gaagaacaac aacatggcaa ggttgaaact
     1141 catgtgacca gcaaaatcgt caatacggac gacaaagacc atgaacttgt agccgaatat
     1201 caaatcgttg aacgaggtgg tcatgctgta acaggcttag ttcgtacagc gagtcgtacc
     1261 ttaaaagcac atgaatcaac aagcctagat gcgattttag aagttgaaag accaaaactc
     1321 tggaccgttt taaatgacaa acctgccttg tacgaattga ttacgcgtgt ttaccgtgac
     1381 ggtcaattgg ttgatgctaa gaaggatttg tttggttacc gttactatca ctggactcca
     1441 aatgaaggtt tctctttgaa tggtgaacgt attaaattcc atggagtatc cttgcaccac
     1501 gaccatgggg cgcttggagc agaagaaaac tataaagcag aatatcgccg tctcaaacaa
     1561 atgaaggaga tgggagttaa ctccatccgt acaacccaca accctgctag tgagcaaacc
     1621 ttgcaaatcg cagcagaact aggtttactc gttcaggaag aggcctttga tacttggtat
     1681 ggtggcaaga aaccttatga ctatggacgt ttctttgaaa aagatgccac tcacccagaa
     1741 gctcgaaaag gtgaaaaatg gtctgatttt gacctacgta ccatggtcga aagaggcaaa
     1801 aataaccctg ctatcttcat gtggtcaatt ggtaatgaaa taggtgaagc taatggtgat
     1861 gcccactctt tagcaactgt taaacgtttg gtcaaggtta tcaaggatgt tgataagact
     1921 cgctatgtta ccatgggagc agataaattc cgtttcggta atggtagcgg agggcatgag
     1981 aaaattgctg atgaactcga tgctgttgga tttaactatt ctgaagataa ttacaaagcc
     2041 cttagagcta agcatccaaa atggttgatt tatggatcag aaacatcttc agctacccgt
     2101 acacgtggaa gttactatcg ccctgaacgt gaattgaaac atagcaatgg acctgagcgt
     2161 aattatgaac agtctgacta tgggaatgat cgtgttggtt gggggaaaac agcaaccgct
     2221 tcatggactt ttgaccgtga caacgctggc tatgctggac agtttatctg gacaggtacg
     2281 gactatattg gtgaacctac accatggcac aaccaaaatc aaactcctgt taagagctct
     2341 tactttggta tcgtagatac agccggcatt ccaaaacatg acttctacct ctaccaaagc
     2401 caatgggttt ctgttaagaa gaaaccgatg gtacaccttc ttcctcactg gaactgggaa
     2461 aacaaagaat tagcatccaa agtagctgac tcagaaggta agattccagt tcgtgcttat
     2521 tcgaatgctt ctagtgtaga attgttcttg aatggaaaat ctcttggtct taagactttc
     2581 aataaaaaac aaaccagcga tgggcggact taccaagaag gtgcaaatgc taatgaactt
     2641 tatcttgaat ggaaagttgc ctatcaacca ggtaccttgg aagcaattgc tcgtgatgaa
     2701 tctggcaagg aaattgctcg agataagatt acgactgctg gtaagccagc ggcagttcgt
     2761 cttattaagg aagaccatgc gattgcagca gatggaaaag acttgactta catctactat
     2821 gaaattgttg acagccaggg gaatgtggtt ccaactgcta ataatctggt tcgcttccaa
     2881 ttgcatggcc aaggtcaact ggtcggtgta gataacggag aacaagccag ccgtgaacgc
     2941 tataaggcgc aagcagatgg ttcttggatt cgtaaagcat ttaatggtaa aggtgttgcc
     3001 attgtcaaat caactgaaca agcagggaaa ttcacactga cagcccattc agatctcttg
     3061 aaatctagtc aagtcactgt ctttactggt aaaaaagaag gacaagagaa gactgttttg
     3121 gggacagaag tgccaaaagt acagaccatt attggagagg cacctgaaat gcctaccact
     3181 gttccgtttg tatacagtga tggtagccgt gcagaacgtc ctgtaacctg gtcttcagta
     3241 gatgtgagca agcctggtat tgtaacggtg aaaggtatgg ctgacggacg agaagtagaa
     3301 gctcgtgtag aagtgattgc tcttaaatca gagctaccag ttgtgaaacg tattgctcca
     3361 aatactgact tgaattctgt agacaaatct gtttcctatg ttttgactga tggaagtgtt
     3421 gaagagtatg aagtggacaa gtgggagatt gccgaagaag ataaagctaa gttagcaatt
     3481 ccaggttctc gtattcaagc gaccggttat ttagaaggtc aaccaattca tgcaaccctt
     3541 gtggtagaag aaggcaatcc tgcggcacct gcagtaccaa ctgtaacggt tggtggtgaa
     3601 gctgtcacag gtcttactag tcaaaaacca atgcaatacc gcactcttgc ttatggagct
     3661 aagttgccag aagtcacagc aagtgctaaa aatgcagctg ttacagttct tcaagcaagc
     3721 gcagcaaacg gcatgcgtgc gagcatcttt attcagccta aagatggtgg ccctcttcaa
     3781 acctatgcaa ttcaattcct tgaagaagcg ccaaaaattg ctcacttgag cttgcaagtg
     3841 gaaaaagctg acagtctcaa agaagaccaa actgtcaaat tgtcggttcg agctcactat
     3901 caagatggaa cgcaagctgt attaccagct gataaagtaa ccttctctac aagtggtgaa
     3961 ggggaagtcg caattcgtaa aggaatgctt gagttgcata agccaggagc agtcactctg
     4021 aacgctgaat atgagggagc taaaggccaa gttgaactca ctatccaagc caatactgag
     4081 aagaagattg cgcaatccat ccgtcctgta aatgtagtga cagatttgca tcaggaacca
     4141 agtcttccag caacagtaac agttgagtat gacaaaggtt tccctaaaac tcataaagtc
     4201 acttggcaag ctattccgaa agaaaaacta gactcctatc aaacatttga agtactaggt
     4261 aaagttgaag gaattgacct tgaagcgcgt gcaaaagtct ctgtagaagg tatcgtttca
     4321 gttgaagaag tcagtgtgac aactccaatc gcagaagcac cacaattacc agaaagtgtt
     4381 cggacatatg attcaaatgg tcacgtttca tcagctaagg ttgcatggga tgcgattcgt
     4441 ccagagcaat acgctaagga aggtgtcttt acagttaatg gtcgcttaga aggtactcaa
     4501 ttaacaacta aacttcatgt tcgcgtatct gctcaaactg agcaaggtgc aaacatttct
     4561 gaccaatgga ccggttcaga attgccactt gcctttgctt cagattcaaa tccaagcgac
     4621 ccagtttcaa atgttaatga caagctcatt tcctacaata accaaccagc caatcgttgg
     4681 acaaactgga atcgtagtaa tccagaagct tcagtcggtg ttctgtttgg agattcaggt
     4741 atcttgagca aacgctccgt tgataatcta agtgtcggat tccacgaaga ccatggagtt
     4801 ggtgcaccga agtcttatgt gattgagtat tatgttggta agactgtccc aacagctcct
     4861 aaaaacccta gttttgttgg taatgaggac catgtcttta atgattctgc caactggaaa
     4921 ccagttacta atctaaaagc ccctgctcaa ctcaaggctg gagaaatgaa ccactttagc
     4981 tttgataaag ttgaaaccta tgctattcgt attcgcatgg ttaaagcaga taacaagcgt
     5041 ggaacgtcta tcacagaggt acaaatcttt gcgaaacaag ttgcggcagc caaacaagga
     5101 caaacaagaa tccaagttga cggcaaagac ttagcaaact tcaaccctga tttgacagac
     5161 tactaccttg agtctgtaga tggaaaagtt ccggcagtca cagcaaatgt tagcaacaat
     5221 ggtctcgcta ccgtcgttcc aagcgttcgt gaaggtgagc cagttcgtgt catcgcgaaa
     5281 gctgaaaatg gcgacatctt aggagaatac cgtctgcact tcactaagga taagaactta
     5341 ctttctcata aaccagttgc tgcggttaaa caagctcgct tgctacaagt aggtcaagca
     5401 cttgaattgc cgactaaggt tccagtttac ttcacaggta aagacggcta cgaaacaaaa
     5461 gacctgacag ttgaatggga agaagttcca gcggaaaatc tgacaaaagc aggtcaattt
     5521 actgttcgag gccgtgtcct tggtagtaac cttgttgctg aggtcactgt acgagtgaca
     5581 gacaaacttg gtgagactct ttcagataac cctaactatg atgaaaacag taaccaggcc
     5641 tttgcttcag caaccaatga tattgacaaa aactctcatg accgcgttga ctatctcaat
     5701 gacggagatc attcagaaaa tcgtcgttgg acaaactggt caccaacacc atcttctaat
     5761 ccagaagtat cagcgggtgt gatcttccgt gaaaatggta agattgtaga acggactgtt
     5821 gctcaagcca aacttcactt ctttgcagat agtggtacgg atgcaccatc taaactcgtt
     5881 ttagaacgct atgtcggccc aggctttgaa gtacctacct actattcaaa ctaccaagcc
     5941 tacgaatctg gacatccatt taacaatcca gaaaattggg aagctgtgcc ttatcgtgcg
     6001 gataaagaca tcgcagctgg tgatgaaatc aacgtaacat ttaaagctgt caaagccaaa
     6061 gccatgagat ggcgtatgga gcgtaaagct gacaagagcg gtgttgcgat gattgagatg
     6121 accttccttg caccaagtga attgcctcaa gaaagcacgc aatcaaagat tcttgtagat
     6181 ggaaaagaac ttgctgattt cgctgaaaat cgtcaagact atcaaattac ctataaaggt
     6241 caacggccaa aagtctcagt tgaagaaaac aatcaagtag cttcaactgt ggtagatagt
     6301 ggagaagata gccttccagt acttgttcgc ctcgtttcag aaagtggaaa acaagtcaag
     6361 gaataccgta ttcagttgac taaggaaaaa ccagtttctg ctgtacaaga agatcttcca
     6421 aaactcgaat ttgttgaaaa agatttggcc tacaagacag ttgagaaaaa agattcaaca
     6481 ctgtatctag gtgaaactcg tgtagaacaa gaaggaaaag ttggaaaaga acgtatcttt
     6541 acagtgatta atcctgatgg aagtaaggaa gaaaaactcc gtgaagtggt agaagttccg
     6601 acagaccgca tcgtcttggt tggaaccaaa ccagtagctc aagaagctaa aaaaccacaa
     6661 gtgtcagaaa aagcagatac aaaaccaatt gattcaagtg aagctgatca aactaataaa
     6721 gcccagttac caaatacagg tagtgcggca agccaagcag cagtagcagc aggtttagct
     6781 cttctaggtt tgagtgcagg attagtagtt actaaaggta aaaaagaaga ctagaaattt
     6841 tgataccttc tttatcatta aagaccaaag aaaaactctt gtcctaaata gaagataaag
     6901 agtctggaac aaaatagttc tcaaccacaa aaaagctaga tatttccaat tgcggaactc
     6961 tagcttttta attttgagtc gttctcttat tgtatagtag attgaaacta gaatagtaca
     7021 cttctacttc taaaacattg ttagaaatca atttgactgt ccttatcgat ttgtcctggt
     7081 cttatttcat ttcactatgt tttaggaggt tattggccat aagtaccaat cccatgtcaa
     7141 ttctcacttg acgcttccct ctcagattac atctcttgta acccaaacaa gcctttatct
     7201 gcccaaagac aggtttcaca tcaatcttgc gttgagcgaa atctgtctac cttcaggaga
     7261 taaaagcgcc tgacattctt tagctttcaa gttttgatag cgttcgttca tatacagtcc
     7321 cttttgaggg actgattcag gttcatcagc gtagtaaacc ttgatttcct gttgaaagtc
     7381 tgtctgtgtt ttctgatgtt tggtatggtg aaaacgataa taccagccat caggatgtgt
     7441 gtagctatcc tccttgtcat tatagtgcca attcgctaag tttttagctg actgtttatg
     7501 tcctctcttt tgtttcttat caaacatggc atatttaatc agaaggggag gatttcttct
     7561 tgaaaataga cctgtatctg ttcttgaagt ttggcggaga atttctctgt cgttttcttc
     7621 cacacaaaac tatacttgtt ggcattggct tcaatcttag ttccgtcaat aaacaaacaa
     7681 tctaaggtca ctaactcttc catttttcaa tttttcgacc agagaaaatc ccttgtgaat
     7741 aggcaaatag aagagtagat acaagcattt taaggtgata agacgggcga tcaaaggcat
     7801 gatagaaggc gtagaagtga tgttcctcca aggtattcac cactttttca atagtaaaga
     7861 cgagatggtc ttgtggtaag aaggaactga tttctagtgg taaagttgtt tgatttgtgt
     7921 tatagtgaat atgcatggga tagcctttct aaatggttta ttgggcaatt ctattttacc
     7981 aagactatcg taaccatgca aaaaaagcaa cggcaaatcc gttgcttttt ttggagataa
     8041 gagactattg tcccagactc ttttctttgt ataaaattgt atagtgttat tgtctatact
     8101 attttgtaga gaaagcaaaa atccctagaa aatgcttagg gattcgacta tttcattaag
     8161 aacaattcaa caatcatttc tatatacatg ataagggtta ataagaatcc tgcacgccag
     8221 aagaatttga tgaatttagg atagtaaaag ctgagttttt tcaaaaggaa gaaaaagacg
     8281 agaataatgg ctaggattga gagggctagc cccagtctag ggaggaaatt atgggtaaag
     8341 gttttagctg taatcaggta atattcaaat accaagaccg gaaaagccaa atccgcaaag
     8401 tttcgtccta gtttttttaa tctaaaaagt ttggttagga taatgcagac gactaaggtc
     8461 agtatcaata ataaaataga tgctaatttc attaaaatca tacccatatt gtatcataaa
     8521 aaaaagctaa tggaaacgag aaacagagga atttatagga aagtcaggct tttgagattg
     8581 tgggtgattt ttgttataat gaaagttata aaatcttata ataccttgaa tgattattat
     8641 cgaaaactct ttggagaaaa gacttttaaa gtccctattg atgcggaatt tgactgtccc
     8701 aatcgtgatg gaactgtggc tcatggaggc tgtacttttt gtacggtttc aggttctgga
     8761 gatactattg tagccccaga tgcgcctatc cgtgagcaat tttataagga aattgacttt
     8821 atgcaccgta agtggccgga tgttcagaag tatctggttt attttcaaaa ttttaccaac
     8881 acccatgaaa aggtggaagt tattcgagag cgttatgaac aggctatcaa tgagccaggt
     8941 gtggtaggaa tcaatattgg aatgcgccca gactgtttac cagacgaaac catcgaatat
     9001 ttggctgagt tatcggagtg catgcatgtg acggttgaat tgggcttgta gactacttat
     9061 gaagcaactt ctgacctgat taaccgtgcg tattcttatg aattgtaggt ggaaacggtc
     9121 aagcgtttga gaaagtatcc caagattgag attgtttccc atttgattaa tggtttgcct
     9181 ggtgaaaccc atgagatgat ggttgaaaat gtccgccgtt gtgtcacgaa taacgatatt
     9241 caagggatta aactgcattt gctccatctt atgacaaata ctcgtatgca acgagattac
     9301 catgagggac gtttacaatt gatgagtcag gacgaatatg tcagggtcat ctgtgaccaa
     9361 ctggaaatca ttcccaaaca tatcgtcatc catcgaatca caggagatgc acctagggat
     9421 atgctgattg ggcttatgtg gagcctcaat aaatgggaag ctctcaacag cattgagatg
     9481 gagatgcgac gtcgtggaag tgttcaagga tgcaaggctg taaaacagga gtttgaaaat
     9541 gaaaagacca cttgagatgg cacatgattt tttggctgag gtcgtgacaa aagaggatgt
     9601 cgtagtggat gcgactatgg gaaatggtca tgacacgctt tttttagcca agctagccaa
     9661 gcaagtctat gcctttgata ttcagaagca agccttggaa aagacccaag agcgtttgca
     9721 tcaggctggc ttgacaaatg cccagttaat cttgcaaggc catgagacac tggaccagtt
     9781 tgtgacaaaa gctaaggcag ggatttttaa tttgggctat ttgccgtcag ctgataagtc
     9841 tgtcatcacc cgaccgcaga caacgattga ggcattagaa aagctatgtg gcttacttgt
     9901 caagggtgga cgaattgcta ttatgattta ctatggtcat gaaggaggcg acctcgagag
     9961 agatgctgtc ttggattttg taatccagtt gaaccaacaa gagtacacag ctgccattta
    10021 ccgaacttta aaccaagtca acaacccgcc gtttttagtg atgattgaaa aattagagag
    10081 atacagacat ggataaacaa tacctacacg aaaagctgga tgccatgcgc cagaattttg
    10141 ttgaatcaac ccaccacgaa cgatcggtgg gcgtgctaga ccaagcgcat atgagcaaaa
    10201 aaatgcttaa aatcaagaaa aaattagttg ctcttgaaat ggaacggtgc cagagaaaaa
    10261 ttgagcacaa agactgttcc aagattgacc aaaaaatcaa agagcagaag gagatatttg
    10321 aatcctgttg taaaaaagat taaggaggac gtgcgtggaa ttactgattt acctcatcct
    10381 atttttactg gttttgattg tctcaagtac aaccaataag ctcctgccct ttttgcctct
    10441 ccctttggtg caaattcttt tgggaattgt gattggtctc tttttaccca ataccgactt
    10501 tcacctcaat acggagttgt ttttggccct ggttatcgga cccttgcttt tccgagaggc
    10561 tgaagaagca gatgttacgg ctattttaaa acactggcga atcattgttt atctcatatt
    10621 tccagtgatt tttatctcga ccctgagttt gggtggcttg gcccatcttc tttggttcag
    10681 ccttcccttg gcagcttgct tggctgttgg ggcagccctt ggtcctacgg acttggtggc
    10741 ctttgcctct ctttcggagc gttttagctt tcctaagcgc gtgtccaata ttcttaaggg
    10801 cgaaggactc ttgaatgatg cttctggttt ggtggctttt caggtagctt tgacagcttg
    10861 gacaactgga gctttttctc tggggcaagc tagcagttcg ctcatctttt caatcctagg
    10921 cggtttttta attggatttt taacagccat gaccaaccgc ttcctccata ccttcttgct
    10981 aagtgtgcgc gcaacggata ttgccagtga acttttatta gaattaagtt tgcctctagt
    11041 gaccttcttt ctggcagaag aagttcatgt ttcagggatt attgccgtcg tagttgctgg
    11101 aattttaaag gcaagtcgtt tcaagaaaat cacgctcctc gaagcccaag tggatacggt
    11161 gaccgagacg gtctggcata cagtgacctt tatgctcaac ggttctgtct ttgtgatttt
    11221 agggatggag ttggaaatga tagcagaacc tatcttgacc aatccaatct ataatcctct
    11281 acttttattg ctatctctca tcgcccttac ctttgtcctc tttgtcattc gttttattat
    11341 gatctatggc tattatgcct atagaacccg acgcctcaag aaaaagctaa ataagtatat
    11401 gaaggacatg tttctcttga ccttttcagg tgttaaggga acggtgtcga ttgctacgat
    11461 tctcttgata ccaagtaatc tagaacaaga gtatcctctt ttgcttttcc ttgttgcagg
    11521 tgtgacgctt gtcagctttt taacaggtct cttgatcttg cctcatcttt ctgatgaaga
    11581 ggaagaaagc aaggattatc tcatgcatat cgccattttg aatgaagtaa cgctagagtt
    11641 ggaaaaagag ttggaagaca ccagaaataa acttcccctc tatgcggcta ttgacaatta
    11701 tcatggacgt attgaaaatc tcattttaag ccaagaaaac caggatgatc aagaagactg
    11761 ggctgctttg aaactcttga ttcttagtat tgaaagtgat ggtttggaac aggcctatga
    11821 agaggggaac attagcaatc gtgcttaccg agtttaccaa cgttatctga aaaatataga
    11881 acaaggaatc aatcgtaaac ttgcctcaag actgacctat tattttcttg tttccttgag
    11941 gattttacgt tttctccttc atgaagtttt tactcttgga aagaccttcc gtagctggaa
    12001 ggacaaggag caaagccgtc tccgtgctct tgattatgac caaattgcag agctctatct
    12061 tgccaatacg gagatgatta ttgaaagttt ggaaaacctg aagggagtct acagacgctc
    12121 tttgattagt tttatgcagg agtctcgtct tcgagaaaca actattatca gcagtggtgc
    12181 ctttgtcgaa cgggttatca atcgtgtcaa acccaacaat atcaatgaaa tgctgagagg
    12241 ctattatctg gagcgcaagt tgattttcga atacgaagaa aaacgattaa ttacaactaa
    12301 gtatgccaag aaattacgac aaaatgtaaa taacttagag aactattcct tgaaggaagc
    12361 tgccaatacc ctgccgtatg atatggtgga attggtaaga agaaattagt taatactctt
    12421 cgaaaatctc ttcaaaccac gtcagcgtcg ccttaccgta tgtatgtgac tgacttcgtc
    12481 agtcttatct acaacctcaa aacagtgttt tgagcagctt gcggctagct ttctagtttg
    12541 ctctttgatt ttcattgagt ataagattat aaatgaagga gtatgacatg aaaaagtggt
    12601 ggaaagagct gatagacaag cctttattaa aagctttttt gcattattat caagcatcag
    12661 atagtgagtt gaccagtgtc gcagtagcct actattggtt gatttcgatt ttccccctgc
    12721 ttttggtggt ggtcaatatc ctcccctatt ttcagattcc tgtgggagaa tttctgggct
    12781 ttatgaaaga cgtcctgccc ccaagcctct atgaaggtgt ggaaaaaata gccagagaag
    12841 tcttgacgca accttcaaca ggtttattga gtttttctgt tttatcggcg ttatggagtt
    12901 tttcaaaatc tataaatttc ttgcaaaaag cttttaacaa ggcttatggc gtcgaaaaga
    12961 gtcgtggact tatttcccat cagatgctaa gtctcctagt cagttttggc ttgcagttcc
    13021 tctttgcgtt tgccttgttt ttgatcttat ttggtcagat gattttggct ttacttgctc
    13081 attattggac aaaagatggc attatctatc aggctttaca agggttggca ggtcctctga
    13141 tttacgccct cctctttgct atcttggtca tgctttatta ttttcttccc aatctatcta
    13201 acaggaaaat tagctatacc ctaccaggca gtgcctttgt tctcttggtg attttaggtg
    13261 tactaactct gttctctagt tatctcaatt actatgtcca tcatttggtg gatgtccgaa
    13321 ttttaggttc cgttcttctt gttgttatga tgttttggtt tatcttgatt gctaaaattg
    13381 ttatcctagg cgcggtgatc aatgccagta tgcagagttt gaaagatcag gtctttaaaa
    13441 aagactaact atttatccat tacaaaagcg catagtatca aggctttata gaatcttgat
    13501 actatgcgct tttgtgcttt gacagttttt tgtatagttt ttgtccaaga tttctaaatc
    13561 atctgattaa attcctattt tcccctatca ttgtccctgt tttttcgaaa atggaaggag
    13621 tataataaat ctatcaataa aatgatagga ggaactttat gggtcatatt ttcttttttc
    13681 taagtgtctt tttggcaggg attctatcct tcttttctcc ttgtatctta cctttgttac
    13741 cggtctatac aggagtgtta ctagatgata aggatggtgc tcaggcttct agcggcaaat
    13801 tttcaatctc agttactagt ttattacgaa ctctggcctt tatagcagga atttccttta
    13861 tatttatttt gttgggctat ggagctggtt ttttaggcga tttgctttat gcttcttggt
    13921 tccaatatct tactggggca attattatcc ttcttggttt gcaccaaatg gagattctac
    13981 actttaaggg gctttataag gaaaagaggc tacaactgca aggacagggg caaaatggta
    14041 agggctatag tcaggcattt ttattgggct tgacctttag ttttgcttgg acgccttgcg
    14101 tggggccggt tctggggtct gttttggcct tggcggcttc aggtggttca ggagcttggc
    14161 agggagctgg tctcatgttg gtgtatacgc tgggcttggc gctaccattc ttgcttctag
    14221 ctctgacctc tagttatgtt ttgaaacatt tccgaaaact tcatccctat ctcggaatcc
    14281 tcaaaaaagt gggtggtttt ctcattattg tgatgggatt cttggttctg tttggaaatg
    14341 cttcaatttt aagtcaatta tttgaataaa atggaaagga atatcaatat gaaaaaatgg
    14401 caaacatgtg ttcttggagc aggttcgctc ctttgtttga cggcttgttc aggcaagtcc
    14461 gtgactagtg aacaccaaac gaaagatgaa atgaagacgg agcagacagc tagtaaaaca
    14521 agcgcagcta aagggaaaga ggtggctgat tttgaattga tgggagtaga tggcaagacc
    14581 taccgtttat ctgattacaa gggcaagaaa gtctatctca aattctgggc ttcttggtgt
    14641 tccatctgtc tggctagtct tccagatacg gatgagattg ctaaagaagc tggtgatgac
    14701 tatgtggtct tgacagtagt gtcaccagga cataagggag agcaatctga agcggacttt
    14761 aagaattggt ataagggatt ggattataaa aatctcccag tcctagttga cccatcaggc
    14821 aaacttttgg aaacttatgg tgtccgttct tacccaaccc aagcctttat agacaaagaa
    14881 ggcaagctgg tcaaaacaca tccaggattc atggaaaaag atgcaatttt gcaaactttg
    14941 aaggaattag cctaggaggc gtcttatgaa tgataagtta aaaatcttct tgttgctagg
    15001 agtatttttt ctagccataa ccggtttcta tgttctattg atacgaaatg cagggcagac
    15061 agatgcctcg caaattgaaa aggcggcagt tagccaagga ggaaaagcag tgaaaaaaac
    15121 agaaattagt aaagacgcag acttgcacga aatttatcta gctggaggtt gtttctgggg
    15181 agtggaggaa tatttctcac gtgttcccgg ggtgacggat gccgtttcag gctatgcaaa
    15241 tggtagagga gaaacaacca agtacgaatt gattaaccaa acaggtcatg cagaaaccgt
    15301 ccatgtcacc tatgatgcca agcaaatttc tctcaaggaa atcctgcttc actatttccg
    15361 cattatcaat ccaaccagca aaaataaaca aggaaatgat gtggggaccc agtaccgtac
    15421 tggtgtttat tacacagatg acaaggattt ggaagtgatt aaccaagtct ttgatgaggt
    15481 ggctaagaaa tacgatcaac ctctagcagt tgaaaaggaa aacttgaaga attttgtggt
    15541 ggctgaggat taccatcaag actatctcaa gaaaaatcca aatggctact gccatatcaa
    15601 tgttaatcag gcggcctatc ctgtcattga tgccagcaaa tatccaaaac caagtgatga
    15661 ggaattgaaa aagaccctgt cacctgagga gtatgcagtt acccaggaaa atcaaacaga
    15721 acgagctttc tcaaaccgtt actgggataa atttgaatcc ggtatctatg tggatatagc
    15781 aactggggaa cctctctttt catcaaaaga caaatttgag tctggttgtg gctggcctag
    15841 ttttacccaa cccatcagtc cagatgttgt cacctacaag gaagataagt cctacaatat
    15901 gacgcgtatg gaagtgcgga gccgagtagg agattctcac cttgggcatg tctttacgga
    15961 tggtccacag gacaagggcg gcttacgtta ctgtatcaat agcctctcta tccgctttat
    16021 tcccaaagac caaatggaag aaaaaggcta cgcttattta ctagattatg ttgattaata
    16081 ctcttcgaaa atctcttcaa accacgtcag cgtcgcctta ccgtatgtag ggttactgac
    16141 ttcgtcagtt ttatctacaa cctcaaagct atactttgag ctgacttcgt cagttttatt
    16201 tacaacctca aagctatact ttgagaaacc tgtggctatc ttcctagttt actttttgat
    16261 ttttattgag tataagaggt ctttcctaag cagttagagg agaattttgc tatactgata
    16321 ctagtaagtg gtaaaggagc agagcatgac ctacacaatc ttaatcgtag aagatgaata
    16381 tctggtaaga caaggtttga ctaaactggt caatgtagca gcctacgata tggaaatcat
    16441 cggtcaggct gaaaatggaa ggcaggcttg ggaattgatc caaaagcagg tgccagatat
    16501 cattttaacc gatatcaaca tgcctcatct aaatggcatc cagttggcca gtctggtacg
    16561 agaaacctat cctcaggttc atttggtctt tttaacaggt tacgatgatt ttgattatgc
    16621 cttgtctgct gtcaaactag gtgtggacga ctacctgctc aaaccctttt ctcgtcagga
    16681 tattgaggaa atgttgggga aaatcaaaca aaaactagac aaggaagaga aagaagagca
    16741 gttacaagat ttattgacta ataggtttga aggaaacatg gcccagaaaa tccagtctca
    16801 tctggctgat agccaattta gtttaaagtc tttagccagt gacttaggtt ttagtccgac
    16861 ctatctgagt tccttgatta agaaagagtt gggcttgcct tttcaggatt atctggtgag
    16921 agaacgtgtt aaacaagcca agctcttgct tttaactaca gatctgaaga tttatgagat
    16981 cgcagagaag gttggttttg aagatatgaa ctattttacc caacgtttta agcagattgc
    17041 aggtgtgaca cctcgtcagt ttaagaaggg agaagaccga tgaagcgttc ttctctttta
    17101 gttagaatgg ttatttccat ctttctggtc tttctcattc tcctagctct ggttggaact
    17161 ttctactatc aatcaagttc ttcagccatt gaggccacca ttgagggcaa cagccaaacg
    17221 accatcagcc agactagcca ctttattcag tcttatatca aaaaactaga aaccacctcg
    17281 actggtttga cccagcagac ggatgttctg gcctatgctg agaatcccag tcaagacaag
    17341 gtcgagggaa tccgagattt gtttttgacc atcttgaagt cagataagga cttgaaaact
    17401 gttgtgctgg tgaccaaatc tggtcaggtc atttctacag atgacagtgt gcagatgaaa
    17461 acttcctctg atatgatggc tgaggattgg taccaaaagg ctattcatca gggagctatg
    17521 cctgttttga ctccagctcg taaatcagat agtcagtggg tcatttctgt cactcaagaa
    17581 cttgttgatg caaagggagc caatcttggt gtgcttcgtt tggatatttc ttatgaaact
    17641 ctggaagcct atctcaatca actccagttg gggcagcagg gctttgcctt cattatcaat
    17701 gaaaaccatg aatttgtcta ccatcctcaa cacacagttt atagttcgtc tagcaaaatg
    17761 gaggctatga aaccctacat cgagacaggt cagggttata ctcctggtca caaatcctac
    17821 gtcagtcaag agaagattgc aggaactgat tggacggtac ttggcgtgtc atcattggaa
    17881 aagttagacc aggttcggag tcagctcttg tggaccttgc ttggggccag tgtcacatct
    17941 cttcttgtct gtctctgctt agtgtggttc agtcttaaac gctggattgc tcctttgaag
    18001 gatttgagag aaaccatgtt ggaaattgct tctggtgctc aaaatcttcg tgccaaggaa
    18061 gttggtgcct atgaactgag agaagtaact cgccaattta atgccatgtt ggatcagatt
    18121 gatcagttga tggtagctat tcgtagccag gaagaaacga cccgtcagta ccaacttcaa
    18181 gccctttcga gccagattaa tccacatttc ctctataaca ctttggacac catcatctgg
    18241 atggctgaat ttcatgatag tcagcgagtg gtgcaggtga ccaagtcctt ggcaacctat
    18301 ttccgcttgg cgctcaatca aggcaaggac ttgatttgtc tctctgacga aatcaatcat
    18361 gtccgccagt atctctttat ccagaaacaa cgctatggag ataagctgga atacgaaatt
    18421 aatgaaaatg ttgcctttga taatttagtc ttacccaagc tggtcctaca accccttgta
    18481 gaaaatgctc tttaccatgg cattaaggaa aaggaaggtc agggccatat taaactttct
    18541 gtccagaaac aggattcggg attggtcatc cgtattgagg atgatggcgt tggcttccaa
    18601 gatgctggtg atagtagtca aagtcaactc aaacgtgggg gagttggtct tcaaaatgtc
    18661 gatcaacggc tcaaacttca ttttggagcc aattaccaga tgaagattga ttctagaccc
    18721 caaaaaggaa cgaaagttga aatatatata aatagaatag aaactagcta actcccagtc
    18781 aattctggga gttttatgcg taattgggca aactttctag gttgtctatc ttgctaaaaa
    18841 caagaaaaaa cggtatgata gaagagtgac aacagaggta acagagatga acgagacaca
    18901 gattcaaaga gaaacacgtc aggtagtgga agatgtttta gaaaagacca atttgaaaca
    18961 gggggccctt tttgttttag gtctatcttc tagtgaggtg ctaggtggtc agattgggaa
    19021 agaatccagt caagagattg gtgagctgat agtggagact atcttgggta ttctaggtag
    19081 tagaggtatc catttagcag ttcaaggttg tgagcatgtc aatcgggctc tcgttgttga
    19141 acgtcaggtg gcagagcagt ttggtctgga aattgtcagt gtccatccta ctcttcatgc
    19201 aggaggttcg gggcagttgg cagcctttaa gtttatgcag gatccagttg aggttgaatt
    19261 tatcaaggct catgctggat tggatatcgg agacactgca attggcatgc atgtcaagca
    19321 tgttcaggtt ccgattcgcc ctattttgag agagattggt catgcccatg taacggcact
    19381 gactagtcgt ccaaaattaa tcggaggtgc gcgtgcgcac tatccgcaag atgctattag
    19441 gaagttttga gaatgaataa aggagataaa agtgtttaaa aaagaccgtt tttcaattcg
    19501 taagattaag ggagttgtag gctctgtatt tcttggaagc cttttgatgg ctccttctgt
    19561 agtggacgca gccacctatc actatgtaaa taaagagatt atttcacaag aagctaaaga
    19621 tttaattcag acaggaaagc ctgacaggaa tgaagttgta tatggtttgg tgtatcaaaa
    19681 agatcagttg cctcaaacag ggacagaagc atctgttttg acagcttttg gtttgctgac
    19741 tgttgggagc ttgcttttaa tctacaagag aaagaaaatt
//
LOCUS       DBMVGT010000030        19677 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.030, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000030 DBMVGT010000000
VERSION     DBMVGT010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 19677)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19677)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19677
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.030"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(33..2192)
                     /gene="pbp1a"
                     /locus_tag="AC0DU4_001209"
     CDS             complement(33..2192)
                     /gene="pbp1a"
                     /locus_tag="AC0DU4_001209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001040003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein PBP1A"
                     /protein_id="HIN4237172.1"
                     /translation="MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSE
                     SKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGID
                     TIRILGAFLRNLQSNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQK
                     ATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDP
                     YSHPEAAQDRRNLVLSEMKNQGYISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYL
                     KEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIV
                     DVSNGKVIAQLGARHQSSNVSFGINQAVETNRDWGSTMKPITDYAPALEYGIYDSTAT
                     IVHDEPYNYPGTNTPVYNWDRGYFGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLN
                     GLGIDYPSIHYSNAISSNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFS
                     DGSEKEFSNVGTRAMKETTAYMMTDMMKTVLSYGTGRNAYLAWLPQAGKTGTSNYTDE
                     EIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAKVYRSMMTY
                     LSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWNSPAPQQPPSTESSSSSSDSSTSQSS
                     STTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP"
     gene            complement(2189..2785)
                     /gene="recU"
                     /locus_tag="AC0DU4_001210"
     CDS             complement(2189..2785)
                     /gene="recU"
                     /locus_tag="AC0DU4_001210"
                     /EC_number="3.1.21.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RecU"
                     /protein_id="HIN4237173.1"
                     /translation="MVNYPHKVSSQKRQTSLSQPKNFANRGMSFEKMINATNDYYLSQ
                     GLAVIHKKPTPIQIVQVDYPQRSRAKIVEAYFRQASTTDYSGVYNGYYIDFEVKETKQ
                     KRAIPMKNFHPHQIQHMEQVLAQQGICFVLLHFSSQQETYLLPAFDLIRFYHQDKGQK
                     SMPLEYIREYGYEIKAGAFPQIPYLNVIKEHLLGGKTR"
     gene            2851..3378
                     /locus_tag="AC0DU4_001211"
     CDS             2851..3378
                     /locus_tag="AC0DU4_001211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1273 domain-containing protein"
                     /protein_id="HIN4237174.1"
                     /translation="MATALVLGYSAFDLGLFSDKDPRLKLIKKAIRKDLEAMAADGVS
                     WLVFTGTLGFEYWVLEVAQEMKTEYGFQLATIFAFETHGENWNEGNQMKLSRFKQVDF
                     VKYAYPRYEHKGQLRDYQQFLLENTTSSYLFYDEENETKLAYFYQKMKNQEDYFIKRL
                     TFDQLNELAENFSEN"
     gene            3448..3777
                     /gene="gpsB"
                     /locus_tag="AC0DU4_001212"
     CDS             3448..3777
                     /gene="gpsB"
                     /locus_tag="AC0DU4_001212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division regulator GpsB"
                     /protein_id="HIN4237175.1"
                     /translation="MASIIFSAKDIFEQEFGREVRGYNKVEVDEFLDDVIKDYETYAA
                     LVKSLRQEIADLKEELTRKPKPSPVQAEPLEAAITSSMTNFDILKRLNRLEKEVFGKQ
                     ILDNSDF"
     gene            3798..4178
                     /gene="rnpB"
                     /locus_tag="AC0DU4_001213"
     ncRNA           3798..4178
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="AC0DU4_001213"
                     /product="RNase P RNA component class B"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00011"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00011"
     gene            4263..5420
                     /locus_tag="AC0DU4_001214"
     CDS             4263..5420
                     /locus_tag="AC0DU4_001214"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0001510 - RNA methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="THUMP domain-containing class I SAM-dependent
                     RNA methyltransferase"
                     /protein_id="HIN4237176.1"
                     /translation="MKKEFNLIATVAAGLEAVVGREVRELGYDCQIENGRVRFQGDVR
                     AIIETNLWLRAADRIKIIVGTFPAKTFEELFQGVFALDWENYLPLGARFPISKAKCVK
                     SKLHNEPSVQAISKKAVVKKLQKHYARPEGVPLMENGPEFKIEVSILKDVATVMIDTT
                     GSSLFKRGYRTEKGGAPIKENMAAAILQLSNWYPDKPLIDPTCGSGTFCIEAVMIARK
                     MASGLRRSFAFEEWNWISDRLIQEVRTEAAKKVDRELELDIMGCDIDARMVEIAKANA
                     QAAGVAGDITFKQMRVQDLCSDKINGVIISNPPYGERLSDDAGVTKLYAEMGQVFAPL
                     KTWSKFILTSDEAFESKYGSQADKKRKLYNGTLKVDLYQYFGQRVKRQEVK"
     gene            5433..6827
                     /gene="mapZ"
                     /locus_tag="AC0DU4_001215"
     CDS             5433..6827
                     /gene="mapZ"
                     /locus_tag="AC0DU4_001215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division site-positioning protein MapZ"
                     /protein_id="HIN4237177.1"
                     /translation="MSKKRRNRQKKEGQEPQFDFDEAKELTVGQAIRKNEEVEAGVLP
                     EDSILDKYVKQHRDEIEADKFATRQYKKEEFVETQSLDDLIQEMREAVEKSEASSEEV
                     PSSEDILLPLPLDDEEQGLDPLLLDDENPTEMTEEVEEEQNLSRLDQEDSEKKSKKGF
                     ILTVLALVSVIICVSAYYVYRQVARSTKEIETSQSTTANQSDVDDFNTLYDAFYTDSN
                     KTALKNSQFDKLNQLKTLLDKLEGSREHTLAKSKYDSLATQIKAIQDVNAQFEKPAIV
                     DGVLDTNAKAKSDAKFTDIKTGNTELDKVLDKAISLGKSQQTSTSSSSSSQTSSSSSS
                     QASSNTTSEPKPSSSNETRSSRSEVNMGLSSAGVAVQRSASRVAYNQSAIDDSNNSAW
                     DFADGVLEQILATSRSRGYITGDQYILERVNIVNGNGYYNLYKPDGTYLFTLNCKTGY
                     FVGNGAGHADDLDY"
     gene            6903..8327
                     /gene="gndA"
                     /locus_tag="AC0DU4_001216"
     CDS             6903..8327
                     /gene="gndA"
                     /locus_tag="AC0DU4_001216"
                     /EC_number="1.1.1.44"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_process: GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="HIN4237178.1"
                     /translation="MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIA
                     CHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGN
                     TFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEIS
                     AKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAE
                     IFTEWNKGELDSYLIEITADILSHKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDL
                     GVPLSLITESVFARYISTYKEERVYASKVLPKPAAFNFEGDKAELIEKIRQALYFSKI
                     ISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLL
                     LDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRD
                     YFGAHTYQRKDKEGTFHYSWYDEK"
     gene            8339..9028
                     /locus_tag="AC0DU4_001217"
     CDS             8339..9028
                     /locus_tag="AC0DU4_001217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000518023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HIN4237179.1"
                     /translation="MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQ
                     TDYDLMLLNVNLGDMMAQDFAEKLSRTKPASVIMILDHWEDLQEELEVVQRFAVAYIY
                     KPVLIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
                     REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIK
                     TVRGVGYTMQE"
     gene            9126..10142
                     /gene="cbpC"
                     /locus_tag="AC0DU4_001218"
     CDS             9126..10142
                     /gene="cbpC"
                     /locus_tag="AC0DU4_001218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpC"
                     /protein_id="HIN4237180.1"
                     /translation="MKLLKKMMQVLLAVFFFGLLATNTVFANTTGGQFVDKDNRKYYV
                     KDDHKAIYWHKIDGKTYYFGDIGEMVVGWQYLEIPGTGYRDNLFDNQPVNEIGLQEKW
                     YYFGQDGALLEQTDKQVLEPKTSENTGKVYGEQYPLSAEKRTYYFDNNYAVKTGWIYE
                     DGNWYYLNKLGNFGDDSYNPLPIGEVAKGWTQDFHVTIDIDRSKPAPWYYLDASGKML
                     TDWQKVNGKWYYFGSSGSMATGWKYVRGKWYYLDNKNGDMKTGWQYFGNKWYYLRSSG
                     AMVTGWYQDGLTWYYLNAGNGDMTTGWFQVNGRWYYAYSSGALAVNTTVDGYSVNYNG
                     EWVQ"
     gene            10264..11142
                     /gene="mvk"
                     /locus_tag="AC0DU4_001219"
     CDS             10264..11142
                     /gene="mvk"
                     /locus_tag="AC0DU4_001219"
                     /EC_number="2.7.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004496 - mevalonate kinase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0016126 - sterol biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="mevalonate kinase"
                     /protein_id="HIN4237181.1"
                     /translation="MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVP
                     AESPWRLYEEDTLSMAVYASLEYLNITEACIRCEIDSAIPEKRGMGSSAAISIAAIRA
                     VFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDL
                     SAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQI
                     LSQAHLHLKEIGVSSPEADFWVETTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELA
                     ERLEEKGAVQTWIESL"
     gene            11124..12077
                     /gene="mvaD"
                     /locus_tag="AC0DU4_001220"
     CDS             11124..12077
                     /gene="mvaD"
                     /locus_tag="AC0DU4_001220"
                     /EC_number="4.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000373478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0004163 - diphosphomevalonate
                     decarboxylase activity [Evidence IEA];
                     GO_process: GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="HIN4237182.1"
                     /translation="MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYT
                     ETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAA
                     GLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEI
                     YPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLK
                     ENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMD
                     AGPNVKVFCQEKDLEHLSEIFGHRYRLIVSKTKDLSQDDCC"
     gene            12064..13071
                     /locus_tag="AC0DU4_001221"
     CDS             12064..13071
                     /locus_tag="AC0DU4_001221"
                     /EC_number="2.7.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000562378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004631 - phosphomevalonate kinase
                     activity [Evidence IEA];
                     GO_process: GO:0016126 - sterol biosynthetic process
                     [Evidence IEA];
                     GO_process: GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomevalonate kinase"
                     /protein_id="HIN4237183.1"
                     /translation="MIAVKTCGKLYWAGEYAILEPGQLALIKDIPIYMRAEIAFSDSY
                     RIYSDMFDFAVDLRPNPDYSLIQETIALMGDFLAVRGQNLRPFSLKICGKMEREGKKF
                     GLGSSGSVVVLVVKALLALYNLSVDQELLFKLTSAVLLKRGDNGSMGDLACIVAEDLV
                     LYQSFDRQKAAAWLEEENLATVLERDWGFFISQVKPTLECDFLVGWTKEVAVSSHMVQ
                     QIKQNINQNFLSSSKETVVSLVEALEQGKAEKVIEQVEVASKLLEGLSTDIYTPLLRQ
                     LKEASQDLQAVAKSSGAGGGDCGIALSFDAQSTKTLKNRWADLGIELLYQERIGHDDK
                     S"
     gene            13055..14065
                     /gene="fni"
                     /locus_tag="AC0DU4_001222"
     CDS             13055..14065
                     /gene="fni"
                     /locus_tag="AC0DU4_001222"
                     /EC_number="5.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000210649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA];
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_process: GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="HIN4237184.1"
                     /translation="MTTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLS
                     TEFAGRKWDFPFYINAMTGGSNKGREINQKLAQVAESCGILFVTGSYSAALKNPTDNS
                     FSVKSSHPNLLLGTNIGLDKPVELGLQTVEEMNPVLLQVHVNVMQELLMPEGERKFRS
                     WQSHLADYSKQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRR
                     SGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKSVGLSRT
                     VLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEANDQMK
                     KA"
     gene            14142..14840
                     /gene="liaF"
                     /locus_tag="AC0DU4_001223"
     CDS             14142..14840
                     /gene="liaF"
                     /locus_tag="AC0DU4_001223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-active antibiotics response protein
                     LiaF"
                     /protein_id="HIN4237185.1"
                     /translation="MRKFKIFLFIEACLLTGALILMVSEHFSRFLLILFLFLLLIRYY
                     TGKEGNNLLLVAATILFFFIVMLNPFVILAIFVAVIYSLFLLYPMMNQEKEQTNLVFE
                     EVVTVKKEKNRWFGNLHHFSSYQTCQFDDINLFRFMGKDTIHLERVILTNHDNVIILR
                     KMVGTTKIIVPVDVEVSLSVNCLYGDLTFFNQPKRALRNEHYHQETKDYLKSNKSVKI
                     FLTTMIGDVEVVRG"
     gene            14837..15832
                     /locus_tag="AC0DU4_001224"
     CDS             14837..15832
                     /locus_tag="AC0DU4_001224"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HIN4237186.1"
                     /translation="MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEK
                     FFFLLLVFSMSMTCLLALFWRGIEELSLRKMQANLKRLLAGQEVVQVVDPDLDASFKS
                     LSGKLNLLTEALQKAENHSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ
                     QALKLDREKMQTQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELED
                     KSDLRVSLKQNMTKLPKKIEEHIFRILQELISNTLRHAQASCLDVYLYQTDVELQLKV
                     VDNGIGFQLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLAVDIRIPLLDKE"
     gene            15846..16478
                     /locus_tag="AC0DU4_001225"
     CDS             15846..16478
                     /locus_tag="AC0DU4_001225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HIN4237187.1"
                     /translation="MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALE
                     LRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIVTSYLDNEKIMPVLDAGAKGYML
                     KTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
                     ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF"
     gene            16554..17247
                     /locus_tag="AC0DU4_001226"
                     /pseudo
     CDS             16554..17247
                     /locus_tag="AC0DU4_001226"
                     /inference="COORDINATES: protein motif:HMM:NF020296.6"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
     gene            17397..17636
                     /locus_tag="AC0DU4_001227"
     CDS             17397..17636
                     /locus_tag="AC0DU4_001227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237188.1"
                     /translation="MKKTVYKKLGISIIASTLLASQLSTVSALSVISSTGEEYEVSET
                     LEKGPESNDSSLSEISPTYGSYYQKQSEVLSVMMI"
     gene            17717..18538
                     /gene="cbpG"
                     /locus_tag="AC0DU4_001228"
     CDS             17717..18538
                     /gene="cbpG"
                     /locus_tag="AC0DU4_001228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001100143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpG"
                     /protein_id="HIN4237189.1"
                     /translation="MNVEGRGSANFIKDNVLITAAHNYYRHDYGKEADDIYVLPAVSP
                     SQELFGKIKVKEVRYLKEFRNLNSKDAREYDLALLILEEPIGAKLGTLGLPTSQKNLT
                     GITVTITGYPSYNFKIHQMYTDKKQVLSDDGMFLDYQVDTLEGSSGSTVYDASHRVVG
                     VHTLGDGANQINSAVKLNERNLPFIYSVLKGYSLEGWKKINGSWYHYRQHDKQTGWQE
                     INDTWYYLDSSGKMLTDWQKVNGKWYYLNSNGAMVTGSQTIDGKVYNFASSGEWI"
     gene            18557..19579
                     /gene="cbpF"
                     /locus_tag="AC0DU4_001229"
     CDS             18557..19579
                     /gene="cbpF"
                     /locus_tag="AC0DU4_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpF"
                     /protein_id="HIN4237190.1"
                     /translation="MKLLKKMMQIALATFFFGLLATNTVFADDSEGWQFVQENGRTYY
                     KKGDLKETYWRVIDGKYYYFDPLSGEMVVGWQYIPAPHKGVTIGPSPRIEIALRPDWF
                     YFGQDGVLQEFVGKQVLEAKTATNTNKHHGEEYDSQAEKRVYYFEDQRSYHTLKTGWI
                     YEEGHWYYLQKDGGFDSRINRLTVGELARGWVKDYPLTYDEEKLKAAPWYYLNPATGI
                     MQTGWQYLGNRWYYLHSSGAMATGWYKEGSTWYYLDAENGDMRTGWQNLGNKWYYLRS
                     SGAMATGWYQESSTWYYLNASNGDMKTGWFQVNGNWYYAYDSGALAINTTVGGYYLNY
                     NGEWVK"
BASE COUNT         5853 a         3457 c         4623 g         5744 t
ORIGIN      
        1 aaaatcaccc agaaaaatct gggtgataaa tgttatggtt gtgctggttg aggattctga
       61 ttttgttgat caggggttgt atttgattgt tgcgtattat tgttaggatt ggtagtcgta
      121 ctattatttg tgcttggagt ggttgagcta gactgtgaag ttgaactatc tgatgatgag
      181 cttgaacttt cagttgatgg gggttgttgt ggagcaggtg agttccacgt agaacgagca
      241 ccatttttaa atacgaattc tccatttctg tagagcccct ctggtatatt ccaatcctct
      301 ggattgcttc cttcagacag ataggtcatc atagagcggt aaactttggc agcgaccgta
      361 agaccattgc ctacaagtgg tgtcagacgg ttagaatagc ctgtccatac agccattgaa
      421 tatttacgcg tatagccagc aaatagttca tcaggtgcta caaattgaga ggtcttgatg
      481 tggttttcaa tttcctcgtc tgtatagtta gaggttcctg ttttaccagc ctgagggagc
      541 caagcaagat aggcatttcg tccagttcca taactcaaga ctgttttcat catgtcggtc
      601 atcatatagg ctgtcgtttc cttcatggca cgagttccga cattagagaa ctctttttca
      661 ctcccatcac taaagacgac tttatggata tacattggtt tatagtaagt tccaccattt
      721 gcaaaggcag cgtaagcagc agccatcttt tcactacttg ctccatattt tttgtctgat
      781 tcggttgtgt tacttgaaat ggcatttgag tagtgaatac ttgggtagtc gattccgaga
      841 ccatttagga aagtcttggc gcggttgagt ccgaccttgt ttagagtttc cacggctggg
      901 acgtttcgcg attgttgcag ggcgtattgc aaggtgatgt tgccaaagta gcccctatcc
      961 cagttataaa caggggtatt tgtcccaggg tagttatagg gctcatcgtg aacgatagta
     1021 gcagttgaat cgtagatacc gtactccaag gcaggagcat agtctgtgat cggtttcata
     1081 gttgatcccc agtcgcggtt tgtttctact gcttggttaa ttccgaagga aacattactt
     1141 gactgatggc gtgctcctag ctgggcaatg actttaccgt tagaaacatc aacaatggta
     1201 gaagcgactt gcaattcatc gtctggatag gcaacgtatt cgtctgtatt gtaaatatcc
     1261 cacagatgtt tttgagcttc ttggtctaca tttgtgtaga catccatccc agttgtgagc
     1321 aggttatagc ctgtttcttc ttcaacttga ttgatgactt ccttgaggta attatccatg
     1381 taagcagggt aattacttgc tgatttgaga ctttgtagtc catcagtaat tggtgtattg
     1441 actgctttct catactgttc agcagagatg tagccttgat ttttcatttc agataagacc
     1501 aagtttcggc ggtcttgggc tgcttctgga tgtgaatagg ggtcatattg gtttggtgcc
     1561 tgaggcattc cagccagcaa ggctaactga ggtaaactta aattattgag gtctttacca
     1621 tagtagtttt gagctgctgt ctgcattcca tagttcccat tagacatgta gaccttattt
     1681 atatagtagg tcaagatttc ttgcttggtt gctttttgtt ctaactgaat cgctaaccaa
     1741 gcttcctgag ccttacgaga aatagtctgg tcggaagtcg aagttgaaaa gtaagtcaac
     1801 ttaatcaact gttgagtgag agttgatcca ccttggaggg aattgctttg cagattgcgc
     1861 aagaaagctc ccaggatacg gatggtatca atccccctgt ggtcgaagaa gcgatggtct
     1921 tcgatagaaa cgattgcttt aaccaaatct gtgggaatat cattagcttg ggcattgacg
     1981 cggcgttcag aacccaagtc agcaatgagt tgatttttat tgtcgtagat tttactagaa
     2041 gttgttgcaa ctagtttact ctcggatagg ctaggagcct tgctaacgta gtagaaaaaa
     2101 actcctccgc ctaagacaat ggctgcgata accaagctta agaagctaat gctcagatac
     2161 ttgattaggc gcagaatcgt tggtttgttc atcttgtttt accacctaat aaatgttctt
     2221 tgataacatt gagataagga atttgaggga aggcaccagc cttgatttca tatccatatt
     2281 ctcgaatata ttcaagtggc attgattttt gtcccttatc ttgatgatag aagcgaatca
     2341 aatcgaatgc cggcaataag taggtttctt gctgagaaga aaagtgaaga aggacaaagc
     2401 agattccttg ttgagcaagg acttgttcca tatgctgaat ctgatgtgga tgaaaatttt
     2461 tcatcggaat cgcacgtttt tgttttgttt ccttgacttc aaagtcgatg taatatccat
     2521 tataaacgcc agaatagtcc gtcgttgaag cttgtcgaaa ataggcttca acaatcttgg
     2581 cacgacttcg ttgtggatag tccacttgta cgatttgaat aggagttggt ttcttatgta
     2641 taacagccaa gccctgagac aaatagtagt cgttggtagc attgatcatc ttttcaaaag
     2701 acattcctcg atttgcgaaa tttttgggtt gagaaagaga tgtttgtctt ttttgtgatg
     2761 aaactttatg tggatagttg accataattc tccttattgg tacaataaca tcactttatt
     2821 ataccataat ttgcacagaa agggttaaaa atggctacag ctttggtttt aggctattct
     2881 gcttttgatt tgggtttatt ttctgataag gatcctcgtc ttaaattgat taaaaaagcg
     2941 atacgtaaag atttagaggc tatggcagca gatggggtgt cttggcttgt gtttacaggg
     3001 actttgggct ttgaatattg ggttttagag gttgctcagg agatgaaaac cgaatacggt
     3061 ttccagttgg ccaccatttt tgcttttgaa acccatgggg aaaattggaa tgaaggcaat
     3121 cagatgaaac tgagtcgctt taagcaggta gactttgtca aatatgccta tcctcgctat
     3181 gaacacaagg ggcagttaag agattaccag cagtttttgc tggaaaacac gactagttcc
     3241 tatctttttt atgatgaaga aaatgaaaca aaactagctt atttttacca aaagatgaaa
     3301 aatcaagagg actattttat aaagagatta acatttgatc aattaaatga acttgctgaa
     3361 aatttttccg aaaattgaag ctttgacctt gatttttgtt tgcctttttt tatataataa
     3421 tactagcaag cgagaatgga gagagacatg gcaagtatta ttttttcagc gaaagatatt
     3481 tttgaacaag agtttggacg tgaagtccgt ggctataata aagtagaagt tgacgagttt
     3541 ttagacgatg tcatcaagga ctatgaaacc tatgctgcct tggtcaagtc acttcgtcag
     3601 gaaattgcgg atttgaagga agaattaact cgtaaaccga aaccttcacc agttcaagca
     3661 gaaccccttg aagcggcaat tacaagttct atgacgaatt ttgatatttt gaaacgcctg
     3721 aatagattgg aaaaagaagt ttttggtaaa caaattttag ataactcaga tttttaagta
     3781 gttatttgag atgtgcaatt tttggataat cgcgtgagga gaattgcttc tcatgaggaa
     3841 agtccatgct agcacaggct gtgatgcctg tagtgtttgt gctaggcgaa accataagcc
     3901 tagggacgag aaatcgttac ggcagttgaa atggctaagt ccttggatag gccagagtag
     3961 gcttgaaagt gccacagtga cgaagtcttt ctggaaacag agagagtgga acgcggtaaa
     4021 cccctcaagc tagcaaccca aattttggtc ggggcatgga gtacgcggaa acgaacgtag
     4081 tattctgact gctatcagct agagctgtta gtggtagaca gatgattatc gaaggaagtg
     4141 gtcctagtca cttctggaac aaaacatggc ttatagaaaa ttgcatatag gttggggctg
     4201 agaaattttc tcaacctcat tttttaaagt ggacatatag aaaggtcttg caagactgta
     4261 acatgaaaaa agaatttaat ttaattgcaa ctgtggcagc agggcttgag gctgtcgttg
     4321 gtcgtgaagt gcgagagttg ggctacgatt gtcagattga aaatggacgt gttcgttttc
     4381 aaggagacgt gagagctatt atcgaaacca acctttggct gcgggcagca gatcgtatca
     4441 aaattatcgt aggaacgttc cctgctaaga cttttgaaga gctatttcag ggagttttcg
     4501 ctttagattg ggaaaattat ttaccacttg gagctcggtt cccgatttca aaagctaaat
     4561 gtgttaagtc caaacttcac aatgagccca gtgttcaggc tatttctaag aaagctgttg
     4621 tcaagaaatt gcagaaacac tatgctcgcc cagaaggggt tcctctgatg gagaatggcc
     4681 cagagtttaa gattgaggtc tctattctca aagatgtggc aactgtcatg attgatacga
     4741 ccgggtctag cctctttaaa cgtggttatc gtaccgaaaa aggtggcgct cctatcaagg
     4801 aaaatatggc agcagccatt ttacaacttt ctaactggta tccagacaag cctttgattg
     4861 atccgacctg tggttcgggg actttctgta ttgaggcagt tatgattgct agaaagatgg
     4921 cgtcaggtct tcgtcgctct tttgcatttg aggaatggaa ctggatcagc gatcgcttga
     4981 ttcaagaagt gcgcacagaa gcggctaaaa aagtagaccg tgagcttgag ctggatatca
     5041 tgggctgtga tattgatgct cgcatggtgg aaattgctaa ggccaatgct caggcagctg
     5101 gtgttgcagg agacattact tttaagcaga tgcgcgtgca ggatttatgt tccgataaaa
     5161 tcaatggagt aatcatttcc aatccgcctt atggtgaacg tttgtcagat gatgcagggg
     5221 tgaccaagct ctatgctgag atggggcaag tatttgcacc gctgaaaact tggagcaaat
     5281 ttatcctgac tagtgatgaa gcttttgaaa gcaagtatgg tagccaagca gataagaagc
     5341 gtaagttata caacggaacc ttgaaagtgg atctgtatca atattttggt cagcgtgtca
     5401 aacggcaaga ggtaaaatag aaagggatac tcatgagtaa aaaaagacga aatcgtcaaa
     5461 aaaaagaagg tcaagaaccg caatttgatt ttgatgaagc aaaagagcta acagttggtc
     5521 aagctattcg taaaaatgaa gaagtggaag caggagtctt gcctgaggat tccattttgg
     5581 acaagtatgt taagcaacac agagatgaaa ttgaggcgga taagtttgcg actcgtcaat
     5641 acaaaaaaga ggagttcgtt gaaactcaga gtctggatga tttaattcaa gagatgcgtg
     5701 aggctgtaga gaagtcagaa gcttcttcgg aggaagttcc atcttctgaa gacatcttac
     5761 tacccttgcc tctggacgat gaggagcaag gcttggatcc tctattgcta gatgatgaaa
     5821 atccaacaga aatgactgaa gaagtggaag aggagcaaaa cctttctcgt ctggatcaag
     5881 aggactcaga aaagaaaagt aaaaaaggct ttattttgac cgttttggcg cttgtatcag
     5941 taattatttg tgtcagtgct tattatgtct accgtcaagt ggctcgttcg accaaggaaa
     6001 ttgaaacttc tcaatcaact acagccaatc aatcggatgt ggatgatttt aatacacttt
     6061 atgacgcctt ttacacagat agcaataaaa cggctttgaa aaatagccag tttgataaac
     6121 tgaatcaact caagacttta cttgataagc tggaaggtag tcgtgaacat acgcttgcca
     6181 aatctaaata tgatagtcta gcaacgcaaa tcaaggctat tcaagatgtc aatgctcaat
     6241 ttgagaaacc agctattgtg gatggtgtgt tggataccaa tgccaaagcc aaatcggatg
     6301 ctaaatttac ggatattaaa actggaaata cggagcttga taaagtgcta gataaggcta
     6361 tcagtcttgg taagagccag caaacaagta cttctagctc aagttcaagt caaactagca
     6421 gctcaagttc aagtcaagca agttcaaata cgactagtga gccaaaacca agtagttcaa
     6481 atgagactag aagtagtcgc agtgaagtca atatgggtct ctcgagtgca ggggttgctg
     6541 ttcaaagaag tgccagtcgt gttgcctata atcagtctgc tattgatgat agtaataact
     6601 ctgcctggga ttttgcggat ggtgtcttgg aacaaattct agcgacttca cgttcacgtg
     6661 gctatatcac tggagaccaa tatatccttg aacgtgtcaa tatcgttaac ggcaatggtt
     6721 attacaacct ctataagcca gatggaacct atctctttac ccttaactgt aagacaggct
     6781 actttgtcgg aaatggcgct ggtcatgcgg atgacttgga ctactaagca gtcgttacaa
     6841 aattctttct tttcaaaagt aaaaatgata aaataaaaca aatgaaacaa gaggagtgtc
     6901 aaatgacaaa agctaacttt ggtgtcgtag gtatggccgt aatgggtcgt aaccttgccc
     6961 ttaatattga atcacgtggt tacacagttg ctatctacaa ccgtagtaaa gaaaaaacgg
     7021 aagatgtgat tgcttgccat cctgaaaaga attttgtacc aagctatgac gttgaaagtt
     7081 ttgtaaactc aatcgaaaaa cctcgtcgta tcatgctgat ggttcaagct ggacctggta
     7141 cagatgctac tatccaagcc cttcttccac accttgacaa gggtgatatc ttgattgacg
     7201 gaggaaacac tttctacaaa gataccatcc gtcgtaatga agaattggca aactcaggta
     7261 tcaactttat cggtactgga gtttctggtg gtgaaaaagg tgcccttgaa ggtccttcta
     7321 tcatgcctgg tggacaaaaa gaggcctacg aattggttgc ggatgttctt gaagaaatct
     7381 cagctaaagc accagaagat ggcaaaccat gtgtgactta catcggccct gatggagctg
     7441 gtcactatgt gaaaatggtt cacaatggta ttgagtacgg tgatatgcaa ttgatcgcag
     7501 aaagctatga cttgatgcaa cacttgctag gcctttctgc agaggatatg gctgaaatct
     7561 ttactgagtg gaacaagggt gaattagaca gctatttgat cgaaatcaca gctgatatct
     7621 tgagccataa agacgatgaa ggccaagatg gaccaatcgt agactacatc cttgatgctg
     7681 caggtaacaa gggaactggt aaatggacta gccaatcatc tcttgacctt ggtgtaccat
     7741 tgtcactgat tactgagtca gtgtttgcac gctacatttc aacttacaaa gaagaacgtg
     7801 tatatgctag caaggtgctt ccaaaaccag ctgccttcaa ctttgaagga gacaaggctg
     7861 aattgattga aaagatccgt caagcccttt acttctcaaa aatcatttca tacgcacaag
     7921 gatttgctca attgcgtgta gcctctaaag aaaacaactg gaacttgcca tttgcagata
     7981 tcgcatctat ctggcgtgat ggctgtatca tccgttctcg tttcttgcaa aagattacag
     8041 atgcttacaa ccgcgatgca gatcttgcca accttctttt ggacgagtac ttcttggatg
     8101 ttactgctaa gtatcaacaa gcagtgcgtg atatcgtagc tcttgcggtt caagctggtg
     8161 tgccagtgcc aactttctca gcagctatta cttactttga tagctaccgt tcagctgacc
     8221 ttccagctaa cttgatccaa gcacaacgtg actactttgg tgctcacact taccaacgta
     8281 aagacaaaga aggaaccttc cactactctt ggtatgacga aaaataagta ggtcagccat
     8341 ggggaaacgg attttattac ttgagaaaga acgaaatcta gctcattttt taagtttgga
     8401 actccagaaa gagcagtatc gggttgatct ggtagaggag gggcaaaaag ccctctccat
     8461 ggctcttcag acagactatg atttgatgtt attgaacgtt aatctgggag atatgatggc
     8521 tcaggatttt gcagaaaaat tgagtcgaac taaacctgcc tcagtcatca tgattttaga
     8581 tcattgggaa gacttgcaag aagagctgga agttgttcag cgttttgcag ttgcatacat
     8641 ttataagcca gtccttatcg aaaatctggt agcgcgtatt tcggcgatct tccgaggtcg
     8701 ggacttcatt gatcaacact gcagtctgat gaaagttcca aggacttacc gcaatcttag
     8761 gatagatgtt gaacatcaca cggtttatcg tggtgaagag atgattgctc tgacccgccg
     8821 tgagtatgac cttttggcga cacttatggg aagcaagaaa gtattgactc gtgagcaatt
     8881 gttggaaagt gtttggaagt atgaaagtgc gaccgagaca aatatcgtag atgtctatat
     8941 ccgctatcta cggagcaagc ttgatgttaa aggccaaaaa agctacatta aaaccgtgcg
     9001 tggtgttgga tataccatgc aagaatagat aagcagttgc agttgtgtaa ctgctttttt
     9061 gaggagtttt tatatattga catgcagtcg ggtctttgct acaatcgttt taggaggata
     9121 tatagatgaa acttttgaaa aaaatgatgc aagttctact agcagtcttt ttctttggtt
     9181 tgctagctac aaatacggta tttgcgaata ccacaggtgg ccaatttgtt gataaggata
     9241 atagaaaata ttatgtaaaa gatgatcata aagcaatcta ttggcataaa atagacggta
     9301 aaacttacta ttttggtgat attggagaga tggttgtcgg ttggcaatac ttagaaattc
     9361 ctggaacagg ttatcgtgat aatttattcg ataaccaacc agttaatgag attggccttc
     9421 aggagaagtg gtactatttt ggacaagatg gtgctttgct agaacaaaca gataaacaag
     9481 tactagagcc aaaaacgtct gaaaatacag gaaaagtata cggtgaacaa tatcctctat
     9541 ctgctgaaaa gagaacttat tattttgata ataattatgc tgtaaagaca ggctggattt
     9601 atgaagacgg caattggtat tatttaaata agctaggaaa ttttggcgat gattcttaca
     9661 atccactacc aattggtgaa gttgctaagg gttggactca agattttcat gttactattg
     9721 acattgatag aagcaaacct gctccatggt actacctaga tgcttcaggt aagatgctta
     9781 cagattggca aaaagtaaac ggaaaatggt attattttgg ctcctctggt tctatggcaa
     9841 caggttggaa atatgtacga ggcaaatggt attacttaga taataaaaat ggtgatatga
     9901 aaacaggatg gcaatacttt ggtaacaagt ggtactacct ccgttcatca ggagctatgg
     9961 taactggctg gtatcaagat ggtttaactt ggtactacct aaatgcaggt aatggagaca
    10021 tgacgacagg ttggttccag gtcaatggca gatggtacta cgcttatagc tcaggtgcct
    10081 tggcagtgaa tacgaccgta gatggctatt ctgtcaacta taatggcgaa tgggttcaat
    10141 aatgaaagaa gcgattgtga atggaaacaa tcgctttttt tgtgaaaata taataaaata
    10201 gataggaaag aattaatact tgtatgaaaa ataagacgtt ttttcgtcta gtaaaaggaa
    10261 aaaatgacaa aaaaagttgg tgtcggtcag gcacatagta agataatttt aataggggaa
    10321 catgcggtcg tttacggtta tcctgccatt tccctgcctc ttttggaggt ggaggtgacc
    10381 tgtaaggtag ttcctgcaga gagtccttgg cgcctttatg aggaggatac cttgtccatg
    10441 gcggtttatg cctcactgga gtatttgaat atcacagaag cctgcattcg ttgtgagatt
    10501 gactcggcta tccctgagaa acgggggatg ggttcgtcag cggctatcag catagcggcc
    10561 attcgtgcag tatttgacta ctatcaggct gatctgcctc atgatgtact agaaatcttg
    10621 gtcaatcgag ctgaaatgat tgcccatatg aatcctagtg gtttggatgc taagacctgt
    10681 cttagtgacc aacctattcg ctttatcaag aacgtaggat ttacagaact tgagatggat
    10741 ttatccgcct atttggtgat tgccgatacg ggtgtttatg gtcatactcg tgaagccatc
    10801 caagtggttc aaaataaggg caaggatgcc ctaccgtttt tgcatgcctt gggagaatta
    10861 acccagcaag cagaagttgc gatttcacaa aaagatgctg aaggactggg acaaatcctc
    10921 agtcaagcgc atttacattt aaaagaaatt ggagtcagta gccctgaggc agacttttgg
    10981 gttgaaacga ctcttagcca tggtgctctg ggtgccaaga tgagcggtgg tgggctagga
    11041 ggttgtatca tagccttggt aaccaatttg acacacgcac aagaactagc agaaagatta
    11101 gaagagaaag gagctgttca gacatggata gagagcctgt aacagtacgt tcctacgcaa
    11161 atattgctat tatcaaatat tggggaaaga aaaaagaaaa agagatggtg cctgctacta
    11221 gcagtatttc tctaactttg gaaaatatgt atacagagac gaccttgtcg cctttaccag
    11281 ccaatgtaac agctgacgaa ttttacatca atggtcagct acaaaatgag gtcgagcatg
    11341 ccaagatgag taagattatt gaccgttatc gtccagctgg tgagggcttt gtccgtatcg
    11401 atactcaaaa caatatgcct acggcagcgg gtctgtcctc aagttctagt ggtttgtccg
    11461 ccctggtcaa ggcttgtaat gcttatttca agcttggatt ggatagaagt cagttggcac
    11521 aggaagccaa atttgcctca ggttcttctt ctcggagttt ttatggacca ctaggagcct
    11581 gggataagga tagtggagaa atttaccctg tagagacaga cttgaaacta gctatgatta
    11641 tgttggtgct agaggacaag aaaaaaccaa tctctagccg tgacgggatg aaactttgtg
    11701 tggaaacctc gacgactttt gacgactggg ttcgtcagtc tgagaaggac tatcaggata
    11761 tgctgattta tctcaaggaa aatgattttg ccaagattgg agaattaacg gagaaaaatg
    11821 ccctggctat gcatgctacg acaaagactg ctagtccagc cttttcttat ctgacggatg
    11881 cctcttatga ggctatggac tttgttcgcc agcttcgtga gaaaggagag gcctgctact
    11941 ttaccatgga tgctggtccc aatgttaagg tcttctgtca ggagaaagac ttggagcatt
    12001 tatcagaaat tttcggtcat cgttatcgct tgattgtgtc aaaaacaaag gatttgagtc
    12061 aagatgattg ctgttaaaac ttgcggaaaa ctctattggg caggtgaata tgctatttta
    12121 gagccagggc agttagcttt gataaaggat attcccatct atatgagggc tgagattgct
    12181 ttttctgaca gctaccgtat ctattcagat atgtttgatt tcgcagtgga cttaaggcct
    12241 aatcctgact acagcttgat tcaagaaacg attgctttga tgggagactt cctcgctgtt
    12301 cgcggtcaga atttaagacc tttttcccta aaaatctgtg gcaaaatgga acgagaaggg
    12361 aaaaagtttg gtctaggttc tagtggcagc gtcgttgtct tggttgtcaa ggctttattg
    12421 gctctctata atctttcggt tgatcaggag ctcttgttca agctgactag cgctgtcttg
    12481 cttaagcgag gagacaatgg ttccatgggc gaccttgcct gtattgtggc agaggatttg
    12541 gttctctacc agtcatttga tcgccagaag gcggctgctt ggttagaaga agaaaacttg
    12601 gcgacagttc tggagcgtga ttggggattt tttatctcac aagtgaaacc aactttagaa
    12661 tgtgatttct tagtgggatg gaccaaggaa gtggctgtat cgagtcacat ggtccagcaa
    12721 atcaagcaaa atatcaatca aaatttttta agttcctcaa aagaaacggt ggtttctttg
    12781 gtcgaagcct tggagcaggg gaaagccgaa aaagttatcg agcaagtaga agtagccagc
    12841 aagcttttag aaggcttgag tacagatatt tacacgcctt tgcttagaca gttgaaagaa
    12901 gccagtcaag atttgcaggc cgttgccaag agtagtggtg ctggtggtgg tgactgtggc
    12961 atcgccctga gttttgatgc gcaatcaacc aaaaccttaa aaaatcgttg ggccgatctg
    13021 gggattgagc tcttatatca agaaaggata ggacatgacg acaaatcgta aggacgagca
    13081 tatcctctat gcccttgagc agaaaagttc ctataatagc tttgatgagg tggagctgat
    13141 tcattcttcc ttgcctcttt acaatctgga tgaaatcgat ctttcgacag agtttgctgg
    13201 tcgaaagtgg gactttcctt tttatatcaa tgccatgact ggtggaagta ataagggaag
    13261 agaaatcaat caaaagctgg ctcaggtggc ggaatcctgt ggtattttat ttgtaacggg
    13321 ttcttatagc gcagccctca aaaatccaac ggataattct ttttctgtca agtctagtca
    13381 tcccaatctc ctccttggaa ccaatattgg attggacaaa cctgtcgagt taggacttca
    13441 gactgtagaa gagatgaatc ctgttctatt gcaagtgcat gtcaatgtca tgcaggaatt
    13501 actcatgccc gagggagaaa ggaagtttag aagctggcaa tcgcatctag cagattatag
    13561 caagcaaatt cccgttccta ttgtcctcaa ggaagtgggc tttggaatgg atgccaagac
    13621 aatcgaaaga gcctatgaat tcggtgttcg tacagtggac ctatcgggtc gtggtggcac
    13681 cagctttgcc tatatcgaaa accgtcgtag tggccagcgt gattacctca atcaatgggg
    13741 tcagtctacc atgcaggccc ttctcaatgc ccaagaatgg aaagataagg tcgaactctt
    13801 ggttagtgga ggggttcgga atccgctgga tatgattaag tgcttggttt ttggtgctaa
    13861 gtctgtggga ttgtcacgaa ccgttctgga attggttgaa acctacacag ttgaagaagt
    13921 gattggcatt gtccaaggct ggaaagcaga cctacgcttg attatgtgtt cccttaactg
    13981 tgccaccata gcagatctac aaaaagtaga ctatcttctt tatggaaaat taaaagaagc
    14041 aaatgatcag atgaaaaagg cgtaaccagc gccttttttc catcctcaga ctgaggtgac
    14101 ttttttgaat tgtgataaaa tagaagggag aggatgaacc tatgagaaaa tttaaaatct
    14161 ttttatttat cgaagcctgt cttctgacag gagctctgat tttgatggta tcagagcatt
    14221 tttcgcgttt tctgctgata ctattcctct ttttgctttt gattcgctac tacactggta
    14281 aagaggggaa taatcttctt ttagtagcgg caaccattct cttctttttc attgttatgc
    14341 tcaatccttt tgtgattcta gctatttttg ttgcggttat ctatagtctc tttcttcttt
    14401 acccgatgat gaaccaggaa aaagagcaga ccaatttggt ttttgaagag gttgtgacgg
    14461 ttaagaagga gaaaaatcgt tggtttggaa atcttcatca tttttcaagc taccagactt
    14521 gccaatttga tgatatcaat ctctttcgct tcatgggcaa ggacactatt catctggaga
    14581 gagtcatctt aaccaatcat gacaatgtca ttatcctcag aaagatggta ggaacgacca
    14641 aaatcatcgt acctgtagat gtggaagtca gtctcagcgt taactgtctc tatggggatt
    14701 tgactttttt caaccagccc aagcgagccc tccgcaatga acactatcat caagaaacaa
    14761 aagactatct caagagtaac aagagtgtca agattttctt gaccactatg attggtgatg
    14821 ttgaggtggt tagaggatga aaaaacaagc ctatgtcatt atcgctctca cctccttcct
    14881 gtttgtcttt tttttctccc atagcttgct ggaaatactt gattttgact ggtctatctt
    14941 tttgcacgat gtcgaaaaaa cagaaaaatt tttcttttta ttgttggttt tcagcatgtc
    15001 catgacctgt ctcttagccc tgttttggcg agggatcgaa gagctttctc taagaaaaat
    15061 gcaggctaat ctcaagcgtt tattggcagg gcaagaagtg gttcaggttg tagatccaga
    15121 tttggatgcc agtttcaagt ccttatcagg taaacttaac cttttgacag aggctcttca
    15181 aaaagctgaa aatcatagcc ttgctcagga agaggaaatc atcgagaagg aacggaagcg
    15241 aattgctcgg gatttgcacg atacagtcag tcaggagttg tttgcggccc acatgatttt
    15301 atcgggtatc agtcagcagg ctttgaaatt ggatagagaa aagatgcaga cccagttgca
    15361 gagtgtcaca gctattttag aaacagccca gaaggatttg cgggttttgc tcttgcattt
    15421 gcgaccagtt gaactggagc agaagagctt gatagaaggg attcaaattc ttttaaaaga
    15481 gcttgaggac aagagtgatc ttagggttag tctcaagcag aatatgacga aattgcctaa
    15541 gaaaatcgag gagcatatct tccgtatcct gcaagagttg attagcaata ccctccgcca
    15601 tgcccaggca tcttgcctag atgtctacct ctatcagaca gatgttgaat tgcaactgaa
    15661 ggtggtggac aatgggattg gtttccagtt agggagctta gacgacttga gttatggact
    15721 gcgaaatatc aaggagcggg ttgaagatat ggctggaaca gttcaactct tgacagctcc
    15781 caagcaaggg ctggcggttg atatccgtat tcctctgtta gataaggaat gataaaggag
    15841 taaagatgaa aattttacta gtagatgacc atgaaatggt ccgattgggc ttgaaaagct
    15901 actttgacct ccaagacgat gtagaagttg tgggtgaggc gtccaacggg tctcaaggga
    15961 ttgacttggc cttggaactg cgtccagatg tcattgtcat ggatattgtc atgcctgaga
    16021 tgaatgggat tgacgcgacc ttagcaatcc ttaaagaatg gcctgaagcc aagattttga
    16081 ttgtgacctc ttatttggac aatgaaaaaa tcatgccagt cttagatgct ggtgccaaag
    16141 gctatatgct caagacttct agtgcagatg aattgcttca tgccgtcagt aaggtagctg
    16201 ctggcgagct ggccattgag caagaggtta gcaagaaggt tgaataccac cgcaatcata
    16261 tggaacttca tgaagaattg actgcgcgtg agcgagatgt tctccaactc atcgccaagg
    16321 gctacgaaaa tcagcgcatc gcagatgacc tctttatctc tctcaagacg gtcaagaccc
    16381 acgtgtccaa tattcttgcc aaacttgaag tcagcgatcg tacccaggcg gctgtctatg
    16441 cctttcagca ccatttggtg gggcaagagg agttttagat gagtttagca gatttacttg
    16501 aggagctaga agcagcaaaa gactctaaaa aagcaaggtc catggaagcc tatatgcgcc
    16561 atcaattttc ttttctaggt attgcggtgc ctgaaagaaa taaactctat aaaatatttt
    16621 ccagaagcga aaaaaacaaa gattatcgat tgggattttg cagacacttg ctgggaaaag
    16681 aatcctagaa aataccaata tgtggctgct aactatttga aagcaatgca gtcttatcta
    16741 aaggaaaccg atttgcctaa gctagagcag ttagtcgtga caaaatcctg gtgggacacg
    16801 gtagatatcc tagatcgagt agtagggagt ttggtgtatg aacactctga actagaagaa
    16861 ataatcttaa tactcttcga aaatctcttc aaaccacgtc agctctatct gcaacctcaa
    16921 aacagtgttt tgagcaatct gcggctagct tcctagtttg ctctttgatt ttcattgagt
    16981 ataaaatgga gcctatcaga taatatctgg ctgagacgtg tcgctattga ccaccagttg
    17041 ttaagaaaag agaagaccaa tactcaatta atggaaaaga ttctacttca taacttgaac
    17101 caaacagaat tttttatcaa taaagccatt ggctggactc tgcgagacta ctccaaaacg
    17161 aatcccactt gggtaacatg ctttattgag aaaaacaagg aaagaatggc tgaacttagt
    17221 atcaaagaag caagcaagta cctctagcgt gattgaaaag cgcagtcatt aattgaaaag
    17281 tttacctgtt tatgtgataa tggagggtat ttaaagaagg tggtagattt cttgattcta
    17341 tagtagatta agaaatttag aatagtacgc tataattaca ttaggaggat acaataatga
    17401 agaaaactgt ttataaaaaa ttgggtattt caattattgc gagtacttta ttggctagcc
    17461 agttatcgac agtatctgct ttgagtgtta tttctagtac aggtgaagaa tatgaggtaa
    17521 gtgagacact agaaaaaggt ccagagtcta atgattcttc attatctgag atttcaccaa
    17581 cgtatggttc atactaccaa aagcaatcag aagtattatc ggtaatgatg atttgattaa
    17641 aattgataat actttacagt atccgtattc gacttcagct atggttttat ctaagtatta
    17701 tggagtagcc gatggaatga atgtagaagg gaggggaagt gcgaatttta ttaaagataa
    17761 tgtgttaatt acagcggctc acaactacta cagacatgac tatgggaaag aagcggatga
    17821 tatttatgtt cttccggctg ttagtccaag tcaagaacta tttggaaaga tcaaagtaaa
    17881 ggaagttcgt tatttgaagg aatttagaaa tttaaattct aaggatgcaa gggaatatga
    17941 cttggcttta ttaattctag aagagcccat tggtgcaaaa ttagggactt tgggtcttcc
    18001 tactagtcaa aaaaatttga caggaataac tgtgactatc acaggctatc catcatataa
    18061 ttttaaaatt catcaaatgt atacagataa aaaacaagtt ttaagtgatg atggcatgtt
    18121 cttggattac caagttgata ctttagaggg gtctagtgga tctacagttt atgatgctag
    18181 tcaccgtgta gtaggagtgc atactttagg agatggagct aatcaaatta acagtgcagt
    18241 taaattaaat gaacgaaatt tgccatttat ttattcggtt cttaaaggtt actctcttga
    18301 aggatggaag aaaataaatg gtagttggta ccattataga caacatgata aacaaacggg
    18361 ttggcaggag ataaatgata cttggtatta tttagacagt tccggtaaga tgcttacaga
    18421 ttggcaaaaa gtaaatggaa aatggtatta tctcaattca aatggagcaa tggttacagg
    18481 tagccaaact atcgatggta aagtttataa cttcgcttca tctggtgagt ggatttaatg
    18541 ttggaggata tataaaatga agcttttgaa aaaaatgatg caaatcgcac tagccacatt
    18601 tttcttcggt ttgttagcga caaatacagt atttgcagat gattctgaag gatggcagtt
    18661 tgtccaagaa aatggtagaa cctactacaa aaagggggat ctaaaagaaa cctactggag
    18721 agtgatagat gggaagtact attattttga tcctttatcc ggagagatgg ttgtcggctg
    18781 gcaatatata cctgctccac acaagggggt tacgattggt ccttctccaa gaatagagat
    18841 tgctcttaga ccagattggt tttattttgg tcaagatggt gtattacaag aatttgttgg
    18901 caagcaagtt ttagaagcaa aaactgctac gaataccaac aaacatcatg gggaagaata
    18961 tgatagccaa gcagagaaac gagtctatta ttttgaagat cagcgtagtt atcatacttt
    19021 aaaaactggt tggatttatg aagagggtca ttggtattat ttacagaagg atggtggctt
    19081 tgattcgcgc atcaacagat tgacggttgg agagctagca cgtggttggg ttaaggatta
    19141 ccctcttacg tatgatgaag agaagctaaa agcagctcca tggtactatc taaatccagc
    19201 aactggcatt atgcaaacag gttggcaata tctaggtaat agatggtact acctccattc
    19261 gtcaggagct atggcaactg gctggtataa ggaaggctca acttggtact atctagatgc
    19321 tgaaaatggt gatatgagaa ctggctggca aaaccttggg aacaaatggt actatctccg
    19381 ttcatcagga gctatggcaa ctggttggta tcaggaaagt tcgacttggt actatctaaa
    19441 tgcaagtaat ggagatatga aaacaggctg gttccaagtc aatggtaact ggtactatgc
    19501 ctatgattca ggtgctttag ctattaatac cacagtaggt ggttactatt taaactataa
    19561 tggtgaatgg gttaagtaat gaagactaat tgtaaactgt gatggatact taactttgta
    19621 taataggtgg ataaaagtct tcacaatcaa aaaacgcata gtatcaaggt ttttctg
//
LOCUS       DBMVGT010000031        18800 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.031, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000031 DBMVGT010000000
VERSION     DBMVGT010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 18800)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18800)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18800
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.031"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..494)
                     /locus_tag="AC0DU4_001230"
     CDS             complement(<1..494)
                     /locus_tag="AC0DU4_001230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HIN4237191.1"
                     /translation="MTKLYGSLEAGGTKFVCAVGDENFNVVEKTQFPTTTPIETIDKT
                     IEFFSKFDNLAGLAVGSFGPIDIDKNSKTYGFITTTPKPNWANVDLLGALRRALNVPM
                     YFTTDVNSSAYGEMVARNNAGGRIENLVYYTIGTGIGAGVIQRGEFIGGVGHPEMGHY
                     YVAR"
     gene            complement(643..2526)
                     /locus_tag="AC0DU4_001231"
     CDS             complement(643..2526)
                     /locus_tag="AC0DU4_001231"
                     /EC_number="2.7.1.211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose-specific PTS transporter subunit IIBC"
                     /protein_id="HIN4237192.1"
                     /translation="MNNQEIAKKVIDALGGRENVNSVAHCATRLRVMVKDEEKINKEV
                     IENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVVLGLPTSSKDDMKAEVAKQGNWFQ
                     RAIRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPG
                     LVVWSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGS
                     VLPAFIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYI
                     LIATKAILSMPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAA
                     MTAQGAATVAVGVKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAG
                     AIGGGLASILGLAGTGNGITIIPGTMLYVGNGQLPQYLLMVAVSFALGFALTYMFGYE
                     DEVDATAAAKQAEVAEEKEEVAPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQG
                     IAVKPSQGVVYALADAEVSIAFPTGHAFGLKTRNGAEVLIHVGIDTVSMNGDGFEAKV
                     AQGNKVKAGDVLGTFDSNKIAAAGLDDTTMVIVTNTADYASVAPVATGSVSKGDAVIE
                     VKI"
     gene            2903..4357
                     /locus_tag="AC0DU4_001232"
     CDS             2903..4357
                     /locus_tag="AC0DU4_001232"
                     /EC_number="3.2.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004564 - beta-fructofuranosidase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="HIN4237193.1"
                     /translation="MEWTTERRYRLYQDWTQEEIQHIKENMAQSPWHTHYHVEPKTGL
                     LNDPNGFSYFDGKWILFYQNFPFGAAHGLKSWAQLESDDLVHFKETGIKVLPDTPLDS
                     HGAYSGSAMQFGDNLFLFYTGNVRDENWIRHPYQIGALMDKEGKITKIDKILIDQPAD
                     STDHFRDPQIFNFKGQYYAVVGGQDLEKKGFVRLYKAVNNDYTNWQAVGDLDFANDRT
                     AYMMECPNLVFVEEHPVLLYCPQGLDKKVLDYDNIFPNMYKIGASFDPKNAKMVDVSQ
                     LQNMDYGFEAYATQAFNAPDGRALAVSWLGLPDVSYPSDRFDHQGTFSLVKELTIKDD
                     KLYQYPVAAIKDLRASEEAFSNRSQTKNTYELELNLEANSQSEIVLLADKEGKGLSIN
                     FDLVNGQVTVDRSQAGEQYAQEFGTTRSCPIENQATTATIFIDNSVFEIFINKGEKVF
                     SGRVFPHADQNGILIKSGNPTGTYYELDYGRKTN"
     gene            4338..5303
                     /locus_tag="AC0DU4_001233"
     CDS             4338..5303
                     /locus_tag="AC0DU4_001233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002929307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HIN4237194.1"
                     /translation="MVAKLTDVAKLAGVSPTTVSRVINKKGYLSEKTIQKVNEAMREL
                     GYKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDS
                     EKEREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAG
                     GVLAAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKE
                     MEIKNILTREKPDAIFASDDLTAILVIKIAQELGISVPKELKVIGYDGTYFIENYYPQ
                     LATIKQPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI"
     gene            complement(5338..6612)
                     /locus_tag="AC0DU4_001234"
     CDS             complement(5338..6612)
                     /locus_tag="AC0DU4_001234"
                     /EC_number="1.1.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004420 - hydroxymethylglutaryl-CoA
                     reductase (NADPH) activity [Evidence IEA];
                     GO_function: GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_process: GO:0015936 - coenzyme A metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA reductase,
                     degradative"
                     /protein_id="HIN4237195.1"
                     /translation="MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTV
                     ADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFT
                     AQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVE
                     QIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSL
                     VTASCRIAFRYLSRQKDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIAT
                     GNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPVATKGGSIGLNPR
                     VALSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGA
                     SESEVAPLVERLISDKTFNLETAQRYLENLRS"
     gene            complement(6612..7784)
                     /locus_tag="AC0DU4_001235"
     CDS             complement(6612..7784)
                     /locus_tag="AC0DU4_001235"
                     /EC_number="2.3.3.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004181031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004421 - hydroxymethylglutaryl-CoA
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="HIN4237196.1"
                     /translation="MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSI
                     APLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFA
                     RSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAM
                     LITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQK
                     RYQLTLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGN
                     IYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLN
                     KLNQRTALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK"
     gene            complement(7915..8163)
                     /locus_tag="AC0DU4_001236"
     CDS             complement(7915..8163)
                     /locus_tag="AC0DU4_001236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237197.1"
                     /translation="MVSSWGSEFQSGWQEHQLIAEKVSKTLDKTFDKDVREIPTSQFY
                     QKFVDEMGRTYSGNLILQELITVNGAYKATYIGELSSN"
     gene            complement(8231..8854)
                     /locus_tag="AC0DU4_001237"
                     /pseudo
     CDS             complement(8231..8854)
                     /locus_tag="AC0DU4_001237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            complement(8916..9365)
                     /locus_tag="AC0DU4_001238"
     CDS             complement(8916..9365)
                     /locus_tag="AC0DU4_001238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HIN4237198.1"
                     /translation="MTLTTFLLQAVASFLAIITFLIVLNVQRSMLLPGGILGMTVWLI
                     YLLLKEPTNVIVATFIAAIIGSCVSQILSILYKTPAVVFILAILAPLVPGYLSYRTTA
                     FFVTGDYNKALASATLVVMLALVISIGMASGTVILRLYHYIKTHRVS"
     gene            complement(9367..10125)
                     /locus_tag="AC0DU4_001239"
     CDS             complement(9367..10125)
                     /locus_tag="AC0DU4_001239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HIN4237199.1"
                     /translation="MEESKELNTVIDVIMLAGTILLKSGSEIHRVEDTMIRIAHSQGI
                     VDCNVLAMPAAIFFSIENTNISRMKRVTSSSYNIEKVCDVNQISRQLVGGQIDLETAF
                     KQLTALQAQPLPYTKLQVTLAATFSAPFFSVMFSGNIYDALGAGVATLFGFAFSLYVE
                     KFIRIPFVTAFAGAFVFGIIAQFWARYTGFPSTADLIIAGAVMPFVPGIALTNAVRDI
                     MTNHINSGMSKMFESLLITLALGAGTSVALVLMN"
     gene            complement(10256..12235)
                     /gene="stkP"
                     /locus_tag="AC0DU4_001240"
     CDS             complement(10256..12235)
                     /gene="stkP"
                     /locus_tag="AC0DU4_001240"
                     /EC_number="2.7.11.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000614538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine-protein kinase StkP"
                     /protein_id="HIN4237200.1"
                     /translation="MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVL
                     RTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYI
                     KEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
                     FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAV
                     TIALQHFQKPLPSVIAENPSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYN
                     RRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKTPSQAVTEETYQPQ
                     APKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANF
                     EIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSD
                     VIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIVLTVAKKAT
                     TIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVS
                     KPIQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSAE
                     GMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP"
     gene            complement(12232..12972)
                     /locus_tag="AC0DU4_001241"
     CDS             complement(12232..12972)
                     /locus_tag="AC0DU4_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA];
                     GO_process: GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HIN4237201.1"
                     /translation="MEISLLTDVGQKRTNNQDYVNHYVNRAGRTMIILADGMGGHRAG
                     NIASEMAVTDLGVAWVDTQIDTVNEVREWFAHYLEIENQKIHQLGQDEAYRGMGTTLE
                     VLAIIDNQAIYAHIGDSRIGLIRGEEYHQLTSDHSLVNELLKAGQLTPEEAEAHPQKN
                     IITQSIGQKDEIQPDFGTVILESGDYLLLNSDGLTNMISGSEIRDIVTSDIPLADKTE
                     TLVRFANNAGGLDNITVALVSMNEEDAE"
     gene            complement(12987..14300)
                     /gene="rsmB"
                     /locus_tag="AC0DU4_001242"
     CDS             complement(12987..14300)
                     /gene="rsmB"
                     /locus_tag="AC0DU4_001242"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0001510 - RNA methylation [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HIN4237202.1"
                     /translation="MTKVETARSLALAVLEDVFVNQAYSNIALNKHLKGSQLSAADKG
                     LVTELVYGTVARKLTLEWYLSHFIEDRDQLDSWLYVLLLMSAYQLRYLDKIPDHAVVN
                     EAVELAKLRKKGSEKLVNAVLRRILREGWPDIASIKRKNKRDSIAYSLPVWLVAKLKE
                     EYGEERAKAIFESLLVRNKASIRVTDLSRKEEIQALLEANDSLLATTGLVKEQGHFAG
                     HNLFADGAITIQDESSQLVAPTLDLQGDERVLDACAAPGGKTAHIASYLTTGQVTALD
                     LYDHKLDLIQENAQRLGVEDRVQTQKLDARKVHEFFDQDSFDKILVDAPCSGIGLLRR
                     KPDIKYNKETADFASLQEIQLEILGSVCQILGKGGIITYSTCTIVSEENFQVVKAFLE
                     SHPEFEQVKLEHECKDIMKDGCILITPELYGSDGFFISQFRKISD"
     gene            complement(14293..15228)
                     /gene="fmt"
                     /locus_tag="AC0DU4_001243"
     CDS             complement(14293..15228)
                     /gene="fmt"
                     /locus_tag="AC0DU4_001243"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004479 - methionyl-tRNA formyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0071951 - conversion of methionyl-tRNA to
                     N-formyl-methionyl-tRNA [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HIN4237203.1"
                     /translation="MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKV
                     IQETPVKQAAKEAGLSIYQPEKLSGSPEMEDLMKLGADGIVTAAFGQFLPSKLLDSMD
                     FAVNVHASLLPRHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDED
                     NVGTLFEKLALVGCDLLLDTLPAYIAGDIKPEPQDTSQVTFSPNIKPKEEKLDWNKTN
                     RQLFNQIRGMNPWPVAHTFLKGDRFKIYEALPVEGQGNPGEILSIGKKELIVATAEGA
                     LSLKQVQPAGKPKMDIASFLNGVGRTLTVGERFGD"
     gene            complement(15241..17637)
                     /locus_tag="AC0DU4_001244"
     CDS             complement(15241..17637)
                     /locus_tag="AC0DU4_001244"
                     /EC_number="3.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001162119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HIN4237204.1"
                     /translation="MALAKIIVDVPLMQTDQPYSYRIPEEFEGMLEVGMRVHVPFGKG
                     NRLIQGIVLGLKSQSDGEEMEQDLKDIAEVLDFSPVLTPEQLWLAEELRKSVFSYKIS
                     ILKAMLPGFLNSSYDKILYPLEGLSQEERVRLFGSEDSLAFSSLDLAKQAEMMRLTRK
                     GLLGLEYQAVDQKKVKTQSWYEVDHAQLEGVEISTRAKKKLELRDYLLSHPESASLAS
                     LLESYSREQVNFFVDQGAVTIVQKEVQRSAAYFEGIEASRPLELNPEQRQARDAVVSS
                     IGSSQPPFLLQGITGSGKTEVYLQIIQGALDKGKTAILLVPEISLTPQMTERFIARFG
                     DKVAILHSGLSNGEKYDEWRKVERGDAQVVVGARSAIFAPLKNLGVMIIDEEHEAAYK
                     QDSNPRYHAREVAILRAQYNQATLVLGSATPSLESRARAGKGVYRHLRLTQRANPLAT
                     IPEVQVIDFRDYIGQNETSNFTPPLLEAIQDRLVKKEQVVLMLNRRGYSSFVMCRECG
                     TVDTCPNCDISLTLHMDTKTMNCHYCGFSKDIPQVCPNCKSRSIRYYGTGTQKAYDEL
                     AELFPQARILRMDVDTTRKKGSHQALLDQFGRGEADILLGTQMIAKGLDFPNVTLVGV
                     LNADTALNLPDFRSSERTFQLLTQVAGRAGRAEKAGQVLIQSYNSQHYAIRFAKDQDY
                     EGFYAYEMGIRRQLGYPPYYFTIGITLSHKKEEEVFKRAYEVMNILRSGLSETSPILG
                     PTPKPIARTHNLYHYQILIKYRLEDELGPTLNQVLALTQERENSELRLSIDHEPQQFL
                     "
     gene            complement(17703..18017)
                     /gene="rpoZ"
                     /locus_tag="AC0DU4_001245"
     CDS             complement(17703..18017)
                     /gene="rpoZ"
                     /locus_tag="AC0DU4_001245"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001817694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003899 - DNA-directed RNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HIN4237205.1"
                     /translation="MMLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSE
                     KSTLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKRRKEEEEKKIKEQIAKEKEDGE
                     KI"
     gene            complement(18042..18668)
                     /gene="gmk"
                     /locus_tag="AC0DU4_001246"
     CDS             complement(18042..18668)
                     /gene="gmk"
                     /locus_tag="AC0DU4_001246"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004385 - guanylate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006163 - purine nucleotide metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HIN4237206.1"
                     /translation="MADRGLLIVFSGPSGVGKGTVRREIFESSENQFQYSVSMTTRAQ
                     RPGEVDGVDYFFRTREEFEELIRQGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLE
                     IEVQGALQVKKKVPDAVFIFLTPPDLDELQDRLVGRGTDSAEVIAQRIEKAKEEIALM
                     REYDYAIVNDQVPLAAERVKCVIEAEHFCVDRVIGHYQEMLPKSPTTR"
BASE COUNT         5223 a         4363 c         3784 g         5430 t
ORIGIN      
        1 tgtctagcaa cataataatg acccatttca gggtgaccca caccaccgat aaactcacca
       61 cgttggatga cgcctgcacc gatacctgta ccgattgtgt agtaaaccaa gttttcgata
      121 cgaccaccag cattgttacg ggcaaccatt tcaccgtaag cagagctgtt tacgtctgtt
      181 gtgaagtaca ttggcacgtt tagggcgcga cgaagggcac caagcaagtc tacatttgcc
      241 cagtttggtt ttggagtcgt cgtgataaag ccataagttt ttgagttttt gtcaatatca
      301 atcggcccaa atgaaccaac tgcaagacca gcaaggttat cgaattttga gaagaactca
      361 atggttttat cgattgtttc gattggagtt gttgttggaa attgtgtttt ttctacaacg
      421 ttaaagtttt catcaccgac agcacagaca aactttgtac cgcccgcttc caagcttcca
      481 tataattttg tcatgataaa cctcttgttt ttattttctt tattatagca tacttcgaaa
      541 gtctaaatgt ctctattttt tagattttcc tctgtaaatc ttactatcta ataaaaacga
      601 acaaacatgt catttgttcg ttttcacatt agagaggatt gattagattt tcacttcgat
      661 cacagcatcc cccttcgaaa ctgaacctgt tgcgactgga gctactgaag cgtagtcagc
      721 tgtatttgta acgataacca ttgttgtatc atcaagtcca gctgcagcga ttttgtttga
      781 gtcaaatgtt ccaagaacat cgccagcttt caccttatta ccttgagcaa cttttgcttc
      841 aaaaccgtca ccgttcatag atacagtgtc aataccaacg tgaatcaaaa cttcagcacc
      901 atttcttgtt ttcaaaccaa aagcgtgccc tgttggaaag gcaattgaaa cttcagcatc
      961 agctagtgca tagaccacgc cttgacttgg tttcacagcg ataccttgtc ccatagctcc
     1021 acttgagaag actgggtcat tgacatcagc aagagcgaca acatcaccga cgataggagt
     1081 tacaagtgtt tcattttgaa gagctgctgg cgcaacttct tctttttctt cagccacttc
     1141 agcttgtttt gcagctgcag ttgcgtctac ttcatcttcg taaccaaaca tgtaagtaag
     1201 agcaaaacca agggcaaatg atacagctac cataagaagg tattgtggaa gttgtccgtt
     1261 accaacataa agcattgtac cagggatgat ggtgatacca ttaccagtac cagcaagtcc
     1321 aaggatagaa gccaatccac caccgattgc accagcaatc aatgaaagga agaatggttt
     1381 acggaagcgc aagttcaccc cgaagatagc aggctctgta atacctagga aggcagaaag
     1441 agcagccggg aaagcaagtg ttttcagttt tggatttttt gttttaacac caaccgcaac
     1501 agtagcagca ccttgagctg tcatagcagc tgtgatgata gcgttgaatg ggttagcatg
     1561 gtcagcagca agtaattgca cttcaagcaa gttgaagatg tggtgcacac ctgacacgac
     1621 gatcaattgg tgaaccccac caatcaagaa accaccaaga ccaaatggca tgctaagaat
     1681 cgcttttgta gcaataagga tgtagttttc aacaacgtgg aaaactggtc caatgacaaa
     1741 gagtccaagg atagacatga ccaaaagtgt cacgaatggt gttaccaaga ggtcaatgac
     1801 atctggaaca accttgcgga cagctttttc aaatttagct ccgacaaccc cgatgatgaa
     1861 ggctggaaga acggaacctt gcaaaccaac aacagggatg aaaccaaaga agttcatcgc
     1921 tgttacttca ccaccttgag caactgccca agcgtttgga agtgagccag agacaagcat
     1981 cataccaaga acgataccaa cggcaggatt tccaccaaat acacggaagg ttgaccacac
     2041 aaccaaacct ggcaagatga tgaaggctgt atctgtcaag atttgtgtgt aagttgcaaa
     2101 gtcacctgga agtggcattt caagagcgtt gaaaagacca cgcacaccca tgaagagacc
     2161 tgtcgctacg ataactggga tgattggaac gaaaacatca ccgaaagtac ggatagcacg
     2221 ttggaaccag ttcccttgtt tagcaacttc tgctttcatg tcatccttag atgatgttgg
     2281 taagccaagt acaacaactt catcgtacat tttgttaact gtacctgtac caaagataat
     2341 ttggtattgc cctgagttaa agaaagcacc ttgaactttt tccaagttct caatcacttc
     2401 tttattgatt ttctcttcat ctttgaccat gacacgtaga cgagtcgcac agtgggcaac
     2461 actattgaca ttttcacgtc cgcccaaggc atcgatgact ttttttgcaa tttcctgatt
     2521 gttcatttgc aaaaatctcc ttatataaca ttttgttctt gtttgaaagc gattttattc
     2581 gcccttacga ctattatttt atcatgtttt aaaaatatgt caagcgtttt gcagaaaaaa
     2641 tattctatcc acttagtggg caagttttag attgattgtt tttgactgtt tcatcaggaa
     2701 ttccttgaaa aataagtttg aaaccttggt taaaaagtct tttatttcat tatctttcac
     2761 attttcgtaa aaatttgatt gatttcctgt atttatttta tgataatcgt ttgacagttt
     2821 ttcctctttt ttaacataaa aggcttgcat tttttatcga aaacagttac tattaaaagt
     2881 gataagattt ttggaggaat gaatggaatg gacaactgag cgtcgttaca gactttatca
     2941 agattggacg caagaagaaa ttcaacatat aaaggaaaat atggcacaat ctccatggca
     3001 tactcattac catgttgagc caaaaacagg acttctcaac gacccaaatg gcttttctta
     3061 ctttgatggc aagtggatcc tcttttacca gaattttcct tttggtgcag cccacggttt
     3121 gaaatcttgg gcacagctag aaagtgatga tttggttcac tttaaagaaa ctggaatcaa
     3181 agttttacca gatactccat tagatagcca cggtgcctac tctggttctg ccatgcaatt
     3241 tggcgataac ttattcctat tttatacagg aaatgttcgc gatgaaaact ggatccgtca
     3301 cccataccag atcggtgctt tgatggacaa ggagggtaag attacaaaga ttgacaagat
     3361 cttgattgac cagccagcag actctactga ccacttccgc gatccacaaa tttttaactt
     3421 taaaggtcaa tactatgctg tcgtcggtgg acaggacttg gagaaaaaag gcttcgtccg
     3481 tctctacaag gctgtcaata acgactacac aaactggcaa gcagttggcg accttgactt
     3541 tgctaacgac cgtactgcct acatgatgga atgtcctaat ctggtctttg tagaggaaca
     3601 tcctgtcctt ctctactgtc cacaaggatt ggataagaaa gttctagact acgataatat
     3661 ctttccaaat atgtataaga ttggggcttc ctttgaccct aaaaatgcca aaatggtaga
     3721 tgtgtctcaa cttcaaaaca tggattacgg tttcgaagcc tatgcaactc aagccttcaa
     3781 cgctcctgat gggcgtgctc tagcagttag ctggcttggt ttgccagatg tttcttaccc
     3841 atctgaccgt tttgaccacc aaggaacctt ctctttggtc aaggaactca ctatcaaaga
     3901 cgacaagctc taccagtatc cagtcgctgc tattaaggac cttcgtgctt ctgaagaagc
     3961 cttctcaaac cgttcccaaa ccaagaacac ttacgaactt gaactcaact tggaagctaa
     4021 tagccagagc gagattgtct tacttgctga taaagaaggt aagggacttt caatcaactt
     4081 tgaccttgta aacggtcaag tgacagtgga tcgtagccag gctggagaac agtatgccca
     4141 agaatttggg acaactcgtt cttgccctat cgagaatcag gctactactg ctacaatctt
     4201 catcgataac tctgtctttg aaattttcat caataaagga gaaaaagtat tttctggtcg
     4261 tgtcttccca catgcggacc aaaatggtat cctgatcaaa tctggaaacc caactggaac
     4321 ttactatgaa ttagattatg gtcgcaaaac taactgatgt cgccaaactt gcaggcgtca
     4381 gtcctactac cgtttctcgg gttatcaata aaaaaggata tctatctgag aaaaccatcc
     4441 aaaaagtcaa tgaagccatg agagaattag gctataaacc caacaacctg gctcgtagtc
     4501 tgcaaggaaa atcagctaag ttaatcggct tgattttccc caatatttcc aatgttttct
     4561 atgcagaatt gattgataaa ttggaacacc aactcttcaa aaatggttac aagaccatca
     4621 tctgcaacag tgaacatgat tctgagaagg aacgcgaata catcgaaatg ttggaagcca
     4681 atcaggtaga cggcatcatt tctggtagtc acaacctagg aatcgaagac tacaatcgtg
     4741 tgacagcgcc gattatttcc tttgaccgaa acctatcgcc agacatccct gttgtctcct
     4801 ctgacaacta tgctggtggg gttcttgctg cccaaacctt ggtcaagaca ggtgcccagt
     4861 ctatcatcat gattacaggg aatgacaatt ccaattcgcc aaccggactg cgccacgctg
     4921 gttttgcatc cgtactccca aaagctccta ttatcaatgt ttccagtgac ttttctcccg
     4981 tcagaaaaga aatggaaatc aagaatatct tgacccggga aaaaccagat gccatttttg
     5041 cttcggatga tttgacagct attctggtca ttaaaatcgc tcaagaattg ggcatttctg
     5101 tcccaaaaga gctcaaggtc atcggctatg atgggaccta ctttatcgaa aattactacc
     5161 ctcaattggc tactatcaag caacctttgg aagagattgc ttgtctcact attgatcttc
     5221 tcttgcaaaa gattgaaggc aaggaagtcg ccacaactgg ttacttctta ccagttacgc
     5281 tattaccagg aaaaagtatt taaacacaag aaaactcaga ccgattcgtc tgagttttta
     5341 tgatcttaaa ttttcgagat agcgctgggc tgtctctagg ttaaaggttt tatctgagat
     5401 gaggcgctct actaggggag caacttcaga ttcactagcc ccagctagga gagctaggga
     5461 tttggcctgt agtttcatgt ggccttgctg gatgcccgta cttaccaagg ctttgagggc
     5521 tgcaaaattt tgagcaagac cgatggacac gataatctgg gctaattctc tggcagaagg
     5581 atttcctagt agatcatgac tgagagctac acgtgggttg aggccgatag agccaccctt
     5641 agtcgctaca ggcatgggca gggtcatctc accgaccaat tcttctcttt caaggtccag
     5701 cgtccagcag ctaagacctt gatagcgtcc atctcgactg gcaaaggcat gggccccagc
     5761 ttcgatggca cgccagtcat taccagtggc aatcaaaatc gcatcaatac cattaaaaat
     5821 tcctttatta tgagtagcag ctcggtaagg atcagcctgc gcaaactgac tagccaacgc
     5881 aattttctcc gcaatctctc gtccttgatc cttttggcgg ctcaagtagc gaaaggcgat
     5941 gcgacagctt gcagtcacca gagaatcagt cgcgtagttg gacaggattc ccatgagact
     6001 ctgtccctga ctgagttctt ctaagactgg tttcaaggct tccagcatgg tgttgagcat
     6061 attggcaccc atggcttcct gggtatcgac atgaatataa acaacgagaa agtctggttc
     6121 gccttttatc tgctcgacat gcagatcacg cgccccaccc ccacgtttaa cgatagaagg
     6181 ataggcttga ttggcaagct ccaagagctc cgctttcttg ctggcaatct tctcttgcgc
     6241 tagtttagga ttagcaactt gataaagggc tacctgccca atcatctggc gctgatggac
     6301 ttgtgcagta aaaccacctg cacgcttgat gattttgctg gcatagctgg ccgccgcaac
     6361 cacagagggt tcttctgtca catagggaac ggtgtattcc tgaccgttga caagtacctc
     6421 cggaaccagt gaataaggca gagaaaaagt tcccactaca ttctcactca gctggtctgc
     6481 cacagtcacg ctcatctgtt catccttctc cagactagct tgtctctcag gactaaggag
     6541 cgcctgagct tttaacagct cgaggcgctc ttggtatgat tttttagaaa atccattcca
     6601 acttatcttc attatttttc aaccttgcta taacggcgtt ggtggtcgag aatttcaacc
     6661 aaggcaaaat cttgattttc atagccagca aactgggcag agtttgtttc atccaagttt
     6721 acttcctcaa aaaagacctt ttcatagtct gcaacggata gggcagttcg ttggttgagc
     6781 ttgttcaaac ggtctttatc caaataagct tcatatcctt caaccaattc accactgaag
     6841 aactcagcca cagctccact tccgtaacta taaagggcga ttttatcccc agctttcaag
     6901 ctatctgtat tttccaagag agacaaaagt ccaaggaaaa gtgaacctgt gtagatattc
     6961 cccacctttt gactgtagag aatagactgg tcaaaatgct tttgtaagag gtcttttttc
     7021 tcttgaggca ggctcttatc catgattttt ttcaagcctt ttagcgctaa tttaggataa
     7081 ggcaagtgga aacaaacagc cgcaaaatca tccaaagtaa gctggtagcg tttttgatat
     7141 tcaagccaag tcgttttcaa actatccaag tattgttggg tagaatagac accatttaca
     7201 taaggagttg tcgagtaatt tggtcgccag aaatccatga tgtcacgggt ctgagctaca
     7261 ttgtcattat taaaggccat catgcgtgga ttttgtgtaa tcaacatagc cacacttcca
     7321 gcaccttgag ttggttctcc cggagtttca ataccatatt tggcaatatc actggcaatg
     7381 accaagacct tggactccgg agaattttcc acatgcaatt tggcataatg gagggcagct
     7441 gtcgccccat agcaggcttc tttaatctcg aaactacgag caaagggctg gatgcccagc
     7501 aagccatgca caaagacggc cgcagcctta ctctggtcaa ttcctgactc ggtagccaca
     7561 atgaccatgt caacttcttg tctttcttgc tcagttaaaa tagagtcact agcactggcc
     7621 gccaaggtca cgatgtcctc agttaggggc gcaatactca attccttgag taagagtcct
     7681 ttacttaatt tttcagggtc aattcccctc gcttctgcta agtcttgtaa tttcaagaca
     7741 tattgactgg tcgcaaaacc aatcttatca ataccgattg tcatatttac ctctgtttta
     7801 tcattcatgt aaaaaatcgt tctatactat tttatcacaa atggcagtaa aagagagaaa
     7861 aaagacttga ttcaccaaat caagcctctt attggtcatc attttaaaga atgattagtt
     7921 gctagagagt tcaccgatat aagtagcttt ataagctcca ttcacagtta tcagctcctg
     7981 gaggatcaaa tttcctgagt aagtccttcc catctcatct acaaattttt gataaaactg
     8041 actggtcgga atttctctga catccttatc aaatgtcttg tcaagtgttt tactaacctt
     8101 ctcagcaatc aattgatgct cttgccatcc actttgaaac tctgagcccc aactagaaac
     8161 catgactggg ataaacaaca aggtcagtag acttacagac aataaggaaa atagtagact
     8221 tcctgcaaaa ctagaatcct agttcatgat tgataatgcc agcaatcaaa ttcattcgta
     8281 atccgaagcg tttacgatga tttcgataga ttgttgaaaa cattttaaac gtttttactt
     8341 tggcaaagat gttctcaacc ttgcttctct ccttggatag cgcatggtta caagctttat
     8401 cttcagctgt tagcggcttg agtttgctgg atttacgtgg agtttgtact tgaggatata
     8461 tcttcatgag cccttgataa ccactgtcag acaagatttt accagcttgt ccgatatttc
     8521 tgcgactcat tttgaacaac ttcatatcat gacaatagtt cacagcgata tccaaagaaa
     8581 caattctccc ttgacttgtg acaatcgctt gagccttcat agcgtggcat ttctttttac
     8641 cagaatcatt cgctaattct tttttagggc gattgatttg tacttccgtc gcatcaatca
     8701 ttaccgtgtc ctcagaactg agaggagttc ttgaaatcgt aaaaccactt tgaacaagag
     8761 ttacttcaac ccattggctc cgacggatta agttgctttc gtggatacca aaatcagccg
     8821 caatttcttc ataagtgcgg tattctcgca catatagaaa gcgttgttaa tttatttatc
     8881 tcatttttca gaaaattctt tcatttgtgt aaagtctacg atactcgatg tgtttttata
     8941 taatgataca gtctgagaat cactgttccg ctagccattc caatagagat taccaaagcc
     9001 aacatgacaa ccaaggtcgc acttgccagt gctttattat agtcccctgt cacaaaaaag
     9061 gcagttgttc ggtaggagag ataacctgga accagcggtg ccaaaatggc caagataaag
     9121 accacagcag gtgtcttata aagaatactt aaaatctggc tgacacaaga accaataatg
     9181 gctgcaatga aggtagctac aatgacattg gtcggctcct tgagcaagag atagattagc
     9241 cagacagtca tgcccaaaat ccctccaggt aagagcatag accgttgcac attgagtacg
     9301 attaaaaaag tgataatggc aagaaaactt gctactgctt gtaataaaaa ggttgttagt
     9361 gtcatattag ttcatcaata ccaaggcgac agaagttcct gcccctaaag cgagggtaat
     9421 gagcagggat tcaaacatct tactcatacc agagtttatg tggttggtca taatatcacg
     9481 gaccgcattg gtcaaggcaa tacctggtac aaacggcatg accgcaccag ctataatcaa
     9541 atctgccgtt gaaggaaaac ctgtgtagcg agcccaaaac tgggcaatta tcccaaagac
     9601 aaaggctcca gcaaaggctg tcacaaaggg aattcggata aatttttcca catagaggga
     9661 aaaggcaaaa ccaaataagg tcgccactcc tgccccaagt gcgtcgtaga tatttccgct
     9721 aaacataact gaaaagaaag gagcgctaaa ggtcgcagcc agagttacct gcaacttagt
     9781 atagggaagg ggttgagctt gcaaggccgt caattgctta aaggctgttt ctaaatcaat
     9841 ctgcccccca accagctgac gagaaatctg gttcacatcg cagacttttt cgatgttata
     9901 agaagaggag gtcacgcgct tcatgcgcga aatattggta ttttcaatag agaaaaagat
     9961 agcggcaggc atggcaagga cattgcaatc cacaatcccc tgcgaatgcg cgattcgaat
    10021 catggtatct tctacacgat ggatttctga gccactttta aggagaatag tccccgctag
    10081 cataatcaca tcaatgacgg tatttaattc ttttgattct tccatgcttt cctcctttta
    10141 tcaactccct ctattctatc acaaatccgg actcaaaaaa aatctttgcc atgaaatcat
    10201 gacaaagatt gattactcat tttgattatc catctgcttg attatccatc tgcttttaag
    10261 gagtagctga agttgtttta ggtttgtaga ttgaaatctt gactctagtc ttattgaggt
    10321 ctaccttttc acctgctcta ggactttgtt caacaaccat gccttctgca ctacctgcag
    10381 gcgctgtcgt cacttctaca acttctatat tagcttcctt aatcccaaca atttgaatca
    10441 aattgttctt agtaaactcc aagctggaac caatgtaact cggcatggca acacttgtaa
    10501 cttttttagc tactgtcaag acaatttgaa taggtttact cacatcatag gtcgttccgg
    10561 cacctggact ttgtttcata atcgttcctg gttcgctttc gctggactct tcttcctcta
    10621 tcttaatcaa attctcagga accttcttct gcttgagttc tgagattact tctgtagagt
    10681 tccgtccaat atagttccct aattgaatcg tcgtagcttt tttagctact gtcaaaacaa
    10741 tttgagttgc cttgctcaag tcataggtcg taccttctgg tagactttgc ttcaggaccg
    10801 ttccagcctc actctcattg gactcttctt cctcaatttt aatcaaatta tctggaactt
    10861 ttttctcttt taattccgca atgacatcag aggatttccg accgacataa ttactaattt
    10921 ggaaggattg cttgcctgat gagacaacca aattgatttt cgttccttct tttcgaccag
    10981 ttccagcgcc aggatctgta cggataatcc gcccttcttc caccttttca ctagcctctg
    11041 tcttctcctc accaatctca aaattggctt ttttgagcgt tgccttggcc tctgcaactg
    11101 tctgacctgc cacatctgga atggcaatgg ttgcaggagt tctggatagt atccaaataa
    11161 gagaagctgc caccaataca aggctggcca acaaaatcag gtaacgcatc ttaaatctat
    11221 gttttttcgg tgcttgtggt tggtaagttt cctctgtcac agcctggctt ggggttttga
    11281 ttgatttgtg ttctgtctgc gcttgaacct taggaataga tgtcaaggta ctctgagaaa
    11341 ccttcggcaa ggtcttggta tctgccttgc tcgtttcatc aaagattaac ttactttcat
    11401 ttctacgatt gtaggacaag ctactagaca agtccacata catctctgaa accgagcggt
    11461 agcgattggt caacttttta gcagttgcct tgataataac attttctaaa gcctgaggta
    11521 cagatggatt ttctgcaata acggacggca ggggtttctg gaaatgctgg agggcaatgg
    11581 tcaccgcgct atccccgtca taagggatat ggcctgtcaa catctcatag aaaataatcc
    11641 ccatagcata gatatcactc tgcacagtcg ccttcgaacc acgcgcctgc tctggggaca
    11701 agtaatgaac tgagcccaac atcgagttag tctgggtcag acttgtctct gcaaaggcta
    11761 cagcaatccc aaagtctgtg acctttgcag tcccatctgg tgtcaaaagg atattttgag
    11821 gtttcaagtc cctgtgaaca attcctctgg tatgggccaa acgcatggct aggaggattt
    11881 gtcccatgat acggactgct tcttcattag aaagaggata atgttccttg atatagcgtt
    11941 tgaggtctag tccagcaaca tactccattg caagatactg ttgaccgtct tcctcaccaa
    12001 tatctgttat ccgaacgata tgaggatggt ctagatctgc catagctctc gcttcacgct
    12061 gaaaacgagc tacagctatc gggtccgtct ggtagttggt cctcagaacc ttcactgcca
    12121 cttcttcccc atctaagatt aagtctttgg ctaggtagac atccgccata cctcctcgac
    12181 caatctgttt gacaatccga tagcgtccgg caaaaatctt gccgatttgg atcattctgc
    12241 atcctcctcg ttcatagaaa caagggcaac cgtaatgttg tctaaacctc ctgcattgtt
    12301 agcaaaacga acaagtgtct ccgttttatc tgctaaagga atatcactgg ttacaatatc
    12361 acgaatctca ctgcctgaaa tcatgttggt caagccgtca ctattgagca agagatagtc
    12421 acctgactca aggataactg tcccaaaatc aggctgaatt tcatcttttt gcccaataga
    12481 ctgggtgata atattttttt gcggatgagc ttctgcctct tctggtgtca attgaccagc
    12541 cttgagcaat tcattaacca aggaatgatc gctcgtcaac tgatggtatt cttctccacg
    12601 aatcaagccg atacgcgaat caccaatatg agcatagata gcctgattat caataatagc
    12661 aaggacttcc aaagtagttc ccatgcctct gtaagcttca tcctgaccaa gctggtgaat
    12721 cttttgattt tcaatttcta ggtaatgggc gaaccattca cgcacttcat tgactgtatc
    12781 gatctgggta tcaacccaag ctacacccag gtctgtgacc gccatttcac tagcgatatt
    12841 ccctgcacga tgacctccca tcccatcagc taaaataatc atggtacgtc cagctctatt
    12901 gacatagtgg ttgacatagt cttggttatt tgttcgtttc tgaccaacat ctgttaataa
    12961 tgaaatttcc atgtgtcagt tccttcctaa tccgatatct tgcgaaattg actgatgaag
    13021 aatccatcac ttccatacaa ttcaggtgta atgaggatac agccgtcttt catgatatcc
    13081 ttacattcat gttctagttt tacctgctcg aactcgggat gactctctaa aaaggcctta
    13141 acgacttgaa aattctcctc tgagacgata gtgcaggtgc tataagttat tataccacct
    13201 ttgcctagta tttgacaaac actacctaat atttctaact gaatttcctg caaggacgcg
    13261 aaatctgccg tttctttatt gtatttgata tctggttttc ggcgcaaaag accgattcct
    13321 gaacaaggag catccaccaa aatcttatca aaggaatcct ggtcaaaaaa ctcatgcacc
    13381 tttctggcat ccaatttttg agtttgaacc cgatcttcaa ctcccagacg ttgggcattt
    13441 tcttgaatta aatccaactt gtggtcgtac aagtccagag cagtaacctg acctgtcgta
    13501 agataagagg ctatatgggc tgttttccca cctggagccg cacaggcatc aagcactcgc
    13561 tcatcacctt gtaaatcaag cgtcggagca accagctgac tggactcgtc ttggatggta
    13621 atggctccat ccgcaaacaa attatgccct gcaaaatgcc cctgctcctt aaccagacca
    13681 gtggttgcta aaagggaatc attcgcctcc aacaaggctt ggatttcctc ttttcgactt
    13741 aggtctgtta cacgaatact ggctttgttt cgcactaaca ggctttcaaa gatggctttt
    13801 gctctctcct ctccgtattc ttccttgagt ttggcaacta gccaaactgg gagagaatag
    13861 gcaatggagt cacgcttgtt ttttcgcttg atgctagcaa tatctggcca gccttcacgc
    13921 aagatacggc gaaggacagc gttgaccaat ttttcactgc cttttttacg gagtttggct
    13981 aattccactg cttcattgac cacagcatga tctggaattt tgtccaaata gcggagttgg
    14041 taggcactca tgagaagaag gacatagagc cagctgtcta actggtctct gtcttcgata
    14101 aagtgggata ggtaccattc cagagtcagt ttacgggcta ccgttccata gactagctcg
    14161 gtcactaagc ccttgtctgc tgcagagagc tgactcccct tgaggtgttt atttaaggca
    14221 atatttgaat atgcttgatt cacaaaaaca tcctctagca ctgctagagc taaacttcta
    14281 gccgtttcta ctttagtcac caaatcgttc tcctacagtc aatgtacgtc caactccatt
    14341 gaggaaggaa gcaatgtcca tcttaggctt accagctggc tgcacttgtt tgagggatag
    14401 agccccttca gccgttgcga caatcaattc tttcttgccg atagagagaa tctcacctgg
    14461 atttccctga ccttctactg gtagggcttc ataaatctta aagcggtcgc ccttaaggaa
    14521 agtatgggca acaggccagg ggttcattcc acgaatttgg ttaaagagtt gacgattggt
    14581 tttgttccag tccagttttt cttcctttgg ctttatattt ggagaaaagg taacctgact
    14641 cgtatcctgc ggttcaggtt tgatatcacc agcaatatag gcaggcagag tgtccaaaag
    14701 caaatcacaa ccaactagcg ccaatttttc aaacaaggtg ccaacattgt cctcatctgt
    14761 gatcggaatg ctgcgacgag aaatcatatc tcctgcatcc atttccttaa ccatttccat
    14821 gatggtcaca ccagcttcct catccccttg aatcaaggca taatggatag gcgcaccacc
    14881 acggtgtcta ggaaggaggg aggcatgaac gttgacagca aagtccatgc tatcaaggag
    14941 tttgcttggg agaaactgcc caaaagcagc agtcacaatt ccatctgctc ctagcttcat
    15001 aagatcttcc atctctggac ttccagataa tttttcaggt tggtagatag atagtcctgc
    15061 ttccttggca gcctgcttga ctggggtttc ttggataact tttttacgac caacagcacg
    15121 gtctggctgg gtcacaacgg ctagaatttc gtaacggtca tctgtcaaaa gtccttttaa
    15181 gactgttgct gaaaagtcgg gggtccccat aaagattagt tttgtcatat cttctccttc
    15241 ttataaaaat tgctgcggct catggtcaat gctgagacgg agctcactat tttcccgttc
    15301 ttgagtcaag gccaagacct ggttgagggt cggccccagc tcatcttcta aacggtattt
    15361 aattaaaatc tggtaatgat agaggttgtg ggtacgggca atcggttttg gcgttggccc
    15421 cagaatggga ctggtctctg acaagcctga ccgcaaaatg ttcatgactt cataggcacg
    15481 tttgaaaacc tcttcttctt tcttgtgaga aagggtaata ccaatcgtga aatagtaagg
    15541 tggatagccg agttgtcgtc tgattcccat ttcataggca taaaagcctt cgtaatcttg
    15601 atccttggca aatcgaatag catagtgctg cgaattgtag gactgtatca agacttgacc
    15661 tgctttttca gcccgacctg ctcgacctgc cacctgagtc aagagctgga aggttctctc
    15721 agaagaacgg aaatcaggca gattcaaggc cgtatccgca tttagaactc cgactagggt
    15781 aacattggga aaatccaaac cctttgcaat catctgagta ccaagtaaaa tatccgcttc
    15841 ccctcgccca aactggtcaa gcaaggcttg gtgactgcct ttctttcgag tcgtatccac
    15901 atccatcctc aaaatgcgag cttggggaaa gagttctgct agctcatcat aagccttctg
    15961 agttcccgtc ccatagtaac gaatactgcg gctcttacag ttaggacaga cctgaggaat
    16021 atccttcgag aaaccacaat aatggcagtt catagtcttg gtatccatat gcaaggtcag
    16081 agaaatatcg cagttgggac aagtatccac cgtcccacac tcccgacaca tgacaaagct
    16141 agaataacca cggcgattga gcatgagaac cacctgctct tttttaacca gacggtcttg
    16201 gatagcctct agcaaaggag gcgtaaagtt tgacgtctca ttttgtccga tatagtctcg
    16261 aaagtcaatc acttgaacct cagggattgt agccaaagga ttggcacgtt gggttagacg
    16321 taagtgtcga tagacgcctt tgccagcacg tgcccggctc tctaagctcg gcgttgcaga
    16381 tccaagtacc agagttgctt gattatactg agcccgtaaa atagctacct ctctggcatg
    16441 gtaacgggga ttgctgtcct gcttataagc cgcttcatgc tcttcatcaa taatcatgac
    16501 acccagattt ttcagaggag caaagatagc agatctggca ccaacaacaa cttgggcatc
    16561 gccacgctcc accttgcgcc attcatcata cttttcgcca ttggataatc ctgagtgaag
    16621 aatggctacc ttgtccccaa aacgtgctat aaaacgctcg gtcatctgag gagtcaagga
    16681 aatctcaggt accagcaaaa tagctgtctt acccttatcc agggcacctt ggataatctg
    16741 caagtaaacc tcggtcttcc cacttcctgt aatcccttga agtagaaagg gaggttgaga
    16801 actgccaata gaactcacaa ccgcatcacg cgcctgtctt tgttctggat ttaactccaa
    16861 aggtctactt gcttcaattc cttcaaaata agcagccgag cgttgaactt ccttttggac
    16921 tatggtaaca gcaccttgat ccacaaagaa gttgacttgc tctcgcgagt aggactctaa
    16981 caagctagcc aaggaagcgc tctctggatg agacagcaga taatctctca gttccaactt
    17041 tttcttggca cgtgtagaaa tctcaacacc ttctaattgg gcatggtcaa cctcatacca
    17101 agactgggtc ttgaccttct tttgatcgac tgcctgatat tccagaccaa gcaggccttt
    17161 tctagtcaaa cgcatcattt cagcttgctt ggcaaggtct agtgaagaaa aggctagcga
    17221 atcttctgaa ccaaacaggc gtactcgttc ttcctgactc aagccttcca gaggatagag
    17281 aatcttgtca tagctagaat tcagaaaccc tggaagcatg gccttgagga tagagatttt
    17341 gtaggagaag acagatttgc gtaactcctc agccagccag agttgttctg gcgtgagaac
    17401 aggagaaaaa tccagcacct ctgcaatatc ttttaaatct tgctccatct cttctccatc
    17461 tgattgggac ttcaaaccaa gaacaatccc ttgaatcagg cgattcccct taccaaaagg
    17521 cacatgaacc cgcatcccaa cttccagcat tccctcaaat tcctccggaa tcctgtaact
    17581 atagggctgg tccgtctgca tcaagggcac atctacgata atcttagcta gggccatctt
    17641 ctcacctcct ccttgtcagt acattcttgc aatagaaaaa ataagattga gtccccccaa
    17701 ccttaaattt tttcaccatc ttctttttct ttagcaattt gctctttgat tttcttttct
    17761 tcttcttctt tgcggcgttt ttcttcttcg atacggcgac gcactgcttc acgttttcct
    17821 tctggatctg ggtgaattgt aacgtttcct gattcgattt cttctaaagc gcgaagagtt
    17881 gatttttcag acttgaaacc ttgagttgct ggggcacctg cttccaattc gtgggcacgt
    17941 tttgcttcca agattacgag tgaatatttt gaaggaacct tgtcgagcaa ggtatcaata
    18001 gagggtttta acatcatttg cttgtaccta ttttctaaat tttatcgggt agttggagat
    18061 tttggtaaca tctcctgata gtgaccaatg acacgatcca cacagaagtg ttctgcttca
    18121 atcacacatt tgacacgttc agcagctagg ggcacctgat cgttgacaat cgcataatca
    18181 tactcacgca tgagggcaat ttcttccttg gccttttcga ttcgttgggc aatcacttct
    18241 gcactatctg ttccacgacc taccaagcga tcttgcaatt catccaaatc tggtggtgtc
    18301 aggaagataa agacagcatc tggaaccttt ttcttgacct gaagagcacc ctgaacttca
    18361 atttcaagga aaacatcgat tcccttgtcc aaggtttcat tgacataggt cagaggagtt
    18421 ccatagtagt tgccgacata ttctgcgtat tccaacatct gtccttgacg aatcagctct
    18481 tcaaattctt cacgagtacg gaagaaatag tcaacaccgt ccacttctcc aggacgttgt
    18541 gcgcgtgtcg tcatcgatac agaatattga aattggtttt cagaactctc aaaaatctct
    18601 cttctaaccg ttccttttcc aacccctgaa ggaccagaaa aaacgattag taagcctcgg
    18661 tctgccattg tgtctccttt tagtcaatct gtgaaataac atttctctag aataatggca
    18721 aaaagccaga ttatccttta cagtctttct atctagtgta acaaaaaagc agtaattttt
    18781 caactgctct ttcttattta
//
LOCUS       DBMVGT010000032        18181 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.032, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000032 DBMVGT010000000
VERSION     DBMVGT010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 18181)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18181)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18181
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.032"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..508
                     /locus_tag="AC0DU4_001247"
     CDS             <1..508
                     /locus_tag="AC0DU4_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234238.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="aldose 1-epimerase family protein"
                     /protein_id="HIN4237207.1"
                     /translation="RKSNKETSKVRPYFIGGHPGFNCPLLDDEVYEDYYLEFEKEETC
                     SVPRPFPETGMLDFQDRSPWLEGQKEIDLSYDLFSTDAVTLDELQSRTIALRSLKHDK
                     GLKVHFAEFPNLIIWSTLNKGPFITFEPWSGLSTSLEEGDHLEDKKNVCLLEANQVEE
                     LGFEIEVL"
     gene            665..1090
                     /gene="lacA"
                     /locus_tag="AC0DU4_001248"
     CDS             665..1090
                     /gene="lacA"
                     /locus_tag="AC0DU4_001248"
                     /EC_number="5.3.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050044 - galactose-6-phosphate isomerase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="HIN4237208.1"
                     /translation="MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTL
                     AVAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMIT
                     MGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG"
     gene            1121..1636
                     /gene="lacB"
                     /locus_tag="AC0DU4_001249"
     CDS             1121..1636
                     /gene="lacB"
                     /locus_tag="AC0DU4_001249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="HIN4237209.1"
                     /translation="MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPI
                     FGKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNAN
                     VIGFGGKITGELLMCDIIEAFIHAEYKPSEENKKLIAKIEHLESHNAQQTDANFFTEF
                     LEKWDRGEYHD"
     gene            1647..2576
                     /locus_tag="AC0DU4_001250"
     CDS             1647..2576
                     /locus_tag="AC0DU4_001250"
                     /EC_number="2.7.1.144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000604270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009024 - tagatose-6-phosphate kinase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="HIN4237210.1"
                     /translation="MILTVTMNPSIDISYPLDELKIDTVNRVVDVTKTAGGKGLNVTR
                     VLSEFGDSVLATGLVGGKLGEFLVEHIDNQVKKDFFSIQGETRNCIAILHGDNQTEVL
                     EKGPEVLEQEGQDFLEHFKKLLESVEVVAISGSLPAGLPVDYYASLVELANQAGKPVV
                     LDCSGAALQAVLESPHKPTVIKPNNEELSQLLGREVSEDLDELKEVLQEPLFAGIEWI
                     IVSLGANGTFAKHGDTFYKVDIPRIQVVNPVGSGDSTVAGISSGLLHKESDAELLIKA
                     NVLGMLNAQEKMTGHVNMANYQALYDQLIVKEV"
     gene            2578..3558
                     /gene="lacD"
                     /locus_tag="AC0DU4_001251"
     CDS             2578..3558
                     /gene="lacD"
                     /locus_tag="AC0DU4_001251"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009025 - tagatose-bisphosphate aldolase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="HIN4237211.1"
                     /translation="MALTEQKRVRLEKLSDENGIISALAFDQRGALKRLMAQHQTEEP
                     TVAQMEELKVLVADELTKYASSMLLDPEYGLPATKALDEKAGLLLAYEKTGYDTTSTK
                     RLPDCLDVWSAKRIKEEGADAVKFLLYYDVDSSDELNQEKQAYIERIGSECVAEDIPF
                     FLEILAYDEKIADAGSVEYAKVKPHKVIGAMKVFSDPRFNIDVLKVEVPVNIKYVEGF
                     AEGEVVYTREEAAAFFKAQDEATNLPYIYLSAGVSAKLFQDTLVFAHESGANFNGVLC
                     GRATWAGSVEAYIKDGEAAAREWLRTTGFENIDELNKVLQRTATSWKERV"
     gene            3964..4440
                     /locus_tag="AC0DU4_001252"
     CDS             3964..4440
                     /locus_tag="AC0DU4_001252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237212.1"
                     /translation="MNVDGNKFYNVSVSEDIVNAGQILEDYFYVDKFGNINLKGTPEE
                     LAKNIGISVQEASLMYEAVKELPNVYERGPVGFRFNLGPQVRGMGGWAAGAFATGYAG
                     WHLKQFAVNPVTSGFVAVISGAIGWAVKTAVENYWTVAVATVEVPFVNLVYTIDLP"
     gene            4838..5674
                     /locus_tag="AC0DU4_001253"
     CDS             4838..5674
                     /locus_tag="AC0DU4_001253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HIN4237213.1"
                     /translation="MYRILNPMNHNVSLVRNDKGEEVIIIGKGIAFGKRKGDLIAENQ
                     VEKIFRMKTEESRENFMALLKDVPLDFITVTYEIIDKLSKKYHYPIQEYLYVTLTDHI
                     YCSYQALTQGRYKDSNLPDISAKYPVAFQIANEAFEIYRQKLADHFPEDEIIRIAYHF
                     INAEGENEVELVESIDKRKEILRNVEEVLKGYAIQRTKKNNHFYDRFMIHLNYFLDYL
                     DRSRDDNQSLLDMEDHIKQSYPKAFEIGSKIYDVITQHTGLDLYKSERVYLVLHIQRL
                     LS"
     gene            5710..6027
                     /locus_tag="AC0DU4_001254"
     CDS             5710..6027
                     /locus_tag="AC0DU4_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HIN4237214.1"
                     /translation="MNREEVTLLGFEIVAYAGDARSKLLEALKAAEAGDFEKADALVE
                     EAGSCIAEAHHAQTSLLTKEASGEDLAYSVTMMHGQDHLMTTILLKDLMHHLIELYKR
                     GVK"
     gene            6027..7718
                     /locus_tag="AC0DU4_001255"
     CDS             6027..7718
                     /locus_tag="AC0DU4_001255"
                     /EC_number="2.7.1.207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0019197 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase complex [Evidence IEA];
                     GO_function: GO:0015155 - lactose transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lactose-specific PTS transporter subunit EIIC"
                     /protein_id="HIN4237215.1"
                     /translation="MNKLIAFIEKGKPFFEKLSRNIYLRAIRDGFIAGMPVILFSSIF
                     ILIAFVPNSWGFKWSDEVVAFLMKPYSYSMGILALLVAGTTAKSLTDSVNRSMEKTNQ
                     INYMSTLLAAIVGLLMLAADPIESGLATGFLGTKGLLSAFLAAFVTVAIYKVCVKNNV
                     TIRMPDEVPPNISQVFKDVIPFTLSVVSLYALDLLARHFVGSSVAESIGKFFAPLFSA
                     ADGYLGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAEVNLNLLQQGMHADKILT
                     SGTQMFIVTMGGTGATLVVPFMFMWLTKSKRNRAIGRASVVPTFFGVNEPILFGAPLV
                     LNPIFFIPFIFAPIANVWIFKFFIETLGMNSFTANLPWTTPAPLGLVLGTNFQVLSFI
                     LAALLIVVDVVIYYPFLKVYDEQILEEERSGKSNDELKEKVAANFNTAKADAILEKAG
                     VEAAQNTITKETNVLVLCAGGGTSGLLANALNKAAAEYNVPVKAAAGGYGAHREMLPE
                     FDLVILAPQVASNFEDMKAETDKLGIKLAKTEGAQYIKLTRDGKGALAFVQAQFD"
     gene            7927..9333
                     /gene="lacG"
                     /locus_tag="AC0DU4_001256"
     CDS             7927..9333
                     /gene="lacG"
                     /locus_tag="AC0DU4_001256"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033920 - 6-phospho-beta-galactosidase
                     activity [Evidence IEA];
                     GO_process: GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HIN4237216.1"
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWY
                     TAEPASDFYNRYPVDLKLAEEYGVNGIRISIAWSRIFPTDYGQVNAKGVEFYHNLFAE
                     CHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVDYAAFCFEEFPEVNYWTTFNE
                     IGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLYKEKGYKGEIGVVHAL
                     PTKYPLDPENPADVRAAELEDIIHNKFILDATYLGRYSAETMEGVNHILSVNGGSLDL
                     REEDFTALEAAKDLNDFLGINYYMSDWMEAFDGETEIIHNGKGEKGSSKYQIKGVGRR
                     VAPDYVPRTDWDWIIYPQGLYDQIMRVKKDYPNYKKIYITENGLGYKDEFVDNTVYDD
                     GRIDYVKQHLEILSDAIADGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFETQERY
                     PKKSAHWYKKVAETQIID"
     gene            9376..9633
                     /locus_tag="AC0DU4_001257"
     CDS             9376..9633
                     /locus_tag="AC0DU4_001257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000471575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3884 family protein"
                     /protein_id="HIN4237217.1"
                     /translation="MFKDFIQSIYEKVYIINFEKCSQIPCLTSEELKSLGKWYVSTGK
                     EWICHSDDELEEFKNLFLNFINPEGWDTISFDSDFMPFQQS"
     gene            complement(9912..10673)
                     /locus_tag="AC0DU4_001258"
     CDS             complement(9912..10673)
                     /locus_tag="AC0DU4_001258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000917571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="HIN4237218.1"
                     /translation="MLKQEKLAKILEIVNSKGTITVKQIMDEIAVSDMTARRYLQELA
                     DKDLLIRVHGGAEKLRTNSLLTNERSNIEKQALQTAEKQEIAHFAGSLVEERETIFIG
                     PGTTLEFFARELPIDNIRVVTNSLPVFLILSERKLTDLILIGGNYRDITGAFVGTLTL
                     QNLSNLQFSKAFVSCNGIQNGALATFSEEEGEAQRIALNNSNKKYLLADHSKFNKFDF
                     YTFYNVSNLDTIVSDSKLSDSILFKLSKHIKVIKP"
     gene            complement(10855..11817)
                     /gene="nrdF"
                     /locus_tag="AC0DU4_001259"
     CDS             complement(10855..11817)
                     /gene="nrdF"
                     /locus_tag="AC0DU4_001259"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA];
                     GO_function: GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA];
                     GO_process: GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HIN4237219.1"
                     /translation="METYYKAINWNAIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDW
                     RKLSNKEKDLVGKVFGGLTLLDTMQSETGVQALRADIRTPHEEAVFNNIQFMESVHAK
                     SYSSIFSTLNTKAEIEEIFEWTNTNPYLQKKAEIVNEIYLNGSPLEKKVASVFLETFL
                     FYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELPEEEQEKLK
                     EWMYDLLYTLYENEEGYTESLYDGVGWTEEVKTFLRYNANKALMNMGQDPLFPDSAED
                     VNPIVMNGISTGTSNHDFFSQVGNGYLLGEVEAMQDDDYNYGLD"
     gene            complement(12005..14164)
                     /gene="nrdE"
                     /locus_tag="AC0DU4_001260"
     CDS             complement(12005..14164)
                     /gene="nrdE"
                     /locus_tag="AC0DU4_001260"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000523276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HIN4237220.1"
                     /translation="MGLKHLEDVTYFRLNNEINRPVNGQIMLHKDKEALDAFFKENVV
                     PNTMVFDSIKDKINYLIEHNYIETAFIKKYRPEFLEELAQFIKDQNFQFKSFMAAYKF
                     YNQYALKTNDGEYYLENMEDRVFFNALYFADGNEAVAIDIANEIIHQRYQPATPSFLN
                     AGRARRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGY
                     EGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVR
                     VKTLSLGVVVPDKFYELARKNEEMYLFSPYSVEKEYGVPFNYIDITEKYDELVANPNI
                     RKTKIKARDLETEISKLQQESGYPYVVNIDTANRANPVDGKIIMSNLCSEILQVQEPS
                     LINDAQEFLQMGTDVSCNLGSTNVVNMMTSPDFGRSIRAMVRALTFVTDSSHIVAVPT
                     IDHGNSQAHTFGLGAMGLHSYLAQQLIEYGSPESVEFTSIYFMLMNYWTLVESNNIAR
                     ERGITFHNFEKSDYANGSYFDKYVTGEFVPTSDRVKELFKNVFIPGVADWAELRDKVQ
                     EDGLYHQNRLAVAPNGSISYINDVSASIHPITQRIEERQEKKIGKIYYPAAGLSTETI
                     PYYTSAYDMDMRKVIDVYAAATEHVDQGLSLTLFMRSDIPKGLYEWKRENKQTTRDLS
                     ILRNYAFNKGIKSIYYVRTFTDDGGEVGANQCESCVI"
     gene            complement(14245..14463)
                     /gene="nrdH"
                     /locus_tag="AC0DU4_001261"
     CDS             complement(14245..14463)
                     /gene="nrdH"
                     /locus_tag="AC0DU4_001261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000259243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutaredoxin-like protein NrdH"
                     /protein_id="HIN4237221.1"
                     /translation="MVTVYSKNNCVQCKMTKRFLDSNNVSYREINLDEQPEYVDQVKE
                     LGFSAAPVIQTPTEVFSGFQPGKLKQLA"
     gene            14814..15077
                     /locus_tag="AC0DU4_001262"
     CDS             14814..15077
                     /locus_tag="AC0DU4_001262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019775469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphocarrier protein HPr"
                     /protein_id="HIN4237222.1"
                     /translation="MASKDFHVVAETGIHARPATLLVQTASKFASDITLEYKGKSVNL
                     KSIMGVMSLGVGQGADVTISAEGADADDAIAAISETMEKEGLA"
     gene            15083..16816
                     /gene="ptsP"
                     /locus_tag="AC0DU4_001263"
     CDS             15083..16816
                     /gene="ptsP"
                     /locus_tag="AC0DU4_001263"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008965 - phosphoenolpyruvate-protein
                     phosphotransferase activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HIN4237223.1"
                     /translation="MTEMLKGIAASDGVAVAKAYLLVQPDLSFETITVEDTNAEEARL
                     DAALQASQDELSVIREKAVGTLGEEAAQVFDAHLMVLADPEMISQIKETIRAKKVNAE
                     AGLKEVTDMFITIFEGMEDNPYMQERAADIRDVTKRVLANLLGKKLPNPASINEEVIV
                     IAHDLTPSDTAQLDKNFVKAFVTNIGGRTSHSAIMARTLEIAAVLGTNNITEIVKDGD
                     ILAVNGITGEVIINPTDEQAAEFKAAGEAYAKQKAEWALLKDAQTVTADGKHFELAAN
                     IGTPKDVEGVNNNGAEAVGLYRTEFLYMDSQDFPTEDEQYEAYKAVLEGMNGKPVVVR
                     TMDIGGDKELPYFDMPHEMNPFLGFRALRISISETGDAMFRTQIRALLRASVHGQLRI
                     MFPMVALLKEFRAAKAVFDEEKANLLAEGVAVADNIQVGIMIEIPAAAMLADQFAKEV
                     DFFSIGTNDLIQYTMAADRMNEQVSYLYQPYNPSILRLINNVIKAAHAEGKWAGMCGE
                     MAGDQQAVPLLVGMGLDEFSMSATSVLRTRSLMKKLDTAKMEEYANRALTECSTMEEV
                     LELQKEYVNFD"
     gene            17070..>18181
                     /locus_tag="AC0DU4_001264"
     CDS             17070..>18181
                     /locus_tag="AC0DU4_001264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HIN4237224.1"
                     /translation="MKINKKYLVGSAAALILSVCSYELGLYQARTVKENNRVSYIDGK
                     QATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISEE
                     LLMKDPNYQLKDEDIISEIKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHS
                     QHREGGTSANDGAVAFARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKN
                     ELSASELAAAEAFLSGRENLSNLRTYRRQNSDNTPRTNWVPSVSNPGTTNTNTSNNSN
                     TNSQASQSNDIDSLLKQLYKLPLSQRHVESDGLIFDPAQITSRTARGVAVPHGNHYHF
                     IPYEQMSELEERIARIIPLRYRSNHWVPDSRPEEPSP"
BASE COUNT         5686 a         3260 c         3769 g         5466 t
ORIGIN      
        1 caggaagtct aataaagaaa ctagcaaggt caggccttac tttattggtg gacatccagg
       61 atttaattgt cctctacttg atgatgaagt ctatgaagat tattatctag agtttgagaa
      121 agaagagact tgctctgttc cacgtccttt cccagaaaca ggtatgttgg atttccaaga
      181 tagaagtcca tggctagagg gacaaaaaga aatagatctt agttatgatc ttttcagcac
      241 agatgcagtg actttggatg aattgcaatc tcgaacaatt gcccttcgtt ctcttaaaca
      301 tgataaggga ttgaaagtgc attttgcaga atttccaaac ctcatcatct ggtcaacttt
      361 gaacaaggga cctttcatta cctttgaacc atggtctggc ttgtcaacat cccttgaaga
      421 aggagatcat ttagaagata agaagaatgt ttgtctctta gaagccaatc aggttgaaga
      481 attagggttt gagatagaag ttttataaaa aagtaaaaaa taaataacaa aaacaaacac
      541 aaactattga cttcttcaaa caatagtagt atattatgtt tgtgaggact aattgactgt
      601 tttttaaaga tagccaatac actgctggaa tccagcatag aaaaaataaa aaggagtata
      661 caatatgtct attgttatcg gtgcagatgc tgcaggtttg agattgaaag aagttgtgaa
      721 agacttctta gaaaaagaaa acttccacct tgtggatgtt acagctgaag gtcaagactt
      781 tgttgatgtg actctcgctg ttgctgcaga agtaaacaaa gaagaacaaa accttggtat
      841 cgtgattgat gcttatggag ctggtccatt tatggttgca actaagatca aaggaatggt
      901 tgctgcagaa gtatctgacg aacgttcagc ttatatgact cgtggccaca acaactcacg
      961 tatgatcact atgggggcac aacttgttgg tgatgaattg gctaaaaaca tcgctaaagg
     1021 atttgttaat ggtaaatacg acggtggtcg tcaccaaatc cgggttgaca tgttgaacaa
     1081 aatgggctaa ttagattata gtaagaaagg taagttaaaa atgagaattg caattggatg
     1141 tgaccacatc gtaactgatg aaaaaatggc ggtttcagaa tttttgaaat caaaaggata
     1201 tgaagtcatt gactttggta catatgacca tacacggact cactacccaa tctttggtaa
     1261 aaaagtaggg gaagcagtaa ctagtggtca agctgatctc ggggtatgta tctgtggtac
     1321 tggtgttggt atcaacaacg ctgtaaataa agttccaggt gttcgttctg ccttggttcg
     1381 tgatatgaca acagcccttt atgctaaaga acaattgaac gctaacgtta tcggctttgg
     1441 tggtaagatt actggtgaat tgcttatgtg tgatatcatc gaagctttca ttcatgctga
     1501 atacaaacca tctgaagaaa acaagaaatt gattgcgaaa attgaacacc ttgaaagtca
     1561 caatgctcaa caaacagacg caaacttctt tacagaattc cttgaaaaat gggatcgcgg
     1621 agaataccac gactaagagg tgacctatga ttttaacagt cacaatgaac ccatccattg
     1681 atatttccta tcccttggat gagttgaaga ttgatactgt caatcgtgtg gtggatgtaa
     1741 ccaaaacggc tggtggtaag ggacttaatg ttacccgagt actttcagaa tttggcgatt
     1801 ctgttcttgc tactggttta gtgggtggca aacttggtga gtttttggtt gaacatatcg
     1861 ataatcaagt aaagaaagat ttcttctcaa ttcagggaga aactcgtaac tgtatcgcta
     1921 ttctccacgg agacaaccaa acagaagttc ttgaaaaagg tcctgaagta ttggaacagg
     1981 aaggtcaaga ctttttggaa catttcaaaa aactcttgga gtcagttgaa gtagtggcca
     2041 tctcaggtag tctgccagct ggccttccag ttgattacta tgcgagcttg gtagaacttg
     2101 ctaatcaagc tggcaagcct gtagtcttgg actgctcagg tgcagcactt caggctgttc
     2161 ttgaatcacc ccataaacca acagtcatca aaccaaataa tgaagaattg tctcagcttc
     2221 ttggaagaga agtttctgag gatttggatg aattaaaaga agtacttcaa gaacctttgt
     2281 ttgcagggat tgaatggatt atcgtttcac ttggtgccaa cggtactttt gccaaacatg
     2341 gtgacacttt ctacaaggta gatattccta gaattcaggt ggtaaatcct gttggatctg
     2401 gagactctac tgtggcagga atttcttcag gacttcttca caaagaatcg gatgcagaat
     2461 tactcatcaa ggcaaatgtc cttggtatgc tcaatgctca agaaaaaatg actggtcatg
     2521 tcaacatggc caactatcaa gctctatatg atcaattaat agtaaaagag gtataaaatg
     2581 gctttaacag aacaaaaacg tgtacgctta gaaaaacttt ctgatgaaaa tggtatcatc
     2641 tcagctcttg catttgacca acgtggtgct ttgaaacgcc tcatggctca acaccaaaca
     2701 gaagaaccaa ctgtggccca aatggaagaa cttaaagtct tggtagcaga tgaattgact
     2761 aaatacgctt catctatgct tcttgaccct gagtatggac ttccagcaac taaagctctt
     2821 gatgaaaaag ctggtcttct ccttgcttat gaaaaaacag gttatgacac aacaagcaca
     2881 aaacgcttgc cagactgctt ggatgtttgg tctgcaaaac gtattaaaga agaaggtgca
     2941 gatgcagtta aattcttgct ttactatgat gtagatagct cagacgaact caatcaagaa
     3001 aaacaagcct acatcgaacg catcggttct gagtgtgtgg ctgaagatat cccattcttc
     3061 cttgaaatcc ttgcttacga tgaaaaaatt gcggatgcag gttctgtaga atacgctaaa
     3121 gtaaaaccac acaaagttat cggcgctatg aaagtctttt cagacccacg ctttaacatt
     3181 gatgttttga aagttgaagt tcctgttaac attaaatatg ttgaaggctt cgctgaaggt
     3241 gaagtagttt atacacgtga agaagcagca gccttcttca aagcgcaaga tgaagcaacg
     3301 aacttgccat acatctactt gagtgctggt gtatcagcta aactcttcca agatactctt
     3361 gtatttgctc atgaatcagg tgcaaacttt aacggagttc tttgtggccg tgctacatgg
     3421 gcaggatcag ttgaagctta catcaaagat ggtgaagcag cagctcgcga atggcttcgc
     3481 acaactggat ttgaaaacat tgacgaactc aacaaagttc ttcaaagaac agcaacttca
     3541 tggaaagaac gcgtgtaaga aagtcctcct agtttaggaa catgaatcta aaaaaattta
     3601 aaaaaagttg tatgtaaagg tttacaaaat aacttacttg tgctatactt aaatcacaag
     3661 ttaatatgaa ttagaaagta actatatgaa gtataataaa aataggatat agtttatttt
     3721 acgagctagg aaggaaaaat acggaaacaa tattgccaga ataaactata tttagatgca
     3781 catttcattc attgttttat aaaaggagaa gataaacggc tactaaaaag agttttaaag
     3841 cgttagttgt aggactaggt attgtttcaa tattctcatc agccttacct atggttagtg
     3901 gttctgtatt tgcagatagt gccctaacta cagtatacag tagataaagc aaatgatatt
     3961 gttttgaatg ttgatgggaa taaattttat aatgtttcgg tttcagaaga tattgtaaat
     4021 gctggtcaaa ttttggaaga ttatttttat gtagataaat ttggaaatat aaatttaaaa
     4081 ggcactcctg aagagttagc aaaaaatatt ggtatttctg tacaagaagc aagtttgatg
     4141 tatgaagctg taaaagagtt acccaacgtt tacgaaagag gtcctgtagg ttttcgtttc
     4201 aatcttggtc ctcaagtgag ggggatgggt ggctgggctg ctggagcttt cgctactgga
     4261 tatgctggat ggcatttgaa acaatttgcg gttaatcctg ttacatctgg atttgttgct
     4321 gtaataagtg gtgcgattgg ctgggctgta aaaactgctg tagaaaatta ttggacagtt
     4381 gctgtagcta cagtagaagt gccgtttgtg aaccttgttt acaccataga tttaccttag
     4441 aggttatttc tttatgaatc attcttttaa aaaaataact gtattttgtt ttatagtttc
     4501 ttgtgttctt tgtttattag acttaatgaa ttttaaaaat gtagctactt ttttattttt
     4561 ctgtcttcct gtttttgttt tgatttacaa aaataaataa aaacagagcc tctgtttgat
     4621 gaattttaga acatagttaa gttttaaaaa aagttgtatg taaaggttta caaaacaacc
     4681 gacttgtgct atacttaaat cacaagttaa tacaaggtga gtgttactaa gtaatattag
     4741 gcatgatcac aggtgaatta gaaatcagct gattttctag ttcatttgtg gtcatttttt
     4801 gtactcatat acctttaaga tataaaagga ggttgacatg tatcgaattc taaatccaat
     4861 gaatcacaat gtctcgcttg tcagaaatga taagggagaa gaggtgatta taattggtaa
     4921 ggggattgca ttcggaaaaa ggaaggggga tttgattgct gaaaatcagg ttgagaaaat
     4981 ctttcggatg aagaccgaag agtccagaga aaactttatg gctcttctca aagatgttcc
     5041 gcttgatttt atcacagtga cctatgaaat cattgataag ctatcaaaga aatatcatta
     5101 tccgattcaa gagtatctct atgtaacctt gacagatcat atttactgtt cttatcaagc
     5161 tctaactcaa ggaaggtaca aggatagtaa tctgccggat atttccgcta agtatcctgt
     5221 cgcttttcaa atcgcaaatg aagcttttga aatttaccgt cagaagctag cagatcattt
     5281 tcctgaggac gagattattc ggattgctta tcatttcatc aatgccgaag gtgaaaatga
     5341 agtggaactt gtggagtcga ttgataagag gaaagaaatt ctcaggaatg ttgaagaagt
     5401 gctaaagggt tatgcaattc aacgaaccaa aaaaaataat catttctatg atcgctttat
     5461 gattcatttg aattatttct tggattattt agacagatct agagatgata accaatcact
     5521 tctggatatg gaagatcata ttaaacaatc ctatccaaaa gccttcgaga ttggttccaa
     5581 gatctatgat gtgattacgc aacatacggg tcttgatttg tataaaagtg aacgagttta
     5641 tctagttcta catatccaac gtttattgtc ataaaaattt atttaaaact atataaggag
     5701 aattctatca tgaatagaga agaagtaaca ttgttaggtt ttgaaatcgt agcctatgct
     5761 ggcgatgctc gttcaaaact attggaagcc ttgaaggctg ctgaagctgg tgattttgaa
     5821 aaagcggacg ctctggtaga ggaagctggt agctgtattg cagaggctca ccacgcgcaa
     5881 acaagtctat tgactaagga agcttctggt gaggacttag cgtatagtgt gaccatgatg
     5941 catggccaag accacttgat gacaactatc ttgttaaagg atttgatgca ccatttgatc
     6001 gaactctata agagaggagt taaataatga acaaactaat tgcatttatc gagaaaggaa
     6061 agcctttctt tgagaaacta tctcgtaata tctatcttcg tgctattcgt gatggtttca
     6121 ttgcaggtat gcctgttatt ctcttctcaa gtatctttat cttgattgcc tttgtaccaa
     6181 actcatgggg ctttaaatgg tctgatgaag ttgtagcctt tctgatgaaa ccttatagct
     6241 attctatggg tattctggct ctcttggtag ctggtacaac agctaagtca ttgactgact
     6301 cagtaaaccg gagcatggaa aaaaccaatc aaatcaacta tatgtcaacg ctgttagcag
     6361 cgattgttgg tttgttgatg ttggcagctg atcctatcga aagtggtcta gctactggat
     6421 tcttggggac aaaaggtttg ctttcagcct tccttgctgc cttcgttact gtagccatct
     6481 ataaggtttg tgttaagaac aacgtcacta ttcgtatgcc tgacgaagtt ccaccaaata
     6541 tctcacaagt ctttaaagat gtgattccat tcactctatc agtggtttct ctttatgctc
     6601 ttgatttact agctcgtcat tttgttggtt ctagtgtggc agaatcaatc ggtaaattct
     6661 tcgcaccact cttctcagca gcagacggat accttggtat taccattatc tttggtgcct
     6721 ttgccttctt ctggtttgtg ggtattcatg gtccatctat tgttgaacct gctatcgcag
     6781 cgattaccta tgcaaatgct gaagtcaact tgaaccttct ccaacaaggt atgcatgctg
     6841 ataaaatcct tacttcagga actcaaatgt ttatcgttac tatgggaggt actggtgcga
     6901 cactggttgt tccattcatg ttcatgtggt taacaaaatc aaaacgtaac cgtgcaatcg
     6961 gacgtgcttc agtagttcca actttctttg gtgtaaatga accaatcttg tttggtgcac
     7021 cacttgtatt aaatccaatc ttcttcattc catttatctt tgctccaatc gcaaacgtat
     7081 ggattttcaa attctttatt gaaactcttg gaatgaactc attcactgct aatctaccat
     7141 ggacaactcc agctccacta ggtctagttc ttggaactaa cttccaagtg ctatcattca
     7201 ttcttgctgc ccttctaatc gtggttgacg ttgtcattta ctatccattc cttaaggtct
     7261 atgatgaaca aattcttgaa gaagaacgtt caggtaagtc taatgatgaa ttgaaagaaa
     7321 aagttgctgc aaacttcaac actgcaaaag cggatgctat tcttgaaaaa gcgggtgtag
     7381 aagcagcaca aaatacaatc actaaagaaa caaatgtcct cgttctctgt gcaggtggag
     7441 gaacaagtgg tctccttgca aatgctttga ataaggcagc agcagaatac aatgtccctg
     7501 tgaaagcagc agcaggcggc tatggtgctc accgtgaaat gttaccagag tttgatcttg
     7561 ttatccttgc ccctcaagtt gcttcaaact ttgaagatat gaaggcagaa acagataagc
     7621 tcggtattaa actagcgaaa acagaaggcg ctcaatacat caaattaact cgtgatggaa
     7681 aaggtgctct tgcattcgta caagcgcaat tcgattaagg ctagagactc tgaaatagtc
     7741 tcctatcgtt acggaaatcg ctatggcgaa tttcctatta ttaattcgtc ggtaaaaaga
     7801 tatcgttttt acctcctcat gtcacaattc ggtgacttgg tacaagaagt gagatggaga
     7861 aggatggctc actgactcct ctcctctcac ttttacttta tttaaatcaa gaaataggtg
     7921 aaaaaaatga caaaaacact tccaaaagac tttatttttg gtggcgcaac agctgcctat
     7981 caagcagaag gtgctacaca tactgatggt aaaggaccag tagcgtggga taaatatctt
     8041 gaagataact actggtacac tgcagaacca gccagtgatt tttacaatcg atatccagtt
     8101 gacctcaagc tagcagaaga gtatggtgtc aatggtattc gaatttctat tgcttggtca
     8161 cgtattttcc cgactgatta cggccaagta aatgctaaag gtgttgagtt ttatcataat
     8221 ttatttgcag agtgtcacaa acgtcatgtt gagccttttg taactcttca tcactttgac
     8281 acgccagaag ctctccactc aaatggagac ttcttaaacc gtgaaaatat cgaacatttt
     8341 gtagactacg ctgccttctg ttttgaagaa tttccagaag taaactattg gacaaccttt
     8401 aatgaaattg gaccaatcgg tgatggtcaa tatttggttg ggaaattccc tccaggtatc
     8461 cagtacgacc ttgccaaagt ctttcaatca caccacaata tgatggtgtc tcatgcacgc
     8521 gcggtaaaat tgtacaaaga gaaaggctat aaaggggaaa ttggtgttgt tcacgccctg
     8581 ccaactaaat atcctctaga tcctgaaaat ccagcagatg ttcgtgcagc tgagttggaa
     8641 gatatcatcc acaataaatt catcttagac gcaacttatc taggtcgcta ttcagctgaa
     8701 accatggaag gtgtcaacca tatcttatca gtcaatggtg gtagcttgga tcttcgtgaa
     8761 gaagatttta cagcattaga agctgcaaaa gacttgaatg atttcctagg aatcaactac
     8821 tatatgagtg actggatgga agcctttgat ggagaaactg aaattatcca taatggtaaa
     8881 ggtgaaaaag gaagctctaa gtatcaaatc aaaggtgttg gtcgtcgtgt agctcctgac
     8941 tatgtaccac gcacggattg ggattggatt atctaccctc aaggtttgta tgaccaaatc
     9001 atgcgtgtga agaaagatta tcctaactac aagaagattt acatcactga aaatggtctc
     9061 ggctataaag atgagttcgt tgataacact gtttacgatg atggtcgtat tgattacgtg
     9121 aaacaacact tggagatctt gtctgatgcg attgcagatg gagctaatgt aaaaggttac
     9181 ttcatttggt cattaatgga tgtcttctca tggtcaaacg gttatgagaa acgttatggt
     9241 ctcttctacg tagattttga aactcaagaa cgttatccta agaaatcagc tcactggtac
     9301 aagaaagtag cggaaactca gattatagac tagtagaatt agtcattaga tatagaattt
     9361 tagtgagtca aaaagatgtt caaagatttt atccaatcta tttatgaaaa agtttatatt
     9421 ataaatttcg aaaaatgctc tcaaataccg tgtttgacga gtgaagaatt gaaaagtctt
     9481 ggaaaatggt atgtctcgac tggtaaagaa tggatttgtc attcagatga tgagctggaa
     9541 gaatttaaaa atctattttt aaattttatc aatcctgaag gatgggatac tatctccttt
     9601 gattcagatt ttatgccgtt tcaacaatcg taaccaattt ctcaaaaaag ttaaatctta
     9661 tatttagtac tctgtaaaac tcttatctaa tcacgttgct tatactcaat gaaaatcaaa
     9721 gagcaacttt aaactaggaa gcgagtcgca gatttctcaa tgcatagctt tgaggaattg
     9781 ggcaaaaagt ctttgatata gaaaaacgca tagtatcagg tgttgaaaca cctgatacta
     9841 tgcgttttat tgtgggaaga tttacttttt ttcttctgaa attgagttgt tacccaggct
     9901 ctttcagttt attaaggctt gatgacttta atgtgtttag atagcttaaa aaggattgaa
     9961 tcacttagtt tagaatctga aacaatagta tcaagatttg atacattata aaaagtataa
    10021 aaatcaaact tattgaactt gctatgatct gcgagtaaat attttttatt agaattattt
    10081 aaagcgatgc gttgagcctc tccctcttcc tcgctaaaag tagctagagc tccgttttga
    10141 ataccattac agctaacgaa agctttagaa aattggagat tagagagatt ttgtagggtc
    10201 aatgtaccaa caaaagcacc tgtaatatcg cgataatttc cacctattaa aatcaaatct
    10261 gttaattttc gttcgcttaa aatcagaaaa acaggtagac tgttggttac gacgcggata
    10321 ttgtcaatag gcaactcacg cgcaaaaaac tctaatgttg ttcctggtcc aatgaaaata
    10381 gtttctcttt cttctactag actgcctgca aaatgggcta tttcttgttt ttctgccgtt
    10441 tggagggctt gtttttcaat atttgatcgc tcattagtca aaagggagtt ggttcgaagt
    10501 ttttcagctc caccatgcac acgaatcagc aaatctttat cagctaattc ctgtaaatag
    10561 cgccttgcag tcatatctga aacggctatt tcgtccataa tctgtttaac tgttatggtt
    10621 cctttactat ttactatctc taaaattttg gctaattttt cttgtttgag catattatca
    10681 cctcgtttcc tactactatc ttaccataaa caaactcatc attcaaatac aaaaacaaca
    10741 aaatgaaaca aaaacaaaaa tatcgaagtt tgttttcaaa actttcgata tttttgttgg
    10801 gttataactt tgatgtttct agtttacttt ttgatgattg agagtgatgg agaattagtc
    10861 taaaccgtag ttatagtcat cgtcttgcat ggcttcaact tcgccaagaa ggtaaccatt
    10921 tccgacttga gagaagaagt catggttgga agttcctgtt gaaataccgt tcataacgat
    10981 tgggttgaca tcttcagctg aatctgggaa aagtggatct tgtcccatgt tcatgagagc
    11041 tttattggca ttgtagcgaa ggaaggtttt aacctcttca gtccaaccaa caccgtcata
    11101 aagactctct gtgtagcctt cttcattttc ataaagagta tagagtaggt cgtacatcca
    11161 ttctttgagt ttttcttgct cttcttcagg caattcattg aaaccaagtt ggaatttgta
    11221 accaatgtag gttccgtgaa cagactcgtc acgaataatc aatttaatga tttctgcaac
    11281 gttggcaagt ttgttgttac cgagatagta gaggggagtg aagaaaccag agtagaagag
    11341 gaaggtttcg aggaagacgc tggcaacttt cttttcaagt gggctgccgt ttaggtagat
    11401 ttcgttgaca atctcagcct tcttttgtag gtaaggattg gtattggtcc attcgaaaat
    11461 ttcttcaatc tcagccttag tattcaaggt agaaaagatt gatgagtaag atttagcgtg
    11521 gacagattcc ataaattgga tgttattgaa aacagcttcc tcatgtggtg tacggatgtc
    11581 tgcgcgaagg gcttgaaccc cagtttcaga ttgcatagtg tcaagaaggg ttaaaccacc
    11641 aaaaactttt ccgaccaagt ctttctcttt gttagatagc tttctccagt catccaagtc
    11701 gtttgataag ggaatacgtg tatcgagcca aaattgctcc gtcagttttt cccaagttga
    11761 tttgtcgatg acatcttcga tggcattcca gttaatggct ttgtagtaag tttccattta
    11821 aaatctcttt ctgtgtttag tattgcgaac tcacaattat ttctacttta ccataattct
    11881 ataggagtat cgcacaaaaa gtcggaagcc cgacttttaa aatgttacat aaattatgtt
    11941 atgacatagt agatttgatt ttatcagtgc tgcttaggga aaaatagtgt ttctatgcta
    12001 gaaactaaat cacacagctt tcacattggt tggcgccgac ttctccaccg tcatctgtaa
    12061 aggtacggac gtagtagata gacttgattc ccttgttaaa ggcatagtta cgaaggatgg
    12121 acaaatcacg tgtcgtttgt ttattttccc tcttccattc gtaaaggcct tttggaatgt
    12181 cactacgcat gaagagggtg agtgaaagtc cttgatccac gtgttcagtc gcagcagcgt
    12241 aaacatcgat gactttacgc atatccatat cgtaggcaga agtgtagtaa ggaatggttt
    12301 ctgtagacaa gccagcagca gggtagtaga ttttaccaat tttcttctct tggcgttctt
    12361 cgatacgttg cgtaatcggg tggatagaag cagaaacgtc gttgatatag ctgatagaac
    12421 catttggcgc tacagcaagg cgattttggt ggtaaagacc atcttcttga accttgtcgc
    12481 gaagttcagc ccaatcagca acaccaggga taaagacatt tttgaagagt tctttaacac
    12541 ggtctgatgt tggaacaaat tcaccagtta catacttgtc aaagtaactt ccgttagcat
    12601 agtctgattt ttcaaagttg tggaaggtaa taccacgttc acgcgcaata ttgtttgact
    12661 ctaccaaggt ccagtagttc ataagcataa agtagatgct tgtaaattca acagactcag
    12721 gtgaaccata ttcaatgagt tgttgggcaa ggtagctgtg cagtcccatg gcaccgagac
    12781 caaaggtgtg ggcttggcta tttccatggt caatcgttgg tacagctacg atatgtgaac
    12841 tatctgtaac gaaagtaagg gcacgaacca tagcacggat agaacgacca aaatcaggtg
    12901 aagtcatcat gttaaccacg ttggttgaac ccaggttaca tgaaacatct gttcccattt
    12961 gaaggaattc ttgagcatcg ttgatcaagc ttggttcttg aacttgaaga atctcagaac
    13021 acaagttact catgataatc tttccatcaa caggatttgc acggttagcc gtatcgatgt
    13081 tgactacata aggatagcca gactcttgtt gcaatttaga gatttcagtt tccaaatccc
    13141 gcgccttgat ttttgtcttg cgaatatttg gatttgcgac caattcatcg tatttttcag
    13201 taatgtcgat gtaattgaat ggcacaccgt attctttttc tacagagtaa gggctgaaga
    13261 ggtacatttc ttcattttta cgagccaatt cgtagaattt atcaggtact acaacaccaa
    13321 gtgatagagt cttgacacgt actttttcat cagcgttttc tttcttagtt gaaaggaaag
    13381 cgatgatatc tgggtgaaag acgttgaggt agacaacacc ggcaccttga cgttgcccca
    13441 attggttgga gtaagagaag ctgtcttcaa aaagcttcat aacaggaacg acacctgaag
    13501 cagctccttc atagcctttg ataggtgcac cagcttcacg aaggttgctg agggtaattc
    13561 ccacaccacc accaatacgt gaaagttgaa gagctgagtt gatagaacgt ccgatagagt
    13621 tcatatcatc cgtcacttgg attaggaaac aagataccaa ctccccacgg cgagcacgtc
    13681 cagcattcaa gaaggaagga gtagcaggtt ggtagcgttg gtggatgatt tcattggcaa
    13741 tatcgattgc aacagcttca ttcccatcag cgaaataaag ggcgttgaag aagacacggt
    13801 cttccatatt ttcaagatag tattcaccgt cattagtctt taaggcatat tgattgtaaa
    13861 atttataagc tgccatgaat gacttgaatt ggaagttttg gtctttgata aattgagcca
    13921 attcttccaa gaactctgga cggtatttct tgataaaggc tgtttcgatg tagttgtgtt
    13981 caatgaggta attgattttg tctttgattg aatcaaaaac catagtgttt ggaactacat
    14041 tttctttaaa gaaagcatcc aaggcttcct tgtctttatg aagcatgatt tgtccattaa
    14101 caggacggtt aatttcgtta ttaagacgga agtaagtcac gtcttcaaga tgttttaatc
    14161 ccataaaatt tcccttatct aattacaaaa gaaaggcttc taagttagcc ctaaaagcag
    14221 ttttttctgg atgatgtact aagattatgc taattgcttc agttttcctg gttggaaacc
    14281 tgaaaagact tcagttggtg tttggataac aggagctgcg ctaaaaccga gctctttaac
    14341 ttgatcgacg tactcaggtt gctcatcaag attgatttca cgataagaga cattattact
    14401 gtccaagaaa cgcttggtca ttttacattg gacacaattg tttttagaat aaacggttac
    14461 cattgtgtaa ctcctcttca aaatttaata ctatcttagt atatcagaaa ataaaatttt
    14521 gtcaatgatt tgaactaaat atagtggtgt tcttttgttg tttttatata taaacacaat
    14581 atatagtgtt tgtgttgtga aatagcaatg attatcctat aaattgtttt tgaagaaact
    14641 atatcctgtg ttttgttatc taggatagaa gattttcagc aagttatctg aaaggaaatt
    14701 gaaggaaaat ccagaaaatg cttgaaaaaa atcctagaag atggtataat actaaattgt
    14761 aagggttatc acatataact caaaaaaaga aagaacaaaa ggagagtcaa actatggctt
    14821 ctaaagattt ccacgtagtg gcagaaacag gtattcacgc acgtccagca acattgttgg
    14881 tacaaactgc tagcaaattt gcttcagata tcactcttga gtacaaaggt aaatcagtta
    14941 accttaaatc aattatgggt gttatgagtc ttggtgttgg ccaaggtgct gacgtaacta
    15001 tctcagctga aggtgcagat gcagatgacg ctatcgctgc aatctcagaa acaatggaaa
    15061 aagaaggatt ggcataaggg aaatgacaga aatgcttaaa ggaatcgcag catctgacgg
    15121 tgttgcagtt gcaaaagcat atctactcgt tcagccggat ttgtcatttg agactattac
    15181 agtcgaagat acaaacgcag aagaagctcg ccttgatgcc gctctacagg catcacaaga
    15241 cgagctttct gttattcgcg agaaagcagt aggtacgctc ggtgaagaag cagctcaagt
    15301 ttttgatgct cacttaatgg ttcttgctga cccagaaatg atcagccaaa tcaaggaaac
    15361 tatccgtgcg aagaaagtga atgcagaagc aggtctgaaa gaagttacag atatgtttat
    15421 cactatcttt gaaggcatgg aagacaaccc atacatgcaa gaacgcgcag cggatatccg
    15481 cgacgtgaca aaacgtgtat tggcaaacct tcttggtaaa aaattgccaa acccagcttc
    15541 tatcaatgaa gaagtgattg tgattgcgca tgacttgact ccttcagata cagctcaatt
    15601 ggacaaaaac tttgtaaaag cttttgtaac caacattggt ggacgtacaa gccactcagc
    15661 tatcatggca cgtacacttg aaattgctgc tgtattaggt acaaacaaca tcactgaaat
    15721 cgttaaagac ggtgacatcc ttgctgttaa cgggatcact ggagaagtga ttatcaaccc
    15781 aacagatgaa caagcggcag aatttaaagc agctggtgaa gcctatgcga aacaaaaagc
    15841 tgaatgggca cttttgaaag atgctcaaac agtgactgct gacggtaaac acttcgagtt
    15901 ggctgccaat attggtactc caaaagacgt tgaaggtgtt aacaacaacg gtgcagaagc
    15961 tgttggactt taccgtacag agttcttgta catggattct caagacttcc caactgaaga
    16021 tgagcagtat gaagcataca aggctgttct tgaaggaatg aacggtaaac ctgttgtcgt
    16081 tcgtacaatg gatatcggtg gagataagga acttccttac ttcgatatgc ctcacgaaat
    16141 gaacccattc cttggattcc gtgctcttcg tatctctatc tctgagactg gagatgctat
    16201 gttccgcaca caaatccgtg ctcttcttcg tgcgtctgtt cacggtcaat tgcgtatcat
    16261 gttcccaatg gttgcgctct tgaaagaatt ccgtgcagcg aaagcagtct ttgatgaaga
    16321 aaaagcaaac cttcttgctg aaggtgttgc agttgcggat aacatccaag ttggtatcat
    16381 gatcgagatt cctgcagcag ctatgcttgc agaccaattt gctaaagaag ttgacttctt
    16441 ctcaattggt acaaacgact tgatccaata tacaatggca gcagaccgta tgaacgaaca
    16501 agtttcatac ctttaccaac catacaaccc atcaatccta cgcttgatta acaatgtgat
    16561 caaagcagct cacgctgaag gtaaatgggc tggtatgtgt ggtgagatgg ctggtgacca
    16621 acaagctgtt ccacttcttg tcggaatggg cttggatgag ttctctatgt cagcaacatc
    16681 tgtacttcgt acacgcagct tgatgaagaa actcgacaca gctaagatgg aagagtacgc
    16741 aaaccgtgcc cttacagaat gctcaacaat ggaagaagtt cttgaacttc aaaaagaata
    16801 cgttaatttt gattaatcga aaaatccctg caactcagtt acagggattt ttttgatatt
    16861 ttaaaaagaa ttttcaagaa aatctttctt atagaaagtc caaccttgaa aaagtagtgg
    16921 tcagaacaaa aaatacttaa atggttcata aaattcttga caagttggag atttaggagt
    16981 aaactattaa ccagttaagt aatagagagg agtttctgca atttagaaat gaattgcaac
    17041 tagaaatatc aaatagaaag agagtttcga tgaaaattaa taagaaatac cttgttggtt
    17101 ctgcggcagc tttgatttta agtgtttgtt cttacgagtt gggactgtat caagctagaa
    17161 cggttaagga aaataatcgt gtttcctata tagatggaaa acaagcgacg caaaaaacgg
    17221 agaatttgac tcctgatgag gttagcaagc gtgaaggaat caatgctgag caaatcgtca
    17281 tcaagataac agaccaaggc tatgtgactt cacatggcga ccactatcat tattacaatg
    17341 ggaaggttcc ttatgacgct atcatcagtg aagaattgct gatgaaggat ccaaactacc
    17401 agctaaaaga cgaggatatt atcagtgaaa tcaagggtgg ttatgttatc aaggtagatg
    17461 gaaaatacta tgtttacctt aaggatgctg cccacgcgga taatgtccgt acaaaagaag
    17521 aaatcaatcg gcaaaaacaa gaacatagtc agcatcgtga aggagggact tcagcaaacg
    17581 atggtgcggt agcctttgca cgttcacagg gacgctacac cacagatgat gggtatatct
    17641 tcaatgcatc tgatatcatt gaggacacgg gtgatgctta tatcgttcct cacggcgacc
    17701 attaccatta cattcctaag aatgagttat cagctagcga gttggctgct gcagaagcct
    17761 tcctatctgg tcgggaaaat ctgtcaaatt taagaaccta tcgccgacaa aatagcgata
    17821 acactccaag aacaaactgg gtaccttctg taagcaatcc aggaactaca aatactaaca
    17881 caagcaacaa cagcaacact aacagtcaag caagtcaaag taatgacatt gatagtctct
    17941 tgaaacagct ctacaaactg cctttgagtc aacgccatgt agaatctgat ggccttattt
    18001 tcgacccagc gcaaatcaca agtcgaaccg ccagaggtgt agctgtccct catggtaacc
    18061 attaccactt tatcccttat gaacaaatgt ctgaattgga agaacgaatt gctcgtatta
    18121 ttccccttcg ttatcgttca aaccattggg taccagattc aagaccagaa gaaccaagtc
    18181 c
//
LOCUS       DBMVGT010000033        17938 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.033, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000033 DBMVGT010000000
VERSION     DBMVGT010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 17938)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17938)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17938
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.033"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1339)
                     /locus_tag="AC0DU4_001265"
     CDS             complement(<1..1339)
                     /locus_tag="AC0DU4_001265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001063457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HIN4237225.1"
                     /translation="MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEF
                     AHYRTTGQLPGNAETDVQMSQQASGMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEI
                     QETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
                     EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNEVKVNAPSAENTFNILQGIRDLYQQ
                     HHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREI
                     ETEKDKQEKAVEAEDFEAALNYKTRIAELEKKIENHTEDMKVTASVNDVAESVERMTG
                     IPVSQMGASDIERLKDMAHRLQDKVIGQDKAVEVVARAIRRNRAGFDEGNRPIG"
     gene            complement(1902..2882)
                     /gene="mraY"
                     /locus_tag="AC0DU4_001266"
     CDS             complement(1902..2882)
                     /gene="mraY"
                     /locus_tag="AC0DU4_001266"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008963 -
                     phospho-N-acetylmuramoyl-pentapeptide-transferase activity
                     [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HIN4237226.1"
                     /translation="MFISISAGIVTFLLTLVGIPAFIQFYRKAQITGQQMHEDVKQHQ
                     AKAGTPTMGGLVFLITSVLVAFFFALFSSQFSNNVGMILFILVLYGLVGFLDDFLKVF
                     RKINEGLNPKQKLALQLLGGVIFYLFYERGGDILSVFGYPVHLGFFYIFFALFWLVGF
                     SNAVNLTDGVDGLASISVVISLFAYGVIAYVQGQMDILLVILAMIGGLLGFFIFNHKP
                     AKVFMGDVGSLALGGMLAAISMALHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKR
                     IFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLTLAILYLM"
     gene            complement(2884..5136)
                     /gene="pbp2X"
                     /locus_tag="AC0DU4_001267"
                     /gene_synonym="pbpX"
     CDS             complement(2884..5136)
                     /gene="pbp2X"
                     /locus_tag="AC0DU4_001267"
                     /gene_synonym="pbpX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2X"
                     /protein_id="HIN4237227.1"
                     /translation="MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNF
                     AVIIGTGTRFGTDLAKEAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDE
                     NYKSATGKILYVEKTQFNKVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITY
                     ANMMSIKKELEAAEVKGIDFTTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSG
                     MESSLNSILAGTDGIITYEKDRLGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQ
                     MDAFQEKVKGKYMTATLVSAKTGEILATTQRPTFDADTKEGITEDFVWRDILYQSNYE
                     PGSTMKVMMLAAAIDNNTFPGGEVFNSSELKIADATIRDWDVNEGLTGGRMMTFSQGF
                     AHSSNVGMTLLEQKMGDATWLDYLNRFKFGVPTRFGLTDEYAGQLPADNIVNIAQSSF
                     GQGISVTQTQMIRAFTAIANDGVMLEPKFISAIYDPNDQTARKSQKEIVGNPVSKDAA
                     SLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVPGQNVALKSGTAQIADEKNGGYLVGLT
                     DYIFSAVSMSPAENPDFILYVTVQQPEHYSGIQLGEFANPILERASAMKDSLNLQTTA
                     KALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQPIVVGTGTKIKNSSAEEGKNLAP
                     NQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEFQGSGSTVQKQDVRANTAIKD
                     IKKITLTLGD"
     gene            complement(5140..5457)
                     /gene="ftsL"
                     /locus_tag="AC0DU4_001268"
     CDS             complement(5140..5457)
                     /gene="ftsL"
                     /locus_tag="AC0DU4_001268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsL"
                     /protein_id="HIN4237228.1"
                     /translation="MAEKMEKTGQILQMQLKRFSRVEKAFYFSIAVTTLIVAISIIFM
                     QTKLLQVQNDLTKINAQIEEKKTELDDAKQEVNELLRAERLKEIANSHDLQLNNENIR
                     IAE"
     gene            complement(5469..6419)
                     /gene="rsmH"
                     /locus_tag="AC0DU4_001269"
     CDS             complement(5469..6419)
                     /gene="rsmH"
                     /locus_tag="AC0DU4_001269"
                     /EC_number="2.1.1.199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HIN4237229.1"
                     /translation="MTKEFHHVTVLLHETIDMLDVKPDGIYVDATLGGAGHSEYLLSK
                     LSEKGHLYAFDQDQNAIDNAQKRLAPYIEKGMVTFIKDNFRHLQARLREAGVQEIDGI
                     CYDLGVSSPQLDQRERGFSYKKDAPLDMRMNQDASLTAYEVVNNYDYHDLVRIFFKYG
                     EDKFSKQIARKIEQAREVKPIETTTELAEIIKLVKPAKELKKKGHPAKQIFQAIRIEV
                     NDELGAADESIQQAMDMLALDGRISVITFHSLEDRLTKQLFKEASTVEVPKGLPFIPD
                     DRKPKMELVSRKPILPSAEELEANNRSHSAKLRVVRKIHK"
     gene            6585..6779
                     /locus_tag="AC0DU4_001270"
     CDS             6585..6779
                     /locus_tag="AC0DU4_001270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HIN4237230.1"
                     /translation="MNRVKEFRKELGISQLELAKNIGVSRQTINMIENDKYNPTLELC
                     LNLARSLQTDLNSLFWEEDF"
     gene            6795..7037
                     /locus_tag="AC0DU4_001271"
     CDS             6795..7037
                     /locus_tag="AC0DU4_001271"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237231.1"
                     /translation="MKKEKKQLRYPGLKAGSIYGTVIFFIIPLIDTLTSENPNFISSL
                     LNTKHIFKTILGAFFFGVMIHIVDSLRIARAKKDQD"
     gene            7048..7383
                     /locus_tag="AC0DU4_001272"
     CDS             7048..7383
                     /locus_tag="AC0DU4_001272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000838135.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237232.1"
                     /translation="MKSLARLLIIHVFISIFLFFALISGAVSHTVLLLLLLFLPALNK
                     GLEKIQSKRIPVLNAALFFLLISFPQLLTNPVQWKFSIFLVVTIISSLAYFYNFYQVV
                     KEVDQKQLI"
     gene            complement(7493..8494)
                     /locus_tag="AC0DU4_001273"
     CDS             complement(7493..8494)
                     /locus_tag="AC0DU4_001273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HIN4237233.1"
                     /translation="MEKKLTIKDIAEMAQTSKTTVSFYLNGKYEKMSQETREKIEKVI
                     HETNYKPSIVARSLNSKRTKLIGVLIGDITNSFSNQIVKGIEDIASQNGYQVMIGNSN
                     YSQESEDRYIESMLLLGVDGFIIQPTSNFRKYSRIIDEKKKKMVFFDSQLYEHRTSWV
                     KTNNYDAVYDMTQSCIEKGYEHFLLITADTSRLSTRIERASGFVDALTDANMRHASLT
                     IEDKHTNLEQIKEFLQKEIDPDEKTLVFIPNCWALPLVFTVIKELNYNLPQVGLIGFD
                     NTEWTCFSSPSVSTLVQPSFEEGQQATKILIDQIEGRNQEERQQVLDCSVNWKESTF"
     gene            complement(8554..10455)
                     /locus_tag="AC0DU4_001274"
     CDS             complement(8554..10455)
                     /locus_tag="AC0DU4_001274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alginate lyase family protein"
                     /protein_id="HIN4237234.1"
                     /translation="MKEERRQFFERIDGNQCRDYILSHCSKDYEKVKSSLERLMDNRF
                     MFDSPWDMEPCSKIHQIQPMVWDQVFEDDPEWAYMLNRQEYLLQFMIGYLVEGDKSYI
                     QKCKFFLFDWIEQVREFSPQSLMTRTLDTGIRSFTWLKLLLLLLKFDLLEEKELEKIL
                     VSLEKQIDFMKSHYRAKYTLSNWGILQTIPMLAIYYFFSDKMDLEEAYHFASEELKQQ
                     IETQILGDGSQFEQSILYHVEVYKALLDLCLLLPDLQDSYRELLEKMATYIQMMTGLD
                     GRTLAFGDSDSTETTEILSLSAVVLNKEDLLNGLDVKVDLLSLLFLGREKVKRLQEFE
                     RRAWQPKSMIFEDSGHVCIKDEHRYLFFKNGPLGSAHSHSDENSFCLQYQGQPIFIDA
                     GRYSYREIYERYLLNSAWSHSTCIVDGKAPERITGSWEYEYYPHSLFCHHKEREGVHY
                     IEGAYWSAEPDLPYLHKRKILMLVEDVWLLVDDIRCQGQHEALTQFILDKDVTYQDGK
                     INQLRLWSEVDFDLEDTIISPKYNELERSSKLTKRQFFENQMLDYTIIAHESFEIIRH
                     SVYQTDDREVENALAFEVKNDETDKLILLLSEDIGVGEKLCLVDGTKMRGKCLVYDKI
                     NERMIRLQC"
     gene            complement(10477..10770)
                     /locus_tag="AC0DU4_001275"
     CDS             complement(10477..10770)
                     /locus_tag="AC0DU4_001275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000381741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_process: GO:0015031 - protein transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HIN4237235.1"
                     /translation="MDTTLFYGIVIVLAVSPLLLSSFHSIRQQKLLRKQMEQRQEYLA
                     SLTSGDEVLLLSGIHGKIISIKDDLVSLQIAKGVVIYVEKESVMGKTKELLFK"
     gene            complement(10770..11588)
                     /locus_tag="AC0DU4_001276"
     CDS             complement(10770..11588)
                     /locus_tag="AC0DU4_001276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HIN4237236.1"
                     /translation="MTGSNKLTKRDYLKTSLRAFFCQNGFNYSNYQGLGYANVMYPAL
                     KKHYGEDQEGFYQALEENCEFYNTNPHFLPFITSLHLVMLENGRPAKETRSIKMALMG
                     PLAGIGDSLSQFCLAPLFSTIAASFAQEGLVVGPILFFLAMNTILTAIKLSTGLYGYK
                     LGTTVIDKLSEQMATISRIANIIGVTVIAGLAATSVKIMVPITFAAGEVKADAKQSIV
                     SIQGMLDKVAPALLPALFTLLVYYLIKEKKWTTYKLVILTVIIGIIGSWLKIIA"
     gene            complement(11575..12354)
                     /locus_tag="AC0DU4_001277"
     CDS             complement(11575..12354)
                     /locus_tag="AC0DU4_001277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HIN4237237.1"
                     /translation="MSINVFQAILIGLWTAFCFSGMLLGIYTNRCIVLSFGVGIILGD
                     LPTALAMGAIGELAYMGFGVGAGGTVPPNPIGPGIFGTLMAITSAGKVSPEAALALST
                     PIAVAIQFLQTFAYTVRAGAPETAMKHLKNHNLKKFKFTLNATIWLFAFIGFTLGCLG
                     ALSMDTLLKLVDYIPPVLLTGLTVAGKMLPAIGFAMILSVMAKKELIPFVLLGYVCAA
                     YLNIPTIGIAIVGTIFALIEFYNKPKTADHVVEEEAHDDWI"
     gene            complement(12369..12860)
                     /locus_tag="AC0DU4_001278"
     CDS             complement(12369..12860)
                     /locus_tag="AC0DU4_001278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000178618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4237238.1"
                     /translation="MTMPNIIMTRIDERLIHGQGQLWVKYLGCNTVIVANDEVSTDKM
                     QQTLMKTVVPDSVAMRFFPLQKVIDIIHKANPAQTIFIVVKNVKDALTLVEGGVPIKE
                     INIGNIHNATGKEQVTRSIFLGEEDKAALKELSQTHQVTFNTKTTPTGNDGAVQVNIM
                     DYI"
     gene            complement(12871..14061)
                     /locus_tag="AC0DU4_001279"
     CDS             complement(12871..14061)
                     /locus_tag="AC0DU4_001279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003074342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="HIN4237239.1"
                     /translation="MIKKVTIEEIKSPERFLEVPLLTKEEVGQAIDKVIRQLELNLDY
                     FKEDFPTPATFDNVYPIMDNTEWTNGFWTGELWLAYEYSQQDAFKNIAHKNVLSFLDR
                     VNKRVELAHHDLGFLYTPSCMAEYKINGDGEAREAALKAADKLIERYQEKGGFIQAWG
                     DLGKKEHYRLIIDCLLNIQLLFFAYQETGDQKYYDIAESHFYASANNVIRDDASSFHT
                     FYFDPETGQPFKGVTRQGYSDDSCWARGQSWGVYGIPLTYRHLKDESCFDLFKGVTNY
                     FLNRLPKDHVSYWDLIFNDGSDQSRDSSATAIAVCGIHEMLKHLPEVDADKDIYKHAM
                     HAMLRSLIEHYANDQFTPGGTSLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDW
                     NLYW"
     gene            complement(14073..14507)
                     /locus_tag="AC0DU4_001280"
     CDS             complement(14073..14507)
                     /locus_tag="AC0DU4_001280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HIN4237240.1"
                     /translation="MKIVLVGHGHFATGIYSSLQLIAGNQENVEAIDFVEGMSADELK
                     QKILLAISNEEEVLILSDLLGGSPFKVSSTIMGENPAKTMNVLSGLNLAMLMEAVFAR
                     MAHSFDEVVNKSVVAAQGGVVNGKELFSTDAEEEEEDFESGI"
     gene            14779..15594
                     /locus_tag="AC0DU4_001281"
     CDS             14779..15594
                     /locus_tag="AC0DU4_001281"
                     /EC_number="1.1.1.69"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="gluconate 5-dehydrogenase"
                     /protein_id="HIN4237241.1"
                     /translation="MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVF
                     NDINQDLVNKGIEAYREVGIEAHGYVCDVTDEDGIQAMVKQIEQEVGVIDILVNNAGI
                     IRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRET
                     VSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFD
                     QFIIAKTPAARWGNPEDLMGPAVFLASDASNFVNGHILYVDGGILAYIGKQPE"
     gene            15613..16254
                     /locus_tag="AC0DU4_001282"
     CDS             15613..16254
                     /locus_tag="AC0DU4_001282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RpiB/LacA/LacB family sugar-phosphate isomerase"
                     /protein_id="HIN4237242.1"
                     /translation="MKIALINENSQASKNHIIYDSLKEATDKKDYQLFNYGMRGEEGE
                     SQLTYVQNGLMAAILLNTKAVDFVVTGCGTGVGAMLALNSFPGVVCGLAVDPTDAYLY
                     SQINGGNALSIPYAKGFGWGAELTLKLMFERLFAEEMGGGYPRERVIPEQRNARILNE
                     VKQITHNDLMTILKTIDQDFLKDTISGKYFQEYFFENCQDDEVAAYLKEVLAK"
     gene            16285..17286
                     /locus_tag="AC0DU4_001283"
     CDS             16285..17286
                     /locus_tag="AC0DU4_001283"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HIN4237243.1"
                     /translation="MTKILLFGEPLIRISPLDATSIGDHVASSTYFGGSEINIACNLQ
                     ALGISTKVFTALPANEIGDRFLTFLKQHQIDTSSICRLGDRIGLYYLENGFGCRQSEV
                     FYDRKHTSISQIRPNMLDMDSLFQGISHFHFSGITIAIGQEVRAILLLLLEEAKRRGI
                     VVSMDLNLRTKMISVLEAKYEFSKFARFTDYCFGIDPLMIDDQNLEMFPRDSASLEEV
                     ENRMRLLKEAYGFKAIFHTLRSSDEQDKNVYQAYALEERFEESVQLKTAVYQRIGSGD
                     AFISGALYQLLHHSSLKTTIDFAVASATLKCTLPGDHLSTSATSIENLLANAQDIIR"
     gene            17296..17925
                     /locus_tag="AC0DU4_001284"
     CDS             17296..17925
                     /locus_tag="AC0DU4_001284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="HIN4237244.1"
                     /translation="MTKSDTIIELKKQKIVAVIRGNTKKEGLQASIACIKGGIKAIEI
                     AYTNQYAGQIIKELVDLYQDDQSVCIGAGTVLDAVTARDAILAGANYVVSPSFHAETA
                     KMCNLYSTPYIPGCITLTEITTALEAGSEIIKLFPGSALSPAYISAVKAPIPQVSVMV
                     TGGVGLNNIPQWFAAGADAVGIGGELNKLASQGNFDGISEIAQQYVTLR"
BASE COUNT         5269 a         4025 c         3259 g         5385 t
ORIGIN      
        1 tgccgattgg gcgatttcct tcatcaaaac cagcacggtt acgacggata gcacgagcta
       61 caacttctac ggccttatct tgaccaatca ccttgtcttg caagcgatga gccatatctt
      121 tcaaacgttc gatatctgaa gctcccattt gcgatactgg gatacctgtc attcgttcca
      181 cagattcagc cacatcgttg acacttgcag tcactttcat atcttctgtg tggttttcga
      241 ttttcttttc caattctgca atgcgtgttt tatagtttag agctgcttca aaatcttctg
      301 cttcaactgc tttttcttgc ttgtcttttt ccgtttcgat ttctcgttca acagcatgca
      361 catctgttac tggatgttga gccgccaagt gagcagctgt tacatcgaca aggtcaatag
      421 ccttatctgg caagctacgt tgaggaatgt attgaacaga ataatccacc gctgctttca
      481 aaacttcgtc tggcaagatg acattgtgat gttgttgata gaggtcacga atgccttgaa
      541 gaatgttaaa agtattctct gctgaaggag cattgacctt cacttcgttg aaacgacgag
      601 caagagcagc attcttcaag atggtgttac ggtattcgtc ttgagttgtt gccccaatca
      661 ctgtcaattc tccacgagag agagctggct tgagaatatc cgcaagtcct ttagaaccac
      721 tgtctccacc agtgctacca gcaccaagaa tttggtgaat ttcatcaaag aagaggataa
      781 tattccctgc ttctttcact tcattgacta agttttggac attttcttca aagctaccac
      841 ggtattgagt accagcctca agacctgaga tatcaataga aataatttcc ttgttcttga
      901 tagcagcagg aacatctccg ttcacaatgg cttgcgctag accttcgaca actgctgtct
      961 taccaacacc tgcatctccg accaaaacag gattgttctt ggtgcggcgt gagaggattt
     1021 cagatgtttc ttgaatttcc ttgtttcgtc cgataacagg atccaactta ccctcacgcg
     1081 cttctgctgt caagtttcga cctagttttg caaggacacc gtcttgtttc atacctgatg
     1141 cctgttgtga catttgcaca tcagtttctg catttcctgg taattgacca gtcgtacgat
     1201 agtgagcaaa ttcctcaggt gtgacttcgc gcccattaat taagtaacgg cgattttcag
     1261 aactgtatcc tcgcatacca cccatcaatt ggttaaataa atcatccatg ttattaaaat
     1321 tattaaagtt gttattcata ttctttacct ctttttgttt acttagttat gattactgat
     1381 attgactatc tttgaccttt gttttaaaaa atttagacta gctaaaccgc taccctacgt
     1441 actatttctg gtttttcttt ttcaagcagg agtagaccat ctttacttct gaagatttct
     1501 agattaaaca tagaccccac ctctttctat tttactttaa ataagtgttc tagtaaggct
     1561 ttcatttacc ttacgttcat aatatactac attagtcaga aaaggtcaag gattttgact
     1621 ttaattgacc aatatttttt atctcttcga aaatctcttc aaaccacatc agcttcgcct
     1681 tatctacaac ctcgaaactg tatagtaaaa tgaaataaga acaggataaa tcgttcagga
     1741 cagtcaaatc gatttctaac aatgttttag aagtagaggt gtactattct agtttcaata
     1801 tattatattt tgagcagcct aaagttagct ttctagtttg ttctttgatt ttcattgtgt
     1861 atttaaacac aaaaacaccc tgaaacatca gggtgccatt cttacatcaa atacaaaatt
     1921 gcgagggtca ggagacttgc tagaagccca actccccaaa agaagaagtc aaccttccac
     1981 tcgctccaag gatttccttt accagacaat cccccaagct caaaatggtg atgtacaggc
     2041 gtcatacgga aaatacgttt accacctgtc agtttgaaat aactgacttg catcataaca
     2101 gaagttgttt caaaaacata cacaattccg ataatcaaga gagtccattc ctggtggaga
     2161 gccatagaga tagctgccag catcccacct agggccaaac ttcccacatc acccataaag
     2221 accttggcag gcttatggtt aaagatgaag aaaccgagca aaccaccaat catggcaaga
     2281 atcactagaa gaatatccat ctgaccttgc acataggcaa taactccata ggcaaacaaa
     2341 ctaatcacaa cggaaatact agctaaaccg tcaacaccgt ctgtcaagtt tactgcgttt
     2401 gaaaaaccga ctagccagaa aagagcgaag aaaatataga aaaatcccaa atgaactgga
     2461 taaccaaaga cagacaggat atcgccaccg cgctcataga aaagatagaa gataactcca
     2521 cctagaagct gaagagctaa tttttgctta ggattaagcc cctcattgat tttacgaaag
     2581 accttgagaa agtcatctaa aaatccgacc aagccataca agaccaagat gaacaaaatc
     2641 attcccacat tattgctgaa ttggctacta aatagggcga aaaagaaagc aaccaaaaca
     2701 gaagtaatca agaaaaccaa acctcccatt gtaggagtcc cagcttttgc ctgatgctgt
     2761 ttgacatcct catgcatctg ctggcctgta atttgcgcct ttctataaaa ttggataaag
     2821 gccggaattc ctactaaagt tagtaaaaat gtcacaattc cagcactgat ggaaataaac
     2881 atattagtct cctaaagtta atgtaatttt tttaatgtcc ttgatagctg tgttagcacg
     2941 aacatcttgc ttctgcacag tagagcccga gccttgaaat tcaagttcta tattgagcca
     3001 cttagcaagg gtctcagcag tctcctttgt ccaaccatac atatctggaa cctcctctgc
     3061 tttatcagat aagataagga cttgctggtt cggggcaaga ttcttccctt cttcagcaga
     3121 actgttttta atcttcgttc ctgttcccac aacgatgggt tgtacaagat tgcgacgcaa
     3181 ttcttctgct aaatcaccag gtgaaatatc cttgacactg ggcataggat aaggactttg
     3241 ttgacttact tgctccaaag ccttagctgt tgtttgaaga ttgagagagt ctttcatagc
     3301 tgaagcccgc tccaagatag gattggcaaa ttctcccaac tgaatacctg aataatgttc
     3361 aggttgttgg accgtcacat acaagataaa atcaggattt tcagccggac tcatcgatac
     3421 agccgagaaa atatagtcgg ttaacccgac tagataacca ccatttttct cgtcagcaat
     3481 ctgagccgta ccagacttga gggctacatt ttgcccagga acagttacag ttggcttgcc
     3541 tgtgctgtgg ttatacatgg ttccataaac cggatccgtc cctaccaaaa ccatgttagt
     3601 ccgagttaga ctagctgcat ctttagaaac aggatttccc acaatttctt tttgagattt
     3661 ccgagcagtt tgatcatttg gatcataaat ggcactaata aatttaggct ccagcatgac
     3721 accgtcatta gcaatagctg taaaggcacg aatcatttgc gtctgggtca ctgaaatccc
     3781 ttgtccaaat gagctttgcg caatgttgac aatattatcc gcaggaagct gaccagcata
     3841 ctcatccgtc aaaccgaaac gggtcggaac accaaattta aaacgattaa gataatcaag
     3901 ccaggtagca tctcccatct tttgctcaag gagggtcatc ccaacgttac ttgagtgtgc
     3961 aaaaccttga gaaaaagtca tcattctgcc accagtcaat ccttcattaa cgtcccaatc
     4021 tcgaatcgtg gcatctgcaa tttttaactc actactatta aagacttctc ctcctggaaa
     4081 ggtattatta tcaatagcag cagccaacat catcactttc atagtggaac ctggctcata
     4141 gttactttgg taaaggatat cacgccaaac aaagtcctct gtaatgcctt cttttgtatc
     4201 tgcatcaaag gtcggtcgtt gcgttgttgc cagaatttcc cctgttttag cactgaccaa
     4261 agtcgctgtc atgtactttc cttttacctt ctcttgaaaa gcatccatct gggtttccat
     4321 aaaggactgg agggggctgg aaatggttgt ataaacatcc ttaccgtcca tcgttcgttg
     4381 ggaaacttgt tctgttccgg gtacaatatt acccagacga tccttttcat aggtaataat
     4441 gccgtctgtc cctgcaagaa tactgttcaa ggaactctcc attccagagg ttcccagcaa
     4501 gctcttgctt ccatcttcat tttcatggag ctgagctagg ccgataaaac tagaagcaaa
     4561 ttgtccgttt gggtaactac gattgggact ggttgtaaaa tcaatcccct tgacctctgc
     4621 agcttccaat tcttttttga tagacatcat attggcatag gtaatcccat ttccctttgc
     4681 tccaaaggaa acttgcttga gattaggttg cgagagttgc tctcttacat aggattcttc
     4741 catgtccaga tacttatgaa agacctctgc aaccttgtta aattgtgttt tttctacgta
     4801 aagaatctta cccgttgctg acttatagtt ctcatcaatg accgcataga cattatagga
     4861 ggttgcatcc tcagcaatcg ggactccatt tcggtcataa atagtcccac gtttggcagg
     4921 aactgtacgg gtggtttgat gaaccttctt agcttccttc gctaaatctg ttccaaagcg
     4981 agtgcctgtc ccaataatga ccgcaaaatt gactaaaaaa atggcaaaaa caaagacaga
     5041 taataaactc agactttttc caactctgcg tctgttttca gccggcgatt tccgattttt
     5101 ggtcgcataa cggattactc tttttgtcca cttcatatct tactccgcta ttctaatatt
     5161 ttcattgttt aattgcaaat cgtgtgaatt ggcaatttct ttcaaacgtt ctgcacgtaa
     5221 tagttcattg acctcttgct tggcatcgtc caattcggtc ttcttttcct ctatctgcgc
     5281 attgattttt gtcaaatcat tctgcacttg caagagcttg gtctgcataa aaataatact
     5341 aatggctaca ataagagtgg ttacagcaat ggaaaagtaa aaagcttttt ccacacgcga
     5401 aaaccgttta agttgcatct gtagtatttg acctgttttt tccatttttt ctgccatctt
     5461 tttccctctt acttgtgaat ttttctgacc acgcgcaact tggctgagtg cgagcggtta
     5521 ttggcttcta actcttccgc acttggcaag attggcttac gggacaccaa ttccatcttg
     5581 ggcttgcgat catctgggat gaaaggcaag ccttttggaa cttcaactgt tgaagcttcc
     5641 ttgaacaatt gcttagtcaa gcggtcttct aaggaatgaa aggtaatcac tgaaattcta
     5701 ccatccagag ccaacatatc catagcctgc tggatggact catctgccgc ccccagttca
     5761 tcattgactt caattcgaat agcctggaaa atctgcttag caggatgacc cttcttcttg
     5821 agttccttgg caggtttgac caacttgata atctctgcta actcagtcgt tgtctcaatc
     5881 ggcttcactt cacgcgcttg ctcaatctta cgcgcaatct gtttagagaa tttgtcctct
     5941 ccatacttga agaaaatacg aaccaagtca tgatagtcat aattgttcac cacttcatac
     6001 gctgtcagac tagcatcctg attcatccgc atgtccagtg gcgcatcctt tttataagaa
     6061 aaaccacgct cacgctggtc taattgagga ctagacactc ccaagtcata acaaattcca
     6121 tcaatttcct gaacaccagc ttcgcgcaaa cgtgcctgta aatgacggaa gttatccttg
     6181 ataaaggtca ccattccctt ctcaatgtaa ggtgccaagc gtttttgcgc attgtcaatg
     6241 gcattctgat cctggtcaaa ggcatagaga tggccttttt cacttaattt acttaataaa
     6301 tactcgctat ggcctgctcc acccaaagtc gcatcaacgt agataccgtc aggttttacg
     6361 tcaagcatat caatcgtttc gtggagtaag accgttacat gatgaaattc ttttgtcata
     6421 tcttatctat tttaccacaa atccgaccag cttgcacttg tcagacaaat aggacaagga
     6481 gactactatt tcttcaaaaa atatgtcaaa aatacttgac actttatgtt taaaagacta
     6541 taatatagtc aaatatatac gacataaatc agaaagaaga acagatgaat cgtgtgaaag
     6601 aatttcgcaa ggaactgggc atttcccagc tcgagctcgc caagaatatc ggtgtctcga
     6661 gacagactat caatatgatt gaaaacgaca agtacaatcc aaccttggaa ctctgtctca
     6721 atctcgcccg cagcctccaa actgacctca acagtctctt ttgggaggaa gatttttaaa
     6781 aaaggagcaa actcatgaaa aaagaaaaga aacagttacg ttatcctggt ctgaaagcag
     6841 gttcgattta tggaacagtg atatttttta taattccact cattgatacc ctaacaagtg
     6901 aaaatccaaa ttttatcagt tctcttctaa atacaaaaca tatttttaaa actatactgg
     6961 gagctttctt tttcggagtg atgatacata ttgtcgactc acttcgtatt gcaagagcta
     7021 aaaaagacca ggattaggag gtaccttatg aaatcactag ctagactact gatcattcat
     7081 gtttttatca gtattttcct tttctttgcc cttatttcag gagctgtttc tcatacagtt
     7141 ttactactcc tactcctctt tcttcctgcg ctcaataaag gacttgagaa aatacaatca
     7201 aaacggatac ctgtcctcaa cgcagccctc ttctttctcc tcatatcctt tccacaactt
     7261 ttaaccaacc ctgtccaatg gaaattttca atattcctag tcgtaaccat catttcaagt
     7321 ttggcctact tctataactt ttatcaagta gttaaagaag tagatcaaaa acagttgatt
     7381 taggagcttg ctcccataat ttctcatttc ataggcaaat aatcccacct agcttgttct
     7441 aggtgggatt attttatttc ttaacagaga ttgcaagtca ttttccttca ttttagaaag
     7501 tcgactcttt ccaattcaca ctacaatcca agacttgttg cctttcttct tgattgcggc
     7561 cttcaatctg gtcaatcaaa atctttgtag cctgttgtcc ttcctcaaag gagggctgaa
     7621 ccagcgtcga aacacttgga gaagaaaagc aagtccactc cgtattgtca aaaccaatca
     7681 acccaacttg tggcaagtta taattcaact ctttgataac ggtaaagact agaggtaggg
     7741 cccaacagtt agggataaat accagagttt tttcatcggg atcgatttct ttttgtaaaa
     7801 attctttaat ttgttccaaa ttcgtatgct tatcttcaat ggttagactg gcgtgacgca
     7861 tattagcatc tgttaaagca tccacaaaac cacttgcccg ctcaatccga gtactcaaac
     7921 gactcgtatc cgctgtaatc aagagaaaat gctcataacc tttttcgata caggactggg
     7981 tcatgtcata aacggcatca tagttattgg ttttaaccca gctagtccgg tgttcataga
     8041 gctgactatc aaaaaagacc attttcttct ttttctcatc gatgatacga gaatattttc
     8101 ggaaattaga ggtcggctga ataataaagc cgtctactcc caagagaagc atgctttcaa
     8161 tataccggtc ctcactctct tggctgtaat tactatttcc tatcattacc tggtagccat
     8221 tctggctggc gatatcctca attcccttaa caatttggtt tgagaaactg ttggtaatat
     8281 caccgatcaa aacaccgatt aattttgttc gtttggagtt taagctacgc gcaacaatgc
     8341 tcggtttgta atttgtttca tgaataactt tttcaatctt ttcacgtgtc tcttgggaca
     8401 ttttttcata tttcccgttt aggtaaaatg acacggttgt tttcgaggtc tgagccattt
     8461 ccgcaatgtc ttttatggtc agtttcttct ccaatctaaa acacctccta ctaatactta
     8521 ttataacata ttcactattc aaaatgccta tttctagcac tgcaagcgaa tcattctctc
     8581 atttatttta tcatatacta gacattttcc acgcattttt gttccgtcaa cgaggcacaa
     8641 tttttcacct acaccaatat cctcgcttaa taacagaatc agcttgtctg tttcgtcatt
     8701 tttcacttca aaagccagag cattttccac ttcacgatca tctgtctggt agacagaatg
     8761 acggatgatt tcaaaactct catgcgcaat gatggtataa tccagcatct gattctcaaa
     8821 gaattggcgc ttggtgagtt tgctacttct ttcaagctca ttgtatttag gagaaatgat
     8881 ggtatcttcc aaatcaaaat caacttcact ccatagtctc aactgattga ttttcccatc
     8941 ttgataggtc acatccttgt caaggataaa ctgagtcaac gcctcatgct gaccttgaca
     9001 cctgatgtca tctaccaaga gccagacatc ctctaccaac atgaggattt ttctcttgtg
     9061 aagataaggc aaatcaggtt ctgctgacca ataagccccc tcaatataat gcactccctc
     9121 cctttcttta tggtgacaaa acagggagtg aggatagtat tcatattccc aggatcccgt
     9181 gattctttcc ggagctttcc catctacaat gcaggtcgaa tgactccaag cactatttaa
     9241 gagataacgt tcatatatct cccgataaga ataacgccca gcatctatga aaataggttg
     9301 gccttgatac tgtaagcaaa aactattctc gtcactatgg ctatgggcac ttcctagcgg
     9361 accatttttg aaaaatagat aacgatgttc atccttaatg cagacatgtc cagagtcttc
     9421 aaagatcatg gacttaggct gccaagctct cctttcaaat tcctgcagtc gcttgacctt
     9481 ttctcgcccc aggaacaaga ggctaagcaa atcgacttta acatccagac cgttaagaag
     9541 gtcttccttg ttcaaaacca cagcagacag gctcaaaatt tctgtcgttt ctgtagaatc
     9601 gctatcacca aaagccaaag ttcgtccatc taagcctgtc atcatttgaa tataggtcgc
     9661 catcttttcc agcaactctc ggtaactatc ttgcaagtct ggaagcaaga gacacaaatc
     9721 cagcaaggct ttataaacct ctacatgata gagaatcgac tgttcaaact ggcttccatc
     9781 tcctaaaatc tgtgtctcaa tttgctgttt caactcctct gaagcaaaat ggtaagcttc
     9841 ttctagatcc atcttatctg aaaagaaata atagatagca agcatcggaa ttgtttgtaa
     9901 aatcccccag ttactaaggg tgtacttggc gcgatagtgg cttttcataa agtcaatctg
     9961 cttttctaga ctgaccaaaa ttttctctag ttctttctcc tctagcaagt caaatttcaa
    10021 gaggagcaag agtagtttca accaagtaaa ggaacgaata cccgtatcca aggttctagt
    10081 catcaaggat tgaggagaaa attctctcac ctgctcaatc caatcaaata gaaagaactt
    10141 gcacttttga atatagctct tatctccttc taccagatac cctatcataa actgcaagag
    10201 atattcttgt cgattgagca tataagccca ttctggatca tcttcaaata cttgatccca
    10261 taccatcggc tggatttgat ggatttttga acaaggctcc atatcccaag gactatcaaa
    10321 cataaaacga ttgtccatca agcgttcaag ggaactcttg actttctcat agtcttttga
    10381 acagtgggac aagatataat cacgacattg gtttccatcg attctttcaa aaaattgtct
    10441 tctttcttct ttcattatct attaccagaa aaagaactac ttaaaaagca gttcttttgt
    10501 ctttcccatt acactttcct tttctacata gatgaccaca ccttttgcaa tctgcaagga
    10561 gaccaagtca tctttgatag aaatgatttt tccatgaatt ccagacaata acaacacttc
    10621 atcaccagat gttaaagaag ctaaatactc ttgtcgttgc tccatctgtt tgcgaagcaa
    10681 cttttgctga cgaatagaat gaaagcttga cagtaaaagg ggactcactg ccaagacaat
    10741 cactattcca taaaacaatg ttgtatccat taagctataa tcttaagcca gcttccgata
    10801 attccgatga taactgttaa aataacgagt ttatatgttg tccatttctt ttctttgatc
    10861 aagtagtaaa ctaaaagtgt aaatagggct ggtagaagag ctggagcaac cttatcaagc
    10921 attccctgaa tacttacgat actttgttta gcgtctgctt taacttcccc tgcagcaaag
    10981 gtaatcggca ccataatctt aacagatgtc gctgccaaac cagcaattac ggttacaccg
    11041 ataatattgg caatacgaga aatcgttgcc atctgttcgc ttagtttatc aatcacagtt
    11101 gttcctagtt tgtatccata cagaccagtt gacaatttaa tcgctgttaa aatcgtattc
    11161 atcgcaagga agaacaagat tggaccgaca accaagcctt cttgagcaaa cgaagctgcg
    11221 atggttgaga acaatggagc taaacagaat tgagaaagag aatccccaat acctgccaat
    11281 ggtcccatca aggccatctt gatgctacgt gtttcttttg ccggacggcc attttccaac
    11341 attacaagat gcaagctggt aataaaaggc aggaagtgtg ggttggtatt atagaattca
    11401 cagttttctt ccaaggcttg gtagaaacct tcctgatcct ctccatagtg ttttttcaaa
    11461 gcaggataca tcacattggc atatcccaac ccttgatagt tactatagtt aaatccattt
    11521 tgacaaaaga atgcccgcaa agacgtttta agataatcac gttttgttaa tttgttagat
    11581 ccagtcatcg tgtgcttcct cctctaccac atgatccgct gtttttggct tgttataaaa
    11641 ttcaatcaaa gcaaagatag tacctacaat tgcaatacca attgttggga tgtttagata
    11701 agctgcacaa acatatccca acaagacaaa gggaatcaac tctttcttag ccatcactga
    11761 caagatcatc gcaaaaccga tagctgggag cattttacca gcaactgtca aacctgtaag
    11821 caataccggt ggaatgtagt ctacgagttt caacaaggta tccattgaaa gggcacccaa
    11881 gcaacccaag gtaaatccaa taaaggcaaa caaccaaatt gttgcattta gagtgaactt
    11941 aaatttcttc aaattatggt ttttcaagtg cttcatcgct gtttcaggcg caccagcacg
    12001 tacagtgtag gcgaaagttt gtaagaattg aatcgccaca gcaatcggag tagagagggc
    12061 aagagccgct tctggactga ctttaccagc actagtgata gccatcaagg taccaaagat
    12121 accaggtccg attgggtttg gtggaacagt acctccagca ccaacaccga atcccatata
    12181 agccaattca ccaatagctc ccattgcaag agcagtaggc agatcaccta gaataattcc
    12241 gacaccaaat gacagaacaa tgcatctatt ggtgtaaatt cctaacagca ttccactaaa
    12301 acagaaagct gtccataatc caattaaaat cgcttgaaat acattaatcg acataacgat
    12361 ctcctctttt aaatatagtc cataatgttg acttgaacag ctccatcatt tcctgttgga
    12421 gttgttttcg tattaaatgt tacttgatga gtttggctca attccttgag ggccgccttg
    12481 tcctcttcac ccaggaagat ggagcgtgtc acttgctctt taccagtagc attgtgaatg
    12541 ttcccaatat tgatttcttt gatagggaca ccaccttcta ccaaggttaa agcatccttc
    12601 acattcttta caacgataaa gatcgtttga gcaggattag ccttgtgaat gatatcaatc
    12661 accttttgca aagggaagaa acgcatggca actgagtctg gcacaactgt tttcatcaga
    12721 gtttgttgca tcttgtccgt gcttacttcg tcattggcaa caatgaccgt attacaacct
    12781 aggtatttta cccaaagttg tccttgtcca tgaatcaacc gttcatcgat acgggtcata
    12841 ataatatttg gcattgtcat atttctcctc ctaccaatat aggttccagt ctttgtagaa
    12901 acggataagg gcttctaggt aatagtagtc accccagata ttgccttcat ccactccttt
    12961 acctgaatgc catgagtaca caccgtggag gagacttgtc ccaccagggg taaattgatc
    13021 atttgcataa tgttcgatca aggaacgaag catggcatgc atagcatgtt tataaatatc
    13081 tttgtcagca tccacctctg ggagatgttt tagcatttca tgaatcccac agacggcgat
    13141 agctgttgct gaagaatctc gtgattgatc actaccatca ttaaaaatca aatcccaata
    13201 ggacacatga tcttttggca gacgattcaa gaaataattg gtcacaccct taaacaagtc
    13261 aaagcaggac tcgtctttta agtgacgata agtcaaagga ataccataaa ctccccatga
    13321 ctgaccacgt gcccagcatg aatcatcact atacccttgt ctcgttacac ctttaaaggg
    13381 ttgacctgtc tcaggatcaa aatagaaggt gtggaaggac gaagcgtcat cacggattac
    13441 attattagct gaagcataga aatggctttc tgcaatatcg tagtattttt gatcgcctgt
    13501 ttcttgataa gcaaagaata agagttggat attgagcaag caatcgataa tcaaacggta
    13561 atgctctttc ttgcccaagt ctccccaagc ttgaataaaa ccaccttttt cttgatagcg
    13621 ttcaatcaac ttatctgcag ctttcaaggc tgcttctcta gcctctccat ctccatttat
    13681 cttatattca gccatacaag acggtgtgta caagaagccg agatcatggt gagccaattc
    13741 tactctctta ttgacacgat ccaggaaaga aagaacattt ttatgagcga tgtttttaaa
    13801 tgcatcctgt tgactgtatt cataagccaa ccacagttct cctgtccaga aaccattggt
    13861 ccattccgtg ttatccatga ttggatagac attatcaaag gtagctggcg tcgggaaatc
    13921 ttccttgaaa tagtcaaggt tgagttctaa ctgccgaata accttatcga ttgcctggcc
    13981 gacttcttct ttcgtcagaa gtggtacttc taagaagcgc tcaggcgatt ttatttcttc
    14041 aatcgtaacc ttttttatca ttctttcacc ctttaaatac ccgattcgaa atcttcttcc
    14101 tcttcctctg catccgttga aaacaattct ttaccattta cgactccgcc ctgggccgcc
    14161 actactgatt tattaacaac ctcatcaaag ctatgagcca ttctagcaaa aactgcttcc
    14221 attaacatgg ctaagttcaa acccgagaga acattcattg ttttggctgg attttctccc
    14281 attatggtag aagaaacctt gaatggcgat cctcccaaga gatcacttag gattaaaact
    14341 tcttcttcat ttgaaattgc aagtaagatt ttttgcttga gttcatctgc tgacattcct
    14401 tccacaaagt caatcgcctc cacattttct tgattacctg caatcaattg taaagaacta
    14461 taaatccctg tagcaaaatg tccatgccct acaagtacaa ttttcatctt ttctcctttc
    14521 ttgtttaggt ttaccggttt actttatatt ccccattgta atcctttatt tttatcttgt
    14581 caatagtttt tttaaaaaaa tattagcgct ttcattatct ttttaaccat tttaatagac
    14641 agaaatttca aaatcttccg tttttttagg aaaataaatc tttttataaa taaaaatatt
    14701 tatttattga caaaaccggt ttactagaat ataatttggt tatagagaag tcttaacaaa
    14761 tttgaaagga agtatcaaat gacaaataca tcattctcaa ttgagcagtt ttctttaaaa
    14821 ggaaaaattg ctctcatcac cggcgcttct tatggaattg gatttgctat tgccaaatcc
    14881 tacgctgaag ccggcgctac tattgtcttt aacgatatca atcaagatct ggtcaataaa
    14941 gggattgaag cttatcgtga agttggcatc gaagcccatg gatatgtctg tgacgtgaca
    15001 gacgaggacg gtatccaagc catggtcaag caaatcgaac aagaggttgg tgtcattgac
    15061 atcctcgtta ataacgctgg tattatccgc cgagttccaa tgtgcgaaat gagcgccgct
    15121 gatttccgta aggtcatcga tattgactta aacgcaccat ttatcgtttc aaaggcagtt
    15181 attccttcta tgataaagaa agggcatgga aagattatca atatttgttc gatgatgagc
    15241 gaactgggac gtgaaacagt tagcgcttat gctgctgcta aagggggctt gaaaatgttg
    15301 acccgcaaca ttgcgtctga atacggtgga gccaatatcc aatgtaacgg aattggaccg
    15361 ggttatattg ccactcctca aacagcacct cttcgtgagt tgcaagaaga tggttctcgc
    15421 cacccatttg accagttcat cattgcaaaa acacctgctg cacgttgggg aaatcctgaa
    15481 gatttgatgg gccctgctgt ctttctcgct agtgatgcca gcaattttgt caatggccac
    15541 atcctatatg tagatggcgg tatcttagcc tacatcggaa aacaacctga gtaaaaatag
    15601 aaagaagatc ttatgaaaat cgcattaatc aatgaaaata gtcaagctag caagaatcac
    15661 attatttacg atagtctaaa agaagcgaca gataaaaaag actaccaatt atttaactat
    15721 ggtatgcgtg gagaagaagg agaaagtcaa ttaacttatg tgcagaacgg actaatggct
    15781 gccatccttt taaatacaaa ggcagttgac tttgttgtta ccggctgtgg tacgggtgta
    15841 ggggctatgc ttgctttaaa cagcttccct ggtgttgtct gtggtctagc agtggaccca
    15901 actgacgctt acctttattc tcaaatcaat ggtggtaacg ccttgtctat cccttatgcc
    15961 aaaggatttg gctggggggc agaactgacc ctcaaattga tgtttgaacg cttatttgct
    16021 gaagaaatgg gcggtggcta cccaagagaa cgtgtaatcc ctgaacaacg taacgctcgt
    16081 atcttaaacg aggtgaaaca aatcacccac aatgatttga tgaccatcct taaaacaatc
    16141 gaccaagact tcctcaaaga caccatctct ggcaaatact tccaagaata cttctttgaa
    16201 aactgccaag atgatgaagt cgctgcttat ttgaaagaag tattagccaa gtaaagctat
    16261 tctaaaccag aaaggaacta atggatgacg aaaatattac tgtttggcga accattaatt
    16321 cgaatctcac cattagatgc caccagtatc ggcgatcatg ttgccagttc gacttatttt
    16381 ggcggatcag aaattaacat cgcttgtaat ttgcaagccc tgggtatctc aacgaaagtc
    16441 tttaccgcac tccctgccaa cgagattgga gatcgttttc tcacattctt gaaacagcac
    16501 caaatcgata ccagttcaat ctgtcggctt ggcgatcgaa tcggcctcta ctatttggag
    16561 aacggctttg gttgtcgtca aagtgaagtt ttctacgatc gtaagcatac gagtatcagc
    16621 cagattcggc caaacatgct agatatggat tctctctttc aggggattag ccattttcat
    16681 tttagtggaa tcaccatagc tatcggtcaa gaggtccgtg cgatccttct cctactcttg
    16741 gaagaagcca agcgccgagg aattgtcgtt tcaatggatc tcaatctgag aacaaagatg
    16801 atttcagtcc tagaagccaa gtatgaattt tctaagtttg cacgttttac tgactattgc
    16861 ttcggtattg atcctctcat gattgatgac caaaatctag agatgtttcc aagagacagt
    16921 gctagcctag aagaggtgga aaatcgcatg cgacttttaa aagaagccta tggtttcaag
    16981 gccattttcc ataccctccg ctctagtgat gagcaagaca aaaatgtcta tcaagcctat
    17041 gctctggaag aacgatttga agagtctgtc caactaaaaa ctgcagtcta tcaacgaatt
    17101 ggtagcgggg atgcctttat atctggtgcc ctttaccaac tactccatca ttcctcccta
    17161 aaaactacca ttgactttgc agttgcgagc gcaactctca aatgcactct tccaggagac
    17221 catctctcca cttccgcaac tagtattgaa aatttactgg caaatgcaca agatatcatt
    17281 cgttaggaga attacatgac caaatcagat acgattattg aactaaaaaa acagaaaatt
    17341 gtcgctgtca ttcgaggaaa tacaaagaaa gaaggactgc aagcctcgat tgcttgtatc
    17401 aagggcggta tcaaagctat tgaaatcgcc tataccaatc agtatgcagg acaaatcatc
    17461 aaggaacttg tagacttgta tcaggacgat cagagtgttt gtatcggtgc aggtactgtg
    17521 cttgatgccg taactgctag agatgccatt ctagccggag caaattacgt tgtttctcca
    17581 tctttccatg ctgaaactgc gaaaatgtgc aatctctaca gcacaccgta cattccaggc
    17641 tgtattaccc tcacagagat cacgactgca cttgaagccg gtagtgaaat catcaaactc
    17701 ttcccaggta gtgctctcag tccagcatat atctctgcag tcaaggcacc gatcccacaa
    17761 gtttccgtaa tggtaaccgg aggagtcggt ctaaacaaca tccctcaatg gttcgctgct
    17821 ggtgcagatg ccgttggaat tggtggcgaa ctcaataaac tcgcttccca aggcaacttt
    17881 gacggcatca gcgagattgc ccaacagtat gttacactca gataaaatca taactacc
//
LOCUS       DBMVGT010000034        17290 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.034, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000034 DBMVGT010000000
VERSION     DBMVGT010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 17290)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17290)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17290
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.034"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            1..610
                     /locus_tag="AC0DU4_001285"
                     /pseudo
     CDS             1..610
                     /locus_tag="AC0DU4_001285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            510..956
                     /locus_tag="AC0DU4_001286"
     CDS             510..956
                     /locus_tag="AC0DU4_001286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864098.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009009 - site-specific recombinase
                     activity [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HIN4237245.1"
                     /translation="MRKHGLISKSTSKRYYQVAIPFMRLFCLVLVSIDYINCLSETTD
                     KNWHKSDRVFVTNTGKTVHSSILSKSLQRANERLKKPIPKHLSPHIFRHTTISILSEN
                     KIPLKTITDRVGHSDSEVTTSIYTHVTKNMKDEAINVLDKVMKKIF"
     gene            complement(1094..2398)
                     /gene="eno"
                     /locus_tag="AC0DU4_001287"
     CDS             complement(1094..2398)
                     /gene="eno"
                     /locus_tag="AC0DU4_001287"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="surface-displayed alpha-enolase"
                     /protein_id="HIN4237246.1"
                     /translation="MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTG
                     EHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPN
                     KGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPI
                     AFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDG
                     VETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQID
                     YLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQE
                     GAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQ
                     IKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK"
     gene            2562..3008
                     /locus_tag="AC0DU4_001288"
     CDS             2562..3008
                     /locus_tag="AC0DU4_001288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000131081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YueI family protein"
                     /protein_id="HIN4237247.1"
                     /translation="MTDLSKQLLEKAHGGLKINPDEQRRYLGTFEERVLGYVDIDTAN
                     SPQLEKGFLFILENLQEKAEPLFVKISPTIEFDKQVFYLKEAKETDSQATIVSEEHIT
                     SPFGLVIHSNAPVQVEEKDLRLAFPKLWEVKKEEPAKTSLWKKWFS"
     gene            complement(3005..4120)
                     /locus_tag="AC0DU4_001289"
     CDS             complement(3005..4120)
                     /locus_tag="AC0DU4_001289"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008887 - glycerate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0031388 - organic acid phosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
                     /protein_id="HIN4237248.1"
                     /translation="MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPAGDG
                     GEGTVDAIRHSLDLKEKWIQVTDPFGQKEAMRYFQKGELALFEVADLVGLGKIPLEKR
                     NPLQIQTCGIGELILHLISKGIKDIYIGVGGTASNDGGLGIAAGLGYQFYDRDGNVLP
                     ASDQSLLNLASVSTENCYKIPEGVQIHILADVVSPLCGHQGATYTFGNQKGLHPTMFA
                     VVDQAIQDFYEKFSPATLEIKGAGAGGGLAGGLCAFAQASIVSGIDTCLDLINFDKKV
                     SDADLVVVGEGRLDSQSFAGKAPIGVAKRTPVGVPVIAICGSLAEDLPPLPFENIQAV
                     FSILEKSEPLEDSLKNASLYLERTAANIGHLLNMCKI"
     gene            complement(4129..4458)
                     /locus_tag="AC0DU4_001290"
     CDS             complement(4129..4458)
                     /locus_tag="AC0DU4_001290"
                     /inference="COORDINATES: protein motif:HMM:NF019887.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase family protein"
                     /protein_id="HIN4237249.1"
                     /translation="MERLAKSLGIAYFTANQLEVKEGLLTGKLVGQIISPQVKKETLE
                     KWRKKLKLSKERTVAIGDGVNNLLMLKSAELGIAFCSKEMLKKEIPHHVDKRDFLEVL
                     PLIDCLE"
     gene            complement(4403..4774)
                     /locus_tag="AC0DU4_001291"
     CDS             complement(4403..4774)
                     /locus_tag="AC0DU4_001291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family phosphatase"
                     /protein_id="HIN4237250.1"
                     /translation="MSQVKGLCVLDVDGTLILEEVIDLLGREAGHEAEISQITSRAMR
                     GELVFESSLRKRVSLLEGLPILVFDNVFNSIHLSLNVPEFISILQKNGILVGLVSGGF
                     TPIVGEISKIPWYCLFHCQPA"
     gene            complement(4833..6266)
                     /gene="glgA"
                     /locus_tag="AC0DU4_001292"
     CDS             complement(4833..6266)
                     /gene="glgA"
                     /locus_tag="AC0DU4_001292"
                     /EC_number="2.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004373 - alpha-1,4-glucan
                     glucosyltransferase (UDP-glucose donor) activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen synthase GlgA"
                     /protein_id="HIN4237251.1"
                     /translation="MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYY
                     DMVEAKFGNQIEDVLHFEVSVGWRRQYCGIKKTVLNGVTFYFIDNQYYFFRGHVYGDF
                     DDGERFAFFQLAAIEAMERIDFIPDLLHIHDYHTAMIPFLLKEKYRWIQAYEDIETVL
                     TIHNLEFQGQFSEGMLGDLFGVGLERYADGTLRWNNCLNWMKAGILYANRVSTVSPSY
                     AHEIMTSQFGCNLDQILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAK
                     NKAKLQERVGLPVRADVPLVGIVSRLTRQKGFDVVVESLHHILQEDVQIVLLGTGDPA
                     FEGAFSWLAQIYPDKLSTNITFDVKLAQEIYAACDLFLMPSRFEPCGLSQMMAMRYGT
                     LPLVHEVGGLRDTVRAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNL
                     QKQAMESDFSWDTACKSYLDLYHSLVN"
     gene            complement(6263..7402)
                     /gene="glgD"
                     /locus_tag="AC0DU4_001293"
     CDS             complement(6263..7402)
                     /gene="glgD"
                     /locus_tag="AC0DU4_001293"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008878 - glucose-1-phosphate
                     adenylyltransferase activity [Evidence IEA];
                     GO_process: GO:0005978 - glycogen biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase subunit
                     GlgD"
                     /protein_id="HIN4237252.1"
                     /translation="MKIDKYSAILGNTVGFHNMSTLTDHRPVASLPFGGKYRLIDFPL
                     SSLANAGVRSVFGIFQQDNISSVFDHIRSGREWGLSTLLSHYYLGIYNTRVESSTVGK
                     EYYQQLLTYLKRSGSNQTVALNCDVLINIDLNQVFHLHSTTKEPITVVYKKLAKKDIS
                     EVNAILDVDETDHVLSHKLFDSKSTAETFNMSTDIFVVDTPWLIEHLEEEAKKEHPKK
                     LRYVLRDLAVKEGAFAYEYTGYLANIHSVKSYYQANIDMLESQKFYSLFSPNQKIYTK
                     VKNEEPTYYANTSKVSTSQFASGSIIEGQVANSVLSRNIHVHKDSLVKDSLLFPRVVI
                     GEGAQVEYAILDKGVEVEPGVVIRGTAEHPVVVKKGAKVTEDIHS"
     gene            complement(7392..8534)
                     /locus_tag="AC0DU4_001294"
     CDS             complement(7392..8534)
                     /locus_tag="AC0DU4_001294"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000787267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008878 - glucose-1-phosphate
                     adenylyltransferase activity [Evidence IEA];
                     GO_process: GO:0005978 - glycogen biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="HIN4237253.1"
                     /translation="MKNEMLALILAGGQGTRLGKLTQSIAKPAVQFGGRYRIIDFALS
                     NCANSGIHNVGVVTQYQPLALNNHIGNGSSWGLDGINSGVSILQPYSASEGNRWFEGT
                     SHAIYQNIDYIDSVNPEYVLILSGDHIYKMDYDDMLQSHKDNNASLTVAVLDVPLKEA
                     SRFGIMNTDANNRIVEFEEKPAQPKSTKASMGIYIFDWQRLRNMLVAAEKSKVGMSDF
                     GKNVIPNYLESGESVYAYEFSGYWKDVGTIESLWEANMEYISPENALDSRNRQWKIYS
                     RNLISPPNFLGANAHVEDSLVVDGCFVDGTVKHSILSTGAQVREGAEVLDSVIMSGAI
                     IGQGAKIKRAIIGEGAIISDGVEIDGTDEVQVVGYNEVVGVATDED"
     gene            complement(8524..10452)
                     /gene="glgB"
                     /locus_tag="AC0DU4_001295"
     CDS             complement(8524..10452)
                     /gene="glgB"
                     /locus_tag="AC0DU4_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003844 - 1,4-alpha-glucan branching
                     enzyme activity [Evidence IEA];
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_function: GO:0043169 - cation binding [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0005978 - glycogen biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="1,4-alpha-glucan branching protein GlgB"
                     /protein_id="HIN4237254.1"
                     /translation="MDNREALKTFMTGENFYLQHYLGAHREELNGEHGYTFRVWAPNA
                     QAVHLVGDFTNWIENQIPMVRNDFGVWEVFTNMAQEGHIYKYHVTRQNGHQLMKIDPF
                     AVRYEARPGTGAILTELPEKKWKDGLWLARRKRWGFEERPVNIYEVHAGSWKRNSDGS
                     PYSFAQLKDELIPYLVEMNYTHIEFMPLMSHPLGLSWGYQLMGYFALEHAYGRPEEFQ
                     DFVEECHTHNIGVIVDWVPGHFTINDDALAYYDGTPTFEYQDHNKAHNHGWGALNFDL
                     GKNEVQSFLISCIKHWIDVYHLDGIRVDAVSNMLYLDYDDAPWTPNKDGGNLNYEGYY
                     FLQRLNEVIKLEYPNVMMIAEESSSATKITGMKEIGGLGFDYKWNMGWMNDILRFYEE
                     DPIYRKYDFNLVTFSFMYVFKENYLLPFSHDEVVHGKKSMMHKMWGDRYNQFAGLRNL
                     YTYQICHPGKKLLFMGSEYGQFLEWKSEEQLEWSNLEDPMNAKMKYFTSQLNQFYKDH
                     RCLWEIDTSYDGIEIIDADNRDQSVLSFIRKGKKGEMLICIFNMVPVERKDFTIGLPV
                     AGIYEEVWNTELEEWGGVWKEHNQTVQTQEGLWKDYEQTLTFTLPAMGASVWKIKRRL
                     KSTKTVTNKNQKGVENEK"
     gene            complement(10917..12341)
                     /locus_tag="AC0DU4_001296"
     CDS             complement(10917..12341)
                     /locus_tag="AC0DU4_001296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HIN4237255.1"
                     /translation="MTRYQNLVNGKWKSSEQEITIYSPINQEELGTVPAMTQTEADEA
                     MQAARAALPAWRALSAIERAAYLHKTAAILERDKEKIGTILAKEVAKGIKAAIGEVVR
                     TADLIRYAAEEGLRITGQAMEGGGFEAASKNKLAVVRREPVGIVLAIAPFNYPVNLSA
                     SKIAPALIAGNVVMLKPPTQGSISGLLLAKAFEEAGIPAGVFNTITGRGSEIGDYIIE
                     HKEVNFINFTGSTPIGERIGRLAGMRPIMLELGGKDAALVLEDADLEHAAKQIVAGAF
                     SYSGQRCTAIKRVIVLESVADKLATLLQEEVSKLTVGDPFDNADITPVIDNASADFIW
                     GLIEDAQEKEAQALTPIKREGNLLWPVLFDQVTKDMKVTWEEPFGPVLPIIRVASVEE
                     AIAFANESEFGLQSSVFTNDFKKAFEIAEKLEVGTVHINNKTQRGPDNFPFLGVKGSG
                     AGVQGIKYSIEAMTNVKSIVFDVK"
     gene            complement(12886..15165)
                     /gene="pulA"
                     /locus_tag="AC0DU4_001297"
     CDS             complement(12886..15165)
                     /gene="pulA"
                     /locus_tag="AC0DU4_001297"
                     /EC_number="3.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051060 - pullulanase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I pullulanase"
                     /protein_id="HIN4237256.1"
                     /translation="MYNYPMRIHYHRKNGEYDTCSFVKSQDQRIDLLTYKEDYFGALF
                     SFEHPSSHVIESLNFVVHTGQTSKEYSIRFNHYPLLTEVWILEGDDRIYYSENPAIAS
                     PFYKNQNPFAFDKAINSASFDHHWGYQGELGCRVEDNQAHFSLWSPTATEVQVVVYES
                     AANDAPVWKTFEMKRGNSYSYNHKDNTIGVWSLDVEEDLVGKTYQYQVQFPHHQTLTR
                     DPYTIATSPDGKRSAILSHVEKQVENFEVKHGSEATWRLENPCKAVICEMHIRDLTKS
                     PTSGVDEHLRGTFLGAAQAGTVNQYGQSTAFDYIKKLGYNYVQLQPIADRHKEYDEDG
                     NVTYNWGYDPQNYNAPETSFSTNPDDPAQVIRDLKVMVQAYHDAGIGVIMDVVYNHTF
                     SVVDAPFQTTVPDYYYRMNPDGTFQNGTGVGNETASEHEMFRKYMIDSLLYWVQEYNI
                     DGFRFDLMGIHDVKTMQMIRQSLDEIDSNIILYGEGWDMGTGLAPYDKAKKDNAYQMP
                     NIGFFNDNQRDAVKGGEVYGAIKSGFVSGAATEPILAKAILGSRELGSYTHPNQVLNY
                     VEAHDNYNLHDLLATLHPDQSSEQIMRKVETATAMNLLMQGMAFMEIGQEFGRTKLVA
                     TGENGELTHDDRERAMNSYNAPDSVNQVNWNLINERQDSIEFIRQVIRLKTKTGAFSY
                     SSYDEIYHHVFVHSAIEHSGCLIYEVHGKEHLLVVVNAKSEPYQFENAGNLAMLVTNS
                     RSKEDNVLNDISLAVLSVL"
     gene            complement(15277..17235)
                     /gene="ligA"
                     /locus_tag="AC0DU4_001298"
     CDS             complement(15277..17235)
                     /gene="ligA"
                     /locus_tag="AC0DU4_001298"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HIN4237257.1"
                     /translation="MNKRMNELVALLNRYATEYYTSDNPSVSDSEYDRLYRELVELET
                     AYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHP
                     TYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLPEELDIT
                     VRGECYMPRASFDQVNQVRQENGEPEFANPRNAAAGTLRQLDTAVVAKRNLATFLYQE
                     ASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVV
                     IKVNDLASQEELGFTVKAPKWAVAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPV
                     QLAGTTVSRATLHNVDYIAEKDIRKDDTVIVYKAGDIIPAVLRVVESKRVSEEKLDIP
                     TNCPSCNSDLLHFEDEVALRCINPRCPAQIMEGLIHFASRDAMNITGLGPSIVEKLFA
                     ANLVKDVADIYRLQEEDFLLLEGVKEKSAAKLYQAIQASKENSAEKLLFGLGIRHVGS
                     KVSQLLLQYFHSIENLSQADSEEVASIESLGGVIAKSLQTYFATEGSEILLRELKETG
                     VNLDYKGQTVVADAALSGLTVVLTGKLERLKRSEVKSKLESLGAKVTGSISKKTDLVV
                     VGADAGSKLQKAQELGIQVRDEAWLESL"
BASE COUNT         5180 a         3796 c         3096 g         5218 t
ORIGIN      
        1 atagcttctg aatttggctg tcatccaact accatccact atacgctcaa agctatgggc
       61 tacactcgaa aaaaagaacc acacctacta tgaacaagac ccagaaaaag tagccttatt
      121 tcttaagaat tttaatagtt taaagcacct agcacctgtt tagattgacg aaacaggatt
      181 cgatacttat ttttatcgaa aatatggtcg ctcattaaaa ggtcagttaa taagaggtaa
      241 agtatctgga agaagatatc agaggatttc tttggttgca ggtctaacaa atggtgagtt
      301 aatcgttcca atgacttacg aagagacgat gacgagcgac ttttttgaag cttggtttca
      361 gaagtttttc ttaccaacat taaccacacc atcggttatt attatggata atgcaagatt
      421 ccatagaatg ggtaagttag aactcttgtg tgaagagttt gggtataaac ttttacctct
      481 tcctccctac tcacctgagt acaatcctat tgagaaaaca tgggctcata tcaaaaagca
      541 cctcaaaaag gtattaccaa gttgcaatac cttttatgag gctcttttgt cttgttcttg
      601 tttcaattga ctatataaat tgtctaagcg aaacaaccga taagaattgg cacaaaagcg
      661 accgtgtttt tgttaccaat acaggaaaaa cagttcatag ttctatcttg agcaagtctc
      721 tccagcgagc aaacgaacgc cttaaaaaac caattcccaa acatctgtcc cctcacatct
      781 tcagacacac cactattagc atcttatcag aaaataaaat tcctttaaaa acaatcacgg
      841 acagggttgg tcattccgac tctgaagtca ctacttccat ctacacccac gtcacaaaga
      901 acatgaaaga tgaagcaatc aatgtactgg ataaagttat gaaaaagatt ttttaaaaag
      961 ttttgcccct tttttgtcct ctaaatacaa aaatagccct tcggataaaa tccgaggggc
     1021 tagaaacgtt gttaaatcaa cggccgaact tttgaatttc atggttcggg ataaaatagt
     1081 tcactgaact attttatttt ttaaggttgt agaatgattt caatccacga tattcagcta
     1141 cttcaccaag ttggtcttcg atacgaagca attggttgta tttagcgata cggtctgtac
     1201 gtgaaagtga accagtcttg atttgtcctg cgttagttgc aactgcaata tcagcgattg
     1261 ttgaatcttc agtttcacct gaacggtgtg atacaacagc agtgtaacca gcttctttag
     1321 ccatttcgat agcttcaaaa gtttcagtaa gagtaccgat ttggttaact ttgataagga
     1381 ttgagttagc agcaccttct tggataccac gtgcaaggta gtcagtgttt gttacgaaga
     1441 agtcgtcacc aacaagttgt actttcttac caagacgttc agtaagagct ttccaaccat
     1501 cccagtcgtt ttcatccata ccatcttcaa tagtgatgat tgggtatttg ttaaccaatt
     1561 cttcaaggta gtcgatttgt tctgcagatg tacgaacagc agcaccttca ccttcaaatt
     1621 tagtgtagtc gtaaacttta cgttctttat cgtagaattc tgatgaagca cagtcaaatc
     1681 cgataaatac gtctttacct ggtacatatc cagcagcttc aatcgcagca aggatagttt
     1741 caacaccatc ttcagttcct tcgaaacgag gagcgaatcc accttcgtca cctacggcag
     1801 tttccaaacc acgtgattta aggattttct taagagcgtg gaagatttca gcaccgtaac
     1861 gaagggcttc tttaaatgtt ggcgcaccaa ctggcaagat catgaactct tggaaagcga
     1921 ttggagcgtc agagtgagaa ccaccgttga tgatgttcat cattggagtt ggaagaactt
     1981 tagtgttgaa tccaccaagg tagctgtaaa gtgggatttc aaggtagtca gcagcagcac
     2041 gagctacagc gatagacaca ccgaggattg cattcgcacc caatttacct ttgttaggag
     2101 taccgtcaag tgcgatcata gcacggtcaa tagcttgttg atcacgtaca tcgtagccaa
     2161 tgatagcttc agcaatgatg ttgtttacgt tgtcaacagc tttttgtgta ccaagaccac
     2221 cgtaacgaga tttgtcaccg tcgcgaagtt caactgcttc gtgttcacca gtagaagctc
     2281 ctgatggaac cataccacgt ccgaaagcac ctgattcagt gtaaacttct acttcaagtg
     2341 ttgggttacc gcgtgagtct aggacttcgc gagcgtaaac atcagtaata attgacattt
     2401 tttactctcc ttatgagtta aattttttac acctctataa taccttaaaa cccctccttt
     2461 ttcaagaaaa aacgttatct ttgtgcaact tttccttaac tttataaagt aatcgctttc
     2521 ttttgtctgt tttattctaa cttttatgat atactgtttt catgacagat ttatcaaaac
     2581 aattacttga aaaagctcat ggtgggttaa aaataaatcc ggatgaacaa agacgctatc
     2641 ttggtacttt tgaggaaaga gttcttggat atgtagatat tgacacagca aatagccctc
     2701 agttagaaaa aggcttttta tttattttag aaaaccttca ggaaaaagca gagccactat
     2761 ttgtgaagat ttcaccaact atcgaatttg ataagcaagt tttctactta aaagaagcaa
     2821 aagaaactga tagtcaagcc accatagtat ctgaagagca tattacttct ccttttggcc
     2881 tggttattca tagcaatgca ccagttcaag tagaagaaaa agaccttcga cttgcttttc
     2941 caaaactttg ggaagttaaa aaggaagaac cagccaaaac atccttatgg aagaaatggt
     3001 ttagctaaat cttgcacata tttaataagt gcccaatatt ggcagccgtg cgctccagat
     3061 agagactggc atttttcaaa ctatcttcta aaggttcact tttctccaaa atagaaaaga
     3121 cagcttggat attttcaaat ggtaggggag gtaaatcttc agcaagacta ccgcaaatag
     3181 caataacagg aactccaaca ggggttcttt ttgcaacacc tataggcgct ttcccagcaa
     3241 agctttgact atcaagtctt ccttctccaa caacaaccaa gtcagcatct gaaactttct
     3301 tatcaaagtt gattaagtcc aagcaggtat caattccaga cacgatactt gcctgagcaa
     3361 aggcacacaa accaccagca aggcctccac ctgctcctgc tcctttaatt tctaatgttg
     3421 caggtgagaa tttttcataa aaatcttgga tcgcctgatc tacgactgca aacatagtcg
     3481 gatgtagacc tttttgattg ccaaaagtgt aagtcgcacc ttgatgacca cataagggac
     3541 tcacgacatc tgctagaata tgaatttgaa caccttcagg aattttatag caattttctg
     3601 ttgaaacaga agctaagttt aataaggatt gatcggaagc aggcaagaca tttccatccc
     3661 tatcataaaa ttgataacct aaaccagcag caatccccag tcctccatca ttactggccg
     3721 tgccaccaac accgatataa atatctttaa tccctttaga aatgagatgg agaatcaact
     3781 ctccaatacc acaagtttgg atttgaagtg gatttcgttt ctctagcgga atttttccaa
     3841 gaccaaccaa gtcagctact tcaaatagtg ccagttcccc tttttgaaaa tagcgcatgg
     3901 cttctttttg tccaaaaggg tctgtcactt ggatccattt ttcttttagg tcaagagaat
     3961 gtcggatagc atctacagta ccttctcccc catcaccagc agggcagagg agacattcta
     4021 catctgctat cgattgttgg aagcctcttt ttattgcttc agctacctgt tgagctgtca
     4081 agctttcctt aaacgaatcc ggtgcaatta caatcttcat attttccctc attctaaaca
     4141 gtcaatcaaa ggaagaactt ctaaaaaatc cctcttgtca acatgatgtg gtatttcttt
     4201 tttgagcatt tctttggaac aaaaggcgat tcctaactcc gccgacttca acattaatag
     4261 attattgacc ccatcaccga ttgccaccgt tctttcttta gaaagtttta gtttctttct
     4321 ccatttttcc agagtttctt ttttgacctg gggacttata atttgtccaa ctaattttcc
     4381 tgttaaaaga ccttctttga cttcaagctg gttggcagtg aaataggcaa taccaaggga
     4441 ttttgctaat ctctccaact attggtgtaa atccaccaga caccagacca actaggatgc
     4501 cattcttttg gagaatagag atgaactctg ggacatttag cgatagatga attgagttga
     4561 agacgttatc aaagaccaaa ataggaagac cttccaacaa ggacactctt tttcttaaac
     4621 tgctttcaaa gaccaactct cctcgcattg ctcgacttgt aatctgcgaa atttccgcct
     4681 catgacctgc ctctctccct aaaagatcaa tcacttcttc taggattaag gttccatcta
     4741 catccaaaac acacaagcct tttacttgag acatcagttc tcctctctaa acagcctaaa
     4801 aatcgtatga agtcatcata cgattttatc tattaattaa ctaaactatg gtacaagtca
     4861 aggtatgact tgcaggctgt atcccatgag aagtcactct ccatagcttg tttttgtagg
     4921 tttctccaaa tgtctggatg gtttctatac aagtccaatg ctgtttggaa agtccaattt
     4981 aaccaataag gagatagatt gtcaaagcta aagccagtac cgcttccttc gattggattg
     5041 aaagcgcgaa ctgtatctcg caagcctcca acttcatgga ccaatggcaa ggttccataa
     5101 cgcatagcca tcatttgaga caagccacac ggttcaaaac gacttggcat gaggaagagg
     5161 tcacaagcag cgtagatttc ctgagcaagt ttgacatcaa aagtgatatt tgttgatagc
     5221 ttgtctgggt aaatctgagc caaccatgag aaagctcctt caaaggctgg atcgccagtt
     5281 cccaaaagaa caatctgaac atcttcttgc aagatatggt gaagactttc gaccaccaca
     5341 tcaaaacctt tttgacgtgt caaacgagaa acaattccca ccagtggaac gtctgctcta
     5401 acaggcaagc caactctttc ttgcaatttt gccttatttt tggctttccc agacaaatct
     5461 tcctgattga aatgatagtc taaaagagca tccgtctgag gattataaag atcagcatca
     5521 atcccattca cgataccaga tactttacca gactccattt taagaatctg atccaaatta
     5581 catccaaact gactagtcat aatttcatga gcatagctag gtgaaacggt tgaaacacgg
     5641 ttcgcataga gaatacctgc cttcatccag ttcagacagt tgttccatcg aagggtgcca
     5701 tcagcgtaac gttcaaggcc aactccaaac aaatcaccca acattccttc tgaaaattgt
     5761 ccttggaatt ctaaattatg aatggttaaa actgtttcaa tgtcctcata ggcttgaatc
     5821 caacggtatt tttccttcaa caagaaagga atcatagctg tatggtagtc atgaatatgg
     5881 agaagatcag gaataaagtc aatcctttcc atagcctcaa tggcagccag ttggaaaaag
     5941 gcaaagcgtt ctccgtcatc aaaatcaccg taaacatgac cacggaagaa ataatattga
     6001 ttgtcaataa agtagaaggt tacaccattt aatactgttt tcttaattcc acaatactgt
     6061 ctgcgccaac caacgctcac ctcaaaatga agcacatctt caatctgatt tccaaattta
     6121 gcctctacca tatcatagta gggtaaaatc actgcaactt cgtgcccagc ttttaccagt
     6181 gattttggaa gagcgccaat gacgtctccc aaaccacctg tttttgaaaa gggtgcaccc
     6241 tctgctgcta caaataaaat tttcatgaat gaatatcctc tgttacttta gcacctttct
     6301 taaccacaac tggatgttct gcagttcctc gaatcacaac accaggctca acttcaaccc
     6361 ctttgtccaa gatagcatat tcgacctgag ccccttctcc aataacaaca cgagggaaga
     6421 gcaggctatc tttaaccaag ctatccttat ggacatgaat attacgtgat agaacagaat
     6481 tagctacttg accttcaata atactaccag aggcaaactg agaagtgctt accttagatg
     6541 tattagcata gtaagttggc tcttcgtttt tgacctttgt ataaatcttt tggtttggtg
     6601 agaaaagaga atagaatttt tgtgattcaa gcatatcgat attcgcttga taataagatt
     6661 taacagagtg aatattggct agatagcccg tgtactcgta ggcgaaagct ccctctttta
     6721 cagccaaatc ccgtaaaaca tagcgcaatt tctttggatg ttctttttta gcttcttctt
     6781 ccaagtgttc aatcaaccaa ggtgtatcaa cgacaaagat atctgtagac atattgaacg
     6841 tttcagctgt tgacttgcta tcaaagagtt tatgagaaag aacatggtct gtttcatcta
     6901 catccaagat tgcatttact tctgaaatat ctttcttagc tagtttttta taaactacag
     6961 tgataggctc ttttgttgta ctatgtaggt ggaaaacttg gttcaaatca atgttaataa
     7021 gaacatcgca gttgagggca accgtttggt ttgagccaga acgtttcaaa taagtaagaa
     7081 gctgttggta gtattctttt ccaactgtac tactttctac acgggtattg taaattccta
     7141 gatagtaatg actaagaagg gttgataagc cccactcgcg tcctgaacga atatggtcaa
     7201 atactgagct gatattatcc tgctggaaaa taccaaagac actacgaaca cctgcattag
     7261 caaggcttga aagtgggaag tcaatcaaac gatatttccc accaaatggc aaacttgcta
     7321 ctggacggtg gtccgtcaat gtcgacatat tgtgaaaacc aactgtattt cctaaaatgg
     7381 cagaatattt atcaatcttc atctgttgct acccccacta cttcattata tcctacaact
     7441 tgtacttcat ctgttccatc aatttcgaca ccgtcagaaa taatcgcacc ttcaccaata
     7501 atggcacgtt taatcttagc tccttgacca atgatagctc cactcatgat aactgaatca
     7561 aggacttccg ctccttcgcg aacttgcgcg cctgttgaaa ggatagaatg tttaacagtt
     7621 ccatcaacga aacatccgtc tacaactaat gagtcttcca catgagcatt tgccccgagg
     7681 aagtttggtg gtgaaatcaa gtttcttgag taaatcttcc attgacggtt acgactatcc
     7741 aaggcatttt ctggagaaat atactccatg ttcgcttccc aaagtgactc aatagtacca
     7801 acatctttcc aataaccact aaattcgtaa gcataaacac tttcacctga ctcaaggtaa
     7861 tttggaatga catttttccc aaagtctgac atgccaacct tgctcttttc agcagcgact
     7921 aacatattac gaaggcgttg ccaatcaaaa atgtagattc ccatagaagc ttttgtagat
     7981 ttaggttgag ctggtttttc ttcaaattca acaatacgat tgttagcatc tgtgttcatg
     8041 ataccaaaac ggcttgcttc tttaagaggg acgtctaaaa ctgctactgt caagctggca
     8101 ttattatcct tatgagactg gagcatatca tcatagtcca ttttgtagat gtgatcccca
     8161 gacaaaatca agacatactc aggattgaca ctgtcgatat agtcgatatt ttggtaaata
     8221 gcgtgactag tcccctcaaa ccaacgattt ccttcacttg cagaataagg ttgaagaata
     8281 gagacacctg aattgatacc gtctagtccc cagcttgaac cattcccaat atggttgttg
     8341 agagcaagtg gttgatactg tgtaacgacc ccaacattat gaatccctga gttggcacag
     8401 tttgataggg caaagtcaat gatacggtag cgcccaccaa attgcacagc tggttttgcg
     8461 atgctttgag tgagtttacc gagacgagtt ccttgcccac cagcaagaat caaagctaac
     8521 atttcatttt tcattttcta ctcctttttg gtttttattt gtgacggttt tagtagattt
     8581 caagcgacgt ttgattttcc atacacttgc tcccatagcc ggtagagtaa aggttaaggt
     8641 ctgctcataa tctttccata gtccttcttg cgtttgaaca gtttgattat gttctttcca
     8701 aacgcctccc cactcttcca actcagtatt ccatacttct tcgtaaattc ctgcaacggg
     8761 tagtccgatt gtaaaatctt tccgctcaac aggtaccatg ttaaagatac agattaacat
     8821 ttctcccttt ttacccttac gaataaagga aagaacactc tggtctcgat tatccgcatc
     8881 aatgatttca ataccatcat agctggtatc gatttcccac agacagcgat gatctttgta
     8941 aaactggttt agctgagaag tgaaatactt catcttagca ttcattgggt cttctaggtt
     9001 agaccattcc aactgttctt cagatttcca ttctaggaat tgaccgtatt cgctacccat
     9061 gaagagcaat ttcttaccag ggtgacaaat ttggtacgta tagagattgc gcaagcctgc
     9121 gaattgattg taacgatctc cccacatctt atgcatcata ctcttcttgc catgaaccac
     9181 ttcatcgtgc gagaatggca agagataatt ctccttgaaa acatacataa agctgaaagt
     9241 caccaggtta aagtcatatt tacgatagat cggatcttct tcgtagaaac ggaggatatc
     9301 attcatccag cccatgttcc atttgtagtc aaatcctaga ccaccaatct ctttcattcc
     9361 cgtaatcttg gtcgcagacg aactttcttc tgcaatcatc atcacatttg gatattctaa
     9421 cttaataacc tcattcaagc gctgaaggaa ataataacct tcatagttga gatttccgcc
     9481 atctttatta ggtgtccatg gagcatcatc atagtccaaa tagagcatgt tgctaacagc
     9541 atccacacga ataccatcca aatgatagac atcaatccaa tgcttaatgc aagaaattaa
     9601 gaaggactgg acttcatttt ttccaaggtc aaaattaagg gcaccccaac catggttatg
     9661 agccttatta tggtcttggt attcaaaagt cggtgtccca tcataatagg ctaaggcatc
     9721 atcgttgatg gtaaagtgac ctggtaccca gtccacaata accccaatat tatgggtatg
     9781 acactcctcg acaaaatctt gaaactcctc tggtcggcca taagcatgct ctaaagcgaa
     9841 gtaacccata agctgatacc cccaactcaa gcccaaagga tgggacatca agggcataaa
     9901 ctcaatatga gtatagttca tttcaacgag ataaggaatg agttcatcct tgagctgggc
     9961 aaaactataa ggactgccat cagaatttct tttccatgat ccagcgtgaa cttcataaat
    10021 attgacagga cgctcttcaa agccccaacg ttttcttcgt gccagccaaa gtccatcctt
    10081 ccatttcttc tcaggaagct ctgttaagat tgcccctgtt cctggacgag cctcatacct
    10141 gacagcaaaa gggtcaatct tcatcagttg atgaccattt tgacgtgtga catgatattt
    10201 gtaaatatgc ccttcttgag ccatattggt aaagacttcc cagaccccaa aatcatttct
    10261 taccattgga atctgatttt caatccagtt ggtaaaatca ccaaccaagt gaacagcctg
    10321 agcattaggt gcccaaacac ggaaggtata gccatgctct ccatttagtt cttccctatg
    10381 tgctcctaga taatgttgga gataaaaatt ttcacccgtc ataaaggttt ttaatgcttc
    10441 tctattatcc atatactccc cttctcctgt aagcgttttc tatgttttta ttatactacc
    10501 tttttagaga agattcaagt aaattactat acttctttaa ttattttgaa aatctacaac
    10561 aagttcactt actcgttcaa ttgtaaatca atattttttc aaaaaattgc gaaaacgcct
    10621 ttctttttct actatagtga aatgaaataa aacatgcgca aatcgattaa ggactttaat
    10681 ctaatttcta acaatgtctt agaaatcaaa gtgtactatt ttaactccaa tgtattatat
    10741 atagtaaaat gaaataataa caggaaaaat cgatttctaa caatatttta gaagtagagc
    10801 tgtactattc tagtttcaat atactataat accaaaaagt tcgtattttt tctataatta
    10861 ttattatttt atagcaaaaa aataaaacca ggaaaacaat ttcctgattt tacacgttat
    10921 ttcacatcaa aaacaatgga tttgacattt gtcatcgctt caatgctata tttaattcct
    10981 tgcactccag ctccagaacc tttgacacca aggaatggga aattatctgg accacgctgg
    11041 gttttattat taatgtggac tgtacctact tcaagttttt cagcaatttc aaaggctttt
    11101 ttgaaatcat ttgtaaagac tgatgattga aggccgaatt cagattcgtt ggcaaaggca
    11161 atagcttcct ctacactagc cacacgaatg attggtaaaa caggaccaaa tggctcttcc
    11221 catgtcactt tcatatcttt tgtaacttgg tcaaaaagca ctggccagag gagattgccc
    11281 tcacgtttga ttggtgtaag agcctgagcc tctttttctt gtgcatcctc aatcaagccc
    11341 caaatgaagt cggctgaagc attgtcaata acaggtgtaa tatcagcatt gtcaaatgga
    11401 tcaccaactg ttaatttaga aacttcttcc tgaagcaaag tagctaattt atctgctaca
    11461 ctttcgagaa caatgacacg tttaatggcc gtgcaacgtt gtcctgagta gctaaaggct
    11521 cccgcaacaa tttgcttggc agcatgttcc aaatctgcat cttctagtac aagagctgca
    11581 tctttcccac caagttccaa catgatagga cgcataccag ctaaacgacc aatacgttct
    11641 ccaataggag ttgaacctgt aaagttgatg aagttgactt ctttgtgctc aatgatataa
    11701 tccccaattt ctgaaccacg acctgtaatg gtgttgaaaa cacctgccgg aatccctgct
    11761 tcttcaaatg ctttagccaa caagagtcca gaaatggaac cttgtgttgg tggcttcaac
    11821 atgaccacat tccctgcaat caaggcaggt gcaattttag aagcagataa attaactgga
    11881 taattaaagg gagcaatcgc tagcacgata ccaactggtt cacgacggac aacagccagt
    11941 ttgtttttac ttgctgcctc aaaaccacca ccttccattg cttgtccagt gatacggaga
    12001 ccttcctcag cagcataacg aatcaagtct gctgtacgca ctacttctcc aattgctgct
    12061 ttaatccctt ttgctacttc tttggcaagg atagtaccaa ttttttcctt atcgcgttct
    12121 aaaatagctg ctgttttatg caaataagcc gcacgttcaa ttgctgataa agctcgccat
    12181 gctggcaggg ctgcacgcgc agcttgcata gcctcatcag cttcagtctg agtcatggct
    12241 ggaactgtac ccaattcttc ttgattgatt ggtgaataaa tcgtaatttc ttgttcagat
    12301 gatttccatt ttccatttac taaattctga tatcttgtca aattcttgtc ctcctgaaaa
    12361 tgattaagat atattttacc aaattttcag aaaatcacaa ccctttttgc aaaatttttg
    12421 agattatttt cacaatcttg atttttcaaa gtatactcaa taaaaattaa aaaaatccac
    12481 tacgtcaagg cgaggctaat gtggtttgaa gaaattttcg aagagcgtga atgagtatca
    12541 tctatagtaa aataaaaaaa ctgaacaatt tggttgggga cagccaaacc aatttctcac
    12601 aatgtttcag aaacaagggt gtgctattcc aatttcagcc tactataact gtcatagatt
    12661 gctgaaacaa agtctaggta aaagtcttca taataaaaag acctcctatc aagtgttcaa
    12721 aaactttgat aggaggtctt gttttgtgaa aatatttatc aaattttcta tacaagtgag
    12781 ctgttagcca ggttctttct attctttcaa tttcaatgaa tggatttttt actaatactc
    12841 ataactggga atttgtctgt gtaaaaatag cgagatagat ggtatttata aaacactcaa
    12901 gacagctaga ctaatatcat ttaaaacatt atcttctttt gagcgactgt tggttaccaa
    12961 catagctaaa tttcctgcat tttcaaattg atagggttct gatttagcat tcacaactac
    13021 caagaggtgt tctttgccgt gaacttcata gataaggcag ccgctatgtt caatcgcaga
    13081 atgcacaaag acatgatggt aaatttcatc atagctagag taagaaaagg caccagtttt
    13141 tgtcttcaat cggatgactt gacggataaa ctcaatactg tcttgacgct cattaatcaa
    13201 gttccagttc acttggttca cactgtcagg agcattatag ctattcatcg cacgctctct
    13261 atcatcatgg gtcaactcac cattttcacc agtcgcaacc agtttggtac gaccaaattc
    13321 ttgaccgatt tccataaagg ccatcccctg catgagcaga ttcatggctg tggcagtttc
    13381 gaccttgcgc atgatttgct ctgaactttg gtctggatga agggttgcca ataaatcgtg
    13441 aagattgtaa ttgtcatggg cttctacata gttaagcacc tgatttggat gtgtatagct
    13501 tcctaattca cgacttccta ggattgcttt agctagaatt ggctctgtcg cagcaccact
    13561 gacaaaacct gacttgatag caccataaac ttctccccct ttgacagcat cgcgctgatt
    13621 gtcattaaag aaaccaatat ttggcatctg gtaggcattg tccttcttgg ccttatcata
    13681 aggggcaaga cctgttccca tatcccatcc ttctccatag aggataatgt tggagtcgat
    13741 ttcatccaag ctttgacgaa tcatctgcat ggtcttgaca tcatgaatcc ccatcaagtc
    13801 aaaacggaag ccgtcaatat tatattcctg cacccagtat agaagagaat caatcatata
    13861 cttgcgaaac atttcgtgtt cactggctgt ttcatttcca acacccgttc cattctggaa
    13921 ggtaccatct ggattcatac gataatagta atcagggact gttgtttgga atggtgcatc
    13981 aacaactgag aaggtatggt tatagactac atccataatg actccaatac ccgcatcgtg
    14041 ataagcttga accatcacct tcaaatcacg aatgacctga gctggatcat ctggattagt
    14101 tgaaaaacta gtttctggcg cgttatagtt ttgtggatca taaccccagt tgtaggttac
    14161 atttccatcc tcatcgtatt ctttatgacg gtctgcaatt ggttgcaatt gaacataatt
    14221 gtagcccagc ttcttgatgt aatcaaaagc agttgactgg ccgtattggt taactgttcc
    14281 agcctgagca gcacccaaga aagttcctcg aagatgttca tctacacccg atgtaggtga
    14341 tttagtcaaa tcacgaatgt gcatttcaca gataactgcc ttacatggat tttccaagcg
    14401 ccaagtagcc tccgaaccgt gcttaacctc gaagttttca acttgctttt ctacatggct
    14461 cagaatagct gaacgtttgc catcagggct ggtcgcgatt gtataaggat cacgtgtcag
    14521 tgtttggtga tgagggaatt ggacttgata ctgataagtc ttacctacca aatcttcttc
    14581 aacatccaaa ctccagacac cgattgtatt gtccttatga ttataagagt agctattgcc
    14641 tcttttcatc tcaaaagtct tccaaacggg tgcatcatta gcagctgatt cataaacgac
    14701 aacttgcact tctgtcgctg taggtgacca gagagaaaaa tgagcctgat tgtcctctac
    14761 acggcaaccc aattctcctt ggtaacccca atgatgatca aaactagcac tgttaatggc
    14821 cttatcaaag gcaaaaggat tttgattttt atagaaagga ctggcaatag caggattttc
    14881 agagtaataa atcctatcat cgccttccaa aatccagacc tctgttaata ggggatagtg
    14941 attaaaacgg atagaatatt ctttactagt ttgacctgta tgaaccacaa aattcaagct
    15001 ttctataaca tgtgaacttg ggtgttcaaa gctaaataaa gctccaaaat aatcttcttt
    15061 gtaggttagc aaatcaattc gttgatcctg actttttaca aaggagcaag tgtcatattc
    15121 tccattctta cgatggtaat gaatgcgcat agggtagtta tacatttttt atttttcctt
    15181 tttactttgt ttctatttca ctaataaatt tttgtcaatc tcgtctcaat taacagacat
    15241 agtcatattc tctaaactct gtttttaaac gatccattac aaactttcta gccatgcctc
    15301 atctctgacc tggataccaa gttcttgtgc tttttgcagt ttacttccag cgtctgcacc
    15361 taccacgacg aggtcggtct ttttagaaat actacctgtc actttggcac ccagactttc
    15421 gagtttactt ttaacttctg agcgcttgag tcgttccaat tttcctgtca ataccacggt
    15481 caaacctgac aaggccgcat ccgctactac cgtctgtcct ttatagtcca gattgacccc
    15541 agtttctttc aattctctga gcagaatttc agagccttct gtcgcaaaat aagtctgaag
    15601 acttttggca atcacgccac ctagactttc aatactagcc acttcctctg aatctgcctg
    15661 agacagattt tcaattgaat ggaaatattg aagtaaaagc tgactaacct tgcttccgac
    15721 atgacgaatt cccaaaccaa ataagagctt ctcggcagag ttttcctttg atgcttggat
    15781 agcctgatac agtttagcag cggacttttc cttaaccccc tctaaaagga ggaaatcctc
    15841 ttcttgcaaa cgataaatat ccgccacatc cttgactaaa ttagcagcaa aaagcttctc
    15901 aacaatagat ggaccaaggc ctgtaatatt catagcatca cgagaagcaa agtgaatcaa
    15961 gccttccatg atttgagcag ggcaacgcgg attgatacaa cgtagggcca cttcatcttc
    16021 aaagtgcaac aagtcagagt tacaacttgg acagtttgta gggatatcta gtttttcttc
    16081 agaaacccgt ttggactcta ccacacgtaa aacggcaggg atgatgtcac cagccttata
    16141 tacaatgacc gtatcgtctt ttcggatatc tttttcagca atataatcta cattgtgcag
    16201 ggtcgcacgg ctaacagtcg taccggcaag ttgtactggt gttagattag cagttggagt
    16261 tacaacaccg gtacggccaa ctgtccagtc aactgataag agttgagctt ctttttcttc
    16321 ggcagggaac ttgtaggcta ctgcccactt tggagcctta acggtaaaac caagttcttc
    16381 ttgacttgct aggtcgttga ccttgattac cactccatca atatcgtaag gcagattttc
    16441 ccgttcctgt cctacttctt ggataaaatt ccagatttca tctatgtttt cagccaagat
    16501 tcgcttagga ttgaccacaa aacctagttg ttctaggtac ttcaaaccct tttcttggct
    16561 atcacgagtt gaagggctgg cttcttgata gagaaacgtt gcaagattac gcttggcaac
    16621 tactgctgta tccaactgac gcagagttcc tgctgccgca ttacgaggat tagcaaattc
    16681 aggctctcca ttttcttggc gcacttggtt aacttggtca aaggaagcgc gtggcatgta
    16741 acattcccca cgaactgtga tatctagttc ttctggcaaa gtcaaaggga tgtccttaac
    16801 acgcttgagg ttttctgtga tattttcacc aattgaacca tctccacgtg ttaccccagc
    16861 aaccaaaatc cccttttcat aagtcagcga gatagataag ccatcgattt tcagctcaca
    16921 aatataggtc ggatgagcca cttccttacg aacacgcgca tcaaaagcat ctagctcctc
    16981 acgtgaaaaa gcatcctgca aactataaag aggatactga tgactgtatt tttcaaaacc
    17041 atctaaaacc ttgccaccaa cacgatgagt cggactgtct gctagcactt gctctggata
    17101 agcagtttct aactcgacca actcacggta aaggcggtca tactcactgt ctgaaaccga
    17161 gggattatcg ctggtatagt actcagtcgc atagcgattg agcaaagcga ctaactcatt
    17221 cattctttta ttcataagac cattttacca taaaacaagc cctcctcaca aacgagaagg
    17281 gcggaaaaaa
//
LOCUS       DBMVGT010000035        17094 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.035, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000035 DBMVGT010000000
VERSION     DBMVGT010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 17094)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17094)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17094
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.035"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1100)
                     /gene="phtB"
                     /locus_tag="AC0DU4_001299"
     CDS             complement(<1..1100)
                     /gene="phtB"
                     /locus_tag="AC0DU4_001299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtB"
                     /protein_id="HIN4237258.1"
                     /translation="MKINKKYLAGSVAVLALSVCSYELGRYQAGQDKKESNRVAYIDG
                     DQAGQKAENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISE
                     ELLMKDPNYQLKDSDIVNEIKGGYVLKVNGKYYVYLKDAAHADNIRTKEEIKRQKQER
                     SHNHNSRADNAVAAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNEL
                     SASELAAAQAYWNGKQGSRPSSSSSYNANTAQPRLSENHNLTVTPTYHQNQGENISSL
                     LRELYAKPLSERHVESDGLIFDPAQITSRTARGVAVPHGNHYHFIPYEQMSELEKRIA
                     RIIPLRYRSNHWVPDSRPEQPSPQSTPEPSPSL"
     gene            complement(1108..2025)
                     /gene="adcAII"
                     /locus_tag="AC0DU4_001300"
     CDS             complement(1108..2025)
                     /gene="adcAII"
                     /locus_tag="AC0DU4_001300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding lipoprotein AdcAII"
                     /protein_id="HIN4237259.1"
                     /translation="MKKQNLFLVLLSVFLLCLGACGQKESQTGKGMKIVTSFYPIYAM
                     VKEVSGDLNDVRMIQSSSGIHSFEPSANDIAAIYDADVFVYHSHTLESWAGSLDPNLK
                     KSKVKVLEASEGMTLERVPGLEDVEAGDGVDEKTLYDPHTWLDPEKAGEEAQIIADKL
                     SEVDSEHKETYQKNAQAFIKKAQELTKKFQPKFEKATQKTFVTQHTAFSYLAKRFGLN
                     QLGIAGISPEQEPSPRQLAEIQEFVKTYKVKTIFTESNASSKVAETLVKSTGVGLKTL
                     NPLEADPQNDKTYLENLEENMSVLAEELK"
     gene            complement(2168..3559)
                     /locus_tag="AC0DU4_001301"
     CDS             complement(2168..3559)
                     /locus_tag="AC0DU4_001301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001020339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015171 - amino acid transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="APC family permease"
                     /protein_id="HIN4237260.1"
                     /translation="MNIFRTKNVSLDKTEMHRHLKLWDLILLGIGAMVGTGVFTITGT
                     AAATLAGPALVISIVISALCVGLSALFFAEFASRVPATGGAYSYLYAILGEFPAWLAG
                     WLTMMEFMTAISGVASGWAAYFKGLLSQYGIAFPQALNGTFNPQAGTFVDLLPILVLV
                     LVTSLVLLNAKAALRFNSILVILKFSALALFVLVGIWNIKFDNWSNFAPYGFGQIYGA
                     STGIMAGASLMFFGFLGFESISMAVDEVKTPQKNIPRGIVLSLSIVTILYALVTLVLT
                     GVVHYSHLNVDDAVAFALRSVGISWAANYVSLVAILTLITVCISMTYALSRMIYSLAR
                     DGLVPAAFKELTKTSKVPKNATILTGLASAVAAGMFPLASIAAFLNICTLAYLIMLAY
                     GLIRLRKEKGMPKAGEFKTPLVPLLPILSIIICLSFMLQYNMNTWIAFLVALLVGSII
                     YFTYGYKHSTIEE"
     gene            complement(3933..4490)
                     /gene="sdbB"
                     /locus_tag="AC0DU4_001302"
     CDS             complement(3933..4490)
                     /gene="sdbB"
                     /locus_tag="AC0DU4_001302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     lipoprotein SdbB"
                     /protein_id="HIN4237261.1"
                     /translation="MKKVMFAGLSLLSLVVLMACGEEETKKTQAAQQPKQQTTVQQIS
                     VGKDAPDFTLQSMDGKEVKLSDFKGKKVYLKFWASWCGPCKKSMPELMELAAKPDRDF
                     EILTVIAPGIQGEKTVEQFPQWFQEQGYKDIPVLYDTKATTFQAYQIRSIPTEYLIDS
                     QGKIGKIQFGAISNADAEAAFKEMN"
     gene            complement(4501..5208)
                     /gene="ccdA2"
                     /locus_tag="AC0DU4_001303"
     CDS             complement(4501..5208)
                     /gene="ccdA2"
                     /locus_tag="AC0DU4_001303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004237834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HIN4237262.1"
                     /translation="METIVFLISVFLAGVLSFFSPCIFPLLPVYAGILLDDQESAKSF
                     SLFGRKVLWSGLIRTLCFIAGISLIFFILGFGAGYFGHILYANWFRYVMGAIIIILGL
                     HQMEIFHLKKLEVQKSFTFKKSDFNRYWSAFLLGITFSFGWTPCIGPVLSSVLALAAS
                     GGNGAWQGAIYTLIYTLGMALPFLVLALASGLVMPYFSKIKRHMMLLKKIGGFLIVLM
                     GILLLLGQVNVLAGIFE"
     gene            complement(5439..5843)
                     /locus_tag="AC0DU4_001304"
     CDS             complement(5439..5843)
                     /locus_tag="AC0DU4_001304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000377663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="EGFR-like transmembrane domain-containing
                     protein"
                     /protein_id="HIN4237263.1"
                     /translation="MDSLKDVKANASDSKPAQDKKDAKQGTEDSKDSDKMTETNSVPA
                     GVIVVSLLALLGVIAFWLIRRKKESEIQQLSTELIKVLGQLDAEKADKKVLAKAQNLL
                     QETLDFVKEENGSAETETKLVEELKAILDKLK"
     gene            complement(5885..6085)
                     /locus_tag="AC0DU4_001305"
     CDS             complement(5885..6085)
                     /locus_tag="AC0DU4_001305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000226586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237264.1"
                     /translation="MVASASASSTSTQAQEQVDKSELRALSQELDQRLKALATVSDPK
                     IDATKAVLLDAQKAPEDSALTE"
     gene            complement(6252..6893)
                     /locus_tag="AC0DU4_001306"
                     /pseudo
     CDS             complement(6252..6893)
                     /locus_tag="AC0DU4_001306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 transposase-related protein"
     gene            complement(7107..8870)
                     /locus_tag="AC0DU4_001307"
     CDS             complement(7107..8870)
                     /locus_tag="AC0DU4_001307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphoryl diester phosphodiesterase
                     membrane domain-containing protein"
                     /protein_id="HIN4237265.1"
                     /translation="MKPEKPKKLGLKQIYLNLDKILFLFFLIFMIVEYLWVPFNSWLA
                     SFLLDQTGYLFISYNNVLAILTHSPLISLAFLALIVINLLVAYFQIGLLFIGARHLLY
                     NEKRRLIEYIRKVFHESFGFMKKLTCAKALFIFFYIAMLFPFIRKMLKIYYLNKIVIP
                     EFIQAYLEDRYWMWWLSILLLSLIFLYVSVRLMFALPKIVYDQLTVREAVMFSLEKTK
                     KRVTFYAWNLFYILLKAHLLFYLPLIPLLLAQTLVDDITQRESLILGILNFVVIKNLY
                     YMALTYFLVKFVSFLTGKELDMLPRREKDHIVRWGVMTCASLFFALEGYIYLEAPMVH
                     LPQLISHRGVSNANGIQNTVESLETTAQLKPDLVETDVQETKDGQFVMMHDANLKNLA
                     GINKSPQDLNLEELKGIDIFENGYQTKISSFEDYLSRANELGQKLLIEIKTSKKDSPD
                     MMNRFLARYAAKLKIYGHQIQSLDYHVVEKVRQYDAELPVYFIMPYNSVFPKTRATGY
                     TMEYSTLDEYFVSKLWTTDQKLYVWTVNDSEAISKSLHLGVDGVITDDLEKVQREIEV
                     AQEDPEYTDLLLKKALEFFEF"
     gene            complement(8879..9469)
                     /locus_tag="AC0DU4_001308"
     CDS             complement(8879..9469)
                     /locus_tag="AC0DU4_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HIN4237266.1"
                     /translation="MERLEDYIAFDLEFNQHEGQTHLIQVSAVRFRDGREIDAYDSYV
                     HTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQEFVGSLLMIGYNAAKSDLPILAE
                     HGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTAR
                     VYESFLESDQARELLETESSLSNNPFGGLDLSQLFD"
     gene            complement(9567..10058)
                     /gene="rocS"
                     /locus_tag="AC0DU4_001309"
     CDS             complement(9567..10058)
                     /gene="rocS"
                     /locus_tag="AC0DU4_001309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein RocS"
                     /protein_id="HIN4237267.1"
                     /translation="MSIEMTVSEIAEILGLSRQAINNRVKELPEEDTDKNDKGVTVVT
                     RSGLIKLEEIYKKTIFEDEPVSEDVKQRELMEILVDEKNAEILRLYEQLKAKDRQLSE
                     KDEQMRIKDRQIAEKDKQLDQQQQLTLQAMKDQENLKLELDQAKEEVQSTKKGFFARL
                     FGG"
     gene            complement(10135..10827)
                     /locus_tag="AC0DU4_001310"
     CDS             complement(10135..10827)
                     /locus_tag="AC0DU4_001310"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008782 - adenosylhomocysteine
                     nucleosidase activity [Evidence IEA];
                     GO_function: GO:0008930 - methylthioadenosine nucleosidase
                     activity [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA];
                     GO_process: GO:0009164 - nucleoside catabolic process
                     [Evidence IEA];
                     GO_process: GO:0019509 - L-methionine salvage from
                     methylthioadenosine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HIN4237268.1"
                     /translation="MKIGIIAAMPEELAHLVQHLDNAQEQVVLGNTYHTGTIASHEVV
                     LVESGIGKVMSAMSVAILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDV
                     TAFGYAYGQMAQQPLYFESDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEA
                     IKSHFPEVLAVEMEGAAIAQAAHALNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRS
                     AQVLLAFLKALD"
     gene            complement(10844..11158)
                     /gene="macP"
                     /locus_tag="AC0DU4_001311"
     CDS             complement(10844..11158)
                     /gene="macP"
                     /locus_tag="AC0DU4_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall synthase accessory phosphoprotein
                     MacP"
                     /protein_id="HIN4237269.1"
                     /translation="MGKSLLTDEMIERANRGEKISGPPLLDDNEETKILPTSSSRFGY
                     ANPKDHGFSQETLKIQVEPSIHKSRRIENTKRNVFNSKLNKILFAVIFLLILLVLAMK
                     LL"
     gene            complement(11170..11715)
                     /locus_tag="AC0DU4_001312"
     CDS             complement(11170..11715)
                     /locus_tag="AC0DU4_001312"
                     /EC_number="3.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000393791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016817 - hydrolase activity, acting on
                     acid anhydrides [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0009132 - nucleoside diphosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HIN4237270.1"
                     /translation="MEFEEKTLSRKEIYQGPIFKLVQDQVELPEGKGTAQRDLIFHNG
                     AVCVLAVTDEQKLILVKQYRKAIEAVSYEIPAGKLEVGENTAPVAAALRELEEETAYT
                     GKLELLYDFYSAIGFCNEKLKLYLASDLTKVENPRPQDEDETLEVLEVSLEEAKELIQ
                     SGHICDAKTIMAVQYWELQKK"
     gene            complement(11725..13104)
                     /gene="glmU"
                     /locus_tag="AC0DU4_001313"
     CDS             complement(11725..13104)
                     /gene="glmU"
                     /locus_tag="AC0DU4_001313"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002899862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0003977 - UDP-N-acetylglucosamine
                     diphosphorylase activity [Evidence IEA];
                     GO_function: GO:0019134 - glucosamine-1-phosphate
                     N-acetyltransferase activity [Evidence IEA];
                     GO_process: GO:0006048 - UDP-N-acetylglucosamine
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HIN4237271.1"
                     /translation="MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQ
                     PEKTVTVVGHKAELVEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGD
                     TPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATD
                     FEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLK
                     DFDESLGVNDRVALATAESVMRCRINHKHMVNGVSFVNPEATYIDIDVEIAPEVQIEA
                     NVTLKGQTKIGAETVLTNGTYVVDSTIGAGAVITNSMIEESSVADGVTVGPYAHIRPN
                     SSLGAQVHIGNFVEVKGSSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKY
                     KTVIGDNVFVGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYAT
                     RLPHHPRNQ"
     gene            13238..14038
                     /locus_tag="AC0DU4_001314"
     CDS             13238..14038
                     /locus_tag="AC0DU4_001314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003796 - lysozyme activity [Evidence
                     IEA];
                     GO_process: GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA];
                     GO_process: GO:0016998 - cell wall macromolecule catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GH25 family lysozyme"
                     /protein_id="HIN4237272.1"
                     /translation="MRKQIHPLILFSFLGIMMFILIINRPLNDNQSFKTKSNIAQIEA
                     QALKHLDKPIIDLSGWQHPEEINYDALSQNISGAIVRVHSGAQTTKENDASFINGIDK
                     AYKSHITELQKRNVPVAVYAYVAGKSVQEMEKAAEVFYNAASPYSPSYYWLDVEDKTM
                     SNMNEGVENFRAKLASLGAKNIGIYVGVYFMEEHSIDTGKFTSIWIPSYGSDSGFLES
                     SPKTDLDYDIHQYTSKGKIAGFDHDLDINVISPLKNKEETFRKLFLKP"
     gene            14133..14975
                     /locus_tag="AC0DU4_001315"
     CDS             14133..14975
                     /locus_tag="AC0DU4_001315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF368 domain-containing protein"
                     /protein_id="HIN4237273.1"
                     /translation="MLSWLARVIKGIVIALGFILPGISGGVLAAILGIYERMIGFLAH
                     PFKDLKENVLYFIPVAIGMLLGIGLFSYPIEYLLENYQVFVLWSFAGAIIGTVPSLLK
                     ESTRESDRDKIDLAWLWTTFIISGLGLYSLNFVVGTLSASFLNFVLAGALLALGVLVP
                     GLSPSNLLLILGLYAPMLTGFKTFDLLGTFFPIGIGAGATLIVFSKLMDYALNNYHSR
                     VYHFIIGIVLSSTLLILIPNTGNAESIQYTGLSLVGYVIIAFFFALGIWLGIWMSQLE
                     DKYK"
     gene            14975..15457
                     /locus_tag="AC0DU4_001316"
     CDS             14975..15457
                     /locus_tag="AC0DU4_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA deacylase"
                     /protein_id="HIN4237274.1"
                     /translation="MAKKVKIKKTLVEQILSKAAIPHQGIQINALEGELPQGYERDQI
                     FKTLALLGDKTGPIIGIVPITQHLSEKKLAKISGNKKVSMIPQKDLEKTTGYIHGANN
                     PVGIRQKHNYPIFIDKIALDLDRMIVSAGEVGHSIIVAPQDLASFVKADFVDILEDIK
                     "
     gene            15457..16077
                     /locus_tag="AC0DU4_001317"
     CDS             15457..16077
                     /locus_tag="AC0DU4_001317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HIN4237275.1"
                     /translation="MKLYFVRHGRTLWNQEGRFQGASGDSPLLPESIETLKRLGQYLK
                     EIPFDQIYSSDLPRAVKSAEIIQSQLHTPCSLEIVPNLREWQLGKLEGLKIATLEAIY
                     PQQIQAFRSNLAQFDTRMFGAESLYSTTQRTIQFIKSLKDSPADRILIVGHGANLTAS
                     LRTLLGYKEPLLRKDGGLANASLTIIETHDFETFTLNTWNDTSYQS"
     gene            complement(16330..16425)
                     /locus_tag="AC0DU4_001318"
                     /pseudo
     CDS             complement(16330..16425)
                     /locus_tag="AC0DU4_001318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            16838..17094
                     /locus_tag="AC0DU4_001319"
                     /pseudo
     CDS             16838..17094
                     /locus_tag="AC0DU4_001319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_process: GO:0015074 - DNA integration [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
BASE COUNT         5193 a         3591 c         3035 g         5275 t
ORIGIN      
        1 agacttggac taggttccgg agtcgattgt ggacttggtt gttctggtct tgaatctggt
       61 acccaatggt ttgaacgata acgaagggga ataatacgag caattcgttt ttccaattca
      121 gacatttgtt cataagggat aaagtggtaa tggttaccat gagggacagc tacacctctg
      181 gcggttcgac ttgtgatttg cgctgggtcg aaaataaggc catcagattc cacatggcgt
      241 tctgataagg gtttagcata caattcacgt aaaaggcttg aaatgttttc cccttgattt
      301 tgatgataag ttggagtgac agtcagattg tggttctctg acaatcttgg ttgagctgta
      361 tttgcattat aactagaact tgaagaagga cgagatccct gcttcccatt ccaataggct
      421 tgggcagcag ctaactcgct agctgataac tcattcttag gaatgtaatg gtaatggtcg
      481 ccgtgaggaa cgatataggc atcgcccgta tcttcaatga tatcagatgc attgaagata
      541 tacccatcat ccgttgtata acgtccttgg gctctggctg cagcaacagc attatctgct
      601 cttgagttat gattatgact gcgttcctgc ttctgacgtt taatctcttc ttttgtccga
      661 atattatccg catgagctgc atccttaagg taaacatagt atttaccgtt taccttaagg
      721 acataaccac ccttgatttc attgacaatg tctgaatcct tcaactgata attcggatct
      781 ttcatgagga gctcttcact gatgatggca tcataaggga ccttgccatt atagtaatga
      841 taatggtctc catgagaggt cacataacct tgatccgtaa tcttgatgac gatttgttcg
      901 gcgttgatcc cctccctctt actgacttca tctggtgtca agttttctgc cttttgacca
      961 gcctgatcac catctatata agcaactcga ttagactctt tcttatcctg accagcttgg
     1021 taacgtccaa gctcatagga acaaacactt agggcaagaa ctgccaccga acctgctaga
     1081 tattttttat tgattttcat tctttcctca ctttaattct tctgctagaa cactcatatt
     1141 ttcttccaga ttttctaaat aggtcttgtc attttgtggg tctgcctcta aaggattcag
     1201 agttttaaga cccacacctg ttgatttgac aagagtttca gctacttttg aagaagcatt
     1261 actttctgta aaaatcgttt taaccttata ggttttaaca aattcctgaa tttctgctaa
     1321 ttgtcgtgga cttggttctt gttcaggaga gatgcctgca ataccaagtt gattaagccc
     1381 aaatctcttc gctagataag aaaaggctgt atgttgtgtt acaaatgttt tctgagtcgc
     1441 tttttcaaat tttggttgga atttcttagt caattcctga gcttttttga taaaggcttg
     1501 cgcatttttt tgataagtct ctttatgctc actatccacc tctgaaagtt tatcagcgat
     1561 aatttgggct tcttctccag ctttttcagg atctagccat gtgtgagggt catagagcgt
     1621 tttttcatca actccatccc ctgcttccac atcctctagt ccagggacac gttccaaggt
     1681 cattccctca gaagcctcta agaccttcac tttggatttt tttagattgg gatccagact
     1741 tcctgcccaa gattcgagtg tatgagaatg gtaaacaaag acatctgcat catagatggc
     1801 tgcgatatca tttgccgaag gttcaaagga gtgaatacca ctacttgact gaatcatccg
     1861 aacatcattc aagtcaccag atacttcctt aaccatagcg tagataggat aaaaactggt
     1921 cacaattttc atcccctttc ctgtctgact ttccttttga ccacaagccc ccaagcacaa
     1981 aagaaagaca cttaacagga ctaaaaataa attttgtttc ttcatgaaca actccttaac
     2041 catttaatta actagtaaat attctactcc tgaaaattta atctgtcaag atatttttag
     2101 aaaaaatttg aaatttcttt cacatataaa aatctgctga gtgtcaacaa ctcaatagac
     2161 tttcacttta ttcttctatg gtagaatgct tatagccata agtgaagtaa ataatacttc
     2221 ctactaacaa cgcaactagg aaagcaatcc aggtattcat attatactgt aacatgaagg
     2281 ataaacaaat gatgatcgat aaaattggta acagaggtac caatggtgtt ttaaattccc
     2341 cagctttggg cattcctttt tctttccgta agcgaatcag accataagcc aacatgatca
     2401 agtaggctaa ggtacaaata tttaaaaagg ctgcaatact ggctagtggg aacattcctg
     2461 ctgctactgc tgaagctaga cctgtcaaga tagtagcatt ctttggtacc ttgctagtct
     2521 tcgtcagttc cttaaaggca gcaggcacta agccgtcacg tgctaaactg taaatcatac
     2581 gcgatagggc ataggtcatc gaaatacaaa ctgtaatcaa ggtcaagata gccactaatg
     2641 acacatagtt ggctgcccaa ctaatcccaa cactacgaag ggcaaaggca acggcatcat
     2701 cgacatttaa atgactatag tgaaccacac cagtcaaaac aagggtcacc aaggcataga
     2761 gaatggttac gatagaaagc gataagacaa tccctctagg aatatttttt tgaggagtct
     2821 tgacttcatc tacagccata gagatggatt caaatcccaa aaaaccgaag aacatcaagg
     2881 atgcaccagc cataatacca gtactagctc catagatttg tccaaaaccg taaggagcaa
     2941 aattgctcca attatcaaac ttaatattcc aaattcctac taaaacaaag agagctaaag
     3001 cggaaaattt caaaataact agaatcgaat taaagcgtaa ggctgccttg gcatttagta
     3061 aaacaagcga agtcaccaag accaagacaa gaataggcaa taaatcaaca aatgtccctg
     3121 cttgaggatt aaaggtacca tttaaagcct gaggaaaggc tatcccgtat tgagagagca
     3181 agcctttaaa ataagctgcc caacccgaag ctacgcctga tatggctgtc atgaactcca
     3241 tcatggttaa ccaaccagcc aaccaggcag ggaattctcc taagatagca tagaggtaac
     3301 tataggcacc tcctgtagcg ggtactcgcg aggcaaattc tgcaaaaaag agggctgata
     3361 atcccacaca caaggcagaa ataacgattg aaatcactag ggctgggcca gcaagtgttg
     3421 cagctgcagt acctgtgatt gtaaagacgc ctgtccctac catggctccg atacccagca
     3481 aaatcaaatc ccataacttc aaatgcctat gcatctctgt tttatctaaa ctaacattct
     3541 ttgttctaaa tatattcatc tttgactcca aaataaactg ataattctat tttaccataa
     3601 atataggaga tatgtgaata tttataaaat gtttttctaa aaaaatctga ctaccgtaac
     3661 ttctcaaagt aacttccatc tctctcccaa aactggaagt tactctaaga cgactctgtt
     3721 ttagggctat ttgtcgtgca ctttttctga gtcttttcgc ttttgaaccc ttatatatca
     3781 agaaaaagaa aaccagtgga agttagtcta agacggattt ccactgatgt cacgcgtttt
     3841 tctcatacta aaagctaggt tgtgggaaac tggaagttag ttttagaagt taccaaaatc
     3901 tgactacatc ttgtaatcag attttatcga ttctagttca tttctttaaa tgctgcttct
     3961 gcatccgcat tactgatagc accaaattga atctttccaa tctttccttg gctatcaatt
     4021 aaatattctg taggaatgct tcgaatttga taagcttgga aggtggttgc tttggtatca
     4081 taaagaactg ggatatcctt atatccttgt tcctggaacc attgtgggaa ttgctcaaca
     4141 gttttttcac cttgaattcc tggtgcaatg acagtaagaa tttcgaaatc acgatctggt
     4201 ttcgccgcta gttccatcaa ctctggcata cttttcttgc atggaccaca ccatgaagcc
     4261 caaaacttca agtaaacctt tttaccctta aaatcagata acttaacttc tttgccatcc
     4321 atggattgca atgtaaagtc tggagcatct tttccaacag aaatttgttg tacagtcgtt
     4381 tgttgttttg gctgttgtgc tgcttgagtc tttttagttt cttcctcacc acaggccatc
     4441 aatacaacta atgacaagag acttaagcca gcaaacatta cttttttcat ttgtcctcct
     4501 ttattcaaaa attccagcta gaacatttac ttgtcctaat agtaacaaaa ttcccattaa
     4561 aacaatgagg aaaccaccaa ttttctttag tagcatcata tgacgcttga ttttactaaa
     4621 atatggcatg actagacctg aagctagtgc caagaccaag aaaggaaggg ccatgcccag
     4681 agtgtaaatg agagtataaa tcgctccttg ccaagcacca ttgcctccag aagccgcaag
     4741 tgctaaaaca gaacttaaaa ctggaccaat acaaggtgtc caaccaaagc taaaggtaat
     4801 accaagtaaa aaagctgacc aataacgatt aaaatctgat tttttaaagg taaaactttt
     4861 ttgaacttct aatttcttca aatgaaaaat ttccatctgg tgaagaccca aaatgataat
     4921 aatagctccc atgacatatc gaaaccaatt tgcatagaga atatgaccaa agtaaccagc
     4981 accaaagcct agaataaaga aaatgagaga gataccagcg ataaagcaaa gtgttcgaat
     5041 caagcctgac cagagaacct ttctcccaaa caaagaaaag ctttttgcac tttcttgatc
     5101 atccaataaa atcccagcat agactggcag aagaggaaaa atacaaggag aaaaaaagga
     5161 taaaacacct gctagaaaaa cagagattaa aaatactatc gtttccaata aagaaccaac
     5221 tttcttaata attctaatcc tattttacta tattcaattt tatttgtaag ctttctgcta
     5281 cgcaaaatcg tatcgggcac tattggacca atcttttctt ttgctagtca aggcggatct
     5341 tatcccccaa aatagccaaa aagcaacgac aaggattact catcgctgct tttgtgaacg
     5401 aaaatgtctt ttaggtctga catttcataa atcatgtttt acttgagttt gtcaaggatt
     5461 gctttaagct cctctactag tttagtttct gtctctgctg agccattttc ttctttcacg
     5521 aaatcaaggg tttcttggag aaggttttgg gctttggcaa ggactttttt atccgctttt
     5581 tctgcatcta gctgtcctag aaccttgatc aattccgtgc ttaattgctg gatttctgac
     5641 tctttcttac ggcgaatcag ccagaaggca atcacgccta ggagggcaag tagactgacc
     5701 acaatcactc ctgccggaac tgagtttgtt tcagtcatct tatctgaatc cttactatct
     5761 tccgttcctt gttttgcatc cttcttgtcc tgtgcaggct tgctgtcgct agcatttgct
     5821 ttcacatctt tgagagagtc caaggcagcc cagccttcac agactctact gcagtatgca
     5881 gaccttactc tgtcaaggca ctatcttccg gagctttttg agcatctagg aggacagcct
     5941 tggttgcatc gattttcgga tcagatactg ttgccaaagc tttcaagcgt tggtctaact
     6001 cttgactcaa ggcacgaagt tcagacttgt caacttgctc ttgagcttgt gtgctcgttg
     6061 agctagccga agcgcttgct accactctag gatcttgagt cggagctgag cttggagctg
     6121 ggacagggct tgcaggttga ctaggaacag ttatggtata ttgaaactag aatagtacat
     6181 atggacttct aaaacattgt tagaattcga ttttactgtc ctgatcgatt tgtcctattc
     6241 ttatttcatt ttactataat aaccgatggt gtggttaatg ttggtaagaa aaacttctga
     6301 aaccatactt caaaaaagtc gctcgtcatc atctcttcgt aagtcattgg agcgattaat
     6361 tcaccatttg ttagacctgc aaccaaagaa atcctctgat atcttcttcc agatactttg
     6421 cctcttctta actgaccttt taatgagcga ccatattctc gataaaaata agtatcgaat
     6481 cctgtttcat caatctaaac aggtgctagg tgctttaaac tattaaaatt cttaagaaat
     6541 aaggctactt ttctgggtct tgttcatagt aggtgtggtt ctttttttcg agtgtagccc
     6601 atagctttga acgcatagtg gatggtagtt ggatgacagc caaattcaga agctatttca
     6661 gtcaaataag cgtctggatt gtcagtaaga tagtttttaa gtctatctct atcaactttt
     6721 cttggttttg ttccttttac ttggtggttt aactctcctg ttttcttttt tagctttaac
     6781 cagccataaa tggtattacg tgagatttgg aaaacgtgtg atgcttctgt tatactacct
     6841 attcgctcac aataagagag aactttttta cgaaaatcta ttgaatatgc cataagaaga
     6901 ttataccaca ttgtgtacta tttttggttc attttactat attttataag ttatagtgta
     6961 gcattccaac ttcaaagcac tataaagtaa attgaaacaa gaacaataca aacaattctc
     7021 gtaaacggat tgcaaccaca aaaaagcaag cattcacaag aatacttacc tatcatggga
     7081 ggaacaaccg ttcctctttt ttattactaa aattcaaaga attccaatgc ttttttcaag
     7141 agcaaatccg tatattctgg atcttcttgg gctacttcta tttcccgctg aactttttcc
     7201 aaatcatctg taatcactcc atctactcct aagtgaagag atttgctgat agcttctgaa
     7261 tcattgacag tccagacata aagtttctga tccgttgtcc atagtttgct tacaaaatat
     7321 tcatccaagg ttgagtactc catagtatat cctgtcgctc ttgttttagg aaagacagaa
     7381 ttgtagggca tgatgaaata aactggcagt tcggcatcat actgtcttac tttttcgaca
     7441 acatggtagt ctaaagactg gatttgatgt ccataaatct tgagctttgc agcataacgg
     7501 gctaaaaagc ggttcatcat gtctggacta tcttttttac tggttttaat ttcaattagt
     7561 aatttttgac caagttcgtt ggctcgactg agataatctt caaagcttga aattttagtc
     7621 tggtagccat tttcaaaaat atcaatccct ttaagctcct ccaagtttaa gtcttgagga
     7681 cttttattga tacctgctag atttttcaag ttagcatcat gcatcatgac aaactgccca
     7741 tcttttgttt cctgcacgtc cgtctccacc aagtctggtt tgagttgtgc tgtagtttcc
     7801 aaggactcta ctgtattttg aatcccattt gcattggaaa cccctcggtg agaaataagt
     7861 tgaggtagat gaaccatggg agcctccaga taaatataac cttctaaggc aaagaaaaga
     7921 ctggcacaag tcatgacacc ccatcgcacg atgtgatctt tttctctcct aggaagcata
     7981 tccagctcct ttcctgtcaa aaatgaaaca aatttaacca aaaaataagt cagagccata
     8041 taatagagat ttttaatcac gacaaaattc aaaataccaa gaatcagaga ctctctctga
     8101 gtgatatcat ctaccaaagt ttgagccaat aataaaggga tcaaaggaag ataaaataat
     8161 aaatgtgctt tgagcaagat gtaaaataaa ttccaagcat aaaaagtaac tctcttcttg
     8221 gttttctcca agctaaacat cactgcttct cgaacagtca gctgatcata tacaatcttc
     8281 ggaagggcaa acatcaatct gacagagaca tagagaaaga taagagatag aagtaggatg
     8341 ctcagccacc acatccaata tctatcttct aaataagctt ggataaactc tggaatgacg
     8401 attttattaa gataataaat cttcagcatt ttccgtataa aaggaaacag catagctata
     8461 tagaaaaaga taaacaaggc tttagcgcaa gttagctttt tcataaatcc aaaactttca
     8521 tggaaaacct tgcggatata ctcaattagc cttcgctttt cattatagag gagatgacga
     8581 gcaccaataa agaggagtcc tatttgaaaa taagcaacca gaaggttaat tacaatcaag
     8641 gctaaaaaag ctagactaat caatggagaa tgagtaagga tggctaagac attgttatag
     8701 gaaataaaaa gataacctgt ctgatctaat aagaagctag ccaaccatga attgaatggt
     8761 acccacaaat actccactat cataaaaatc aagaaaaata gaaagaggat tttatcaaga
     8821 ttgaggtaaa tctgtttaag acccaatttt ttaggttttt caggtttcat aggcactcct
     8881 agtcaaataa ttgagacaag tccaagccac caaaaggatt gtttgataag ctactttctg
     8941 tctctaacaa ttccctagct tgatccgact ctaagaagga ttcgtaaaca cgcgccgtca
     9001 tccgagcatc ctctaaacta ttatgagact gaccttgaaa tccaagaaat gaggcaacag
     9061 tttgcaattt gagattggca ataccatgta aatctgaact ccgacgttca aaagcttcat
     9121 catacaaatc caccttgtac tgttggctat agtctaaacc atgctctgct aaaataggta
     9181 aatcactttt agcagcattg tagcctatca tcagcaaaga acccacaaac tcttggaatt
     9241 cttctaagac tttctcaact ggaggagcat cttttaaggt ctcagctgta atcccggtca
     9301 aaccattgat aaagcttttt agagggacgc tggtatgaac ataggaatca taggcatcga
     9361 tttcccgacc atctctaaaa cgcactgccg atacttgaat caagtgtgtt tgtccttcgt
     9421 gctgattaaa ttctaagtca aaagcaatgt aatcttctaa tcgttccatt ctgtacctct
     9481 cctctactgt ctctgttcta atcaactata ctattcacaa acaaaagaag ccatcaggtt
     9541 agcatttaac ctaaacagct ccttgattat cctccaaata aacgagcaaa aaagcctttt
     9601 ttagtggatt ggacttcttc ttttgcttgg tccagctcta gcttaagatt ttcttgatcc
     9661 ttcatggctt gaagggtcaa ttgttgttgc tgatctaatt gtttgtcttt ctcagcaatc
     9721 tgacggtctt tgatacgcat ctgctcgtct ttttctgata actgacgatc cttggctttt
     9781 aattgttcat aaagacgaag aatttctgca ttcttctcat ccactagaat ctccatcagt
     9841 tcacgttgtt tgacatcttc actgacaggt tcatcttcaa aaatcgtttt tttatagatt
     9901 tcttctagct taatcaagcc acttctggta acaactgtta cccctttgtc atttttatct
     9961 gtgtcttctt ctggtaattc tttgacacgg ttattgattg cttggcgaga taatcctaag
    10021 atctctgcaa tctcactgac ggtcatttca atactcataa tatcctctga aacgttttct
    10081 agcttttctt tacttaaatc ttatcataag ctagaaaaac tgtcaaattt ccgcttaatc
    10141 taaagccttc aaaaaggcca acaagacttg ggcagagcga cgtccagctt cgataataaa
    10201 ctcatcaaaa aagatgtttg cttcatggtt ggcattgtca ctcatagctc tgatgactaa
    10261 gactgggaga ttgagggcat gcgctgcttg agcaatagct gccccctcca tctccacggc
    10321 taaaacttct gggaaatggg acttaatcgc ttctatcttg tcatttcctg caacaaaact
    10381 atctcctgta gcaatcaaac caagatgcca gttttggtcc aattgagata aactctcttg
    10441 gatttgagca acaaaggttt tgtctgattc gaaataaagc ggttgttgcg ccatttgtcc
    10501 ataagcatag ccaaaagctg tgacatccac gtcatgatag gctaatttgt cagcaatcac
    10561 gacatcccca acagcgatac cttctgctac tgccccagct gaacccgtat taataagggc
    10621 atccacctgg aaatgatcag ccaaaatcgc cacactcata gcagacatga ccttaccaat
    10681 tccactttct acaagaacga cttcatgaga agcaatggtt cctgtatgat aggtattccc
    10741 caaaacaact tgctcctggg cattgtctaa atgctggacc agatgagcca gttcttctgg
    10801 catagcagca ataattccta ttttcatttc aattcctttt ctattacaaa agtttcattg
    10861 ctaaaacaag caaaatcaag agaaagatga ccgcgaataa gattttattc aacttagaat
    10921 tgaagacatt tctcttggta ttttcaatgc gacggctttt atgaatagat ggttcgacct
    10981 gaatcttcaa ggtttcctgg ctaaaaccat gatccttagg attggcataa ccaaaacggg
    11041 aagaagaggt tggtaaaatc ttagtttcct cattatcatc cagcaaagga ggacctgaaa
    11101 ttttttcgcc tctattagct ctttcaatca tttcatccgt taataaagat ttacccatac
    11161 tgacctcctc tattttttct gcaactccca atactgaaca gccataattg tcttggcatc
    11221 acagatatga cctgattgga ttaattcttt cgcttcttct aagctcactt caaggacttc
    11281 caaggtttca tcctcatcct gcggacgcgg attttccact tttgtcaaat cgcttgctaa
    11341 atatagtttt aacttctcat tacaaaagcc aatagctgaa taaaaatcgt acaagagttc
    11401 taatttccct gtataggctg tttcttcctc taattcacga agggcagctg ccacaggggc
    11461 tgtgttttct cctacctcca attttccggc tggaatttcg taagagacag cctcgatagc
    11521 tttgcggtac tgcttgacca agataagttt ttgttcatcc gttactgcta aaacacagac
    11581 agccccattg tggaaaatca aatcccgttg ggcagttccc ttgccttctg gtaattcaac
    11641 ctgatcttgg accagtttaa atattggtcc ttgatagatt tcttttcggc taagcgtttt
    11701 ttcttcaaac tccatgatag gctcctactg gttcctagga tgatgaggaa gacgtgttgc
    11761 atattcgtct ttattgatct gacgaccgcg accaatagca atagcatctg ctggcacgtc
    11821 tttagtaata gttgaaccag caccaacgag ggaattgtca ccaagttcta ctggtgcaat
    11881 aatggttgaa tttgaaccaa caaagacatt gtctccaatg actgtcttgt atttgttttt
    11941 gccgtcatag ttgactgtaa tagttccagc accgaaatta acgttgcttc ccacttcaca
    12001 gtttccgata taagtcaaat gaccagcctt ggtattctca ccgattgaag atcctttcac
    12061 ctcaacaaag ttaccaatat gaacttgggc acccagactt gaatttggac gaatgtgagc
    12121 ataaggaccg actgtcacac cgtctgcaac actactttcc tcaatcatag aattggtaat
    12181 gaccgctcct gctccgatag tgctgtccac tacataagta ccgtttgtca aaacagtctc
    12241 agcaccaatt ttcgtttgcc ctttcaaggt aacattggct tcgatttgaa cttccggagc
    12301 aatctcaaca tcaatatcga tataagttgc ttctggattg acaaagctaa caccattgac
    12361 catgtgttta tgattgatgc gacaacgcat aactgactca gctgtcgcaa gcgccacacg
    12421 gtcatttacc ccaagacttt catcaaaatc tttcaaagta taagcgccaa ctttttcacc
    12481 agtttcacgg aaaataccaa tgacgtctgt aatatagtat tcgccttgag cgttattggt
    12541 attgatattt ttcaaagcct caaacaaacg ctcgttgtca aagacgtatg ttccagtgtt
    12601 gatttccttg atttgctttt caaaatctgt agcatccttc tgctcaacaa tacgaagaac
    12661 ctcagcattg tcattacgaa caattcgtcc atagccaaaa ggattatccg tttcagcagt
    12721 caagatagtg gccacatttt tatgattgat atggaaatca atcaagtttt tcaagctttc
    12781 accagtgatt aaaggagtat ctcctgcaat gaccaaggtg tgtcctgaca aaccttctaa
    12841 gataggctct gtcatcataa ctgcatgacc agttcccaac tgttcagatt gagtcacaaa
    12901 ttctgtctgt ccagccaaga cctcctcaac caattctgcc ttgtgtccta caactgttac
    12961 tgtcttttca ggttggatag ctcccacact acggaaaaca tgttccaaca tagaaatacc
    13021 cgcaaccttg tgcaaaactt ttggcaaatc agatttcatg cgagtccctt tacccgctgc
    13081 taaaataatg gcaaaatttg acataatctt ctctttcctg tagaaattcc cttttattat
    13141 accatatttc aaatcattcc gcactcttga atgaaaaaat gctctaaagt ctcttcctta
    13201 acccattttt ttgattttta gggtagaatt ataagatatg agaaaacaaa ttcatccact
    13261 tattttattt agttttttgg ggattatgat gttcatttta atcatcaatc gcccacttaa
    13321 tgacaaccaa tcgtttaaaa caaaatccaa tatagcacag attgaagcac aggctttgaa
    13381 acacttagac aaaccgatta ttgacctctc tggctggcag catcctgagg aaatcaacta
    13441 cgatgccctc tcacaaaata tttcaggtgc tattgttcgt gttcacagtg gtgctcaaac
    13501 gacaaaagaa aatgatgctt catttatcaa tggaatagac aaggcctata agagtcatat
    13561 cactgaactt caaaagcgga atgtcccagt tgctgtctac gcttatgtag ctggaaaaag
    13621 tgtccaagaa atggaaaagg ctgccgaagt tttctacaat gctgcctctc cttacagccc
    13681 tagttactat tggcttgacg tggaagacaa aaccatgtct aatatgaacg aaggtgtcga
    13741 aaactttcga gcaaaactag catcactagg tgctaaaaac atcggcatct acgttggtgt
    13801 ctacttcatg gaagaacaca gtattgatac aggcaagttt acctctattt ggattccgtc
    13861 ctacggctca gactcaggat ttttggagag cagtcctaaa actgatttag attatgatat
    13921 tcaccaatac acatctaaag gaaaaattgc cggctttgac cacgatttag atatcaacgt
    13981 tatctctccc ttaaaaaata aagaagaaac ctttcgaaaa ctttttttaa aaccttaaaa
    14041 gcatttgttt atcatttgct ttttcttttt gtgtctgatt gtgatacaat atagtaagga
    14101 ttttttgaaa tagaaatagt tggaggaaat atatgctctc atggttagca cgcgttatta
    14161 aaggaattgt gattgctctt ggatttatcc taccgggaat ttccggaggg gttctagcag
    14221 caatcttagg aatctatgaa cgaatgattg gctttctggc tcatcccttt aaagacctta
    14281 aagaaaatgt tttgtacttt attccagttg ccatcggtat gcttctggga atcggcttat
    14341 tttcctaccc gattgaatac ctgcttgaaa attatcaggt ctttgtatta tggagctttg
    14401 cgggagctat tatcggtaca gttcctagcc tcctcaaaga atcaactcga gaatctgacc
    14461 gagacaagat tgatttagct tggttatgga caacctttat catttctgga ttaggactct
    14521 attccttaaa ttttgtcgtt ggaaccttaa gcgccagctt tcttaacttc gtcctagcag
    14581 gcgcactatt ggcccttggc gtcttggttc ctggcctcag cccatcgaat ttacttttga
    14641 ttttgggact ctatgctcct atgttgactg gttttaaaac ttttgatctc ttgggaacct
    14701 tctttccgat tggaattggt gcaggtgcaa ctctcatcgt tttttcaaaa ttgatggatt
    14761 atgccttaaa caactaccac tcacgcgtct atcatttcat catcggtatc gtcctatcaa
    14821 gtaccctttt gatcttaatt ccaaatacag gaaacgctga aagtatccaa tacacaggac
    14881 tttcacttgt cggttatgtc atcatcgcct tcttctttgc gctgggaatc tggcttggta
    14941 tttggatgag tcaattggag gataaatata aataatggca aaaaaagtta aaatcaaaaa
    15001 aacattggtg gaacaaatcc tatctaaagc agctatccct catcagggga ttcaaatcaa
    15061 tgccctagaa ggagagcttc ctcaaggtta tgaacgagat cagattttca aaaccttggc
    15121 gcttttggga gacaagaccg gaccgattat cggaattgtc cctatcactc agcacttgtc
    15181 tgaaaagaaa ctagctaaaa tttctggcaa taaaaaagtg agcatgattc cacaaaagga
    15241 cttagaaaaa acaactggtt acattcatgg agccaataat cctgtcggaa ttcgtcagaa
    15301 acacaattat cccattttta tcgataaaat tgctctagat ttggatcgaa tgattgtctc
    15361 tgcaggcgaa gtcggacaca gcattatcgt cgcgccacaa gacttggcta gctttgtaaa
    15421 ggcagacttt gtagatattt tggaggacat caagtaatga aactctactt tgtccgccac
    15481 ggtcgtaccc tctggaacca agaaggtcgt tttcaaggtg ctagcggtga ttctcctctt
    15541 cttcctgaat ccattgaaac cctaaaacga cttggccagt atctcaagga aattcctttt
    15601 gatcagattt attcaagtga tttacctcga gcggtcaaat ctgctgagat tatccaaagt
    15661 caactccata ccccctgttc tttagaaatc gttcctaatc tccgtgaatg gcaacttggg
    15721 aagttagaag gtttgaaaat tgcaaccttg gaagctattt acccgcaaca aatccaggct
    15781 tttcgttcaa atcttgctca atttgacact cgaatgttcg gagccgaatc cctctatagt
    15841 acaactcagc ggaccatcca atttatcaaa tcattaaaag atagtccagc tgatcgtatt
    15901 ctaattgtcg gacacggcgc caatcttact gccagtcttc gtactctcct aggctataaa
    15961 gaaccacttc ttcgtaaaga tggcggtcta gcaaatgcca gcctgaccat tatagaaacc
    16021 catgattttg aaacattcac tctcaatact tggaatgata cttcttatca atcataatta
    16081 tagcctagcc ttctgaacta gaaccatagg agatatagtc agttgaaaca aaaataagac
    16141 aaaagaacct tgtaaaaagg tattgcaact tgccaatacc tttttgatat gaacacgtgt
    16201 cttctcaaca ggattgtaga gcaaaatgaa ataagaactg aataatatga tttgagaatt
    16261 taaatcaatt tataagaatg ttttagaagc agttatgtac tattttagat tcacttttct
    16321 atactaagat gagtagggag gaaaaggtaa aagtttatgc ccaaattctt cacataagaa
    16381 ctctagctta cccattctat ggaatcttgc attatccatt aaaacttcca gactcatacc
    16441 cttctaaaat ctattcaaac cacgtcagct tcacattata tatgttggtg acctcacaag
    16501 ttttatctac aacctcaaag ctgttctttg agcagcctac agctagcttc ctagtttaat
    16561 ctttgctttt cactgagtat caagttaaaa aaatgaggct ggtcaaaaag tctttaaaat
    16621 aaaaaacgca tattatcagg tgttaaatga actgcacccc aaaagttaga cagaaaaaat
    16681 ctaacttttg gggtgttttt attatgaaat taacttatga tgataaagtt cagatctatg
    16741 aacttagaaa acaaggatat agcttagaga agctttcaaa taaatttgag ataaacaatt
    16801 ctaatattag gtacatgatt aaattgattg atcgttaatg ttggaacagg cattcaaaga
    16861 gaagcactac gagaatacga ttctccatag tgaccaaggc tggcaatatc aacacgattc
    16921 ttatcatcgg ttcctagaga gtaagggaat tcaagcatct atgtcacgca agggaaacag
    16981 ccaagacaac ggtatgatgg aatctttctt tggcatttta aaatccgaaa tgttttatgg
    17041 ctatgagaaa acatttaaat cacttaatca attggaacaa gccattatag acta
//
LOCUS       DBMVGT010000036        16582 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.036, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000036 DBMVGT010000000
VERSION     DBMVGT010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 16582)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16582)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16582
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.036"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..380
                     /gene="rpsI"
                     /locus_tag="AC0DU4_001320"
     CDS             <1..380
                     /gene="rpsI"
                     /locus_tag="AC0DU4_001320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002942223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HIN4237276.1"
                     /translation="YAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVIN
                     QPFAVTSTVGSYDVFVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAGLLTRD
                     SRKVERKKPGLKKARKASQFSKR"
     gene            729..938
                     /locus_tag="AC0DU4_001321"
                     /pseudo
     CDS             729..938
                     /locus_tag="AC0DU4_001321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            1094..1432
                     /locus_tag="AC0DU4_001322"
     CDS             1094..1432
                     /locus_tag="AC0DU4_001322"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000176371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_process: GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="antibiotic biosynthesis monooxygenase family
                     protein"
                     /protein_id="HIN4237277.1"
                     /translation="MTLTIHVYYKGDGDSAIKFAREMLDSGLVKEIRNQKGNLKYEYF
                     LPIEKEGTILLIDQWINQETLDKHYQSKTMQKILDLRKKYHLQMQVERYIEDDSGMPE
                     SDKSFIDTGN"
     gene            1622..3058
                     /locus_tag="AC0DU4_001323"
     CDS             1622..3058
                     /locus_tag="AC0DU4_001323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HIN4237278.1"
                     /translation="MTTFKDGFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVA
                     REITLGVLEGKYYPNHEAIDFYHRYKEDIALFAEMGFKCFRTSIAWTRIFPKGDELEP
                     NEEGLQFYDNLFDECLKNGIEPVITLSHFEMPYHLVTEYGGWKNRKLIDFFARFAEVV
                     FKRYKDKVKYWMTFNEINNQANYQEDFAPFTNSGIVYEEGDNREAIMYQAAHYELVAS
                     ARAVKIGHEINPDFQIGCMIAMCPIYPVTCNPKDILMAMKAMQKRYYFADVHVLGKYP
                     EHIFKYWERKGISVDFTDQDKEDLLGGTVDYIGFSYYMSFAIDSHRENNPYFDYLETE
                     DLVKNNYVKASEWEWQIDPEGLRYALNWFTDHYHLPLFIVENGFGAIDQVAADGMVHD
                     DYRIEYLGAHIREMKKAVVEDGVDLMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDN
                     GKGSYNRSPKKSFGWYKEVISSNGESVE"
     gene            3110..3349
                     /locus_tag="AC0DU4_001324"
     CDS             3110..3349
                     /locus_tag="AC0DU4_001324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000580385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051119 - sugar transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SemiSWEET transporter"
                     /protein_id="HIN4237279.1"
                     /translation="MIGSIAAILTTFAFLPQVFRIVKTKDTGSIALGMYVMQVIGIAL
                     WLAHGIRIGDLPLILANSVSFLLSGIILFYKLKYK"
     gene            3479..3793
                     /locus_tag="AC0DU4_001325"
     CDS             3479..3793
                     /locus_tag="AC0DU4_001325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003037418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIB"
                     /protein_id="HIN4237280.1"
                     /translation="MAKALIICAAGMSSSLMAQKTTEFLKGKGKDIVVDAISATEGGK
                     AIAAAAFDLYLVSPQTKMYFKQFEEAGSKAGKPVVQIPPQAYIPIPMGIEKMANLILE
                     NI"
     gene            3911..5891
                     /locus_tag="AC0DU4_001326"
                     /pseudo
     CDS             3911..5891
                     /locus_tag="AC0DU4_001326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001101767.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
     gene            5901..6215
                     /locus_tag="AC0DU4_001327"
     CDS             5901..6215
                     /locus_tag="AC0DU4_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001070943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIA"
                     /protein_id="HIN4237281.1"
                     /translation="MNQEELQVAAFEIILHSGNARSEIHEAFAKMREGSFDDAESKLN
                     QSNEIILEAHHAQTKLLQEYASGVEIKIEIIMVHAQDHLMTTMTLLEVAKEMLALYKK
                     VN"
     gene            6246..6752
                     /locus_tag="AC0DU4_001328"
     CDS             6246..6752
                     /locus_tag="AC0DU4_001328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237282.1"
                     /translation="MDKKERQKIEQQRREMALTNTFFNRYLLLRYSIALFFFGNIYWL
                     LSQFISPSPIIIFPIMLIVFSILATVEQFKLYGNRKEKLGITLMFVRIQMLISIGLLV
                     LTWTSWFKNLFPIFENNQVARLFVFVVLLLGLALSLLDIRRIKKIYKRTDKAYQQFVQ
                     LEKNSLSL"
     gene            6832..8178
                     /gene="celB"
                     /locus_tag="AC0DU4_001329"
     CDS             6832..8178
                     /gene="celB"
                     /locus_tag="AC0DU4_001329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIC"
                     /protein_id="HIN4237283.1"
                     /translation="MDQQNGLFGFLENHVMGPMGKLAQFKVVRAITAAGMAAVPFTIV
                     GSMFLVFSILPQAFSFWPIVADIFSASFDKFTSLYMVANYATMGSLSLYFVLSLAYEL
                     TKIYAEEEELNMNPLNGALLALMAFVMTVPQIIFDGGMMKTVTSLKEGAVIADGWAMG
                     NGVARFGTTGIFTAIIMAIVTVLIYRMCVKHNWVIKMPEAVPEGVSRGFTALVPGFVV
                     AFVVIFINGLLVAMGTDIFKVIAIPFGFVSNLTNSWIGLMIIYLLTQLLWIVGIHGAN
                     IVFAFVSPIALANMAENAAGGHFAVAGEFSNMFVIAGGSGATLGLCLYIAFASKSEQL
                     KAIGRASVVPALFNINEPLIFGLPIIYNPALAIPFILAPMVTATIYYVANSLNFIKPI
                     IAQVPWPTPVGIGAFLGTADLRAVLVALVCAFAAFLVYLPFIRVYDQKLVKEEQGI"
     gene            8560..8736
                     /locus_tag="AC0DU4_001330"
     CDS             8560..8736
                     /locus_tag="AC0DU4_001330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237284.1"
                     /translation="MSLDIDKEKMTIMGIAFENRSVFKSVWYALSTNMIEGWRPTVSD
                     VEKLRDEALALGMT"
     gene            9137..11350
                     /locus_tag="AC0DU4_001331"
     CDS             9137..11350
                     /locus_tag="AC0DU4_001331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="HIN4237285.1"
                     /translation="MKIFKGEFYRISVLTDKLVRLEYSRTGNFEDRTTQLIYNRDFGQ
                     VSLDYIETSNVLDIMTDYFHLHFNKGEFNAENLFIELKGNFAVYGSRWYFGESIETLK
                     GTARTLDKADGAISLEDGIISRNGIALLDDSQGFIWDEQSGYIERENQIDLYFFAYGH
                     DYRGAIRDFYHLTGSTPLLPRYALGNWWSRYWPYTSDEYLDLIDRFETEKIPLSIGVL
                     DMDWHITDIPARFGSGWTGYSWNKNLIPNPEQLLQQLHDRKLKLSLNVHPADGIRAYE
                     EAYPQVAKRLGLNVELEEPAIFDFFNPSFREAYFKDVHYELEKQGVDFWWIDWQQGTQ
                     GILDPLWLLNHYHYQDSCKNAEGGLILSRYAGPGSHRYPVGFSGDTIISWNSLRFQPY
                     FTATASNIGYSWWSHDIGGHMLGDYDEELQTRWLQFGVFSPITRLHSSRSPFNSKEPW
                     FFSETTSKIMKKYLRLRHQMIPYLYTMNVKTHEEGAPLISPIYYFYPENDESYNVPNQ
                     YFFGTELMVAPIVEKMDLAFQSAKVDVWFPEGEWYDFFSEKKYTGGVKLSVYRDISTI
                     PVFAKSGAIIPLVGSEIDMGVDLPEVVDWYVFPGKQHSFEMLEDQNGQRYKTRLSIDW
                     EMGMVELTLQGDSSIVPSNRRHRIHFKGTNVSIIELPNKNDTARFECKDNKTISLNDE
                     VFRLLKTASLPYELKDRLLNQFINAKNSHDLMNILHHQDKELRGRLLEMIFTSQN"
     gene            complement(11572..12048)
                     /locus_tag="AC0DU4_001332"
     CDS             complement(11572..12048)
                     /locus_tag="AC0DU4_001332"
                     /EC_number="1.11.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004602 - glutathione peroxidase activity
                     [Evidence IEA];
                     GO_function: GO:0043295 - glutathione binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione peroxidase"
                     /protein_id="HIN4237286.1"
                     /translation="MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTATGCGLTPQYQG
                     LQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINAFCSLHFQTTFPRFAKIKVNGKE
                     ADPLYVWLKDQKSGPLGKRVEWNFAKFLIGRDGQVFERFSSKTDPKQIEEAIQTLL"
     gene            12271..15474
                     /locus_tag="AC0DU4_001333"
     CDS             12271..15474
                     /locus_tag="AC0DU4_001333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored hyaluronate lyase"
                     /protein_id="HIN4237287.1"
                     /translation="MQTKTKKLIVSLSSLVLSGFLLNHYMTVGAEETTTNTIQQSQKE
                     VQYQQRDTKNLVENGDFGQTEDGSSPWTGSKAQGWSAWVDQKNSSADASTRVIEAKDG
                     AITISSHEKLRAALHRMVPIEVKKKYKLRFKIKTDNKIGIAKVRIIEESGKDKRLWNS
                     ATTSGTKDWQTIEADYSPTLDVDKIKLELFYETGTGTVSFKDIELVEVAAQLSEDSQT
                     DKQLEEKIDLPIGKKHVFSLADYTYKVENPDVASVKNGILEPLKEGTTNVIVSKDGKE
                     VKKIPLKILASVKDTYTDRLDDWNGIIAGNQYYDSKNEQMAKLNQELEGKVADSLSSI
                     SSQADRTYLWEKFSNYKTSANLTATYRKLEEMAKQVTNPSSRYYQDETVVRTVRDSME
                     WMHKHVYNSEKSIVGNWWDYEIGTPRAINNTLSLMKEYFSDEEIKKYTDVIEKFVPDP
                     EHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGEGF
                     YQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKSPIDKDKMQTMYHWIDKSFAP
                     LLVNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQRLQSLVKTIVQ
                     SDSYYDVFKNLKTYKDISLMQSLLSDAGVASVPRTSYLSAFNKMDKTAMYNAEKGFGF
                     GLSLFSSRTLNYEHMNKENKRGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTE
                     TDAKRADSDTGKVLPSAFVGTSKLDDANATATMDFTNWNQTLTAHKSWFMLKDKIAFL
                     GSNIQNTSTDTAATTIDQRKLESSNPYKVYVNDKEASLTEQEKDYPETQSVFLESSDS
                     KKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKEVENEFLTISQAHKQNGDSYGYM
                     LIPNVDRATFNQMIKELESSLIENNETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVL
                     KRGVYTIRKEGDEYKIAYYNPETQESAPDQEVFKKLEQAAQPQVQNSKEKEKSEEEKN
                     HSDQKNLPQTGEGQSILASLGFLLLGAFYLFRRGKNN"
     gene            15854..16230
                     /gene="tnpA"
                     /locus_tag="AC0DU4_001334"
                     /pseudo
     CDS             15854..16230
                     /gene="tnpA"
                     /locus_tag="AC0DU4_001334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002458050.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
BASE COUNT         5501 a         2473 c         3398 g         5210 t
ORIGIN      
        1 aatatgcagg tactggacgt cgtaaaaacg ctgttgcacg cgttcgcctt gttccaggaa
       61 ctggtaaaat cactgttaac aaaaaagatg ttgaagagta catcccacac gctgaccttc
      121 gtcttgtcat caaccaacca ttcgcagtta cttcaactgt aggttcatac gacgttttcg
      181 ttaacgttgt aggtggtgga tacgctggtc aatcaggagc tatccgtcac ggtatcgctc
      241 gtgcccttct tcaagtagac ccagacttcc gcgattcatt gaaacgcgca ggacttctta
      301 cacgtgactc acgtaaagtt gaacgtaaga aaccaggtct taagaaagct cgtaaagcat
      361 cacaatttag taaacgttaa ttcgaaagaa ttactatact tatacagagc acctttcggg
      421 gtgttctttt tttatacttt cttactaaat tggtgcaatt gacacagttg ttgcgacttt
      481 agtcgcttac aaatgtggct gcaacctgac aaggtcagtt gcctcaaaac gttaatcaat
      541 acgattatat caatgtttca aagcactcaa aagtttacct tatgggtgct tttttcgtgc
      601 ttttttgaaa agtttacctt atttttatag taatatgaaa taagaatagg acaaatcgag
      661 gatagtcaaa tcgaattcta acaatgtttt agaagtagag gtgtactatt ctagtttcaa
      721 tctactatat tatggataat gcaagattcc atagaatggg gaagctagaa ctcttgtgtg
      781 aagagtttgg gtataaactt ttacctcttc ctccctactc acctgagtac aatcctattg
      841 agaaaacatg ggctcatatc aaaaagcacc tcaaaaaggt attaccaagt tgcaatacct
      901 tttatgaggc tcttttgtcc tgctcttgtt tcaattgact ataaatcgct ataagaaaaa
      961 atcattttat tggtataaag aagtgattga aagtaatggc gaaacgttag ataattagtt
     1021 cataaaaaac aagtttagat cctcatctaa acttgttttt ttaaaattga aggatgattt
     1081 tggaggatat aagatgacat tgactattca tgtatattat aaaggtgatg gagatagtgc
     1141 aataaagttt gcaagagaaa tgcttgatag tggccttgtt aaagaaatta gaaatcaaaa
     1201 aggtaacttg aaatacgaat attttttacc aattgaaaaa gagggaacta ttctccttat
     1261 tgatcagtgg ataaatcaag aaactttaga taaacattat caatcaaaga caatgcagaa
     1321 aatcttagat ttaagaaaaa aatatcactt gcagatgcaa gttgaacgtt atatagaaga
     1381 tgattctggg atgccagaaa gcgataagtc gtttatagac acagggaatt agaattattg
     1441 tgagagtttt tgtagtttga aagtattgaa aatcgtaaag atatcattac gagaatacaa
     1501 gaagatattg ttctatttcc attaaaaatt acttctttcc ttaacaataa ggaaaaagaa
     1561 tgcgttttca tcttttggtt taaggtttat aataagagta tcaaagtcag gaggaaaaaa
     1621 gatgactact tttaaagatg gatttttatg gggtggtgct gttgctgctc atcaacttga
     1681 aggtggatgg caagaaggtg gcaagggaat tagtgttgct gatgttatga ctgctggtcg
     1741 tcatggagta gctcgtgaaa ttactttggg agttttagag ggtaaatatt atccaaatca
     1801 tgaggcgata gatttttatc atcgttataa agaagacata gcactttttg ctgaaatggg
     1861 attcaagtgc ttccgtacct ctattgcatg gacacgtatc tttccaaaag gtgatgagtt
     1921 agagccgaat gaagaaggat tacagtttta tgataatctt tttgatgaat gcttaaagaa
     1981 tggtattgaa cctgtcatca ctctatctca ttttgaaatg ccttatcact tagtgaccga
     2041 atatggtggt tggaaaaata ggaaattgat tgatttcttt gctcgttttg cagaagtcgt
     2101 atttaaacgt tacaaagata aggttaaata ttggatgact ttcaatgaaa tcaataatca
     2161 agcgaattat caggaagatt ttgcaccatt tactaactca ggtattgtat atgaggaagg
     2221 tgataataga gaagcaatta tgtatcaagc agcacattac gaattagttg cttctgcacg
     2281 agctgtaaaa attggtcatg agattaatcc agattttcaa ataggttgta tgattgcgat
     2341 gtgtccaatt tatccagtta cttgcaatcc taaggatatc ttaatggcaa tgaaagctat
     2401 gcagaagcgt tattattttg ctgatgtgca tgttttaggt aaatatcctg agcatatttt
     2461 caagtattgg gaacgaaaag gtatttcagt tgattttact gaccaggata aagaagattt
     2521 acttggtggg actgtagatt acattggttt cagttactat atgtcctttg ctatagactc
     2581 tcatcgtgaa aataatcctt attttgatta tcttgaaaca gaagatttag tgaaaaataa
     2641 ttatgttaag gcttctgaat gggagtggca aattgatcca gaaggtttac gttatgcgtt
     2701 aaattggttt acagaccact atcacttacc actctttatt gttgaaaatg gttttggagc
     2761 tatagatcaa gttgcagcag atggtatggt acatgatgat tatagaattg aatatctagg
     2821 tgcccatatt cgtgaaatga aaaaggctgt agttgaagat ggtgttgatt taatgggtta
     2881 tactccatgg ggatgtattg atttggtttc agctggtacc ggtgaaatgc ggaaacgtta
     2941 tggttttatt tatgtagata aagatgacaa tgggaaggga agttataatc gttccccgaa
     3001 aaaatctttt ggctggtata aggaagttat ttcatctaac ggtgaatcag tagaatagta
     3061 taaacaaact gagattattc tcagtttgtt tagcatattg ggatgacata tgattggaag
     3121 tattgcagca attttaacaa catttgcatt tttaccacaa gtttttcgta tagttaagac
     3181 aaaggacaca ggatctattg ctctaggtat gtatgttatg caagttattg gtattgcatt
     3241 gtggcttgct catggtattc gtataggaga cttgcctttg attttagcaa atagtgtttc
     3301 atttctactc tcaggaataa ttttatttta taaattgaag tataaataat ttttttccat
     3361 atcatttagg aaaatgaggg aattgtcatt ggaaacgctt tattttataa taaaaataga
     3421 taacaaataa gccaacttag cacagctttg attggattta agaaaaggag aaaatattat
     3481 ggcaaaagct ttaattattt gtgcagcagg aatgtcttca tcacttatgg cacagaaaac
     3541 aacagagttt ctaaaaggaa aagggaaaga tattgtagtt gatgctatta gtgctactga
     3601 aggagggaaa gctatcgcag cagcagcttt tgatttgtat cttgtcagcc ctcaaacaaa
     3661 aatgtacttt aagcaatttg aagaggctgg ttctaaagca ggaaaaccag ttgtacaaat
     3721 acctcctcaa gcctatattc ctattccaat gggaattgaa aaaatggcta atttgattct
     3781 tgagaatatt tgatgaacac atgaaatgtc aataaatatt taggttaaga taaattgttt
     3841 tgagtttgat ataaactgat ttaagtgtat aatatgcttc aatatatgaa aacatacgtt
     3901 ttaggaggga atgaatgtgt taaacattaa agagaaagat atccttcaat ttttaataaa
     3961 aaataaggaa cgttttgtta caagcaaaga actggcagaa tatttatcct gttcagatag
     4021 aactgtccgt aatgtactga aattaattga gaagacaatg attattcaag gagtccggtt
     4081 gatttcaaaa caaggtcaag ggtatcaaat attttttgag aatcaaggcg cttaccagga
     4141 gtttagacaa acttatgaac tggaagaaga ctatacgaaa actgcggttt caaaaggtga
     4201 tgatcgttta gtatttatct taaataaatt attatttgag caagttccag ttctttttga
     4261 tgatttagct gatgaacttt acgttagccg ttcaacatta tctcatgatt tcagaaagat
     4321 acgagtgatg ttatcagagt ataatttgtc cattgagagt agggcgaata aaggagttta
     4381 tgtctcaggc gaggaacgtg ataaacgacg ttttatcata aattatttcc tagagaatca
     4441 attttttaaa acaatacatt gctatgtaaa atttaacttt tttgatcaaa ctgttccatt
     4501 agaagaattt gctagaattg ttttggatga atgccaagag gccaacctaa aactatctga
     4561 ttttgtacta cagaatttag tagttcacat agcattgtct gtgattcgtt taaaatccgg
     4621 atttgaaata aaaaatatag actgtcagat gactgatgat gcaatagaga gaaaggttgc
     4681 ccaaagaatt ctttctaaag taagagaagt aacaaatcag gaatttccag ttcaggaaat
     4741 agactacatt actttgcatt tgttagctaa gagtcaacaa tgtcaaaaaa atcagaagaa
     4801 tatttctgaa gaagttttaa aaaaaatctt tatttaaaac atttcagaat ttaggattag
     4861 atgatatgta taacttttct tcagatttcc aactaattga aggattgata actcatctaa
     4921 tgacactaca agtacgttta gaaagccgga ttaccttaaa taaccctttg gtagatgaaa
     4981 ttaaacagaa ttatagtgat atattcttta tgactagaga aattcttgca aatatggaca
     5041 agttcttgga gtggacaata tcagatgatg aagtagcata tgtaagtctt cactttttag
     5101 ctgctatgga acgtagcaaa gagagtacta agtttaatat tcttgctatt tgtgcaacag
     5161 gatttggtgc agcccaaatg ttaagaaatc gtttggaaac ggagtttggg aagcgagtag
     5221 aagttgttga tgtaataggc tactatgaat tgaatcaaga aaaacttaaa ggaatagatt
     5281 ttatagtgtc agctgttgat ttatcaaatc tatattttca aatcccagtt tttaaagtta
     5341 gtgtgtttct taaaagtgat gagatggaaa tgattagaaa agctatggat cagatgcaag
     5401 tttctagtta tgtacaatca tcaaagatta acaaatttga aaacaacggc tttagacagt
     5461 attttagtaa agaaaatttt ttaatatgta ctgaatcaga caaggtaaat ttacttgaaa
     5521 agatggttga gggtttatct gttggtgaat caaatgagtt tgaacaatct ttactttatg
     5581 gaattaaaca gcgcgaagaa ttaagttcag ttgttttttc tgaaaaaatt gcagttccgc
     5641 atcctattca gccctttggt acagagggaa aggtttcggt tgcaatttgt aaagattcgc
     5701 tactctggga taatcaaagt tcacatgtcc agctagtatt tcttctatct ccatcaatat
     5761 atgggaacga aggtttggca actgtgacta aaaagatagt ctctctgaca gagaatgatg
     5821 aattgcaaaa tcagctaata tcttgcaata actttgaaga ttttattaac atatttgaga
     5881 agataaaata ggaggttcat atgaatcaag aggaactgca ggttgcagca tttgaaatta
     5941 tcctgcattc gggaaatgca aggtcagaaa tacatgaagc atttgcaaaa atgagagaag
     6001 gtagttttga tgatgcagaa agtaaattaa atcaatcaaa tgagataatt cttgaagcgc
     6061 atcatgcaca aaccaaactc ttgcaagaat acgcaagtgg agtggaaatt aaaattgaaa
     6121 ttatcatggt acatgctcaa gatcatttaa tgaccactat gacattatta gaagtagcaa
     6181 aggaaatgtt agctctttat aagaaagtta actaaatatg tgttgttata taaggaggaa
     6241 atgatatgga taaaaaagaa cgacaaaaga ttgaacaaca acgtcgagag atggctctaa
     6301 ctaatacttt ttttaatcga tatcttcttc tacgttattc aatagcactc ttcttttttg
     6361 ggaatattta ttggcttttg agtcagttta ttagtccctc gcctattatt attttcccca
     6421 ttatgctcat agtattttct attttagcaa ctgttgaaca atttaaactc tatggaaata
     6481 ggaaagaaaa gttgggaata acactaatgt ttgttagaat acaaatgctt atttcaatag
     6541 gattacttgt tttaacttgg acaagttggt ttaagaatct ttttccgatt tttgaaaata
     6601 accaagtagc acgtttattt gtttttgtag ttcttctatt aggtttagct ctgagtttgt
     6661 tagacattag aagaattaaa aaaatttata aacgaacaga taaggcttat caacaatttg
     6721 tccaattgga aaagaactca cttagtttat aatcctgatc tagtataatt tgtatttgaa
     6781 accagtcttt agaaagtaaa aattattatg ttttattaag gaggtctatt tatggatcaa
     6841 caaaacgggt tgtttggttt tcttgaaaac catgttatgg gaccaatggg caaacttgct
     6901 cagtttaaag tagtgcgtgc tatcacggct gcaggtatgg ctgctgtacc atttactatt
     6961 gtaggatcaa tgtttttggt attcagtatt ttgccacaag ctttctcatt ttggccaatt
     7021 gtggcagata ttttctctgc ttcatttgat aaattcacat cactttacat ggttgcaaac
     7081 tatgcgacta tgggttctct atctctttat ttcgttctat cacttgcata tgaattgaca
     7141 aaaatttatg cagaggaaga agaactcaat atgaatcctc ttaatggtgc cttgcttgcc
     7201 ttgatggctt ttgtcatgac agtaccgcaa atcatttttg atggtggaat gatgaagact
     7261 gtgacaagtc taaaagaagg tgcagtaatt gcagatggat gggcaatggg aaatggagtc
     7321 gcacgttttg ggacaacagg gatttttacc gcaatcatta tggcaattgt gactgttctt
     7381 atttatcgta tgtgtgttaa acataattgg gttattaaaa tgcctgaagc tgttccagaa
     7441 ggagtttctc gtggatttac cgctttggtt ccgggatttg ttgttgcatt tgttgttatc
     7501 tttatcaacg gtcttcttgt agcaatggga acagatattt ttaaagtcat tgcaattcca
     7561 tttggttttg tatccaatct gactaattcg tggattggtt taatgattat ttatctattg
     7621 actcaactac tttggattgt aggtatccac ggtgcgaaca ttgtttttgc atttgttagt
     7681 ccaattgctc ttgctaacat ggctgaaaat gctgctggcg ggcacttcgc tgttgcaggt
     7741 gaattttcta atatgtttgt aattgcaggt ggttctggtg caactttagg actatgttta
     7801 tatattgctt ttgcctctaa atctgaacag cttaaagcaa taggacgagc atctgtagtt
     7861 ccagccttat ttaatattaa tgaaccatta atttttggat tacctattat ctataatcca
     7921 gccttggcta taccatttat tttagcacca atggttactg ctactattta ttacgtagcg
     7981 aattctctaa actttattaa gccaattatc gcacaggttc catggccaac tccagtaggg
     8041 attggagctt tcttagggac agcagatctt cgagctgtat tagttgctct agtatgtgca
     8101 tttgcagcat tcctagtcta tcttccattc atccgtgtat atgatcaaaa attggtgaaa
     8161 gaagagcaag gtatctaata agtaaaaaag tatactcgat gatagaatcc atatagttta
     8221 aataatgagt gttaacatta gcagtgaaga gatcttttta agatattctt ctctgctttt
     8281 tcattttatt tttttgctat gtagggtatg aagcaaaata gaaagtagtt cgaatagttg
     8341 ataaacaggg aactgctgtt atttaaaaaa acaataaagt aaagtatgtt atcgtagaat
     8401 acgatacaat agtaaaaaag caaaaagaat gcgttttata tttgggtttg aggcttataa
     8461 aataggataa gcgtgctgaa aacttagata tgacaaacaa aataaaattt ttaaaagcta
     8521 cagagaaaca tggtataatg tatctaaagg aggtagcata tgtccttaga tatagataaa
     8581 gaaaagatga caatcatggg aatagctttt gaaaaccgat ccgtttttaa gagtgtttgg
     8641 tatgctttaa gtacaaatat gattgaagga tggcgaccta cggttagtga tgttgaaaaa
     8701 ttacgagatg aagctcttgc tctggggatg acttaatgaa gcgcaactgt tatgaatctt
     8761 atgactatgt tgatccggat aatttatata ccgatccggg ttcttcagtt ctaagaaata
     8821 agcaggaagg aaaaaagcac gtgagcttga atatcgtatg attgctagta agagtttgaa
     8881 attatttatc aatcctatct tagttaatag tttaaaagta gtttgtttca caactgcata
     8941 agcttagaaa agttgaaaag tgataactct ttaataaact cttggtttgt taaaagatat
     9001 tttgtccact acattttttc aattgactat tatttgtcat agatataaca gatagaacat
     9061 tgcattcaga ataatgaaaa acgcatcaaa aatggtgcgt tctgttttta tgctaccata
     9121 aaaggaggaa aacaaattga aaatttttaa gggagagttt tatcgaatct ctgtattaac
     9181 agacaagcta gtaaggttag aatactctcg aactggaaat tttgaggata gaacgacaca
     9241 acttatctat aatagagatt ttggccaagt ttcgttagat tatatcgaga catcaaatgt
     9301 actagatatt atgacggact attttcatct gcactttaat aaaggagaat ttaacgccga
     9361 aaatttattt atagaattaa aaggaaattt tgccgtatat ggtagtcgct ggtattttgg
     9421 tgaatctatt gaaacgttaa aaggaacagc tcggactctg gataaggcag atggagcaat
     9481 ctcgttagaa gatggaatta ttagccgaaa tggtatagcc ttattggatg attctcaagg
     9541 atttatttgg gatgaacaat ctggttatat tgagagagaa aatcaaattg acctgtattt
     9601 ctttgcctat gggcatgatt atagaggagc aatcagagac ttttaccatt tgactggttc
     9661 aacacccttg ttgccaagat atgctttagg caattggtgg agtagatatt ggccttatac
     9721 gtcggatgaa tacttggatt taatagacag atttgaaaca gagaaaattc cattatctat
     9781 cggtgtgtta gatatggatt ggcatataac tgacattcca gctcgttttg gaagtggctg
     9841 gacaggatat agttggaata aaaacttaat acctaatcca gaacagttat tgcaacaact
     9901 tcatgataga aagttaaaac tctctttaaa tgtccatcct gctgatggta tacgggctta
     9961 tgaagaagct tatcctcaag tcgccaaacg attagggtta aatgtagaac tagaagaacc
    10021 tgccattttt gattttttta atccctcttt tagggaagcc tactttaaag atgttcatta
    10081 tgagctagaa aagcagggag tagatttttg gtggattgac tggcaacaag ggactcaagg
    10141 catattggat ccactatggc ttttaaacca ttatcattat caggatagtt gtaaaaatgc
    10201 agaaggtggt ttgattttat caagatatgc aggtcctggt agccaccgct accctgttgg
    10261 tttttcaggg gacactatta ttagttggaa ttccttaaga tttcaacctt attttacagc
    10321 gacagcatct aatatcggtt atagttggtg gagccatgat atcggtgggc acatgctggg
    10381 ggattatgac gaagagctgc aaactagatg gctacagttt ggtgttttta gtccgatcac
    10441 tcgattacat agttctagaa gtccttttaa tagtaaagaa ccttggtttt tttcagaaac
    10501 aacatctaag attatgaaga aataccttcg tttgagacat cagatgattc cctatctata
    10561 taccatgaat gtaaagacac acgaggaagg tgccccatta atcagtccaa tctattattt
    10621 ctacccagag aatgatgaga gctataatgt tccaaaccaa tacttttttg gaacagaact
    10681 aatggtggct cccattgtag aaaagatgga cttggcattc caatctgcaa aagtggatgt
    10741 atggttccct gaaggtgaat ggtatgactt cttttcagag aaaaaatata caggtggtgt
    10801 gaagttgagt gtttatagag acatttcgac tatacctgtg tttgcaaaaa gtggtgcgat
    10861 cattcccttg gttggttctg agatagatat gggtgttgat ttacctgaag ttgtagattg
    10921 gtatgtattc ccaggcaaac aacattcttt tgaaatgctt gaagatcaaa atggtcaaag
    10981 atataaaaca agattatcaa tcgattggga aatggggatg gtagagttaa cattacaagg
    11041 agattctagt atcgttccaa gcaatagaag gcatagaatt cattttaaag gaacgaatgt
    11101 gtctataatt gaattaccaa ataagaatga tacagctaga tttgaatgta aagataataa
    11161 aacaatatct ttaaatgatg aagtttttag actactaaag acagcttctc ttccatatga
    11221 attaaaagat agattgttaa atcaattcat caatgcgaaa aactctcatg acttaatgaa
    11281 tatcttgcat catcaggata aggaattgag agggcgtttg ttggaaatga tatttactag
    11341 ccaaaactaa ttgatataat tagaaagtca tttgtttagt gtatatgaag attctgtatg
    11401 gtattcgtta tcactggtca cattgaaaat gtgaaataag cacctacaac atagacttta
    11461 caacacttca tgtttcatat catggggtgt ttttctattt aagtcaaagc caatcaaaaa
    11521 atctcactat tcatcaggtt aaaggaaacc taatcatagt gagattgtga attatagtag
    11581 agtttgtatc gcctcttcaa tttgttttgg gtctgttttt gaagaaaagc gttcaaagac
    11641 ttgcccatct cgaccgatga gaaacttagc gaaattccat tcgactcgtt ttcctagtgg
    11701 gccggatttc tggtctttta accagacata gagagggtct gcttccttac cgttgacctt
    11761 aatcttggca aaacgtggga aggtggtttg aaaatgtagg ctacagaagg cgttgatttc
    11821 ctctgcgctg ccgggtgctt gtcccataaa ctgattgcaa gggaaatcca atatttcaaa
    11881 gccctgatct tgatagcgtt catagagttc ttgaagtccc tggtactggg gcgttaaacc
    11941 acatccagta gcagtgttga caatcaagag aactttgcca cgatagctat ccaagggagt
    12001 tgcttggttg ttttggttca aaacggaaaa atcataaagt gaagtcatga gggcctcttt
    12061 tctttttcta cattgtaaca gtttttactt ttttcgtcga gtcggatgga agatattgtt
    12121 gaagaataag ccctcaatat gatagaaacc gtttacaaat aactttaaaa atggtataat
    12181 ttaattaaac cggtttactt agttgctata aatctctaat ttgagattta gttcctattg
    12241 attttacaat atgtttattg gagtgtatac atgcaaacaa aaacaaagaa gctcattgtg
    12301 agtttgtctt cacttgtttt atcaggattt ttattaaacc attatatgac agttggagcg
    12361 gaagaaacga ctacgaatac cattcagcaa agccagaagg aagttcagta tcagcaaagg
    12421 gatacaaaaa atttagttga aaatggtgat tttggtcaga cggaggacgg aagcagtccg
    12481 tggacaggaa gcaaagctca ggggtggtca gcttgggtag accagaagaa tagttctgca
    12541 gatgcctcaa ctcgagtcat tgaggctaag gatggggcta tcactatctc aagccatgag
    12601 aaattaaggg cagcgcttca ccgtatggtt cctattgaag ttaagaaaaa gtataaactg
    12661 cgtttcaaga ttaaaacaga taataaaatc gggattgcca aagttcgtat cattgaggaa
    12721 agtggtaagg acaagcgatt gtggaattct gcaacgacgt caggaacaaa ggactggcag
    12781 accattgaag cagactatag cccgacttta gatgttgata aaatcaagct ggagttattc
    12841 tatgaaacag gaactgggac tgtttccttt aaggatattg agctggtaga ggtagcagcc
    12901 cagctttctg aggattctca aacagataaa cagcttgagg aaaagattga tttaccaatt
    12961 ggaaaaaaac atgttttttc tcttgcggac tatacttata aggtagaaaa tcctgacgtt
    13021 gcttcagtca aaaatggaat tttagaacct cttaaggaag ggacaaccaa tgtcattgtc
    13081 agtaaagatg gcaaggaagt gaaaaagatt cctttgaaga ttctagcctc tgttaaggat
    13141 acatacacag accgtttgga tgactggaat ggcatcatcg ctgggaatca atactatgat
    13201 tctaaaaatg aacagatggc caaattaaac caggaattgg aaggaaaggt agctgatagc
    13261 ctatccagta tttcaagtca ggcggaccgc acctatttgt gggaaaaatt ttcaaattat
    13321 aaaacgtctg caaatctgac tgccacttat cggaaattgg aggagatggc caagcaagtg
    13381 accaatcctt cttctcgtta ttatcaagat gaaactgtcg ttcgaacagt cagggattcc
    13441 atggaatgga tgcataaaca tgtctacaat agtgaaaaga gcattgttgg gaactggtgg
    13501 gattatgaaa tcggtacacc tcgtgccatc aacaatacct tgtctctgat gaaagaatac
    13561 ttctctgatg aggaaattaa aaaatataca gatgtgattg aaaaatttgt accagatccc
    13621 gaacatttcc gaaagacgac tgataaccca tttaaggctc taggtggaaa cttagttgat
    13681 atgggaagag taaaagtaat agctggttta ctgcgtaagg atgatcaaga aatttcttct
    13741 accattcgct cgattgagca agtgttcaag ttggtagacc aaggtgaagg tttttatcaa
    13801 gatggatcct atatcgacca caccaatgtt gcctatacgg gtgcttatgg gaatgttttg
    13861 attgatggcc tgtctcaact gttgccagtc attcaaaaga ccaagagtcc aatcgataaa
    13921 gataaaatgc aaaccatgta ccactggatt gataaatcgt ttgctccttt gctggtgaat
    13981 ggagagctga tggatatgag tcgtggacgc tcgatcagtc gtgcaaatag cgaggggcac
    14041 gtggccgcag tagaagtact aagagggatt caccgaatag cggatatgtc tgaaggagaa
    14101 accaaacaac gtttgcagag tcttgtgaag accattgttc aatcggatag ttattatgat
    14161 gtctttaaga atttgaagac ttataaggat atcagtttga tgcaatcctt gttaagtgat
    14221 gcaggagtcg caagtgttcc aagaacaagt tacctatctg cctttaacaa gatggataaa
    14281 acagccatgt acaatgcaga gaaagggttt ggatttggct tgtcactctt ttccagtcgt
    14341 accttgaatt acgaacacat gaacaaggaa aataaacgtg gttggtatac gagtgatggg
    14401 atgttctatc tttacaatgg cgatttgagt cactatagcg atggctactg gccaacagtt
    14461 aatccatata agatgcctgg tacaacagag acggatgcta agagagcgga tagcgataca
    14521 ggtaaagttt taccgtctgc tttcgttgga acgagcaaac tagatgatgc caatgcgaca
    14581 gcaaccatgg atttcaccaa ctggaatcaa acattgactg ctcataagag ctggtttatg
    14641 ctaaaggata agattgcctt tttaggaagc aatatccaaa acacttcaac agatactgct
    14701 gcaactacaa ttgaccagag aaaactggaa tcaagtaatc catataaagt ctatgtcaat
    14761 gataaagaag cctcccttac agaacaagaa aaggattatc ctgaaaccca aagtgtcttt
    14821 ttagaatcgt ccgattcgaa aaagaatatt ggttactttt tctttaagaa gagttcaatc
    14881 agtatgagta aggctttgca aaagggagcc tggaaggata tcaatgaagg acagtcagac
    14941 aaggaagttg aaaatgaatt tcttactatt agtcaggctc ataagcaaaa tggagattct
    15001 tatggctata tgctcattcc taacgtggat cgtgccacct tcaatcaaat gataaaagag
    15061 ttagaaagta gcctcatcga aaataacgaa acccttcagt ctgtttatga tgccaaacaa
    15121 ggagtttggg gcattgtgaa atatgatgat tctgtctcta ctatttccaa ccaattccaa
    15181 gttttgaaac gtggagtcta taccattcga aaagaagggg atgaatataa gattgcctac
    15241 tataatcctg aaacccagga atcagctcca gatcaggaag tctttaaaaa gctagagcaa
    15301 gcagctcagc cacaagtaca gaattcaaaa gaaaaggaaa aatctgaaga agaaaagaac
    15361 cattcggatc aaaagaatct ccctcagaca ggagaaggtc agtcaatctt ggcaagtcta
    15421 gggttcttgc tacttggggc gttttattta ttccgtagag gaaagaacaa ctaatttgtt
    15481 catcatctag atgaattaca tgaaactgtg gaaaatagaa aaaatccgaa gaaggccaaa
    15541 tatcttcgga tttttctttt aaaaagggat aagttgatac ttatcctttt ttacttcatt
    15601 atgtgactat agcgttttga aactagaata ggacgtcata actgctaaaa gatttctata
    15661 aattcatttg attttcctaa tcaatttgtt cgtatcctat ttcactccac tatattagtc
    15721 cgtctcgctc cgtgaggtgc gagacaaaac aaccacccgc tatgcgggtg cgcgtcgaag
    15781 gctataccaa aaaactccaa acgcgataca ataaaggtgt tcaatccaat tgtaaagcga
    15841 aaggagaaaa aatatggcac aaaagactca tagtttatca tacacaaagt ggatgtgttc
    15901 tatcatattg tgttcacccc taagtataga cgaaaagtca tctataatca atatagaagt
    15961 agtttaggcg aaatatttca tcgcttgtgt agttataaag gtgttgaaat gatcgagggt
    16021 cacttaatgc cagaccatgt acacatgtta gtcagtattc cactaaggct aagtgtttcg
    16081 agtttcatgg ggtatttaaa aggcaaaagt gcactcatga tgtttgacaa acacgccaat
    16141 ctcaagtaca agtttgggaa tcggcatttc tgggcggaag gttattatgt aagtacagta
    16201 gggcttaata aagccacact taagaaatat agtcaagatt aaagaaatta tcgagtggat
    16261 gatttcttca cgagtatgaa aatttgagaa cgagtaaagt atgatatata gtaaaatgaa
    16321 ataagaacag gacaaaatcg atcaggacag tcaaatcgat ttttaacaat gttttagaag
    16381 tagaggtgta ctattccagt ttcaatctac tatagcacta gataaattga gtgtaaaaga
    16441 atatgaggat ccctttaggg atagtggtaa gtaataccaa agtctcttaa agaggcaagt
    16501 gacgagtcaa gagcaataag gcttgaacaa cgtgaaagcc agcgtcttta ggcgctggct
    16561 gatgatttgg gcttatagct ct
//
LOCUS       DBMVGT010000037        16292 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.037, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000037 DBMVGT010000000
VERSION     DBMVGT010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 16292)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16292)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16292
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.037"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..3273
                     /gene="addA"
                     /locus_tag="AC0DU4_001335"
     CDS             <1..3273
                     /gene="addA"
                     /locus_tag="AC0DU4_001335"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0016818 - hydrolase activity, acting on
                     acid anhydrides, in phosphorus-containing anhydrides
                     [Evidence IEA];
                     GO_process: GO:0000724 - double-strand break repair via
                     homologous recombination [Evidence IEA];
                     GO_process: GO:0006302 - double-strand break repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HIN4237288.1"
                     /translation="DSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLENEVFHEVFEA
                     HYQGKQKETFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWLSESFLKGFEK
                     ADFTSEKEKLTEQIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLILDEIGSLNQE
                     SDSQAYQAVLARVVAISKEKNGRALTNASRKADLKPLADAYNEERKTQFAKLGQLSDQ
                     ITILDYQERYHQDTWELAKTFQTFMSHFVEVYRQRKRQENAFEFADISHYTIEILENF
                     PQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQSIYRFRQADPQ
                     IFNEKFQRYAQNPQEGKLILLKENFRSSSEVLSATNDVFERLMDQEVGEINYDNKHQL
                     VFANTKLTPNPDNKAEFLLYDKDDTGEEEESQTETKLTGEMRLVIKEILKLHQEKGVA
                     FKEIALLTSSRSRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLDTLRVIHNPLQ
                     DYALVALMKSPMFGFDEDELARLSLQKAEDKVHENLYEKLVNAQKMASSQKGLIHTAL
                     AEKLKQFMDILASWRLYAKTHSLYDLIWKIYNDRFYYDYVGALPNGPARQANLYALAL
                     RADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKDAVELMTIHKSKGLEFPYI
                     FILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIKLSIPSLTYRQ
                     NEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLESKEYPAAKNGKLNSNTRL
                     QARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTREAIGELETKSPLQDSSQADNRQS
                     DTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDMEGVEIAGQGQSVG
                     KKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLTSLTETLKQVQTSQAVRD
                     KINLDKILAFFDTALGQEILANTDHLYREQPFSMLKRDQKSQEDFVVRGILDGYLLYE
                     NKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIEKYLILLGKDEVQVV
                     KV"
     gene            3443..4621
                     /locus_tag="AC0DU4_001336"
     CDS             3443..4621
                     /locus_tag="AC0DU4_001336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237289.1"
                     /translation="MTLPVRKSLHDAVLQASKADTWEQATKEWNEVSLIFNGIGRSNC
                     VCGNAIKYAYELFNGVTGQRLFPIGSDCVRHFHRLSLDQQLEEEEKLLRKVENLTRKA
                     QKKEKIKVNKSDFDERLLKWLWEKGVFKPNRGNQFAPERDYQLFLEVFQGGSWTKAEP
                     KKKARMEEVLEKCIKPFLLGKSDDQLYLVKLGKEKIDYEQELRIQAEKERKKRDKIAK
                     QYADNLVLAMGPAERAYQDYFGFTETLTQEERKWEKILFGKNRAERDIKAKQYQKELE
                     KDQRIASQDPIERKQKQTWLLNSYFRELPEEKARFSRLLLEYRKSGEVPFSTEYLSDH
                     LIDFFYKMKAFEFEIAPEQVRDFLKKSLQEDHRSSAQGSWIEGILLNCLKPFLERLVI
                     "
     gene            4830..10904
                     /gene="iga"
                     /locus_tag="AC0DU4_001337"
     CDS             4830..10904
                     /gene="iga"
                     /locus_tag="AC0DU4_001337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunoglobulin A1 protease"
                     /protein_id="HIN4237290.1"
                     /translation="MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQE
                     TAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSK
                     NERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLL
                     NYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDY
                     NVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQL
                     AEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEEI
                     QENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPSPRIVEKGTK
                     KTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGEPEVQPTLPEAVVSDKG
                     VPEVQPELPEAVVSDKGVPEVQPELPEAVVSDKGEPEQVAPLPEYKGNIEQVKPETPV
                     EKTKEQGPEKTEEVPVKPTEETPVNPNEGTTEGTSIQGAENPVQPAEESTTNSEKVSP
                     DTSSENTGEVSNKPSDSTTSVGESNKPEHNDSKNENSEKTVEEVPVNPNEGTVEGTSN
                     QETEKPVQPAEETQTNSGKIANENTGEVSNKPSDSKPPVEESNQPEKNGTATKPENSG
                     NTTSENGQTEPEPSNGNSTEDVSTKSNTSNSNGNEEIKQENELDPDKKVEDPEKTLEL
                     RNVSDLELYSLSNGTYKQHISLEQVPSNPNSYFVKVKSSSFKDVYLPVASISEERKND
                     KILYKITAKVEKLQQEIESRYKDNFPFYLAKKGTEETTNFTSFSNLVKAINQNLSGTY
                     HLGASLNANEVELSTDDKSYIKGTFTGQLIGEKDGKHYAIYNLKKPLFENLSGATVEK
                     LSLKNVAISGKNDIGSLANEATNGTKIKQVHVDGVLAGERGVGGLLAKADQSSIAESS
                     FKGRIVNTYETTDSYNIGGLVGHLTGKNASIAKSKATVTISSNTNRSDQTVGGLAGLV
                     DRDAQIQDSYAEGDINNVKHFGRVAGVAGNLWDRTSGDVRHAGSLTNVLSDVNVTNGN
                     AITGYHYTGMKVANTFSSKANRVFNVTLEKNEVVSKESFEERGTMLDASQIASKKAEI
                     NLITPPIVEPLSTSGKKDSDFSKIAHYQANRALVYKNIEKLLPFYNKATIVKYGNLVK
                     ENSILYQKELLSAVMMKDDQVITDIISNKQTANKLLLHYKDHSSEKFDLRYQADFANL
                     AEYSIGDSGLLYTPNQFLYHQDSIINQVLPELNRVNYQSDAVRNTLGISPEVKLTELY
                     LEEQFTKTKEHLAENLKKLLSSDAGLVTDNEVMTGYIIDKIKRNKEALLLGMSYLERW
                     YNFSYGQVNVKDLVMYHPDFFGKGNTSPLDTLIELGKSGFNNLLAKNNVDTYAISLAS
                     HHGTTDLFSTLENYRKVFLPDKTNNDWFKSQTKAYIVEEKSNIEEVKTKQGLVGTKYS
                     IGVYDRITSATWKYRNMVLPLLTLPERSVFVISTISSLGFGAYDRYRNKEHQANGDLN
                     SFVEKSAHETAERQRDHYDYWYRILDEKGREKLYRNILLYDAYKFGTNHTEGKATEVA
                     DFDSPNPAMKHFFGPVGNKVGHNGHGAYATGDAVYYMGYRMLDKDGAITYTHEMTHNS
                     DQDIYLGGYGRRSGLGPEFFAKGLLQAPDQPSDATITINSILKHSKSDSKEGERLQVL
                     DPTTRFKDATDLQKYVHNMFDVVYMLEYLEGKSIVKKLNVYQKIEALRKIENQYLTDP
                     ADGNDVYATNVVKNLTEDEAKKLTSFDSLIDNNILSAREYKAGTYERNGYFTIKLFAP
                     IFSALSGEKGTPGDLMGRRIAFELLAAKGFKDGMVPYISNQYEEDAKQQGQTINLYGK
                     ERGLVTDELVLKKVFDGKYKTWAEFKTAMYQERVDQFGNLKQVTFKDPTKPWPRYGTK
                     TINNVDELQKLMDEAVLQDAKERNYYYWNNYNPETDSAVHKLKRAIFKAYLDQTNDFR
                     RSIFENKK"
     gene            10948..16221
                     /gene="zmpD"
                     /locus_tag="AC0DU4_001338"
     CDS             10948..16221
                     /gene="zmpD"
                     /locus_tag="AC0DU4_001338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000054777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease ZmpD"
                     /protein_id="HIN4237291.1"
                     /translation="MSLLKKDKFSIRKIKGIVGSVFLGSLLFAPSVVGTSTYHYLDYS
                     TLTQTERVQLKQGRPDESKESYALVYEKDALPNTGSSQSIMTALGLLAIGSLIVIITK
                     DKKRKKIATFLIVGATGLVTLSTASALNLNANIHESGRDGVLQISGYRYVDYLELDDR
                     TVSPVEQPKVVTDKGEPEVQPALPEAVVTGKGKTEVQPTLPEAVVTEKGEPEVQPVLP
                     EAVVAEKGEPEVHEKPDYTQPIGANLVEPEVHEKLAYTEPVGTTGVDENGNLIEPPVN
                     DIPEYTEPISTVSEVASEREELPSLHTDIRTETIPKTTIEESDPSKFIGDNSVKQVGE
                     DGERQIVTSYEELHGKKISESVETVTILKEMKPEIIVKGTKERPKEKTAPVLTLTKVT
                     EDAMNRSANLNYELDNKDNAEISSIVAEIKDGDTVVKRVDLSKEKLTDAVQNLDLFKD
                     YKIATTMIYDRGQGSETFKLDERPLRLELKKVEIKNIASTNLVKVNDDGTETPSDFMN
                     EKPSEEDVKKMYLKITSRDNKVTRLTVDSIEEVTEEGQKLYKITAEAQDLIQHTDPTK
                     VRNKYVYYIEKPHPKEDNVYYNFKDLVDAMNTDKNGTFKLGADLNATGVPTPKKWYVD
                     GDFRGTLKSVEGKHYTIHNTERPLFQNIIGGTVTKVNLGNVNINMPWADRIAPIADTI
                     KGGAKIEDVKVTGNVLGRNWVSGFIDKIDNQGTLRNVAFIGNVTSVGDGGQFLTGIVG
                     ENWKGLVERAYVDANLIGKKAKAAGIAYWTQNSGDNHKVGVEGAVKKGIVKGTIQVES
                     PVEVGGAVGRLSHHGYIGEVVSMMKVKKGEIFYGSSDMNDDPYWVANNVRGNYVVNGV
                     SEGTISYARAKEHHRIKPISQSEADTKIMMLGITAQDFAINEPVVNRLNRLTRKEDEY
                     KSTQDYKVDRDLAYRNIEKLQPFYNKEWIVNQGNKLAEDSNLAKKEVLSVTGMKDGQF
                     VTDLSDIDKIMVHYADGTKEEMDVTKNADSKVKQVREYTIAGQNVVYTPNMVEKDRNQ
                     LIQDIKDKLASVQLISPEVRALMDARKKPEENTDERKNGYIKDLYLEESFAETKANLD
                     KLVKSLVENADHQLNSDEAAMKALVKKVDENKAKIMMALTYLNRYYDIKYGDMTIKNL
                     MMFKPDFYGKSVDLLDFLIRIGSSERNIKGDRTLDAYRDMIGGTIGKSELHGFLDYNM
                     RLFTNDTDLNDWFIHAAKNVYVSEPQTTNPDFVNKRHRAFDGLNNGVHNRMILPLLTL
                     KNAHMFLISTYNTMAYSSFEKYGKYTEEARNEFKKEIDKVAHAQQTYLDFWSRLALPS
                     VRDQLLKSENRVPTPVWDNQNYSGIKGINRMGYDEKKVPIAPIRELYGPTWKFHNTNW
                     NMGAMASIFPNPNNNDQVYFMGTNMISPFGISAFTHETTHVNDRMLYFGGHRHRQGTD
                     VEAYAQGMLQTPSSIGHQGEYGALGLNMAYHRENDGDQWYNYDPDKLQTREDIDRYMK
                     NYNEALMMLDHVEADAVLPQLNGDNSKWFKKIDREMRRNLGDGLNNLVAPHQWDNVRD
                     LNQEESSKKLSSINDLIDNNFMTKHGNPGNGRYRPEDFRPNSAYVNVNMMAGIYGGNT
                     SQGAPGSLSFKHNAFRMWGYYGYDKGFTSYVSSKYQGEADKQNQGRLGDDFIIKKVSN
                     NQFSNLEDWKKYWYHDVKSRAEKGFTEITIDGQTIHNYNELKDLFDKAVTEDLKKAGN
                     YSNTENLKSKVFKALLKNTDGFFNPLFKKDI"
BASE COUNT         5703 a         2894 c         3358 g         4337 t
ORIGIN      
        1 gactctttca cacaaaaatt ccttggcaaa catggttatc tgcttgatat tgcacctaat
       61 ttccgtattt tacaaaacca aagcgagcaa cttcttctcg aaaacgaagt ctttcatgag
      121 gtctttgaag cgcattacca aggtaaacag aaagagacct ttagtcattt gctgaaaaac
      181 tttgctgggc gtggcaagga cgaacggggt ctgcgccagc aggtctataa aatctatgac
      241 ttcctccaat ccaccagtaa tcctcaaaag tggctgagtg aatctttcct caaaggcttt
      301 gagaaagctg attttaccag tgaaaaagaa aaactgactg agcaaatcaa acaagccctt
      361 tgggatttgg aaagcttttt ccgttaccat ctggataacg atgccaagga gtttgcaaag
      421 gctgcctatt tagaaaatgt tcagttaatt ctggatgaaa ttggctccct aaatcaggag
      481 tccgatagtc aggcttatca ggcagtgctt gcgcgtgttg tcgccatctc taaggagaaa
      541 aacggtcgag ctctgactaa tgccagtcgt aaggctgatt tgaagcccct ggctgatgcc
      601 tacaacgaag agagaaagac ccagtttgct aaactaggac aattatcaga ccagataacc
      661 attctcgact atcaagaacg ttatcatcaa gacacatggg aactagctaa aaccttccaa
      721 acctttatga gtcattttgt ggaggtttat cgtcagcgca aacgccagga aaatgccttt
      781 gaattcgctg atatcagcca ttacaccatt gagattttag agaatttccc acaagttcgt
      841 gagtcttatc aggagcgctt ccatgaagtc atggtcgatg agtatcagga taccaaccat
      901 attcaagaac ggatgctgga attgttgtct aatggccaca atcgctttat ggtgggagat
      961 atcaagcaat ccatctatcg tttccgtcag gcagacccgc agattttcaa tgagaaattc
     1021 caacgctatg cgcaaaatcc ccaagaaggc aagctcattc tcctcaagga aaatttccgt
     1081 agtagttcag aagtgctgtc agcaaccaat gatgtctttg aacgtctcat ggaccaagag
     1141 gtcggcgaaa tcaactatga taacaagcac cagcttgttt ttgccaatac caaactgact
     1201 cccaatccag acaacaaggc agaatttctc ctctacgaca aggacgatac aggtgaggaa
     1261 gaagagagtc aaacagaaac gaaactaaca ggcgaaatgc gcttagttat caaggagatt
     1321 ctgaaacttc atcaagaaaa aggtgttgcc tttaaggaaa ttgcccttct gacctccagc
     1381 cgcagtcgta atgaccagat tctcctcgcc ctgtctgagt acggaattcc tgtcaaaact
     1441 gacggagagc aaaacaatta tctccaatcc ctagaagtgc aagtcatgct agacactctt
     1501 cgtgtcattc acaatcccct gcaagactac gccttggttg cccttatgaa gtctccaatg
     1561 tttggttttg atgaggatga gctagcacgt ttgtcccttc agaaagcaga ggataaagtc
     1621 cacgaaaatc tctatgagaa actggtcaat gcacaaaaaa tggcaagtag tcaaaaaggc
     1681 ttgattcaca cagctctagc tgaaaaacta aagcaattca tggatatcct agcttcttgg
     1741 cgcttgtatg ccaaaaccca ttctctctat gacttgattt ggaagattta caacgaccgt
     1801 ttttattatg actatgttgg ggctttgccg aatggtcctg ctaggcaggc caatctctat
     1861 gccctagcac tgcgtgctga tcaatttgaa aagagcaatt tcaaaggttt gtcgcgtttt
     1921 attcgtatga ttgaccaagt cttagaagcc cagcacgatt tggcaagcgt agccgtcgca
     1981 ccgccaaaag atgcagtaga gctcatgacc atccacaaga gtaaagggct ggagtttcct
     2041 tacatcttta tcctcaatat ggatcaagat ttcaacaagc aagactctat gtcagaagtc
     2101 attctcagtc gtcagaatgg tcttggtgtc aaatatattg ccaagatgga gacaggggca
     2161 gtagaagacc actatcctaa aaccatcaaa ctctccattc ctagtctgac ctataggcag
     2221 aacgaagagg aattacagct agcaagctat tctgagcaga tgcgtttgct gtatgttgct
     2281 atgacgcggg ctgagaaaaa gctctatctt gtcggcaagg gttctcgtga aaagctggaa
     2341 tccaaggaat acccagcagc caaaaatggg aaactaaata gcaatactag actgcaagca
     2401 cggaatttcc aagattggct ttgggctatc agtaaagtgt ttactaagga caagctcaac
     2461 tttagttatc gttttattgg cgaagatcag ttgaccagag aagctatcgg agagttggaa
     2521 accaagagtc ctctccaaga tagctcccaa gcagacaatc gtcagtcaga taccatcaaa
     2581 gaagctctgg aaatgctgaa ggaggtggaa gtttataata ctcttcaccg cgcagctatt
     2641 gaacttccta gtgttcaaac cccaagtcaa atcaagaaat tctacgaacc agttatggat
     2701 atggaaggtg tcgagattgc tggtcaaggt cagtcagtag gcaagaaaat cagcttcgat
     2761 ttgccagatt tttcaaccaa agaaaaggta actggagctg agattggtag tgctactcac
     2821 gaactcatgc agagaattga cctcagccag caactaaccc ttactagcct aacagaaaca
     2881 ctcaaacaag ttcaaactag ccaagctgtc agagacaaga tcaatcttga taaaattctt
     2941 gctttctttg acacagcact cggtcaggaa attcttgcta ataccgacca tctctatcgc
     3001 gagcaacctt tctccatgct caaacgagac caaaagagtc aggaagactt tgttgtccgt
     3061 ggtatccttg atggctatct gctttacgaa aacaaaattg ttctgttcga ctacaagaca
     3121 gaccgctatg atgaaccaag tcaactcgta gaccgctatc gtggtcagtt agctctatac
     3181 gaagaggctt tatcacgagc ctattcgatt gaaaatattg aaaaatactt gattttactc
     3241 ggtaaagacg aggttcaagt tgtaaaagta taacttatac tcttcgaaaa tctcttcaaa
     3301 ccacgtcagc ttcgccttgc tgtatatatg gttactgact tcgtcagttc tatccacaac
     3361 ctcaaaacag tgttttgagc tgactgcggc tagctttcta gtttgctctt tgatttttat
     3421 tgagtattag aaaggagacc tcatgacact tccagttaga aaatccctgc acgatgcagt
     3481 tttacaggct tcgaaagcgg atacttggga acaagctacc aaggaatgga atgaagtttc
     3541 cttgattttt aacggtatcg gccgtagcaa ttgtgtctgt ggaaatgcca tcaaatacgc
     3601 ttatgaactc tttaacggtg tcacaggcca acgcctcttt ccaattggta gcgactgtgt
     3661 tcgtcatttt catcgattgt cccttgacca gcaattggaa gaggaagaaa aactgctcag
     3721 aaaggttgaa aatctaacca gaaaagctca gaaaaaggaa aaaatcaagg tcaataaaag
     3781 tgactttgac gagcgacttc taaaatggct ctgggaaaaa ggtgttttca aacccaatcg
     3841 tggcaatcaa tttgcgcctg agagagacta ccagcttttc ctagaagtct ttcagggagg
     3901 aagttggacc aaggcggaac caaagaaaaa ggctcggatg gaagaagtcc ttgaaaagtg
     3961 tatcaaaccc tttttacttg ggaaatcgga tgaccaactc taccttgtca agctaggcaa
     4021 ggagaaaatt gactacgaac aagaactccg tatccaggca gagaaagaac gcaagaagag
     4081 ggataaaatc gccaagcaat atgcagacaa tctggttcta gccatgggac ccgcagagcg
     4141 tgcttatcaa gattactttg gctttacaga gaccctgact caagaagaac gcaagtggga
     4201 aaaaattctt tttggtaaaa atagagcaga acgggatatc aaggccaaac aataccaaaa
     4261 agagctggaa aaagaccaac gaattgccag tcaggatcca attgaaagaa aacagaagca
     4321 gacttggctc ctcaattcct attttcgtga gcttcctgaa gaaaaagctc gattttctag
     4381 gctcttatta gaatatcgaa aaagtggtga agtacccttt tcaactgaat acctgtccga
     4441 tcatctcatc gactttttct ataaaatgaa agcctttgaa tttgaaatcg caccagaaca
     4501 agtccgagat tttctaaaaa aaagcctgca ggaagaccat cgctcatcag cacaaggaag
     4561 ctggatagaa ggaattctcc tcaactgcct caaaccattt ttagaacgat tagtgatatg
     4621 agtaacacct accgtgtaaa tttcatggta ggtgttattg tacctcaaaa taatataaaa
     4681 caaagtatga aagcgcatct caattttaag acttttttgt aaattaagag tataattaag
     4741 gtatactgcc ttttctatag ataatatata atacactaat ataataaagg tctttgtaac
     4801 atatataaat tttatttcaa ggaggaataa tggaaaagta ttttggtgaa aaacaagagc
     4861 gtttttcatt tagaaaatta tcagtaggac ttgtatctgc aacgatttca agtttatttt
     4921 ttatgtctgt attagctagt tcatctgtgg atgctcaaga aactgcggga gttcactata
     4981 aatatgtggc agattcagag ctatcatcag aagaaaagaa gcagcttgtc tatgatattc
     5041 cgacatacgt ggagaatgat gatgaaactt attatcttgt ttataagtta aattctcaaa
     5101 atcaactggc ggaattacca aatactggaa gcaagaatga gaggcaagcc ctagttgctg
     5161 gtgctagctt agctgctctg ggaattttaa tttttgctgt ttccaagaaa aaggttaaga
     5221 ataaaacggt attacattta gtattggttg cgggaatagg aaatggtgtc ttagtttcag
     5281 tccatgcttt agaaaatcat cttttgctaa attacaatac ggactatgaa ttgacctctg
     5341 gagaaaaatt acctcttcct aaagagattt caggttacac ttatattgga tatatcaaag
     5401 agggaaaaac gacttctgat tttgaagtaa gtaatcaaga aaaatcagca gccactccta
     5461 caaaacaaca aaaggtggat tataatgtta caccaaattt tgtagaccat ccatcaacag
     5521 tacaagctat tcaggaacaa acacctgttt cttcaactaa gccgacagaa gttcaagtag
     5581 ttgaaaaacc tttctctact gaattaatca atccaagaaa agaagagaaa caatcttcag
     5641 attctcaaga acaattagcc gaacataaga atctagaaac gaagaaagag gagaagattt
     5701 ctccaaaaga aaagactggg gtaaatacat taaatccaca ggatgaagtt ttatcaggtc
     5761 aattgaacaa acctgaactc ttatatcgtg aggaaactat agagacaaaa atagattttc
     5821 aagaagaaat tcaagaaaat cctgatttag ctgaaggaac tgtaagagta aaacaagaag
     5881 gtaaattagg taagaaagtt gaaatcgtca gaatattctc tgtaaacaag gaagaagttt
     5941 cgcgagaaat tgtttcaact tcaacgactg cgcctagtcc aagaatagtc gaaaaaggta
     6001 ctaaaaaaac tcaagttata aaggaacaac ctgagactgg tgtagaacat aaggacgtac
     6061 agtctggagc tattgttgaa cccgcaattc agcctgagtt gcccgaagct gtagtaagtg
     6121 acaaaggcga accagaagtt caacctacat tacccgaagc agttgtaagc gataaaggcg
     6181 taccagaagt tcaacctgaa ttacccgaag cagttgtaag cgataaaggc gtaccagaag
     6241 ttcagcctga attacccgaa gcagttgtaa gtgataaagg tgaaccagag caggtagcac
     6301 cattgccaga atataagggg aatattgagc aagtaaaacc tgaaactccg gttgagaaga
     6361 ccaaagaaca gggtccagaa aaaacggaag aagttccagt aaaaccaaca gaagaaacac
     6421 cagtaaatcc aaatgaaggt actacagaag gaacctcaat tcaaggagca gaaaatccag
     6481 ttcaacctgc agaagaatca acaacgaatt cagagaaagt atcaccagat acatctagcg
     6541 aaaatactgg ggaagtatcc aataaaccta gtgattcgac aacctcagtt ggagaatcaa
     6601 ataaaccaga acataatgac tctaaaaatg aaaattcaga aaaaactgta gaagaagttc
     6661 cggtaaatcc aaatgaaggc acagtagaag ggacctcaaa tcaagaaaca gaaaaaccag
     6721 ttcaacctgc agaagaaaca caaacaaact ctgggaaaat agctaacgaa aatactggag
     6781 aagtatccaa taaacctagt gattcaaaac caccagttga agaatcaaat caaccagaaa
     6841 aaaacggaac tgcaacaaaa ccagaaaatt caggtaatac aacatcagag aatggacaaa
     6901 cagaaccaga accatcaaac ggaaattcaa ctgaggatgt ttcaaccaaa tcaaacacat
     6961 ccaattcaaa tggaaacgaa gaaattaaac aagaaaatga actagacccc gataaaaagg
     7021 tagaagatcc agagaaaaca cttgaattaa gaaatgtttc cgacctagag ttatacagtt
     7081 tgtcaaatgg tacttataaa caacacattt cgttagagca agttccaagc aatccaaata
     7141 gctactttgt taaagtgaaa tcttcttcat tcaaagatgt atacctacca gtagcatcaa
     7201 tatcagagga aagaaaaaat gataaaatcc tttataaaat cacagcaaaa gtagagaagc
     7261 ttcagcagga gatagaaagc agatataaag ataattttcc cttctatcta gctaagaagg
     7321 gaacagaaga aacaacaaac tttacttcct ttagtaatct ggtcaaagct ataaaccaaa
     7381 atctctctgg aacctatcat ttaggagcta gcctgaatgc taacgaagtg gagcttagta
     7441 ctgatgataa atcctatatc aagggaacct ttactggtca gttgattggt gaaaaagatg
     7501 gtaagcatta tgctatttac aacttgaaaa agcctctttt tgaaaacttg agtggtgcta
     7561 cagtagaaaa actgagtcta aaaaatgttg ctatttcagg gaaaaatgat attggttcac
     7621 tggcaaatga agctacgaat ggcacaaaga ttaaacaagt tcatgttgat ggtgttctgg
     7681 ctggagaacg tggtgtcggt ggtttgttgg ctaaggcaga ccaatcaagc atcgcagaga
     7741 gcagtttcaa gggaagaatt gtcaatacct atgaaacgac tgattcctac aatattggcg
     7801 gtctggtcgg tcatttaaca ggaaaaaatg cgtctattgc taaatccaaa gcgacagtaa
     7861 ccatttcgtc aaacaccaat aggtcagatc agactgtcgg tggtcttgca ggtctagtag
     7921 accgagatgc acagatccaa gatagctatg ctgaaggtga tatcaacaat gtcaagcact
     7981 ttggtagagt cgctggagtg gcaggcaatt tgtgggatcg aacttctggt gatgttaggc
     8041 atgctggaag tttgaccaat gttctcagcg atgttaatgt aacaaacgga aatgccatca
     8101 ctggatacca ctatacagga atgaaggtag ctaatacatt tagtagtaag gctaatagag
     8161 ttttcaatgt cactttagag aagaatgagg tcgtcagcaa agaatccttc gaggaaagag
     8221 gaacaatgct agatgcttct caaattgcaa gcaaaaaagc agaaatcaat cttatcactc
     8281 caccaatagt ggaacccctc tcaacaagcg gtaagaaaga cagtgatttt tctaagatag
     8341 cccattatca agccaaccgt gctttggttt ataagaacat tgaaaaattg ttacctttct
     8401 ataacaaggc gaccatcgtg aaatacggaa acctggttaa ggagaacagt atcttatatc
     8461 aaaaagaact cttgtctgca gttatgatga aggatgacca agtaatcaca gatattattt
     8521 ccaacaaaca gactgcaaac aaactcttgc ttcactacaa ggaccattca tctgaaaagt
     8581 ttgatctcag gtaccaggct gattttgcca atttggcaga atatagcatt ggagatagtg
     8641 ggcttctcta tacgccaaat caattcttgt atcatcaaga ttctattatt aaccaagtgc
     8701 tgcctgaatt gaatcgagta aattatcaat cagatgctgt tagaaataca cttggaattt
     8761 caccagaagt gaagctaacg gagttatatc ttgaagaaca atttaccaaa acgaaagagc
     8821 atctagcaga gaacttgaaa aaacttttat catctgatgc aggtttagta acagacaatg
     8881 aagttatgac aggatatata atagataaaa ttaaacggaa taaggaagcc ttacttcttg
     8941 gaatgagtta tttagaacgt tggtataact ttagctatgg tcaagtgaat gtcaaagacc
     9001 tagttatgta tcatccggac ttctttggta aaggaaatac ttcaccatta gatactctga
     9061 ttgagttagg taaatctggc tttaacaatc ttcttgctaa aaacaatgtc gatacttatg
     9121 ctatcagcct tgccagccat catggaacga cagatttgtt tagcacgttg gaaaattacc
     9181 gaaaagtctt tctaccagat aaaaccaata atgactggtt taaatcacag actaaggctt
     9241 acattgtcga agaaaaatcc aatatcgaag aggtgaaaac gaagcaagga ctagttggca
     9301 ctaagtattc tattggtgtc tatgaccgta tcactagtgc cacatggaaa taccgtaata
     9361 tggtactacc tctacttacc ttgccagaaa gatccgtatt tgtcatttca accatatcta
     9421 gtctaggttt tggtgcttat gatcgctatc gtaataaaga acatcaagca aatggtgatc
     9481 ttaatagctt tgttgaaaag agtgctcacg aaacagcaga gcgtcaacga gatcactatg
     9541 attattggta tcgtattcta gatgaaaaag ggcgtgaaaa gctttatcga aatatcttgc
     9601 tttatgatgc ctataaattt ggaactaatc atactgaagg aaaggctaca gaagtagcag
     9661 attttgatag tccaaatcct gcaatgaaac atttctttgg acctgttgga aataaggttg
     9721 gacataatgg acatggtgct tatgctacag gggatgcagt atattatatg gggtatcgca
     9781 tgctagataa ggatggagct attacgtata ctcatgagat gacgcataat tcagatcaag
     9841 atatttatct tggtggttat ggaagaagaa gtggacttgg acctgagttc tttgctaaag
     9901 gcttactaca agcaccagac caaccaagtg atgcaacgat tactatcaat tctatattga
     9961 aacattcaaa atctgatagt aaagaaggag aacgattaca agtacttgat ccaactacga
    10021 gatttaaaga cgcaacagat cttcaaaaat acgtccacaa tatgtttgat gttgtttata
    10081 tgttggaata tctcgaaggt aaatctattg ttaagaaatt aaatgtatat cagaaaatag
    10141 aagctctcag aaaaatcgag aaccaatatc taacagatcc tgctgatgga aatgatgttt
    10201 atgctactaa tgttgtgaaa aatttgactg aagatgaagc taaaaaattg acgagctttg
    10261 atagtttgat tgacaataac attctttcgg ctcgtgagta taaggctggc acttatgaga
    10321 gaaatggcta ctttactata aaactctttg caccaatctt ttcagcattg agcggtgaga
    10381 aaggaactcc aggtgacctt atgggacgaa ggatagcttt tgaacttcta gctgctaaag
    10441 gatttaaaga tggtatggta ccatatattt ccaaccaata cgaagaagat gctaaacaac
    10501 aagggcaaac tatcaatctt tatggtaaag aacggggctt ggtgaccgat gagcttgttt
    10561 tgaaaaaggt atttgatggt aagtataaaa cttgggcaga atttaagaca gctatgtacc
    10621 aagaacgggt ggatcagttt ggaaacttga agcaggtgac ctttaaagat ccgacaaaac
    10681 catggccaag atatggcaca aagactatca ataatgtgga tgaattgcag aaactaatgg
    10741 atgaagctgt tttgcaggat gcaaaagaac gtaattatta ttattggaat aactataatc
    10801 cagaaacgga cagtgccgtc cataagttga agagagcaat ctttaaagcc tatcttgacc
    10861 aaacaaatga ttttagaaga tcaatttttg agaataaaaa atagtgttta ctattaggaa
    10921 ataaaaagtg aatgtggagg attagaattg tcattattaa aaaaagataa attttccatt
    10981 cggaaaataa agggtattgt tggttcggta ttcttgggga gtcttttatt tgcaccgtca
    11041 gttgttggta catcgactta tcattactta gattatagta ctttgacaca aactgaacgt
    11101 gttcaactca aacaaggtag acctgatgaa tcaaaagagt catatgcttt ggtttatgaa
    11161 aaagacgcat taccaaacac aggaagttct caatctatta tgactgcatt gggtttgtta
    11221 gctatcggga gtcttattgt gattatcaca aaagataaaa agaggaaaaa aatcgctaca
    11281 tttttgattg taggggcgac aggtttagtt acactatcaa ctgcttcagc acttaatttg
    11341 aatgctaaca tccatgagtc tggacgtgat ggtgtgttgc aaatttctgg ttacagatat
    11401 gttgattact tggagcttga tgatagaact gtttctccag ttgagcaacc caaagttgtg
    11461 accgacaaag gcgaaccaga agttcagcca gcgttaccag aagctgttgt aactggaaaa
    11521 gggaaaactg aagtacaacc gacattacca gaagctgttg tgactgaaaa aggggaaccg
    11581 gaagtacaac cagtgttacc agaagctgtt gtggctgaaa aaggggaacc agaagttcat
    11641 gagaagcctg actatacgca accaataggt gcaaaccttg ttgagcctga agttcatgag
    11701 aaactagcat acactgaacc tgtaggtaca acaggagtag atgaaaatgg aaacttgatt
    11761 gagccacctg ttaacgatat tccagagtat actgaaccaa tatctacagt ttcagaagtt
    11821 gcatcagaaa gagaagagtt gccttcttta cataccgata ttcgtacaga gactattcct
    11881 aaaaccacta tagaagaatc tgatcctagc aaatttatag gcgataattc tgttaaacaa
    11941 gttggtgagg atggcgaacg tcaaattgtt actagctatg aagagttaca tggcaaaaaa
    12001 atcagcgagt cagttgaaac agtaacaatt ttgaaagaaa tgaagcctga aattattgta
    12061 aaaggtacaa aagaaagacc aaaagaaaaa acggctcctg ttttaacctt gaccaaagta
    12121 acagaagatg ctatgaatcg ttctgccaac ttaaattatg agcttgataa taaagataat
    12181 gctgaaatat caagtattgt agctgaaatt aaagatggtg atacagtagt taaaagggtt
    12241 gatttatcta aagaaaaatt aactgacgct gtacaaaatt tggatttgtt taaagattat
    12301 aagattgcaa caacaatgat ttatgatcgt ggtcaaggtt ctgaaacgtt taaactggat
    12361 gaaagacctc tgcgtttgga gttgaaaaag gtcgaaatta aaaatatcgc atctactaat
    12421 ttagtgaagg taaatgatga tggtactgaa acacctagtg attttatgaa tgaaaaacct
    12481 tcagaagaag atgttaaaaa aatgtactta aaaatcacta gtcgcgataa taaggtaact
    12541 cgtttaactg tagactctat tgaagaagtg actgaagaag gtcaaaaact ttacaaaata
    12601 actgctgaag cacaagattt gattcaacac acagacccaa cgaaggttcg taataagtat
    12661 gtttattata tagaaaaacc ccatcctaaa gaagataatg tctactataa ctttaaagat
    12721 ttagtagatg ctatgaatac tgataaaaat ggtacattta aacttggtgc agatttgaat
    12781 gccactggtg ttccaacacc taagaaatgg tatgttgacg gcgactttag aggtacattg
    12841 aagagtgtag aggggaaaca ttatactatc cacaacacgg agcgtccgtt attccagaat
    12901 attattggtg gtacagtaac caaagtaaat ctgggaaatg taaatatcaa tatgccatgg
    12961 gcagaccgca tcgcaccgat tgctgacact attaaaggtg gcgctaaaat tgaagatgtc
    13021 aaagtgactg gtaacgtatt aggtagaaac tgggtatctg gatttattga taagattgac
    13081 aaccaaggta cactcagaaa tgtagccttt atcggaaatg tgacatctgt aggtgatggt
    13141 ggtcaattct tgaccggtat cgttggtgag aactggaaag gactagtcga acgtgcgtat
    13201 gttgacgcaa atcttattgg caagaaagcc aaggctgctg gtattgctta ttggacacaa
    13261 aacagtggtg acaatcataa agttggtgtc gaaggtgcag tcaagaaagg aattgtgaag
    13321 ggtaccattc aggtagaaag tcctgttgaa gtcggcggtg ctgttggacg tttgagtcat
    13381 catggttata tcggggaagt cgtatctatg atgaaagtta agaagggtga aattttttat
    13441 ggttctagtg atatgaatga tgacccatat tgggtggcga ataatgtacg aggaaattat
    13501 gtagttaatg gtgtgagtga aggtacgata tcttatgctc gtgctaaaga acaccatcgt
    13561 atcaaaccaa tttcacagtc agaagcagat actaaaatta tgatgttagg tattacagca
    13621 caagattttg ctatcaacga acctgtggtc aatcgcttaa accgtttaac cagaaaagaa
    13681 gatgaatata agtcaaccca agactataaa gtagatcgag atctggctta tcgtaatatt
    13741 gagaaacttc aaccatttta taacaaagaa tggattgtca accaaggtaa caaacttgca
    13801 gaagattcaa acttagctaa gaaagaagtc ctttctgtta cgggtatgaa ggatggacag
    13861 tttgtaactg acttatcaga tattgataag attatggttc actatgctga tggtactaaa
    13921 gaagaaatgg acgtcactaa gaatgctgat tctaaagtga aacaagttcg tgaatatacc
    13981 atcgctggac aaaacgttgt ttatacacca aatatggttg agaaagaccg taaccaattg
    14041 attcaagata tcaaagataa gttggcgtca gttcaattga tttctcctga agtacgtgct
    14101 ttgatggatg cacgtaagaa accagaagaa aatactgatg aacgtaagaa tggttatatt
    14161 aaagaccttt acttagaaga aagctttgct gaaacgaaag ctaatcttga taaattggtt
    14221 aaatccttag ttgaaaatgc agatcatcaa ttaaatagtg acgaagcggc tatgaaagca
    14281 cttgttaaga aggtggatga aaataaagct aaaatcatga tggctctgac ttatctcaat
    14341 cgttactatg atatcaagta tggggatatg actatcaaga acttgatgat gtttaaacct
    14401 gatttctatg gtaaatcagt tgaccttctt gatttcttga ttcgaattgg atcaagtgag
    14461 agaaatatca aaggtgacag aactttggat gcttatcgtg atatgattgg tggaactatt
    14521 ggtaagtctg aattacatgg attcttagat tacaatatgc gtctcttcac taacgatact
    14581 gatttaaatg attggttcat ccatgcagct aagaatgtat atgtatcaga acctcaaaca
    14641 acgaacccag attttgttaa taaacgacat cgtgcatttg atggtttgaa caacggtgtt
    14701 cataatcgta tgattctacc tctattaact cttaagaatg cacatatgtt cttgatttca
    14761 acttacaata caatggctta tagttctttt gagaaatatg gtaagtatac agaagaagct
    14821 agaaatgaat tcaaaaaaga aattgataag gttgcacatg ctcaacaaac atacttagac
    14881 ttctggtcac gtttagcatt gccaagcgta cgtgaccaat tactcaagag tgagaatagg
    14941 gtaccaactc ctgtgtggga taaccaaaac tatagtggta ttaaaggaat aaaccgtatg
    15001 ggttatgatg agaagaaagt accaattgcg ccaattcgtg agttatatgg tccaacttgg
    15061 aaattccata ataccaactg gaatatggga gctatggcat ctattttccc aaatcctaat
    15121 aacaatgacc aagtttattt catgggaaca aatatgatta gtccgtttgg tatttcagcc
    15181 tttactcatg aaactacaca cgttaatgat agaatgcttt acttcggtgg tcatagacac
    15241 cgtcaaggta cagacgtcga agcctatgct caaggtatgc tacaaactcc gtcaagtatt
    15301 ggtcaccaag gtgaatatgg tgctttaggt ttgaacatgg cttatcatcg tgaaaatgat
    15361 ggtgaccaat ggtataacta tgaccctgat aagcttcaaa ctcgtgaaga tatcgatcga
    15421 tatatgaaaa actataatga agcactgatg atgctagatc atgtagaagc agacgccgta
    15481 cttccacaat tgaatggtga taatagcaag tggttcaaga aaattgatag agaaatgcgc
    15541 agaaatcttg gggatggttt gaataactta gtagcaccgc accaatggga caacgttcgt
    15601 gacttaaatc aagaagagag ttctaagaaa ttatcaagta ttaacgattt gattgataat
    15661 aatttcatga ccaaacacgg aaatccaggt aacggacgtt atagaccaga ggattttaga
    15721 ccaaactcag cttacgtaaa tgtcaatatg atggcaggaa tttacggtgg gaatacgagt
    15781 caaggtgctc ctggttcatt atcgttcaaa cataatgcct tccgtatgtg gggttattat
    15841 ggatatgaca aaggtttcac tagttatgta tctagcaaat atcaaggtga agctgataaa
    15901 caaaaccagg gtagattagg tgatgatttc attatcaaaa aagtttcaaa caaccaattc
    15961 tcaaatcttg aagattggaa gaaatattgg tatcatgatg tgaaatccag agctgaaaaa
    16021 ggattcacag agattacaat tgatggacaa accattcaca actataatga actgaaagac
    16081 ttattcgaca aagctgtcac agaagacctc aagaaagctg gaaactactc aaatactgag
    16141 aatttgaaat ccaaagtctt caaagctctt cttaaaaaca cagacggttt ctttaatcca
    16201 ttgttcaaaa aagacattta aaccccaatt atgcacccca aatctaaaaa ccatccagaa
    16261 tccttgcctt agcttagatc ctggatggtt tc
//
LOCUS       DBMVGT010000038        15959 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.038, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000038 DBMVGT010000000
VERSION     DBMVGT010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 15959)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15959)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15959
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.038"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1269)
                     /locus_tag="AC0DU4_001339"
     CDS             complement(<1..1269)
                     /locus_tag="AC0DU4_001339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000907130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HIN4237292.1"
                     /translation="MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKAFLDHG
                     LKEVFEDVLPISNFTDTMELEFVGYEIKEPKYTLEEARIHDASYSAPIFVTFRLINKE
                     TGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGS
                     TVIPNRGAWLELESDSKDITYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSELVR
                     NTVEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPRRYDLAAVG
                     RYKINKKLNVKTRLLNQTIAEPLVDPETGEILVEAGTIMTRSVIESIESHLDGDLNKI
                     VYIPNDAAVVTEPVVLQKFKVIAPTDPDRVVTIIGNANPDDKVRTVTPADILAEMSYF
                     LNLAEGLGRVDDIDHLGNRRIRAVGELLANQ"
     gene            1685..1755
                     /locus_tag="AC0DU4_001340"
     tRNA            1685..1755
                     /locus_tag="AC0DU4_001340"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1717..1719,aa:Cys,seq:gca)
     gene            complement(1953..3284)
                     /locus_tag="AC0DU4_001341"
     CDS             complement(1953..3284)
                     /locus_tag="AC0DU4_001341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin family protein"
                     /protein_id="HIN4237293.1"
                     /translation="MEDPSSQNLLLQFVLLFILTVLNAFFSATEMAMVSLNRARVEQK
                     AEEGDRRYIRLLKVLENPNHFLSTIQVGITLITILSGASLTDTLGRVIASWLGNGETA
                     QAVATFLSLAFLTYISIVFGELYPKRIALNLKDALAIRTAPVIIGIGKLVSPFVWLLA
                     ASTNFLSHLTPMSFDDADEKMTRDEIAYMLTNSEETLDADEIEMLQGVFSLDELMARE
                     VMVPRTDAFMVDIQDDSQAIIQSILKQNYSRIPVYDGDKDNVIGIIHTKSLLKAGFVD
                     GFDNIVWKRILQDPLFVPETIFVDDLLKELRNTQRQMAILLDEYGGMAGLVTLEDLLE
                     EIVGEIDDETDKAAIDVHQIGEDTYIVQGTMTLNDFNNYFDVELESDDVDTIAGYYLT
                     GVGTIPTTEKLSYELVSQNKQFILTNDKVKNGRVTKVKVQITEVEIEEETE"
     gene            complement(3575..4399)
                     /gene="endA"
                     /locus_tag="AC0DU4_001342"
     CDS             complement(3575..4399)
                     /gene="endA"
                     /locus_tag="AC0DU4_001342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-entry nuclease EndA"
                     /protein_id="HIN4237294.1"
                     /translation="MNKKTRQTLIGLLVLLLLSTGSYYIKQMQSAPNSPKTNLSQKKQ
                     ASEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIVNGNKTNLDAKVSSKPYADNKTK
                     TVGKETVPTVANALLSKATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
                     LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRV
                     RYRVTLYYASNEDLVPSASQIEAKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ"
     gene            complement(4438..4626)
                     /locus_tag="AC0DU4_001343"
     CDS             complement(4438..4626)
                     /locus_tag="AC0DU4_001343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HIN4237295.1"
                     /translation="MNKKSSYVINRLLLVIIVLILGTLALGIGLMVGYGILGKGQDPW
                     AILSPAKWQELIHKFTGN"
     gene            complement(4619..5902)
                     /gene="murA"
                     /locus_tag="AC0DU4_001344"
     CDS             complement(4619..5902)
                     /gene="murA"
                     /locus_tag="AC0DU4_001344"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008760 - UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase activity [Evidence IEA];
                     GO_process: GO:0019277 - UDP-N-acetylgalactosamine
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HIN4237296.1"
                     /translation="MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQ
                     NVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVL
                     GPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHI
                     YMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETIT
                     ITGVEKLHGTTHNVVQDRIEAGTFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVE
                     VIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTVAKGESTMVETVFEN
                     RFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETV
                     VGKLVHLDRGYYGFHEKLAQLGAKIQRIEASDEDE"
     gene            complement(5926..6156)
                     /locus_tag="AC0DU4_001345"
     CDS             complement(5926..6156)
                     /locus_tag="AC0DU4_001345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014017351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1146 family protein"
                     /protein_id="HIN4237297.1"
                     /translation="MVQLLFTLSSHMLFIYVSFYLLKDLVRWEKVLKVTDENTRKVRL
                     LVAFFSIVIGYILSSFFISLYHLWQEALRGLL"
     gene            complement(6214..7251)
                     /locus_tag="AC0DU4_001346"
     CDS             complement(6214..7251)
                     /locus_tag="AC0DU4_001346"
                     /EC_number="3.4.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SepM family pheromone-processing serine
                     protease"
                     /protein_id="HIN4237298.1"
                     /translation="MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLK
                     INDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFTDIRSAQETTGGSSDVEFMRINQ
                     FYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
                     DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVIS
                     NVPISFSTAGIGGPSAGLMFSLAIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGID
                     KKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAKTIKTDMKIVPVKTL
                     QDAIDYLKNNP"
     gene            complement(7235..7723)
                     /gene="coaD"
                     /locus_tag="AC0DU4_001347"
     CDS             complement(7235..7723)
                     /gene="coaD"
                     /locus_tag="AC0DU4_001347"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004595 - pantetheine-phosphate
                     adenylyltransferase activity [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HIN4237299.1"
                     /translation="MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQ
                     GFLPIENRKRGLEKALGHLENVEVVASHDELVVDVAKRLGATCLVRGLRNASDLQYEA
                     SFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPESILEEIRNEK
                     KD"
     gene            complement(7713..8252)
                     /gene="rsmD"
                     /locus_tag="AC0DU4_001348"
     CDS             complement(7713..8252)
                     /gene="rsmD"
                     /locus_tag="AC0DU4_001348"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0052913 - 16S rRNA
                     (guanine(966)-N(2))-methyltransferase activity [Evidence
                     IEA];
                     GO_process: GO:0031167 - rRNA methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HIN4237300.1"
                     /translation="MKIVSGIYGGRPLKTLEGKTTRPTSDKVRGAIFNMIGPYFEGGR
                     VLDLYAGSGGLSIEAVSRGMSSAVLVERDRKAQTIVAENIQITKEIGKFQLLKMDAER
                     ALEQVSGEFDLVFLDPPYTKEQIVADIEKMAERELFSEDVMVVCETDKAVELPEEIAC
                     LGIWKEKIYGISKVTVYVR"
     gene            complement(8317..9309)
                     /gene="asnA"
                     /locus_tag="AC0DU4_001349"
     CDS             complement(8317..9309)
                     /gene="asnA"
                     /locus_tag="AC0DU4_001349"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016502595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004071 - aspartate-ammonia ligase
                     activity [Evidence IEA];
                     GO_process: GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HIN4237301.1"
                     /translation="MKKSFIHQQEEISFVKNTFTQYLKDKLEVVEVQGPILSKVGDGM
                     QDNLSGVENPVSVKVLQIPDATYEVVHSLAKWKRHTLARFGFGEGEGLFVHMKALRPD
                     EDSLDATHSVYVDQWDWEKVIPNGKRNIVYLKETVEKIYKAIRLTELAVEARYDIESI
                     LPKQITFIHTEELVERYPDLTPKERENAICKEFGAVFLIGIGGELPDGKPHDGRAPDY
                     DDWTSESENGYKGLNGDILVWNESLGGAFELSSMGIRVDEETLRRQVEITGDEDRLEL
                     EWHKSLLNGLFPLTIGGGIGQSRMAMFLLRKRHIGEVQTSVWPQEVRDTYENIL"
     gene            complement(9420..10103)
                     /locus_tag="AC0DU4_001350"
     CDS             complement(9420..10103)
                     /locus_tag="AC0DU4_001350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="HIN4237302.1"
                     /translation="MNHTIIHDRAGLNQFYAKVYAFVGLGIGLSALVSGLMLTVFQSQ
                     LVYFLMQGRLWLTIATFAELALVFVASSMASRNSPAALPVFLLYSVLNGFTLSFVVAF
                     YTPGTVLSAFVSSALLFFVMAAVGIFTKKDLSGIGRAMMAALIGLLIAMVVNIFLASG
                     FFDYMISVAMVLVFSGLIAWDNQKIRLAYEQSQGRVATGWVVSMALSIYLDFINLFLS
                     ILRIFGRND"
     gene            complement(10159..10899)
                     /locus_tag="AC0DU4_001351"
     CDS             complement(10159..10899)
                     /locus_tag="AC0DU4_001351"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TrmH family RNA methyltransferase"
                     /protein_id="HIN4237303.1"
                     /translation="MTIITSKANSVVKNTKKLHQKKYRKSAYLIEGWHLFEEAVQAGV
                     TIEKIFTLENYRDQLATFSQTVWVSEDILLDLADSQTPQGIVAVVQREEVGQADLSQG
                     KFLFLEDVQDPGNVGTIIRTADAAGFTGVIVSDKSADIYSLKTLRSMQGSHFHLPIYR
                     MTSQALLDETKKVAIPVLATTLSKDSVDYRELPSIENFVLVMGNEGQGISPLMAESAD
                     QLVHISMKGQAESLNVAVAAGILIFHLS"
     gene            10933..11211
                     /locus_tag="AC0DU4_001352"
     CDS             10933..11211
                     /locus_tag="AC0DU4_001352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001174612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acylphosphatase"
                     /protein_id="HIN4237304.1"
                     /translation="MQKVRMIAQGRVQGVGFRWGVYSLALEIGGITGRVWNNDDGTVE
                     ILAQADSSAIMAKFIQEIRKGPTPFSKVSYLDVKLSNFPPYSDFKIAN"
     gene            11289..12215
                     /gene="yidC"
                     /locus_tag="AC0DU4_001353"
     CDS             11289..12215
                     /gene="yidC"
                     /locus_tag="AC0DU4_001353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HIN4237305.1"
                     /translation="MKSIKRFAFSAMGVAMLLVLTGCVNVDKTTGQPTGFIWNTIGAP
                     MAEAIKYFATDKGLGFGVAIIIVTIIVRLIILPLGIYQSWKATLHSEKMNALKHVLEP
                     HQTRLKEATTQEEKLEAQQALFAAQKEHGISMFGGVGCFPILLQMPFFSAIYFAAQHT
                     EGVAQASYLGIPLGSPSMILVACAGVLYYLQSLLSLHGVEDEMQREQIKKMIYMSPLM
                     IVVFSLFSPASVTLYWVVGGFMMILQQFIVNYIVRPKLRKKVREELAKNPPKASAFSK
                     PSGRKDVTPEQPTAITSKKKHKNRNAGKQRSR"
     gene            complement(12290..13084)
                     /gene="pflA"
                     /locus_tag="AC0DU4_001354"
     CDS             complement(12290..13084)
                     /gene="pflA"
                     /locus_tag="AC0DU4_001354"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001288284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate-lyase-activating protein"
                     /protein_id="HIN4237306.1"
                     /translation="MSEETIDYGQVTGMVHSTESFGSVDGPGIRFIVFLQGCHMRCQY
                     CHNPDTWAMESNKSRERTVDDVLTEALRYRGFWGNKGGITVSGGEALLQIDFLIALFT
                     KAKEQGIHCTLDTCALPFRNKPRYLEKFDKLMAVTDLVLLDIKEINEEQHKIVTRQTN
                     KNILACAQYLSDIGKPVWIRHVLVPGLTDRDDDLIELGKFVKTLKNVDKFEILPYHTM
                     GEFKWRELGIPYSLEGVKPPTADRVKNAKKLMDTESYQDYMKRVHG"
     gene            complement(13210..14460)
                     /locus_tag="AC0DU4_001355"
     CDS             complement(13210..14460)
                     /locus_tag="AC0DU4_001355"
                     /EC_number="4.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000856498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008836 - diaminopimelate decarboxylase
                     activity [Evidence IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate decarboxylase"
                     /protein_id="HIN4237307.1"
                     /translation="MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWN
                     KGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVELLMSHKLDFLGSEIMFSSNNTPD
                     KEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPGEAK
                     FGMTKDQLFEAFAILKEKGAKTFGIHSFLASNTVTHLYYPELARQLFELAVEIKEKLG
                     ISLDFINLSGGIGVNYRPDQEPNDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFM
                     LAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHISNVTHPDGPAEAVDV
                     VGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGK
                     ARQIRRAERPEDYFATLYGFDFEE"
     gene            complement(14527..15354)
                     /gene="purR"
                     /locus_tag="AC0DU4_001356"
     CDS             complement(14527..15354)
                     /gene="purR"
                     /locus_tag="AC0DU4_001356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004242125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA];
                     GO_process: GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA];
                     GO_process: GO:0045982 - negative regulation of purine
                     nucleobase metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HIN4237308.1"
                     /translation="MKLRRSDRMVVISNYLINNPYKLTSLNTFAEKYESAKSSISEDI
                     VIIKRAFEEIEIGHIQTVTGAGGGVIFTPSISSQDAKEMVEDLRTKLSESDRILPGGY
                     IYLSDLLSTPAILKNIGRIIAKSFMDQKIDAVMTVATKGVPLANAVANVLNVSFVIVR
                     RDLKITEGSTVSVNYVSGSSGDRIEKMFLSKRSLKAGSRVLIVDDFLKGGGTVNGMIS
                     LLREFDSELAGVAVFADNAQEEREKQFDYKSLLKVTNIDVKNQAIDVEVGNIFDEDK"
     gene            complement(15621..>15959)
                     /locus_tag="AC0DU4_001357"
     CDS             complement(15621..>15959)
                     /locus_tag="AC0DU4_001357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260511.1"
                     /note="catalyzes the exonucleic cleavage of mRNA yielding
                     nucleioside 5'-phosphates; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HIN4237309.1"
                     /translation="PDQTEYTVRGNLLGHIALIDSEITKTVMELGIDDTKEEVVLLRH
                     VILSHHGLLEYGSPVRPRIMEAEIIHMIDNLDASMMMMSTALALVDKGEMTNKIFAMD
                     NRSFYKPDLD"
BASE COUNT         4650 a         3683 c         2984 g         4642 t
ORIGIN      
        1 ttggttggca agcaattcac caaccgcacg gatacgacga tttccaaggt ggtcgatatc
       61 atctacacgg ccaagtcctt cagccaagtt gaggaagtag ctcatctcag caaggatatc
      121 tgcaggagtc accgtacgaa ccttgtcatc tgggttagca ttaccaatga tcgttacgac
      181 gcgatctgga tcagttggag caataacctt gaatttttga agaacaacag gctcagtcac
      241 aacggctgca tcgtttggga tgtagacaat cttgttcaag tcgccatcca aatggctttc
      301 aatgctttca atcacgctac gagtcataat cgtaccagct tctaccaaga tttctccagt
      361 ttcagggtct accaatggct ctgcaatggt ttggttgagc aaacgtgttt taacattgag
      421 ttttttattg attttgtaac gaccaactgc tgccaagtca taacgacgtg ggtcaaagaa
      481 gcgagctaca agcaagctac gtgagctttc agccgtctta ggctcacctg gacgaaggcg
      541 ttcgtaaatt tctttcaagg cttcgtctgt acgagagtcc attggattct tgtggatatc
      601 tttttcaaca gtgttgcgaa ccaattcgct gtctccaaag atatcaaaga tttcatcatc
      661 acctgagaaa ccaagagcac gaaccaaggt tgtaaatgga atcttacgag tacggtcaat
      721 acgagtgtag gtgatatctt ttgagtcgct ttcaagttcc aaccaagctc cacggttagg
      781 gataacagtt gaaccatagc ccaccttacc atttttgtct actttgtcgt taaagtaaac
      841 acctggtgag cggaccaact gagaaacgat aatacgttca ccaccattga tgatgaaagt
      901 acccatttct gtcatgattg ggaaatcacc aaagaaaact tcttgggtct tgatttcgcc
      961 tgtttcttta ttgatcaaac ggaaggttac aaaaattggt gctgagtagc tagcatcgtg
     1021 gatacgagct tcttctagcg tgtattttgg ttccttgatt tcatatccaa caaattccaa
     1081 ctccattgtg tctgtgaagt ttgaaattgg caatacatct tcaaacactt ccttaagacc
     1141 gtggtctagg aaagctttga atgagtcagt ttgaatttca atcaaatttg gtaagtcaag
     1201 aacttctttg attcttgaaa aactacgacg ggtacgatgt ttcccgtatt gaacgtcatg
     1261 tcctgccaag atgattctcc tttgtaaata agttccaagc cttgtcaatc aggcttttct
     1321 aatcgtcata tggttgtaaa ccccttatca ccgtgtcctc ttgacgaatt ttcagaatct
     1381 ttaagcctct gttacaaatg ctcataatct tgaaaaaaag cacaaaaaga gcagctaaat
     1441 ctgacttttt cagaagattt aactgctgtg agccttgtct ggacaatatt tcagacaaaa
     1501 cctacgacaa atgattaccc atattatacc ctatttagct agatttttca aggggtttca
     1561 gtaggttttt ggtaaatttt ttcccataga aaacttggca tcacattcga atcacgctat
     1621 ggtacaaaaa actgaaaaaa ctattgactg aaaatcattt tcaaggtata ataataaacg
     1681 ttaaggcggt atagccaagt ggtaaggcac ggctctgcaa aagcttgatc gtcggttcaa
     1741 atccgtctac cgccttctat aacttgattt atcaggtttc aaatgaacag aaagcccaat
     1801 ttgaagggct ttttttattt tccctcgaat aaatacgtat aactttaaaa acttttggag
     1861 cgagtttgtg gcagagttct ttccatggca taattccctt ttgaaatcaa ttgaaaaaag
     1921 cttcgtcacg cctggtgaca aaagcctcta gtttattctg tttcttcttc tatttcgact
     1981 tctgtgattt ggacttttac cttggtaaca cgtccattct tcactttatc attggttaag
     2041 ataaactgtt tgttttggct gaccaattca tagctgagtt tctcagtcgt tggaatggtt
     2101 cccactcctg tcaaataata accagcgatg gtatcaacgt catcactttc cagctcaaca
     2161 tcaaagtaat tattgaaatc attgagggtc atagttcctt gaacaatgta ggtatcctcg
     2221 ccaatctgat gaacatctat tgctgctttg tccgtttcat catcaatttc accaacaatt
     2281 tcctctaaga ggtcttccaa agtcactaaa ccagccatac caccgtattc atccagcaag
     2341 attgccattt gtctttgggt atttcgcagt tcttttagca agtcatccac aaaaatagtt
     2401 tcaggtacaa aaagtggatc ttgtaaaatt ctcttccaaa caatattgtc aaaaccgtcc
     2461 acaaagcctg ccttaaggag actcttggtg tgaatgattc caattacatt gtccttatcc
     2521 ccatcataaa ccgggatacg agaataattt tgttttaaaa tactttggat aatggcttga
     2581 ctatcatcct gaatatccac cataaaggca tccgttcgag gaaccataac ctctcgtgcc
     2641 atcagttcat cgagcgaaaa gacaccttgt agcatctcaa tctcatcagc atccaatgtt
     2701 tcttcactat ttgtcagcat ataggcaatt tcatcacggg tcattttttc atccgcatca
     2761 tcgaatgaca taggagtcaa atggctcaag aaattggtcg aagcagctaa aagccaaaca
     2821 aaaggactga ctagttttcc gatcccaatg ataaccggcg ctgtacgaat tgccaaggca
     2881 tcctttagat taagagcgat tctcttagga tataattccc caaaaacgat ggaaatatag
     2941 gtcaaaaatg ccaaggatag aaaagttgcc acggcttgtg ctgtttcgcc attcccaagc
     3001 caagaggcaa tcacacgtcc tagagtatca gttaaactcg cccctgataa gattgtaatc
     3061 agggtgattc ctacctgaat ggttgataaa aagtggttag gattttctag taccttcagc
     3121 aggcggatgt agcgtctgtc tccttcttcc gccttttgtt caactcgggc acgattaaga
     3181 gaaaccatgg ccatttctgt ggctgagaaa aaggcattta ataccgtcaa gataaacaat
     3241 aaaacaaatt gtagcaacaa attctgacta cttgggtctt ccatagttct tctcctaaaa
     3301 tagtatctta tcctttatta tatcacaaaa tttaatccaa tacatattat ttttttctta
     3361 gcgtaacttc catctctctc ccaaaactgg aagttagtct aagacggatt tccactgatt
     3421 tcacgcgttt ttctcatact aaaagctagg ttgtgggaaa ctggaagtta gttttagaag
     3481 ttactatttt ttcttagtac ctattctagc cctgcttaaa ctagtaaaaa gaactcctac
     3541 atccataagt gacataggag tttaggctta tcttttactg agttacagtt acttctccag
     3601 ttcggtaatc cagttgaagt cccttttgaa cattgggaac tagaacattg aattccaatt
     3661 ctccatccga agacttggct tcaatctgtg aagctgaggg aactaaatcc tcgtttgaag
     3721 cgtagtaaag ggttacacgg taacggacac gcttgttttg atccaaggct ttacgcacct
     3781 tgctttcata gtagttttga ccagtcgaat actcggcttg tgcctgattt gcccaggctg
     3841 tctgaacagc aatgttttta ggattgcttg ttgaggcatc aaaaccatcc aaaccaccga
     3901 ttaaggcata gcctaacaaa tgacctctat cgactgcatg ggtataagag ccctttagat
     3961 tcttgacctg atgccaacct ggaggagtcc aagaagttga accattccca gtttctttac
     4021 gattcttgta ctgacgagtg gccttagaca agagggcatt agctacggtt ggaacagttt
     4081 ccttgcccac tgtctttgtt ttattgtcag cgtagggctt acttgaaacc ttggcatcta
     4141 gatttgtttt attaccattg acgataaaag cacctgagcc attccactcc agactcccct
     4201 ttatttgact cttgactgcg tctgttaaga cactctctgc caatgcttga ctaggagctt
     4261 cagacgcttg ttttttctga ctaagattgg ttttgggact attaggtgcc gactgcatct
     4321 gcttgatata atagctccct gtagacaaaa gcaataacac tagcagtccg attagtgtct
     4381 gtcttgtttt tttgttcata tttctcctta tctttagaaa aaggctggtt ctccagccta
     4441 atttcctgta aatttatgaa tcaattcctg ccattttgct ggagacagga tagcccatgg
     4501 atcttgaccc ttgcccaaga ttccataacc taccattaga ccgattccta gagccagagt
     4561 acctaaaatc agtactatga tgactaaaag taaacgattg attacgtagc ttgatttctt
     4621 attcatcttc atcgcttgcc tcaatccgct gaatcttagc acctagctgc gccaacttct
     4681 catggaaacc gtagtaacct ctatccaagt gaaccaattt accgaccaca gtttctccct
     4741 gtgctaccaa acctgtcaaa atcaaggctg cactggcacg aaggtcagtt gaaagaactt
     4801 ctgctccctg caaaggctgt ccaccaacaa tacgagctgt atcacggata atctcagaat
     4861 gcaagcccat gcggcgcatc tcttctaggt gttggaaacg attttcgaaa actgtctcca
     4921 ccatggttga ttcgcctttt gcaactgtca tcaaggctgt aaattgagcc tgcatatctg
     4981 ttggaaatcc tgggtggggc aaggttttca catgaacagc ttttagattt tctagttgag
     5041 aacgaacacg aattccttcg tcttcttcaa ttacttcaac acccatttca agtaacttgg
     5101 caatcaaggg acggttgtgc tcccagacag cgtctcgaat caagacatca ccaccagtca
     5161 tggcagcagc taccataaag gttcctgctt cgatacggtc ttggactaca ttgtgagtcg
     5221 taccatgaag tttctcaaca ccagtaatgg ttatagtctc tgtaccagca cctttgacct
     5281 tggctcccat ttcattaagg agaatggcta agtcaacaat ctcaggctca cgcgcagcat
     5341 tctcaatcac tgtcacccca tcagccagag tcgctgccat catcaagttc tgcgttgcac
     5401 caacacttgg aaagtccata tagatatgag caccatgcaa gcgttctgcc ttggcttcga
     5461 tgtaaccagc tgtctgacta atcttaaccc ccatagcttc cagacctttc aaatgaagat
     5521 caataggacg gctaccaatc gtacaaccac ctggcatgga taccttggca tgacccacac
     5581 gggcaaggat tggccctaat acaacgatgg aggcgcgcat cttgctgaca tacttgtaag
     5641 gggcttcctc agtgatgtcg ccagtagcat ccaccttgac aagatgagct tcctcatcaa
     5701 agtcaacctt ggcattcaaa ccaccaacta cctgattcat aataaagaca tccgacaaaa
     5761 tcggaacatt ctgcaagacg gtctttcctt cacttgctag aatagtcgct gccaacaagg
     5821 gtaagactgc attttttgct ccctcgatcg tcacgcttcc taccagacga ttatcgccac
     5881 cttgaaccac aattttatcc atactcgttt cctttactct tgatttcata ataatcctct
     5941 aagcgcttct tgccacaaat gatacaggct aataaagaaa gaactcagga tgtagcctat
     6001 gacaatgcta aaaaaggcta ctaataaacg aacttttctt gtattctcat ctgtcacttt
     6061 taaaaccttc tcccatctaa caagatcctt taaaaggtaa aaactcacat aaataaagag
     6121 catatgacta cttagagtga ataataattg aaccatttga ctattatacc atcttctctg
     6181 tttgtgcgct agtttggaaa cttcactcaa aaattaggga ttgtttttca agtaatcaat
     6241 cgcatcttgt agggttttaa cgggcacgat tttcatatcc gtcttgattg ttttagccgc
     6301 ttctagggct gtttggtagt tgtttttcgc gtccggatgc gccttttgtt cttcttcgct
     6361 aacagggtta tcaggagcaa agaaaatagc agcacctgcc ctagccgaag ctacaacctt
     6421 cttatcaata cctccaatgt ctcccacatt accatcgcgg tcaatggtac ctgtaccggc
     6481 aacaatacga ccattacgaa gatctgggtg agctatttga gtatagatag ctagactaaa
     6541 catgagacca gcacttggac cgccaatacc agctgttgaa aagctaattg ggacattgct
     6601 gattacctct gtacggtcaa tcaagccgat tccaattcca tttttgccat tttccaaggt
     6661 gataatcttt ccttctgcag acttggtttg cccatcctct tcataggtga ccttgacgga
     6721 atcccctaat ttttgagaac tgacgtaatc aatcaagtct ttggaactat caaaggtctg
     6781 atcattgact gctgtgactg tatcagagat attgagaatc cctttaaagg ttgaattatc
     6841 cgtcacattc aaaacataaa ctccaaagta cttgagttcg atatccttac cagctgtttt
     6901 tagtccttga tacttggcca tattttgcga tgtttgcatg tagaattgat tgattcgcat
     6961 aaattcaaca tcggaagaac cacctgtagt ctcctgagca ctacgaatat ctgtaaaagg
     7021 tgtcaaccaa gcataaatca tatgagctaa agtggcatgt tgaacaccaa ccgtaacgaa
     7081 ttgataggca ccagcttcct tatcttctgt gtcatttatt ttaaggactt ggcgaatatc
     7141 ttccgaacca cctggaacct ctatataata aggcaagggc actacaaatg ccaagaaagt
     7201 cacaatcaag gccgcaatga cgtataaggg ccatctaatc ttttttttca tttcttattt
     7261 cctccaaaat actctcggga acatagcagg caatatcctg accaaacttc aaaagctctc
     7321 taacgcctga tgaactgata tagagatgtt caggtcgact atgtaaataa atagtctcta
     7381 tatcagaaga cagctgatga ttgtagtaat caaaactggc ttcatattgc aaatccgacg
     7441 cattcctcaa accacgcact agacaagtag cacccaatct ttttgcaaca tcgaccacca
     7501 attcatcatg agaagccacg acttcaacat tttccagatg tcccaaagcc ttttctagcc
     7561 cccgtttacg attttcgata ggaagaaatc cttgtttgtg gggattaaaa aaaataccga
     7621 catagagctt atcaaagagt ctgctcgccc gttcaatgat atccagatgc ccatttgtca
     7681 tcggatcaaa tgagcctgtg aataagccaa tcttatctga catagactgt caccttacta
     7741 attccataaa tcttttcctt ccagataccc agacaggcaa tttcttctgg aagttcaacg
     7801 gccttatccg tctcgcacac aaccataaca tcttcagaaa aaagctctct ctcagccatt
     7861 ttttcaatat ctgctacgat ttgttccttg gtatagggag ggtctaagaa aacgaggtca
     7921 aattccccag atacctgttc caatgccctt tctgcatcca tcttgaggag ttgaaatttt
     7981 ccaatttcct tggttatctg gatattttca gccacgatgg tctgagcctt acggtctcgc
     8041 tccaccaaaa cagcactgga catgccacgc gatactgctt cgatagataa accaccacta
     8101 cctgcataaa ggtccaagac tcgtccccct tcaaagtagg gaccaatcat gttaaaaatg
     8161 gctcccctaa ccttatccga agtaggtctt gtcgtcttgc cttctagtgt cttgagggga
     8221 cgtcccccat agattcctga tacgattttc atactgttta ttataccaaa ttatagacaa
     8281 aaagagaaag aaaaccgaac cttgcggttc gattctctac aaaatatttt cgtaagtatc
     8341 gcggacttct tgaggccaaa cacttgtttg cacttctccg atgtgtctct tgcgaagtag
     8401 gaacatggcc atacgagatt gtccaattcc tccaccgatt gtcaatggga atagaccatt
     8461 caacaaagac ttgtgccatt ccaattccaa gcggtcttca tcacctgtaa tttccacctg
     8521 acgtctaaga gtttcttcat ctacacgaat tcccatagaa gacaactcaa aggctccacc
     8581 taaagactca ttccagacaa gaatatcacc atttagaccc ttgtagccat tctcagactc
     8641 gcttgtccag tcatcatagt ctggtgcacg tccatcgtgc ggtttaccat ctggcaactc
     8701 gccaccgata ccaatcaaaa agacggctcc aaattcttta caaatcgcat tttcacgttc
     8761 tttcggtgtc aagtctgggt agcgttctac caattcttct gtatggataa aggtgatttg
     8821 ttttggcaag atagactcga tgtcatagcg ggcttcaaca gctagctcag tcaggcgaat
     8881 agccttataa atcttctcaa ctgtttcttt tagataaacg atgttacgct taccatttgg
     8941 gataaccttc tcccagtccc actggtcaac ataaacagag tgggttgcat ccaaggaatc
     9001 ctcatctgga cgaagggctt tcatgtggac aaagagaccc tctccttcac caaagccaaa
     9061 acgagccaag gtgtggcgtt tccatttagc aagtgagtgc accacttcat aagtagcatc
     9121 agggatttgg agaaccttga ccgatactgg attttccaca ccagacaggt tgtcctgcat
     9181 tccgtcaccg accttactca agataggacc ttgaacttcg acaacttcta gcttatcttt
     9241 caaatactgg gtaaaagtgt ttttgacaaa ggaaatttct tcttgttgat ggataaaact
     9301 tttcttcata gacaactcct caaaaattta ataaacgtat tatacaccta tttccaagaa
     9361 aagaaaagag aaaatttaaa aaaatcagtg tcactcaaaa cactgatttc atagaccttt
     9421 tagtcattgc gaccaaagat acgtagaata cttaggaaaa gattgataaa atcaagatag
     9481 atgctgagag ccattgacac cacccaacct gtcgctacac gaccttgtga ttgttcatag
     9541 gcgaggcgaa tcttttggtt atcccaagca atcaaccctg aaaaaaccaa aaccatggct
     9601 acgctaatca tataatcaaa gaagccacta gccaagaaaa tattgactac catagcaatc
     9661 agtaaaccaa tgagagctgc catcattgct cgaccaatcc cactcaagtc tttcttggta
     9721 aagataccaa ctgccgccat gacaaagaag agaagggcgc tcgatacaaa ggcagataaa
     9781 actgtacccg gagtatagaa agccaccaca aaactaaggg taaagccgtt taaaacggag
     9841 taaagtaaaa atactggaag agcagctgga ctatttcttg aagccatgct actggcaacg
     9901 aaaaccaaag ccaactccgc aaaagtagca atggtcaacc agagacgccc ctgcatcaaa
     9961 aagtaaacca actgagactg aaagaccgtc aacataaggc ctgataccaa agcagatagt
    10021 ccgattccca gaccaacaaa ggcataaacc ttagcgtaaa attgattgag acctgcacgg
    10081 tcatgtataa tagtgtgatt catccatttc tccttttctg tgaacatctt tccttgatta
    10141 taacaaaaaa agttaaaatt agcttaaatg gaagattaaa ataccggctg caaccgcaac
    10201 attcaaactc tcggcctgcc ccttcatgct aatatggacc aactggtctg cactttcagc
    10261 cataagggga ctaattcctt gaccctcatt tcccataact agtacaaaat tttctataga
    10321 aggcagttct ctgtaatcaa cagaatcttt agatagggtt gttgctagca ctgggatagc
    10381 taccttttta gtttcgtcaa gaagcgcttg actagtcatc cggtaaatgg gcagatggaa
    10441 atgactacct tgcatggaac gtagggtttt gagactgtag atgtctgccg acttatctga
    10501 aacaatcact cctgtaaaac ctgctgcatc cgcagttcga atgatagttc ctacattacc
    10561 aggatcttgc acatcttcca aaaacaagaa cttgccctga ctcaaatcag cttgtcctac
    10621 ttcttctctt tgaaccacgg caacaattcc ctgtggagtc tgagaatccg ccaaatctag
    10681 caaaatatcc tctgacaccc agacagtttg cgaaaaagta gctaactgat ctcgataatt
    10741 ttctagggta aagattttct caatcgtcac tccagcttga acagcttctt caaacaagtg
    10801 ccagccttca atcaaatagg ctgacttgcg gtattttttt tggtgtaatt tcttggtatt
    10861 ttttaccaca gaattggctt ttgaggttat aatagtcata gaaatattat aacacaatca
    10921 aaggggtttg gtatgcaaaa ggttagaatg attgcccaag gtagggtaca gggagtcggc
    10981 tttcgttggg gtgtttacag cttggccctt gaaatcggtg gcatcacagg tcgggtatgg
    11041 aataacgacg atggcacagt ggaaatctta gcccaagcag actcatctgc tatcatggca
    11101 aaatttatcc aagaaatccg aaaaggaccg acaccttttt caaaagtaag ctacttagat
    11161 gtcaaactaa gcaactttcc tccctactct gactttaaaa tcgcaaatta ggtctccaga
    11221 actattgtat attttgtaaa aaaacagtag aatagaaagg tataattttt aaagaaggaa
    11281 taaaaacagt gaaatctatt aaacgttttg cattctcggc tatgggagtg gctatgttgc
    11341 ttgtcttgac tggctgtgtc aatgtcgata aaaccacagg tcagccaaca ggatttattt
    11401 ggaatacgat cggagcgcct atggctgaag ccatcaagta cttcgctact gataaaggtc
    11461 taggctttgg tgtcgctatc attatcgtaa ccattatcgt acgcttgatt atcttaccac
    11521 ttggtatcta ccaatcatgg aaggcaacgc ttcactctga aaagatgaac gctctcaagc
    11581 atgtccttga gccacaccaa acacgtctca aagaagcaac tactcaagaa gaaaaactcg
    11641 aagcccaaca agccctcttt gccgctcaaa aagagcacgg catcagcatg tttggtggtg
    11701 taggatgttt ccctatcctc cttcaaatgc ctttcttctc tgctatctac tttgctgccc
    11761 aacatactga aggggttgct caagcaagct acctaggcat tcctctaggt tctccaagta
    11821 tgattttggt tgcctgtgct ggtgtccttt actatcttca atcgctcctt tcacttcacg
    11881 gggtagaaga tgaaatgcaa agagaacaaa tcaagaaaat gatttacatg agcccactca
    11941 tgatcgtcgt cttctccctc ttctcaccag ccagtgttac actttactgg gttgtcggtg
    12001 gtttcatgat gattctccaa cagtttatcg tcaactatat cgttcgtcca aaacttcgca
    12061 aaaaagtccg tgaagaacta gccaagaacc caccaaaagc aagtgctttc tctaaaccaa
    12121 gtggacgaaa agacgttacc cctgaacaac caactgctat cacaagcaag aaaaaacaca
    12181 aaaatcgcaa cgctggaaaa caacgttcga gataagaaga aaaaggctta gctgatttgc
    12241 taagtctttt tgcaaatcaa aagcccgatg tttccatcag gcttcttttc tatccatgta
    12301 cacgtttcat ataatcttga taactttcgg tatccatgag ttttttagcg ttcttgacgc
    12361 gatctgctgt tggtggtttg actccttcga gggaatatgg aattccaagt tcacgccact
    12421 tgaactcacc catggtgtga taaggtagaa tttcaaactt atcaacattt ttgagggtct
    12481 tgacgaactt accaagttca atcaagtcat catctctgtc tgtcaatcct ggaactagca
    12541 cgtggcgaat ccagacaggt tttccaatat ctgatagata ctgggcacaa gccaagatat
    12601 ttttattagt ttgtctagtg acaatcttgt gctgttcttc gttgatttcc ttgatatcca
    12661 aaagaaccaa gtcagtgaca gccatgagtt tgtcaaactt ctcaaggtaa cgtggtttat
    12721 tacggaaagg aagagcacag gtatccaagg tacagtggat tccttgttcc ttagccttgg
    12781 tgaagagagc aatcaggaaa tcaatctgca agagagcttc tcctccactg actgtaatcc
    12841 cacccttatt tccccagaaa ccacggtagc gcaaggcctc tgtcaagaca tcatctaccg
    12901 tccgttcacg tgacttattg gactccatag cccaagtgtc tgggttgtgg caatactggc
    12961 aacgcatgtg acagccctgc aaaaagacaa taaagcgaat accaggccca tctactgacc
    13021 caaagctttc tgtcgaatgc accattcctg tcacttgtcc ataatcaatt gtttcttcag
    13081 acatatcgtt accttccttg aaaacgtttt atagttttat tatatcatga cttgaaggaa
    13141 aaacaagatt tttgcctatt ttttagaaag caatctgttt ttcaatttca ttttcaatct
    13201 attatcagat tattcttcaa aatcgaagcc atataaggtt gcaaaatagt cctcagggcg
    13261 ctctgcacgg cggatttgac gggctttacc ttcttcggta tagaggattt ccgcagaacg
    13321 taatttggca ttatactggt agcccattga aaatccgtgg gcacctgtat catgaatgac
    13381 cagcaaatca ccgatttctg tatgaggcag ttcgcgattg actgcaaatt tatcattgtt
    13441 ttcacagagt gaaccaacca catctaccgc ttcagctggt ccatctggat gggtcacgtt
    13501 gctaatatga tggtaagctc cgtacatagc tggacgcatg aggttgactg ctgaggcatc
    13561 cacacctaga taggtacggt aggtttcctt cttatgagtc actcttgtga ctagagcacc
    13621 gtgaggtgcc agcataaaac gacccaattc ggtgaaaatc ttgacctgac caagacctgc
    13681 tgacgtaaga acttcttcat acaccttacg aactccctca ccaatcaagg cgatatcgtt
    13741 cggctcctgg tctggacgat aattaacacc aataccgcca gaaagattga taaagtctag
    13801 cgaaatgccc aacttttcct tgatttcaac agccagttca aagagctgac gagccaactc
    13861 tggataatag agatgggtca cggtattgga cgctaggaag gagtgaatcc caaaagtctt
    13921 ggctcctttt tccttcaaga tagcaaaggc ttcaaagagc tggtccttgg tcatgccaaa
    13981 cttagcctcc ccaggattgt ccataatgtc tgtccccagt tcaaaaacgc ctccaggatt
    14041 ataacgacaa gagatgattt ctggaatgcc tgctactctc tccagatgtt caatatcttc
    14101 aaaggcatcc aagttaatgg tcgcacccaa ttcacgtgca taggcgtatt ccttgtctgg
    14161 cgtgttgttg gaagagaaca taatctcaga acccagaaag tccagtttat ggctcatcaa
    14221 aagctctaca taactagagc agtccacacc acaaccttct tcttggagaa ttttcaaaat
    14281 agctggagtt ggagtagcct taactgcaaa atattcctta aagcccttgt tccacgaaaa
    14341 agcttggttg acggctcttg ccttctcacg aatccccttc tcatcataca agtgaaaggg
    14401 agtcgggaac tcggcaacaa tcgcttctaa ctcttctcta ttgataaatg gtgttttcat
    14461 aagcttcctt ctattctgtt tgcaaagaaa ggctgggaca atcgttccaa cctttagttc
    14521 tatctcttat ttatcttcgt caaagatatt gccaacctca acatcgatgg cttggttctt
    14581 gacatcaata ttagttacct tcaagagtga cttgtagtca aactgctttt cacgttcttc
    14641 ttgggcattg tccgcaaaga ccgctacacc tgccagttct gagtcgaact cgcgcaagag
    14701 actaatcata ccgttgaccg ttccgccacc tttcaagaag tcatccacaa tcaagacacg
    14761 gctgcctgcc ttaagactac gttttgaaag gaacattttc tcgatacggt caccacttga
    14821 acctgaaaca tagttgacgc taacagttga accttcggta attttcaggt cacggcgcac
    14881 aatgacaaaa gagacattga ggacattggc aactgcattt gcaagtggca cacccttagt
    14941 tgctacggtc ataaccgcgt caattttttg gtccataaag cttttggcaa taatacgacc
    15001 aatatttttc aagatggctg gtgtgctaag caaatcagac agatagatat aaccacctgg
    15061 caagatacgg tcactttctg acaacttggt acgcaagtct tcaaccattt ccttagcatc
    15121 ctgactcgaa atagacggtg tgaagatgac acctccgcca gccccagtca ctgtctggat
    15181 atgaccgatt tcaatttcct caaaggcgcg tttgataatg acgatatctt ctgagatgga
    15241 tgatttagca gactcatact tttcagcaaa agtattgaga ctagttagtt tataaggatt
    15301 attaatcaaa tagttggaaa tgacaaccat ccgatcactt cttcttaatt tcatttctat
    15361 ttcctattcc atttttattc aaaaaatcaa aaagcaaact agaaagctgg tcgctggtgg
    15421 ttcaaaacac tgttttgaga ttgtcgatag aactgacaaa ccctgtaata tacctgcata
    15481 tatacatacg acaaagcgat actaccctag tttgaagata ttttcgaaga gtattcattt
    15541 ttgtctttta cttattatac catattcaca taaaaaaacg aacattctta tcctaaaaaa
    15601 tgctcatttt tcttaaatta tcaatctaaa tctggtttat agaaggaacg attatccata
    15661 gcgaagattt tattggtcat ctctccttta tccaccaaag ccagagctgt tgacatcatc
    15721 atcatgcttg catccagatt gtcaatcata tggataatct ctgcctccat aatacgtgga
    15781 cggactggac ttccatattc aagcaagccg tggtgactga ggatgacatg acgaagcaaa
    15841 acgacttctt ccttggtatc atcgatgccg agttccataa ctgtcttggt aatttcgcta
    15901 tcaatgagag cgatatgtcc aagaagatta cctcgcactg tgtactctgt ctggtctgg
//
LOCUS       DBMVGT010000039        15563 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.039, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000039 DBMVGT010000000
VERSION     DBMVGT010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 15563)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15563)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15563
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.039"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..743)
                     /locus_tag="AC0DU4_001358"
     CDS             complement(<1..743)
                     /locus_tag="AC0DU4_001358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="HIN4237310.1"
                     /translation="MVEIIYFLIIIIASGLGSISGMGGGIIIKPLMDSFGYHSVSDIA
                     FYSSFSVFIMAIISTTKRFSQSKEIKWRLIFTVSFSSVLGGFLGHLIFQVLLSQLSVR
                     LVSIVQMILLFVMLLVSFVLTDFKKTYQFDKIGFYMICGLLLGLISSFLGIGGGPLNV
                     SLLMVFFSISIKEATMYSLAIIFFSQLSHLATIVVVTGLNQYHLAPVPVIFLASICGG
                     VLGTVVSKVLPENWVRYCFKGMLFFVMGMT"
     gene            complement(758..1606)
                     /locus_tag="AC0DU4_001359"
     CDS             complement(758..1606)
                     /locus_tag="AC0DU4_001359"
                     /EC_number="1.8.3.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016670 - oxidoreductase activity, acting
                     on a sulfur group of donors, oxygen as acceptor [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="formylglycine-generating enzyme family protein"
                     /protein_id="HIN4237311.1"
                     /translation="MKMKKIKGGTFMMGTNSEEGFLDDFEGPQVAVSVKDFSIADTPV
                     TNQEFAQFVKETGYKTLAERQEWSFVFILFVPEAEREGYPHPAGAPWWLQVPNACWKH
                     PYGENSNLVGLEDHPVVHVALEDALAFCNWSGMSLPTEAQWEYAARGGRQSEYPWGDT
                     LLEGGYYHANTWQGRFPYENTALDGFIGTAPVYEFLPNDFGLYQMIGNVWEWCRNPRY
                     TLLASFNEDDYELPKYGIQDEEYAIRGGSFLCHCSYCNRYRVAARNGCISTSTSSHLG
                     FRCLKE"
     gene            complement(1603..3078)
                     /locus_tag="AC0DU4_001360"
     CDS             complement(1603..3078)
                     /locus_tag="AC0DU4_001360"
                     /EC_number="3.1.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008484 - sulfuric ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="arylsulfatase"
                     /protein_id="HIN4237312.1"
                     /translation="MVQTKQPNIILIVVDQMRADALSLNSKDKLVSTPTLDMMASVGY
                     NFENAYSPVPSCVPARAALLTGLDQDKSGRVGYQDEVPWNFTNTLPKVFKDMGYQTEC
                     IGKMHVFPSRQRLGFDHVLLHDGYLHVDRKYDKAYGSQFDYASDYLAFLKGKVGYDVD
                     LIDDGMDCNSWEARPWDKDEKLHPTNWVVSESISFLQRRDPTVPFFLKMSFEKPHAPL
                     NPPKYYFDMYMERLPQFLDLHIGNWEVLEKQIPSIYALRGKLKEDDQRRMVAAYFGLI
                     THIDHQISRFLTALKEFRHDKDTIIWFVSDHGDQLGEHYLFRKGYPYQGSIHIPSFIY
                     DPAGLIAGNRGTIKQLVKIQDIFPSLVDLAGGTTTDELDGRSVKNLLFGQYEGWRTEF
                     HGEHALGKDSSQYILTDQWKFIWFPVLNHYQLFDMKKDPHEMNDLYPSEKYQPIVRQM
                     KKKLVDFLRYREEGFVVDEELVPVELSKITPTLTKTGDSQS"
     gene            complement(3401..4756)
                     /locus_tag="AC0DU4_001361"
     CDS             complement(3401..4756)
                     /locus_tag="AC0DU4_001361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HIN4237313.1"
                     /translation="MNTMLDKMQEKLSPIAMKVGNQKFLVALRDSFVGTMPVIMTGSI
                     ALLLNAFLVDLPQQFHLESITKTFQWLVDINNLVFKGSIPIVSLLFIYCLGVNIAKIY
                     KVDTVSAGLVSLASFVISIGSTVTKSFPLANVGDVKLDQILQGIDNLAFDGKNLMVTI
                     GNVIPGNHINARGYFTAMMIGFLASIIFCKVMKKNWVIKLPDSVPPAIAKPFTSIIPG
                     FMAMYIVAILTYVFHLLSNDLLIDWVYKVLQTPLLGLSQSFFAVILMIFLNKLFWFFG
                     LHGGNVLAPIMEGLFGVAMLANLDAFQKGEPIPYIWTSGSFGAFVWFGGLGLVLAILI
                     FSRNSHYRKVAKLGLAPVLFNIGEPVNYGLPVVLNPLLFIPFVLSPVFMATVAYWATS
                     WGLVSPVTQNVTWVMPPILYGFFSTAFDWRAIILSVVCLIISVLTYFPFVKMAYKTEL
                     S"
     gene            complement(4766..5083)
                     /locus_tag="AC0DU4_001362"
     CDS             complement(4766..5083)
                     /locus_tag="AC0DU4_001362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HIN4237314.1"
                     /translation="MDESNLESVMGLIMYGGEAKSNAMEAIQAAKKGDFSKANRGLAD
                     ANAALLQAHKAQTEMLTREAQGEKTSISLLMVHAQDHLMTSLTFVDLAKEVVEVYERF
                     EKN"
     gene            complement(5100..5417)
                     /locus_tag="AC0DU4_001363"
     CDS             complement(5100..5417)
                     /locus_tag="AC0DU4_001363"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001151647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4237315.1"
                     /translation="MAKVTIMLACAAGMSTSLLVTKMQKAAEDKGLDAEIFAVPAPEA
                     EEIVATKEVNVLLLGPQVRYLLGDFQEKLKDRQIPVAVIPMTDYGMMNGSKVLDLAES
                     LLD"
     gene            complement(5432..6328)
                     /locus_tag="AC0DU4_001364"
     CDS             complement(5432..6328)
                     /locus_tag="AC0DU4_001364"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="haloacid dehalogenase-like hydrolase"
                     /protein_id="HIN4237316.1"
                     /translation="MKRLISANPSEILQMNAEELKQSILASEGRVVLSENVVTRETFV
                     GDITNSEIARAFGADMILLNCVDVFEPKIYALDSSGDDVIHRLHQLVACPIGVNLEPI
                     DPSAKMLEETQEIVAGRVASVETLNRIEELGFDFVCLTGNPGTGVSNQEIIKAVQSAK
                     ENFSGLIIAGKMHGAGVNEPVAELSVAEQLLEAGADVILVPAVGTVPAFHDQELREVV
                     DLVHSKGGLVLSAIGTSQETSDTDTIKEIALRNKICGVDIQHIGDAGYGGLATVDNIY
                     ALSKAIRGVRHTVSRLARSVNR"
     gene            complement(6331..7593)
                     /locus_tag="AC0DU4_001365"
     CDS             complement(6331..7593)
                     /locus_tag="AC0DU4_001365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413340.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HIN4237317.1"
                     /translation="MEKLLQEKLLPVAARLGNNKALVSIRDGITLTIPLLLIGSLLMV
                     IASFPIPGWEKYLGDIGVADYLWKGVDSSFGLLGLVASFGIAYFMARQYKVDGIPAGI
                     VSLSSFITVTPFITGEAGAGMPTAFMASKGLFVAMILGLINGYIYQWFINHNIQIKMP
                     DGVPPAVSKSFSAIIPGAVTIVGWLIVYATLDKLSLPNLHEIAQVALGGPLGLLGNNV
                     IGLLILIFLNSSFWFVGLHGGNVVNAVMKPLWLANLDANKVAYQTGETLPNIFTSVFM
                     DNFVFIGGGGATIGLVLALGYLAHKKKASKQLKTLAPITVIPGLFNINEPAMFGVPIV
                     LNILLLVPFILAPMFNLLVAWGAMASGLVPLTYTDPGWTMPPVISGLLATGSISGSLL
                     QIVLIVLDVLLYLPFVIAIEKRFKLLED"
     gene            7873..9051
                     /locus_tag="AC0DU4_001366"
     CDS             7873..9051
                     /locus_tag="AC0DU4_001366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HIN4237318.1"
                     /translation="MTLSKKQLQLRAKILETVYTLGPISRIEIATKTGITPATTSSIT
                     NDLIKENILLELGEDEHDTSVGRKKILLDIQAKRFYYIGCELSEKHFTFALGDNLGNI
                     LKEEKEIVTKQLIQEKGNQLINQTLKQFLNNCSDYEIEAIGIALPGRYLDNYKITTNN
                     PLWQHIDLEMIQSHFDKPLFFSNNVNCMAIGKRLFSRQQNDPNFAYFHFARGMHCSYI
                     YDGNIYGKGNLMIGEIGHTVVSSEGEECSCGRKGCLQTFAGESWLIKKSKILYHQSPY
                     SLLPSLVKNADDIDIQVILTAYQLGDTGIITLIHQALLYLSQTILNISMMIDSQKIYL
                     HSPLLTNQHIIQKLYSEMNYKPKLLYNRLPEVIIEPYNDFTAAHSAIALCLYHTILHS
                     "
     gene            complement(9279..9725)
                     /locus_tag="AC0DU4_001367"
     CDS             complement(9279..9725)
                     /locus_tag="AC0DU4_001367"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000155432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4237319.1"
                     /translation="MTIRFEEKVSIENAQFVCQWSNSLGKSFQEQWMGPRIPFLLTLQ
                     ALEGVFSIFDEQEFVGLIQKIRLEDSNLHIGRFFINPQKQEQDLGSQALRKFVSLAFE
                     NEDIDSISLNVFEANQRAQNLYQKEGFEIVQMVEAPVRKYSRLKLE"
     gene            9795..10454
                     /locus_tag="AC0DU4_001368"
     CDS             9795..10454
                     /locus_tag="AC0DU4_001368"
                     /EC_number="3.4.23.43"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000564993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HIN4237320.1"
                     /translation="MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLR
                     PLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLGLLFLLYSWELLSLGQVVLITAG
                     LTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
                     FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLL
                     V"
     gene            complement(10506..11657)
                     /locus_tag="AC0DU4_001369"
     CDS             complement(10506..11657)
                     /locus_tag="AC0DU4_001369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237321.1"
                     /translation="MFNGRVLKELRLLNGLSRAELAQRINLTEQAIWQFESNETKPKL
                     STKMHLANQFHVDLTYFEQEEESIRFDSSVIAFRNADLATRKTIDIQTMYLHKVDSLI
                     DYFESFVIIPNIIIHDLSNVVSESYHKGESIEELALYAREKLGISKDNHDLLYKLERS
                     GIYIVERLINGQADAYSAWSKLGRPYIVLGTNKSSVRRNFDLAHELGHILLHKYKDMN
                     EDGDRLEQEANYFASCFLLPKEEFLVKFEERVGKRASNPDSYILLKSDLNVSIQALEY
                     RAFKLGLLTPKQHSYFYRQIAQKGYKMIEPLDDQIFVKKPSKVKSILDVVLSNHLVSL
                     ATIMSKQSICLQFISEIFSVEMKFFDQYQEDRRTDRFDNIIPLYKRNNL"
     gene            complement(11672..12403)
                     /locus_tag="AC0DU4_001370"
     CDS             complement(11672..12403)
                     /locus_tag="AC0DU4_001370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000934015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237322.1"
                     /translation="MLNQDLFDSLEAQKIVDTLMKGQKDYVDERLEKRETMIVSNGYA
                     WTRPNHIDTAFASADLFEYKLQLAGQTWGYLEFETNTEKYGKVLLIIKGKKRLTNQFP
                     LVQKNKSGYLFEYAQMNTLYLNQHSSYKNDEDSHSFPIQMELVSDEMIQEIEQATKNS
                     NIEKFMILTYEADSENNIISVDVVMPDARTGQLHLIQDLSEYIQSSSYHFEEAKYQDI
                     PNFSELSETEDFEIIPRIEKQEGQK"
     gene            12629..12733
                     /locus_tag="AC0DU4_001371"
                     /pseudo
     CDS             12629..12733
                     /locus_tag="AC0DU4_001371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234126.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
     gene            complement(12705..13481)
                     /gene="trpA"
                     /locus_tag="AC0DU4_001372"
     CDS             complement(12705..13481)
                     /gene="trpA"
                     /locus_tag="AC0DU4_001372"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004834 - tryptophan synthase activity
                     [Evidence IEA];
                     GO_process: GO:0000162 - L-tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="HIN4237323.1"
                     /translation="MPKTLTEKLNAIKVTGKGIFVPYIMAGDHEKGLDGLAETIHFLE
                     DLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTY
                     FNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGI
                     ERQKELIAGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQA
                     DLERFNAVSDGVIVGSKIVKALHQGEPIQDFIRQAVAYQK"
     gene            complement(13474..14697)
                     /gene="trpB"
                     /locus_tag="AC0DU4_001373"
     CDS             complement(13474..14697)
                     /gene="trpB"
                     /locus_tag="AC0DU4_001373"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004834 - tryptophan synthase activity
                     [Evidence IEA];
                     GO_process: GO:0000162 - L-tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit beta"
                     /protein_id="HIN4237324.1"
                     /translation="MAYQEPNKDGFYGKFGGRFVPETLMTAVLELEKAYRESQADPSF
                     QEELNQLLRQYVGRETPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQVWLA
                     KRMGKKKIIAETGAGQHGVATATAAALFNMECTIYMGEEDVKRQALNVFRMELLGAKV
                     EAVTDGSRVLKDAVNAALRSWVANIDDTHYILGSALGPHPFPEIVRDFQSVIGREAKQ
                     QYRDLTGQNLPDALVACVGGGSNAIGLFHPFVEDESVAMYGAEAAGLGVDTEHHAATL
                     TKGRPGVLHGSLMDVLQDAHGQILEAFSISAGLDYPGIGPEHSHYHDIKRASYVPVTD
                     EEALEGFQLLSRVEGIIPALESSHAIAFAVKLAKELGPEKSMIVCLSGRGDKDVVQVK
                     DRLEADAAKKGEAHA"
     gene            complement(14675..15274)
                     /locus_tag="AC0DU4_001374"
     CDS             complement(14675..15274)
                     /locus_tag="AC0DU4_001374"
                     /EC_number="5.3.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylanthranilate isomerase"
                     /protein_id="HIN4237325.1"
                     /translation="MTKVKICGLSTKEAVETAVSAGADYIGFVFAPSKRQVTLEEAAE
                     LAKLIPADVKKVGVFVSPSRVELLEAIDKVSLDLVQVHGQVADDLFENLPCASIQAVQ
                     VDGNGHVPNSQADYLLFDAPVAGSGQSFDWGQLDTTGLAQPFFIAGGLNEDNVVKAIQ
                     HFTPYAVDVSSGVETDGQKDHEKIRRFIERVKHGISGTK"
     gene            complement(15261..>15563)
                     /locus_tag="AC0DU4_001375"
     CDS             complement(15261..>15563)
                     /locus_tag="AC0DU4_001375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011227478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indole-3-glycerol phosphate synthase TrpC"
                     /protein_id="HIN4237326.1"
                     /translation="LEVLVETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDL
                     APYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQAENVVQRIKELQIDKG"
BASE COUNT         4946 a         3400 c         2413 g         4804 t
ORIGIN      
        1 gtcattccca tgacaaagaa taacatccct ttaaaacagt atcttaccca attttcaggt
       61 aagacttttg atacaaccgt ccccaatacc cctccgcata tagaagcaag aaaaataact
      121 ggaacaggtg ctaaatgata ctgatttaaa cctgtaacca caacaattgt agccaaatga
      181 gacaactggg aaaagaaaat aattgcaaga gaatacatcg ttgcttcttt tatcgaaata
      241 gaaaaaaaca ccatcaataa agatacattg agcggaccac caccaatccc taaaaaacta
      301 gaaatcaagc ccaatagaag accacaaatc atatagaatc ctatcttatc aaattgataa
      361 gtttttttaa aatctgttaa aacaaatgat acaagtagca tcacaaatag taaaatcatt
      421 tgaacaatgg atactagccg tactgataat tgagataaca aaacttgaaa aataagatga
      481 cctagaaacc ctcctaaaac agaagaaaag gataccgtaa aaatcaatct ccattttatc
      541 tctttacttt gtgaaaatct tttggttgtt gaaataatcg ccattataaa aacagagaaa
      601 ctagaataaa aagcaatatc actgaccgaa tggtatccaa aactatccat aagtggctta
      661 attataattc caccacccat gcctgatata gaacccaatc cactagctat tataatgatt
      721 agaaaataaa taatctcaac cactttttaa gtccatccta ttctttcaaa catctaaaac
      781 ctagatggct actagtggaa gtagaaatac atccatttct agcagctact cggtatcgat
      841 tacaataaga acaatgacat aaaaaggaac ctcctctgat agcatactcc tcatcttgta
      901 tcccatattt tggcaactca tagtcatctt cattaaaact agctaataag gtatatctcg
      961 gattgcgaca ccattcccaa acattcccaa tcatttgata tagaccaaaa tcattaggta
     1021 aaaattcata gacaggagcc gttcctataa atccatctaa ggcagtattt tcataaggaa
     1081 atcttccttg ccaagtattg gcatgataat atccaccttc taaaagagta tctccccaag
     1141 gatattcaga ttgtcttcct cctctagcag catattccca ctgtgcttca gtcggtaaag
     1201 acattccgct ccaattacag aaagccaatg catcttctaa agcaacatga actactggat
     1261 ggtcttctaa acccactaga ttactattct caccgtaggg atgtttccag caagcgttcg
     1321 gaacttgtaa ccaccacgga gccccagcag gatgaggata tccctccctt tctgcctctg
     1381 gaacgaacaa tataaaaaca aaagaccact cttgtcgctc agctagtgtt ttatagcctg
     1441 tttctttcac aaattgagca aattcttgat tcgtaactgg agtatccgca atggaaaaat
     1501 cctttacact aacagcgact tgaggacctt caaaatcatc taaaaagccc tcttcagaat
     1561 ttgttcccat cataaatgtc ccacccttga tttttttcat tttcatgatt gactatcccc
     1621 cgttttcgtt agagttggcg ttattttaga aagttcaaca ggaactaact cttcatccac
     1681 aacaaaacct tcttctctat atctaagaaa gtctactaat tttttcttca tctgacgaac
     1741 aataggttgg tatttttcac ttggatacaa atcattcatt tcatgcggat cttttttcat
     1801 atcaaataac tgataatgat ttaaaacagg aaaccagata aatttccact ggtctgtcaa
     1861 gatatattga ctagaatctt ttcctaaagc atgttcacca tgaaattctg ttcgccaccc
     1921 ctcgtactgt ccaaataata aattcttaac actccgtcca tctagttcat ctgtagtagt
     1981 tcctcctgcc aaatccacga gtgaaggaaa aatatcttga attttcacta attgcttgat
     2041 tgttccccta ttaccagcta tcaatccagc cggatcgtaa ataaacgaag gaatgtggat
     2101 acttccctga taaggatatc cctttctaaa cagataatgt tcaccaagct gatctccatg
     2161 atccgaaaca aaccagataa tcgtatcttt atcatgacga aattctttta gggcagtcaa
     2221 aaagcgacta atttgatggt ctatatgagt aatcaatcca aaataagcag caaccattct
     2281 tctttgatca tcttccttta atttccctct taaagcataa atagacggaa tttgcttttc
     2341 taatacttcc caattcccga tatgcaaatc gagaaattga ggcaagcgtt ccatatacat
     2401 atcaaaatag tattttgggg gatttaatgg agcatgtggt ttttcaaaag acattttgag
     2461 aaaaaaagga accgttggat ctcttctttg taaaaatgaa atggactcac tcacaaccca
     2521 gtttgttgga tgtaacttct catctttatc ccaaggtcta gcttcccaag aattacaatc
     2581 cattccgtca tcaatcaaat caacatcata accaacttta ccctttaaaa aggctagata
     2641 gtcactagca taatcaaatt gacttccata agccttatca tactttctat caacatgtag
     2701 atacccatcg tgaagtaaga catgatcaaa cccaagtctc tgtctggaag gaaaaacatg
     2761 catcttacca atacactctg tttgataacc catatcttta aagacttttg gaagagtatt
     2821 agtaaaattc caaggcacct catcttgata accaactcgt ccacttttat cttggtctaa
     2881 gccagtcaat aaagctgccc tagcaggaac gcaagaagga actggagaat aggcattttc
     2941 aaaattataa cctacactag ccatcatatc taatgttgga gtgctaacta gcttatcctt
     3001 actattcaag gataaggcgt ctgctctcat ttgatctaca acaatcaaaa taatatttgg
     3061 ctgttttgtc tgaaccataa aatctccttt ctaatatggc aaaagaggca caagaagata
     3121 tctaccttta ctgcacccct ttctatatca atctctctat ataaaacaat aacattcttg
     3181 ttatgtttta tagaaaaatg aactaaaata tgactaaatc gattaggaaa ttcaaatcat
     3241 tttctagtac tgttttagaa gttacagtgt actattccaa cttcaataaa ctataaacct
     3301 ttgtctaata acaattttag tggagataag aaatcctaca cctaactcat cttacacgta
     3361 atctatttct attttatcac aaaaaacgca agtaagacca ttaactcaat tcagttttat
     3421 atgccatttt cacaaatggg aaataagtca agacactaat aatcaaacaa acaactgata
     3481 agatgatggc acgccaatca aatgctgtag agaagaaacc atataaaatt ggaggcatta
     3541 cccaagtaac gttttgtgta acaggtgaaa caagacccca gcttgttgcc cagtaagcta
     3601 ccgttgccat gaaaaccgga ctaagtacaa atggtataaa tagcaaagga ttcaagacaa
     3661 ctggtaaacc ataattgacc ggctcaccaa tattaaacag aactggtgct agaccaagtt
     3721 tagcaacttt tcgataatga ctgtttcttg aaaaaattaa aatagcaagt actaatccta
     3781 atcctccaaa ccagacaaac gccccaaaag acccacttgt ccatatataa ggaatcggtt
     3841 cacctttttg gaaagcatcc agattcgcta acatagcaac tccaaacagc ccttccatga
     3901 tgggagccaa tacatttcct ccatggagac caaaaaacca gaataactta ttcaaaaaga
     3961 tcatcagaat aactgcaaag aaactttgag acaaacctag taatggcgtt tgtaacacct
     4021 tgtaaaccca atcaatcaat aagtcattgc taagtaaatg gaaaacataa gtcaagatgg
     4081 ctactatata catcgccata aatcctggaa tgatagaagt gaacggctta gcaatcgcag
     4141 ggggaactga atctggtaac ttgattaccc agttcttttt cattacttta cagaaaataa
     4201 tagaggctaa aaatccaatc atcatggctg taaagtagcc tctggcatta atatggtttc
     4261 ctggaatcac attcccaata gttaccatca gatttttacc atcaaatgct agattatcaa
     4321 ttccttgtaa gatttgatct aatttcacat ctcctacatt tgccaaaggg aaactctttg
     4381 taactgtact tccaatcgaa atgacaaacg aagcaagtga taccaaacca gcagaaactg
     4441 tatcaacctt gtaaatctta gcgatattca ctcccaagca atagatgaac aacaaggaaa
     4501 caattggtat acttcccttg aataccaaat tattgatgtc aacaagccac tgaaaggttt
     4561 tcgtaatact ttctaggtga aattgttgtg gtaaatccac tagaaaagca tttaataaca
     4621 aagcaatgga acctgtcata ataacaggca tagtccccac aaatgaatca cgtaaagcaa
     4681 ctaaaaactt ctgattccca actttcattg caattggaga aagtttttct tgcattttat
     4741 ccaacattgt attcatacca aactcctaat ttttttcaaa tcgttcgtat acttctacca
     4801 cttctttcgc caagtcaaca aaagtcagac tcgtcattaa atgatcttgc gcgtgtacca
     4861 tcaagaggct aattgatgtt ttttccccct gtgcctctct tgtcaacatt tctgtttgag
     4921 ccttatgcgc ctgtaataag gcagcattcg catcagctaa tcctcgattg gctttagaga
     4981 aatccccttt ttttgctgcc tgaatagcct ccatagcatt acttttggct tccccaccat
     5041 acataattag ccccattaca gattctaaat tactttcatc cataacattc tcctcaatct
     5101 tagtctaata aactttcagc taaatctaaa actttagaac cattcatcat tccgtaatct
     5161 gtcatcggaa taaccgccac aggaatctgt ctatctttta gtttttcttg aaagtcccct
     5221 agtaaatagc gaacttgagg acctaaaagc aacacattta cttcttttgt tgctacaatt
     5281 tcttctgctt caggagctgg aactgcaaaa atttctgcat ccaacccctt atcttctgct
     5341 gccttttgca tctttgtcac tagcagactt gtactcatac ctgctgcaca tgctaacata
     5401 attgttactt tagccatagc ttactccttt atcacctatt tactgaccta gccaagcgag
     5461 atactgtatg tctcactcct ctaattgcct tgctcaatgc ataaatatta tcgactgttg
     5521 ccagtccccc atatcctgcg tcacctatat gttgaatatc aactccacaa attttatttc
     5581 taagtgcaat ttccttgata gtatctgtat cagatgtttc ttggctagta ccaatagcac
     5641 tcaatacaag accaccctta ctatgaacga gatcaacgac ttcacgcaac tcttggtcat
     5701 gaaaggctgg aacggttcca actgctggaa caagtatcac atccgcacct gcttccaaca
     5761 attgctctgc gacagaaagc tctgccacag gctcattcac tcctgccccg tgcattttac
     5821 cagctataat caaacctgag aaattctctt tagcagattg aactgctttg ataatctctt
     5881 gattgctaac tcctgttcca ggatttccag tcaaacagac aaagtcaaaa cctaactcct
     5941 ctattcgatt caatgtttca acactagcaa cacgacctgc aacaatttcc tgtgtttcct
     6001 ctagcatctt tgcagatggg tcaatcggtt ccaaatttac accaattgga caagcaacaa
     6061 gctggtgtaa gcgatgaata acatcatcac ctgaactatc caaagcataa attttaggct
     6121 caaaaacatc aacacaattc aataaaatca tatcagctcc aaaagctcta gcaatttcag
     6181 aattagttat atccccaaca aatgtctcac gagtaactac attttcagat agaacaactc
     6241 taccttcact tgctaaaata ctttgtttta attcttcagc attcatctgt aatatctcag
     6301 atggatttgc actaattaaa cgtttcattc tcaatcctcc aataacttaa accgtttttc
     6361 aatagctatt acaaatggta aataaagtaa gacatccaaa acaatcaata caatttgtaa
     6421 taatgaacca gaaatacttc ctgtagcaag taaaccactt ataacaggtg gcatagtcca
     6481 acctggatct gtataagtta gcggaaccaa acctgatgcc attgctcccc acgctactag
     6541 taagttaaac attggagcta agataaatgg aactagtaac aaaatgttca aaacaatagg
     6601 aacgccaaac attgctggtt catttatatt aaataatcca ggtataacag ttataggtgc
     6661 caaagttttt agttgtttac tagctttctt cttatgtgct aaatatccta acgcaagaac
     6721 taaacctatg gttgcaccac cgccacctat gaatacaaaa ttatccataa atacgctagt
     6781 aaaaatattt ggaagagttt ctccagtttg ataagctact ttatttgcat ctagattagc
     6841 taaccataac ggtttcataa ctgcattaac aacatttcct ccgtgtaatc ctacaaacca
     6901 aaaactacta ttaaggaaaa ttaagataag aagaccaata acattatttc ctaaaagtcc
     6961 aagtggacct cccaaagcta cttgagcaat ttcatgaaga ttaggtaaac ttaatttatc
     7021 taaagttgca taaacaatca accaaccaac aatagtcact gcaccaggaa taatggcact
     7081 aaagctttta gatactgctg gtggaacacc atccggcatt tttatctgta tattatgatt
     7141 tataaaccat tggtagatat agccattaat caatcctaaa atcatagcaa caaataaacc
     7201 ttttgatgcc atgaaagcgg taggcattcc tgctccagcc tctcctgtaa tgaaaggcgt
     7261 aactgtaata aaagatgata atgacacaat accagcagga ataccatcaa ctttgtattg
     7321 tctagccata aagtaagcga taccaaaact agctacaaga ccaagtaatc caaaactact
     7381 atcaacaccc ttccataaat agtcagcaac accaatatca cccagatatt tttcccatcc
     7441 tggaatagga aaacttgcaa taaccattag taatgaacct atcaacaata aaggtatagt
     7501 tagagtaata ccgtctcgaa tagaaaccaa cgctttatta ttacccaatc tagccgctac
     7561 tggaagtaac ttttcttgta ataatttttc cataaccttt tcctcttaaa tatattttat
     7621 tatcaaaagt tatcaattat ctttattttt tgacgtcaag ttgttatttg attatctttt
     7681 gttatttata ttttacaact ataagaaagc cttgtcaagg atttgtgtaa atatttgatt
     7741 attttttatt atcaatatat aataaaaaga gaccagtaag caatgaaaag cttaaaaaga
     7801 ttaacatcta catttatcca tagcaaaaaa tcataggatt ttaagaatct gacaactagg
     7861 aagaaaacta atatgacctt atctaagaaa caattacaac taagagctaa aatactggaa
     7921 acagtttaca cattaggtcc catttcacga attgaaatcg ctactaaaac aggaataaca
     7981 cctgcaacaa ctagcagtat cacaaatgat ctgattaaag aaaatattct cttagaactt
     8041 ggtgaagacg aacacgatac aagcgtaggg agaaaaaaaa tcctgctaga cattcaagct
     8101 aaacgatttt actacattgg ttgtgaacta tctgaaaaac atttcacttt tgctttagga
     8161 gataatctag gaaatatctt aaaggaagag aaagaaattg ttactaaaca gttaatccaa
     8221 gaaaagggaa atcaactcat taaccagaca ctaaagcaat tcttaaataa ctgctctgat
     8281 tatgaaatag aagcaattgg aatcgcgcta cctggtcgct atttagataa ttataaaata
     8341 acaacaaaca atcctttatg gcaacatatc gacttagaaa tgattcaatc ccactttgat
     8401 aagcctttgt ttttctctaa caatgttaac tgtatggcta taggtaaacg cctatttagt
     8461 cgccaacaga atgaccctaa ttttgcttat tttcattttg ctagaggtat gcactgttct
     8521 tatatctacg acggaaacat ttatgggaaa ggaaatctaa tgattggaga aatagggcat
     8581 acagttgttt catctgaggg agaagaatgt agctgcgggc gcaagggatg cttacaaact
     8641 tttgctggag aatcttggtt aatcaaaaaa tcaaaaattc tatatcatca atctccctat
     8701 tctctacttc ctagtttagt caaaaatgcc gatgatattg atatccaagt tattttaacc
     8761 gcttatcaat taggtgacac tggaataatc acacttatcc atcaagcctt actctatctt
     8821 agtcaaacca ttttaaatat cagtatgatg attgactctc aaaaaatcta cctacatagt
     8881 cctttactaa caaatcaaca catcatccaa aaactatata gtgaaatgaa ctacaaaccc
     8941 aaactgctct ataatcgcct acctgaagtc attattgaac cttacaatga ttttacagcc
     9001 gcacactcag ctattgcact ttgtttgtat catacaattc tacattctta attttctatt
     9061 acatttaata aataggctaa aaagagggag tatatcataa aaagcgaata aacctgtttt
     9121 ctgaaaatca gaattctgtt ttgttcgctt tctttatatt tggaattata ctcctatctc
     9181 ccctttttca taatgtataa taaaatgaaa taataacagg acgaatcgct cgggacagtc
     9241 aaatcgattt ctaacaatgt tttagaagta gaggtgtact attctagttt caatctacta
     9301 tattttcgta caggtgcttc aaccatttga acgatttcaa atccttcttt ttggtaaaga
     9361 ttctgagctc tttgatttgc ctcgaagaca tttagagaaa tactatctat atcttcattt
     9421 tcaaaggcca aactaacaaa tttccttaaa gcctggctac ctaagtcttg ctcctgtttc
     9481 tgggggttga taaaaaatct cccgatatga agattgctgt cttctagcct gattttctgg
     9541 ataagtccca caaactcttg ttcatcaaag attgaaaaga ctccttccaa ggcttgaagg
     9601 gtcagtagaa aaggaatcct tggtcccatc cattgttctt gaaaggattt gcctagggag
     9661 ttggaccact ggcatacaaa ttgagcgttt tctatactca ccttttcttc aaaacgaatt
     9721 gtcatctttt cctcaccatc ttatctatgt ttctccatta tactatttct cccatttttt
     9781 acgaatagat aagtatgatt gatttttatt tttttctcgt cgggagcatt ctcgcttcct
     9841 ttcttggttt ggtcattgac cgttttccag agcaatccat tatcagttca gccagtcact
     9901 gcgattcctg tcagactcgc ttgcgtccct tagatttgat tccgattctc tcacaggtct
     9961 tcaatcgctt tcgctgtcgc tactgcaaag ttcgctatcc tgtctggtat gccctctttg
    10021 aattagtctt aggactcctc tttctgcttt actcttggga attgctttcc ttggggcaag
    10081 tcgtcctaat caccgctggt ttgaccttgg gtatctacga ctttcaccat caggaatatc
    10141 ccttactggt ctggatgact ttccacctaa tcctaatagc ttcctctggc tggaatctgg
    10201 tcatggtctc cttccttgct cttggaattt tggctcattt tatcgatatc cgcatgggcg
    10261 caggagattt cctcttttta gcttcttgtg ctctcgtctt tagcgtaacg gagttactga
    10321 tcttgattca gtttgcttct gcgacgggta tcctggcctt tatcctgcaa aagaaaaagg
    10381 aaagacttcc tttcgtgcct ttcctcttac ttgctacttg tttgattatt tttggtaagc
    10441 tactgcttgt ctgataaaat ccaatttctg ccatatgtcc ttcatgaaat tatttcacag
    10501 ttaaattata aattatttct tttgtacaaa gggatgatgt tatcaaatcg atctgttctt
    10561 ctatcttctt gatactgatc aaaaaatttc atttcgactg aaaatatttc gcttataaac
    10621 tgtaaacaaa tactttgttt agacattata gtcgctagac tgactagatg attactcaaa
    10681 acgacgtcca gaatactctt tactttgctt ggttttttaa caaaaatttg atcatccaaa
    10741 ggttcaatca ttttgtaacc tttttgcgca atttgacgat aaaagtaaga atgttgcttt
    10801 ggagtcaata atcctaactt aaaagctcga tactctaaag cctgtatcga aacattcaaa
    10861 tccgacttca ataaaatata actatcagga ttgctggcac gcttgccaac cctctcttca
    10921 aatttgacta aaaactcttc ttttggcaat aaaaaacatg atgcaaaata atttgcttct
    10981 tgctccaaac gatcgccatc ttcattcata tccttatatt tatgtaaaag aatatgtcct
    11041 agctcatgag ctaagtcaaa atttcgacgt acagatgatt tattcgttcc caacacaata
    11101 taaggtcttc ccaattttga ccatgcgcta taagcatcag cttggccatt aattaatcgt
    11161 tccacgatat agatacctga acgttctaat ttataaagca aatcatgatt atcttttgaa
    11221 atacctaatt tttccctggc ataaagagcc aattcctcaa tggattctcc cttatgataa
    11281 gattcactca ctacattact taggtcatga attataatat taggtataat tacaaaactt
    11341 tcaaaataat caatcaaact atctacctta tgtaaataca tagtttgaat atctattgtt
    11401 ttccgtgttg ctaggtctgc atttctaaag gcaattacag aagaatcaaa tcgaatgctc
    11461 tcttcttcct gttcaaaata agttaaatca acatgaaatt ggttggccaa atgcattttg
    11521 gttgataatt taggtttcgt ttcgttggac tcaaactgcc aaatggcttg ttccgttaaa
    11581 ttaattctct gagctaattc tgctctactt aaaccattta acagccgtaa ttctttcaat
    11641 acccgaccat taaacattta tatactcctt actacttttg accttcttgt ttttctattc
    11701 ttggaataat ttcaaaatct tctgtttccg ataattctga aaaattagga atatcttgat
    11761 atttagcttc ttcgaaatgg tacgaacttg attgaatata ctcagacaaa tcttgaatca
    11821 agtgtagctg accagttcgt gcatcaggca taacaacatc tacagatata atattgtttt
    11881 ctgagtccgc ctcataagtt aaaatcataa atttttcgat attcgaattt ttagtagctt
    11941 gttcaatttc ttgaatcatt tcatcagaaa ctaactccat ctgaattgga aaggaatgac
    12001 tatcttcatc atttttgtag gaagaatgtt gattaagata aagtgtattc atctgagcgt
    12061 attcaaataa gtagccactc ttattttttt gtaccaaagg aaattggttc gtaagtcgct
    12121 tcttaccctt tataattaac aatactttcc catatttttc tgtatttgtt tcaaattcta
    12181 aatatcccca agtctgtcct gctaattgta atttatactc aaacaaatct gctgatgcaa
    12241 atgcagtatc aatatgatta ggtcgcgtcc atgcataacc attcgacact atcattgtct
    12301 ctcttttttc tagacgttca tctacataat ctttttgccc tttcatcaaa gtatctacaa
    12361 ttttttgtgc ctcaagcgaa tcaaagagat cctgattcaa cataattctt cctcctccaa
    12421 atacttttta atgaattata tcattttctt aaagaaatta ctacaataat tatctttttc
    12481 ttaaagttct gtgtcagagt aatttagaaa attatatctt ctatagtaaa atcaattaaa
    12541 aactgaacaa atttattggg aaattcaaat cgctttctga aaatatttta ggaaccgtag
    12601 tgtaatattc cagattcaat tcactataaa actgaccttt ctcctgcaaa agaaaaagga
    12661 aagacttcct ttcgtgcctt tcctcttact tgctacttgt ttgattattt ttggtaagct
    12721 actgcttgtc tgataaaatc ctgaatcggc tctccttggt ggagagcttt tactattttt
    12781 gaaccgacga taacaccatc tgacaccgca ttgaagcgtt ccagatcggc ttgactagat
    12841 acaccaaaac ctgtcaagac tgggatgtcg gccacttgat gaagttgcgc caagtgcttg
    12901 tccaaatctg cacggtaatt gcctgatttc cctgtcaccc cattgatggc aacggcatag
    12961 acgaatccct ccgcccctgc aatcaactct ttctggcgct caattcctgt ggtcaagctt
    13021 actaaaggaa tcaaggcgat atctgtatct gccaaaaatg gttctacaaa gttggcatgt
    13081 tcatgaggca agtctgggat aatcaagccc ttcacagctg tatcagccag atctttgaca
    13141 aagttctcca caccgtactg aaagaggggg ttgaagtagg tcatgatgac cagtggaatc
    13201 tctgtttcaa tggttttcaa ggtttcaact aaagcctggg tagaggtccc gtgggctaaa
    13261 ctgcgcaagc cagcttcttc gataacaggt ccatctgcaa cagggtctga aaagggaata
    13321 cccacttcaa tagcagagac acccaaatct tctaaaaagt gaattgtttc agcaagaccg
    13381 tccaaacctt tctcgtggtc accagccatg atatagggaa cgaaaattcc ttttccagtt
    13441 acttttatag cattcaattt ttctgttagt gtcttaggca tgagcttctc ccttctttgc
    13501 tgcatctgct tccaagcggt ctttgacttg aaccacatcc ttgtccccac gacctgatag
    13561 gcagacaatc atagactttt ctggtccaag ttctttggcc aatttcaccg caaaggcgat
    13621 agcatggcta gattccaagg ctgggataat cccttccaca cgagacaaga gttggaatcc
    13681 ttccaaggct tcttcgtctg tcacagggac atagctggca cgtttaatat cgtggtagtg
    13741 agaatgctct ggaccgatac caggatagtc caaacctgct gagatagaga aggcttcaag
    13801 aatttgacca tgggcatctt ggagcacatc catgagggaa ccgtgaagga cacctggacg
    13861 acccttggtc aaggtagctg cgtggtgctc cgtatccaca ccaagtccag ccgcttcagc
    13921 tccatacatg gctactgact catcttctac aaagggatgg aagagaccaa tggcattcga
    13981 cccaccacca acacaggcta ctagggcatc tggcagattt tgtcctgtca agtcacggta
    14041 ctgttgttta gcctctcgac caatgacact ttggaagtca cgaacaattt ctggaaatgg
    14101 atgaggcccc aaggcagaac caaggatata gtgggtatca tctatattag ccacccatga
    14161 acgaagagct gcattgaccg catccttgag cacgcgcgaa ccatctgtca cggcctcgac
    14221 cttagctccc aaaagctcca tacggaagac attgagggct tggcgtttga catcttcctc
    14281 acccatgtag atggtacatt ccatgttaaa gagggccgca gcagttgcag ttgccacacc
    14341 gtgctgacca gcaccagttt ctgcgataat tttcttttta cccatacgtt tggcaagcca
    14401 aacttgtcct aaggcattgt taatcttgtg ggctcctgta tggttaaggt cttcccgttt
    14461 gagataaatc ttggctccgc cgatatgctg ggtcaagttt tttgcgtagt aaaggggagt
    14521 ttcacgtccc acatactggc gcaaaagttg gtttaattcc tcttggaaac ttgggtctgc
    14581 ctgactttca cggtaggcct tctccaactc caaaactgct gtcatcaatg tttctgggac
    14641 aaaacgtccg ccgaattttc cgtaaaatcc atctttattt ggttcctgat atgccatgct
    14701 ttaccctctc tataaatctt ctaatctttt catgatcttt ttgtccatct gtctccactc
    14761 cgctcgatac atctactgca tagggagtaa aatgttgaat tgcttttact acattatctt
    14821 cattaaggcc acctgcgata aagaagggct gtgctagtcc agtcgtatcc agttgacccc
    14881 aatcaaagga ctgaccactt cctgccacag gggcatcaaa gagtagataa tctgcctgag
    14941 aattggggac atgcccattt ccatctacct gcacagcctg aatactggca caaggcaaat
    15001 tctcaaataa atcatctgcc acctgaccgt gaacttgaac caagtccaag ctaactttgt
    15061 caatcgcttc cagcagttct acccgacttg gtgaaacaaa tactccaacc tttttcacat
    15121 ctgcaggaat aagctttgcc aactcagctg cctcttctaa agtcacctgt cttttactag
    15181 gtgcgaagac aaaaccgata tagtcggctc ctgctgaaac ggctgtttcc accgcttctt
    15241 tggtcgatag tccacaaatc ttaacctttg tcaatctgca actccttgat tctctggacc
    15301 acattttctg cctgcataag agctgtccct accaaaattc cgttaaagta tggggctagt
    15361 cgttccgcat cctgccctgt gaaaatggca gattcagaaa tgtaatagcg accttcctca
    15421 aagtaagggg ctaaatctac actggtctgc aagtcgacct caaaggtagt caagttgcgg
    15481 ttgttgaccc cgataatctc agcaccaagt ctgtgggcta cctctagttc agctagattg
    15541 tgagtctcca ctaagacttc cag
//
LOCUS       DBMVGT010000040        14997 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.040, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000040 DBMVGT010000000
VERSION     DBMVGT010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 14997)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14997)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14997
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.040"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..219
                     /locus_tag="AC0DU4_001376"
     CDS             <1..219
                     /locus_tag="AC0DU4_001376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="HIN4237327.1"
                     /translation="YLTLFVVNIIGSVLIPGISLAGHIGGAVGGAFLAVIFPVRGEKR
                     MYNTSQRLGAVVLFVGLAILLFYKGMGM"
     gene            complement(286..1185)
                     /gene="galU"
                     /locus_tag="AC0DU4_001377"
     CDS             complement(286..1185)
                     /gene="galU"
                     /locus_tag="AC0DU4_001377"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003983 - UTP:glucose-1-phosphate
                     uridylyltransferase activity [Evidence IEA];
                     GO_process: GO:0006011 - UDP-alpha-D-glucose metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HIN4237328.1"
                     /translation="MTSKVRKAVIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVE
                     EALKSGIEDILVVTGKSKRSIEDHFDSNFELEYNLKEKGKTDLLKLVDETTGMRLHFI
                     RQTHPRGLGDAVLQAKAFVGNEPFVVMLGDDLMDITDEKAVPLTKQLMDDYKRTHAST
                     IAVMPVPHDEVSAYGVIAPQGEGKDGLYSVETFVEKPAPEDAPSDLAIIGRYLLTPEI
                     FQILENQAPGAGNEIQLTDAIDTLNKTQRVFAREFTGARYDVGDKFGFMKTSIDYALK
                     HPQVKDDLKNYLIQLGKELTEKE"
     gene            complement(1207..2223)
                     /locus_tag="AC0DU4_001378"
     CDS             complement(1207..2223)
                     /locus_tag="AC0DU4_001378"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000415108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009331 - glycerol-3-phosphate
                     dehydrogenase (FAD) complex [Evidence IEA];
                     GO_function: GO:0047952 - glycerol-3-phosphate
                     dehydrogenase [NAD(P)+] activity [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0046168 - glycerol-3-phosphate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HIN4237329.1"
                     /translation="MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINT
                     HHTNKHYFKDVVLDENIIAYTDLAETLKNVDAILFVVPTKVTRLVAQQVAQTLDHKVI
                     IMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAEETIVRDLTLITAASKD
                     LQTAQYVQELFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAII
                     ARGLAEITRLGVALGASPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIE
                     ANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAE
                     NEWS"
     gene            2435..2875
                     /locus_tag="AC0DU4_001379"
     CDS             2435..2875
                     /locus_tag="AC0DU4_001379"
                     /inference="COORDINATES: protein motif:HMM:NF013540.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237330.1"
                     /translation="MREFGEKIKRLRLAKKISRSEFCGDESELSIRQLIRIENGESRP
                     TLTKLKYIAERLEVEDYKLMPSYIELDKEYLELKYFLMRTPTYEDETIAQKKESVFDK
                     IFEEYYDRLPEEERFIIPNYSYLALANYTVQKLPEKLVEILSFW"
     gene            complement(2998..3441)
                     /locus_tag="AC0DU4_001380"
                     /pseudo
     CDS             complement(2998..3441)
                     /locus_tag="AC0DU4_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001826904.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(3482..4132)
                     /gene="phoU"
                     /locus_tag="AC0DU4_001381"
     CDS             complement(3482..4132)
                     /gene="phoU"
                     /locus_tag="AC0DU4_001381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA];
                     GO_process: GO:0030643 - intracellular phosphate ion
                     homeostasis [Evidence IEA];
                     GO_process: GO:0045936 - negative regulation of phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HIN4237331.1"
                     /translation="MRNQFDLELHELEQSFLGLGQLVLETASKALLALASKDKEMAEL
                     IINKDHAINQGQSAIELTCARLLALQQPQVSDLRFVISIMSSCSDLERMGDHMAGIAK
                     AVLQLKENQLAPDEEQLHQMGKLSLSMLADLLVAFPLHQASKAISIAQKDEQIDQYYY
                     ALSKEIIGLMKDQETSIPNGTQYLYIIGHLERFADYIANICERLVYLETGELVDLN"
     gene            complement(4147..4899)
                     /gene="pstB"
                     /locus_tag="AC0DU4_001382"
     CDS             complement(4147..4899)
                     /gene="pstB"
                     /locus_tag="AC0DU4_001382"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003101281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein
                     PstB"
                     /protein_id="HIN4237332.1"
                     /translation="MGTFSVRHLDLFYGDFQALKNISIQLPERQITALIGPSGCGKST
                     FLKTLNRMNDLVPSCHIEGQVLLDEQDIYSSKFNLNQLRKRVGMVFQQPNPFAMSIYD
                     NVAYGPRTHGIRDKKQLDALVEKSLKGAAIWEEVKDDLKKSAMSLSGGQQQRLCIARA
                     LAVEPDILLMDEPTSALDPISTLKIEDLIQQLKKDYTIIIVTHNMQQASRISDKTAFF
                     LTGEICEFGDTVDVFTNPKDQRTEDYISGRFG"
     gene            complement(4901..5716)
                     /gene="pstA"
                     /locus_tag="AC0DU4_001383"
     CDS             complement(4901..5716)
                     /gene="pstA"
                     /locus_tag="AC0DU4_001383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HIN4237333.1"
                     /translation="MSKYLLKLLVYCFSALTFGSLFLIIGFILIKGLPHLSLSLFSWT
                     YTSENISLMPAIISTVILVFGALLLALPIGIFAGFYLVEYTKKDSLCVKIMRLASDTL
                     SGIPSIVFGLFGMLFFVVFLGFQYSLLSGILTSVIMVLPVIIRSTEEALLSVSDIMRQ
                     ASYGLGAGKLRTVFRIVLPVAMPGILAGVILAIGRIVGETAALMYTLGTSTNTPSSLM
                     SSGRSLALHMYMLSSEGLHVNEAYATGVILIITVLMINTLSSLLSRKLVKGAS"
     gene            complement(5709..6572)
                     /gene="pstC"
                     /locus_tag="AC0DU4_001384"
     CDS             complement(5709..6572)
                     /gene="pstC"
                     /locus_tag="AC0DU4_001384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HIN4237334.1"
                     /translation="MIKQAFKEAVFRAIFFMSATVAVVAILLICFFIFSNGLPFMANY
                     GFARFLLGSDWSPTNIPASYGILPMIVGSLLITLGAIVIGVPTGILTSVFMVYYCPKP
                     VYGFLKSAINLMAAIPSIVYGFFGLQLLVPWIRSFLGNGMSVLTASLLLGIMILPTII
                     SLSESAIRTVPKTYYSGSLALGASHERSIFSVILPAARSGILSAVILGIGRAVGETMA
                     VILVAGNQPIIPSGLFSGTRTLTTNIVLEMAYASGQHREALIATSAVLFFLILLINAY
                     FAYLKGKSSYE"
     gene            complement(6690..7565)
                     /locus_tag="AC0DU4_001385"
     CDS             complement(6690..7565)
                     /locus_tag="AC0DU4_001385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HIN4237335.1"
                     /translation="MKFKKMLTLAAIGLSGFGLVACGNQSAASKQSASGTIEVISREN
                     GSGTRGAFTEITGILKKDGDKKIDNTAKTAVIQNSTEGVLSAVQGNANAIGYISLGSL
                     TKSVKALEIDGVKASRDTVLDGEYPLQRPFNIVWSSNLSKLGQDFISFIHSKQGQQVV
                     TDNKFIEAKTETTEYTSQHLSGKLSVVGSTSVSSLMEKLAEAYKKENPEVTIDITSNG
                     SSAGITAVKEKTADIGMVSRELTPEEGKSLTHDAIALDGIAVVVNNDNKASQVSMAEL
                     ADVFSGKLTTWDKIK"
     gene            complement(7732..9063)
                     /gene="pnpS"
                     /locus_tag="AC0DU4_001386"
     CDS             complement(7732..9063)
                     /gene="pnpS"
                     /locus_tag="AC0DU4_001386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system histidine kinase PnpS"
                     /protein_id="HIN4237336.1"
                     /translation="MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGQGG
                     YWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLKSLAQYVSGLKTKVSQQDQQYKD
                     LAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLV
                     HQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLN
                     LAFVSNASHELRTPVTSIKGFAETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLL
                     TLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVPDDVTLVSDSQLLSQ
                     ILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNK
                     GRSRQTGGTGLGLAIVKELSQLLGGQVTVTSQLGRGSCFTIFLPNQSFAQD"
     gene            complement(9064..9771)
                     /locus_tag="AC0DU4_001387"
     CDS             complement(9064..9771)
                     /locus_tag="AC0DU4_001387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HIN4237337.1"
                     /translation="MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAET
                     EPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMVSAKSDEFDKVLALELGADDYLT
                     KPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
                     LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKA
                     PQFIRTIRGYGYKFKEL"
     gene            complement(9855..10340)
                     /locus_tag="AC0DU4_001388"
     CDS             complement(9855..10340)
                     /locus_tag="AC0DU4_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HIN4237338.1"
                     /translation="MAPTDKEDLIRTLELAPHVEGGYFRQTKKASDTINLAGKGRALY
                     TSIYFLLEETNPSHFHRLTADEIWYFHAGSPLTVHMITADGHYEAVTLGLDISKGQQL
                     HYCVPKGTIWGSTVDKDDALVSCLVAPGFEFEDFELFERVDLLATYPEHKEMIERLTR
                     Y"
     gene            10326..10865
                     /locus_tag="AC0DU4_001389"
                     /pseudo
     CDS             10326..10865
                     /locus_tag="AC0DU4_001389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(11180..12871)
                     /gene="argS"
                     /locus_tag="AC0DU4_001390"
     CDS             complement(11180..12871)
                     /gene="argS"
                     /locus_tag="AC0DU4_001390"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015632348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004814 - arginine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006420 - arginyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HIN4237339.1"
                     /translation="MNTKELIASELSSIIDSLDQEAILKLLETPKNSEMGDIAFPAFS
                     LAKVERKAPQMIAAELAEKMNSQAFEKVVATGPYVNFFLDKSAISAQVLQAVTTEKEH
                     YADQNIGKQENVVIDMSSPNIAKPFSIGHLRSTVIGDSLSHIFQKIGYQTVKVNHLGD
                     WGKQFGMLIVAYKKWGDEEAVKAHPIDELLKLYVRINAEAENDPSLDEEAREWFRKLE
                     NGDEEALALWQWFRDESLVEFNRLYNELKVEFDSYNGEAFYNDKMDAVVDILSEKGLL
                     LESEGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKNEYQFAKSIYVVGQE
                     QSAHFKQLKAVLQEMGYDWSDDITHVPFGLVTKEGKKLSTRKGNVILLEPTVAEAVSR
                     AKVQIEAKNPELENKDQVAHAVGVGAIKFYDLKTDRTNGYDFDLEAMVSFEGETGPYV
                     QYAYARIQSILRKADFKPETAGNYSLNDTESWEIIKLIQDFPRIINRAADNFEPSIIA
                     KFAISLAQSFNKYYAHTRILDESPERDSRLALSYATAVVLKEALRLLGVEAPEKM"
     gene            13007..13453
                     /gene="argR"
                     /locus_tag="AC0DU4_001391"
     CDS             13007..13453
                     /gene="argR"
                     /locus_tag="AC0DU4_001391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HIN4237340.1"
                     /translation="MRKRDRHQLIKKMITEEKLSTQKEIQDRLEAHNVCVTQTTLSRD
                     LREIGLTKVKKNDMVYYVLVNETEKIDLVEFLSHHLEGVARAEFTLVLHTKLGEASVL
                     ANIVDVNKDEWILGTVAGANTLLVICRDQHVAKLMEDRLLDLMKDK"
     gene            13504..>14997
                     /gene="mutS"
                     /locus_tag="AC0DU4_001392"
     CDS             13504..>14997
                     /gene="mutS"
                     /locus_tag="AC0DU4_001392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0030983 - mismatched DNA binding [Evidence
                     IEA];
                     GO_process: GO:0006298 - mismatch repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HIN4237341.1"
                     /translation="MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAA
                     QILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVV
                     KREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTL
                     VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQT
                     ASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLF
                     WLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYD
                     IERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELES
                     LISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTL
                     KIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEG"
BASE COUNT         4432 a         2945 c         3149 g         4471 t
ORIGIN      
        1 tatctgacac tttttgtggt taacattatt ggaagtgttc tgattccagg aatcagccta
       61 gcaggccata tcggtggtgc agttggtggc gcatttctag cagttatctt tccagttaga
      121 ggagaaaaac ggatgtataa caccagccag agattaggag cggtagtctt gttcgtagga
      181 ctcgccattt tgcttttcta caagggaatg ggaatgtgac gaagttgaaa gaaaatttgt
      241 gtaatgaaaa aagataaggc attttttgaa ccttatcttt ttattttatt ccttctcagt
      301 caattctttt ccaagttgga tgaggtaatt cttcaaatca tctttgactt gtggatgttt
      361 gagggcgtag tcaatagatg ttttcataaa gccaaactta tccccaacgt cgtaacgagc
      421 tcctgtaaat tcacgggcaa aaacacgctg tgttttatta agagtatcga ttgcatcagt
      481 aagttggatt tcatttccag caccaggagc ttggttttcg aggatttgga aaatttcagg
      541 cgtgaggagg tagcgtccga taatagcaag gtcgctagga gcgtcctctg gagctggttt
      601 ttcaacaaag gtttcaacac tgtaaagacc atcttttcct tcgccttgcg gagcaataac
      661 cccgtaagca gatacttcgt catgagggac tggcatgaca gcgatagtag acgcgtgggt
      721 acgcttgtag tcatccatga gttgtttggt aagtggaaca gccttttcgt ctgtgatatc
      781 catcaagtca tcaccaagca taacgacaaa aggttcattt ccgacgaaag ccttggcttg
      841 caaaacagca tctccgagac cgcgtggatg agtttggcgg ataaaatgca gacgcatgcc
      901 agttgtttca tcaactagct tcaaaagatc tgttttccct ttttctttga ggttatattc
      961 caattcgaag tttgaatcga agtggtcctc aatagaacgt tttgatttac cagtgacaac
     1021 tagaatatct tcaatacctg atttgagagc ctcttccacg ataaactgga tagttggttt
     1081 gtctacgatt ggcaacattt ctttggcaag ggccttggtt gctggtaaaa atcgagttcc
     1141 tagtccagca gcagggataa ctgcctttct aacttttgat gtcataaaaa tcctttctat
     1201 agagggttaa gaccactcat tttctgcttt aaattcattg ttcatgatgt cataaatggc
     1261 atctttgata ttggttccgt gataaataac ttggtaaata gcctgtgtaa tgggcatata
     1321 gactccaagt tcttgggcta gttcataggc tgctcgagtc gttgaaattc cttcgattac
     1381 catgcccata ttagcttcta tatcagctag ggattctcct cgtccgagag catctccagc
     1441 tctccagtta cgagagtgga tggaagttcc cgttacgatc aaatctccca caccagataa
     1501 gccgctatag gtcaatggac tggccccgag tgctacccct aggcgggtga tttctgctaa
     1561 acctcgagcg atgatggctg ccttagcatt atcaccaaat ccaagaccat gtaaagctcc
     1621 agcaccgaca gcaataatat ttttaagagc accagcagtt tcaaccccga taacatccgt
     1681 attggtataa agtcggaagt agtgattact aaatagctcc tgaacgtatt gagctgtttg
     1741 taaatcttta gaagcagcag ttattaaagt taggtcacgc acaatggtct cttctgcatg
     1801 actaggccct gaaacaacga cgatatcact acggagatgt tcaggaattt cttcttcaag
     1861 aatggttgat aatcgtttat ggctatcagg ttctaatccc tttgatgcgt gcatgatgat
     1921 aaccttatgg tccaaggttt gtgcaacttg ctgggcaaca agtcgtgtca cttttgttgg
     1981 gacaacaaac aaaatcgcat ccacattttt caatgtttct gctaagtcgg tgtaggcaat
     2041 gatattttcg tctagaacga catctttaaa gtagtgctta ttagtatggt gtgtattaat
     2101 ttcattgatt tgctcgggaa gatttcccca aatacgtacc tcgtgtccat tgtcatttaa
     2161 gacttgtgaa agggcggttc cccaagaacc aggccccaag acggcgacgg tttgtttttc
     2221 catgatttcc tccttgatag atttctttct cttattctat catattctag gggattttgc
     2281 acttgcatta ctggggtatg gtggaaaaat acacaaagac cgagatgaag ggataaactc
     2341 ttagtcttta gttaaagtga gaagaaatct gatagatagt ttgattcagt atatgcttat
     2401 aatagaggta aacaactcag gaagttcttg taggttgcga gagtttggcg aaaaaattaa
     2461 aagattacgt ttggctaaaa aaatcagtcg ttcagaattt tgtggtgatg agtctgaatt
     2521 aagtatccgt caattaatta gaattgaaaa tggagaatcc agaccaacac taacaaagtt
     2581 aaaatatatt gctgaacgtt tggaggttga agattacaag ttgatgccaa gttatataga
     2641 gttggataag gaatacctag aattgaagta tttcttgatg aggactccta catacgaaga
     2701 tgaaactatc gcccaaaaga aagagagtgt ttttgataag atttttgaag agtattatga
     2761 taggctacct gaggaagaaa gatttatcat cccaaattat tcatatctag cactagcgaa
     2821 ctacacagtt caaaaattac cagaaaagct agttgaaata ctgtccttct ggtgattttg
     2881 cttaatttct gatgttcgag acatgattga ggagatttgt cttgattttt tcctaaaaaa
     2941 gggcagactc ctcccttggt ttgatgctcg atttttaaaa taaggtgact tattctgtta
     3001 ggcagttttc ccctgccctc tagctctata tggaacaggg agtatcagat ttatctggca
     3061 gattgtatca aataaggctt gaaactgttt tgaataggcg tatagacttg agaatttgag
     3121 aatatgtcgt ctagcagtag agacatattt tccggcaata tgaaggaaga gacgtcgaaa
     3181 acgcttgata gtcaaggcct ttacttcatc accagctagc tgctttaaaa agaggtagag
     3241 attataagcc agacagccca tcatcatacg tacttcattc ttaatcatgg tcgaactatc
     3301 tgtcttatcc ccaaagaatc ctgctttcct ttctttgata aagttttcag cattccctcg
     3361 ttcacgatag aattgaaaca gctcctcact atctacactg cttaaattgg tcaaatgaac
     3421 ttttttacaa ccataaaaaa gagcacttaa tcgtactctt ctcttttaag gattagttga
     3481 attaattcaa atccactagt tctcctgttt ctaggtagac taggcgttca caaatgttag
     3541 caatgtaatc agcgaagcgt tccagatgcc ctatgatata aaggtattga gttccattgg
     3601 gaattgaggt ttcttggtct ttcataagtc caatgatttc ctttgataag gcataataat
     3661 attggtcaat ctgttcatct ttttgagcaa tactaatagc ttttgaggct tggtgcaaag
     3721 gaaaggcaac caataaatcg gctagcatgc tgagggataa tttacccatt tggtgtaact
     3781 gttcttcgtc aggggctagt tgattttctt ttagttgcaa aacagctttg gcaatgcctg
     3841 ccatatggtc tcccatacgt tcaaggtctg aacaagaaga catgatgcta atcacaaatc
     3901 gaaggtcaga cacttgtggc tgctgcaagg ccaacaaacg ggcacaggtc aattcgatag
     3961 cgctttgacc ttggttgata gcatgatcct tattgataat tagctctgcc atctccttgt
     4021 ctttggaggc taaggccagt aaggcttttg aagctgtttc aaggacaagt tgccctagtc
     4081 ctaaaaagga ttgttctaat tcatgcaatt ctaagtcaaa ttgatttctc ataggttttt
     4141 ccttccttat ccgaaccgtc ctgaaatata gtcttctgtg cgctgatctt ttggattggt
     4201 aaacacgtca acggtatctc caaattcgca aatttctcct gttaagaaaa aagcagtttt
     4261 atctgaaata cgtgaagctt gttgcatgtt atgggtaaca atgataatcg tataatcctt
     4321 ttttagttgc tgaatgaggt cttcaatttt taaagtggag atagggtcta aggctgaagt
     4381 cggctcatcc attaacagaa tatcaggttc tactgctaaa gctcgcgcaa tgcaaaggcg
     4441 ttgctgctga ccgccagata aggacatagc actcttttta agatcatctt tgacttcttc
     4501 ccaaatggct gcccctttta aagatttctc cactaaggca tctaattgtt ttttgtctcg
     4561 aataccatgt gtccttgggc cataagccac gttatcatag atagacatgg caaagggatt
     4621 aggctgttga aaaaccatcc ctacacgctt acgtagctga ttaaggttga atttgctact
     4681 ataaatatct tgctcatcta agaggacttg gccttcaata tggcaagaag gaaccaaatc
     4741 gttcatccgg ttaagggttt ttagaaaagt tgatttgcca caaccagatg ggcctatcaa
     4801 ggcagtaatc tgtctttctg gtaattgaat cgaaatattt tttaaggctt gaaaatcccc
     4861 gtaaaataag tctaggtgtc tgactgaaaa tgttcccata ctaggaagct cctttcacaa
     4921 gttttcgaga taataagctt gatagagtat ttatcattaa aacagtaata atcaaaatca
     4981 caccggtagc ataggcttca ttgacatgta gcccctcact tgacagcata tacatatgca
     5041 gggctagaga acgacctgaa gacatgagac tacttggcgt attggtagag gtacctaatg
     5101 tatacatgag ggcagctgtc tcaccaacga tacggccaat agctagtatc actccagcta
     5161 aaatacctgg catggcaact ggtagaacaa ttctaaaaac agtccgtaac ttacctgccc
     5221 caagtccata acttgcttga cgcatgatat cactaacaga taaaagggct tcttctgttg
     5281 agcgaataat gactggcaac accatgatga ctgaggttaa gattcctgat aacagagagt
     5341 attgaaaacc taagaagact acaaagaaga gcatgccaaa cagaccaaaa acaatggaag
     5401 gaatcccaga caaggtatct gaggccaatc gcatgatttt aacacaaagg gaatcttttt
     5461 ttgtatattc cacaagataa aaaccagcaa aaatccctat gggcaaggct aaaagaagag
     5521 caccaaagac cagaataacg gtggaaataa tcgctggcat aagggaaatg ttctcagaag
     5581 tataagtcca agaaaagagg gatagactta gatgaggtaa gcctttgatg aggataaaac
     5641 caatgattaa aaagagagag ccaaaggtta aagctgaaaa acaataaacg agaagtttta
     5701 gcaggtattt actcataaga tgattttcct ttcaagtagg caaagtaggc attaatcaag
     5761 agaataagga aaaagagaac tgctgaggtt gcaataaggg cttccctatg ctgacctgat
     5821 gcgtaagcca tttccagaac aatattggtt gttaaggttc tggttcctga aaagagtcca
     5881 cttggaataa tcggctggtt gcctgccacc aaaataactg ccatggtttc acctactgcg
     5941 cgaccgattc ctaaaataac tgctgataaa ataccagatc tcgcagctgg caagatgaca
     6001 ctaaaaatac tccgttcatg actagctcct agagccaagc taccagaata atacgttttg
     6061 ggaactgttc ggatagcaga ttctgacaaa ctgataatgg ttggcaaaat cattattcct
     6121 aatagtaacg aagcggttag gacactcatg ccatttccta aaaagcttct aatccaaggc
     6181 accaataatt gtaggccgaa aaaaccataa acaatagatg gaatggccgc catcaagttg
     6241 atagctgatt ttaagaagcc atagacgggc tttggacaat aataaaccat aaacaccgat
     6301 gtcaagatgc ctgttggcac cccaatcaca atcgctccta aggtaattaa taaggaacca
     6361 acgatcattg gtaaaatacc atagcttgcc ggaatgttcg ttggcgacca atcactgcct
     6421 aataaaaaac gggcaaagcc gtagttagcc atgaaaggta agccattact aaaaataaag
     6481 aaacagatta gcaaaatagc tacaacagct actgttgcac tcatgaaaaa aattgcccta
     6541 aaaactgctt ctttgaaggc ttgttttatc acatcttgtc ctttctagtg aagaaagtaa
     6601 gggagatacg acacctccct acttgccttc tttatcttat tgtacgatga aacgtctgca
     6661 tctctttaga gatttatgga gcaaacattt tatttaatct tgtcccaggt ggttaatttg
     6721 ccactaaaaa cgtctgcaag ttcagccata ctgacttggc ttgccttatt gtcattattg
     6781 accacaacag caataccgtc taaagcaata gcatcatggg tgagactctt accttcttca
     6841 ggagttaatt ccctagaaac cataccaata tcagcggttt tctccttaac agcggtaata
     6901 cctgctgaag acccattaga ggtaatatca atcgtaactt ctggattttc ttttttataa
     6961 gcttctgcta atttttccat taaagaagat actgaagtgg aacctacaac agacaacttg
     7021 cctgataagt gttggcttgt atattctgtg gtttcagttt tagcttcaat aaatttatta
     7081 tctgtgacca cttgttgacc ttgtttggag tggataaagc tgataaaatc ttgacctagc
     7141 ttggaaagat tagaagacca aacaatgttg aagggacgtt gaagagggta ttcaccatct
     7201 aaaactgtgt ctcgactagc cttgacacca tcaatctcta aagccttgac agatttcgtt
     7261 aaagatccca aggagatgta gccgatagca ttagcattcc cttgaactgc tgagagaaca
     7321 ccttctgtac tattttgaat cacagctgtt ttggcagtgt tgtcaatttt tttatcaccg
     7381 tcttttttga gaatccctgt gatttctgtg aaggcacccc gtgttccaga gccattttct
     7441 cgtgaaatca cctcaatcgt tcctgaagct gactgtttgg aagcagctga ctgattgcca
     7501 caggcaacaa gcccaaatcc tgataagcca atggctgcaa gagtaagcat ttttttgaat
     7561 ttcataataa tcacctttat ctctatgtat ttttcttgtg taggcttact acatttatag
     7621 tctaacaagt ctttgtaaag gtttatccct gattcatgta aagattgtgt aaagaatcaa
     7681 aaaaagccac ttttgaaaaa tggctgctcc taaaaatagc tttaaaaatt attagtcctg
     7741 tgcgaaagat tggttaggaa gaaaaatcgt gaagcaactg cctctgccaa gctgacttgt
     7801 caccgtgact tggccaccta ataattgact gagttctttg acaatggcaa ggccaagacc
     7861 agtgccacca gtttgtctgc ttcgaccttt attaactcgg taaaaacgtt caaaaatacg
     7921 atcctgctct aattgactaa taccaatccc tgtatctgat acagaaatct taatgccttc
     7981 gttcaccttt tgggtcttga cctcaatttt tcccccttgt tcagtgtaac ggatggcatt
     8041 ggataaaaga ttgagtaaga tttgggaaag taattgacta tctgatacga gggtgacatc
     8101 atctggcacc tgcaccttta gctgtaaatc cttcttcttg agctgaggtt gcaagctttg
     8161 agtcaaatcc tgtacaaatt ctgccaaaga aagggtcgtc cattgtatag gcatttgttg
     8221 agccttagat aaggtaagaa gatgctcaac aatatgctca agacgcaagc tttctttgta
     8281 aataatgtct agaaagtcat ccttgagcgc ttcttcttca gcagacatcc ccttaatggt
     8341 ttcagcaaag cccttaatcg aagtaactgg tgtcctcaat tcatgggagg catttgagac
     8401 aaaggctaaa tttaactttt cataagttct aatcgttgtt aaatcatata gcaagacgag
     8461 cacagcttcc acagattggg tggggctaaa aacgggaact gctgtcactt ctaaaatcaa
     8521 gtcaccctca tgaaacccac ttacttcttg ttttaacctt gttttttgat caaaggcttg
     8581 gtgaactaaa tttcgaatat ccatccgttt gaggtcatca agtgaactta tgtcgccgtc
     8641 cacatcggga aaataatgag gcagagagcg actggataat aacatctgac cttgagcgga
     8701 aactaaaaac gtccccatgg ttaggtgcga cagaagaacc tccattgttt cggctaggtc
     8761 cttgtattgc tgatcctgtt gggagacttt ggtttttagg ccagacacat actgagccaa
     8821 agactttaag tcttcttgcc ctttttctaa aaagtattca ctactggtca agagaggttg
     8881 gtgcaaggtc tcaaaagcaa cttcccattt ccaaaggcaa aagagccagt agccaccttg
     8941 tcccaaagaa agggctagaa gaaagagacc gatgccttta ctgatccaag ttaatgccat
     9001 ccctgcaatc agaatgaggc taacacttag attgactagc caaaattgaa ggtagcgttt
     9061 catctataac tccttgaact tataaccata accccgaatg gttcgaataa attgaggggc
     9121 tttaggattg tcttcaattt tttccctcaa cttaccaata tgaacgtcca ccaaacgtgt
     9181 ttcctgccca aagtcatacc cccagatacg ttccaaaaga cgctctctag tcagtgtcat
     9241 gttgggatgt ttcataagat agagcaagag ttcaaattct tttggggtca aactcagtaa
     9301 cttattcgcc ttgtagactt catgacgctc agggtatact ttcaaggtcc caaatagcca
     9361 agaatcgtca gcgatattat ctgaatcatc tccttcttgt tctcctttag ttcgcctgag
     9421 gacagccttg acacgcgcca gcaattctct agggctaaaa ggcttggtca ggtagtcatc
     9481 agcccctaat tccaaggcca aaaccttatc aaattcatca cttttcgcag aaaccatcat
     9541 aattggagtt ttgacgcctt tggctctcag ccgcttacaa acttccatgc catctaattg
     9601 tggtaacatg atatcaagca agataaaatc aaagggttct gtttctgcca aagctaaggc
     9661 cttccgtcca tttgttacca attgagtaga aaagccttcc ttacttaaat ggtagtcaag
     9721 caatttcaga atgtgttctt catcatccac taataagact tgttttgtca tctattatct
     9781 cctattggta acattataac acaattatca gaaatcctaa cattgctaaa tcagattaaa
     9841 tttgcctatc aagactagta tctggtcaaa cgctcaatca tctccttgtg ctctggatag
     9901 gtcgccagta gatctaccct ttcaaataat tcaaaatcct caaattcaaa accaggagca
     9961 acaagacaag aaaccagagc atcatcctta tcaactgttg atccccaaat agtgccctta
    10021 ggaacacagt agtgaagttg ttgccctttg gatatgtcca ggcctaaagt gactgcttcg
    10081 tagtgaccat ctgctgtaat catgtgaaca gtaagtgggg atcctgcatg aaaataccag
    10141 atttcatctg ctgtcaatcg gtgaaaatgt gaaggattcg tttcttctaa taagaaataa
    10201 atactggtat aaagcgccct tcccttacca gcaaggttta tagtgtctga agcttttttt
    10261 gtttgtctaa aatagccacc ttcaacatgg ggagctaact ctagagttct tatcaagtct
    10321 tctttatccg tcggagccaa tgggttgaag taactcttgt tcaaagtggt tttacgattt
    10381 caagaactcc tctcagttct gaggacacgg taatgattga tgcgacggaa gtaaaaatca
    10441 atcgccctaa aaaaagaatt agcgaatgat tctggtaaaa agaaatttca cgctatgaag
    10501 gctcaagcga ttgtcacaag tcaagggaga attgtttcta ttgccatgat atgaagttgt
    10561 tcaaaatgag ttgcagaaat atcggacaag ctggtaaaat cttggctgac agtgattatc
    10621 aagggctcat gaagatatat cctcaagcac aaactccacg taaatccagc aaactcaagc
    10681 cgctaacagc tgaagataaa gcctgtaacc atgcgctatc caaggagaga agcaaggttg
    10741 agaacatctt tgccaaagta aaaacgttta aaatgttttc aacaacctat cgaaatcatc
    10801 gtaaacgctt cggattacga atgaatttga ttgctggtat tatcaatcat gaactaggat
    10861 tctagttttg caggaagtct attatttggt taggtgaatt agtgaagtgt ttaggcaagt
    10921 gtctctggtt acgacgtcat ggcctctaaa tcgattatat ttaggggtca tgactagtga
    10981 agcagttagc tagttcgcat ataagcggct agcgtctaac aattaggaac tttagttcca
    11041 ataactttaa gattacgacg ttttaggaca taaatcgatc atatttatgt cctaaaacta
    11101 gtgaagcgcc tagccaaagt ccgaatagga tttggcgtta gttacttaga ttgctttgca
    11161 atcaagtaac tttggcgatt tacatcttct ctggcgcttc tactccaagc aagcgaaggg
    11221 cttctttgag aacgactgcg gttgcgtagc tgagggctag acggctgtcg cgttctgggc
    11281 tttcatccaa gatacgtgta tgtgcatagt atttgttaaa ggattgagcc aggctaattg
    11341 caaatttagc aatgatagaa ggttcaaagt tatctgccgc acggttgata atacgtggga
    11401 agtcttgaat gagtttaatg atttcccagc tttcagtatc attcaagcta tagttgccag
    11461 ctgtttctgg tttgaaatcg gctttgcgta agatagattg gatacgagcg taggcatatt
    11521 gaacgtaagg tccagtttca ccctcgaagg ataccatagc ttctaggtcg aagtcgtatc
    11581 catttgtacg gtcagttttg aggtcataga atttaatggc tccaacccca acagcatgtg
    11641 ctacttggtc tttgttttct agttcaggat ttttagcctc gatttggacc ttggcacggc
    11701 taacagcctc tgcaacagta ggctctagca agatgacatt ccctttacga gtagagagct
    11761 tcttcccttc ttttgtaacc agaccaaaag gaacgtgggt aatgtcgtca ctccaatcgt
    11821 agcccatctc ttgcaagaca gctttgagtt gtttaaagtg ggcagattgc tcttgaccaa
    11881 cgacgtagat agatttagca aattggtatt catttttacg gtagagggct gcagccaagt
    11941 cacgtgtgat atagagagtt gcaccatcag acttcttgat gagggctgga tgttcaattc
    12001 catatttctc aagattcaca acttgggcac cttctgattc aagaagtagt cctttttcag
    12061 aaagaatgtc tacaactgca tccatcttat cattgtagaa ggcttctccg ttatagctgt
    12121 caaattcaac cttcaattca ttgtaaaggc ggttaaattc cactaaactt tcatcgcgga
    12181 accattgcca aagagcgaga gcttcctcat ctccattttc aagtttacgg aaccattcgc
    12241 gcgcttcttc atccaagcta gggtcatttt cagcttcagc gttgatgcgg acatagagtt
    12301 taaggagttc atcgattgga tgagctttta cagcttcttc gtcgccccat tttttgtagg
    12361 caacaatcaa catcccaaat tgtttacccc agtctcccaa atggttgacc ttgaccgttt
    12421 gataaccgat tttttggaaa atatgtgaca agctatctcc gataacagtt gaacgcaggt
    12481 ggccaataga aaatggttta gcgatattcg gactagacat gtcgataaca acattttctt
    12541 gtttgccaat attttggtca gcatagtgtt ctttttcagt ggtaacagct tgcaatactt
    12601 gagcagaaat ggcagattta tcaaggaaaa agttaacgta aggtcctgtt gcgacaactt
    12661 tttcaaaggc ttggctgttc attttttcag ccagttcagc cgcaatcatt tgtggtgctt
    12721 tacgttcgac ttttgcaaga gaaaaagcag ggaaagcaat gtctcccatt tctgagtttt
    12781 taggggtttc cagtaacttt aaaatagcct cttggtccag gctatcaatg atgctagata
    12841 attcgctagc aatcaattct tttgtattca ttaagagctc ctttttggac ttttctacta
    12901 ttttatcaca attttaaaga aagaagaaaa aatttttgaa atctcctgtt tttttggtat
    12961 aatatggtta taaatatagt tataaatatg cacgcaagag gattttatga gaaaaagaga
    13021 tcgtcatcag ttaataaaaa aaatgattac tgaggagaaa ttaagtacac aaaaagaaat
    13081 tcaagatcgg ttggaggcgc acaatgtttg tgtgacgcag acaaccttgt ctcgtgattt
    13141 gcgcgaaatc ggcttgacca aggtcaagaa aaatgatatg gtgtattatg tactagtaaa
    13201 tgagacagaa aagattgatt tggtggaatt tttgtctcat catttagaag gtgttgcaag
    13261 agcagagttt accttggtgc ttcataccaa attgggagaa gcctctgttt tggcaaatat
    13321 tgtagatgta aacaaggatg aatggatttt aggaacagtt gctggtgcca ataccttatt
    13381 ggttatttgt cgagatcagc acgttgccaa actcatggaa gatcgtttgc tagatttgat
    13441 gaaagataag taaggtcttg ggagttgctc tcaagactta tttttgaaaa ggagagacag
    13501 aaaatggcga tagaaaagtt atcacccggc atgcaacagt atgtggatat taaaaagcaa
    13561 tatccagatg cttttttgct ctttcggatg ggtgattttt atgaattatt ttatgaggat
    13621 gcggtcaatg ctgcgcagat tctggaaatt tccttaacga gtcgcaacaa gaatgccgac
    13681 aatccgatcc ctatggcggg tgttccctat cattctgccc aacagtatat cgatgtcttg
    13741 attgagcagg gttataaggt ggctatcgca gagcagatgg aagatcctaa acaagcagtt
    13801 ggggttgtta aacgagaggt tgttcaggtc attacgccag ggacagtggt cgatagcagt
    13861 aagccggaca gtcagaataa ttttttggtt tccatagacc gcgaaggcaa tcaatttggc
    13921 ctagcttata tggatttggt gacgggtgac ttttatgtga caggtctttt ggatttcacg
    13981 ctggtttgtg gggaaatccg taacctcaag gctcgagaag tggtgttggg ttatgacttg
    14041 tctgaggaag aagaacaaat cctcagccgc cagatgaatc tggtactctc ttatgaaaaa
    14101 gaaagctttg aagaccttca tttattggat ttgcgattgg caacggtgga gcaaacggca
    14161 tctagtaagc tgctccagta tgttcatcgg actcagatga gggaattgaa ccacctcaaa
    14221 cctgttatcc gctacgaaat taaggatttc ttgcagatgg attatgcgac caaggctagt
    14281 ctggatttgg ttgagaatgc tcgctcaggt aagaaacaag gcagtctttt ctggcttttg
    14341 gatgaaacca aaacggctat ggggatgcgt ctcttgcgtt cttggattca tcgccccttg
    14401 attgataagg aacgaatcgt ccaacgtcaa gaagtagtgc aggtctttct cgaccatttc
    14461 tttgagcgta gtgacttgac agacagtctc aagggtgttt atgacattga gcgcttggct
    14521 agtcgtgttt cttttggcaa aaccaatcca aaggatctct tgcagttggc gactaccttg
    14581 tctagtgtgc cacggattcg tgcgatttta gaagggatgg agcaacctac tctagcctat
    14641 ctcatcgcac aactggatgc aatccctgag ttggagagtt tgattagcgc agcgattgct
    14701 cctgaagctc ctcatgtgat tacagatggg ggaattatcc ggactggatt tgatgagact
    14761 ttagacaagt atcgttgcgt tctcagagaa gggactagct ggattgctga gattgaggct
    14821 aaggagcgag aaaactctgg tatcagcacg ctcaagattg actacaataa aaaggatggc
    14881 tactattttc atgtgaccaa ttcgcaactg ggaaatgtgc cagcccactt tttccgcaag
    14941 gcgacgctga aaaactcaga acgctttgga accgaagaat tagcccgtat cgaggga
//
LOCUS       DBMVGT010000041        14662 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.041, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000041 DBMVGT010000000
VERSION     DBMVGT010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 14662)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14662)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14662
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.041"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..191
                     /locus_tag="AC0DU4_001393"
     CDS             <1..191
                     /locus_tag="AC0DU4_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
                     /protein_id="HIN4237342.1"
                     /translation="KPLTVEDKTYNHALSKERSKVENIFAKVETFKMFSTTYRNHRKR
                     FGLRMNLIAGIINHELGF"
     gene            382..2673
                     /gene="pcrA"
                     /locus_tag="AC0DU4_001394"
     CDS             382..2673
                     /gene="pcrA"
                     /locus_tag="AC0DU4_001394"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000992850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase PcrA"
                     /protein_id="HIN4237343.1"
                     /translation="MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYL
                     IDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHI
                     GYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA
                     GDMYTQIVAQCYTTYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVD
                     EYQDTNHAQYQLVKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVL
                     LEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYRADDELDEAVFVART
                     IDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIA
                     YLNLIANLSDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKG
                     KAAQSIWDFANMMLDLREQLDHLSITELVESVLEKTGYVDILNAQATLESKARVENIE
                     EFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMTLHAAKG
                     LEFPVVFLIGMEENVFPLSRATEDSDELEEERRLAYVGITRAEKILYLTNANSRLLFG
                     RTNYNRPTRFINEISSDLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKR
                     GAAPKSIQSSGLPFGQFTAGAKPASSEANWSISDIALHKKWGEGTVLEVSGSGARQEL
                     KINFPEVGLKKLLASVAPIEKKI"
     gene            2716..3396
                     /gene="radC"
                     /locus_tag="AC0DU4_001395"
     CDS             2716..3396
                     /gene="radC"
                     /locus_tag="AC0DU4_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000286923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RadC family protein"
                     /protein_id="HIN4237344.1"
                     /translation="MYSISFQEDSLLPRERLAKEGVEALSNQELLAILLRTGTRQASV
                     FEIAQKVLNNLSSLTDLKKMTLQELQSLSGIGRVKAIELQAMIELGHRIHKHETLEME
                     SILSSQKLAKKMQQELGDKKQEHLVALYLNTQNQIIHQQTIFIGSVTRSIAEPREILH
                     YAIKHMATSLILVHNHPSGAVAPSQNDDHVTKLVKEACELMGIVLLDHLIVSHSNYFS
                     YREKTDLI"
     gene            complement(3393..4082)
                     /locus_tag="AC0DU4_001396"
     CDS             complement(3393..4082)
                     /locus_tag="AC0DU4_001396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HIN4237345.1"
                     /translation="MKKPVIGITGNEKTHPDDDIMMSYAAKGFVEGVKDAGGIPIILP
                     IGDQEMACHYISLIDKLILTGGQNVDPKFYGEPKTIDSDDYHLQRDIFELALIKEAIK
                     QKKPIFSVCRGTQLFNVAMGGTLYQDIEDHWQNSSVEYTTQRLVTEPDTVLQEIYGEI
                     SHINSFHHQSIKDLAPNLKVVAHDPKDGIIEAVMSTDDVAFLGVQWHPELLFENRPKD
                     KKLFDYVVNEL"
     gene            complement(4100..4741)
                     /locus_tag="AC0DU4_001397"
     CDS             complement(4100..4741)
                     /locus_tag="AC0DU4_001397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HIN4237346.1"
                     /translation="MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIG
                     IDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLH
                     YRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTTILTVPSV
                     KSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED"
     gene            complement(4824..5039)
                     /locus_tag="AC0DU4_001398"
     CDS             complement(4824..5039)
                     /locus_tag="AC0DU4_001398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HIN4237347.1"
                     /translation="MFELTYKDCYHVERTLKYEDHEALMLTLSGCVTLPDTLYVTSLT
                     FRGKKVYQGLVGDLYRFLSHADFLHQN"
     gene            complement(5047..5394)
                     /locus_tag="AC0DU4_001399"
     CDS             complement(5047..5394)
                     /locus_tag="AC0DU4_001399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1831 domain-containing protein"
                     /protein_id="HIN4237348.1"
                     /translation="MAFEKIIQLKNCRYDYTLSPSVKKFTLKDNTFFETKVGNYELTR
                     LLEKVPNSGEGFQLKIIINKELTGAKINITDKFGLRLVDIFKSEDHHIHQEKFYFLMD
                     SLVERGVFTKSER"
     gene            complement(5399..6514)
                     /locus_tag="AC0DU4_001400"
     CDS             complement(5399..6514)
                     /locus_tag="AC0DU4_001400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase family protein"
                     /protein_id="HIN4237349.1"
                     /translation="MIYLDNAATTPMSAVAISAMTKVMQETHGNPSSIHGHGRQAGKL
                     LREARQELAQLLRTKPQHIFFTSGGTEGNNTTIIGYCLRHQEQGKHIITTAIEHHAVL
                     ETIDYLVQHFGFEATIIQPKNQEITAQQIQKALRDDTILVSTMFVNNETGNLLPIAEI
                     GQILKQHPAAYHVDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFD
                     SYLHGGDQEQKKRAGTENLPAIVGMVAALKEDLEKQEEHFQHVQNLETAFLAELEGIQ
                     YYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLEAMY
                     GANSERLKESLRISLSPQNTVEDLQTLAKTLKEIIGG"
     gene            complement(6524..7483)
                     /locus_tag="AC0DU4_001401"
     CDS             complement(6524..7483)
                     /locus_tag="AC0DU4_001401"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HIN4237350.1"
                     /translation="MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQ
                     VNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDR
                     IACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD
                     KGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKA
                     ILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDS
                     VATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK"
     gene            complement(7596..8165)
                     /locus_tag="AC0DU4_001402"
     CDS             complement(7596..8165)
                     /locus_tag="AC0DU4_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CYTH domain-containing protein"
                     /protein_id="HIN4237351.1"
                     /translation="MKHLEIELKTLLKKDEYNRLKDQFTGVTPVLQTNYYIDTPDFEL
                     REKRVAMRIRTFEDWAELTLKVPQSVGNMEYNQKLQLKDVENYLSKEELPQGLVLDEL
                     AKHGIQSKNWQVLGCLTTLRYEMKTAIGLMALDQSRYFDMTDYELELEVENHEQGKQD
                     FRQFLEKNQISYQKAPSKLVRFVKSMKNS"
     gene            8293..8964
                     /locus_tag="AC0DU4_001403"
     CDS             8293..8964
                     /locus_tag="AC0DU4_001403"
                     /EC_number="2.7.6.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008728 - GTP diphosphokinase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0015969 - guanosine tetraphosphate
                     metabolic process [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase"
                     /protein_id="HIN4237352.1"
                     /translation="MTLEWEEFLDPYIQAVGELKIKLRGIRKQYRKQNKHSPIEFVTG
                     RVKPIESIKEKMARRGITYATLEHDLQDIAGLRVMVQFVDDVKEVVDILHKRQDMRII
                     QERDYITHRKASGYRSYHVVVEYTVDTINGAKTILAEIQIRTLAMNFWATIEHSLNYK
                     YQGDFPDEIKKRLEITARIAHQLDEEMGEIRDDIQEAQALFDPLSRKLNDGVGNSDDT
                     DEEYR"
     gene            8948..9766
                     /locus_tag="AC0DU4_001404"
     CDS             8948..9766
                     /locus_tag="AC0DU4_001404"
                     /EC_number="2.7.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003951 - NAD+ kinase activity [Evidence
                     IEA];
                     GO_process: GO:0006741 - NADP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD kinase"
                     /protein_id="HIN4237353.1"
                     /translation="MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIV
                     ISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGAR
                     VSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVST
                     PTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRN
                     DYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE"
     gene            9763..10659
                     /locus_tag="AC0DU4_001405"
     CDS             9763..10659
                     /locus_tag="AC0DU4_001405"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HIN4237354.1"
                     /translation="MRFEFIADEHVKVKTFLKKHEVSKGLLAKIKFRGGAILVNNQPQ
                     NATYLLDVGDYVTIYIPAEEGFETLEAIEHPLDILYEDDHFLVLNKPYGVASIPSVNH
                     SNTIANFIKGYYVKQNYENQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQKKSIE
                     KRYFALVKGDGHLEPEGEIIAPIARDEDSIITRRVAKGGKYAHTSYKIVASYGNIHLV
                     YIHLHTGRTHQIRVHFSHIGFPLLGDDLYGGSLEDGIQRQALHCHYLSFYHPFLEQDL
                     QLESPLPDDFSNLITQLSTNTL"
     gene            10703..11677
                     /gene="pta"
                     /locus_tag="AC0DU4_001406"
     CDS             10703..11677
                     /gene="pta"
                     /locus_tag="AC0DU4_001406"
                     /EC_number="2.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008959 - phosphate acetyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006086 - pyruvate decarboxylation to
                     acetyl-CoA [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /protein_id="HIN4237355.1"
                     /translation="MEVFESLKANLVGKNARIVLPEGEEPRILQATKRLVKETEVIPV
                     LLGNPEKIKIYLEIEGIMDGYEVIDPQHYPQFEEMVSALVERRKGKMTEEDVRKVLVE
                     DVNYFGVMLVYLGLVDGMVSGAIHSTASTVRPALQIIKTRPNVTRTSGAFLMVRGTER
                     YLFGDCAININPDAEALAEIAINSAITAKMFGIEPKIAMLSYSTKGSGFGESVDKVVE
                     ATKIAHDLRPDLEIDGELQFDAAFVPETAALKAPGSTVAGQANVFIFPGIEAGNIGYK
                     MAERLGGFAAVGPVLQGLNKPVNDLSRGCNADDVYKLTLITAAQAVHQ"
     gene            complement(12018..12317)
                     /locus_tag="AC0DU4_001407"
     CDS             complement(12018..12317)
                     /locus_tag="AC0DU4_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HIN4237356.1"
                     /translation="MMNMQNMMRQAQKLQKQMEQSQAELAAMQFVGKSAQDLVQATLT
                     GDKKVISIDFNPAVIDPEDLETLSDMTVQAINSALEQIDETTKKKLGAFAGKLPF"
     gene            12719..13423
                     /locus_tag="AC0DU4_001408"
     CDS             12719..13423
                     /locus_tag="AC0DU4_001408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004241810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YoaK family protein"
                     /protein_id="HIN4237357.1"
                     /translation="MGGKMRLLPIRKISRQSKRLALFLTFCAGYVDAYTFIVRGNTLV
                     AGQTGNVVFLSVELIKNNVSDVRDKVLTLLAFMMGVFLLTIYKEKLRIVKKPILSLIP
                     LAILSIIIAFVPQTVDNIYLVPPLAFCMGLVTTAFGEVSGIAYNNAFMTGNIKRTMLA
                     FGDYFRTKHTPFLREGFIFVSLLSSFVLGVVFSAYLTIFYHEKTILGVPIMMSVFYLS
                     MLFASWQKKVKEKASF"
     misc_feature    13482..13569
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00559"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L21 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00559"
     gene            13605..13919
                     /gene="rplU"
                     /locus_tag="AC0DU4_001409"
     CDS             13605..13919
                     /gene="rplU"
                     /locus_tag="AC0DU4_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HIN4237358.1"
                     /translation="MSTYAIIKTGGKQVKVEVGQAVYVEKLNVEAGQEVTFNEVVLVG
                     GENTVVGTPLVAGATVVGTVEKQGKQKKVVTYKYKPKKGSHRKQGHRQPYTKVVINAI
                     NA"
     gene            13935..14279
                     /locus_tag="AC0DU4_001410"
     CDS             13935..14279
                     /locus_tag="AC0DU4_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HIN4237359.1"
                     /translation="MIQAVFERAEDGELRSAEITGHAESGEYGLDVVCASVSTLAINF
                     INSIEKFAGYEPILELNEDEGGYLMVEIPKDLPSHQREMTQLFFESFFLGMANLSENS
                     SEFVQTRVITEN"
     gene            14296..14589
                     /gene="rpmA"
                     /locus_tag="AC0DU4_001411"
     CDS             14296..14589
                     /gene="rpmA"
                     /locus_tag="AC0DU4_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HIN4237360.1"
                     /translation="MLKMTLNNLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVTG
                     GSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK"
BASE COUNT         4311 a         2748 c         3126 g         4477 t
ORIGIN      
        1 tcaagccgct aacagttgaa gataaaacct ataaccatgc gctatctaag gagagaagca
       61 aggttgagaa catctttgcc aaagtagaaa cgtttaaaat gttttcaaca acctatcgaa
      121 atcatcgtaa acgctttgga ttacgaatga atttgattgc tggtattatc aatcatgaac
      181 taggattcta gttttgcagg aagtctattg aggtattgag ctagtttatg aaaaaattgg
      241 gtgaaaagtc gagtgtttta gaaacccaca gtgtagtatt ctagtttcaa tccactatat
      301 tttgctactc cccgtaaagt ttctattttc cctgatttct gatataatag aaatattgac
      361 ttcaagagta aggaagagaa gatgaacgca ttattaaatg gaatgaatga ccgtcaggct
      421 gaggcggtgc aaacgacaga aggtcccttg ctaatcatgg caggagctgg ttctggaaag
      481 actcgtgttt taacccaccg tatcgcttat ttgattgatg aaaagctggt caatccttgg
      541 aatatcttgg ccattacctt taccaacaag gctgcgcgtg agatgaaaga gcgtgcttat
      601 agcctcaatc cagctactca ggactgtctg attgcgacct tccactccat gtgtgtgcgt
      661 attttgcgtc gcgatgcgga ccatattggc tacaatcgta attttacaat tgtggatcct
      721 ggtgaacagc gaacgctcat gaaacgtatt ctcaaacagt tgaacttgga tcctaaaaaa
      781 tggaatgaac gaactatttt ggggaccatt tccaatgcta agaatgattt gattgatgat
      841 gttgcttatg ctgcccaagc tggcgatatg tatacgcaaa ttgtggccca gtgttataca
      901 acctatcaaa aagaacttcg tcagtctgaa tccgttgact ttgatgattt gattatgctg
      961 accttgcgtc tctttgatca aaatcctgat gttttgacct actaccagca aaaattccaa
     1021 tacatccacg ttgatgagta ccaagatacc aaccacgctc agtaccaatt ggtcaaactc
     1081 ttggcttccc gttttaaaaa tatctgtgtg gttggggatg cggaccagtc tatctacggt
     1141 tggcgtggtg ctgatatgca gaatatcttg gactttgaaa aggattaccc caaagccaag
     1201 gttgttttgt tggaggaaaa ttaccgctca accaaaacca ttctccaagc ggccaacgag
     1261 gttattaaaa ataataaaaa tcgccgtcct aaaaatctct ggactcaaaa cgctgatggg
     1321 gagcaaatcg tttactatcg tgccgatgat gagctggatg aggctgtatt tgtagccaga
     1381 accatcgatg aacttagtcg cagtcaaaac ttccttcata aggattttgc agttctctat
     1441 cggactaatg cccagtcccg tacaattgag gaagccctgc tcaagtctaa cattccttat
     1501 accatggttg gtggaaccaa attctacagc cgtaaggaaa ttcgcgatat tattgcttat
     1561 ctcaacctta ttgctaattt gagtgacaat attagttttg agcgtattat caacgagcct
     1621 aaacgtggaa ttggtctagg tacagttgag aaaatccgtg attttgcaaa tttgcaaaat
     1681 atgtctatgc tggatgcttc tgctaatatt atgttgtctg gtatcaaggg taaggcagcc
     1741 caatctatct gggattttgc caatatgatg cttgatttgc gggagcagct agaccactta
     1801 agcattacag agttggttga gtccgtccta gaaaaaacag gttatgtcga tattcttaac
     1861 gcccaagcga ctttagaaag caaggcacgg gttgaaaata tcgaagagtt tctttctgtt
     1921 acgaagaact ttgatgacac cacggatgtg acagaagagg aaactggtct ggacaaactg
     1981 agtcgtttct taaatgactt ggctttgatt gccgacacag attcaggtag tcaggagaca
     2041 tcagaagtga ccttgatgac cctgcatgct gccaaaggtc tcgaatttcc agttgtcttt
     2101 ttgattggga tggaagaaaa tgtctttcca cttagtcgtg cgactgaaga ttcagatgaa
     2161 ttagaagaag agcgccgtct agcctatgta ggtatcacgc gtgcagagaa aattctctat
     2221 ctgaccaatg ccaactcacg cttgcttttt ggtcgtacca attataaccg tccgactcgt
     2281 tttattaacg aaatcagttc agacttgctt gagtatcaag gtctggctcg tcctgcaaat
     2341 acaagcttta aggcatcata tagcagtggt agtatttcct ttggtcaagg tatgagtttg
     2401 gctcaggctc ttcaagaccg taaacgcggt gctgccccaa aatcaatcca gtcaagcggt
     2461 cttccatttg gtcaatttac agctggcgca aaaccagcat ctagcgaggc aaattggtcc
     2521 attagtgata ttgctctcca caagaaatgg ggagagggaa ccgttctgga agtttcaggt
     2581 agcggtgcta ggcaggaatt gaaaatcaat ttcccagaag taggtttgaa aaaactttta
     2641 gccagtgtgg ctccaattga gaaaaaaatc taattttcca tccttctcac gaataataaa
     2701 gtgaggagga tttttatgta cagtatttca ttccaagaag attcactatt accaagagaa
     2761 aggctggcca aggaaggagt tgaagcgctt agtaaccaag agttgctagc tattttactc
     2821 aggacaggaa cacgtcaagc tagcgttttt gaaattgccc aaaaagtctt gaacaatctt
     2881 tcaagcctaa cggatttgaa aaaaatgacc ctgcaggaat tgcagagttt gtctggtatt
     2941 gggcgtgtta aggccataga attacaagct atgattgaac tggggcatcg tattcacaaa
     3001 cacgagactc ttgaaatgga aagtattctc agcagtcaaa agttggccaa gaagatgcag
     3061 caggaattag gggataaaaa acaagagcac ctggtggcac tctatctcaa tactcaaaat
     3121 caaatcatcc atcagcagac catttttatc gggtctgtaa ctcgtagtat cgctgaaccg
     3181 cgagagattc ttcactatgc aatcaagcat atggcgactt ctcttatctt ggtccacaat
     3241 catccttcag gagcggtagc gcctagccaa aatgatgatc atgtcactaa acttgttaaa
     3301 gaagcctgcg aattgatggg gattgttctc ttggaccatt tgattgtctc tcattctaat
     3361 tactttagtt atcgtgaaaa gacagattta atctaaagtt cattaacgac atagtcaaag
     3421 agttttttat ctttgggacg attttcaaaa agaagttctg gatgccattg gacaccgaga
     3481 aaggcgacat catccgtact catgacagcc tcaatgatac catctttagg atcatgagcc
     3541 acaactttta aatttggtgc taagtccttg atgctctggt ggtggaagga gttgatatga
     3601 gagatttctc catagatttc ttggagaacg gtatctggtt ctgttaccaa gcgttgagtt
     3661 gtgtactcaa cagaagaatt ctgccaatgg tcttcgatat cttggtacaa agttccaccc
     3721 atggcaacgt taaagagttg ggtaccacgg cagacagaga aaatgggctt tttctgttta
     3781 atagcttcct tgatgagggc cagttcgaag atatctcttt gaaggtgata gtcatcgcta
     3841 tcaatggttt tgggttcgcc ataaaatttt ggatcgacat tttgcccacc tgtcaagatg
     3901 agcttgtcaa tcaaactgat atagtggcag gccatttctt gatcaccaat cggtaggatg
     3961 atgggaatcc ctccagcatc tttaacgcct tcaacaaagc cttttgctgc gtagctcatc
     4021 atgatgtcat catctggatg agttttttcg tttcctgtaa tcccaataac tggttttttc
     4081 ataaaatgat tttcgctttc taatcctctt ttcgcatgaa gtagaggagg gtttggagtt
     4141 cacttgtcaa atcgacatac tgaacgacca cgtcttttgg taaatgcaga tggactggtg
     4201 aaaaactgag aattcctttc acaccagcat caaccaagag attagcaacc tcttgtgact
     4261 tgacgctggg aacagttagg atagtagtct tcacatcagc atccttgatt ttatccttga
     4321 tctgagaaat cccgtaaatg ggaatcccgt caggagtttg ggtaccgact tcaggatggt
     4381 cgtctaggtc aaaggccatg ataatcttca tcttgttacg ttcgtggaag cggtagtgga
     4441 gaagggcatg gcccatattt ccaataccaa ccagcatgac attggtaata gagttgtcat
     4501 tgagcaaatc ggcaaaaaat gtcattagtt ttttgacatc atagccaaaa ccacgacgac
     4561 caagttcacc aaaataggaa aaatcacgac gtacggtcgc tgaatcaata ccgatagcct
     4621 ctgcaatttg cttagagttg gcacgttcaa tcttttctgc atgaaatctc ttaaaaattc
     4681 gatagtagag agagagtctt tttgctgtag cttttggaat agcaaactgt ttatctttca
     4741 caaaatcaca acctttctat tcttctattt tatagaaaca ttgtgaaaaa atcaacaaaa
     4801 ataagaaaaa actaagaaaa atcttagttt tgatgtaaaa aatctgcatg agatagaaaa
     4861 cggtagaggt ctccgaccag cccctgataa acttttttgc ccctaaaagt cagagaagtc
     4921 acataaagtg tatctggtaa ggttacacat cctgacaaag tcaacatgag agcctcatga
     4981 tcctcatact tgagagtacg ctctacatga tagcagtcct tataggtcag ttcaaacatt
     5041 ttggctctat ctttccgatt ttgtaaagac accacgttct accaagctat ccatgaggaa
     5101 gtagaatttt tcctgatgaa tatggtggtc ttctgatttg aaaatatcaa ctagacgaag
     5161 gccaaacttg tcagtgatat tgattttagc ccctgtaagt tccttgttaa tgatgatttt
     5221 gagttggaag ccttcaccgc tgtttggcac tttttccaaa aggcgagtca gttcatagtt
     5281 accaacctta gtttcaaaaa aggtgttatc tttgagggtg aattttttaa cagaagggct
     5341 aagagtgtaa tcgtaacgac aattttttaa ctgaatgatt ttttcaaatg ccatatggct
     5401 aacctccgat aatttctttt aaggtttttg cgagggtttg taggtcttca acggtatttt
     5461 gtggcgacaa actgatgcga agggattcct tcaagcgttc tgaatttgcg ccatacatgg
     5521 cttcaagaac atggctggat tggacaacgc ctgcagtaca ggctgagcca gtagagattg
     5581 aaattccagc taaatctagc cgaaggagta agaggtcatt tttctgacca ggaaatccaa
     5641 tattgagaac ataagggaga tgatgttttc ctctattcag gtaatactga atgccctcca
     5701 gctctgccag aaaggcagtt tctagatttt gtacatgttg aaaatgttct tcttgttttt
     5761 ctaggtcttc ttttagggct gcaaccatgc ctacaatggc aggcagattt tcagttcctg
     5821 cacgtttttt ctgttcctgg tctccgccat gtagatagga atcaaagtcc atgctagatg
     5881 cgtagagaaa accgattccc ttaggaccat ggaatttgtg ggcagaagca gtgagaaaat
     5941 caatgcccaa ttcttctgaa tgaattggga ttttaccaat agcctgaact gcatcaacat
     6001 gataggcagc agggtgttgc ttgagtattt ggccaatttc agcgatgggc agtaggtttc
     6061 ctgtctcatt attgacaaac atggtagaaa ccaaaatcgt atcgtcacgt aaagcctttt
     6121 gaatttgctg ggctgtgatt tcttgatttt ttggctggat aatggttgct tcaaacccaa
     6181 agtgttgaac caagtaatca attgtttcaa ggacagcatg gtgctcgatg gcagttgtga
     6241 tgatatgttt tccttgttct tggtgacgaa gacagtagcc aatgatggta gtattattgc
     6301 cttcagtccc accagaagtg aaaaagatat gttgaggttt tgtccttagt aactgggcta
     6361 gttcctgacg ggcttctcgt aagagtttgc cagcttgacg accatgacca tgaatactag
     6421 aaggatttcc gtgggtttct tgcataacct tggtcatagc tgaaatagca actgctgaca
     6481 taggagtcgt tgcagcattg tccaaataaa tcaaagaatc accttatttc tttttattgt
     6541 aggcaaagag tgggctgact ggttttcttt cgtgaatacg gacgatagca tcaccaatta
     6601 actcactagc agtgatgtag catacatttt taggagtttt ttcttttgtt gctactgaat
     6661 cagtcacaag aatttcttta atattagtat tgtcaagaag ctcagcagct ccctcgacga
     6721 agagaccgtg gctagaaaca gcataaattt ctgtagctcc ttcacgttca acgattttag
     6781 aagcttcaga gaaggtacgt cctgtattta aaatatcatc aatcaagata gctttcttac
     6841 cttcaacatc accaataata taaccttcgt tacgagttgc atcgtcttga gggtagtcga
     6901 taatggcgat aggagcatca agatattcag ccaggctacg cgcacgtttg acacctgaat
     6961 ttttagggct aacgacaaca acatctgaac caagcaatcc tttatcgcag taatgttttg
     7021 cgaatagggg aacagtgaaa agattatcca ctggaatatc aaagaaacct tgaacctgaa
     7081 cggcatgcaa atcaagagtc aggatacgat caactccagc cttaaccagc atattggcaa
     7141 ctagttttgc tgtaagtggc tcacgaggac aagcaatgcg gtcttgacgt gcatagccaa
     7201 aatatggaag gacaacgttg atactgtggg cacttgcacg cacacaagca tcgaccatga
     7261 ttaacaattc cattaggtgg ttgttgacag ggaaacttgt tgattggatg atgtaaacat
     7321 cataaccacg gacactttct tcgatattta cttggatttc tccgtctgaa aattgacgtg
     7381 atgatagttt tccaagtggg acaccaacag cttgggcaat tttctgtgca atctcttggt
     7441 tagagttgag tgcgaaaagt ttcatgtttt ttctatctga cattatagac cgtcctctgt
     7501 aaactttata aatcctagtt atatttacct tacatatatg aactggggtt tgtgtatttt
     7561 tatcttttct attttaccaa aaaatggaga ttatttcagc tatttttcat acttttgaca
     7621 aatcgaacca attttgaagg agctttttgg taggaaatct gatttttctc taaaaattgt
     7681 cggaaatcct gtttgccttg ctcatgattt tccacttcaa gctccaattc gtaatctgtc
     7741 atatcaaagt atcggctctg atccagtgcc atgagaccaa tagctgtttt catttcatag
     7801 cgaagcgttg ttagacaacc aagaacctgc cagttcttac tttggatacc atgtttcgcc
     7861 aattcatcca gtactagccc ttgaggaagt tcttccttac tcagatagtt ctcaacatct
     7921 tttagttgca atttttggtt gtattccatg tttccaacac tctgcgggac tttgagtgtc
     7981 aactcagccc agtcttcaaa ggttcgaatg cgcatagcga ctctcttttc tcgcagttca
     8041 aaatcaggcg tgtctatgta gtaatttgtt tgaagaacag gagtgacacc tgtgaactgg
     8101 tcttttagac gattgtattc atcttttttc aatagtgttt tcaattcaat ttctaaatgt
     8161 ttcatttttc ttaccttttt ttatcgttga aagcggattt atggtataat aagcattgta
     8221 tttattgtat atgaatctgg agaaaaaatc aaagatattt ttgacggata atatgagaac
     8281 aagggagaat atatgacctt agaatgggaa gaatttctag atccttacat tcaagctgtt
     8341 ggtgagttaa agattaaact tcgtggtatt cgtaagcaat atcgtaagca aaataagcat
     8401 tctccaattg agtttgtgac cggtcgagtc aagccaattg agagcatcaa agaaaaaatg
     8461 gctcgtcgtg gcattactta tgcgaccttg gaacacgatt tgcaggatat tgctggctta
     8521 cgtgtgatgg ttcagtttgt agatgacgtc aaggaagtag tggatatttt gcacaagcgt
     8581 caggatatgc gaatcataca ggagcgagat tacattactc atagaaaagc atcaggctat
     8641 cgttcctatc atgtggtagt agaatatacg gttgatacca tcaatggagc taagactatt
     8701 ttggcagaaa ttcaaattcg tactttggcc atgaatttct gggcaacgat agaacattct
     8761 ctcaactaca agtaccaagg ggatttccca gatgagatta agaagcgact ggaaattaca
     8821 gctagaatcg cccatcagtt ggatgaagaa atgggtgaaa ttcgtgatga tatccaagaa
     8881 gctcaggcac tttttgatcc tttgagtaga aaattaaatg acggtgtagg aaacagtgac
     8941 gatacagatg aagaatacag gtaaacgaat tgatctgata gccaatagaa aaccgcagag
     9001 tcaaagggtt ttgtatgaat tgcgagatcg tttgaagaga aatcagttta tactcaatga
     9061 taccaatccg gatattgtca tttccattgg cggggatggt atgctcttgt cggcctttca
     9121 taagtacgaa aatcagcttg acaaggtccg ctttatcggt cttcatactg gacatttggg
     9181 cttctataca gattatcgtg attttgagtt ggacaagcta gtgactaatt tgcagctaga
     9241 tactggggca agggtttctt accctgtttt gaatgtgaag gtctttcttg aaaatggtga
     9301 agttaagatt ttcagagcac tcaacgaagc cagcatccgc aggtctgatc gaaccatggt
     9361 ggcagatatt gtaataaatg gtgttccctt tgaacgtttt cgtggagacg ggctaacagt
     9421 ttcgacaccg actggtagta ctgcctataa caagtctctt ggcggtgctg ttttacaccc
     9481 taccattgaa gctttgcaat taacggaaat tgccagcctt aataatcgtg tttatcgaac
     9541 actgggctct tccattattg tgcctaagaa ggataagatt gaacttattc caacaagaaa
     9601 cgattatcat actatttcgg ttgacaatag cgtttattct ttccgtaata ttgagcgtat
     9661 tgagtatcaa atcgaccatc ataagattca ctttgtcgcg actcctagcc ataccagttt
     9721 ctggaaccgt gttaaggatg cctttatcgg tgaggtggat gaatgaggtt tgaatttatc
     9781 gcagatgaac atgtcaaggt taagaccttt ttaaaaaagc acgaggtttc taagggattg
     9841 ctggccaaga ttaagtttcg aggtggagct attctggtca ataatcaacc gcaaaatgca
     9901 acgtatctat tggacgttgg agactacgtt accatttaca ttcccgctga ggaaggcttt
     9961 gaaaccttgg aggctattga gcatccatta gatattctct atgaggatga ccactttcta
    10021 gtcttgaata aaccctatgg agtggcttct attcctagtg tcaatcactc taataccatt
    10081 gccaatttta tcaagggtta ctatgtcaag caaaattatg aaaatcagca ggttcacatt
    10141 gttaccagac tagataggga cacttctggc ttgatgctct ttgccaagca cggttatgcc
    10201 catgcacgat tagacaagca gttgcagaag aaatctatcg agaaacgcta ctttgctttg
    10261 gttaagggag atggacattt ggagccagaa ggggaaatta ttgctccgat tgcgcgtgat
    10321 gaagattcca ttattaccag acgagtggct aaaggcggaa agtatgccca tacttcatac
    10381 aagattgtag cttcttatgg aaatattcac ttggtctata ttcacctgca cactggtcga
    10441 acccatcaaa tccgagtcca tttttctcat atcggttttc ctttgctggg agatgatttg
    10501 tatggtggta gtctggaaga tggtattcaa cgtcaggctc tgcattgcca ttacctatcc
    10561 ttttatcatc catttttaga gcaagacttg cagttagaaa gtcccttgcc ggatgatttc
    10621 agtaacctta ttacccagtt atcaactaat actctataaa aactgtctca gagtataatt
    10681 attatcttaa aggagaaaac tcatggaagt ttttgaaagt ctcaaagcca accttgttgg
    10741 taaaaatgct cgtatcgttc tccctgaagg ggaagagcct cgtattcttc aagcaacaaa
    10801 acgcttagta aaagaaacag aagtgattcc tgttttgctt ggaaatcctg aaaaaattaa
    10861 aatttatctt gaaattgaag gaatcatgga tggttatgag gtcatcgacc ctcaacatta
    10921 tcctcaattt gaagaaatgg tttctgcctt ggtggagcgt cgcaagggca aaatgactga
    10981 agaagatgta cgcaaggttt tggttgaaga tgtcaactac tttggtgtga tgttggttta
    11041 cttgggcttg gttgatggaa tggtgtcagg agcgattcac tcaacagctt caacagttcg
    11101 tccagctcta caaatcatca aaactcgtcc aaatgtaact cgtacttcag gagccttcct
    11161 catggttcgt ggtacggaac gttacctatt tggagactgt gccattaaca tcaatccaga
    11221 tgcagaagcc ttggctgaaa ttgccatcaa ctcagcaatc acagctaaga tgtttggcat
    11281 cgaacctaaa attgccatgt tgagctattc tactaaaggt tcagggtttg gtgaaagcgt
    11341 tgataaggtc gttgaagcaa ctaaaattgc tcacgacttg cgtcctgacc ttgaaatcga
    11401 tggtgagttg caatttgatg cagcctttgt tcctgaaact gcagctctga aagctcctgg
    11461 aagtacggta gctggtcaag caaatgtctt catcttccca ggtatcgagg caggaaatat
    11521 cggttacaag atggctgaac gcctgggtgg ctttgcggct gtaggacctg ttttgcaagg
    11581 tttaaacaag ccagttaatg atctttctcg tggatgtaat gcagatgatg tttacaagtt
    11641 gaccctcatc acagcagctc aagcagttca tcaatagtga aaactataaa gcgatatact
    11701 atgctatact gtagttatga aactatgtac gaaaagcact gccattaatt cctgagaact
    11761 aaattactga ttggtgtcaa aaaggaaaac ttccaagcga tgatatcctg tttatacacg
    11821 acctatagaa atctgtaata tgtatgtccg taaaacgata atttcccttt ttgattttaa
    11881 atgagtatga aaagagaatt tttcatgaga aaacgcataa tattaagtgt cttgacacct
    11941 gctattatgc gttttttata atttttgcac ctttcttagc ctttgttatc gacaagtatt
    12001 gttctagctc cttgttttta gaatggcaat ttcccagcga aagcacccag ttttttctta
    12061 gtagtttcat cgatttgttc aagagcagag ttgatggctt gaacggtcat atcagaaaga
    12121 gtttcaaggt cctctgggtc aatgacagct ggattgaaat caatgctgat aactttctta
    12181 tctccagtta aggtcgcttg gacaagatct tgagcagatt tgccaacaaa ttgcatagca
    12241 gcaagttcag cttggctttg ttccatttgt ttttgaagtt tttgtgcttg acgcatcatg
    12301 ttttgcatgt tcatcataag atttctaaag ttcctttcat ctcaagggga taatccttgt
    12361 tgttaacaag tgcctgattt tctctcctaa ttgttattag tagcatagcc atcaagccca
    12421 agtattgatt ttattatacc atttttttaa gacatagtct tttattggtg agagttattt
    12481 atgtcaagga gtgattagaa ataaattaaa ataatgattt ttgctaagag ggctctattc
    12541 tagtttcatg gaaatgattt tactaaaggt tcgtatgctt tgtttgcaaa catgttacat
    12601 ctatctattt ttggataaat agttgtctat tattattttt atgctaatag taaaatctaa
    12661 atggtagcct acgatttttt agaaagaaaa tggtacaata tttctaagag aaaatacaat
    12721 gggaggtaaa atgaggttat tacctataag aaaaatatca cgtcagtcta aaaggttagc
    12781 actttttttg acgttttgtg ctggatatgt ggatgcttac acttttattg ttcgcgggaa
    12841 tacccttgta gctggacaaa ctggaaatgt tgtctttctt tcagtagaat taattaaaaa
    12901 taatgtttcg gatgttaggg acaaggttct caccttgcta gcgtttatga tgggagtctt
    12961 tttattaacg atttataagg aaaaattgag aattgtgaaa aaacctattc tgtccttgat
    13021 tcccttggca atcttatcaa tcattattgc ttttgtgccg caaactgtgg ataatatcta
    13081 tctagtgccg cccttggcct tctgtatggg actggtgaca actgcttttg gagaagtgtc
    13141 gggtattgcc tataataacg cttttatgac agggaatatc aaacggacca tgctggcttt
    13201 tggagattat ttccgaacca agcacactcc ttttttgcgt gaaggattca tatttgttag
    13261 cctgcttagt agttttgtcc ttggcgttgt cttttcagcc tatttgacga ttttctatca
    13321 tgaaaagacc attcttggtg ttcctattat gatgagcgtt ttttacctca gcatgctttt
    13381 tgcctcttgg cagaaaaaag taaaagaaaa agcttcattt taggtgttat tacttgtaag
    13441 aaaataggag atatgctata cttgaagagt tgactatgca cgatcctgtg caaccgcacg
    13501 aacatcgttg cttgattatt caagtttaag tggttcgtcc cacgatgcta ggcgagtctt
    13561 cacaaaaaat cggggaaacc cataaaaatc ataggaggtg cataatgagc acatacgcaa
    13621 ttatcaaaac tggcggaaaa caagttaaag ttgaagttgg tcaagcagtt tacgttgaaa
    13681 aattgaacgt tgaagctggt caagaagtta cttttaacga agttgttctt gttggtggtg
    13741 aaaacactgt tgtcggaact ccacttgttg ctggagctac tgtagttgga actgttgaaa
    13801 aacaaggaaa acaaaagaaa gtggttactt acaagtacaa acctaaaaaa ggtagccacc
    13861 gtaaacaagg tcaccgtcaa ccatatacaa aagttgtcat caacgcaatc aacgcttaat
    13921 tttaaggaga acacatgata caggcagtct ttgagagagc cgaagatggc gagctgagga
    13981 gtgcggaaat tactggacac gccgagagtg gcgaatacgg cttagatgtc gtgtgtgcat
    14041 cggtttctac gcttgccatt aactttatca attctattga gaaatttgca ggctatgaac
    14101 caatcctaga attaaacgaa gatgaaggtg gctatctgat ggttgaaata ccaaaagatc
    14161 ttccttcaca ccagagagaa atgacccagt tattctttga atcatttttc ttaggtatgg
    14221 caaacttatc ggagaactct tctgagttcg tccaaaccag agttatcaca gaaaactaac
    14281 acggaggaaa acattatgtt aaaaatgact cttaacaact tgcaactttt cgcccacaaa
    14341 aaaggtggag gttctacatc aaacggacgt gattcacaag cgaaacgtct tggagctaaa
    14401 gcagctgacg gacaaactgt aacaggtgga tcaatccttt accgtcaacg tggtacacac
    14461 atctatccag gtgtaaacgt tggtcgtggt ggagacgata ctttgttcgc taaagttgaa
    14521 ggcgtagtac gctttgaacg taaaggacgc gataaaaaac aagtttctgt ttacccaatc
    14581 gctaaataaa aaggtccatt gaacctttta tcccgaacct tgaaatataa aggtgaggaa
    14641 gctagaaaca gcttaaaata ag
//
LOCUS       DBMVGT010000042        14157 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.042, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000042 DBMVGT010000000
VERSION     DBMVGT010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 14157)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14157)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14157
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.042"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..399
                     /locus_tag="AC0DU4_001412"
     CDS             <1..399
                     /locus_tag="AC0DU4_001412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HIN4237361.1"
                     /translation="KVSGRRYQRISLVAGLTNGELIAPMTYEEMMTSDFFEAWFQKFF
                     LPTLTTPSVIIMDNVRFHRMGKNVRFHRMGKLELLCEEFGHKLLPLPPYSPEYNPIEK
                     TWAHIKKHLKKVLPSCNTFYEALLSCSCFN"
     gene            complement(601..2859)
                     /locus_tag="AC0DU4_001413"
     CDS             complement(601..2859)
                     /locus_tag="AC0DU4_001413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HIN4237362.1"
                     /translation="MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSL
                     FKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPPTQSGGGYGGNGGYGSQNRGSAQ
                     TPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
                     GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEI
                     RKREDIILFIDEIHEIVGAGSASDGNMDAGNILKPALARGELQLVGATTLNEYRIIEK
                     DAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAAIEAAATLSNRYIQD
                     RFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRD
                     QIAKYKEMQKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKS
                     HVIGQDDAVDKIAKAIRRNRVGLGTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSA
                     DSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDEVEKAHP
                     DVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSV
                     LGELGNFFSPEFMNRFDGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKV
                     KEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENPSEKDLKAVMTSKGNIQIKSA
                     KKAEVKSSEKEK"
     gene            complement(3088..3318)
                     /locus_tag="AC0DU4_001414"
     CDS             complement(3088..3318)
                     /locus_tag="AC0DU4_001414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005592360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1797 family protein"
                     /protein_id="HIN4237363.1"
                     /translation="MESHLVRIINRLEAMANDGGNLKRNFEREGVVVAEVAYSHDEEN
                     GPIFTLRDVEDRETYTFDSIDLIAMEIYELLY"
     gene            3508..4191
                     /locus_tag="AC0DU4_001415"
     CDS             3508..4191
                     /locus_tag="AC0DU4_001415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001011621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HIN4237364.1"
                     /translation="MNFSFLPKYLPYFNYGAVVTILISICVIFLGTILGVVLAFGQRS
                     KFKPLVWLANLYVWIFRGTPMMVQIMIAFALMHINAPTIQIGILGVDFSRLIPGILII
                     SMNSGAYVSETVRAGINAVPKGQLEAAYSLGIRPKNAMRYVILPQAVKNILPALGNEF
                     ITIIKDSSLLSAIGVMELWNGATTVSTTTYLPLTPLLFAAFYYLIMTSILTVALKAFE
                     KHMGQGDKK"
     gene            4191..4925
                     /locus_tag="AC0DU4_001416"
     CDS             4191..4925
                     /locus_tag="AC0DU4_001416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015424 - ABC-type amino acid transporter
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HIN4237365.1"
                     /translation="MTETLIKIENLHKSFGKNEVLKGINLEIKRGEVVVIIGPSGSGK
                     STLLRSMNLLEEATKGKLIFEGVDITDKKNDLFAMREKMGMVFQQFNLFPNMTVMENI
                     TLSPIKTKGESREVAEKRAQELLEKVGLPDKADAYPQSLSGGQQQRIAIARGLAMEPD
                     VLLFDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAREVADRVIFMADGVV
                     VEDGTPEQIFEQTQEQRTKDFLSKVL"
     gene            5079..5936
                     /locus_tag="AC0DU4_001417"
     CDS             5079..5936
                     /locus_tag="AC0DU4_001417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000192112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="HIN4237366.1"
                     /translation="MTQIIDGKALAAKLQGQLAEKTAKLKEETGLVPGLVVILVGDNP
                     ASQVYVRNKERSALAAGSRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPK
                     HIDEEAVLLAMDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKN
                     AVVIGRSNIVGKPMAQLLLAKNATVTLAHSRTHNLAKVAAKADILVVAIGRAKFVTAD
                     FVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQ
                     AALRTLDRK"
     gene            6078..6950
                     /locus_tag="AC0DU4_001418"
     CDS             6078..6950
                     /locus_tag="AC0DU4_001418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000864675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016836 - hydro-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-hydrate dehydratase"
                     /protein_id="HIN4237367.1"
                     /translation="MKVINQTLLEKVIIERSRSSHKGDYGRLLLLGGTYPYGGAIIMA
                     ALAAVKSGAGLVTVGTDRENIPALHSHLPEPMAFSLQDQQLLKEQLEKAEVVLLGPGL
                     RDDASGENLVKQVFVNLSQNQILIVDGGALTILARTSLSFPSSQLILTPHQKEWEKLS
                     GITIEKQKEDATASVLTSFPQGTILVEKGPATRIWEVGQSDYYQLQVGGPYQATGGMG
                     DTLAGMIAGFVGQFRQASLYERVAVATHLHSAIAQELSQENYVVLPTEISRYLPKIMK
                     IICQQERVSKDKLV"
     gene            7232..7915
                     /gene="rpiA"
                     /locus_tag="AC0DU4_001419"
     CDS             7232..7915
                     /gene="rpiA"
                     /locus_tag="AC0DU4_001419"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004751 - ribose-5-phosphate isomerase
                     activity [Evidence IEA];
                     GO_process: GO:0009052 - pentose-phosphate shunt,
                     non-oxidative branch [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-5-phosphate isomerase RpiA"
                     /protein_id="HIN4237368.1"
                     /translation="MENLKKMAGIKAAEFVSDGMVVGLGTGSTAYYFVEEIGRRIKEE
                     GLQITAVTTSSVTTKQAEGLNIPLKSIDQVDFVDVTVDGADEVDSQFNGIKGGGGALL
                     MEKVVATPSKEYIWVVDESKLVEKLGAFKLPVEVVQYGAEQVFRHFERAGYKPSFREK
                     DGQRFVTDMQNFIIDLALDVIENPIAFGQELDHVVGVVEHGLFNQMVDKVIVAGRDGV
                     QISTSKKGK"
     gene            7929..9140
                     /locus_tag="AC0DU4_001420"
     CDS             7929..9140
                     /locus_tag="AC0DU4_001420"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019318858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000287 - magnesium ion binding [Evidence
                     IEA];
                     GO_function: GO:0008973 - phosphopentomutase activity
                     [Evidence IEA];
                     GO_process: GO:0009117 - nucleotide metabolic process
                     [Evidence IEA];
                     GO_process: GO:0043094 - metabolic compound salvage
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HIN4237369.1"
                     /translation="MSKFNRIHLVVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISK
                     TVGLNVPNMAKIGLGNIPRETPLKTVAAESNPTGYATKLEEVSLGKDTMTGHWEIMGL
                     NITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIDDFGPRQMETGELII
                     YTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFTRT
                     ANRRDLAVSPFSPTVLDKLNEAGIDTYAVGKINDIFNGAGINHDMGHNKSNSHGIDTL
                     LKTMGLAEFEKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDERLPEIIAAMRENDLL
                     LITADHGNDPTYAGTDHTREYIPLLAYSPAFKGNGLIPVGHFADISATVADNFGVETA
                     MIGESFLDKLV"
     gene            9142..9684
                     /locus_tag="AC0DU4_001421"
     CDS             9142..9684
                     /locus_tag="AC0DU4_001421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1697 domain-containing protein"
                     /protein_id="HIN4237370.1"
                     /translation="MTRYSLLVRGINVGGKNKVVMAELRQELTNLGLEKVESYINSGN
                     IFFTSIDSKAQLVEKLETFFAVHYPFIQSFSLLSLEDFEAELENLPAWWSRDLARKDF
                     LFYTEGLDVDQVIATVESLELKDEVLYFGKLGIFWGKFSEESYSKTAYHKYLLKVPFY
                     RHITIRNAKTFDKIGQMLKK"
     gene            9700..10509
                     /locus_tag="AC0DU4_001422"
     CDS             9700..10509
                     /locus_tag="AC0DU4_001422"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004731 - purine-nucleoside phosphorylase
                     activity [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HIN4237371.1"
                     /translation="MTFLNKIHETATFLKEKGIAAPEFGLILGSGLGELAEEIENPVV
                     VDYAEIPNWGRSTVVGHAGKLVYGELAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKV
                     LGCEGVIVTNAAGGIGFGPGTLMAISDHINMTGQNPLMGENLDDFGPRFPDMSRAYTP
                     EYRATAHEVAKKLNIKLDEGVYIGVTGPTYETPAEIRSYKTLGADAVGMSTVPEVIVA
                     AHSGLKVLGISCITNFAAGFQEELNHEEVVEVTERVKGGFKGLLKAILAEL"
     gene            10985..11380
                     /locus_tag="AC0DU4_001423"
     CDS             10985..11380
                     /locus_tag="AC0DU4_001423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000887334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lipase family protein"
                     /protein_id="HIN4237372.1"
                     /translation="MLDSKEELKESENDAPKLETPLREEPRLAPQTLPEASEVLENKR
                     EESKVEITEPAQADDIRKVVGELAKDISITKLYMTGHSLGGYLAQIAAVEDYQKYPDF
                     YNHVLRKVTTFSAPKVITSRTVWDAKNGF"
     gene            11390..11965
                     /locus_tag="AC0DU4_001424"
     CDS             11390..11965
                     /locus_tag="AC0DU4_001424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000445853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="discoidin domain-containing protein"
                     /protein_id="HIN4237373.1"
                     /translation="MESRKLAVSGKIKHYVVDNDNVVTPLIHNNRDIVTFTGNSRFKH
                     RSRGYFESPMNDIPNFNIGKQATLDKHGYRDPKLDKVRFFKKQALPQSSSQPSAEPME
                     NIALGKQVTQSSTAFGGDARRAVDGKVDGNYGHNSVTHTNFQSKPWWQVDLAKEETIR
                     QINIYNRTDTAQDRLANFDVILLDSSGKEIE"
     gene            11990..12501
                     /locus_tag="AC0DU4_001425"
                     /pseudo
     CDS             11990..12501
                     /locus_tag="AC0DU4_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001275913.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-activated cytolysin C-terminal
                     domain-containing protein"
     gene            13159..13869
                     /gene="deoD"
                     /locus_tag="AC0DU4_001426"
     CDS             13159..13869
                     /gene="deoD"
                     /locus_tag="AC0DU4_001426"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004731 - purine-nucleoside phosphorylase
                     activity [Evidence IEA];
                     GO_process: GO:0006139 - nucleobase-containing compound
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HIN4237374.1"
                     /translation="MSIHIAAQQGEIADKILLPGDPLRAKFIAENFLGDAVCFNEVRN
                     MFGYTGTYKGHRVSVMGTGMGMPSISIYARELIVDYGVKKLIRVGTAGSLNEEVHVRE
                     LVLAQAAATNSNIVRNDWPQYDFPQIASFDLLDKAYHIAKELGMTTHVGNVLSSDVFY
                     SNYFEKNIELGKWGVKAVEMEAAALYYLAAQYHVDALAIMTISDSLVNPDEDTTAEER
                     QNTFTDMMKVGLETLIAE"
     gene            complement(13892..>14157)
                     /locus_tag="AC0DU4_001427"
     CDS             complement(13892..>14157)
                     /locus_tag="AC0DU4_001427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="DNA topology modulation protein"
                     /protein_id="HIN4237375.1"
                     /translation="DLPTTNIIEPFKRYLKYRGKVRESMAADCPERFDWEFIRWILWD
                     GRSKTQKENYQKLCQEYSHKVTILRNQRELDQFLDKKRKSYNS"
BASE COUNT         4184 a         2595 c         3182 g         4196 t
ORIGIN      
        1 aaagtatctg gaagaagata tcagaggatt tctttggttg caggtctaac aaatggtgag
       61 ttaatcgctc caatgactta cgaagagatg atgacgagcg acttttttga agcttggttt
      121 cagaagtttt tcttaccaac attaaccaca ccatcggtta ttattatgga taatgtaaga
      181 ttccatagaa tggggaagaa tgtaagattc catagaatgg ggaagctaga acttttatgc
      241 gaagagtttg ggcataaact tttacctctt cctccctact cgcctgagta caatcctatt
      301 gagaaaacat gggctcatat caaaaagcac ctcaaaaagg tattaccaag ttgcaatacc
      361 ttttacgagg ctcttttgtc ctgttcttgt ttcaattgac tatagcagat tgaaatgaga
      421 acaaatcgat tgggaaagta aaattaattt ctataaatgt tttagcaatt gtttcgtact
      481 atttcagatt cagtctacta tatatcataa tggacaaagg gcaagctgtc aagaaattac
      541 agttatttta gtaaaaaaag aagcagaaaa atttcatttt ctactccttt tctataggat
      601 ttatttttct ttttcagaac ttttaacttc agcttttttg gcagatttaa tctgaatgtt
      661 tcccttgcta gtcataactg ctttgagatc tttttcgctt ggattttcaa ggtagtagtc
      721 agtgattgtg tcctcaatat agtcttgaat agtccgacga agtgggcgtg ctcccatttt
      781 tggatcataa cctaggtcaa ccaacttttc cttgacctta tcagttacat ccaaacgaat
      841 gttgttgcta gagaggcgct tgttaacatc tgctagcatg agctcgacaa tctgaaggag
      901 gttatccttg ctgagagcct taaattcgat aatgccatca aaacggttca taaactctgg
      961 gctaaagaag ttaccgagtt caccgaggac agaattggta cgtccttctc tagcagcacc
     1021 aaatccaacg ctagcttcgg tctttcctgt acctgcattt gaggtcatga taatgatggc
     1081 atccttgaag ctaacggtgc gtccttgccc gtctgtcaaa cgaccatcgt ccaagacttg
     1141 aagaaacatg tgcataacat ctgggtgagc tttttccact tcatcgagaa ggatgagaga
     1201 atatggattg tggcgaactt tttcagttaa ttgaccagcc tcatcatagc caacataacc
     1261 tggaggggcg ccgaccaact tagccacact atgtttttcc atgtattcac tcatatcaaa
     1321 gcgaatcata ctatcagcag aaccaaaaag ttcgatagcc agttgtttgg aaagttctgt
     1381 cttaccgaca ccagttggcc caacgaagag gaagcttccg attgggcggt taggggtacc
     1441 aagtccgaca cgattacggc gaatagcctt ggcaatctta tcgactgcat catcttggcc
     1501 aataacatga gacttgagat cttcggctag atggatgagt tgagattgtt ctttctcttt
     1561 caaatcacca acagggatat tggttttctg ctcgataatg tgctcaatag ttttctcgct
     1621 gatgatagga gtatcctggt ctgtgatctt tttcttttgc atttccttat acttggcaat
     1681 ctggtcgcgg aagtaggccg ccttctcaaa atcttcttct cgtgtagctt gagacttgag
     1741 attttcagcc tcaatcaagc gctgatcaat tactttagga tccacaaaat tcaaggtcaa
     1801 gttcatctta gaaccagctt catctaggag gtcaatggcc ttgtcaggca agaagcgatc
     1861 ttggatgtag cgattggaaa gagttgcagc tgcttcaatc gcagcatcgg tatattgaac
     1921 gtggtggtaa tcttcgtatt tcttttgaat ccctttgaga atagtgattg tttcgtccac
     1981 cgttggttca tcgactttaa caggctgcat acgacgctcg agggcagcat ccttttcaat
     2041 gatacggtat tcattgaggg tagtagcacc gactagttgc agttctccac gagcaagggc
     2101 tggcttgagg atatttcctg cgtccatatt accatcactc gcagaaccag caccaacaat
     2161 ttcatggatt tcatcgataa agaggatgat gtcttcacgt ttgcgaattt cttccatgag
     2221 tttttgcatg cgttcttcaa attgtcctcg aatccccgtt ccttgaacta agctaaccac
     2281 atccagacgg atgacttgtt taccttggag tttatgtggc acatcgccat cgacaatttt
     2341 ctgagctaga ccttcgacaa cggccgtttt tccgacacca ggttcaccga taaggacagg
     2401 attattcttg gttctacgat tgagaatctc gatgacacgg ataatctcat cgtcgcgccc
     2461 aataacgggg tcaatgtctc cacgacgggc aatttcagtt acattaatac caaattcttc
     2521 cagcaggcct ttttcttggc taggtggcgg agtttgagca gatccacgat tttgggaacc
     2581 ataaccgccg tttccaccgt aacctccacc tgattgggtt gggggaatag gaggagtatt
     2641 gctagaaggt ctgaaattgt ttagatcatt gaagaaatca ccaaagggat cgaagtcacg
     2701 attgttcaga tccgtcatac ctttgaagag gctattgtta ggatctgttt tgataatctt
     2761 atagcagttt tgacagaggt caatttgttt ttgttttcca ttgagattgg tgtaaagatg
     2821 aattgttgag tcgttaattt tacagttttg acaaagcata catctacctc atttctttct
     2881 ttagcctgac ttgtttaaag gtcaaaaata gtcaaattct atactctcat tataacagga
     2941 ttggggtgta aagcaagtaa aaagattgaa gctttgagaa gttgttacaa tgaaaatttt
     3001 tgtgaatttg gactataaaa aaatcctatt tgtgagacaa aaaggatttt acttagacat
     3061 gcagggacaa tcccagcttg ttttagatta gtagagaagt tcgtaaattt ccattgcgat
     3121 taagtcaatg ctatcaaacg tatacgtttc gcgatcttct acgtcacgaa gggtaaagat
     3181 tgggccgttt tcttcgtcgt ggctgtacgc aacttctgca acaacaactc cttcgcgttc
     3241 aaaattacgt tttaaatttc cgccatcgtt tgccattgct tcaaggcggt tgatgattct
     3301 aaccaaatgt gattccattt tgattctcct tcatttctta tcgttactat tttaccataa
     3361 aggaggccaa cttgactaga aaaaactaag atttctcact aattctgcta gtttaaagat
     3421 ttttaaataa attggataaa agatttaaat tttaattcaa aacatgttat aatcatacag
     3481 tattctattt tagaaagcag tgtgactatg aatttttctt ttttacctaa gtatttacct
     3541 tattttaact atggggctgt tgtgacgatt cttatttcta tctgtgttat ctttttggga
     3601 actattttgg gtgttgtctt ggcttttggg caacgttcaa agtttaaacc gcttgtttgg
     3661 ttggccaact tgtacgtttg gattttccgt gggacaccga tgatggttca aattatgatt
     3721 gcctttgctc ttatgcatat caatgctccg actattcaga ttggaatttt aggtgttgat
     3781 ttttcgcgtc tgattccagg gattttgatt atctctatga atagtggtgc ttatgtttcg
     3841 gagactgttc gtgccggaat caatgcggtt ccaaaaggtc agctagaggc ggcttattcg
     3901 ctagggattc gtcctaaaaa tgcgatgcgt tatgtgattt tgccacaagc agtcaaaaat
     3961 atcttgccag cattggggaa cgaatttatc accattatca aggacagctc cctcttatca
     4021 gctattgggg tcatggagtt gtggaatggg gctacaacag tttctacaac aacctatcta
     4081 cctttaacac cacttttatt tgcagcattt tactacttga ttatgacctc tattctgaca
     4141 gtagccttga aagcttttga aaaacatatg ggacaaggag ataagaaata atgacagaaa
     4201 ccttgataaa aattgaaaat ttacataaat cttttggaaa gaatgaagta ttgaagggca
     4261 tcaacctcga gattaaaaga ggagaagttg tcgttatcat cggtccttca gggagtggga
     4321 aatctacctt gcttcgctct atgaatttgt tggaggaagc aaccaagggg aagcttatct
     4381 ttgagggagt cgatattacg gacaagaaga atgacctgtt tgccatgcgt gagaagatgg
     4441 gcatggtttt ccaacaattt aacctctttc ctaatatgac tgtgatggaa aatattacct
     4501 tgtcacctat caagactaaa ggtgaaagca gggaagttgc tgagaagaga gcccaagagc
     4561 ttttggaaaa agttggtttg ccagataagg cagacgctta tccacagagt ctgtcgggtg
     4621 ggcaacaaca acggattgcc atcgcgcgtg ggttggctat ggaaccagat gttttgctct
     4681 ttgacgaacc aacttcagcc ttggatcctg aaatggtagg tgaggtattg gctgttatgc
     4741 aagaccttgc caagtcaggg atgactatgg ttatcgtaac acatgagatg ggatttgccc
     4801 gtgaggtggc agatcgtgtt atctttatgg cagacggtgt ggttgttgaa gatgggacac
     4861 ctgagcagat ttttgaacaa acccaagaac aacggactaa agatttcttg agtaaggttt
     4921 tataatctat tttaaaattt caagacaaga ttagtgaaaa gttcaaccag agctttttct
     4981 tatagtttga aactatagga taacctagga aagaagtgtt agagggcact agcagttttt
     5041 ggtataatgg aagatatttg aaagaaaaga gaagtgatat gacacagatt attgatggga
     5101 aagctttagc ggccaaattg caggggcagt tggctgaaaa gactgcaaaa ttaaaggaag
     5161 aaacaggtct agtgcctggt ttggtagtga ttttggttgg ggataatcca gccagccaag
     5221 tctacgttcg caacaaggag aggtcagctc ttgcggctgg ttcccgtagc gaagtagtgc
     5281 gagttccaga gaccattact caagaggaat tgttagacct gattgctaaa tataatcagg
     5341 atccagcttg gcatgggatt ttggtccagt tgccattacc aaaacatatc gatgaagagg
     5401 cggttttatt agccatggat ccagaaaagg atgtggatgg tttccatccc ctaaacatgg
     5461 gacgtctttg gtctggacat ccagtcatga ttccctcgac acctgcagga attatggaaa
     5521 tgtttcatga atatgggatt gacttggaag gtaaaaatgc ggtcgtcatc ggtcgttcaa
     5581 atatcgttgg aaaacctatg gctcagcttc ttttggctaa aaatgcgaca gtaaccttgg
     5641 cccactcacg aactcataat cttgccaagg tggctgctaa agcagatatt cttgtagtcg
     5701 caatcggccg cgccaagttt gtgactgctg actttgtcaa accaggtgcg gttgtcattg
     5761 acgttgggat gaatcgagat gaaaatggga agctctgtgg agatgttgat tatgaggcag
     5821 ttgcaccact tgctagccat atcacgccag tccctggagg tgtcggtcct atgaccatta
     5881 ccatgctgat ggagcaaact tatcaagcag cacttcggac attggataga aaataagaga
     5941 aacattcgat taatagagtg tattttctat agctatatct aaaatggcag aaatgaatat
     6001 taaattttag atataagatt acaaaaggag gtctgcgtct cctttttatt gtataataaa
     6061 agtgagagga aaaaaggatg aaagtgatta atcaaacctt attagaaaaa gttattattg
     6121 aacgttctcg ttcaagtcat aaaggagatt atggtcgtct gctgctgctt ggtggtactt
     6181 atccttatgg aggtgccatc atcatggctg ctttagcagc tgtaaaaagc ggtgcaggat
     6241 tggtgaccgt tggaacggac agggaaaata tcccggctct gcacagccat ttacctgagc
     6301 ctatggcctt ttctcttcaa gaccagcaat tgttaaaaga gcaattggag aaggcagaag
     6361 ttgtcttgct ggggcctggt ttacgagacg atgcttctgg agaaaatcta gtaaaacagg
     6421 tctttgttaa tttaagccaa aatcagattt tgattgtaga cggaggtgcc ttgaccattc
     6481 ttgctaggac aagtttgtca tttccctcaa gccagcttat cctaactcct caccaaaaag
     6541 aatgggaaaa attatctgga attacgattg aaaagcaaaa ggaagatgca acggctagtg
     6601 ttctgacttc cttccctcaa ggaacaattt tggtggagaa aggcccagct actcgtattt
     6661 gggaagttgg ccaatctgat tattaccagt tacaggttgg tggtccttat caggcgactg
     6721 ggggaatggg agatactctg gctgggatga tcgcaggatt tgtaggccaa ttccgacagg
     6781 ccagtctcta cgagcgtgtg gcagtagcga cccatcttca ttcagccata gcccaagaac
     6841 tatctcaaga aaattatgtg gtcttaccga cggaaatcag caggtatctt cccaaaataa
     6901 tgaaaattat ttgtcaacaa gagagggtaa gtaaagataa acttgtttaa aatagacaga
     6961 taaatctact tccttctctt aatttatgat tcttgaaatg cgcctgcttt aaggctaaac
     7021 tagacgtatc aaagttaaga ttttgttttt gtaactggaa agagatgaac aaatcaaata
     7081 cataaaagat aaactcattt ttattcgttt ggtaaaaata aaatgcatat ttttaaagaa
     7141 agattgatga aaaatgtaga tttgatgttt ttacttgaat aaaaagcggt ttcatagtaa
     7201 aataagaact gagaatgatg gaggtaaatc ggtggaaaat ctgaagaaaa tggcaggtat
     7261 caaggctgct gagttcgtga gcgatggaat ggtcgttgga cttggaacag gctcgactgc
     7321 ctattatttt gtcgaagaaa tcggtcgtcg tatcaaggaa gaaggattgc agattacagc
     7381 tgtaacaact tctagtgtga ccactaaaca ggcagaaggc cttaatatcc cgctcaagtc
     7441 tattgaccaa gtagactttg tcgatgtgac ggttgatggc gcggatgaag tggatagtca
     7501 gtttaatgga atcaaaggcg gtggtggtgc ccttctcatg gaaaaggtgg tcgcaacacc
     7561 atcaaaagaa tacatttggg tggtggatga aagcaagctg gtcgaaaaac taggtgcttt
     7621 taaattgcca gtagaagtgg ttcagtatgg tgcagagcag gtctttcgtc attttgaacg
     7681 agctggctac aaaccaagtt tccgtgaaaa agacggccaa cgttttgtga cggatatgca
     7741 gaattttatc attgacctcg ccttggatgt cattgaaaat ccaattgctt ttggacaaga
     7801 attggaccat gtcgttggtg ttgtggagca tggtttattc aaccaaatgg tggataaggt
     7861 aatcgttgct ggacgagatg gagttcagat ttcaacttca aaaaaaggaa aatagaaggg
     7921 ggcataagat gtctaaattt aatcgtattc atttggtggt actggattct gtaggaatcg
     7981 gtgcagcacc agatgctaat aactttgtca atgcaggggt tccagatgga gcttctgaca
     8041 cactgggaca catttcaaaa acagttggtt tgaatgtccc aaacatggct aaaataggtc
     8101 ttggaaatat tcctcgtgaa actcctctta agactgtagc agctgaaagc aatccaactg
     8161 gatatgcaac aaaattagag gaagtatctc ttggtaagga tactatgact ggacactggg
     8221 aaatcatggg actcaacatt actgagcctt tcgatacttt ctggaacgga ttcccagaag
     8281 aaatcctgac aaaaatcgaa gaattctcag gacgcaaggt tattcgtgaa gccaacaaac
     8341 cttattcagg aacggctgtt atcgatgatt ttggaccacg tcagatggaa actggagagt
     8401 tgattatcta tacttcagct gaccctgttt tgcagattgc tgcccacgaa gacattattc
     8461 ctttggatga attgtaccgt atctgtgaat acgctcgttc gattaccctt gagcgtcctg
     8521 cccttcttgg tcgcatcatt gctcgccctt atgtaggtga accaggtaac ttcactcgta
     8581 cggcaaaccg tcgtgacttg gctgtatctc cattttcccc aactgttttg gataaattga
     8641 atgaggctgg tatcgatact tatgctgtgg gtaaaatcaa cgatatcttt aacggtgctg
     8701 gtatcaacca tgacatgggt cacaacaagt caaatagtca tggaattgat acactattga
     8761 agactatggg acttgctgag tttgaaaaag gattctcatt cacaaaccta gttgactttg
     8821 atgcccttta cggccatcgt cgtaatgctc acggttaccg tgattgcttg catgagtttg
     8881 atgaacgctt acctgaaatt atcgcagcta tgagagagaa tgaccttctc ttgattactg
     8941 cggaccatgg aaatgaccca acgtatgcag gaacggatca cactcgggaa tatattccat
     9001 tgttggccta tagccctgcc tttaaaggaa atggtctcat tccagtagga cattttgcag
     9061 atatttcagc gactgttgcc gataactttg gtgtggaaac tgctatgatt ggggaaagtt
     9121 tcttagataa attggtataa gatgacgcgc tattctttgc tggtgagagg tatcaatgtt
     9181 ggtggtaaga ataaggtcgt catggcggag cttcgtcaag aattgacaaa cttgggactg
     9241 gaaaaggttg agagctacat caacagtggc aatattttct ttacttcgat agattccaaa
     9301 gcccaattgg ttgaaaagct agagactttc tttgcagtcc attatccatt tattcagagc
     9361 ttttctttac tgagcctaga ggactttgag gcggaacttg aaaatctacc agcttggtgg
     9421 agcagagact tggcacgaaa agattttctc ttttacactg agggtttgga tgtggaccaa
     9481 gtcatcgcga cagttgaaag tttagagctg aaagatgaag tgctttattt tggaaaactt
     9541 gggattttct gggggaaatt ttctgaagaa tcctattcta agactgccta tcataagtac
     9601 ttgctgaagg tgcctttcta ccgccacatt actattcgta atgctaaaac ctttgacaaa
     9661 attggtcaaa tgctaaaaaa ataataaagg agacacacaa tgacattttt aaacaaaatc
     9721 catgaaactg ctactttcct gaaagaaaag ggaattgcag cccctgagtt cggtctaatc
     9781 cttggatcag gacttggaga attggcagaa gaaatcgaaa atccagttgt agtagactat
     9841 gctgagattc caaactgggg ccgttcaaca gtagtcggtc atgctggtaa attggtatat
     9901 ggtgaactgg caggtcgcaa ggtcttggct cttcaagggc gtttccattt ctatgaaggg
     9961 aatcctctgg aagtggtgac tttcccagtt cgtgtgatga aagttcttgg atgtgaaggt
    10021 gttattgtaa ccaatgcagc tggcggtatc ggatttggtc ctggtacctt gatggctatc
    10081 tcagaccata tcaacatgac ggggcaaaat ccattgatgg gtgaaaactt ggatgacttt
    10141 ggcccacgtt tcccagatat gtctagggct tacacaccag aataccgtgc cactgcccat
    10201 gaagtggcta aaaaacttaa tatcaagctt gatgaaggtg tctatatcgg agttactggt
    10261 ccgacttatg aaacaccagc agaaattcgt tcctataaga cactgggagc agatgcagtt
    10321 ggtatgtcta cggttcctga agttatcgtg gcagcccact ctggcttgaa agttctggga
    10381 atttcatgta tcactaactt tgcggccggt ttccaagaag aactcaatca cgaagaagtt
    10441 gtagaagtga ctgaacgtgt taaaggtggt ttcaaaggct tgcttaaagc gattcttgct
    10501 gaattgtaag aaaaaagatt taaaaggggg agtgcctctg tcttttcagg attgactgcc
    10561 tatccgtatt aaagaagaaa cagaggaata ctatgagctt cttcctgctc ttataactga
    10621 aagaagcgga agaataggta tgtctgatct gatagccagc attgtgaaag acaagattct
    10681 aggatactag cattagcttc ctagccaagc agactagtat gataaggaga gatgagaatg
    10741 aattgacttt ctgaatttct cagtcttatc atatatagca caatgagatt tcgcttgagt
    10801 ctgcttgtaa ataaacgaaa agaaagataa gaaataatga aaattggtca acgaattatg
    10861 cgctttggca taaaaaatta agtatcggag ttgtatctgt tgtagtcggc tttgatttct
    10921 agctccagct ggaatttcag ccaatgaagt aaagcaagat gtaacatctg aagtggtaat
    10981 aggtgtgcta gattctaagg aggaattgaa agagtcagaa aatgatgctc caaaactaga
    11041 aactcctctt agagaggagc caagactagc tcctcaaacg cttccggaag caagtgaagt
    11101 tcttgaaaac aaaagggaag agtcaaaagt agagataaca gagccagctc aagcggatga
    11161 tatccgcaag gttgttgggg aattagccaa ggatataagt attactaagt tgtatatgac
    11221 aggtcattct cttggaggct acctagctca gattgcagcg gttgaagatt accaaaaata
    11281 tcctgatttt tataaccatg tattgaggaa agtgacaact ttcagtgctc ctaaagtgat
    11341 tacttccaga actgtttggg atgctaagaa tggtttctga gatgttggtt tggaaagtcg
    11401 taaattagct gttagtggaa aaattaagca ttatgtggtt gataatgaca atgttgtgac
    11461 tcccttgatt cataataatc gtgatattgt tacatttaca ggtaattcac gctttaaaca
    11521 ccgttctcgt ggctattttg aaagtccaat gaatgatatt cctaacttta atattggtaa
    11581 acaagctacc ttggataaac atggttatcg tgatccgaaa ttggataaag tgcgattctt
    11641 taagaaacag gctctacctc aatcttctag tcaaccaagc gctgaaccaa tggaaaatat
    11701 tgccttagga aaacaggtta ctcaaagttc gacagctttc ggaggagatg ctagaagagc
    11761 tgtggatggc aaagtcgatg gtaactatgg tcacaattct gtcactcata caaacttcca
    11821 atctaagcct tggtggcaag tagatttggc taaagaagaa accattcgcc aaatcaatat
    11881 ttacaaccga acagacactg cccaggatag attggcaaac tttgatgtca ttcttttaga
    11941 cagttctggt aaagaaattg agtgaaaacg tataatatct cctaaagatg tgtcagcaca
    12001 aattacgatt aaccataaaa aacgcgctat gttcggattg agctagaagg ctataatgcc
    12061 ctcagtcttg cagaagttga agttttccgc tttatagcta cgaatgctga aacggcgaca
    12121 caagtttcta agccagttca accaatcagt cagactcctg tgaaagataa aacattgaca
    12181 attcaacaca gtggagctta cattgcccgc tactccataa cttgggaaga agttccagta
    12241 gataaagatg gaaaccaagt tgttcgtagt cattcttggg aaggaaacgg ttgcaaccag
    12301 actgcaggtt ttgtcctcaa cctcccaatc aaagaaaata tgagaaatct gcgagttaag
    12361 attgagaaaa agacgggcct actatggaat agatggcaaa caatctatga aaacagacca
    12421 attttagctc aaccccaccg taaaattacc cattggggta cgacattgaa ttccaaggtg
    12481 agtgacgatg atgtcttgta atctgatggt acaatgacag ttagtttgtc tagtttataa
    12541 gaaagtacta cctgagcttg aatagaactc aggtagctct ctgtgaaaga acaaaattaa
    12601 tactcaatga aaatcaaaga gcaaactagg aaactagccg caggttgctc aaagcactgc
    12661 tttgaggttg tagataagac tgacgaagtc agtcacatat ataatccaag gcgacgttga
    12721 cgtggtttga agagattttc gaagagtata aacagaaagg tagagcgcgt gttctaattt
    12781 gaacacgagt agaaaacttt tctaaaaaca aaaacgaaag gatgggtaaa ctgtattcgc
    12841 tgaactgaat acgggcgact ctcctctaaa tcaaaattaa gaaagaaagg aattgacccc
    12901 accctaaaag cagtgggaaa aagatagttg gtctagcgag catcgctcac tgcgcccaac
    12961 tcctattttc ccttcgcttt ttgacgggtt tggtatcttt ctcaatataa aatataaaat
    13021 aaagaaaggt agagcgtgtg ttttgatttg aacacgagcg gaaaactcgg aaaatagata
    13081 atctgactga aaaatcagga tttctcgtcg gcttcctaat tttcagtcgt tttcttctcg
    13141 ctctttgtat cataaattat gtctatccat attgctgctc agcagggtga aattgctgat
    13201 aaaattcttc ttcctgggga tcctcttcgt gctaagttta ttgcggagaa tttccttggt
    13261 gatgctgttt gttttaacga agtgcgtaac atgtttggtt acactggtac ttacaagggt
    13321 caccgtgtat ctgtcatggg aactgggatg ggaatgccat ctatttcgat ttatgcgcgt
    13381 gagttaatcg tagactacgg tgtgaagaaa ttgattcgtg tgggaactgc aggttctttg
    13441 aatgaagagg ttcatgttcg tgaattagtt ttggcgcagg cggctgcaac caactcaaac
    13501 atcgttcgta atgactggcc acagtacgat tttccacaaa ttgctagctt tgatttgctt
    13561 gataaagcct accatatcgc caaagaactt ggtatgacta ctcacgttgg gaacgttttg
    13621 tcatctgatg tcttttactc aaattacttt gaaaagaata tcgagcttgg taaatgggga
    13681 gtcaaggctg tggaaatgga agcagcagct ctttactatc ttgctgccca ataccatgtt
    13741 gatgcgctag ctatcatgac catctctgat agcttggtca atccagacga agacacaact
    13801 gcagaagaac gtcaaaatac cttcactgat atgatgaagg ttggtttgga aaccttgatt
    13861 gcagaataat tatagccaaa aaggaagccc tttatgaatt gtaggacttc cttttcttat
    13921 ccagaaattg atctagctct ctctgatttc gaagaatagt gactttatgt gaatattctt
    13981 ggcaaagttt ttggtaattt tctttttgag ttttgctacg tccatcccaa agaatccatc
    14041 tgataaactc ccagtcaaag cgttcagggc aatctgccgc catgctttct ctgacttttc
    14101 cacggtattt aagataacgc ttaaagggct ctataatatt tgtagtgggt aaatcca
//
LOCUS       DBMVGT010000043        13525 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.043, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000043 DBMVGT010000000
VERSION     DBMVGT010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 13525)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13525)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13525
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.043"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..540
                     /locus_tag="AC0DU4_001428"
     CDS             <1..540
                     /locus_tag="AC0DU4_001428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000067848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase-like TK C-terminal-containing
                     protein"
                     /protein_id="HIN4237376.1"
                     /translation="RAMPNLNVFRPADARETQAAWYLAVTSEKTPTALVLTRQNLTVE
                     DGTDFDKVAKGAYVVYENAADFDTILIATGSEVNLAVSAAKELASQGEKIRVVSMPST
                     DVFDKQDAAYKEEILPNAVRRRVAVEMGASQNWYKYVGLDGAVLGINTFGASAPAPKV
                     LAEYGFTVENLVKIVRNLK"
     gene            657..956
                     /gene="yajC"
                     /locus_tag="AC0DU4_001429"
     CDS             657..956
                     /gene="yajC"
                     /locus_tag="AC0DU4_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HIN4237377.1"
                     /translation="MNPNITFLIMLVGMMALMFFMQRSQKKQAQKRMESLNKLQKGYE
                     VITIGGLYGTVDEVDTEKGTIVLDVDGVYLTFELAAIKTVLPLKETASLEGAIEK"
     gene            1003..1431
                     /locus_tag="AC0DU4_001430"
     CDS             1003..1431
                     /locus_tag="AC0DU4_001430"
                     /EC_number="3.1.3.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA];
                     GO_process: GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight
                     protein-tyrosine-phosphatase"
                     /protein_id="HIN4237378.1"
                     /translation="MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNP
                     IHKGTQGIFQEYEIPYDKNKTSLQISKEDFEAFDYIIGMDASNISDLRQMCPVDCQDK
                     IYSFSSESVPDPWYTGDFEETYRRVQEGCQAWLERLEKES"
     gene            1433..1843
                     /locus_tag="AC0DU4_001431"
     CDS             1433..1843
                     /locus_tag="AC0DU4_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000427064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MORN repeat-containing protein"
                     /protein_id="HIN4237379.1"
                     /translation="MENLTNFYEKYRVYLTRPRLELLAVVTIVFCAVLVFFLNIPGKG
                     VLKLDNGTIVYDGSLVRGKMNGQGTITFQNGDQYTGGFNNGAFNGKGTFQSKEGWTYE
                     GDFVNGQAEGKGKLTTEQEVVYEGTFKQGVFQQK"
     gene            2143..4794
                     /gene="adhE"
                     /locus_tag="AC0DU4_001432"
                     /gene_synonym="adhC"
     CDS             2143..4794
                     /gene="adhE"
                     /locus_tag="AC0DU4_001432"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA];
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006066 - alcohol metabolic process
                     [Evidence IEA];
                     GO_process: GO:0015976 - carbon utilization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HIN4237380.1"
                     /translation="MADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDY
                     IVAKASVAALDAHGELALHAFEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEE
                     DDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSVHA
                     ARIVRDAAIAAGAPENCVQWITEPSMEATSALMNHEGIATILATGGNAMVKAAYSCGK
                     PALGVGAGNVPAYVEKSANIRQAAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAE
                     FKSYHTYFVNKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKPATWIAEQAGFTVPE
                     GTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIH
                     TADEELTKEFGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVS
                     AINLLNIKKVGRRRNNMQWMKLPSKTYFERDSIQYLQKCRDVERVMIVTDHAMVELGF
                     LDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFRPDTIIALGGGSPMDA
                     AKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFA
                     VISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMA
                     SDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNASTIAGMAFANAFLGISHSMAH
                     KIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPA
                     STPEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRELAFLAYEDQCSPANP
                     RLPMVDHMQEIIEDAYYGYKERPGRRK"
     gene            complement(5780..6088)
                     /locus_tag="AC0DU4_001433"
     CDS             complement(5780..6088)
                     /locus_tag="AC0DU4_001433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000134125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HIN4237381.1"
                     /translation="MTEEMEYICFQLIANSGAAKSSFIEAIQLAKAGNLKEAKIKVEE
                     AEDSLVEAHKIHSNLIQKEATGEKIGFSLLFMHAEDQMASTEIIQLLSKEFIDLYQNK
                     "
     gene            complement(6085..6393)
                     /locus_tag="AC0DU4_001434"
     CDS             complement(6085..6393)
                     /locus_tag="AC0DU4_001434"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4237382.1"
                     /translation="MKQILLVCNAGMSTSMLVKKMQQSATERGIEISIQAKSMTEAKK
                     NIHEADVILIGPQIRYELLAVKEIAGNIPVDTIDMRDYGMMNGAKVLEQALAWIGEIR
                     "
     gene            complement(6398..7693)
                     /locus_tag="AC0DU4_001435"
     CDS             complement(6398..7693)
                     /locus_tag="AC0DU4_001435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000798148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HIN4237383.1"
                     /translation="MKNSKFIDQFATFAGKLGNQIHLKTLRDAFVTVMPLYILAGLIV
                     LLNNTVFKWIFQGDTLTKFQYWGITIANGTLSISGMIIAVMVGYFLAKNRDFENPLAA
                     SMLSLVSLIVMMPNTVSVVPDGAKDAVNISGVLSFNNTGTGAMFAGVIVAIIATELFI
                     ELSNVKALQMNLGENIPPAVSRSFSVLLPVMTVISLFGVVSALLFNITGMNLISIITI
                     FIQEPIRHIGTSLIGVIIIYSLGNMLWLFGIHQAVIYSAILEPLLLINITENITAANN
                     GQAIPHIINLSQIQTFALMGGSGSTLCLLIATFLVSRNAVSKNVAKLSFGPGIFNINE
                     PVLFGYPIVYNISLAIPFITVPVLGILISYLATVTGFMSPAFIQVPWTTPVFLNAWLA
                     TAGDVRAVLVQFIIFALGVLLYIPFIKVNDKVVEQEMEG"
     gene            complement(7711..9120)
                     /locus_tag="AC0DU4_001436"
     CDS             complement(7711..9120)
                     /locus_tag="AC0DU4_001436"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HIN4237384.1"
                     /translation="MKKKLVFPNLFWWGAASSGPQTEGQYGKVHENVMDYWFKTHPED
                     FFDNVGPLVASNFFHTYTEDFHLMKEIGVNSFRTSIQWSRLIKNLETGEPDPKGIAFY
                     NAIIEEAKKNQMDLVMNLHHFDLPVELLQKYGGWESKHVVELFVKFAKTAFTCFGDKV
                     HYWTTFNEPMVIPEAGYLYAFHYPNLKGKGKEAVQVIYNLNLASAKVIQLYRSLGLDG
                     KIGIILNLTPAYPRSNSPEDLEASRFTEDFFNKVFLNPAVKGTFPERLVKQLERDGVL
                     WSHTEKELQLMKSNTVDFLGVNYYHPKRVQAQANPEEYQTPWMPDQYFKEYEWPERRM
                     NPYRGWEIFPKAIYDIAMIVKEEYDNIPWFISENGMGVENEARFIDENGVIDDVYRIE
                     FYEEHLRWLHKAIEEGSHCFGYHAWTAFDCWSWNNAYKNRYGFISVDLETQKRTIKSS
                     GRWYRKVSDNNGFEVEIEE"
     gene            9278..10006
                     /locus_tag="AC0DU4_001437"
     CDS             9278..10006
                     /locus_tag="AC0DU4_001437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HIN4237385.1"
                     /translation="MSTKYLFIYNEIREKILCNKYTMNEQLPDEMTLAKQFACSRMTI
                     KKALDLLVSEGLIFRKRGQGTFVLSRGSSKRKLIVPERDIRGLTKISEDAHSTIDSRI
                     IHFKLEFANEFLAEKLQVALQSPVYNIYRLRIIDGKPYVLEQTYMSTDVIPGITEDIL
                     QKSIYNYIEGKLGLHIASATKILRASSSSENEQHYLQLLPTEPVFEVEQVAYLDNGTP
                     FEYSISRHRYDLFEFNSFALRHSS"
     gene            10465..10659
                     /locus_tag="AC0DU4_001438"
     CDS             10465..10659
                     /locus_tag="AC0DU4_001438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HIN4237386.1"
                     /translation="MKGKEYENRTVSFAISSKGEKMKVENISYRVDHRILFDNISFDT
                     SSSGVTLITGKNGTGKSTLL"
     gene            complement(10757..10885)
                     /locus_tag="AC0DU4_001439"
     CDS             complement(10757..10885)
                     /locus_tag="AC0DU4_001439"
                     /inference="COORDINATES: protein motif:HMM:NF013677.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237387.1"
                     /translation="MISSTLKIHPNSLYRWIQEYEKYEESAFPGHGSALRHTQFEM"
     gene            complement(11025..12335)
                     /locus_tag="AC0DU4_001440"
     CDS             complement(11025..12335)
                     /locus_tag="AC0DU4_001440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HIN4237388.1"
                     /translation="MIHLIMISAIALAIGIGYRTKINIGLLAIAFSYLIATTLMGLSP
                     KELLHFWPTSLFFTIFSVSLFYNFAITNGTLDVLAQHILYRTRTYPNALYMILYLMAT
                     LLSALGAGFFTTMAVCCPLAITLCQKADKHPLIGAQAVNWGASGGANLITSSSGIVFQ
                     GLFKQMGWEEQAFSLGNHIFIVSIIYPLIVLLLLSCYSHYSKGKTNSSLTIDQPPLLS
                     KVQRQTTLLMISSMVLVWLFPLLHLIFPNIAWIATYQKTFDIGFVSILMVCLALRLKL
                     GKQEAILAKVPWATIIMLCGMSLLMSLAVKSGLVTLIGHLMTTSIPHFWLPLFFCVIA
                     GVMSLFSSTLSVVAPALFPIIAIISAQNPQIDIHLLTTATVIGALSTNISPFSSAGSL
                     IQLSLPNIEERGLAFKKQIILGVPISLSLGLLTTWILILLASLS"
     gene            12572..13444
                     /gene="nadC"
                     /locus_tag="AC0DU4_001441"
     CDS             12572..13444
                     /gene="nadC"
                     /locus_tag="AC0DU4_001441"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004514 - nicotinate-nucleotide
                     diphosphorylase (carboxylating) activity [Evidence IEA];
                     GO_process: GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HIN4237389.1"
                     /translation="MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV
                     SLFAKEAGVLAGLTVFKRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL
                     TCERVALNFLQHLSGIASMTAAYVEALDDDCIKVFDTRKTTPNLRLFEKYAVRVGGGY
                     NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGA
                     DIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK
                     SLDFSMKGLTYLDV"
BASE COUNT         4291 a         2447 c         2649 g         4138 t
ORIGIN      
        1 cgtgctatgc caaatctaaa tgttttccgt ccagcagatg cgcgtgaaac gcaagcagct
       61 tggtaccttg cagtgacaag tgagaaaaca ccaactgccc ttgtcttgac acgtcaaaac
      121 ttgactgttg aagatggaac agacttcgac aaggttgcta aaggtgctta tgttgtatat
      181 gaaaatgcag ccgactttga taccatcttg attgcgacag gttcagaggt taatcttgct
      241 gtctcagctg ctaaagaatt ggctagtcaa ggcgaaaaaa tccgcgtagt cagcatgcca
      301 tctacagatg tctttgataa acaagatgca gcttacaagg aagagattct tccaaatgca
      361 gtccgccgtc gtgttgcagt cgaaatgggt gcaagtcaaa actggtacaa atatgttggt
      421 ctcgatggtg ccgttctagg tattaatacc ttcggagcct ctgccccagc accaaaagta
      481 ttggcagaat atggctttac tgtagaaaat cttgtaaaaa ttgttcgaaa cttgaaataa
      541 tcctaaaaat cagggcgtaa gctctggttt ttcttaccag aaaagtaagg tacaatcttg
      601 taaaagtagc tgaaatttga tatagtagtc ctatgtaaaa gacaaaggag aaagcaatga
      661 atccaaatat tactttttta atcatgcttg taggtatgat ggccttgatg ttctttatgc
      721 aacgttctca aaagaaacaa gctcaaaagc gtatggaaag cttaaataaa ctacaaaaag
      781 gctatgaagt gattacaatc ggtggacttt atggaacagt cgatgaagta gatacggaga
      841 agggaacaat agttcttgac gtagatggag tttacttgac ttttgaacta gctgctatca
      901 agacagtatt accgctgaaa gaaacagctt cactagaagg cgcaattgaa aaataagacg
      961 ggatcacgaa ctcccgtttt tctataaaag aaaggaaatg ggatgaaaaa attagtcttt
     1021 gtctgtctgg gaaatatttg ccgtagccct atggccgagt ttgttatgaa atcaatgaca
     1081 gataactacg aaatccaaag tcgagcaact tcctcttggg aacatggcaa tccgattcat
     1141 aaggggactc agggaatttt tcaagagtat gagattcctt atgacaagaa caagacatcg
     1201 cttcagatta gtaaggaaga ttttgaagcc tttgattata ttatcggaat ggacgcttca
     1261 aatatttctg acttacgtca gatgtgtcca gtagactgtc aagataagat ttactcattt
     1321 tcatctgaaa gtgttccaga cccttggtat acaggagatt ttgaagaaac ctatcgacgt
     1381 gttcaagagg gctgtcaagc ttggttagaa cgtttagaaa aggagagtta aggtggaaaa
     1441 tcttacgaat ttttacgaaa agtatcgtgt ctatctgact cgtccacgat tagagctttt
     1501 ggcagtagtt accattgttt tctgtgctgt actcgtcttt tttctaaata ttccaggaaa
     1561 aggtgtctta aaactcgata atggaacgat tgtttatgat ggcagtcttg tccgtggtaa
     1621 aatgaatggt caaggtacca ttaccttcca aaatggagac caatatacag gtggcttcaa
     1681 caatggagcc ttcaacggaa aaggtacctt tcaatctaaa gaaggctgga cctacgaagg
     1741 tgattttgta aatggtcagg ctgaaggaaa agggaaacta acaacagaac aagaagtcgt
     1801 ttatgaagga acttttaaac aaggcgtttt tcaacaaaaa taaagcctcc ttatcaaagg
     1861 aggtattatt agaatcgcaa ggtaagcgct tacctgcaaa tccctttctt tccaaatccc
     1921 tcttccaacc aagtttgtga aataaaaaat atttgaaata aatttcacaa acttcaaaga
     1981 taaaacctga taagaaaaga aaatgagaaa agtttcacaa gagtttaaaa attctttgtg
     2041 aaatgtttat gaaactgttt acaaagttga aataatgcgt tataataaac ttgtgaaaaa
     2101 attaacaaag gatatcgttc cttgaaagct atggaggaaa atatggctga taaaaaaact
     2161 gtgacaccag aggaaaagaa actcgttgct gaaaaacacg tagatgagtt ggttcaaaaa
     2221 gctctagttg cccttgaaga aatgcgtaaa ttggatcaag aacaagttga ctacatcgtt
     2281 gccaaagcat cagtagcagc tttggatgcc cacggagaat tggctttaca tgcctttgaa
     2341 gaaacaggac gtggtgtatt tgaagataaa gcaactaaga acttgtttgc ttgtgaacac
     2401 gtggtaaaca acatgcgtca cactaaaaca gttggcgtta tcgaagaaga tgatgtaaca
     2461 ggattgaccc tgattgctga accagttggt gttgtttgtg gtatcactcc aacaacaaac
     2521 ccaacatcaa cagcgatctt caaatcattg atttcattga agacacgtaa tccaatcgtc
     2581 tttgccttcc atccatcagc tcaagaatca tcagttcatg cagctcgtat cgtccgcgat
     2641 gcagctatcg cagctggtgc tcctgaaaac tgtgtacagt ggatcactga accatctatg
     2701 gaagcaacta gtgcccttat gaaccacgaa ggtattgcaa caatccttgc aacaggtggt
     2761 aatgccatgg ttaaagccgc atactcatgt ggtaaaccag ctcttggggt aggtgccgga
     2821 aacgttccag cttatgttga aaaatcagca aacattcgtc aagcagcaca cgatatcgtc
     2881 atgtctaaat catttgataa cggtatggtc tgtgcatctg aacaagcagt tatcattgat
     2941 aaagaaattt acgatgaatt tgtagcagag ttcaaatctt accacactta ctttgtaaac
     3001 aaaaaagaaa aagctcttct tgaagagttc tgcttcggcg tcaaagcaaa cagcaaaaac
     3061 tgtgctggtg caaaattgaa cgctgacatc gttggtaaac cagcaacttg gattgcagaa
     3121 caagcaggat ttacagttcc agaaggaaca aacattcttg ctgcagaatg taaagaagtt
     3181 ggcgaaaatg agccattgac tcgtgaaaaa ttgtcaccag ttattgcagt tttgaaatct
     3241 gaaagccgtg aagatggtat tactaaggct cgtcaaatgg ttgaatttaa cggtcttgga
     3301 cactcagcag ctatccacac agctgacgaa gaattgacta aagaatttgg taaagctgtt
     3361 aaagctattc gtgttatctg taactcacct tctacttttg gtggtatcgg ggacgtttac
     3421 aatgccttct tgccatcatt gacacttgga tgtggttctt acggacgcaa ctcagttggg
     3481 gataacgtta gtgccattaa cctcttgaat atcaaaaaag tcggaagacg gagaaataac
     3541 atgcaatgga tgaaacttcc ttcaaaaaca tactttgaac gtgattcaat tcaatacctt
     3601 caaaaatgtc gtgacgttga acgtgtcatg atcgttactg accatgccat ggtagagctt
     3661 ggtttccttg atcgtatcat cgaacaactg gaccttcgtc gcaataaggt tgtttaccaa
     3721 atctttgcgg atgtagaacc ggatccagat atcacaactg taaaccgtgg tactgagatt
     3781 atgcgtgcct tcagaccaga taccatcatc gcactcggtg gtgggtctcc aatggatgct
     3841 gccaaagtaa tgtggctctt ctacgagcaa ccagaagtgg acttccgtga ccttgtccaa
     3901 aaattcatgg atatccgtaa acgtgccttc aagttcccat tgcttggtaa gaagactaaa
     3961 ttcatcgcga ttccaactac atctggtaca ggatctgaag taacaccatt tgccgttatc
     4021 tctgataaag caaacaaccg taaataccca atcgctgact actcattgac accaactgtg
     4081 gcaattgtag accctgcttt ggtattgaca gttccaggat ttgttgctgc tgatactggt
     4141 atggacgtat tgactcacgc gacagaagca tacgtatcac aaatggctag tgactacact
     4201 gatggtttag cacttcaagc tattaaattg gtctttgaaa atctcgaaag ctcagttaag
     4261 aatgcagact tccactcacg tgagaaaatg cataacgctt caacaatcgc tggtatggcc
     4321 tttgccaatg ccttcctagg tatttctcac tcaatggccc ataagattgg tgcgcaattc
     4381 cacacaatac acggtcgtac aaatgctatc ttgcttccat acgttatccg ttacaacggt
     4441 acacgtccag ctaagacagc aacatggcct aagtacaact actaccgtgc agatgaaaaa
     4501 taccaagata tcgcacgcat gcttggactt ccagcttcta ctccagaaga aggggttgaa
     4561 tcttacgcaa aagctgtcta cgaactcggt gaacgtattg ggatccaaat gaattttaga
     4621 gaccaaggaa ttgacgaaaa agaatggaaa gaacattctc gtgaattagc cttcctggct
     4681 tatgaagacc aatgttcacc agctaaccca cgtcttccaa tggtagacca tatgcaagaa
     4741 atcatcgaag atgcatacta tggctacaaa gaaagaccag gacgccgtaa ataattgttt
     4801 atcagtctag aagcaagaca aaaactcaat ttgagggaaa gatccagtaa tttttctatg
     4861 ataaaaggca tcctatcaag gtttttgaac acctgatagg atgccttttt atgatattga
     4921 ggcctttttg ccctttttga aaaactagaa tagaaacaaa atatataata gattgaaact
     4981 ggaatagtac acttctgctt ctaaaaaatt gttagaattc gatttgactg tcctgatcga
     5041 tttgtcctat tcctatttca ttttattata taaaaaatat agtatagtag actgaatcta
     5101 aaatagtacg aaacaattgc taaaacattt atagaaatta attttacttt cctgatagag
     5161 ttgttcacat cttatttcaa ttcactatag tttaatttaa gagtagtatt tactaaggcc
     5221 caattaaaat caaagagcaa actagaaaac gagtgccatt cagctcaaaa cactgatttg
     5281 agattgcaga taagactagc cccctcatta acagatttac gataaaacga tgacaaggtg
     5341 tgttgctttt tgatttctaa agagtataat gatagatctc tataaaataa gtgcgaagga
     5401 aatgagcttt tatagtcctt tcgttttaaa atactatctc agatattctt atatcgacaa
     5461 gaagtttttg agtcattccc tcatcataca tattaaataa atagtggctc attcaatttt
     5521 tcactagaat aataagctag tatagtaaac tgaaataaga tataaacaaa taaattggag
     5581 cttaacatcc atttccagca attttttaga aactacagtg gactattcta gattcaacat
     5641 attataaaaa ctagagtaaa agaaaaggat tggatcttgt gtaatgcagg atccaatcct
     5701 ttcaatcatt ttgtccaact tttggaggtt cctacaatgt agtcgtcatt aataaagaca
     5761 gatgggaatg acagtgttcc tatttatttt gatagagatc gatgaattct ttagatagca
     5821 actgaataat ctctgttgaa gccatttggt cttctgcatg cataaatagc aaggagaatc
     5881 ctattttttc tccagtagct tctttttgta tgagattaga gtgaatcttg tgcgcttcta
     5941 ctaaggagtc ttccgcttct tcaactttaa ttttcgcttc ttttaaattt cctgccttag
     6001 ctagttggat ggcttcaata aaggatgatt tggctgctcc actattggca atgagctgaa
     6061 aacagatata ttccatttct tctgtcatct tatttctcct atccatgcaa gtgcttgttc
     6121 cagaactttt gctccattca tcattccgta atcccgcata tcaatggtat ctacagggat
     6181 atttcctgca atttctttca cagcaagtaa ctcataacga atttgtggcc caattagaat
     6241 gacatctgct tcatggatat tctttttagc ttctgtcatt gattttgctt ggatagagat
     6301 ttcaatccca cgttcagtcg cactttgttg cattttttta acaagcatac ttgtcgacat
     6361 tcccgcatta catactaata aaatttgttt cataatctta accttccatt tcttgttcaa
     6421 caactttgtc attaactttg ataaatggaa tgtatagaag aactccaagt gcaaagatga
     6481 tgaattgaac tagaactgct ctcacgtccc ctgctgttgc taaccatgca tttaagaata
     6541 ctggtgtagt ccaaggaact tgtataaatg caggactcat gaatcctgta actgttgcta
     6601 agtagctgat taaaatacca aggactggaa ctgtgataaa tggaatagct aatgaaatgt
     6661 tataaacgat tgggtaaccg aataatactg gttcattgat attgaagata ccaggtccaa
     6721 aagataattt agccacgttt ttagagacag cattgcgact cactaagaat gttgctatta
     6781 ataaacataa tgtagatcca ctaccaccca ttaaagcgaa tgtttgtatt tgtgataggt
     6841 tgatgatgtg tggaatggct tgtccattat ttgctgcagt gatgttttca gtaatgttaa
     6901 ttaatagtaa tggttctagg atggcactgt aaataactgc ttggtgaata ccaaatagcc
     6961 ataacatatt tcctaaagag taaataataa tgaccccgat taagcttgta ccaatatgac
     7021 gaattggttc ttgaataaag attgtaatga ttgagattaa gttcattcca gttatattga
     7081 ataataatgc tgaaacaacc ccaaataagg agatgacggt catgactgga agtaatacgc
     7141 taaatgatct actaacagct ggtggaatat tttcaccaag gttcatttgt aaagctttaa
     7201 cgtttgataa ttcaatgaat aattctgttg caataatcgc tacgataacc ccggcgaaca
     7261 ttgcgcctgt acctgtgttg ttgaatgaaa gaacacctga aatgtttaca gcatcttttg
     7321 ctccgtcagg aactacagaa actgtatttg gcatcatcac aattaaagaa actaatgata
     7381 gcattgatgc tgctaacggg ttttcgaaat ctctgttttt agctaagaaa taaccaacca
     7441 ttacagcaat aatcatacct gaaatactta aagtaccgtt tgcaattgtt attccccaat
     7501 attggaattt tgttaatgta tccccttgga aaatccactt aaataccgtg ttgttcaaaa
     7561 gaacgattaa acctgccaaa atatataatg gcattactgt tacgaatgca tctcttaggg
     7621 tttttaaatg aatttggttc cctagtttac cagcaaaggt ggcaaattga tctataaatt
     7681 ttgagttttt catctgaata tctcctctct ttactcctca atttctactt caaaaccgtt
     7741 attgtcactt actttgcgat accatcttcc tgagctcttg atggttctct tttgcgtttc
     7801 taaatcaacg gagataaatc cgtaacgatt cttatatgca ttattccaag accagcaatc
     7861 aaatgcggtc caagcgtggt atccaaaaca gtgacttccc tcttcaatgg ctttatgtag
     7921 ccatcttaaa tgttcttcat aaaattcaat acgatacacg tcatcgataa ctccattttc
     7981 atcgataaac cgtgcttcgt tttcaacacc cattccgttt tcactgataa accatggaat
     8041 attatcatat tcttccttca caatcatagc aatatcataa atggctttcg gaaaaatttc
     8101 ccaaccacga tatggattca tgcgacgctc cggccattca tactctttga agtattggtc
     8161 tggcatccag ggcgtctgat attcctcagg atttgcttgt gcttgaacac gttttggatg
     8221 gtagtagttt actccaagaa aatcaaccgt atttgatttc atcagttgaa gctctttttc
     8281 ggtatgactc cataacacgc catctctctc tagctgtttt accaatcttt ctgggaaagt
     8341 tcctttaaca gctggattca agaagacttt gttaaagaag tcttctgtaa atcgacttgc
     8401 ttctaagtct tctggagaat tacttcttgg ataagcaggt gtcaagttta aaataatccc
     8461 aatctttcca tcaagtccta atgagcgata tagttgaatc acttttgcac tagcaaggtt
     8521 tagattatag atgacttgta cggcctcttt tccctttcct tttagatttg gataatggaa
     8581 agcatataag tatcctgctt ctggaatgac cattggctca ttgaaagttg tccagtaatg
     8641 aaccttatct ccaaagcatg tgaaagcagt cttggcaaac ttcacgaata actccactac
     8701 atgtttgctt tcccaaccac cgtatttttg aagaagttcc actggtaaat caaaatgatg
     8761 taaattcatc acaagatcca tctggttctt tttagcttct tcaatgatgg cattgtagaa
     8821 agcaatacct tttggatcag gctcacctgt ctctaaattc ttgatgagtc gactccattg
     8881 gatggaagtg cggaaagaat taactccaat ttccttcatc aagtggaaat cttcggtgta
     8941 agtatgaaaa aagttactgg ctacaagagg tccgacatta tcgaaaaaat cttctggatg
     9001 cgttttgaac cagtagtcca tcacattttc atgtactttt ccatattgac cttctgtctg
     9061 aggtccgcta gaagcagctc cccaccaaaa cagattagga aatactaact tttttttcat
     9121 gctcaacctc ctttctatta ttctatacat aaagtatagc ataattttaa aatttgtcta
     9181 gacattttta aaaattgttg atacatgtct tgtgtttgcc tcatttcttg aactttgtta
     9241 tactactatt agaatattat agagagaacc agattaaatg agtacaaaat atttatttat
     9301 ttacaatgag attcgtgaaa agattctttg taataaatat accatgaacg aacaattgcc
     9361 tgatgaaatg acattagcta aacagtttgc ctgtagtcga atgacgatca aaaaagcttt
     9421 agacttgtta gtttctgagg gcttaatttt tagaaaacgt gggcagggaa cctttgttct
     9481 ctctcgtggc agctcaaaaa gaaaattaat cgttccagaa agagatatcc ggggactgac
     9541 aaaaatatct gaagatgctc attctacaat tgactcgagg attattcact tcaaattaga
     9601 atttgcaaat gaatttttag cagaaaaact acaggtcgct ttgcagagtc cagtttataa
     9661 tatttaccgt ctgcgtatta ttgacggtaa accttatgtt ctggaacaaa cttatatgag
     9721 taccgatgtt attccaggta ttactgaaga tattttacaa aaatcgattt acaattacat
     9781 tgaaggaaag ttaggattgc atattgccag tgctacaaaa atcttgcgag cttcttctag
     9841 ttcagaaaat gagcaacatt acttgcagct ccttccaacg gaaccggtat ttgaagtaga
     9901 acaagtggct tatttggata acggaactcc gtttgagtac tcgattagtc gtcatcgcta
     9961 tgatttattt gaatttaatt cttttgcatt acgacattcc tcctaggaga aaatgtgaaa
    10021 atgaagccaa tcttttacag actctagttt aagaaaaatt taaaacaggg caagaaggtc
    10081 ccatctatgc ttaaatggtt tctcttttct aaataagata gctttaaaag agtgatcgtt
    10141 ttatccatca tgttgaaaaa tatcttcgta tagcttatag agtaggtact gaaattgttc
    10201 acctgatcta cttcttatag ttatttagtt ttaaatagtg tttcaaacat tcttacactg
    10261 acgagaagtt tttgagtctt ttcttgtaac acatatagta tactgaggtt agaatagtag
    10321 actgtgactt ctaaaaaatt gctagaaatg aatttcaatc tcccaattta tttgttcata
    10381 tcttctttta atatattaaa taaattctga atcataatca tttaaaaaaa ttttattttt
    10441 tatttttcat tacgaataat atagatgaag gggaaagagt atgaaaacag aactgtttct
    10501 tttgctatta gttcaaaagg agaaaaaatg aaagtagaaa atatttcgta tagggtggat
    10561 catcgtatat tgtttgataa tatttctttt gatacttcga gttcaggcgt gacattaatt
    10621 actggtaaaa atggtacagg aaagtcaact ttactatagt agattgaaac tagaatagta
    10681 cacatctact tctaaaatat tgttagaaat cgatttgact atcctgatct atttgtcctg
    10741 ttcttatttc atttcactac atctcaaatt gagtatgacg aagtgcgctc ccatgtcctg
    10801 ggaacgcact ttcttcatat ttttcatatt cttgaatcca tcgataaaga ctattgggat
    10861 gaatttttaa agttgaacta atcattttta caggatgagg tttacagcag agagtttgaa
    10921 ggctttatca aaggtttttc ttggcataat gacttttcct cgtttccact taattttgtg
    10981 tctactttat tataccaagt ccacccttaa gttagataat aaatctaact taaggaagct
    11041 agaaggatga gaatccaggt ggtcaagagt cccaaactta agctgatggg gacacccaga
    11101 ataatttgct ttttgaaggc aaggccacgt tcctctatat tgggaagtga gagttgaatg
    11161 agagaaccag ctgatgaaaa gggtgagata ttagtagata gagcgccaat aacggtggct
    11221 gttgtgagta agtgaatatc aatctgggga ttttgagcac tgatgatagc aatgatggga
    11281 aagagggctg gagctacaac ggatagggtg gaactaaaga gtgacatcac tccggctatc
    11341 acacaaaaga acagaggtaa ccagaaatga ggaatggatg ttgtcatgag gtgccctatc
    11401 agtgtgacta aacctgactt gaccgctaga gacattagta agctcatgcc gcagagcatg
    11461 ataattgtag cccagggaac cttagctaaa atggcttctt gcttccctaa tttgagcctt
    11521 aaggcgaggc agaccatgag tattgagaca aagccaatat caaatgtttt ttgataagta
    11581 gctatccagg cgatgtttgg gaaaatgaga tgcaacaagg gaaaaagcca aaccaaaacc
    11641 atgctgctga tcatgagcaa ggtggtttgt ctttgaacct tgctgaggag tggtggttgg
    11701 tcaatagtca aggatgagtt tgtttttccc ttactatagt gactgtaaca ggataataaa
    11761 agcaagacga tgagtgggta gataatgctg acgataaaga tatgattgcc aagtgaaaaa
    11821 gcttgctctt cccatcccat ttgcttaaac aggccttgaa agacaatgcc tgagctactg
    11881 gttatcaaat tagcccctcc tgaagctccc caattgacgg cttgagctcc aatcaaaggg
    11941 tgtttgtccg ctttttgaca gagggtaatc gctagaggac agcaaacggc catagtagtg
    12001 aaaaatccag cacctaaagc agacaaaagg gttgccatca ggtataaaat catgtagagg
    12061 gcgttagggt aggtgcgtgt gcggtagaga atgtgttgag ccaaaacatc aagagtaccg
    12121 ttagttattg caaagttata aaagagagag acgctaaaaa tggtaaaaaa gagtgaggtt
    12181 ggccaaaaat gaagaagttc tttggggctt aatcccatga gagtggttgc gatgaggtaa
    12241 gaaaaagcaa tagccagcag gccaatattg attttggtgc ggtaaccaat tccaatggct
    12301 agagcaatgg cgctaatcat tattaaatga atcattgaat tgtcctttca gttagaatat
    12361 ggaaataggt tggcaatttt ggcgctcaaa agaccacctg tttcctattg gtacttgact
    12421 attatacaca aaaaaaatac aattgtcttg acaattgtat tgacacttgt tagaattaaa
    12481 aatgaggtat tcaggcttgt gatttcctat ggaagttaat agtgattgcc tctaatgctt
    12541 acaagtgata ttaaaaatag aggacttagt gatgtcaatc atttcaactg atttaacccc
    12601 ttttcaaata gatgatacat tgaaagcagc cttgcgagaa gatgttcatt ccgaagatta
    12661 cagtaccaat gccatttttg atcatcatgg ccaagccaag gtgtcgcttt ttgccaagga
    12721 agctggtgtt ttagcggggc taaccgtttt taaaagggtt tttaccctat ttgatgccga
    12781 ggtgaccttc cagaatcctc atcaatttaa ggatggggat cgtttgacta gtggcgattt
    12841 ggttttagaa atcataggct cggtgagaag tctcttaaca tgtgaacgcg ttgccttgaa
    12901 ttttttacaa catttatcag ggattgcttc gatgacagct gcttatgtag aagccttaga
    12961 cgatgattgc attaaggtat ttgatactcg aaaaactact cctaatttac gtctttttga
    13021 gaaatatgcc gtgagagttg gcggtggcta taatcatcgc tttaatttat cagatgctat
    13081 catgctaaaa gacaatcaca ttgcggcagt aggtagtgtt caaaaggcaa ttgctcaagc
    13141 gcgtgcctat gctccttttg tgaaaatggt cgaggtggaa gtggaaagcc ttgctgctgc
    13201 cgaagaagct gcggcggcgg gtgctgatat tatcatgttg gataatatgt cattggaaca
    13261 gattgaacag gccattaccc taattgcagg acgttctcgg attgaatgtt ctggaaatat
    13321 tgatatgacc actattagcc gttttcgtgg tttagcgatt gattacgtct ccagtggtag
    13381 tttaacccat agtgctaaga gtcttgattt ttccatgaag gggttaacct accttgatgt
    13441 ctaagttgta aaataaacta actttttaaa ggatgtcttt cctctagaac gagttttatg
    13501 tcagatagtt taaacgcctc ttcaa
//
LOCUS       DBMVGT010000044        13428 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.044, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000044 DBMVGT010000000
VERSION     DBMVGT010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 13428)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13428)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13428
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.044"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1186)
                     /locus_tag="AC0DU4_001442"
     CDS             complement(<1..1186)
                     /locus_tag="AC0DU4_001442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HIN4237390.1"
                     /translation="MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILF
                     YGLINPAPVDYIIYTSLAFLFYQLMIGFWGLNASISRYSKITDFMKIFFGVTASSVLS
                     YSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGA
                     GDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIER
                     VIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDITDLLGR
                     QEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVY
                     HELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFK
                     NNI"
     gene            complement(1228..2385)
                     /locus_tag="AC0DU4_001443"
     CDS             complement(1228..2385)
                     /locus_tag="AC0DU4_001443"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HIN4237391.1"
                     /translation="MSSKVSGFQDKNGKVLKIMIEWWKEKFRRVVVTQNVESLLVSIV
                     ISAYNEEKYLPGLIEDLKNQTYPKEDIEILFINAMSTDGTTAIIQQFIKEDTEFNSIR
                     LYNNPKKNQASGFNLGVKHSVGDLILKIDAHSKVTESFVINNVAIIQQGEFVCGGPRP
                     TIVEGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNE
                     QLGRTEDNDIHYRIREHGYKIRYSPSILSYQYIRPTFKKMLHQKYSNGLWIGLTSHVQ
                     FKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGF
                     LIVMPFLLFSIHFAYGLGTIVGLIRGFKWKKEYKGTIIYLDKISQINQNML"
     gene            2443..3609
                     /locus_tag="AC0DU4_001444"
     CDS             2443..3609
                     /locus_tag="AC0DU4_001444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CynX/NimT family MFS transporter"
                     /protein_id="HIN4237392.1"
                     /translation="MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSL
                     GVLTSLPLLMFTLFSPFSTQLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLM
                     VGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGL
                     ILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFY
                     TVMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVS
                     LAGVVGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGL
                     SQTGGYILAAFGPTLFGYSFDLFHSWVPSVAALLLIDILMTVALFTVDRADKIL"
     gene            3748..4074
                     /locus_tag="AC0DU4_001445"
     CDS             3748..4074
                     /locus_tag="AC0DU4_001445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HIN4237393.1"
                     /translation="MYFPTSSALIEFLILAVLEQGDSYGYEISQTIKLIANIKESTLY
                     PILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWALYTDTINGIIEGS
                     IRHDKN"
     gene            4061..4654
                     /locus_tag="AC0DU4_001446"
     CDS             4061..4654
                     /locus_tag="AC0DU4_001446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000198695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HIN4237394.1"
                     /translation="MTRTEYLTQLELYLKKLPEADRIEAMDYFRELFDDAGVEGEEEL
                     IASLGTPKEAAHEVLSNLLDKKINEAPAQKNNRQILHIALLALLAAPIGIPLGIAILV
                     TLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTVLAQAKSAFILIFGSGLLAIGA
                     SSLVLLGISYATRFFGLLIVRLVQFVLKKGKRGNQHA"
     gene            4647..5558
                     /locus_tag="AC0DU4_001447"
     CDS             4647..5558
                     /locus_tag="AC0DU4_001447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001233690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 domain-containing protein"
                     /protein_id="HIN4237395.1"
                     /translation="MRKWTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLSMSKEPVY
                     DSRTEKLTFGKEVENLEITLHQHTLTITDSFDDQIHISYHPSLSAHHDLITNQNDRTL
                     SLTDKKLSETPFLSSGIGGILHIASSYSSRFEEVILRLPKGRTLKGINISANRGQTTI
                     INASLENATLNTNSYILRIEGSRIKNSKLTTPNIVNIFDTVLTDSQLESTENHFHAEN
                     IQVHGKVELTAKDYLRIILDQKESQRINWDISSNYGSIFQFTREKPESRGTELSNPYK
                     TEKTDVKDQLIARSDDNIDLISTPSRR"
     gene            5621..6685
                     /locus_tag="AC0DU4_001448"
     CDS             5621..6685
                     /locus_tag="AC0DU4_001448"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6574 domain-containing protein"
                     /protein_id="HIN4237396.1"
                     /translation="MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEETIANLDTPIGK
                     NTQVEEEVSQAEVELESQQEEKIETPEGGEARTEIEEKKASNSTEEEPDLSKETEKVT
                     IAEESQEALPQQKATTKEPLLISKSLKSPYIPDQAPKSRDKWKEQVLDFWSWLVEAIK
                     SPTSKLETSITHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIASINSRFPEQLAPLT
                     LFSIISILVATTLFFFSFLLGSFVVRRFIHQEKDWTLDKVLQQYSQLLAIPIFLTAIA
                     SFFAFFDSLRFTALLCVISIGIILLASLHIITRPSQASETDSFYQLFLSVLVNGVIIL
                     LFFVAEVALIGDYLRILAFL"
     gene            complement(6757..7617)
                     /locus_tag="AC0DU4_001449"
     CDS             complement(6757..7617)
                     /locus_tag="AC0DU4_001449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4299 family protein"
                     /protein_id="HIN4237397.1"
                     /translation="MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQ
                     PLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDLPDLLTKTDWQIIKSFLDALLAYT
                     GTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEADGLA
                     QFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLV
                     DKEVQWEIDLVQITGDGSKPEDYESIARLDYAKFLEVLPPSFYHQLDANQIEVQPILD
                     KDFKTLAQEK"
     gene            complement(7739..8725)
                     /locus_tag="AC0DU4_001450"
     CDS             complement(7739..8725)
                     /locus_tag="AC0DU4_001450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-related sulfurtransferase"
                     /protein_id="HIN4237398.1"
                     /translation="MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADE
                     GINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEENEQAFKKMFVRYKKEIVHLGLE
                     DNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRN
                     FRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKD
                     PEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILT
                     SEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV"
     gene            complement(8997..10472)
                     /locus_tag="AC0DU4_001451"
     CDS             complement(8997..10472)
                     /locus_tag="AC0DU4_001451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4237399.1"
                     /translation="MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIK
                     MYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAF
                     ADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQ
                     NFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPV
                     ANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQD
                     TWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEK
                     SMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNW
                     ILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINT
                     GTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK"
     gene            complement(10556..11479)
                     /locus_tag="AC0DU4_001452"
     CDS             complement(10556..11479)
                     /locus_tag="AC0DU4_001452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001075101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4237400.1"
                     /translation="MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVF
                     VIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNV
                     FITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVP
                     MLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTA
                     LGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMA
                     MVVVATLPIAILYPFFQRYFVKGLTIGGVKE"
     gene            complement(11493..12422)
                     /locus_tag="AC0DU4_001453"
     CDS             complement(11493..12422)
                     /locus_tag="AC0DU4_001453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237401.1"
                     /translation="MKKFSKTLRDNWIFLLMVLPGALWLILFFYIPVFGNVVAFKDYH
                     MTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAII
                     LSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFY
                     ADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIP
                     QLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGM
                     AAAAGLYQSVVGLILVILSNLLARRVDPNSALF"
     gene            complement(12741..13091)
                     /locus_tag="AC0DU4_001454"
     CDS             complement(12741..13091)
                     /locus_tag="AC0DU4_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237402.1"
                     /translation="MTGVSNPTTDSARLVLAEAKKALTDDSLTEQGLRDILQTVKDAI
                     ASLESIKESQSATKDGGQTAGKETADKDVLENSQEELQKAVLFLADEKGSEHTEAELI
                     DNLKEVIAKLKANA"
BASE COUNT         4038 a         2871 c         2463 g         4056 t
ORIGIN      
        1 ggatattgtt tttgaaggct tcttttggat tgcgctccat cataggaaca tgcttgtggg
       61 ctgccgcatg ataaacaata gcaggtttgt actgctcaaa gacttgcaac aaacgatcat
      121 agtcttgaat gtccgcaatc acaggtacat aatcaatccc ttggaactta cgaatcaatt
      181 catgataaac aaggtagatt gagttttccc catgaccgag caagacaatg cgttcaggat
      241 tgaagcgact aacttgacga cagatttcag aaccgattga acctccagct cctgtgacta
      301 agatggtctt acctgtcagt tctgcaccca gacgcgattc gtcaagacgg atttcctgac
      361 gacccaaaag gtccgtaata tcaatttttt ggaagccagt acctgcttgg tgaaggccct
      421 gaacaacagt ttcaacctta ggcatcttgt aacatttgac acccagctta ttacacatct
      481 gcaagatacg ctcatattct gacggatcca gcgacggaat cgcaacgatg acacgctcga
      541 tttgatggcg tttggctaat tcaggcagat tgtcataaga gcccaaaaca ggaataccac
      601 caagtttttg accctttttc ttagaatcct tatccaaaat accgaccagt tctaattcac
      661 tggttggatg ttggtaacta tccataaaga gagccccacc atcaccggca ccaatcaaga
      721 aggtccgacg gtgttctcca tcaccactac cttttttgcg tctggagtag attaactgcc
      781 aagtaatccg tggcaataaa atcaagaagg tactcaacaa gataaagaga atgatgaaac
      841 ggatggagaa gagtggcaag aaggcataac agatactata tgacaagaca ctgctagcag
      901 tcacaccaaa aaagattttc atgaaatccg taatcttgct gtaacgacta atgctcgcgt
      961 tcaaccccca aaaaccaatc atcaattgat agaacaagaa ggccaaactc gtatagataa
     1021 tgtagtcaac aggtgctgga ttaatcagcc cataaaataa aatataagat acaattatgg
     1081 aaaccaccat actgaaaata tcaaatattc cccagaaaac ctgcttttgt tgtttattta
     1141 aaatttccac cagatcaatc acataatctg ttagtttttt attcatagaa atctactcct
     1201 ccttaaaaga gttttactat attgttatta tagcatattt tgatttattt ggcttatttt
     1261 atccaaataa attattgttc ccttgtactc cttcttccat ttaaatcctc taattaaacc
     1321 tacaatcgtc ccaaggccat aagcaaagtg aatggaaaat aaaagaaagg gcatcacaat
     1381 tagaaatcca tttttatgtt ttaataaagt cagcaaagtg agtaatgaca aaagtagaaa
     1441 ataggcacct aatagtaaag ttatgaatac gaatgtgatc ggtaacaatg ctagactaaa
     1501 cacaagactc aaaacaaata aacaaggaac atagtgaaat aatgataaac acttaaactg
     1561 aacatgactt gtcaagccaa tccacaaacc atttgaatac ttttgatgca gcattttctt
     1621 gaatgttggt cgaatatact gataagatag aatacttggg ctatagcgga ttttataacc
     1681 atgttctcga attctataat gaatatcatt atcttcagtt cggccaagtt gctcatttac
     1741 taaaccaacc ttctggaaaa cctctcgttt atacatccca tgaaaaatag aagaaacata
     1801 tctatcctcg gaactatttc gataattggc aatgctactg ccaaacatat tttcctcaac
     1861 aagatgcaag gtctctgccc attttccttt tccttcgaca atcgtcggtc taggcccccc
     1921 acagacaaat tcaccttgtt gaataatagc cacattgtta attacaaaac tctcagtaac
     1981 ttttgaatga gcatcaattt ttaaaataag gtcccctaca gaatgtttaa ctcccaggtt
     2041 aaaaccacta gcttgatttt tcttaggatt gttatacaat ctaattgagt taaactctgt
     2101 atcttccttt ataaattgct gaatgatagc tgtggtccca tctgtggaca tagcatttat
     2161 aaatagaatt tcaatatcct ctttaggata ggtttgattt tttaagtctt caattagacc
     2221 aggcagatat ttttcttcat tgtatgcact gattacaatg gatacgagaa gactttcaac
     2281 attttgagtc actactactc tcctgaattt ttccttccac cattctatca taattttcaa
     2341 gactttccca tttttatctt gaaagccaga aaccttactt gacattatag tgaaaaagcc
     2401 ttaaaataag ctgttattaa aatcagctag aagaggtatt atatgaaaaa gcaatcactc
     2461 ttttttgttc caggtattat cctgattggt gtttccttgc gaactccttt tactgtttta
     2521 cccattattt tgggaaatat ttcgcaaggt ctggaggtag aagttagttc gcttggtgtc
     2581 ttgaccagcc tgcctctcct tatgtttacc ctcttttcac cattttctac ccaactggct
     2641 cagaaaatcg gcttggagca tctcttcacc tacagcctct tcttcttgac catcggctca
     2701 cttattcgac taatcaatct gcccctgctc tatctaggaa ccttgatggt tggggcaagt
     2761 gtcgcagtca tcaatgtcct gcttcctagt cttatccaag ccaatcaacc aaagaaaatt
     2821 ggttttctga ccaccttata tgtaacgtct atggggattg caacggctct ggcttcctat
     2881 ctagctgtgc ccattacaca agccagttct tggaaaggac ttatccttct cctcacgtta
     2941 ctctgtctag caactttttt ggtctggctc ccaaatcacc gctataatca tagactagct
     3001 ccacaaacca aacaaaaaag tcaaataaag gtcatgcgta ataaacaggt ttgggcaatt
     3061 attatctttt caggttttca atccttgatc ttttacaccg tcatgacctg gttacctacc
     3121 atgtctatcc atgcaggtct atccagtcac gaagctggct tgctgacttc tatcttatct
     3181 ctgattagca ttcctttttc aatgaccatc ccaagcctga caaccagttt atctactcgc
     3241 aaccgtcagc tcatgctcac tctggtttca ctagctggtg tggtcggcat ttccatgctc
     3301 tttttcccaa tcaataattt catttactgg cttgccatcc atctcctcat cggaaccgca
     3361 accagtgccc tcttccctta tctcatggtc aacttttcac tcaagacaag cgcccctgaa
     3421 aagacagccc aattgtccgg cctatctcaa acaggaggct atatcctagc agcctttggg
     3481 ccaaccctct ttggttacag ttttgacctg ttccactctt gggtaccatc tgtagctgcc
     3541 ctcttgctca tcgatatcct gatgactgtg gccctcttta cagtggacag agcggataag
     3601 atcctttaaa cttctagttt tagctagaag ttttttatat ataaaaattt tacacatttc
     3661 tcttgacagg gctttctttt agatgtacaa tgtatgtgta gaaaaattat atataaaaat
     3721 cttacacatt agaaaaggag gtttcccatg tactttccaa catcctctgc cttgattgaa
     3781 tttctcatct tggctgtact ggagcagggt gattcttatg gttatgagat tagccaaacc
     3841 attaagctga tcgctaatat caaagaatcc acactctatc ccattctcaa aaaattggaa
     3901 ggcaatagct ttctgacaac ctattctaga gagttccaag gtcgcatgcg caaatactac
     3961 tccttgacaa acggtggtat agagcagctc ttgaccctaa aagatgaatg ggcactctat
     4021 acagacacca tcaatggcat catagaaggg agtatccgcc atgacaagaa ctgaatacct
     4081 gactcagcta gaactctatc tcaagaaact acctgaagct gaccgtatcg aagccatgga
     4141 ctatttcaga gagctctttg acgatgctgg agtcgaagga gaagaagaac tcatcgctag
     4201 tttgggaact cccaaagaag cggcccacga agttctatcc aatcttctcg ataaaaaaat
     4261 caatgaagca cccgctcaaa aaaataaccg acaaatttta catatcgcct tgttagccct
     4321 ccttgcagca cctatcggca ttcctctggg aatcgccatc ctcgtgaccc tgttcgcaat
     4381 tcttgtagcc gctttgactg tcattctggc tttctttgca gtttccatac tgggtatcat
     4441 cggcggattc ctatttttag ttgaaagttt cactgtcctc gcccaagcca aatcagcctt
     4501 tatcttgatt tttggttctg gtttactggc tatcggtgct tcttcgctag ttttacttgg
     4561 catttcctat gcaactcgct tcttcggtct actcattgtt cgtctggtac aatttgttct
     4621 taaaaaagga aagagaggta atcagcatgc gtaaatggac aaaaggattt ctcatctttg
     4681 gtgtggtgac taccgttatc ggctttatcc tgctttttgt aggtatccaa tctgacggga
     4741 ttaagagcct actttccatg tccaaagaac ctgtctatga tagccgtacg gaaaagctaa
     4801 cctttggcaa ggaagtcgaa aacctagaaa ttactctcca ccaacacacg ctcaccatca
     4861 cagactcttt cgatgatcaa atccacattt cttaccatcc atctctttct gctcaccatg
     4921 atcttatcac caatcagaac gatagaactc tgagtctcac tgataagaaa ctgtctgaaa
     4981 ctccgtttct ctcttctgga attggtggga ttcttcatat cgcaagtagc tactctagtc
     5041 gttttgaaga agttattctc cgactaccaa aagggagaac tctaaaaggg atcaacatct
     5101 cagccaatcg cggacaaacc accatcataa atgctagcct tgaaaatgcg accctcaata
     5161 caaacagcta tatcctccga attgaaggaa gtcgtatcaa aaacagtaaa ctcacaacgc
     5221 ccaatatcgt taatatcttt gatacagttc ttacagatag tcagctagag tcaacagaga
     5281 atcacttcca cgctgaaaat atccaagtcc atggcaaggt tgaactgact gccaaagatt
     5341 atctcagaat catcctagac cagaaagaaa gccaacgaat taactgggac atctcaagca
     5401 actatggttc tatcttccaa ttcacaagag aaaagcctga atcaagaggt acggaattaa
     5461 gcaaccctta caaaactgaa aaaaccgatg tcaaggatca actcattgcg agatctgatg
     5521 ataatattga tctaatatcc acaccaagca gacgttgaca aaaacgctta catttgctac
     5581 tatggaaaca tatttatcta actaaaaagg aggttctacc atgaaacaag aatggtttga
     5641 aagtaatgat tttgtaaaaa caacaagcaa gaacaagcct gaagagcaag ctcaagaggt
     5701 tgcagacaag gctgaagaaa cgatagccaa tctcgataca ccaattggaa aaaatactca
     5761 agtagaggag gaagtctctc aagctgaagt cgaactggaa agccagcaag aagagaaaat
     5821 tgaaactcct gaaggcggtg aagcgagaac agaaatagaa gaaaagaagg catctaattc
     5881 tactgaagaa gagccagacc tttctaaaga aacagaaaaa gtcactatag ctgaagagag
     5941 ccaagaagct cttcctcagc aaaaagcaac cacgaaagag ccacttctta tcagtaaatc
     6001 tttaaaaagt ccttatatcc ccgaccaagc tccaaaatct agggataaat ggaaagagca
     6061 agtgcttgat ttttggtctt ggctagtaga agcgatcaaa tctcctacaa gtaagttgga
     6121 aacaagtatc acacacagtt acacagcctt tctcttgctc attctgtttt ctgcatcttc
     6181 ctttttcttt agtatctatc acatcaaaca tgcttactat ggacatatag caagcattaa
     6241 cagtcgcttc cctgagcagc tagctccttt aactcttttt tctatcatct ctatcctagt
     6301 agcgacaaca ctcttcttct tttcattcct cttgggtagt ttcgttgtga gacgatttat
     6361 ccaccaggaa aaggactgga cgctagacaa ggttctccaa caatatagtc aactcttggc
     6421 aattccaatc ttcctcactg ctattgctag tttctttgct ttctttgata gcctacgatt
     6481 tacagctctc ttgtgtgtga ttagcattgg aatcattctg cttgccagtc tccatatcat
     6541 tacaagacca agtcaagcaa gtgaaaccga ctccttctat caattattct tgtctgtcct
     6601 tgtgaacgga gttattatcc tcctcttctt tgtagctgaa gtggcactga ttggagatta
     6661 tcttcgtatc ttggcctttc tttaaaattc aatcctgtca tccttggcag gattttttct
     6721 atgtcaaaaa agcaagtcga ttgacctgct tctgctttac ttttcttgtg ctaatgtttt
     6781 aaaatctttg tctaatatgg gttgcacttc tatttgattg gcgtctagtt ggtggtaaaa
     6841 agatgggggt aatacctcta agaattttgc atagtccaag cgagctatgg attcatagtc
     6901 ttctggttta gagccgtctc ctgtgatttg aaccaagtca atctcccact ggacttcctt
     6961 atccaccaat tgctcaatat aggctgcagg aacaaacggt tctctcggta aaactgtctt
     7021 gactccttga gctaaatggt aaacgccatg cacttttcct tctccatcct gatagaagga
     7081 aactcttgca aagtaggcat ctgtctcttg aaccgcacgc acacgcgctt caaactgagc
     7141 caagccatct gcctctaaaa agcttttcaa gttctcacga ctaaagaaaa taggattaaa
     7201 aattccttgg caaatcgtaa aacgagctac agggtctgct agataggctt gaatacttgc
     7261 ttggaaataa gcttcaaaat caaaaccatc tagcccttca atatcagtcc ctgtataagc
     7321 aagcaaagca tctaaaaatg acttgataat ctgccagtct gtctttgtta gtaggtcagg
     7381 aagatcgaca cggtaagcct tttgaccatc agcataactg accttaaaga gaaattgtga
     7441 ttgccccact atcgcacact caatatactc gagacgatta agaggctgac gaagatagac
     7501 tacatcatag ctatgtgact ccaaaccgtc tagcaaggcc aagatcgact tggcattcaa
     7561 aatctcttgt tctcctaaaa tgctctgttt atttggaata aaaaatgttt ttgccataac
     7621 tggactcctt tgaaatcgtt tacatacagt ataccttatt ttcctgaaag atacaaaaac
     7681 aaactttaga tttttgagta caaagcatag aaaaacagcc cctgaggact gtttgatctt
     7741 atacagtagc tgcctgatcc aagctttcac cgatagcggc taggcgctca atcacttcag
     7801 cttgtgtcaa ttcatttttt gaaacatagc ggttacgtgg gtgaacacgg cactcgtgtg
     7861 agcatccacg aaggtacttg tcttcatttt cttctgatgt caagatacga cggttacaga
     7921 agggatttcc acagttgaca taacgttcac atggtgttcc atcaaaccag tctttcccta
     7981 cgatggttgg gttgacatgg ttgacatcaa cggcaatacg ctcgtcaaag acgtacattt
     8041 tcccatccca aagctcacct tgaacttctg ggtctttacc gtaagttgcg attcctccgt
     8101 gcaattggcc gacatctttg tagccttcac ggaccatcca gcctgagaat ttctcacagc
     8161 gaacgccacc tgtacagtaa accacgacac gcttgtccat gaatttttcc ttgttatcac
     8221 ggacccattg tggtaactca cggaagttgc gaatatctgg gcgaatagcc ccacggaaat
     8281 gtcctaggtc gtactcataa tcgttacgtg tgtcaaggac aacggtatct ttatcaagaa
     8341 gcgcttcttt gaactctttt ggagacaagt aagcacctgt tgtttcaagt gggttgatgt
     8401 cattgtcaaa gtcgttgtct tccaaaccaa ggtggacaat ttctttcttg tagcgaacaa
     8461 acatcttctt gaaggcttgt tcattttctt cgtcaatctt gaaccagagt tcttccattc
     8521 ctggaaggct gtgaacgtag tccatgtatt tttgagttgt ttcatagtca cctgaaactg
     8581 ttccgttaat tccctcgtca gcgactagga tacggccttt aaggccgatt gatttacaga
     8641 aagccaagtg gtctgcagca aattgctctg cattttcaat tggagtataa aggtagtaaa
     8701 gtaagacacg aatatctttt gccataagat ttgttctctt ttctattctt aaattttcta
     8761 aattttttat ttatctacac tagtatacct gcttgagaaa acgaatgcaa tttatttgac
     8821 tggaaattgt agagggttct cgaaatttcc tgaatggtta aaataaggac aagagaaaac
     8881 atggatatct atatccttgt gccaaaaaaa ccactgccct ccccagacca acctgaggaa
     8941 agcggtgatt cttattttag gagttaggaa tgaatacacg aaatcaattt agctgattat
     9001 tttttgtttt tcaagaattc atcgtattgt ttttgcattt cgttcaatac tttttcgtag
     9061 gcaccttcag atttcaattt ttccatcaat tctggaatcg ctttatctgg gtctacagta
     9121 ccagtgttga tagctgtatc aaattgttgc attgtgttag caatagctga gatttcagat
     9181 ttcacattgt cagtattgaa gataaatcca agcgctggag attctttagc ttctgccaat
     9241 tctttcttag aattttcgat ttgttggtct gtaacgtttt cgttgatgta aaggatccag
     9301 ttgttaccag tgttccatcc acccatgtga gtgtttcctt tgtagccatc aagaacgcga
     9361 acacggtttt ctttaccttc aattttttcc cagttcttgc cttctggacc gtaaacaaga
     9421 ccgttcaaaa gttctgggtt cgtattcaag aggttcaaga tttccattga tttttctttg
     9481 ttcttagagt tgtttgagat gacaaagtta gcaacttgtg ttgtttggtt tttcttgatg
     9541 aagttagtga ttggtttgat ttggatatct ttgttggcaa cacgtgaaag caagctgtta
     9601 ccgtagtcag ctggtcctac tgtttcttca cgaacgaacc aagtatcttg ttgaaggtca
     9661 aatgaagtgt cacttgttgc gacgtctttt ggaatgtagc cagcttcata gaatttgtga
     9721 agagtcttca agtgttcttt gaaacgaggc acttcgtaac ggtttacaac tttagtagta
     9781 tcgccttcaa ggtcaataac gaatggaagc ccgtttgcta ctgggtagtc aaagttatca
     9841 gatgggatga aaactttacc aatagcaaat ggtactacgt ctggagcttt ttctttgatt
     9901 tgtttcaaga ctggctcaag agtttcgtaa gaagtaacac ctgaaatatc gataccatat
     9961 ttggcaagga gagttccgtt gaaggcaaag ttttgagatg atgctacgtt ggctgcaact
    10021 ggtacagcgt aaatcttacc atttacagta ttacccttga tataagctgg atcaagtgcc
    10081 ttgtaaaggt ctttaccttc ttttttgtac aattctgtca agtcagcata agcacctttt
    10141 tgagcattta caatatagtt atctgcaaag gcgatatcat agttttcacc agatgatgtg
    10201 ataactgaca ttttcttacc atagtcaccc cagccaaggt attggatatc caatttggca
    10261 ccaacttttt cttcgatgat tttgttggca tttgctaaca attcatccaa gttatctggt
    10321 ttgtcaccga tttggtacat tttgataaca ggtttgtcac ctgaatcagc agcttttttg
    10381 ctgttacctg tcaaatttcc acaagcagca agacctgcag ccaaagcgac tacactagca
    10441 gatgcaaaag catatttttt ccagtttttc atgataaaaa ctcctttttt tatttttaaa
    10501 cttataaaca atgtaatgat cttaacttca cgcaagggaa gtttggaaac aagtgctatt
    10561 ctttcacacc accgatagtc aaacctttta caaagtagcg ttggaagaat ggatacaaaa
    10621 ttgcgattgg aagggttgct accacaacca tggccatacg acctgtttct ttcggtagag
    10681 caactcccag ttgaccagtc aagccgaccg ctttggcaat gtagtccata ttttgttgga
    10741 tttgcatgag caaatattgc aatggataca agttgtcact cttgatgtaa agaagggcgt
    10801 tgaaccagtc attccagaaa ccaagagctg tcaaaagcgt gatggttgcg atacctggta
    10861 gtgacaatgg caaacagatt tggaagaaaa tccgggcctc actggcacca tcgatacgag
    10921 ccgattcgag aatggcttct ggaatggtct tcttgaagaa ggaacgcatc aagatgatat
    10981 tgaatggtga gagaagcatt ggaacaatca aggcccaaac agtgtcacca agctgaagta
    11041 cacgggtcac catgatataa cctggtacca aaccagcgtt gaacaacata ctgagaagga
    11101 cgaagatggt aaaaaatctg cgatacttaa aggttgtccg tgaaatagcg taggcatagg
    11161 ttgttgtgat aaagacattt gtcaatgtcc caactacggt tacaaagaca gagatgaaga
    11221 gggcttgtag gattttatcc ttaaactgtg ccaaaaactc aaaaccgtct aagccaaatt
    11281 gggatgggaa gaagctatag ccgtattgga ggaggctttt ctcgtctgtc actgaaataa
    11341 tgataacgaa tacaaaaggt aggatacaag agagggcaat caaacccgaa atgatactga
    11401 agaagatatc tgctttctta ctgaaggagt gaatgccgac attatcaatt ttttcttttt
    11461 taattttctt ttttgccata ttctcctcct ttctagaaca aagctgagtt tggatcgact
    11521 cgtcttgcaa gcaagtttga taggataacc agaatcaaac caacaacgga ttggtaaaga
    11581 ccggctgctg cagccatacc gatatctgct gtctgagtca aaccattaaa aacatatacg
    11641 tccaaaacgt tggttacatt gtaaagctga ccagcattgt gtgggatttg atagaagaga
    11701 ccgaagtctg cgcggaagat atttccgact gcaaggatgg tcaatacagt tacaagcgga
    11761 gtcaactgag gaatggttac gttgcgaata cgttgccact tgctagctcc gtccactgtc
    11821 gctgcttcgt agtaggttgg atcaattccc atgatcgtcg catagtacat gacactgcta
    11881 tatccaaaac ctttccaaat acctaggaaa agtaggagat agggccagat gcccaggtca
    11941 gcgtagaaat tgacttcttt gagaccaaga ctttccaata gatgattgaa caccccttta
    12001 tcaatattta ggaaggcatc tgtaaagaaa ctgatgataa cccaagacaa gaagtaaggg
    12061 aacaacatag aagtttggaa aatcttcacc attctcttag aacggagctc gctgaggata
    12121 atggcaatcc ctacagatac aactaaacct agaaagataa agccaagatt gtagaggaca
    12181 gtatttcgtg tgataataaa ggcgtctctt gaactaaata agaatctgaa attatcgagt
    12241 ccgacccatt tactatttat gatactatct atgaaaccat tactggtcat gtggtagtct
    12301 ttgaaggcaa ccacgttccc aaatactgga atgtaaaaga atagaatcaa ccagagtgcc
    12361 cctggcaaaa ccatcaagag aaagatccag ttgtctctca atgtttttga aaactttttc
    12421 ataatttcct ccctttttat tttgatatcc atctaaaaat tcttttttag acttttgata
    12481 acgattacat tattagtata ctcctatttg caggttaggt taaactccta attatagaaa
    12541 aaattccaca aattatgtag cagatttaaa actttatcac cactatcaaa caaatgtcct
    12601 aaatcaattg tttattttat ctctattagc ccagtgatgg cgtcactctg ttataagcat
    12661 ccaacaacgg ggtatactga aaaatctcca gactagggaa ctcagcgata gttcctaatc
    12721 tggagatttt taatatgtta ttaggcgttt gctttcaact tagcaataac ctctttaaga
    12781 ttatcaatca actctgcttc agtatgctca gagccttttt catctgccaa gaacaaaact
    12841 gctttttgaa gttcttcttg agagttttca aggacatcct tatctgctgt ttctttgccc
    12901 gctgtttgtc ctccatcctt agttgctgac tggctttcct taatggactc tagggaagca
    12961 atggcatctt tgactgtttg caagatatca cgtaaacctt gctctgtcaa actatcatct
    13021 gtaagagctt tcttagcctc tgccaaaacc agacgtgctg aatctgtggt aggattcgat
    13081 acacctgtca atgatctcaa aagattttct aaggtttgag tctgcttact aatactagac
    13141 taaaatcaaa aagcattaca taacagtgat atgaaatcaa ctaaagaaga aatccaaacc
    13201 atcaaaacac ttttaaaaga ctctcgtaca gctaaatatc ataaacgcct tcaaatcgtt
    13261 ctatagtaaa atgaaacaag aacaggacaa atcgatcagg acagtcaaat cgatttctaa
    13321 caatgtttta gaagtagagg tgtactattc tagtttcaat ccattatatt tcgtctgatg
    13381 ggcaaatctt ataaagagat tatagagctt ttatagtgat ttgaaata
//
LOCUS       DBMVGT010000045        13311 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.045, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000045 DBMVGT010000000
VERSION     DBMVGT010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 13311)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13311)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13311
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.045"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..413
                     /locus_tag="AC0DU4_001455"
     CDS             <1..413
                     /locus_tag="AC0DU4_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001289361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="TOBE domain-containing protein"
                     /protein_id="HIN4237403.1"
                     /translation="EFVATFIGRTNIIPANLEKRSDGAYIVFSDGYALRMLALDQVEE
                     QAIHVSIRPEEFIKDESGDIEGTISDSVYLGLNTEYFIETGFASKIQVSEESTFEEDL
                     QKGNRIRLRINTQKLNIFSADGSQNLIKGVNHGT"
     gene            403..2048
                     /locus_tag="AC0DU4_001456"
                     /pseudo
     CDS             403..2048
                     /locus_tag="AC0DU4_001456"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520796.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
     gene            complement(2151..2843)
                     /locus_tag="AC0DU4_001457"
     CDS             complement(2151..2843)
                     /locus_tag="AC0DU4_001457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HIN4237404.1"
                     /translation="MVKVRLYLVRHGKTMFNTIGRAQGWSDTPLTAEGERGIQELGIG
                     LRESDLQFERAYSSDSGRTIQTMGIILEELGLQGKIPYRMDKRIREWCFGSFDGAYDG
                     DLFMGIIPRIFNVDHVHQLSYAELAEGLVEVDTAGWAEGWEKLSGRIKEGFEMIAKEM
                     EDQGGGNALVVSHGMTIGTIVYLINGMHPHGLDNGSVTILEYEDGQFRVEVVGDRSYR
                     ELGREKMEEGSI"
     gene            complement(3087..4424)
                     /locus_tag="AC0DU4_001458"
     CDS             complement(3087..4424)
                     /locus_tag="AC0DU4_001458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PFL family protein"
                     /protein_id="HIN4237405.1"
                     /translation="MDIRQVTETIAMIEEQNFDIRTITMGISLLDCIDPNINRAAEKI
                     YQKITTKAANLVAVGDEIAAELGIPIVNKRVSVTPISLIGAATDATDYVVLAKALDKA
                     AKEIGVDFIGGFSALVQKGYQKGDEILINSIPRALAETDKVCSSVNIGSTKSGINMTA
                     VADMGRIIKETANLSDMGVAKLVVFANAVEDNPFMAGAFHGVGEADVIINVGVSGPGV
                     VKRALEKVRGQSFDVVAETVKKTAFKITRIGQLVGQMASERLGVEFGIVDLSLAPTPA
                     VGDSVARVLEEMGLETVGTHGTTAALALLNDQVKKGGVMACNQVGGLSGAFIPVSEDE
                     GMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPAETIAAMIADEAAIGVINMKT
                     TAVRIIPKGREGDMIEFGGLLGTAPVMKVNGASSVDFISRGGQIPAPIHSFKN"
     gene            complement(4434..4700)
                     /locus_tag="AC0DU4_001459"
     CDS             complement(4434..4700)
                     /locus_tag="AC0DU4_001459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002905356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HIN4237406.1"
                     /translation="MKAIITVVGKDKSGIVAGVSGKIAELGLNIDDISQTVLDEYFTM
                     MAVVSSDEKQDFTYLRNEFEAFGQTLNVKINIQSAAIFEAMYNI"
     gene            complement(4965..5351)
                     /gene="rplQ"
                     /locus_tag="AC0DU4_001460"
     CDS             complement(4965..5351)
                     /gene="rplQ"
                     /locus_tag="AC0DU4_001460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HIN4237407.1"
                     /translation="MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTV
                     EKMITLGKRGDLHARRQAAAFVRNEIASENYDEATDKYTSTTALQKLFSEIAPRYAER
                     NGGYTRILKTEPRRGDAAPMAIIELV"
     gene            complement(5363..6298)
                     /locus_tag="AC0DU4_001461"
     CDS             complement(5363..6298)
                     /locus_tag="AC0DU4_001461"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HIN4237408.1"
                     /translation="MIEFEKPNITKIDENKDYGKFVIEPLERGYGTTLGNSLRRVLLA
                     SLPGAAVTSINIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKIIELDVEGP
                     AEVTAGDILTDSDIEIVNPDHYLFTIGEGSSLKATMTVNSGRGYVPADENKKDNAPVG
                     TLAVDSIYTPVTKVNYQVEPARVGSNDGFDKLTLEILTNGTIIPEDALGLSARILTEH
                     LDLFTNLTEIAKSTEVMKEADTESDDRILDRTIEELDLSVRSYNCLKRAGINTVHDLT
                     EKSEAEMMKVRNLGRKSLEEVKLKLIDLGLGLKDK"
     gene            complement(6341..6724)
                     /gene="rpsK"
                     /locus_tag="AC0DU4_001462"
     CDS             complement(6341..6724)
                     /gene="rpsK"
                     /locus_tag="AC0DU4_001462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HIN4237409.1"
                     /translation="MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNAIAWSS
                     AGALGFKGSRKSTPFAAQMASEAAAKSAQEHGLKSVEVTVKGPGSGRESAIRALAAAG
                     LEVTAIRDVTPVPHNGARPPKRRRV"
     gene            complement(6742..7107)
                     /gene="rpsM"
                     /locus_tag="AC0DU4_001463"
     CDS             complement(6742..7107)
                     /gene="rpsM"
                     /locus_tag="AC0DU4_001463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HIN4237410.1"
                     /translation="MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDVR
                     VRDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNT
                     KNNARTRKGKAVAIAGKKK"
     gene            complement(7125..7241)
                     /gene="rpmJ"
                     /locus_tag="AC0DU4_001464"
     CDS             complement(7125..7241)
                     /gene="rpmJ"
                     /locus_tag="AC0DU4_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013773089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HIN4237411.1"
                     /translation="MKVRPSVKPICEYCKVIRRNGRVMVICPANPKHKQRQG"
     gene            complement(7266..7484)
                     /gene="infA"
                     /locus_tag="AC0DU4_001465"
     CDS             complement(7266..7484)
                     /gene="infA"
                     /locus_tag="AC0DU4_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003743 - translation initiation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006413 - translational initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HIN4237412.1"
                     /translation="MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNY
                     IRILAGDRVTVEMSPYDLTRGRITYRFK"
     gene            complement(7601..8239)
                     /locus_tag="AC0DU4_001466"
     CDS             complement(7601..8239)
                     /locus_tag="AC0DU4_001466"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HIN4237413.1"
                     /translation="MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTE
                     MGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLT
                     ELGIELEGVINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDK
                     PETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK"
     gene            complement(8390..9700)
                     /gene="secY"
                     /locus_tag="AC0DU4_001467"
     CDS             complement(8390..9700)
                     /gene="secY"
                     /locus_tag="AC0DU4_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0015031 - protein transport [Evidence IEA];
                     GO_process: GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HIN4237414.1"
                     /translation="MFFKLLREALKVKQVRSKILFTIFIVLVFRIGTSITVPGVNANS
                     LNALSGLSFLNMLSLVSGNALKNFSIFALGVSPYITASIVVQLLQMDILPKFVEWGKQ
                     GEVGRRKLNQATRYIALVLAFVQSIGITAGFNTLAGAQLIKTALTPQVFLTIGIILTA
                     GSMIVTWLGEQITDKGYGNGVSMIIFAGIVSSIPEMIQGIYVDYFVNVPSSRITSSII
                     FVIILIITVLLIIYFTTYVQQAEYKIPIQYTKVAQGAPSSSYLPLKVNPAGVIPVIFA
                     SSITAAPAAILQFLSATGHDWAWVRVAQEMLATTSPTGIAMYALLIILFTFFYTFVQI
                     NPEKAAESLQKSGAYIHGVRPGKGTEEYMSKLLRRLATVGSLFLGVISILPIAAKDVF
                     GLSDVVAFGGTSLLIIISTGIEGIKQLEGYLLKRKYVGFMDRTE"
     gene            complement(9713..10153)
                     /gene="rplO"
                     /locus_tag="AC0DU4_001468"
     CDS             complement(9713..10153)
                     /gene="rplO"
                     /locus_tag="AC0DU4_001468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004225266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HIN4237415.1"
                     /translation="MKLHELKPAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGG
                     GVRLGFEGGQTPLFRRLPKRGFTNINAKEYAIVNLDQLNVFEDGAEVTPVVLIEAGIV
                     KAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITAKGGSVEVI"
     gene            complement(10298..10480)
                     /gene="rpmD"
                     /locus_tag="AC0DU4_001469"
     CDS             complement(10298..10480)
                     /gene="rpmD"
                     /locus_tag="AC0DU4_001469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HIN4237416.1"
                     /translation="MAQIKITLTKSPIGRIPSQRKTVVALGLGKLNSSVIKEDNAAIR
                     GMITAVSHLVTVEEVN"
     gene            complement(10494..10988)
                     /gene="rpsE"
                     /locus_tag="AC0DU4_001470"
     CDS             complement(10494..10988)
                     /gene="rpsE"
                     /locus_tag="AC0DU4_001470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HIN4237417.1"
                     /translation="MAFKDNAVELEERVVAVNRVTKVVKGGRRLRFAALVVVGDHNGR
                     VGFGTGKAQEVPEAIRKAVDDAKKNLIEVPMVGTTIPHEVLSEFGGAKVLLKPAVEGS
                     GVAAGGAVRAVVELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEIAALRGISV
                     SDLA"
     gene            complement(11006..11362)
                     /gene="rplR"
                     /locus_tag="AC0DU4_001471"
     CDS             complement(11006..11362)
                     /gene="rplR"
                     /locus_tag="AC0DU4_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HIN4237418.1"
                     /translation="MISKPDKNKLRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQV
                     IDDVAGVTLASASTLDKEVSKGTKTEQAVAVGKLVAERANAKGISEVVFDRGGYLYHG
                     RVKALADAARENGLKF"
     gene            complement(11446..11982)
                     /gene="rplF"
                     /locus_tag="AC0DU4_001472"
     CDS             complement(11446..11982)
                     /gene="rplF"
                     /locus_tag="AC0DU4_001472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_function: GO:0019843 - rRNA binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HIN4237419.1"
                     /translation="MSRIGNKVIVLPAGVELANNDNVVTVKGPKGELTREFSKDIEIR
                     VEGTEITLHRPNDSKEMKTIHGTTRALLNNMVVGVSEGFKKELEMRGVGYRAQLQGSK
                     LVLAVGKSHPDEVEAPEGITFELPNPTTIVVSGISKEVVGQTAAYVRSLRSPEPYKGK
                     GIRYVGEFVRRKEGKTGK"
     gene            complement(12174..12572)
                     /gene="rpsH"
                     /locus_tag="AC0DU4_001473"
     CDS             complement(12174..12572)
                     /gene="rpsH"
                     /locus_tag="AC0DU4_001473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009754342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HIN4237420.1"
                     /translation="MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIAEILKREG
                     FVKNVEIIEDDKQGVIRVFLKYGPNGEKVITNLKRVSKPGLRVYKKREDLPKVLNGLG
                     IAILSTSEGLLTDKEARQKNVGGEVIAYVW"
     gene            complement(12857..13126)
                     /gene="rpsN"
                     /locus_tag="AC0DU4_001474"
     CDS             complement(12857..13126)
                     /gene="rpsN"
                     /locus_tag="AC0DU4_001474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S14"
                     /protein_id="HIN4237421.1"
                     /translation="MAKKSMVAREAKRQKIVDRYAEKRAALKAAGDYEGLSKLPRNAS
                     PTRLHNRCRVTGRPHSVYRKFGLSRIAFRELAHKGQIPGVTKASW"
     gene            complement(13144..>13311)
                     /gene="rplE"
                     /locus_tag="AC0DU4_001475"
     CDS             complement(13144..>13311)
                     /gene="rplE"
                     /locus_tag="AC0DU4_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376779.1"
                     /note="part of 50S and 5S/L5/L18/L25 subcomplex; contacts
                     5S rRNA and P site tRNA; forms a bridge to the 30S subunit
                     in the ribosome by binding to S13; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HIN4237422.1"
                     /translation="RGNYTLGVKEQLIFPEINFDDVDKTRGLDIVIVTTANTDEESRA
                     LLTGLGMPFAK"
BASE COUNT         3873 a         2971 c         2364 g         4103 t
ORIGIN      
        1 atgagtttgt ggcaaccttt atcggacgca caaatattat ccctgccaat cttgaaaaac
       61 ggagcgacgg cgcttatatc gtcttttcag atggctatgc ccttcgaatg ctagctcttg
      121 atcaggttga ggagcaagct attcatgtaa gcattcgtcc cgaagagttt atcaaagatg
      181 aatctggaga tattgaagga actattagcg atagcgtcta tcttggacta aatacggagt
      241 atttcattga gacaggtttt gcctcaaaaa ttcaagttag tgaagaatca acttttgaag
      301 aagatctaca aaaaggcaat cgtattcgtc tacgaatcaa tacgcaaaaa ttaaacatct
      361 tttctgcaga tggttcccaa aacctgataa aaggagtcaa ccatggaacg taaaaaacta
      421 aatatttgga cagcctcctc tttcttcatc tttcttacct atcttgtctt tctcgtttat
      481 cctatcgtta ccgtgctcaa gtaagcactt atacatgaag gacaattctc actagctaat
      541 tttgtcactt tctttagtaa agtctactac tctgagacac tagtcaacag tttcaaggtt
      601 tccattaccg ctactgtcac ttccttagtt gtaggaaccc tattagctta tctcttctct
      661 atgtatgact tcaaggggga gaaatttcta caaatattga ttatcattgc ttccatgtca
      721 gctcctttcg taggagccta ctcctgggtt ctcttgctag gacgaaatgg ggtcatcact
      781 aaatttttga caaatgccct tcatcttcca gctatcgata tttatggatt caaaggaatt
      841 gtacttgtct ttacactgca actattccca ctggtatttc tatatgttgc tggaacaatg
      901 aacagtattg acaattctct acttgaagca gctgaaagca tggggtcctt cggatttaag
      961 cgtatcgtaa cggttgtttt acctctccta gttccaacct tactagcagt tccttgcttg
     1021 tatttatgag agcattctca gactttggaa cgcctatgtt gattggcgaa ggatatcgga
     1081 ctttccctgt cctgatttat acccaattta ttagcgaggt tggaggaaat tctgcttttg
     1141 caattatggc gattatcatt gccttggcga ttttccttat ccaaaaacac attgcaaacc
     1201 gctacagttt cagcatgaat ctgctccatc caattgagcc taaaaaaact acaaaaggaa
     1261 aaatagctgc catttatgca acagtctacg gaattatctt tatctctgtt ttacctcaaa
     1321 tctacttaat ttatacctct ttcctaaaaa catcaggtat ggtatctgtt aaaggttatt
     1381 ctccaaacag ttacaaggta gctttccatc gtatgggatc tgctattttc aataccattc
     1441 gtatcccttt gattgcctta gttctagttg ttctatttgc gacatttatc tcctacctag
     1501 ccgttagaaa acggaatttg tttacaaact taattgacag cctcagtatg gtaccttata
     1561 ttgtaccagg aaccgttcta gggattgcct tcatttcttc cttcaatact ggtctatttg
     1621 gaagtggatt tcttatgatt acagggactg ctttcatctt gattatgtct ctatctgtca
     1681 gaagattacc ttatactatt cgctcatctg ttgctagctt acaacaaata gcaccaagta
     1741 ttgaagaagc tgctgaaagc ttaggaagta gtcgtctcaa tacctttgct aagattacaa
     1801 ctccaatgat gctatctggt atcatttctg gagccatctt atcttgggtc acaatgattt
     1861 caaaactctc tacttctatc ctcctctaca atgtcaaaac aagaacaatg actgtagcta
     1921 tttatacaga ggttctcaga ggaaattacg gtgtagccgc agccttgtca actatcctga
     1981 ctgttctaac agtaggttcc ttgctcttgt ttatgaaaat ctctaaaagc aatagcatta
     2041 cactttagtt ttccacatca aaaacagccg aaaggagtac cctcggctgt tttttcttat
     2101 cttgatattc ttatcaaatc cctagctcat ggcaagcaag tctagactga ttaaatagag
     2161 ccttcttcca tcttctcacg tcctagctct cggtaactac ggtcaccgac aacttcaacc
     2221 ctaaactgac cgtcctcata ttcaagaatc gtcacgctac cattatctag accatgcgga
     2281 tgcatgccat taatcagata aacaatggtt ccaatagtca ttccatggct gacaacaagg
     2341 gcgttacctc caccttgatc ttccatttct tttgcaatca tttcaaagcc ttccttgatt
     2401 cggccactga gtttttccca gccttcagcc caaccagctg tatcgacctc taccaagccc
     2461 tcagccagtt cagcataaga caattggtga acgtggtcca cattaaagat acgaggaata
     2521 atgcccatga aaagatcgcc atcataggct ccatcaaaac taccgaaaca ccattctctg
     2581 atacgcttgt ccatgcgata agggattttc ccctgcaagc caagttcttc aaggataatt
     2641 cccatggtct gaatggtacg accagaatca ctcgaataag cgcgctcaaa ctgtagatca
     2701 gattctcgca aaccgattcc taactcttga atccctcgtt caccttcagc agttaaggga
     2761 gtatcgctcc aaccttgcgc gcgaccaatc gtgttaaaca tggtcttgcc atgacgtacc
     2821 aaatacaatc gtacttttac cattttccgt cctccgtttg cttctattat atcatgaatg
     2881 ataaaataaa agccacccat acaggcgact tttgaaggag attattatga aaaagtttag
     2941 gagttcatta aataaagata ttagatgaaa atcaaattca aactaattca gtgttatctg
     3001 tttcaaataa tattaggagg tctttattta atgattatag tatacacgtc taatcttaaa
     3061 tagaacttaa aatttctcct attttcttaa tttttaaaac tatgaattgg tgctgggatt
     3121 tgtccaccgc gagagatgaa gtcgacagac gaagccccat taaccttcat aacaggtgca
     3181 gttcctaata gaccaccaaa ctcaatcata tcgccttctc ttcctttggg aatgatacga
     3241 acagctgttg ttttcatgtt gataacaccg attgctgctt catccgcaat catagccgca
     3301 atggtttcag caggcgtatc ttctgggatg gcaatcatat ccaatccaac agaacagata
     3361 gccgtcatag cttctagttt ttctaaatta agagagccat tttgcactgc agcaatcatt
     3421 ccttcatcct cagaaacagg gataaaggca ccagataaac caccgacttg gttgcaggcc
     3481 atcactccac cctttttaac ttggtcgttc aagagggcca aggcagccgt cgttccatgc
     3541 gtgccaactg tttctagccc catttcctca aggacacgtg ccacagagtc tccaaccgca
     3601 ggggttggtg ccaaactcaa gtccacaata ccaaactcca cacccagtct ctcactggcc
     3661 atttgaccaa ccaattgacc gatacgagtg attttaaagg cagttttctt aactgtttcg
     3721 gctactacat caaagctctg tccacgaact ttttccaaag cacgtttcac aacaccagga
     3781 ccagaaactc cgacattgat gataacatct gcttccccaa caccatgaaa ggcacccgcc
     3841 ataaatggat tgtcctcaac agcattagcg aatacaacca acttggccac tcccatatct
     3901 gaaagatttg ctgtttcctt gataattcgt cccatatctg ccacagccgt catattaata
     3961 ccagacttgg ttgagccgat attgactgac gagcagacct tatccgtctc agccaaagcg
     4021 cgaggaatgg aattgatgag aatctcatct cccttttgat aacctttttg tactaaggca
     4081 gaaaaaccac caataaagtc cacaccaatc tctttcgcag ccttatcaag cgcttttgcc
     4141 agaaccacgt agtccgtcgc atctgtcgct gccccaatca gagaaatagg tgtcaccgat
     4201 acacgcttat taacgatagg aattcccaac tcagccgcaa tttcatcacc aacagctact
     4261 aaattagccg cctttgtcgt aattttttga tagattttct ccgcagcacg attgatattt
     4321 ggatcgatac agtccaaaag agaaatcccc atggtaatgg ttctaatatc gaagttttgc
     4381 tcctcaatca tggcgatggt ttcagtaact tgtctaatat ccatgatgac ctcctagata
     4441 ttatacatag cttcgaaaat cgctgcactc tgaatattga tttttacatt caaagtttgc
     4501 ccaaaagctt caaattcatt acgaagatag gtaaaatctt gcttttcatc actagataca
     4561 acagccatca tcgtaaaata ttcatccaag acagtttgag agatatcgtc aatattcaat
     4621 cctaattctg caattttacc agaaacacct gcaacaattc cagatttatc tttaccaaca
     4681 acagttataa tggctttcat aagtaaactc caattcttct taaaataaga aaccttaaca
     4741 ttaaacagga ttcttttcaa atagtatagc ataattctaa cgaaaatact caaaaacgcc
     4801 tgcttacgaa gttgttctta agaaaaaaac aatttcgtaa acaagcgtct actatcccaa
     4861 cttatgatga gtgttcccgc taggaccgaa atcctagcgg tagaccagag ctagactaag
     4921 agcacaagac tccatcatca taacactcaa caaaattgat gattttatac taattcgatg
     4981 atcgccattg gcgctgcatc accacgacgt ggttcagttt taaggatacg agtgtatcca
     5041 ccgttacgtt cagcataacg aggtgcgatt tctgagaaca atttttgaag tgctgtagta
     5101 gaagtgtact tatcagttgc ttcatcatag ttttcagatg cgatttcatt acgtacgaaa
     5161 gcagctgctt gacgacgtgc atgcaaatca ccacgtttac ctagagtaat cattttttca
     5221 acagttttac ggatttcttt agcacgagct tcagttgtca cgattgattc gttgatcaaa
     5281 aggtcagttg tcaaatcgcg aagcattgct ttacgttgtg agctagtgcg tcctagttta
     5341 cggtaagcca tgtattcctc ctttatttat cttttaatcc aagacccaaa tcaatgagtt
     5401 tgagtttcac ttcttccaaa ctcttgcgtc caagatttcg tactttcatc atctctgctt
     5461 cagatttttc tgtcaaatca tgcacagtat tgataccggc acgttttaaa cagttgtatg
     5521 aacgcacaga caaatccagt tcctcaatcg tacgatctaa aatacggtcg tcagattcag
     5581 tatcagcttc tttcatcact tcagttgact tagcaatctc agtaagattt gtaaacaaat
     5641 caagatgttc tgtcaaaata cgtgctgaaa gccctaaagc atcttctgga ataattgttc
     5701 catttgtcaa gatttcaagg gttaatttgt cgaaaccatc attgctacct acacgagcag
     5761 gttccacttg atagttgact tttgtaactg gtgtataaat agaatctaca gcaagtgttc
     5821 caactggtgc attatccttt ttattttcat cagcaggtac atatccacga ccactgttaa
     5881 cagtcatagt cgcttttaga gaagaacctt caccaattgt aaagagataa tgatctggat
     5941 ttacaatttc aatatcgcta tctgtcaaaa tgtcaccagc tgttacttca gcaggacctt
     6001 caacatccag ttcgatgatt ttttcgtctt caacgtacga tttcactgca attcctttaa
     6061 tgttcagaat gatttgcatc acgtcttcac gaacacctgg aactgtgtca aactcatgta
     6121 acacaccatc aatgttgata gatgtcacag ctgctcctgg tagagaagct agaagtacac
     6181 gacgaagaga gttaccaaga gttgtaccgt agccacgttc aagtggttcg attacaaact
     6241 tgccataatc tttattttca tcaatttttg ttatatttgg tttttcaaac tcgatcattt
     6301 agttactccc tcttaaacga aaagcagtgt aatgcgatga ttatacacgg cgacgttttg
     6361 gaggacgagc accattgtgt ggcactggag tcacatcacg aattgctgtt acttcaagac
     6421 cagcggcagc aagcgcacga atagctgact cacgaccaga acctggacct tttacagtaa
     6481 cttcaactga tttaagaccg tgttcttgtg cagatttagc agcagcttca gaagccattt
     6541 gagcagcgaa tggtgtagat ttacgagaac ctttgaaacc aagagcacca gctgatgacc
     6601 aagcaattgc attaccatgc acatcagtaa tcataacaat agtgttatta aatgtagcgt
     6661 gaatatgagc aataccagat tcgatattct ttttcacacg acgtttacgt gttggtttag
     6721 ccaagacttt tacctcctat attatttttt cttaccagca atcgcaacag ctttaccttt
     6781 acgagtgcga gcgttgtttt tagtgttttg tccacggaca ggaagtccac gacggtgacg
     6841 gataccacgg tatgaaccga tttccatcaa acgtttgatg ttcaagttta cttcacgacg
     6901 aaggtcacct tcaactttga ttgcatccac ttcacgacgg atagcatctt cttgatctga
     6961 tgtaagatca cgtacacgaa catcttctga gattccagca gcagccaaaa ttttcttaga
     7021 tgttgcaagt ccgataccat aaacataagt caatgagatt actacgcgtt tgtcatttgg
     7081 aatatcaact ccagcaatac gagccatgtt ttctcctttc tatcttatcc ttgacgttgt
     7141 ttgtgttttg gatttgctgg gcaaattacc ataacacgac cattacgacg aataacttta
     7201 cagtattcgc aaattggttt gaccgatggt cttactttca tttcttatcc ctccaagttt
     7261 ttcgattatt taaagcggta agtgatacgt ccacgtgtca agtcatatgg actcatttcg
     7321 acagtaacac gatctcccgc taaaatacga atatagtttt tacgaatttt accagaaact
     7381 gttgctaaaa tctgatgtcc attttcaagt tcaaccgtaa acattgcatt cggcattgta
     7441 tcaactactt tgccttcaac ttcaatcaca tcgtcttttg ccacgcaaaa gcacctccat
     7501 aaatttcgat tcgatgcctc tagacacaga gacaacaatt ataagtcaga ctatctcagt
     7561 ataacatttg tagcggattt tggcaagtgt gaaaaacgct ttatttcaaa tttgtcaata
     7621 ctttttcaat atctgagaag acatcattga tatcttgatt accttcgatg tcatgaacca
     7681 aacctttggc acggtagtga gcaatgattg gttctccttg agcaatatta acatccaaac
     7741 gacgttttac tgtctcaggc ttatcatctt cacgttggta gtaatcttct tctttatagt
     7801 caactggtgg gttaaagacc ttgtggaaag tttctccagt tacgcggtgg atgatacggc
     7861 cactcaaacg ttccaaaagg ctgtcagggt tcacttcaat attgataaca ccttctagtt
     7921 caatgccaag ttcagtcaat gttttgtcca aggcatgagc ttgttcaatt gtacgtgggt
     7981 aaccatccaa taagaatcct gtttctttaa tatcatcttg tgaaagacgt tcttttacga
     8041 ttccatttgt aacttcgtca ggaaccaatt cacccttgtc aatatatgac ttagcaagaa
     8101 cacccatttc agtttgattt gccattgcag cgcggaacat atcacctgtt gagatatgtg
     8161 caacatggaa ttgttctacg atttttgctg cttgagttcc cttacctgca ccaggtaagc
     8221 ccataatcaa aagattcatg atttgatctc cttattttat ttttaaatag aagcaaaaag
     8281 tcttttcacc cctatttaaa aacaaaatag aagaggggag atccaactct tacaaatgtc
     8341 agagtttaaa cctccactcc ctcagcattt actgattcag taaatacttt tattctgttc
     8401 tgtccatgaa accaacatac ttacgtttca ataggtaacc ttccaattgc ttgattcctt
     8461 cgatacctgt agagataatg atcaagagac ttgttccacc aaaggcaaca acatcagaaa
     8521 gaccaaatac atctttagct gcaatcggta aaatggaaat cacaccaagg aagagggaac
     8581 caacagttgc aagacgacga agaagtttag acatatattc ttctgtacct ttaccaggac
     8641 gaactccatg gatataggca ccactctttt gtaggctctc tgctgctttt tcaggattaa
     8701 tctgtacaaa cgtatagaag aatgtaaaga gaataatcaa caaagcatac atggcaatac
     8761 cagttggaga agtagttgcc agcatctctt gtgctaccct tacccaagcc caatcatgac
     8821 ctgtggcact caaaaactga agaatagccg caggcgctgc agtaatcgaa ctggcaaaga
     8881 taacagggat aactccagca gggtttacct ttaacggaag gtaagagcta gatggagcac
     8941 cttgtgcaac cttagtatat tggattggaa ttttgtattc tgcttgttga acataagttg
     9001 taaagtaaat aatcaacaat acagtaataa tcaaaatgat tacgaaaatg atagatgaag
     9061 tgatacggct acttgggacg ttcacaaagt agtccacata gatgccctga atcatctctg
     9121 gaattgagga aacaatcccg gcaaagataa tcatggaaac accgtttccg tatcccttat
     9181 ctgtaatttg ctcacccaac caagtgacaa tcatactacc agctgttaag atgataccaa
     9241 tcgtcagaaa aacttgtgga gttaaagcag ttttaatcaa ttgagctcca gccaaggtat
     9301 taaaaccagc tgtaatcccg atagattgca caaaagcgag aactagagca atataacgag
     9361 tagcttgatt caattttctt cgacctactt ccccttgttt accccactct acaaacttgg
     9421 gtaaaatatc catttgcaag agttggacaa caatagaagc ggtgatatag ggactaactc
     9481 ctagggcaaa aatcgaaaag ttttttaggg cattccccga caccaagctc aacatgttta
     9541 agaaggataa tccacttaaa gcattcaagc tattggcatt cacaccagga actgtaatgc
     9601 tagttccgat acgaaagacc aaaacgataa aaattgtaaa taaaattttt gatcgaacct
     9661 gcttgacttt aagagcttct cttaataatt taaaaaacat aggtcacctc tcttagatga
     9721 cttctactga accaccttta gcagtgatag cttcttcagc tgatttagag aatttagctg
     9781 ctttcacagt caatttctta gtcaactcac cgttaccaag aattttaata cctgactttt
     9841 cagctttaac aattcctgct tcgataagaa caactggagt tacttcagca ccatcttcaa
     9901 agacgttcaa ttggtcaagg ttcacaattg cgtattcttt agcgttgatg ttagtgaatc
     9961 cacgttttgg aagacgacgg aacaatggag tttgtccacc ttcaaaacca aggcgaactc
    10021 cgccaccgct acgagctttt tgaccttttt gaccacgacc agatgtttta ccgttacctg
    10081 atgaagtacc acgaccaacg cggttacgta ctttacgaga accttctgca ggtttcaatt
    10141 catgaagttt catttttatt ttctcctctt ttgtaaaatg ctagcgccga taagggagaa
    10201 aaggttgtct cccccatcaa ctcgcctata cgatgtcatc atagatgact atatctagtt
    10261 ttaggggatg gtacagtgca catcccctaa aacttcatta gtttacttct tcaactgtta
    10321 ctaagtgaga tactgctgta atcataccac ggatagcagc gttatcttct ttaataacag
    10381 agctgttcaa tttgccaagt ccaagtgcta caacagtttt acgttgtgat ggaatgcgtc
    10441 cgattggaga cttagtcaaa gtaattttaa tttgagccat tttatcccct ttcttatgcc
    10501 aaatcagaaa ctgaaatacc acgaagggca gcaatttctt cagcgcgttt caattgtttc
    10561 aaaccttcaa cagttgcacg aacaatgttg attggagtgt tagaaccaag tgatttagat
    10621 gtaatatctg ccacacctgc caattccaca acggcacgaa ctgcaccacc agcggcaact
    10681 ccagaacctt ctacagcagg tttcaacaat actttagctc caccgaattc tgaaagaact
    10741 tcgtgtggga ttgttgttcc aaccatagga acttcgatca agtttttctt agcatcatct
    10801 actgctttac ggattgcttc tggaacttct tgagctttac cagtaccaaa tcctacgcga
    10861 ccattgtggt caccaacaac aacaagagct gcgaaacgaa gacgacgtcc acctttaaca
    10921 acttttgtaa cacggttgac agcaactacg cgttcttcta attcaactgc attgtcttta
    10981 aatgccattt tctagtgtcc tcctattaga atttcaatcc gttttcacga gctgcatcag
    11041 ccaaagcttt cacacgtccg tgatatagat atccaccgcg gtcgaacacc acttctgaaa
    11101 tacctttagc gtttgcacgt tctgcaacga gtttaccgac agcaacggct tgttcagttt
    11161 tagttccttt tgaaacttct ttatcaagag ttgaagcact tgcgagcgtt acacccgcta
    11221 cgtcatcaat cacttgagcg tagatgcctg tattagaacg gaatacgttc aaacgtgggc
    11281 gatcagcagt tccagagagt tttccgcgaa cgcgacggtg gcgtttttgg cggagtttgt
    11341 ttttatctgg ttttgaaatc acagttttca cctctttagt tttaaatcgt gtgctatgca
    11401 caaagttgga aaataggttg gtggttgatg atcaaccact caacattatt tacctgtttt
    11461 accttcttta cggcgaacga attcaccaac gtaacggata cctttacctt tatatggttc
    11521 tggtgaacga aggctacgta cgtaagcagc tgtttgacca actacttctt ttgaaattcc
    11581 gctaacaacg attgttgttg ggtttggaag ttcaaaagta attccttctg gagcttcaac
    11641 ttcgtctgga tgagatttac caacagccaa aacaagttta gatccttgaa gctgtgcacg
    11701 gtaaccaacc ccacgcattt caagttcttt cttgaatcct tctgatacac caacaaccat
    11761 gttgttcaaa agggcacgag tagttccgtg gatagttttc atttcttttg aatcgtttgg
    11821 acggtgaaga gttatttcag taccttccac acggatttca atatcttttg agaactcacg
    11881 agtaagttct cctttaggtc cttttacagt tacaacgttg tcattgttag cgagttcaac
    11941 accagcaggc aacacgataa ctttattacc aatacgtgac atgtttattt tctcctgtta
    12001 aattgtcagg ccagaacggc cagttttcac ggggttcaga tacttattta gttcaagagc
    12061 tgaactgaac acgctctaag aactgtgcaa aatagataag ttggcttgtt tgtaaacaaa
    12121 cttctccaac ttcctaattt tgctttgttc tttacgagct ttgtatcttg attttaccaa
    12181 acgtaagcga taacctcacc accaacattc ttttggcgtg cttctttatc agtaagcaaa
    12241 ccttcagaag ttgaaaggat ggcaattcca agtccgttaa gaacttttgg aaggtcttca
    12301 cgttttttgt agacacgaag tcctggttta gaaacacgtt tcaagttagt gataactttc
    12361 tcaccatttg gtccgtattt aagaaataca cggatgacgc cttgtttgtc atcttcaatg
    12421 atttcaacgt tttttacaaa accttcgcgt ttaaggattt cagcaatccc ttttttgatg
    12481 tttgatgcag gtacttcaag tacttcgtgt ttagcttggt tagcattacg aatacgagtt
    12541 aggaagtctg cgattgggtc agtcataacc attttgtttt tctcctctta ctagtagttt
    12601 gcaagttgca cttgctagtt aatacatgat acaaagagcg taacagcacg agcaaaaata
    12661 gacaatttaa tgcagaagca atgctccaaa gcaaattagt cttttttgcc aaagctgtag
    12721 ctcgtgttca aattggcaag cccaattgaa cccgggctaa actctgtgtg aaaaagataa
    12781 actttcctag aaactttagt ttcttcgtca agtttcctat ttttacttgg agttttgacg
    12841 ctcttgatat cttaaattac caagatgctt ttgttacacc aggaatttga cctttatgcg
    12901 caagttcgcg aaaagcgata cgactcagac caaatttgcg gtaaactgaa tgtgggcgcc
    12961 ccgtaaccct acaacgatta tgtaaacgag tcggtgaggc gttgcgaggt aatttagata
    13021 aaccttcgta gtcccctgcc gcctttaatg cagcacgttt ttcagcataa cggtcaacaa
    13081 ttttttggcg tttagcctct ctagctacca ttgatttttt agccattaga tttacctcct
    13141 atattatttt gcaaaaggca ttccaaggcc tgtaagcaat gcacgtgact cttcgtcagt
    13201 gttagcagtt gttacgataa cgatgtcaag accacgagtt ttgtcaacgt catcgaagtt
    13261 gatttctggg aagattaatt gttctttcac accaagtgtg tagttcccgc g
//
LOCUS       DBMVGT010000046        13112 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.046, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000046 DBMVGT010000000
VERSION     DBMVGT010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 13112)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13112)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13112
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.046"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            397..735
                     /locus_tag="AC0DU4_001476"
     CDS             397..735
                     /locus_tag="AC0DU4_001476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="HIN4237423.1"
                     /translation="MLKKYPCTMQHDQSDCAAAVVSTVLLSYKKELSIMKIREIIGTD
                     MYGTTVSGIVSGLNKLNFTVKAVRVALEDLTPKLTFPAILQVKNDLGQNHFVVLHSIK
                     EKINGTRITK"
     gene            832..1209
                     /locus_tag="AC0DU4_001477"
     CDS             832..1209
                     /locus_tag="AC0DU4_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237424.1"
                     /translation="MSPGTFIALTGAAVLTKKLINYIKVGGLGGWLIGAAAGVLALIF
                     LIKICVDTTIKVLLNRIFKASKVMKRRIFSLFVLDLMVYIFLGYVLVIQKDVYLFSIL
                     IIFSNFSVPFIREKEYELFKNKK"
     gene            1363..1575
                     /locus_tag="AC0DU4_001478"
     CDS             1363..1575
                     /locus_tag="AC0DU4_001478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000973716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237425.1"
                     /translation="MLIVLISVIVALLYHKITEYVNNRKIDIVIFLSLLISHFIWNYY
                     FLPIEILIAISGANLLLSFLKKLQTK"
     gene            1949..2074
                     /locus_tag="AC0DU4_001479"
     CDS             1949..2074
                     /locus_tag="AC0DU4_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237426.1"
                     /translation="MATITNALNIAATVAEVFSLGGAIAYGLDIVDGKFDGYLWA"
     gene            2055..2300
                     /locus_tag="AC0DU4_001480"
     CDS             2055..2300
                     /locus_tag="AC0DU4_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000513491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237427.1"
                     /translation="MGIYGRKTIAMKHFFAGIGEIHFLLFLLYLSMSASPIIGLVIGY
                     TKINLINSIIIALGMILALILVLSRVYRKYFYRDDDD"
     gene            2457..3515
                     /locus_tag="AC0DU4_001481"
     CDS             2457..3515
                     /locus_tag="AC0DU4_001481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237428.1"
                     /translation="MKDDQKYLLAGLYSLLVAIFYFPLIDSKGIFVSILMAVLLLYLI
                     YFIATVIHIVIIKFIRKKSFKYLVLYPFTYDGSWRFQPINLLYFPEMVRDVIPINLVQ
                     EYCQGQPYGLLKKMLKRIRLSREISLLLATIIVYFFTHRILPFSVFTFMFSYILLFVQ
                     SYLGGNTAWIGNRRLIIDDEFEKILLSKSYIKEISSARYSEYLTCEYKNFTPIILLAI
                     FENLLDSYLLQNQSEVDLDIFYKVLPLLYKEKYTMGFNYFVSLNYLLYKVGFLGIIYD
                     NEALRDLSKQYLNKNISELQDGSFEGGIQDAVASKQIVVINEFIACLNSRCMPSQYDR
                     FFYKDRPYIFSRKSPIKG"
     gene            3830..4807
                     /locus_tag="AC0DU4_001482"
     CDS             3830..4807
                     /locus_tag="AC0DU4_001482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237429.1"
                     /translation="MKNKRYFFDTILIILLLISTIFCVSPVFIKLDILGTPSHAILTF
                     VLAIPLFYILSQCLHTLLLLVSSIFCKLRPIYFYFIFVIIIGARKYYRILFHQLMGFS
                     PGIAVFYKESQTTKNLFKFYYFLYFTTLISYYFFFTFVYDKPLLLPLISFSIIIALVQ
                     KLYRIENQQLFLLKSKVLTILESKKNCEFNLQDYHEIWKLQSKSELPCVALSYISLIK
                     PYLSESVREQIDLLEVKRFKKINNPISLYGMLDVIKLNLYLRHYNEKNKYESMLKKIL
                     EVRPDFVLIEQNIDDSLNSSQPLSLSLAISEIQLLLEVYIGIKHVSIRR"
     gene            5184..5558
                     /locus_tag="AC0DU4_001483"
     CDS             5184..5558
                     /locus_tag="AC0DU4_001483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424474.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPH_0224 family bacteriocin-like peptide"
                     /protein_id="HIN4237430.1"
                     /translation="MELVLPNNYVALEQEEMMYLDGGFSILRWPVATAINIAFNGVLG
                     GGAISLVRNYIRNYGLRRVTSAIAGAAARYVGVRVANRVAGFALSAINGFAAWMSIGD
                     AITTIWANNDVNRRDPNLNALW"
     gene            5565..5747
                     /locus_tag="AC0DU4_001484"
     CDS             5565..5747
                     /locus_tag="AC0DU4_001484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000511668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237431.1"
                     /translation="MGIKMEKIFVIIFFVCLFISSITFLAYDFVSEEIKKLIIWMNVV
                     FLILIIAMIIYPKLRK"
     gene            5766..6668
                     /locus_tag="AC0DU4_001485"
     CDS             5766..6668
                     /locus_tag="AC0DU4_001485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237432.1"
                     /translation="MIRKLIIFLLMLPLFVLWLELHLLVSNLQLNLEIPLDFVVSTSL
                     AFCSLILSKIVLDILYALKDLYKKEALITIFPFIFIGRKKVNVRFSPYFSFHRKSLSP
                     DDLRSRIIWSFILEIAIILVFILKIPFAIIMLTTIFFWTIMDINHLVFNKTEFLFNQN
                     KWEKEDSFESDLTKTLKDKIQKSELSYSDLMSLQLYDAMNQSTFLTDSELFEDILKKI
                     EDSHNTLLCTGLVELLLYEMSISNNNNWSNKVDKIRIHLIRINQLDFFYYTSWLRQNF
                     DFCMNREYHKMKSRKLLLSNKKIV"
     gene            6724..7056
                     /locus_tag="AC0DU4_001486"
     CDS             6724..7056
                     /locus_tag="AC0DU4_001486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HIN4237433.1"
                     /translation="MELVLPNNYVVIDEEEMMYLDGGAYLSKRACQGICVALAMSSGT
                     FIALAGAAVLTKKLINYIKVGGLGGWLIGAAAGKIAYCIGYGALNRGCDISGNPYPWD
                     GFISATVR"
     gene            7053..7781
                     /locus_tag="AC0DU4_001487"
     CDS             7053..7781
                     /locus_tag="AC0DU4_001487"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237434.1"
                     /translation="MNNVDKIRKIHIIVCWVYIFLSFRAIINDTEYFLLIFLAFIYSI
                     VSLPLYSVKNKIVSICLAINSILLMSFPILINKFFPESFLTYTVLISVFILELAIFHL
                     IGEDFATKLTNEYKKISQFRSKVSQSSWIKYLEISSFILTIFPSILYGTVDNRVLALI
                     FLIKICVDTTIKFLFIRLFDTSTLMKRRIFFLFALDVIAYLFLGYLLVIQKAGYLFSV
                     LLLFSNFSVPFIKAKEYELFKNSK"
     gene            8260..8457
                     /locus_tag="AC0DU4_001488"
     CDS             8260..8457
                     /locus_tag="AC0DU4_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237435.1"
                     /translation="MKHFFAGIGEIKLVGYLLYICVGLALLFHIYVIGSELSFVKIVL
                     SILGVIFVSMLTIARIYRTFL"
     gene            8914..9153
                     /locus_tag="AC0DU4_001489"
     CDS             8914..9153
                     /locus_tag="AC0DU4_001489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237436.1"
                     /translation="MKLLDCILDYQERFNGKTCQVSTNYKYLEIFKVNFCLTDLHHLF
                     DLYKITRDYASQTKPAIQAGVFILEDFRNILCTMM"
     gene            9138..9416
                     /locus_tag="AC0DU4_001490"
     CDS             9138..9416
                     /locus_tag="AC0DU4_001490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237437.1"
                     /translation="MYNDVIERISLYEFIGDIFYSKIISCCIVARDLSKNTMKLDVIF
                     FEDKNKRSAVLGLRRDKSGVFKSVTLHFTSAKKYAKVRKTDVKEMKWL"
     gene            9705..11513
                     /gene="pspA"
                     /locus_tag="AC0DU4_001491"
     CDS             9705..11513
                     /gene="pspA"
                     /locus_tag="AC0DU4_001491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein A"
                     /protein_id="HIN4237438.1"
                     /translation="MNKKKMILTSLASVAILGAGFVASQPTVVRAEEAPVAKQSQAER
                     DYDAAMKKSEAAKKEYEEAKKDLEEAKAAQKKYEDDQKKTEEKAKLVQKADEERQKAN
                     VAVQKAYLKLREAQEQLNKSPNNKKNAAQQKLKDALAHIDEVTLKQKEAEANFNKEQA
                     KVVPEADKLAETKKKAEQAEKKEPELAKKVAEAKAKAEEAEKKAVEAKQKVDAEKYAL
                     EAKIAELEYEVQGLEKELKEIDESDSEDYIKEGLRAPLQSKLDAKKAKLSKLEELSDK
                     IDELDAEIAKLEKDVEDFKNSDGEQAEQYLVAAKKDLDAKKAELENTEADLKKAVDEP
                     ETPAPAPKPAPAPAPTPTPEAPAPAPKPAPAPKPAPAPKPAPAPKPETPKTGWKQENG
                     MWYFYNTDGSMATGWLQNNGSWYYLNANGAMATGWAKVNGLWYYLNSNGAMATGWLQY
                     NDSWYYLNTNGAMATGWLEYNGSWYYLNANGAMATGWLEYNGSWYYLNSNGAMATGWL
                     QYNGSWYYLNANGAMATGWAKVNGSWYYLNANGSMATGWVKDGDTWYYLEASGAMKAN
                     QWFKVSDKWYYVNGLGALAVNTTVDGYTVNENGEWV"
     gene            11914..13035
                     /gene="mnmA"
                     /locus_tag="AC0DU4_001492"
     CDS             11914..13035
                     /gene="mnmA"
                     /locus_tag="AC0DU4_001492"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_function: GO:0016783 - sulfurtransferase activity
                     [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HIN4237439.1"
                     /translation="MSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDT
                     DENGVCTATEDYKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVM
                     CNKEIKFKAFLDYAITLGADYVATGHYARVARDEDGTVHMLRGVDNGKDQTYFLSQLS
                     QEQLQKTMFPLGHLKKPEVRKLAEEAGLSTAKKKDSTGICFIGEKNFKNFLSNYLPAQ
                     PGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQ
                     GFYHDSLMSTSLEASQVHFTREMPEEFTLECTAKFRYRQPDSKVTVHVKGDKAEVIFA
                     EPQRAITPGQAVVFYDGEECLGGGLIDNAYRDGQVCQYI"
BASE COUNT         4393 a         1845 c         2551 g         4323 t
ORIGIN      
        1 tgtaaaaagt aaaaaagaaa gtcgaaataa atttgtgaaa aaagttaacg taattttaaa
       61 atgagcttaa taagaggtat gatgtaggta gaaaataaag ataggagaaa aagtatgaat
      121 aaaaaaatat tttgtattct agtatgtatg atatcattga ttagtctggt cataatcttt
      181 ccatggggct ggtcgatata atgtaaggga gcttgagttg ttaaaggagg ctcagtcctt
      241 ggacaaaaat ctgctgtact acaatgcttg gaaagatatc aagaacaaag aatgatacga
      301 ttgaaaataa actgattcaa gaactactgg gcagtgattg aggtttgggt gacatcaaag
      361 aaaagttaga ttaattctaa agaattgagt atttctatgt taaaaaaata tccttgtacg
      421 atgcaacatg atcagtcaga ttgtgctgcg gcagttgttt caacagttct tttatcttac
      481 aaaaaggaac tatcaatcat gaagattcgg gaaattattg gtacagacat gtatggaacg
      541 actgtcagtg gtattgtttc aggtctgaat aagttgaatt ttacagtaaa agctgttcga
      601 gtggcactgg aagatttgac tccaaaatta acatttcctg cgattcttca agttaagaat
      661 gatttaggtc aaaatcattt tgtggtatta catagtataa aggagaaaat aaatggaact
      721 cgtattacca aataattatg ttgctcttga gcaagaggag atgatgtatc ttgatggggg
      781 ggggcttatt taagcaagag tgcttgtcaa ggaatttgcg cagctttagc tatgagccca
      841 ggaactttta tagcattgac tggagctgca gttttaacaa aaaaactaat aaactatatt
      901 aaggttggag gccttggagg ttggcttatt ggtgcagcag caggtgtatt ggctcttatc
      961 tttttgataa aaatttgtgt agatactacg ataaaggttc tattaaacag aatctttaag
     1021 gcaagtaagg taatgaaaag gaggatattt tctctttttg tactagattt gatggtctat
     1081 atatttttag gttatgtttt agtgatacaa aaagacgtat atctgttttc aattctgata
     1141 attttttcta atttttcagt tccctttatc agagaaaaag agtatgaatt atttaaaaat
     1201 aagaaatgag atagatatgg tagctttatt aaaactgaga ataaagtttg ggagatattt
     1261 ttatttattt taggtgtgtt gttaattgta atttcattac taagtccccc aaaaattaaa
     1321 ttttggaaat agagttagtg agaaggatag gataatagta ttatgttgat tgttttaatt
     1381 tcagttattg ttgcattact gtatcataaa attacagagt atgtcaacaa caggaaaatt
     1441 gatattgtta tttttctatc attgctgatt tctcatttta tttggaatta ctatttttta
     1501 ccaattgaaa tattgatagc aatcagtgga gcaaatttac tattaagttt tttaaaaaaa
     1561 ttacagacta aataatatta atctgtgtaa tacagtagct cggtcattag attctattga
     1621 agatataaat taaaaatgag gctgggaaaa aactcaattt gaaaatgaga ttgagtaaat
     1681 ctttctatct atataacgta tatcatcaat atttttgaac acctgataat atgcattttt
     1741 cttattttaa agattttttg cctttcttca tttcttgaat gaattggaga gatgacttta
     1801 tttaggtgtt tgacattact atagatagga tttagcagta ctaatatgaa ctcatattat
     1861 aggtgtagac ttaaattttg gaagcaagct aaaggatatc ttatctaggt aactaagtgc
     1921 tataacaaga tatattggtg gagttagtat ggcaactatt actaatgctc ttaatattgc
     1981 ggctactgtt gctgaagtct tctcattagg aggagccatt gcatatggtt tagatatcgt
     2041 agacggtaaa tttgatgggt atttatgggc gtaaaactat agctatgaaa catttttttg
     2101 caggaattgg tgaaattcat tttttgttat ttttattata tctaagcatg tctgctagtc
     2161 caattattgg actagtgatt ggatatacta aaataaatct aataaattct attattatag
     2221 ctcttggtat gatattggca ttaattttgg tattatcaag agtgtataga aaatattttt
     2281 atagagacga tgatgactaa agtttttatc aataatttgg gctccttgtc aactgtagtg
     2341 ggttgaataa aagctaacgt ctggggaagg gtttaaagct ttgctttatc aaatattgac
     2401 ttacagagtt gctctattgt attgatgcat tcttagtaaa taatatggtg ttttgaatga
     2461 aagatgatca gaaatattta ttagcgggac tttattcgct tctagttgca atattttatt
     2521 ttccattgat tgattccaag gggatttttg taagtatatt gatggcggtt ttacttttat
     2581 atttaatata cttcattgca acagtcattc atattgtgat aattaagttt ataagaaaaa
     2641 aatcttttaa gtatttggtt ctatatccat ttacttatga tgggagctgg agatttcaac
     2701 ctataaactt actctacttt ccagaaatgg tgagagatgt cattccgatt aatttagttc
     2761 aagaatattg ccaaggacaa ccttacggac tgttaaaaaa gatgctgaaa agaattcgat
     2821 tgtcacgaga gatatcttta ctcctggcta ccattatcgt ctattttttt acgcatagaa
     2881 ttctaccttt ttcagtattt acgttcatgt tttcttatat attgctattt gtacaatctt
     2941 atttgggtgg taataccgct tggattggaa atagaagatt aataatagat gatgaatttg
     3001 aaaaaatctt gctttcaaaa agttatataa aagaaatatc atctgcacga tactcagaat
     3061 acttgacatg tgaatacaaa aactttacac caatcatatt gttagctatt tttgaaaatt
     3121 tgcttgactc ctacttgctt cagaatcaga gtgaggttga cttagatatt ttttataaag
     3181 ttttaccttt gctttataaa gaaaaatata ctatgggatt caattacttt gtaagtttaa
     3241 attatttact atataaggtt ggatttttgg gaatcattta cgataatgaa gcattaagag
     3301 atttgtcaaa acaatattta aacaaaaata tttcggaatt acaagatggt tctttcgagg
     3361 gcggtataca agatgctgtt gcctctaaac aaatagtagt tataaatgaa tttatagctt
     3421 gtttaaattc cagatgcatg ccatcccaat atgatagatt tttttataaa gatagacctt
     3481 atattttttc cagaaagagt cctattaagg ggtgaaaatt tgttacattt ggattaacaa
     3541 gtgtcctagg gattagaaat aactctagta tagctagata tttttgagta actagaaata
     3601 tcattagtct acccatatga ttgccagaaa agatggctga tgaatcttat ttatactgtt
     3661 gcagtaggcg ttgtctagga taaataagct atcttgatgg gggagattgg aataatttta
     3721 gtagaaacat taaaggatta tggacaagta gcgtaggatt aggtgatgca atgtgctaag
     3781 ttggcttggt gttaacagta gtattattta acaatggaaa gtagactaaa tgaaaaataa
     3841 gcgttatttt tttgacacaa ttttaataat tttactgctt ataagcacga tattttgtgt
     3901 cagcccagta tttataaaat tggacatctt aggaactccc tctcatgcca tcttaacctt
     3961 tgtattggcg ataccgttat tctatatttt gtctcaatgc ttacatactt tgctattact
     4021 agtttcctca atcttttgta aattaagacc aatttatttt tattttatat ttgtgatcat
     4081 tataggagct aggaaatact atcgaattct ctttcaccaa ctaatgggat ttagtccagg
     4141 aatagcagtg ttttataagg agagtcaaac aactaagaat ctgtttaaat tttactactt
     4201 cttgtacttt acaacactaa tttcatacta ttttttcttt acttttgtgt atgacaaacc
     4261 gttgcttttg cctcttattt cattttctat tatcatagca ttagtacaaa aactttatag
     4321 aattgagaat caacaattat ttctgttaaa atcaaaggta ctaacaatac tggaatctaa
     4381 gaagaattgt gagtttaatc ttcaggatta tcatgaaatt tggaaattgc aatcaaaatc
     4441 tgagttgcca tgcgtggctt tatcttatat cagtttaatc aagccatatc tttcagagag
     4501 tgtgcgtgaa caaattgatt tattagaagt taagcgattt aaaaaaataa ataatccaat
     4561 atcactttat ggtatgttgg atgttataaa attaaatcta tatttacggc attataatga
     4621 aaaaaataaa tatgaatcaa tgttaaagaa aattttagag gtaagaccag actttgtttt
     4681 aatcgagcag aatattgatg atagtttaaa tagctcgcaa ccattatctt tatctttagc
     4741 catttcagaa atccaacttt tgcttgaagt gtatataggg atcaaacatg tttcaattag
     4801 gagataaaac tagaataata tttgccatta taggggcaag ttgcatatta gtcagtatgt
     4861 atcttattcc acttattaaa actgagaata aattttggga aatactttta tttatattag
     4921 gtgtattgct aattggaatt gcgttactaa gtcaaaaaaa ataaattttg aaatagtatt
     4981 agtgagttcg caatcattta ttgctagtgg tttagaactg ttaagtttca aacaataatt
     5041 gattttaaac cttaggtaac ctataaaaac aaataaggta gagaaaggat atcttatcta
     5101 ggtagctaag tgataaaaac acagtcgtct atcacttgtt aggaaacgat cctaactatg
     5161 cttaataaaa aaggagaaaa taaatggaac tcgtattacc aaataattat gttgctcttg
     5221 agcaagaaga gatgatgtat cttgatgggg gattttctat tctgagatgg cctgttgcaa
     5281 cagccattaa tatagctttt aatggtgttt taggtggagg agcaatcagt ctagttagaa
     5341 attatattcg taattatggt ttgcggcgag ttacaagcgc aattgctgga gcagctgcaa
     5401 gatatgttgg ggtacgagtt gcaaatagag tggcaggatt tgcactgtct gctattaatg
     5461 gatttgcagc ttggatgtca attggcgatg ctattacaac aatctgggcc aacaatgatg
     5521 taaataggag agacccaaat ttaaacgcct tgtggtaact agatatgggt attaaaatgg
     5581 aaaaaatttt tgttattatt ttttttgtat gtctatttat atcatccata acttttttag
     5641 cctatgattt tgttagcgaa gaaataaaaa agttgattat ttggatgaat gtcgtttttt
     5701 tgattttaat catagcaatg ataatttatc caaaattaag aaaatgataa ggacactgta
     5761 aaattatgat acgtaaacta atcatttttt tattaatgct ccctcttttt gtcttgtggc
     5821 tagagttgca tttgttagtg agtaacttgc aattgaatct agaaattccc cttgattttg
     5881 tggttagtac gagtcttgct ttctgtagtt tgattttatc aaaaatagtt ttagacatac
     5941 tatacgcatt gaaagatttg tacaagaaag aagctcttat tacgattttt ccttttattt
     6001 ttataggcag gaagaaagta aatgtgaggt tctcgcccta tttttcattc catcgtaaaa
     6061 gtttgtcgcc tgatgattta agatctagga ttatatggag ttttattctt gaaattgcta
     6121 ttattctagt atttatttta aaaattcctt ttgcaatcat catgcttact acaatatttt
     6181 tctggactat aatggatatc aatcatctcg tttttaataa gacggaattt ctttttaatc
     6241 aaaataaatg ggaaaaagaa gattcgtttg aaagcgattt gacgaaaacg ttaaaggata
     6301 agatacaaaa atcagagcta agttattctg acttaatgtc tcttcagctg tatgatgcga
     6361 tgaaccaatc caccttttta acggatagtg aactttttga ggatattttg aaaaaaatcg
     6421 aagattctca taacaccctt ctgtgtacag gtcttgtcga gttactgctg tatgaaatgt
     6481 ctattagtaa caataacaac tggtccaaca aggttgataa aattaggata cacctcatca
     6541 gaatcaatca attagatttt ttctattata caagttggtt aaggcaaaat tttgatttct
     6601 gtatgaatag agagtatcat aaaatgaaat ctcggaaatt attactgagt aataaaaaga
     6661 tagtttaagt tcgtcctatt tgtaaaacaa atgaaacaat ttcaactaag gaggagaaaa
     6721 caaatggaac ttgtattacc aaataattat gttgtgattg atgaagaaga aatgatgtat
     6781 cttgatgggg gagcttattt aagcaagcgt gcttgtcaag gaatttgcgt agctttagct
     6841 atgagttcag gaacttttat agcattagct ggagctgcag ttttaaccaa aaaactaata
     6901 aactatatta aggttggagg tcttggaggc tggcttattg gtgcagcagc aggaaaaata
     6961 gcttactgta ttggatatgg tgctcttaat agaggttgtg atattagcgg gaacccttat
     7021 ccttgggatg gatttatatc tgcgacagta agatgaataa tgtagataag attcgaaaaa
     7081 tacatattat cgtatgttgg gtgtatatat ttttatcatt cagggcgatt ataaatgaca
     7141 cggagtattt tttgcttatt tttttagctt ttatctactc aatagtatca ctacctctat
     7201 attctgtgaa aaataaaata gtatctatct gtctagccat aaattcgatt ctgttaatga
     7261 gtttccccat tttaatcaat aagtttttcc cagaaagttt tttgacttat accgtattaa
     7321 taagtgtttt tatcctagag ttagcaatct ttcatttaat tggggaagat tttgctacta
     7381 aattgactaa cgaatataag aaaattagtc agtttagaag caaggtgtct caatcttctt
     7441 ggataaaata tttagagatt tctagtttta tattaactat atttccatct attctttacg
     7501 gtacagttga taatcgtgta ttggctctta tctttttgat aaaaatttgt gtagatacta
     7561 cgataaaatt tttattcatc agattatttg acacaagtac tttaatgaag aggagaatat
     7621 tttttctttt cgcattggat gttatagctt acttattttt aggatatctt ttagtgattc
     7681 aaaaagcagg ctatttgttt tcggttttac ttcttttttc taatttttca gttccattta
     7741 tcaaagcaaa ggaatacgaa ttatttaaaa atagcaagta atagaaacat aggttaaatc
     7801 ttagaacggc ttaaaatcag atatgataaa gggaaatagt cttatctagg taactaagtg
     7861 ctacaaacac agtcgaggat cacttgttag gattacattt taatcatgct taataagaat
     7921 ggagaattcc tatggggatt gtattactct gaagtttcga ataccttagt tctcgtgatt
     7981 ttgagctgtt ctagctttag aatccttcag aatgtaaaat tttaagcagt caaagactta
     8041 gaatagcctg gaaacattta ttttatagca attctaggct tagaattgct catatatatg
     8101 tatttgagct gctcgatagt taggacagct ctattctgag aaatctgagc tatcaatgct
     8161 tcagaatagt atttcgcaaa tggtttttat tgaagaggtg attgtgttat gatagtctaa
     8221 aataaaactg atttaatgga gtaaatggag aatcgtcaca tgaaacattt ttttgcagga
     8281 attggtgaga taaaacttgt tggctactta ttgtatatat gtgtaggact agcccttctt
     8341 tttcatatat atgtcatagg ttcggaactg agttttgtga aaatagtgtt atctattttg
     8401 ggagttatat ttgtaagtat gttaactatt gctcgaattt atcggacttt tctataaaga
     8461 atagtttgga cttgaactgt atctaaaaac agaggttggt cgattatcag cctctttctt
     8521 gtcgttgaaa agagtgagat atattgactt ttgaaaaaaa tgtcataatt gagttgggat
     8581 aaacctaaaa gtaatatagt agattgaatc tggaatagtc cgttatgact gttaaaatat
     8641 ttctagaaat taatttgact ttcctaatcg atttgttcac atcttgtttc aatctactat
     8701 actttctcgt taaaccgttc ggcaattcat ggtgacatgg acacatagta gtaagcacac
     8761 tatgtggctt ggcagagcta aaaactgttc ccttgcgata agcctaataa gcacaacata
     8821 gggagttaga gaagccgact ctaatcaacc actttgggca gtagtgagaa ctgccccgtg
     8881 cttttttatt ttgagaaaat atggagtttg tcgttgaaat tacttgattg tattttggac
     8941 tatcaagaaa gattcaatgg aaaaacatgt caagtatcaa cgaattataa gtatttagag
     9001 attttcaaag tgaatttttg cttgactgat ttacatcatt tatttgactt atacaaaatc
     9061 acacgagatt atgctagtca aacaaaacct gctattcaag ctggtgtttt tattttagaa
     9121 gattttagaa atatcctatg tacaatgatg taatcgaaag gatatcttta tatgagttta
     9181 tcggtgatat tttctattct aaaataataa gttgttgcat cgtagctagg gatttatcta
     9241 aaaatactat gaaattggac gtcatatttt ttgaggataa aaataaaaga tccgcagttt
     9301 taggtttacg aagagacaaa agcggagtat ttaaatcagt tactctacat tttacaagcg
     9361 ctaagaaata tgctaaagtt cgtaaaacag atgtgaaaga aatgaaatgg ctataaagat
     9421 tgtccgcagg cttaagcttg cgttttttgt tgtttaacga aattaaaaaa caagctctct
     9481 catcggaaat gtttttatag gaatgaagga agatgatgct atgtttaaaa agagaatcga
     9541 aaagggcaaa agtagtatct ttatctattt tttggagtag aagcttatga tatagaaatt
     9601 tgtaataaaa atgtaatata aaacatttga caaatattta cggggggagt atacttaata
     9661 taagtatagt ctaaaaatga ctatcagaaa agaggtaaat ttagatgaat aagaaaaaaa
     9721 tgattttaac aagtctagcc agcgtcgcta tcttaggggc tggttttgtt gcgtctcagc
     9781 ctactgttgt aagagcagaa gaagctcccg tagctaagca gtctcaagct gagagagact
     9841 atgatgcagc aatgaaaaaa tctgaagctg ctaagaaaga atacgaagaa gctaagaaag
     9901 atttagaaga agcaaaagct gctcagaaaa aatatgaaga cgatcaaaag aaaactgaag
     9961 agaaagcaaa gcttgttcaa aaagcggatg aagagcgtca aaaagcgaat gtggcagttc
    10021 aaaaggcgta tttaaaactc cgagaagcac aagaacaatt gaacaaaagt ccaaacaata
    10081 agaaaaatgc cgctcaacag aaattaaaag atgcattagc tcatattgat gaggtaacat
    10141 taaaacaaaa agaggcggaa gcgaatttca ataaggaaca agcaaaagta gttcctgaag
    10201 cagataagtt agctgagact aagaaaaaag cagaacaggc tgaaaaaaaa gaaccagaac
    10261 ttgctaaaaa agtagcagaa gctaaagcaa aagcagaaga agctgagaaa aaagctgttg
    10321 aagccaaaca aaaagtggat gctgaaaaat atgctcttga agctaaaatc gctgagttgg
    10381 aatatgaagt tcagggacta gaaaaagagc tcaaagagat tgatgagtct gactcagaag
    10441 attatattaa agaaggtctc cgtgctcctc ttcaatctaa attggatgcc aaaaaagcta
    10501 aactatcaaa acttgaagag ttgagtgata agattgatga gttagacgct gaaattgcaa
    10561 aacttgaaaa agatgtagaa gatttcaaaa actcagacgg tgagcaagct gaacaatatc
    10621 ttgttgcagc taaaaaagac ttagatgcta aaaaagctga attagaaaat actgaagctg
    10681 accttaagaa agcagttgat gagccagaaa ctccagctcc ggctcctaaa ccagccccag
    10741 ctccagctcc aactccaact ccagaagccc cagctccagc tcctaaacca gctccggctc
    10801 ctaaaccagc tccggctcct aaaccagctc cagctcctaa accagaaact ccaaaaacag
    10861 gctggaaaca agaaaatggt atgtggtact tctacaatac ggatggttca atggcaacag
    10921 gctggctaca aaataatggc tcatggtact acctcaacgc taatggtgct atggcaacag
    10981 gttgggctaa agtcaacggc ttatggtatt acctcaacag caatggcgct atggcgacag
    11041 gatggctcca atacaatgat tcatggtact acctcaatac taatggtgct atggcgacag
    11101 gttggctaga atacaatggt tcatggtact acctcaacgc taatggtgct atggcgacag
    11161 gttggctaga atacaatggt tcatggtact acctcaacag caatggcgct atggcgacag
    11221 gttggctcca atacaatggt tcatggtact atctaaacgc taacggcgct atggcaacag
    11281 gttgggctaa agtcaacggt tcatggtact acctcaacgc taacggttca atggcaacag
    11341 gttgggtgaa agatggagat acctggtact atcttgaagc atcaggtgct atgaaagcaa
    11401 accaatggtt caaagtatca gataaatggt actatgtcaa tggcttaggt gcccttgcag
    11461 tcaacacaac tgtagacgga tatactgtca atgaaaacgg tgaatgggtt taagccgatt
    11521 aaattaaatc atgttaagaa catttgacat tttaattttg aaacaaagat aaggttcgat
    11581 tgaatagatt tatgttcgta ttctttaggt acctatctta tgatttcagg aaatgtcatt
    11641 aaaaaaacga ctccttttct ctaacttgaa aaatagatta gagaaaatgg gttgttttat
    11701 ttattatagt tatttgaatg aagataagaa gaaggtatac tcacatcatt cacataatct
    11761 gtatattgac tataagtttt aaaaaacaat ttttaagctc ttccttgtct tctctaacca
    11821 agcgtgttat aatgaatact gctcaagcga ccttcaatcg tgaagcacac acgaccttca
    11881 atcgtgaata aacgaataga tgggagactt accatgagtg ataactctaa aacacgtgtt
    11941 gtcgtgggga tgagtggtgg tgttgattcg tcggtgacgg ctcttttgct caaggagcag
    12001 ggctacgatg tgatcggtat cttcatgaag aactgggatg acacagatga aaacggcgtc
    12061 tgtacggcga ccgaagatta caaggatgtg gttgcggtgg cagaccagat tggcattccc
    12121 tactactctg tcaattttga aaaagagtac tgggaccgcg tttttgagta tttcctagcg
    12181 gaataccgtg cagggcgcac gccaaatccg gacgttatgt gcaacaagga aatcaagttc
    12241 aaggcctttt tggactatgc cataaccttg ggggcagact atgtagcgac tgggcattat
    12301 gctcgagtgg cgcgtgatga ggatggcact gttcacatgc ttcgtggcgt ggacaatggc
    12361 aaggaccaga cctatttcct cagccaactt tcgcaagaac aacttcaaaa aaccatgttc
    12421 ccactaggac atttgaaaaa gcctgaagtt cgaaaactag cagaagaagc aggtctttcg
    12481 actgctaaga agaaagactc gacagggatt tgctttatcg gagaaaagaa ctttaaaaac
    12541 tttctcagca actacctgcc agctcagcct ggtcgtatga tgactgtgga tggtcgtgat
    12601 atgggcgagc atgctggtct tatgtactat acaatcggtc agcgtggcgg actcggtatc
    12661 ggtgggcaac acggtggtga caatgcccct tggttcgttg tcggaaaaga tctaagcaag
    12721 aatattctct atgtaggcca aggtttctac catgattcgc tcatgtcaac cagcctagag
    12781 gctagccaag tccactttac tcgtgaaatg ccagaagagt ttacgctaga atgtacggct
    12841 aaattccgtt accgtcagcc tgactctaag gtgaccgtcc atgtcaaagg agacaaggca
    12901 gaagttatct ttgcggaacc acaacgcgcg attacaccag gacaggcagt tgtcttttac
    12961 gatggcgaag agtgtctagg tggcggtttg attgacaatg cttaccgcga tggacaagtt
    13021 tgtcagtaca tttagattga caaattttct caatttgcta caataataac agcaatagaa
    13081 atgatggtca aagctcatgg atgttgcagg ct
//
LOCUS       DBMVGT010000047        12498 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.047, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000047 DBMVGT010000000
VERSION     DBMVGT010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 12498)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12498)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12498
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.047"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            192..752
                     /locus_tag="AC0DU4_001493"
     CDS             192..752
                     /locus_tag="AC0DU4_001493"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HIN4237440.1"
                     /translation="MLKKWQLKDVILLAFLSIFFGGVFVGSGYVYNILSLLLTPLGLQ
                     AFANEILFGLWCMAAPIAAIFVPRVGSATIGEVLAALAEVLYGSQFGLGALLSGLVQG
                     LGSEFGFIVTKNRYESWLSLTANSIGITLVSFVYEYIKLGYYAFSLPFVLSLLVVRFI
                     SVYFFCTILVRAIVKLYHQFATGGKA"
     gene            753..2138
                     /locus_tag="AC0DU4_001494"
     CDS             753..2138
                     /locus_tag="AC0DU4_001494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4237441.1"
                     /translation="MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQVI
                     AQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILLQNPNHQFTMENLFEELIFTLENI
                     GYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPF
                     ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDHMVELRDGKLREVFQIPS
                     YEMTQVASKEVAASPELFHMNRVTGELGNRSLFSIADFTFYQGISCILGDNGVGKSTL
                     FRSILQFQKYKGRITWKGSVLKKKKSLYRDLTGVVQEAEKQFIRVSLREELQLDGPDS
                     ERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDD
                     RACHYFCKWIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLT
                     SQSSNTQGEVR"
     gene            2140..2790
                     /locus_tag="AC0DU4_001495"
     CDS             2140..2790
                     /locus_tag="AC0DU4_001495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     component T"
                     /protein_id="HIN4237442.1"
                     /translation="MVKVATQTPIISLFLLILSLETSFLPSIALNLLVVAFCILFMLY
                     YRRFKMLAWMIILAILPSFANYWAVQLHGDASQAVMLGTRAFVTVCIGLVFVSSISLK
                     ELLLYLAQKGLSRSWSYALIVVFNSFPLIQQEIKSLKEACLLRGQELHFWSPLIYSKV
                     LMTVFRWRHLYLRALSAHGYDEHAQLKNSYRTFYIPKKTKLIYLLFFLLLQTSLFL"
     gene            2801..3559
                     /gene="tenA"
                     /locus_tag="AC0DU4_001496"
     CDS             2801..3559
                     /gene="tenA"
                     /locus_tag="AC0DU4_001496"
                     /EC_number="3.5.99.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000397218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050334 - thiaminase activity [Evidence
                     IEA];
                     GO_process: GO:0006772 - thiamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiaminase II"
                     /protein_id="HIN4237443.1"
                     /translation="MEFTDIAMELSKKAWQASFHHPFILQLQEGNLEPAIFRYYLIQD
                     AYYLKAFSEIYHLLADKTSNQEMKRLLKQNAQGLVEGELFIRQQFFKEMEISDQEMEQ
                     HPIAPTCYHYISHIYRQFAEPNLAIAFASLLPCPWLYHDIGKSLNLKPSPNPLYQQWI
                     ETYITDELEQQIREEGALVNQLYRESDETDKQKMLDAFHISVHMEAKFWEMAYQHQTW
                     KSDLQSLEKGEEWKHEKAPTTSSQINHFIYDDCP"
     gene            3498..4022
                     /gene="thiW"
                     /locus_tag="AC0DU4_001497"
     CDS             3498..4022
                     /gene="thiW"
                     /locus_tag="AC0DU4_001497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001225563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005215 - transporter activity [Evidence
                     IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy coupling factor transporter S component
                     ThiW"
                     /protein_id="HIN4237444.1"
                     /translation="MRKHQLQVHKLTILSMMIALDVVLTPIFRIEGMAPMSSVVNILA
                     GIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALLAGLFYKYGRKFYFSALGE
                     IVGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFIAFRFLIKQEF
                     FKKVQGYFFSERID"
     gene            4022..4825
                     /locus_tag="AC0DU4_001498"
     CDS             4022..4825
                     /locus_tag="AC0DU4_001498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HIN4237445.1"
                     /translation="MQEFTNPFPIGSSSLIHCITNEISCEMLANGILALGCKPVMADD
                     PREVLDFTKQSQALFINLGHLSAEKEKAIRIAASYAAQVCLPMVVDAVGVTTSSIRKS
                     LVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYPG
                     MSFLVTGPKDLIVSENQVAVLGNGCAELDWITGTGDLVGALTAVFLSQGKTGFEASCL
                     AVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE"
     gene            4818..5450
                     /gene="thiE"
                     /locus_tag="AC0DU4_001499"
     CDS             4818..5450
                     /gene="thiE"
                     /locus_tag="AC0DU4_001499"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HIN4237446.1"
                     /translation="MNREALRLYLVTNRYQDSVESFLAKIETACRSGVTIVQLREKNL
                     TTNQYYQLAKQVKEITDAYQVPLIIDDRLDVCLAVDAAGLHIGDDELPVSVARQVLGP
                     EKILGVTAKTVKRALEAEKSGADYLGTGAIFPTTTKENAPITLISTLKTICQTVAIPI
                     VAIGGLTSENIDQLMGTGIAGVAVVRDLMQAEDIEAKTQAFLTKLHDILS"
     gene            complement(5659..6450)
                     /gene="thiD"
                     /locus_tag="AC0DU4_001500"
     CDS             complement(5659..6450)
                     /gene="thiD"
                     /locus_tag="AC0DU4_001500"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA];
                     GO_process: GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HIN4237447.1"
                     /translation="MTYLPVALTIAGTDPSGGAGIMADLKSFQARDVYGMAVVTSLVA
                     QNTRGVQLIEHVSPQMLKAQLESVFSDIPPQAVKTGMLATTEIMEIIQPYLKKLDCPY
                     VLDPVMVATSGDALIDSNARDYLKTNLLPLATIITPNLPEAEEIVGFSIHDPEDMQRA
                     GRLILKEFGPQSVVIKGGHLKGGAKDFLFTKNEQFVWESPRIQTCHTHGTGCTFAAVI
                     TAELAKGKSLYQAVDKAKAFITKAIQDAPQLGHGSGPVNHTTFKD"
     regulatory      complement(6534..6632)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            6816..7211
                     /locus_tag="AC0DU4_001501"
     CDS             6816..7211
                     /locus_tag="AC0DU4_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0006825 - copper ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CopY/TcrY family copper transport repressor"
                     /protein_id="HIN4237448.1"
                     /translation="MQISDAEWQVMKIIWMQGEQTSTDLIRVLAERFDWSKSTVQTLL
                     ARLVDKECLTRKKEGKSFVYSALLTLDQSRDLLVQDIKDKVCSRRIRNLLADLIVECE
                     FTQTDLEDLEAVISEKKSSAVTEVRCNCM"
     gene            7222..7593
                     /locus_tag="AC0DU4_001502"
     CDS             7222..7593
                     /locus_tag="AC0DU4_001502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005507 - copper ion binding [Evidence
                     IEA];
                     GO_function: GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cupredoxin domain-containing protein"
                     /protein_id="HIN4237449.1"
                     /translation="MLNSIVTIICIALIAFILFWFFKKPEKSGQKAQQKNGYQEIRVE
                     VMGGYTPELIVLKRSVPARIVFDRKDPSPCLDQIVFPDFGVHANLPMGEEYVVEITPE
                     QAGEFGFACGMNMMHGKMIVE"
     gene            7603..9846
                     /locus_tag="AC0DU4_001503"
     CDS             7603..9846
                     /locus_tag="AC0DU4_001503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042625 - ATPase-coupled ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HIN4237450.1"
                     /translation="MTEIVKASLENGIQKIRIRAEKGYHPAHIQLQKEIPAEITFHRA
                     TPSNCYKEILFEEEGILEPIGVDEEKVIRFTPQELGRHEFSCGMKMQKGSYIVVEKTR
                     KSLSLLQRFWITSIFTVPLVILMIGMLTGSISHQVMHWGTFLATTPIMLVAGKPYIQS
                     AWASFKKHNANMDTLVALGTLVAYFYSLVALFAGLPVYFESAGFILFFVLLGAVFEEK
                     MRKNTSQAVEKLLDLQAKTAEVLSDDSYVQVPLEQVKVGDLIRVRPGEKIAVDGVVVE
                     GVSSIDESMVTGESLPVDKTVGDTVIGSTINHSGTLVFRAEKVGSETVLAQIVDFVKK
                     AQTSRAPIQDLTDKISGIFVPVVVILGIMTFWVWFVLLRDSVVVLGASFVSSLLYGVA
                     VLIIACPCALGLATPTALMVGTGRSAKMGVLLKNGTVLQEIQKVQTLVFDKTGTLTEG
                     KPVVTDVIGDEVEVFGLAASLEDASQHPLAEAIVKRASEAGLEFQTVENFQSLHGKGV
                     SGRINGKQVLLGNAKMLDGMDISNTYQDKLEELEKEAKTVVFLAVDNEIKGLLALQDI
                     PKENAKLAISQLKKRGLRTVMLTGDNAGVARAIADQIGIEEVIAGVLPEEKAHEIHKL
                     QQSGKVAFVGDGINDAPALSVADVGIAMGAGTDIAIESADLVLTTNNILGVVRAFDMS
                     KKTFHRILLNLFWAFIYNVVGIPIAAGVFSGVGLALNPELAGLAMAFSSVSVLTSSLL
                     LNFSKID"
     gene            10053..11828
                     /gene="spxB"
                     /locus_tag="AC0DU4_001504"
     CDS             10053..11828
                     /gene="spxB"
                     /locus_tag="AC0DU4_001504"
                     /EC_number="1.2.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047112 - pyruvate oxidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate oxidase"
                     /protein_id="HIN4237451.1"
                     /translation="MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKD
                     IRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAIL
                     GSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAVSKKGPAVV
                     EIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGV
                     KAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLF
                     LGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPV
                     ESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTT
                     QTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPD
                     VITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFT
                     VDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKE
                     KYEAEELVPFRLFLEEEGLQSRAIK"
     gene            11939..12286
                     /locus_tag="AC0DU4_001505"
     CDS             11939..12286
                     /locus_tag="AC0DU4_001505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003017645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HIN4237452.1"
                     /translation="MNLNQLDIIVSNVPQVCADLEHILDKKADYADDGFAQFTIGSHC
                     LMLSQNHLVPLENFQSGIIIHIEVEDVDQNYKRLNELGIKVLHGPTVTDWGTESLLVQ
                     GPAGLVLDFYRMK"
BASE COUNT         3558 a         2405 c         2778 g         3757 t
ORIGIN      
        1 tcttttacga aactggatga agatgatata gtagattgaa ataagatgcg aacaaatcaa
       61 ttagaaaatt caaattaatt tctagaaata ttttagcatt cttgtgtact gttctaaatt
      121 cagtctgcta tacaaagtat ttaggtcggt cttcttgagt gccccacttt tctttaaaaa
      181 aaggagtttt tatgttgaaa aaatggcagt taaaagatgt tatcttgctt gctttcttgt
      241 ctatcttttt tggtggggtt ttcgttggtt caggatatgt gtataatatt ctcagtctac
      301 tcttaacacc tcttggtttg caggcctttg ccaatgaaat cctcttcggt ctctggtgta
      361 tggctgcgcc cattgctgcc atctttgttc caagagtcgg aagtgcaacg attggagaag
      421 tgctagctgc gcttgctgaa gtcctttatg gtagccaatt tggtctagga gctcttttgt
      481 ctggcttggt tcaaggtttg ggaagtgaat ttggttttat cgtaactaag aatcgctatg
      541 aaagttggct ctctctaact gctaatagta ttgggattac gcttgttagc tttgtctatg
      601 aatacattaa gttaggttac tacgcctttt cccttccgtt tgtcctttcc ttacttgtgg
      661 tacgttttat ttctgtttat ttcttctgta ccatcttggt tcgtgccatt gtcaaactct
      721 atcatcagtt tgcaactgga ggaaaagcat agatgggtct ggaactacga gcgattcagt
      781 ccccaatctt ctctgagccg tttgatttta cttttcatgc gcaagccttt accttgttag
      841 ttgggagcag tggttcagga aaatccagcc tttttcaagt cattgcccaa gtcagttctc
      901 ttccctatag tggtcaagtc ctgatagatg ggagcgaggt cagtcagctt tctatcatcg
      961 cacgtgtcca gaaggttggc attctcttgc aaaatcccaa tcatcaattt accatggaga
     1021 acttgtttga ggagttgatt ttcaccttgg agaatatcgg ctatcacctt caggaaattg
     1081 attctaaaat agcagaggtt gtccagcaat gtcgttgcga ggcaatctta caccgtccca
     1141 ttcatcacct atcaggtggg gaaaagcaaa aagcagcgct ggctgtcctc tttgccatga
     1201 atcctagggt ctatctcttg gatgagccct tcgcttccat tgaccgcaag agtagaatcg
     1261 agatattgga gattctaaaa gagttggctc ttgatgggaa gacagtcatt ttgtgcgacc
     1321 atgatttatc tgactataaa gcctatatcg accatatggt tgagctaaga gacggaaaac
     1381 taagggaagt gtttcaaatc ccttcctatg agatgacaca ggttgcttca aaggaagttg
     1441 ctgctagccc ggaattattc catatgaacc gtgtgactgg tgagcttgga aatcgctccc
     1501 tcttttcgat tgctgatttc acattctatc aagggatttc ctgtatcctg ggtgacaatg
     1561 gtgtcgggaa atcaaccctc tttcgctcta ttcttcaatt tcaaaagtat aaggggcgca
     1621 ttacttggaa gggttcggtc ctgaaaaaga aaaagagttt gtatcgtgat ctgactggtg
     1681 ttgttcagga agctgagaag cagtttatcc gagtcagtct gcgagaggag cttcaattag
     1741 atggacctga ttctgaaaga aatcagcgga tttttcaagc tttacgatat tttgatttgg
     1801 agcaggcagt cgataagagt ccctatcaat taagtggtgg tcagcaaaaa attcttcagc
     1861 tcttgaccat cttgaccagt aaggcttccg tgatcttgct agatgaacct tttgcaggtt
     1921 tggatgatag agcctgccat tatttttgca agtggattgt ggaggagagg aatcaaggaa
     1981 gaagttttct gctcattagt catcgtttag accctttgat ttctgtggtt gattattgga
     2041 ttgagatgac tagtcagggt cttcggcatg tgaaagaagt gaccattacc aaaccactta
     2101 catctcagag tagcaatacc caaggggagg tgagatagta tggtcaaagt agcaacccag
     2161 acaccgatta tcagtctctt cttgctgatt ttatccttgg aaacatcttt ccttccttcg
     2221 attgctctga atcttttggt agtcgcattt tgtattctct ttatgctcta ttaccgtcga
     2281 tttaaaatgt tagcttggat gatcatactt gccattttac catcttttgc caactactgg
     2341 gcagttcagt tacacggaga tgcttcacag gcagtcatgc ttggaacgag ggcctttgtg
     2401 acagtttgta tcggccttgt ctttgtttcc tctatttcac taaaagagct tctcttgtac
     2461 ttggctcaaa aggggctatc acgctcttgg tcctatgcct tgattgtggt attcaattct
     2521 tttcctctca ttcagcaaga aatcaagtcc ctcaaagaag cttgcctatt acgtggtcaa
     2581 gaactacatt tttggtcgcc cttgatttac agtaaggttc tgatgacagt ctttaggtgg
     2641 cgccatcttt acctgagagc tctatctgct cacggatatg acgaacatgc acagttgaag
     2701 aatagctatc ggacttttta tattcctaaa aaaacaaaat taatctacct gcttttcttt
     2761 ttattgcttc aaaccagtct atttttataa aggagttatt atggaattta cagatattgc
     2821 gatggaatta tccaagaaag cttggcaggc ttcctttcat catcccttta ttttacaatt
     2881 acaagagggg aatttagaac ctgccatttt ccgctattac ctgattcagg atgcctacta
     2941 tctgaaggcc ttctcagaaa tctatcatct tttggctgat aagacttcaa accaagagat
     3001 gaaaagactc ttgaaacaaa atgctcaggg tttagtggag ggtgagttat ttattcgcca
     3061 acaatttttc aaggaaatgg aaatcagcga ccaggaaatg gagcaacatc caatcgctcc
     3121 aacctgttat cattacattt ctcatattta taggcaattt gcagaaccga acttagccat
     3181 cgcttttgca agcttgcttc cttgtccttg gttataccat gatataggca aatcacttaa
     3241 tcttaaacca tcaccaaatc ctctctatca acaatggatt gaaacttata ttacggatga
     3301 gttagagcaa cagatcagag aggagggagc actggtcaat cagctctatc gagaaagtga
     3361 cgagacagac aagcaaaaaa tgctagatgc cttccacatc agtgttcata tggaagccaa
     3421 gttttgggaa atggcctacc aacaccagac atggaagagc gatttacagt ctttagaaaa
     3481 aggagaagaa tggaagcatg agaaagcacc aactacaagt tcacaaatta accattttat
     3541 ctatgatgat tgcccttgat gtagtcctta cacctatctt tcggattgag ggaatggcac
     3601 cgatgtccag tgtagtcaat attctagcgg gaatcatgat gggacctgtt tatgccttgg
     3661 ctatggctac agtgacagcc tttatccgta tgacgactca agggattccg cctttagctc
     3721 tcacaggagc gacttttgga gcccttctag caggtctctt ttataagtac ggtcgaaaat
     3781 tttacttttc tgccttggga gaaattgtgg gaacaggtat tattggttct attgtttcct
     3841 atcctgttat ggtactcttt acaggatcag ctgctaagct tagctggttt atctacacgc
     3901 ctcgattttt cggagcaacc ttgattggta cagcgatttc ctttattgcc tttcgatttt
     3961 taatcaagca ggaattcttt aaaaaagtgc agggatattt ctttagtgaa aggatagact
     4021 gatgcaggaa tttacaaatc cctttcctat aggctctagt tccctcattc actgcattac
     4081 caatgagatt tcttgtgaga tgctggcaaa tgggattttg gctctgggat gcaaacctgt
     4141 catggcagat gatccccgtg aggttcttga ttttactaag caaagtcagg ctctcttcat
     4201 caatttgggg catttgtcag ctgagaagga gaaagcaatc cgtatagcag cttcttatgc
     4261 agctcaagtt tgtctcccaa tggtagtaga tgcggttggc gtaacgactt catccattcg
     4321 taagagctta gttaaagacc ttttagacta tagacctacg gtccttaaag gaaacatgtc
     4381 agaaattcga agtcttgttg gattaaagca ccacggcgtt ggggtcgatg cgagtgctaa
     4441 agatcaagaa acggaggatt tgcttcaagt cttgaaagac tggtgtcaga cctatcctgg
     4501 tatgtcattc ttagttactg gccccaagga cctcatcgtt tcggagaatc aagttgctgt
     4561 actgggaaat ggctgtgcag aattagactg gataacaggg acaggagatt tggttggagc
     4621 cttaacagcc gtttttctca gccaaggaaa gactggtttt gaagcttctt gcttagcagt
     4681 ctcttatctt aatatcgctg ctgagaaaat agttgttcaa ggaatgggat tggaagaatt
     4741 tcgttaccaa gtactcaatc agctttcgct cctaagaaga gatgaaaatt ggctagatac
     4801 catcaaagga gaggtttatg aatagagaag cacttagact atatctggta accaatcgct
     4861 atcaagattc cgtggaaagc tttcttgcaa aaattgagac ggcctgccgt tcaggggtta
     4921 ccatagtcca attgcgagaa aaaaatctca caaccaatca atattatcaa ctggcaaaac
     4981 aagtcaagga aataacagat gcttatcagg tacccttgat aatcgatgat cggttggatg
     5041 tttgtcttgc ggttgatgct gctggtctgc atattggaga tgacgaactc ccagtttcgg
     5101 ttgcccgaca agtcttgggt cctgaaaaaa tcctcggtgt caccgctaaa acggttaaaa
     5161 gagctctgga agcggagaaa tcaggtgcag attacttggg gacaggagcc atttttccga
     5221 caaccaccaa ggaaaatgca cccatcaccc tgatttcaac cttgaaaaca atttgccaaa
     5281 cggttgccat tccaatagtt gctattggcg gcttgacttc ggagaatatt gatcagctta
     5341 tgggcactgg catagctggt gtagctgttg tacgtgattt gatgcaagca gaagatattg
     5401 aggcaaaaac gcaagccttt ttaacaaagt tgcatgacat tctttcctaa ttaatactca
     5461 atgaaaatca aagagtaaac tagaaagcta gtcgcaggtt gctcaaagta ctgccttgag
     5521 gttttagata agactgacga agtcagctca aaacagtgtt ttgaagttgc agatggaagc
     5581 tgacgtagtt tgaagagatt ttcgaagagt ataaaaactc tctaattccc ttaaagtggg
     5641 aactagagag tttttttctt aatctttaaa agttgtatgg ttgactggac cagaaccatg
     5701 accgagttga ggggcatctt gaatagcttt tgtgataaag gccttggcct tatcaactgc
     5761 ctggtaaaga ctcttgccct tggctagttc agcagtaatc actgcagcaa aggtacatcc
     5821 agtaccatgg gtgtgacagg tttgaattcg tgggctttcc cagacaaatt gttcattctt
     5881 ggtaaagagg aaatctttag caccaccttt gagatgtccg cctttgataa ccacagactg
     5941 aggaccaaat tcttttaaaa tcaggcgacc agcacgctgc atgtcttcgg ggtcatggat
     6001 tgaaaaacca acaatctctt ctgcttcagg aagatttggc gtaataatag ttgctagagg
     6061 tagtaagttt gttttgagat agtctctagc atttgagtca atcaaggcat ctccacttgt
     6121 agcaaccata acaggatcaa ggacataggg acaatccagt tttttaagat agggttggat
     6181 gatttccatg atttcagtag tagccaacat tccagttttt acagcctgag gtggaatatc
     6241 agaaaagaca ctctccaatt gggctttcaa catttgagga gaaacgtgct cgattagctg
     6301 aacacctctg gtattttgag cgacaagact ggttacaaca gccattccat agacatctct
     6361 cgcttggaat gactttaaat ctgccataat gccagcacca ccactagggt cagtccctgc
     6421 aatggtcaaa gcaacgggta aataagtcat ctaaaacctc ccaaccaact gaagtttgta
     6481 ttcttaagaa caagctagtc tgttttagaa aggcaataga agactgctag tccccattat
     6541 catttccact tccatcagct agcattacct agattgagtc agagggatct agcagtcgtt
     6601 aatctcagct ttacgcaccc ctagtggttg ttttcttttt tctttagtat agcatatttt
     6661 tattgtttat atagtaatat ttgactgcaa atcgtttttc aaatgattaa aattctattt
     6721 ttcgaagaaa atattatttc tataattgac aaatgtagat tttaagagta tactgataag
     6781 tgtaattgac aaatgtagat tttggaggta tggtaatgca gatttcagat gcagaatggc
     6841 aggtcatgaa gattatttgg atgcaggggg agcagaccag tacagatttg attagggttt
     6901 tggcagagcg gtttgactgg tccaagtcca cggttcagac acttttggct cgtctggttg
     6961 ataaagagtg tttgactcgg aaaaaagaag gcaagtcctt tgtttattca gcccttttaa
     7021 ctctagacca aagtcgggat ttacttgtcc aagatatcaa agacaaggtt tgttcccgta
     7081 ggattaggaa tttgttggct gacttgattg tagaatgtga atttactcag actgacttgg
     7141 aagacttgga agctgtgatt tcagagaaga aatcaagtgc tgtaacagaa gtaagatgta
     7201 attgtatgta aaggagacgt catgttaaat agtattgtaa ccattatttg tattgctctt
     7261 atcgcgttta tcttgttttg gtttttcaaa aagcctgaaa aatctggaca aaaagcccag
     7321 caaaaaaacg gataccaaga gattcgagtg gaagtcatgg gaggctatac tcctgagttg
     7381 attgtcctca agagatcagt gccagcccgc attgtctttg accgcaagga tccttcacca
     7441 tgtctggatc aaattgtttt tccagatttt ggtgtacatg cgaacctgcc aatgggggaa
     7501 gagtatgtag tggaaatcac gcctgagcag gctggagagt ttggctttgc ttgtggtatg
     7561 aacatgatgc acggcaagat gattgtagag taggtggaga ctatgacaga aattgtgaaa
     7621 gcaagcttag aaaatggcat tcaaaaaatc cgtatccgag ctgaaaaagg ctatcatcca
     7681 gcccatatcc agcttcaaaa ggaaattcca gctgagatta cctttcatcg tgctactcct
     7741 tcaaactgtt ataaggaaat tctgtttgaa gaagaaggta tcttggaacc aatcggcgta
     7801 gatgaggaga aagtcattcg ttttacacct caagaattag ggcgacatga attttcttgt
     7861 ggcatgaaga tgcaaaaggg aagctatata gtcgttgaga agactcgaaa atctctatct
     7921 ctcctgcaac gtttttggat tactagtatc tttactgtgc ctcttgtgat tctcatgatt
     7981 gggatgttga caggtagcat tagtcatcaa gtcatgcatt ggggaacctt tctagcaaca
     8041 acgcctatta tgttagttgc aggtaagcca tatatccaga gtgcttgggc cagttttaaa
     8101 aagcacaatg ccaacatgga taccttggtt gcgctgggaa ctctagtggc ttatttctat
     8161 agcctagttg ctctctttgc tggtctccct gtttacttcg aaagtgctgg atttatcctc
     8221 tttttcgttc ttttgggagc agtttttgag gaaaaaatga gaaaaaatac gtcccaagct
     8281 gtggagaaat tactggactt gcaagctaaa accgcagaag tcttgagtga tgatagttat
     8341 gtccaagttc ctttggaaca agtcaaggta ggcgacctga ttcgagtgcg tcccggtgaa
     8401 aagattgctg ttgatggtgt cgtagtagaa ggtgtctcta gtattgacga atccatggtg
     8461 acaggtgaga gtctgcctgt ggacaagaca gttggagata ctgtcattgg ctcaaccatc
     8521 aatcatagtg gaacgcttgt ctttagagca gaaaaagttg gctcagagac tgttttggct
     8581 cagattgtgg attttgtgaa gaaagctcag acaagtcgtg cgccgattca ggacttgacg
     8641 gataagattt cagggatttt tgtcccagta gttgtcattt taggaatcat gaccttttgg
     8701 gtttggttcg tcttgctcag ggatagtgtg gttgtgcttg gagctagctt tgtgtcctct
     8761 cttctctacg gagtggcggt tttgattatc gcctgtcctt gtgccttggg acttgcaaca
     8821 ccgacagccc ttatggtggg gacaggacgt agtgccaaga tgggggttct cctcaaaaat
     8881 ggaactgtct tacaggaaat ccagaaagtt caaacccttg tctttgataa gaccgggact
     8941 ttgacggaag ggaaacctgt ggtaacagat gtcatcggcg acgaagtaga agtgtttggg
     9001 ttggcagcct ccttggaaga tgcttctcaa cacccactgg ctgaggctat cgttaagcga
     9061 gcgagtgaag ctggacttga gtttcaaact gttgaaaatt ttcagtcctt gcacgggaaa
     9121 ggtgtttcag ggcgaatcaa tggaaaacaa gttttacttg gaaatgctaa aatgctggat
     9181 ggcatggata tttctaatac ttatcaagat aaactagaag aactagaaaa agaagctaag
     9241 acagttgtgt tcttagctgt tgacaatgaa atcaaaggct tgcttgcttt gcaagatatt
     9301 cctaaggaaa atgctaagct agccatcagt cagctaaaaa aacgtggtct ccgaacagtc
     9361 atgctgacag gagacaatgc tggtgtggcg cgtgctattg cagatcaaat cggaattgaa
     9421 gaggtcattg caggcgtctt gccagaagaa aaagcccatg aaatccataa actgcaacag
     9481 tcagggaaag tagcctttgt tggggacggt atcaatgacg ctcctgccct tagtgtagca
     9541 gatgtgggaa ttgctatggg tgctggaaca gatatcgcca tcgagtcagc agatttggtg
     9601 ttgacaacca ataatatttt aggagtggtt cgtgcctttg atatgagtaa gaaaaccttt
     9661 catcgaattc tactcaatct tttctgggct tttatctaca atgttgtcgg aattccgatt
     9721 gcagcaggag tcttttcagg tgttggactg gctctcaacc cagaattggc aggtctagcc
     9781 atggccttta gttctgtatc tgttctgacc agttcccttc tgttaaattt tagtaaaata
     9841 gactaaaagt aatgactaga tttctttgtt ataaaacaga aatgacaaca ctttcaaaac
     9901 tgtattagaa tagagaatag agagttttga gcagattttt agaaaagtca gcataaatat
     9961 gatacagtgg aatagtaaaa atttggagaa cgtttccaat tctatgtaat cgtattctcc
    10021 aagtctaaaa aaattgaagg agagttatca ttatgactca agggaaaatt actgcatctg
    10081 cagcaatgct taacgtattg aaaacatggg gcgtagatac aatctacggt atcccatcag
    10141 gaacactcag ctcattgatg gatgctttgg ctgaagacaa agatatccgt ttcttacaag
    10201 ttcgccacga agagacaggt gctcttgcag cggttatgca agctaaattc ggcggctcaa
    10261 tcggggttgc agttggttca ggtggtccag gtgcgactca cttgattaac ggtgtttacg
    10321 atgcagctat ggataacact ccattcctag cgatccttgg atcacgtcca gttaacgaat
    10381 tgaacatgga tgctttccaa gagcttaatc aaaacccaat gtacaacggt atcgctgttt
    10441 acaacaaacg tgtagcttac gctgagcaat tgccaaaagt aattgacgaa gcctgccgtg
    10501 ctgcagtttc taaaaaaggt ccagctgttg ttgaaattcc agtaaacttc ggtttccaag
    10561 aaatcgatga aaactcatac tacggttcag gttcatacga acgctcgttc atcgctcctg
    10621 ctttgaacga agttgaaatc gacaaagctg ttgaaatctt gaacaatgct gaacgcccag
    10681 ttatctatgc tggatttggt ggtgttaaag ctggtgaagt gattactgaa ttgtcacgta
    10741 aaatcaaagc accaatcatc acaactggta aaaactttga agctttcgaa tggaactatg
    10801 aaggtttgac aggttctgct taccgtgttg gttggaaacc agccaacgaa gtggtctttg
    10861 aagcagacac agttcttttc cttggttcaa acttcccatt cgctgaagtt tacgaagcat
    10921 tcaagaacac tgaaaaattt atccaagtcg atatcgaccc ttacaaactt ggtaaacgtc
    10981 atgctcttga cgcttcaatc cttggtgatg ctggtcaagc agctaaagct atccttgaca
    11041 aagtaaaccc agttgaatca actccatggt ggcgtgcaaa cgttaagaac aaccaaaact
    11101 ggcgtgatta catgaacaaa ctcgaaggta aaactgaggg tgaattgcaa ttgtatcaag
    11161 tttacaatgc aatcaacaaa catgctgatc aagacgctat ctactcaatc gacgtaggta
    11221 acactactca aacatctact cgtcaccttc acatgacacc taagaacatg tggcgtacat
    11281 ctccactctt tgcgacaatg ggtattgccc ttcctggtgg tatcgctgct aagaaagaca
    11341 atccagatcg ccaagtatgg aacatcatgg gtgacggagc attcaacatg tgctacccag
    11401 acgttatcac aaacgttcaa tacgaccttc cagttatcaa ccttgtcttc tcaaatgctg
    11461 agtacggctt catcaagaac aaatacgaag atacaaacaa acacttgttt ggtgtagact
    11521 tcacaaacgc tgactacgct aaaattgcgg aagctcaagg agctgttgga ttcacagttg
    11581 accgtatcga agacatcgat gcagttgttg cagaagctgt taaattgaac aaagaaggta
    11641 aaactgttgt catcgatgct cgcatcactc aacaccgtcc acttccagta gaagtacttg
    11701 aattggatcc aaaacttcac tcagaagaag ctatcaaagc cttcaaggaa aaatacgaag
    11761 cagaagaact cgtaccattc cgtctcttct tggaagaaga aggattgcaa tcacgcgcaa
    11821 ttaaataatt cctctcgtcg aaaatcaaat atgaaacttg tagactttat tctttgattt
    11881 tcatagagca gaactttaaa agatcggagc aatccggtct ttttatggag gagagtaaat
    11941 gaatttaaat caattagata ttatcgtttc aaatgttccc caagtctgtg ctgacttgga
    12001 gcatatcttg gataaaaagg cagattatgc tgatgatggt tttgctcagt ttacgattgg
    12061 tagtcactgc cttatgttgt cacaaaatca tttggttcct ttggaaaact ttcagtcagg
    12121 aatcattatt catatcgagg ttgaggatgt agaccagaac tacaaacggt tgaacgagct
    12181 tggtataaag gttttacacg gaccaactgt aaccgattgg ggaacagagt ccttattagt
    12241 tcaaggacct gctggtctag tgcttgattt ttatcgtatg aaataggtcg cgtagtcatt
    12301 tgacgttaac cttagctatt tttaaaatag aaattgagaa tatgaactat tgaaagatcg
    12361 gagcaatccg gtctttttat ataaagaaat tgcatataat actcatctgc tttcaaaaag
    12421 cattctagtc catctccgat taacgatgga ctttatcacc tccttctcca atccttgtat
    12481 gacatcttgg agttgatt
//
LOCUS       DBMVGT010000048        12398 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.048, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000048 DBMVGT010000000
VERSION     DBMVGT010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 12398)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12398)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12398
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.048"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1260
                     /locus_tag="AC0DU4_001506"
     CDS             <1..1260
                     /locus_tag="AC0DU4_001506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HIN4237453.1"
                     /translation="DNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLIDVGPGAGV
                     FGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVIGARENNLQN
                     VTARFPLGKFIAVTGVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHVDR
                     LIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRCEA
                     CSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVEFF
                     QHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYILDE
                     PTTGLHTEDIARLLKVLARFVDDGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGTII
                     VTGTPEEVAANEASYTGHYLKGKLHHE"
     gene            1253..2314
                     /locus_tag="AC0DU4_001507"
     CDS             1253..2314
                     /locus_tag="AC0DU4_001507"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004177 - aminopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_function: GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="M24 family metallopeptidase"
                     /protein_id="HIN4237454.1"
                     /translation="MNKRVQAFLAKMQEKELDGIIINNLKNVYYLTGFWGSNGTVFIS
                     RDRQVLVTDSRYIIAAKQETSGFEIVADRDELAVIAGIVKDMGLTRIGFEDEISVSYY
                     HRMQAAFAGLDLLPQTQFVEGLRMIKDEAEIAAIRKACSISDQAFRDALDFIKPGKTE
                     IEIANFLDFRMRELGASSLSFDTILASGINSSKPHAHPMHKPVELGEAITMDFGCLYD
                     HYVSDMTRTIYLGHVSDEQAEIYNTVLKANQALIDQAKAGLGFRDFDKIPRDIIIEAG
                     YGDYFTHGIGHGIGLDIHEEPYFSQTSTETIKTGMALTDEPGIYIEGKYGVRIEDDIL
                     ITETGCELLTLAPKELIVI"
     gene            2446..2844
                     /gene="spx"
                     /locus_tag="AC0DU4_001508"
     CDS             2446..2844
                     /gene="spx"
                     /locus_tag="AC0DU4_001508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768833.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator Spx"
                     /protein_id="HIN4237455.1"
                     /translation="MIKIYTVSSCTSCKKAKTWLNAHQLSYKEQNLGKEGITREELLD
                     ILTKTDNGIASIVSSKNRYAKALGVDIEDLSVNEVLNLIMETPRILKSPILVDEKRLQ
                     VGYKEDDIRAFLPRSVRNVENAEARLRAAL"
     gene            2910..3479
                     /locus_tag="AC0DU4_001509"
     CDS             2910..3479
                     /locus_tag="AC0DU4_001509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP0191 family lipoprotein"
                     /protein_id="HIN4237456.1"
                     /translation="MKKIVLVSLAFLFVLVGCGQKKETGTATKTEKDTLQSALPVIEN
                     AEKNTVVTKTLVLPKSDDGSQQTQTITYKDKTFLSLTIQQKRPVSDELKTYIDQHGVE
                     ETQKALLEAEEKDKSIIEARKLAGFKLETKLLSATELQTTTSFDFQVLDVKKASQLEH
                     LKNIGLENLLKNEPSKYISDRLANGATEQ"
     gene            3566..3832
                     /locus_tag="AC0DU4_001510"
     CDS             3566..3832
                     /locus_tag="AC0DU4_001510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HIN4237457.1"
                     /translation="MGFTEETVRFKLDDSNKKEISETLTDVYASLNDKGYNPINQIVG
                     YVLSGDPAYVPRYNNARNQIRKYERDEIVEELVRYYLKGQGVDL"
     gene            3836..4255
                     /gene="ruvX"
                     /locus_tag="AC0DU4_001511"
     CDS             3836..4255
                     /gene="ruvX"
                     /locus_tag="AC0DU4_001511"
                     /EC_number="3.1.21.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003090938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HIN4237458.1"
                     /translation="MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIQINEEQGQFGFDR
                     VKELVDTYKVERFVVGLPKNMNNTSGPRVEASQAYGAKLEEFFGLPVDYQDERLTTVA
                     AERMLIEQADISRNKRKKVIDKLAAQLILQNYLDRKF"
     gene            4271..4576
                     /locus_tag="AC0DU4_001512"
     CDS             4271..4576
                     /locus_tag="AC0DU4_001512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HIN4237459.1"
                     /translation="MSHDHNHDHEERELITLVDEQGNETLFEILLTIDGKEEFGKNYV
                     LLVPVNAEEDEDGQVEIQAYSFIENEDGTEGELQPIPEDSEDEWNMIEEVFNSFMEE"
     gene            4835..6085
                     /locus_tag="AC0DU4_001513"
     CDS             4835..6085
                     /locus_tag="AC0DU4_001513"
                     /EC_number="6.3.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000464354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008841 - dihydrofolate synthase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="folylpolyglutamate synthase/dihydrofolate
                     synthase family protein"
                     /protein_id="HIN4237460.1"
                     /translation="MFEVEEWLHSRIGLNFRSGLGRMQQAVDLLGNPEQSYPIIHVTG
                     TNGKGSTIAFMRELFMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLTDQVKE
                     MEKTLLQTPAQLSFFELLTLVAFLYFREQEVDLVLLEVGIGGLLDTTNVVTGELAVIT
                     SIGLDHQETLGDSLEAIAEQKAGIFKDGKKAVIAKLPPEARLVCQKKAESLAVNLYQA
                     GQDFLMLNGDFSSSLLNLSQLNIGLEGVYQQENAALALQTFLLFMREGKEAVDEQAVR
                     KALEQTHWAGRLERIRPQIYLDGAHNLPALTRLVEFIKEKEQEGYRPQILFGSLKRKD
                     YQGMLGYLTENLPQVELKMTGFDYQGSLDETDVTGYHVIPSYREFISSFEERADAQDL
                     LFVTGSLYFISEVRGYLLDREQIN"
     gene            6169..6624
                     /locus_tag="AC0DU4_001514"
     CDS             6169..6624
                     /locus_tag="AC0DU4_001514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0198 family lipoprotein"
                     /protein_id="HIN4237461.1"
                     /translation="MKLKRFTLSLASLASFSLLVACSQRAQQVQQPVAQQVQQPAQQN
                     TNTANAGGNQNQAAPVQNQPVAQPTDIDGTYTGQDDGDRITLVVTGTTGTWTELESDG
                     DQKVKQVTFDSANQRMIIGDDVKIYTVNGNQIVVDDMDRDPSDQIVLTK"
     gene            6770..8302
                     /gene="cls"
                     /locus_tag="AC0DU4_001515"
     CDS             6770..8302
                     /gene="cls"
                     /locus_tag="AC0DU4_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000877342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008808 - cardiolipin synthase activity
                     [Evidence IEA];
                     GO_function: GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA];
                     GO_process: GO:0032049 - cardiolipin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HIN4237462.1"
                     /translation="MKYRKFQLLMSKYGFSLSIMLLELCLVFGLFLYLGRMAPILWIT
                     VLILLSIITIISIVNRNTTPENKVTWLLVAFVPVFGPLLYLMFGERRLSKKEIKQLKK
                     LGSMHFQEANSQLLKEKLKESDKAAYGVIKSLLSMDTNADIYDQTASTFFPNGEAMWK
                     KMVEDLKKAEKFIFLEYYIIEEGLMWNRILDILEQKVAQGVEVKMLYDDIGCMATLTG
                     DYAHRLRQLGIEAHKFNKVIPRLTVAYNNRDHRKILIVDGQIAYTGGVNLADEYINHV
                     ERFGYWKDSGIRLDGLAVKALTRLFLTTWYINRGEISDFDQYHLENHSIPSDGLTIPY
                     GSGPKPIFRAQVGKKVYQSLINQATESVYITTPYLIIDYDLTETIKNAAMRGVDVRII
                     TPYIPDKKFIQLVTRGAYPDLLSAGVRIYEYSPGFIHSKQMLVDEDFAVVGTINLDYR
                     SLVHHYENAVLLYKTPSIMEIARDFRNIFADSQEVYPHSIKTSWYQKLVKEIAQLFAP
                     IL"
     gene            8380..8523
                     /locus_tag="AC0DU4_001516"
     CDS             8380..8523
                     /locus_tag="AC0DU4_001516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000956126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237463.1"
                     /translation="MLTKEEVNDMIEFKQTHLHRFREIETFVKLCKKSLKQPSQADNP
                     RTF"
     gene            8560..10098
                     /locus_tag="AC0DU4_001517"
     CDS             8560..10098
                     /locus_tag="AC0DU4_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="damage-inducible protein CinA"
                     /protein_id="HIN4237464.1"
                     /translation="MSVYGRVEEVHKENREPLEYQIEQESHHRESSRLPLVKILLWST
                     LVTGITLGVPLLLDLMSAQEVQDFYAGWALHQTGKIYSDYYGSQGLLYYLLTYVSQGG
                     YFFAIFEWLALVAGGFFLFRSADTLTEQGDQAGHLVTIFYMLVTGLAFGGGYATLLAL
                     PFLFAAFSLVAAYLSNPSHDKGFVRIGLALAGGFFFAPLSSLLFIAVVSLGLLVFNLG
                     HRRFVHGFYQFLAVALGFSLVFYPTAYYSAATGSFGDAISGIRYPIDSIRFDFTSKIL
                     ENMFFYGLLSLGLGFVVCIFLGLFQSKPFKLYVISVPASLVVILGLILLFFSQEPLHA
                     SYLMVVFPVFLLLLVTNIKSQQRGRSARRSRRETPVSLWSRFFKGNLYLLVFGFVYLL
                     SVPFLMKFVLYPVPYQERNRLADLVKEETNTEDAIYAWDDTATLYRKSERLSPSAILY
                     PLHYTATEENRNKLLNDLKEKQPKVIVVNDKVVVWSEVETLLKENYQQVKTDYSEFKV
                     YKIK"
     gene            10218..>12398
                     /gene="nrdD"
                     /locus_tag="AC0DU4_001518"
     CDS             10218..>12398
                     /gene="nrdD"
                     /locus_tag="AC0DU4_001518"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004239081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008998 - ribonucleoside-triphosphate
                     reductase (thioredoxin) activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase"
                     /protein_id="HIN4237465.1"
                     /translation="MIALEEKITILPTLFVEKRDGRRVVFDVDKIDKALHKAADKVMD
                     VTPLVEKRLNDLTERIITEIHSRFPQGIKIYEIQNIVEHELLEAKEYALAEEYITYRT
                     QRDFERSKATDINFSIHKLLNKDQTVVNENANKDSDVFNTQRDLTAGIVGKSIGLQML
                     PKHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLENGFKIGNAEVESPKSIQTA
                     TAQISQIIANVASSQYGGCSADRIDEILAPYAEKNYQKHLKDAEEWVLPEKREDYAWK
                     KTQKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGTSRFEREIQKAILNIRIKGLG
                     SEHRTAIFPKLIFTLKRGLNLEEGTPNYDIKQLALECATKRMYPDVLSYDKIVDLTGS
                     FKVPMGCRSFLQGWKDENGVEVNSGRMNLGVVTVNLPRIALESEGDMNKFWEIFNERM
                     NIAEDALVYRVERTKEATPANAPILYQYGAFGHRLGKEESVDQLFKNRRATVSLGYIG
                     LYEVATVFFGNSWESNPDAKEFTLDIIHDMKRRVEEWSDQYGYHFSIYSTPSESLTDR
                     FCRLDIDKFGSIPDITDKEYYTNSFHYDVRKNPTPFEKLDFEKVYPEAGASGGFIHYC
                     EYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDRCYKCDFEGDFEPTERGFACPNCGN
                     SDPKTVDVVKRTCGYLGNPQARPMVNGRHKEIAARVKHMNGSTIK"
BASE COUNT         3775 a         2319 c         2793 g         3511 t
ORIGIN      
        1 gacaatgacc gcctgattgc cagtctgaaa aagatgcgtg acttgggcaa tactcttatc
       61 gtggtggaac acgacgaaga taccatgcgt gaagctgatt atctgattga cgttggtcct
      121 ggtgccggtg tttttggtgg tgagattgtt gcagcaggta cacctaagca agtggctcgc
      181 aacagcaagt ctatcacagg tcagtacttg tcaggcaaac gtgtcatccc agtaccagaa
      241 gagcgccgtg tcggaaatgg tcgttttatt gaagtgatag gagcgcgtga gaacaacttg
      301 caaaatgtca cggctcgctt tccactagga aaatttatcg cagtgacagg tgtgtcgggt
      361 tcagggaaat cgactctaat caacagcatt ctcaaaaaag ccattgccca gaagctcaac
      421 cgtaattcag acaaacctgg taagtttaag actattacag ggattgagca tgtcgaccgt
      481 ttgattgata ttgaccagag ccctatcgga cggacgccga ggtctaaccc agctacctat
      541 acaggagttt ttgacgatat acgtgacctt tttgctcaga caaatgaagc caagattcga
      601 ggctacaaga aggggcgctt cagtttcaac gtcaagggag gtcgctgtga agcttgctca
      661 ggtgacggga ttatcaagat tgagatgcac ttcttgccag atgtttatgt ggcttgtgaa
      721 gtttgccacg gaacccgcta taacagtgaa accctagaag ttcactacaa ggaaaagaat
      781 atttcgcagg tcttggatat gacggtcaac gatgcggtag aatttttcca acacattccg
      841 aaaattcaac gcaaactcca gaccatcaag gatgtagggc taggctatgt gaccttggga
      901 cagccagcta ccaccctttc tgggggagaa gcccaacgta tgaagttagc tagcgaactc
      961 cacaaacgct cgacaggaaa atctttctac attctggatg agccgacgac agggcttcat
     1021 acagaggaca ttgctcgcct gctcaaggtt ttagctcgct ttgtagacga tggcaataca
     1081 gtcctcgtca tcgagcacaa tctggatgtt atcaagacgg cagaccatat cattgacttg
     1141 ggacctgagg gcggtgtcgg tggtggaacc atcatcgtaa caggaactcc agaagaagta
     1201 gctgccaatg aagccagcta tacaggacac tatttgaaag gaaagttaca tcatgaataa
     1261 acgcgtacaa gcatttctag ctaaaatgca agaaaaagaa ctagatggta tcatcatcaa
     1321 caatcttaaa aacgtctatt atttgactgg tttttggggc tcaaacggaa cagtctttat
     1381 cagccgtgac cgtcaggtct tagtgacaga ctctcgctat atcatcgcag ctaagcaaga
     1441 aaccagtggt tttgagattg tggctgatcg tgatgaattg gctgtcattg caggaattgt
     1501 taaggacatg ggcttgactc gtatcggttt tgaagatgag atttcagtat cttattacca
     1561 ccgtatgcag gcagcttttg caggtttgga cttgcttcca caaactcaat ttgtggaagg
     1621 tcttcgtatg attaaggatg aggcagagat tgcagcgatt cgcaaggctt gttctatctc
     1681 agaccaagct ttccgcgatg cgcttgactt tatcaaacca ggaaaaactg aaattgaaat
     1741 tgccaacttc cttgatttcc gcatgcgtga gttgggagca tctagcttat cttttgatac
     1801 gatcctagct agcggtatca attcttctaa accccatgcc catccaatgc acaaaccagt
     1861 ggagttggga gaagccatta ccatggactt cggctgtctc tatgaccact atgtcagtga
     1921 tatgacccgg actatctatc tagggcatgt tagcgatgag caggcagaga tttacaatac
     1981 ggttctaaaa gctaaccaag ccttgattga ccaagctaag gcaggcttag gtttccgtga
     2041 ctttgacaaa atccctcgtg atattatcat tgaggcaggt tatggcgact actttactca
     2101 cggcattggc cacggtattg gtctggatat ccatgaggaa ccctacttta gccagacttc
     2161 tacagaaact attaagacag gtatggcctt gaccgatgaa ccaggtatct atatcgaagg
     2221 caaatatggc gttcgtatcg aggatgatat cctgattaca gagacaggtt gtgaattatt
     2281 gaccctagct ccaaaagagt tgatagtcat ttagttgttt gtcaagaaaa aagtacgaaa
     2341 atgacgaaaa aagtcaaaaa aaattaaaaa taggtcgcaa gtcggatgtt ttttatggta
     2401 taatagacta aactgatagt aacatgtagc gaaaggggta ggtacatgat taaaatttat
     2461 acagtctcaa gttgtactag ctgtaaaaaa gcaaaaacct ggctcaatgc ccaccagtta
     2521 agttataaag aacaaaacct tggtaaagaa ggaattacga gagaagaatt actggatatt
     2581 ctaaccaaaa cagataacgg aatagccagc atcgtttcgt ctaaaaatcg ctatgccaaa
     2641 gcccttggag tggatattga agatttgagt gtcaatgaag ttctcaatct gattatggaa
     2701 acaccgagaa ttttaaagag cccaatcctt gtagatgaaa aacgcctgca agttggctac
     2761 aaggaagacg atattcgtgc cttcctacca cgctctgtcc gtaatgtaga aaatgcagaa
     2821 gcacgtttac gtgcagctct ataaacatca aggctgggag cacttcccag tcttattcta
     2881 ttttaatttc aaaaagaaag aagagagaaa tgaaaaaaat agttcttgtt agtctagctt
     2941 tcctttttgt cctggttggt tgcggacaga aaaaagaaac tggaacagct acaaaaacag
     3001 aaaaggatac gcttcagtcg gcattgccag ttattgaaaa tgccgagaag aatacagttg
     3061 taaccaagac tttggtcttg cccaagtcag atgatggtag ccagcaaact caaaccatta
     3121 catacaagga caagactttt ttgagcttaa cgattcaaca aaaacgtcca gtttctgatg
     3181 agttgaagac ttatatcgac caacatggag tggaagaaac tcaaaaagct cttcttgaag
     3241 cggaggagaa ggataagtct atcattgaag ctcgtaaatt ggcaggtttc aaacttgaaa
     3301 caaaactatt gagcgcaacg gaacttcaaa caacgactag ttttgatttt caagttctgg
     3361 atgtcaagaa ggcttcccag ttggaacatc tgaagaatat tggtttggaa aatcttttga
     3421 aaaatgaacc aagcaaatat atttcagata gattggcaaa tggcgcgaca gaacaataga
     3481 aaatccaaat aaatagactg cctgaattgt agaaggtaag gaattatgct ataatggtac
     3541 tattctaagg aaagagggtg ttagaatggg atttactgaa gaaacagtac gttttaaatt
     3601 ggacgattcc aataaaaaag aaattagcga aactttgaca gatgtttatg cttcgttgaa
     3661 cgataagggt tacaacccaa ttaaccaaat cgtaggttac gtattgagtg gagaccctgc
     3721 ctacgttcct cgttataata atgcacgaaa tcaaatccgt aagtatgagc gtgatgaaat
     3781 cgttgaggaa ttggttcgtt actacctcaa aggacaagga gtcgatctat aacctatgag
     3841 aattatggga ttggacgtcg gttcaaaaac ggtaggggtg gcgattagcg atccgcttgg
     3901 ttttacagct caagggcttg aaatcatcca gataaatgaa gaacaaggcc aatttggttt
     3961 tgaccgcgtt aaggaattgg ttgatactta caaggtagaa cgatttgtag tgggcttgcc
     4021 taaaaacatg aacaatacaa gtggaccgcg cgtagaagct agtcaagcct acggagcaaa
     4081 gctagaagag ttttttggtt taccagtaga ctatcaggat gaacgcttga caacagtggc
     4141 tgctgagcgc atgttgattg aacaagcaga tatcagtcgc aataagcgca agaaagtcat
     4201 tgataagtta gcagctcagc tgattttaca aaattattta gatagaaaat tttaatataa
     4261 aggagaggct atgtcacacg atcataacca cgaccacgaa gaacgtgaac taatcacact
     4321 agtagatgag caaggaaatg aaaccttgtt tgaaatcctt ttgacaattg atggaaaaga
     4381 agaatttggt aaaaactatg ttcttctagt accagttaac gcagaagaag acgaagacgg
     4441 acaagttgaa atccaagctt actcattcat tgaaaatgaa gatggaacag aaggcgaatt
     4501 gcaaccaatc ccagaagact cagaagacga atggaacatg attgaagaag tcttcaacag
     4561 ctttatggag gagtgataca gtctgggaga ctgtatcagc ccaactccca gaaatgggga
     4621 agagttggaa cgtccagtga acatttttac cccaactctt agaacttgag aagagttgga
     4681 acatctagtg gatgttttta gcccatattc acattcatag tagctagtta ttagctaacc
     4741 aggtaagagg tcgggacgaa aatcctggcc ttgtttttat tagtaaccat actttaatgc
     4801 gataattgat tggacttttg tcaaggagat gtgtatgttt gaagtagaag aatggctcca
     4861 tagtcggatt ggtttgaatt ttcgatcagg tttgggccga atgcagcaag cggtggattt
     4921 gttaggaaat cctgagcagt cttaccctat tatccacgta acagggacta atgggaaagg
     4981 atctaccatt gcttttatga gggaattatt tatggggcat ggcaaaaaag ttgcgacctt
     5041 tacctcccct catatcgtct ctatcaatga ccgaatctgc attaatgggc aacctatagc
     5101 agacgcagac tttatccgtt tgactgatca ggtcaaagag atggagaaaa cgcttctgca
     5161 aactcctgcc cagttgtcct tttttgaatt gctgacctta gttgcttttc tttattttag
     5221 ggagcaggag gtggatttgg ttttattaga agtgggaatt ggtggcttac ttgacacgac
     5281 caatgtggta actggagagc ttgctgtcat cacctccatt gggcttgacc atcaagaaac
     5341 cttgggtgat agtctagaag caattgcaga gcagaaagct ggtattttca aggatggtaa
     5401 gaaggcagtg attgcgaaat tgcctccaga agctaggctt gtctgtcaga aaaaagccga
     5461 atctttagct gttaaccttt atcaggcagg tcaagatttt ttaatgctga atggtgattt
     5521 ttcaagctct ttactaaatc tttcacagct gaacataggc ttagaaggag tctatcagca
     5581 ggagaatgca gccttggcgt tgcaaacttt tcttcttttt atgagagaag gaaaggaagc
     5641 tgttgatgaa caggctgtaa gaaaggcctt ggaacagacc cattgggctg gtcgcttgga
     5701 gcgtattcgc ccacagattt acttggatgg tgctcataac ctccctgcct tgactcgctt
     5761 ggttgagttt atcaaagaaa aagagcagga aggctatcga cctcaaatcc tctttggatc
     5821 cttgaaacgg aaggattatc aagggatgtt gggttatctg actgaaaatt tacctcaagt
     5881 ggaactcaaa atgaccggct ttgactatca agggtctttg gacgagacag atgtcacagg
     5941 ttaccatgta attccctctt accgagaatt tatcagcagt ttcgaagaaa gggcagacgc
     6001 tcaagacttg ctgttcgtta cagggtctct ctattttatc tcagaagtac ggggctacct
     6061 gctggaccgt gagcagataa attgaccccc ttgtttgaac ttgttatact aggggaattg
     6121 ctggttagag aaaatttctc taaattggta gcagaaagga aattcatcat gaaattaaaa
     6181 agattcacac tttctcttgc ttctctagca agttttagtc tcttagtagc ttgttcacaa
     6241 agagctcaac aggttcaaca gcctgttgct cagcaggtcc aacagcctgc tcaacagaat
     6301 accaatactg caaatgcagg aggtaaccaa aatcaagcgg ctccagtaca aaaccaacct
     6361 gttgctcaac cgaccgatat tgatgggact tatactggtc aggatgacgg agaccgtatc
     6421 actttagtgg taactggaac gactggtaca tggactgagc tcgaatctga cggggatcag
     6481 aaagtcaaac aggttacatt tgattcagca aatcaacgca tgattattgg cgatgatgtc
     6541 aaaatttaca ctgtaaacgg taatcaaatc gtcgtagatg atatggatag agacccatcg
     6601 gaccaaatcg ttttaactaa ataagactat gcaagtagaa agggctggat ttttcagcct
     6661 ttttactttt acctagaaaa taatcataaa tacttgcctt ctaccgaata cctgcgttat
     6721 actagtatca attacttgtt tttagcattc aaactatcaa ggaggggata tgaaatatag
     6781 gaaatttcaa ttattgatgt ccaagtatgg ctttagtctt tcgattatgc tacttgaact
     6841 ttgtcttgtt tttggtctct ttctttattt aggacgcatg gctcccattt tatggattac
     6901 tgtcctcatt ctactgagta tcatcacaat catttcgata gtcaaccgta atacgactcc
     6961 tgagaataag gtaacctggt tgttagtagc ctttgtgcca gtatttggtc ccttgctcta
     7021 tctgatgttt ggtgaaaggc gattgtccaa aaaagaaatc aaacaactga agaagctagg
     7081 ctctatgcat ttccaagaag caaatagcca gctactaaaa gagaaattaa aagaaagtga
     7141 caaggcagct tatggagtca tcaagtcctt attgagtatg gataccaatg ctgacatcta
     7201 tgatcaaact gcctctacat tttttcctaa cggagaagct atgtggaaaa agatggtaga
     7261 agatcttaaa aaggctgaga aatttatttt cttggaatat tacattatag aagaaggttt
     7321 gatgtggaat cgcatactag atatactaga gcaaaaggta gctcagggtg tagaggttaa
     7381 gatgctctat gatgatatcg gctgtatggc tactttaaca ggagattatg cacatcgact
     7441 tcgtcagctg ggcatcgagg cccataaatt caataaagtt attcctcgtt tgacagtggc
     7501 ttataataac agagatcata gaaaaatatt gattgttgat ggtcagatag cctatactgg
     7561 tggggtcaat ctggcagatg agtacattaa ccacgtcgag agatttggtt attggaagga
     7621 tagtggaatt cgcttagacg gactagcagt aaaagccctg acacgcttat ttttgaccac
     7681 ttggtacatt aatcgaggag aaattagtga ttttgatcaa tatcatttag aaaatcattc
     7741 tatcccgagt gacggtttaa ccattccata cggaagtgga cccaagccaa tttttcgagc
     7801 gcaggtaggg aaaaaagttt atcagagttt aatcaatcaa gcaacggaat cggtctatat
     7861 tacgacacct tatttgatta tagattatga tttaacagag acaatcaaaa atgcagctat
     7921 gagaggggtc gatgttcgaa ttatcacccc ttacatacca gataagaagt tcattcagtt
     7981 agtcacgaga ggggcttatc ccgaccttct ttctgctggt gttcggattt atgagtatag
     8041 tccaggtttt attcatagta agcagatgtt ggtagacgaa gattttgcgg tggtggggac
     8101 aatcaatctc gactaccgga gcttggtaca ccattatgaa aatgcagtct tactctataa
     8161 aactccttct ataatggaaa tcgcccgaga ttttcgaaat atatttgcag attctcagga
     8221 agtctatcct cattctatca aaacgagctg gtatcaaaag cttgtaaaag aaatcgccca
     8281 gctattcgcc cctatcttat aagaaatcta gaacttagga tacaaaccag acctattttt
     8341 cttgtctttt acgaatagaa agaaagagga ggggaattca tgctaactaa ggaagaagtg
     8401 aatgatatga ttgagttcaa acagacacat ttacaccgct ttcgggaaat tgaaaccttt
     8461 gtgaaactat gcaaaaaatc actcaaacag ccatcgcaag ctgacaatcc taggactttt
     8521 tgatatacta agacagataa attgaacagg agaaacgata tgagtgtgta tggtagagta
     8581 gaagaagttc ataaggagaa tcgtgaacct ctagaatacc aaatcgaaca agaatcgcat
     8641 catcgtgaat caagtcgtct tcctttggtg aaaattttac tatggagtac gcttgtaacg
     8701 gggataactc taggagtacc gctattactc gacttaatga gtgcacaaga agtgcaggat
     8761 ttttatgcag gttgggcgct tcatcagaca gggaagattt acagcgacta ttatggaagt
     8821 caaggtttgc tttattattt gctgacttac gtgagtcagg gcggatattt ctttgccatc
     8881 tttgagtggt tagccttggt agcaggagga tttttccttt ttagatcagc ggacaccttg
     8941 acagagcaag gagaccaagc tggacatctg gtgactattt tttacatgct agttacaggt
     9001 cttgcttttg gtggaggcta tgcgactctt ttagcgcttc ctttcttatt cgcagccttt
     9061 agtttagttg cggcttacct aagcaatcca agccatgata agggatttgt acggattggg
     9121 ctagctttgg caggcggatt tttctttgct cccttatcat cgctcctgtt tattgctgta
     9181 gtgagtttag gcttgttggt ctttaacctt gggcatagac gttttgtgca tgggttttat
     9241 cagtttcttg cagtggcttt aggtttttca cttgtctttt atccaactgc ctactatagt
     9301 gctgcaacag gaagttttgg ggatgcgatt agtggtattc gttatcctat tgacagtatt
     9361 cgctttgatt ttacttctaa aattttagag aatatgtttt tttatggctt gttgtccctt
     9421 ggtttgggat ttgtggtttg tatcttttta ggtctctttc aatccaaacc ctttaaacta
     9481 tacgtcattt cggttcctgc aagtcttgtg gtaattttag gtttgatttt acttttcttt
     9541 tcacaagagc ctctgcacgc ttcttatttg atggtcgtct tccctgtttt cctactttta
     9601 ttggtaacca atattaagag tcaacagagg gggcgtagtg ctagaagaag ccgaagagaa
     9661 acgccagtta gcctatggag tcgtttcttc aaaggaaatc tatatctgct agtttttggg
     9721 tttgtctatc ttttgtctgt tccttttttg atgaagtttg tcctttatcc agtaccttat
     9781 caagaacgta atcgtcttgc tgatttggta aaagaggaga caaatacgga agatgctatc
     9841 tatgcatggg atgatactgc gactctttat cgtaagagtg agcgcttgtc gccatcggcg
     9901 attttgtacc cgttgcacta tacagcaact gaagaaaatc gtaataagtt acttaatgac
     9961 ttgaaagaaa aacaacctaa ggtgattgtg gtaaatgaca aggtggtagt ctggtctgaa
    10021 gtggaaacac tcttaaaaga aaattaccaa caagtaaaga ctgattactc agagtttaaa
    10081 gtctataaaa ttaaataacc aaatcaatat cttgtgtatt tttaaaaatt ttaggatttt
    10141 taacacaaga tattgatttt tctttttaga gtggtataat actttttaga aagaacattt
    10201 tagaaaagag catgcatatg attgcactag aagaaaaaat tacaattttg ccaactctct
    10261 tcgtcgagaa acgagatggg agacgtgttg tatttgatgt ggacaagatt gacaaggctc
    10321 tccacaaggc ggctgacaag gttatggatg tgacacccct ggttgaaaaa cgcctcaatg
    10381 atctgactga gcgaattatt acagaaattc atagtcgctt tccacaggga attaagattt
    10441 acgaaattca aaatatcgta gaacatgaac tccttgaagc caaagaatat gcactggctg
    10501 aggagtatat tacttatcgg acacagaggg attttgagcg ctcaaaagcg acggatatca
    10561 actttagtat tcataaactt ctcaacaaag accagacagt tgtcaatgaa aatgctaata
    10621 aagacagtga tgtctttaac actcagcgtg atttgacagc agggattgtt gggaaatcaa
    10681 tcggactgca aatgcttcct aagcacgtag ccaatgccca ccaaaagggg gatatccact
    10741 atcacgattt ggactacagt ccctataccc ctatgaccaa ctgctgtttg attgatttta
    10801 agggtatgtt ggaaaatggt tttaagattg gaaatgcaga ggtagagagt cccaagtcta
    10861 tccagactgc gacagcacag atttctcaaa tcattgccaa cgttgcttct agccagtacg
    10921 gtggctgttc agctgaccgt atcgatgaaa ttttggcgcc ttatgcagag aagaactatc
    10981 aaaaacatct caaagatgca gaagagtggg tattgcctga aaaacgggaa gattacgctt
    11041 ggaagaaaac gcaaaaggac atctacgatg ccatgcaatc tcttgagtat gaaatcaata
    11101 ctctcttcac ttcaaatgga caaacacctt ttacttcgct aggttttggt ctgggaacca
    11161 gtcgttttga acgagaaatt caaaaagcta ttttaaacat tcgcatcaag ggtcttggtt
    11221 cagaacaccg tacggctatc tttcctaaac ttattttcac tctgaaaaga ggccttaatt
    11281 tagaggaagg aactcccaac tacgacatca agcagttggc tcttgagtgt gcaaccaaac
    11341 ggatgtatcc agatgtttta tcttacgata agattgttga cttgacagga tccttcaagg
    11401 tgcctatggg ttgccgttct ttcctccaag gatggaagga tgaaaatggt gtagaagtca
    11461 attcaggtcg catgaatctg ggtgttgtga cggttaatct gcctcgtatt gctcttgagt
    11521 ctgaaggtga tatgaataag ttctgggaaa tcttcaacga gcgaatgaat atcgcagaag
    11581 atgctcttgt ttaccgtgtc gaacgcacta aagaggcgac accagcgaat gctcctatcc
    11641 tttatcagta cggtgctttt ggccatcgtc taggtaaaga agaaagtgtt gaccagctct
    11701 ttaagaatcg tcgtgcgacc gtttcgctgg gctatatcgg cttgtatgaa gtagcgacag
    11761 ttttctttgg taacagctgg gaaagtaatc cagatgctaa ggaattcacg ctagacatca
    11821 ttcacgatat gaaacgccgt gtagaagagt ggtcagacca atatggctac catttctcta
    11881 tctactcaac accatccgaa agtctgacag accgtttctg tcgactagat atagacaagt
    11941 ttggctctat tcctgatatc acagacaagg aatactacac caactctttc cactacgatg
    12001 ttcgtaaaaa tccaacaccg tttgaaaaat tggactttga gaaagtctat ccagaagcag
    12061 gtgcgtcagg tggtttcatc cattattgtg agtatccagt ccttcagcaa aatccaaagg
    12121 ccttggaagc tgtctgggat tatgcttatg accgtgtagg ctatctaggc accaatactc
    12181 cgattgaccg ttgctacaag tgtgactttg aaggggattt tgaaccaact gagagagggt
    12241 ttgcttgtcc aaactgtggc aatagcgacc ctaaaacagt agatgtggtg aagcgaactt
    12301 gtggctacct aggtaatcct caagcaagac cgatggtcaa cgggcgtcac aaggaaatcg
    12361 ctgcgcgtgt caaacatatg aatggttcaa cgattaaa
//
LOCUS       DBMVGT010000049        12273 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.049, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000049 DBMVGT010000000
VERSION     DBMVGT010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 12273)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12273)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12273
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.049"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1548
                     /gene="mutL"
                     /locus_tag="AC0DU4_001519"
     CDS             <1..1548
                     /gene="mutL"
                     /locus_tag="AC0DU4_001519"
                     /inference="COORDINATES: protein motif:HMM:NF000950.0"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0032300 - mismatch repair complex
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0030983 - mismatched DNA binding [Evidence
                     IEA];
                     GO_process: GO:0006298 - mismatch repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HIN4237466.1"
                     /translation="IPATSPVGTKVCVEDLFFNTPARLKYMKSQQAELSHIIDIVNRL
                     GLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGF
                     VSLPELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYL
                     ADVNVHPTKQEVRISKEKELMTLVSEAIANSLKEQTLIPDALENLAKSTVRNREKVEQ
                     TILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLDRLTKPAKLHF
                     AERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGL
                     YIIDQHAAQERVKYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVG
                     VFLAEYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTKEVSIKKYRAELAIMMSCK
                     RSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENHTS
                     LRELGKY"
     gene            complement(1873..2340)
                     /gene="ribH"
                     /locus_tag="AC0DU4_001520"
     CDS             complement(1873..2340)
                     /gene="ribH"
                     /locus_tag="AC0DU4_001520"
                     /EC_number="2.5.1.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009349 - riboflavin synthase complex
                     [Evidence IEA];
                     GO_function: GO:0000906 - 6,7-dimethyl-8-ribityllumazine
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="HIN4237467.1"
                     /translation="MNTYEGNLVANNIKIGIVVARFNEFITSKLLSGALDNLKRENVN
                     EKDIEVAWVPGAFEIPLIASKMAKSKKYDAIICLGAVIRGNTSHYDYVCSEVSKGIAQ
                     ISLNSEIPVMFGVLTTDTIEQAIERAGTKAGNKGSECAQGAIEMVNLIRTLDA"
     gene            complement(2341..3546)
                     /locus_tag="AC0DU4_001521"
     CDS             complement(2341..3546)
                     /locus_tag="AC0DU4_001521"
                     /EC_number="3.5.4.25"
                     /EC_number="4.1.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003935 - GTP cyclohydrolase II activity
                     [Evidence IEA];
                     GO_function: GO:0008686 -
                     3,4-dihydroxy-2-butanone-4-phosphate synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP
                     cyclohydrolase II"
                     /protein_id="HIN4237468.1"
                     /translation="MEYRKIQEALEALQKGRLVLVIDDKDRENEGDLICSAQAATTEN
                     VNFMATYAKGLICMPMSESLANQLMLSPMVENNTDNHKTAFTVSIDYKETTTGISAEE
                     RGLTARMCVAEDITPSDFRRPGHMFPLIAKKGGVLERNGHTEATVDLLKLAGLKECGL
                     CCEIMNHDGKMMRTDDLIQFSKKHNIPLITIKELQEYRKVYDQLVERVSTVNMPTRYG
                     NFKAISYIDKLNGEHHLALIMGNIEDEANVLCRVHSECLTGDVLGSLRCDCGQQFDKA
                     MKMIVENGSGVLLYLRQEGRGIGLINKLKAYHLQDQGMDTLDANLALGFEGDLREYHI
                     GAQMLKDLGLQSLHLLTNNPDKVEQLEKYGITISSRISIEIEANPYDSFYLETKKNRM
                     GHILNMEEK"
     gene            complement(3566..4201)
                     /gene="ribE"
                     /locus_tag="AC0DU4_001522"
     CDS             complement(3566..4201)
                     /gene="ribE"
                     /locus_tag="AC0DU4_001522"
                     /EC_number="2.5.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000493842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004746 - riboflavin synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="riboflavin synthase"
                     /protein_id="HIN4237469.1"
                     /translation="MFTGIIEEIGKVERIQKDSRNCKLSIKASKILTDIHLGDSIAVN
                     GICLTVTHFNHQSFTVDVMNETWSRTALTLLKHGSEVNLERALSVNGRLGGHVVTGHI
                     DGTGKISSIKKDDNAVWYQINTQKEILDLIVEKGSITIDGISLTVAKVSKVNFSVSVI
                     PHTLEQTILKSKQVGSTVNLENDILGKYVQKLMDNSPKSEISKELLYQNGF"
     gene            complement(4186..5286)
                     /gene="ribD"
                     /locus_tag="AC0DU4_001523"
     CDS             complement(4186..5286)
                     /gene="ribD"
                     /locus_tag="AC0DU4_001523"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA];
                     GO_function: GO:0008835 -
                     diaminohydroxyphosphoribosylaminopyrimidine deaminase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /protein_id="HIN4237470.1"
                     /translation="MSDSKYMKLAIKLAQKGAGYVNPNPMVGAVIVKDNHIIGQGYHE
                     FFGGPHAERNALKNCRKSPVGATLYVTLEPCCHFGKTPPCIDAIIDSGITRVVIGSLD
                     CNPIVSGKGVKILEENNLQVTVGILENECLNLIKSFRKYITQHVPYVFMKYAMSMDGK
                     IATKTNQSKWITEEEARKHVHQLRHYVSAIMVGVNTVIQDDPLLTCRLEEGKNPIRII
                     CDTHLRTPLTSKIVKTANDIKTYIATSSEDKNKMKLYQNHGCEILSIKKKGNHIDLSS
                     LMQHLGNMQIDSLVLEGGSLMNWSALEQQIVDELKIYIAPKIFGGSAKFPVGGEGISL
                     PNDAIRLKPYAFSQIGNDYLIESEVIYPCSQE"
     regulatory      complement(5420..5534)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            5691..6284
                     /gene="ruvA"
                     /locus_tag="AC0DU4_001524"
     CDS             5691..6284
                     /gene="ruvA"
                     /locus_tag="AC0DU4_001524"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000271492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009379 - Holliday junction helicase
                     complex [Evidence IEA];
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0009378 - four-way junction helicase
                     activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HIN4237471.1"
                     /translation="MYAYLKGIITKITAKYIVLETNGIGYILHVANPYAYSGQVNQEA
                     QIYVHQVVREDAHLLYGFRSEDEKKLFLSLISVSGIGPVSALAIIAADDNAGLVQAIE
                     TKNITYLTKFPKIGKKTAQQMVLDLEGKVVVAGDDLPAKVAVQASAENQELEEAMEAM
                     LALGYKATELKKIKKFFEGTTDTAENYIKSALKMLVK"
     gene            6294..6857
                     /locus_tag="AC0DU4_001525"
     CDS             6294..6857
                     /locus_tag="AC0DU4_001525"
                     /EC_number="3.2.2.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008725 - DNA-3-methyladenine glycosylase
                     activity [Evidence IEA];
                     GO_process: GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase I"
                     /protein_id="HIN4237472.1"
                     /translation="MTKRCSWVKMTNPLYITYHDEEWGQPLHDDQALFELLCMETYQA
                     GLSWETVLNKRQAFREAFHSYQIHSVAEMTDTELEAMLENPAIIRNRAKIFATRANAQ
                     AFLQLQAEYGSFDAYLWSFVEGKTVVNDVPDYRQAPAKTPLSEKLAKDLKKRGFKFTG
                     PVAVLSFLQAAGLVDDHENDCEWKGLK"
     gene            6854..7531
                     /locus_tag="AC0DU4_001526"
     CDS             6854..7531
                     /locus_tag="AC0DU4_001526"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000987430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
                     /protein_id="HIN4237473.1"
                     /translation="MMSNKNKGILIFAILYTVLFVFDGVKLLASLMPSAIANYLVYVV
                     LALYGSFLFKDRLIQQWKEIRKTKRKFFFGVLTGWLFLILMTVVFEFVSEMLKQFVGL
                     DGQGLNQSNIQSTFQEQPLLIAVFACVIGPLVEELFFRQVLLHYLQERLSGLLSIILV
                     GLVFALIHMHSLALSEWIGAVGYLGGGLAFSIIYVKEKENIYYPLLVHMLSNSLSLII
                     LAISIVK"
     gene            complement(7668..8698)
                     /locus_tag="AC0DU4_001527"
                     /pseudo
     CDS             complement(7668..8698)
                     /locus_tag="AC0DU4_001527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255096.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008236 - serine-type peptidase activity
                     [Evidence IEA];
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="S66 family peptidase"
     gene            complement(8953..9636)
                     /locus_tag="AC0DU4_001528"
     CDS             complement(8953..9636)
                     /locus_tag="AC0DU4_001528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1129 domain-containing protein"
                     /protein_id="HIN4237474.1"
                     /translation="MSQIDLQKLTKKNQEFVHIATQQFIKDGKTDAEIQTIFEEVIPQ
                     ILEEQSKGTTARSLYGAPTHWAHSFTVKEQYEKEHPKENDDPKLMIMDSALFITSLFA
                     LVSALTTFFAADQAFGYGLITLLLVGLVGGFAFYLMYYFVYQYYGPDMDRSQRPPFWK
                     SVLVILASMFLWLLVFFATSFLPASLNPVLDPLPLAIIGAALLALRFYLKKRLNIRSA
                     SAGPTRYQE"
     gene            complement(9648..10592)
                     /locus_tag="AC0DU4_001529"
     CDS             complement(9648..10592)
                     /locus_tag="AC0DU4_001529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046873 - metal ion transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HIN4237475.1"
                     /translation="MKQVFLSTTTEFKEIDTLEPGTWINLVNPTQNESLEIANTFDID
                     IADLRAPLDAEEMSRITIEDEYTLIIVDVPVTEERNNRTYYVTIPLGIIITEETIITT
                     CLEPLPVLDVFINRRLRNFYTFMRSRFIFQILYRNAELYLTALRSIDRKSEQIESQLH
                     QSTRNEELIELMELEKTIVYFKASLKTNERVIKKLTSSTSNIKKYLEDEDLLEDTLIE
                     TQQAIEMADIYGNVLHSMTETFASIISNNQNNIMKTLALVTIVMSIPTMVFSAYGMNF
                     KDNEIPLNGEPNAFWLIVFIAFAMSVSLTLYLIHKKWF"
     gene            10724..>12273
                     /locus_tag="AC0DU4_001530"
     CDS             10724..>12273
                     /locus_tag="AC0DU4_001530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HIN4237476.1"
                     /translation="MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFD
                     TLYAEGQRRYVESLSAYARQFLGNMEKPDVDAIDGLSPAISIDQKTTSKNPRSTVGTT
                     TEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILASVIRKKK
                     GQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRL
                     FDSIEAALRIAEGYVIIDTMDDSELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCS
                     ECDGLGIKLEVDTDLVVPDASKTLREGALAPWNPISSNYYPNMLEQAMKVFGVAMDKP
                     FEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYT
                     RTQMRLYMNELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTL
                     SENEAIIARPILKEIKDRLTFLNNVGLNYLTLSRSAGTLSGGESQRIRLATQIGSNLS
                     GVLYILDEP"
BASE COUNT         3467 a         2447 c         2514 g         3845 t
ORIGIN      
        1 atcccagcga ctagtcctgt gggaaccaag gtttgtgtgg aggatctctt tttcaacacg
       61 cctgcccgtc tcaagtatat gaagagccag caagcggagt tgtctcatat cattgatatt
      121 gtcaaccgtc tgggcttggc ccatcctgag atttctttta gcttgattag tgatggcaag
      181 gaaatgacgc ggacagcagg gactggtcaa ttgcgccaag caatcgcagg gatttacggt
      241 ttggtcagtg ccaagaagat gattgaaatt gagaactctg acctagattt cgaaatttca
      301 ggttttgtgt ccttgcctga gttgactcgg gctaaccgca attatatcag cctcttcatc
      361 aatggccgtt atattaagaa cttcctgctc aatcgtgcta ttttggatgg ttttggaagc
      421 aagcttatgg ttggacgttt tccactggct gtcattcaca tccatatcga cccttatcta
      481 gcggatgtca atgtgcatcc aactaagcaa gaggtgcgga tttccaagga aaaagaactg
      541 atgactctgg tttcagaagc tattgcaaat agtctcaagg aacaaacctt gattccagat
      601 gccttggaaa atcttgccaa atcgaccgtg cgcaatcgtg agaaggtgga gcaaactatt
      661 ctcccactca aagaaaatac gctctactat gagaaaactg agccgtcaag acctagtcaa
      721 actgaagtag ctgattatca ggtagaattg actgatgaag ggcaggattt gaccctgttt
      781 gccaaggaaa ccttggaccg attgaccaag ccagcaaaac tgcattttgc agagagaaag
      841 cctgctaact acgaccagct agaccatcca gagttagatc ttgctagcat cgataaggct
      901 tatgacaaac tggagcgaga agaagcatcc agcttcccag agttggagtt tttcggacaa
      961 atgcacggga cttatctctt tgcccaaggg cgagatggac tttacatcat agatcagcac
     1021 gctgctcagg aacgggtcaa gtacgaggag taccgtgaaa gcattggcaa tgttgaccag
     1081 agccagcagc aactcctagt gccctatatc tttgaatttc ctgcggatga tgccctgcgt
     1141 ctcaaggaaa gaatgcctct cttagaggaa gtgggcgtct ttctagcaga gtacggagaa
     1201 aatcaattta ttctacgtga acatcctatt tggatggcag aagaagagat tgaatcaggc
     1261 atctatgaga tgtgcgacat gctccttttg accaaggaag tttctatcaa gaaataccga
     1321 gcagagctgg ctatcatgat gtcttgcaag cgatctatca aggccaatca tcgtattgat
     1381 gatcattcag ctagacaact cctctatcag ctttctcaat gtgacaatcc ctataactgt
     1441 cctcacggac gtcctgtttt ggtgcatttt accaagtcgg atatggaaaa gatgttccga
     1501 cgtattcagg aaaatcacac cagtctccgt gagttgggga aatattaaaa gtataaaaaa
     1561 gtctgggaaa aattttcaaa atcagaaaaa cgcataaaat caggtgttca aaaaccttga
     1621 ttttatgcgt tttatcatag aaatatttac ttcatttttt cctaattctt ttcgaaactc
     1681 tttttaaacc acgtcagttt tatcagtaat ctcaaaacag tgttttgagc taattttgcc
     1741 agttttgtct gtaacatcga agttgtgttt taccactctg cgactggttt cctagtttgc
     1801 tctatgattt tcacagagta ttaaattgcg attttgccaa gtttctttat tcgtctaaaa
     1861 gtagagtctg ttctatgcgt ctaatgtacg aattaggttg accatttcaa tagctccttg
     1921 tgcacactca gaacccttat ttcctgcttt agtaccagct cgttctatgg cttgttcaat
     1981 tgtatctgtc gttaacacac caaacataac aggaatttcg ctatttaaac tgatttgggc
     2041 gattccctta gatacctcgc tacatacata atcataatga cttgtattcc ctctaatgac
     2101 agctcccaag cagataattg catcatattt tttacttttt gccatttttg atgcaatcag
     2161 tggtatttca aaagctcctg gaacccaggc tacctcgata tctttctcgt ttacattctc
     2221 tcttttgaga ttatctagtg ctccagataa taattttgaa gttataaatt cattaaatct
     2281 cgctacaaca atacctattt taatattgtt tgctactaaa ttaccttcat aagtgttcat
     2341 ttatttttcc tccatattta aaatgtgacc cattcgattt ttctttgttt ctaaataaaa
     2401 actatcgtaa ggattggctt ctatttcgat tgatattcta ctggaaatgg taattccata
     2461 tttttctaac tgttcaacct tgtcaggatt atttgtcagt aaatgaagtg actgaagtcc
     2521 cagatcttta agcatttgtg ctccaatatg atattctctt aaatcacctt caaagcctaa
     2581 tgcaagattg gcatcaagcg tatccatgcc ttgatcttgt aaatgatagg cttttaattt
     2641 attgataagt ccaattcctc gtccctcctg tcgcaagtaa agtaagacac ccgaaccatt
     2701 ctcaacaatc attttcatag ctttatcgaa ttgctgtcca caatcgcaac gtaaagagcc
     2761 taaaacatct cctgttaaac attcggagtg gacccgacat aatacattgg cttcatcctc
     2821 tatgtttccc ataataagag caagatgatg ttccccattt agtttatcta tatagctaat
     2881 tgctttgaaa ttaccgtatc tagtaggcat attgacagtt gaaactcgtt ctaccagctg
     2941 atcatatact tttctatatt cttgtaattc tttgatggta attagtggaa tgttgtgttt
     3001 cttcgagaac tgaattaaat catctgttct catcattttg ccatcatgat tcattatttc
     3061 acaacatagg ccacactctt ttagtccagc taattttaat aaatcaacag ttgcttctgt
     3121 gtgtccattt ctttctagaa caccaccttt ttttgcaatt aaaggaaaca tgtgtcctgg
     3181 cctgcgaaaa tcagagggtg ttatatcttc agctacacac atacgtgcgg tcagtcctct
     3241 ttcctcggca gaaatacctg tggtcgtttc tttataatca attgaaactg taaaagcagt
     3301 cttatgatta tctgtattgt tttcaaccat aggtgaaagc attaattgat tagctaaact
     3361 ttcgctcata ggcatacaaa ttaatccttt ggcataagta gccataaaat taacattttc
     3421 tgttgtagct gcttgtgcag aacaaattaa gtctccttca ttttctctat ccttgtcgtc
     3481 tataacaaga acaagtcgtc ccttctgcaa tgcttctaat gcttcttgta tttttcgata
     3541 ttccattgac tgattatcct ttctgctaaa atccattttg atataatagt tccttagata
     3601 tttctgattt tggagagtta tccatcagtt tttgcacata tttacctaag atatcatttt
     3661 caagatttac tgtactcccg acttgtttac tcttaagaat ggtttgttcc aaggtatgag
     3721 ggataacaga tactgaaaag tttactttgg agactttagc gacagtcaga ctaatgccgt
     3781 caattgtaat agatcctttt tcaactatta aatctaaaat ttctttttgt gtgttgattt
     3841 gataccatac agcattatca tcttttttta ttgacgagat ttttcctgta ccatcaatgt
     3901 gtcctgtaac gacgtgaccc ccaagtcgac cgttgacaga taaggctctt tctagattca
     3961 cctcacttcc atgttttaat agagtaagag ctgttcgact ccatgtttca ttcattacat
     4021 caactgtaaa ggattgatga ttgaaatgag taactgtaag acagatacca tttactgcta
     4081 tactatcgcc taaatggata tccgttaata tttttgaggc tttaattgat agtttacaat
     4141 tacgagagtc tttctgtatt ctttcaactt ttccgatttc ttcaattatt cctgtgaaca
     4201 tggataaatc acttcacttt ctatgagata gtcatttcct atttgagaaa aagcataagg
     4261 tttcaatcta atagcgtcat ttggcaaaga aatgccttca cctccgacag gaaacttggc
     4321 actgcctcca aaaatttttg gtgcaatata tattttcagc tcatcaacaa tttgttgttc
     4381 caaagcactc caattcatta gactgccccc ttctagaact aggctatcaa tctgcatgtt
     4441 tcctagatgt tgcattaaac tcgataagtc tatatgattg ccttttttct ttatggaaag
     4501 tatttcacag ccatgatttt gatatagctt cattttattt ttgtcttcag aggaagtggc
     4561 aatgtaagtt ttaatatcat ttgctgtttt tacgatttta gaggtaagag gagttcgtaa
     4621 atgtgtatcg catatgatac ggataggatt tttcccttcc tccaatctac atgtcagcaa
     4681 aggatcgtct tgaataacag tattgactcc caccataatt gcactaacat agtgtcgtaa
     4741 ctgatgcaca tgctttcttg cttcttcttc agtaatccat ttggattgat ttgttttagt
     4801 ggctattttt ccatccattg acattgcata tttcataaaa acatagggta catgctgggt
     4861 aatatacttt ctaaaacttt ttattaagtt aagacactca ttttctaaaa ttccaacagt
     4921 aacttgaaga ttattttcct caagtatctt tactcctttt ccagatacaa taggattaca
     4981 gtctaggctt ccaatgacta ctcttgtaat accactatcg attatagcat ctatacaggg
     5041 aggtgttttc ccgaagtgac aacagggttc aagtgttaca taaagcgtcg ctccgacagg
     5101 ggattttcta cagtttttaa gagcatttct ctcagcatgt gggccaccaa aaaactcatg
     5161 ataaccttgt ccgataatgt gattatcttt tacaataact gcgccgacca taggattggg
     5221 attgacgtaa ccagcccctt tttgtgccag ttttattgct aatttcatat attttgaatc
     5281 gctcatctca ctacctccaa aaaaatatac cttgaatagg ggactactca aggcatacaa
     5341 aagaaaactt atgcgattaa caaaaatgct ctgaaatgac aagtaatcat ttcagagcac
     5401 gcaaaaagca caaatatact tttatcttct ttcatccaga ctatactgtc ggctttggaa
     5461 tttcaccaaa tcatgccttt cggctcgtgg gctataccac cggtagggaa ttgcaccctg
     5521 ccctgaagat agttattcaa ttacagatga ttatagtact taattttgaa tatgtcaaca
     5581 gataaatacc gattgttttt gatatactgt atttgtgata atcgattctc gctcctcgga
     5641 taaagaaaat atgatatact agataaacga aataagagag aaggaacact atgtacgcat
     5701 atttaaaagg aatcattacc aaaattactg ccaaatacat tgttcttgaa accaatggta
     5761 ttggttatat cctgcatgtg gccaatcctt atgcctattc aggtcaggtt aatcaggagg
     5821 ctcagattta tgtgcatcag gttgtgcgtg aggacgccca tttgctttat ggatttcgct
     5881 cagaggatga gaaaaagctc tttcttagtc tgatttcggt ctctgggatt ggtcctgtat
     5941 cagctcttgc tattatcgct gctgatgaca atgctggctt ggttcaagcc attgaaacca
     6001 agaacatcac ctacttgacc aagttcccta aaattggcaa gaaaacagcc cagcagatgg
     6061 tgctggactt ggaaggcaag gtagtagttg caggagatga ccttcctgcc aaggtcgcag
     6121 tgcaagcaag tgctgaaaac caagaattgg aagaagctat ggaagccatg ttggctctgg
     6181 gctacaaggc aacagagctc aagaaaatca agaaattctt tgaaggaacg acagatacag
     6241 ctgagaacta tatcaagtcg gcccttaaaa tgttggtcaa ataggagcag agaatgacaa
     6301 aacgttgttc gtgggtcaag atgaccaacc cgctctacat cacctatcat gatgaggagt
     6361 ggggccagcc cctccatgat gaccaagcat tgtttgagtt gttgtgtatg gaaacctatc
     6421 aggcaggcct gtcttgggaa acggtactca acaaacgcca agctttccga gaagcctttc
     6481 atagctatca aattcactca gtcgcagaga tgactgacac tgaattggaa gccatgctgg
     6541 agaatccagc tatcattcga aatagagcca agatttttgc tacacgcgct aacgcccaag
     6601 cctttctaca gttacaggca gagtacggct cttttgatgc ctatctttgg tcttttgttg
     6661 aggggaaaac tgtcgttaac gatgttcctg attatcgcca agccccagct aaaacaccct
     6721 tatctgagaa attagccaaa gatctcaaaa aacgaggctt caagttcaca ggcccagtcg
     6781 ccgtattgtc ttttctacag gctgcagggc tagttgatga ccacgagaat gattgtgagt
     6841 ggaaaggtct taaatgatgt ctaacaaaaa taagggaatt ctgatttttg cgattctcta
     6901 tacagtcctc tttgtgtttg atggcgttaa attgctggct tctttaatgc catctgccat
     6961 tgcaaattat cttgtttatg tagttttagc tttatatggc tccttcttgt tcaaggatag
     7021 attgatccaa caatggaagg agattagaaa gactaaaaga aaattcttct ttggagtctt
     7081 aacaggatgg ctctttctca ttctgatgac tgttgtcttt gaatttgtat cagagatgtt
     7141 gaagcagttt gtgggactag atggacaagg tctaaatcag tctaatattc aaagtacctt
     7201 tcaagaacaa ccactactga tagctgtttt tgcttgtgtc attggacctc tggtagaaga
     7261 attatttttc cgtcaggtct tattgcatta cttgcaggaa cggttgtcag gtttactaag
     7321 cattattctg gtaggacttg tttttgctct gattcatatg cacagtttgg ctctatcaga
     7381 gtggattggt gcagttggtt acttaggtgg aggccttgcc ttttctatta tttatgtgaa
     7441 agaaaaagag aatatctact atcccctact tgttcacatg ttaagcaaca gcctctcctt
     7501 aatcatttta gctatcagta tagtaaaatg aaatgagaac aggacaaatc gatttctaac
     7561 aatgttttag aagtagaggt gtactattct agtttcaata tactgtaata tgtgatgaaa
     7621 atgccagtaa tgataccgag aaaaaagctg agaaactttt cccagcttta tttgttatag
     7681 tcaaagagaa tgacttgttc ctgtgcatct acatgagcat ggaccccaaa gggtacaatt
     7741 gctcttggag ttgcgtggcc gacattcaga ttatagacaa tcgggatatt gctgtcaatg
     7801 atatccaata gtgcctcttt atagtcgtca tggaaagttt catccatagg ttttccgacc
     7861 aagagtccat tgatgaccgc gaatatgcca gtgtccttta aagttagcaa catctttttg
     7921 aagtcttctg gcttaggctt ttcttcgctt gtttcgagca agaggatttt cccttcccag
     7981 tctgacaagt cagggaaaag tttgtatttt tggcagagtt ccgtgctatc tgcgtatcga
     8041 gagttgtcaa agatatcgta gagggattcg aggcaaccac cgaggatttt cccctcgaac
     8101 tgggcacttc cttgcaacaa gtcaaaacct gtatttgtat gactgacacg aggtgttccc
     8161 agggccgtgg gactaaaatc agttcgttcc tcataccaaa cgtcactagg gcggatttct
     8221 gaaattcttc ccgtctcaat caattcttta aagtagtgaa ggctataggc tagcatttct
     8281 ttgtctaatt cacaaatgtc tgctaaaaag gattgaccat aaaaagtctt gattcctaat
     8341 ttatgcaaca tgaggtggtt catggttgta tccgagaagc caagaaaaat tttttgtttg
     8401 ataccctttt ggagttggtc attttcaaaa agataaggta gcaagcgata ggcatcgtct
     8461 ccaccgatgg cacataggat catgtcgatc tatcatcaga aaaggcatga atcaaatcct
     8521 ctgcacgagc ttcaggatgg tccttgataa agtctaatcc ttttaacgaa tggggcaaaa
     8581 agatgggatt gagtcccaga tccttgagac gttggatacc caagtccact tcgtgtttga
     8641 caaaatcctc tccgataatg ccactagata aactaacaat accaatagta gaaaccatat
     8701 ctcatcctcc tagaaataga ttgagcctat tttatcacaa aatataagag aaagctatgt
     8761 gggatttcag aagaatactt ttaatactct tcgaaaatct cttcaaacca cgtcagtttt
     8821 atttgcaacc tcaaagctgt gctttgagca acctgcagct agcttcctag tttgctcttt
     8881 gattttcatt gagtataact caaaaaagta agtgaaaaag caaccgcacc tgcagttgct
     8941 tttatcgttt tcttattctt gatagcgtgt tggtcctgca cttgcactac ggatattcaa
     9001 gcgtttcttg agatagaagc gaagggctag gagggctgct ccaataatag ctagtggcaa
     9061 tggatccagt actgggttaa ggctagctgg taggaagctt gttgcaaaga agacaagcaa
     9121 ccaaaggaac atagaagcta ggataactag tacagatttc cagaaaggtg gacgttgact
     9181 gcgatccata tctggtccat agtattggta aacaaagtag tacatcaagt agaaggcaaa
     9241 tccaccaacc agtccaacta atagaagagt aatcaatcca tagccgaaag cttgatctgc
     9301 cgcaaagaag gttgtgaggg cgctgacaag ggcaaagagg ctagtgatga aaagagctga
     9361 gtccataatc atcagttttg gatcatcatt ttcttttgga tgctcttttt cgtactgctc
     9421 tttgacagtg aagctatgag cccaatgagt tggtgcgccg tatagggaac gggcagttgt
     9481 acctttagat tgctcctcaa ggatttgggg aatgacttcc tcaaaaatag tctggatttc
     9541 agcgtctgtt ttcccatctt tgatgaattg ttgggtagca atgtggacaa actcttggtt
     9601 tttcttagtt aatttttgta gatcaatttg agacatagga actcctctta gaaccatttt
     9661 ttatggatga gatagagagt gagcgagaca ctcatagcaa aggcgataaa gacgattaac
     9721 cagaaggcat ttggctctcc gtttaggggg atttcattat ccttaaagtt catcccgtag
     9781 gcagaaaaga ccatggttgg gatggacatg acgatggtca caagggccaa ggttttcatg
     9841 atgttgttct ggttgttaga aatgatagag gcaaaggtct ctgtcataga atgcaagacg
     9901 tttccataaa tatctgccat ctcgatggcc tgttgggttt caatcagggt gtcttcaagc
     9961 aggtcttcgt cttcaaggta tttcttgata ttgctggttg aactggtcaa tttcttaatc
    10021 acgcgctcat ttgttttgag ggaggccttg aaatagacga tagttttttc caattccatg
    10081 agctcaatca attcttcatt acgagttgat tgatgcagtt gactttcgat ttgttcactc
    10141 ttgcggtcga ttgaacgaag ggctgttagg taaagctctg cattgcgata aagaatttga
    10201 aagataaaac gtgaacgcat gaaggtatag aaattacgca atcgacggtt gataaagaca
    10261 tcaaggacag gtagtggttc caaacacgta gtgataatgg tttcctcagt gatgataata
    10321 ccaagcggga tggttacgta gtaggtgcgg ttatttcttt cctccgtgac cggcacgtct
    10381 acgataatca gggtatactc gtcttcaatg gtaatacgag acatttcttc cgcatcgagc
    10441 ggtgctcgaa ggtcggcaat atcaatatcg aaggtgttgg cgatttcgag tgattcattt
    10501 tgagtcggat tgacgagatt gatccaagta cccggttcaa gcgtatcgat ctctttaaat
    10561 tcagttgttg tagagagaaa aacttgtttc atatccctta tcctttctca tttttcagat
    10621 tttttcacac tgtactatta tactacaaaa tcggcctttt gggtaataga atctcacttt
    10681 ttttggtata atggtaagca ataatggact agaaagaaca aagatgcaag ataaaattgt
    10741 cattcatggg gcgcgtgccc ataatttaaa aaatattgat gtggagattc cgcgagacaa
    10801 gttggttgtc gtgactggct tgtcaggttc agggaagtcc agtctggctt ttgataccct
    10861 ctatgcggag ggacaacgtc gctatgtaga gagtttgtcc gcctacgctc gtcagttctt
    10921 gggaaatatg gaaaaaccag atgtagatgc cattgatggt ctcagtccag ctatttctat
    10981 cgaccagaaa acgactagca aaaaccctcg ctcgacggtg ggaacaacga ctgaaatcaa
    11041 tgactatctg cgtctcctct acgcacgtgt ggggacgcct tactgtatca acggacatgg
    11101 agctatcaat gcttcttctg tggagcaaat cgttgataag gttttggagt tacctgaacg
    11161 ccagcgcttg cagatcttgg cctctgtcat ccgcaagaaa aaaggccaac ataagagtgt
    11221 tatcgagaag gttcagaaag acgggtatgt tcgtgtccgt gtggatgggg aagtctatga
    11281 tgtgaccgaa gtgccagagt tgtctaagag caagcaacac aatatcgatg tcgtggttga
    11341 ccgtattgtt atcaaggagg gcattcgtag tcgtctcttt gattccattg aggctgccct
    11401 tcgtattgca gaaggttatg tcattatcga caccatggac gactctgagt tgttgttctc
    11461 tgagcattat gcctgtccag tttgtggttt tactgtccca gagttagagc ctcgtctctt
    11521 ctctttcaat gctccttttg gctcttgtag tgagtgtgac ggcttgggca tcaagctgga
    11581 ggtggatact gatttggtag tgccagatgc cagcaaaacc ttacgtgagg gagcgttagc
    11641 accttggaat cctatctcat ccaactacta tccaaacatg ttagagcagg ccatgaaagt
    11701 atttggagtg gctatggata agccttttga ggacctgtca gaagaagata agaacttgat
    11761 tctctatggg tcagatggta aggaattcca tttccactat gagaatgaat ttggtggcgt
    11821 gcgcgatatc gacattccgt ttgagggagt tatcaataat atcaaacgtc gttaccatga
    11881 aaccaatagc gattacactc gcactcagat gcgtctctac atgaatgagc tgacctgcgg
    11941 aacctgtcaa ggctatcgtc tcaatgacca ggccttgtct gtccgtgtgg gcggccagca
    12001 agggccacat attggagaaa tctcagacct gtctatcgct gaccacttgg acttggtgag
    12061 ccagttaact ttgtctgaaa atgaagccat cattgctcgt cccattctca aggaaatcaa
    12121 ggatcgtttg accttcctta ataatgtggg tcttaactat ctaaccctgt cacgttcagc
    12181 aggaaccctt tcaggtgggg aaagtcagcg cattcgtttg gcaacccaga ttggttccaa
    12241 cctatcaggc gtcctctata tcctagacga gcc
//
LOCUS       DBMVGT010000050        12123 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.050, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000050 DBMVGT010000000
VERSION     DBMVGT010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 12123)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12123)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12123
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.050"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..419)
                     /locus_tag="AC0DU4_001531"
     CDS             complement(<1..419)
                     /locus_tag="AC0DU4_001531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HIN4237477.1"
                     /translation="MAYTLKPEEVGVFAIGGLGEIGKNTYGIEYQDEIIIVDAGIKFP
                     EDDLLGIDYVIPDYSYIVDNIDRVKAVLITHGHEDHIGGIPFLLKQANVPIYAGPLAL
                     ALIRGKLEEHGLLRNAKLYEINHNTELTFKNLKATFF"
     gene            complement(421..654)
                     /locus_tag="AC0DU4_001532"
     CDS             complement(421..654)
                     /locus_tag="AC0DU4_001532"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002947111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003899 - DNA-directed RNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-dependent RNA polymerase subunit epsilon"
                     /protein_id="HIN4237478.1"
                     /translation="MIYKVFYQETKERSPRRETTRALYLDIDASSELEGRITARQLVE
                     ENRPEYNIEYIELLSDKLLDYEKETGAFEITEF"
     gene            934..1149
                     /locus_tag="AC0DU4_001533"
                     /pseudo
     CDS             934..1149
                     /locus_tag="AC0DU4_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282487.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(1472..1624)
                     /gene="cibB"
                     /locus_tag="AC0DU4_001534"
     CDS             complement(1472..1624)
                     /gene="cibB"
                     /locus_tag="AC0DU4_001534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibB"
                     /protein_id="HIN4237479.1"
                     /translation="MMKDLNNYREISNKELQEIKGGFGVGVGIALFMAGYTIGKDLRK
                     KFGKSC"
     gene            complement(1626..1811)
                     /gene="cibA"
                     /locus_tag="AC0DU4_001535"
     CDS             complement(1626..1811)
                     /gene="cibA"
                     /locus_tag="AC0DU4_001535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000180803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibA"
                     /protein_id="HIN4237480.1"
                     /translation="MTNFDILDNQFLSLSENELSDIDGGLAPLVIFGVAVSWKAIAGG
                     TALIGSGLAAGYFLGGD"
     gene            1989..2672
                     /gene="tsaB"
                     /locus_tag="AC0DU4_001536"
     CDS             1989..2672
                     /gene="tsaB"
                     /locus_tag="AC0DU4_001536"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HIN4237481.1"
                     /translation="MKVLAFDTSSKALSLAILEDKQVLAETTINIKKNHSITLMPAID
                     FLMASLDWTPKDLDRIVVAEGPGSYTGLRIAVATAKTLAYTLNIELVGMSSLLALVPY
                     QQEGLFVPLMDARRNNVYAGFYENAKPVMAEAHLPFERVIELIKGASQVTFVGEVGPF
                     VEQIQKHLPRTDYKETLPNAANLALLAWDKEADSLHDFVPNYLKRVEAEENWLKNHTE
                     SGESYIKRL"
     gene            2669..3106
                     /gene="rimI"
                     /locus_tag="AC0DU4_001537"
     CDS             2669..3106
                     /gene="rimI"
                     /locus_tag="AC0DU4_001537"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008999 - protein-N-terminal-alanine
                     acetyltransferase activity [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HIN4237482.1"
                     /translation="MIEIKRIQQQPALAQDIYAVMAAVYPVSPWTLEQIQADLSQDQT
                     WYALAYDGAEVIGFLTVQETLFEAEVLQIAVKGACQGQGIASALFAQLPTDKEIFLEV
                     RQSNQRAQAFYKKEKMAVIAERKAYYHDPVEDAIIMKREIDEG"
     gene            3096..4106
                     /gene="tsaD"
                     /locus_tag="AC0DU4_001538"
     CDS             3096..4106
                     /gene="tsaD"
                     /locus_tag="AC0DU4_001538"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HIN4237483.1"
                     /translation="MKDRYILAFETSCDETSVAVLKNDDELLSNVIASQIESHKRFGG
                     VVPEVASRHHVEVITACIEEALAEAGITEEDVTAVAVTYGPGLVGALLVGLSAAKAFA
                     WAHGLPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSEAGDYKIVGETR
                     DDAVGEAYDKVGRVMGLTYPAGREIDELAHQGQDIYDFPRAMIKEDNLEFSFSGLKSA
                     FINLYHNAEQKGESLSTEDLCASFQAAVMDILMAKTKKALEKYPVKTLVVAGGVAANK
                     GLRERLAAEITDVKVIIPPLRLCGDNAGMIAYASVSEWNKENFAGWDLNAKPSLAFDT
                     ME"
     gene            complement(4146..5452)
                     /locus_tag="AC0DU4_001539"
                     /pseudo
     CDS             complement(4146..5452)
                     /locus_tag="AC0DU4_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011680908.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(5788..6079)
                     /locus_tag="AC0DU4_001540"
                     /pseudo
     CDS             complement(5788..6079)
                     /locus_tag="AC0DU4_001540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA];
                     GO_process: GO:0015074 - DNA integration [Evidence IEA];
                     GO_process: GO:0032196 - transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(6188..6479)
                     /locus_tag="AC0DU4_001541"
                     /pseudo
     CDS             complement(6188..6479)
                     /locus_tag="AC0DU4_001541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558102.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 transposase-related protein"
     gene            6722..7276
                     /locus_tag="AC0DU4_001542"
     CDS             6722..7276
                     /locus_tag="AC0DU4_001542"
                     /inference="COORDINATES: protein motif:HMM:NF024831.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HIN4237484.1"
                     /translation="MQYSCGKININIPDGYGDIKDIVFSAHIIVRYNNGHCGGIDPHI
                     IGLCKKQIRRMSLYPILIIVSRDSKVIDDYKNLDIAYVDCTQCSNNFETALHVKNILK
                     LLKIQLIHCHGYSTNYFLYMLKKLDKNGFGKVKTVITCHGWVEYNLKKKFLTYFDFWT
                     YSMGDAFICVSETMKKRLESIIKK"
     gene            7404..7928
                     /locus_tag="AC0DU4_001543"
     CDS             7404..7928
                     /locus_tag="AC0DU4_001543"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: protein motif:HMM:NF012744.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HIN4237485.1"
                     /translation="MDPEKRPDRFLEFAEKLFLVREDVIFIMAGNGSMWAALKEKICH
                     LKCRDNFRLLGEIYPATIVYQISDLLYISSDTEGIPMCVLESMSQGTSVLASNVGGLS
                     EIIEHRVDGFLFEKEDVEGVCACANFLLNDSEYLKYIGENSKSKIRKHFSVQKMFVET
                     MRVYDELLEKSSHG"
     gene            7921..8794
                     /locus_tag="AC0DU4_001544"
                     /pseudo
     CDS             7921..8794
                     /locus_tag="AC0DU4_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397244.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
     gene            8804..10420
                     /locus_tag="AC0DU4_001545"
     CDS             8804..10420
                     /locus_tag="AC0DU4_001545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288036.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4237486.1"
                     /translation="MYTIIKSNIKKFSLLTIFIVAGQLLLIYAATINALVLNELIAMN
                     LERFLKLSIYQMIVWCGIIFLDWVVKNYQVEVIQEFNLEIRNRIATDISNSTYQEFHS
                     KSSGTYLSWLNNDVQTLNDQAFKQLFLVIKGISGTIFAVVTLNHYHWSLTVATLFSLM
                     IMLLVPKIFASKMREVSLNLTNQNEAFLKSSETILNGFDVLASLNLLYVLPKKIKEAG
                     ILLKMVIQRKTTVETLAGAISFFLNIFFQISLVFLTGYLAIKGIVKIGTIEAIGALTG
                     VIFTALGELGGQLSSIIGTKPIFLKLYSINPIESNKMNDIEPNEVNRDFPLYEAKNIC
                     YKYGDKEILKNLNFCFQRNEKYLILGESGSGKSTLLKLLNGFLRDYSGELRFCGDDIK
                     KTSYLNMVSNVLYVDQKAYLFEGTIRDNILLEENYTDEEILQSLEQVGLSVKDFPNNI
                     LDYYVGDDGRLLSGGQKQKITLARGLIRNKKIVLIDEGTSAIDRRTSLAIERKILDRE
                     DLTVIIVTHAPHPELKQYFTKIYQFPKDFI"
     gene            10726..11118
                     /locus_tag="AC0DU4_001546"
     CDS             10726..11118
                     /locus_tag="AC0DU4_001546"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237487.1"
                     /translation="MEIEKNFIDFCYKNMDLILKTQSISLCHREELIIVDVSDDSKFG
                     VFYKRFRTLVDKNNGKYVCVYNFSRVSDILQNWKNYCNRKFSVTFTESQFELFKLLYN
                     QKNFKTISLLFGKKLLLEELSIIAILLI"
     gene            11314..11640
                     /locus_tag="AC0DU4_001547"
     CDS             11314..11640
                     /locus_tag="AC0DU4_001547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237488.1"
                     /translation="MENTLLNITGSFDMETRNLISYSLTDIFETDKIRIELLGEIYYK
                     NIKLELHEFAGLYKIYGISLIKNITGMFLIIIFDTKTKELKIFQDITTSYFNLYYTVY
                     GGVFYI"
     gene            11660..>12123
                     /locus_tag="AC0DU4_001548"
     CDS             11660..>12123
                     /locus_tag="AC0DU4_001548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777224.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA];
                     GO_process: GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine synthase-related protein"
                     /protein_id="HIN4237489.1"
                     /translation="MKLSHVPVTLNNKKIQEFMRNGFILDSNTLVTEINKLEYFSYIS
                     VNNTIRICGIDYNDSNNFTKEQVLKNWDSMLRESILRVYSEAGEANITLSSGFDSNYI
                     LYTLANYTNSSINAFCIGGEKGINEIPEVTKIAKFYGINLLVDTVMSQDLES"
BASE COUNT         3890 a         1848 c         2467 g         3918 t
ORIGIN      
        1 ctaaagaaag ttgccttgag atttttaaag gtcaactcgg tgttgtggtt gatttcgtaa
       61 agtttggcgt tgcgcaagag gccgtgttct tcgagtttcc cacggatcaa agccaaggca
      121 agcggtccag cataaatagg gacatttgct tgcttgagta ggaacggaat cccaccaatg
      181 tggtcctcgt gtccgtgtgt gattaaaaca gccttgacgc ggtcgatatt gtctacgatg
      241 taagagtagt caggaatgac atagtcgata ccaagcaagt catcttctgg gaatttaatc
      301 ccagcatcga cgatgataat ctcgtcttgg tattcaattc cgtaagtgtt tttcccgatt
      361 tctcctagac caccgatggc aaaaacgccg acttcttcag gtttaagagt gtaggccata
      421 ttagaactcc gtgatttcga aggcgccagt ttctttttcg taatcgagca atttgtcaga
      481 caagagttcg atatattcga tattgtactc tgggcgattt tcttcgacaa gttggcgagc
      541 agtgatgcga ccctcaagtt ctgagctggc atcgatgtct aggtaaagcg cgcgtgttgt
      601 ttcacggcgt gggctacgtt cttttgtttc ttgataaaaa actttgtaaa tcatatagtt
      661 cctttctatt tacaggtcag cttattccaa acttttagca gatatttgct tgatttcatt
      721 ccattttgtg tctagattga ccttgattcg ttacaattat ttcaattata ccacaaaatg
      781 aaaaattagt aaaagacgga aacgagaaag ttagggggcg atttctttgg taagcgtttg
      841 caaaaataaa gaaaatgtgt tatgttgata acggaagtga agtttattac ttgtcataat
      901 tccatataga ttttaagtca aggaggttgc cctatgtata acttatttgc ttttgctatc
      961 ggagttcgtt tgctagcttt tatcgttttt gttgcttgcg tttatggagg aaatcttcta
     1021 tttgccaaac tggaacgatg acaaaccaag ttcttgtgga aaattacctt tgtgactctc
     1081 tactcgcttt ttctcctcct cgtgacctat gtcgtttggt ttgtatttta ctttggatta
     1141 aatgcttaga tgccctgctt atgctggttt tttttgtttg ggaatgtaga gatagtagat
     1201 ttacgacacg aaaattccac cccatctatc aagatgaggt ggtctttgca tttttctaac
     1261 atgacatgac aatggaattt tcaaagctta ttatttttat gggagtcatt gttctactca
     1321 aaaatagagt tgaagcataa aaataaaaca atacaaacag ataaatcgaa tggtaaaggg
     1381 atggtagtaa tgttcaaatc attgagaatg ctgagcaaac tgtaagagat gaagacaata
     1441 aaatttatcc ttctaaaaat gtgtttctta tctagcatga cttaccaaac tttttacgaa
     1501 ggtcttttcc aatggtataa cctgccataa ataaagcgat accaacaccg acaccaaagc
     1561 cacccttgat ttcttgcaat tccttattag aaatttcacg ataattgttc aaatctttca
     1621 tcatattaat ctcctcctaa aaaataacca gctgccaaac cagaacctat aagtgctgtt
     1681 ccacctgcaa tagccttcca agatactgct actccaaaga taaccaaggg agcgagaccg
     1741 ccatcaatat ctgataattc attttcagat aaggataaaa attgattgtc aagaatgtca
     1801 aaatttgtca ttgaactttc ctcctttttt cttgttcact tttatattcg gaaaagaaaa
     1861 ggaaaagtga gcattttttt aaattatttt tagttaagtg agggcactct tgtctggggg
     1921 caaagaaaat tcccatgtgc cagcttttgt agtataatag taagcagaca aaaagatagg
     1981 aatgtgttat gaaagtatta gcttttgata cgtccagcaa ggctctttct ctggctattt
     2041 tagaggataa gcaggttctt gccgagacga cgattaatat taagaaaaat cacagtatta
     2101 ctcttatgcc tgccatcgat tttttgatgg caagtttgga ttggacaccc aaggatttgg
     2161 accgaatcgt ggtagctgaa gggccgggta gctatacagg cttgcgaatt gcggtagcaa
     2221 ctgctaagac cttagcttac accctgaaca ttgagttggt tggtatgtct agtctcttgg
     2281 ctctagtgcc atatcaacaa gaaggtttgt ttgttccttt gatggatgcg cgtcgcaata
     2341 atgtttatgc aggattttat gaaaatgcca aacctgtcat ggcagaagca catctgcctt
     2401 ttgagcgagt cattgagcta atcaagggcg ctagtcaggt aacctttgtc ggagaagttg
     2461 gcccctttgt tgagcagatt caaaaacact tgccaaggac tgattacaaa gaaacattgc
     2521 ccaatgcagc taatctagct cttttggcct gggacaagga agcagactcc ttgcatgatt
     2581 ttgtgccaaa ttacctcaaa cgtgttgagg cagaggaaaa ctggctcaag aaccataccg
     2641 agtctggtga gtcttacatt aaacgcctat gatagaaatc aaacgtatcc aacagcaacc
     2701 tgccttggct caagatatct acgctgtcat ggcagctgtt tacccagtca gtccttggac
     2761 actagaacaa atccaagcag atctgtccca agaccagact tggtatgctc tggcctatga
     2821 tggggcagaa gtgattggct ttctaactgt tcaggagact ctctttgaag cagaagtcct
     2881 gcaaatcgct gtcaaaggag cctgtcaggg tcagggaatt gcgtcagcct tgtttgctca
     2941 attgccgaca gacaaggaaa ttttcctcga agttagacag tcaaatcaac gagcgcaagc
     3001 attttacaag aaagaaaaaa tggcggtcat cgctgagcga aaagcctact accatgaccc
     3061 agtcgaggac gccattatca tgaagagaga aatagatgaa ggatagatat attttagcat
     3121 ttgagacatc ctgtgatgag accagtgttg ccgtcttgaa aaacgacgat gagctcttgt
     3181 ccaatgtcat tgctagtcaa attgagagtc acaaacgttt tgggggcgta gtgccagaag
     3241 tagccagtcg tcaccatgtc gaggtcatta cagcctgtat cgaggaggcg ctagcagaag
     3301 cagggattac agaagaggac gtgacagctg tggcggttac ctatggaccg ggcttggtcg
     3361 gagccttact agttggtttg tcagctgcca aggcctttgc ttgggcacat ggacttccgc
     3421 tgattcccgt taaccacatg gctggccatc tcatggcggc tcaaagtgtg gaacctttgg
     3481 agtttccctt gctagccctt ttggttagcg gtgggcacac agagttggtt tatgtttcgg
     3541 aggcaggaga ttataagatt gttggggaaa cccgtgatga tgcggttggt gaggcttatg
     3601 ataaggtcgg ccgtgtcatg ggcttgacct atcctgcagg tcgtgagatt gacgagctgg
     3661 ctcatcaggg gcaggatatt tatgatttcc cccgtgccat gattaaggaa gataatctgg
     3721 agttctcctt ctcaggtttg aaatctgcct ttatcaatct ttatcacaat gccgagcaaa
     3781 agggagaaag cctgtctaca gaagatttgt gtgcttcctt ccaagcagca gttatggaca
     3841 ttctcatggc aaaaaccaag aaggctttgg agaaatatcc tgttaaaacc ctggttgtgg
     3901 caggtggtgt ggcagccaat aaaggtctca gagaacgcct agcagccgaa atcacagatg
     3961 tcaaggttat catcccccct ctgcgactct gcggagacaa tgcaggtatg attgcctatg
     4021 ccagcgtcag cgagtggaac aaagaaaact tcgcaggctg ggacctcaat gccaaaccaa
     4081 gtcttgcctt tgataccatg gaataaagag tggctctttg tcaagtgtag tgggtaggcg
     4141 aaaagctaca atctggagag tacgaaattc gtactctctt ttttgatgtt caaagtcatc
     4201 aaaatccgtt ttttaaaatt gttaaagttc cggaaaccaa aggctttgcg cttgataatc
     4261 ttaatcaaat tattggtcgc ttcaagttta gcgttggaat aaggcagctt aagtgcgttg
     4321 ataatcttat ctctatccct taaaaaagtc caaaagaccg tttgaaaaag cggatgaacc
     4381 gttggcagtt cttgctcaat caatccaaag aaatggtcgg cattcttctc ttgaaaatga
     4441 aagagcagga gttgatagag ttcgtagtga acctgtaatc cctcagagta agaaagcagc
     4501 ttatctcgta cttcccgatg ggttaagtgc attcgaaacg tgggctgata gaatcgtttc
     4561 tgacagagct tgaagctata ctggtgtagt aaatcagtcc agtggactga tttagcccga
     4621 gcctagaaac gaaaaagcga gggttccaaa agcgcttgag cgcccgatac tccaaggatt
     4681 ttcggtcaaa ttggttcatg atttggattc gtactcggtt catagctcgg ctcagatgtt
     4741 ggacaatgtg gaagcggtca agaacaatct tcgcctttgg aaagagttgc ttagcgagcc
     4801 gataataagg gctgtacatg tccatggtga tgacctcgac cagctcccga acctctctct
     4861 gatagcgttg gaaatggttt cgaatcaccg catgagttcg cccgtctaaa attgcgagga
     4921 tggatttgga ctcaaaatct tgggcaatga agctcatttt gctctttttg aagctatact
     4981 catcccaact cataactttt ggcaacttgg tccaatcggt ttcaaactta aattccctca
     5041 gttttcggat gacggtggaa gttgagaccg ccaatctgtg ggcaatctca gtcatagact
     5101 gcttttcaag gaggagctga gcgatttttt gtctcaccat gttggaaatc tggcaatttt
     5161 tcttgacaat ggatgtttga gaaacgacca ccttaaggca attcttgcac tgaaagcggc
     5221 gctttttgag atgcagtacc gtgggtaaac cctgacagtc gagaagcgga attttagagg
     5281 ctttctggaa gtcgtatttg atcatcttcc cttgacaatg aggacaagga ggagcggggg
     5341 aatccaactt tgcctgaacg actagatggg tttggtattt cagaacagac aagattttga
     5401 tatttttgtc ttccaatccg agcaaatctg tggtattctt aagttgttcc atatgaaccc
     5461 tttctaatga gttggttaga cgcttttcat tataggtcat atggggcttt ttttctacaa
     5521 gaaacgaccc tataattcct ggggtgggat tacccactac agaaattata gagccaaagc
     5581 attccaaagt cttgtctgac tctggaatgt tttctgttca cagttgtttt gtaactgcct
     5641 aataagtaac cgcgctataa cgaggtatct accgagattg tcaattctcc agtatactgt
     5701 tataaaaaac aaaactggag gattttttta tgtcccccca tcgtcccatc gactgttccg
     5761 tagctgccca ataacggagt atagtcggct gaaacaagaa taggacaaaa gtgcctcaag
     5821 aaaagcatcg taatttgaca atattattct gagatgtttt tgatgtaagc ccatattttc
     5881 tcaatgggat tatactcggg tgaataggta ggaagtggta acagtctatg ccctgctcct
     5941 tacacatgtt cattctgtga aaccttgcat ggtccataat gataagggat ggtgtatcta
     6001 aagtaggtag taagaatttt tggaagcaag cttcgaaaaa gtcactcgtc atcgtatctt
     6061 tataggtcat cggagccata gtatattgaa acaaaaaagg gcattagtac ttctataaca
     6121 gtatcgcaat ctctggtgtg cgttgtctcg atcttaattc aaataattat atcttcttcc
     6181 agagagacta actgcctgct caaggctcga tcatattcga gataaaaata ggtctcaacc
     6241 cctgtctcat aaatataaat aggagtcagg tagcttaagt gattcaattc tttaaggaac
     6301 cgatttactt tttctgggtc ttgttcgcag taggtacggc tcttttttag actatatccc
     6361 atagccttta gagcgtaatg aatagttgtt ggaggacagt tgaattcagc agctatttca
     6421 gtcaaataag catcgggatg agtttcaata tagattttta atttatctct atcaattttt
     6481 tcaattaata gtggaagttt tcttgaagtt agtgtattga aacgttttta tacagtgcta
     6541 aaatttgaag tgtagtgcag atggatttgt aatagtatta tagcaattct ttggagaagg
     6601 tcgagacaag ataaaatagg tatctttgag atataagcat gatttactat aaaattattg
     6661 agttattcat aaaaatttct ctatcaaata tcataatgcg tcgtttaagg agatggttac
     6721 aatgcaatat agttgtggaa aaataaatat taatatccct gatggatatg gagacattaa
     6781 ggatatagtg ttttcggctc atattatagt taggtataat aatggacatt gtggaggtat
     6841 agatccgcat ataattggac tttgtaaaaa gcagatcaga aggatgtctc tatatcctat
     6901 tttgataatc gtatctagag attcaaaggt tattgatgat tataaaaatt tagatattgc
     6961 ctatgttgat tgtactcaat gttcaaataa ttttgaaact gccttacacg ttaaaaatat
     7021 tttaaaatta ttaaaaatcc aacttataca ctgtcatggc tactcaacta attatttttt
     7081 atatatgtta aaaaaacttg acaagaatgg atttggaaag gttaagacag tgataacatg
     7141 ccatggatgg gttgaatata acttaaaaaa gaaattcttg acttattttg atttttggac
     7201 atattctatg ggagatgctt ttatttgtgt atctgaaact atgaaaaaaa gattggagag
     7261 tataataaaa aaataagaag atagttgcaa taaataacgg aattaatgta tcaaatagcg
     7321 atttagatgt agtaggtgtt caagacttta aaaaagaatt ttgtattcca aataacaaaa
     7381 aaatcatttg ttatgttgga aggttggatc cagaaaaaag gccggataga ttccttgaat
     7441 ttgcagaaaa attattttta gtcagagaag atgtgatttt tattatggct ggaaatggta
     7501 gtatgtgggc tgctttgaaa gaaaaaattt gccatttgaa atgtagagat aatttcaggt
     7561 tacttggtga aatctatcca gctactatag tttaccaaat atcggattta ttgtatattt
     7621 cttctgatac agaaggaata cctatgtgtg ttttagagtc aatgtcacaa ggaacttcgg
     7681 ttttagctag taatgttggc gggttaagtg aaattattga acatagggtt gatggatttt
     7741 tatttgagaa ggaagatgtt gagggagtgt gtgcttgtgc taatttttta ctcaatgatt
     7801 ctgagtattt gaaatatata ggtgagaata gtaaatcaaa aataagaaaa catttttctg
     7861 tgcaaaaaat gtttgtagaa accatgagag tatatgatga attattagag aagagtagtc
     7921 atggatagga atatagatca agaattagta agtattataa taccaacaca taataggtat
     7981 gaatctctga ttagagctgt gaaaacttgt ttacatcaaa gttataaaaa tatcgaagtt
     8041 ataattattg atgataatta tagtaatgta aatttaagaa ataaaattat ccatcaattt
     8101 ggctatacca atcatagaat taagttaatt ttaagtaatg aagatttagg tgcaactaat
     8161 gccagaaaca taggtatcaa aaattctaga ggtaagtata tatcattttt agacgatgat
     8221 gatgaatata tgccagatcg aattttaaag ttgatggctt gttttaaaaa gagtagaatg
     8281 aagaatttag ctttagttta tagttatgga ataataattt atccaaatgg tacacgagaa
     8341 gaggagaaga ccgattttgt tggaaatccc ttgtttgttc aaatggttca catcaggacg
     8401 gtgttgtttt attaaaacta cttgctcaag gataccaaat tgatatagtg cgagaattct
     8461 tggtgaatta ctacgctcac agtaaagaaa acggtatcac tggagtgaca caaaaaacaa
     8521 ttaatgcaga tgaagaatat tataattact gtaggaaata ttttaattta ttgagtttca
     8581 acgagagaat attggttaca aagaaatatt attctttaaa cataaagcgg ttactattaa
     8641 taggagacaa atgcaaggct ttaaaagtaa tcaagaaggc aagagaagaa aaaattttta
     8701 acgaatttct tttttgaaat atatgttatt atatcatttt ggttttttct attgtatata
     8761 tgacaactat gttcaattaa aatttagaaa gtgagaaact attgtgtata ctattataaa
     8821 atcaaatata aaaaaattta gtttattaac gatatttatt gttgctggtc aattattgct
     8881 aatttatgca gcaactatta atgctctggt gttgaatgaa ttaattgcga tgaatttaga
     8941 gcggtttttg aaattgtcaa tctaccaaat gattgtctgg tgtgggataa tattccttga
     9001 ctgggtagtg aaaaattatc aggttgaagt gatccaagag tttaatctag agattcgaaa
     9061 tagaattgcc acagacatct ctaactctac ctatcaagaa tttcatagta aatcatcagg
     9121 aacatatctt tcgtggctaa ataatgatgt tcagacttta aatgatcagg cttttaaaca
     9181 acttttttta gtaataaaag gaatttctgg tactatattt gcagttgtga ctcttaatca
     9241 ctatcattgg tcattgactg tagccacctt gttttcatta atgattatgc tacttgtacc
     9301 aaaaatcttt gcatcgaaaa tgcgagaagt tagtctaaat ttaactaacc aaaatgaagc
     9361 ttttttaaaa tctagtgaga ctatattgaa tggatttgat gtgttagcgt ccttgaatct
     9421 tttatatgta ttgcctaaga aaattaaaga agcaggaatt ttattaaaga tggttataca
     9481 aagaaagaca actgtagaaa cgttagcagg cgctattagc ttctttctca atattttttt
     9541 tcagatatct ctcgtttttt taacaggcta tcttgcaata aaaggaatag tgaaaattgg
     9601 tactattgaa gcaataggag cactaacagg tgttattttt acagcgctag gtgaattagg
     9661 aggtcaatta tcctctatta ttggtacgaa gcctattttt ttaaaattgt attcaattaa
     9721 tccaattgag tcaaataaaa tgaatgatat cgaaccaaat gaggtgaata gagattttcc
     9781 gttatatgaa gcaaaaaata tttgctataa gtatggagat aaagaaatat taaaaaactt
     9841 aaatttttgt tttcaacgta atgaaaagta tttaatttta ggtgaaagtg gaagcgggaa
     9901 atctacatta ttaaaattat tgaatggctt tttgagagat tatagtggag aattgcgatt
     9961 ctgcggggat gatataaaaa aaacctccta tttaaatatg gtttcgaatg ttctatatgt
    10021 agatcaaaaa gcttatttgt ttgaaggtac gattagagat aatattttat tggaagaaaa
    10081 ttatactgat gaagaaatac tacagtcttt agagcaagtt ggtttgagtg taaaagattt
    10141 tcctaataac attttagatt attatgttgg tgatgatggg agattactgt caggagggca
    10201 gaaacaaaaa attactttag ctagagggct aattagaaat aagaaaatag tattaattga
    10261 cgagggaact tctgctatcg ataggagaac ttcgttagcg attgaacgta agatattaga
    10321 tagagaggat ttgactgtca ttattgttac ccatgctccg catccggaac ttaaacaata
    10381 ttttactaag atatatcaat ttccaaagga ttttatttaa gaatataggg gagggaaaca
    10441 tgagattcta ttgtgaagct tatgaggtaa ttactgaaga gaaaaaagta tactttaatg
    10501 atattgagtt agaagttaag tattcctctg tcgaagaatt gtttataata tgtgagaaat
    10561 tattagataa gaaaaaagta tcattttttt atgtagatga gaaaccctta aggtatctgt
    10621 tatttgacta tatatttcca ctagttctag ctaaaaaaaa atatcccaat cttagatgga
    10681 gtttccaata agcaagttgc tccaacgttg ctgcatcact tttctttgga aattgaaaag
    10741 aattttatcg atttttgcta taaaaatatg gatctcatcc taaaaactca aagtatatct
    10801 ttgtgtcata gagaagagct tattattgta gatgtttcag atgactctaa atttggtgtt
    10861 ttttacaagc gttttagaac actggttgat aaaaataacg gaaaatatgt ttgtgtttat
    10921 aatttcagtc gtgtttcaga tatactgcaa aactggaaaa attattgcaa tcgaaaattt
    10981 tcggttacgt ttactgaaag ccaatttgaa ttatttaagc ttttatataa tcaaaaaaat
    11041 tttaaaacaa tttcgttgct atttggaaaa aaattgttgc tggaggaatt atctattata
    11101 gcgatcttac taatatagaa tacttttgta ttttttggtg ggatagtatg tttgggaaag
    11161 attctattgg aaaatacgta tatgtagaag agattagtag atgtcatttt ttagatagaa
    11221 attattcttt ttgttatggt ttacaagatt ataaaagtaa acttattaaa tattttttag
    11281 aatagttaat ctattcgaga gagataaaga aatatggaaa atactttatt gaatatcaca
    11341 ggaagcttcg atatggaaac taggaatcta attagttatt ctttaactga tatctttgaa
    11401 acagataaaa taagaattga acttcttgga gaaatttatt ataaaaatat aaagttggaa
    11461 ttgcatgaat tcgctggatt gtataagatt tatggaatta gcttaataaa gaatattacc
    11521 ggaatgtttt taattataat ttttgatacg aagacaaaag aattaaaaat ttttcaagat
    11581 ataacgactt catactttaa tttatactat actgtttatg gaggtgtgtt ctatatatag
    11641 tacatcttta aagaaagtga tgaagttatc tcatgttccc gttaccttaa ataacaaaaa
    11701 aatacaagaa tttatgagaa atggatttat tttagattca aatactttag taaccgaaat
    11761 taataaatta gaatatttct cttacatttc tgtaaataat actattcgta tatgtggtat
    11821 tgattataat gattcaaaca attttactaa agaacaagta ttaaagaatt gggactctat
    11881 gctacgtgaa tctatattaa gagtgtatag tgaagcagga gaggctaata ttacactatc
    11941 atctggtttt gattcaaatt atatattata tacattagcg aattatacga attcttcaat
    12001 taatgcattt tgcataggag gagaaaaagg aattaatgag attcctgaag taactaaaat
    12061 tgcaaaattt tatggtataa atttattagt tgatactgta atgagccaag atttagaatc
    12121 cca
//
LOCUS       DBMVGT010000051        11995 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.051, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000051 DBMVGT010000000
VERSION     DBMVGT010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 11995)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11995)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11995
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.051"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..206)
                     /locus_tag="AC0DU4_001549"
     CDS             complement(<1..206)
                     /locus_tag="AC0DU4_001549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000943526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HIN4237490.1"
                     /translation="MLRFPKDFVWGSSTSGPQTEGRVAGDGKGDNLWDYWFQVEPNRY
                     YNGIGSDKTSTFYENWERDIELLL"
     gene            complement(306..2159)
                     /locus_tag="AC0DU4_001550"
     CDS             complement(306..2159)
                     /locus_tag="AC0DU4_001550"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0002161 - aminoacyl-tRNA deacylase
                     activity [Evidence IEA];
                     GO_function: GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0004827 - proline-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006418 - tRNA aminoacylation for protein
                     translation [Evidence IEA];
                     GO_process: GO:0006433 - prolyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HIN4237491.1"
                     /translation="MKQSKMPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLP
                     LANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKS
                     DFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDA
                     YSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSART
                     DLDRWVVLDKSVASFDEIPAEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATN
                     EYKPSNRVVAEEEVTRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVG
                     NDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVR
                     NAVVGANEDGYHLTGVNPGRDFTAEYVDIREVREGEISPDGQGVLNFARGIEIGHIFK
                     LGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRY
                     AWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKF
                     SDSDLIGLPIRITVGKKAADGIVEVKIKATGDTIEVHADNVLETLEILSKK"
     gene            complement(2172..3431)
                     /gene="rseP"
                     /locus_tag="AC0DU4_001551"
     CDS             complement(2172..3431)
                     /gene="rseP"
                     /locus_tag="AC0DU4_001551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HIN4237492.1"
                     /translation="MLGILTFILVFGIIVVVHEFGHFYFAKKSGILVREFAIGMGPKI
                     FAHIGKDGTAYTIRILPLGGYVRMAGWGDDTTEIKTGTPVSLTLADDGKVKRINLSGK
                     KLDQTVLPMQVTQFDFEDKLFIKGLVLEEEKTFAVDHDATVVEADGTEVRIAPLDVQY
                     QNATIWGKLITNFAGPMNNFILGVVVFWVLIFMQGGVRDVDTNQFHIMPQGALAKVGV
                     PETAQITKIGSHEVSNWESLIQAVETETKDKTAPTLDVTISEKGSDKQVTVTPKDSQG
                     RYLLGVQPGGKSDFLSMFVGGFTTAADSALRILSALKNLIFQPDLNKLGGPVAIFKAS
                     SDAAKNGIENILYFLAMISINIGIFNLIPIPALDGGKIVLNILEAIRRKPLKQEIETY
                     VTLAGVVIMVVLMIAVTWNDIMRLFFR"
     gene            complement(3453..4256)
                     /locus_tag="AC0DU4_001552"
     CDS             complement(3453..4256)
                     /locus_tag="AC0DU4_001552"
                     /EC_number="2.7.7.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004605 - phosphatidate
                     cytidylyltransferase activity [Evidence IEA];
                     GO_process: GO:0016024 - CDP-diacylglycerol biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HIN4237493.1"
                     /translation="MTQDLQKRTLFAGIALAIFLPILMIGGLLLQIAIGIIAMLAMHE
                     LLKMRGLETMTMEGLLTLFATFALTIPLENYLTFLPVDGNVVAYSVLISIMLGTTVFS
                     KSYTIEDAVFPLAMSFYVGFGFNALLDARVAGLDKALLALCIVWATDSGAYLVGMNYG
                     KRKLAPRVSPNKTLEGALGGILGAILVTIIFMIVDSTVALPYGIYKMSVFAIFFSIAG
                     QFGDLLESSIKRHFGVKDSGKFIPGHGGVLDRFDSMLLVFPIMHLFGLF"
     gene            complement(4265..5023)
                     /locus_tag="AC0DU4_001553"
     CDS             complement(4265..5023)
                     /locus_tag="AC0DU4_001553"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HIN4237494.1"
                     /translation="MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFG
                     HKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPEL
                     HANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLI
                     SQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYS
                     ELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV"
     gene            complement(5254..5826)
                     /locus_tag="AC0DU4_001554"
                     /pseudo
     CDS             complement(5254..5826)
                     /locus_tag="AC0DU4_001554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001098890.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase family protein"
     gene            complement(5807..6805)
                     /gene="ruvB"
                     /locus_tag="AC0DU4_001555"
     CDS             complement(5807..6805)
                     /gene="ruvB"
                     /locus_tag="AC0DU4_001555"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0009378 - four-way junction helicase
                     activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HIN4237495.1"
                     /translation="MSRILDNEMMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEA
                     AKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELE
                     PGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTR
                     AGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPR
                     IANRLLKRVRDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGG
                     PVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK"
     gene            6939..7031
                     /locus_tag="AC0DU4_001556"
     CDS             6939..7031
                     /locus_tag="AC0DU4_001556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="HIN4237496.1"
                     /translation="MMELVLKTIIGPIVVGVVLRIVDKWLNKDK"
     gene            complement(7846..8262)
                     /locus_tag="AC0DU4_001557"
                     /pseudo
     CDS             complement(7846..8262)
                     /locus_tag="AC0DU4_001557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862593.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            complement(8274..8966)
                     /locus_tag="AC0DU4_001558"
                     /pseudo
     CDS             complement(8274..8966)
                     /locus_tag="AC0DU4_001558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001144882.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
     gene            complement(9266..11767)
                     /gene="leuS"
                     /locus_tag="AC0DU4_001559"
     CDS             complement(9266..11767)
                     /gene="leuS"
                     /locus_tag="AC0DU4_001559"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014639013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004823 - leucine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006429 - leucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HIN4237497.1"
                     /translation="MSFYNHKEIEPKWQGYWAEHHTFKTGTDTSKPKFYALDMFPYPS
                     GVGLHVGHPEGYTATDILSRYKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTA
                     ENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
                     ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWSESIKD
                     MQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHELVDAITSSEQ
                     AEAVADYKHQASLKSDLVRTDLAKEKTGVWTGAYAINPVNGKEMPIWIADYVLASYGT
                     GAVMAVPAHDQRDWEFAKQFDLPIVEVLEGGNVEEAAYTEDGLHVNSDFLDGLNKEDA
                     IAKIVACLEEKGCGQEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPETELPLV
                     LPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPH
                     NTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFN
                     QGMILGTSYRDHRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDV
                     VEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITSKEILAENNGALD
                     KVYNETVKAVTEQIESLKFNTAIAQLMVFVNAANKEDKLYVDYAKGFIQLIAPFAPYL
                     AEELWQTVAETGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDISREEL
                     QEIALADEKVKAEIDGKEIVKVIAVPNKLVNIVVK"
BASE COUNT         3528 a         2774 c         2205 g         3488 t
ORIGIN      
        1 tctaacaaaa gctcaatatc ccgctcccaa ttttcataaa aagtcgatgt cttatctgaa
       61 ccaatcccat tatagtaacg atttggctcc acttggaacc agtaatccca gagattgtct
      121 cccttaccgt caccagctac acgtccttct gtctgcggtc cagaagtaga ggatccccag
      181 acaaaatcct ttggaaatct tagcataaca tttacctctt tatctactca tttctcccat
      241 tatacagaaa aaacaaggta aaaactagtt acattttttc cttgtttttc ttctgattat
      301 agtttttatt tcttgcttag gatttcaagc gtttcaagca cgttatctgc atgaacctca
      361 atggtgtcac cagttgcctt gatcttaact tctacaatgc catcggccgc ttttttacca
      421 acagtgatac ggattggaag accaatcaag tcactatcgc taaatttaac accgacacgt
      481 tcgttacggt catctgtcaa gacttcataa ccagctccca tcaagcttgc ttcaagtttt
      541 tctgtcaagg cttgcgcttc ttcatccttg acattaacag taatcaaatg cacatcaaat
      601 ggtgccaatt ctttagggaa attgattccc caagcgtaac ggtattcacc ttttggcgtt
      661 ttgttaacaa agaggcgagc gtgttgctcc atcactgctg aaagaagacg gctgacaccg
      721 ataccgtaac atcccatgat gattggcaca gcacgaccat tttcatccaa gacatctgct
      781 cccatgcttg ctgaatagcg agttccgagt ttgaaaatat gaccgatctc aataccacgc
      841 gcaaagttaa ggacaccttg tccatctggg gaaatttcac cctcacgaac ttcacggata
      901 tccacatatt ctgcagtaaa atcacggcct gggttcacac cagtcaagtg gtagccatct
      961 tcgttagcac cgacaactgc attgcgaaca tcttgcacct tacgatctgc aataatttta
     1021 atattctctg gcaaaccaac tggtccaagt gaaccaaatc ctgcttgaac aacattcgcc
     1081 acttcttctt cgctagcaac gtcaaagaaa tctgctccca agtgattttt caacttgact
     1141 tcgttgagtt ggtcatttcc aactagaagg gctgcaacaa gctcaccatc tgcaatgtag
     1201 aagagggttt taatcgtttg ttcttctgga acattgagga aagctgcaac ttcatcaatt
     1261 gatttaacat ctggcgttgc aacacgagta acttcttctt cagcgacaac acggttgctt
     1321 ggtttgtact cgtttgttgc catttctaag ttagctgcat agctagactc acttgagtaa
     1381 gcaatggtat cttcaccaga gactatccat ttgagcaatt ctgccttgat ttcttcttgc
     1441 acttctgcag gaatttcgtc aaatgaggca actgacttgt ccaagacaac ccagcggtca
     1501 aggtctgtac gagcagatgt aatggccata aattcttggc tatccttacc acccatggct
     1561 ccaccgtcac caataatagc cttgaagtct aaaccactac gagtgaaaat acgctcataa
     1621 gctgctttgt actcatcata aacactatcc aaactatcat agttagcgtg gaaactataa
     1681 gcatccttca tgataaactc acgtgtacga agaagtccat tacgcgggcg tttttcatca
     1741 cgatacttgg gctgaatttg ataaaggttg agtggcaatt gcttgtaaga tttaacagaa
     1801 tcacggacaa tagctgtaaa ggtttcttcg tgagttggac ctaagataaa gtctgatttt
     1861 tcacggtttt ttagtttgta aaggtcttca ccataggttt cgtaacgacc tgattcacgc
     1921 cacaattctg cactaagaag ggctggagcc aacatctcaa cagcaccaat cttttcgaat
     1981 tcttggcgca tgatgttttt agctttttca atcacacggt tggcaagtgg tagataagaa
     2041 taaacacctg ctgaaacttg gcgaacataa ccagcacgca acataagagc atggctgata
     2101 acttgagcat cgcttggcat ttcgcgaagc gttgggatag gcattttact ttgtttcata
     2161 atattcctcg attatctaaa aaagagtcgc ataatgtcat tccaagtcac agcaatcatc
     2221 aagacaacca tgatgaccac tccggccaag gtgacatagg tttcaatttc ttgtttcaat
     2281 ggtttgcggc ggatggcttc taggatattg agcacaatct taccaccatc caaggctgga
     2341 atcggaataa gattaaaaat cccaatattg atggaaatca ttgccaagaa gtacaagata
     2401 ttttcaattc catttttagc agcatcacta cttgccttaa agatagcaac aggtccaccc
     2461 aacttgttca aatctggttg gaaaatcaga tttttcagag ctgagagaat tcggagagct
     2521 gagtcagcag cagttgtaaa accacctaca aacatggata gaaaatctga cttacccccc
     2581 ggttgaacac ctagaaggta acgaccttga ctatctttgg gtgtaacagt gacttgtttg
     2641 tcactcccct tttcagaaat agtcacatcc aaagtcggtg ccgtcttatc tttggtttct
     2701 gtttccacag cttggatcaa gctttcccag ttgctaacct catgtgagcc aatcttggta
     2761 atttgtgccg tttctggtac tcctaccttg gccaaggcac cttggggcat gatatggaac
     2821 tgattggtat caacatctct gacaccaccc tgcataaaga ttaaaaccca aaaaacaacg
     2881 acacctaaga taaaattgtt cataggacct gcaaaattgg taatcagttt gccccagata
     2941 gtcgcatttt gatattgaac atctaaaggt gcaatccgaa cctcagtacc atctgcttcc
     3001 acaaccgttg catcgtgatc cactgcaaat gttttttctt cttccagaac caatcctttg
     3061 ataaagagct tgtcttcaaa atcaaactgg gtcacctgca tagggaggac tgtttgatcc
     3121 aattttttac ctgagagatt gatgcgttta accttaccat catcagcaag tgtcaaacta
     3181 acaggcgttc ctgtcttgat ttcagttgta tcatcacccc aaccggccat gcggacatag
     3241 ccacccagag gcaagattcg aatggtatag gccgttccat ccttgccaat gtgagcaaaa
     3301 attttaggtc ccataccgat ggcaaattca cgtactaaaa tccctgattt cttggcaaag
     3361 tagaagtgcc cgaactcgtg caccactaca ataatcccaa aaactagaat aaaggttaaa
     3421 attccaagca tagtgtttcc tccgtctttt gattaaaaga gtccaaataa gtgcatgatt
     3481 ggaaatacaa gcaacatact atcgaaacga tccaaaacac caccatgtcc agggataaat
     3541 ttcccagaat ccttaacacc aaaatgacgt ttgatcgaac tttctagtaa atcaccaaat
     3601 tgtccagcaa tgctaaagaa aatagcaaag actgacatct tgtaaattcc atatggaaga
     3661 gcaactgtac tgtcaactat cataaagata atggttacta aaattgctcc taaaatacca
     3721 cccaaggcac cctcaagggt tttattaggc gatacccttg gtgctaactt tcgtttccca
     3781 tagttcatcc caacaagata ggcaccactg tctgtcgccc agacgataca caaggctaag
     3841 agagccttgt ccaaacctgc aacacgagca tctagtaaag cattaaatcc aaagcccacg
     3901 tagaagctca tagcaagagg gaaaaccgca tcctcaatcg tataagactt gctaaaaacg
     3961 gtcgttccta acatgattga aatcaaaaca ctataggcaa ccacattccc atcaactggc
     4021 aaaaaagtca ggtaattctc caagggaatg gtcaatgcaa aggttgcaaa gagggtcaag
     4081 aggccctcca tcgtcatggt ctctagacct ctcatcttca aaagttcatg catggctagc
     4141 atggctatga ttccgattgc tatctgaagc aagaggcccc caatcattaa aattggtagg
     4201 aaaatagcca gggcaatccc tgcaaacaag gttcttttct gtaaatcctg ggtcatattt
     4261 cctcctaaac tcctccaaat cggcgatgac gacgattata ggcaagaata gcttcctgca
     4321 aggccgcttc gtcaaaatca ggccataagg tgtccgtaaa ataaagctca ctataggctc
     4381 cctgccatgg aaggaaattg ctcaaacgta attctccact agtacggata atcaagtctg
     4441 ggtctcgtaa gtccttaggc aaatgctgag taaagagata gttaccaatc aattcctctg
     4501 tgatgtcacc tgggttgatt ttggcatcta aaacatcctg ggaaatcaac ttaagcgcct
     4561 gtgtaatctc agcacgtcca ccatagttaa gagcaaaatt aagaatcaat cctgtgttgt
     4621 tcttagtcaa ttcctcagcc ttggttaaag cttcaaaggt ttgcttaggc aggcggtctg
     4681 tctccccaat catttgaatc ttaacattat tcgcatgtag ttccgggaca taattatcat
     4741 aaaactctac tggcaagttc atgataaact tgacttcctg atctggacgg gtccagtttt
     4801 ccgtagaaaa agcatagacc gtaataacct tgacgcccag tttgttggct gccttggtca
     4861 cggtttgcaa tgcttccatg cccgccttat gtccaaaaac tcgcggttgc atacgttttt
     4921 tagcccaacg gccattgcca tccatgatga tgccgatatg agcaggaacc tgtgtcggaa
     4981 cctctacttc cacagcctta tctttcttaa aaaatccaaa catgatctta ttcctattca
     5041 aaaatctatc gtttcattat accatatttc cccattttct tctatcacta agctatttat
     5101 tctcaggcac catgcccatt tttcaaaaaa ataagccgcc tgattgggcg actttatttt
     5161 tatagggaga ttattatgaa aaagttttag gagtttaagt taaggtcttc ttaacttatg
     5221 aacttagtgt acactcccta gcttaaagtt tccttaagta tttttaaaaa tcaaattttt
     5281 ccatttctcc tgccaatttt tcttggataa acgtgtttga tagagttcca ttcggtcttc
     5341 attttctaag aaatgaggag ttggacgaac ttgaaaattc aaaatatcct ccaaaccata
     5401 aggtgcatag agttcaaaat ctgattcttc attcaagcgc agtccaactg ccgtacaccg
     5461 ttctggatac ttactcatag catcacgaga actggtatag gaagcagtgt gaggactgtg
     5521 ctggtgcata tagacctgat ttttcaattc ccactggtac tgaggaaaat cctctctcag
     5581 ctttttctcc agtaataagg tttcctcata agaaaaatct ggatcaaaga aaatcacatc
     5641 tatatctgtt tcatgatcaa aaggggattt gtctgacaaa agattccaga tgaaatttct
     5701 gacagaacct gctgccaact acgagtcttt caaaccaagg tctcggatga tcgtcagaat
     5761 ggccatcata tctggatttt ctctaaaagc ctctaagatt tcttgcttat ttttcactgt
     5821 attcataacc taagtgctca tatgccttag cagtcgccac ccgtccagac cgtgtccgca
     5881 tgataaaacc tttttgaatc aagtaaggct catacatgtc ttcaactgtc tcacgctctt
     5941 cggcgatatt gacagaaaga gttcctagac caacaggtcc tccactgtac atctcaatca
     6001 tggtacgaag gattttttga tccacatagt ccaaaccttc atggtcaaca tccagcatag
     6061 tcaaagcctt atcggtaata atatcatcga ttaccccatt ccccattatc tgggcaaaat
     6121 cgcgcacgcg cttgaggaga cgattggcaa tacgaggggt tccacgacta cgtagggcca
     6181 actcagatgc tgcctcatga gtgatttcca tctcaaaaat atctgccgtc cgctcgacaa
     6241 tttctgtcaa gtcagcatgg gcataatact ccatatgacc tgtaatccca aaacgtgccc
     6301 gtagtggatt tgagagcata ccagcccgag tcgtcgcacc aatcaaggta aaaggaggca
     6361 actccaaatg aacactgcga ctgccttcac cagccccaat cataatatcg atgtagaagt
     6421 cctccatggc actataaagc acttcttcca ctgacatggg taagcgatga atctcgtcaa
     6481 taaagaggac atctccaggc tctaactcat tcaaaatcgc taccaaatca cccgcttttt
     6541 cgataacagg accagacgtt tgcttgagat tgactcccag ttcattggca atgacaaaag
     6601 ccatggttgt tttcccaagc cctggagggc caaataagag cacatgatcc agcgcttcat
     6661 cccgcatttt agcggcttcg ataaagatct gaagctgatc cttaacctta tcctgaccaa
     6721 tatattcacg taaatactga ggacggagcg tgcgttctac taactcctca tcacccatca
     6781 tctcattatc taaaattcta ctcatggctc tattatatca aaaaaacaag ccacaaacaa
     6841 aaaagccacc tgattgggtg actcctaagt ttagcactta tgtggtataa tattatacgg
     6901 cacttctaca ccgcctacga aaggaggtga gatagcccat gatggaatta gtactcaaaa
     6961 ctatcatcgg accaattgtg gtcggtgtcg ttcttcgtat agtcgataaa tggctaaaca
     7021 aggacaaata gtgtcaaaaa agacctcaag cttatttggt cgtgagcttg gggtcttttc
     7081 tagcctatga tatagaacta gtactcaatt cctttttatt atcccatagt tcacgaattt
     7141 tgtcaaaggt ttacattttc ttcaaccgct gtacgacaag acggttaaga ttaagagaac
     7201 gttagggatt ctatcaattt catagaaatt ttgatttcgt aaacgaagag acaatcttac
     7261 atgtcacttc tcatttaata cgccactact agacaagcaa aatcattatt acagtagttc
     7321 cagttcttca attaacagtc acttacaatc aaattgagtt tgaactagct gaagcgacca
     7381 cagacctatt tcttagttat attcgctaaa aaagtccccg ccaattcccc gaccaaaatc
     7441 cgaaaaatac cgaaaaatat cgaaaaatta tttttagaat agtccccaaa agcctgaaat
     7501 agagctaaaa aactccacct gattgggtgg agttaaggga gattattatg aaaaagaaaa
     7561 gtttaggatt ttattaaata aagttaggag gtctttattt aataactaca tgatacaaga
     7621 cgaaacttaa aactagctta acttttctaa aattttacta ttttgcaaaa aatttctatc
     7681 accagcacct caccacgcaa aaaagccacc tgattgggtg gcttcattag gagattgtga
     7741 tgaaaaaagt ttaggatttt attaaataaa gttaggaggt ctttatttaa tgattatata
     7801 atactagacc atccttaaat tttgcttaag aaaaaacaag ttttgttatt ttttacgatt
     7861 catccaagtc atccctatcc aattataggt ggataagatt tcaaagccca tagaacgatt
     7921 aaatcccacg tttttttctg tctgttctgt cgccagctgg acttgatagg cctctttaaa
     7981 atttcctaaa gcctgtttca tcaaggagct accaatccct tggcgctgat agctagacaa
     8041 aacaatcaaa tcctgtacaa aaactgatga aaaaccatct ccaaccaaac gaatcaagcc
     8101 cacaacagca tcaccatcaa gtgccagata aattattaat gaatgataca aggtctactc
     8161 cagcatctga ggttgatttg tataatttgt ccaaccgaca gcctgataga gatgcaaaac
     8221 atcctcgaac ttgacgattt cttgctttct aatagtgatc atgtcaacac ctcttaaaac
     8281 tctctcaagc tcttgtactg ctgtccattt ttatcaaaat tttcaggacg caaccatgtt
     8341 tccaaacgat ctttgacttt gggccagtcc ttatcaatca tagacaacca atccatatct
     8401 ctcgtacgcc ccttataaac cactgcctga cggaaggttc cttcataaat aaagcccaaa
     8461 cgctccgcag cacgtctgga tggcaggtta agagcatcgc atttccactc ataacgacga
     8521 tagttaagct cttcaaagac atagcgagcc agtagatact gggcttctgt ccctatccgt
     8581 gtccccctga gttttggaga aaaagtgaca gctcccactt ctattactcc gttactggtc
     8641 aatacgcatg agagaaaaag ttcccaaagc cttaccagtt gccttgtcta tgattgcata
     8701 gtaaaaacgg tccttacgac caacatctga tttaaaaggc tgaccagttc ctcaatgtct
     8761 gctactggct cctgaaagag gtaggtccac atctcctgag gagtatcagg accataaaca
     8821 gctagcaaat cctccgcatg cttttccact gaaagagcct ctatcctagc ataacgccct
     8881 tctaagagat caataaaagt cagttcacct ggtgtataac cttccattga ctcaccaatc
     8941 atctgaccat attcgtttac tggtataact ttctccttgt ttcgcttttc aaactttata
     9001 gttgcccata gtatagcgta ttgaaataag atgagaacaa atcgattggg aaagtaaaat
     9061 taatttctat aaatgtttta gcaattgttt cgtactattt tagattcagt ctactatata
     9121 tcatactttc ataagaaggt tcaaaaaatc ctccagattc tactctgaag gattcctatc
     9181 ttatttcaca acaatgttaa ctaatttagt tggcttcaat agtccagtgg actattgaag
     9241 gtggcagata gagctaataa actcgttatt taacgacgat attaacgagt ttattcggta
     9301 ccgcaattac tttcacgatt tccttaccgt caatttctgc tttgactttt tcatcagcta
     9361 aagcgatttc ttgtaattct tcacgtgata tatctttagc aaccatgagt ttggcacgga
     9421 cttttccttt gatttggaca acaatttcaa tttcatcttc aaccaatttg ctttcgtccc
     9481 aagttggcca agctacataa gagattgact cacctgtttc tgcgactgtt tgccagagtt
     9541 cttctgccaa gtaaggtgca aatggtgcaa tcaattgaat aaagcctttg gcatagtcaa
     9601 cataaagctt atcttccttg ttagcagcat tgacaaagac cataagttgg gcaatagctg
     9661 tgttgaattt gagagactca atttgctcag taacagcttt gactgtttcg ttgtaaacct
     9721 tgtcaagagc accattgttt tccgcaagga tttctttact tgtaatcaaa cggtaaactc
     9781 ggtcaaggaa cttacggctt ccttccaaac cttcttctga ccaagcaatc gaagcatcga
     9841 gtggtcccat aaacatttca taaacacgaa gggtatcggc accgtattgt tccaccacat
     9901 cgtctgggtt aacaacgttc ttgagcgatt tagacatctt ggctggcgct tgctccaact
     9961 cttcccctgt ttctacatga aagaaggaac catcacgttt ttcaaccttg tcggttgcca
    10021 caagagcacc acggtggtca cggtagcttg ttcccaaaat catcccttgg ttaaagagtt
    10081 tttggaatgg ttccttagtc ggaacaacac cgaggtcata gaggaattta tgccagaaac
    10141 gagcataaag caagtgaagt acagcatgtt ccgcaccacc cacgtagata tctactggca
    10201 accattgttt gaggaggtcc tcatcagcca atttctcagt attgtgcggg tcaatatagc
    10261 ggaggtagta ccagcttgaa ccagcccatt gtggcatggt gttagtttca cgacgacctt
    10321 tgacaccatc ttcacgagtc acttcaagcc aatctgtcaa gttagctagt ggactttcac
    10381 cagtacctga aggacggata tccttggtta caggcaagac aagcggcaat tcagtttcag
    10441 gaacagctgt tgaagttcca tcttcccaat gaatgattgg aattggctca ccccagtaac
    10501 gttgacggct aaagagccag tcgcggaggc ggtaggtaac cttctcctga ccacagcctt
    10561 tttcttccaa gcaagccaca atcttggcaa tagcgtcttc tttattcaat ccatctagga
    10621 agtctgaatt gacatgcagg ccatcctctg tgtaggcagc ttcttcgaca tttccacctt
    10681 caagtacttc gacgattgga aggtcaaatt gtttggcaaa ttcccagtca cgttggtcgt
    10741 gggcaggcac agccataacc gcacctgttc cataactagc aagaacatag tccgcaatcc
    10801 agattggcat ttccttacca ttgacagggt tgatggcata ggcacctgtc caaacaccag
    10861 ttttttcctt agcaaggtct gtacgaacca agtcagactt aaggctggct tggtgtttat
    10921 agtctgctac agcttctgct tgctctgaac ttgtgatagc gtctactaat tcatgttcag
    10981 gagccaagac agtgaaagtc gcaccgaaaa gtgtgtccgg acgagtagta aagactgtaa
    11041 attccttgtc tgttcctttt actttgaaag ttacattggc accagttgat ttaccaatcc
    11101 agttgcgttg catatccttg atagactctg accaatctag ttcatctaag tcattgagca
    11161 agcgctctgc gtaagccgtg attttgagca tccattggcg cattggtttg cggacaactg
    11221 gatagcctcc acgctcagaa gttccgtcag gaagcacttc ttcattggca atggcagttc
    11281 ccaattcctc aacccagttt actggcactt cagcttcata ggccaagcct ttttcgtaaa
    11341 gcttggtgaa aatccattga gtccacttgt agtagtttgg atctgttgtg ttgacttcac
    11401 gatcccagtc ataagaaaat ccaagcgcat tgatttgacg tttgaagttg gcaatgtttt
    11461 ccgctgtaaa ttctgctggg tcattaccag tatccatagc gtattgctct gcaggcaaac
    11521 caaaagcatc ccaacccatt gggtgaagga cattgtagcc ttgcgcacgt ttgtaacgac
    11581 tgaggatatc ggttgcagta taaccttctg ggtgtcctac gtgcagacca actccagacg
    11641 gataagggaa catatcaagc gcataaaact taggttttga tgtatctgtt cctgtcttaa
    11701 atgtatgatg ttctgcccag tagccctgcc acttaggctc aatttcttta tgattataaa
    11761 aactcatggt ctctctccaa ttttgtgatg ttactattat accatttttg agggaatttg
    11821 aaatgtgttt aaagaaaaaa ctgtatactg tatctcatta attttgatga ctatgaattg
    11881 ctctatctcc cactttttat cccattgtta tgcagtaaat caaggagtaa gtcaagacgc
    11941 ttatctcgta tagcacaaaa tacttatttt agaccgaaga taaaactgga atgct
//
LOCUS       DBMVGT010000052        11932 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.052, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000052 DBMVGT010000000
VERSION     DBMVGT010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 11932)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11932)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11932
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.052"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..812
                     /locus_tag="AC0DU4_001560"
     CDS             <1..812
                     /locus_tag="AC0DU4_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000950172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008184 - glycogen phosphorylase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan phosphorylase"
                     /protein_id="HIN4237498.1"
                     /translation="NSIFDIQIKRLHEYKRQQMNALYVIHKYLDIKAGNIPARPITIF
                     FGGKAAPAYTIAQDIIHLILCMSEVIANDPAVAPHLQVVMVENYNVTAASFLIPACDI
                     SEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAELVGEENIYIFGEDSETVID
                     LYAKAAYKSSEFYAREAIKPLVDFIVSDAVLAAGNKERLERLYNELINKDWFMTLLDL
                     EDYIKVKEQMLADYEDRDAWLDKVIVNISKAGFFSSDRTIAQYNEDIWHLN"
     gene            complement(1857..2429)
                     /locus_tag="AC0DU4_001561"
     CDS             complement(1857..2429)
                     /locus_tag="AC0DU4_001561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237499.1"
                     /translation="MNKLMKFISVFLTSIVLIVSAIPSVSAVYASEQVSQIETNMELQ
                     PVTSLTEEQINTLANEIQSFHPDVSQQWIKEVINRQLQGDYTIPPTYSPFRAAWQGIT
                     VNQMGALLDTAIALALGGTTAGLANLIKVKGKHAAKSAIRSAISRYLGSWFVNDVALE
                     SAMNLLSPGTYLTQLWDKNDAIPNNGRINF"
     gene            2507..2713
                     /locus_tag="AC0DU4_001562"
     CDS             2507..2713
                     /locus_tag="AC0DU4_001562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237500.1"
                     /translation="MLKKYFSKYKWTDLFWILFVIGACLLTGNSSLFPLTHQEFSFRG
                     SVWGLVLALYHLLFIDKFVISNRK"
     gene            complement(3054..3902)
                     /locus_tag="AC0DU4_001563"
     CDS             complement(3054..3902)
                     /locus_tag="AC0DU4_001563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative RNA methyltransferase"
                     /protein_id="HIN4237501.1"
                     /translation="MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNRHSFDL
                     AKFGYVNLAPQIKQSANYDKENFQNRQQILEAGFYQAILDAVSDLLASSKTTTTILDI
                     GCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDLARLPIKDAN
                     MDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIK
                     EHFQEHFTILSSQTASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSQLTEITIEAEI
                     LVGKAF"
     gene            4054..4332
                     /locus_tag="AC0DU4_001564"
     CDS             4054..4332
                     /locus_tag="AC0DU4_001564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003075836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6110 family protein"
                     /protein_id="HIN4237502.1"
                     /translation="MLKEVLTVAKVAKKSSLFLGGVAFGTLGLKILASKEAKKGYSKA
                     LAKAYKLKDELDASVSVVKQHGDDVLQDAKYLYEQEKKEEQLDSLIGE"
     gene            4334..6397
                     /locus_tag="AC0DU4_001565"
     CDS             4334..6397
                     /locus_tag="AC0DU4_001565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000008803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HIN4237503.1"
                     /translation="MSFKVLHRGYQHIRLSSSFSLTLDIQDYLRSLARDEKGIESIQF
                     YMDQQHFTLRIKEGFSVLDNAEAFLKRIDKGKVSELMTLPIRREESAYSIVSGAAVKR
                     VLFRSFVPYPIRYIWTCYQALGYIREAYQTLARKELTMEVLDCSAILLSLFMNQSKTA
                     SNIMFMLDLGNHLDQWSLKKTATDLEQSLLAKESDVFLVQGDTVVSIKSSDVQIGDVL
                     ILSQGNEILFDGQVVSGLGMVNESSLTGESFPVEKRESDLVCANTVLETGELRIRVTD
                     NQMNSRILQLIELMKKSEENKKTKQRYFIKMADKVVKYNFLGAGLTYLLTGSFSKAIS
                     FLLVDFSCALKISTPVAYLTVIKEGLNREMVIKDGDVLEKYLEVDTFLFDKTGTITTS
                     YPIVEKVLPFGDYSEEDILRISACLEEHIYHPIANAIVKQAEIEGIEHEEMHGKLQYI
                     ASKGIKSHIDGQPVLIGNYVLMQDEQIHISSEQNALIEEYKSHYNLLFLAYQNELIGM
                     FCIHTPLRKEAKTALDKLKAQGKKLILATGDTLIRTEELVKDLPFDQVYTDLKPDGKF
                     ELVEKLQKAGHTILMVGDGLNDSAALTLSDIGVVMNESADISKQMSDILLLDNRLDFF
                     QELDSLSSSLQTLIKKNIQDTVVVNSSLIGFGLFNWFSPSNLSILHNLTTLRIVLRSL
                     SIKNR"
     gene            complement(6475..7731)
                     /gene="tyrS"
                     /locus_tag="AC0DU4_001566"
     CDS             complement(6475..7731)
                     /gene="tyrS"
                     /locus_tag="AC0DU4_001566"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004831 - tyrosine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HIN4237504.1"
                     /translation="MHIFDELKERGLIFQTTDEEALRKALEEGQVSYYTGYDPTADSL
                     HLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVKSIQ
                     GQLSRFLDFENGENKAVMVNNYDWFGSISFIDFLRDIGKYFTVNYMMSKESVKKRIET
                     GISYTEFAYQIMQGYDFFVLNQDHNVTLQIGGSDQWGNMTAGTELLRRKADKTGHVIT
                     VPLITDATGKKFGKSEGNAVWLNPEKTSPYEMYQFWMNVMDADAVRFLKIFTFLSLDE
                     IEDIRKQFEAAPHERLAQKVLAREVVTLVHGEEAYKEALNITEQLFAGNIKNLSVKEL
                     KQGLRGVPNYQVQADENNNIVELLVSSGIVNSKRQAREDVQNGAIYVNGDRIQDLDYV
                     LSDADKLENELTVIRRGKKKYFVLTY"
     gene            7873..10338
                     /gene="pbp1b"
                     /locus_tag="AC0DU4_001567"
     CDS             7873..10338
                     /gene="pbp1b"
                     /locus_tag="AC0DU4_001567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein PBP1B"
                     /protein_id="HIN4237505.1"
                     /translation="MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKS
                     AIFPAILLSIKALFNLLFVLCFLGGMLGVGIALGYGVALFDKVRVPQTEELVNQVKDI
                     SSISEITYSDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAV
                     IRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEI
                     LTTYLNVAPFGRNNKGQNIAGARQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPY
                     ENTGELKSDEDLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGI
                     SRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEATQKFYRDLAAKEIENGGYKITT
                     TIDQKIHSAMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNH
                     AFDTKRSPASTTKPLLAYGIAIDQGLMGSETILSNYPTNFANGNPIMYANSKGTGMMT
                     LGEALNYSWNIPAYWTYRMLREKGVDVKGYMEKMGYEIPEYGIESLPMGGGIEVTVAQ
                     HTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVL
                     SSRVTTTFKSNLTSLNPTLATADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNH
                     SLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALDPSVVKSEVLKSTGQKPGKVS
                     VEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSS
                     SSSSSSDSSNSSTTRPSSSRARR"
     gene            10403..11314
                     /locus_tag="AC0DU4_001568"
     CDS             10403..11314
                     /locus_tag="AC0DU4_001568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HIN4237506.1"
                     /translation="MNQYQKKIVNGKIYSLLSGLIWGICGILGEYFFTHYQVSSGWIT
                     SMRLTLAGSLVLIWSAIQLKSQVLDIWRDKKNYLPFLAYAILGIFSVQYFFYLCVEYS
                     NATTATILQFISPVFILFYNRLVYQKRASKSAVFYVLVAMLGVCLMATKGDLSQLSMT
                     PLALITGLLSAMGVMFNVILPQPFAKRYGFVPTVGWGMILAGLFSNVLSPVYQLSFTL
                     DIWSILICLIIAFFGTAFAFFISMKAVSLVSPLVVAVISASEPLSSALLSVLFLGLVV
                     DWSLLLAIALIILPMIFLSIEEAKESR"
     gene            11544..>11932
                     /locus_tag="AC0DU4_001569"
     CDS             11544..>11932
                     /locus_tag="AC0DU4_001569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-acetyltransferase"
                     /protein_id="HIN4237507.1"
                     /translation="MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLG
                     NVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVEI
                     GDNAVIMMGAVINIGAEIGAGTMIDMGA"
BASE COUNT         3474 a         2114 c         2554 g         3790 t
ORIGIN      
        1 caaattctat ctttgatatc caaatcaaac gtcttcacga gtacaaacgc caacaaatga
       61 acgctttgta cgtaatccac aaataccttg acatcaaagc tggtaacatc cctgctcgcc
      121 caattacaat cttctttggt ggtaaagcag ctccagccta cacaatcgct caagatatca
      181 ttcacttgat cctttgcatg tcagaagtta ttgctaacga tccagcagta gctccacact
      241 tgcaagtagt tatggttgaa aactacaacg ttactgcagc aagcttcctt atcccagcat
      301 gtgatatctc agaacaaatc tcacttgctt ctaaagaagc ttcaggtact ggtaacatga
      361 aattcatgtt gaacggagct ttgacacttg gtactatgga cggtgctaac gtggaaatcg
      421 ctgagttggt tggagaagaa aacatctaca tcttcggtga agattcagaa actgttatcg
      481 acctttacgc aaaagcagct tacaaatcaa gcgaattcta cgctcgtgaa gctatcaaac
      541 cattggttga cttcatcgtt agtgatgcag ttcttgcagc tggaaacaaa gagcgcttgg
      601 aacgtcttta caatgaattg atcaacaaag actggttcat gactcttctt gacttggaag
      661 actacatcaa agtcaaagag caaatgcttg ctgactacga agaccgtgac gcatggttgg
      721 ataaagtcat cgttaacatt tctaaagcag gattcttctc atctgaccgt acaatcgctc
      781 agtataatga agacatctgg cacttgaact aatactcttc gaaaatctct tcaaaccacg
      841 tcagctttat ctgcaacctc aaagcggtgc tttgagcaac ctgcggctag cttcctagtt
      901 tgctctttga ttttcattga gtataagatg caaatttata ctaatacatt ttgtaaaaaa
      961 gcgagtttcg attgaaattc gcttttttaa atgctgtgga tttgggtcaa tcttgtctaa
     1021 aaatagggaa atcctagata cagtgaaggc tttaaatgct ggtttttact gtcttcagcc
     1081 ttatattttt tcgtagttgg ttacctcata tctcttgtat tcgcttacat aaagtattat
     1141 aatataattg taggaaagaa ggtgttttta tgatatacac acttaaattg gtgttgttta
     1201 ttacctttct tgtaataagc ttgttacctg ataagatttt tggaaaaaat aaaaaaattt
     1261 ggaaaatagt ttttgcaata ttgacggcag tggcagcatt tatatttatg tactaagtta
     1321 ttttaagaat gtagggaaat aaaccctaca ttctttttag ttttttctgt tttctaaatt
     1381 ctatttatcc aagcgcttca acatttcttg cttcttcgct tcaagttctg cacgcttttc
     1441 ttcgatttcg gcatgttttt tctcgagttc agaacaactt gcaccattgc taaattcttt
     1501 tcgccatcag gagatagggt gagtcgacat gtctattact cacccaaagc agtcctacaa
     1561 agcaggaatt ttctgttact tttttggaaa tagtaacgtt tatacagctt tgacacttcg
     1621 tatcaaagcg ccaaacacac tccgagggat ttacagaaag cagaaaagga atgatctggt
     1681 ataagatcat tccttttctc tctttttctt taagtaatta tatacaatgt acgacgaagt
     1741 cgtcattgca atgctgatcc accacctaaa gggaacttta aacaacattg ataagataaa
     1801 gaatataaac aacgaaaata cgttataccc aattaatttt attgtatatc tcatgattaa
     1861 aagttaatcc ttccgttgtt aggaatggca tcatttttat cccataattg tgttaaataa
     1921 gtccccggtg ataataaatt catagcggat tctaaagcaa catcatttac aaaccaacta
     1981 cctagatatc tagaaattgc tgaacgaata gcactttttg ctgcatgttt tccttttact
     2041 ttaattagat ttgcaaggcc tgcagtagtt cctcctaatg ctaaagctat tgcagtatct
     2101 aatagagcac ccatttgatt aactgtaata ccttgccaag ctgctctaaa tggagagtat
     2161 gtaggtggga ttgtataatc gccttgtaat tgtcggttaa ttacttcttt gatccattgt
     2221 tgtgagacgt ctggatgaaa agattggatt tcgtttgcaa gtgtattgat ttgttcttct
     2281 gttagagaag tgacaggttg aagttccata tttgtttcaa tttgtgatac ttgttcagaa
     2341 gcgtatacag ctgaaacact tggaatcgct gatacaatta acacaattga cgtcaaaaaa
     2401 accgaaataa atttcattaa tttgttcatg agcttttctc ctttttattt gtatttgctt
     2461 acattttatt atatactgtt attatagtca agaaaaatat gctattatgt taaaaaaata
     2521 tttttcaaaa tataaatgga cggatttatt ttggattctt tttgtaattg gggcatgcct
     2581 cttgacgggt aatagtagtc ttttccccct tacccatcaa gaattctctt ttcgtggtag
     2641 cgtttggggt ctggtactgg ccttatatca cttattgttc attgataagt ttgtaatttc
     2701 gaatcgaaaa taaaaattag aactatgatt gactggctac ttttaatatt gattttggag
     2761 gaagattttg tctctattat ttattatttt aaatttatct attttgtaca agatttattc
     2821 tttgagacgg gagaagtcga aatacttgat ttatacggcc tatatcatat ttggggtaaa
     2881 tgtagtatat ggtattcaat ggttattaaa agaactgatt tcaactattt ccacttaata
     2941 tgtatgaaaa ctataacaaa acgcataaga ttaaggtttt taagcacctg ttcttatacg
     3001 tttttgtaat attgaagatt ttcggtaagt tttctacttt tgcgaagtct agtttagaat
     3061 gctttcccaa ccaaaatctc tgcttcgatg gtaatctctg tcagttggct ccagtcaatc
     3121 ttgctctggt caacgtgaaa gaggagagga gtcatactga gtagggcttg gagttgttct
     3181 gctgtgatag tcttagtcag agaggcagtt tgactagata ggatggtaaa gtgttcctgg
     3241 aaatgctcct tgatatcttg gttagaatac tccttgtttg tcagctggtc ctgtactctt
     3301 tgacggattt ctttgaggtg attttcagtt gggataacct ttatcaagat accgtctttg
     3361 gataaaacgc gacgaaattc tccatagttg gcaggtgaga agatatcaag cagaatatcc
     3421 atgttagcgt cttttatagg aagtcgtgcc aagtcgccaa cgaaccaatt gactgcccag
     3481 ttgggttcac ttttagcagc gatttggact gaatctttgg agatgtcaaa ggcatagaaa
     3541 gttttttcag agtgactttc ttgtagtttg cgagaataga atccttcacc acaaccgata
     3601 tccaaaattg ttgtggtagt ttttgagctt gcaagcaagt cagatacagc atctaagata
     3661 gcttggtaaa agccggcttc taggatttgt tgacggtttt gaaaattttc cttgtcatag
     3721 ttagcagatt gcttgatttg aggtgctaga ttgacatagc caaatttcgc caagtcaaaa
     3781 gaatgacggt tgcagcactt gaaattagtc tctaacagag tcagattttc ttgacagata
     3841 ggacaggcaa aggcagtcgc agaagcaaaa cgctgaagtt tgggcttgag atttgtattc
     3901 atagtttaag tgtatcaaaa gaggcaaatg aaagcaactt taggaataag tagatgggag
     3961 attcagtaga aataaaacta attctccaat ttatagaatg aaattgcttt tatatctaaa
     4021 ttgctatata ataatgataa ggaggaaata agtatgttaa aagaagtatt aaccgttgca
     4081 aaagttgcga aaaaatcttc attatttttg ggtggtgtcg catttggtac ccttggtttg
     4141 aaaatcttag caagtaagga agctaaaaaa ggttattcta aagctttggc taaggcttac
     4201 aagttgaaag acgagctaga tgcatctgtt tctgttgtga agcaacatgg agacgatgtc
     4261 ttgcaagatg ccaaatattt gtacgagcaa gagaaaaaag aagagcaatt agatagcctt
     4321 ataggtgaat aatatgtctt ttaaagtgct acatagagga taccaacata tccgactatc
     4381 atcttctttt tcacttacct tggatattca agactatctt cgttccttgg cgagagatga
     4441 aaaggggatt gagtctatcc agttttacat ggatcaacag cactttactc tacgcataaa
     4501 agaaggcttt tctgtattag ataatgcaga agccttttta aaaagaattg ataaagggaa
     4561 agtttctgag ttgatgactc ttcccattcg tagagaagag agtgcttatt ctattgtttc
     4621 aggtgcagcg gttaagcgtg tactttttcg tagttttgtg ccgtatccta ttcgctatat
     4681 atggacttgt tatcaggctt tgggttatat tagagaagcc tatcaaacac tagcgcgtaa
     4741 ggaactaacg atggaagtct tggactgttc ggctatttta ttgtccttgt ttatgaacca
     4801 atccaagaca gctagcaata tcatgtttat gcttgatttg gggaatcatt tagatcagtg
     4861 gtccttgaaa aaaactgcaa cagatttaga acagagtctt cttgcaaaag agagcgatgt
     4921 attcctagta cagggcgata cggttgttag tataaagagt tccgatgttc aaataggaga
     4981 tgtcttgatc ttatctcaag gaaatgaaat tctgtttgat gggcaagtag tttcaggttt
     5041 aggtatggtc aacgaaagtt ccttgacagg agagagtttt ccagttgaaa aaagagagtc
     5101 tgatttggtt tgtgcaaata cagtattaga aactggagag ttacgcattc gtgtaacaga
     5161 taatcagatg aacagccgta ttttacagct gattgagttg atgaagaaat ctgaagaaaa
     5221 caagaaaacg aaacaacgct atttcatcaa gatggcggat aaagtcgtca aatataattt
     5281 cttgggggct gggctgactt acctattgac aggttctttt tctaaggcta tttctttcct
     5341 attggtcgat ttctcctgcg ctttgaaaat ctctactcct gtagcttatt tgacagttat
     5401 caaggagggg ttgaaccgtg aaatggtgat taaggatgga gatgttctgg agaaatatct
     5461 ggaagttgat actttcttgt ttgataagac aggaacaatc acaactagtt atcctatagt
     5521 tgaaaaggtg ttaccttttg gagactatag tgaggaagat attctcagaa tcagtgcctg
     5581 tcttgaggaa cacatttatc atcctattgc taatgccatc gtcaagcaag ctgagataga
     5641 gggaattgaa catgaggaaa tgcatgggaa actccaatat atcgcaagca aggggatcaa
     5701 atctcatata gatggccaac cagttcttat tgggaattat gtcttgatgc aggatgagca
     5761 gattcatatc agttcagagc aaaatgcttt aattgaagag tacaagagtc actacaatct
     5821 cttattcttg gcttatcaaa atgaattgat tggaatgttc tgcattcata ctcctttgag
     5881 aaaagaagca aaaacagcct tggataaact taaggcacag gggaaaaaat tgattctggc
     5941 aacaggagac accttgatta ggacagagga attagtcaaa gatttgccct ttgatcaggt
     6001 ctatacagac ttgaaacctg atgggaaatt tgagttagta gagaaactgc agaaagcagg
     6061 tcacactatt ttgatggttg gagatggctt gaatgactca gcggctttaa ctctatcaga
     6121 tatcggtgtg gtgatgaatg agagtgcaga tatttctaag cagatgagtg atatcttatt
     6181 gttagataat cgtttggatt tcttccaaga gttggattcg ttatcatcat ctttgcaaac
     6241 actcatcaag aaaaatattc aggataccgt tgtcgtaaat agtagtttga ttggctttgg
     6301 cttatttaat tggttcagtc cttcaaatct ctctatctta cataatctaa caaccttgcg
     6361 cattgtcctg cgtagcctgt ctattaaaaa tagatagatg agagttatta acagcaaaaa
     6421 ggagttacct ttctcgaggt taactccttt gtttatagat aaatgttgaa tagtttagta
     6481 agtcaataca aagtattttt tcttcccacg acggataaca gtcagttcat tttctaactt
     6541 atcagcgtca ctcaagacat agtcaaggtc ttggatgcgg tcgccgttta cgtagatggc
     6601 tccgttttgg acgtcttcac gggcttggcg ttttgagtta actataccag atgagacgag
     6661 cagttccacg atattgttgt tttcgtctgc ctgtacttgg tagtttggca caccacgaag
     6721 tccttgtttg agctctttga cagaaaggtt tttgatgttt cctgcaaaga gttgctcagt
     6781 gatgttaagt gcttctttgt aggcttcttc tccgtgaaca agtgtaacaa cttcacgagc
     6841 caagactttt tgagccaagc gttcgtgtgg cgctgcttca aattgtttac gaatatcttc
     6901 aatctcatca agtgacaaga aagtaaagat tttcaagaag cgaacagcgt cagcgtccat
     6961 cacgttcatc cagaattggt acatttcgta tggagaagtc ttttcgggat tgagccagac
     7021 ggcatttcct tctgatttac caaatttctt accagttgca tctgtgatta gtggaacagt
     7081 gataacgtga ccagtcttgt ccgccttacg acgaagcaat tcggtaccag ctgtcatatt
     7141 tccccactgg tcagaaccac cgatttgaag agtgacatta tggtcttggt taaggacgaa
     7201 gaagtcgtac ccttgcatga tttggtaagc gaactcagtg taagaaattc ctgtttcgat
     7261 ccgtttttta acagattcct tactcatcat gtagttgacc gtgaagtatt ttccaatatc
     7321 acggaggaag tcaatgaagc tgatgctgcc aaaccagtcg tagttgttga ccatgacagc
     7381 cttgttttcg ccattttcaa agtcaagaaa acgagaaagt tgtccttgga tagacttgac
     7441 ccagccatct actgtgtctt ttgtttggag actacgttca gcatctttga aggacggatc
     7501 tccgatgaga cctgtagcac cgccaacgag cgcataaggt ttgtgacctg ctagttgcaa
     7561 gcgacgactt gtcaagattg cgacaaggtg gcctaggtga aggctgtcag cagttggatc
     7621 gtagccagta tagtaagaaa cttgaccttc ttctagggct ttacgcaaag cttcttcatc
     7681 agtcgtttga aatatcaaac cacgctcttt tagctcatca aaaatgtgca tgtgtctttt
     7741 ctccttttta aaattattgt ttctacctat tgtatcacaa acttgggcaa tagcctagca
     7801 gaatagggaa gaaagtggct attttattga aaatttccct tttgtggtat aatagataaa
     7861 gtgaggaaat ccatgcaaaa tcaattaaat gaattaaaac gaaaaatgct ggaatttttc
     7921 cagcaaaaac aaaaaaataa aaaatcagct agacctggca agaaaggttc aagtaccaaa
     7981 aaatctaaaa ccttagataa gtcagccatt ttcccagcta ttttactgag tataaaagcc
     8041 ttatttaact tactctttgt actctgtttt ctaggaggaa tgttgggagt tgggattgct
     8101 ttggggtacg gagtggcctt atttgacaag gttcgggtgc ctcagacaga agaattggtg
     8161 aatcaggtca aggacatctc ttctatttca gagattacct attcggacgg gacggtgatt
     8221 gcttccatag agagtgattt gttgcgcact tctatctcat ctgagcaaat ttcggaaaat
     8281 ctgaagaagg ctatcattgc gacagaagat gaacacttta aagaacataa gggtgtagta
     8341 cccaaggcgg tgattcgtgc gaccttgggg aaatttgtag gtttgggttc ctctagtggg
     8401 ggttcaacct tgacccagca actaattaaa cagcaggtgg ttggggatgc gccgaccttg
     8461 gctcgtaagg cggcagagat tgtggatgct cttgccttgg aacgcgccat gaataaagat
     8521 gagattttaa cgacctatct caatgtggct ccctttggcc gaaataataa gggacagaat
     8581 attgcagggg ctcggcaagc agctgaggga attttcggtg tagatgccag tcagttgact
     8641 gttcctcaag cagcattttt agcaggactt ccacagagtc ccattactta ctctccttat
     8701 gaaaatactg gggagttgaa gagtgatgaa gacctagaaa ttggcttaag acgggctaag
     8761 gcagttcttt acagtatgta tcgtacaggt gcattaagca aagacgagta ttctcagtac
     8821 aaggattatg accttaaaca ggacttttta ccatcgggca cggttacagg aatttcacga
     8881 gactatttat actttacaac tttggcagaa gctcaagaac gtatgtatga ctatctagct
     8941 cagagagaca atgtctccgc taaggagttg aaaaatgagg caactcagaa gttttatcga
     9001 gatttggcag ccaaggaaat tgaaaatggt ggttataaga ttactactac catagatcag
     9061 aaaattcatt ctgccatgca aagtgcggtt gctgattatg gctatctttt agacgatgga
     9121 acaggtcgtg tagaagtagg gaatgtcttg atggacaacc aaacaggtgc tattctaggc
     9181 tttgtaggtg gtcgtaatta tcaagaaaat caaaataatc atgcctttga taccaaacgt
     9241 tcgccagctt ctactaccaa gcccttgctg gcctacggta ttgctattga ccagggcttg
     9301 atgggaagtg aaacgattct atctaactat ccaacaaact ttgctaatgg caatccgatt
     9361 atgtatgcta atagcaaggg aacaggaatg atgaccttgg gagaagctct gaactattca
     9421 tggaatatcc ctgcttactg gacctatcgt atgctccgtg aaaagggtgt tgatgtcaag
     9481 ggttatatgg aaaagatggg ttacgagatt cctgagtacg gtattgagag cttgccaatg
     9541 ggtggtggta ttgaagtcac agttgcccag cataccaatg gctatcagac cttagctaat
     9601 aatggagttt atcatcagaa gcatgtgatt tcaaagattg aagcagcaga tggtagagtg
     9661 gtgtatgagt atcaggataa accggttcaa gtctattcaa aagctactgc gacgattatg
     9721 cagggattgc tacgagaagt tctatcttct cgtgtgacaa caaccttcaa gtctaacctg
     9781 acttctttaa atcctactct ggctactgca gattggattg ggaagactgg tacaaccaac
     9841 caagacgaaa atatgtggct catgctttcg acacctagat taaccctagg tggctggatt
     9901 gggcatgatg ataatcattc attgtcacgt agagcaggtt attctaataa ctctaattac
     9961 atggctcatc tggtaaatgc gattcagcaa gcttccccaa gcatttgggg gaacgagcgc
    10021 tttgctttag atcctagtgt agtgaaatcg gaagtcttga aatcaacagg tcaaaaacca
    10081 gggaaggttt ctgttgaagg aaaagaagta gaggtcacag gttcgactgt taccagctat
    10141 tgggctaata agtcaggagc gccagcgaca agttatcgct ttgctattgg cggaagtgat
    10201 gcggattatc agaatgcttg gtctagtatt gtggggagtc taccaactcc atccagctcc
    10261 agcagttcaa gtagtagttc tagcgatagc agtaactcaa gtactacacg accttcttct
    10321 tcaagggcga gacgataatt ctctaaatga agtggccaat caatggattg ccactttttt
    10381 cttttcgtgt tacaataagg gtatgaatca gtatcagaaa aagattgtta acggaaaaat
    10441 ttattcgctc ctatccggct taatatgggg aatctgtgga attttaggag agtacttctt
    10501 tactcattat caggtgtctt cgggctggat tacctctatg cgtttgacac tggcagggag
    10561 tcttgtactc atttggtctg caatacaatt aaaatcgcaa gtgctagata tttggcgaga
    10621 caagaaaaat tacctgccct ttttagccta tgctattttg gggatttttt cagttcagta
    10681 ttttttctat ctctgtgtag aatactcaaa tgctacgaca gcaactattt tacagtttat
    10741 tagccctgtc tttatcctct tttacaatcg cttggtttat caaaaacgag cgtcaaaaag
    10801 cgctgttttc tatgttttgg ttgccatgct gggtgtttgc ttgatggcga caaagggaga
    10861 cctctctcag ttatccatga cgccgctagc tcttataaca ggtttgctga gtgccatggg
    10921 tgttatgttt aatgttatct tgccccaacc ttttgctaag cgttatggtt ttgttcctac
    10981 ggttgggtgg gggatgattt tggcaggttt gtttagcaat gtcctctcgc cggtttatca
    11041 gctttccttt actcttgata tttggagtat cttgatttgc ctcattatcg ctttctttgg
    11101 aacggctttt gcttttttca tttccatgaa ggctgtgtcc ttggtttctc ctttggtggt
    11161 tgccgttatc agtgccagtg aacctctctc ttctgctctc ttgagtgttt tgttcttagg
    11221 attagtagtg gattggtccc tccttctagc tatagccttg attattttac ccatgatatt
    11281 tttgtctata gaagaagcga aagaaagtag ataaaaagtc ttttcttaat tctaaaagtg
    11341 tgctatactg gaatagtcaa taaaacacgg ggagatagtt gtgaagagtg tttttaggtt
    11401 gtatcggtag gggcttgctt ttaccgacag cacgttttat ctcacatccc taaaaaatca
    11461 tacctaaaaa cagacaaaaa ggtttcaaat ttgaggcctt ttttggtaga ataggtatca
    11521 ttataacgaa ccaggaggca cctatgactg ctacaaaaat gaacgctcaa gaaattatcc
    11581 aatttatcgc caatgctgaa aagaaaacca gtgtcaaagt aacctttgag gggcaactcg
    11641 caactgctgt gcctagctct gttgtcaaac taggaaatgt cctattcgga gactggaagg
    11701 acgtggctcc gcttcttgaa ggtttggtag aaaatcaaga ttatgttgtc gagcaagatg
    11761 ctcgtaattc tgcagttcct ttgctagata agcgtgctat caacgctcgt atcgagccag
    11821 gtgctattat ccgtgaccag gtggaaattg gtgacaatgc tgttatcatg atgggagctg
    11881 ttatcaatat cggtgctgaa atcggtgctg gaaccatgat tgacatgggt gc
//
LOCUS       DBMVGT010000053        11721 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.053, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000053 DBMVGT010000000
VERSION     DBMVGT010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 11721)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11721)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11721
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.053"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..656)
                     /locus_tag="AC0DU4_001570"
     CDS             complement(<1..656)
                     /locus_tag="AC0DU4_001570"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001289361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237508.1"
                     /translation="MSEIEIINAKKIYHDVSVIENLNITIPKGSLFTLLGASGCGKTT
                     LLRMIAGFNSIKDGEFYFDDTKINNMEPSKRNIGMVFQNYAIFPHLTVRDNVAFGLMQ
                     KKVPKEELIQQTNKYLELMQIAQYADRKPDKLSGGQQQRVTLACALAVNLSVLLMDEP
                     LSNLEAKLRLDMRQAIREIQHEVGITTVYVTHDQEEAMAISDQIAVMKDGVIQQIGRP
                     "
     gene            complement(669..1670)
                     /locus_tag="AC0DU4_001571"
                     /pseudo
     CDS             complement(669..1670)
                     /locus_tag="AC0DU4_001571"
                     /inference="COORDINATES: protein motif:HMM:NF024808.6"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
     gene            complement(2008..2232)
                     /locus_tag="AC0DU4_001572"
                     /pseudo
     CDS             complement(2008..2232)
                     /locus_tag="AC0DU4_001572"
                     /inference="COORDINATES: protein motif:HMM:NF024242.6"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
     gene            complement(2280..3056)
                     /locus_tag="AC0DU4_001573"
     CDS             complement(2280..3056)
                     /locus_tag="AC0DU4_001573"
                     /EC_number="1.97.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000406168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0043687 - post-translational protein
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HIN4237509.1"
                     /translation="MEISKGIIFNIQHFSIHDGPGIRTTVFLKGCPLRCPWCSNPESQ
                     RMKPEKMKDAQREKFTLVGEEKTVEEIITEVLKDKEFYEESGGGLTLSGGEIFAQFEF
                     AKAILKSAKEHHIHTAIETTAFVDHEKFIDLIQYVDFIYTDLKHYNSIKHKKVTGVFN
                     QMIIKNIHYAFSQNKTIVLRIPVIPNFNNSLEDAEKFATLFNSLNIDQVQLLPFHQFG
                     ENKYRLLNRKYEMDGVNALHPEDLIDYQKVFLNHHINCYF"
     gene            3178..3924
                     /locus_tag="AC0DU4_001574"
     CDS             3178..3924
                     /locus_tag="AC0DU4_001574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000824973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="HIN4237510.1"
                     /translation="MKRLEQIIKLVSEYEKIDVNTLSEKLNVSKVTIRKDLDKLESKG
                     LLHREHGYAVLNSGDDLNVRLSINYEIKRKIVQEAVKLVSDNETIMIESGSTCALLAE
                     EICKQKRNVTIVTNSFFIANFVRAYDSCRIIVLGGEFQKDSQVTVGPLLKEMIQTFHV
                     HQAFVGTDGYDKEMGFTGKDLMRSEVVQYISAASDKVIVLTDSSKFDKRGTVRRFALS
                     QVYEVITDEKLSKQNIATLENAGIMVKVVS"
     gene            3937..4917
                     /locus_tag="AC0DU4_001575"
     CDS             3937..4917
                     /locus_tag="AC0DU4_001575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001070834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0030246 - carbohydrate binding [Evidence
                     IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="HIN4237511.1"
                     /translation="MNQDRNKLLSKIAYLYYIENLNQSQIAAKLGIYRTSISRMLTEA
                     RNAGIVKIEIENFDTNMFKLENYVKEKYGLESLEIIPNEFDDNPTILSERISQVAAGV
                     LRNLIDDNMKIGFSWGKSLSNLVDLIHSKSVRNVHFYPLAGGPSHIHAKYHVNTLIYE
                     MSRKFHGECTFMNATIVQENKLLADGILQSRYFENLKNSWKDLDIAVVGIGDFSNKGK
                     HQWLDMLTEDDFKELTKVKTVGEICCRFFDSKGKEVYENLQERTIAISLEDLKNIPQS
                     LAVAYGDTKVSSILSVLRANLVNHLITDKNTILKVLEEDGDLTFREILGE"
     gene            5112..5432
                     /locus_tag="AC0DU4_001576"
     CDS             5112..5432
                     /locus_tag="AC0DU4_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HIN4237512.1"
                     /translation="MEIIVPDQIIMGLILYAGDAKQHIYKALDYIKNGTCERCEEEIQ
                     LADAALLEAHNLQTKFLAQEASGTKTEITALFVHSQDHLMTSMTEINLIKEIISLRKE
                     LHKK"
     gene            5478..5786
                     /locus_tag="AC0DU4_001577"
     CDS             5478..5786
                     /locus_tag="AC0DU4_001577"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000238716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4237513.1"
                     /translation="MVKIGLFCAAGFSTGMLVNNMKIAAQASGVEAEIEAFSQSKLAD
                     YAPNIDVALLGPQVAYTLDKSKEICDKCDVPIAVIPMMDYGMLDGKKVLDLALSLISG
                     "
     gene            5803..7101
                     /locus_tag="AC0DU4_001578"
     CDS             5803..7101
                     /locus_tag="AC0DU4_001578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000041357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HIN4237514.1"
                     /translation="MAKMDVQKIIAPMMKFVNMRGIIALKDGMLAILPLTVVGSLFLI
                     MGQLPFEGLNKSIASVFGANWTEPFMQVYSGTFAIMGLISCFSIAYSYAKNSGVEALP
                     AGVLSVSAFFILLRSSYIPKQGEAIGDAISKVWFGGQGIIGAIIIGLVVGSIYTFFIK
                     RKIVIKMPEQVPQAIAKQFEAMIPAFVIFLLSMIVYILAKSLTNGGTFIEMIYSAIQV
                     PLQGLTGSLYGAIGIAFFISFLWWFGVHGQSVVNGVVTALLLSNLDANKAMLASGNLS
                     LENGAHIVTQQFLDSFLILSGSGITFGLVVAMLFAAKSKQYQALGKVAAFPAIFNVNE
                     PVVFGFPIVMNPVMFVPFILVPVLAAVIVYGAIATGFMQPFSGVTLPWSTPAILSGFL
                     VGGWQGVITQLVILAMSTLVYFPFFKVQDRLAYQNEIKQS"
     gene            7252..9690
                     /locus_tag="AC0DU4_001579"
     CDS             7252..9690
                     /locus_tag="AC0DU4_001579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HIN4237515.1"
                     /translation="MVNTEVARTTIKTEYFGRLTERMNKYREDVLNKKPYIDAERAVL
                     ATRAYERYKEQPNVLKRAYMLKEILENMTIYIEEESMIGGNQASSNKDAPIFPEYTLE
                     FVLNELDLFEKRDGDVFYITEETKEQLRSIAPFWENNNLRARAGALLPEEVSVYMETG
                     FFGMEGKMNSGDAHLAVNYQKLLQFGLRGFEERARKAKAALDLTDPASIDKYHFYDSI
                     FIVIDAIKVYAKRFVALAKSLAENANPKRKKELLEIADICSRVPYEPVTTFAEAIQSV
                     WFIQCILQIESNGHSLSYGRFDQYMYPYMKADLESGKETEDSIVERLTNLWIKTITIN
                     KVRSQSHTFSSAGSPLYQNVTIGGQTRDKKDAVNPLSYLVLKSVAQTHLPQPNLTVRY
                     HAGLDARFMNECIEVMKLGFGMPAFNNDEIIIPSFIAKGVLEDDAYDYSAIGCVETAV
                     PGKWGYRCTGMSYMNFPKVLLITMNDGIDPASGKRFAPSFGHFKDMKNFSELENAWDK
                     TLRYLTRMSVIVENSIDLSLEREVPDILCSALTDDCIGRGKHLKEGGAVYDYISGLQV
                     GIANLSDSLAAIKKLVFEEERISPSQLWHALETDYAGEEGKVIQEMLIHDAPKYGNDD
                     DYADKLVTAAYDIYVDEIAKYPNTRYGRGPIGGIRYSGTSSISANVGQGRGTLATPDG
                     RNAGTPLAEGCSPSHNMDQHGPTSVLKSVSKLPTDEIVGGVLLNQKVNPQTLAKEEDK
                     LKLIALLRTFFNRLHGYHIQYNVVSRETLIDAQKHPEKHRDLIVRVAGYSAFFNVLSK
                     ATQDDIIGRTEHTL"
     gene            9709..10377
                     /locus_tag="AC0DU4_001580"
     CDS             9709..10377
                     /locus_tag="AC0DU4_001580"
                     /EC_number="4.1.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HIN4237516.1"
                     /translation="MEFMLDTLNLDEIKKWSEILPLAGVTSNPTIAKREGSINFFERI
                     KDVRELIGSTPSIHVQVISQDFEGILKDAHKIRRQAGDDIFIKVPVTPAGLRAIKALK
                     KEGYHITATAIYTVIQGLLAIEAGADYLAPYYNRMENLNIDSNSVIRQLALAIDRQNS
                     PSKILAASFKNVAQVNNALAAGAHAVTAGADVFESAFAMPSIQKAVDDFSDDWFVIQN
                     SRSI"
     gene            10395..11483
                     /locus_tag="AC0DU4_001581"
     CDS             10395..11483
                     /locus_tag="AC0DU4_001581"
                     /EC_number="1.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0008888 - glycerol dehydrogenase (NAD+)
                     activity [Evidence IEA];
                     GO_function: GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol dehydrogenase"
                     /protein_id="HIN4237517.1"
                     /translation="MRIFASPSRYIQGENALFENAKSILDLGNCPILLCDQLVYDIVG
                     KRFEDYLHRYGFHIVLALFNGEASDNEINRVVALAEKENCDSIIGLGGGKTIDSAKAI
                     ADLIEKPVIIAPTIASTDAPVSALSVIYTDEGAFDHYLFYSKNPDLVLVDTKVISQAP
                     KRLLASGIADGLATWVEARAVMQANGKTMLGQQQTLAGVAIAKKCEETLFADGLQAMA
                     ACEAKVVTPALENIVEANTLLSGLGFESGGLAAAHAIHNGFTALIGDIHHLTHGEKVA
                     YGTLVQLLLENRPKEELDKYIEFYKKIGMPTTIKEMHLDQVGYDDLIKVGKQATMEGE
                     TIHQMPFKISPSDVAQAIIAVDAYVNSK"
BASE COUNT         3776 a         1706 c         2321 g         3918 t
ORIGIN      
        1 tttggtcggc cgatttgttg gatcacccca tctttcataa cagcaatttg gtctgaaata
       61 gccatggctt cttcttggtc gtgggttaca taaacagttg taattcccac ttcgtgttgg
      121 atttctcgga tggcttgacg catatccaag cgaagtttgg cctccagatt actaagtggc
      181 tcgtccatga ggagaacact tagattaacc gctaaggcgc atgccaaggt gacacgttgt
      241 tgttgtccac cactgagttt atcgggcttt cgatccgcat attgagcaat ttgcatgagt
      301 tcaagatact tgttggtctg ttgaatcaat tcttcttttg gaaccttctt ttgcataaga
      361 ccaaaagcaa cgttgtctcg gacagtcaaa tgtgggaaaa tagcgtagtt ttggaaaacc
      421 atcccgatat tgcgtttgct gggttccata ttattgattt ttgtatcatc gaagtaaaat
      481 tctccatctt tgatactgtt gaaacctgca atcatacgaa gaagggtcgt tttcccacat
      541 cctgaagctc caagaagggt aaagagactt ccttttggaa ttgtaatgtt caaattctca
      601 ataacagaga catcgtggta gatttttttg gcgttaataa tttcgatctc actcatagtg
      661 aacctctttt actgtttaga ttggatatct gtaaagactt cgttgtattt cttaacgata
      721 tctgatttat tcttgatgac ataatcataa tcttcagtga gtgttttgat tttgtcaatt
      781 ggtttcatgt tttcgcttgt tttagcattt ttacgaacag gacggttagt agtggttgta
      841 ccaagtgtat cttgtacttc ttgagagata ataaaatcga taaatttctt ggcattttcc
      901 atatttttag attttttaac gatagcagca ctagcaggta ggaagacggt tccttctttt
      961 ggatagacta ccttaatgtt agctccgtca tttaagagtt taactgctgg atcttcataa
     1021 gagagaccaa cagtcatttc tccatcagcg actgctttat agacaccaga tgaacttaaa
     1081 ccgattttat agtatattga aactagaata gtacacatct acttctaaaa cattgttaga
     1141 aatcgatttg actgtcctga ttaatttgtc ctgttcttat ttcattttac tataccatca
     1201 ataagtgtga aaagatcttt tacataagac caagccttat catctttgta accaccttga
     1261 gcttgtagca tatttgttaa ttgagcaaag gcgctagaag agtttgctgg gtcagcagtt
     1321 gcgatttttc cttttagttc aggtttgaga aggtcgctat atccttcgat gttcatgcct
     1381 ttagttaaat cagggtggac gattaaaaca ctaccatcta gtgtataagg agtagagaag
     1441 ccagttgtgt tttgatattc tttgataaca ttatcatttt cttttgaagt atagttttca
     1501 aagagttctc cgtgggtagc atattgtgta taagaaccac caaagataac atcagctaca
     1561 ggaacttctt tttctgactc tagttttttg aaaagttctc cagtaccagc ttgaatcagt
     1621 tctactttga taccatattt ttcttcaaag gcaggaatag ttgctccaat taagtcctct
     1681 gagtttggtc aataaacgac tagcgaacca ccgtctcctt tatcagatga actgtcatcg
     1741 gcagattcat tagaagaaca agcagcataa tacatccatt tctttttcat gatgggatat
     1801 ctccgttgtg ttatttaagt ttattttaaa acaatgtaag cgtttttaaa acctacaatt
     1861 ctattctata gtgtattgaa tctataacag tacactttga ctgctaaaat atttctataa
     1921 attaatttga ctttcctgat agagatgttc acatcttatt tcaattcact atattagagt
     1981 aaaattctct acaaaaagaa gaatagccta ttttactatt cttccgagtg atttcaattt
     2041 ctttggggaa atatggagat actttttaaa tactttggca aaatatttat agtctgaaaa
     2101 tccaacttgg tcagagatag cgcttaaagg ggagttggga gattcagcca tcttatctat
     2161 agcttgtttc aggcgatatt gtaagatata ttcatttaga gtcatgggga agtcttcttt
     2221 gataacctta tatagatgct tgttatctgc aaatagctag agcatttcaa ggaaatgaac
     2281 tagaaataac aattaatatg gtggttcaga aatacctttt gataatcaat aagatcttca
     2341 ggatgaagtg cgttgactcc atccatttca tatttccgat ttaataaacg atatttgttt
     2401 tcaccaaatt gatgaaaagg gagtagttga acttggtcga tatttaatga gttaaataga
     2461 gtagcgaatt tttctgcatc ctctaaacta ttgttaaaat taggaataac tgggattctt
     2521 aaaacgatag ttttattttg agaaaaagca taatgaatgt ttttaataat catttgatta
     2581 aaaaccccag tcactttttt atgttttata gaattataat gttttaggtc tgtgtagata
     2641 aaatccacat attgaattaa atcgataaat ttttcatgat caacaaaggc agtagtttca
     2701 atggcagtgt gtatgtgatg ttctttagct gattttaaga tggctttagc aaattcaaac
     2761 tgagcaaata tttcacctcc tgataaagtt aaacctccac cggattcttc gtaaaattct
     2821 ttgtctttta atacctctgt aataatttct tctacagtct tttcttcacc gactaaggtg
     2881 aatttctctc gttgagcatc tttcattttt tcaggtttca ttctttgaga ttcaggatta
     2941 gaacaccatg gacagcgcag aggacatcct tttaaaaaaa cagttgtacg aatacccggg
     3001 ccgtcatgaa ttgaaaagtg ttgaatatta aaaataattc ctttagatat ttccataaga
     3061 gttcctcctc ttcataagtc tatcctatca caaaaacgaa agaaaaacaa ttacgaacga
     3121 aaggttgatt tgttgttttt tgctttttat tttggtagaa taaaacggag gtgtaaaatg
     3181 aaaagattgg aacaaattat taaattagta tcagaatatg aaaagatcga cgttaataca
     3241 ttatcggaaa aattaaatgt atcgaaagta acgattagaa aagatttaga taaattagag
     3301 tcaaaaggtt tattacacag agagcatgga tatgctgtat taaatagtgg agatgactta
     3361 aatgtacgtt tgtcaattaa ttatgaaatt aagagaaaaa ttgttcagga agcagtaaaa
     3421 ttggtgtcag ataatgaaac aataatgata gaatctggat cgacctgtgc tttacttgct
     3481 gaggaaattt gcaagcaaaa aagaaatgtt acgattgtaa caaattcatt ttttatagca
     3541 aattttgtga gagcttatga ttcatgtcgt attattgttc ttggtggaga gtttcagaag
     3601 gattcacagg ttactgtggg acctttatta aaagaaatga tacagacttt tcatgtgcat
     3661 caagcttttg ttgggacaga tggttacgat aaagagatgg gctttacagg aaaagattta
     3721 atgcgcagtg aggtagttca atatatttca gcagcgtcgg ataaagtcat tgtactaact
     3781 gactcaagta aatttgataa aaggggtaca gtaagaagat ttgctttaag tcaagtctat
     3841 gaagtaataa cagacgaaaa actttctaaa caaaatatag ctacattaga aaatgctggg
     3901 ataatggtta aggtagtttc gtaagaggtt aagtgtatga atcaagatag gaataaactg
     3961 ctctctaaaa ttgcttatct gtattatatt gaaaacttaa atcagtcaca aatagcagca
     4021 aaattaggaa tttatagaac ctctattagt agaatgttaa cagaagcaag gaatgcagga
     4081 attgttaaaa ttgaaataga gaattttgat acaaatatgt ttaagttgga aaattatgta
     4141 aaagaaaaat atggtctgga aagtttagaa attattccaa atgaatttga tgataatcca
     4201 acaattttat ctgaaagaat ttctcaagtt gcagcaggtg tccttaggaa tttaattgat
     4261 gataatatga aaattggctt ttcttggggg aaaagtttaa gtaatttagt agatttaatt
     4321 cacagtaaaa gtgtccgaaa tgttcacttc tatcctctag caggtggtcc tagtcacata
     4381 cacgctaaat accatgtgaa tacactgatt tatgaaatgt ctagaaaatt tcatggagag
     4441 tgtacattta tgaatgcaac gattgtgcaa gaaaataaat tgttagcaga tggtattttg
     4501 caatcaagat attttgaaaa tttgaaaaat agttggaaag atttagatat agctgtagtc
     4561 ggaattggtg attttagcaa taaaggaaaa catcaatggt tagacatgct tacagaggat
     4621 gactttaaag aattgaccaa agttaaaact gtaggagaaa tttgttgtcg attttttgat
     4681 tcaaaaggta aagaagtcta tgaaaactta caggaaagaa cgatagcaat ctctttggaa
     4741 gatttaaaaa atattcctca aagtttagct gttgcttacg gtgatacgaa agtatcttcg
     4801 attctttctg tcttgcgtgc taatttagta aatcatttga ttacagacaa aaatacaatt
     4861 ttaaaagttt tggaagaaga tggggatttg acttttagag agattctagg tgagtgaaaa
     4921 tgatagactg attcagttta tcgtttttct ttttagttga ttgcacattt gtgcttatat
     4981 aaacaaaaat agtttatctg ttgtttttgg attgacaact ttattatgta gttgtattct
     5041 atagttacaa aagaaaattt taaaatttca aatgaaaaaa gctttttaca tagtgaaatg
     5101 aggaggaatt tatggaaatt attgttccag atcaaattat catgggttta attttatatg
     5161 ctggcgatgc gaaacaacat atttataaag cgttagatta cataaaaaat ggtacatgtg
     5221 aacgatgtga agaagaaatc cagttagctg atgcagcctt attagaagct cataatctac
     5281 aaacaaaatt cttggcacag gaagcgtctg gtacaaagac agaaattaca gctctctttg
     5341 ttcattcaca agatcatctc atgactagta tgacggagat taatttaatc aaagaaatta
     5401 ttagtttgag aaaagaactt cataaaaaat aatactagag tattatcatt gttattaaca
     5461 tagaggagga aaacataatg gtgaagattg gtttgttttg tgcagcaggt ttttctactg
     5521 gtatgcttgt aaataatatg aaaattgcag cgcaagctag tggagttgag gcagaaatag
     5581 aggcgttttc tcagtctaaa ttagcggatt atgcgccaaa tatagatgtt gcactattgg
     5641 gtccacaagt tgcttataca ttagataaat caaaagaaat ttgtgataag tgtgatgttc
     5701 cgatagctgt tattccgatg atggactatg gtatgttaga tgggaaaaaa gtattagatt
     5761 tggccctatc tttgattagt gggtaagaaa aggagattta ttatggcaaa gatggatgtt
     5821 cagaaaatca ttgcaccgat gatgaagttt gtgaatatgc gtggcattat agctctaaaa
     5881 gatgggatgt tagcaatttt gccattgaca gtagttggta gtttattctt gattatggga
     5941 caattgccgt tcgaaggatt aaataagagc attgctagtg tttttggagc taattggaca
     6001 gagccgttta tgcaagtata ttcaggaact tttgctatta tgggtctaat ttcttgtttt
     6061 tcaattgcct attcttatgc taagaatagc ggagtagagg ctttaccagc tggagttcta
     6121 tctgtatctg cattctttat tttgctaaga tcatcttata tccctaaaca aggtgaggca
     6181 attggggatg ctattagtaa agtttggttt ggaggtcaag gaattatcgg tgctatcatt
     6241 ataggtttgg tagtaggaag tatttatacc ttctttataa agagaaaaat tgttattaag
     6301 atgccagaac aagttccaca agctattgcc aaacagtttg aagcaatgat tccagcattt
     6361 gtaattttct tactttctat gattgtatat attttagcga agtcattgac taatggcgga
     6421 acattcatag aaatgattta ttctgctatt caagttccat tgcaaggttt aactggatct
     6481 ttgtatggtg ctattggaat tgcattcttt atatcatttt tgtggtggtt tggtgttcat
     6541 ggacaatcgg tagtaaatgg agtagtgaca gctctgcttt tatctaatct tgatgctaat
     6601 aaagctatgt tagcctctgg taatctatca ttagaaaatg gtgcacatat tgttactcaa
     6661 caatttttag attcattttt aattctatca ggttcaggga ttacgtttgg tcttgtagtt
     6721 gccatgcttt ttgcagcaaa atcaaaacaa taccaagcct taggaaaagt tgccgctttt
     6781 ccagcaatat ttaacgtaaa tgagccagtt gtatttggat ttccgattgt catgaatcca
     6841 gttatgtttg tacctttcat tcttgttcct gtacttgcag ctgtgatagt atatggagct
     6901 attgcaacag gtttcatgca gccattctca ggggtaacat tgccttggag tacaccagct
     6961 attttatcag gatttttggt gggtggatgg caaggagtta ttactcagct ggtgatatta
     7021 gcgatgtcta cattggttta ttttccattc tttaaagtac aggatcgttt agcttaccaa
     7081 aatgaaatca aacaatctta gaggtatttg tgtgttactg ttaaactcac acatttgtgc
     7141 taaaaattag agagttaaaa tttttctagt taaaagcttg aaaatttcta taaaaatcgg
     7201 tattatattt tcgaaagaaa taaaaatatt ttcgaaagaa aggtggttac gatggtaaat
     7261 acagaagtag caagaacaac aatcaagaca gaatattttg gcagacttac tgaaaggatg
     7321 aacaaatatc gagaagatgt tttaaataaa aaaccttata ttgatgctga gagagcagtt
     7381 ctagcaacac gcgcctatga acgatacaag gaacaaccta atgtcctaaa acgtgcatat
     7441 atgctgaaag aaattttgga aaatatgact atctatattg aagaagaatc tatgattggg
     7501 ggaaatcaag cttcttccaa taaagatgct cctatttttc cggaatatac gctagaattt
     7561 gttctcaatg agttggatct ttttgaaaag cgtgatggag atgttttcta tattacagaa
     7621 gaaacaaaag aacaacttag aagtattgct ccgttttggg aaaataataa tttacgtgct
     7681 agagctggtg ccttattacc tgaagaagtg tctgtttata tggaaacagg attcttcggt
     7741 atggaaggta agatgaattc tggagatgct cacctagcag ttaactatca gaaacttttg
     7801 caatttggct taagaggttt tgaagagcgg gctcgtaaag caaaagcagc tctagattta
     7861 acagatccag caagtattga taaatatcat ttttacgact ctatatttat cgtaatcgat
     7921 gctattaaag tatatgcaaa gcgctttgtt gctcttgcta aaagtttagc cgaaaatgca
     7981 aatcctaaac gtaagaaaga attacttgag attgcagata tttgctctag agtcccatat
     8041 gaaccggtaa ctacttttgc agaagctatt caatcagttt ggtttattca atgtatttta
     8101 caaattgaat ctaatggcca ctctctttca tatggccgtt ttgatcaata tatgtatcca
     8161 tatatgaagg ctgatttaga aagtggtaaa gaaacagaag atagcattgt tgaacgtctg
     8221 acaaatcttt ggattaagac aattacaatt aataaggttc gcagtcaatc acatacattt
     8281 tcttcagcag gaagtccttt atatcaaaat gttacaattg gtggacagac tcgagataag
     8341 aaggatgctg ttaacccatt atcttatttg gtattaaaat cagttgcaca aacccatcta
     8401 ccgcaaccta atctaactgt acgttaccat gcaggtttag atgctcgttt catgaatgag
     8461 tgtattgaag tgatgaaact tggttttggt atgcctgcat ttaataatga tgagattatt
     8521 attccttctt ttattgcaaa aggagtattg gaagatgatg cttatgatta cagtgccatt
     8581 ggatgtgttg aaacggcagt tccagggaaa tggggctatc gttgcacagg tatgagttat
     8641 atgaacttcc ctaaggttct acttatcacg atgaatgatg gaattgatcc ggcttcgggt
     8701 aaacggtttg caccaagctt tggtcatttt aaggatatga agaacttttc tgaattagaa
     8761 aatgcttggg ataaaacact aagatatttg acacgaatga gtgttattgt tgaaaattct
     8821 attgatttat cattggaacg agaagttcct gatattctat gttcagcatt gactgatgat
     8881 tgtattggtc gtggaaaaca ccttaaagaa ggtggagcag tatatgatta tatatcagga
     8941 ttgcaagttg gaattgcaaa tttgtcggat tcattagctg caattaaaaa attggtgttt
     9001 gaggaagaac gtataagccc aagtcagctt tggcatgcac tggaaacaga ttatgccgga
     9061 gaagaaggta aggtcattca agaaatgttg attcatgatg cacctaagta tggtaatgat
     9121 gatgattatg ctgacaaatt ggttactgct gcttatgaca tttatgttga tgaaattgct
     9181 aaatatccta atacacgtta tggaagaggt ccaattggag gaattcgtta ttcaggaaca
     9241 tcttctatct cagccaacgt agggcaggga cgtggaacat tagcaactcc agatggacgc
     9301 aacgcgggta caccgttagc agagggttgt tcaccatcac ataatatgga tcaacacggc
     9361 cctacatctg ttttaaaatc tgtttcaaaa ttaccaacag atgaaatcgt aggtggggtt
     9421 ctcttaaatc agaaagtaaa tcctcaaacg ttagccaaag aagaagataa attaaaacta
     9481 attgctttgt tacgaacatt ctttaatcgt ttacatgggt accatattca atacaatgtt
     9541 gtttccagag agacgctgat tgacgctcag aaacatcctg aaaaacacag agacttaatt
     9601 gttcgtgttg caggatactc tgcattcttc aatgttcttt ctaaggcaac ccaagatgac
     9661 attataggac gtactgagca tactttgtaa aataaagagg ttctttttat ggaatttatg
     9721 cttgacacat taaatttaga tgagattaaa aagtggtctg aaattttgcc gctagctggg
     9781 gtaacttcaa atcccactat tgcaaaaaga gagggttcta ttaatttttt tgaacgaatc
     9841 aaagatgtaa gagaattgat tggctctaca ccctctattc atgttcaggt gatttctcaa
     9901 gattttgaag gcatcttaaa ggatgctcat aaaattcgaa gacaagcagg agatgatata
     9961 tttatcaaag tacctgttac tccagctgga ttacgtgcaa taaaggcgct aaaaaaagag
    10021 ggctaccata tcactgcaac agctatttat acagttattc agggattatt agctatcgaa
    10081 gcaggagcgg attacctagc tccatattat aatagaatgg aaaatctgaa cattgattca
    10141 aattctgtca ttcgtcaatt agctcttgct attgatagac agaactctcc tagtaagatt
    10201 ttagctgcat cctttaaaaa tgtagcacaa gtaaataatg ctttagctgc aggtgcgcat
    10261 gctgttacag caggagcgga tgtttttgaa tcagctttcg ccatgccatc tatccaaaag
    10321 gcggttgatg atttttctga cgattggttt gttattcaaa atagtcgttc catttagata
    10381 gagaggaaat acatatgaga atttttgcta gtccttctag atatattcag ggggaaaatg
    10441 ccttgtttga aaatgccaaa tcaattttgg atttgggaaa ttgccctatt ctattatgcg
    10501 atcagttggt ttatgatatt gttggaaaac gatttgaaga ttatctacat aggtatggtt
    10561 tccatattgt tctggcgcta tttaatggtg aagcttctga caatgaaatc aatcgagttg
    10621 ttgccttggc tgagaaagaa aattgtgata gtattatcgg tcttggtggg ggaaagacga
    10681 ttgatagcgc aaaagctatt gcagatttga ttgaaaagcc tgttattatt gctccaacaa
    10741 ttgcatcgac cgacgcacct gtatctgctt tatctgttat ttatacagat gaaggtgcat
    10801 ttgatcatta tctattttat tctaaaaatc cagatttagt tttggttgat acaaaagtta
    10861 tttcacaagc ccctaagcgt ttattagcgt ctggtattgc agatggttta gcaacttggg
    10921 ttgaggcgcg tgcggttatg caggcaaatg gaaaaactat gttgggacaa cagcaaacat
    10981 tggctggagt tgcaattgcg aagaaatgtg aagaaacgct gtttgcagat ggtttacagg
    11041 ctatggcagc ttgtgaagct aaagtggtga caccagcatt agaaaatatt gttgaagcta
    11101 atactttatt gagtggtcta ggttttgaaa gtggaggatt agctgcggcg catgcaattc
    11161 ataatggttt tactgcattg ataggtgaca ttcatcattt aacacatggt gaaaaagtag
    11221 cttatggaac tttagtacaa ctattattgg aaaatagacc taaagaagaa cttgataagt
    11281 atattgagtt ttacaaaaaa attggtatgc caacaactat aaaagaaatg catttggatc
    11341 aagttggata tgatgattta ataaaagttg gtaaacaagc aactatggag ggtgagacaa
    11401 ttcatcagat gccgtttaag atttcgcctt cagatgttgc tcaagctatt atcgctgtag
    11461 atgcctatgt aaattcaaaa taaacaataa ggactactgt tttccaaatg gtagtctttt
    11521 attgatcctc gtattgaatt ctatagcaga ttgaaataag atgagaacaa atcgattggg
    11581 aaagtaaaat taatttctat aagtgtttta gcaattgttt cgtactattt cagattcagt
    11641 ctactatacg ttcttcataa atcaaaaagc gacataggtt gtcggctatt tattgtgaat
    11701 acattaatta gccccaatta t
//
LOCUS       DBMVGT010000054        11645 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.054, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000054 DBMVGT010000000
VERSION     DBMVGT010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 11645)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11645)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11645
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.054"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..312
                     /gene="nadE"
                     /locus_tag="AC0DU4_001582"
     CDS             <1..312
                     /gene="nadE"
                     /locus_tag="AC0DU4_001582"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008795 - NAD+ synthase activity [Evidence
                     IEA];
                     GO_process: GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(+) synthase"
                     /protein_id="HIN4237518.1"
                     /translation="TKFGDGGADILPLYRLNKRQGKQLLQKLGAEPALYEKIPTADLE
                     EDKPGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFW
                     E"
     gene            609..1160
                     /locus_tag="AC0DU4_001583"
     CDS             609..1160
                     /locus_tag="AC0DU4_001583"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4237519.1"
                     /translation="MKSIGTQILQTERLILRRFVESDAEAMFQNWASSAENLTYVTWD
                     PHPDVEITRNSIRNWVASYTNLNYYKWAICLKENPEQVIGDISIVKIDEADLSCEIGY
                     VLGKAYWGHGMMTEALKAVLDFCFTQAGFQKVRARYASLNPASGRVMEKAGMSYLQTI
                     VNGVERKGYLADLIYYGISREEC"
     gene            2204..2425
                     /locus_tag="AC0DU4_001584"
     CDS             2204..2425
                     /locus_tag="AC0DU4_001584"
                     /inference="COORDINATES: protein motif:HMM:NF019142.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HIN4237520.1"
                     /translation="MKVPAKSKVEEVLVPFATKYEADNDLSAGQEQEITLGKNGKTVT
                     TITYNVDGKSGQVTESTLSQKKRLSNKSC"
     gene            2621..3010
                     /locus_tag="AC0DU4_001585"
     CDS             2621..3010
                     /locus_tag="AC0DU4_001585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HIN4237521.1"
                     /translation="MVKRRIRRGTREPEKVVVPEQSSIPSYPVSVTSNQGTDVAVEPA
                     KAVAPTTDWKQENGMWYFYNTDGSMATGWVQVNGSWYYLNSNGSMKVNQWFQVGGKWY
                     YVNASGELAVNTSIDGYRVNDNGEWVR"
     gene            complement(3671..4699)
                     /gene="queA"
                     /locus_tag="AC0DU4_001586"
     CDS             complement(3671..4699)
                     /gene="queA"
                     /locus_tag="AC0DU4_001586"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_function: GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HIN4237522.1"
                     /translation="MNTADFDFHLPEELIAQTPLEKRDASKLLIVNRETGEMQDKHFH
                     SIIDMLEPGDALVMNDTRVLPARLYGQKVETGGHVELLLLKNTSGDEWEVLAKPAKRL
                     KVGTRISFGDGRLSAVVTEELTHGGRIVRFEYQGIFLEVLESLGEMPLPPYIHEKLDD
                     RERYQTVYAKESGSAAAPTAGLHFTKELLAEIQAKGVHLVYLTLHVGLGTFRPVSVDN
                     LDEHEMHSEFYQLSEEAAATLRSVKENGGRVIAVGTTSIRTLETIGSKFDGQIQADSG
                     WTNIFIKPGYEWKVVDAFSTNFHLPKSTLVMLVSAFAGRELVLDAYHHAIQEHYRFFS
                     FGDAMFIY"
     gene            4850..5557
                     /locus_tag="AC0DU4_001587"
     CDS             4850..5557
                     /locus_tag="AC0DU4_001587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HIN4237523.1"
                     /translation="MKVIKVENQVQGGKVAFEILKEKLANGAQTLGLATGSSPLEFYK
                     EIVESDLDFSNLTSVNLDEYVGLDGDNPQSYRYFMQENLFNQKPFKESFLPRGVKDNA
                     EAEVERYNQILADHPVDLQILGIGRNGHIGFNEPGTPFDSQTHLVELDQSTIEANARF
                     FAKIEDVPTQAISMGIKNILDAKSIILFAYGESKAEAIAGTVSGPVTENLPASSLQNH
                     PDVTIIADAEALSLLEK"
     gene            5635..6144
                     /locus_tag="AC0DU4_001588"
     CDS             5635..6144
                     /locus_tag="AC0DU4_001588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237524.1"
                     /translation="MNKEEFLKIKEAYKSARTEERKSIIGFITKKKDKEGNFLFTKSK
                     DKPYTTRNQYSGGGGNKKYTSGSRLSRPYDLSNHMWIDLSYKGNDILISLQSFDIDPN
                     SKELHVLYDRIGILFEQSKKIPIFKDCYTITKVSDAFLKMETTNWELPLSKADMEEMV
                     NYIINHYEE"
     gene            6224..6400
                     /gene="rpsU"
                     /locus_tag="AC0DU4_001589"
     CDS             6224..6400
                     /gene="rpsU"
                     /locus_tag="AC0DU4_001589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HIN4237525.1"
                     /translation="MSKTVVRKNESLDDALRRFKRAVTKAGTLQETRKREFYEKPSVK
                     RKRKSEVARKRKKF"
     gene            6530..7465
                     /gene="hprK"
                     /locus_tag="AC0DU4_001590"
     CDS             6530..7465
                     /gene="hprK"
                     /locus_tag="AC0DU4_001590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0006109 - regulation of carbohydrate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HPr(Ser) kinase/phosphatase"
                     /protein_id="HIN4237526.1"
                     /translation="MSVLVKEVIEKLRLDIVYGEPELLEKEINIADITRPGLEMTGYF
                     DYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAA
                     RECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKS
                     ETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGAS
                     AVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIE
                     AAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA"
     gene            7458..8246
                     /gene="lgt"
                     /locus_tag="AC0DU4_001591"
     CDS             7458..8246
                     /gene="lgt"
                     /locus_tag="AC0DU4_001591"
                     /EC_number="2.5.1.145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008961 -
                     phosphatidylglycerol-prolipoprotein diacylglyceryl
                     transferase activity [Evidence IEA];
                     GO_process: GO:0009249 - protein lipoylation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HIN4237527.1"
                     /translation="MLDPIAIQLGPLAIRWYALCIVTGLILAVYLTMKEAPRKKIIPD
                     DILDFILVAFPLAILGARLYYVIFRFDYYSQNLGEIFAIWNGGLAIYGGLITGALVLY
                     IFADRKLINTWDFLDIAAPSVMIAQSLGRWGNFFNQEAYGATVDNLDYLPGFIRDQMY
                     IEGSYRQPTFLYESLWNLLGFALILIFRRKWKSLRRGHITAFYLIWYGFGRMVIEGMR
                     TDSLMFFGLRVSQWLSVVLIGLGIMIVIYQNRKKAPYYITEEEN"
     gene            8247..8630
                     /locus_tag="AC0DU4_001592"
     CDS             8247..8630
                     /locus_tag="AC0DU4_001592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
                     /protein_id="HIN4237528.1"
                     /translation="MLEVAYILVALALIVFLVYLIITVQKLGRVIDETEKTIKTLTSD
                     VDVTLHHTNELLAKVNVLADDINVKVATIDPLFSAVADLSLSVSDLNDHARVLSKKAS
                     SAGSKTLKTGASLSALRLASKFFKK"
     gene            8646..9035
                     /locus_tag="AC0DU4_001593"
     CDS             8646..9035
                     /locus_tag="AC0DU4_001593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HIN4237529.1"
                     /translation="MGKLSSILLGTVSGAALALFLTSDKGKQVCSQAQDFLDDLREDP
                     EYAKEQVCEKLTEVKEQATDFVLKTKEQVESGEITVDSILAQAKSYAFQATEASKNQL
                     NNLKEQWQEKAEALDDSEEIVIHITEE"
     gene            9119..10249
                     /gene="hemW"
                     /locus_tag="AC0DU4_001594"
     CDS             9119..10249
                     /gene="hemW"
                     /locus_tag="AC0DU4_001594"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA];
                     GO_function: GO:0051989 - coproporphyrinogen dehydrogenase
                     activity [Evidence IEA];
                     GO_process: GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="radical SAM family heme chaperone HemW"
                     /protein_id="HIN4237530.1"
                     /translation="MQKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDSYLEHLLEE
                     FRSYDIEKLSTLYIGGGTPTALSAPQLEVLLNGLTKNLDLSVLEELTIEANPGDLDAD
                     KIAVLKNSAVNRVSLGVQTFDDKMLKKIGRSHLEKDIYENIDRLKLAGFDNISIDLIY
                     ALPGQTMEQVKENVAKAIGLDIPHMSLYSLILENHTVFMNRMRRGKLPLPKEELEAEM
                     FEYIIAELERAGFEHYEISNFSKPGFESRHNLMYWDNAEYYGIGAGASGYVNGVRYKN
                     HGPIRHYLSAVEEGNACITEDHLSQKEQMEEEMFLGLRKKSGVSMARFEEKFGQSFAG
                     LYGEIVRDLVQQGLMQIEGDHVRMTKRGLFLGDTVAERFILE"
     gene            10254..10991
                     /locus_tag="AC0DU4_001595"
     CDS             10254..10991
                     /locus_tag="AC0DU4_001595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA];
                     GO_process: GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-ACP thioesterase domain-containing protein"
                     /protein_id="HIN4237531.1"
                     /translation="MGLTYQMKMKIPFDMADMNGHIKLPDVILLSLQVSGMQSIELGV
                     SDKAILEDYNLVWIIAEYDIEVVRLPRFAEEITIETEALSYNRLFCYRRFTIYNEAGQ
                     ELIHMMATFVLMDRDSRKVHAVEPEIVAPYQSDFDKKLIRGPKYESLEEPISKDYHVR
                     FYDLDMNGHVNNSKYLDWIFEVMGADFLTHYIPKKINLKYVKEVRPGGVITSAVERTG
                     LESKHEITSDGVINAQAIITWQEIKKV"
     gene            11002..>11645
                     /locus_tag="AC0DU4_001596"
     CDS             11002..>11645
                     /locus_tag="AC0DU4_001596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01457 family HAD-type hydrolase"
                     /protein_id="HIN4237532.1"
                     /translation="MKYKGYLIDLDGTIYKGKDRIPAGETFVHELQKRDIPYLFVTNN
                     TTRTPESVKEMLAQNFNIDTPLSTVYTATLATIDYMNDLGLEKTVYVVGEAGLKEAIK
                     AAGYVEDKENPAYVVVGLDWQVDYEKFATATLAIQKGAHFIGTNPDLNIPTERGLLPG
                     AGSLITLLEVATRVKPVYIGKPNAIIMDKAVEHLGLEREELIMVGDNYLTDIRAG"
BASE COUNT         3625 a         2034 c         2616 g         3370 t
ORIGIN      
        1 accaagtttg gtgacggcgg tgcggatatt ctccctcttt accgcctcaa taaacgccaa
       61 ggaaaacagc tcttgcagaa acttggcgca gagccagccc tttatgaaaa aatcccaacg
      121 gcagacctag aagaagataa accaggccta gctgacgaag tcgcacttgg agtcacctat
      181 gcagagattg acgattacct agaaggcaaa acaatcagcc cagaagctca agcgaccatt
      241 gaaaactggt ggcacaaagg ccaacacaaa cgccacttac ccatcaccgt atttgatgac
      301 ttttgggagt aaaaacctcc attggaggtt tttaccctga gcctagaaat gagaaagtga
      361 gagaaggtcc gggggatctt gaaccccgag tttagaaata agaaaatgag gcagattcgg
      421 taactcgaag agttcgattt catcgtctta cccctgcaac gatgactagg tttgaaaaag
      481 cttgctagat cgcatttcaa accaggcagc gactgcgtca agaaattaga agacaaactc
      541 gttttctagc tgttactgag ttgagtcttt ttactacgag catagaaata aggaagtgag
      601 gtagcatcat gaaatctatc ggtacgcaaa tattacagac agaacgtttg attttaagaa
      661 gatttgtgga gagtgatgca gaagccatgt ttcaaaattg ggcttcatcc gctgagaatt
      721 tgacctatgt tacctgggat ccccatcctg atgtcgaaat cactcgaaac tcgattcgca
      781 attgggttgc ttcctatact aatctcaact attacaaatg ggccatttgt ctaaaagaaa
      841 acccagagca agtgatagga gatatcagca tcgttaagat agacgaggct gatttaagct
      901 gtgaaatcgg ctatgtgcta ggcaaggctt actggggaca tggtatgatg acagaggcct
      961 tgaaagctgt cttggacttt tgttttactc aagcaggttt tcaaaaggtc agagcacgtt
     1021 atgccagtct caacccagct tcaggtcgtg tcatggaaaa ggctggaatg tcctatctac
     1081 aaaccattgt taatggtgta gagagaaaag gctatcttgc ggatcttatt tattatggta
     1141 taagtaggga agaatgttga attctatttt ctgtttctat cgaagtcaac tatttattgt
     1201 aaatataata attagcattc caagtttatt tgaaacttta aaatagcata ttgattagta
     1261 caagacagat gttctagttc cttctttaat ctggtttagt attagttaaa aaatcgcttg
     1321 aagcttgtaa ctaagaggga gctaatcgac taggttctcc agccgaacag gtggtaatgt
     1381 actttttata gtgtaatcct agctgttgtt aaatttaaaa tagaatcctc tatcgagtta
     1441 gggaattaaa ttcaaccaat tttatttatg tttttctatc aaattatcta atattaaaat
     1501 agtctcattc tgatgagaaa actattctat ttatactgca tagttgtata aggaatgatg
     1561 aaagatgagt gaaagttatc aagttggaat gtttgtatct aaatatatta gcatgtattt
     1621 agataagatg tctgcaatcc tttatatatg agattgatta cgatatagtt aaagtgttag
     1681 ttcaataatc aatatatcat tctaagtcta ttttatatat aaagtatatt gtttaacgtt
     1741 tgatagaaaa gatgctatac tagaagtagg atgtaatggc aaaatctaat actaataagc
     1801 gctatgcaat acgtaaactc ggaaagattt ttggttctgc ggtaatcggg ctaactttat
     1861 ttttaggagg aatctgaata caagttttgt tcatgctgct gatgggattc aatatgtcag
     1921 agatgatact agagataaag aagagggaat agagtatgat gacgctgaca atggggatat
     1981 tattgtaaaa gtagcgacta aacctaaggt agtaaccaag aaaatttcaa gtacgcgaat
     2041 tcgttatgaa aaagatgaaa caaaagaccg tagtgaaaat cctgttacaa ttgatggaga
     2101 ggatggctat gtaactacga caaggaccta cgatgttaat ccagagactg gttatgttac
     2161 cgaacaggtt actgttgata gaaaagaagc cacggataca gttatcaaag ttccagctaa
     2221 aagcaaggtt gaagaagttc ttgttccatt tgctactaaa tatgaagcag acaatgacct
     2281 ttctgcagga caggagcaag agattactct aggaaagaat gggaaaacag ttacaacgat
     2341 aacttataat gtagatggaa agagtggaca agtaactgag agtactttaa gtcaaaaaaa
     2401 aagactctca aacaagagtt gttaaaaaag gaaccaagcc ccaagttctt gtccaagaaa
     2461 ttccaatcga aacaaaatat ctcgatggcc caactcttga taaaagtcaa gaagtagaag
     2521 aagtaggaga aattggtaaa ttactcttac tacaatctat actgtagatg aacgtgatgg
     2581 aacaattgaa gaaactactt ctcgtcaaat tactaaagag atggtaaaaa gacgtataag
     2641 gagagggacg agagaacctg aaaaagttgt tgttcctgag caatcatcta ttccttcgta
     2701 tcctgtatct gttacatcta accaaggaac agatgtagca gtagaaccag ctaaagcagt
     2761 tgctccaaca acagactgga aacaagaaaa tggtatgtgg tatttttata atactgatgg
     2821 ttccatggca acaggttggg tacaagttaa tggttcatgg tactacctca acagcaacgg
     2881 ttctatgaaa gtcaatcaat ggttccaagt tggtggtaaa tggtattatg taaatgcatc
     2941 gggtgagtta gcggtcaata caagtataga tggctataga gtcaatgata atggtgaatg
     3001 ggtgcgttaa cagattcctc cctgcgacaa aattgataat agtatgtctg aatatataat
     3061 tatatataaa aagctataga taaggtcatc ttatagcgac tataaaaaag tgaacaagcc
     3121 tagtcttctg tacattagaa ttcagatttg ttcacttttt gtttaatact caatgaaaat
     3181 caaagagcaa actagaaaac tagtcgcagg ttgctcaaag tactgctttg aggttgtaga
     3241 tagaactgac gaagtcagtc acatatataa tccaaggtga cgttgacgcg gtttgaagag
     3301 atttttgaag agtataagtc tttgattttg agactaagga gagtcagggt caaagtagtg
     3361 aatgattctg aaataactca taatagtctc ttgagaggac agataagagt aacaaatatg
     3421 gtgctactca tgtgtcttgc attttgattt acaaacagcg aagaaaatat aggaagctga
     3481 aataaaatat agatgaatca atttggagag tcaacgcaat ctatggcaat attttcgaag
     3541 ctagggggaa gcattttaat ttcaatgtac taggcctctt ctacagctag ctagagtttc
     3601 aattgtagat gttctttgaa ataatatctt agcgatttat tggtattaga agatttagag
     3661 aaattctttc tcaataaata aacatggcgt caccaaaact gaagaagcgg tagtgttctt
     3721 ggatggcatg gtggtaggca tctaagacta attcacggcc tgcaaaggca gaaaccaaca
     3781 tgaccagagt tgattttggc aggtggaagt tggttgagaa ggcatccacg accttccact
     3841 catacccagg tttgataaag atattggtcc aaccagaatc tgcttggatt tgcccatcaa
     3901 acttggaacc aatagtttcc aaggtgcgga tagaagtggt tccgacagcg atgacacgac
     3961 caccattttc tttgacagag cgaagggtgg cagcagcttc ctcagaaagt tgatagaact
     4021 ctgagtgcat ttcgtgttcg tccagattat ccacagaaac aggtctaaag gttccgagtc
     4081 cgacatggag agtcagatag actagatgaa cacccttagc ttggatttct gccagcagtt
     4141 ctttggtgaa gtgaagacca gcagtcggtg ctgcagcaga gccgctttcc ttggcgtaga
     4201 cggtttgata acgttcacgg tcatctaatt tttcgtggat ataaggtggc agaggcattt
     4261 ctcccagact ttccaagact tctaggaaaa ttccttggta ttcaaagcgg acaatgcgtc
     4321 ccccgtgggt caattcttct gtaacgacag cgctgaggcg gccatcacca aagctgatac
     4381 gagtaccgac cttgaggcgt ttggcaggtt tagccagaac ttcccactcg tctccactag
     4441 tgttcttaag gaggagaagt tccacatgac ctcctgtctc cactttttga ccatagaggc
     4501 gggcagggag aactcgggtg tcgttcatga caagggcatc accaggttcc agcatatcaa
     4561 taatagagtg gaagtgttta tcttgcattt ctcctgtctc acggttgacg atgaggagtt
     4621 tggaggcatc acgtttttca aggggcgttt gggcaatcaa ttcctctggc aagtggaaat
     4681 caaaatcagc tgtattcata tatttgttca ttctttctaa gttctaatcc tatccattat
     4741 aacacgtttc aagtttggac gctctttttt tagaaattaa atcgttttca cttgacaaaa
     4801 attggtctat accatataat aaatatagac agaaatggag gatgaaaaga tgaaagttat
     4861 taaagttgaa aaccaagttc aaggtggaaa agttgctttt gagattttga aggaaaaatt
     4921 ggctaatgga gctcaaactc taggacttgc gacaggaagt agcccacttg aattttacaa
     4981 ggaaattgtt gagagtgacc ttgatttttc aaatctaacc agtgtcaacc ttgatgagta
     5041 tgtgggcctt gatggggaca atccacagtc ttatcgttac ttcatgcaag aaaacttgtt
     5101 caaccaaaaa ccatttaaag aaagtttctt gcctcgtggt gttaaggaca atgctgaagc
     5161 tgaagttgaa cgctacaacc aaattttggc tgaccatcca gttgacctcc aaatcttggg
     5221 aatcggtcgc aatgggcata tcggctttaa tgagcctggt actccatttg acagtcaaac
     5281 gcatctagta gaacttgacc agtctactat cgaagccaat gcacgcttct ttgccaagat
     5341 tgaagacgtc ccaacccaag ctatttcaat ggggattaaa aacattttgg atgccaagtc
     5401 tattattctt tttgcttacg gtgagtcgaa agcagaagcc attgccggaa cagtatctgg
     5461 cccagtgact gagaacctac ctgcaagtag cctccaaaat caccctgatg taaccatcat
     5521 cgcagatgct gaagcgctta gcttactcga aaaataaaaa gtataagaac cgcttgctct
     5581 ttggagtgag tggttttaga catataaaac ttcaacttaa ctttaggagg acacatgaat
     5641 aaagaagaat ttttaaaaat aaaagaagca tataagagtg ctagaacgga agaaagaaaa
     5701 agtataatag gcttcattac aaaaaagaaa gataaggagg ggaattttct ttttactaag
     5761 tcaaaagata aaccatatac cacaagaaat caatattcag gaggcggagg aaataaaaag
     5821 tacacctcgg gtagtagatt atctaggcca tatgatttat caaatcacat gtggattgat
     5881 ttgtcatata aaggaaatga catcttaatc tctttacagt cttttgatat tgatccaaat
     5941 agtaaagaac ttcacgtctt atatgataga ataggcatct tatttgaaca atctaaaaaa
     6001 attccaattt ttaaagattg ctatacaata actaaagtca gtgatgcttt tcttaaaatg
     6061 gaaacaacaa actgggaatt acctttatct aaagcagata tggaagagat ggtgaactat
     6121 attattaatc attatgaaga ataaaaaact tagtttcctc ttgacaatta ttccttttac
     6181 gtgtagaatg aaatagatat tgaacttgaa gggagtgaaa aaaatgtcta aaacagtagt
     6241 acgtaagaat gaatctcttg acgacgcact tcgccgtttc aaacgtgcgg ttactaaagc
     6301 tggtactctt caagaaacac gcaaacgtga attctatgaa aaaccttctg taaaacgtaa
     6361 acgtaaatca gaagtagctc gtaaacgtaa aaaattctaa ttgaaatgaa aggctagaga
     6421 aatctagtcc tttttctttt aaataaatac tccaaagcct gcaaaaatct gaaacttcct
     6481 cctacaattt gatataatag agagaagaac tcatttgaag gaggaaatga tgtcggtttt
     6541 agtaaaagaa gtgattgaaa agcttagact agacattgtc tatggtgaac cagaattgct
     6601 tgaaaaggaa atcaatatag cggatattac gcgacctggt cttgaaatga caggctattt
     6661 tgactactat acaccagagc ggattcaact tttggggatg aaggagtggt cttatctgat
     6721 cagcatgcct tccaacagcc gttatgaagt tttgaaaaaa atgtttctac ctgagacacc
     6781 agcagtcatt gttgcccgtg gtttggtggt tccagaggag atgttaaagg ctgctagaga
     6841 atgtaagatt gctattttaa ccagccgtgc agctaccagt cgtttatctg gagagttatc
     6901 tagctatctg gattctcgtt tggcagaacg taccagtgtg cacggtgtct tgatggatat
     6961 ttatgggatg ggcgtcttga ttcagggaga tagtggaatt ggtaagagtg agacaggtct
     7021 tgagcttgtc aaacgtggtc accgtttggt agccgatgac cgtgtcgata tctttgccaa
     7081 ggatgagatt actctctggg gtgaaccagc tgaaattttg aaacacttga ttgaaattcg
     7141 tggggttggt attatcgatg ttatgagtct ctacggtgcg agtgctgtca aggattcttc
     7201 acaggttcag cttgctgtct atttggaaaa ttacgatacg cataagacct ttgatcgtct
     7261 tggaaacaat gcagaggaac ttgaagtttc tggcgtagcc attcctcgta ttcgtattcc
     7321 agttaaaaca ggtcgtaata tctctgttgt gattgaggca gctgccatga attatcgtgc
     7381 caaggaaatg ggctttgatg cgacccgttt gttcgacgaa cgactgacaa gtctcatcgc
     7441 tcgaaatgag gtgcaaaatg cttgatccaa ttgctattca actaggaccc ctagccattc
     7501 gttggtatgc cttatgtatt gtgacaggct tgattcttgc ggtttatttg accatgaaag
     7561 aagcacctag aaagaagatc ataccagacg atattttaga ttttatctta gtagcctttc
     7621 ccttggctat tttaggagct cgtctctact atgttatttt ccgatttgat tactatagtc
     7681 agaatttagg agagattttt gccatttgga atggtggttt ggccatttac ggtggtttga
     7741 taactggggc tcttgtgctc tatatctttg ctgaccgtaa actcatcaat acttgggatt
     7801 ttctagatat tgcggcgcct agcgttatga ttgctcaaag tttggggcgt tggggtaatt
     7861 tctttaacca agaagcttat ggtgcaacag tggataatct ggattatcta cctggcttta
     7921 tccgtgacca gatgtatatt gaggggagct accgtcaacc gactttcctt tatgagtctc
     7981 tatggaatct gcttggcttt gccttgattc tgatttttag acggaaatgg aagagtctca
     8041 gacgaggtca tatcacggcc ttttacttga tttggtatgg tttcggtcgt atggtcatcg
     8101 aaggtatgcg aacagatagt ctcatgttct tcggacttcg agtgtcccaa tggctgtcag
     8161 ttgtccttat cggtctcggt ataatgatcg ttatttatca aaatcgaaag aaggcccctt
     8221 actatattac agaggaggaa aactaaatgt tagaagttgc atatattctt gttgccttag
     8281 ctttgattgt ctttttggtc tatctgatca ttactgtaca aaagcttggt cgtgtcatcg
     8341 atgaaacaga aaagacgatt aaaaccttga cttcagatgt ggatgtgacc ttgcatcaca
     8401 ccaatgagtt gttggctaag gtcaatgtct tggcagatga tatcaatgtc aaggtggcta
     8461 cgattgatcc actcttcagt gctgttgcag atttatctct atctgtttca gacctcaatg
     8521 accatgcgcg tgtcttgagc aagaaagctt catcagctgg ttcaaaaaca ctcaagactg
     8581 gtgcaagtct gtcagctctt cgtcttgcaa gtaaattttt caaaaaataa aaaaggagaa
     8641 tccttatggg taaattatcc tcaatccttt taggaacggt ttcaggtgca gctcttgcct
     8701 tgtttttaac aagtgataag ggcaaacaag tttgcagtca ggctcaagat tttctagatg
     8761 atttgagaga agatccggag tatgccaagg agcaagtctg tgaaaaactg acagaagtta
     8821 aggagcaggc tacagatttt gttctgaaaa caaaagaaca ggttgagtca ggtgaaatca
     8881 ctgtggacag tatacttgct caagctaaat cctatgcttt tcaagcgaca gaagcatcaa
     8941 aaaatcaatt aaataatctc aaggaacaat ggcaagaaaa agccgaagct cttgatgact
     9001 cagaagagat tgtgattcat ataacagaag aataaaccat caccatctcc ggacggacta
     9061 tgtatctggg gatggtgatt tttatctgga atctagtctt tgtggtataa taattactat
     9121 gcagaaaaaa ccaacgtcag cctatgtgca catcccattt tgtacccaga tttgttatta
     9181 ttgtgatttt tcaaaggtct tcatcaaaaa tcagccagtc gacagctatt tagagcatct
     9241 gctggaagag tttcgttctt atgatattga aaagttgtca accctttata tcggtggtgg
     9301 aacaccgaca gccctgtcgg ctccgcaact ggaggtgtta ctgaatggct tgactaaaaa
     9361 cttggatttg tctgtcttgg aagagttgac cattgaagcc aatccaggcg atttggatgc
     9421 ggataagata gctgttttga aaaattcggc tgtcaatcgt gtttcgctag gtgtccagac
     9481 ctttgatgat aagatgttga aaaagattgg gcgcagtcat ttggagaagg atatttatga
     9541 aaatatcgat cgcctgaaac tggctggttt tgacaacatc tccattgatt tgatttatgc
     9601 tctgcctggt cagaccatgg agcaagtaaa ggaaaatgtg gctaaagcca ttggattgga
     9661 tattccccac atgagtttgt atagtttgat tttagaaaac catacggtct ttatgaaccg
     9721 gatgcgacgt gggaaattgc ctctgcctaa ggaggaacta gaagcggaga tgtttgagta
     9781 catcattgca gagctggagc gagcgggttt tgagcattat gagatttcta atttctccaa
     9841 acccggtttt gaaagtcgtc ataatctcat gtactgggac aatgctgaat actatggtat
     9901 tggtgcaggg gcatctggtt atgtcaatgg agtacgctat aaaaatcatg gtcccattcg
     9961 tcattatctc agtgcggttg aggaaggcaa tgcttgtatt acagaagatc acctgagtca
    10021 aaaggagcaa atggaagaag aaatgttctt gggactccgc aagaaatccg gggtttccat
    10081 ggcgcgattt gaggaaaaat ttggacagtc ttttgctgga ctttatggag aaattgtcag
    10141 agatttggtt caacaaggcc tcatgcagat tgagggtgac cacgttcgca tgacaaagag
    10201 aggtctcttt ttgggagata ctgtagcaga acgatttatt ttggagtagg atcatgggct
    10261 taacttatca aatgaaaatg aaaattcctt ttgatatggc tgatatgaac ggtcatatca
    10321 aacttccaga tgtgattttg ctgtcactgc aagtttcagg gatgcaatcg attgaactgg
    10381 gagttagtga taaggccatt ttggaagact ataatctggt ctggattatc gcagaatatg
    10441 atattgaggt ggttcgtttg cctcgttttg cggaagaaat taccatcgaa acggaagcct
    10501 tgagctacaa tcgacttttt tgctaccgtc gctttactat ttataatgaa gcggggcagg
    10561 agctcatcca tatgatggcg acctttgttc tcatggaccg cgacagtcga aaagtccatg
    10621 ctgttgaacc tgagattgtg gctccttacc agtctgattt tgataaaaaa cttatccgtg
    10681 gaccgaagta tgaatccttg gaagagccga tcagcaagga ttaccatgtt cgtttttacg
    10741 acttggatat gaatggtcat gtcaataaca gtaaatactt ggactggatt tttgaggtca
    10801 tgggagcgga ttttttgacc cactatattc ccaagaaaat caacctcaag tatgtcaagg
    10861 aagttcgacc aggtggggtg attacatcgg ctgttgaacg gactggactg gaaagcaagc
    10921 atgaaattac aagtgatggg gttatcaatg cccaagcaat cattacttgg caagaaataa
    10981 aaaaggttta gggagaaata gatgaaatat aaaggctatt taatcgattt agacggaacc
    11041 atttataagg ggaaagaccg aatccctgct ggagagactt ttgttcatga attgcaaaag
    11101 cgggacattc cctatctctt tgtaaccaac aatacaaccc gcactccaga gagtgttaag
    11161 gagatgttgg ctcagaattt taatatcgat acgcctctat cgactgtcta cacagcgact
    11221 ttggcaacca tcgactatat gaatgatttg gggcttgaaa agaccgtcta tgtcgtcgga
    11281 gaagcaggac tcaaggaagc catcaaggcg gctggttatg tggaagacaa ggaaaaccct
    11341 gcctacgtgg tagttggtct ggattggcaa gtcgactatg aaaaatttgc cacagcaact
    11401 cttgctattc aaaagggtgc ccattttatc ggaaccaatc ctgacctcaa catcccgacg
    11461 gaacgtggtc ttttgccagg tgctggctca ctgattacgc tgcttgaagt agcgacacga
    11521 gtgaagccgg tttatatcgg aaaaccaaat gccatcatta tggacaaggc ggttgagcac
    11581 ttaggtttgg aacgtgaaga gttaatcatg gttggggaca attatttgac tgatatccgg
    11641 gctgg
//
LOCUS       DBMVGT010000055        11297 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.055, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000055 DBMVGT010000000
VERSION     DBMVGT010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 11297)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11297)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11297
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.055"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..421)
                     /locus_tag="AC0DU4_001597"
                     /pseudo
     CDS             complement(1..421)
                     /locus_tag="AC0DU4_001597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(624..1028)
                     /locus_tag="AC0DU4_001598"
     CDS             complement(624..1028)
                     /locus_tag="AC0DU4_001598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000846948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein"
                     /protein_id="HIN4237533.1"
                     /translation="MKTFLAKKRNIFLARLFLGQLPLLVSTYLFLSRQFLNFSVVFQF
                     LLVVINLASILVTVYLTREMRIREFEDDDLVSPRTNQLMFIGLTGFMSIICLYRGITA
                     GESYQQIIAYIGAVLCLIIMLLLMWGLKYYKK"
     gene            complement(1025..1189)
                     /locus_tag="AC0DU4_001599"
     CDS             complement(1025..1189)
                     /locus_tag="AC0DU4_001599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237534.1"
                     /translation="MKKKILIIFVLYLIMSIFLYPLRESAWYQLFYTIAYVIAVMIYF
                     AINKKKGEKK"
     gene            complement(1486..1605)
                     /locus_tag="AC0DU4_001600"
     CDS             complement(1486..1605)
                     /locus_tag="AC0DU4_001600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="HIN4237535.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDNLIRKIFSKFPKKDTDSTP"
     gene            complement(1608..1766)
                     /locus_tag="AC0DU4_001601"
     CDS             complement(1608..1766)
                     /locus_tag="AC0DU4_001601"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237536.1"
                     /translation="MQLGDFAKAGVGGAAARGLQLGIKTGTWQGAATGAAGGAILGGV
                     AYAATCWW"
     gene            complement(1703..1837)
                     /locus_tag="AC0DU4_001602"
     CDS             complement(1703..1837)
                     /locus_tag="AC0DU4_001602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin class II family protein"
                     /protein_id="HIN4237537.1"
                     /translation="MDTKMMSQFSVMDTEMLACVEGGGCNWEILPKQVLEEQQQEVFN
                     "
     gene            complement(1906..2175)
                     /gene="blpJ"
                     /locus_tag="AC0DU4_001603"
     CDS             complement(1906..2175)
                     /gene="blpJ"
                     /locus_tag="AC0DU4_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093248.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpJ"
                     /protein_id="HIN4237538.1"
                     /translation="MNTKMLSQLEVMDTEMLAKVEGGYSSTDCQNALITGVTTGIITG
                     GTGAGLATLGVAGLAGAFVGAHIGAIGSGLTCLGGMVGDKLGLSW"
     gene            complement(2641..2838)
                     /gene="blpI"
                     /locus_tag="AC0DU4_001604"
     CDS             complement(2641..2838)
                     /gene="blpI"
                     /locus_tag="AC0DU4_001604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpI"
                     /protein_id="HIN4237539.1"
                     /translation="MNTKMMEQFSVMDNEELEIVSGGRGNLGSAIGGCIGAVLLAAAT
                     GPITGGAATLICVGSGIMSSL"
     gene            3119..5272
                     /gene="blpA"
                     /locus_tag="AC0DU4_001605"
     CDS             3119..5272
                     /gene="blpA"
                     /locus_tag="AC0DU4_001605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_125458604.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter BlpA"
                     /protein_id="HIN4237540.1"
                     /translation="MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKT
                     NKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDVPYPFIVHVNKEGKLQHYYVVYQ
                     TKKDYLVIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
                     IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYIL
                     QQVMSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTGEIISRFTDANSII
                     DALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMFIIFSFMKPFEKMNH
                     DVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQT
                     SLKQGTKLVLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQS
                     AKVANNRLNEVYLVESEFQVQENPVHSHFLMGDIEFDDLSYKYGFGRDTLTDINLTIK
                     QGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHINYLPQQ
                     AYIFNGSILENLTLGGNHMISQEDILKACEVAEIRQDIERMPMGYQTQLSDGAGLSGG
                     QKQRIALARALLTKSPVLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAE
                     RTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK"
     gene            5283..6644
                     /locus_tag="AC0DU4_001606"
     CDS             5283..6644
                     /locus_tag="AC0DU4_001606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="HIN4237541.1"
                     /translation="MNPNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKE
                     ITVTSQGEIAPTSIISSIQSTSDNPILANHLVANQVVEKGDLLIKYSETMEESQKTAL
                     ATQLQRLEKQKEGLGILKQSLEKATDLFSGEDEFGYHNTFMNFTKQSHDIELGITKTN
                     TEVSNQANLANSSSSAIEQEITKVQQQIGEYQELRDAIINNRARLPTSNPHQSILNRY
                     LVASQGQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVL
                     RTQFLQTASQQQLTVENQLTELKVQLDQATQRLENNTLTAPSKGIVHLNSEFEGKNRI
                     PTGTEIAQIFPIITDTREVLITYYVASDYLPLLDKGQTVRLKLEKIGNHGITIIGQLQ
                     TIDQTPTRTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTAKKTYFDYFKDKILT
                     HSD"
     gene            6701..6856
                     /gene="blpC"
                     /locus_tag="AC0DU4_001607"
     CDS             6701..6856
                     /gene="blpC"
                     /locus_tag="AC0DU4_001607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="HIN4237542.1"
                     /translation="MDKKQNLTSFQELTTTELNQITGGGLWEDILYSLNIIKHNNTKG
                     LHHPIQL"
     gene            complement(6901..8241)
                     /locus_tag="AC0DU4_001608"
     CDS             complement(6901..8241)
                     /locus_tag="AC0DU4_001608"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000275284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HIN4237543.1"
                     /translation="MNVAWILLYTLVTHGLKIVIFFKVDGIGLTFERIFKAFLLKILL
                     AFVFVMIGYMVGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRG
                     VSYFVLPFLGQEQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRREILDTGFQK
                     SLTKINWIMGAYYLVIQSLSYFEYEQGIQSTTVRHLILVFYLLFFMGVIKKLDTYLKD
                     KLHDRLDQEQVLRYRDIERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIK
                     EVYDLVLRDSSQKLQDNKYDLGRLVNVRDRALKSLLAGKFIKAREKDIVFNVEVPEEI
                     QVEGMRLLDFLTIVSILCDNAIEASAEAGQPHVSIAFLKSGAQETFIIENSIKEEGID
                     ISEIFSFGVSSKGEERGVGLYTVMKIVESYPNASLNTTCQDQVFRQVLTMIPTE"
     gene            complement(8255..8992)
                     /locus_tag="AC0DU4_001609"
     CDS             complement(8255..8992)
                     /locus_tag="AC0DU4_001609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001219153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HIN4237544.1"
                     /translation="MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLL
                     AEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQDPYALIVFVTTHSEFMPLSFRYQ
                     VSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
                     LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKL
                     LFFPNGGSCLIARYKVREVSEAINNLH"
     gene            complement(8997..9335)
                     /locus_tag="AC0DU4_001610"
     CDS             complement(8997..9335)
                     /locus_tag="AC0DU4_001610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="HIN4237545.1"
                     /translation="MKHMIIQTQKTVYKVNIDDIYYIQTHPTKAHTVQIVTEKASFNM
                     LQNLSNLENQCGETLMRCHRNCLVNLDKLKSIDFQERILFLGEEGQYAVKYARRRYRE
                     IRQKWLKEGE"
     gene            9611..9940
                     /locus_tag="AC0DU4_001611"
     CDS             9611..9940
                     /locus_tag="AC0DU4_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
                     /protein_id="HIN4237546.1"
                     /translation="MTDTDPIKRAHTLITDLNKAYQACKQASADDVRFQEQLNSILGF
                     LAKAETVDNRFLIELEKFYQTSSLLMGLSALDPDAPTRAAWRAYDRFHFDQVKTKLIL
                     NENQRAN"
     gene            complement(10108..11157)
                     /locus_tag="AC0DU4_001612"
     CDS             complement(10108..11157)
                     /locus_tag="AC0DU4_001612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237547.1"
                     /translation="MKDLFLKRKQAFRKECLGYLRYVLNDHFVLFLLVLLGFLAYQYS
                     QLLQHFPENHWPILLFVGITSVLLLLWGGIATYMEAPDKLFLLVGEEEIKLHLKRQTG
                     ISLVFWLFVQTLFLLLFAPLFLAMGYGLPVFLLYVLLLGVGKYFHFRQKASKFFTETG
                     LDWDYVISQESKRKQVLLRFFALFTQVKGISNSVKRRAYLDFILKAVQKVPGKIWQNL
                     YLRSYLRNGDLFALSLRLLLLSVLAQVFIEQAWIATAVVVLFNYLLLFQLLALYHAFD
                     YQYLTQLFPLDKGQKEKGLQEVVRGLTSFVLLVELVVGLITFQEKLALLALLGAGLVL
                     LVLYLPYQVKRQMQD"
     gene            complement(11154..>11297)
                     /locus_tag="AC0DU4_001613"
     CDS             complement(11154..>11297)
                     /locus_tag="AC0DU4_001613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237548.1"
                     /translation="KMCDAFVILHKGEVRAKGNLLQLREAFDMPEASLNDIYLALTKE
                     EDL"
BASE COUNT         3765 a         2351 c         1837 g         3344 t
ORIGIN      
        1 cttcatagcg tgaaatttct ttttaccaga ataattcgct aattcttttt ttagggcgat
       61 tgatttttac ttccgtcgca tcaatcatta ccgtgtcctc agaactgaga ggagttcttg
      121 aaatcgtaac accactttga acaagagtta cttcaaccca ttggctccga cggagtaagt
      181 tgctttcgtg aacaccaaaa tcagccgcaa tttcttcata agtgcggtat tctcgcacat
      241 attgaagagt ggccataaga aggtcttcta ggcttaattt aggttttcgt ccaccttttg
      301 cgtgtttaag ttgataagct gtttttaata cagctaacat ctcttcaaaa gtggtacgct
      361 gaacaccaac aagacgctta aatcgtgcat cggttagttg tttacttgct tcataattca
      421 tagaactata gtaaaatgaa ataagaacag gataaatcga tcaggacagt caaatcgatt
      481 tctaacaatg ttttagaaat agaggcgtac tattctagtt tcaatctact atactatacc
      541 atattttgtt tcgcagggaa tctattataa aagggtaagt attgcaaaaa cacttaccct
      601 tttcttttat acttcattaa gctctacttt ttataatact tcaagcccca catgagcaga
      661 agcatgatga ttaagcagag aacagcgcca atataagcga ttatttgttg gtaggattct
      721 cctgctgtga tacctctata caaacaaata atagacataa aacctgtcaa gccgatgaac
      781 ataagttgat tggttctagg actaaccaaa tcatcatctt caaactctct tatcctcatt
      841 tccctagtga gataaacagt aaccaaaata gaagccaagt taataactac taaaagaaat
      901 tggaaaacta cggaaaaatt taaaaactga cgagatagaa atagataagt agaaacaagc
      961 aagggcaact gacctaagaa caatctcgca aggaagatgt tccgtttttt agcaagaaaa
     1021 gttttcattt cttttctcct ttctttttat tgatagcaaa atagatcata actgcaatca
     1081 cataggctat ggtataaaat agctgatacc aagcactctc cctaagcgga tatagaaaga
     1141 tggacatgat tagatacaga acgaaaataa tcagtatttt tttcttcata agatttcctc
     1201 ctaaatgtgc gatttatctt agttgagcaa gaacatttac actgctagta tagcacttat
     1261 tttgaccttg gatcactcaa atcataaatg gtcatcaaaa cctcttgaat tgtaaaaatt
     1321 aaaaaagcaa gcatgaaaaa catactttcc tctttatatt gtattgatac caacttgttt
     1381 gtagactttt catcctgcta tcacatatca ttttgacagg cgaaacaaaa ttaaagaaac
     1441 tcccctgtaa attaagctag caaatacagg ggagaaattt attttttagg gggtactatc
     1501 tgtatccttt ttgggaaatt ttgaaaatat ttttctaatt aaattatcca tataaggacc
     1561 aaatatacca actactaaac caataataaa acttttaaaa tccataatta ccaccaacat
     1621 gttgctgcat aggctacacc tccaagtata gctccacccg cagcaccagt tgctgcacct
     1681 tgccatgttc ctgttttaat gcctagttga agacctcttg ctgctgctcc tccaacacct
     1741 gctttggcaa aatctcccaa ttgcatccgc caccttcaac gcaagcaagc atttcagtat
     1801 ccataacaga aaattgtgac atcatttttg tatccatgac aaatactcct tttttaaaaa
     1861 actaaaataa atcagaatag aatcctcata attttactat aagtcttacc aacttagtcc
     1921 caatttatca ccaaccatac ctcctaagca tgttaatcca ctcccaattg caccaatgtg
     1981 tgctccaaca aatgcaccag caagtccagc tactcctaaa gtggccaaac ctgctccagt
     2041 tccaccagtt ataattcccg tagtgactcc tgtaatcagt gcattttgac aatcagtgga
     2101 gctatacccc ccttcaactt tcgcaagcat ttcagtatcc ataacctcta actgtgacaa
     2161 catttttgta ttcatgatga atacctcctt tttattttca atttgttacc aaagtcttaa
     2221 attcaataaa caaatagatt ttttatagta tctttttgat tttcttaaaa aagtatatac
     2281 gtctactatc ttcttaaagg tagcagtacc tatttttagt ctaagatttc aataatcttg
     2341 agtatctaaa atatcttaat ttcgttattc tccttgcaat aaaaagtttt actatactat
     2401 ttattaactt gcagaaagca aaaaatatta gtaaataata gtttatagtt aagtttttta
     2461 ttcctaccaa tccatcaact aagtaaagca tcaacgatta cataaacgat tgataatata
     2521 attaaaattt tgctaactat cttattctca tcattcttag ataactttga tattttgtaa
     2581 gtaagtaaat aagacagtaa attaatagcg ataataatac tatatttaag aatcataatc
     2641 ttacaaagag gacataattc ctgaacctac acaaataagt gttgctgctc ccccagttat
     2701 cggaccagtc gcagcagcta atagtactgc tccaatacaa ccaccgattg cagatcctaa
     2761 attgcctctt cctccactaa ctatttcgag ttcttcatta tccataacag aaaattgttc
     2821 catcattttt gtattcatga caaatactcc ttttttattt ttaatttttg tcttgttgca
     2881 actttgacaa gtttagtata tcattatttt ttaatttttt tcatccaaat cttgaattgc
     2941 catcgaaacg tcttgaatta gcttttttat ttcaagccac ctctaaatgt ttaaaaaaaa
     3001 taatttctaa tcactttttt accattcagg aagttttaat gactattcaa catttcataa
     3061 aatatgaact tagttttatg gcataatata cctatccact atatgaaagg aattgccaat
     3121 gacttcttat aaacgtacat ttgttcctca aatagatgcg agagactgtg gtgtcgctgc
     3181 cttagcctcg attgctaaat tctatggttc agatttttct ctagctcact tgagagaact
     3241 tgcaaagacc aataaagaag ggacgactgc tcttggcatt gtaaaagccg ctgatgaaat
     3301 gggctttgaa acaaggcctg ttcaagcaga taaaactctc tttgacatga gtgatgtccc
     3361 ctatccattt atcgttcacg ttaacaaaga aggaaaactc caacattact atgttgtcta
     3421 tcaaacaaag aaagactatc tggttattgg tgatcctgac ccttctgtaa aaatcactaa
     3481 aatgtcaaaa gaacgctttt tctctgaatg gactggagta gctatttttc tagctcccaa
     3541 acccagctat caaccccata aagataaaaa gaatggtcta ctaagcttcc ttcctctgat
     3601 tttcaaacaa aaatctctca ttgcttacat tgttctctca agcttattgg tcactattat
     3661 caatataggt ggttcttatt atctccaagg aatcttagat gaatacatcc caaatcagat
     3721 gaaatcaact ttaggaatca tctcagttgg tctggttatc acctatatcc tccaacaagt
     3781 catgagcttc tccagagatt atctcctaac cgttctgagc cagagattaa gcattgatgt
     3841 gattttatcc tatattcgcc atatttttga acttcccatg tctttctttg cgacacgtcg
     3901 tacaggagaa atcatttcac ggttcacaga tgctaactct attatagatg ccttggcttc
     3961 taccattctt tctcttttcc tggatgtttc tattctgatt cttgtagggg gcgtcttact
     4021 ggcacaaaac cctaatctct tccttctttc tcttatttct attcctatat acatgttcat
     4081 catcttttct tttatgaagc ctttcgaaaa aatgaaccat gatgtcatgc aaagtaattc
     4141 tatggttagc tctgccatta tcgaagatat caacgggatt gaaactataa agtcgctcac
     4201 gagtgaagaa aatcgctatc aaaatataga cagcgaattt gtagattatt tggaaaaatc
     4261 ctttaagctc agtaaatatt ctattttaca aacaagttta aagcagggaa caaaattagt
     4321 tctgaatatc cttatcctat ggtttggcgc tcaattagtc atgtcgagta aaatttctat
     4381 cggtcagctg attaccttta acacactttt ttcttacttt acaactccta tggaaaatat
     4441 tatcaacctc caaaccaaac tccaatctgc gaaggtcgct aataaccgtt tgaacgaagt
     4501 ctatctagtc gaatctgaat ttcaagttca agaaaaccct gttcattcac attttttgat
     4561 gggcgatatt gaatttgatg acctttctta taagtatggt tttggacgag ataccttaac
     4621 agatattaat ctcacgatta aacaaggaga taaggttagc ctagttggag ttagtggttc
     4681 tggtaaaaca actttagcca aaatgattgt caatttcttt gaaccctaca aagggcatat
     4741 ttccatcaat catcaggata ttaaaaacat tgataaaaaa gtcttgcgcc gtcatattaa
     4801 ttacctaccc caacaagcct atatctttaa tggctctatt ttggaaaact taaccttggg
     4861 cggtaatcat atgattagtc aagaagatat tctaaaagct tgtgaagtag ctgaaatccg
     4921 tcaagacatt gaaagaatgc ctatgggcta tcaaactcag ctctctgatg gagctggtct
     4981 atcaggagga cagaagcaac gaatcgctct cgctcgtgct cttttaacta aatctcctgt
     5041 tttaatacta gatgaagcta ctagcggtct tgatgtcttg actgagaaaa aagttataga
     5101 taatcttatg tccctaactg ataaaaccat tctctttgta gcccatcgtc tcagtatagc
     5161 cgaacgaacc aaccgtgtca ttgttcttga ccaggggaaa atcattgaag ttggtagcca
     5221 ccaagagtta atgcaggcgc aaggtttcta ccatcatcta ttcaataaat aaggagaatg
     5281 tcatgaatcc taatcttttt agaagcgtcg agttttatca gagacgttac cataactatg
     5341 cgacagtgtt aattatacct ctttcattac tatttacttt catcttgatt ttctcccttg
     5401 ttgccacaaa agaaattact gtcacttccc aaggagaaat cgcccctaca agtatcattt
     5461 catctattca gtcaaccagt gataatccta tccttgctaa tcatttagtg gcaaatcaag
     5521 tagttgaaaa aggggactta ctcatcaaat actctgaaac aatggaagaa agtcagaaaa
     5581 ctgccttagc aactcaatta caaagacttg agaagcaaaa agaaggactt ggaattttga
     5641 aacaaagctt agaaaaagcg actgatcttt tttctggcga ggatgaattt ggctaccata
     5701 atacctttat gaattttact aaacaatccc atgatattga actgggtatc acaaagacta
     5761 acactgaggt ttcaaatcaa gctaatcttg ccaatagcag ttcatcagct attgaacaag
     5821 aaattacaaa agttcaacaa caaattggag aatatcaaga gctgagagat gctatcataa
     5881 ataacagagc acgcttacca actagcaatc cacaccagtc aattttgaat cgttatcttg
     5941 tagcctcaca aggacaaaca caaggaacgg cagaggagcc atttttatct caaattaatc
     6001 aaagtattgc aggtcttgaa tcatctatcg caagcctcaa aattcagcaa gctggtatcg
     6061 gaagtgtagc aacttatgat aatagtttag caaccaaaat tgaagtactc cgcactcaat
     6121 ttttacaaac agcttctcag caacaactaa ccgtggagaa ccaattaaca gaattaaaag
     6181 tacaactaga tcaagcgaca cagcgcttag aaaacaatac cttaaccgct ccaagtaaag
     6241 gtatcgttca tctgaacagc gaatttgaag gtaaaaatag aattccaact ggtacagaaa
     6301 ttgctcaaat attccctatc atcacagata caagagaagt actaatcact tactacgtag
     6361 cttctgacta tctacctcta ctagataaag gacaaactgt aagattaaaa ctggagaaga
     6421 ttggaaatca cggcattacc atcatcggcc aacttcagac aattgatcaa actcctacca
     6481 gaacagagca aggcaatctc tttaaattaa ccgctcttgc aaaactatct aatgaggata
     6541 gtaaactcat ccaatatggc ttacaaggtc gcgtcactag tgtaactgca aagaaaacat
     6601 attttgatta tttcaaagat aaaattttaa cccattctga ttaattttca gataacactc
     6661 tataactatt tattatctta tcaaaaagga gaatcataac atggataaga aacaaaactt
     6721 aacttcattt caagaactaa caactaccga actcaaccaa attacaggtg gaggactgtg
     6781 ggaagatatc ttatacagcc ttaatataat taagcataac aatacgaaag gacttcatca
     6841 tccaatacaa ctataaaaaa taagaccgag taacaagaac tctcggtctt atttttttca
     6901 tcattctgta ggtatcatag taagcacctg acgaaagact tgatcttgac aggtagtatt
     6961 taaactggca ttgggataac tttccacaat cttcataacg gtatagagac cgacacctct
     7021 ctcctcccct ttagaactaa ctccaaagga gaagatttca gaaatatcga tgccctcttc
     7081 tttgatggag ttttcaatga taaaagtctc ctgtgctcca ctttttaaaa aggcaattga
     7141 aacatgaggt tgaccggcct ctgcactcgc ttcaatagca ttatcacaaa ggatagacac
     7201 aatggttaga aaatcaagca gtctcatccc ctcaacctga atctcttcag gaacttcgac
     7261 attaaagaca atgtcctttt ctctagcttt tataaatttt ccagctagga gacttttgag
     7321 ggcacgatcc cgaacattca ccaatctgcc caggtcatat ttattgtcct gcaatttctg
     7381 actggaatcc cttaagacca agtcatagac ctcttttatc tgctccatat cctcctcttc
     7441 aatacccaga cgtaaacttg tcaagaggtt ggtgtagtca tggcgaaaac tccttacttc
     7501 cttgtaaagt tcctctatat gccgactata gcgttctata tctctatagc gcaagacctg
     7561 ctcttggtcc agtctatcat ggagtttgtc cttcaaatag gtatccaatt tcttgataac
     7621 ccccataaaa aataggaggt aaaacactag aatgagatgg cgaacagtcg ttgattgaat
     7681 accttgctca tattcaaagt aagacagact ttgtatcacc aaatagtaag cccccattat
     7741 ccagttaatc ttagtcaggg acttttgaaa acctgtatct agaatctccc ttctcaaact
     7801 agtaaaatca tagtccaacc atttcaaaaa ggctagagaa atgaagaaat tgaaaattat
     7861 tatacataac ccagtaaatg agtagccatc atatacttgc tcttgtccca aaaatggaag
     7921 cacaaaatag gagactcctc tataaaagag attcaccaat atcattggaa agagaccata
     7981 aaagaaaagg agttttttag gaagccctct taacaataag aaagacaagc ctatgccgta
     8041 caagggttcc ataaaataag ataggtaaac atttcctacc atatagccaa tcattacaaa
     8101 aacaaaggcc aacagtatct tcaaaagaaa ggccttaaaa atcctctcaa aagtgagacc
     8161 aattccatct accttaaaga aaatgacaat ttttaatccg tgagtaacaa gtgtatacaa
     8221 caatatccaa gcaacattca taaactctcc tagctcagtg taagttatta atagcctcag
     8281 acacttccct gaccttataa cgcgcgatca gacagcttcc accattggga aagaaaagga
     8341 gtttttcttt cttatccaaa tgcaccacat ttgcaggatt gatgagaaaa gagcgatggc
     8401 actgcaagag acggggttcc tgcttaaaaa cctcctctaa actcgccgta aattctagcc
     8461 tgtccgtctt ggtatagaga ataacacgat ggggtcttgg ggatgtttcg agatagtaaa
     8521 cctctttgaa aggatattgg aattgggcaa attttgattt aaagtaaaag caatcttccg
     8581 ccagactttt actatcttga ctattggcat agaggagggc tgtctcgata cgagattcaa
     8641 actcctctgc cgaaagggcc ttatcaatgt agtccaaagc tgacacttgg tagcgaaagg
     8701 acagaggcat aaactccgag tgagtcgtca caaagacgat tagggcataa gggtcttgtt
     8761 cccgaatctt tctagctact tccagtccct tcatctcttc atttcgaatc tcaatatcca
     8821 aaaagaatag ctgatgggcc cccttctcat gcacctctgc cagcagttgg tccggcttgc
     8881 caaatacctc aaaagagcta ggaatgatat gatgtgcttt caaaagtttc tcaatcgtcg
     8941 tttcaattct agtctgttgg gaaaaatcat cttctaaaac aaatattctc atcttcttac
     9001 tctccctctt tcaaccattt ttgacgtatt tctctatagc gacgtctggc atacttgaca
     9061 gcatattgac cttcttctcc gagaaaaagg attctttctt gaaaatcaat cgattttaat
     9121 ttatcaagat taaccaaaca atttcgatga catctcatca aagtttcccc acattggttc
     9181 tcaagattac ttaaattttg aagcatatta aaactagctt tttctgtaac aatctgtacg
     9241 gtatgggctt tagttggatg tgtttggata tagtagatat cgtcgatgtt tactttatag
     9301 actgttttct gtgtctgaat aatcatatgt ttcattggat tctcctccta agaaaagaat
     9361 aacagaaaag gtctagccca agcacaccca atcctaaaca gtctttgaaa actcctaaaa
     9421 ggattatttt ctacaacatc atgatgagct tacaactatt ttatcataaa attcactcag
     9481 cgcaattcaa gacatttcaa tgacaattaa agatttgaat aaaaaaaaag aattaaaagt
     9541 gataaactaa cagtatcaaa acacagttgc cagaagtaag actggcaccc agattaaagg
     9601 aggcattccc atgacagata cagaccccat caaaagagct catactttga ttactgactt
     9661 aaacaaagcc taccaagcat gcaaacaggc aagcgctgac gacgtccgct ttcaggagca
     9721 attaaactct attcttggtt ttctagccaa ggctgaaaca gtggataatc gattcttgat
     9781 tgaactagaa aaattttacc agacttccag tcttctcatg ggactcagcg ctcttgatcc
     9841 agatgctcca actcgcgccg cttggcgggc ctatgaccgc ttccactttg accaagtcaa
     9901 gaccaagtta atactcaatg agaatcaaag agcaaactag gaagctagcc gcaagctgta
     9961 cttgagtacg gtaaggcgac gctgacgtgg tttgaagaga ttttcgaaga gtataagtct
    10021 ctacggacca accattatcc tgtagtaaca aaaaagaagc tgagacagac tgaactcaac
    10081 ttctttttta gtgtcgtatc agcaatgtta gtcctgcatc tgacgtttta cctgataagg
    10141 caaatacaag actagtaaaa ccaaaccagc tcctagtaag gctagaaggg ccagtttttc
    10201 ttggaaggta atcaacccaa caactaattc cacaagtaaa acaaaactgg tcaatcctcg
    10261 aactacctcc tgcaagcctt tttccttttg ccccttgtcc agcggaaaga gttgggtcaa
    10321 atactggtag tcaaaggcat gatagagggc cagcaactgg aagagcaaga ggtagttaaa
    10381 gagaactacc actgctgtcg caatccaagc ttgctcgata aaaacctgcg ccagtacgga
    10441 aagtaataga agacgaagac tgagagcaaa gaggtcgcca tttcgcagat aagaacgcag
    10501 atagagattt tgccaaatct tcccaggcac cttctgaaca gcctttaaga taaagtccag
    10561 ataggcacga cgcttaacgc tgtttgaaat tcccttgacc tgcgtaaaga gggcaaagaa
    10621 acgaagcaag acttgcttac gcttgctttc ttgagaaata acatagtccc agtccagtcc
    10681 agtttcagtg aaaaatttgc tggccttttg acgaaagtgg aaatattttc ctacccccaa
    10741 taaaagcaca tagagcagaa aaactggcaa gccataaccc attgctaaaa ataaaggcgc
    10801 aaataacagc aagaaaaggg tctgtacaaa gagccaaaag actagggaaa tgccagtttg
    10861 acgcttgaga tggagcttga tttcctcttc tccaactaag agaaagagct tgtctggagc
    10921 ctccatatag gtggcaattc ctccccaaag taaaagtaaa acagacgtaa ttcctacaaa
    10981 caaaaggata ggccaatgat tttcaggaaa atgttgtaag agttgactgt actggtaggc
    11041 tagaaagccc aacaggacaa gcaggaacaa gacaaagtgg tcattgagca catagcgcag
    11101 ataaccaaga cactccttac gaaaggcctg ctttctcttt aaaaacaagt ctttcatagg
    11161 tcctcctctt ttgtcagagc caagtaaata tcattcaaac tagcctcagg catatcaaag
    11221 gcttcgcgta gttgcaggag attgcctttg gcacgcacct ctcccttgtg aagaatgaca
    11281 aaggcatcac acatctt
//
LOCUS       DBMVGT010000056        11187 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.056, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000056 DBMVGT010000000
VERSION     DBMVGT010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 11187)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11187)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11187
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.056"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..627)
                     /locus_tag="AC0DU4_001614"
     CDS             complement(<1..627)
                     /locus_tag="AC0DU4_001614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase U32 family protein"
                     /protein_id="HIN4237549.1"
                     /translation="MTKTLKRPEVLSPAGTLEKLKVAVQYGADAVFIGGQAYGLRSRA
                     GNFTFEQMEEGVQFAAKYGAKVYVAANMVMHEGNEAGAGEWFRKLRDIGIAAVIVSDP
                     TLIMIAATEAPGLEIHLSTQASATNYETLEFWKELGLTRVVLAREVSMEELAEIRKRT
                     DVEIEAFVHGAMCISYSGRCTLSNHMSMRDANRGGCSQSCRWKYDLYDM"
     gene            1224..1808
                     /locus_tag="AC0DU4_001615"
                     /pseudo
     CDS             1224..1808
                     /locus_tag="AC0DU4_001615"
                     /inference="COORDINATES: protein motif:HMM:NF021048.6"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ApaLI family restriction endonuclease"
     gene            1805..2995
                     /locus_tag="AC0DU4_001616"
     CDS             1805..2995
                     /locus_tag="AC0DU4_001616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-methyltransferase"
                     /protein_id="HIN4237550.1"
                     /translation="MTVLKGDNLEILKTIESSSIDLIYMDPPFFTQKTQKLSNNKNIM
                     YSFEDTWTSIEDYKEFLSVRLEECKRVLKNSGSIFVHCDKIANHHIRLILDNIFGSDM
                     FQSEIIWNYKRWSNSKKGLLNNHQNIYFYSKSKDFKFNTIFTEYSSTTNIDQILVERK
                     RDGNSKTIYKVDNNGNYILAKEKNGVPLSDVWNIPFLNPKAKERVGYPTQKPILLLEQ
                     IIKIATDKNDIVLDPFCGSGTTLVASKILNRNYMGIDLSEEAINITQQRLENVIKTSS
                     NLLNKGIEAYRTKTEEEENILKLLQAKIVQRNKGIDGFLPKHFQKKPIPIKIQKNNEC
                     LNESISLLQNAINSKKLDFGVVIKTHSDNLLFDFDTIPENIIVVDHFELTIEKWLSKS
                     QQLL"
     gene            complement(3510..4502)
                     /locus_tag="AC0DU4_001617"
     CDS             complement(3510..4502)
                     /locus_tag="AC0DU4_001617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000122906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237551.1"
                     /translation="MSYYDFVKDYMKVDECKNNEKYSSAGHTFCWKKENSTYAEGLYW
                     FYEGGSFIIDIHDFYIKEEVVQNSTYSMSDYVSIYSSYIVSANGEKFNPYQTITANSL
                     CTFDFDNIKDDFVFLLHENCCYLAVSIGFKKELIEKHLASININPESFYSTLLQPNQI
                     ILTKALERVAMEILNCKMDAPAADFFFKAKANEWISIVIDTYLNRKKYKIEIDDDKAL
                     EDVARFLDDHFATNVNQGTLEKISKMSGTKLKNLFKEKYCQSITEYTQRKRMNVAETL
                     LLNTELPIKEIAESVGYSSASKFSIYYKRYKGKLPSEVRNLACKHHNFKCDYCD"
     gene            4662..6416
                     /locus_tag="AC0DU4_001618"
     CDS             4662..6416
                     /locus_tag="AC0DU4_001618"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237552.1"
                     /translation="MKIYKKLFAYVQDKKYLGVLAIIFSAISALLTVYGYYLIYKFLD
                     KLIINSNLSGAESIALKSVITLTSGAIFYFVSGMFSHILGFRLETNLRKRGIDGLEKA
                     SFRFFDLNPSGQIRKIIDDNAAQTHQVVAHMIPDSSQAIITPVLVLALGFIVSIRVGI
                     ILLALTIIGGLILGAMMGEQEFMKIYQESLSKLSAETVEYVRGMQVVKIFKANVESFK
                     SFYKAIKDYSKYAYDYSLSCKRPYVLYQWLFFGLIAILIIPIVYFMTSLASAKVILLE
                     LIMILFLSGVLFVSFMRMMWYSMYISQGNYAVDTLEALYEDMQKDKLVHGNVNNFKNY
                     NIEFENVSFAYNDKAVIENLSFNLEEGKSYALVGSSGSGKSTVAKLISGFYNVNEGSI
                     KIGGIAISEYSDEALIKAISFVFQDSKLFKKSIYDNVALANKDATKDDVMRALKLAGC
                     DLILDKFPERENTIIGSKGVYLSGGEKQRIAIARAILKDSKIIIMDEASASIDPDNEF
                     ELQKAFKNLMKDKTVIMIAHRLSTIKDLDEIIVMDSGKIIERGSDKELMSKDTRYKSL
                     QEMFNSANEWRVSNERVL"
     gene            6400..8121
                     /locus_tag="AC0DU4_001619"
     CDS             6400..8121
                     /locus_tag="AC0DU4_001619"
                     /EC_number="7.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019214631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237553.1"
                     /translation="MKEFYKKRFALTDGGARNLSKATLASFFVYCINMLPAILLMIFA
                     QEVLENMGKSNGFYIVFSVLTLIAMYILLSIEYDKLYNTTYQESADLRIRTAENLSKL
                     PLSYFSKHDISDISQTIMADIEGIEHAMSHSIPKVGGMVLFFPLISVMMLAGNVKMGL
                     AVIIPSILSFIFIPLSKKYQVNGQNRYYDVLRKNSESFQENIEMQMEIKAYNLSKDIK
                     DDLYKKMEDSERVHLKAEVTTILTLSISSIFSFISLAVVIFVGVNLIINKEINSLYLI
                     GYLLAAMKIKDSLDASKEGLMEIFYLSPKIERLKEIQNQDLQEGDDYSLKKFDIDLKD
                     VEFAYNKDAKVLNGVSFKAKQGEVTALVGASGCGKTTILKLISRLYDYDKGQILIDGK
                     DIKEISTESLFDKVSIVFQDVVLFNQSVMENIRIGKQDASDEEVKRAAKLANCTDFIE
                     KMDKGFDTVIGENGAELSGGERQRLSIARAFLKDAPILILDEITASLDVNNEKKIQES
                     LNNLVKDKTVVIISHRMKSIENADKIVVLQNGRVESEGKHEELLQKSKIYKNLIEKTK
                     MAEEFIY"
     gene            8132..8761
                     /locus_tag="AC0DU4_001620"
     CDS             8132..8761
                     /locus_tag="AC0DU4_001620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000368976.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HIN4237554.1"
                     /translation="MDNKKLKVKDLVSIGVFGVIYFAFMFGVGMMGLIPILFLIYPTV
                     LAIVAGTVVMLFMAKVQKPWALFIFGMISPLVMFAAGHTYIVVVLSLIVMIIAELIRK
                     IGNYNSFKYNMLSYAIFSTWICSSLMQMLLAKEKYMEWSLMTMGKDYVDVLEKLITYP
                     HMALVALGAFLGGILGAYIGKALLKKHFSNGLYCVGYFTPCLILWCYLN"
     gene            8662..9219
                     /locus_tag="AC0DU4_001621"
     CDS             8662..9219
                     /locus_tag="AC0DU4_001621"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013990548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     component T family protein"
                     /protein_id="HIN4237555.1"
                     /translation="MYRQGSIEKTLFKWIILCGILYSLPNFMVLSELNPIVKMFLSIP
                     IVIRMFILPFMAASFMIKTSDVGAIISSMDKLKISKNVSIPIAVMFRFFPSFKEEKKN
                     IKMAMRVRGINFKNPVKYLEYVSVPLLIISSNISDDIAKAAETKAIENPIAKTRYIRV
                     KIQLIDFVYVLAVAGLIVGGLIWLK"
     gene            9207..10571
                     /locus_tag="AC0DU4_001622"
     CDS             9207..10571
                     /locus_tag="AC0DU4_001622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002837029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237556.1"
                     /translation="MVEIKNLSLDYGEEHILDDISLSIAEGECVLFTGKSGNGKSSLI
                     NSINGLAVRYDNAKTKGEIIIDGKNIKNLELYQISMLVSTVFQNPKTYFFNVNTTLEL
                     LFYLENIGLAREEMDRRLKDMLEIFPIKNLLNRNIFNLSGGEKQILCIAASYIAGTKI
                     IVMDEPSSNLDIKSISVLAKMLKILKEKGISIIVAEHRIYYLMDIVDRVFLIDKGKLK
                     KTYTRSEFLKLDKNELNALSLRDKELSKLKVPYLKEGGEYQIKNLSYKFTDDECLSLK
                     DISFKLGKIYGIIGSNGRGKSTLLRCLIGLEKKSKEEIYFKGEKLSKKERLKNSSLVM
                     QDVNHQLFTDEVFNELRLGVKNFDEEKAKIILKDLGLDEFIERHPMSLSGGQKQRLAI
                     ASVMCKNSPFVFFDEPSSGMDYSNMIKISELINKYKTMDKIIFIVSHDIEFLNEVADE
                     IFEL"
     gene            complement(11026..>11187)
                     /locus_tag="AC0DU4_001623"
     CDS             complement(11026..>11187)
                     /locus_tag="AC0DU4_001623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_050084071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase domain-containing protein"
                     /protein_id="HIN4237557.1"
                     /translation="IMSLLETAKRHQLNSEKYLSYLLECLPNEETLVNKEVLEAYLPW
                     TKVVQEKCK"
BASE COUNT         4101 a         1567 c         1900 g         3619 t
ORIGIN      
        1 catgtcgtaa aggtcgtatt tccaacggca tgactgagaa catccaccac ggttggcatc
       61 acgcatactc atgtggtttg aaagagtaca acgtccagag tatgaaatac acatagctcc
      121 atggacaaag gcttcaattt caacatctgt acgtttgcgg atttcagcta attcttccat
      181 tgaaacctca cgcgctaaaa cgacacgagt caagcctagc tctttccaga actcaagggt
      241 ttcatagtta gtggcactgg cttgggtaga aaggtggatt tcaaggcctg gtgcttcagt
      301 cgctgcaatc ataatcaagg ttgggtcaga tacgataact gctgcaatcc cgatatcacg
      361 cagtttacgg aaccactcac cagcaccagc ttcatttcct tcgtgcataa ccatattagc
      421 cgctacatag accttggcac catacttggc cgcaaactgc acgccttctt ccatctgttc
      481 gaaagtaaag tttcccgcac ggctacgaag accataggcc tgaccaccga taaagacagc
      541 atctgctcca tactgaacag ctacctttag cttctctaaa gtccctgcag gtgataaaac
      601 ctcaggacgt tttaatgttt ttgtcataat ttctcctatt tgcaatataa aagtttgaca
      661 tttttccttc tcattttata gtaaataaag gataaaatca agcctagacg gattgttttg
      721 acaattctaa tcttttagac tttgcataat aactgttaaa cagtcgaaaa ttatcccagt
      781 tttaacaagt agtcaaaaag tctagaaaag taaaaaccag tatccaaaga tactgactcg
      841 taaaaataca taaattagtc cttagatgac tactcccact ctgttgctcc tataatggaa
      901 aaggattgat acagtctaga atatcgcttt tttatttatt attctgatat aaaactgtta
      961 gaattgattt tttgttttat acccaaatat gaatagagac gtagctaata agttgaataa
     1021 catatttgga aaaatgagaa atagcaatat tactagaact tttagaaaca atcaatattt
     1081 aaaaagaaaa aagctcaaag aatttattaa accatgttat aatagatata gctataattt
     1141 tatttataac aagaggatag aaatgaccga attagaaaga aaaaatcgaa aaattagcta
     1201 agaaatattc tgataactta aacatcaaag ttcaagagag agttcgtgaa atggcaaatg
     1261 ataataagag ccattatttg atatacagag ttttaggtat ttcatttgaa gaaggagaaa
     1321 atatcgattt gtatcaaaat aaaggtcgtt ttttatacaa atatgctggt taatttttag
     1381 aagaagctgc agtactatcc tttaacgaaa aatttggtac agaaaatact taaaaagtta
     1441 acattcctaa ttctgaaagt acaaaaccta agacttttga aattgattgt ttagtcggaa
     1501 aaaaacacgc atacgaaata aaatggtggg atgcaactac agatggagac catataacta
     1561 aagaacacac tagaataaaa gttattcata acaaaggata tataccaatt cggttaatgt
     1621 tctactatcc aaatagaact caagctataa aaattcagca aactttagaa acattgtata
     1681 acggtattgg agggaaatat tattatggag attctgcctg ggaacattta agagcagtga
     1741 ccggtattga tttacttagt attctaacag atattgcaaa taaaaaaaca ggggtaaaat
     1801 caaaatgaca gtattaaaag gagataactt agaaatatta aaaactattg aatcctcaag
     1861 tattgattta atctatatgg accctccttt ctttacacag aaaacccaaa aattatctaa
     1921 taacaaaaat attatgtatt cattcgaaga tacgtggact tcgattgagg attacaaaga
     1981 atttttgtct gtaagattag aagaatgcaa aagagtgtta aaaaatagtg gcagcatttt
     2041 cgttcattgt gataaaattg caaatcatca tattagatta attttagata atatctttgg
     2101 atcagatatg tttcaaagcg aaattatatg gaactataaa cggtggtcta attcaaaaaa
     2161 gggattattg aacaatcatc aaaacattta cttttattca aagtcaaaag attttaaatt
     2221 taatacaatt tttacagagt attcttctac tacaaatatc gaccaaatac tagtggaacg
     2281 aaaacgagat ggaaactcta aaactatata taaagttgat aataatggta actatattct
     2341 agcaaaagag aaaaatggag ttcccctttc agatgtttgg aatataccat ttcttaatcc
     2401 aaaagctaaa gaaagagtag gttatcctac acaaaaacct attctgttat tagaacaaat
     2461 tataaagatt gctactgata aaaatgatat agttttagac ccgttctgtg gaagtggaac
     2521 tactttagta gcctccaaga ttttgaatag aaattatatg gggattgatt tatctgagga
     2581 agctatcaat ataactcagc aacgtctgga aaatgttata aaaacaagtt caaatttatt
     2641 gaataaagga atcgaagcat atagaaccaa aactgaggaa gaggaaaaca ttcttaaatt
     2701 attacaggca aaaattgttc aaagaaataa aggaattgat ggttttttac ctaaacattt
     2761 tcaaaaaaaa ccgataccta taaaaattca aaaaaataat gaatgtctga atgagagtat
     2821 ctctttatta cagaatgcta taaactccaa aaaacttgat tttggagtag ttataaaaac
     2881 tcattcagat aatttattat ttgattttga tacgattcct gaaaatataa tagtagttga
     2941 ccattttgaa cttacaatcg aaaaatggtt aagtaaaagt caacagttac tatagtttgc
     3001 aaattattta cagaaagaac aaaaatgctc tgaaacactg atttcaaagc atttttttgt
     3061 tagtttaaaa ttactcccat tcttcttttc caaacgtaca atatatccaa aaccattcaa
     3121 aatactagat tctatttttt ataatatcac taaatccacc taattatagg acgttttcag
     3181 atttttagtc ccgtcccagt cccagtaccg gagaaatatt gttttaatat aatatctctt
     3241 tttgtcttct aagctcttaa aagcaaaaga acaagtaaag agtcaagaca aggataaaaa
     3301 gtccatatta gggcaaataa aaagctttaa gacagatgac aaatctaagt caaataagaa
     3361 agaccatagc aaaggtgcag agagataaat attggcggtc ttcggactgc ctttattttt
     3421 ttatccattt ttcaaatcaa atttattcag actatatatg cacatataca cttaaattca
     3481 tataaaaaca tggcttgtaa aaaattactt taatcacaat aatcgcattt aaaattgtga
     3541 tgtttgcaag ctaaattacg gacttcactt ggaagttttc ccttgtatct tttataatag
     3601 atagaaaatt tgctggcaga tgaatatcca acagattctg ctatctcttt tataggtagt
     3661 tcagtgttta aaagaagagt ttcagctaca ttcattcttt ttctttgagt gtactctgta
     3721 atgctttgac aatatttttc cttaaataaa ttttttaatt tagtaccact cattttagat
     3781 attttttcaa gcgtgccttg atttacattc gttgcaaaat gatcatctaa gaatcttgct
     3841 acatcttcaa gtgctttatc atcatcaatt tcaattttat atttttttct atttaagtat
     3901 gtgtcaatta ctatacttat ccattcattt gcctttgctt taaagaaaaa atcagcggca
     3961 ggagcgtcca tcttacaatt taatatttcc attgccactc tttctaaggc ctttgtaagt
     4021 attatttgat tcggttgaag caaggttgaa taaaaagatt ctggattaat gttaatagat
     4081 gctaaatgtt tttctattag ctctttttta aaaccaatgg aaacagcaag ataacaacaa
     4141 ttctcgtgta ataaaaaaac aaaatcatct tttatattat caaaatcaaa agtacataga
     4201 gagtttgcgg taatagtttg atacggatta aacttttctc cgtttgcact gacaatgtaa
     4261 cttgaataaa ttgaaacata gtctgacata ctataagtgc tattttgaac tacttcctct
     4321 ttgatataaa aatcatgtat atcgataatg aagctgcctc cttcataaaa ccaatatagg
     4381 ccttctgcat aagttgaatt ctcttttttc caacaaaatg tatgacctgc acttgaatac
     4441 ttctcattgt ttttacattc atctactttc atataatctt ttacaaaatc ataatatgac
     4501 ataacacact atccctttta gacaatattc caattagcct tattaattca aaactattgt
     4561 attagtaatt ataacagatg tataatagaa aagcaatgat agatattatc aattaagcga
     4621 atttatatct aaaagggata ttaaagaaag gagatatgct tatgaagatt tacaaaaaac
     4681 tatttgctta tgtccaagat aagaaatatc ttggggtttt ggccataatt ttttctgcta
     4741 tatctgctct acttacagta tatggatatt atttaatcta caaatttcta gataagttaa
     4801 taattaattc aaatttatcc ggtgcagaga gtatagcatt aaaatctgtt attacactaa
     4861 caagtggagc gatattttat tttgtctcag gaatgttttc acatatcttg ggattcaggc
     4921 ttgaaacaaa tttaagaaaa aggggaatcg atggtctgga aaaagcaagt tttaggttct
     4981 ttgacttaaa tccatctggt caaataagaa agatcataga tgataatgca gcacaaactc
     5041 atcaggtggt agcacacatg attcccgata gttctcaggc aataatcaca cccgtacttg
     5101 tacttgcact tggctttata gtaagtataa gagttggcat aattttgctt gctcttacta
     5161 taattggtgg cttaatttta ggggcgatga tgggcgagca agaatttatg aagatatacc
     5221 aagaatccct atctaaacta agtgctgaaa ctgttgagta cgtgagagga atgcaagttg
     5281 taaaaatatt taaagcaaat gtagagtcat ttaaaagctt ttacaaggct ataaaagatt
     5341 actcaaagta tgcttatgat tattccctat cttgtaaaag gccttatgtt ttgtatcaat
     5401 ggttattttt tggactgatt gcaattttaa ttattcctat agtttatttt atgactagct
     5461 tagctagcgc aaaggtgatt ttacttgagc ttatcatgat tttattttta tcaggagttc
     5521 tctttgtttc attcatgaga atgatgtggt actccatgta tatttctcaa ggaaattatg
     5581 cagtagatac tttagaggcg ctttacgaag atatgcaaaa agacaaatta gtgcatggta
     5641 atgtcaataa ttttaaaaac tataatatag aatttgagaa tgttagcttt gcttataatg
     5701 ataaagctgt cattgaaaat ttatccttta atttagaaga aggaaagtcc tacgcacttg
     5761 tcggttcatc tggatcaggc aaatcaacag tagcaaaact tatatcaggt ttttacaatg
     5821 ttaatgaagg aagcataaag ataggcggga tagcaataag tgaatattct gacgaagcct
     5881 taattaaagc catttccttt gtttttcaag attcaaaatt attcaagaag agcatttatg
     5941 ataatgtagc tttagctaat aaagatgcga cgaaagatga cgttatgaga gccttaaaat
     6001 tagcaggatg cgatttaata ttagacaaat tcccagaaag agaaaataca atcataggct
     6061 caaaaggtgt ttatttatcc ggtggagaaa aacaaagaat tgcaattgct agagcaattt
     6121 taaaggattc caaaattatt attatggatg aagcatcagc atctattgac ccagataacg
     6181 agtttgaatt gcaaaaagct tttaaaaatc ttatgaagga taaaacagtt atcatgattg
     6241 cacacaggct atctacaatt aaagaccttg atgaaattat tgtcatggat agtggaaaaa
     6301 ttatagaaag agggtctgac aaagaattaa tgtcaaaaga tacaaggtat aagagcctgc
     6361 aagagatgtt taacagtgcg aatgaatgga gggtttcaaa tgaaagagtt ttataaaaaa
     6421 agatttgctc ttacagatgg aggagcaaga aatttaagta aagcaacact ggcttcattt
     6481 ttcgtttatt gtataaacat gcttcctgcc atattactta tgatttttgc tcaggaagtt
     6541 ttggaaaata tgggcaaaag caatggcttt tatatagtat tctcagtttt gactttgata
     6601 gcaatgtata ttttgctttc tatcgaatac gataaattat ataacacaac ctatcaagaa
     6661 agtgcagatt taagaataag gacagcggag aatttatcaa aattacctct atcttacttt
     6721 tctaaacatg acatttccga catttcacaa acaatcatgg ctgatattga aggcatagag
     6781 catgcaatga gccactcaat accaaaggtg ggcggcatgg tactgttttt cccattaata
     6841 tctgtaatga tgctagcggg caatgtcaag atgggtttag ctgtaattat tccatctatt
     6901 ttaagcttta tatttatacc tttatctaaa aaatatcagg ttaatggaca gaatagatat
     6961 tatgatgtct taagaaaaaa ctcagaaagc tttcaagaaa atatcgaaat gcaaatggag
     7021 attaaagcat ataatttatc gaaggatatt aaagatgact tatataaaaa aatggaagat
     7081 agtgagagag tacacttaaa ggcggaagta actacaattt taactttgtc tatatcttca
     7141 atatttagct ttatatctct tgctgttgtg atatttgtcg gcgtaaatct aattattaat
     7201 aaagagataa attctctcta ccttatagga tatttactag ctgctatgaa gataaaagac
     7261 tctttagatg catctaaaga gggcttgatg gaaatatttt atttatcgcc caaaatagaa
     7321 agattaaaag aaattcaaaa tcaagattta caagaaggcg atgactatag cttaaaaaaa
     7381 tttgatattg atctaaaaga tgttgagttt gcctacaata aagacgcaaa agttttaaat
     7441 ggtgtaagtt ttaaagctaa gcagggagag gtcactgctt tggtaggtgc aagtggctgc
     7501 ggtaaaacaa ctatcttgaa acttatatca agactttatg attatgacaa gggacaaatc
     7561 ttaatcgatg gcaaagatat aaaagaaata tcaacagaat ctctttttga taaggtctct
     7621 atagttttcc aagatgtggt tctctttaat caaagcgtta tggaaaatat tagaatcgga
     7681 aagcaagatg caagtgacga agaggttaaa agagcagcaa aacttgcaaa ttgcacagat
     7741 tttatagaaa aaatggataa aggtttcgat acagttattg gtgagaacgg agctgagcta
     7801 tcaggaggag aaagacaaag attatcaata gccagagcct tcttaaaaga tgcgccgata
     7861 ttgatcttag atgagataac agcaagcctt gatgttaaca acgagaaaaa gattcaagag
     7921 tctttaaata atttagttaa agataaaact gttgtaatca tttcacatag aatgaaatcc
     7981 atagaaaatg cagacaagat agtagttctt caaaacggaa gagtagaaag cgaaggtaag
     8041 catgaagagc ttttacaaaa atcaaaaatt tacaaaaatt taatagaaaa gacaaaaatg
     8101 gcagaagaat ttatttatta ggaggactac aatggataat aaaaaattaa aagtaaaaga
     8161 tttagtaagt atcggtgttt ttggcgtaat ttattttgcc ttcatgtttg gagttggtat
     8221 gatgggcttg attccaatat tgttcttaat atacccgaca gtattagcca tagttgcagg
     8281 aactgttgtt atgttattta tggctaaggt tcaaaagcca tgggcactat ttatatttgg
     8341 tatgatatca ccacttgtga tgtttgcagc tggtcatacc tacatagttg tggttttatc
     8401 acttatagta atgataatag cagaattaat tagaaagatt ggtaattata attcatttaa
     8461 atacaatatg ctttcttatg caatcttcag cacatggata tgtagctctt taatgcaaat
     8521 gcttttagca aaagaaaaat atatggagtg gtctttgatg acgatgggaa aagattatgt
     8581 tgatgtatta gaaaagttaa taacttatcc tcacatggct ttagtagcct taggtgcttt
     8641 cttaggagga attcttggag catatatagg caaggctcta ttgaaaaaac acttttcaaa
     8701 tggattatat tgtgtgggat actttactcc ttgcctaatt ttatggtgtt atctgaatta
     8761 aaccctatag ttaagatgtt tttgagtata cctattgtta ttagaatgtt tattttacca
     8821 tttatggcag caagctttat gataaagacc tcggatgtag gcgcaataat ttcatcgatg
     8881 gataagctta agatttcaaa gaatgtatcc atacctattg cggttatgtt tagattcttc
     8941 ccatctttta aggaggagaa gaaaaacatc aaaatggcta tgagagtaag agggataaat
     9001 tttaaaaacc cagtcaaata tcttgaatat gtttctgtgc cactactcat tatatcatct
     9061 aatatatcag atgacattgc aaaagcggca gaaacaaagg caatagaaaa tccaattgcc
     9121 aagaccagat acattcgcgt aaagatacag ctaattgatt ttgtttatgt tttagcggtt
     9181 gctggactta ttgtgggagg attaatatgg ttgaaataaa aaatttaagt cttgattatg
     9241 gtgaagagca tatattagat gatatatcac tatccatagc cgagggagag tgcgtgctat
     9301 ttacaggaaa aagtggaaat ggtaagtcat ctttaataaa ttcaatcaat ggactagctg
     9361 taaggtatga caacgcaaag acaaagggcg aaataattat tgatggtaag aatataaaaa
     9421 atttggaact ttatcaaatc tcaatgcttg tttcaactgt ttttcaaaat cctaagacat
     9481 atttttttaa tgtcaatacg acattagaat tattatttta tttggaaaat atcggtcttg
     9541 caagagaaga gatggacagg cgtttgaagg atatgcttga gatattcccg ataaaaaatc
     9601 ttttaaacag aaatatattt aatctatccg gcggtgaaaa acaaattctt tgcattgcag
     9661 cttcttatat agcaggtaca aagattatag ttatggatga gccttcatcg aatttagata
     9721 ttaaaagcat aagtgttttg gcaaagatgc taaagatatt aaaagagaaa ggcataagca
     9781 taattgttgc agagcataga atttattatt tgatggacat agttgaccgt gtatttttaa
     9841 tagataaagg aaagcttaaa aaaacttata ctagaagtga atttttaaag ctagataaaa
     9901 atgaattaaa tgctttaagt ttaagagata aagaattaag taaattaaaa gttccttatt
     9961 taaaagaagg tggagagtat cagataaaaa atcttagcta caaatttact gatgatgagt
    10021 gtttaagctt aaaagatatt tcgttcaagc ttgggaaaat ttatggcata ataggatcca
    10081 acggacgagg aaaatcaacg cttttaagat gtttaatagg tcttgagaaa aaatcaaaag
    10141 aagaaattta ttttaaggga gagaagctat ctaaaaaaga aagactcaaa aactcttcac
    10201 ttgttatgca agatgtaaat catcaattat tcacagatga agtattcaac gagcttagat
    10261 taggagtaaa gaattttgat gaagaaaagg cgaaaatcat cttaaaagat ttaggcctgg
    10321 acgaatttat tgaaaggcat ccgatgagtt tatcaggagg gcaaaagcaa aggcttgcaa
    10381 tagcatctgt tatgtgcaag aattctccat ttgtcttttt tgacgaacct tcaagtggta
    10441 tggattattc caatatgata aaaatatctg aactgattaa taagtataaa accatggata
    10501 aaataatttt tattgtttcc catgatatag aatttttaaa tgaagtggca gatgaaattt
    10561 ttgaattgta aaatagagtc tgttaaacat gtctatagaa ctagtaaatt gtctaaaaat
    10621 ttaaaagata ctaacacata ttgatattta ttagaaaatt aacttcagga tttttacagt
    10681 atttataaac tttataatat gtatttatag tattaataat ttccatatct ttagggaaat
    10741 tctttattta cttaccataa ttaaagagat gagagataaa tatcggcagt cttcggactg
    10801 cctttatttt tttacttaat ttaatgcagt aaatcatacg attgaaagga atctgcttta
    10861 tatgctataa ttaggtggtt aatctataca tttagaaagg taaaatatag aattggagaa
    10921 tgatatggga ttttcatata ataaattgta accgcccaat aacgaagtct attgaaaaat
    10981 ctccagacta gagaactcac ggatagttcc taatctggag atttcttatt tgcacttttc
    11041 ttgtacaact ttagtccatg gtaaataagc ctctaaaact tctttgttta cgagagtttc
    11101 ctcgtttgga agacattcta gaagatagga tagatatttc tcactattta gttgatgacg
    11161 tttagctgtt tccaacaaac tcataat
//
LOCUS       DBMVGT010000057        10726 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.057, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000057 DBMVGT010000000
VERSION     DBMVGT010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10726)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10726)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10726
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.057"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(2..238)
                     /gene="rpsT"
                     /locus_tag="AC0DU4_001624"
     CDS             complement(2..238)
                     /gene="rpsT"
                     /locus_tag="AC0DU4_001624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HIN4237558.1"
                     /translation="MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELF
                     RAASSAIDKAETKGLIHKNKASRDKARLSAKLAK"
     gene            complement(306..1226)
                     /gene="coaA"
                     /locus_tag="AC0DU4_001625"
     CDS             complement(306..1226)
                     /gene="coaA"
                     /locus_tag="AC0DU4_001625"
                     /EC_number="2.7.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004594 - pantothenate kinase activity
                     [Evidence IEA];
                     GO_process: GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I pantothenate kinase"
                     /protein_id="HIN4237559.1"
                     /translation="MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISL
                     QDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSR
                     LLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIK
                     NGQDVDIPVYSHEVYDIVPEEKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIY
                     VDAGVDDIESWYLDRFLKMLSLAQNDSDSYYYRFTQMPIGEVEAFAHQVWTSINLTNL
                     QNYIEPTRNRAEVILHKSKNHEIDEIYLKK"
     gene            1416..1819
                     /locus_tag="AC0DU4_001626"
                     /pseudo
     CDS             1416..1819
                     /locus_tag="AC0DU4_001626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698118.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            2026..2616
                     /locus_tag="AC0DU4_001627"
     CDS             2026..2616
                     /locus_tag="AC0DU4_001627"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA];
                     GO_process: GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HIN4237560.1"
                     /translation="MSKMYYAENPDAAHDIHELRVDLLGEKMTFLTDAGVFSKKMVDF
                     GSQLLLKCLDVNQGETVLDVGCGYGPLGLSLVKVYGVQATMVDINTRALDLAQRNAEK
                     NNAKATIFQSNIYARVQGRFDHVISNPPIRAGKQVVHEIIEKSKDFLEIGGDLTIVIQ
                     KKQGAPSAKSKMEDVFGNCEILKKDKGYYILRSVKE"
     gene            2613..3890
                     /locus_tag="AC0DU4_001628"
     CDS             2613..3890
                     /locus_tag="AC0DU4_001628"
                     /EC_number="2.4.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001202959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016154 - pyrimidine-nucleoside
                     phosphorylase activity [Evidence IEA];
                     GO_process: GO:0006213 - pyrimidine nucleoside metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="HIN4237561.1"
                     /translation="MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMA
                     VYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVDKHSTGGVGDKVTLILAPLVASF
                     GVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
                     DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELA
                     QTMVDLGKVVGRKTVAVITDMSQPLGRAIGNRLEILEALEILQGQGRQDITHFICELA
                     QIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQ
                     ETGVISALPAMDFGLYAMRLGAGRAVKSDALDYETGIVFEKKIGDSVQKGEIVAKVYT
                     NEKIPPQLVTDFQKCVKISDEVKKIREIVEIIS"
     gene            3908..4570
                     /gene="deoC"
                     /locus_tag="AC0DU4_001629"
     CDS             3908..4570
                     /gene="deoC"
                     /locus_tag="AC0DU4_001629"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004139 - deoxyribose-phosphate aldolase
                     activity [Evidence IEA];
                     GO_process: GO:0009264 - deoxyribonucleotide catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HIN4237562.1"
                     /translation="MKLNKYIDHTLLKQDAKKKQIDSLLSEAREYDFASVCVNPTWVE
                     HAKKGLEGTDVKVCTVVGFPLGATTSAVKAFETKEAIQNGADEIDMVINVGALKSGNL
                     ALVESDIRAVVEASADKLVKVIIEACLLTDQEKIVVCQLAQKAGADFVKTSTGFSTGG
                     ATIADVTLMRETVGSDMGVKAAGGARSYADALAFVEAGATRIGTSAGVAILKGELADG
                     DY"
     gene            4557..4946
                     /locus_tag="AC0DU4_001630"
     CDS             4557..4946
                     /locus_tag="AC0DU4_001630"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004126 - cytidine deaminase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0009972 - cytidine deamination [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HIN4237563.1"
                     /translation="MATTELIELAIETSKHAYVPYSHFPIGAVLVAKDGNVYTGVNIE
                     NASYPLTNCGERTAIFKAISEGQREFSELIVYGQTEKPISPCGACRQVMVEFFEQDLK
                     VTLVAKDKSTVEMTVGELLPYSFTDLN"
     gene            5037..6089
                     /locus_tag="AC0DU4_001631"
     CDS             5037..6089
                     /locus_tag="AC0DU4_001631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family lipoprotein"
                     /protein_id="HIN4237564.1"
                     /translation="MNKKQWLGLGLVAVAAVGLAACGNRSSRNAASSSDVKTKAAIVT
                     DTGGVDDKSFNQSAWEGLQAWGKEHNLSKDNGFTYFQSTSEADYANNLQQAAGSYNLI
                     FGVGFALHNAVEEAAKEHTDLNYVLIDDVIKDQKNVASVTFADNESGYLAGVAAAKTT
                     KTKQVGFVGGIESEVISRFEAGFKAGVASVDPSIKVQVDYAGSFGDAAKGKTIAAAQY
                     AAGADIVYQVAGGTGAGVFAEAKSLNESRPENEKVWVIGVDRDQEAEGKYTSKDGKES
                     NFVLVSTLKQVGTTVKDISNKAEKGEFPGGQVIVYSLKDKGVDLAVTNLSEEGKKAVE
                     DAKAKILDGSVKVPEK"
     gene            6233..7768
                     /locus_tag="AC0DU4_001632"
     CDS             6233..7768
                     /locus_tag="AC0DU4_001632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000929819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237565.1"
                     /translation="MAHENVIEMRDITKVFGGFVANDKINLHLRKGEIHALLGENGAG
                     KSTLMNMLAGLLEPTSGEIAVNGQVVNLDSPSKAASLGIGMVHQHFMLVEAFTVAENI
                     ILGSELTKNGVLDIAGASKEIKALSERYGLAVDPSAKVADISVGAQQRVEILKTLYRG
                     ADILIFDEPTAVLTPSEIDELMAIMKNLVKEGKSIILITHKLDEIRAVSDRVTVIRRG
                     KSIETVEIAGATNADLAEMMVGRSVSFKTEKQASKPKEVVLSIKDLVVNENRGVPAVK
                     NLSLDVRAGEIVGIAGIDGNGQSELIQAITGLRKVESGSIELKGDSIVGLHPRQITEL
                     SVGHVPEDRHRDGLILEMMISENITLQTYYKEPHSKNGILNYSNITSYAKKLMEEFDV
                     RAASELVPAAALSGGNQQKAIIAREIDRDPDLLIVSQPTRGLDVGAIEYIHKRLIEER
                     DNGKAVLVVSFELDEILNVSDRIAVIHDGKIQGIVSPETTNKQELGVLMAGGNLGKEK
                     SDV"
     gene            7761..8819
                     /locus_tag="AC0DU4_001633"
     CDS             7761..8819
                     /locus_tag="AC0DU4_001633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237566.1"
                     /translation="MFKKLQQISVPLISVFLGILLGAIVMWIFGYDAIWGYEELFYTA
                     FGSLRGIGEIFRAMGPLVLIGLGFAVASRAGFFNVGLPGQALAGWILSGWFALSHPDM
                     PRPLMILATIVIALIAGGIVGAIPGILRAYLGTSEVIVTIMMNYIVLYVGNAFIHAFP
                     KDFMQSTDSTIRVGANATYQTPWLAELTGNSRMNIGIFFAIIAVAVIWFMLKKTTLGF
                     EIRAVGLNPHASEYAGISAKRTIILSMIISGALAGLGGAVEGLGTFQNVYVQGSSLAI
                     GFNGMAVSLLAANSPIGILFAAFLFGVLQVGAPGMNAAQVPSELVSIVTASIIFFVSV
                     HYLIERFVKPKKQVKGGK"
     gene            8822..9778
                     /locus_tag="AC0DU4_001634"
     CDS             8822..9778
                     /locus_tag="AC0DU4_001634"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237567.1"
                     /translation="MSIITLLPLLVSSMLIYSAPLIFTSIGGVFSERGGVVNVGLEGI
                     MVMGAFSGVVFNLEFAEQFGAATPWLSLLVAGLVGSVFSIIHAAATVHFRADHVVSGT
                     VLNLMAPALAVFLVKVLYNKGQTDNLSQTFGRFDFPVLANIPVIGDIFFKSTSLLGYL
                     AIAFSFLAWFILFKTQFGLRLRSVGEHPQAADTLGINVYKMRYLGIIISGFLGGIGGA
                     IYAQSISVNFSVTTIVGPGFIALAAMIFGKWNPIGAMLSSLFFGLSQSLAVIGSQLPF
                     LQGVPAVYLQIAPYVLTILVLAAFFGKAVAPKADGINYIKSK"
     gene            9862..10726
                     /locus_tag="AC0DU4_001635"
                     /pseudo
     CDS             9862..10726
                     /locus_tag="AC0DU4_001635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
BASE COUNT         3152 a         1875 c         2450 g         3249 t
ORIGIN      
        1 cttatttagc aagtttagct gaaagacgag ctttatcgcg gcttgctttg tttttgtgaa
       61 tcaaaccttt agtttctgct ttatcgatag ctgagctagc agcacggaaa agttcttcag
      121 atgggtttgc ttcgaaagct tttatagcag tacgcatagc tgatttttga gctgagttct
      181 tttcgttttg tttaacgttc aattcagcgc gtttgatagc tgatttaatg tttgccaatg
      241 ttcttacctc catatttact aactatacca ttatatatga aaacttacgt tttgacaagg
      301 gaaaattatt tttttaagta aatttcatcg atttcatggt tcttgctttt atgaagaatc
      361 acttctgcac gatttctggt tggttcaata taattttgta gatttgtgag attgatactg
      421 gtccagacct gatgggcaaa ggcttccact tccccaatcg gcatctgagt aaaacgataa
      481 tagtagctat cagagtcgtt ttgggctaga ctcagcattt tcaagaaacg gtccagatac
      541 caactttcaa tatcatccac tccagcatct acatagatgg aaaagtcaaa gaagtcagtg
      601 atatagagac gatcgttttg tggattttga aagacattga ttccctcaac aattacaaaa
      661 tcagcagctt tgacactttg tttctcttcg ggtacgatgt cgtaaacttc atgagaatag
      721 acaggaatat ctacatcttg tccatttttg atgcggtcca agaagttgag aagagcttcc
      781 atatcatagc tttcaggaaa tcctttacga tttaaaatcc cctgctcaat caaggtttga
      841 ttgggataga gaaaaccatc agttgtaacc aactcaaccg tagcatctgt aaacgtacgg
      901 gacagtagga tttgaagtag gcgactggtt gtggattttc caacggcaac actcccagaa
      961 accccaataa taaaaggttg agatttactt tcacgttgga ggaaaattcc ttttgaaaag
     1021 gctaaatctt ccttagttcg cttgtaaatc tgaatcagat gagccaaggg gagatagata
     1081 tctgtaacgt cttggagact gatttggtca ttaaaactct tgatagattc caattcttct
     1141 tctgtcaaag gaggtgttgt ctttcgatgt aaagattgcc aagtctggcg gctgattttt
     1201 tcaaaatgta aaaattcgtt ggtcatttgt tttcccctag atattttgtc tatcatacca
     1261 taaaaagcta aaaaaataaa gcggtttctt gaatgtggta agtcaatggt atatagtata
     1321 agtgatcaat ttattgatga aataggagat agattctact gatttataag cttataaagg
     1381 gggcttttta gttcacaact tataggaggt gtactatgaa aatcttaaaa cgttacatat
     1441 tggaactctg ttttatttta agttttgctt taccttttat aaaaggagcc aatgcagata
     1501 atggtagatg ctttgtggaa acctattacg gttttacttt tttgatggaa catgctattg
     1561 taacagctgt ctttatctgt tcgttcttaa ttgctttctt actaaaaaac gatgggcgaa
     1621 atggattgct gcgggtagtt attgcttttt agtcctacgg attgcgacag agggttattt
     1681 cttccacatg tcactagaag atttgatacg actttggaca agtttggaaa tcctgacaca
     1741 aacgtatcag ttgggctttt atctaaacat tttgttagga attttgttga taataaagta
     1801 ttttaaggtt aagcaataga aataataatc tgcctgatta tagatgataa actttttgtt
     1861 tttatctgga ctgtgatatt tatagttcta aatggtttat tatttataag tgttgaaaga
     1921 gattgaagaa aatggcttcg tgacttgctt tcttcggtct ttttcgtttt attatcaatt
     1981 tgtaaacgat ttacaatttg agtcaaatta tggtaaaata gtgtcatgag taaaatgtac
     2041 tatgcagaaa atcctgacgc tgctcacgac attcatgagt tgagagtgga cttgttggga
     2101 gaaaaaatga cttttttgac agatgcgggt gtttttagca agaaaatggt tgactttgga
     2161 agtcaactct tgctcaagtg tctggatgtc aaccaaggag agacagtcct agatgtaggc
     2221 tgtggctatg gtccattagg tttgtccttg gtcaaggttt acggagttca ggcgaccatg
     2281 gttgatatta acactcgtgc cctggattta gctcagagaa atgctgaaaa aaataatgca
     2341 aaagcgacga tatttcaatc taatatttat gcaagagttc aagggcgatt tgaccatgtc
     2401 atttccaatc ctcctatccg tgcgggcaag caagtcgttc atgaaatcat cgagaaaagt
     2461 aaagatttct tggaaattgg tggagatttg accatcgtca tccagaaaaa acaaggagct
     2521 ccaagtgcca agtctaagat ggaagatgtg tttggcaatt gtgaaatcct taaaaaagac
     2581 aagggatact atatccttag aagtgtgaaa gaatgagagc agttgattta atccaaaaaa
     2641 aacgagacgg tcaagaactg acttcaagtg aaattgaatg gctgatagaa ggctatgtat
     2701 caggaactgt tcctgattat cagatgtctg cctttgctat ggctgtttat tttaaaggaa
     2761 tgacgactcg agaaatctct gatttaacga tgaatatggt taagactggg caagagtttg
     2821 acctgtcagc cattgatggt gtgaaagttg acaagcattc tactggtggt gtcggcgata
     2881 aggtaacctt gattttagct cctcttgttg ctagcttcgg tgtgcctgta gcaaaaatga
     2941 gtggtcgtgg tcttggccat acaggcggaa caattgataa attggagtcc attaagggct
     3001 atcaagtaga acgtagtcaa gaggatttta ttcgtcaggt tcaggatatt ggagtatctg
     3061 tcattgggca atcagaccag ctggtcaaag cagataagct tctctatgcc cttcgtgatg
     3121 tgaccgcaac tgtcgacacg attcctttga ttgcgagttc ggtgatgagc aagaaaattg
     3181 cggcaggggc ggatgctatt ttgctagacg tgactgtcgg tgagggtgcc ttcatgaaga
     3241 cggttgatga ggcgcgtgag ttggctcaaa ctatggtaga tcttggtaag gttgttggac
     3301 ggaagacagt agcagtgatt acggatatga gccagccttt gggacgagcg attggaaatc
     3361 gtctggaaat ccttgaagca ttggagattt tgcaaggtca aggacgtcag gatattaccc
     3421 actttatttg tgaattggct caaattatgc ttggtttggc aaatgttaac aagactgttg
     3481 aagaagttcg ccaacatctt gagaatggtc aagcactggc taagtttgag gaaatggtgc
     3541 aagcccaagg tggagacttg gaagacctct atcgtcctgt aaatgtagct catgtggtgg
     3601 aaatccctgc tcaggaaacg ggtgtcattt cagctcttcc agctatggac tttggtcttt
     3661 atgccatgag gctgggtgct ggtcgtgcag ttaagtctga tgccttggac tatgaaacag
     3721 gaattgtttt tgaaaagaag attggagact ccgttcaaaa gggtgaaatt gttgcaaaag
     3781 tatacacaaa tgaaaaaatt ccacctcaac tagttacaga tttccaaaaa tgtgttaaaa
     3841 taagtgatga agtgaaaaaa atccgtgaaa ttgtagaaat catctcctaa atggagggaa
     3901 aaccgaaatg aaattaaata aatatataga tcatacgctt ttaaaacaag atgcaaagaa
     3961 aaaacaaatt gatagtttgt tgtctgaggc tagagagtat gactttgcca gtgtttgcgt
     4021 taatccgacc tgggttgaac atgctaaaaa aggacttgaa ggcacagatg ttaaggtttg
     4081 cacagtagta ggtttccctt tgggagcaac aacttcagcc gtgaaagcat ttgagacaaa
     4141 agaagctatc caaaatggtg cagatgagat tgatatggtg atcaatgttg gagctctcaa
     4201 atcaggtaat ttagccttgg ttgagtcaga tattcgcgca gtagtggaag caagtgctga
     4261 taagttagtg aaagtcatta ttgaagcttg ccttctgaca gaccaagaaa aaattgttgt
     4321 ttgccaattg gcccaaaaag ctggggctga ctttgttaaa acatctactg gtttttcaac
     4381 tggtggtgct acgatagcag atgttacatt aatgcgtgaa acagttggat ctgatatggg
     4441 agtcaaggct gctggtggag ctcgttctta tgcagatgct cttgcctttg tcgaagcagg
     4501 tgcgacccgt atcggaacgt cagctggggt agctatttta aaaggagaat tggcagatgg
     4561 cgactactga gttgattgaa ctggcaattg aaaccagcaa acatgcctat gtcccctatt
     4621 ctcactttcc tatcggagca gttttagtag ccaaagacgg aaatgtttac acgggagtga
     4681 atatcgaaaa tgctagctat cctttgacca attgcggtga gagaacagct atttttaagg
     4741 ctatatctga aggccaaaga gaattttcag aattgattgt ctatggtcaa actgaaaaac
     4801 cgatttcacc atgtggtgct tgtcgccaag taatggtcga attttttgaa caagatttaa
     4861 aagtgacctt agtcgcaaaa gataaatcga cggtcgagat gacggtcggg gagttacttc
     4921 catattcttt tacagactta aattagtctg agtcgctctt tgagtggcaa gggtctttgt
     4981 gaccaatcaa tccatacttg caacatcgtt gcacatctta tttaggaggt tcagtaatga
     5041 acaagaaaca atggctaggt cttggcctag ttgcagtggc agcagttgga cttgctgcat
     5101 gtggtaaccg ctcttctcgt aacgcagctt catcttctga tgtgaagaca aaagcagcaa
     5161 tcgtcactga tactggtggt gttgatgaca aatcattcaa ccaatcagct tgggaaggtt
     5221 tgcaggcttg gggtaaagaa cacaatcttt caaaagataa cggtttcact tacttccaat
     5281 caacaagtga agctgactac gctaacaact tgcaacaagc ggctggaagt tacaacctaa
     5341 tctttggtgt tggttttgcc cttcacaatg cagttgaaga agcagctaaa gaacacactg
     5401 acttgaacta tgtcttgatt gatgatgtga ttaaagacca aaagaatgtt gcgagtgtaa
     5461 ctttcgctga taatgagtca ggttaccttg caggtgtggc tgcagcaaaa acaactaaga
     5521 caaaacaagt tggttttgta ggtggtatcg aatctgaagt tatctctcgt tttgaagcag
     5581 gattcaaggc tggtgttgcg tcagtagacc catctatcaa agtccaagtt gactacgctg
     5641 gttcatttgg tgatgcggct aaaggtaaaa caattgcagc cgcacaatac gcagccggtg
     5701 cagatattgt ttaccaagta gctggtggta caggtgcagg tgtctttgca gaggcaaaat
     5761 ctctcaacga aagccgtcct gaaaatgaaa aagtttgggt tatcggtgtt gaccgtgacc
     5821 aagaagcaga aggtaaatac acttctaaag atggcaaaga atcaaacttt gttcttgtat
     5881 ctactttgaa acaagttggt acaactgtaa aagatatttc taacaaggca gaaaaaggag
     5941 aattccctgg cggtcaagtg atcgtttact cattgaagga taaaggggtt gacttggcag
     6001 taacaaacct ttcagaagaa ggtaaaaaag ctgtcgaaga tgcaaaagct aaaatccttg
     6061 atggaagcgt aaaagttcct gaaaaataat ggatggaagt catttcttag gaagcggcca
     6121 agggccgctt ttttaagagt tgagacaaag tcattttgtc tcagtaaagc ttgctactag
     6181 acaaactagc aagttttatt gaaataaaat aagactctga aaggaagagc acatggcaca
     6241 cgaaaatgtc attgagatgc gtgatattac caaggtgttt ggtggatttg ttgctaacga
     6301 caaaatcaac ttgcacctac gaaaaggtga aattcatgca cttttaggag aaaatggggc
     6361 tggtaagtcc acgctaatga acatgttagc agggcttctt gaaccaacta gtggtgaaat
     6421 cgcggtcaac ggtcaagttg tcaatctcga ctccccatct aaagcagcta gcttgggaat
     6481 cgggatggtt caccagcact ttatgttggt tgaagccttc acagtggctg aaaacatcat
     6541 tttaggtagt gaattgacta aaaatggtgt gctagatatc gctggagcta gcaaagaaat
     6601 caaggctctt tctgaacgtt atggcttagc tgttgaccct tctgccaagg tagcagatat
     6661 ctcagttgga gcccaacaac gtgtagaaat tttaaaaaca ctttatcggg gggctgatat
     6721 ccttatcttt gacgaaccaa cggctgtttt gactccatca gaaattgatg agttgatggc
     6781 tattatgaaa aatcttgtca aagaaggaaa atcaattatc ttgattaccc acaaattgga
     6841 tgaaattcga gcagtttctg accgtgttac agttatccgt cgtgggaaat caattgaaac
     6901 cgttgaaatt gcaggggcta ccaatgctga tttggcggaa atgatggtag gacgttctgt
     6961 ttcctttaaa acagagaagc aagcctctaa accaaaagaa gtggttttgt ctatcaaaga
     7021 tttggtggtc aatgaaaacc gtggtgttcc agctgttaaa aatctgtcct tggatgttcg
     7081 tgctggagag attgttggta ttgcggggat tgatggaaat ggtcagtctg aactgattca
     7141 agccattaca ggtcttcgta aggttgaatc tggtagcatt gagctaaaag gagattcaat
     7201 tgtaggcttg cacccacgtc agattacaga actaagtgtt gggcacgttc cagaagaccg
     7261 tcaccgtgat ggcttgattt tggaaatgat gatatctgaa aatattaccc ttcaaaccta
     7321 ctataaagaa ccacatagta aaaatggaat tttgaattat tcaaatatta cttcttatgc
     7381 taaaaagctg atggaagagt ttgatgttcg cgctgccagt gaattagttc ctgcagctgc
     7441 actctcagga ggaaatcaac aaaaagcaat tattgctcgt gaaattgatc gagatcctga
     7501 tctccttatc gttagccagc caactcgtgg gttggatgtc ggtgccattg agtatatcca
     7561 caaacgcttg attgaagagc gtgataatgg caaggctgtc cttgttgtca gctttgaatt
     7621 ggatgagatt ttaaacgtct cagaccgtat tgccgttatc cacgatggta agattcaagg
     7681 tattgtatca ccagaaacaa ccaataaaca agaacttggt gtcttgatgg ctggtggaaa
     7741 cttgggaaag gagaagagtg atgtttaaaa aattacaaca aatttcggtt cccttgattt
     7801 ctgtatttct aggaatttta ctcggagcca ttgtcatgtg gatcttcggt tatgatgcta
     7861 tttggggcta cgaagaattg ttctatacag cctttggcag tctgcgtggg attggagaaa
     7921 tcttccgtgc tatgggtcct ctggtcttga ttggtcttgg ttttgcggtt gccagtcgag
     7981 ctggtttctt taacgtcgga cttcctggtc aggctttggc aggttggatt ctcagtggtt
     8041 ggtttgccct gtcgcatcca gatatgcccc gtcccttgat gattctagca accatcgtga
     8101 ttgccttgat tgctggtggg attgtcggag cgattccagg tattcttagg gcctatctag
     8161 ggacgtcaga ggttattgta accatcatga tgaactacat tgtcttgtat gtagggaatg
     8221 cctttatcca tgctttccct aaagacttca tgcaaagtac agattcgacc attcgtgttg
     8281 gggctaatgc aacctatcag acaccttggt tggctgagtt gactggtaac tcacggatga
     8341 atattggtat tttctttgcc atcattgccg ttgcagttat ttggttcatg ctcaagaaaa
     8401 caactcttgg ttttgaaatc cgtgcagttg gtcttaatcc acatgcttca gaatatgctg
     8461 gtatttctgc caagcggact attatcctat ctatgattat ttcaggtgct ttggcaggtc
     8521 ttggtggagc tgttgaaggt ttgggaacct tccagaacgt ctatgttcaa ggttcgtcat
     8581 tagctatcgg atttaacgga atggcggtta gtttgcttgc ggccaactca ccaattggta
     8641 tactctttgc agccttccta tttggcgttc tccaagttgg ggctcctggt atgaatgcgg
     8701 cgcaggtacc atctgagctt gtcagcattg taacagcgtc tattatcttc tttgtcagtg
     8761 ttcattacct tatcgaacgc tttgttaaac cgaaaaaaca agttaaagga ggtaagtaaa
     8821 gatgtctatt ataaccttgc tccccctctt ggtgtcttct atgctgattt actcagcacc
     8881 tctcatcttt acaagtatcg gtggtgtttt ctctgaacgt ggtggtgtgg taaacgttgg
     8941 ccttgaagga attatggtta tgggtgcctt ttctggagtt gtctttaacc ttgaatttgc
     9001 agaacaattt ggagcagcaa ctccatggct atccttgctt gtagcaggat tggttggtag
     9061 tgttttctct atcatccacg cagcagcgac ggttcatttc cgtgcagacc atgttgtcag
     9121 cggtacggta ttgaacttga tggcgcctgc cttggctgtt ttcttagtta aagttcttta
     9181 taacaaagga caaaccgaca acctaagtca aacttttgga cgctttgatt tcccagtctt
     9241 ggcaaatatc ccagtgattg gtgatatctt cttcaagtca actagtctac ttggttatct
     9301 ggcgattgcc ttctcattcc ttgcttggtt tattctcttt aagactcaat ttggtcttcg
     9361 tctccgctct gtcggtgaac atcctcaagc agcggatacc ttgggaatca acgtctacaa
     9421 gatgagatat ttagggatta ttatttcagg ttttctaggt ggaattggcg gagcgattta
     9481 tgcgcaatca atctcagtta acttctcagt gacaactatt gttggacctg gatttatcgc
     9541 ccttgctgcg atgatctttg ggaaatggaa tccaatcggt gctatgcttt ctagtctctt
     9601 ctttggactt tcacaaagtt tggctgttat cggttctcaa ttgccgttcc tacaaggagt
     9661 gccagcggtt tatcttcaaa ttgcacctta tgttttgaca attcttgtct tagcagcctt
     9721 ctttggaaaa gcagtcgcac caaaagcaga tggtatcaac tacatcaaat caaaataagc
     9781 atacaaaaaa cgtcagttca atgactgaac tgccccccaa aagttagaca gaaaaaatct
     9841 aacttttggg gtgtttttat tatgaaacta acttatgatg ataaagttca gatctatgaa
     9901 cttagaaaac aaggatatag cttagagaag ctttcaaata aatttgggat aaacaattct
     9961 aatattaggt acatgattaa attgattgat cgttacggaa tagagttcgt caaaaaagga
    10021 aaaaatcgtt actattctcc tgatttaaaa caagaaatga ttcataaagt ctgacatgaa
    10081 ggctggacta aagatagagt ttctcttgaa tacggtctcc caagtcgtac gatacttctt
    10141 aactggctag cacaatacag gaaaaacggg tatactattg ttgagaaacc aagagggaga
    10201 gtacctaaaa tgggacgtaa tccaaaaacg agacctgaag agaggacaga attagaacgt
    10261 cttcaagcag aaaatgagta cctgagagcg gagaatgcca tcctaaaaaa gttaagagaa
    10321 ctccgattga aggaggaaaa agagaaagaa gaaagacaga aattgttcaa gaattaatga
    10381 ctgagttttc gttagatctt cttctaaaag ccattaaact agctcgttcg acctactact
    10441 atcacttgaa acagctaaac aaaacagata aggaccaaga gcttaaagct gaaattcaat
    10501 ccatctttat cgaacacaag ggaaattatg cttatcgtcg gatttattta gaactaagaa
    10561 atcgtggtta tctggtaaat cataaaagag ttcaacactt gatgaagtac tcaatttaca
    10621 agctaaaacg cgacagaaac gaaaatattc ttctcataaa ggagacgttg gcaagaaagc
    10681 agagaatctc attcaaggcc aatttgaagg ctctaaaaca atggaa
//
LOCUS       DBMVGT010000058        10489 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.058, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000058 DBMVGT010000000
VERSION     DBMVGT010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10489)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10489)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10489
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.058"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            9..89
                     /locus_tag="AC0DU4_001636"
     tRNA            9..89
                     /locus_tag="AC0DU4_001636"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:43..45,aa:Tyr,seq:gta)
     gene            94..164
                     /locus_tag="AC0DU4_001637"
     tRNA            94..164
                     /locus_tag="AC0DU4_001637"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:126..128,aa:Trp,seq:cca)
     gene            179..251
                     /locus_tag="AC0DU4_001638"
     tRNA            179..251
                     /locus_tag="AC0DU4_001638"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:212..214,aa:His,seq:gtg)
     gene            262..333
                     /locus_tag="AC0DU4_001639"
     tRNA            262..333
                     /locus_tag="AC0DU4_001639"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:294..296,aa:Gln,seq:ttg)
     gene            343..426
                     /locus_tag="AC0DU4_001640"
     tRNA            343..426
                     /locus_tag="AC0DU4_001640"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:377..379,aa:Leu,seq:caa)
     gene            complement(537..1268)
                     /locus_tag="AC0DU4_001641"
     CDS             complement(537..1268)
                     /locus_tag="AC0DU4_001641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001074368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HIN4237568.1"
                     /translation="MAKLYAISDIHGYLDEFRDALNKVNLNDKDNRLFLLGDYLDNGL
                     QSFQVISKIIELEEVYPNQIITLLGNHEEWFYDWLILDKPTASAFPETIKSFFSPEEL
                     NYIFKSNANNFETGVRNEIKNNIKFNPFINWFKKRYRDKRYYETDTQIFVHAGIDEEA
                     GMLWKELTSSKIFTNKFPITTGRFHKAIISGHIASWEVAKDRRYLGKIYYDSKSHYLI
                     DGDVTNSKTIPVLYYDTITQKYHFL"
     gene            complement(1261..1497)
                     /gene="relB"
                     /locus_tag="AC0DU4_001642"
     CDS             complement(1261..1497)
                     /gene="relB"
                     /locus_tag="AC0DU4_001642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB family
                     antitoxin"
                     /protein_id="HIN4237569.1"
                     /translation="MNNVVTTQISIQLSQELNSLLNAIVEENNTTKTDFIRQAVIEKI
                     EDMYDIKVADEAYKKWVECGKKATSHEEMMRRYG"
     gene            complement(1713..2150)
                     /locus_tag="AC0DU4_001643"
     CDS             complement(1713..2150)
                     /locus_tag="AC0DU4_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HIN4237570.1"
                     /translation="MDTSQVIKAHEVAKKAHFGQIDRAGIDYIKHPETVASFVATDEE
                     KAVAYLHDVIEDTSLTLLDLKKEGFSKNIIEAVDILTKKKGQDYQSYLNLVKKNELAR
                     VVKLADLRHNSDLTRLPLITEKDLERNKKYSSAIRFLRAKKKS"
     gene            complement(2191..3324)
                     /locus_tag="AC0DU4_001644"
     CDS             complement(2191..3324)
                     /locus_tag="AC0DU4_001644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0009009 - site-specific recombinase
                     activity [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HIN4237571.1"
                     /translation="MAIRKGKDGNWVVDISNGFDPITLKQRRLVRKGYKTKKEAIEAE
                     HYLRSVELKERFYGAKITIPILYELLKEEDSINHRKASYINTQDNNYNKHIKDYFSMV
                     DNVGKLTYEDIYQFREHLRQKVAKNSDKPLSTNTINKIMILLKKIFDVGLRKGYYSSN
                     PAKLIKKLPIEKTKMQFWTVKEFQKFLTLFEPEEYNIKLLFTVLFFTGLRLGEALALT
                     WQDIDFSSNTIHITKSVYVNKGVTHISTTKTKAETRRIVINKKLSQELQDWKKRQKHL
                     LEQFTNNSLTLQVFQNSPITITKNAIEKQYKKIIERDSTLKKIRIHDFRHSHASLLIN
                     QGEDYLVVKERLGHASITTTIDTYSHLYPSKQKDLADKLDDLL"
     gene            complement(3328..3531)
                     /locus_tag="AC0DU4_001645"
     CDS             complement(3328..3531)
                     /locus_tag="AC0DU4_001645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001823627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3173 family protein"
                     /protein_id="HIN4237572.1"
                     /translation="MIATVTKNDLIALGFFEGTSKRIIRQGKELLITRGFTVYQNKRI
                     GTIPATIATELLVFDVQNSTLKE"
     gene            complement(3545..4327)
                     /locus_tag="AC0DU4_001646"
     CDS             complement(3545..4327)
                     /locus_tag="AC0DU4_001646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004195527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rolling circle replication-associated protein"
                     /protein_id="HIN4237573.1"
                     /translation="MTSYNKKIVRTSSYIEIWEYEKPIFSKGKSILDTNTENKEKAKR
                     RTFDELTPLEQEQRLERMKKTRLEAKWNLLRLVDCNFDDTTSFLTLTTKENISDRNHF
                     KDSLKTFIKRFNYHIFNTKKSKLKYIAVLERQKRKAWHSHILLFSVPYIPHKQLLELW
                     GHGAVWINKVDVDSKENRGRYVTKYFEKGIGQELLENFGKQAYFSSRNLKKPDEDKFY
                     TYEDFNYDSSVVLYETEYTSKVYKYGQYFDNHVKYKKIRLDE"
     gene            complement(4511..5284)
                     /locus_tag="AC0DU4_001647"
     CDS             complement(4511..5284)
                     /locus_tag="AC0DU4_001647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HIN4237574.1"
                     /translation="MKTLLIGDLHLKSQLILPIVDKIIQTHNIKRIIFLGDYVDLHGQ
                     TNNIQLYAKDLTFLYSWKIDKEQNGIDVINLIGNHDAYYLLGEQAPFSIQNLEVFFAV
                     KELLQDLKLQIAYQLDDYLVSHAGFNLIFDPKEWHFNLYTKEYEEELDILAYTIGPMR
                     GGKALGGSPLWAHFRELELLPNQDFPKQIVGHTPKESIDISKNVIGIDTFSLYIDKDN
                     KYQFIGNGDLLVYDQGHLEIISTNWATDETLKQLSKPQI"
     gene            complement(5328..6098)
                     /locus_tag="AC0DU4_001648"
     CDS             complement(5328..6098)
                     /locus_tag="AC0DU4_001648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001029528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HIN4237575.1"
                     /translation="MAIYYSVSDIHGHYNEFIKSLNKIDLSDKQSKLILLGDYIDYGS
                     QSFQVISKIIELEKIYPKQIITLFGNHEEWFYDWLILDNPTASAFPETIKSFFSTEEL
                     NYILKTNPNNFETGVRNEIRNNDKYIPFINWFQKRYEDSRYFETENQIFVHAGIDEEA
                     NNLWKDLTSPEIFTNKFPITTGRFYKDIISGHFASWEVAKDKSYLGKIYHDSKSHYFI
                     DGDVKNSKTIPVICYDTVKKSYQYSKNTSLLPKKFDRA"
     gene            complement(6117..6506)
                     /locus_tag="AC0DU4_001649"
     CDS             complement(6117..6506)
                     /locus_tag="AC0DU4_001649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001165436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237576.1"
                     /translation="MQIFTYNDFLKDKEIVTFEQAEIILDELIKSSNIYDPEFQAYWK
                     ELIEYSAKYAEMRGKWRILTKEEQDTLDDTRTNIHNRIRDNLISIRGLAQINNKDTSW
                     FDKFHNDRKRMGDFANYINYIYAVNSR"
     gene            complement(6544..6858)
                     /locus_tag="AC0DU4_001650"
     CDS             complement(6544..6858)
                     /locus_tag="AC0DU4_001650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004195544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237577.1"
                     /translation="MKLNDFLKPELLGNKFIAVKGYTEVLDRETNKPVALRLNVSIQD
                     EDSDFFMEMIQVKVNTLSPTASVQEMANNKTCPVTLKDLNVGQYNGNLWFSCSNVILI
                     TK"
     gene            complement(6948..8270)
                     /locus_tag="AC0DU4_001651"
     CDS             complement(6948..8270)
                     /locus_tag="AC0DU4_001651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FtsK/SpoIIIE domain-containing protein"
                     /protein_id="HIN4237578.1"
                     /translation="MFKLRQSADLTRNNIISCYKLKIMHWLILSISACILFSTIVNIR
                     APTFVQILFIFLGGFIIYKIHLKIKIFRYDLEHYLIIRESLLYVLHTNRLYTTSKDGS
                     GYEKIVRSAVLEYEIDRQKGHVLIKALITGDEFSKKVQSLDDVLSDVLELELEEKIIR
                     PSFIEYHFYYIKPKRLVLQSHSQRQEIDSLDIDLGYGVNYNPVKCSHILVSGGTGSGK
                     SVLISVLILEFLKRQSTVYIADPKNSDLGSLSHYFGNKYVATTPNNIARIVRVVVEEM
                     QERYQVMRDNFQYGSNFTNHGFKPVWLIFDEMGAFQATGSDKKSREIITEVMDGIKQI
                     ILLGRQSGIFILVSAQQVNASTTLSTELRDNLGLRIALGANSSEGYHMVFGSATPDKL
                     KPIEEKGSGYLYIQGSGKESAQYWESPYLDTTQFDFIKELQLYVTKSK"
     gene            complement(8276..8494)
                     /locus_tag="AC0DU4_001652"
     CDS             complement(8276..8494)
                     /locus_tag="AC0DU4_001652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001282606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237579.1"
                     /translation="MSDNLKAYLFLLGFVILAGIAIFIFPQGHFFSNSILILGCIPLL
                     ISTYYFAKIKLLGFYELLKELLDKIKGI"
     gene            complement(8534..9289)
                     /locus_tag="AC0DU4_001653"
     CDS             complement(8534..9289)
                     /locus_tag="AC0DU4_001653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HIN4237580.1"
                     /translation="MIQLTASTWNINLRSRKGKQIPEMIAQELAQQNSDIICLTEYVK
                     TDNHSQFCSSLQTNGYTIFEDVRTIDFGNEILIAIKSDLVNDCQVITIDNDDNNPNFL
                     HVRVTIEGQELNIIGVRIKIGGENVFEDFKHRKTQLDKLIFNLPIHENTIILGDFNNG
                     FFKQNDDTHSYQGKPREFYSYPLLKSEMNKAGLTVHTPSEENSWKYCKLDHIIGNIPI
                     SNVCYSWRFLENPDYQNKVGFPDHAILSATISL"
     gene            complement(9718..10221)
                     /locus_tag="AC0DU4_001654"
     CDS             complement(9718..10221)
                     /locus_tag="AC0DU4_001654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237581.1"
                     /translation="MTQFQVRISGEAAYYLRMLKEKYETSEGINITKATILTRAFQNS
                     KTVTNWTKVVQDNSISLKNIYPVEEKELKLNVALSDEVAEGIKKYKEILPSATNTQSV
                     TLGVCVKFLLKAELMTQLNHDISEPEKDFDKKFSILEKQLLEIVAPVNHKLLSDTIWN
                     FKNNFIK"
BASE COUNT         3203 a         1719 c         1673 g         3894 t
ORIGIN      
        1 tatattttgg aagggtagcg aagaggctaa acgcggcgga ctgtaaatcc gctccttcgg
       61 gttcgggggt tcgaatccct ccccttccat tttacgggca tagtttaaag gtagaactaa
      121 ggtctccaaa accttcagtg tgggttcaat tcctactgcc cgtgttaata gaattatggc
      181 gggtgtggtg aagtggttaa cacaccagat tgtggctctg gcatgcgtgg gttcgatccc
      241 catcactcgc ctattttata ttggggtata gccaagcggt aaggcaaggg actttgactc
      301 cctcatgcgt tggttcgaat ccagctaccc cagttactat ttgccggcgt ggcggaattg
      361 gcagacgcgc tggactcaaa atccagtgtc cgcaaggacg tgccggttcg accccggccg
      421 ccggtatagt attaaagaca aggttttagg accttgtctt tttgttatgt cataagaaat
      481 ttcttggaat tgttactaat aattactaat ttcatataaa agcacatgat taaaagttat
      541 agaaagtgat atttttgggt aattgtatca tagtaaagaa caggtattgt tttgctattc
      601 gttacatctc catcaattaa gtaatgactt ttactatcat agtaaatctt acctaggtat
      661 cttctatctt tagctacttc ccaagaagca atatggcccg aaataatagc tttatgaaat
      721 ctaccagtgg taattggaaa tttgtttgta aatatctttg aactcgttag ttctttccaa
      781 agcattcctg cttcttcatc aatgcctgca tgaacaaaaa tttgggtatc agtttcataa
      841 tagcgtttat ccctatatcg ctttttaaac cagtttataa atgggttgaa tttgatatta
      901 tttttaattt catttctaac acctgtttca aagttgttag cattcgattt aaaaatatag
      961 ttcaattcct ctggagagaa gaagcttttt attgtttctg gaaatgctga agcagtaggt
     1021 ttatctaaaa tcaaccaatc ataaaaccat tcttcatgat tccctagaag agtaataatt
     1081 tgattaggat aaacctcctc aagttcgatt attttggaaa tgacttgaaa agattgaagt
     1141 ccattatcaa gataatctcc tagtaaaaat aggcgattat ctttatcgtt taaatttact
     1201 ttattgagag cgtctctgaa ttcatccaag tatccatgta tatcagatat tgcgtataat
     1261 ttagccatag cgtctcatca tttcttcatg tgaggtagct tttttgccac attcaaccca
     1321 ttttttataa gcttcatcag cgaccttaat atcatacata tcttcaattt tctctataac
     1381 agcttgtcta ataaagtcag tctttgttgt attattttct tcaacaatag catttaataa
     1441 agaatttaac tcttgactaa gttgaataga aatttgtgta gtaacaacat tattcatata
     1501 acagccacct aatagttatt ttagatacat tatactccta gtctaaaagt ttctcaataa
     1561 aaaatttcac tttttatagt tatttatttt aataaaattg tagtatctgc aaggatgtgc
     1621 cagttcgaga ccgaccgcca gtatagtaat aaagacaaag tttataagcc ttgtcttttg
     1681 ttttctcttt ataaaatttt atagtttagt tactaacttt ttttctttgc tcttaaaaat
     1741 ctaatagcag aactgtattt cttatttctc tctaagtctt tttcagtaat taatggtagt
     1801 cttgttaaat ctgaattatg ccgtaaatcc gccaacttta caactctagc gagttcattt
     1861 ttctttacta gattgagata agattgataa tcttgtcctt ttttctttgt gagtatatcg
     1921 acggcttcta taatgttttt tgaaaaacct tcctttttta ggtctagtag ggttagtgaa
     1981 gtatcttcaa ttacatcatg tagataggcg acagctttct cttcatcagt tgcgacaaaa
     2041 ctagctactg tttcagggtg tttaatgtag tcaattcctg ctctatcaat ttgtccaaag
     2101 tgtgcttttt tagctacttc atgtgctttt attacttgtg atgtatccat gatttaatta
     2161 taaactttcc atttataaaa ctcaattact ttatagtaaa tcatctagtt tatcagctaa
     2221 atccttttgc ttacttgggt acaagtgaga gtaggtatca atcgtggttg ttatagaagc
     2281 atgtcctagt cgctctttta caactagata atcttcccct tggttaatca gcagggaagc
     2341 gtgtgagtgc ctaaaatcgt gtatgcgtat cttttttagt gtgctatcac gttcaatgat
     2401 tttcttgtac tgcttttcaa tagcattttt tgtaattgtg ataggactat tttgaaacac
     2461 ttgtaatgtt aggctattgt tggtaaattg ctctaataga tgtttttgtc gctttttcca
     2521 atcttgtaat tcttggctta attttttatt gataacaatt cttcttgttt ctgctttagt
     2581 ttttgttgtg ctgatatgag ttactccttt attaacatag acagacttcg tgatatgaat
     2641 tgtattactt gaaaagtcga tgtcttgcca tgttagggca agagcttccc caagtcttaa
     2701 tcctgtaaag aatagaacag taaagagtag tttgatattg tattcttcgg gttcaaatag
     2761 tgtcaaaaac ttctgaaatt ctttgactgt ccaaaattgc atttttgttt tttcaattgg
     2821 caactttttt attaattttg ctggattgga ggagtaatag ccttttcgca aaccaacatc
     2881 aaaaattttt ttgagtaaaa tcatgatttt gttaatagta tttgtgctta acggtttatc
     2941 agaattttta gctacttttt gcctaagatg ttctctaaat tggtagatgt cttcataggt
     3001 tagttttccg acattatcga ccatagaaaa ataatctttg atgtgtttgt tgtaattatt
     3061 atcttgtgta ttgatatagc ttgcttttcg atgatttata ctatcttcct ccttaagtag
     3121 ttcatatagt atggggatag ttattttagc tccataaaag cgttctttta actctacact
     3181 tcgtaagtag tgttctgctt caatagcttc ttttttcgtc ttatagccct ttctgacaag
     3241 tctacgttgc tttagtgtta ttgggtcaaa accgttgcta atatcaacta cccaattacc
     3301 gtctttacct tttctaattg ccatatttta ctccttgagg gtactgtttt gaacatcaaa
     3361 aacgagtaat tcggtagcaa tagtagcagg tatagtacca attcgcttgt tctgatagac
     3421 tgtaaagcct cgggttatca gtagctcttt cccttggcgg ataatacgtt tagatgttcc
     3481 ctcaaagaaa ccgagggcaa ttaggtcatt cttagtaaca gttgctatca tgtgacttac
     3541 tcctttattc atctagtctt attttcttgt actttacatg attatcgaaa tactgaccgt
     3601 atttatagac cttactagtg tattccgttt catatagcac gactgaacta tcatagttaa
     3661 aatcttcata agtgtaaaat ttatcttcat caggcttttt caagttgcgt gatgaaaaat
     3721 aggcttgctt tccgaagttt tccaacaatt cttgtccaat acctttttca aaatactttg
     3781 tgacatatcg accgcgattt tctttgctgt cgacgtcaac tttatttatc catactgcac
     3841 catgccccca aagttctaat aattgcttat gtggaatata gggaacactg aatagcaaaa
     3901 tatgactatg ccatgcttta cgtttttgcc tctctaatac tgctatatat tttaatttac
     3961 ttttcttggt attaaaaatg tggtagttaa agcgtttaat aaatgttttg agtgagtctt
     4021 tgaagtggtt tctatcgctg atattttcct tagtggtcag tgtaagaaaa gaagttgtat
     4081 catcaaaatt acaatcaact agacggagta agttccactt ggcttctaag cgagtcttct
     4141 tcatacgttc aagacgttgt tcttgttcta ggggtgttag ttcatcaaat gttctgcgtt
     4201 ttgctttttc cttgttttca gtattagtat ctaaaataga ttttcctttt gaaaatattg
     4261 gcttttcata ttcccaaatt tcaatatagg aagaagtgcg gactattttt ttattatatg
     4321 aggtcataaa aaatagttcc ttttaggttg gctttcgcca aaagattgtc tatataataa
     4381 ataaactagg aggagcaaag ctcctccaca cttctatcat gtgtttctaa gcatcgctcc
     4441 gctaaacacg cttccagctt gctgacctcc agtcagcagt ttcgcttagt cacatgatga
     4501 gaagtagtag ttaaatttgt ggtttagata attgttttaa tgtttcgtct gtagcccagt
     4561 tggttgaaat gatttcaaga tggccttggt catagactag caaatctccg ttaccaataa
     4621 attgatattt attatctttg tcaatatata atgaaaaagt atctatacca ataacatttt
     4681 tagaaatatc aatagattct ttaggggtat gtccaacaat ttgtttagga aagtcttggt
     4741 tgggaagcaa ttctaattct ctaaaatgtg cccataaagg agaaccccca agagctttcc
     4801 caccacgcat tggtcctatt gtataagcta ggatatctaa ttcttcttca tactctttgg
     4861 tataaaggtt aaaatgccat tcttttgggt caaatatcag attgaaacca gcgtgactga
     4921 ctaaataatc atctagttga taagctattt gtaatttcaa atcctgcaac aattctttta
     4981 ctgcgaaaaa cacttctaaa ttttgaattg agaaaggagc ttgttctccc agtaaataat
     5041 aagcatcatg attacctata agattaatta catctattcc gttttgctct ttatctattt
     5101 tccaagagta taaaaaagtg aggtctttgg cataaagttg gatattgtta gtttgaccat
     5161 gtaaatcaac ataatcacca agaaaaatga ttctcttaat gttatgtgtt tggataattt
     5221 tgtcaacaat gggtaaaatt agttgagatt ttaaatgtaa gtcaccaatt aataatgtct
     5281 tcatatatat tcccctcttt atttttgata ttagtctaag aatagaatta agctctatca
     5341 aattttttag gcaatagaga agtgtttttt gaatattgat aggatttttt aactgtatca
     5401 tagcagataa caggtattgt tttgctattt tttacatctc catcaataaa gtaatgactt
     5461 ttactatcat ggtaaatctt acctaggtaa cttttatctt tagctacttc ccaagaagca
     5521 aaatgcccag agataatatc tttataaaat ctaccagttg taataggaaa tttgttggta
     5581 aatatctctg gactcgttag gtctttccaa agattattag cttcttcatc aatgccagca
     5641 tggacaaaaa tttgattttc tgtttcaaaa taacgactat cttcatatcg tttttggaac
     5701 cagtttataa atggaatata cttatcatta tttctaattt cgtttctaac acctgtttca
     5761 aagttgttag gatttgtttt taaaatatag ttcaattcct ctgtagagaa gaaactcttt
     5821 attgtttctg gaaacgcaga agcagtagga ttatctaaaa tcaaccaatc ataaaaccat
     5881 tcttcatgat ttccaaaaag tgtaataatt tgttttggat aaatcttttc aagttcaatt
     5941 attttagaaa tgacttgaaa agattgagaa ccgtaatcaa tatagtctcc aagtaagata
     6001 agtttacttt gtttatcaga taaatctatt ttattgagag atttaataaa ctcattgtag
     6061 tgcccatgta tatcagatac ggaataataa attgccatat aagattcttt ctataatcaa
     6121 cgtgaattta cagcgtatat gtaatttata taattagcaa aatcacccat acgttttcta
     6181 tcgttatgaa acttatcgaa ccaagaggta tctttgttat tgatttgagc caagcctcta
     6241 atagatataa ggttatctct aattctatta tgaatattag ttcttgtatc atcaagtgta
     6301 tcttgctctt cttttgtaag tattcgccat tttcctctca tttcagcata cttcgcactg
     6361 tactcgataa gttctttcca gtatgcttga aattcagggt cataaatgtt tgatgatttt
     6421 ataagttcat ctaaaattat ttcagcttgt tcaaaagtta cgatttcttt gtcttttaga
     6481 aaatcgttat aagtaaaaat ttgcatagta agctccttta atttttgaaa taattataac
     6541 acattattta gtaattagaa ttacattaga acaagaaaac cataaatttc cattgtattg
     6601 acctacgttt aaatctttta gagtaacagg acaggtttta ttatttgcca tttcttgaac
     6661 agaagcagta ggggataatg tatttacttt gacttgtatc atctccataa agaaatcaga
     6721 atcctcatct tgaattgaca cgttaagtcg taaagctacg ggcttattag tctctctgtc
     6781 taatacttct gtatagcctt ttactgctat aaatttgttg ccaagcagtt ctggctttaa
     6841 aaaatcattt agcttcatgt gtacctcttt tctatcatcg cagagcgatg aggaacagat
     6901 atttttgctg aaaatctatt aaatttaagc aaaaatatct gttgaaatta ttttgacttt
     6961 gttacgtata attgtagttc ttttataaaa tcgaattgag ttgtatcaag ataagggctt
     7021 tcccagtatt gggcagattc tttaccagag ccttgtatat aaagatagcc tgaacctttt
     7081 tcttcaatag gttttaactt atcaggagta gccgaaccaa agaccatgtg atagccttca
     7141 ctagaattag caccaagagc aattctcaat cctaaattat ctctgagttc agtacttaaa
     7201 gtagtactag catttacttg ttgggcagac actaggataa aaatgcctga ctgtcttcca
     7261 agtagaatga tttgtttaat cccatccata acttcagtga taatctctct tgatttttta
     7321 tctgaacctg tagcttgaaa tgctcccatt tcatcaaata taagccatac tggcttaaat
     7381 ccatggttag taaaatttga accatactga aagttatcac gcatgacttg atatcgttcc
     7441 tgcatttcct caactacgac tctcacaatg cgagctatat tatttggggt ggttgctacg
     7501 tatttatttc caaagtaatg agacaagcta cctaggtcag agttcttagg gtcagctata
     7561 taaactgttg attgacgttt tagaaattct aaaatcaaaa cagatataag cacggatttc
     7621 ccacttccag ttccacccga tactaaaata tgtgagcatt tgacaggatt ataatttaca
     7681 ccatatccta aatctatatc aaggctatct atctcttgtc tttggctgtg agattgtaga
     7741 actaaccttt ttggttttat gtaatagaaa tgatattcta taaaactagg tcgaataatc
     7801 ttttcctcaa gctctagttc aagcacgtca gaaagtacat catcaagaga ttgaactttt
     7861 ttactaaatt catcgcccgt tataagagct ttgataagaa catgaccttt ttgtctatct
     7921 atctcgtatt ctaatactgc acttctaacg attttttcat agcctgaacc atctttagat
     7981 gtggtataaa gtctgtttgt gtggagtaca taaagtaagc tctcacgtat aataaggtaa
     8041 tgctctaagt catatcgaaa aatttttatt ttcagatgaa ttttatagat aataaatcca
     8101 cctaaaaata tgaagagaat ttgaacaaaa gttggagccc taatattaac aatagtggaa
     8161 aatagaatgc aggcagagat acttagtatc agccagtgca ttatttttaa cttataacag
     8221 gaaattatat tgtttcttgt taaatcagca ctttgtctta atttaaacat attagttaga
     8281 taccttttat tttatctaaa agctctttta aaagttcgta aaaccctaag agcttgattt
     8341 ttgcgaaata atatgttgag ataagtagtg gaatacaccc aaggataagg atagaattcg
     8401 aaaagaaatg tccttgaggg aatataaaaa ttgctatgcc agctaatatc acaaatccta
     8461 aaagaaatag atatgctttt aaattatcac tcatttcatt acctcctcta ataagcaatt
     8521 attttaagga aaactataaa gatatagtcg ccgataaaat agcgtggtcg gggaaaccga
     8581 ctttattttg ataatcagga ttttctaaga atctccaaga ataacacaca ttagaaatag
     8641 gaatgtttcc tataatatgg tctaatttac aatatttcca agagttctcc tcagacggag
     8701 tatgtacagt taaacctgct ttattcattt ctgattttag taatggatag gagtaaaatt
     8761 ctctaggttt accttgatag gaatgagtat catcattctg cttgaaaaag ccattattaa
     8821 agtcacctag aataattgtg ttttcatgaa ttggtaaatt gaagattagc ttgtctagtt
     8881 gtgtttttct gtgtttgaaa tcttcaaaaa cattttcccc tcctatcttg atacgaactc
     8941 caataatgtt taattcttgt ccttcaattg tcactctaac gtgtaaaaag tttggattat
     9001 tatcatcatt atcgatagta atgacttggc aatcattaac taaatcactc tttattgcaa
     9061 taagaatttc atttccaaaa tctatagtac gcacatcttc aaagattgta taaccattag
     9121 tttgaaggct agaacagaat tgagaatgat tatctgtttt tacatactct gtcagacaga
     9181 taatatctga attttgctga gctagttcct gcgcaatcat ttcaggaatt tgttttcctt
     9241 ttcttgaacg tagatttata ttccaagtgg atgctgtaag ttgtatcata aaatttcctc
     9301 ctaaaagtta gtccgcagga ggaggcacct cctcctgcta tccttcgaat ccatcaaaga
     9361 tttctcctag ttcgtcttca tcatagtagc tttccaattc ctcatagaag taatctaagg
     9421 cttcttggtc aaaaaagttc attgctattc ctcctttcag tatttttttg tacattttaa
     9481 ttgtacaaaa ttaaaagaag aaagtcaaca aaaaagtata ctttaatttc caaaatgtac
     9541 aaatttaata aaaaaaagaa tgagtctggg acaaaaagat tttgatttta ggaattcttt
     9601 attataaatt ttaaaaatcg atagattata caaaaaagcg aacaagacag aattctgagt
     9661 atcagataac tcgttttgtt cgctttttat atttaagatt agacttttgt tccagactca
     9721 ttttataaaa ttatttttga aattccatat ggtatcagaa agtaatttgt ggttgactgg
     9781 tgcaacgatt tcaagaagct gtttttctag aatagagaat ttcttgtcaa aatctttttc
     9841 aggttctgaa atatcgtgat ttaattgggt catcaattct gctttaagaa gaaatttaac
     9901 acatacacct aaagttacac tttgagtatt tgtggcacta ggcaatattt ctttatattt
     9961 tttaattcct tctgctactt catcggacag tgcaacgttc aattttaatt ccttttcttc
    10021 cactggataa atatttttta aagagataga gttatcttgt acaacttttg tccagtttgt
    10081 tacagtcttt gaattttgaa acgcacgcgt taaaatggta gctttagtta tattgatacc
    10141 ttctgaagtt tcatatttct cttttagcat tcttaaatag taagctgctt caccagatat
    10201 tcggacttga aattgtgtca ttattagtac ctccgtattg tattatacca tttgtacatt
    10261 aaaaggacaa tgtataaacg aataatctac cttctcgttc aagcattttt acaagtttag
    10321 taatcttgtt gaagatgcat tccatgtgtt acgtttaaaa aagggaatta aagtaatcta
    10381 gttcctaaaa ggttactaaa aataaaaaaa ctatcgtttt tgtgatagag gtaacttttt
    10441 gaaaaggcta tttgactggc tttatatact tatgaaatgt taagagccc
//
LOCUS       DBMVGT010000059        10460 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.059, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000059 DBMVGT010000000
VERSION     DBMVGT010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10460)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10460)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10460
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.059"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..132
                     /locus_tag="AC0DU4_001655"
     CDS             <1..132
                     /locus_tag="AC0DU4_001655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA-dihydrouridine synthase"
                     /protein_id="HIN4237582.1"
                     /translation="VREFRGLAPHYLRGTSGAAKLRGAISQASTLAEIEALLQLEKA"
     gene            complement(362..2965)
                     /locus_tag="AC0DU4_001656"
     CDS             complement(362..2965)
                     /locus_tag="AC0DU4_001656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RICH domain-containing protein"
                     /protein_id="HIN4237583.1"
                     /translation="MFASKSERKVHYSIRKFSIGVASVVVASLFLGGVVHAEGVRSKN
                     NLTVTSSGQDISKKYADEVESHLQSILKDVNKNLKKVQHTQNVDFNKKLSRIKTKYLY
                     GLKEKSEAELTLKTKETKEELTAAFEQFKKDTLKSGKKVAEAEKKAKAQKEEDRRNYP
                     TNTYKTIELEIAEAEVGVAKAELELEFAQAQVQIPQDTEKINAAKSKVEAAKSNVKKL
                     EKIKSDIEKTYLYKLDNSTKETPKSRVRRNSPQVGDSRELKETIDKAKETLSTYMVTR
                     LTKLDPSVFWFADLLMDAKKVVEEYKTKLEDASDKKSVEDLRKEAEGKIESLIVTHQN
                     REKENQPAPQPGGQAGGSMVVPPVTQTPPSTSQSPGQKATEAEKKKLQDLIRQFQEAL
                     NKLDDETKTVPDGAKLTGEAGKAYNETRTYAKEVVDKSKKLLSQTAVTMDELAMQLTK
                     LNDAMSKLKEAKAKLVPEVKPQPENPEPKPQPEGEKPSVPDINQEKEKAKLAIATYMS
                     KILDDIKKHHLKKEKHHQIVALIKDLDKLKKQALSEIDNVNTKVEIENTVHKVFADMD
                     TVVTKFQKGLIQNTPQVPEAPKSPEVPKVSDTPKAPDTPQVPEAPKSPEVPKVPEAPK
                     APDTPQVPEAPKSPEVPKVPDTPKAPDTPQVPEAPKSPEVPKVPDTPKAPDTPQVPEA
                     PKAPDTPQIPEAPAPETPAPAPEAPKTGWKQENGMWYFYNTDGSMATGWLEYNGSWYY
                     LNANGAMATGWLEYNGSWYYLNTNGAMETGWLEYNGSWYYLNTNGAMETGWLEYNGSW
                     YYLNANGSMATGWLKDGDTWYYLEASGAMKESQWFKVSDKWYYVNGSGALAVNTTVGG
                     YRVNANGKWVN"
     gene            complement(3044..3571)
                     /locus_tag="AC0DU4_001657"
     CDS             complement(3044..3571)
                     /locus_tag="AC0DU4_001657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenylcysteine carboxyl methyltransferase
                     family protein"
                     /protein_id="HIN4237584.1"
                     /translation="MVLAIILVTFFIRLIFLKRSIENEKRILSNGGKEFGVENTKRLT
                     MAHIVFYLSCLVEAMVHKTIFDGMGMVGLVLLIFSMLMLMLVIHLLGDIWTVKLMLVN
                     NHKYVDHILFRTVKHPNYFLNILPELIGLTLLSHAYMTFVLVFPVYAVILYRRIAEEE
                     KLLHEVIIPNGSIKR"
     gene            complement(3654..4985)
                     /gene="hk06"
                     /locus_tag="AC0DU4_001658"
     CDS             complement(3654..4985)
                     /gene="hk06"
                     /locus_tag="AC0DU4_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     HK06"
                     /protein_id="HIN4237585.1"
                     /translation="MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGE
                     KFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLKRDIVDKRLPLVHDLDIKDG
                     KLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFS
                     YFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGKQINGMYEHLLKVIYE
                     LESRNEQIVKLQNQKVSFVRGASHELKTPLASLRIILENMQHNIGDYKDHPKYIAKSI
                     NKIDQMSHLLEEVLESSKFQEWTECRETLTVKPVLVDILSRYQELAHSIGVTIENQLT
                     DATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQELEH
                     LFDIFYHSQIVTDKDESSGLGLYIVNNILESYQMDYSFLPYEHGMEFKISL"
     gene            complement(4982..5635)
                     /gene="rr06"
                     /locus_tag="AC0DU4_001659"
     CDS             complement(4982..5635)
                     /gene="rr06"
                     /locus_tag="AC0DU4_001659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001024075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RR06"
                     /protein_id="HIN4237586.1"
                     /translation="MNILVADDEEMIREGIAAFLTEEGYHVIMAKDGQEVLEKFQDLP
                     IHLMVLDLMMPRKSGFEVLKEINQKHDIPVIVLSALGDEITQSQVFDLYADDHVTKPF
                     SLVLLVKRIKALIRRYYVIEDIWRYQDVTVDFTSYKAHYKNEEIDLKPKELLVLKCLI
                     QHKNQVLSREQILEEISKDVADLPCDRVVDVYIRTLRKKLALDCIVTVKNVGYKISL"
     gene            complement(5956..8388)
                     /locus_tag="AC0DU4_001660"
     CDS             complement(5956..8388)
                     /locus_tag="AC0DU4_001660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001109706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HIN4237587.1"
                     /translation="MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAG
                     ATLNDYPYEMDRLEEVALELTETDYSQDETFTELPFSRRLQVLFDEAEYVASVVHAKV
                     LGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
                     LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRM
                     IQILSRKTKNNPVLVGDAGVGKTALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAG
                     TRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDSTLDAANILKPALARG
                     TLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQ
                     ITDEAVETAVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSDLSPADKAL
                     MDGKWKQAAQLIAKEEEVPVYKDLVTESDILTTLSRLSGIPVQKLTQTDAKKYLNLEA
                     ELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAKALAEVL
                     FDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVE
                     KAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDI
                     RFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSSDHMQEVVKIMVKPLVASLAE
                     KGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSTLKI
                     GVKAGQLKFDIA"
     gene            complement(8390..8848)
                     /locus_tag="AC0DU4_001661"
     CDS             complement(8390..8848)
                     /locus_tag="AC0DU4_001661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HIN4237588.1"
                     /translation="MRFKNTSDHIEAYIKAILDQSGIVELQRSQLADTFQVVPSQINY
                     VIKTRFTESRGYLVESKRGGGGYIRIGRIEFSSHHEMLRDLLYSIGERVSQEIYEDIL
                     QLLVEQELMTKQEMNLLESVALDRVLGEEAPVVRANMLRQVIQEVDRKGK"
     gene            complement(8971..9696)
                     /locus_tag="AC0DU4_001662"
     CDS             complement(8971..9696)
                     /locus_tag="AC0DU4_001662"
                     /EC_number="7.6.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005215 - transporter activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237589.1"
                     /translation="MTEIRLEHVSYAYGQERILEDINLRVTSGEVVSILGPSGVGKTT
                     LFNLIAGILEVQSGRIVLDGEENPKGRVSYMLQKDLLLEHKTVLGNIILPLLIQKVDK
                     AEAISRADKILATFQLTAVRDKYPHELSGGMRQRVALLRTYLFGHKLFLLDEAFSALD
                     EMTKMELHAWYLEIHKQLQLTTLIITHSIEEALNLSDRIYILKNRPGQIVSEIKLDWS
                     EDEDKEVQKIAYKRQILAELGLE"
     gene            complement(9696..>10460)
                     /locus_tag="AC0DU4_001663"
     CDS             complement(9696..>10460)
                     /locus_tag="AC0DU4_001663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004239662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4237590.1"
                     /translation="SDLVINGKAPFAVYFQDYMAKKLEKGAGITAVAAIVEHNTSGII
                     SRKSDNVSSPKDLVGKKYGTWNDPTELAMLKTLVESQGGDFEKVEKVPNNDSNSITPI
                     ANGVFDTAWIYYGWDGILAKSQGVDANFMYLKDYVKEFDYYSPVIIANNDYLKDNKEE
                     ARKVIQAIKKGYQYAMEHPEEAADILIKNAPELKEKRDFVIESQKYLSKEYASDKEKW
                     GQFDAARWNAFYKWDKENGILKEDLTDKGFTNEFVK"
BASE COUNT         2788 a         2397 c         1842 g         3433 t
ORIGIN      
        1 gttcgtgaat tccgcggcct cgctcctcac tatctccgtg gaacatctgg cgctgccaaa
       61 ctccgtggag ccatttcaca agctagcacc ctggcagaga ttgaagctct cttgcaattg
      121 gagaaggctt aatagtttaa aacccgtaac tctcttaaag agtctcttga gtgccgccat
      181 tctttcctca tcaaaaaaac tccgtagtct ctagcgccat aaatccggct agagattaca
      241 gagttatttt ttaatctaaa cttcctacaa gggtatagta tctactgaaa ggatatggta
      301 tttgtaggga atactttaaa gagttcttac aggaagccag cattaacgag ttacattagg
      361 tttagtttac ccatttacca ttggcattga ctctatagcc acctacagtt gtgttgactg
      421 caagggcacc tgagccattg acatagtacc atttgtctga tactttgaac cattggcttt
      481 ctttcatagc ccctgatgct tcaagatagt accatgtatc tccatctttc agccaacctg
      541 ttgccatcga accgttagca tttaggtagt accatgaacc attgtattct agccaacctg
      601 tctccatagc accattagta ttgaggtagt accatgaacc attgtattct agccaacctg
      661 tctccatagc accattagta ttgaggtagt accatgaacc attgtattct agccaacctg
      721 ttgccatagc accattagcg ttgagatagt accatgagcc attgtattct agccagcctg
      781 ttgccattga accatcagta ttgtagaagt accacatacc gttttcttgt ttccagcctg
      841 tttttggagc ttctggagct ggagccggag tttctggagc tggtgcttcc ggaatttgcg
      901 gtgtgtctgg agcctttggt gcttctggaa cctgcggtgt gtccggagcc tttggtgtat
      961 ctggaacctt tggtacctct gggctctttg gtgcttctgg aacttgcggt gtgtccggag
     1021 cctttggtgt atctggaacc tttggtacct ctgggctctt tggtgcttcc ggaacttgcg
     1081 gtgtgtctgg agcctttggt gcttctggaa cctttggtac ctctgggctc tttggtgctt
     1141 ctggaacctg cggtgtgtcc ggagcctttg gtgtatctga aacctttggt acctctgggc
     1201 tctttggtgc ttctggaacc tgcggtgtgt tctgaattaa gcctttttgg aatttagtaa
     1261 caaccgtatc catgtctgca aataccttgt ggactgtatt ctcaatttct actttggtat
     1321 ttacattatc aatttcagaa agtgcttgct ttttaagttt atcaaggtcc ttaataagag
     1381 caacaatctg atgatgtttt tctttcttca gatgatgttt ctttatatca tctaaaatct
     1441 tgctcatgta tgttgctata gcaagtttag ctttttcttt ctcctgatta atatctggta
     1501 cgcttggttt ctcaccctct ggttgtggtt ttggctctgg gttttccggc tgtggtttaa
     1561 cctctggtac caatttcgct ttagcttctt tcaatttaga catggcatcg ttcaatttgg
     1621 ttaattgcat tgccaattca tccattgtca ctgctgtctg tgatagaagc ttcttgcttt
     1681 tgtcaacaac ttctttcgca taagttctag tctcattata ggcttttcca gcttctcctg
     1741 tgagtttagc cccatctgga acagtctttg tttcatcgtc tagtttgttc aaggcttctt
     1801 ggaattgacg aatcaagtct tgtaactttt tcttttcagc ttcggtcgcc ttttgtcctg
     1861 gactttggga agttgatgga ggtgtttgcg tcaccggtgg tacaaccatt gaaccacctg
     1921 cttgtcctcc tggttggggt gctggttggt tttctttttc tctattttgg tgagtcacga
     1981 taagagactc tatttttcct tctgcttcct ttcgcaagtc ttctaccgat tttttatctg
     2041 aagcatcctc taattttgtc ttgtattctt ccacaacctt cttagcatcc ataagaagat
     2101 ctgcaaacca aaaaacagat ggatccagct tcgttaaacg agttaccata taggtagaca
     2161 gagtttcttt cgctttgtct atcgtttcct taagttctct cgaatcgcct acttgcggag
     2221 aatttcttcg cactctagat tttggcgttt ctttggttga gttatctaat ttatacaaat
     2281 acgttttttc aatatctgat ttaatttttt ctagtttttt aacattactt ttagcagctt
     2341 ctactttaga tttagcagca ttaattttct cagtatcttg aggtatttga acttgagctt
     2401 gtgcaaactc aagctcaagc tctgccttgg cgacccctac ttctgcttcc gcaatttcca
     2461 gttcgattgt tttgtaagta ttggttgggt agttacggcg atcttcttct ttttgagctt
     2521 tggctttttt ctcagcttct gctacctttt ttcctgattt caatgtatct tttttaaact
     2581 gctcaaaagc tgcggttaac tcttcttttg tttcttttgt ttttaacgtc aactcagctt
     2641 ccgacttctc ttttaatcca tacaaatact tcgttttaat tctgctcaac tttttgttga
     2701 agtcgacatt ttgggtatgt tgaacttttt tcaaattttt attgacatcc ttcaatatac
     2761 tttgtagatg cgactcgact tcatcagcat acttcttcga tatatcttgc ccactagatg
     2821 taaccgtgag gttattctta ctcctaaccc cttctgcatg gactactcct cctaagaaca
     2881 agctggcaac tactacacta gctactccaa tactaaattt acgaattgaa taatgtactt
     2941 ttctttcgct ttttgatgca aacatgttta tttccttcta tattttttct ttaaccttac
     3001 tatatcactt caatatgaac tgtatatgag tcgaattttg tatttatctc tttatgcttc
     3061 catttgggat tataacttca tgtaatagct tttcctcttc agctattcgt cgatacaaaa
     3121 taactgcata aactggaaaa actaaaacaa aagtcatata ggcatgactc aacaaggtca
     3181 agccaatcaa ctcaggtaaa atatttaaaa agtaattagg gtgttttact gtcctaaaca
     3241 agatatgatc tacatatttg tgattattga caagcataag cttcactgtc caaatatctc
     3301 ccaacaagtg aatcaccaac atcaacatca gcatagaaaa aataagcaag actaaaccaa
     3361 ccatgcccat gccatcaaaa attgtcttgt gcaccattgc ctcaaccaag caagagagat
     3421 aaaaaacaat atgagccata gttaatcgtt ttgtattctc aactccaaat tctttcccgc
     3481 cattgctaag gattcgtttc tcattctcta tcgaacgctt taaaaaaatc aatcgaataa
     3541 agaatgttac taaaataatc gctaatacca tattagtatc ctttctttta tctacacaaa
     3601 gaataacaca cttatgttaa ccctatatga actttaataa aaaactaatc tgtctacaag
     3661 ctaatcttaa attccatacc gtgttcataa gggagaaaac tataatccat ttgatagctt
     3721 tctaaaatat tattcacaat gtaaagaccc aaaccggaac tttcatcctt atctgtcacg
     3781 atttgagaat gataaaatat atcaaataaa tgttctagtt cttggtcact tagaggcgca
     3841 catgtatttt tgatagagag atagccatct tgctcggata tgattacgcg cccattttta
     3901 tctgaatatt taattgcatt actaatcagg tttgtcaaaa ccttatccaa tgccctaaga
     3961 ctcatgacga ctctggtagc atctgtcaat tgattttcaa ttgtaacacc tattgaatga
     4021 gctaattctt gataacgtga taaaatatct actaaaactg gcttaacagt caaagtctca
     4081 cgacactctg tccactcttg gaatttagaa gactccagta cttcttccaa taagtggctc
     4141 atctggtcaa tcttatttat actctttgca atatattttg gatgatcttt gtaatctcca
     4201 atattatgct gcatattctc taggataatt ctaagactgg ctaaaggggt tttcaactca
     4261 tgtgatgctc cgcggacaaa ggaaaccttt tgattttgca attttacaat ttgctcatta
     4321 cgactttcca actcataaat aaccttcaac aagtgctcat acataccatt aatctgtttt
     4381 ccaacttcac caacttcatc tttcctactt tcatcaaaac gaatattgtc atccaaatct
     4441 tgcattttac tagtcacttc tgaaatgtaa aaaagaggat tgagcaagcg tttagtataa
     4501 aaataagaaa aaacaaagga aaaagcaatt gtaaccaaaa atgtatatgg gagatacaaa
     4561 agcaaaatat tctttgcttc tttgtagaca tccaccccgt gaacaaattg cactgttacc
     4621 tgtttaccat ctgctgtact aacagacata tctaacatca cgatataatt tgatagcttt
     4681 ccatctttaa tatccaagtc atgcacaaga gggagccgct tatctacaat atctctttta
     4741 aggtgagcag atatggtcaa ggactttgaa taagactgga gtaagcttgg aatttcatca
     4801 gatgtcttag tctttaaata ctccgtaaac actcttgcgc tctcattaaa cttttccccc
     4861 tccagttgaa tataataaaa aggaaaggtc aaataaatag ctatatgaat gactagacca
     4921 acaccaccta gaattgcaaa acttcttaaa aaggacttgg ttaataattt aggatttttt
     4981 atcataaact aatcttatac ccaacatttt tcacagtcac gatacaatct aaagctaatt
     5041 ttttgcgaag agtacgaata tagacatcaa cgaccctatc acaaggtaaa tcagctacat
     5101 cttttgaaat ttcttccaat atctgctctc tacttaaaac ttgattttta tgctgaatca
     5161 aacactttag taccagtaat tcctttggtt tgagatcaat ttcttcattt ttataatgtg
     5221 ctttgtaaga ggtaaaatcc actgttacat cctgatatcg ccaaatatcc tctatgacgt
     5281 agtaacgtct gataagcgcc ttaatacgct tgacaagcag taccaaagaa aaaggttttg
     5341 tcacatgatc atcagcatag agatcaaata cctgtgactg agtaatttca tctcccagag
     5401 cactcaagac gatgacagga atatcgtgct tttgattgat ttcttttaac acttcaaaac
     5461 cactcttcct aggcatcatt aaatccagta ccatgagatg gatagggaga tcttgaaatt
     5521 tttccaagac ctcttgtcca tccttagcca taatgacatg ataaccctct tctgtcagaa
     5581 atgctgcaat tccttctcta atcatttcct cgtcatctgc aactaaaatg ttcatctctc
     5641 tccctttcta ctaccagaac tccatacatc tatttcctgt atgctatttg aaaatttcct
     5701 accagcctat catctatgat aatagaatgg atttcattta tccgctactt tttgtcaaca
     5761 acaacgtcaa tacaagaaaa tcattcatct tgcagcttat actcttcgaa aatctcttca
     5821 aaccacgtca gctctatctg caacctcaaa acagtgtttt gagcaacctg cggctagctg
     5881 cctagtttgc tctttgattt tcattgagtt tcactccact gtgacttatg gtcagatgct
     5941 ggtactttta ttcttttatg caatatcaaa ttttaactgg cctgctttga caccaatctt
     6001 aagtgtgctg cctgccacta aatctccctt gagaagaagt tctgccaact tgtcctccac
     6061 ttctgtttgc agggttctgc gaagtgggcg agctcccatc tctgggtcat atccttgatt
     6121 tgctaacaat ttcagagctg aagcttgtaa tttcaagtca atgccttttt cagccaaact
     6181 tgccactaaa ggcttgacca taatcttcac cacttcctgc atatgatcac tagataggct
     6241 atggaagacc accttctcat caatacggtt gatgaattcc ggtctataag cttttttcag
     6301 ttcttcaaac atgcgttttt ccatattttc ctggtcaaaa cgaatatcct tagccccaaa
     6361 accaacagtc ttatcatcac gaagggcagt cgcacctagg ttcgatgtca taatgataat
     6421 ggtatttgaa aaatcgacct tgcgtccctt gctatctgtc aagacaccgt catccagaac
     6481 ctgcaagaga acattaaaga tatctgggtg agccttctct acctcatcaa agaggagaac
     6541 ggaatagggt ttattgcgaa ccttctctgt caactcccca ccttcttcgt aacccacata
     6601 gcctggagga gctccattta gacggctggc tgcgaatttc tccatatact cactcatatc
     6661 aaagcggata agggctgatt cgtcatcaaa gagaacttct gccaaagcct tggccaactc
     6721 ggtcttaccg acacctgtgg gtcctaggaa cataaaggaa ccgatcggac gcttgtgact
     6781 gcgaattcct gactgattac ggcgaatcgc acgactaata cttgaaacag cttgatcttg
     6841 accgataacc cgtttatgga gttctgcttc aagatttaga tatttcttag cgtcagtctg
     6901 agtcagcttt tgaactggga ttcctgacaa gcgactcaag gtggtcaaaa tatcagactc
     6961 tgtcaccaag tctttgtaga caggtacttc ctcttctttt gcgattagct gggctgcctg
     7021 tttccacttg ccatccatca gggccttgtc agctggactc aaatctgaat cgtctgcttt
     7081 tacatgcttt gccttatttt gcactgttgc tgctgcttcg tccaagaggt cgatagcaga
     7141 gtctggcaag tgacgactgg ttaaataacg atgagccatc ttaaccgctg tttcaaccgc
     7201 ttcatctgtg atttgtacac ggtgatgttt ctcataagtc gccttcaaac cttgtaaaat
     7261 agtcatacta tctgccacac ttggttcttc aatcgtcact ttagcgaaac gacgagaaag
     7321 tgccgcatct ttttcgatat gtttttgata ttcttcctga gtagtggcac caaccgttct
     7381 caaagttcca cgcgccaagg ctggtttcaa gatattggcc gcatccagag tcgaatcaat
     7441 cccgctacca gaacccatga tggtgtgaag ttcatcgata aagaggatga cttggccatc
     7501 ttcttcaata tccttgatga tattattcat gcgttcttca aagtcaccac ggaagcgtgt
     7561 ccctgcaacg acattcatca aatcaagttc taacacgcgc atcttagcca tttccgcagg
     7621 cacgtcacca ctagcaatac gctgggcaag accaagggcc agagctgttt tcccgacacc
     7681 agcatcccca accaagacag ggttgttctt agtcttacgg ctcaagattt gaatcatacg
     7741 tgagatttcc ttgtcccgac cgatgactgg ttctaacttg ccagaacgcg cttgctctgt
     7801 caaatcatgc gtatagtcct cgagaccacc actaggagtc tgcggcatgc ccatcatatt
     7861 ggccatagaa ttttgcttgt cagctactgt acgatggcgt tggcgtaaag ccttgagatc
     7921 ttcacgagtc cagcctgcac gttcttctaa atttcgacga agggcagcaa tcttgacctg
     7981 atctttcttg tcttcataag aaaaaccagc cctctccaag atacgagtcg ccaaggcatt
     8041 gccatcatgc aaaatcgcat agaggacgtg ctctgtccct agtaccttag catggaccac
     8101 tgacgctaca tactctgctt catcaaaaag aacctgcaaa cgacgggaga acggcaattc
     8161 cgtaaaggtt tcatcctggc tatagtccgt ttcagtcagt tccaaagcca cctcttctaa
     8221 acggtccatc tcatacggat aatcatttaa agttgcccct gctacactat aactgtgatt
     8281 agacatggca atcaacaagt gccacgactc tagataacga gctccaaaat gtccagcaac
     8341 catgtaggca ctttcgatac attcattcaa tgcttttgaa tagttcatct tacttccctt
     8401 ttctatctac ctcttgtatg acctgacgta gcatgtttgc tcgaacaact ggagcttctt
     8461 ctcctaaaac gcgatccaaa gctactgatt ctagcaaatt catctcctgc ttggtcatca
     8521 attcctgctc aaccaaaagc tggagaatat cctcataaat ttcttgactg actcgctcac
     8581 caatcgagta aagcagatcc cggagcattt catgatgact agaaaactca atccgtccta
     8641 tacgaatgta gcctccgcca ccacgcttac tttcaaccaa gtagcctcta ctttccgtaa
     8701 agcgtgtctt gatcacgtag ttaatctgac taggaacaac ctgaaaggta tctgccaact
     8761 gactccgttg caactccacg ataccagatt gatctaaaat cgccttgatg taggcctcaa
     8821 tatgatccga tgtattttta aatctcataa caaacccacc tctctcttta aaccttgacc
     8881 ttgtttgact attataccga aattttctca tttttaaaag aaaaagggcg ctggtaaagg
     8941 ataatcttca ccaactccct atttttctac ttattctaag cctaattctg ccaagatttg
     9001 acgtttgtag gcaatctttt ggacttcctt gtcctcatct tcagaccaat ctagtttaat
     9061 ttctgaaaca atctgcccag ggcgattttt caagatatag atgcggtcgc tgagattgag
     9121 ggcctcctca atactatgcg tgatgatcag agttgttagc tgcaactgtt tgtgaatctc
     9181 aagataccaa gcgtggagtt ccatctttgt catctcatcc aaggcgctaa aggcctcatc
     9241 taagagaaag agcttgtgcc caaaaaggta ggtccggagt aaggctacac gctggcgcat
     9301 cccaccgcta agttcatgag gatacttgtc tcttacagct gtcagctgga aggtcgcaag
     9361 aattttatcc gctcgggaaa tagcttctgc cttatccacc ttttgaatca agaggggcag
     9421 aatgatattt ccaagcaccg tcttgtgctc caagagcaga tccttttgca acatataact
     9481 cacgcgcccc ttgggatttt cttcaccatc aaggacaatt ctccctgact gaacttctaa
     9541 aatcccagcg attagattaa agagggtggt ctttccaaca ccacttgggc ctaggatgga
     9601 aaccacttcg cctgaagtca cccgtagatt gatatcctct aaaatcctct cctgaccata
     9661 ggcataactg acgtgctcta gtctaatttc tgtcattatt tcacaaattc gttggtgaag
     9721 cctttgtctg tcaagtcttc tttaaggata ccattttctt tatcccattt gtagaaagca
     9781 ttccagcgag ctgcgtcaaa ttgaccccat ttttccttgt cgcttgcgta ttcttttgac
     9841 aagtattttt gagattcgat gacaaagtca cgtttttcct tgagttcagg tgcattcttg
     9901 atgagaatat ctgcagcttc ttctggatgt tccatggcat attggtagcc ttttttgatg
     9961 gcttggatga ctttgcgagc ttcttctttg ttatctttca gatagtcgtt gtttgcgatg
    10021 ataactggtg aatagtagtc aaactccttg acatagtctt tcaagtacat gaagttagca
    10081 tctacacctt gagatttagc aaggatacca tcccaaccgt agtaaatcca agcagtatca
    10141 aagacgccat tggcaatcgg tgtgattgag tttgagtcgt tatttggtac tttttcaacc
    10201 ttctcaaagt ctccaccttg agattctacc aaggttttca acatagcaag ttcagttggg
    10261 tcattccatg tcccatattt cttaccaacc aagtcttttg gactgcttac attatcagat
    10321 ttacgagaga tgattcctga tgtattgtgt tcaacaatag ctgcaacggc agtgattcct
    10381 gctccttttt ccaatttctt agccatgtag tcttggaaat acactgcaaa tggtgccttt
    10441 ccgttgataa ccaagtcaga
//
LOCUS       DBMVGT010000060        10169 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.060, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000060 DBMVGT010000000
VERSION     DBMVGT010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10169)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10169)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10169
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.060"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(11..457)
                     /gene="rplM"
                     /locus_tag="AC0DU4_001664"
     CDS             complement(11..457)
                     /gene="rplM"
                     /locus_tag="AC0DU4_001664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HIN4237591.1"
                     /translation="MNKTTFMAKPGQVERKWYVVDATDVPLGRLSAVVASVLRGKNKP
                     TFTPHTDTGDFVIVINAEKVKLTGKKATDKIYYTHSNHPGGLKQISAGELRSKNAVRL
                     IEKSVKGMLPHNTLGRAQGMKLKVFVGAEHTHAAQQPEVLDISGLI"
     gene            814..1131
                     /locus_tag="AC0DU4_001665"
     CDS             814..1131
                     /locus_tag="AC0DU4_001665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF960 domain-containing protein"
                     /protein_id="HIN4237592.1"
                     /translation="MAFTNTHMRSASFGIVTSLPDDIIDSFWYIIDHFLKNVFELEEE
                     LEFQLLNNQGKITFHFSSQHLPTAIDFDFNHPFDPRYPPRVLVLDMDGRETILLPEEN
                     DLF"
     gene            complement(1281..2093)
                     /gene="folK"
                     /locus_tag="AC0DU4_001666"
     CDS             complement(1281..2093)
                     /gene="folK"
                     /locus_tag="AC0DU4_001666"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003848 -
                     2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
                     diphosphokinase activity [Evidence IEA];
                     GO_process: GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HIN4237593.1"
                     /translation="MDQLQIKDLEMFAYHGLFPSEKELGQKFVVSAILSYDMTKAATD
                     LDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLVERTFESYPLVQEMKLELKKPWA
                     PVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLAT
                     EPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFV
                     EDQILYTDDLILPHPYIAERLFVLESLQEIAPHFIHPILKQPIRNLYDALKK"
     gene            complement(2136..2690)
                     /gene="folE"
                     /locus_tag="AC0DU4_001667"
     CDS             complement(2136..2690)
                     /gene="folE"
                     /locus_tag="AC0DU4_001667"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA];
                     GO_process: GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HIN4237594.1"
                     /translation="MDTQKIEAAVKMIIEAVGEDANREGLQETPARVARMYQEIFSGL
                     GQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLSKL
                     ARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVIIEAEHMCMSMRGVRKPGTATL
                     TTVARGLFETDKDLRDQAYRLMGL"
     gene            complement(2671..3993)
                     /locus_tag="AC0DU4_001668"
     CDS             complement(2671..3993)
                     /locus_tag="AC0DU4_001668"
                     /EC_number="6.3.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0008841 - dihydrofolate synthase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HIN4237595.1"
                     /translation="MKEIENNQWIANYRTDQPHFGLERMVELLALRGNPHLKLKVLHI
                     GGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQISINGESISEARLEALMADY
                     QSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEVGMGGLLDSTNVCQPILT
                     GITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIAPEALTVIDRIAEGKDSPR
                     LAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLYQIENAGMAIALLDTFCQE
                     DGRELASNDFLGQALEETSWPGRLEIVSRDPLMILDGAHNPHAIKALLVTLQERFADY
                     HKEILFTCIKTKALEDMLDLLGAMPDTELTLTHFADSRATDESVLKEAAKSRNLSYQD
                     WHDFLEQNLTDKKEEKQTVRIVTGSLYFLSQVRAYLMERKNENGYTKD"
     gene            complement(3995..4969)
                     /gene="folP"
                     /locus_tag="AC0DU4_001669"
     CDS             complement(3995..4969)
                     /gene="folP"
                     /locus_tag="AC0DU4_001669"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004156 - dihydropteroate synthase
                     activity [Evidence IEA];
                     GO_process: GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HIN4237596.1"
                     /translation="MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQ
                     ALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDT
                     WKSQVAEAALAAGANLVNDITGLMGDEKMAHVVAEARAQVVIMFNPVMARPQHPSSLI
                     FPHFGFNQTFTVEELADFETLPIEDLMVAFFERALARAAEAGIAPENILLDPGIGFGL
                     TKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEESGFEVNPETELGFRNRDTAS
                     AHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDLKQYK"
     gene            complement(5064..5771)
                     /locus_tag="AC0DU4_001670"
     CDS             complement(5064..5771)
                     /locus_tag="AC0DU4_001670"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
                     /protein_id="HIN4237597.1"
                     /translation="MKEKNMWKELLNRAGWILVFLLAVLLYQVPLVVTSILTLKEVAL
                     LQSGLIVAGLSIVVLALFIMGARKTKLASFNFSFFRAKDLARLGLSYLVIVGSNILGS
                     ILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIVPKKIFRGKE
                     NLGFVVGTIVFALLHQPSNLPSLLIYGGMSTVLSWTAYKTQRLEMSILLHMIVNGIAF
                     CLLALVVIMSRTLGISV"
     gene            complement(5824..7242)
                     /locus_tag="AC0DU4_001671"
     CDS             complement(5824..7242)
                     /locus_tag="AC0DU4_001671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0015851 - nucleobase transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HIN4237598.1"
                     /translation="MDKLFKLKENGTDVRTEVLAGLTTFFAMSYILFVNPQILSQTGM
                     PAQGVFLATIIGAVAGTLMMAFYANLPYAQAPGMGLNAFFTFTVVFGLGYSWQEALAM
                     VFICGIISLIITLTNVRKMIIESIPNALRSAISAGIGVFLAYVGIKNAGLLKFTIDPG
                     NYTVVGEGADKAQATIAANSSAVPGLVSFNNPAVLVALAGLAITIFFVIKGIKGGIIL
                     SILTTTVLAIAVGLVDLSSIDFANNHVGAAFEDLKTIFGAALGSEGLGALVSDTARLP
                     ETLMAILAFSLTDIFDTIGTLIGTGEKVGIVATNGENHQSAKLDKALYSDLIGTTVGA
                     IAGTSNVTTYVESAAGIGAGGRTGLTALVVAICFAISSFFSPLLAIVPTAATAPILII
                     VGIMMLGSLKNIHWDDMSEAVPAFFTSIFMGFSYSITQGIAVGFLTYTLTKLVKGQVK
                     DVHAMIWILDALFILNYISMAL"
     gene            7432..8244
                     /locus_tag="AC0DU4_001672"
     CDS             7432..8244
                     /locus_tag="AC0DU4_001672"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HIN4237599.1"
                     /translation="MTKKIIAVDLDGTLLNSDSQISDFTKRTIKKVAEKGHQVIITTG
                     RPYRMSKDFYRELGLDTPMINFNGSLTHLPDQVWDFEKCLTVDKKYLLDMVQRSEDIQ
                     ADFIAGEYRKKFYITNPNEEIANPKLFGVEAFQPEDQFQPELVTKDPNCILLQTRASD
                     KYALAKEMNAFYQHQLSINTWGGPLNILECTPKGVNKAFALDYLLKIMNRDKKDLIAF
                     GDEHNDTEMLAFAGKGYAMKNANPELLPYADEQISLTNDQDGVAKTLQDLFL"
     gene            8583..9602
                     /gene="adhP"
                     /locus_tag="AC0DU4_001673"
     CDS             8583..9602
                     /gene="adhP"
                     /locus_tag="AC0DU4_001673"
                     /EC_number="1.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase AdhP"
                     /protein_id="HIN4237600.1"
                     /translation="MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHV
                     AHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRET
                     LCRTVKNAGYSVDGGMAEQCIVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKV
                     EPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLALAKEVGADIVINGLEVE
                     DVAGLIKGKTDGGAHSAVVTAVSKVAFNQAVDSVRAGGRVVAVGLPSEMMELSIVKTV
                     LDGIQVIGSLVGTRKDLEEAFQFGAEGLVAPVVQKRPVEDAVAIFDEMEKGQIQGRMV
                     LDFTH"
     gene            9836..>10169
                     /locus_tag="AC0DU4_001674"
     CDS             9836..>10169
                     /locus_tag="AC0DU4_001674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HIN4237601.1"
                     /translation="MSIGIIIASHGEFAAGIHQSGSMIFGEQEKVQVVTFMPNEGPDD
                     LYAKFNNAVAAFDAEDEVLVLADLWSGSPFNQASRVMGENPERKFAIITGLNLPMLIQ
                     AYTERLMDA"
BASE COUNT         3011 a         2279 c         1984 g         2895 t
ORIGIN      
        1 gttcctttcc ttagataagt cctgaaatgt caagaacttc tggttgttgt gcagcatgag
       61 tgtgctcagc tccaacaaat actttcaact tcataccttg agcgcgtcca agtgtattgt
      121 gtggaagcat acctttaact gatttctcaa tcaaacgtac tgcattttta gaacgaagtt
      181 cacctgcaga gatttgtttc aatccacctg ggtggtttga gtgagtgtag tagattttat
      241 cagttgcttt tttaccagtc aatttaactt tttcagcatt gataacaatc acgaagtcac
      301 ctgtatcagt gtgtggtgta aatgttggtt tgttttttcc gcgaagtacg ctagcaacta
      361 ctgcagaaag acgtccaagt ggtacatcag ttgcgtcaac tacgtaccat ttacgttcaa
      421 cttggcctgg tttagccata aatgttgttt tgttcatgat ttctcctata tatagttcga
      481 tttttgttta cggtgatggg tgttccttcc catcgaaaag tatttggaag gttccggggc
      541 ctttcaaatg gggtaaacaa taccgcctac tatcatacca aatttcaccc ctaaaagtca
      601 atagatatga aaaatatttt tcggtaactt ctcaaagtaa ctgaaagtta tataatcaag
      661 ttaatttggg aatttaccta ttaacttcgg tagatttttg ggaatttttt tccttctttt
      721 tccctgtagt taaaatcctt ttcaaaaaat caccttttct tgatttttaa tcctatttgc
      781 tgtatgataa gggaaaagaa aggagacaga gatatggctt ttaccaatac ccacatgcgg
      841 tctgctagtt ttggcattgt taccagcttg cctgatgaca tcattgactc tttttggtat
      901 attatcgacc atttcttaaa aaatgtcttt gaattggaag aagaactcga gtttcaattg
      961 cttaataacc aaggaaagat taccttccac ttttcaagtc aacacctccc tacagccatt
     1021 gattttgact ttaaccatcc tttcgaccct cgttatcccc caagagtact ggttttagac
     1081 atggacggta gagaaactat cctcctccca gaagaaaatg acctatttta atactcaatg
     1141 aaaatcaaag agcaaactag gaagctagcc gcaagctgta cttgagtacg gtaaggcgac
     1201 gctgacgtgg tttgaagaga ttttcgaaga gtataaaaac tctagccttc agttgcaagt
     1261 gactgaaaac tagagttttt ctattttttc aaagcatcat acaagttgcg gatcggttgt
     1321 tttaatatcg gatggataaa atgaggcgca atttcctgta aggactcaag gacaaaaagg
     1381 cgttccgcta tataaggatg aggcaatatg aggtcgtctg tataaaggat ctggtcctcc
     1441 acaaagagca agtccaaatc aatcaaacga ggtccccaat gcacttctct cacccgtccc
     1501 agctctgact caatggctaa caaggtttct aacaagtctt gtgctggtag ccaggtttcc
     1561 acctcaacca cttgattggc aaagctatcc tgctccactc caccccaagg ctccgtcgct
     1621 aagacactgg actctttgag aatatggatg ccacgagctc gcagtttgtc aatggcttgc
     1681 ttcaagtttg cttgcttatc tcccatattg cttcctaggg cgataaaggc tcgttgcttg
     1741 cggcgatgaa tggttaccga gcaagtatct agtgacaaat gcaccggtgc ccaaggtttt
     1801 ttcagttcca acttcatttc ttggacaaga ggataagact caaaggtacg ttccaccagt
     1861 ttataggcta ccgtttcaat caaatcttca ctcgtttcct gaaaccaagt cgtccactgc
     1921 tgacacaatt ctccgtaatg gacagaggct gttaaatcca agtctgtagc tgccttggtc
     1981 atatcatagg ataggatggc tgaaacgaca aatttctgcc ccaattcttt ctcactagga
     2041 aaaagaccat gataggcaaa catttccaaa tccttaatct gcagttgatc cataatgatt
     2101 cctttctaga aaaatccgct tgaaacggat tctttttata gccccattaa acgataagct
     2161 tggtcgcgga ggtccttatc tgtttcaaat agaccacgag ctactgtcgt caaggttgca
     2221 gtgcctggtt ttctaacacc acgcatactc atacacatat gttccgcctc aatgataaca
     2281 aaggctcctt tagcacctag atagtccatc aaggcatcgg ccacttcgat attcaaacgt
     2341 tcttgaattt gtggtttttt cgaataaact tcaaccgtac gggctagctt agacaagcct
     2401 gccacacgac catctggaat gtaggcaatg tgcgctctac cataaaatgg caagaagtgg
     2461 tgttcacaca tggtatggaa aaagatatcc ttttctacca ccatattatc gtcaataatt
     2521 tcaaaggatt ttgacaaatg ttcctctgct gtttgaccaa gacctgaaaa aatctcttga
     2581 tacatacggg ctacacgagc aggtgtttcc tgcaaaccct cgcgattagc gtcctctcct
     2641 acagcctcga taatcatttt tacagctgct tcaatctttt gtgtatccat tctcgttctt
     2701 cctctccatc agataggccc tcacttggct caagaaatac aaggaacctg tgacaatcct
     2761 aactgtttgt ttctcttctt ttttatctgt caaattctgc tctagaaaat catgccaatc
     2821 ttggtagctg agatttctag acttagctgc ctctttcagc acgctttcat ccgtcgcccg
     2881 actatccgca aaatgtgtta gagtaagctc ggtatctggc atggctccca gcaagtccaa
     2941 catatcctcc aaggccttgg ttttgataca agtgaagagg atttccttat gataatccgc
     3001 aaaacgttct tgcaaggtta ccaacaaggc cttgatagca tggggattgt gggctccatc
     3061 caaaatcatc aagggatctc ttgacacgat ttccaaacgc cctggccaac ttgtttcttc
     3121 caaggcttga ccaagaaagt cattgcttgc tagctctcga ccatcttctt gacaaaaagt
     3181 atcaagtaaa gctatggcca tcccagcatt ctctatttgg tacaaaccaa gcaggctagt
     3241 ctggaagcga ccttgtctga cagcacttgt atagtcaaag acttcccctg tcaccacact
     3301 ttcttgatga cgaacctgat aatctgtccc gtaggcaagt ctcggcgaat ctttcccttc
     3361 cgcaatgcgg tcaatcacag tcaaggcttc tggagcaata cgccctgtta ccaagggcat
     3421 cccttgtttg ataatacctg ccttctgctc tgctatggcc tccaaggtgt caccaagtag
     3481 ggccacatga tccaagccaa tagttgtaat tcctgtcaaa atgggctgac agacattggt
     3541 actatccaaa agtccaccca tgccaacttc catgatggcc acatctactt gctctgaggc
     3601 aaagtagtca taggccaggg ctgtgataat ctcaaactcg gttgtgccct gtaaattggc
     3661 gaccgcttct ccctccagca aagactgata gtctgccatg agagcttcta gcctcgcttc
     3721 tgagatcgat tccccattga tgctaatctg gtctgtgtaa tgaatgagat agggcgagct
     3781 aaacacgcca actctcagcc ctagcttttc tagcatcttt ttcaaaaaag caatagtcga
     3841 gcccttgccg ttagtccctc cgatatggag gaccttgagt ttgagatggg gattgccacg
     3901 caaagctaac agttccacca ttcgttccaa gccaaaatgc ggttgatccg tccggtagtt
     3961 agcaatccac tgattgtttt caatttcttt catcttattt atattgcttt aaatctaaat
     4021 tttccgcttc atcagccaga cgaatggcag atgcaatttc aactgccatc ctgtgactag
     4081 ctacgtcatg cacgcgcacc acttctacac cctgtctcgc agcgatacta gttacatgag
     4141 ccgaagccgt gtcccgattt cggaaaccaa gctctgtctc aggattgact tcaaacccac
     4201 tttcttcaag gatattgatg acaaatcgct tgcgcgacac tccgagaaag attggatagc
     4261 ccttctgatg tagtttatcc agatcccgta aaaggaggag attttctttc ttggtcagac
     4321 caaagccaat tcctggatcc aacaggatat tttctggtgc aataccagct tctgccgctc
     4381 tcgctagtgc tcgttcaaag aaagccacca tcaagtcttc gattggcaat gtttcaaagt
     4441 cagctaactc ttctactgta aaagtttgat taaatccaaa atgagggaat atgagcgagc
     4501 tagggtgttg aggtcgcgcc ataactggat taaacatgat gaccacttgc gctctcgctt
     4561 cagctaccac atgagccatt ttttcatcgc ccatgagacc agtgatatca ttaactagat
     4621 tggcaccagc agccaaagca gcctctgcta cttgactctt ccaagtatca atagagatga
     4681 ggacatcact ttccttgcga atcgctttga tcactggaac aacacgctgg atttcctctt
     4741 ctatctcaac atagctactg cccggccgag tcgattctcc gccgatatcg agcatactgg
     4801 ctccttctgc tatcaattta cgagcctgct ggagtgcctg ctcaagagca aaaaattgac
     4861 caccgtccga aaaggagtct ggggttacat tgataattcc gcaaataact gtctttgcat
     4921 gattggcttt acttgacata tcggtcactc cctcaaggat tttcatcata ttatttttct
     4981 attttaccat aaaaagaaaa agatggacac gattgcattc atctttccct agtagaaaga
     5041 ggtcggtttc tacataaaag cttttaaaca gaaattccta atgtccgact cataatcacc
     5101 acaagagcca acaaacagaa agcaatccca ttaacaatca tgtgaagcaa gatcgacatt
     5161 tccaaacgtt gggtcttgta ggccgtccaa gatagaactg tcgacatacc tccataaatc
     5221 aataaagaag gtaaattact tggttgatgc aataaagcaa acacaatcgt accgactaca
     5281 aatcccaagt tctccttgcc tcggaaaatc tttttaggaa caatcccacg gcacaagatt
     5341 tcctcacaaa tcggagcaag caaggctagc aagaagaaac tggaaatcaa cgaactattt
     5401 tgaaccatat cgttaatctg agactggtta gctgttgtcg tctcatttga cagttgcaac
     5461 aagatagaac caagtatatt tgacccgaca ataactaaat aactcaagcc caaacgtgcc
     5521 aaatctttag ctctaaaaaa agaaaaatta aaactagcta acttggtttt acgagctccc
     5581 ataataaata gagccagaac cacaattgaa aggccagcaa ctatcagccc tgactgtagc
     5641 agggctactt cttttaaagt caaaatagag gtaaccacta ggggaacctg atataaaagg
     5701 acggcaagta aaaagaccaa aatccagcct gcacgattca acaattcttt ccacatattt
     5761 ttctctttca tcacctatct cctttgtatt aaaaaagggg ggaaatcccc ctgggtcatt
     5821 ctattataag gccatgctga tgtagttaag gataaacaag gcatccaaaa tccaaatcat
     5881 ggcatgaaca tctttaactt gacctttgac aagcttagtc aaagtgtaag tcaagaaacc
     5941 aactgcaatc ccttgagtga tagagtagct gaatcccata aagatagatg tgaagaaggc
     6001 aggaactgct tcagacatat catcccaatg gatatttttc aagctaccaa gcatcataat
     6061 cccaacgata atcaagattg gagctgtagc cgctgttggt acgatcgcta gaagtgggct
     6121 aaagaagctt gaaatcgcaa aacagatagc tacaaccaag gctgtcaaac cagtacgtcc
     6181 acctgcaccg ataccagcag cagactcaac ataagtcgtt acgtttgaag tacctgcaat
     6241 ggcaccgact gtcgttccaa tcaaatcaga gtaaagagcc ttatccaatt tggctgattg
     6301 gtgattttca ccatttgtcg ctacaatacc aactttttca cctgtaccga tcaaggtacc
     6361 aattgtgtca aaaatatctg tcaatgagaa ggcaagaatg gccatcagag tttcaggcaa
     6421 gcgagctgta tctgaaacca aagctcccaa accttctgaa ccaagagctg caccaaagat
     6481 tgtcttcaaa tcttcaaaag ctgcaccaac atggttatta gcaaaatcga tactagacaa
     6541 atcaaccaaa ccaactgcaa tagcaagaac agttgttgtc aagatagaga gaataattcc
     6601 ccctttaatc cctttgatga caaagaagat agtaatggca agtcctgcaa gagccactaa
     6661 aacagctgga ttattaaagc tgaccaatcc tggaactgct gaagagtttg ctgcaatcgt
     6721 tgcttgagct ttgtcagccc cttctcctac aacagtatag ttgcctggat caatcgtgaa
     6781 tttcaaaagt ccagcattct taatccctac ataggcaagg aagacaccga taccagctga
     6841 aatagctgag cgaagagcat tgggaatcga ttcaatgatc attttacgaa catttgtcaa
     6901 ggtaataatc aatgaaataa tcccacagat gaagaccata gctagggctt cttgccaaga
     6961 ataaccaagc ccgaatacaa ctgtaaaggt aaagaaggca ttgagtccca tacctggcgc
     7021 ttgggcataa ggtaagttag cataaaaagc catcatcaag gtacccgcta ctgcaccaat
     7081 aatcgtcgct aggaagacgc cctgagcagg cattcctgtt tgtgaaagta tttgtgggtt
     7141 tacaaagaga atatagctca ttgcaaagaa agttgttaaa ccagcgagaa cctctgtacg
     7201 aacgtctgta ccgttctctt ttagtttaaa taatttgtcc atcatcaatc tccttttaat
     7261 ttttacgaac aataatagaa ttatatcatt tatcattcac tttttcaatg tatttgtttg
     7321 atttgtttaa gaaattaatc caatttcatt ttttgtttgg aatctgcttt tctgcctgct
     7381 ttctgttata atagaagaca tcttatctga aaacacacta gaaaggtcca tatgacgaaa
     7441 aaaattattg cagttgacct ggatggaacc ctgctcaact cagacagtca aatttctgac
     7501 tttaccaaaa gaaccatcaa aaaagttgct gaaaaaggcc atcaggttat tattacgaca
     7561 ggtcgccctt accgtatgtc aaaagatttt taccgtgaac tgggcttaga cactcctatg
     7621 attaacttca acggatccct tactcattta ccagaccaag tttgggattt tgaaaagtgt
     7681 ttgactgtag acaaaaaata tctgctagat atggttcaac gttcagagga cattcaagcc
     7741 gattttatcg ctggagaata tcgtaaaaaa ttctacatta caaatcccaa tgaagaaatt
     7801 gccaatccca aactatttgg tgtagaagct ttccagcctg aagatcaatt ccagcctgaa
     7861 ttggtgacca aggaccctaa ctgtatcctc ttgcagacca gagccagtga caaatatgcc
     7921 ttggcaaaag aaatgaacgc cttctaccag catcaacttt ctatcaatac ctggggaggt
     7981 ccgctcaata tccttgaatg taccccaaaa ggtgtcaaca aggcctttgc tttggactac
     8041 ttgctcaaga taatgaatcg tgacaaaaaa gatttgattg cctttggaga tgaacacaat
     8101 gataccgaaa tgctcgcttt tgctgggaag ggttatgcca tgaaaaatgc caatccagag
     8161 ctactccctt atgcagatga gcaaatttcc cttaccaacg accaagatgg ggttgccaaa
     8221 accctacaag acttattctt ataacctata ctgatactca atgagaatca aagagcaaac
     8281 taggaagcta gccgtaggtt gctcaaagca ctgctttgag gttgtagatg aagctgacgt
     8341 ggtttgaaga gattttcgaa gagtatgacc agcttgcaag ctggtctttg tgctcttttc
     8401 acagtctcat caaccagtta atcgattgtt ctactttttg tctccaaaac cttggaaaag
     8461 gctttctttt gtgatatact tcacatataa atacaagaga gctcgtcaca ctcgactctg
     8521 ttgacaaaaa atcaatccag tcccgttgtc cctgttctcg gtcaatatca aggaggatag
     8581 ctatgaaagc tgttgttgta aatccagaaa gcactggtgt tgctattgaa gaaaaagtac
     8641 tccgtccact tgaaactggg gaagcacttg tagaagttga atactgtggt gtttgccaca
     8701 ccgacctcca cgttgctcat ggtgactttg gtcaagtccc aggacgtgtt cttgggcacg
     8761 aaggtatcgg tatcgttaaa gagattgctc cagatgtgaa aagccttaaa gtcggtgacc
     8821 gcgtcagcgt tgcttggttc tttgaaggat gtggcacttg cgaatactgt acaactggtc
     8881 gcgaaaccct ttgccgtaca gtgaaaaatg ctggctactc agtagacggt ggtatggctg
     8941 aacaatgtat cgtaactgct gactatgctg tcaaggttcc tgacggactt gatccagccc
     9001 aagcttcttc tatcacatgt gctggagtaa caacctataa agctatcaaa gaagcaaaag
     9061 ttgaaccagg ccaatgggtt gttctttacg gtgctggtgg acttggtaac ctcgctgttc
     9121 aatacgctaa aaaagtattc aatgctcatg ttatcgcagt cgatatcaac aatgacaaac
     9181 ttgcccttgc aaaagaagta ggcgctgaca ttgtgattaa cggcctcgaa gttgaagatg
     9241 tagctggact cattaaagga aaaactgatg gaggagctca ttcagctgtc gtaactgctg
     9301 tgtctaaagt tgccttcaac caggctgttg actccgttcg tgctggtggt cgcgtcgtcg
     9361 ctgttggtct tccttctgaa atgatggaac tcagtatcgt taaaacagtc ctcgatggaa
     9421 tccaagtcat cggttctctt gtcggaactc gtaaagactt agaagaagcc ttccaatttg
     9481 gtgcagaagg tctggtagcc ccagttgttc aaaaacgtcc agtagaagat gctgttgcca
     9541 ttttcgacga aatggaaaaa ggtcaaatcc aaggacgtat ggtactcgac ttcacccact
     9601 aatctaatag aaacctattt taaaagttgg aagcttcttc taactttttt atattaaatt
     9661 tttaaataag aattcaagat tactccttaa aaactcaaca tatcaacata taaaaataaa
     9721 aattttttaa ttttttatga taaatagttg ctttttttat gaaaacggtt tatacttaaa
     9781 cagtcttaaa gttttcttaa atgaaaacta aaacaaaaaa ggaggaatga caataatgag
     9841 tatcggaatc attattgcga gccacggcga atttgctgcg ggtattcatc agtcaggatc
     9901 tatgatcttt ggtgaacaag aaaaggttca agttgtgacc tttatgccaa atgaaggtcc
     9961 tgatgatcta tacgctaagt ttaataacgc tgttgctgca tttgacgcag aagatgaggt
    10021 tctagttttg gctgaccttt ggagtggttc tccatttaac caagctagtc gcgtgatggg
    10081 agaaaatcct gagcgtaagt ttgccatcat cacaggactt aacttaccga tgttgattca
    10141 agcctacaca gagcgcctca tggacgctg
//
LOCUS       DBMVGT010000061        10165 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.061, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000061 DBMVGT010000000
VERSION     DBMVGT010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10165)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10165)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10165
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.061"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(29..1651)
                     /gene="groL"
                     /locus_tag="AC0DU4_001675"
     CDS             complement(29..1651)
                     /gene="groL"
                     /locus_tag="AC0DU4_001675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166362.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0140662 - ATP-dependent protein folding
                     chaperone [Evidence IEA];
                     GO_process: GO:0042026 - protein refolding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HIN4237602.1"
                     /translation="MSKEIKFSSDARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFG
                     SPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREG
                     IKNVTAGANPIGIRRGIETAVAAAVEALKNNAIPVANKEAIAQVAAVSSRSEKVGEYI
                     SEAMEKVGKDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDSEKMVADLENPYI
                     LITDKKISNIQEILPLLESILQSNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKA
                     PGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQAARVTVDKDSTVIVEGA
                     GNPEAISHRVAVIKSQIETTTSEFDREKLQERLAKLSGGVAVIKVGAATETELKEMKL
                     RIEDALNATRAAVEEGIVAGGGTALANVIPAVATLELTGDEATGRNIVLRALEEPVRQ
                     IAHNAGFEGSIVIDRLKNAELGIGFNAATGEWVNMIDQGIIDPVKVSRSALQNAASVA
                     SLILTTEAVVANKPEPVAPAPAMDPSMMGGMM"
     gene            complement(1667..1951)
                     /gene="groES"
                     /locus_tag="AC0DU4_001676"
     CDS             complement(1667..1951)
                     /gene="groES"
                     /locus_tag="AC0DU4_001676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HIN4237603.1"
                     /translation="MLKPLGDRVVLKIEEKEQTVGGFVLAGSAQEKTKTAQVVATGQG
                     VRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE"
     gene            complement(2221..2616)
                     /locus_tag="AC0DU4_001677"
     CDS             complement(2221..2616)
                     /locus_tag="AC0DU4_001677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HIN4237604.1"
                     /translation="MYNKVILIGRLTSTPELHKTNNDKSVARATIAVNRRYKDQNGER
                     EADFVNMVLWGRLAETLASYATKGSLISVDGELRTRRFEKNGQMNYVTEVLVTGFQLL
                     ESRAQRAMRENNAGQDLADLVLEEEELPF"
     gene            complement(2694..3455)
                     /locus_tag="AC0DU4_001678"
     CDS             complement(2694..3455)
                     /locus_tag="AC0DU4_001678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HIN4237605.1"
                     /translation="MAKNVVITGATSGIGEAIARAYLEQGEDVVLTGRRIDRLEILKS
                     EFAVSFPNQTVWTFPLDVTDMVMVKTVCSDILETIGRIDILVNNAGLALDLAPYQDYE
                     ELDMLTMLDTNVKGLMAVTRCFLPAMIKVNQGHIINMGSTAGIYAYAGAAVYSATKAA
                     VKTFSDGLRIDTIATDIKVTTIQPGIVETDFSTVRFHGDKERAASVYQGIEALQAQDI
                     ADTVVYVTSQPRRVQITDMTIMANQQATGFMIHKK"
     gene            complement(3488..4114)
                     /gene="ytpR"
                     /locus_tag="AC0DU4_001679"
     CDS             complement(3488..4114)
                     /gene="ytpR"
                     /locus_tag="AC0DU4_001679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtpR family tRNA-binding protein"
                     /protein_id="HIN4237606.1"
                     /translation="MIFTYNKEHVGDVLMVIVKNSGDAKLNVERKGKVARVFLKENGE
                     TVAWNIFEVSSLFEIAERGQVFLSDEQVARLNQELQAEGFTEEIVNDKEPKFVVGEIV
                     EMVAHPDSDHLNICQVAVASDKIVQIVAGAPNARVGLKTIVALPGAMMPKGNFIFPGE
                     LRGEKSFGMMCSPRELHLPNAPQKRGVLELSEDQVVGTPFDPAKHWTA"
     gene            complement(4130..4447)
                     /locus_tag="AC0DU4_001680"
     CDS             complement(4130..4447)
                     /locus_tag="AC0DU4_001680"
                     /EC_number="1.8.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin family protein"
                     /protein_id="HIN4237607.1"
                     /translation="MIQPASLEELASLVEKAGKKVFLFVADWCGDCRYIYPALPEIEE
                     TNPEFTFIRMDRDQYMDLAKLWDVYGIPSLVVLEKDKEIGRFVNRDRKSKEQINDFLA
                     GLK"
     gene            complement(4444..4743)
                     /locus_tag="AC0DU4_001681"
     CDS             complement(4444..4743)
                     /locus_tag="AC0DU4_001681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4651 domain-containing protein"
                     /protein_id="HIN4237608.1"
                     /translation="MNGMKAKKMWMAGLALLGIGSLALATKKVADDRKLMKTQEELTE
                     IVRDHFSDMGEIATLYVQVYESSLESLLGGVIFEDGRHYTFVYENEDLVYEEEVL"
     gene            complement(4941..5021)
                     /locus_tag="AC0DU4_001682"
     CDS             complement(4941..5021)
                     /locus_tag="AC0DU4_001682"
                     /inference="COORDINATES: protein motif:HMM:NF039231.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237609.1"
                     /translation="MASSGKMLRNTYTPDGYYVGNLGAWQ"
     gene            complement(5028..5219)
                     /locus_tag="AC0DU4_001683"
     CDS             complement(5028..5219)
                     /locus_tag="AC0DU4_001683"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-binding protein"
                     /protein_id="HIN4237610.1"
                     /translation="MSYSVDDVVSNAFKKRMILDSFFAFNCSGTMKVSTWVYDKGEWY
                     YVSSSGAMIANDWVKDNGK"
     gene            complement(5380..6054)
                     /locus_tag="AC0DU4_001684"
     CDS             complement(5380..6054)
                     /locus_tag="AC0DU4_001684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LiaF transmembrane domain-containing protein"
                     /protein_id="HIN4237611.1"
                     /translation="MKKKAFGIVLLVLAAWILLQGNFGIPSLDGKIWPLLGIVFFAYK
                     SIESILRRHLTSAVFTGLLAIIIANYAYDLLPVTNHSLIWASILVVLGVGYLTHSSKF
                     WNEKKWWYNGKKTVVTDKEVAFGSGTFYKQDQDLVDDQVEVAFGDAKIYYDNAEMLGD
                     FATLNIEVAFGNATVYVPQHWRVDLKVETSFGAAKADAPVAPTSKTLIIRGDVAFGKL
                     EIVYVK"
     gene            complement(6060..6506)
                     /locus_tag="AC0DU4_001685"
     CDS             complement(6060..6506)
                     /locus_tag="AC0DU4_001685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="HIN4237612.1"
                     /translation="MKLRIEIDGNLEETEIVIKTPTLTDEIADLQRLLQESKAPRLTF
                     YKGTGEYYLDLSEILFFETEGSKIYAHNQKEAYEVRLKLYELESILPRYFNRVSKSTI
                     ANIRQIYSVDKSFSGTGTISFYQTHKEVHVSRHYQSLLKENLRNMR"
     gene            complement(6620..7123)
                     /locus_tag="AC0DU4_001686"
     CDS             complement(6620..7123)
                     /locus_tag="AC0DU4_001686"
                     /EC_number="2.7.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HIN4237613.1"
                     /translation="MKNYQEWYRNISSRLTSRPILLFLLRSFNRLMTVAMPLVYLILL
                     VTTYLQLGLGQQVGVYVFIPATGFVILSLLRKKINAPRPYEEWDIKPLLDRDSPGQSM
                     PSRHVFSATIISMTCLHASLTVGFILLVLSALLGLVRVLGGVHYPKDVVVGYICGLAW
                     GVLFFLF"
     gene            complement(7120..7482)
                     /locus_tag="AC0DU4_001687"
     CDS             complement(7120..7482)
                     /locus_tag="AC0DU4_001687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2200 domain-containing protein"
                     /protein_id="HIN4237614.1"
                     /translation="MSQKLYNMKFAAVYLALIAKVERKGGEAESVHQVTSWLTGYEVS
                     DVLACLDRDVTYGDFFRQAPYYVPERIAITGKICGVRIEEIDDPLMQEIRRLDKLVDW
                     LAKGKTSQQVLEKYEKHK"
     gene            complement(7608..8579)
                     /locus_tag="AC0DU4_001688"
     CDS             complement(7608..8579)
                     /locus_tag="AC0DU4_001688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000506433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="HIN4237615.1"
                     /translation="MDFLLMGALFIVLPRTMVSAKRINQVLDLHSSIQNPAQVQLTDE
                     NFKGQVEFKDVTFRYAANSEAVIEHVSFKAETGQTVAFIGSIGSGKSTLVNLIPRFYD
                     VSAGEILVDGVNVQDYDFSATAHAGQRVAIVGPTGAGKTTIVNLLMKFYEIDKGSIRI
                     DGVDTKAMTRSEVHDAFSMVLQDTWLFEGTIRDNLIYNQIGISDERMMEASKAVGIHH
                     FIMTLPDGYDTILDDTVTLSVGQKQLLTIARALLKDAPLLILDEATSSVDTRTEELIQ
                     KAMDRLMEGRTSFVIAHRLSTIRNADLILVMKDGNIIEQGNYEELMV"
     gene            complement(8586..9407)
                     /locus_tag="AC0DU4_001689"
                     /pseudo
     CDS             complement(8586..9407)
                     /locus_tag="AC0DU4_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000601671.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
     gene            complement(9424..9895)
                     /locus_tag="AC0DU4_001690"
                     /pseudo
     CDS             complement(9424..9895)
                     /locus_tag="AC0DU4_001690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360543.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
     gene            complement(10019..>10165)
                     /locus_tag="AC0DU4_001691"
     CDS             complement(10019..>10165)
                     /locus_tag="AC0DU4_001691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015604432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HIN4237616.1"
                     /translation="EFQVTELEMIPQSEVELSGEDLETFEKLYSVLEDDEDVQKIYTN
                     VDGF"
BASE COUNT         2944 a         2398 c         1882 g         2941 t
ORIGIN      
        1 tttttataag ttgttttcta tagaaagctt acatcatccc gcccatcatg cttggatcca
       61 ttgctggagc tggggctact ggttctggtt tattggctac gactgcttct gttgtcaaaa
      121 tcaagctggc tacagatgct gcattttgta gggctgaacg actcacttta actggatcaa
      181 tgataccttg atcaatcatg ttaacccact cgccagttgc tgcgttgaat cctataccaa
      241 gctcagcatt tttcaaacga tcgataacga tagatccttc aaatcctgca ttgtgagcaa
      301 tttgacgaac aggttcttcc aaagcacgga gaacaatatt acgtcctgtt gcttcatctc
      361 ctgtcaattc caaggtagca acagctggaa tcacattggc aagagctgtt ccaccacctg
      421 caacaatacc ttcttcaaca gctgcacgag tagcgttgag ggcatcttca atgcggagtt
      481 tcatttcttt caactcagtt tcagttgcgg ctccgacctt aataaccgct acaccacctg
      541 acaatttggc caagcgttct tgcaattttt cacggtcaaa ttcagaagtt gtagtttcga
      601 tttgagactt gataaccgca acacggtgag aaatcgcttc aggatttcct gcaccttcta
      661 caataaccgt gctatctttg tccacggtca ctctcgctgc ttgaccaaga gcttcaattg
      721 tcgcatcttt caactcaaga ccaaggtctt ctgtgataac tgttccgcct gttaagatgg
      781 cgatatcttc aagcatagct ttgcgacggt caccaaaacc aggtgccttg actgctacta
      841 cgttgaaggt tccacgaatc ttgttcaaaa caagagttgg aagagcctcg ccatccacat
      901 catccgcaat aatcaagagt ggacgattgc tttggagaat gctttccaaa agtggcaaga
      961 tttcttggat attggaaatt ttcttgtctg taatcaaaat gtacggattt tcaaggtcag
     1021 ccaccatttt ttcgctatct gtcaccatgt actgtgaaag gtaaccacgg tcaaactgca
     1081 ttccttctac gacttcaagc tctgtttcca taccacgtga ctcttcgatg gtgatgacac
     1141 cgtctttgcc aactttttcc attgcttcag agatgtactc accaactttt tcagaacgag
     1201 aagatacggc tgcaacttga gcgatagctt ctttattggc aacagggatg gcgttgtttt
     1261 tcaaagcttc aactgctgcg gcaactgctg tttcaatccc acgacgaata ccgattggat
     1321 ttgcacctgc tgtgacgttt ttgattcctt cacggacgat agcttgggtc aagactgttg
     1381 cagtcgtagt tccgtcacct gcgatatcat tggttttaga agctacttct gatactaact
     1441 tagcacccat attttcaaaa tggtcttcca attcgatttc tttggcaatg gtcacaccgt
     1501 cattggtaat caagggtgaa ccgaatgact tttcaagaac gacattgcga ccttttggtc
     1561 ccaaggttac tttaacagtg tctgcaagga tatcgacacc acgaaccatg gctgaacggg
     1621 catctgatga aaatttaatt tcttttgaca tacttacttt ctccttctat tcctcaatga
     1681 ttgccaagat gttagcttcg cctacgatga tgtacttttc atcgccatct ttgacatcaa
     1741 gacctgcgtg ggcttcaact aagacacgat ctccagtttt aacacttgga gcaaccaagt
     1801 caccgttcaa ggtacgaaca ccttgtccag tagccacaac ttgagctgtt ttggtttttt
     1861 cttgggctga gcctgcaagg acaaagcccc caacggtttg ttctttttct tctattttta
     1921 agaccacacg gtcccctaat ggtttcaaca tctgatttcc tccataatga gatagatatt
     1981 attagcactc tttgaacttg agtgctaatt cataattcta ttgtatcact tggtcagaaa
     2041 tagtcaagaa aaaagtctga ctttctcaag ataaaaagcc tgagaccaac tcagactttt
     2101 taatgtttat actcaatgaa aatcaaagag caaactagga agctagccgc aggctgctca
     2161 aagcattgct ttgatgttgt ggataaagct aacgtggttt gaagagattt tcgaagagta
     2221 ttaaaatggc aattcttcct cttccaagac caaatctgcc aaatcttggc ctgcattatt
     2281 ttcacgcatg gcacgttgag cacgactttc taagagttgg aatcctgtca caaggacttc
     2341 ggttacatag ttcatctgac catttttctc aaagcgacgg gtacgcaatt ctccatcaac
     2401 ggaaatgaga ctacctttgg ttgcgtagct tgccaaagtt tctgctagcc tgccccatag
     2461 gaccatattg acaaaatcag cttcacgttc accgttttgg tctttgtaac gacggttgac
     2521 agcgatagtt gctcgcgcta ccgacttgtc attgttggtt ttgtgcaatt ctggtgtaga
     2581 cgttaaacgc ccaatcaaga taactttatt atacatattt tcttcctcct acttatctat
     2641 tcgtaggaaa tcaaaaaaag ttacagaaat ttgtaacttt tcgaggaaat ttcttatttt
     2701 ttatgaatca tgaaacctgt cgcctgttga ttggccataa tggtcatatc tgtaatctga
     2761 acacggcgag gctgactggt cacatagact actgtgtctg caatatcctg agcttgcaag
     2821 gcttctattc cttggtaaac ggacgcagcc cgctctttat caccatgaaa acgaacagtt
     2881 gagaaatctg tttcgacaat cccaggctga atggttgtca ccttgatatc cgttgcgatg
     2941 gtatcaattc gcagtccatc cgaaaaggtc ttaaccgcag ccttggtagc tgagtaaaca
     3001 gcggcaccag cataggcgta gattcctgcg gttgacccca tattgataat atgaccttga
     3061 ttgactttta tcattgctgg caagaaacag cgagtaaccg ccatcagacc tttaacattg
     3121 gtatccaaca tggtcaacat atccaactcc tcatagtctt gatagggagc caagtcaaga
     3181 gccagtccgg cgttgttgac caagatatca atcctcccta tcgtttctag aatatcagag
     3241 caaacagtct tcaccatgac catatccgtc acatctagtg gaaaagtcca gacggtttga
     3301 tttggaaagc ttactgcaaa ctccgacttg aggatttcta atctgtctat ccgtcgtcct
     3361 gttagaacga catcctcacc ctgctccaga taagcacgcg caatcgcttc accgattcct
     3421 gaggttgctc ccgtaatcac tacatttttt gccatcttat ttccttctat cagatgctga
     3481 caagttccta ggcagtccag tgtttcgctg ggtcgaacgg tgttccgaca acttggtctt
     3541 ctgataattc aagcacccca cgtttttgcg gagcatttgg caaatgcaat tcacgaggac
     3601 tacacatcat cccaaaactc ttttcaccac gaagttcgcc tgggaaaatg aaattccctt
     3661 ttggcatcat ggcaccagga agagccacaa tggttttcaa cccaacacgc gcattaggtg
     3721 ctcctgcaac gatttgcact atcttgtcac ttgcgactgc aacttggcag atgttgaggt
     3781 ggtcactgtc tggatgagct accatctcga caatttcacc aacaacaaac ttaggttcct
     3841 tatcattaac aatttcttct gtaaaacctt ccgcctgtaa ttcttggttc aaacgagcga
     3901 cttgctcatc tgataaaaag acttgaccgc gctctgcaat ttcaaacaag ctcgaaacct
     3961 caaaaatgtt ccaagctact gtttccccat tttctttgag gaaaacacgg gctaccttgc
     4021 ctttgcgttc cacattcagt ttggcatctc cgctattttt cacgatgacc ataaggacat
     4081 caccgacatg ttctttgtta tacgtaaaaa tcattgtttc ctttttctcc tatttcaatc
     4141 ctgctaaaaa atcgttaatt tgctccttac ttttacggtc gcgattgaca aaacgaccga
     4201 tttccttgtc cttttctaga acaacaaggc taggaattcc gtaaacatcc cagagtttgg
     4261 ccaaatccat atactgatct cggtccattc gaataaaggt gaactctgga ttggtctctt
     4321 caatctctgg taaggcagga taaatataac gacaatcgcc acaccagtct gccacaaaaa
     4381 ggaagacctt cttgcccgct ttttccacta aagatgctaa ttcttctaaa cttgctggct
     4441 gtatcataag acttcctcct catagactag gtcttcattt tcatagacaa aggtataatg
     4501 acggccatcc tcaaaaatga cgccaccaag caagctctct agactgcttt catagacttg
     4561 aacatagagg gtcgcaattt cccccatgtc tgaaaaatgg tctcgcacaa tctctgtcaa
     4621 ctcttcctga gtcttcatga gcttacggtc atctgcaact tttttcgtag caagagcaag
     4681 gcttccgata cctagcagag ccaagcctgc catccacatt tttttagctt tcataccatt
     4741 cattttaaca caaaaaaggc ttcaggacaa atgaggaagc agcagaaaag caagtaaaaa
     4801 gcctcttcct ttaaggaaaa ggacttctta tactaagagc aaactagaaa gctagccgca
     4861 ggctgctcaa aacacggttt tgaggttgta gataaggcga cgttgacgtg gtttgaagag
     4921 attttcaaag agtattattc ttattgccag gcacctaagt tgccaacgta gtaaccatca
     4981 ggtgtgtagg tattgcgaag catcttacct gatgaagcca gataatacta cttgccattg
     5041 tctttgaccc aatcattcgc aatcatggca ccagaagaac ttacataata ccattctccc
     5101 ttgtcataaa cccaagtact gactttcatg gttcctgagc aattaaaggc aaaaaaactg
     5161 tccaatatca ttcgtttttt aaaagcattt gacactacat catctacgct gtaggacata
     5221 gatgcatcaa acgtaaaagc caaaatatcg aaaaatatac aacttttaaa ggcagcattt
     5281 cattttttaa agtctaacaa ccatagaact gaaatcagag caaggcatca atttcctact
     5341 cttagtacgt ctattttgat ggttgaagtg aagatttttt tatttaacgt agacaatttc
     5401 caacttccca aaagccacat ctccacggat aatcaaggtt ttgctggttg gggctacagg
     5461 agcgtcagcc ttagctgcac caaaggaggt ttctactttc aaatctacac gccagtgttg
     5521 tggaacatag acggttgcat ttccgaaggc cacttcaata tttaaagttg caaaatcacc
     5581 tagcatctct gcattatcat agtagatttt agcatcccca aaagcgactt ccacttggtc
     5641 atctacgaga tcttgatctt gcttatagaa ggtcccgcta ccaaaagcga cttccttatc
     5701 cgtgacgact gtttttttcc cattgtacca ccattttttt tcattccaga acttacttga
     5761 atgcgtcaga taaccaacac caagtaccac caagatgcta gcccaaataa gagaatgatt
     5821 ggtaactggt aacaagtcat aagcgtaatt tgcaatgatg atcgccagta aacctgtaaa
     5881 aactgccgaa gtgagatgac gtctaaggat ggactcaatg gacttataag caaaaaaaac
     5941 aatacctagt aaaggccata ttttaccatc caaagaagga attccaaaat tcccttgcag
     6001 caagatccaa gctgctaaaa ccaataaaac aataccaaat gctttctttt tcatgttttt
     6061 tacctcatgt ttcttagatt ttcttttagg agggattggt aatgccgtga gacatgaacc
     6121 tccttgtgcg tctgataaaa ggaaatggtg cccgttcctg aaaaggactt gtccactgag
     6181 taaatctgac ggatgtttgc gatcgttgac ttggaaactc gattaaaata gcgaggcaag
     6241 atagactcca actcatagag cttgaggcga acctcataag cttccttctg gttatgagcg
     6301 tagatcttgc tcccttctgt ttcaaagaag agaatttctg acaggtctag ataatattca
     6361 cctgtcccct tgtaaaaagt caacctcgga gcctttgact cttgcaagag ccgttgcaag
     6421 tctgcaattt catctgtcaa agtgggggtc ttgatgacaa tttcagtctc ctctaaattg
     6481 ccgtcaatct caattcgtaa cttcatcaca tctcctttct gactctacta tatcaaagct
     6541 aagttaggaa tacaagggca aaaaagcaag tggtcaattt gaagcagtaa gtggttgcaa
     6601 gaccaactta acttacaggt caaaatagaa agaaaagcac accccacgca agaccacaaa
     6661 tataaccaac tactacatcc ttgggataat gtacaccacc taagactctc acgagaccga
     6721 ggagggctga caagaccaac aagataaagc ccacagttag actagcatgt aagcaagtca
     6781 tggagataat ggttgctgaa aagacatgac gactgggcat agactgacca ggactatctc
     6841 tgtcaagcaa gggtttaata tcccattcct cataaggcct aggggcattg attttcttac
     6901 gaagaaggga taaaatcaca aaacctgtag cagggataaa cacataaacc ccaacttgct
     6961 gaccaagtcc tagttgcagg taagtggtga ctagcaagat cagatagacc aggggcatgg
     7021 cgactgtcat caaacgattg aaactgcgta ataggaataa aagaattgga cgactagtta
     7081 gtctggagct gatatttcga taccattctt gataattttt catttatgct tctcatactt
     7141 ttctagaact tgttgagatg ttttcccctt ggcaagccaa tccactagct tgtccaagcg
     7201 acgtatttcc tgcatcagag gatcatcaat ttcctcaata cggacaccgc aaatcttccc
     7261 tgtaattgca attcgttcag ggacataata tggtgcttgt cgaaaaaaat ctccgtaagt
     7321 aacatcccta tccagacaag caagaacgtc actcacttca taccctgtca accaactggt
     7381 cacttggtga actgactctg cctctccacc ctttcgctca acttttgcaa tcaaggctaa
     7441 atagacagca gcaaatttca tattgtataa tttctgactc atacttctct ctttctatgt
     7501 gtactagtat aaataagaaa aagaaggccg tcaagccttc ttttgattta ttcttctgct
     7561 tcatcttctg taaattgact attgtacaag tcagcgtaga agccacctta caccatcagt
     7621 tcctcatagt tgccttgctc gatgatattt ccatctttca tgaccaagat caagtctgca
     7681 tttcggatgg ttgacaagcg gtgggcaatg acaaaggatg tgcgtccttc catcaaacgg
     7741 tccatggctt tttggatcaa ttcctctgtc cgtgtgtcaa cagaagaagt cgcctcatcc
     7801 aaaatcaaaa gcggtgcatc cttaagaagg gcacgagcaa tagtcaatag ttgtttttgt
     7861 cctacagaca aggtcacggt gtcatccaag atggtatcat agccatctgg caaggtcata
     7921 ataaagtggt gaattcccac agccttacta gcttccatca ttcgttcatc actaatccct
     7981 atttgattat agatgagatt gtctcgaata gttccttcaa agagccaggt atcctgcaag
     8041 accattgaaa aggcatcatg cacttctgaa cgcgtcatag ccttggtatc cacaccatca
     8101 atgcgaatac ttcccttatc aatctcatag aatttcatca aaagattgac aatggttgtc
     8161 ttaccagccc cagtcggccc aacaatggca accctttgac cagcatgagc tgtcgcagag
     8221 aagtcatagt cttgaacatt gacaccgtcc accagaattt ctcctgctga cacgtcgtag
     8281 aaacgtggaa tcagattgac cagagttgat ttaccagaac ctattgaccc aataaaggcc
     8341 actgtttgac cagtttctgc tttaaagcta acatgttcaa taactgcctc cgaatttgcc
     8401 gcatagcgga aggtcacatc cttaaactcg acctgacctt tgaagttttc atcagtcagc
     8461 tgcacttgag cagggttttg gatagaagaa tgcaaatcta aaacttgatt aatccgctta
     8521 gcagagacca tagttcgggg aagaacgatg aagagtgctc ccatgagaag gaagtccatg
     8581 acaacctaca tggcataaga catgaaaaca atcatgtcac taaagagagg cagacgcgct
     8641 atcggagcag cgtcgttaat cacataggcc ccaatccagt aaatcgccac actcaaacca
     8701 cttgaaatcc ccatcatgat aggattcaaa atagccataa gacggttgac aaacaaattt
     8761 taacgggtca attcatcatt tactgctgca aatttttcat tttgataatc ctctgcattg
     8821 taggcacgaa cgacacgaat acctgttaaa ctctcacgag tgatactgtt cagtttatct
     8881 gtcagcccct gaatcaagga ctgttttgga aaggctagcg tcatcaaaac ggtcgtcatc
     8941 aggacgttga caatcactgc cacaagtacg gcccagagcc agtattctga atgacctaaa
     9001 atcttcccaa tagcccagat agccataatt ggaccacacg ttaccacttg caagtccata
     9061 gtaatcaaca tttgaacttg agtaatgtca ttggtagtac gcatcaagag gctaggaatt
     9121 gaaaatttct taatctctgt ctgcgagtaa tccaaaactc ggttaaaaat atcacttctc
     9181 agcctactag tataagaagc cgccactcgg gatgcaaaaa atccaactgc aactacggac
     9241 aagaaggcaa gaaagggcat tcccatcatc atgcttgccg gctgccacaa ctcatctaaa
     9301 ttagtttctt gactacctag caaatccgta attttcgaga tataggtcgg cacttccaac
     9361 tctagataga ccgaaaagca agtaaagaga atggctagta aaatcatccc ccattctttt
     9421 ctactaattc ttttggttaa tttctttatt ctctcctcct attcccttga tattttgcct
     9481 gtagttgacc gagaactttc tcaaaaatca gtaattcatc ttcatcaatg tcttccatca
     9541 actgcttgtc tatgcgttca aaaaaagcct taacctgttg catctgagaa cgtgctttgt
     9601 ccgtcagacg aacaaactta gcccgcttat caacaggact cgcctccaat tccaccaaac
     9661 cattttgcac tatacgctta accagattac tagcaacaga cttggtaata ttgagttcct
     9721 gctcgatatc tttaatcaag accaagtctt gatttttcta gcgattatcc aaaaaacgca
     9781 caacctgacc ttgcggccca cccataaatt caatgccgca acgtttggct tccttttgca
     9841 ccatcaggta aatttgatga ccaaaacgct taaagactaa catcggttta tccataatct
     9901 cccccttcta aataaaaata gttctctgga gaataattaa atttctatga gaactatttt
     9961 cttgattaaa aaaatcccaa gtgattttct cacttaggat catgttctat aggttaaatt
    10021 aaaacccatc tacgttcgta taaatctttt ggacgtcttc gtcgtcttca agaacgctgt
    10081 aaagtttttc aaaggtttca aggtcttcgc ctgacaattc cacttctgac tgaggaatca
    10141 tttccaattc agtcacttgg aattc
//
LOCUS       DBMVGT010000062        10121 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.062, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000062 DBMVGT010000000
VERSION     DBMVGT010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10121)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10121)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10121
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.062"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            168..854
                     /locus_tag="AC0DU4_001692"
     CDS             168..854
                     /locus_tag="AC0DU4_001692"
                     /EC_number="5.1.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000448315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047465 - N-acylglucosamine-6-phosphate
                     2-epimerase activity [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006051 - N-acetylmannosamine metabolic
                     process [Evidence IEA];
                     GO_process: GO:0019262 - N-acetylneuraminate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HIN4237617.1"
                     /translation="METKKIKNLKGQIIVSCQALEGEPLYTPNGGVMPLLAKAAFQAG
                     AKGIRANSVRDISEIKEEVDLPIIGIIKRDYDGFEPFISATMKEIDELVSEGVDILAL
                     DCTNRSRPGYDNITDFIHDIKVKYPNQLLMADISTFEEGKVAAESGVDFVGTTLSGYT
                     PYSPKKDNPDFELVERLVKELDVPVIAEGRISTPEQARKMLDLGAYAVVVGGAITRPL
                     EIAKKFIEVV"
     gene            855..1787
                     /locus_tag="AC0DU4_001693"
     CDS             855..1787
                     /locus_tag="AC0DU4_001693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001071049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237618.1"
                     /translation="MNQEILKKSKIQLTVEHIQKYWILYLMMIPATVLLILFTYGPMY
                     GIIMAFQDFTVFKGYTGSPFVGLKHFQRLFSDPLFYRLFKNTFMVGVLDFLFSFPAPL
                     IFALILNEVRKVRFKSVVQSISYLPHFIPLVVMVGIIFELFGSYGIINSLLSSLGMEP
                     ISFFTKSEWFLPLYIGSGVWKTIGWGSIIYMGALTNIDSTLYEAADMDGANRWHKMWH
                     VTLPSLRPTVVTLFILNAGGIMQVGFEKVFLMSSPATYEVSDVLSTYVYRQGILNSDF
                     SYSAAVGLFNNIVALLFVLLANKIAKKLGEEGIV"
     gene            1798..2727
                     /locus_tag="AC0DU4_001694"
     CDS             1798..2727
                     /locus_tag="AC0DU4_001694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000577774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HIN4237619.1"
                     /translation="MIFSKNTKKSNRDKETFVDYLFIFILIIITLLMLYPLWWVVMTS
                     LSEPVWLSKNVVKLFPLKIDITAYKFIFGDSKLWQAYGNSVLYAALSTIVSVAVCSMY
                     AYPLTIPEIRGKKFWNTLILIPMFFSGGMIPLYIQVANLGLLNTAWALVLPGAVSTYY
                     IILFRTQFKSIPMELRESARIDGASEFRIFWNLVLPLSKVIFMIIALYCIVGSWNSFT
                     PPLLYLNDDTKMPLSIYLRNLVVTNTTDTAELSLSAGNTYYQQIAAQGGGIGMRIAIK
                     MGTIVVSVIPIMMIYPFIQKHFVKGILLGSVKG"
     gene            2741..4180
                     /locus_tag="AC0DU4_001695"
     CDS             2741..4180
                     /locus_tag="AC0DU4_001695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001178946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237620.1"
                     /translation="MQNLKKYLLLDSGLVVGYTLENAQLKLNKLKKDTENNPLFGEEY
                     FAENPKLWEVRFDNSYPNVIYDKELKLYRCWYQTFVSDEASEETPLAERGEKEYIVKS
                     SRMTALCYAESKDGVKWEKPNLNLVKFKGSKDNNIVLMHAHGAGIMLDEQELDPKKRY
                     KLVSKLEFSPNLHYMVVVFSEDGIHFDEPIPWKKWNPAADSHNFPFRDPKTGKYAVIT
                     RTWANNVRLSAITFSDDFINWSEPKEILRGDGFEDQIYSMPVISYADIYLGFASMYHE
                     GDTLNENYDKVDLELKFSANLEQWDSVCKGDYLIERGGGVYPQNADFDASCIFTAAPI
                     IEDDKIWFYYMGGNGNHTGFRESSLARGYIKKDQFAYYTNKREGIPAKISTVSFQTYD
                     DEIYILADIPENGYIKVAVGTKYGNAYSDFGQEDISLVQVSDGKYKLEFNKKSILDLG
                     NSPVAFKFEIENAKLYGIEGSIQQHYLKY"
     gene            4249..5826
                     /locus_tag="AC0DU4_001696"
     CDS             4249..5826
                     /locus_tag="AC0DU4_001696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HIN4237621.1"
                     /translation="MVKLNKVLKGSVAFLSASLLLAACGNNANSKPAEKTADGKTKIS
                     FLSTWQINDVRPPKDETLVGQWLEEQLGIDIDLVTIPGEGVSSKVNSLITSNQLPTVL
                     LTTGDKSDIAGINKLGKQGAFLDLSQHMDKLPNYKKYLEKNNALAQIEDDEKHIYAFT
                     KFFTDENIMYTTPILRKDLLVGSEFEDLSKIKTVDDYTKVLKYLTEKQGSPAFIQRNG
                     YEGFMKRVTPLWNLSHRTYYDYESDSYKHPVEQPQLKQFVEWLKELRKDNVLHPDWAV
                     MKDETWEGLLASNKGSFTVDRMNIIGDNNFDKSFDWQPLVYPKINGKRYLQPKTPYIS
                     DSGWVINANAPKEEIDKALEFFNFLYADENQEKLAIGFEGKTFTRENPNTQAGIKWLI
                     QIYGENAGNDKAELLFKHGNQAFTRVQTKLDIEAQPGTFPKVMYDQVDKIKKDLGGFR
                     PDTPVLSFTTEELDVLTKSEAGLNTFFDENIIKFIEGQRDMSEWDSFINEAKSKDLDK
                     VTKVYNDAYKRVKDRMK"
     gene            5886..7346
                     /locus_tag="AC0DU4_001697"
     CDS             5886..7346
                     /locus_tag="AC0DU4_001697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000272432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HIN4237622.1"
                     /translation="MYDVVIIGAGSSGALAAIASGRLGLKTCLIEKGSRIGGVPINTL
                     MGSFANLYFDDSGRVNASKIVGELIERIIKKGGTVFNSMEELMNVNDFYQITIPYQPE
                     VYESVLTDMLIESKVDILLNIEVNNIIYDSKNIKSLEILSNQEVKLIDSKVFIDATGN
                     ATIASASGADVYEKNSSYGCLMRVGGVDISKTIEHIEKTKQWNYIEGYNQWLEEVLAN
                     RKYRATGAVLKDPVSYDHAPMLSKDDHFMNDEKWNYIKERWEKFRFIYTLEVSLFRNE
                     LKKAVESGDFNFEIYHDDKSGVTMNGDGISYGSWGQNVALINVAKAFGFNPKYMEDES
                     HANILSRKYNLTFLSFLKKYVPGFENSFILDQGTRATNRSCRHIDNSSMMDEILDFPM
                     YTFKTMYSYQTPKEITYKSIVGGKLNNLFVIGKGAYQSESFRSQISCMLMGISSAAAA
                     KTIIEDKSNTLNINRDLFKSNLDILFTWEFSNWITD"
     gene            7368..7823
                     /locus_tag="AC0DU4_001698"
     CDS             7368..7823
                     /locus_tag="AC0DU4_001698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001000318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HIN4237623.1"
                     /translation="MNDTNKNQYFVYEFDTSFVEMSYSQFFEGYCILFSKEPYPSLSD
                     MPMEFRKEFLMEMSILGDAMLEVLNAYRINYDILGNSTPVLHAHLFPRYMWEEEERRK
                     TVVHRYDSSVFSNPEFEFTIEKHGPIIKKLRSAIDRHYREYQQLLDDSN"
     gene            8035..8316
                     /locus_tag="AC0DU4_001699"
     CDS             8035..8316
                     /locus_tag="AC0DU4_001699"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: protein motif:HMM:NF004064.0"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004126 - cytidine deaminase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0009972 - cytidine deamination [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase family protein"
                     /protein_id="HIN4237624.1"
                     /translation="MENAAFSPTCCAERVSFYKAVFKGERSFSRICIVGGKNGILSSF
                     IAPCGVCRQVMIEFCNSDSFEVILASDVDTYKVYKLKELLPVSFNQENL"
     gene            8329..8778
                     /locus_tag="AC0DU4_001700"
     CDS             8329..8778
                     /locus_tag="AC0DU4_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HIN4237625.1"
                     /translation="MELVEFKNGHVNTVHEHIAITKVKEFLNNHDIPKDKGGIHKIST
                     DFFYNIIDMETTTEENRPWESHKEYYDVHYLLNGEEIILYNFLSQMELSEYKVDDDWQ
                     QMNGTALFSIKLKKDMLLLLEPNDAHKTGLLVEEPLNIKKVVFKVKI"
     gene            complement(8890..9937)
                     /locus_tag="AC0DU4_001701"
     CDS             complement(join(8890..9501,9503..9937))
                     /locus_tag="AC0DU4_001701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612110.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HIN4237626.1"
                     /translation="MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVLFRLMGKSYKEIIE
                     LLDCNQTTIWRNVKKYEEFGLDSLLQETRGGRNHAYMTVEEEKAFLARHLKATEAGEF
                     VTIDALFQAYKKELGRSYTRDAFYQLLKRHGWRNITPRPEHPKKQTLKPLSRLKIKSQ
                     FKKTRKRFKTSRPFHKVRLMYQDEAGFGRISKLGSCWSPIGVGPHVHSHYIREFRYCY
                     GAVDAYTGESFFLRAGGCNTEWMNVFLEELSQAYPDDYFLLVMDNAIWHKSSILKIPT
                     NIGFAFIPPYTPEMNPIEQVWKEIRKRGFKNKAFRILEDVMNQLQDVIQGLEKEVIKS
                     IVNRRWTRMLFESR"
BASE COUNT         3460 a         1399 c         1884 g         3378 t
ORIGIN      
        1 gtgtattgaa tctataacag tacgccttaa atgctaaaat atttctataa attaatttaa
       61 ctttcctgat agggctgttc atatcttatt tcaattcact atataaataa aattgtagta
      121 gatgttattg aattagtaaa aaaaataaaa aaacggaggt tttctgaatg gaaactaaaa
      181 aaattaaaaa tttaaaaggt caaataattg tttcctgcca agcgttagaa ggagagccac
      241 tttatactcc aaatggagga gtgatgccgt tattagcaaa agccgccttt caagcaggcg
      301 ctaaaggtat tcgtgctaat tctgtccgcg atatttcaga aataaaagaa gaagttgact
      361 taccaattat aggtatcata aaaagagatt acgatggctt tgaacctttt atttcagcaa
      421 ctatgaaaga gattgatgaa ttagttagtg aaggagtaga cattttagct ttggattgta
      481 ctaatcgttc aagaccaggt tatgataata ttactgactt tattcatgat attaaagtca
      541 agtatccaaa ccaattatta atggctgata tttctacttt tgaagaaggg aaagtagctg
      601 ctgaatcggg agtagatttt gtgggtacga cattatctgg ttatacacca tatagcccta
      661 aaaaagataa tcctgatttt gagttagttg aaagattggt aaaagagctt gacgtaccag
      721 ttattgctga aggaagaata agtactccgg aacaagctag aaaaatgtta gatttaggtg
      781 cttacgcagt ggttgttgga ggagctatca ctcgtccttt ggaaatagcg aagaagttta
      841 ttgaggtagt ttagatgaat caagaaatat taaaaaagag taagattcaa ttgacagttg
      901 aacatattca aaaatattgg attttatatt taatgatgat tccagcaact gttctactaa
      961 ttttatttac gtatggacca atgtacggca ttattatggc ctttcaagac tttactgtct
     1021 tcaagggata tactggaagt ccatttgtcg gtttaaaaca ttttcaaaga ttgttctcag
     1081 atcctttgtt ttatagattg ttcaagaata cgttcatggt aggggtttta gactttttat
     1141 tctctttccc agctccgctt atttttgcac tcatattaaa cgaagtcaga aaagtaagat
     1201 ttaagagtgt agttcaatct attagttatc ttcctcattt tattccccta gtggttatgg
     1261 ttggtattat ttttgaacta tttggttcat atggtattat taacagttta ctttcatcac
     1321 ttggaatgga gccaataagt ttctttacaa aatctgaatg gttcttgcct ctctacattg
     1381 gttcaggagt atggaaaaca ataggttggg gttctatcat ttatatggga gcattaacca
     1441 atatagattc aactttatat gaagcagcag atatggacgg ggctaataga tggcacaaaa
     1501 tgtggcatgt aactctacca agtttaagac ctacagtagt tactttgttt atactaaatg
     1561 ctggtggtat catgcaagta ggatttgaaa aggtattctt gatgtctagt cctgcaacat
     1621 atgaagtatc tgatgtatta tctacttatg tttatagaca aggtatttta aattctgatt
     1681 tcagttactc agctgcagta ggattattta ataacatagt agctttgtta tttgttttat
     1741 tagctaataa gattgctaaa aaacttggcg aagaaggaat tgtataaggg gggtaaaatg
     1801 attttttcaa aaaatacaaa aaagagtaat agagacaaag aaaccttcgt tgattatctc
     1861 tttatattca ttttaataat aataacctta cttatgttgt atccattatg gtgggtagtg
     1921 atgacgtcac tttcagaacc agtttggcta tctaaaaacg ttgttaaatt atttccctta
     1981 aaaatagata ttactgcata taagtttatt tttggggatt ctaaactatg gcaagcatat
     2041 ggtaatagtg tattgtatgc tgcactatct acaattgtta gtgttgcggt atgtagtatg
     2101 tatgcctatc cacttacaat tcctgaaatt aggggtaaaa aattctggaa tactcttatt
     2161 ttgattccaa tgttctttag tggaggaatg atcccgcttt atatacaagt tgcaaacctc
     2221 ggtttattga atactgcttg ggctcttgtt ttacctggtg ctgtttctac atattatata
     2281 attttgttta gaacacagtt taaatcaatc ccaatggagc ttcgtgagtc tgctagaatt
     2341 gatggggcaa gtgaatttag aattttttgg aatttagtat taccattatc aaaagttatt
     2401 ttcatgatta tagcacttta ttgcatagtt ggttcatgga atagttttac tcctccatta
     2461 ctttatttga atgacgacac taagatgcct ttatctattt atttgagaaa tttagttgtt
     2521 acaaatacaa ctgatactgc tgaattatca ctttctgcag gtaatacata ttaccaacaa
     2581 attgctgctc aaggtggagg tattggtatg cgtattgcta ttaagatggg tactattgtt
     2641 gttagtgtta ttccaattat gatgatttat ccatttattc agaaacattt tgttaaggga
     2701 atcctgctag gttctgtgaa aggttaataa ggtaattatt ttgcaaaatt taaaaaaata
     2761 tcttttatta gatagcggtt tagtagttgg gtatacatta gaaaatgctc aattaaaatt
     2821 aaataagcta aaaaaagata ctgaaaacaa tccactattt ggtgaagagt attttgccga
     2881 aaatcctaaa ttatgggaag ttcgttttga taattcatat ccaaacgtta tctatgataa
     2941 agaattgaaa ttatatagat gttggtatca aacatttgtt agtgatgaag caagcgaaga
     3001 gactccttta gcagaacgtg gagagaagga atacattgtc aagtcatcta gaatgacagc
     3061 actttgctat gctgaaagta aagatggagt aaaatgggaa aaaccaaatc tcaatctagt
     3121 aaaatttaaa ggttcaaaag ataataatat tgttctgatg catgcacacg gtgcaggtat
     3181 catgctagat gaacaggagt tggatcctaa gaaacgatat aaattagttt caaaattaga
     3241 attttctccg aatcttcatt acatggttgt tgttttttca gaagacggta ttcattttga
     3301 cgaacctatt ccatggaaaa aatggaatcc tgcagcagat agtcataatt ttccatttag
     3361 agatccaaaa actggtaaat acgctgttat tacaagaacc tgggcaaata acgtacgtct
     3421 aagtgcaatt actttcagtg atgattttat taattggtca gaacctaaag aaatccttag
     3481 gggagatgga tttgaagatc aaatttattc tatgccagta atttcatacg cggatatcta
     3541 tttaggtttt gcttcaatgt accacgaagg cgacacttta aatgaaaact atgataaagt
     3601 agacttagaa ttgaaattct ctgctaattt ggaacaatgg gatagtgtat gtaagggcga
     3661 ctatctcatt gaaaggggag gtggagtata cccgcagaat gctgattttg atgctagttg
     3721 tattttcacg gctgctccaa taattgaaga tgataagatt tggttctact atatgggtgg
     3781 aaatggtaat cacactggct tccgagaaag ttcattagct agaggatata ttaagaaaga
     3841 ccaatttgct tattatacta ataagagaga aggaattcca gctaaaatat ctacagttag
     3901 cttccaaact tacgatgatg aaatttatat cttagctgat attcctgaaa atggttatat
     3961 taaagttgcg gtaggtacta aatacggtaa tgcttattca gattttggtc aggaagatat
     4021 ctctcttgtt caagtttccg atggtaagta taagttggaa tttaataaaa aatctatctt
     4081 agatttaggt aattctccag ttgcgttcaa atttgaaatc gagaatgcaa aattgtatgg
     4141 tattgaaggt agtattcagc aacactatct caaatattaa ccagaataat tcgttaacaa
     4201 ataatctcta tattagtgga gatagatata taaaatggag gtcttattat ggtaaagctt
     4261 aataaggtat taaaagggag tgttgcattc ctgagtgcaa gtttattgct agcagcttgt
     4321 ggcaataacg ctaattcaaa gcccgctgaa aaaacagctg atggtaaaac gaaaatttcg
     4381 tttctatcta catggcaaat taatgatgtt cgtccgccta aagatgaaac acttgttggt
     4441 caatggttag aagaacagct aggtattgat attgatcttg taactattcc tggcgaggga
     4501 gtaagttcta aagtaaattc tcttattact agtaaccagt taccgactgt tttgttgaca
     4561 acaggagata agagtgatat cgctggtatc aacaaacttg gtaaacaggg tgcattctta
     4621 gatttgtcac aacacatgga caaactacca aactataaga agtaccttga aaaaaataat
     4681 gcattagctc aaatagaaga tgatgaaaaa catatttatg ctttcacaaa attctttact
     4741 gatgagaata tcatgtatac tacaccaatt ctgagaaaag acttacttgt tggttcagaa
     4801 tttgaagatc tttcaaaaat taaaactgtt gatgactata caaaagtttt gaaatatttg
     4861 actgaaaaac aaggttctcc agcatttatt caacgtaatg gctatgaagg cttcatgaag
     4921 cgagttacac cattgtggaa tttaagccat cgtacatact atgactatga atcagattca
     4981 tataaacatc cagttgaaca acctcaattg aaacaattcg ttgaatggtt gaaagaatta
     5041 cgtaaagata acgtacttca ccctgactgg gcagttatga aagatgaaac ttgggaaggt
     5101 ctattggctt ctaacaaggg ttcattcact gttgaccgta tgaatatcat tggagataat
     5161 aactttgata aatcatttga ttggcagcca cttgtttatc caaaaattaa tggaaaacgt
     5221 tatttgcaac cgaaaacacc gtacatttct gattcaggtt gggtaatcaa tgccaatgca
     5281 ccaaaagaag aaattgataa agcgttagaa ttctttaatt tcttatacgc tgatgaaaat
     5341 caagaaaaac ttgctattgg atttgaaggt aaaacattta cacgtgaaaa ccctaatact
     5401 caagcaggta ttaaatggtt gattcaaatt tacggtgaaa atgctggaaa tgataaagca
     5461 gaactgctgt ttaaacatgg taaccaagca tttactcgcg ttcaaactaa attagatatt
     5521 gaggcacagc caggaacatt ccctaaagtt atgtatgatc aagtagataa aattaagaaa
     5581 gatttaggtg gttttagacc agatactccg gttctttcct ttacaactga agaattagat
     5641 gttttaacta aatctgaagc aggattaaat actttctttg atgaaaatat tattaaattc
     5701 attgaaggac aaagagatat gagtgagtgg gattcattta tcaatgaagc taaatctaaa
     5761 gacttggata aagttacaaa agtatataat gatgcctaca aacgtgtcaa agatagaatg
     5821 aaatagacta aatggtagct ctctggtttt tcagagagct actactgcct gagggggagt
     5881 aagctttgta tgatgtagta attataggtg caggaagttc gggcgcattg gctgcaattg
     5941 cttcggggcg tctagggtta aaaacttgtc taatagagaa gggaagtaga attggtggag
     6001 ttcctattaa tacactaatg gggtcatttg ctaatctata ttttgatgat tctggtagag
     6061 taaatgcaag taaaattgtt ggggaattaa tagaacgtat tatcaaaaaa ggtggtactg
     6121 tctttaactc tatggaagaa ttgatgaatg taaatgattt ttatcagatt acaattccct
     6181 atcaaccaga agtttatgaa tcggttttaa ctgatatgtt gattgagtct aaagttgata
     6241 ttttactaaa tattgaagtt aataatatta tttatgatag taaaaatatt aaaagtcttg
     6301 aaattttaag taatcaggaa gttaaattga ttgattctaa agtttttatt gatgctacag
     6361 ggaatgcaac aattgcttct gctagtggag ctgatgttta tgaaaaaaat tcttcttacg
     6421 gttgtttaat gagagttgga ggagttgata tctcaaagac tatagaacat attgaaaaaa
     6481 caaagcagtg gaactatata gaaggatata atcagtggtt agaagaagta ttagcaaatc
     6541 gaaagtacag agccactgga gcagttttaa aagatccagt ttcttatgat catgccccta
     6601 tgctttcaaa agacgaccat tttatgaatg atgaaaaatg gaattacatt aaagaaagat
     6661 gggaaaaatt tagatttatt tacactttag aagtatcact atttaggaat gaattaaaaa
     6721 aagctgtaga atctggggat tttaattttg aaatttatca tgatgataaa tctggagtca
     6781 ctatgaatgg cgacggtata agctatggtt catggggtca aaatgtagca ttaattaatg
     6841 ttgcaaaagc atttggattc aatcccaaat atatggaaga tgaatcacat gctaatattc
     6901 tttctagaaa atataattta acatttttat cttttcttaa aaaatatgta ccaggttttg
     6961 aaaattcttt tatccttgat cagggaacta gagctactaa cagatcatgt aggcacattg
     7021 ataattcatc tatgatggac gaaattcttg attttccaat gtatacattt aagactatgt
     7081 atagctatca aactcctaaa gaaataacgt acaaatcaat tgtaggtgga aaattgaata
     7141 atttgtttgt aataggtaaa ggtgcttacc aatccgaaag ttttagatca caaattagtt
     7201 gtatgttaat ggggatatca tcagcagcag cggcaaaaac tattattgaa gataaaagca
     7261 atactctaaa cattaataga gatttgttta aatcgaactt agatatatta tttacatggg
     7321 agttttctaa ttggattact gattaacaaa taataaggga atattaaatg aatgatacta
     7381 ataaaaatca atactttgtt tatgaatttg atactagctt tgtagaaatg tcttattctc
     7441 agttttttga aggatattgt attctttttt caaaagaacc ctatccttct ttatctgata
     7501 tgccaatgga atttagaaaa gaatttttaa tggaaatgag tatattaggt gatgcgatgc
     7561 ttgaagtgtt aaatgcctat agaattaatt atgatatctt aggaaattca acacctgtac
     7621 ttcatgctca tttatttccg agatacatgt gggaagagga agagagaaga aaaactgtag
     7681 ttcatagata tgattcttca gtttttagca atcctgagtt tgaatttact atagaaaagc
     7741 atggaccaat tattaaaaaa ctgaggtctg ctattgatag acattataga gagtatcaac
     7801 aattattaga tgattcaaac tgaactccac attttcgatt agatttaata ccttgtatat
     7861 tacaactagg ttgtggatga tataattttt tgaaaaatat attttaggaa tgacttataa
     7921 agcaattata tcagaggcta ttaaatcaat ggccaaagct tatgctcctt attctgattt
     7981 taaggttgga gctgcgttag taactgaaga taaaaaattt tttctggatg taatatagaa
     8041 aatgctgctt tttctcctac ttgctgtgca gaacgagtat ctttttataa agctgtattt
     8101 aaaggagaac gttcgttttc aagaatatgt attgtaggtg gaaaaaatgg tatcttatca
     8161 tcttttatag caccttgcgg agtgtgtcgc caggtaatga tagaattttg taattctgat
     8221 tcatttgaag ttatattggc tagtgatgtt gatacttata aagtatataa acttaaagaa
     8281 ctactaccag ttagttttaa tcaagaaaat ttataacagg agggaactat ggaattagtt
     8341 gaatttaaaa atggacatgt taatacggtt catgagcata tcgcaataac gaaagtaaaa
     8401 gagtttctaa ataatcatga tataccaaaa gataaaggtg gcatacataa aatttctact
     8461 gatttctttt acaatataat tgatatggaa actacaactg aagagaatag accgtgggaa
     8521 agtcataagg aatattatga tgtccattat ctgttaaatg gagaagaaat aattttatat
     8581 aatttcttgt ctcaaatgga attgtctgaa tataaagtag atgatgattg gcaacaaatg
     8641 aatgggacag ctttatttag tattaaatta aagaaagata tgttactttt gttggaacca
     8701 aacgatgcac ataaaacagg cctattggtt gaagaaccac ttaatattaa gaaagttgtt
     8761 tttaaggtaa aaatttaact gaaagtactt tcggggatta agaattttaa aatatttaag
     8821 aaattgtatt ctaaagttct aaaattatag atatttaatt taaagcttgt taaaatagaa
     8881 tagtaacact catctgcttt caaaaagcat tctagtccat ctccgattaa cgatggactt
     8941 tatcacctcc ttctccagtc cttgtatgac atcttgaagt tgattcatga catcttccaa
     9001 aattcgaaag gctttattct taaatccacg tttacgaatc tctttccaca cttgttcaat
     9061 ggggttcatc tctggtgtgt atggaggaat aaatgcaaaa ccaatattag tcggaatctt
     9121 taagatactt gatttatgcc atatagcatt gtccataacg agtaaaaaat aatcatctgg
     9181 ataagcttgt gaaagctctt ctaaaaagac gttcatccac tcagtattac atccaccagc
     9241 tcttaagaaa aatgattcgc ctgtataggc atcaacagct ccataacaat agcgaaattc
     9301 tcgtatatag tgactatgga catgtggacc tactcctatt ggagaccaac aagatcccag
     9361 tttactgatt ctaccgaaac cagcctcatc ttggtacatc aagcgaacct tatgaaaagg
     9421 tctactggtt ttaaagcgct ttcttgtctt cttgaattga gattttattt ttagacgcga
     9481 caatggtttg agcgtctgct ttcttaggat gttctggacg tggcgtaata tttcgccaac
     9541 catggcgctt caacagttga tagaaggcat cacgtgtgta ggaacgacct aactcctttt
     9601 tataagcctg aaataaggca tcaattgtaa caaattctcc tgcctctgta gccttcaaat
     9661 ggcgggcaag aaaggctttc tcttcctcaa ctgtcatata tgcatggtta cgaccaccac
     9721 gtgtttcttg aaggagagag tcgagtccga actcctcata tttttttaca tttcgccaaa
     9781 tcgttgtttg attacagtct aaaagctcta taatctcttt ataagatttg cccatcagac
     9841 gaaatagaac gatttgaagg cgtttatgat atttagctgt acgagagtct tttaaaagtg
     9901 ttttgatggt ttggatttct tctttagttg atttcatatc actattgtat aatgcttttt
     9961 gattttagtc tagtataaat agcgagaaat atctatccta tcttctagaa tgtcttccaa
    10021 acgaggaaac tctcgtaaac aaagaggttt tagaggccta tttaccgtgg actaaagttg
    10081 tacaagaaaa gtgcaaataa gaaatctcca gattaggaac t
//
LOCUS       DBMVGT010000063        10074 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.063, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000063 DBMVGT010000000
VERSION     DBMVGT010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 10074)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10074)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10074
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.063"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..753)
                     /locus_tag="AC0DU4_001702"
     CDS             complement(<1..753)
                     /locus_tag="AC0DU4_001702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4237627.1"
                     /translation="MKSKKWIFVLCNFLASFFLVACQSGSNGSQSAVEAIKQKGKLVV
                     ATSPDYAPFEFQSLVDGKNQVVGADIDMAQAIADELGVKLEISSMSFDNVLTSLQTGK
                     ADLAVAGISATDERKEVFDFSIPYYENKISFLVRKADVEKYKDLTSLESANIAAQKGT
                     VPESMVKEQLPKAQLTSLTNMGEAVNELQAGKVDAVHMDEPVALSYAAKNAGLAVATV
                     SLKMKDGDANAVALRKNSDDLKEVVDKVIQKLK"
     gene            complement(910..1563)
                     /gene="phoU"
                     /locus_tag="AC0DU4_001703"
     CDS             complement(910..1563)
                     /gene="phoU"
                     /locus_tag="AC0DU4_001703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000946475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA];
                     GO_process: GO:0030643 - intracellular phosphate ion
                     homeostasis [Evidence IEA];
                     GO_process: GO:0045936 - negative regulation of phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HIN4237628.1"
                     /translation="MLRSQFEEDLEKLHNQFYAMGQEVLSQINRTVRAFVTHDRDLAK
                     EVIEDDAEVNEYEVKLEKKSFEMIALQQPVSQDLRTVLTVLKAVSDVERMGDHAVAIA
                     QATIRMKGEERIPAVEEEIKKMGREVKSVVEAALDLYLNGSVDDAYRVASMDEQINRY
                     FETIRDLATEEIKKNPEAIVTGRDYFQVISYLERIGDYAKNICEWVVYFETGKIVEL"
     gene            complement(1575..2333)
                     /gene="pstB"
                     /locus_tag="AC0DU4_001704"
     CDS             complement(1575..2333)
                     /gene="pstB"
                     /locus_tag="AC0DU4_001704"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein
                     PstB"
                     /protein_id="HIN4237629.1"
                     /translation="MTDAILQVSDLSVYYNKKKALNSVSLSFQPKEITALIGPSGSGK
                     STLLKSLNRMGDLNPEVTTTGSVVYNGHNIYSPRTDTVELRKEIGMVFQQPNPFPMTI
                     YENVVYGLRINGIKDKQVLDEAVEKALQGASIWDEVKDRLYDSAIGLSGGQQQRVCVA
                     RVLATSPKIILLDEPTSALDPISAGKIEETLYGLKDKYTMLLVTRSMQQASRISDKTG
                     FFLDGDLIEFNDTKQMFLDPQHKETEDYITGKFG"
     gene            complement(2346..3149)
                     /gene="pstB"
                     /locus_tag="AC0DU4_001705"
     CDS             complement(2346..3149)
                     /gene="pstB"
                     /locus_tag="AC0DU4_001705"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein
                     PstB"
                     /protein_id="HIN4237630.1"
                     /translation="MSTYNWDEKHILTFPEEKVALSTKDVHVYYGKNESIKGIDMQFE
                     RNKITALIGPSGSGKSTYLRSLNRMNDTIDIAKVTGQILYRGIDVNRPEINVYEMRKH
                     IGMVFQRPNPFAKSIYRNITFAHERAGVKDKQVLDEIVETSLRQAALWDQVKDDLHKS
                     ALTLSGGQQQRLCIARAISVKPDILLMDEPASALDPIATMQLEETMFELKKDFTIIIV
                     THNMQQAARASDYTGFFYLGDLIEYDKTATIFQNAKLQSTNDYVSGHFG"
     gene            complement(3160..4044)
                     /gene="pstA"
                     /locus_tag="AC0DU4_001706"
     CDS             complement(3160..4044)
                     /gene="pstA"
                     /locus_tag="AC0DU4_001706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009443446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HIN4237631.1"
                     /translation="MRAKKLDKLATAVLYTIASIIVTILASLILYILVRGLPHISWSF
                     LTGRSSAFQAGGGIGIQLYNSFFLLVITLIISVPLSMGAGIYLAEYAKKGPVTNFVRT
                     CIEILSSLPSVVVGLFGYLIFVVQFEYGFSIISGALALTVFNLPQMTRNVEDSLKHVH
                     HTQREAGLALGISRWETVVHVVIPEALPGIVTGVVLASGRIFGEAAALIYTAGQSAPA
                     LDWSNWNILSVTSPISIFRQAETLAVHIWKVNSEGTIPDGTIVSAGSAAVLLIFILIF
                     NFGARKFGSYLHKKLTAA"
     gene            complement(4034..4951)
                     /gene="pstC"
                     /locus_tag="AC0DU4_001707"
     CDS             complement(4034..4951)
                     /gene="pstC"
                     /locus_tag="AC0DU4_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018378778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA];
                     GO_process: GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HIN4237632.1"
                     /translation="MNQEELAKKMLLPSKNSRLEKLGKGLTFACLSLIVILVAMILVF
                     VAQKGLSTFFVNGVNIFDFLLGGTWNPSSKEFGALPMILGSFIVTILSALIATPFAIG
                     AAVFMTEVSPKGAKILQPAIELLVGIPSVVYGFIGLQVVVPFVRSVFGGTGFGILSGI
                     SVLFVMILPTVTFMTTDSLRAVPRYYREASFAMGATRWQTIWRVILKAARSGIFTAVV
                     FGMARAFGEALAIQMVVGNSAVIPTSLTTPAATLTSILTMGIGNTVMGTVNNNVLWSL
                     ALVLLLMSLVFNSVIKLITKERGKKNYAR"
     gene            complement(4951..5829)
                     /gene="pstS"
                     /locus_tag="AC0DU4_001708"
     CDS             complement(4951..5829)
                     /gene="pstS"
                     /locus_tag="AC0DU4_001708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein PstS"
                     /protein_id="HIN4237633.1"
                     /translation="MKKRKKLALSLIAFWLTACLVGCASWIDRGESITAVGSTALQPL
                     VEVAADEFGTIHVGKTVNVQGGGSGTGLSQVQSGAVDIGNSDVFAEEKDGIDASALVD
                     HKVAVAGLALIVNKEVDVDNLTTEQLRQIFIGEVTNWKEVGGKDLPISVINRAAGSGS
                     RATFDTVIMEGQSAMQSQEQDSNGAVKSIVSKSPGAISYLSLTYIDDSVKSMKLNGYD
                     LSPENISSNNWPLWSYEHMYTLGQPNELAAEFLNFVLSDETQEGIVKGLKYIPIKEMK
                     VEKDAAGTVTVLEGRQ"
     gene            complement(6403..7707)
                     /locus_tag="AC0DU4_001709"
     CDS             complement(6403..7707)
                     /locus_tag="AC0DU4_001709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmF rRNA methyltransferase first C-terminal
                     domain-containing protein"
                     /protein_id="HIN4237634.1"
                     /translation="MQFPEGFVEKYKEILGDEARDFLASFEEEAVSAFRVNPLKEEQL
                     SFSDAITQTPWGHYGKVSGKSPEHATGLVYSQEPAAQMVAQVAQPSPGMKVLDLAAAP
                     GGKSTQLAAYLAGEGLLVSNEISSKRAKILVENMERFGATNVVVTNESADRLVKVFKG
                     YFDLIVLDAPCSGEGMFRKQPDAMDYWSLDYPSQCASLQREILEDAVTMLAEGGRLVY
                     STCTWAPEENEEIVNWLLEEYDFDLLPVEHINGMVAGIDLPETARMYPHQFKGEGQFV
                     AHLQFKGNNPAPKFKASKSNLSREQVALWQEFAQNHLKVNLPGILQTFGDQLYLLPEL
                     LPDLGKLKIARNGLHLGTFKKKRFEPSFALGLALKPSQVEQSVEIGQEAFVKYAAGET
                     VQLAESLPNGWYQVLVKGNGLGFAKVTGNVLKNYFPKGLRFK"
     gene            complement(7708..8481)
                     /locus_tag="AC0DU4_001710"
     CDS             complement(7708..8481)
                     /locus_tag="AC0DU4_001710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="inositol monophosphatase family protein"
                     /protein_id="HIN4237635.1"
                     /translation="MESKFEFAKELVKKAGQYILDHMQEDLRVETKSSSTDLVTRLDK
                     EVQELLVGEILSRYPEDKICAEEGCLRASVQEGKVWVIDPIDGTNNFVAQQEDFAVMM
                     AYFENGQGQFGLIYDVVKGDCYHGGGEFPVCLNDRPLAPFKTKPLGDFLIAGNSGMLE
                     TNEWGLADLSRSVLGVRVYGSAAISFAKILSGRLLTYLTYLQPWDYAAASILGESLGY
                     RVVTLFGEAPDFQTRQPVMMVPLEMQEEIQSYIYERKRT"
     gene            complement(8471..8749)
                     /locus_tag="AC0DU4_001711"
     CDS             complement(8471..8749)
                     /locus_tag="AC0DU4_001711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0223 family protein"
                     /protein_id="HIN4237636.1"
                     /translation="MNKQYSYPLDLSWSTEELASVLSFFNDVEAAYEGKVEAKKLLDS
                     YKGFKAVVPSKSEEKRLGREFETVSGYSLYRAVQAAKEKGEGKISLGK"
     gene            complement(8749..9150)
                     /locus_tag="AC0DU4_001712"
     CDS             complement(8749..9150)
                     /locus_tag="AC0DU4_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007556665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Spx/MgsR family RNA polymerase-binding
                     regulatory protein"
                     /protein_id="HIN4237637.1"
                     /translation="MITLFLSPSCTSCRKAKAWLEKHKVPFVEHNIMTSPLTRKELQH
                     ILSLTENGTDDIISTRSKIFQKLNIDVESISVSELLHLIEQYPSLLRRPIIIDAKRMQ
                     IGFNEDEIRAFLPRSYRKQELKEARMRAGIS"
     gene            complement(9360..9977)
                     /locus_tag="AC0DU4_001713"
     CDS             complement(9360..9977)
                     /locus_tag="AC0DU4_001713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HIN4237638.1"
                     /translation="MKTKLTFWGSMLFLLSLSILLTIYLAWIFYPMEIQWLNLTNRVY
                     LKPETIQYNFHILMNYLTNPFSQVLQMPDFRSSAAGLHHFAVVKNLFHLVQLVALVTL
                     PSFYVFVNRIVKKDFLSLYRKSLLTLVVLPVMIGLGGVLIGFDQFFTLFHQILFVGDD
                     TWLFDPAKDPVIMILPETFFLHAFLLFFALYESFFGYLCLKSRRK"
     gene            complement(9967..>10074)
                     /locus_tag="AC0DU4_001714"
     CDS             complement(9967..>10074)
                     /locus_tag="AC0DU4_001714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD hydrolase-like protein"
                     /protein_id="HIN4237639.1"
                     /translation="LLVTTGFTKAEEVAGLPIAPTHVVSSLAEWDFDEN"
BASE COUNT         3040 a         2330 c         1881 g         2823 t
ORIGIN      
        1 cttaagtttt tggatgacct tgtctaccac ttctttcaaa tcatcactat tttttctaag
       61 agcaacggca ttggcgtcgc cgtccttcat cttcaagctg acagttgcga cagctaagcc
      121 agcgttttta gcagcataac taagtgcaac aggctcatcc atatgaacag catctacttt
      181 tccagcctgc aattcattga ctgcttcacc catattagtt agggaagtta attgagcttt
      241 tggcaattgt tccttgacca ttgattctgg aacagtccct ttttgggctg caatattagc
      301 actttctagg ctagttaaat ccttgtattt ttccacatca gccttacgaa ccaagaaact
      361 aatcttgttt tcatagtatg ggattgaaaa atcaaagact tcttttctct cgtcagtagc
      421 actaattcct gcaactgcta ggtcagcctt accagtttga agactggtca aaacattgtc
      481 aaaactcatg cttgagattt ccaacttaac cccaagttca tcagcgatag cctgagccat
      541 gtcgatgtct gcaccgacta cctggttctt tccatcaacc aatgattgaa attcaaaggg
      601 tgcatagtca ggactggttg ccacaactaa tttccccttt tgcttaatgg cctcaacagc
      661 tgactgagaa ccattagaac ctgactggca agctactaag aagaaacttg caagaaaatt
      721 acataaaaca aatatccatt tttttgattt cataaataaa caacctctct gttaattttg
      781 tataattata acgatatcca agttacttgt caagtgtttt ttaaattttt atctcaaaaa
      841 tatgttttcg ttcaaaaaaa ggagccatca gttgatttca agctcctttt tatacagaat
      901 taaactattt tatagttcga caatcttacc tgtttcaaag tagacaaccc attcacagat
      961 atttttagca tagtcaccga tacgctccaa gtaggaaata acttggaaat aatcacgacc
     1021 cgtaacaatg gcttctggat ttttcttaat ctcttcagtc gcaaggtcac ggatagtttc
     1081 aaaatagcgg ttaatttgct catccatgga ggccacccgg tatgcgtcgt caacagaacc
     1141 attaagataa agatcaagtg ctgcttcaac aacgctttta acttcacgtc ccattttttt
     1201 aatttcttcc tctacagctg ggatgcgttc ttcccccttc atacggatgg ttgcctgggc
     1261 aatggctaca gcgtgatccc ccatacgctc cacatctgat acagccttaa ggacagtcaa
     1321 gactgtacgc aaatcttgag agactggttg ttggagtgcg atcatttcaa atgatttctt
     1381 ttccagtttc acttcgtatt catttacttc tgcatcatct tcgatgacct cttttgccag
     1441 gtcacggtca tgcgtgacaa aagcacgtac cgtacgattg atttgtgaga gcacttcttg
     1501 tcccatagcg tagaactggt tatgtaattt ctctaaatct tcttcaaatt gagatcgtaa
     1561 catctttcat ctccttatcc aaattttcct gtaatatagt cttccgtttc cttgtgttgg
     1621 ggatcaagga acatctgctt ggtatcatta aattcaatca aatctccatc taggaaaaat
     1681 cctgtcttat cagagatacg tgaagcttgc tgcatggaac gggttaccag aagcatggtg
     1741 tacttgtctt ttagaccata caaggtttcc tcaattttac cagctgaaat cggatccaaa
     1801 gccgaagttg gctcatccaa gaggatgatt ttaggactag ttgccaagac acgggccacg
     1861 cagacacgct gctgttgacc acctgacaat ccaatagctg aatcatatag acgatccttg
     1921 acctcatccc agatagaggc accttgcaag gctttttcta cggcttcatc cagaacctgc
     1981 ttatccttaa ttccattgat acgaagcccg tagacaacat tctcatagat agtcataggg
     2041 aaaggattag gttgttggaa aaccattccg atttccttac gtaattcaac cgtatctgta
     2101 cgcggactgt agatgttgtg accattgtac accacggatc cagttgtggt cacctctgga
     2161 ttgagatctc ccatgcggtt gagagacttg aggagggttg acttccctga tccagatgga
     2221 ccaatcaagg ctgtaatttc cttaggttgg aaagataggg aaacactatt caaagccttc
     2281 tttttattat aataaacgga caggtctgat acctgtaaaa tcgcatctgt catacggttt
     2341 cctttctaac caaagtgacc agatacatag tcattggtgg actgtagctt ggcattttgg
     2401 aaaatagttg cagtcttgtc atactcaatc aaatcaccca agtaaaagaa gcctgtatag
     2461 tcacttgcac gagcagcctg ctgcatatta tgcgttacaa tgatgatggt aaagtctttc
     2521 ttgagctcaa acatggtctc ttctagttgc atggtcgcaa tcggatccaa ggctgaagct
     2581 ggctcatcca ttaagaggat atctggctta acagagatgg cacgagcgat acagagacgt
     2641 tgttgctgac cacctgataa ggtcaaggct gacttgtgga gatcgtcttt aacctgatcc
     2701 cagagggcag cctgacgaag ggaggtttct acgatttcat ctaggacttg cttatcctta
     2761 actccagcac gttcatgcgc aaaggtaata ttacggtaaa ttgacttagc aaatggattg
     2821 gggcgttgaa aaaccattcc aatgtgttta cgcatttcat aaacgttgat ttctggacgg
     2881 ttgacatcaa ttccacgata gagaatctgc ccagttactt tagcaatatc aatggtatca
     2941 ttcatgcgat tgagactgcg taagtaggta gatttccccg atcccgacgg accaatcaaa
     3001 gctgtaattt tatttctttc aaattgcata tcaatcccct taatggattc atttttacca
     3061 tagtaaacat ggacatcctt agtagaaagg gctacttttt cttcaggaaa ggtaaggata
     3121 tgcttctcat cccagttata tgttgacatg gcttctcctt taggcagcgg ttaatttctt
     3181 gtgtagatag cttccgaact tacgagctcc aaagttaaaa atcaggataa agatcaggag
     3241 cacagcggca gaacctgctg atacaatggt tccatctgga atagtgcctt cactattgac
     3301 tttccagata tggacagcca aggtttctgc ttgacggaag atagagatgg ggctagtcac
     3361 actgaggata ttccagttag accagtcaag agctggcgcc gattgccctg ctgtatagat
     3421 cagagctgca gcttcgccaa agatacgacc agatgccaag acgacacccg ttacaatacc
     3481 tggaagcgct tctggaataa caacatgaac cactgtctcc cagcgagaaa tcccaagagc
     3541 cagaccagcc tcacgttggg tatggtgaac gtgtttcaaa ctatcctcta cattacgcgt
     3601 catctgaggc aagttaaaga ctgtcaaggc caaggcacct gaaatgattg aaaatccata
     3661 ctcaaactgg actacaaaga tcaagtaacc aaagagaccc accaccactg atggtaaaga
     3721 ggacaagatt tcaatacaag tccgcacaaa gttggtaaca ggaccttttt tagcatattc
     3781 agccaagtaa atcccagctc ccatagaaag aggtacagaa ataatcaagg taatgaccaa
     3841 taggaaaaag gaattgtaaa gctgaatgcc aatcccacca cctgcttgaa aagcagaaga
     3901 ccttccagtc aagaaagacc aagagatatg gggcaagccc cgaaccaaga tatagagaat
     3961 caaggaagcc aagattgtca caatgatgct agcaatcgta tagaggacag ctgttgcaag
     4021 tttatctaat ttcttagcgc gcataatttt tctttcctct ttctttcgta atcaatttaa
     4081 tcacactgtt aaaaactaaa ctcatcaaga gcagtaccaa ggccagtgac cagagaacat
     4141 tattatttac agttcccatg acagtgttcc caattcccat agttaatata gaagttaaag
     4201 ttgcagctgg tgtggtcaag gaagttggga taacagctga gtttccgaca accatctgga
     4261 tagctaaagc ctcaccaaag gcacgcgcca tcccaaagac cactgcagtg aaaataccag
     4321 aacgggccgc cttcaagatc acacgccaga tagtctgcca gcgagtggct cccatagcga
     4381 aactggcttc acgataataa cgaggaaccg cacgcaagct atccgttgtc ataaaggtta
     4441 cggtcggcaa aatcatgaca aagaggacgg aaatccctga caaaatccca aaaccagtcc
     4501 caccaaagac actgcgaaca aagggaacga cgacttgcaa gccaataaat ccatacacta
     4561 ctgaaggaat cccaaccagg agttcaatag ctggttgcaa aatcttcgcc ccttttggtg
     4621 atacttcggt cataaaaact gctgcaccaa tagcaaaggg tgttgcgata agggctgaga
     4681 gaatggtaac gataaaggaa cccaaaatca taggaagggc accaaattct ttactagaag
     4741 gattccaagt tcctcccaaa agaaagtcaa agatattcac accattgaca aagaaggtcg
     4801 acaagccttt ttgcgctacg aaaaccaaaa tcatggccac aaggatgact atcaaagaaa
     4861 gacaggcaaa ggtcaaacct tttcctaatt tctccagacg agaattcttt gatggaagca
     4921 acattttctt agctaattct tcttgattca ttattgtctc ccttccaaca ctgtcacagt
     4981 tccggcagca tctttttcaa ccttcatttc cttaatcgga atatacttca atcctttgac
     5041 aatcccttct tgggtctcat ccgagagaac aaaattgaga aattctgcag ccaactcatt
     5101 gggctgcccc aatgtataca tatgctcata agaccacaag ggccaattat tgctacttat
     5161 attttctgga cttaagtcat agccattcaa cttcatgctt ttgaccgaat catctatata
     5221 ggtaagagat aaataagaga tagctcctgg actttttgat acgattgatt ttaccgctcc
     5281 atttgaatcc tgctcctgac tttgcatggc agactgacct tccataatga cagtatcaaa
     5341 ggtagcacga gaaccagagc cggctgcccg attgataaca gagatgggta agtccttacc
     5401 accaacctct ttccaattgg ttacctcacc tatgaagatt tgacgaagtt gctctgtcgt
     5461 taggttatca acatcaacct ccttattgac aatcagagcc aagccagcta ccgcgacctt
     5521 gtggtcaaca agagcagaag catcaattcc gtctttttcc tcagcaaata catctgagtt
     5581 tcctatatca actgccccag actgaacctg ggacaagcct gtaccagaac ctcccccttg
     5641 gacattgacc gtttttccaa catggatcgt gccaaattca tctgccgcta cttcaaccaa
     5701 gggttgcaag gcagttgagc caacagccgt tatggattct ccacgatcaa tccagctagc
     5761 acagcctact aaacaagccg tcagccaaaa agcgataaga gacagagcaa gcttttttct
     5821 ttttttcact gtttttctcc tcgaaaataa ttatgaatac tgtgaatttt ttaagtagtt
     5881 ctttatgagt tgacgcatga attcttacca aatttctgcg caattgatta tttatataat
     5941 ataggctata ttactctttc ctaacctcct tttttcatat gtggataaaa tctcttgtct
     6001 atcccttccc ccattgtcac ccattataat catttcgtgt ctctttttcc cctttttaat
     6061 gcaagggaaa ttactctcct cagatgataa tccaaaagct agaaaggtat ctcaaacctc
     6121 tctactctcc cagactagtt tacaactaaa aggaaaagat tctattttat gagaaatcta
     6181 gtttacaagc ggtaagaacg ctaataacta aacttcttgt actctttgaa aatctcttca
     6241 aaccagtgtt ttgagctatc tatggctagc ttcctagttt gctctttgat tttcatcgag
     6301 tagtaaaact acatgtgatg gcaatcaaga tatcaagaat catcctacta aaaaaatcca
     6361 tactttcact ataacataga ataagatatt tgactagcat tttcatttga atctgaggcc
     6421 ttttggaaaa taatttttca aaacatttcc agtaaccttt gcaaagccca agccattgcc
     6481 tttaaccaaa acttggtacc aaccatttgg cagactttct gccagctgaa cggtttctcc
     6541 agccgcatac ttgacaaacg cttcttggcc aatttcaacc gactgttcga cctgactcgg
     6601 tttcaaggct aaaccaagag cgaaactggg ctcaaagcgt ttcttcttaa aagtgcccag
     6661 atgcagtcca ttgcgagcaa tcttgagctt ccctaaatct ggcaaaagtt ctggcaagag
     6721 ataaagctgg tctccaaaag tctgcaagat acccggtaga ttgaccttca aatggttttg
     6781 ggcaaattcc tgccacaagg caacttgttc acggctgagg ttactcttac ttgccttaaa
     6841 tttaggagct ggattgttac ccttaaactg tagatgggca acaaactgac cctctccctt
     6901 aaactgatga gggtacatcc gagccgtttc tggcaggtca ataccagcta ccattccatt
     6961 gatatgctct actggcaaca agtcaaaatc atactcttcc agcaaccaat tgacaatctc
     7021 ttcgttttcc tcgggtgccc aggtacaggt cgaataaacc agacgaccac cttcagctaa
     7081 catggtcact gcatcctcca gaatttctct ttgcaagcta gcacattgac tcggataatc
     7141 taagctccaa tagtccatag catcaggttg cttacgaaac attccttcac cagagcaagg
     7201 ggcatcaaga acgattaagt caaaatagcc tttaaagacc ttgaccaagc ggtcggcaga
     7261 ttcattggtc accacgacat ttgtcgctcc aaaacgctcc atgttttcaa ccaaaatctt
     7321 agcccgtttg cttgaaattt cattggaaac aagtagcccc tcacctgcta gataggctgc
     7381 cagttgagtt gatttgcccc ccggtgcagc agccaagtcc aagaccttca taccaggact
     7441 gggttgggct acttgagcca ccatttgagc agcaggttct tgcgaataaa ctaaacctgt
     7501 agcatgctca ggcgatttcc ctgaaacctt cccatagtgg ccccaagggg tttgagtaat
     7561 ggcatcagaa aaggaaagtt gctcttcttt taagggattg acccgaaagg ccgaaaccgc
     7621 ttcctcctca aaagaggcaa gaaaatctct tgcctcatct cctagtatct ctttatattt
     7681 ttcaacaaat ccttctggaa attgcattta agttcttttc ctttcgtaaa tataggactg
     7741 aatttcctcc tgcatctcaa gaggcaccat catgaccggc tgtctggttt gaaaatcagg
     7801 agcttcacca aaaagggtca caacccgata gcccagactt tcccctaaaa tactagctgc
     7861 ggcataatcc catggttgca gataagtgag ataggtcaac aaacgccctg acaaaatctt
     7921 ggcaaaacta atggccgcac ttccatagac acgaacacca agaaccgatc ggctcaaatc
     7981 agccagcccc cattcattgg tttccagcat accactattc cctgcaatga gaaaatctcc
     8041 aagtggttta gttttaaaag gagctagggg cctatcattt agacaaactg gaaattcccc
     8101 accaccgtgg taacaatccc ctttgaccac atcataaatc agaccaaact gtccctgacc
     8161 attttcaaaa taagccatca taacagcaaa atcttcctgc tgggctacaa aattattggt
     8221 accatcaatg ggatcaatga cccaaacctt gccctcttga accgaggctc gcagacaacc
     8281 ttcttcagca caaatcttat cctcaggata acgggacaaa atctcaccaa ccaagagttc
     8341 ctgaacttct ttgtccagtc tggtcaccaa atctgttgaa gaggacttgg tttcaacacg
     8401 caagtcttcc tgcatatggt caagaatgta ctggcctgct ttcttaacaa gctctttagc
     8461 aaattcaaat ttactttcca agagaaatct ttccttcccc tttttctttg gcagcctgaa
     8521 ctgctcggta aagtgaatag ccactaaccg tttcaaattc tcgtcccaaa cgtttctctt
     8581 cgctcttgct tggcacgacc gctttgaatc ccttatagga gtccagtaac tttttagcct
     8641 ctactttgcc ttcataggca gcttcaacat cattaaaaaa agaaagcact gaagcaagtt
     8701 cttcagtgct ccacgacaaa tctagtgggt aactatactg tttgttcatt aactaatacc
     8761 agctctcatt cttgcttctt ttagttcttg cttacgataa ctacgaggga gaaaagcacg
     8821 aatctcatct tcattaaaac cgatttgcat acgcttggca tcaataataa ttggacgacg
     8881 caaaagacta ggatactgct caatcaaatg aagcaattcc gataccgaaa tactctctac
     8941 atcaatattc aatttttgaa aaatttttga acgagttgaa atgatgtcat cagtaccatt
     9001 ttcggtcaag gaaaggatgt gttgcaattc ttttcttgtt aaaggactgg tcataatatt
     9061 gtgttccaca aagggaacct tatgtttttc taaccaggcc ttagccttac gacatgatgt
     9121 acagctcggt gatagaaata gtgtaatcat gcttttctct tcttatctat actttgctac
     9181 ttctattata caaaaaaata aggcgcttga ctagggattt ttagaaaaaa agcctatttt
     9241 ttcaagaaaa ataggctgtt tgcgaacgat tgacacaatt ggatttggtt aattcactct
     9301 taacgatggt tttaaacgat atatattttt atatatgcaa attaaaaaca tctttcattt
     9361 cacttcctac gacttttcag acacagatac ccaaagaagc tttcatagag ggcaaaaaag
     9421 aggaggaagg catgaagaaa gaaggtctct ggcaaaatca taataacagg atccttggct
     9481 ggatcaaaaa gccaggtatc atctcccaca aagagaattt gatggaaaag agtaaagaat
     9541 tggtcaaaac caatcaaaac tcccccaagt ccaatcatca caggtaagac tactagagtc
     9601 aggagacttt ttcgataaag agacaaaaag tcctttttca caatcctatt gacaaagaca
     9661 tagaaacttg gcagtgtcac tagagctact agctgaacca aatgaaagag attcttgacc
     9721 actgcgaaat ggtgcagacc agctgctgac gaacgaaaat caggcatctg taagacctga
     9781 ctaaaaggat tggtcagata attcatcaag atatgaaaat tgtattgaat ggtttctggt
     9841 tttagataga ctcgattcgt taagtttagc cactgaatct ccataggata gaaaatccaa
     9901 gccagataaa tggtcagaag gattgagagg gagaggagaa agagcataga gccccaaaag
     9961 gtcaatttag ttttcatcaa aatcccactc cgcaaggcta gaaaccacat gtgtcggtgc
    10021 gattggcagg ccagctactt cttctgcctt ggtaaaacct gtcgtcacca agag
//
LOCUS       DBMVGT010000064         9975 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.064, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000064 DBMVGT010000000
VERSION     DBMVGT010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 9975)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9975)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9975
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.064"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(62..1003)
                     /locus_tag="AC0DU4_001715"
     CDS             complement(62..1003)
                     /locus_tag="AC0DU4_001715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HIN4237640.1"
                     /translation="MKQAKRIKRWRYYLRRFAYQIKILRVLQSISREKYDEKISASLV
                     YGFLSAVAVNFFFQPGHVYSSGATGLAQIISALSNHWFGFHIPISLSFYAINFPLMVL
                     AWYQIGHKFTVFTFITVSMSSFFIQFVPVATLTEDPIINALFGGVVMGLGIGFALRNN
                     ISSGGTDIVSLTIRKKTGKNVGSISFLVNGTIMLIAGLTFGWKYALYSMITIFVSSRV
                     TDAVFTKQKRMQAMIVTNHPEKVIEKIHKKLHRGATMIHDAEGTYNHERKAVLITVIT
                     RAEFNEFKQIMTQVDPSSFVSVSENVHILGRFVEIDN"
     gene            complement(981..2744)
                     /gene="aspS"
                     /locus_tag="AC0DU4_001716"
     CDS             complement(981..2744)
                     /gene="aspS"
                     /locus_tag="AC0DU4_001716"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016874 - ligase activity [Evidence IEA];
                     GO_process: GO:0006418 - tRNA aminoacylation for protein
                     translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HIN4237641.1"
                     /translation="MKRSMYAGRVREEHIGQEITLKGWVGRRRDLGGLIFIDLRDREG
                     IMQLVINPEKVSAEVMATAESLRSEFVIEVTGQVAAREQANDKLPTGAVELNVTALIV
                     LNTAKTTPFEIKDGIEANDDTRLRYRYLDLRRPEMLENLKLRAKVTHSIRNYLDELEF
                     IDVETPFLSKSTPEGARDYLVPSRVNKGHFYALPQSPQITKQLLMNAGFDRYYQIVKC
                     FRDEDLRGDRQPEFTQVDLETSFLTEKEIQDITEGLIARVMKETKGIEVTLPFPRMKY
                     DDAMALYGSDKPDTRFDMLLQDLTEVVKGVDFKVFSEAPAVKAIVVKGAADNYSRKDI
                     DKMTEVAKQYGAKGLAWVKVVDGELNGPVAKFLTGIQEELTTALALEDKDLVLFVADT
                     LEVANATLGALRGRIAKELGLIDNDKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPQ
                     EETAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKDLQERMFKALGFSAEEANDQ
                     FGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGEENIREVIAFPKNNKATDPMTQAPSTV
                     ALKQLEELSLQVEEDETSKTN"
     gene            complement(2863..3009)
                     /locus_tag="AC0DU4_001717"
     CDS             complement(2863..3009)
                     /locus_tag="AC0DU4_001717"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237642.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDRTDGVSNHTYGKATLTWFEEI
                     FEEY"
     gene            complement(3051..3281)
                     /locus_tag="AC0DU4_001718"
     CDS             complement(3051..3281)
                     /locus_tag="AC0DU4_001718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000832182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237643.1"
                     /translation="MKRVILLAVIQAVVLFFIIGALAYAFKGDFFYNYLAVVFAPIAG
                     VLRFGTAYITEIVLPRKAAEIAEKRKAGKNSK"
     gene            complement(3299..3940)
                     /locus_tag="AC0DU4_001719"
     CDS             complement(3299..3940)
                     /locus_tag="AC0DU4_001719"
                     /EC_number="3.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA];
                     GO_process: GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane glutamic
                     endopeptidase"
                     /protein_id="HIN4237644.1"
                     /translation="MKLLKNLGWILLALLSFFFIYGFIQGLATASLALGASPYAVTLL
                     YVVLAGVYVYGIYKWYQKAPVYIEKSGFNRFIWLPALVWFLSLVVQFFLPDDPSVNQQ
                     IATDLTLSQPLFSFFAVVIFAPLTEEIVFRGMLARYLFPKQDNSKRTLIFLLVSSLLF
                     ALIHFPGDVQQFFVYFSLGFSLGLAYISRKGLVYSISLHALNNLVGFLMILML"
     gene            complement(3952..4686)
                     /locus_tag="AC0DU4_001720"
     CDS             complement(3952..4686)
                     /locus_tag="AC0DU4_001720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3169 family protein"
                     /protein_id="HIN4237645.1"
                     /translation="MKKKRRLLFLMSIVLGGFLGMFVGMFKARVESHEIILDVKALMP
                     WISAICLLIGFISMFLTFNFLKKSRKFHSLYQEEMDDDLNETYYVQMYRNLEFGTIAF
                     NITGVAIPLAIFISLSEVIILHTNPQTFFLSFLLFVVFLVAQKSLFKTIAIVRQFDLE
                     FFATPKDVLNYINSYDEGERQANLEQSFRILFQLHQYVLPALYIFLIIISFLTGEIQL
                     LAFLLVGAIHVYINVMQLPMVKRYFK"
     gene            complement(4689..4886)
                     /locus_tag="AC0DU4_001721"
     CDS             complement(4689..4886)
                     /locus_tag="AC0DU4_001721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001046145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237646.1"
                     /translation="MNKYKVIYYVVVIALLVSVFLLIGMDLSWFNPYQSDQFVWVYFA
                     LIPVTEWIEKKSKNLASEKGE"
     gene            complement(4886..5092)
                     /locus_tag="AC0DU4_001722"
     CDS             complement(4886..5092)
                     /locus_tag="AC0DU4_001722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HIN4237647.1"
                     /translation="MQLKNRLKELRARDGLNQTDLAKLAGVSRQTISLLERDEYTPSI
                     IIALKISQIFNETVESVFRLEEDE"
     gene            complement(5102..5569)
                     /locus_tag="AC0DU4_001723"
     CDS             complement(5102..5569)
                     /locus_tag="AC0DU4_001723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237648.1"
                     /translation="MIDKVVRNLLLTFFFCKMTKIINFLTTIIVKKKKMCYNEFKLRN
                     RKQKGVIMWVLVFILFMIFFYSNNSKKIKKLENKIKKLERKEKGNAEMSRLLQEMIGK
                     EPIITGVYIGPDNWEVVDVDEEWVKLRSVDKKGKEKFKLQRIEDIQTVEFDGE"
     gene            complement(5569..5760)
                     /locus_tag="AC0DU4_001724"
     CDS             complement(5569..5760)
                     /locus_tag="AC0DU4_001724"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237649.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDRTDEVSSKHGFEVVDETDEVS
                     NYTYGKVKLTWFEEILEEY"
     gene            complement(5757..7046)
                     /gene="hisS"
                     /locus_tag="AC0DU4_001725"
     CDS             complement(5757..7046)
                     /gene="hisS"
                     /locus_tag="AC0DU4_001725"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HIN4237650.1"
                     /translation="MKLQKPKGTQDILPAESAKWQYVEGFAREIFKRYNYAEVRTPIF
                     EHYEVISRSVGDTTDIVTKEMYDFYDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQK
                     PSKFYYMGPMFRYERPQAGRLRQFHQIGVECFGSSNPATDVETIVMAAHFLKEIGIQG
                     VKLHLNTLGNPESRAAYRQALIDYLTPLKETLSKDSQRRLEENPLRVLDSKEKEDKVA
                     VENAPSILDFLDEESQTHFDAVRQMLENLGVDYIIDTNMVRGLDYYNHTIFEFITEIE
                     GNDLTVCAGGRYDGLVAYFGGPETAGFGFGLGVERLLLILEKQGVALPIENALDVYIA
                     VLGDGANVKALELVQALRQQGFKAERDYLNRKLKAQFKSADVFAAKTLITLGESEVES
                     GQVTVKNNQTREEVQVSLETISQNFSEIFEKLGFYTQ"
     gene            complement(7124..8371)
                     /locus_tag="AC0DU4_001726"
     CDS             complement(7124..8371)
                     /locus_tag="AC0DU4_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter"
                     /protein_id="HIN4237651.1"
                     /translation="MKLLFRNPAYRILTLSRFFNAFGASIFNLVFIVYASTLSQASFA
                     VAMANIVMILPTFFTVFAGIRADYTRDKVKWMVYSGLFQAVLFFLAALVVQQASLFAF
                     SSLCLINVISDIISDFAGGLRMPLIKEKVAEDDLMEAYSFSQFITYISAIGGQAFGVW
                     LLALSVNNFSLVAGINACFFLVSATILFLGKSKLSLSMSSADGENLKNEKLSIKDQFL
                     TIYRNLRLVFLKSGQKNFGFMLFAVLLINSLGGALGGIYNIFFLSHSLLNFSYTEALF
                     INQFCVLVAIIISSLTGNAYFGKQSLPRLMMWATVGLSLVGLANLFNQVVLGLLFLFF
                     TLYVSGKVQPKISAMLMKNLAPEVLARTSNFLDLLFTLSIPVGTACFSLVAVWNIQLT
                     WMLFVGLSLLAIFLTILNLKNDI"
     gene            complement(8562..9413)
                     /gene="rgg"
                     /locus_tag="AC0DU4_001727"
     CDS             complement(8562..9413)
                     /gene="rgg"
                     /locus_tag="AC0DU4_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434947.1"
                     /note="Rgg, as the term is used in Streptococcus
                     pneumoniae, is the lone quorum-sensing system
                     transcriptional regulator related to proteins Rgg1, Rgg2,
                     Rgg3, and Rgg4 of Streptococcus pyogenes; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system transcriptional regulator
                     Rgg"
                     /protein_id="HIN4237652.1"
                     /translation="MEQIGKVFRQLRESRNISLRQATGGQFSPSMLSRFETGQSELLV
                     EKFLFALENISASVEEILFLARGFQYDTDSELRKEITDVLEPKNIAPLEDLYRREYQK
                     HAHSHNKQKHILNAIIIKSYMKSIDERVELTAEEGKVLHDYLFSTEIWGIYELNLFSV
                     SSPFLSVSLFTRYVREMVRKSDFLMEMSGNRNLFHTILLNGFLASIECEEFTNAYYFK
                     RVIEEHFYKENETYFRIVYLWAEGLLDSKQGRVKEGQKKMEDAVRIFEMLGCNKSAEY
                     YRNTTEC"
     gene            9537..9878
                     /locus_tag="AC0DU4_001728"
     CDS             9537..9878
                     /locus_tag="AC0DU4_001728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003080443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HIN4237653.1"
                     /translation="MRDDIKINDRALALQDQIIEKLEKVFDTDVELDVYNLGLIYEIN
                     LDETGLCKIVMTFTDTACDCAESLPIEIVAGLKQIEGIEDIKVEVTWSPAWKITRISR
                     YGRIALGLPPR"
BASE COUNT         3118 a         2174 c         1877 g         2806 t
ORIGIN      
        1 acatacatac ggtaaggcga cgctgacgtg gtttgaagag attttcgaag agtattaatc
       61 actaattatc tatctcaaca aatcttccta gaatatgaac attttccgag acagagacaa
      121 aggagcttgg atccacttgt gtcataatct gtttaaattc attaaactct gcacgtgtaa
      181 tgacagtgat taaaactgcc tttctctcgt gattataggt tccttctgca tcatggatca
      241 tggttgctcc gcggtgcaat tttttatgga ttttttcaat taccttctct ggatgatttg
      301 tcacaatcat ggcctgcata cgcttttgct tagtaaagac tgcgtctgtc acacggctag
      361 agacaaagat ggtaatcata gaataaagag cgtatttcca accaaaggtc aaacctgcta
      421 tcagcatgat agttccattt accaagaaag aaatactacc aacattctta cccgttttct
      481 tgcgaatagt caggctgacg atatccgtcc caccactgga gatattgttt cgaagagcaa
      541 aaccaatccc caaacccata acaacacccc caaaaagggc attgataatg ggatcctccg
      601 tcaaggttgc cacagggaca aactggataa agaaggaact catagatacc gtgataaagg
      661 taaagacggt gaacttatgg ccaatctgat accaagctaa gaccatcaaa gggaagttaa
      721 tggcgtagaa gcttagcgaa atcggaatat gaaaaccaaa ccagtgatta ctcaaggcag
      781 agataatctg tgccagacct gttgcaccac tcgaatacac atgccctggt tggaaaaaga
      841 aattaactgc tactgctgat aaaaaaccat agaccagaga ggccgaaatc ttctcatcat
      901 acttttctcg agagatactt tgtaagacac gtaaaatttt tatctgataa gcaaagcggc
      961 gcagataata gcgccaccgc ttaattcgtt ttgcttgttt catcttcttc tacttgtaag
     1021 ctgagttcct ctagttgttt gagagcgact gttgatggag cttgtgtcat tgggtcagtt
     1081 gccttgttgt tcttaggaaa ggcaatgact tcacggatat tttcttctcc agcaagcaac
     1141 atgacaaaac ggtcaagccc gatagccaaa ccaccgtgtg gtgggaaacc atagtccatg
     1201 gcttcaagaa ggaaaccaaa ctggtcattg gcttcttcag ctgagaaacc aagagccttg
     1261 aacatgcgtt cttgaaggtc tttttggttg atacgaaggc taccaccacc aagctcataa
     1321 ccgttcaaga cgatatcgta agcaatggca cgaaccttag ccaaatcacc ttctaattcg
     1381 tgagcagtct cttcctgtgg aagtgtgaat ggatggtggg cgctcatgta gcggccttct
     1441 tcttcagacc attcaaacat cggccagtca accacccaaa ggaagttgaa cttatcatta
     1501 tcaatcaagc caagctcttt agcaatacgt ccacgaaggg cacccagtgt tgcattagcc
     1561 acttcaagcg tatccgccac aaagagaacc aagtccttat cttcaagagc aagcgctgtt
     1621 gtcaattctt cttggatacc agtcaagaac ttggcaactg gtccgtttaa ttctccatca
     1681 accaccttga cccaagcaag acctttggca ccatactgtt tggctacttc cgtcatcttg
     1741 tcgatgtctt tacgtgaata gttgtccgca gctcctttga ccacaatcgc ttttacagca
     1801 ggtgcttctg aaaagacttt aaagtctaca cctttgacca cttctgtcaa gtcctgaagc
     1861 aacatgtcaa aacgagtatc tggcttgtca gaaccgtaaa gagccatagc atcatcgtat
     1921 ttcatacgag ggaacggtag cgttacttcg atgccttttg tttccttcat cacgcgcgcg
     1981 atcaagcctt ctgtaatatc ttggatttct ttctcagtaa ggaaggacgt ttccaagtcg
     2041 acctgagtaa attcaggctg gcggtctcca cgcaagtcct cgtcacggaa acatttaacg
     2101 atttggtagt aacggtcaaa accagcattc atcaagagct gtttcgtgat ttgtggactt
     2161 tgaggaagag cgtaaaaatg ccccttatta acacgagacg gcactaaata atcacgcgcc
     2221 ccttcaggcg ttgacttaga aaggaatggt gtctccacgt cgataaactc caactcatcc
     2281 aaatagttgc ggatagagtg ggtcaccttg gcacgaagtt taagattttc caacatttct
     2341 ggacgacgaa ggtcaaggta acggtaacgc aaacgtgtat cgtcatttgc ctcaatgcca
     2401 tccttaatct caaatggtgt tgtcttagct gtgttaagca caataagagc tgtcacgttt
     2461 aactcaaccg caccagttgg caacttatca ttggcttgct cacgcgcagc gacctgacca
     2521 gtcacctcaa taacaaattc gctacgaagg ctttcagctg ttgccataac ctctgcagat
     2581 actttttcag ggttgataac caactgcatg attccttcac ggtcacgaag atcgataaag
     2641 atcaaaccac caaggtcacg acgacggcca acccatcctt tcaaggttat ttcttgtccg
     2701 atgtgttcct cacgaacacg accagcatac atactacgtt tcattatttc tctcctcttt
     2761 tattctgtta ctattttacc ataaaagcgc aggctcttca tgaaaatcat cagaaaagtt
     2821 tgccagtctt taaaagtcag gtgaaagccc taaaaattag cgctaatact cttcgaaaat
     2881 ctcttcaaac cacgtcagcg tcgccttacc gtaggtatgg ttactgactc cgtcagttct
     2941 atccacaacc tcaaaacagt gttttgagca acctgcggct agcttcctag tttgctcttt
     3001 gattttcatt gagtataata caaaaatccg atgaacttca ccggactctt ttattttgaa
     3061 tttttgcctg ctttacgctt ttcagcgatt tcggctgcct ttcgaggcaa gacaatttcc
     3121 gttatgtaag ccgtcccaaa acgcagtaca cctgcaatag gagcaaagac aactgctaga
     3181 tagttataga agaaatcgcc tttgaaggca taagctagcg ctccaatgat gaaaaataga
     3241 acgactgcct gaatcactgc taataaaatt actcgtttca tgtgacctcc tgactctatt
     3301 atagcatgag aatcatcaaa aagccgacta aattattcaa agcgtgaaga gaaatactgt
     3361 agaccagacc ttttctgcta atgtaagcca aacccaaact aaaaccaagg ctaaaataga
     3421 caaaaaattg ttgcacatca cctggaaaat gaatcaaggc aaatagaaga ctagatacca
     3481 gaagaaaaat cagggttcgt ttactattgt cctgcttagg aaagagatag cgtgctaaca
     3541 tccctctaaa aacaatctct tccgtcaaag gagcaaaaat aaccacagca aagaatgaga
     3601 aaagtggttg agacaaggtc aagtctgtcg ctatttgctg atttactgaa ggatcatctg
     3661 gcaagaagaa ttgaacgacc agagataaga accaaaccaa ggcaggaagc caaataaatc
     3721 ggttaaagcc gctcttctca atataaacag gagctttctg ataccatttg taaatgccgt
     3781 acacatatac tccagccaag accacataga gtagagtaac agcatagggt gaagcgccta
     3841 aagcaagcga cgcagtcgcg agcccctgaa taaagccata gataaagaaa aaggatagaa
     3901 gggctagaag aatccagcca aggtttttaa gtaatttcat agataactcc tttatttgaa
     3961 ataacgtttt accataggta actgcatcac attgatataa acatggatgg ctcctacaag
     4021 caagaaagct agtaactgaa tctctcctgt caagaaagaa atgataataa gaaaaatata
     4081 taaggctggt aagacatatt ggtgtaattg gaataaaatt cgaaaactct gttccaaatt
     4141 agcctgacgc tccccttcat cataagaatt tatatagttc aagacatcct ttggtgtagc
     4201 gaaaaattcc aaatcaaact gacgaacaat cgcaatggtt ttaaaaagag atttttgagc
     4261 gactaagaat accacaaaga gtaagaaaga aaggaaaaat gtttgagggt ttgtatgcaa
     4321 tataatcacc tcacttaatg aaataaaaat agccaatgga atcgctacac ctgtaatatt
     4381 aaaagcaatg gttccaaact caagattccg atacatttgc acataatagg tttcattcag
     4441 atcgtcatcc atttcctctt gatacaagga atgaaatttt ctgcttttct ttaagaaatt
     4501 gaaagtcaaa aacatactaa tgaaacctat cagtaaacaa atagctgata tccatggcat
     4561 caaggctttt acatctaaaa taatttcgtg ggattcgaca cgtgccttaa acatccctac
     4621 aaacatgccc aagaaccccc ccaagacaat agacatcaaa aataacaatc tacgtttctt
     4681 tttcatattc attctccttt ttcacttgct agatttttgg atttcttttc aatccattca
     4741 gttactggga tgagagcaaa gtagacccaa acaaattggt cgctttgata gggattaaac
     4801 cagcttaggt ccatcccaat cagtagaaat acgctgacta ataaagctat gaccactaca
     4861 taataaatca ctttatactt gttcatcact cgtcctcctc caaacgaaat accgattcga
     4921 ctgtttcgtt gaaaatttga gatattttca gggcaatgat aatggatggg gtgtactcat
     4981 cccgttctag taggctaatg gtctgtctgg aaacccctgc cagtttggct aggtcggttt
     5041 gattgagacc atcgcgagct cgaagctctt ttagacgatt ttttagttgc atgttacaca
     5101 cctactctcc gtcaaattca acggtttgga tatcttcaat acgttgcaac ttgaattttt
     5161 ctttcccctt tttatcaaca ctacgtagtt tgacccattc ctcgtcaaca tccacaactt
     5221 cccagttatc tggcccaata tacactcccg ttataattgg ttcctttcca atcatttctt
     5281 gcaataatct cgacatttct gcgtttcctt tctcttttcg ctcaagtttt ttgattttat
     5341 tctctagttt cttgattttt ttagaattat tagaataaaa gaaaatcata aatagtataa
     5401 atactagtac ccacattata actcctttct gcttcctatt tcttaacttg aattcattgt
     5461 aacacatctt tttctttttg acaattatag ttgtcaaaaa gtttatgatt tttgtcattt
     5521 tgcaaaagaa aaaggtcagg agtaagttcc tgaccacttt atctatcatt aatactcttc
     5581 taaaatctct tcaaaccacg tcagcttcac cttgccgtag gtatagttac tgacttcgtc
     5641 agtttcatct acaacctcaa aaccatgttt tgagctgact tcgtcagttc tatccacaac
     5701 ctcaaaacag tgttttgagc aacctgcggc tagcttccta gtttgctctt tgattttcat
     5761 tgagtataaa atcctagttt ttcaaagatt tctgagaagt tttggctgat tgtctcaagt
     5821 gacacttgca cttcttctcg ggtttggttg ttcttgaccg tcacttgtcc gctttcgact
     5881 tcgctctctc ctagggtgat gagggtctta gccgcaaaga catctgctga cttgaactga
     5941 gctttgagct tacggttgag gtaatcacgc tctgctttga aaccttgttg gcgaagagct
     6001 tggactagtt ctagggcttt gacatttgct ccatcaccca agactgcgat atagacatct
     6061 agggcgtttt cgatagggag ggccacgcct tgtttttcaa ggatgagaag caggcgctct
     6121 acaccaagcc caaaaccaaa tccagcagtt tcagggcctc caaagtaagc aaccaaacca
     6181 tcgtagcgac cacccgcaca gactgtcaag tcattgccct caatctctgt gataaactcg
     6241 aaaatggtgt ggttgtagta gtccagacca cgcaccatat tggtatcgat gatgtaatct
     6301 actccaagat tttccaacat ctgacgcaca gcatcaaaat gagtttggct ttcttcatca
     6361 agaaagtcca agatagacgg cgcattctct actgccacct tgtcttcttt ttccttagag
     6421 tccaagacac gaagaggatt ttcctccaag cgacgttggc tatccttaga caaggtctcc
     6481 ttgagcggtg tcaaatagtc aatcaaggct tggcggtagg ctgcacggct ctcaggattt
     6541 ccaagagtgt tgaggtgcaa tttgacacct tgaataccga tttccttcaa aaaatgggct
     6601 gccataacga ttgtttccac atcggtagct ggattgctag agccaaaaca ctcaacacca
     6661 atctggtgga attggcgcaa gcgccctgcc tgtggacgct cataacggaa cataggtccc
     6721 atgtagtaga acttgcttgg cttttgcact tctggggcga agagtttatt ttccacatag
     6781 gaacggacaa cgggcgcagt tccttctgga cggagggtaa tatggcggtc acccttgtca
     6841 tagaaatcgt acatttcctt ggttacgata tccgttgtat ctccgacaga gcggctgata
     6901 acctcgtaat gctcgaaaat aggcgtacgc acttctgcgt agttgtagcg cttgaaaatc
     6961 tcacgggcaa agccctcaac gtactgccac ttagcagact cagcaggtaa aatatcctgc
     7021 gttccttttg gtttttgtaa tttcataggg aatcctcttt aaacttaata gtcttatttt
     7081 accataaata gagggattaa aacagtgaga aaaaaattag gatttagata tcatttttga
     7141 gattaagaat tgtcaaaaaa atagctagca aggaaagacc aacaaatagc atccaagtca
     7201 actgtatatt ccatacggct actagtgaaa aacaagctgt tcccacaggt atggataagg
     7261 taaacaatag atctaaaaaa ttactagtac gagctagaac ctctggagct agatttttca
     7321 tgagcatggc actaatcttt ggttgaactt taccagacac atacagagta aagaagagaa
     7381 atagcaaacc aagcacgact tgattgaata aattagccaa accaactaga ctaagtccta
     7441 cagtcgccca catcatcaat ctaggcaagg actgcttccc aaaataagca ttgcccgtaa
     7501 ggctactgat gatgattgct actaaaacac agaattgatt gataaatagt gcctctgtat
     7561 aagaaaaatt caagagagaa tggctcaaaa agaagatatt ataaattcca cccaaagcgc
     7621 cacccaagga attaataagc aagacagcaa agagcataaa accaaagttt ttctgcccac
     7681 ttttaagaaa aacgagacgt aaatttcggt aaattgttag gaactggtct ttgatagaaa
     7741 gcttctcatt ttttaagttt tcaccatcag cagatgacat tgacaggctc aatttgcttt
     7801 ttcctaaaaa gaggatagtg gctgatacta ggaaaaagca ggcattgatt cccgcaacga
     7861 gagaaaaatt gttgaccgat agagctaaga gccagactcc gaaagcttga ccaccaatag
     7921 ctgaaatata ggtgatgaac tgtgaaaaag aataagcctc catcagatca tcttcagcta
     7981 ctttttcctt aataagaggc atacgcaggc cacctgcaaa atcactgatg atatcactaa
     8041 tgacattgat caaacacagg ctagaaaagg caaagagact agcttgctga acaactaggg
     8101 ctgctagaaa aaatagaacc gcctgaaaca aaccgctata gaccatccat ttgaccttgt
     8161 ccctcgtgta atctgcccga atccctgcaa aaactgtaaa gaaggtcgga agaatcatga
     8221 caatattcgc catagcaaca gcaaaagatg cttgtgacaa ggtcgatgca tagacgataa
     8281 agaccaggtt gaaaatcgaa gcaccaaaag cattgaagaa gcgtgataaa gtcaaaattc
     8341 tataagctgg atttctaaac aatagtttca tagataatct ccctccttgt tctaagttct
     8401 acatcaagaa tagctttagt atagcactta tgaatttgcg aaacgattct tttgaatata
     8461 tgcaacaaac aaaatgagca aaaaaacgat agaacttttg taatgacctg agagagggta
     8521 acagttctat cgcttcaaat tttttcttgg tttgcagata ctcaacattc ggtcgtattt
     8581 ctatagtatt cggcagattt attacagcca agcatctcaa aaatacggac agcatcctcc
     8641 atctttttct ggccttcctt gactctacct tgcttgctat caaggagacc ttctgcccac
     8701 agataaacaa ttcggaaata ggtctcattt tccttgtaga aatgctcttc gataacacgt
     8761 ttaaaataat aggcattggt aaattcttca cactcaatac tagctaaaaa gccattcaat
     8821 agtatagtat gaaaaaggtt tcgattgcca gacatttcca ttagaaaatc agatttacgt
     8881 accatttctc gtacatatct agtaaaaaga gaaacagata aaaatggaga actgactgaa
     8941 aataaattga gttcatagat tccccagatc tcggtagaaa acaaataatc atgaaggact
     9001 tttccttcct ctgctgttaa ctctaccctt tcatctatgc tcttcatata agacttgata
     9061 ataatggcat ttagaatatg tttctgtttg ttgtgagaat gggcatgctt ttgatactcc
     9121 ctgcgatata agtcctcaag aggtgctata ttctttggtt ccaagacatc tgtaatttct
     9181 tttctcaact cagaatctgt atcatactgg aaacctctcg ccagaaagag gatctcctcc
     9241 acactggcag atatattttc cagagcaaat agaaactttt ccaccaaaag ctcactctga
     9301 cctgtttcaa aacgggacaa catagacggc gaaaattgtc ctccggttgc ttgtctcagt
     9361 gagatatttc ttgactctcg taattgtcta aagacttttc caatctgctc catagacttc
     9421 cccttgattc cgtattttct tcattttatc atatttttca gaaaattcat caaaaacttg
     9481 ccaaattgtc agaattatga gaaaatagag gatatttatc acgtggaggg actgctatga
     9541 gagacgatat caaaatcaat gaccgtgctt tggccttgca agaccaaatt atcgaaaaac
     9601 tagagaaagt ttttgataca gatgtggaat tggatgttta caatctaggt ctgatttatg
     9661 aaatcaatct ggatgaaacg gggctctgca agattgtcat gaccttcacc gatactgcct
     9721 gtgattgcgc cgaaagcctg cctattgaaa tcgtggcagg tctgaaacaa atcgagggta
     9781 tcgaagatat caaggttgaa gttacctggt cgcctgcttg gaaaatcaca cgaatcagtc
     9841 gctatggccg tattgccctt ggactaccac ctcgttaagc aggccaatca cttttaaaga
     9901 tgaaaaaagc aagccgaaaa tggcttgctt tttgatactc aatgaaaatc aaagggcaaa
     9961 ctagaaaact agccg
//
LOCUS       DBMVGT010000065         9808 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.065, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000065 DBMVGT010000000
VERSION     DBMVGT010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 9808)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9808)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9808
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.065"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            311..6745
                     /locus_tag="AC0DU4_001729"
     CDS             311..6745
                     /locus_tag="AC0DU4_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750042.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008236 - serine-type peptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HIN4237654.1"
                     /translation="MKKSTVLSLTTAAVILAAYAPNEVVLADTSSSEDALSISDKEKV
                     VVDKETENKEKHKDIHNAIETSKDTEEKKTTIIEEKEVVSKNPVIDTKTSNEEAKIKE
                     ENSNQSQGDHTDSFVNKNTENPKKEDKVVYIAEFKDKESGEKAIKGLSNLKNTKVLYT
                     YDRIFNGSAIETTPDNLDKIKQIEGISSIERAQKVQPMMNHARKEIGVEEAIDYLKSI
                     NAPFGKNFDGRGMVISNIDTGTDYRHKAMRIDDDAKASMRFKKEDLKGTDKNYWLSDK
                     IPHAFNYYNGGKITVEKYDDGRDYFDPHGMHIAGILAGNDTEQDIKNFNGIDGIAPNA
                     QIFSYKMYSDAGSGFAGDETMFHAIEDSIKHNVDVVSVSSGFTGTGLVGEKYWQAIRA
                     LRKAGIPMVVATGNYATSASSSSWDLVANNHLKMTDTGNVTRTAAHEDAIAVASAKNQ
                     TVEFDKVNIGGESFKYRNIGAFFDKNKITTNEDGTKAPSKLKFVYIGKGQDQDLIGLD
                     LRGKIAVMDRIYTKDLKNAFKKAMDKGARAIMVVNTVNYYNRDNWTELPAMGYEADEG
                     TKSQVFSISGDDGVKLWNMINPDKKTEVKRNNKEDFKDKLEQYYPIDMESFNSNKPNV
                     GDEKEIDFKFAPDTDKELYKEDIIVPAGSTSWGPRIDLLLKPDVSAPGKNIKSTLNVI
                     NGKSTYGYMSGTSMATPIVAASTVLIRPKLKEMLERPVLKNLKGDDKIDLTSLTKIAL
                     QNTARPMMDATSWKEKSQYFASPRQQGAGLINVANALRNEVVATFKNTDSKGLVNSYG
                     SISLKEIKGDKKYFTIKLHNTSNRPLTFKVSASAITTDSLTDRLKLDETYKDEKSPDG
                     KQIVPEIHPEKVKGANITFEHDTFTIGANSSFDLNAVINVGEAKNKNKFVESFIHFES
                     VEEMEALNSNGKKINFQPSLSMPLMGFAGNWNHEPILDKWAWEEGSRSKTLGGYDDDG
                     KPKIPGTLNKGIGGEHGIDKFNPAGVIQNRKDKNTTSLDQNPELFAFNNQGINAPSSS
                     GSKIANIYPLDSNGNPQDAQLERGLTPSPLVLRSAEEGLISIVNTNKEGENQRDLKVI
                     SREHFIRGILNSKSNDAKGIKSSKLKVWGDLKWDGLIYNPRGREENAPESKDNQDPAT
                     KIRGQFEPIAEGQYFYKFKYRLTKDYPWQVSYIPVKIDNTAPKIVSVDFSNPEKIKLI
                     TKDTYHKVKDQYKNETLFARDQKEHPEKFDEIANEVWYAGAALVNEDGEVEKNLEVTY
                     AGEGQGRNRKLDKDGNTIYEIKGAGDLRGKIIEVIALDGSSNFTKIHRIKFADQADEK
                     GMISYYLVDPDKDASKYEKLGEISEDKLKNAKSPEENTNNNQAKDEDSKPDEKSSVEG
                     EASLEINKTISTIREFENKDLKKLIKKKFREVDDFTSETGKRIEEYDYKYDDKRNIIA
                     YDDGSALQYETEKFDEIKSKIYGVLSPSKDGHFEILGKISNVSKNAKVYYGNSYKSIE
                     IKATKYDSHSKTMIFDLYANINDIVDGLAFAGDMRLFVKDDNQIKAETKIRMPEKNKE
                     TKAEYPYVSSYGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNIILRKG
                     YALKVTTYNPGKTDMLEGNGVYSKEDIAKIQKANPNLRVLSETTIYADSRNVEDGRST
                     QAVLMSALDGFNIIRYQVFTFKMNDKGEAIDKDGNLVTDSSKLVLFGKDDKEYTGEDK
                     SNVEAIKEDGSMLFIDTKPVNLSMDKNYFNPSKSNKIYVRNPEFYLRGKISDKGGFNW
                     ELRVNESVVDNYLIYGDLHIDNTRDFNIKLNVKDGDIMDWGMKDYKANGFPDKVTDMD
                     GNVYLQTGYSDLNAKAVGVHYQFLYDNVKPEVNIDPKGNTSIEYADGKSVVFNINDKR
                     NNGFDGEIQEQHIYVNGKEYTSFDDIKQITDKTLNIKIVVKDFARNTTVKEFILNKDT
                     GEVSELKPHRVTVTIQNGKEMSSTIVSEEDFILPVYKGELEKGYQFDGWEISGFEGKK
                     DAGYVINLSKDTFIKPVFKKIEEKKEEENKPTFDVSKKKDNPQVNHSQLNESHRKEDL
                     QREDHSQKSDSTKDVTATVLDKNNISSKSTTNNPNKLPKTGTASGAQTLLAAGIMFIV
                     GIFLGLKKKNQD"
     gene            7370..7846
                     /locus_tag="AC0DU4_001730"
     CDS             7370..7846
                     /locus_tag="AC0DU4_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HIN4237655.1"
                     /translation="MVLDYFFDKNLVFCLEADNQEQLFDQVATLLEEREIVTPTYREA
                     LITREKSFPTGLDMEFLGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIAPDK
                     EVEVSLLFFIINNSSSSQTNILAQLMDFFTGNGHLEDLSKISEPEKLYAYIAETTA"
     gene            7884..8189
                     /locus_tag="AC0DU4_001731"
     CDS             7884..8189
                     /locus_tag="AC0DU4_001731"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4237656.1"
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVN
                     EDLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFRIPAMSAPVFDNIEAAIKEHGLS"
     gene            8237..9712
                     /locus_tag="AC0DU4_001732"
     CDS             8237..9712
                     /locus_tag="AC0DU4_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HIN4237657.1"
                     /translation="MDAIFDLIGKVFNPILEMGGPVIMLIILTVLALLFGVKFSKALE
                     GGIKLAIALTGIGAIIGMLNGAFSASLAKFVENTGIQLSITDVGWAPLATITWGSAWT
                     LYFLLIMLIVNVVMLAMKKTDTLDVDIFDIWHLSITGLLIKWYADNNGVSQGVSLFIA
                     TAAIVLVGVLKIINSDLMKPTFDDLLNAPSSSPMTSTHMNYMMNPVIMVLDKIFEKFF
                     PGLDKYDFDAAKLNKKIGFWGSKFFIGFILGIVIGIMGTPHPIAGVADADKWRLVIKG
                     WLSLGLTAGVSLELFSLIGSWFIAAVEPLSQGITNVATKRLQGRKFNIGLDWPFIAGR
                     AEIWACANVLAPIMLIEAVLLSKVGNGILPLAGIIAMGVTPALLVVTRGKLLRMIIFG
                     TLLLPLFLLSGTLIAPFATELAKGVGAFPEGVSQTQLITHSTLEGPIEKLLGWTIGNT
                     TTGDIKAILGAVVFLVFYIGIFAWYRKQMIKRNEEYAAKAK"
BASE COUNT         3622 a         1472 c         1891 g         2823 t
ORIGIN      
        1 cgtcagttcc atctacaacc tcaaaacagt gttttgagca acctgcggct agtttcctag
       61 tttgctcttt gattttcatt gagtactaat cttatttttt aacgtgtgct aaaaaataaa
      121 ttaatgcatg ttaatttttt tgacttaaat ttttttaaat gatatactgt ttttatagag
      181 agataacaat tatatataaa tgtactactc tatttcctag ataatactta gtaaaacttt
      241 ttataacaaa ggctagcaaa gttaaagttt attatctatt ggaagttaaa taaatatgta
      301 aggaattaaa atgaaaaaaa gcacagtatt gtcattaact acagctgcag ttattttagc
      361 agcctatgcc cctaatgagg tagtcttagc agacacatct agctctgaag atgctttaag
      421 catctctgat aaagaaaaag tagtagtaga taaggaaaca gaaaataaag agaaacataa
      481 agatattcat aatgctatag aaacttcaaa ggatactgaa gaaaagaaaa caacaattat
      541 tgaggaaaaa gaagttgtta gtaaaaatcc tgtaatagac actaaaacta gcaatgaaga
      601 agcaaaaatc aaagaagaaa attccaatca atcccaagga gatcatacgg actcatttgt
      661 gaataaaaac acagaaaatc ccaaaaaaga agataaagtt gtctatattg ctgaatttaa
      721 agataaagaa tctggagaaa aagcaatcaa gggactatca aatcttaaga atacaaaagt
      781 tttatatact tatgatagaa tttttaacgg tagtgccata gaaacaactc cagataactt
      841 ggacaaaatt aaacaaatag aaggtatttc atcgattgaa agggcacaaa aagtccaacc
      901 catgatgaat catgccagaa aggaaattgg agttgaggaa gctattgatt acctaaagtc
      961 tatcaatgct ccgtttggga aaaattttga tggtagaggt atggtcattt caaatatcga
     1021 tactggaaca gattatagac ataaggctat gagaatcgat gatgatgcca aagcctcaat
     1081 gagatttaaa aaagaagact taaaaggaac tgataaaaat tattggttga gtgataaaat
     1141 ccctcatgcg ttcaattatt ataatggtgg caaaatcact gtagaaaaat atgatgatgg
     1201 aagggattat tttgacccac atgggatgca tattgcaggg attcttgctg gaaatgatac
     1261 tgaacaagat atcaaaaact ttaacggcat agatggaatt gcacctaatg cacaaatttt
     1321 ctcttacaaa atgtattctg acgcaggatc tgggtttgcg ggtgatgaaa caatgtttca
     1381 tgctattgaa gattctatca aacacaacgt tgatgttgtt tcggtatcat ctggttttac
     1441 aggaacaggt cttgtaggtg agaaatattg gcaagctatt cgggcattaa gaaaagcagg
     1501 cattccaatg gttgtcgcta cgggtaacta tgcgacttct gcttcaagtt cttcatggga
     1561 tttagtagca aataatcatc tgaaaatgac cgacactgga aatgtaacac gaactgcagc
     1621 acatgaggat gcgatagcgg tcgcttctgc taaaaatcaa acagttgagt ttgataaagt
     1681 taacataggt ggagaaagtt ttaaatacag aaatataggg gcctttttcg ataagaataa
     1741 aatcacaaca aatgaagatg gaacaaaagc tcctagtaaa ttaaaatttg tatatatagg
     1801 caaggggcaa gaccaagatt tgataggttt ggatcttagg ggcaaaattg cagtaatgga
     1861 tagaatttat acaaaggatt taaaaaatgc ttttaaaaaa gctatggata agggtgcacg
     1921 cgccattatg gttgtaaata ctgtaaatta ctacaataga gataattgga cagagcttcc
     1981 agctatggga tatgaagcgg atgaaggtac taaaagtcaa gtgttttcaa tttcaggaga
     2041 tgatggtgta aagctatgga acatgattaa tcctgataaa aaaactgaag tcaaaagaaa
     2101 taataaagaa gattttaaag ataaattgga gcaatactat ccaattgata tggaaagttt
     2161 taattccaac aaaccgaatg taggtgacga aaaagagatt gactttaagt ttgcacctga
     2221 cacagacaaa gaactctata aagaagatat catcgttcca gcaggatcca catcttgggg
     2281 gccaagaata gatttacttt taaaacccga tgtttcagca cctggtaaaa atattaaatc
     2341 tacgcttaat gttattaatg gcaaatcaac ttatggctat atgtcaggaa ctagtatggc
     2401 gactccaatc gtggcagctt ctactgtttt gattagaccg aaattaaagg aaatgcttga
     2461 aagacctgta ttgaaaaatc ttaagggaga tgacaaaata gatcttacaa gtcttacaaa
     2521 aattgcccta caaaatactg ctcgacctat gatggatgca acttcttgga aagaaaaaag
     2581 tcaatacttt gcatcaccta gacaacaggg agcaggccta attaatgtgg ccaatgcttt
     2641 gagaaatgaa gttgtagcaa ctttcaaaaa cactgattct aaaggtttgg taaactcata
     2701 tggttccatt tctcttaaag aaataaaagg tgataaaaaa tactttacaa tcaagcttca
     2761 caatacatca aacagacctt tgacttttaa agtttcagca tcagcgataa ctacagattc
     2821 tctaactgac agattaaaac ttgatgaaac atataaagat gaaaaatctc cagatggtaa
     2881 gcaaattgtt ccagaaattc acccagaaaa agtcaaagga gcaaatatca catttgagca
     2941 tgatactttc actataggcg caaattctag ctttgatttg aatgcggtta taaatgttgg
     3001 agaggccaaa aacaaaaata aatttgtaga atcatttatt cattttgagt cagtggaaga
     3061 aatggaagct ctaaactcca acgggaagaa aataaacttc caaccttctt tgtcgatgcc
     3121 tctaatggga tttgctggga attggaacca cgaaccaatc cttgataaat gggcttggga
     3181 agaagggtca agatcaaaaa cactgggagg ttatgatgat gatggtaaac cgaaaattcc
     3241 aggaacctta aataagggaa ttggtggaga acatggtata gataaattta atccagcagg
     3301 agttatacaa aatagaaaag ataaaaatac aacatccctg gatcaaaatc cagaattatt
     3361 tgctttcaat aaccaaggga tcaacgctcc atcatcaagt ggttctaaga ttgctaacat
     3421 ttatccttta gattcaaatg gaaatcctca agatgctcaa cttgaaagag gattaacacc
     3481 ttctccactt gtattaagaa gtgcagaaga aggattgatt tcaatagtaa atacaaataa
     3541 agagggagaa aatcaaagag acttaaaagt catttcgaga gaacacttta ttagaggaat
     3601 tttaaattct aaaagcaatg atgcaaaggg aatcaaatca tctaaactaa aagtttgggg
     3661 tgacttgaag tgggatggac tcatctataa tcctagaggt agagaagaaa atgcaccaga
     3721 aagtaaggat aatcaagatc ctgctactaa gataagaggt caatttgaac cgattgcgga
     3781 aggtcaatat ttctataaat ttaaatatag attaactaaa gattacccat ggcaggtttc
     3841 ctatattcct gtaaaaattg ataacaccgc ccctaagatt gtttcggttg atttttcaaa
     3901 tcctgaaaaa attaagttga ttacaaagga tacttatcat aaggtaaaag atcagtataa
     3961 gaatgaaacg ctatttgcga gagatcaaaa agaacatcct gaaaaatttg acgagattgc
     4021 gaacgaagtt tggtatgctg gcgccgctct tgttaatgaa gatggagagg ttgaaaaaaa
     4081 tcttgaagta acttacgcag gtgagggtca aggaagaaat agaaaacttg acaaagacgg
     4141 aaataccatt tatgaaatta aaggtgcagg agatttaaga ggaaaaatca ttgaagtcat
     4201 tgcattagat ggttctagca atttcacaaa gattcataga attaaatttg ctgatcaggc
     4261 tgatgaaaag gggatgattt cttattacct agtagatcct gacaaagatg cttctaaata
     4321 tgaaaaactt ggtgaaattt ctgaagataa actcaaaaat gcaaagagcc cagaggaaaa
     4381 taccaataat aatcaagcta aggatgaaga ttcaaaacca gatgaaaaaa gttcagttga
     4441 gggagaagct agccttgaaa taaataaaac tatttcaaca attagagagt ttgaaaataa
     4501 agacctaaag aaactcatta aaaagaaatt tagagaagtt gatgatttta caagtgaaac
     4561 tggtaagaga atagaggaat acgattataa atacgatgat aagagaaata ttattgctta
     4621 tgacgatggt agtgccttac aatatgaaac tgaaaaattt gacgaaataa aatcaaaaat
     4681 ttatggtgtt ctaagcccat ctaaagatgg acactttgaa attcttggaa agataagcaa
     4741 tgtttctaaa aatgccaagg tatattatgg aaatagctat aaatcgatag aaatcaaagc
     4801 gactaagtat gattcacatt caaaaacgat gatatttgat ttatacgcta atattaatga
     4861 tattgtagat ggattagctt ttgctggaga tatgagatta tttgttaaag atgacaatca
     4921 aataaaagct gaaactaaga ttagaatgcc tgaaaaaaat aaggaaacta aagcagaata
     4981 tccctatgta tcaagttatg ggaatgtaat cgaattagga gaaggagatc tttcaaagaa
     5041 caaaccagac aatttaacta aaatggaatc tggtaaaatc tattctgatt cagaaaaaca
     5101 acaatatctg ttaaaggata acatcattct aagaaaaggc tatgcactaa aagtgactac
     5161 ctataatcct ggaaaaacgg atatgttaga aggaaatgga gtctatagca aggaagatat
     5221 agcaaaaata caaaaggcca atcctaatct aagagtcctt tcagaaacaa caatttatgc
     5281 tgatagtaga aatgttgaag atggaagaag tacccaagct gtattaatgt cggctttgga
     5341 cggctttaac attataaggt atcaagtgtt tacatttaaa atgaacgata aaggggaagc
     5401 tatcgataaa gacggaaatc ttgtgacaga ttcttctaaa cttgtattat ttggtaagga
     5461 tgataaagaa tacactggag aggataagtc caatgtagaa gctataaaag aagatggctc
     5521 catgttattt attgatacca aaccagtaaa cctttcaatg gataagaact actttaatcc
     5581 atctaaatct aataaaattt atgtacgaaa tccagaattt tatttaagag gtaagatttc
     5641 tgataagggt ggttttaact gggaattgag agttaatgaa tcggttgtag ataattattt
     5701 aatctacgga gatttacaca ttgataacac tagagatttt aatattaagc tgaatgttaa
     5761 agacggtgac atcatggact ggggaatgaa agactataaa gcaaacggat ttccagataa
     5821 ggtaacagat atggatggaa atgtttatct tcaaactggc tatagcgatt tgaatgctaa
     5881 agcagttgga gtccactatc agtttttata tgataatgtt aaacctgaag taaacattga
     5941 tcctaaggga aatactagta tcgaatatgc tgatggaaaa tctgtagtct ttaacatcaa
     6001 tgataaaaga aataatggat tcgatggtga gattcaagaa caacatattt atgtaaatgg
     6061 aaaagaatat acatcatttg atgatattaa acaaataaca gacaagacac taaacattaa
     6121 gattgttgta aaagattttg caagaaatac aaccgtaaaa gaattcattt taaataaaga
     6181 tacgggagag gtaagtgaat taaaacctca tagggtaact gtgaccattc aaaatggaaa
     6241 agaaatgagt tcaacgatag tgtcggaaga agattttatt ttacctgttt ataagggtga
     6301 attagaaaaa ggataccaat ttgatggttg ggaaatttct ggtttcgaag gtaaaaaaga
     6361 cgctggctat gttattaatc tatcaaaaga tacctttata aaacctgtat tcaagaaaat
     6421 agaggagaaa aaggaggaag agaataaacc tacttttgat gtatcgaaaa agaaagataa
     6481 cccacaagta aatcatagtc aattaaatga aagtcacaga aaagaggatt tacaaagaga
     6541 agatcattca caaaaatctg attcaactaa ggatgttaca gctacagttc ttgataaaaa
     6601 caatatcagt agtaaatcaa ctactaacaa tcctaataag ttgccaaaaa ctggaacagc
     6661 aagcggagcc cagacactat tagctgccgg aataatgttt atagtaggaa tttttcttgg
     6721 attgaagaaa aaaaatcaag attaagacaa aagctataga aaaaaatggt ttatgtactg
     6781 agattagata gtgaggtgat gacatagttt tgtgaaaaca gccatttata actcaattat
     6841 ttagtttact tcactattga tactatttgg agttattaat ggacttagtt tagataacta
     6901 atgaattgat tgaaagggtt agtattgaca atattggtca tattgattag aaaatagagt
     6961 ctatcaaaat ttaaaggcta atagaggtga tgagacaatt tcaaggaatt aagtagcgtt
     7021 tggttgctta attccttttt atttggaagg aagtttttcg taaccgccca ataacgaagt
     7081 ctattggacg gttacgatat gatcactgac ttcgtcagtc ttatctacaa cctcaaaact
     7141 gtgttttgag caacctgcgg ctagcttcct agtttactct ttgattttca ttgagtatta
     7201 gaacagaaaa aatgcttgga gtatttgttt gtgtgtttat ttttatataa caaactataa
     7261 acaaaaaaaa atataaaaaa agagacaaaa aagaacagaa agtaattgac aacggtttca
     7321 tatagtgtta tacttatggc ataaagttaa tggaaagaag ggaaaactta tggtattaga
     7381 ttatttcttt gacaaaaacc ttgtgttttg cttagaagcg gataatcaag aacaactctt
     7441 tgatcaggtt gcaactttat tggaagaacg agaaattgtc actccaactt atcgtgaagc
     7501 cttgatcacg cgtgaaaagt catttccaac tggtttagat atggaatttc taggaaagga
     7561 cttgccaaat gtagcgattc ctcatacaga tattgttcat aatctagctg agaaagtggt
     7621 ggttgttcga ttagaaaaac cagtaacttt tcacaatatg atagctcctg ataaggaagt
     7681 agaagtatcc ttgctcttct ttatcatcaa taactcaagt tcaagtcaaa caaatattct
     7741 ggctcagttg atggactttt tcacaggaaa tggacatctt gaagacctat caaaaatttc
     7801 cgaaccagaa aaactttatg cttacattgc tgaaacaacc gcttaatctt gtctattaaa
     7861 aaataaaatc ggaggaaatc taaatgatta aaattcttgc tgcctgcggt gcaggtgtta
     7921 actcaagtca ccaaattaaa agtgctctag aagaagaact ttcaaaccgt ggttatgatg
     7981 ttcactgtga tgcagtcatg gtgaaagatg taaacgaaga ccttatgaaa ggttacgata
     8041 tctttacacc aatcgctgca acagaccttg gttttgaacc aggtatccca gttatcgaag
     8101 ctggaccaat cttattccgt atcccagcaa tgagcgctcc agtatttgac aatattgaag
     8161 cagctattaa agaacatgga ttaagctaat tctaatttgt taacattcat ataacataaa
     8221 aaagggagga actgttatgg atgcaatctt tgacctaatc ggaaaggttt tcaatcccat
     8281 cttagaaatg ggtggacctg tcatcatgtt gatcattttg acagtattgg ctttactttt
     8341 tggagtgaaa ttctccaaag cgcttgaagg tggtatcaaa cttgccatcg ctcttacagg
     8401 tatcggtgct atcatcggta tgctaaatgg tgctttctca gcatcacttg caaaattcgt
     8461 tgaaaacact ggtatccaat tgagtattac agacgttggt tgggcaccac tcgcaacaat
     8521 cacttggggt tctgcttgga cactatactt cttgctcatc atgttgattg tcaacgtagt
     8581 gatgcttgct atgaagaaaa ccgatacact tgatgtcgat atctttgata tctggcactt
     8641 gtctatcaca ggtctcttga ttaaatggta tgctgataac aatggtgtga gtcaaggggt
     8701 ttcactcttt attgctacag cagctatcgt ccttgtcggt gtgttgaaaa ttatcaactc
     8761 tgacttgatg aaacctacat ttgatgacct tcttaacgcc ccaagttcat caccaatgac
     8821 atcaactcac atgaactaca tgatgaaccc agttatcatg gttttggata agatttttga
     8881 aaaattcttc ccaggccttg ataaatatga ctttgatgct gctaaattga acaagaaaat
     8941 cggtttctgg ggatctaaat tcttcatcgg tttcatcctt ggtatcgtta tcggtattat
     9001 gggaactcca catccaattg caggtgttgc agatgcagat aaatggcgtc ttgttatcaa
     9061 aggatggttg tctcttggtt tgactgccgg tgtatctttg gaactcttct cacttatcgg
     9121 ttcatggttc atcgcagccg tagaaccact atcacaaggt attacaaacg ttgctactaa
     9181 acgtcttcaa ggacgtaaat tcaatatcgg tcttgactgg ccattcatcg ctggtcgtgc
     9241 tgaaatctgg gcttgtgcca acgtacttgc accaatcatg ttgattgaag cagtgcttct
     9301 ttcaaaagtt ggaaatggta tcttgccact tgcaggtatc atcgctatgg gtgttactcc
     9361 agctctcttg gttgtaactc gtggtaaatt gctccgtatg attatcttcg gaacactctt
     9421 gttgccactc ttccttcttt caggtacact tattgcacca tttgcaacag aacttgctaa
     9481 aggtgtaggt gccttcccag aaggtgtgag ccaaactcaa ttgattactc actctactct
     9541 tgaaggacca atcgaaaaac ttcttggttg gacaattggt aacactacaa ctggtgatat
     9601 caaagcaatc cttggtgcag tagtcttcct tgtattctat atcggtatct ttgcttggta
     9661 cagaaaacaa atgatcaaac gtaacgaaga gtacgcagca aaagcaaaat aatgcgctcc
     9721 tataaaatat aaacttaatg aaaatcaaag agcaaactag gaagctagcc gcaggttgct
     9781 caaaacacag ttttgaggtt gtagataa
//
LOCUS       DBMVGT010000066         8996 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.066, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000066 DBMVGT010000000
VERSION     DBMVGT010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 8996)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8996)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8996
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.066"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1317
                     /locus_tag="AC0DU4_001733"
     CDS             <1..1317
                     /locus_tag="AC0DU4_001733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose PTS transporter subunit IIA"
                     /protein_id="HIN4237658.1"
                     /translation="ANWVWNFGYFTVNRIGYQAQVIPALLAGLSLSYLEIFWRKHIPE
                     VISMIFVPFLSLIPALILAHTVLGPIGWTIGQGLSSVVLAGLTGPVKWLFGAIFGALY
                     APFVITGLHHMTNAIDTQLIADAGGTALWPMIALSNIAQGSAVFAYYFMHRHDEREAQ
                     VSLPATISAYLGVTEPALFGVNVKYIYPFVAGMTGSALAGMLSVTFNVTAASIGIGGL
                     PGILSIQPQYMLPFAGTMLVAIVVPMLLTFFFRKAGLFTKTEGDTNLQAEFVAQEEAE
                     FVNHEPVELTSVEIISPLTGQVKELSQATNPIFASGVMGQGLVIEPSQGELTSPVNGT
                     VTVLFPTKHAIGIVSDEGVELLIHIGMDTVGLDGKGFESLVVQGDHVTVGQQLIRFDM
                     DVIKAAGLVTETPVIITNQDAYTATIPGTYPTTIQAGASLMVATRI"
     gene            1495..3120
                     /gene="treC"
                     /locus_tag="AC0DU4_001734"
     CDS             1495..3120
                     /gene="treC"
                     /locus_tag="AC0DU4_001734"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0008788 - alpha,alpha-phosphotrehalase
                     activity [Evidence IEA];
                     GO_process: GO:0005991 - trehalose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HIN4237659.1"
                     /translation="MTLDKGKVVYQIYPKSYKDTTENGIGDFRGIIEKIPYLAKLGVD
                     MVWLNPFYPSPQRDNGYDISDYMAVDPLFGDMADFEEMVCVGKEHKIDFMLDMVLNHC
                     STEHEWFQKALAGDKYYQDFFFIQDQPTDWQSKFGGSAWAPFGDTGKYYLHLFDETQA
                     DLNWRNSNVRKELFKVVNFWRDKGVKGFRFDVINLIGKDEVSVDCPENEGKPAYTDKP
                     IVHNYLRMMNQATFGSDDSFMTVGEMSSTTMENCVLYSSPDRQELSMTFNFHHLKVDY
                     KDGQKWTLAPFDFEELKSLYHSWGKEMSDKDGWSALFWNNHDQPRALNRFVDIQNFRK
                     EGATMLAASIHLSRGTPYIYMGEEIGMIDPDYDSMTDYVDVESLNAYQMLLEEGKSQQ
                     EAFQIIQAKSRDNSRIPMQWDTSENAGFSTGTPWLKVGKSYKDINVENEIKGLIFTFY
                     QDLIRLRKEMPIISEGNYKPAFEDSKQVYAFERQFEDQKLLVLNNFYAKEVEIDLPAV
                     YQNGQILISNYEDAEVSEKILLKPYQTLAIYVN"
     gene            3376..3624
                     /locus_tag="AC0DU4_001735"
     CDS             3376..3624
                     /locus_tag="AC0DU4_001735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000364981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YneF family protein"
                     /protein_id="HIN4237660.1"
                     /translation="MDLLLAIVLIVLAFLGGALGGMYLVRKQIEKEFADNPRLNAEAV
                     RTLLSANGQKPSEAKVQQVYHQIIRQQKAALANNKKKK"
     gene            3831..4625
                     /gene="racE"
                     /locus_tag="AC0DU4_001736"
     CDS             3831..4625
                     /gene="racE"
                     /locus_tag="AC0DU4_001736"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008881 - glutamate racemase activity
                     [Evidence IEA];
                     GO_process: GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HIN4237661.1"
                     /translation="MDNRPIGFLDSGVGGLTVVRELMRQLPHEEIVYIGDSARAPYGP
                     RPAEQIREYTWQLVNFLLTKDVKMIVIACNTATAVVWEEIKAQLDIPVLGVILPGASA
                     AIKSSQGGKIGVIGTPMTVQSDIYRQKIHDLDPDLQVESLACPKFAPLVESGALSTSV
                     TKKVVYETLRPLVGKVDSLILGCTHYPLLRPIIQNVMGPKVQLIDSGAECVRDISVLL
                     NYFEINRGRDAGPLHHRFYTTASSQSFAQIGEEWLEKEIHVEHVEL"
     gene            4622..5593
                     /locus_tag="AC0DU4_001737"
     CDS             4622..5593
                     /locus_tag="AC0DU4_001737"
                     /inference="COORDINATES: protein motif:HMM:NF002698.0"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0047429 - nucleoside triphosphate
                     diphosphatase activity [Evidence IEA];
                     GO_process: GO:0009143 - nucleoside triphosphate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-triphosphate diphosphatase"
                     /protein_id="HIN4237662.1"
                     /translation="MTNKIYEYKDDRDWYVGSYSIFGGVNSLSDYKTDFPLFEFSKIF
                     GDEEYGFPLSVTVLRYGSTYRLFSFVVDMLNQEMGRNLEVIQRHGALLLVENGQLLYV
                     ELPKEGVNVHDFFETSKVRETLLIATRNEGKTKEFRAIFDKLGYDVENLNDYPDLPEV
                     AETGMTFEENARLKAETISQLTGKMVLADDSGLKVDVLGGLPGVWSARFAGVGATDRE
                     NNAKLLHELAMVFELKDRSAQFHTTLVVASPNKESLVVEADWSGYINFEPKGENGFGY
                     DPLFLVGETGESSAELTLEEKNSQSHRALAVKKLLEVFPSWQSKPSL"
     gene            5569..6090
                     /locus_tag="AC0DU4_001738"
     CDS             5569..6090
                     /locus_tag="AC0DU4_001738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001118598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HIN4237663.1"
                     /translation="MAKQTIIVMSDSHGDSLIVEEVRDRYVGKVDAVFHNGDSELRPD
                     SPLWEGIRVVKGNMDFYAGYPERLVTELGSTKIIQTHGHLFDINFNFQKLDYWAQEEE
                     AAICLYGHLHVPSAWMEGKILFLNPGSISQPRGTIRECLYARVEIDDSYFKVDFLTRD
                     HEVYPGLSKEFSR"
     gene            6087..6548
                     /gene="cbpB"
                     /locus_tag="AC0DU4_001739"
     CDS             6087..6548
                     /gene="cbpB"
                     /locus_tag="AC0DU4_001739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000560721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0180001 - cyclic-di-AMP binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cyclic-di-AMP-binding protein CbpB"
                     /protein_id="HIN4237664.1"
                     /translation="MIAKEFETFLLGQEETFLTPAKNLAVLIDTHNADHATLLLSQMT
                     YTRVPVVTDEKQFVGTIGLRDIMAYQMEHDLSQEIMADTDIVHMTKTDVAVVSPDFTI
                     TEVLHKLVDESFLPVVDAEGIFQGIITRKSILKAVNALLHDFSKEYEIRCQ"
     gene            6545..7279
                     /gene="xerD"
                     /locus_tag="AC0DU4_001740"
     CDS             6545..7279
                     /gene="xerD"
                     /locus_tag="AC0DU4_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific tyrosine recombinase XerD"
                     /protein_id="HIN4237665.1"
                     /translation="MRDRISAFLEEKQGLSVNSKQSYKYDLEQFLDMVGERISETSLK
                     IYQAQLANLKISAQKRKISACNQFLYFLYQKGEVDSFYRLELAKQAEKKTEKPEILYL
                     DSFWQESDHPEGRLLALLILEMGLLPSEILAIKVADINLDFQVLRISKASQQRIVTIP
                     TALLSELEPLMGQTYLFERGEKPYSRQWAFRQLESFVKEKGFPSLSAQVLREQFILRQ
                     IENKVDLYEIAKKLGLKTVLTLEKYR"
     gene            7279..8007
                     /locus_tag="AC0DU4_001741"
     CDS             7279..8007
                     /locus_tag="AC0DU4_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000351912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HIN4237666.1"
                     /translation="MDIKLKDFEGPLDLLLHLVSKYQMDIYDVPITEVIEQYLAYVST
                     LQAMRLEVTGEYMVMASQLMLIKSRKLLPKVAEVTDLGDDLEQDLLSQIEEYRKFKLL
                     GEHLEAKHQERAQYYSKAPTELIYEDAELVHDKTTIDLFLAFSNILAKKKEEFAQNHT
                     TILRDEYKIEDMMIIVKESLIGRDQLRLQDLFKEAQNVQEVITLFLATLELIKTQELI
                     LVQEESFGDIYLMEKKEESQVPQS"
     gene            8026..8595
                     /gene="scpB"
                     /locus_tag="AC0DU4_001742"
     CDS             8026..8595
                     /gene="scpB"
                     /locus_tag="AC0DU4_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_process: GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SMC-Scp complex subunit ScpB"
                     /protein_id="HIN4237667.1"
                     /translation="MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQ
                     KYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQ
                     PITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHL
                     EELPVIDELEIQAQESQLFGERIEEDENQ"
     gene            8582..>8996
                     /locus_tag="AC0DU4_001743"
     CDS             8582..>8996
                     /locus_tag="AC0DU4_001743"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_function: GO:0140098 - catalytic activity, acting on
                     RNA [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pseudouridine synthase"
                     /protein_id="HIN4237668.1"
                     /translation="MRINKYIAHAGVASRRKAEELIKQGLVTVNGQVVRELATTIKSG
                     DKVEVEGQPIYNEEKVYYLLNKPRGVISSVTDDKGRKTVVDLLPNVKERIYPVGRLDW
                     DTSGVLILTNDGDFTDEMIHPRNEIDKVYVARVKGV"
BASE COUNT         2533 a         1818 c         2124 g         2521 t
ORIGIN      
        1 gcaaactggg tttggaattt tggctatttt actgttaatc gtatcggtta ccaagcccaa
       61 gttatcccag ccttgcttgc aggtttgagt ctgtcttatc ttgaaatctt ctggcgcaag
      121 catatcccag aagtcatttc tatgattttt gtacctttct tgtcattgat tccagccttg
      181 attttggctc atactgtttt gggaccaatc ggttggacaa ttggacaagg actttcatca
      241 gttgtcttgg caggtttaac tggtccagtt aaatggctct tcggtgcaat ttttggtgcc
      301 ctctacgctc catttgtcat cacaggtctg caccatatga ccaatgccat tgatacacaa
      361 ttgattgcgg atgctggtgg cactgcccta tggccaatga ttgctctttc taatattgct
      421 caaggctcag ccgtgtttgc ctattatttc atgcatcgcc atgatgagcg tgaggctcag
      481 gtttcacttc ctgcaaccat ttcagcctat ctcggtgtta cagaaccagc tctttttggg
      541 gttaacgtaa aatatattta tccatttgtt gctgggatga ctggttcagc ccttgcaggc
      601 atgttatccg ttacttttaa tgtaactgcg gcttctattg gtatcggtgg tttgccaggt
      661 attctctcta ttcaacctca atacatgctg ccatttgcag gaactatgct agttgcgatt
      721 gttgttccaa tgctcttgac tttcttcttc cgcaaggctg gtctctttac aaaaacagag
      781 ggcgatacga acttgcaggc agaattcgtt gctcaagaag aagcagaatt tgtgaaccat
      841 gaaccagtag aacttacttc ggtagaaatt atcagcccac taactggcca agtgaaagaa
      901 ttgagtcaag cgacgaatcc tatttttgca tcaggtgtca tggggcaagg tctggtcatt
      961 gaaccaagcc aaggtgagtt gacctctcca gttaatggga cagtgacggt tcttttccct
     1021 accaagcatg ccatcggcat tgtctctgac gagggagttg aattgctcat ccacatcggt
     1081 atggatacag taggtcttga tggcaaaggt tttgaaagtc ttgtagtcca aggagatcac
     1141 gttacagttg gtcagcaact gattcgtttt gatatggatg tcattaaggc tgcaggtctg
     1201 gtgacagaaa ctcctgttat catcaccaac caagatgctt atacagcgac tattcctgga
     1261 acttatccga caacgatcca agctggagca tctctcatgg tcgctacacg aatctaatac
     1321 tcttcgaaaa tctcttcaaa ccacgtcagc tctatctgca acctcaaaat agtgttttga
     1381 gcaacctgtg gctagcttcc tagtttgttc tttgattttc attgagtata attgaaatag
     1441 cacaaatagg gacggaagac tgcttcctcc cttttatcag aaaaggagaa acagatgaca
     1501 cttgataaag gaaaagtagt ctatcaaatc tatccaaaat cttacaaaga caccactgaa
     1561 aacggtattg gggatttccg tgggattatc gaaaaaattc cctatttagc caaactaggt
     1621 gtggatatgg tctggctcaa tccattctat ccaagccctc aacgggataa tggttacgat
     1681 atttcagatt atatggcagt ggatcctctt tttggtgata tggctgattt tgaggaaatg
     1741 gtgtgtgtcg gtaaagagca caagattgac tttatgctgg acatggtact taatcattgt
     1801 tcgacagagc atgaatggtt tcagaaagcc ctagctggtg ataagtatta tcaagacttt
     1861 ttcttcatcc aagaccaacc aacagattgg cagtctaagt ttggtggttc tgcatgggcg
     1921 cctttcgggg atactgggaa atactatctt cacctatttg atgagaccca ggctgacctt
     1981 aactggcgca attccaatgt ccgtaaggag cttttcaagg ttgttaattt ctggcgcgac
     2041 aagggtgtca aaggtttccg atttgatgtg atcaatttga tcggtaagga cgaggtttca
     2101 gtggactgtc ccgaaaatga agggaagcca gcttatacag acaaacccat cgttcataac
     2161 tatttgcgta tgatgaacca agccactttt ggatctgacg atagctttat gacagttggg
     2221 gaaatgtctt ctaccaccat ggaaaactgt gtcctctatt cgtcgcctga tcgtcaggaa
     2281 ttatccatga cctttaattt tcatcacctc aaggtggact ataaggatgg acaaaagtgg
     2341 accttggctc cctttgattt tgaagagttg aagagtcttt accatagttg gggtaaggaa
     2401 atgagtgata aagacggttg gagtgccctc ttttggaaca atcacgatca accacgtgcc
     2461 ttgaaccgtt ttgtcgatat tcaaaacttc cgcaaggaag gagccaccat gctagcagcc
     2521 agcattcacc tgtcacgtgg gacaccttat atctacatgg gtgaggaaat cgggatgatt
     2581 gacccagact atgattctat gactgattat gtggatgtcg aatcgcttaa tgcctatcag
     2641 atgctcttag aagaaggaaa gagtcagcaa gaagccttcc agattattca agctaagtcg
     2701 cgtgataatt cacgtattcc catgcagtgg gatacttctg aaaatgcagg attttcaaca
     2761 ggcactccat ggttgaaagt tggtaaatcc tataaagata tcaatgtaga aaatgaaatc
     2821 aaaggtctga ttttcacctt ctatcaagac ttgattcgac tgcgtaagga aatgccaatc
     2881 atttcagaag gaaattacaa accagccttt gaagatagca aacaagtcta cgcttttgaa
     2941 cgccagtttg aggatcaaaa gttactagtg ctcaataact tttatgccaa agaagtggaa
     3001 atcgacttgc cagcagtcta ccaaaatgga cagattttga tttcaaacta tgaagatgca
     3061 gaagtgtctg agaaaattct actcaaaccc tatcaaacac tggctattta tgtaaattaa
     3121 tactcttcga aaatctcttc aaaccgtgtc agttttatct gtaacctcaa agcggtgctt
     3181 tgagcaacct gtggctagct tcctagtttg ctctttgatt ttcattgagt ataaacttag
     3241 caaggagacc tctttttcag aaaagcaggg ttctttttgc tgtctattcc atccttgaaa
     3301 gtgtagaaca aactggtcag ggtggctagt ttgtggtata atgaaaggga ctcaaaaaga
     3361 aacaggagaa aaatgatgga tttactttta gcaattgtat tgattgtgct agcttttcta
     3421 ggaggagctc ttggaggaat gtacttggtt cgtaagcaaa tcgaaaaaga atttgctgac
     3481 aacccacgtt tgaatgctga agcagttcgt actcttttga gtgcaaatgg tcaaaaacca
     3541 agcgaagcta aggtacaaca agtttaccac caaatcatcc gccaacaaaa ggcagccctt
     3601 gctaacaata aaaagaaaaa ataaataagg aaaagtctgg gatgaaagtt ccagacttct
     3661 cactatgttg gttatggttt agggatgaga ctttttcctt gcattctatt gatatttgat
     3721 tatgattaag agagaggtag ttgacattct atcaagctgt cggtcagttc gttcagtaca
     3781 aggaatcata atgaacgatc aatcagaaaa aagactagaa agaagactgt atggataatc
     3841 gaccaattgg ttttttggat tcgggtgtcg ggggcttgac cgttgtgcgc gagctcatgc
     3901 gccagcttcc ccatgaagaa atcgtctata ttggagattc ggcgcgggcg ccctatggcc
     3961 cccgtcctgc tgagcaaatt cgtgaatata cttggcagct ggtcaacttt ctcttgacca
     4021 aggatgtcaa aatgattgtc attgcttgta acactgcgac tgcggtcgtc tgggaagaaa
     4081 tcaaggctca actagatatt cctgtcttgg gtgtaatttt gccaggagct tcggcagcca
     4141 tcaagtccag tcaaggtggg aaaataggag tgattggaac gcccatgacg gtacaatcag
     4201 acatataccg tcagaaaatc catgatctgg atcccgactt acaggtggag agcttggcct
     4261 gtcccaagtt tgctcccttg gttgagtcag gtgccctgtc aaccagtgtt accaagaagg
     4321 tggtctatga aaccctgcgt cccttggttg gaaaggtgga tagcctgatt ttgggctgta
     4381 ctcattatcc actccttcgc cctattatcc aaaatgtgat ggggccaaag gttcagctca
     4441 tcgatagtgg ggcagagtgc gtacgggata tctcagtctt actcaattat tttgaaatca
     4501 atcgtggtcg cgatgctgga ccactccatc accgttttta cacaacagcc agtagccaaa
     4561 gttttgcaca aattggtgaa gaatggctgg aaaaagagat tcatgtggag catgtagaat
     4621 tatgacaaat aaaatttatg aatataagga tgaccgggac tggtatgttg ggtcttatag
     4681 tatttttggt ggcgttaaca gtttgagcga ctataagaca gattttcctc tgtttgaatt
     4741 ctccaaaata tttggagatg aagagtatgg tttcccgctt tcagttactg ttttacgcta
     4801 tggttctacc taccgtttgt tctcctttgt ggtagacatg cttaatcaag aaatgggacg
     4861 aaacttggaa gttattcaac gtcatggggc cctgctcttg gttgaaaatg ggcaactctt
     4921 gtatgtagaa ttgcctaaag aaggggtcaa tgttcatgat ttctttgaga caagcaaggt
     4981 cagagaaacc ttgttgattg cgactcgtaa cgaaggtaaa accaaggaat tccgagctat
     5041 ctttgataag ttaggctacg atgtggaaaa tcttaatgac taccctgacc tgcctgaagt
     5101 agcagaaaca ggtatgacct ttgaagaaaa tgcccgcctt aaggcagaaa ccatttctca
     5161 attaacgggc aagatggttt tggcagatga ttctggtctc aaagtcgatg tccttggtgg
     5221 cttaccaggc gtctggtcag ctcgtttcgc aggtgtggga gcaactgacc gtgaaaataa
     5281 tgccaaactc ttgcacgaat tggccatggt ctttgaactc aaggaccgct cggctcagtt
     5341 ccacacaacc ctagtcgtag ccagcccaaa taaggaaagt ttagttgttg aagcagactg
     5401 gtcaggttat attaactttg aacctaaggg tgaaaatggc tttggctatg atcccctctt
     5461 ccttgtagga gagacaggtg agtcatcagc tgaattaacc ctggaagaaa aaaatagtca
     5521 atctcaccgt gccttagccg ttaagaaact tttggaggta tttccatcat ggcaaagcaa
     5581 accatcattg taatgagcga ttcccatggc gatagcttga ttgtggaaga agtccgtgat
     5641 cgctatgtgg gcaaagtcga tgccgttttt cataacggcg attctgaact acgtccggat
     5701 tctccacttt gggagggcat ccgcgttgtt aaagggaaca tggacttcta cgccggctac
     5761 ccagaacgtc tggtgactga gcttggttcg accaagatta tccaaactca tggtcacttg
     5821 tttgacatca atttcaactt tcaaaagttg gactactggg ctcaggagga agaggccgct
     5881 atctgcctct atggtcactt gcatgtgcca agtgcttgga tggaaggcaa gatcctcttt
     5941 ctaaatccag gttctatcag ccaaccacga ggtaccatca gagaatgtct ctatgctcgt
     6001 gtggagattg atgatagtta cttcaaagtg gactttttga cacgagatca cgaggtgtat
     6061 ccaggtttgt ccaaggagtt tagccgatga ttgccaagga gtttgagact ttcttgttgg
     6121 ggcaggagga aacttttttg acccctgcta aaaatctagc tgtgttgatt gatacccaca
     6181 atgcggatca tgcgaccctc ttgctcagtc agatgaccta tacccgtgtt cccgttgtga
     6241 cagatgaaaa acagtttgtt gggacgattg gactcagaga tattatggcc tatcagatgg
     6301 agcatgactt gagccaagaa atcatggcgg atacggatat cgttcatatg acaaaaacgg
     6361 acgtagcggt tgtttcgcct gatttcacca ttacggaggt cttgcacaag ctagtagatg
     6421 agtccttctt accggttgtg gatgcagagg gtattttcca agggattatt acgcgcaagt
     6481 ccatcctcaa ggccgttaat gccctcttgc atgactttag taaggaatat gagattcgat
     6541 gccaatgaga gacaggattt cagccttttt agaggaaaag cagggcttgt ctgtcaattc
     6601 caagcagtcc tataagtatg atttggagca atttttagac atggtaggtg agcggatttc
     6661 tgagaccagt ctcaagattt accaagccca gctagccaat ctaaaaatca gcgcccagaa
     6721 gcgaaagatt tcggcctgta accaatttct atactttctc tatcaaaaag gagaggtgga
     6781 cagcttttac cgcttggaat tagccaaaca agctgaaaag aagacggaaa agccagagat
     6841 tctataccta gactcttttt ggcaggaaag cgaccatcca gagggccgct tgctagcgct
     6901 cttaatccta gaaatggggc ttttgcccag tgagatttta gccatcaagg ttgcggacat
     6961 caatctggat tttcaggtgt tgcgaatcag caaggcttcc caacagagga ttgtcaccat
     7021 tcccacggcc ttgctttcag aattggaacc cttgatgggg cagacctatc tttttgaaag
     7081 aggagagaaa ccctattctc gtcagtgggc ctttcgtcag ttagaatctt ttgtcaagga
     7141 gaaaggtttt ccatccttat cagctcaagt cttacgtgaa cagtttattc taagacaaat
     7201 agaaaacaag gtcgatttgt acgaaattgc aaaaaaatta ggattaaaaa cagtcctgac
     7261 cttagaaaaa tatagataat ggatattaaa ttaaaagatt ttgaaggacc cctggacttg
     7321 ctcttgcatc tggtttctaa gtaccagatg gatatctacg atgtgcccat tacggaagtc
     7381 atcgaacagt atctagccta tgtctcaacc ctgcaggcca tgcgtctgga agtgacgggt
     7441 gagtacatgg tcatggctag tcagctcatg ctgattaaga gtcgtaaact ccttccgaag
     7501 gtagcagaag tgacagactt gggggatgac ctggagcagg acctcctctc tcaaatcgaa
     7561 gaatatcgca agttcaagct cttgggtgag cacttggaag ccaagcacca agaacgggcc
     7621 cagtattatt ccaaagcgcc gacagagttg atttacgaag atgcggagct tgtgcatgac
     7681 aagacgacca ttgacctctt tttggctttt tcaaatatcc tagccaagaa aaaagaggag
     7741 tttgcacaaa atcacacgac gatcttgcgg gatgagtata agattgagga catgatgatt
     7801 atcgtgaaag agtccttgat tggacgagat caattgcgct tgcaggattt gttcaaggaa
     7861 gcccagaatg tccaagaggt catcaccctc tttttggcaa ccctagagtt aatcaaaacc
     7921 caggagctga tcctcgtgca agaggagagt ttcggagata tctatctcat ggaaaagaag
     7981 gaagaaagtc aagtgcctca aagctagact tgatagagag gaaagatgag tactttagca
     8041 aaaatagaag cgctcttgtt tgtagcgggt gaagatggga ttcgggtccg ccagttagct
     8101 gaactcctct ctctgccacc gacaggcatc cagcaaagtt taggaaaatt agcccagaag
     8161 tatgaaaagg acccagattc cagtttggct ttgattgaga caagtggtgc ttatagattg
     8221 gtgaccaagc ctcaatttgc agagattttg aaggaatact ctaaggcgcc tatcaaccag
     8281 agcttgtctc gggctgccct tgagaccttg tccattattg cctacaaaca gccgattacg
     8341 cggatagaaa ttgatgccat ccgtggagtt aactcgagtg gagccttggc aaagttgcag
     8401 gcttttgacc tgataaagga agacgggaaa aaggaagtat tggggcgccc caacctctat
     8461 gtgactacgg attatttcct agattacatg gggataaacc atttagaaga attaccagtg
     8521 attgatgagc ttgagattca agcccaagaa agccaattat ttggtgaaag gatagaagaa
     8581 gatgagaatc aataagtata ttgcccacgc aggtgtggcc agtaggagaa aagcagaaga
     8641 gctgattaag caaggcttgg tgacggttaa cggccaagtg gtgcgtgaac tagcaaccac
     8701 tatcaagtca ggcgacaagg tcgaagttga aggtcaacct atctacaacg aagaaaaggt
     8761 ctactatctg cttaacaaac cacgcggtgt gatttccagt gtgacagatg ataagggtcg
     8821 caagacggtt gtcgacctct tgcccaatgt caaagagcgt atttaccctg tgggtcgttt
     8881 ggactgggat acatcaggtg tcttgatttt gaccaatgat ggggacttta cagacgagat
     8941 gattcaccct cgtaatgaga ttgacaaggt ttatgtcgcg cgtgttaaag gtgtgg
//
LOCUS       DBMVGT010000067         8547 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.067, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000067 DBMVGT010000000
VERSION     DBMVGT010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 8547)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8547)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8547
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.067"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(2..1615)
                     /locus_tag="AC0DU4_001744"
     CDS             complement(2..1615)
                     /locus_tag="AC0DU4_001744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HIN4237669.1"
                     /translation="MEIMSLAIAVFAVIIGLVIGYVSISAKMKSSQEAAELMLLNAEQ
                     EATNLRGQAEREADLLVNEAKRESKSLKKEALLEAKEEARKYREEVDAEFKSERQELK
                     QIESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAE
                     LERIGALSQAEARDIILAQTEENLTREIASRIREAEQEVKERSDKMAKDILVQAMQRI
                     AGEYVAESTNSTVHLPDDTMKGRIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFD
                     PIRREIARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEAAAYEIGAPNLHP
                     DLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAID
                     HEVEGSHVEIGMELARKYKEPPVVVNTIASHHGDVEAESVIAVIVAAADALSAARPGA
                     RSESLESYIKRLHDLEEIANGFEGVQTSFALQAGREIRIMVNPGKIKDDKVTILAHKV
                     RKKIENNLDYPGNIKVTVIRELRAVDYAK"
     gene            complement(1884..2114)
                     /locus_tag="AC0DU4_001745"
     CDS             complement(1884..2114)
                     /locus_tag="AC0DU4_001745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0097351 - toxin sequestering activity
                     [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0045927 - positive regulation of growth
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="HIN4237670.1"
                     /translation="MEGVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKS
                     EWDSIQETLRIAQNKELSDKVLRGMDKIRAGH"
     gene            complement(2352..3449)
                     /locus_tag="AC0DU4_001746"
     CDS             complement(2352..3449)
                     /locus_tag="AC0DU4_001746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000156376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HIN4237671.1"
                     /translation="MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAI
                     VDKWTRAQMALENGADLVVELPFLVSVQAADFFGQGAVDILDRLGIDSLVFGTEEVRD
                     YQKIADLYTEKGAEMEKFVENLPDSLSYPQKTQSMWKEFAGLDFSGNTPNHVLALAYA
                     KAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQA
                     SKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVELVTTKRY
                     TKARVRRLLTYILVQARENVLPEAIHVLGFTEKGRQHLKSLKGQVNLVSRIGKEPWDA
                     MTQKADQIYQLGKPSIAEQNFGRVPIRIETN"
     gene            complement(3459..4199)
                     /locus_tag="AC0DU4_001747"
     CDS             complement(3459..4199)
                     /locus_tag="AC0DU4_001747"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent DNA methyltransferase"
                     /protein_id="HIN4237672.1"
                     /translation="MATYETFAAVYDAVMDDSLYDKWTNFSLRHLPKTKEKKKLLELA
                     CGTGIQSVRFSQAGFDVTGLDLSADMLKIAEKRATSAKQKIAFIEGNMLNLSKAGKYD
                     FVTCYSDSICYMQDEVEVGDVFKDVYNALNEEGVFIFDVHSTYQTDEVFPGYSYHENA
                     EDFAMLWDTYEDEAPHSIVHELTFFIKEADGSFSRHDEVHEERTYEILTYDILLEQAG
                     FKSFKLYADFEDKEPTETSTRWFFVAQK"
     gene            complement(4308..4661)
                     /gene="rsfS"
                     /locus_tag="AC0DU4_001748"
     CDS             complement(4308..4661)
                     /gene="rsfS"
                     /locus_tag="AC0DU4_001748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0017148 - negative regulation of
                     translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HIN4237673.1"
                     /translation="MNEKELLELVVKAADEKRAEDILALDVQDLTSVTDYFVITSSMN
                     SRQLDAIAANIREKVAQAGFKGSHVEGDAAGGWVLLDLGAVVVHIFSEEMRAHYNLEK
                     LWHEANSVDISEALA"
     gene            complement(4674..5174)
                     /locus_tag="AC0DU4_001749"
     CDS             complement(4674..5174)
                     /locus_tag="AC0DU4_001749"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase family protein"
                     /protein_id="HIN4237674.1"
                     /translation="MKTAFIIIDVQNVLVETGFQTKSLLGKISYLQNQARSKNIEIIY
                     VQHIENSEAQTSEDWQLSALLNRKPAEKVFQKKYNSIFKETGLKEYLDKQGIEKLVLC
                     GMQTEYCVDTSVKVAFEYGYQLIVPEGAVTTFDGDDIPAETINEFYEDIWEERFADVL
                     DYKHIF"
     gene            complement(5175..5768)
                     /gene="yqeK"
                     /locus_tag="AC0DU4_001750"
     CDS             complement(5175..5768)
                     /gene="yqeK"
                     /locus_tag="AC0DU4_001750"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HIN4237675.1"
                     /translation="MSYQDYINCSREALLEKMAELLPEKRLTHCLGVERAAMELAQRF
                     GVDVEKASLAGLLHDYAKKLSDQEFLALIDRYQLDPDLKNWGNNVWHGMVGIYKIQED
                     LDLHDSEILRAIEVHTVGAGQMTDLDKVIYVADYIEHNRAFPGVDVAREIASLSLNKA
                     VAYETARTVEYLAHQGFPIYPQTLETYNAFVHYLKEN"
     gene            complement(5768..6397)
                     /locus_tag="AC0DU4_001751"
     CDS             complement(5768..6397)
                     /locus_tag="AC0DU4_001751"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HIN4237676.1"
                     /translation="MTIELLTPFTKVELEPEIKEKKRKQVGILGGNFNPVHNAHLIVA
                     DQVRQQLGLDQVLLMPEYQPPHVDKKETIPEHHRLKMLELAIEGIDGLVIETIELERK
                     GISYTYDTMKILTEKNPDTDYYFIIGADMVAYLPKWYRIDELVDMVQFVGVQRPRYKV
                     GTSYPVIWVDVPLMDISSSMVRDFLAQGRKPNFLLPQPVLDYIEKEGLY"
     gene            complement(6449..6760)
                     /gene="yhbY"
                     /locus_tag="AC0DU4_001752"
     CDS             complement(6449..6760)
                     /gene="yhbY"
                     /locus_tag="AC0DU4_001752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome assembly RNA-binding protein YhbY"
                     /protein_id="HIN4237677.1"
                     /translation="MSLTSKQRAFLNSQAHTLKPIIQIGKNGLNDQIKTSVRQALDAR
                     ELIKVTLLQNTDENIHEVAEILEEEIGVDTVQKIGRILILFKQSSKKENRKISKKVKE
                     I"
     gene            complement(6974..8080)
                     /gene="yqeH"
                     /locus_tag="AC0DU4_001753"
     CDS             complement(6974..8080)
                     /gene="yqeH"
                     /locus_tag="AC0DU4_001753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391231.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YqeH"
                     /protein_id="HIN4237678.1"
                     /translation="MEEILCIGCGATIQTTDKAGLGFTPQSALEKGLETGEVYCQRCF
                     RLRHYNEITDVQLTNDDFLKLLHEVGDSDALVVNVIDIFDFNGSVIPGLPRFVSGNDV
                     LLVGNKKDILPKSVKSGKISQWLMKRAHEEGLRPVDVVLTSAQNKHAIKEVIDKIEHY
                     RKGRDVYVVGVTNVGKSTLINAIIQEITGDQNVITTSRFPGTTLDKIEIPLDDGSYIY
                     DTPGIIHRHQMAHYLTAKNLKYVSPKKEIKPKTYQLNPEQTLFLGGLGRFDFIAGEKQ
                     GFTAFFDNELKLHRSKLEGASAFYDKHLGTLLTPPNSKEKEDFPSLVQHVFTIKDKTD
                     LVISGLGWIRVTGIAKVAVWAPEGVAVVTRKAII"
     gene            complement(8083..>8547)
                     /locus_tag="AC0DU4_001754"
     CDS             complement(8083..>8547)
                     /locus_tag="AC0DU4_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008962 - phosphatidylglycerophosphatase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="HIN4237679.1"
                     /translation="SLQAQGIKAVLVDLDNTLIAWNNPDGTPEMKQWLHDLRDAGIGI
                     IVVSNNTKKRVQRAVEKFGIDYVYWALKPFTFGIDRAMKEFHYDKKEVVMVGDQLMTD
                     IRAAHRAGIRSILVKPLVQHDSIKTQINRTRERRVMRKITEKYGPITYKKGI"
BASE COUNT         2252 a         2003 c         1675 g         2617 t
ORIGIN      
        1 tttatttagc ataatctact gcacgaagct cgcgaatcac ggttaccttg atatttcctg
       61 gataatcgag attgttttca attttcttac gaactttgtg agccaagatt gtgactttgt
      121 cgtccttgat ttttcctgga ttgaccatga tacgaatttc acgtcctgct tgaagggcaa
      181 agctagtttg cactccttca aagccgttag caatttcttc caaatcatgg agacgcttga
      241 tgtagctttc aagagactca ctacgagcac ctggacgggc tgcgctcaag gcatctgctg
      301 cagcgacgat aactgctatc acgctctcag cttcaacatc tccgtggtga ctagcaatcg
      361 tattcaccac aactgggggt tccttgtact tacgggccaa ttccataccg atttcaacgt
      421 ggctaccttc aacctcatgg tcaatggctt tcccgatatc gtgaaggaat ccagcacgac
      481 gggcaagagc cgcattttca ccaagttcgc tcgccatgat accagccaac ttagcaacct
      541 caatcgaatg gcgcaaaaca ttttgtccat atgaagtacg gaactgcaaa cgtcccataa
      601 tcttcatcaa gtctggatga aggtttggcg caccaatttc ataggcagca gcctcaccgt
      661 attcacgaat cttattgtca atctcttgac ggtttttctc aaccaactct tcgatacgag
      721 ctggatgtat acgaccatct ttgagcaaca tttccatagt catacgggca atctcacgac
      781 gaatcggatc aaatcctgac aaggtcacca cttctggtgt atcgtcgata atcacatcga
      841 cccctgtcaa actttcaaag gtacgaatgt tacgaccttc acgaccaata atgcgtccct
      901 tcatagtatc gtctggcaga tgaactgttg agtttgttga ctccgctaca tattcaccag
      961 cgatacgttg catagcttga accaagatgt ccttggccat tttgtcagaa cgttccttga
     1021 cctcttgctc agcttcgcga atgcgactgg caatctccct ggtcaagttt tcctctgtct
     1081 gagccaagat aatatctcgt gcttctgcct gagacagagc accaatacgc tctagttctg
     1141 cttctttttg tctttcgact tcctctaatt gctcttcacg cgcatcaagg tttttcgctc
     1201 tatcagaaat actttgttct ttttgttcaa gtgtttgttc tttactcgtc aaattgtcgt
     1261 ccttacggtc aaggctagta gctctctctg tcaaacgact ttcgatttgt ttgagttctt
     1321 gacgttctga tttgaattca gcgtccactt cttcacggta ttttctggct tcttctttgg
     1381 cctccaatag tgcttctttt ttaagagact tgctttcacg tttggcttca ttaacaagta
     1441 aatccgcttc acgctcagct tgtccacgta aattagttgc ttcttgttca gcatttaaaa
     1501 gcatcaactc tgcagcttcc tgagatgatt tcatcttagc tgagatgctg acatatccaa
     1561 tgactaaacc aatgatgacg gcaaaaacag caatcgcaag cgacatgatt tccatgtttt
     1621 tacctcattt tattgttatt ccgaatgaca tacattcttt tacattctac cataaaaaag
     1681 tgattttcac aaacctaaaa tagaatatgt tttggggaat ttggaacaca tttaccaaaa
     1741 taaacttgtt gtttagaaat agtagtttag tagagacttg agaaaaagcc tactttgcag
     1801 tagacttcct aatgattatg caatacaaga agtttgtttc taacaacagc aagatttcac
     1861 tcaggtattc tctgtaaatt agactagtgt cctgcgcgaa ttttatccat tcctcgcaaa
     1921 accttgtctg ataactcctt attttgggcg attctcaggg tttcctgaat actgtcccat
     1981 tcgctctttg aaagaactac aatgtcctca tctggatttt tattgaccac cgtcaaaggc
     2041 tcaaattcat catttacctt cttcatgtaa tcctttaaat gatttcggaa tgttgagtaa
     2101 agaactcctt ccataaccat acctcgtttt agctcttttc cactattata cacgaaaaga
     2161 aagaaattgt caggaacctg tacaagattt tcttttctat ctatttatac tcaatgaaaa
     2221 tcaaagagca aactaggaaa ctagcctcag gctgtacttg agtacggcaa agcgacgttg
     2281 acgcgatttg aatttgattt tcgaagagta ttattcgtaa aaaatctcaa aaagcctacc
     2341 ttttagtaga cttagtttgt ttctattcta atcggcactc ttccaaaatt ttgctctgct
     2401 atacttggct ttcctagttg gtaaatctgg tctgcttttt gggtcatagc atcccaaggt
     2461 tctttgccaa ttcggctgac tagattgacc tgtcctttca gagacttgag atgttgcctg
     2521 cctttttcag taaatccaag gacatgaatg gcttctggca agacattttc cctagcctgc
     2581 accaaaatat aggtcaatag gcgtctgaca cgcgccttgg tgtaacgttt ggtagtcact
     2641 aactcgacca attcttccac agactgggct gttttaatag cttctttaat gcgcacagcc
     2701 atttcttgat tgacctgata gatggtggtt aggtcgggat ttgacaagat ttgatagcgg
     2761 agcaagggaa aatagtcttc ccagatcacc ttactggcct gctcaaatag ggcaacagaa
     2821 ggcataaaac gttctaagaa atcttggtcc ttctgatgtt gacggagggc tgtcgccgag
     2881 gcaaagtcca catctttatt cacagaatgg taacctgccc cctgacgctg aatcggatgc
     2941 agcttgatat ttcgtcctgc aaccgccttt gcataggcca gagcaagaac atgattgggg
     3001 gtattacctg aaaaatcaag accagcaaat tccttccaca tagattgggt tttctgggga
     3061 taggaaaggg aatcaggcag attttccaca aatttctcca tctcagcacc tttctctgtg
     3121 tataagtcag cgattttctg ataatctcga acttcctctg tcccaaaaac tagactatca
     3181 atgcccaagc gatccaagat atccacagct ccttgaccaa agaaatcagc tgcctgaaca
     3241 ctgactaaaa agggcaattc cactaccaag tctgcgccat tttccagcgc catctgggcc
     3301 cttgtccact tatccacaat agcaggctct ccacgctgca tgaaattccc tgacatggca
     3361 acaattttca gtccctctgc ctgatccagc aggtatttat ggccattatg aaaaggattg
     3421 aactccgcga taatacctgt gatggtcatg ctaatctcct acttctgcgc cacaaaaaac
     3481 caacgggtgc tagtttctgt tggttcctta tcctcaaagt ctgcatagag tttgaaggac
     3541 ttgaatccag cctgttccag taagatatca taggtcaaga tctcataggt cctctcctca
     3601 tgtacttcat cgtggcgact aaaggaaccg tcagcctcct tgataaagaa agtcagctca
     3661 tgcacgatgg agtgaggagc ttcgtcctca tatgtatccc aaagcatggc aaaatcttcc
     3721 gcattttcat ggtaggaata gccagggaat acttcatctg tctggtaggt cgagtgcacg
     3781 tcaaagatga aaactccctc ttcattcagc gcattgtaca cgtccttaaa gacgtcccct
     3841 acttccacct catcctgcat atagcagata gagtccgaat aacacgtgac aaaatcgtat
     3901 ttccctgcct tggacaaatt cagcatatta ccttctataa aagcaatctt ttgcttggct
     3961 gaagttgctc tcttctccgc aatcttcaac atatccgcac tcaagtcaag tccagtcaca
     4021 tcaaaaccag cctgagagaa gcgcactgat tgaattcctg tcccacaagc cagttccaag
     4081 agtttctttt tctccttggt cttaggcaaa tgacgcagag aaaaatttgt ccatttgtcg
     4141 tataaactat cgtccatgac cgcatcatag accgccgcaa aggtttcata agtcgccata
     4201 atcatgatac taagagctcc atggtaaaca ccactagccc tttacctttc tatcaatttt
     4261 tctaaaataa gcaaagaaac ccagttgact acaactgagt tcatcttcta agcaagagct
     4321 tctgaaatat ctactgaatt cgcctcatgc catagcttct ctagattata atgggcacgc
     4381 atttcttctg aaaagatatg cacgacaaca gcaccgaggt ccagtaagac ccagcctcca
     4441 gctgcatcgc cttcgacatg gctaccttta aagcccgctt gagctacttt ttcacggata
     4501 ttagctgcga tagcgtccaa ctgacggcta ttcattgagc tagtgatgac aaagtagtcc
     4561 gtcacactag tcaaatcttg tacatcaagt gcgaggatat cctccgcacg tttctcatca
     4621 gccgctttca cgactagttc tagtaattct ttttcgttca tttaatcctc tttttagaaa
     4681 atatgtttgt aatctaggac atctgcaaag cgctcctccc aaatgtcctc ataaaattca
     4741 ttaatcgttt ctgctggaat gtcatcccca tcaaaggttg tgacagcacc ttctggaaca
     4801 ataagctgat agccatattc aaaggcaacc ttgacagagg tatccacaca atattctgtc
     4861 tgcataccac ataaaactaa tttttcaatc ccctgcttat ccaagtattc ttttaagcca
     4921 gtttctttga aaatactgtt atacttcttc tgaaagacct tttcagcagg ttttcgattt
     4981 aaaagcgcag ataactgcca atcttctgat gtttgagctt cagagttctc aatatgttga
     5041 acatagataa tttcaatatt cttgcttcta gcctggtttt gtaaataaga aatttttccc
     5101 aatagacttt ttgtctggaa cccagtttct actaaaacat tctgaacatc aatgattata
     5161 aaagccgtct tcatttagtt ctctttcaaa tagtgcacaa aggcgttata ggtttcaagg
     5221 gtttggggat atatggggaa tccctgatga gctagatact ccacggtacg agctgtttcg
     5281 taggccaccg ccttattgag cgatagactt gcaatctcac gcgccacatc tactccagga
     5341 aaggctcgat tgtgctcgat atagtctgcg acgtagatga ccttatctag gtctgtcatt
     5401 tgaccagcac cgactgtatg gacttcaatg gctcgcagga tttctgaatc atgcaaatcc
     5461 aaatcttcct gaattttgta aattccgacc ataccatgcc agacattatt gccccagttt
     5521 ttgaggtcag ggtctagctg gtaacggtca atcaaggcta gaaattcctg atctgacaac
     5581 tttttagcat agtcatgaag aagacctgct agacttgctt tctcaacatc tacaccaaag
     5641 cgctgagcta attccatagc ggcacgctcc acacctagac aatgggttag acgtttctca
     5701 ggtagaagct ctgccatttt ttccaacaag gcctcacggg agcagttgat atagtcttga
     5761 taggacatca gtagagcccc tccttctcga tgtagtctag cactggctga ggtaggagaa
     5821 agttgggttt ccgaccttgg gcaaggaagt cccgcaccat gctggacgag atatccatga
     5881 gcggtacgtc cacccagata actggatagg aagtccctac cttgtagcgt ggacgctgaa
     5941 cccccacaaa ctgaaccatg tcaaccagtt catcaattcg gtaccactta ggcagatagg
     6001 caaccatgtc ggcaccgatg ataaagtaat aatccgtatc tggattcttc tctgtcaaaa
     6061 tcttcatggt atcgtaggtg taggaaatac ccttgcgctc caactcaatg gtttcaatga
     6121 ctaggccgtc aatcccctca attgccaact caagcatctt gagacgatgg tgttcaggga
     6181 tggtttcctt tttatcaacg tgaggaggtt ggtattcagg catgagaaga acttgatcca
     6241 gtcccaactg ttgccgtact tgatccgcaa caatgagatg ggcattgtga acagggttaa
     6301 aattcccccc taaaatccca acttgtttgc gttttttctc cttgatttct ggctccaact
     6361 ctaccttggt aaagggagtc aatagttcga ttgtcatagg ctagtcccct ttatttctct
     6421 ataaaaacag ttatttggag tttcggtctt agatttcttt gactttctta gaaatcttgc
     6481 gattttcttt cttgctagat tgtttaaaca aaatcaagat gcgtcctatt ttttggactg
     6541 tatccacacc gatttcttct tccaaaattt cagctacttc gtggatgttt tcatctgtgt
     6601 tttgtaagag agtaaccttg attaattcac gcgcatcaag agcttgacgg acgctggttt
     6661 tgatttggtc gttgagtcca tttttcccga tttggatgat aggtttgagg gtgtgtgcct
     6721 ggctgttgag gaaggcacgt tgttttgatg ttaatgacat aattttcttc cttgtttttg
     6781 gatagttatt ttaggtggtg agggacggtc ggaactaatt ttccaaagat ttcatctttg
     6841 aaaaatggat ttcctgacct cacaattgag ccttggtctc aattgtgccc cttgccaatc
     6901 tacagattgg caatcacacc acggcaataa ctatcgctat atgagctcac tttgttcgct
     6961 cagcgatttt gttttaaata attgcttttc gtgtgacgac ggcgacgcct tctggtgccc
     7021 agacggcgac ttttgctatg cctgttacac gaatccagcc taggcctgag atgactaggt
     7081 ctgtcttatc tttaatggta aagacatgct ggactagact tgggaaatct tctttttcct
     7141 tgctatttgg tggtgtcaga agagttccca ggtgcttatc gtagaaagca ctagctcctt
     7201 caagcttgct acgatggagt ttgagttcat tatcaaagaa agcagtaaat ccttgctttt
     7261 ctcctgctat aaagtcaaag cgtcccaaac cacctaaaaa tagggtttgc tcaggattaa
     7321 gctgataggt cttaggcttg atttcctttt taggactgac atacttgagg tttttggccg
     7381 tcaagtagtg agccatctgg tggcggtgga taattcccgg cgtatcgtaa atataagatc
     7441 cgtcgtcaag cggaatctct attttgtcca aggttgtccc tgggaagcgt gaagtagtga
     7501 tgacattctg atcacccgtg atttcttgga taatagcatt gattagagtt gattttccaa
     7561 cgttggtcac accgaccaca tagacatcgc ggcccttacg gtagtgttca atcttgtcaa
     7621 tgacttcctt aatggcatgt ttattttgtg ctgaagttag gaccacatcg actggacgaa
     7681 gaccttcttc atgggcacgt ttcatgagcc actggctaat cttaccagac ttaactgact
     7741 taggaaggat atctttttta tttcctacca agaggacatc attgcccgag acgaaacgtg
     7801 gtaaacctgg gatgacagat ccattaaaat caaagatatc aataacattg accactaaag
     7861 catcactgtc tcccacctcg tgcaagagct tgaggaaatc atcgttcgtc aactggacat
     7921 ctgtgatttc attgtagtgg cggagacgga aacagcgttg gcaatagact tcgccagtct
     7981 ccaaaccttt ttcaagtgcc gactgggggg taaaaccaag accagcttta tctgtcgtct
     8041 gaatggttgc tccacaacca atacagagaa tttcttccat agttaaattc cttttttata
     8101 tgtaatcggt ccgtactttt cagtgatttt tctcataaca cgacgctcac gagttcggtt
     8161 aatctgcgtt ttgattgagt catgttggac caagggtttg actaaaattg accgaatccc
     8221 tgcacggtgg gctgctcgta tatctgtcat gagctggtca ccaaccatga ccacttcctt
     8281 tttgtcatag tggaattcct tcatagcacg gtcaatacca aatgtgaagg gcttcaaggc
     8341 ccaataaacg taatcaatcc caaatttctc aactgctcgt tgaacgcgtt ttttggtgtt
     8401 atttgacact acgataatgc caatacccgc gtcccgaagg tcatgtagcc attgcttcat
     8461 ctctggcgtt ccatcagggt tgttccaagc aatgagggta ttatccaaat cgaccaaaac
     8521 agccttgatt ccctgcgcct gcaggct
//
LOCUS       DBMVGT010000068         8224 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.068, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000068 DBMVGT010000000
VERSION     DBMVGT010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 8224)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8224)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8224
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.068"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1244)
                     /locus_tag="AC0DU4_001755"
     CDS             complement(<1..1244)
                     /locus_tag="AC0DU4_001755"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0016836 - hydro-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HIN4237680.1"
                     /translation="MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVIS
                     TWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDI
                     IADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKD
                     IDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLP
                     GSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNA
                     TLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLL
                     ANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDG
                     AVAKVSGVKVRRHVGPAKVFDS"
     gene            complement(1477..2409)
                     /locus_tag="AC0DU4_001756"
     CDS             complement(1477..2409)
                     /locus_tag="AC0DU4_001756"
                     /EC_number="2.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HIN4237681.1"
                     /translation="MMRSTKELRHVYRDFLLEANQSYSDIVVLEADLSSSMATNNLEK
                     NFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFGPFASRRVFDQLFISLGYAQLDA
                     TVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLK
                     YIRTIRKAPEAVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSV
                     GVIDLFRIKPIPEQIKTMLSGKTIFTVENHNQIGGIGSALCELFSDDGITKIHRMGVQ
                     ERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR"
     gene            complement(2406..3263)
                     /locus_tag="AC0DU4_001757"
     CDS             complement(2406..3263)
                     /locus_tag="AC0DU4_001757"
                     /EC_number="2.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HIN4237682.1"
                     /translation="MILSKNREDGLRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVL
                     AVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNTNGTK
                     LPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCW
                     EAIQFASHQQLSNLIVFVDDNKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIR
                     EIYEGIVQLKQSNNSSPKCIVLDTIKGQGVQELEEMKSNHHLRPTVEEKQMLTSVVER
                     LSQELEETE"
     gene            complement(3267..4613)
                     /locus_tag="AC0DU4_001758"
     CDS             complement(3267..4613)
                     /locus_tag="AC0DU4_001758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000975284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HIN4237683.1"
                     /translation="MMKFILDIVSTPAILVALIAILGLVLQKKKLPDIIKGGIKTFVG
                     FLVVSGGAGIVQNSLNPFGTMFEHAFHLSGVVPNNEAIVAVALTTYGSATAMIMFAGM
                     VFNILIARFTRFKYIFLTGHHTLYMACMIAVILSVAGFTSLPLILLGGLALGIIMSIS
                     PAFVQKYMVQLTGNDKVALGHFSSLGYWLSGFTGSLIGDKSKSTEDIKFPKSLAFLRD
                     STVSITLSMAVIYIIVAIFAGSEYIEKEISSGTSGLVYALQLAGQFAAGVFVILAGVR
                     LILGEIVPAFKGISERLVPNSKPALDCPIVYTYAPNAVLIGFISSFVGGLVSMAIMIA
                     SGTVVILPGVVPHFFCGATAGVIGNASGGVRGATIGAFLQGILISFLPVFLMPVLGGL
                     GFQGSTFSDADFGLSGIILGMLNQFGSQAGIVIGLVLILAVMFGVSFIKKPSAKEE"
     gene            complement(4626..4910)
                     /locus_tag="AC0DU4_001759"
     CDS             complement(4626..4910)
                     /locus_tag="AC0DU4_001759"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008089859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4237684.1"
                     /translation="MLKIGTACGSGLGSSFMVQMNIESVLSDLNVSDVEVEHYDLGGA
                     DPNAADIWIVGRDLADSASHLGDVRILNSIIDMDELRELITKLCEEKGLI"
     gene            complement(4914..6944)
                     /locus_tag="AC0DU4_001760"
     CDS             complement(4914..6944)
                     /locus_tag="AC0DU4_001760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000460919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HIN4237685.1"
                     /translation="MFDYRALVILMTLMDHCELSLYELSVKVSLPIKEVKEGIDYLVP
                     YLANKGIVLDKKQGRYSLSNRTKQSLTDIIKSDELVLPKSTRLALIYLYTFCRLDFIS
                     NNHYQDFLKVSKNTTLSDIQSLRKIMLDNDLELGYSRAKGYTLHGSEWNKHRLAFQMV
                     SELLESSIGIWGLDYVLSSWGYSLTYDLINQVVKDYYEKLQLVPIVNQLKVCLFGLVF
                     ILCRYQRDVERVCLSETLVSPVIQDITTILLDTVVDLGIIDTVFSEDDYRYITVLLSS
                     CFEGEVDVAPVYFNQLTEAIISRMEDISLLHFKQREGLRENLRRHLIPAYYRLKFGLP
                     SSNEYVLHVKEHYPDLFELVKDSLMPLMDAIDNPIPDSETAYFVIHFGGYLKKADTLP
                     QKCYKAAIICPNGVSSSLMLKENLLALFPQIEFIGTSKIDDLQVKASSDYDMVFSTIK
                     VETEKPNYLVSVMMTEEQAIQLVELVLKDFPNLEYGDFEIEQILNIVKRYGIITQELE
                     LRLALKNYLYQKNDRKEIVPVLEQLITKETYQVSSQKLGWKEAIRLAAKPLLDQDKIT
                     ENYPEAMIQKVEEFGPFINLGKGVAIPHARPDEGVNEIGMSMLVLEEPIYLLDNPEQE
                     VRLLICIAAIDNESHLKALSHLTTILRDKNHVQTLISSKNYDDIKMIIKQED"
     gene            7135..8142
                     /locus_tag="AC0DU4_001761"
     CDS             7135..8142
                     /locus_tag="AC0DU4_001761"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HIN4237686.1"
                     /translation="MTEKLINSKPNGVFALILIELTIVLGVFIFIMGVGSENIFGIII
                     GPLLIVIAGLAHAGLKVVKPQEALVLTLFGNYTGTIKEPGFYFVNPFSVAVNPANHTR
                     LGQSGDVSTKSPFLGAKSSNDNDVNLEIGKKHISLKVMTLSNSRQKINDCLGNPVEIG
                     IAVTWRVVDTAKAVFNVDNYKEYLSLQCDSALRNIVRIYPYDVSPNVDTTGDGQADEG
                     SLRGSSEIVANRIREEIQSRVEDAGLEILEARITYLAYAPEIAAVMLQRQQASAIIDA
                     RKMIVDGAVGMVEMALERLNEGELVELDEERKAAMVSNLLVVLCGNHDAQPIVNTGSL
                     Y"
     gene            8145..>8224
                     /locus_tag="AC0DU4_001762"
     CDS             8145..>8224
                     /locus_tag="AC0DU4_001762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HIN4237687.1"
                     /translation="MAEAKKKQIPLRLSTKLYAALASWAE"
BASE COUNT         2657 a         1751 c         1296 g         2520 t
ORIGIN      
        1 tctgagtcaa agaccttagc tggcccaacg tgacgacgca ctttaacacc tgataccttg
       61 gcaactgcac cgtcaggagc aaggttcccg ttcaagatga taagcggacc atccgcacgt
      121 tttggatttt caagtggcat gataactttt tggcctggag tcaagtctgc aaagtcagcc
      181 aagttttcag ctacagtctt accagtacat gtgatgcgat ctccgtgaag gaaaccattt
      241 gccaacaagt acttcataac cgcagggaca ccaccgactt cgtagaggtc ttggaagaca
      301 tactgaccag atggtttcaa gtcggccaag tgaggcacac gttcttgaat cgtattgaag
      361 tcctcaagtg acaagtcaac atttgcggca tgggcaatgg cgagcaagtg aagagtggcg
      421 tttgtagaac caccgagagc catcgttaca gtaatagcat cttcaaaggc ttcacgagtc
      481 aagatatctg atggtttgag accaagttcc aacatcttaa caacagcacg tcctgctgct
      541 tcgatatctt ctttcttatc agctgattca gctgggtgag aggatgaccc tggcaaactc
      601 atccctagaa cttcgatagc agttgccatg gtattagcag tatacatacc accacaacca
      661 ccagggccag ggcaggcatt acattcaaga cgtttcacgt cctcagctgt catgtcaccg
      721 tggttccatt ttccgatacc ttcaaagaca gaaaccaagt cgatatcttt accatcaaga
      781 tttcccggtg caatagttcc accataggcg aaaatagctg ggatatccat attagcaata
      841 gcaatcatag atccaggcat gttcttgtca cagccaccga tagcgacgaa ggcatccacg
      901 ttgtgaccac tcatagccgc ctcgatggag tccgcgatga tgtcacgaga tgttagagag
      961 aaacgcatac caggcgttcc catagcgatc ccgtccgcta cggtaatggt tccaaactgt
     1021 acaggccaag cgcctgcaga tttgacacct tctttagcca gtttcccgaa atcatgcaag
     1081 tgaatgttac atggtgtatt ttccgcccaa gtcgaaatca ctcccacaat cgatgtttca
     1141 aagtccttat ctgtcatacc agtcgcacga agcatagcac ggttaggtga tttaaccatg
     1201 ctgtcataaa tgctactgcg gtgacgttta tctaattcag tcatcttatc cctcccattt
     1261 cagtttttac tattatagca caatttaaag gcaatgaaca gaataaaatt cttgaatttt
     1321 cagaaaattc tatacgcatg tgaaatattt aaaattaaaa acaacaaagc ggattagtgc
     1381 actttctgat gaccagaata tgctttttaa tccgctttct ttaaataacg tactgtaatt
     1441 tttacagaaa ttctttcaga taagtgtatt taacatctat cttgcattat aaatttctag
     1501 aaccttctct tttatattcg attcactcaa accatactca ttaagaagat aatccatttt
     1561 ccctacttga ccgaatcttt cttgaacacc catccgatga atttttgtta ttccatcatc
     1621 agagaataat tcacataaag cactgccaat tccacctatc tgattgtggt tttctacagt
     1681 aaatatagtt tttccactta acattgtttt tatctgttct ggtatcggtt tgattctaaa
     1741 taaatctatc acacctactg aataacctaa tttagacagt tcatctgcaa ctcgaatact
     1801 tggagcaacc attatgccag aagcaacgat tacaagatct tcaccatgtc ttaactcaat
     1861 gtagccctta gaaaaatctt ctccaccttg atatacagcc tctggagctt ttctaattgt
     1921 tcgaatatat tttagtcctt ttaagtctaa tgtctgattc aatatttcac gaaattggat
     1981 atcatcagtt gcttcaaaaa tgattgattt aggaattaaa cgtaacaatc caatttcttc
     2041 aaatggcata tgtgtcccac cattcatttc tgcagttact cctgcatctg atccaatcac
     2101 agtggcatcc aattgtgcgt atccaagaga aataaataat tgatcaaata ctcttcgtga
     2161 agcaaaagga ccaaatgtat gaagataagg tctaaacccc tgaatagaca agcctgctgc
     2221 aaggccgacc atttctgctt ccataatccc aacattcaca taacggtctc caaagttctt
     2281 ttcaagatta ttagtagcca tcgaacttga caaatcggct tctaagacta ctatatcaga
     2341 ataactttga ttagcctcta aaaggaagtc tctatataca tgccgtaatt ctttcgtact
     2401 tctcatcatt ctgtttcctc caattcctga cttaatcttt ctacaactga agttaacatt
     2461 tgtttctcct ctacagtagg gcgaagatga tgattggatt tcatttcttc cagctcttga
     2521 accccttgac ctttaatagt atctaataca atgcacttag gtgatgaatt atttgactgt
     2581 tttaattgga caatcccttc ataaatttct ctaatatctg aacccttgac cctaatggat
     2641 tcaaatccaa atgctgaaaa tttttctacg aaatcacctg gattacaaat atcctttgta
     2701 aaaccatcta attgtttttt gttatcatca acaaatacaa ttaagttgga taactgttga
     2761 tgagaagcaa actgtatagc ctcccaacat tgtccctcat ttaactcacc atctccaaca
     2821 atagcataag tataaaaggg actctttctt attctctgac catatgcaag tccagttgca
     2881 acactaattc cttgtcctaa agagcccgtt gtcatatcta tgcctggcgt tagatttcta
     2941 tcaggatgag acggtaattt ggttccattt gtatttaaag aatataagaa ttctttgtca
     3001 aagaaaccat tcaaatagag tgtactgtat agagctggtc ctccatgacc ttttgataat
     3061 atgaaataat ctctatctcg tgctgcaaat atttctggag tcattggcat tatttcacca
     3121 taaagcactg ctaaaacttc tacgatagac agacttcctc cgtaatgtcc gaatccaaga
     3181 tgattcaatg ttctaagagt atttaatcgg atgttagtcg caaattttct taacccatct
     3241 tctctatttt tacttaaaat catcccttat tcctcctttg cagatggctt tttaataaag
     3301 gatactccaa acataactgc tagaataaga acaagaccaa tcacaatacc tgcttgtgag
     3361 ccaaattgat ttaacattcc taaaataatt cctgatagac caaaatctgc atctgagaaa
     3421 gttgatcctt ggaaaccaag tcctcccaaa actggcatta aaaagactgg aagaaaactg
     3481 attaaaatac cttgtaaaaa tgctccaata gtggcgccac gaacaccacc agatgcattc
     3541 ccaatgacac ctgcagtcgc tccacagaag aaatgaggca caacacctgg taagataaca
     3601 accgttcctg aagcaatcat aattgccata cttactaaac caccaacaaa actagagata
     3661 aatccaatta gaactgcatt gggtgcataa gtataaacaa tcggacaatc caaagcaggt
     3721 tttgaattag gtacaagacg ctctgaaata cctttaaagg ctggaacaat ttcgcccaaa
     3781 ataaggcgaa cacctgctaa aataacaaat acccctgctg caaattgacc tgctaattgt
     3841 aaagcataaa ctagaccact tgtaccacta ctgatttctt tttctatata ttctgaccct
     3901 gcaaagatag ctacaataat gtaaataact gccatagata aagtgatact aacagtacta
     3961 tcacgtaaaa aagctaaact ctttggaaat ttaatgtcct ctgttgattt tgatttgtca
     4021 ccgataaggc taccagtaaa accactcaac caatatccca aagaactgaa atgacctaaa
     4081 gccaccttgt catttccagt taattgaacc atatattttt gcacaaatgc tggggaaata
     4141 ctcataataa taccgagtgc taatcctcct agtaagatga gaggcaagct agtaaagcca
     4201 gcaactgata aaatgaccgc aatcatacat gccatatata gagtgtggtg ccctgttaaa
     4261 aaaatatatt taaatcgagt aaaacgagcg attaagatat tgaacaccat gcctgcaaac
     4321 ataatcattg cagtagctga gccatatgtt gttaaagcta cagctacaat tgcttcatta
     4381 ttcggcacaa cgccagataa atgaaaagca tgctcaaaca tggtaccaaa tggatttaaa
     4441 gaattttgta caattcctgc accaccagat acaactaaga aaccaacaaa ggtcttaatt
     4501 ccacctttaa taatatcagg taatttcttc ttctgaagaa ctaatcctaa aattgcaatt
     4561 aaagctacta aaatagctgg tgtactaaca atatccaata tgaacttcat catgacgcta
     4621 gcctcctata taagtccttt ttcttcacaa agtttagtaa ttaattctcg tagttcatcc
     4681 atatcaataa tactatttaa gatacgaaca tctccaagat gactagctga atcagctaga
     4741 tcacgaccaa caatccaaat atcagctgca tttggatctg ctccacctaa atcataatgt
     4801 tcaacttcta catccgaaac attcaaatca ctcaatacag attcaatatt catctgtacc
     4861 ataaaacttg aacctaatcc tgaaccacaa gctgtaccaa tttttaacat tatctaatcc
     4921 tcctgtttaa ttatcatttt aatgtcatca tagttttttg atgatattaa agtttgaaca
     4981 tgatttttat ctcttaaaat tgttgttaaa tgtgacaaag cctttaaatg actctcatta
     5041 tcaatggctg caatacaaat caacaatctt acctcttgtt ctggattatc caataaataa
     5101 atcggttctt ccaaaactaa cattgacatt cctatttcat tcacaccttc atctggccga
     5161 gcgtgaggaa ttgctactcc cttccctaaa ttaataaaag gtccaaactc ttctactttt
     5221 tgaatcattg cctcagggta gttctcagtt atcttatctt gatccaaaag cggtttagct
     5281 gctaaacgaa tcgcctcctt ccatcctaat ttttgcgaac taacctgata ggtttctttg
     5341 gtaataagtt gttctagcac tggtacaatt tcctttctat catttttttg gtaaagataa
     5401 ttctttaacg ccaatcttaa ttccaattct tgtgtaataa ttccatatct tttgacaata
     5461 ttcaggattt gttcaatctc aaaatctcca tactctaaat tcggaaaatc ttttaacact
     5521 agttctacta gttgtattgc ttgctcttca gtcatcataa ccgaaactag ataatttggc
     5581 ttttctgtct ccacctttat ggtagaaaaa accatatcat agtcactact agctttcacc
     5641 tgtaaatcat caatctttga ggttcctata aactcaattt gaggaaataa tgctaataga
     5701 ttctctttta acatcaatga agaactaaca ccattaggac aaatgattgc tgctttatag
     5761 catttttgag gcaaagtatc tgctttcttt aaataacctc cgaaatggat aacaaaatat
     5821 gctgtttcac tatcaggtat gggattgtca atagcgtcca tcaagggcat caaagaatct
     5881 ttgactaatt caaataaatc aggataatgt tctttaacat gcaatacata ttcatttgaa
     5941 ctaggtaggc cgaactttaa tctatagtaa gccggtataa ggtggcggcg aagattttct
     6001 ctcaatcctt ccctttgttt aaaatgtaac aaagaaatat cttccattct acttataata
     6061 gcctctgtta attgattaaa gtaaaccgga gcaacatcta cttcaccttc aaagcaactt
     6121 gataataaaa ctgtgatata gcgataatca tcctcagaaa acaccgtatc tataattccc
     6181 aaatcaacca ctgtatccaa taaaatagtg gttatatctt gaataacagg agatactaat
     6241 gtctctgaaa gacatactct ttcaacatcc ctttgatacc tacacagaat gaatactaaa
     6301 ccgaaaaggc aaacttttaa ttgattaaca ataggtacta gttgtagctt ctcataataa
     6361 tctttaacta cctgatttat caaatcataa gttaatgaat acccccaact ggataaaaca
     6421 taatccaaac cccaaatccc tatggaggat tccagcaact cactaaccat ttgaaaagct
     6481 aagcggtgct tattccactc tgaaccgtgt aaagtataac cttttgctct actgtaccct
     6541 agctccaaat cattatctaa cataatcttt cttaatgatt gaatatcaga taaggttgta
     6601 ttcttactta ctttcaaaaa gtcttggtaa tgattattcg atataaaatc taatcggcaa
     6661 aaagtgtaaa gatagattaa agctaagcga gtcgactttg gtaaaaccaa ttcatccgac
     6721 ttaataatat ctgtcaaaga ctgcttcgta cgatttgata aactatagcg accttgtttt
     6781 ttatccagca ctatcccttt attagctaga taaggcacta aataatctat tccttctttg
     6841 acttccttta taggtaagct caccttaaca gataattcat ataatgatag ctcacaatga
     6901 tccatcaaag tcatcaaaat aactagtgct ctataatcaa acatttctct tcctttctaa
     6961 ctacaattat agtgtaaaaa ttataagaat aaaagagtat ttgagcacaa tataatctca
     7021 ccttttaaaa gaaattattg ggctgaaagt ttttagtgat tattttcaac tttctattga
     7081 cttttaaaaa caaagtgata tcatttagat atcaaataat gggaggtcat tcttatgact
     7141 gaaaaactaa tcaattcaaa accaaatggt gtattcgcat tgattctcat tgagttgaca
     7201 atcgtacttg gtgtctttat atttataatg ggtgttggtt cggaaaacat ttttggaatt
     7261 attatcggac ctttactaat cgtaattgca ggtctagctc atgctggttt aaaagttgtc
     7321 aaacctcagg aagctctggt tctgacactc tttggtaatt atacaggtac catcaaagaa
     7381 cctggttttt actttgtcaa tcccttcagc gtagcagtca accctgcaaa ccacactcga
     7441 cttggacaaa gtggtgatgt tagcacaaaa tctccttttt taggagctaa atcatcaaat
     7501 gacaatgatg taaatcttga aattggcaag aaacacattt ccctcaaagt catgaccttg
     7561 agcaattctc gtcaaaaaat caatgattgc ttaggaaacc ctgtagaaat cggtatcgcg
     7621 gtaacttgga gagttgtcga taccgctaag gcagtcttca acgttgataa ctacaaagaa
     7681 tatctttcac tgcaatgtga tagcgccctc cgtaatattg tccgcatcta tccttacgat
     7741 gtgtctccta atgtggatac tacgggtgac gggcaagcag atgaaggtag tctccgtggc
     7801 tctagcgaaa ttgttgctaa ccgtattcgt gaagaaatcc aaagtcgtgt tgaggatgct
     7861 ggcttggaaa tccttgaagc acgtatcact tacctagctt atgctccaga aattgctgcc
     7921 gttatgcttc aacgccaaca agcatctgcc attattgatg cacgtaagat gattgtagat
     7981 ggtgctgtag gaatggttga aatggcacta gaacggctca atgaagggga attggtagaa
     8041 cttgacgaag aacgaaaagc tgccatggtt tcaaatctcc ttgtcgttct ttgtggcaat
     8101 catgatgcac aaccaattgt caacacagga agtctttact aaagatggct gaagctaaaa
     8161 aaaagcagat cccccttcga ctctcaacaa agttatacgc tgcactcgca tcatgggcag
     8221 aaga
//
LOCUS       DBMVGT010000069         8123 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.069, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000069 DBMVGT010000000
VERSION     DBMVGT010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 8123)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8123)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8123
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.069"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..533)
                     /gene="rpe"
                     /locus_tag="AC0DU4_001763"
     CDS             complement(<1..533)
                     /gene="rpe"
                     /locus_tag="AC0DU4_001763"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004750 - D-ribulose-phosphate 3-epimerase
                     activity [Evidence IEA];
                     GO_process: GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HIN4237688.1"
                     /translation="MSQYKIAPSILAADYANFEREIKRLEATGAEYAHIDIMDSHFVP
                     QISFGAGVVESLRPHSKMVFDCHLMVSNPEHHLEDFARAGADIISIHVEATPHIHGAL
                     QKIRSLGVKPSVVINPGTSVEAIKHVLHLVDQVLVMTVNPGFGGQAFLPETMDKVREL
                     VALREEKGLNFEIEVDGG"
     gene            complement(544..1422)
                     /gene="rsgA"
                     /locus_tag="AC0DU4_001764"
     CDS             complement(544..1422)
                     /gene="rsgA"
                     /locus_tag="AC0DU4_001764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_function: GO:0043022 - ribosome binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HIN4237689.1"
                     /translation="MQGQIIKALAGFYYVESDGQVYQTRARGNFRKKGHTPYVGDWVD
                     FSAEENSEGYILKIHERKNSLVRPPIVNIDQAVVIMSVKEPDFNSNLLDRFLVLLEHK
                     GIHPIVYISKMDLLEDRGELDFYQQTYGDIGYDFVTSKEELLSLLTGKVTVFMGQTGV
                     GKSTLLNKIAPDLNLETGEISDSLGRGRHTTRAVSFYNLNGGKIADTPGFSSLDYEVS
                     RAEDLNQAFPEIATVSRDCKFRTCTHTHEPSCAVKPAVEEGVIATFRFDNYLQFLSEI
                     ENRRETYKKVSKKIPK"
     gene            complement(1424..2296)
                     /gene="rsmA"
                     /locus_tag="AC0DU4_001765"
     CDS             complement(1424..2296)
                     /gene="rsmA"
                     /locus_tag="AC0DU4_001765"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000179 - rRNA
                     (adenine-N6,N6-)-dimethyltransferase activity [Evidence
                     IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HIN4237690.1"
                     /translation="MRIADYSVTKAVLERHGFTFKKSFGQNFLTDTNILQKIVDTAEI
                     DDQVNVIEIGPGIGALTEFLAERAAQVMAFEIDHRLVPILVDTLRDFDNVTVVNEDIL
                     KVDLAQHIQNFKNPNLPIKVVANLPYYITTPILMHLIESGIPFSEFVVMMQKEVADRI
                     SAQPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRPEPAVAVED
                     ENFFFKVSKASFTHRRKTLWNNLTGYFGKTEEVKDKLTKALDQAGLSPSVRGEALSLA
                     EFAGLADALKGQGL"
     gene            complement(2682..2828)
                     /locus_tag="AC0DU4_001766"
     CDS             complement(2682..2828)
                     /locus_tag="AC0DU4_001766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237691.1"
                     /translation="MCEKIRIRRVSDYPSARGGLEDKNMTNHLLLVQILVHGYLLDFA
                     SIEG"
     gene            complement(2821..3462)
                     /locus_tag="AC0DU4_001767"
     CDS             complement(2821..3462)
                     /locus_tag="AC0DU4_001767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237692.1"
                     /translation="MIDIQGLEKKFNDRAIFSGLNLKLEKGKVYALIGKSGSGKTTLL
                     NILGKLEKIDGGRVLYQGKDLKTIPTREYFRDQMGYLFQNFGLLENQSIKENLDLGFV
                     GQKISKVERLERQVGALEKVNLGYLDLEQKIYTLSGGEAQRVALAKTILKNPPLILAD
                     EPTAALDPENSEEVMNLLVDLKDENRIIIIATHNPLVWNKADEIIDMRKLAHV"
     gene            complement(3464..5494)
                     /locus_tag="AC0DU4_001768"
     CDS             complement(3464..5494)
                     /locus_tag="AC0DU4_001768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HIN4237693.1"
                     /translation="MKRLFILISMVLVSLYMVITSVDHREEILFGNYPSVDVTGMMIN
                     QPVASREEVTEALSHLAVEHNSLIARRIVEPNEAGETRFTYATYGEGKLPEGLTISSK
                     ESAETSDLLGSYLIVSGSLDGVSLQTTLKELGYQGFVSNGEDPFSIVLLLTATPMVLL
                     SLAIFLLTFMSLTLIYRIKSLRQAGIRLIAGESLFGVALRPVLEDVRQLICSVLVSSL
                     LGLGILWYQGALFMATVQLVIIALLLYGLTLAGISTLLSVVYLLGLQENSLVDLLKGK
                     LPLKRMMTLMMVGQLLAVLVVGSSATALLPHYREMQEMERASNKWSQSSDRYRLSFGW
                     SSAFADEEGTRKDNREWQTFTEERLANTDSFYIMSNVDNFSDGAEVDLDGNRLSDYTP
                     SGNVIYVSPRYLIEEKITVSSEFMDKMQNLSEGEFGLILPESLREQSVYYQGLFTDYL
                     QNFSSESVEVTSQKHYLPQVRLAFTETGQERFLYNDGYKTTRQYLKDPIIVVLTPQAT
                     GTRPVAGMLWGTTANSALKLDRYGDSITALKEQGLYHKVSYLVKSQLFFAKVLNDKRV
                     EFYSLLIGTILTLSTAILLFDSMNLLYFEQFRRELMIKRLAGMTIYELHGKYLLAQGG
                     VLLLGLVLSSILTRDGLISALVVALFTLNALLILVRQDKKEEAGSMAVLKGK"
     gene            complement(5571..5867)
                     /locus_tag="AC0DU4_001769"
     CDS             complement(5571..5867)
                     /locus_tag="AC0DU4_001769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000815395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HIN4237694.1"
                     /translation="MKQTVKKLALVASIAATLGGSVAVASAAVQYPEGGVWTYGSGNG
                     GAYSNYYHPSKYHSSTVVSRKTGSSDKGYAGAGGTSRAWIRTSWGEKVAFYYNV"
     gene            complement(6187..7086)
                     /locus_tag="AC0DU4_001770"
     CDS             complement(6187..7086)
                     /locus_tag="AC0DU4_001770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HIN4237695.1"
                     /translation="MLIGQKIKEIRIEKGISRPDFCGDEQELTVRQLSRIESGASQPS
                     LPKLAYIARRLGVPVYSLMPDFSALPSAYLELKYQILREPIYGKEEEYDKKEACLEEI
                     YKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLL
                     IRLFFYQMLIRKDLAKFINQIEKLMLFLLEQKKVTQIENYFIIRDTLISGMCCLEKVG
                     VTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAK
                     LIGDGFLVKKLTEEWQEDVKKYL"
     gene            complement(7158..7718)
                     /gene="rnmV"
                     /locus_tag="AC0DU4_001771"
     CDS             complement(7158..7718)
                     /gene="rnmV"
                     /locus_tag="AC0DU4_001771"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043822 - ribonuclease M5 activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HIN4237696.1"
                     /translation="MKERISQVIVVEGRDDTVNLKRYFDVETYETRGSAINDQDIERI
                     QRLHQRHGVIVFTDPDFNGERIRRMIMTAIPTVQHAFLKRDEAVPKSKTKGRSLGIEH
                     ASYEDLKTALAQVTEQFEHESQFDISRSDLIRLGFLAGADSRKRREYLGETLRIGYSN
                     GKQLLKRLELFGVTLAEVEEAMKSYE"
     gene            complement(7718..>8123)
                     /locus_tag="AC0DU4_001772"
     CDS             complement(7718..>8123)
                     /locus_tag="AC0DU4_001772"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004536 - DNA nuclease activity [Evidence
                     IEA];
                     GO_function: GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HIN4237697.1"
                     /translation="PFVVHTRDALEDTYEIIKSEGVGPRGGIMHSFSGTLEWAEKFVD
                     LGMTISFSGVVTFKKATDLQEAAKELPLDKMLVETDAPYLAPVPKRGRENKTAYTRYV
                     VDFIADLRGMTTEELAVATTANAERIFGLDSK"
BASE COUNT         2341 a         1929 c         1468 g         2385 t
ORIGIN      
        1 ccaccatcca cttcgatttc aaagttcaaa cctttttcct cacgaagagc aaccaactca
       61 cgaaccttat ccatggtttc tggcagaaag gcttgcccac caaaacctgg attaaccgtc
      121 atgactaaaa cttggtcaac tagatgaagg acgtgcttga tggcttcaac tgatgtgcca
      181 ggattgataa cgactgaagg cttaactccg agtgaacgaa ttttttggag ggcgccatga
      241 atatgaggcg ttgcttctac atggatactg atgatgtctg cacctgcacg cgcaaaatct
      301 tccagatgat gctcagggtt tgacaccatc aagtggcaat cgaaaaccat cttactatga
      361 ggacgaaggc tctcgaccac acctgcacca aaactgattt gcggtacaaa atgactgtcc
      421 atgatatcga tatgggcata ttctgcccca gttgcttcta gacgtttgat ttcacgttca
      481 aagttggcat aatctgctgc cagaattgac ggagcaatct tgtattgaga cataggtttc
      541 tccttatttt ggaatttttt tgctgacttt tttataggtt tctctacgat tttcaatttc
      601 actaaggaat tgcaggtaat tgtcaaaacg gaaggttgca ataacaccct cttcaacagc
      661 tggtttgacg gcacaagacg gctcatgggt atgggtacaa gtacggaact tacaatctcg
      721 gctaacagta gcaatctctg ggaaagcctg attgaggtct tcagcccttg atacttcata
      781 gtccaaggat gaaaatcctg gtgtatctgc gattttaccc ccgttgagat tgtaaaaact
      841 aacagctcga gtggtatggc gaccgcgacc tagactgtct gaaatttctc ccgtttcaag
      901 attgaggtct ggtgcgattt tattgagaag agttgacttc ccaacacctg tctgccccat
      961 aaagaccgta accttgcctg ttaacaaaga caggagttcc tctttactgg tcacaaagtc
     1021 atagccgatg tcaccatagg tctgctggta aaaatccagt tctcccctat cttccaacaa
     1081 atccattttg gaaatataga caatgggatg gatgcccttg tgctccaaaa gaaccaagaa
     1141 acgatccagc aaattgctgt taaaatcagg ttccttgacg gacatgatta ctacagcttg
     1201 atcgatattg acaataggcg gacgaaccag actgtttttc cgttcgtgaa ttttgaggat
     1261 atagccttct gaattttcct cggcagagaa atctacccag tccccaacat aaggggtatg
     1321 gcctttttta cggaaattcc cacgcgcgcg tgtttgataa acctggccat cactctccac
     1381 atagtagaaa cctgccaagg ctttaatgat ttgtccctgc atcttagagt ccttgccctt
     1441 taagtgcgtc tgctagaccg gcaaattctg ccaagctgag agcttcccca cgcacacttg
     1501 gtgacaagcc tgcctggtcc aaagccttgg tcagcttgtc cttgacctct tcagtcttac
     1561 caaagtaacc tgtcaagtta ttccacaagg tcttgcggcg atgggtaaaa ctagccttgg
     1621 aaaccttaaa gaaaaagttc tcatcttcta ctgctacggc tggctctgga cgacgcacca
     1681 ttttcaagat ggctgaatcc acatttggcg ctggcacaaa gaccgtacga ggcacgataa
     1741 aggcaacctt ggctgtcatg taatactgca cggcgataga caagctaccg taagccttgg
     1801 tgttaggctg ggctgaaatg cggtccgcta cttctttctg catcatgacc acaaactcac
     1861 taaaaggaat gccactctca atcaagtgca tgagaatagg cgtcgtgatg tagtaaggca
     1921 aattagccac taccttgatt ggcaggttag gatttttaaa attttggata tgttgcgcca
     1981 aatcaacctt gagaatatct tcgttaacta cagtcacatt atcaaaatca cgcagggtat
     2041 ctaccaaaat tggcaccaaa cggtggtcaa tctcaaaagc catgacttgg gctgcacgct
     2101 cagccagaaa ctccgtcaag gcaccaatac ctggcccgat ttcgatgaca ttgacctggt
     2161 catcaatttc agccgtatcc acaatttttt gaaggatatt ggtatccgtc aggaaatttt
     2221 gcccgaagga ctttttaaag gtaaaaccgt gacgctccag cactgccttg gtcacgctat
     2281 aatctgcaat tctcatctat tctcttttct attatctgtt actactattg taacacattc
     2341 cccttgtatt ttgggaatga aaatcatacc aaaaaactat ctttcctcat gaagaaagat
     2401 agtcttggaa atctttaaaa gtggccttaa cagttctctc gaaacatgcg ttcatactct
     2461 tcgaaaatct cttcaaacca cgtcagcttc accttgtcgt actcaagtac agcctgcggc
     2521 tagcttccta gtttgctctt tgattttcat tgagtatcaa aaaaatcagc ttcttgataa
     2581 cttctatttt cgggtagggt caaatccaca tcctcctcca catcatccac tgtcagttca
     2641 accgtttgag gtaaattttt caaacgataa tgcttttgcc tttacccttc aatactagca
     2701 aaatcaagca aatagccatg cactaggatt tgaaccaaaa ggagatgatt ggtcatattt
     2761 ttatcttcta aaccacctct ggcactagga taatcagata ccctgcgaat acggattttt
     2821 tcacacatga gcaagtttcc tcatatcaat gatttcatca gccttattcc agactagggg
     2881 attatgggtc gcaatgatga taattcgatt ttcatctttc aaatccacca agagattcat
     2941 aacctcctct gaattttcag gatcaagagc tgctgttggt tcatctgcca aaatcaaggg
     3001 tggatttttc aaaatagttt ttgcaagggc aactcgttgg gcctctcccc cagataaagt
     3061 atagattttt tgttctaaat ccaaataccc tagattaact ttttctaaag cccccacttg
     3121 cctttccaaa cgttctactt ttgagatttt ctgaccaaca aaacccaaat ccaaattttc
     3181 tttgattgat tggttttcta agaggccgaa attttgaaag agatagccca tctggtctcg
     3241 aaaatactca cgagtaggaa tggtttttaa atctttcccc tgatagagaa cccttccacc
     3301 atctatcttt tctagctttc ccaagatatt cagcagcgtc gtctttccgc ttccactctt
     3361 tccgattaag gcataaacct tgcccttctc cagcttgaga ttcaaaccag agaaaatcgc
     3421 gcggtcatta aatttctttt ccaatccttg aatatcaatc atcttatttt cctttcaata
     3481 ctgccatgct accagcttct tcttttttgt cctgccttac taaaatcaag agggcgttaa
     3541 gcgtaaacaa agctacaact agagcgctaa tcaaaccatc tcttgtcaaa atactagata
     3601 ggactaggcc aagcaagaga actcctcctt gcgccagtaa atacttgcca tgaagttcat
     3661 agattgtcat accagcaaga cgtttaatca taagctcccg tctgaactgc tcaaaataga
     3721 gaagattcat ggaatcaaat aacaagatag ccgtagacag ggtcaaaatc gtcccaataa
     3781 ggagagagta aaactccacc cgtttgtcat ttagtacctt ggcaaaaaat agctggcttt
     3841 ttaccaagta agaaaccttg tgatacagac cttgctcttt tagagctgtg atgctgtctc
     3901 catatcgatc tagtttcaag gcactattag ccgtagttcc ccacaacatc cctgcaacag
     3961 gtcttgttcc agtcgcttgc ggcgttagaa ctacaataat cggatctttt aggtactggc
     4021 gtgttgtctt gtacccatca ttatagagga aacgttcctg tcctgtttct gtaaaagcta
     4081 gccttacctg tgggaggtag tgtttctgac tcgtcacttc tacactttca gatgaaaagt
     4141 tttgcaggta atctgtaaac aatccttggt agtagacaga ctgctctcgc aagctctcag
     4201 gcaagatcag cccaaactct ccctcagaca agttttgcat cttgtccata aactctgaag
     4261 aaacggtaat cttttcttct atcagatagc gtggtgagac atagataaca ttccctgacg
     4321 gtgtgtagtc actgagacga ttgccatcta ggtccacttc tgctccatct gagaaattgt
     4381 caacattgct cataatataa aaagagtctg tattggctaa ccgttcttca gtaaatgtct
     4441 gccactcacg attatcctta cgcgttcctt cttcatcggc aaatgcacta gaccaaccaa
     4501 aggatagacg gtaacggtct gaggactggc tccatttatt gctagctctc tccatttcct
     4561 gcatttcacg gtagtggggt aggagagctg tcgcactcga tccgaccacc aatacagcta
     4621 agagttgccc caccatcatc aatgtcatca tacgtttgag agggagtttc cctttcaata
     4681 gatccaccag actattttcc tgtaaaccaa gtagatagac gacacttagt aaggtagaaa
     4741 tccctgccaa ggtcaatcca taaagtagaa gagcaatgat gaccagttgc accgttgcca
     4801 taaacaaggc accttgatac cagagaatcc ccaatcccaa aagactggat accagcactg
     4861 agcagataag ctgtctcaca tcttctaaca ctggtctgag agcaactcca aacaagctct
     4921 caccagctat taagcgaatc cctgcctgac gaagggattt gatccgataa atcagggtca
     4981 gactcataaa ggtcagcaga aaaatagcta aactcagtag caccataggg gtggccgtca
     5041 atagtaagac tatcgaaaat ggatcttctc cattcgaaac aaagccttga taaccaagct
     5101 ctttcaaggt ggtctgtaag ctcactccat ccaaacttcc tgacacaatc aagtaagacc
     5161 ctaataaatc actcgtttct gcactctcct tggaggaaat ggtcagacct tctggaagct
     5221 ttccctcacc ataagtggca taggtaaagc gtgtttctcc agcttcattt ggctcaacga
     5281 ttcgacgagc aatgagacta ttgtgctcta ccgccaagtg actcaaagcc tctgtcacct
     5341 cttcccgact agctactggt tgatttatca tcattcctgt cacatcaaca gaaggatagt
     5401 taccaaataa aatctcttct cgatggtcaa cggaagttat caccatataa agcgatacca
     5461 ataccattga aatcaaaata aataaacgtt tcatcatttc ctccaaaaag ttacttggtc
     5521 acttagtgag aaggtgacca agtaaagcta aacaataggg ctataccatt ctaaacatta
     5581 tagtagaatg caactttctc tccccaagaa gtacgaatcc atgcacgaga agtccctcca
     5641 gcaccagcat atcccttgtc agatgaacca gtttttctgc taacaactgt tgaactatgg
     5701 tattttgaag ggtgatagta gtttgagtaa gcaccaccgt tacctgaacc ataagtccaa
     5761 acaccacctt ctgggtattg aacggctgca gaggcaactg ctacacttcc acctaatgtt
     5821 gctgcaatgc tcgctacaag agctaatttt ttaactgttt gtttcatatt gatactcctc
     5881 tatttttgat tacaagattg ttgagttact tgctcctctt tccattatca acgttgatac
     5941 tattatatta ccaaatgata ttctaaaatt atttgttttt ctctaaattg tcaaaatagc
     6001 accctgaaat gaacttttat agtcattata ctccatcttt atcacactat caaggacatc
     6061 aatgtcctta aaatctaact atttcatatt atttttagct tatatctaaa aaaacagttc
     6121 taaagacgaa ctttagaact gttttgatac gaggacaagg acatttttgt cactgattca
     6181 ctatgtttat aaatattttt tgacatcctc ttgccattcc tctgtcaatt tctttactag
     6241 aaatccatct ccaattagct tcgcaaatgt tttagaagac tgataaaatg attcagctaa
     6301 actaaaatct ctttctactc ttaatgcttg cttccacaaa aacataaata caagaggttt
     6361 cttttgataa tcttgagttt tatccataat ttcttgtaaa cacgatagat aatcattaaa
     6421 acaatcagtt actcctacct tttcaagaca acacattcct gaaataagag tatctctaat
     6481 tataaagtaa ttctctattt gagttacctt cttctgttcc aaaagaaaga gcattagctt
     6541 ttcgatttga tttataaatt tggcaagatc ttttctaatg agcatttgat aaaaaaacaa
     6601 acgaatcaac aacatatcat ttattgaata agcttctttt tctataatct gaggcatatg
     6661 ttcctcaagt attaactctg catattcagg ccttctagtt ctagaagtat ccaaacacgc
     6721 ctgcaatact tcacatgcta attgttcttc tttaggaaga ttatcaaagt atgttttata
     6781 aatctcttcc aaacacgctt ccttcttatc gtactcctct tctttaccat agattggttc
     6841 acgtaaaatc tggtatttca attctaaata agcagaagga agagctgaaa aatccggcat
     6901 aaggctataa actggaactc ctagccggcg agcaatatag gctaacttgg gcaaactcgg
     6961 ttgcgaagct ccactttcaa ttcgcgacag ttgacgaact gtcagttctt gctcatctcc
     7021 acaaaaatct ggacgactaa ttcctttttc tatccgaatc tctttaattt tttgaccaat
     7081 taacatcaga cgcctcctct tctacctgct tcgaaaaata ctgtgaaact taaaaaattg
     7141 taacggctac atctttccta ctcataagat ttcatagctt cttccacttc tgccaaagta
     7201 accccaaaca actctaggcg tttgaggagt tgcttgccgt tagaatagcc gattcggaga
     7261 gtctctccga gatattctct acgcttacgg ctgtctgccc ctgctagaaa accaaggcga
     7321 atcaaatcgc tacgactaat gtcaaactga ctctcatgtt caaattgttc tgtcacctga
     7381 gctagagccg ttttcaggtc ttcatagctg gcatgctcaa ttcccagaga acgccccttg
     7441 gtcttggact tgggaacagc ttcatctcgc ttgagaaagg catgctgaac tgttggaatg
     7501 gccgtcataa tcatgcgccg aatccgctcc ccattaaaat ctgggtctgt aaagacaatg
     7561 actccatgac gttggtgtag acgctgaatc cgctctatgt cctggtcatt gatggcagaa
     7621 cctcgagtct cataggtctc cacatcgaaa taacgcttga gattgaccgt atcatcacga
     7681 ccttcaacca cgataacttg ggaaattctc tctttcatta cttgctgtcc aatccaaaaa
     7741 tgcgttctgc atttgcagtc gttgctaccg ccagctcttc tgtcgtcata ccacgcaagt
     7801 cagcgataaa gtcgaccaca tagcgagtat aggctgtttt attttcacga ccacgcttgg
     7861 gtacaggtgc taagtaaggc gcatctgttt ctaccaacat cttgtccaaa ggtaactctt
     7921 tagctgcttc ttggaggtca gttgccttct tgaaggtcac cactcctgag aaggaaatgg
     7981 tcataccaag atccacaaac ttctctgccc actcaagcgt ccctgaaaat gaatgcatga
     8041 taccaccacg aggaccaacg ccctcactct tgataatctc ataggtatct tccagcgcat
     8101 cacgggtatg gacaacaaaa ggc
//
LOCUS       DBMVGT010000070         7927 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.070, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000070 DBMVGT010000000
VERSION     DBMVGT010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7927)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7927)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7927
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.070"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1019
                     /locus_tag="AC0DU4_001773"
     CDS             <1..1019
                     /locus_tag="AC0DU4_001773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0030983 - mismatched DNA binding [Evidence
                     IEA];
                     GO_process: GO:0006298 - mismatch repair [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="MutS-related protein"
                     /protein_id="HIN4237698.1"
                     /translation="SANLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAE
                     TQHLIRPEFGDDSQIDIRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLVTGPNMSGK
                     STYMRQLAMTAVMAQLGSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEAN
                     NAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLE
                     SSLQHLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILT
                     QLENQGTESPPPMRQTSAVTEQISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVEL
                     KQKL"
     gene            1166..2860
                     /gene="patA"
                     /locus_tag="AC0DU4_001774"
     CDS             1166..2860
                     /gene="patA"
                     /locus_tag="AC0DU4_001774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000908145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatA"
                     /protein_id="HIN4237699.1"
                     /translation="MLIQKIKTYKWQALASLLMTGLMVASSLLQPRYLQEVLGALLTG
                     KYEVIYSIGAWLIGVAVVGLVAGGLNVVLAAYIAQGVSSDLREDAFRKIQTFSYADIE
                     QFNAGNLVVRMTNDINQIQNVVMMTFQILFRLPLLFIGSFILAVQTLPSLWWVIVLMV
                     VLIFGLTAVMMGMMGPRFAKFQTLLERINAIAKENLRGVRVVKSFVQEKEQFAKFTEV
                     SDELLGQNLYIGYAFSVVEPFMMLVGYGAVFLSIWLVAGMVQSDPSVVGSIASFVNYL
                     SQIIFTIVMVGFLGNSVSRAMISMRRIREILDAEPAMTFKDIPDEELVGSLSFENVTF
                     TYPMDKEPMLKDVSFTIEPGQMVGVVGATGAGKSTLAQLIPRLFDPQDGAIKIGGKDI
                     REVSEGTLRKTVSIVLQRAILFSGTIADNLRQGKGNATLFEMERAANIAQASEFIHRM
                     EKTFESPVEERGTNFSGGQKQRMSIARGIVSNPRILIFDDSTSALDAKSERLVQEALN
                     KDLKGTTTIIIAQKISSVVHADKILVLNQGRLIGQGTHADLVANNAVYREIYETQK"
     gene            complement(3005..3459)
                     /locus_tag="AC0DU4_001775"
                     /pseudo
     CDS             complement(3005..3459)
                     /locus_tag="AC0DU4_001775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001857010.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            3647..5413
                     /gene="patB"
                     /locus_tag="AC0DU4_001776"
     CDS             3647..5413
                     /gene="patB"
                     /locus_tag="AC0DU4_001776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000859866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatB"
                     /protein_id="HIN4237700.1"
                     /translation="MKTVQFFWHYFKVYKFSFVVVILMIVLATFAQALFPVFSGQAVT
                     QLANLVQAYQNGNPELVWQSLSGIMVNLGLLVLVLFISSVIYMCLMTRVIAESTNEMR
                     KGLFGKLAQLTVSFFDRRQDGDILSHFTSDLDNILQAFNESLIQVMSNIVLYIGLILV
                     MFSRNVTLALITIASTPLAFLMLIFIVKMARKYTNLQQKEVGKLNAYMDESISGQKAV
                     IVQGIQEDMMAGFLEQNERVRKATFKGRMFSGILFPVMNGMSLINTAIVIFAGSAVLL
                     NDKSIETSTALGLIVMFAQFSQQYYQPIIQVAASWGSLQLAFTGAERIQEMFDAEEEI
                     RPEKAPTFTKLQESVEISHIDFSYLPDKPILKDVSISAPKGQMTAVVGPTGSGKTTIM
                     NLINRFYDVDAGGIYFDGKDIRGYDLDSLRSKVGIVLQDSVLFSGTIRDNIRFGVPDA
                     SQEMVEVAAKATHIHDYIESLPDKYDTLIDDDQSIFSTGQKQLISIARTLMTDPEVLI
                     LDEATSNVDTVTENKIQHAMEVVVAGRTSFVIAHRLKTILNADQIIVLKDGEVIERGN
                     HHELLKLGGFYSELYHNQFVFE"
     gene            5552..6241
                     /locus_tag="AC0DU4_001777"
     CDS             5552..6241
                     /locus_tag="AC0DU4_001777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HIN4237701.1"
                     /translation="MARTVVGVAANLCPVDAEGKIIHSSVSCRFAEIIRQIGGLPLVI
                     PVGDESVVRDYVEMIDKLILTGGQNVHPQFYGEKKTVESDDYNLVRDEFELALLKEAL
                     RQNKPIMAICRGVQLVNVAFGGTLNQEIEGHWQGLPFGTSHSIETVEGSVVAKLFGKE
                     SQVNSVHRQSIKDLAPNFRVTAIDSRDQTIEAIESIDEHRIIGLQWHPEFLVNEEDGN
                     LELFEYLLNEL"
     gene            6245..6424
                     /locus_tag="AC0DU4_001778"
     CDS             6245..6424
                     /locus_tag="AC0DU4_001778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237702.1"
                     /translation="MEHLVVLSFIFSKFLECGILRKRLNSDKNWRNSTKKLEKNEGKR
                     YDRKEEILEEEHVTY"
     gene            6411..7760
                     /locus_tag="AC0DU4_001779"
     CDS             6411..7760
                     /locus_tag="AC0DU4_001779"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004347 - glucose-6-phosphate isomerase
                     activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HIN4237703.1"
                     /translation="MSHIKFDYSKVLDKFVAPHEVEYMQSQVTAADELIRKGTGAGSD
                     FLGWLDLPEKYDREEFDRILKAAEQIKSDSDVLVVIGIGGSYLGAKAAIDFLNHHFAN
                     LQTKEERKAPQILYAGNSISSTYLADLVEYVADKDFSVNVISKSGTTTEPAIAFRVFK
                     ELLVKKYGQEEANKRIYATTDRQKGAVKVEADANGWGTFVVPDDIGGRFSVLTAVGLL
                     PIAASGADIKALMEGANAARKDYTSDKISENEAYQYAAVRNILYRKGYATEILVNYEP
                     SLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGTRIMFETVVRVDK
                     PRKNVLIPTLEEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGDVPNMYVTLPEQDAF
                     TLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKRNMFALLGKPGFEELSKELNARL"
BASE COUNT         2291 a         1575 c         1769 g         2292 t
ORIGIN      
        1 agtcagccaa cctcgaatac gaaatattta tgcgcattcg tgaagaggtc ggcaagtaca
       61 tccagcgttt acaagctcta gcccaaggaa ttgcgacggt tgatgtctta cagagtctgg
      121 cggttgtggc tgaaacccag catttgattc gacctgagtt tggtgacgat tcacaaattg
      181 atatccggaa agggcgccat gctgtcgttg aaaaggttat gggggctcag acctatattc
      241 caaatacgat tcagatggca gaagatacca gtattcaact ggttacaggg ccaaacatga
      301 gtgggaagtc tacctatatg cgtcagttag ccatgacggc ggttatggcc cagctgggtt
      361 cctatgttcc tgctgaaagc gcccatttac cgatttttga tgcgattttt acccgtatcg
      421 gagcagcaga tgacttggtt tcgggtcagt caacctttat ggtggagatg atggaggcca
      481 ataatgccat ttcgcatgcg accaagaact ctctcattct ctttgatgaa ttgggacgtg
      541 gaactgcaac ttatgacggg atggctcttg ctcagtccat catcgaatat atccatgagc
      601 acatcggagc taagaccctc tttgcgaccc actaccatga gttgactagt ctggagtcta
      661 gtttacaaca cttggtcaat gtccacgtgg caactttgga gcaggatggg caggtcacct
      721 tccttcacaa gattgaaccg ggaccagctg ataaatccta cggtatccat gttgccaaga
      781 ttgctggctt gccagcagac cttttagcaa gggcggataa gattttgact cagctagaga
      841 atcaaggaac agagagtcct cctcccatga gacaaactag tgctgtcact gaacagattt
      901 cactctttga tagggcagaa gagcatccta tcctagcaga attagctaaa ctggatgtgt
      961 ataatatgac acctatgcag gttatgaatg tcttagtaga gttaaaacag aaactataaa
     1021 accaagactc actagttaat ctagctgtat caaggagact tctttgacaa ttctccactt
     1081 ttttgctaga ataacatcac acaaacagaa tgaaaaggag ctgacgcatt gtcgctccct
     1141 tttgtctatt ttttaaggag aaagtatgct gattcagaaa ataaaaacct acaagtggca
     1201 ggccctggct tcgctcctga tgacaggctt gatggttgct agttcacttc tgcaaccgcg
     1261 ttatctgcag gaagtcttag gcgccctcct tactgggaaa tatgaagtta tttatagtat
     1321 cggggcttgg ttgattggtg tggccgtagt cggtctagtt gctggtggac tcaatgttgt
     1381 cctcgcagcc tatattgccc aaggagtttc atccgacctt cgggaggatg ccttccgtaa
     1441 aattcaaacc ttttcttatg ctgatattga acaatttaat gcgggaaatc tagtcgttcg
     1501 aatgacaaat gatatcaacc agattcagaa cgttgtcatg atgaccttcc aaattctttt
     1561 cagacttccc ctcttgttca tcggttcgtt tatcctagcg gttcaaacct taccttctct
     1621 gtggtgggtg attgttctca tggtagtctt gatttttggt ttgactgctg tcatgatggg
     1681 aatgatgggg cctcgttttg ctaaatttca aacccttctt gagcgcatca atgccattgc
     1741 caaggaaaat ttacgtggcg ttcgtgtggt caagtccttt gtccaagaaa aagagcaatt
     1801 tgctaagttt acagaggtct cagacgagct tcttggtcaa aacctttaca ttggttatgc
     1861 cttttcagta gtggaaccct ttatgatgtt ggttggttac ggggcggtct tcctctctat
     1921 ttggctggtc gcgggaatgg ttcagtcgga tccgtctgtt gttggttcca tcgcttcttt
     1981 tgttaattac ctaagccaga ttatctttac cattgttatg gttggatttt tgggaaattc
     2041 tgtcagccgt gccatgattt ccatgcgtcg tattcgagaa attcttgacg cagagccagc
     2101 tatgaccttc aaggatatcc cagatgaaga gttggttgga agtcttagct ttgaaaatgt
     2161 gacctttacc tatccaatgg acaaggaacc gatgctgaaa gatgtgagct ttactattga
     2221 acctggtcaa atggttggtg tagttggagc gactggtgca ggaaagtcaa ccttggctca
     2281 attgattcca cgtctctttg atccacagga cggggccatt aaaatcggtg gcaaggatat
     2341 tcgagaagtg agtgaaggaa ccctgcgtaa aacagtttcc atcgttctcc aacgtgccat
     2401 tctttttagt ggaacgattg cagataactt gagacagggg aaggggaatg ctactctatt
     2461 tgaaatggag cgcgcagcca atattgccca ggctagtgaa ttcattcatc gtatggagaa
     2521 aacctttgaa agtccagttg aagaacgggg aaccaatttc tctggtggac aaaaacaaag
     2581 gatgtcgatt gcgcgtggga ttgtcagcaa tccacgtatt ctgatttttg acgattcgac
     2641 ctcagccttg gatgccaaat cagagcgctt ggtgcaagaa gctttgaata aggacttgaa
     2701 ggggacgaca accattatta ttgctcaaaa aattagctcg gttgtccatg cagacaagat
     2761 cttggttcta aatcaaggac gattgattgg tcaaggcacg catgcagact tggttgccaa
     2821 caatgccgtt taccgtgaaa tctatgaaac acagaaatga aagacaaact ataagaaaag
     2881 tcaatagttt tatctaaact atttcttatt tcaatttgat gatttggcga tgattttaga
     2941 gcacggcaaa aagcccttga aaaagtccat tttttcaaag gtaatcctgt gttgatttca
     3001 gaaattacat cactttttgt tcgtcaaatg gcagctcttt tttaggatat aaaacagggt
     3061 tcggataagt ttttttgcaa ggtggatgat ggctacattg taatgttttc cttattctaa
     3121 cttagtctta agataggcct taaaagcagg tgaaaagcga gcgcatgctt tggcagcttg
     3181 tatgagtgcc taccgcagat gaggggaacc ccgtttgatc attcttccag ctaaatcaat
     3241 ctgacctgac tgataaatag aagaatccag tccagcgaaa gcttgtaatt gagcaggatt
     3301 atcaaaggca tgaatatttt gaatctcggc taaaatgacc gcccctaaac gattcccaat
     3361 cccagtaacc gtcgtgatga ccgaatttaa ctcagccatc aagtcattga cacatttttc
     3421 cgccttgtca atgagcctct tgtaatgttt gatgttttca ttacacgaga taaaacgtct
     3481 atgcgttatc aaactcatta ccaattaaaa caaatgtggt tagatccttt cggaaattgt
     3541 caagcgattg gaggaaatga actaatccac agcggcttat tccaagtata ccacttgggc
     3601 tttggcagta gctaactgcg ctaaatataa tataaggagg agtaaaatga agacagttca
     3661 atttttttgg cattatttta aggtctacaa gttctcattt gtagttgtca tcctgatgat
     3721 tgttctggcg acttttgccc aagccctctt tccagtcttt tctggacaag cggtgacgca
     3781 gctagccaat ttagttcaag cttatcaaaa tggcaatcca gaacttgtat ggcaaagcct
     3841 atcaggaatc atggtcaatc ttggcctgct ggttttggtt ctatttatct ctagtgtaat
     3901 atacatgtgt ctcatgacgc gcgtgattgc agaatcgacc aacgagatgc gcaaaggtct
     3961 ctttggtaag cttgctcagt tgacggtttc tttctttgac cgtcgacaag atggcgatat
     4021 cctgtctcat tttaccagtg atttggataa tatcctccaa gcctttaacg aaagcttgat
     4081 tcaggtcatg agcaatattg ttttatacat tggtctgatt cttgtcatgt tttcgagaaa
     4141 tgtgacgctg gctctcatca ccattgccag caccccattg gctttcctta tgctgatttt
     4201 catcgtgaaa atggcacgca aatacaccaa cctccagcag aaagaggtag ggaagctcaa
     4261 cgcctatatg gatgagagca tctcaggcca aaaagccgtg attgtgcaag gaattcaaga
     4321 ggatatgatg gcaggatttc ttgaacaaaa tgagcgcgtg cgcaaggcaa cctttaaagg
     4381 aagaatgttc tcaggaattc ttttccctgt catgaatggg atgagcctga ttaatacagc
     4441 catcgtcatc tttgctggtt cggctgtact tttgaatgat aagtctattg aaacaagtac
     4501 agccctaggt ttgattgtta tgtttgcaca attttcacag cagtactacc agcctattat
     4561 ccaagttgca gcgagttggg gaagccttca gttggccttt actggagctg aacgaattca
     4621 ggaaatgttt gatgcagagg aggaaatccg acctgaaaag gctccaacct tcactaagtt
     4681 gcaagaaagt gttgaaatca gtcatatcga tttttcatac ttgcctgata aacctatttt
     4741 gaaagatgtc agcatttctg cccctaaagg ccagatgaca gcagttgttg ggccgacagg
     4801 ttcaggaaaa acgactatta tgaacctcat caatcgcttt tatgatgttg atgctggtgg
     4861 tatttatttt gatggtaaag acattcgtgg ctatgactta gatagtctta gaagcaaggt
     4921 gggaattgta ttgcaagatt cggtcttgtt tagcggaacg attcgagaca atatccgatt
     4981 tggtgtgcca gatgctagtc aggaaatggt tgaggtagca gcaaaagcaa cccacattca
     5041 cgactatatc gaaagtttgc ctgataagta cgatactctt attgatgatg accagagcat
     5101 cttttcaaca gggcagaagc aattgatttc aatcgctcga accctgatga cagatccaga
     5161 agttctcatt ctcgatgaag caacttcaaa cgtagatacg gtgacagaaa acaagattca
     5221 gcatgccatg gaggtggttg tagcaggtag aactagtttc gtcattgccc accgcttgaa
     5281 aaccattctc aatgcagatc agattattgt ccttaaagat ggagaagtca ttgaacgtgg
     5341 taaccaccat gaacttttga agctaggtgg cttttattca gaactctatc acaatcaatt
     5401 tgttttcgaa taagaaagaa gttgtcctat gtgggcagct ttttcttgtc cataaaaaat
     5461 gtttatcaca gccttaaaaa aaacatatta gacgaaagtc attttgagtg atatgatagg
     5521 actatcgtta gcattcgaaa ggagaggcat catggctaga acggttgtag gagttgctgc
     5581 aaatctatgt cccgtagacg cagaaggcaa aatcattcat tcatctgtat cttgtagatt
     5641 cgcagagatc attcgtcaaa tcggtggtct ccctttagtc attcctgttg gtgatgagtc
     5701 agttgtacgt gattatgtgg aaatgattga caaactcatt ttgacaggag gccaaaatgt
     5761 tcatcctcag ttttatggag agaaaaagac cgtcgagagc gatgattaca atctggtccg
     5821 tgacgaattt gaattggcac tcttgaagga agcgcttcgt cagaataaac caattatggc
     5881 aatctgtcgc ggtgtccaac ttgtcaatgt tgcctttggt ggaaccctca atcaagaaat
     5941 cgaaggtcac tggcaaggac tacctttcgg gacatctcac tctattgaga cagtagaagg
     6001 aagcgtggtg gctaagctat ttgggaaaga aagtcaggtc aactcagtcc atcgtcaaag
     6061 cattaaagat ttggcaccta atttccgtgt aactgctatt gattcaagag accaaactat
     6121 tgaagcgatt gagtctatcg acgagcaccg cattatcggt ttacagtggc atccagagtt
     6181 tctggttaat gaagaagatg gcaatttaga attatttgag tatttattga atgaactgta
     6241 acgattggaa catctggtcg ttctttcttt tattttttca aaatttttag aatgtggcat
     6301 tttacgcaaa cgtttgaatt ctgataaaaa ttggagaaat tcgacaaaaa aacttgaaaa
     6361 aaacgaaggt aagcgttatg atagaaaaga agaaatattg gaggaagaac atgtcacata
     6421 ttaaatttga ttattcaaaa gttttagaca aatttgttgc accacatgaa gtggaataca
     6481 tgcaatcaca agtaacagca gcagatgaat tgatccgtaa aggaactggt gctggtagcg
     6541 acttcttggg atggttggac cttcctgaaa aatacgatcg cgaagaattt gaccgcatct
     6601 tgaaagctgc tgagcaaatc aagtcagaca gcgatgtttt ggttgtgatc ggtattggtg
     6661 gatcttacct tggtgcaaaa gcagcaatcg acttcttgaa tcaccatttt gctaacttgc
     6721 aaacaaaaga agaacgcaaa gctccacaaa tcctttacgc aggaaactca atctcatcta
     6781 cttaccttgc tgacttggta gagtatgttg cagacaaaga cttctcagta aacgtaattt
     6841 ctaaatcagg tacaacaact gaaccagcga ttgctttccg tgtctttaaa gaactcttgg
     6901 ttaagaaata cggtcaagaa gaagctaaca aacgtatcta tgcaacaact gaccgccaaa
     6961 agggtgctgt taaggttgaa gcagacgcta acggttgggg aacatttgtt gttccagatg
     7021 atatcggtgg acgcttctca gtattgacag ccgttggttt gcttccaatc gcagcatcag
     7081 gagctgacat caaagctctt atggaaggtg cgaatgcagc tcgcaaagac tacacttcag
     7141 acaaaatctc tgaaaacgaa gcttaccaat acgcagctgt tcggaacatc ctttatcgta
     7201 aaggctatgc aactgagatc ttggtaaact atgagccatc acttcaatac ttctcagaat
     7261 ggtggaaaca attggctggt gaatcagaag gaaaagacca aaaaggtatc tacccaactt
     7321 cagccaactt ctcaactgac ttgcactcac ttggtcaatt tatccaagaa ggaactcgta
     7381 tcatgtttga aacagttgtc cgtgttgaca aacctcgtaa aaacgtgctt attcctactt
     7441 tggaagaaga ccttgacgga cttggttacc ttcaaggaaa agacgttgac tttgtaaaca
     7501 aaaaagcaac tgacggtgtt cttcttgccc acacagatgg tgatgtacca aacatgtatg
     7561 tgactcttcc agagcaagac gctttcactc ttggttacac tatctacttc ttcgaattgg
     7621 caattgccct ttcaggttac ttgaatgcta tcaacccatt tgaccaacca ggtgttgaag
     7681 cttataaacg taacatgttt gcccttcttg gaaaaccagg atttgaagaa ttgagcaaag
     7741 aacttaacgc acgtctataa tagaagaaaa gagtggtttg cccactcttt ttactctctt
     7801 tatccataga aattggactc agccaagact tgtgatataa tatagaaagc aaaaaggcag
     7861 acgcctagat aataggagaa actatgtcaa aagatatccg cgtacgttac gcaccaagtc
     7921 caacagg
//
LOCUS       DBMVGT010000071         7871 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.071, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000071 DBMVGT010000000
VERSION     DBMVGT010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7871)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7871)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7871
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.071"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..420
                     /locus_tag="AC0DU4_001780"
     CDS             <1..420
                     /locus_tag="AC0DU4_001780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HIN4237704.1"
                     /translation="LLVLTDRKSRHQIIRLIPNKSADVVNQALKLILKQHKILSITAD
                     NGTEFNRLFDVFSEEHIYYAHPYASWERGTNENHNRLIRRWLPKGIKKMTPKEVAFIE
                     KWINNYPKKCLDYKSPREDFWMANLNLKFSVRNKSRN"
     gene            416..1090
                     /locus_tag="AC0DU4_001781"
     CDS             416..1090
                     /locus_tag="AC0DU4_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003025968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046873 - metal ion transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="VIT1/CCC1 transporter family protein"
                     /protein_id="HIN4237705.1"
                     /translation="MDSNFAGRLNILRAGVLDANDGIISIAGVVIGVASATSNIWIIF
                     LSGFAAILAGAFSMAGGEYVSVSTPKDTEEAAVSREKLLLDQDRELAKKSLYASYIQN
                     GEFKTSAQLLTNKIFLKNPLKALVEEKYGIEYEEFTNPWHAAISSFVAFFLRSLPPML
                     SVTIFPSDYRIPATVLIVGVALLLTGYTSARLGKAPTKTAMIRNLAIGLLTMGVTFLL
                     EQLFSI"
     gene            complement(1132..3120)
                     /locus_tag="AC0DU4_001782"
     CDS             complement(1132..3120)
                     /locus_tag="AC0DU4_001782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237706.1"
                     /translation="MFRLTNKLAVSNLIKNRKLYYPFALAVLLAVTVTYLFYSLTFNP
                     KIAEIRGGTTIQATLGFGMFVVTLASAIIVLYANSFVMKNRSKELGIYGMLGLEKRHL
                     ISMTFKELVVFGILTVGAGIGIGALFDKLIFAFLLKLMKLKVELVATFQMKVVITVLL
                     VFGLIFLGLMFLNALRIARMNALQLSREKASGEKKGRFLPLQTILGSISLGIGYYLAL
                     TVKDPLTALTTFFLAVLLVIFGTYLLFNAGITVFLQILKKNKKYYYQPNNLISVSNLI
                     FRMKKNAVGLATIAILSTMVLVTMSAATSIFNSAESFKKVLNPHDFGVSGQNVEKEDL
                     DKLLSQFASDKGYKIKEKEVLRYSNFGIANQEGTKLTIFEKGQNRVQPKTVFMVFDQK
                     DYENMTGQKLSLSGNEVGLFAKNDGLKGQKALTLNDHQFSVKEEFNKDFIVNHVPNKF
                     NILTTDYNYLVVPDLQAFLDQFPDSAIYNQFYGGMNVDASEEEQLKVAEEYENYLNQF
                     NAQLDTEGSYVYGSTLADASAQMSALFGGVFFIGIFLSIIFMVGTVLVIYYKQISEGY
                     EDRERFIILQKVGLDQKQIKQTINKQVLTVFFLPLLFAFLHLAFAYHMLSLILKVIGV
                     LDTTMMLIVTLSICAIFLIAYVLIFMITSRSYRKIVQM"
     gene            complement(3122..3880)
                     /locus_tag="AC0DU4_001783"
     CDS             complement(3122..3880)
                     /locus_tag="AC0DU4_001783"
                     /EC_number="7.6.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237707.1"
                     /translation="MTLLDVKHVQKIYKTRFQGNQVEALKDIHFTVEKGDYVAIMGES
                     GSGKSTLLNILAMLDKPSRGQVYLNGTDTATIKNSQASSFRREKLGFVFQDFNLLDTL
                     SVKDNILLPLVLSRRPITEMMKKLVVTAENLGINQLQEKYPYEISGGQKQRVAVARAI
                     ITEPEILLADEPTGALDSKSSAALLDVFDEINERGQTILMVTHSTAAASRAKRVLFIK
                     DGILYNQIYRGEKTERQMFQEISDTLTVMASEVN"
     gene            4308..4499
                     /locus_tag="AC0DU4_001784"
     CDS             4308..4499
                     /locus_tag="AC0DU4_001784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237708.1"
                     /translation="MKHKEHILIGLLYLLSPFIGQLLVEHTHFIGTEFTGTAYVICWL
                     SVVISIHHFSKNVLSQQQK"
     gene            complement(4853..5125)
                     /locus_tag="AC0DU4_001785"
     CDS             complement(4853..5125)
                     /locus_tag="AC0DU4_001785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HIN4237709.1"
                     /translation="MNSKFYKMRRNRMISGVLAGLSDKWNFDVTLVRFLFAIFTVANF
                     GLGVIIYIILASIMPTKEEIEAEMYGTGPRKRKEAQAIDDNEGWFW"
     gene            complement(5183..5632)
                     /locus_tag="AC0DU4_001786"
     CDS             complement(5183..5632)
                     /locus_tag="AC0DU4_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SprT family protein"
                     /protein_id="HIN4237710.1"
                     /translation="MKLTDYVKQVSLEDFGRPFIHHVQWNRRLRSTGGRFFPKDGHLD
                     FNPKVYQELGLDVFRKIVRHELCHYHLYFQGKGYQHKDRDFKELLKAVDGLRFVPSLP
                     NSNSKPIKLYRCQSCQQTYQRKRRIDTQRYRCGLCRGKLLLVNQPED"
     gene            complement(5619..7748)
                     /locus_tag="AC0DU4_001787"
     CDS             complement(5619..7748)
                     /locus_tag="AC0DU4_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005829 - cytosol [Evidence IEA];
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA];
                     GO_function: GO:0003729 - mRNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Tex family protein"
                     /protein_id="HIN4237711.1"
                     /translation="MDKKYEKISQDLGVTLKQIDTVLSLTAEGATIPFIARYRKDMTG
                     SLDEVAIKAIIDLDKSLTNLNDRKEAVLAKIQEQGKLTKELEEAILVAEKLADVEELY
                     LPYKEKRRTKATIAREAGLFPLARLILQNIVDLEKEAEKFVCEGFATGKEALTGAVDI
                     LVEALSEDVTLRSMTYQEVLRHSKLTSQAKDESLDEKQVFQIYYDFSETVGTMQGYRT
                     LALNRGEKLGVLKIGFEHATDRILAFFATRFKVKNAYIDEVVQQSVKKKVLPAIERRI
                     RTELTEKAEEGAIQLFSDNLRNLLLVAPLKGRVVLGFDPAFRTGAKLAVVDATGKMLT
                     TQVIYPVKPASARQIEEAKKDLADLIGQYGVEIIAIGNGTASRESEAFVAEVLKDFPE
                     VSYVIVNESGASVYSASELARQEFPDLTVEKRSAISIARRLQDPLAELVKIDPKSIGV
                     GQYQHDVSQKKLSESLDFVVDTVVNQVGVNVNTASPALLSHVAGLNKTISENIVKYRE
                     EEGKITSRSQIKKVPRLGAKAFEQAAGFLRIPESSNILDNTGVHPENYAAVKELFKCL
                     DIKDLNEEAQSKLKSLSVKEMAQELDLGPETLKDIIADLLKPGRDFRDSFDAPVLRQD
                     VLDIKDLVVGQKLEGVVRNVVDFGAFVDIGIHEDGLIHISHMSRKFIKHPSQVVAVGD
                     LVSVWVKKIDTEREKVNLSLLAPNETD"
BASE COUNT         2362 a         1654 c         1524 g         2331 t
ORIGIN      
        1 ttgcttgtct tgactgatcg aaagagtaga catcagatca tccgattgat tccaaataaa
       61 agtgctgatg tggtcaatca ggctctaaaa ctcatcttaa aacaacacaa gattctttcc
      121 atcacggcag ataatggaac ggaattcaat cgcttgtttg atgtattttc tgaggagcac
      181 atctattatg cgcaccccta tgcctcttgg gaaaggggaa ctaatgagaa tcacaacagg
      241 ctcattcgta gatggttacc taagggaatc aagaaaatga ctcccaaaga agtcgcattc
      301 atcgaaaagt ggattaacaa ctatcctaaa aaatgcttgg actacaagtc acccagagaa
      361 gacttctgga tggctaactt gaacttgaaa tttagcgtca gaaacaaatc acgaaattga
      421 ttcaaatttt gcaggtcgtt taaatatcct gcgtgcgggt gttcttgatg ctaacgatgg
      481 aattatttcc attgctggtg tggttatcgg agttgccagt gccacgagca atatctggat
      541 tatcttttta tcaggttttg cggctatctt agctggtgcc ttttcaatgg ctggtggaga
      601 atatgtatcc gtttcaactc caaaagatac cgaggaagct gccgtttcgc gagaaaaact
      661 cttgctagac caagataggg aactagccaa aaaatccctc tatgcttctt atatccaaaa
      721 tggagaattc aaaacttctg cccaactctt gactaataag atctttctta aaaatccact
      781 caaggctctg gtagaggaaa aatatgggat tgagtatgaa gaatttacca atccttggca
      841 cgctgccatt tctagcttcg ttgccttttt ccttagaagt ttgcctccaa tgctgtcagt
      901 gaccattttt ccaagtgatt accgcatccc tgctaccgtc cttattgtcg gtgtggccct
      961 tcttctcact ggttacacaa gtgctagact tggaaaagcc ccaaccaaaa cagctatgat
     1021 tcggaacctt gctattggtc tcttgaccat gggagttacc ttcctgctcg aacaactttt
     1081 cagcatttag aatacaagaa atacctcgat tttgaagtct aggtatcttt tttacatttg
     1141 cacaatcttg cgataacttc ttgaagtaat cataaaaatc agcacatagg cgatgaggaa
     1201 gatagcgcag atagacaagg tcacaatcaa catcatagtc gtatccagta caccaatcac
     1261 ttttaaaatc aggctaagca tatggtaggc aaaggctaga tgtaggaagg caaagagcaa
     1321 aggaaggaag aaaacagtta aaacctgttt gttgatggtt tgcttgattt gcttttggtc
     1381 caaaccgact ttctgcaaga taataaagcg ttcacggtct tcgtagcctt cagaaatttg
     1441 tttgtagtag atgaccagaa cagttccgac cataaagata atggatagga aaataccgat
     1501 aaagaagaca ccaccaaaga gggcactcat ctgagcacta gcatctgcta gagtgctacc
     1561 ataaacatag ctaccttctg tgtctaattg agcattaaat tgattgaggt agttttcata
     1621 ctcctcagcg accttgagtt gttcttcttc gctggcatct acattcatac caccgtaaaa
     1681 ctgattatag atagccgaat ctgggaattg atccaaaaag gcttgtaaat caggaacaac
     1741 aaggtaattg taatcagtag tcaagatatt aaacttattt ggaacatggt tgacaatgaa
     1801 atctttatta aattcttctt tgacagaaaa ttgatgatca tttagagtta gagctttctg
     1861 tcctttcagt ccgtcatttt tggcaaagag accgacctca tttcctgata gagacagttt
     1921 ttgaccagtc atattttcat aatctttttg gtcaaatacc atgaaaactg tttttggttg
     1981 gacacggttt tgtccttttt caaaaatagt taacttggtt ccttcttgat ttgcaatacc
     2041 aaagttactg taacgaagca cttctttctc tttaatctta taacctttgt cacttgcaaa
     2101 ctggctcaag agtttgtcca aatcttcttt ttcaacattt tgccctgaaa ccccaaaatc
     2161 atgaggattt agaacttttt taaaggattc tgcggaattg aaaatgcttg tcgctgctga
     2221 catggttacc aaaaccattg ttgacaaaat agcgatagtt gctagtccaa ctgcattttt
     2281 cttcatacgg aaaatcaagt tagaaacaga tatgagatta ttaggttggt aatagtattt
     2341 cttatttttc tttaagattt gaaggaaaac ggtaatccct gcattgaaca aaagataagt
     2401 accaaagata accagtaaaa cagctaggaa gaaggttgtt aaggctgtaa gaggatcttt
     2461 taccgtaagg gcaagataat atccaatccc taaacttatg gaaccaagaa tagtttggag
     2521 aggaaggaag cgaccttttt tctctccgct agctttctca cgtgagagct ggagggcatt
     2581 catacgggcg attcgaaggg cattcaggaa catgaggcct aggaaaatca aaccgaagac
     2641 aagaagtact gtaatgacaa ctttcatctg gaaggtagcg accagttcca ccttcaattt
     2701 catcagtttg agtaggaaag cgaaaatcaa cttgtcaaac aaggctccaa taccgatacc
     2761 cgctccaaca gttagaatcc caaataccac taactcctta aaggtcatac tgataagatg
     2821 acgcttctcc aagcccaaca tgccataaat tcctagttcc ttggaacggt tcttcatgac
     2881 aaaactattg gcatagagaa cgataatggc tgacgcaagg gtgacgacaa acataccaaa
     2941 tccaagtgta gcctgaatgg ttgttcctcc acggatttcc gcaatcttag gattgaaggt
     3001 tagagagtaa aagagatagg tgacagtgac tgccaagaga acagccagcg caaaaggata
     3061 gtagagtttg cggtttttaa tcaagttcga taccgctaac ttattggtta atcgaaacat
     3121 actaattcac ctcgcttgcc atgacagtca aggtatcaga gatttcttgg aacatctgac
     3181 gttctgtctt ctctccacgg tagatttgat tgtaaagaat gccgtctttg ataaagagta
     3241 cacgtttagc tctgctagct gctgctgttg agtgggttac catgagaatg gtttggccgc
     3301 gctcattgat ttcatcaaag acatcaagta aggctgcaga tgacttggag tcaagagctc
     3361 ctgtcggttc gtccgcaagg agaatttcag gttctgtgat gatggcgcgg gctactgcta
     3421 cacgctgttt ctgaccacca gaaatctcgt aagggtactt ctcttgtaat tggtttattc
     3481 ccagattctc agctgtcacc accaatttct tcatcatctc tgtaataggt cttcttgaca
     3541 agacaagcgg aagcaagata ttgtccttta cagatagagt atctagcaag ttaaagtctt
     3601 ggaagacaaa gcccaacttt tcacgacgga agctagaggc ctgtgaattt ttaatggttg
     3661 cggtgtcagt tccattcaag taaacctgac cacgacttgg tttatccagc atagctagaa
     3721 tattgagaag agttgattta ccagaaccag actcacccat gatggcaacg tagtcaccct
     3781 tttcgacggt aaagtgaata tccttgaggg cttctacttg gttgccctga aaacgtgttt
     3841 tataaatttt ttgaacgtgt tttacatcta aaagtgtcat gagaatctcc tttcttaata
     3901 tcccatcaaa tgaaatgtag cttgcatcat agtgcatccc agctgaacgc gctcaatttc
     3961 tttgtgactt ggttttctag ttttcttatg taagatttgt ttcatgatgt tactcctttg
     4021 ttctttatga gtctagttta catcaaaaaa agaccgcttg ccataaccta accttacaaa
     4081 agagacttta atcttacatt tttgtaagat tgggtgaaat ataagcaaaa ttacttagaa
     4141 aatgatttga tttcctattt ttaaagttgt aaaatataag tgtgaaaagg cttactttga
     4201 aaaggaggaa gcgggaacta acattttagt aaggttacct agataacata ccattcaatt
     4261 taacacttgc aagtcgttca acctataagg aaagaaggtg cgctttaatg aaacacaaag
     4321 aacatatact catcggactt ctctatctgc tctctccatt catcggtcag ctcttagttg
     4381 aacacacaca ctttatcggt acagaattta ccggcactgc ttatgttatt tgctggttat
     4441 cagttgttat cagcatccac catttttcca aaaatgtatt gtctcaacag caaaaataga
     4501 ttaaaaaact gcgtttaaat tactgctttt atagtaaaat gaaataagaa caggacaaat
     4561 cgatcaggac agtcaaatcg atttctaaca attttttaga agtataggtg tcctattcta
     4621 gttccaatcc actatagttt gtggatgaag ctggcgaaat attattaata ctattcaaaa
     4681 atcaaagtgc aaactatatc aacttcacat tgccgactaa attacagcct gcggctggct
     4741 tcctagtttg cactttgatt tttattgagt ataaaagtaa aaaagcttta aatcaagcag
     4801 tttagactat tgatttaaag ctttttgcgt attccaaatc ttttgtaaaa cctcaccaaa
     4861 accagccttc attatcgtca atggcttgag cttctttgcg tttacgtggg cctgttccgt
     4921 acatttctgc ttcgatttct tccttggttg gcatgataga agctaggatg atatagataa
     4981 tcaccccaag tccaaagttt gcgactgtaa aaatggcaaa cagaaaacgt acaagggtaa
     5041 catcaaagtt ccacttgtct gacagacctg ctaaaactcc tgaaatcatg cgatttcgtc
     5101 tcattttata aaacttactg ttcatgatat ttcctctttc tgctaggtta gactagtata
     5161 tcacggatag gctcggcttt catcagtcct caggctgatt tactaatagc aactttcctc
     5221 gacaaagtcc acagcgatag cgttgggtat caatcctacg cttacgctga taagtttgct
     5281 ggcaggattg gcaacgatag agcttgattg gcttggagtt actattgggc aaggatggta
     5341 caaaccgtaa tccatccact gctttcaaca gttccttaaa atcccgatcc ttgtgttgat
     5401 agcctttccc ttgaaaatag aggtgataat gacagagttc atgtcggaca attttcctaa
     5461 aaacgtccaa ccccagttcc tgataaacct tgggattaaa atccaaatgc ccatctttgg
     5521 ggaaaaatcg cccacctgtc gaacgtagac gcctattcca ctggacatga tggataaaag
     5581 gtctgccgaa gtcttctagt gaaacctgct tgacgtaatc agtcagtttc atttggagct
     5641 aggagagaca gattaacttt ttcacgttca gtatcaattt tcttaaccca aacgctcacc
     5701 aaatctccaa ctgccaccac ttgactaggg tgtttgataa acttgcgact catatgggaa
     5761 atatggatga gaccgtcctc atgaattccg atatcaacaa aagcaccgaa atcaacaaca
     5821 ttacgcacca ctccttctag cttttgtcca accactaagt ccttgatatc taggacatct
     5881 tgacggagaa ctggagcatc aaaggaatca cggaaatctc gacctggttt gagaagatct
     5941 gcaatgatat ctttaagagt ttctggacca aggtctaact cttgcgccat ttccttgact
     6001 gaaagcgact tgagtttact ttgggcctct tcattcagat ccttaatgtc caagcatttg
     6061 aagagttcct taacggcagc gtaattttct gggtgaactc ctgtattatc aaggatattg
     6121 ctactttcag ggatacggag gaaaccagca gcctgttcaa aagccttggc ccccaaacga
     6181 ggaactttct tgatttggga gcgtgaagtg atttttccct cttcctcacg gtatttgacg
     6241 atattttcag aaatggtttt attgagtcca gctacgtgtg aaagaagagc tgggctagct
     6301 gtattgacat tgacaccaac ttggttaacc actgtatcga caacaaagtc cagactctca
     6361 gatagtttct tctgactgac atcgtgttgg tattgaccga caccaattga cttaggatcg
     6421 attttgacca attccgcaag aggatcttgc aaacgacggg cgatagaaat ggcagagcgt
     6481 ttttcaacgg tcaagtctgg aaactcctga cgagcaagtt cgctggcaga atagacagaa
     6541 gcaccacttt cattaacgat aacatagctg acttcaggga aatctttcag aacttccgct
     6601 acaaaagctt cactttcacg actggccgtt ccatttccaa tggcaataat ctctacaccg
     6661 tattgaccaa ttaaatctgc taaatctttc ttggcttctt cgatttgacg agctgatgct
     6721 ggtttaacag gataaataac ctgagttgtc agcatttttc ctgttgcatc cacgacagct
     6781 agcttggcac ctgtacgaaa ggctgggtca aacccaagaa ccacgcgccc tttcagtgga
     6841 gcaaccaaga ggagattgcg cagattgtca gaaaaaagtt ggatagctcc ctcttcagct
     6901 ttctcagtta attctgtccg aatacgacgc tcaatagcag gcaagacctt tttcttaacg
     6961 gattgctgaa caacttcatc aatataagca tttttcacct tgaaacgagt agcaaagaag
     7021 gcaagaatac ggtccgtcgc atgttcaaaa ccgatcttca agacaccaag tttctcccca
     7081 cgattgagag ccaaggtacg atagccttgc atagttccaa ctgtctctga aaaatcataa
     7141 taaatctgaa aaacctgctt ttcatcaaga ctttcatcct tggcttgaga agtgagttta
     7201 gagtgtctca gcacttcctg ataagtcata gaacgcaagg tcacatcttc cgataaggct
     7261 tcgaccaaaa tatcaactgc accggtcaag gcttccttgc cagtcgcaaa tccttcacag
     7321 acgaactttt cagcttcttt ctctaagtca actatattct gcaaaatcaa gcgagcaaga
     7381 ggaaagagtc cagcttcacg ggcaatggtt gccttggtac gacgcttttc cttataagga
     7441 agatagagtt cttcaacgtc tgctaatttt tcggcaacta agatagcttc ttccaattcc
     7501 ttggtcaact taccttgttc ttgaatctta gctaagacag cttccttacg gtcattgaga
     7561 tttgtcagac ttttatccaa atcaataata gccttaatcg ccacctcatc cagactacca
     7621 gtcatgtcct tgcgataacg cgcgataaag ggaatagtcg ccccttcagc tgtcaaactt
     7681 agaacggtat caatttgctt taacgtcact cccaaatcct gagagatttt ttcatatttt
     7741 ttatccataa atctattata ccacaagctg gaaggctttc tccaatcctt ttcatactca
     7801 ataaaaatca aaaagcaaac taggaagcta gccgtaggct gctcaaaata ctgttttgag
     7861 gttgtggata a
//
LOCUS       DBMVGT010000072         7867 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.072, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000072 DBMVGT010000000
VERSION     DBMVGT010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7867)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7867)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7867
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.072"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            143..2125
                     /locus_tag="AC0DU4_001788"
     CDS             143..2125
                     /locus_tag="AC0DU4_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4237712.1"
                     /translation="MKSSRLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETDP
                     DNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKDA
                     KWYTSEGEEYAAVKAQDFVTGLKYAADKKSDALYLVQESIKGLDAYVKGEIKDFSQVG
                     IKALDEQTVQYTLNKPESFWNSKTTMGVLAPVNEEFLNSKGDDFAKATDPSSLLYNGP
                     YLLKSIVTKSSVEFAKNPNYWDKDNVHIDKVKLSFWDGQDTSKPAENFKDGSLTAARL
                     YPTSASFAELEKSMKDNIVYTQQDSITYLVGTNIDRQSYKYTSKTSEEQKTSTKKALL
                     NKDFRQAIAFGFDRTAYASQLNGQTGASKILRNIFVPPTFVQADGKNFGDMVKEKLVT
                     YGDEWKDVNLADSQDGLYNPEKAKAEFAKAKSALQAEGVTFPIHLDMPVDQTATTKVQ
                     RVQSMKQSLEATLGADNVVIDIQQLQKDEVNNITYFAENAAGEDWDLSDNVGWGPDFA
                     DPSTYLDIIKPSVGESTKTYLGFDSGEDNVAAKKVGLYDYEKLVTEAGDETTDVAKRY
                     DKYAAAQAWLTDSALIIPTTSRTGRPILSKMVPFTIPFALSGNKGTSEPVLYKYLELQ
                     DKAVTVDEYQKAQEKWMKEKEESNKKAQEDLAKHVK"
     gene            2426..7729
                     /locus_tag="AC0DU4_001789"
     CDS             2426..7729
                     /locus_tag="AC0DU4_001789"
                     /EC_number="3.2.1.97"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001032503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033926 -
                     endo-alpha-N-acetylgalactosaminidase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SpGH101 family
                     endo-alpha-N-acetylgalactosaminidase"
                     /protein_id="HIN4237713.1"
                     /translation="MNKGLFEKRCKYSIRKFSLGVASVMIGAAFFGTSPVLADSVQSG
                     STANLPADLATALATAKENDGRDFEAPKVGEDQGSPEVTDGPKTEEELLALEKEKPAE
                     EKPKEDKPAAAKPETPKTVTPEWQTVEKKEQKGTVTIREEKGVRYNQLSSTAQNDNAG
                     KPALFEKKGLTVDANGNATVDLTFKDDSEKGKSRFGVFLKFKDTNNNVFVGYDKDGWF
                     WEYKSPTTSTWYRGSRVAAPETGSTNRLSITLKSDGQLNASNNDVNLFDTVTLPAAVN
                     DHLKNEKKILLKAGSYGNDRTVVSVKTDNQEGVKADDTPAQKETGPVVDDSKVTYDTI
                     QSKVLKAVIDQAFPRVKEYSLNGHTLPGQVQQFNQVFINNHRITPEVTYKKINETTAE
                     YLMKLRDDAHLINAEMTVRLQVVDNQLHFDVTKIVNHNQVTPGQKIDDERKLLSSISF
                     LGNALVSVSSDQTGAKFDGATMSNNTHVSGDDHIDVTNPMKDLAKGYMYGFVSTDKLA
                     AGVWSNSQNSYGGGSNDWTRLTAYKETVGNANYVGIHSSEWQWEKAYKGIVFPEYTKE
                     LPRAKVVITEDANADKKVDWQDGAIAYRSIMNNPQGWEKVKDITAYRIAMNFGSQAQN
                     PFLMTLDGIKKINLHTDGLGQGVLLKGYGSEGHDSGHLNYADIGKRIGGVEDFKTLIE
                     KAKKYGAHLGIHVNASETYPESKYFNEKILRKNPDGSYSYGWNWLDQGINIDAAYDLA
                     HGRLARWEDLKKKLGDGLDFIYVDVWGNGQSGDNGAWATHVLAKEINKQGWRFAIEWG
                     HGGEYDSTFHHWAADLTYGGYTNKGINSAITRFIRNHQKDAWVGDYRSYGGAANYPLL
                     GGYSMKDFEGWQGRSDYNGYVTNLFAHDVMTKYFQHFTVSKWENGTPVTMTDNGSTYK
                     WTPEMRVELVDADNNKVVVTRKSNDVNSPQYRERTVTLNGRVIQDGSAYLTPWNWDAN
                     GKKLSTEKEKMYYFNTQAGTTTWTLPSDWAKSKVYLYKLTDQGKTEEQELTVKDGKIT
                     LDLLANQPYVLYRSKQTNPEMSWSEGMHIYDQGFNSGTLKHWTISGDASKAEIVKSQG
                     ANDMLRIQGNKEKVSLTQKLTGLKPNTKYAVYVGVDNRSNAKASITVNTGEKEVTTYT
                     NKSLALNYVKAYAHNTRRNNATVDDTSYFQNMYAFFTTGSDVSNVTLTLSREAGDQAT
                     YFDEIRTFENNSSMYGDKHDTGKGTFKQDFENVAQGIFPFVVGGVEGVEDNRTHLSEK
                     HDPYTQRGWNGKKVDDVIEGNWSLKTNGLVSRRNLVYQTIPQNFRFEAGKTYRVTFEY
                     EAGSDNTYAFVVGKGEFQSGRRGTQASNLEMHELPNTWTDSKKAKKVTFLVTGAETGD
                     TWVGIYSTGNASNTRSDSGGNANFRGYNDFMMDNLQIEEITLTGKMLTENALKNYLPT
                     VAMTNYTKESMDALKEAVFNLSQADDDISVEEARAEIAKIEALKNALVQKKTALVAED
                     FASLTAPAQAQEGLANAFDGNLSSLWHTSWGGGDVGKPATMVLKEATEITGLRYVPRG
                     SGSNGNLRDVKLVVTDESGKEHTFTATDWPDNNKPKDIDFGKTIKAKKIVLTGTKTYG
                     DGGDKYQSAAELIFTRPQVAETPLDLSGYEAALAKAQKLTDKDNQEEVASVQASMKYA
                     TDNHLLTERMVEYFADYLNQLKDSATKPDAPTVEKPEFKLSSLVSNQGKTPDYKQEID
                     RPETPEQILPATGESQSDTALFLASVSLALSALFVVKTKKD"
BASE COUNT         2585 a         1493 c         1727 g         2062 t
ORIGIN      
        1 tatagttgag ggatttttaa atgatattca tattttttgc aaagatgttg tttgaaaaat
       61 aattttcaaa aattctgaaa attctgttga caactttctg aaaagagtct ataatggaga
      121 gaaagtttta aaggagaaaa tgatgaaaag ttcaagacta tttgcccttg cgggcgtgac
      181 attattggcg gcgactactt tagctgcatg ctctggatca ggttcaagca ctaaaggtga
      241 gaagacattc tcatacattt atgagacaga ccctgataac ctcaactatt tgacaactgc
      301 taaggctgcg acagcaaata ttaccagtaa cgtggttgat ggtttgctag aaaatgatcg
      361 ctacgggaac tttgtgccgt ctatggctga ggattggtct gtatccaagg atggattgac
      421 ttacacttat actatccgta aggatgcaaa atggtatact tctgaaggtg aagaatacgc
      481 ggcagtcaaa gctcaagact ttgtaacagg actaaaatat gctgctgata aaaaatcaga
      541 tgctctttac cttgttcaag aatcaatcaa agggttggat gcctatgtaa aaggggaaat
      601 caaagatttc tcacaagtag gaattaaggc tctggatgaa cagacagttc agtacacttt
      661 gaacaaacca gaaagcttct ggaattctaa gacaaccatg ggtgtgcttg cgccagttaa
      721 tgaagagttt ttgaattcaa aaggggatga ttttgccaaa gctacggatc caagtagtct
      781 cttgtataac ggtccttatt tgttgaaatc cattgtgacc aaatcttctg ttgaatttgc
      841 gaaaaatccg aactactggg ataaggacaa tgtgcatatt gacaaagtta aattgtcatt
      901 ctgggatggt caagatacca gcaaacctgc agaaaacttt aaagatggta gccttacagc
      961 agctcgtctc tatccaacaa gtgcaagttt cgcagagctt gagaagagta tgaaggacaa
     1021 tattgtctat actcaacaag actctattac gtatctagtt ggtacaaata ttgaccgtca
     1081 gtcctataaa tatacatcta agaccagtga agaacaaaaa acatctacga aaaaggctct
     1141 cttaaacaag gatttccgtc aggctattgc atttggattt gaccgtacag cctatgcctc
     1201 tcagttgaat ggacaaactg gagcaagcaa aatcttacgt aatatctttg ttccaccaac
     1261 atttgttcaa gcagatggta aaaactttgg cgatatggtc aaagagaaat tggtcactta
     1321 tggggatgaa tggaaggatg ttaatcttgc agattctcag gatggtcttt acaatccaga
     1381 aaaagccaag gctgaatttg ctaaagctaa atcagcttta caagcagaag gtgtgacttt
     1441 cccaattcat ttggatatgc cagttgacca gacagcaact acaaaagttc agcgcgtcca
     1501 atctatgaaa caatccttgg aagcaacttt aggagcggat aatgtagtca ttgatattca
     1561 acaactacaa aaagacgaag taaacaatat tacatatttt gctgaaaatg ctgctggtga
     1621 agactgggat ttatcagata atgtcggttg gggtccagac tttgccgatc catcaaccta
     1681 ccttgatatc atcaaaccat ctgtaggaga aagtactaaa acatatttag ggtttgactc
     1741 aggggaagat aatgtagctg ctaaaaaagt aggtctatat gactacgaaa aattggttac
     1801 tgaggctggt gatgagacta cagatgttgc taaacgctat gataaatacg ctgcagccca
     1861 agcttggttg acagatagtg ctttgattat tccaactaca tctcgtacag ggcgtccaat
     1921 cttgtctaag atggtaccat ttacaatacc atttgcattg tcaggaaata aaggcacaag
     1981 tgaaccagtc ttgtataaat acttggaact tcaagacaag gcagtcactg tagatgaata
     2041 ccaaaaagct caggaaaaat ggatgaaaga aaaagaagag tctaataaaa aggctcaaga
     2101 agatctcgca aaacatgtga aataactgtt gcaaaatata agaaaggatt tagtatttcc
     2161 cttgaatgct gaatcctttt ttacatttgt aaagaaagat tctaaatgta ctgaccccca
     2221 aaagttggag cctctttttg tcagaataga gaaaattttt gttaatttta cttgtttcct
     2281 attgctttct cagctattat ttgttatatt aaaagcataa ttatttttta tttatcaggg
     2341 ttaagcattg cactttcaga ggaaggagta ttttttaaaa aggaaatgta aacgcttgct
     2401 aaaaaatgaa aggatttaga agtttatgaa taaaggatta tttgaaaaac gttgtaaata
     2461 tagtattcgg aaattttcat taggtgttgc ttctgttatg attggagctg cattctttgg
     2521 gacaagtccg gttcttgcag atagcgtgca gtctggttcc acggcgaact taccagctga
     2581 tttagctact gctcttgcaa cagcaaaaga gaatgatgga cgtgattttg aagcgcctaa
     2641 ggtgggagaa gaccaaggtt ctccagaagt tacagatgga cctaagacag aagaagaact
     2701 attagcactt gaaaaagaaa aaccggctga agaaaaacca aaagaggata aacctgcagc
     2761 tgctaaacct gaaacaccta agacggtaac ccctgaatgg caaacggtag agaaaaaaga
     2821 acaaaaggga acagtcacta tccgagaaga aaaaggtgtc cgctacaacc aactatcctc
     2881 aactgctcaa aatgataacg caggaaaacc agccctgttt gaaaagaagg gcttgaccgt
     2941 tgatgccaat ggaaatgcaa ctgttgattt aaccttcaaa gatgattctg aaaagggcaa
     3001 atcacgcttt ggtgtcttcc tgaaatttaa agataccaat aataatgttt ttgtcggtta
     3061 tgacaaggat ggctggttct gggagtataa atctccaaca actagcactt ggtatagagg
     3121 tagtcgtgtt gctgctcctg aaacaggatc aacaaaccgt ctctctatca ctctcaagtc
     3181 agacggtcag ctaaatgcca gcaataacga tgtcaatctc tttgacacag tgactctacc
     3241 agctgcggtc aatgaccatc ttaaaaatga gaagaagatc cttctcaagg cgggctctta
     3301 tggcaatgac cgtacggttg tcagcgttaa aacagacaat caagaaggcg taaaagcgga
     3361 tgatactcct gcccagaaag aaacaggtcc ggttgttgac gatagcaagg tgacttatga
     3421 tacgatccag tctaaggtac ttaaggcagt aattgaccaa gccttccctc gtgtcaagga
     3481 atacagcttg aacgggcata ctttgccagg acaggtgcaa cagttcaacc aagtctttat
     3541 caataaccac cgaatcaccc ctgaagtcac ttataagaaa atcaatgaga caacagcaga
     3601 gtacttgatg aagcttcgcg atgatgctca cttaatcaat gcggaaatga cagtacgcct
     3661 gcaagttgtg gacaatcaat tgcactttga tgtgaccaag attgtcaacc acaatcaagt
     3721 cactccaggt caaaagattg atgacgaaag aaaactactt tcttctatta gtttcctcgg
     3781 caatgcttta gtctctgttt ctagtgatca aactggtgct aagtttgatg gggcaaccat
     3841 gtcaaacaat acgcatgtca gcggagatga tcatatcgat gtaaccaatc caatgaaaga
     3901 cctagccaag ggttacatgt atggatttgt ttctacagat aagcttgctg ctggtgtttg
     3961 gagtaactct caaaacagct atggtggtgg ttcgaatgac tggactcgtt tgacagctta
     4021 taaagaaaca gtcggaaatg ccaactatgt aggaatccac agctctgaat ggcaatggga
     4081 aaaagcttat aagggcattg ttttcccaga atacacgaag gaacttccaa gggctaaggt
     4141 tgttatcact gaagatgcca atgcagacaa gaaagtcgat tggcaggatg gtgccattgc
     4201 ttatcgtagc attatgaaca accctcaagg ttgggaaaaa gttaaggata tcacagctta
     4261 ccgtatcgcg atgaactttg gttctcaagc acaaaaccca ttccttatga ccttggatgg
     4321 tatcaagaaa atcaatctcc acacagatgg tcttgggcaa ggtgttctcc ttaaaggata
     4381 tggtagcgaa ggccatgact ctggtcactt gaactatgct gatattggta agcgtatcgg
     4441 tggtgtcgaa gacttcaaga ccctgattga gaaggctaag aaatatggag ctcatctagg
     4501 tatccacgtt aacgcttcag aaacttatcc tgagtctaaa tacttcaatg aaaaaattct
     4561 ccgtaagaat ccagatggaa gctatagcta tggttggaac tggctagatc aaggtatcaa
     4621 cattgatgct gcctatgacc tagctcatgg tcgtttggca cgttgggaag atttgaagaa
     4681 aaaacttggt gacggtctcg actttatcta tgtggacgtt tggggtaatg gtcaatcagg
     4741 tgataacggt gcctgggcta cccacgttct tgctaaagaa attaacaaac aaggctggcg
     4801 ctttgcgatc gagtggggcc atggtggtga gtacgactct accttccatc actgggcagc
     4861 tgacttgacc tacggtggct acaccaataa aggtatcaac agtgccatca cccgctttat
     4921 ccgtaaccac caaaaagatg cttgggtagg ggactacaga agttatggtg gtgcagccaa
     4981 ctatccactg ctaggtggct acagcatgaa agactttgaa ggctggcaag gaagaagtga
     5041 ctacaatggc tatgtgacta acctctttgc tcatgacgtc atgactaagt acttccaaca
     5101 cttcactgta agtaaatggg aaaatggtac accggtgact atgaccgata acggtagcac
     5161 ctataaatgg actccagaaa tgcgagtgga gttggtagat gctgacaata ataaagtagt
     5221 tgtaactcgt aagtcaaatg atgtcaatag cccacaatat cgcgaacgta cagtaacgct
     5281 caacggacgt gtcatccaag atggttcagc ttacttgact ccttggaact gggatgcaaa
     5341 tggtaagaaa ctttctactg agaaggaaaa gatgtactac ttcaatacgc aggccggtac
     5401 aacaacttgg acccttccaa gcgattgggc aaagagcaag gtttaccttt acaagctaac
     5461 tgaccaaggt aagacagaag agcaagaact aactgtaaaa gatggtaaaa ttaccctaga
     5521 tcttctagca aatcaaccat acgtacttta ccgttcaaaa caaaccaatc ctgaaatgtc
     5581 atggagtgaa ggcatgcaca tctatgacca aggatttaat agtggaacct tgaaacactg
     5641 gaccatttca ggcgatgctt ctaaggcaga aattgtcaag tctcaagggg caaacgatat
     5701 gcttcgtatt caaggaaaca aagaaaaagt tagtctcact cagaaattaa ctggcttgaa
     5761 accaaatacc aagtatgccg tttatgtcgg tgtcgataac cgtagtaatg ccaaggcaag
     5821 tatcactgtg aatactggtg aaaaagaagt gactacttat accaataagt ctctcgccct
     5881 caactatgta aaagcctacg cccacaatac acgtcgtaac aatgctacag ttgacgatac
     5941 aagttacttc caaaacatgt acgccttctt tacaactgga tcggacgtct caaatgttac
     6001 tctgacattg agtcgtgaag ctggtgatca agcaacttac tttgatgaaa ttcgtacctt
     6061 tgaaaacaat tcaagcatgt acggagacaa gcatgataca ggtaaaggca ccttcaagca
     6121 agactttgaa aatgttgctc agggtatctt cccatttgta gtgggtggtg ttgaaggtgt
     6181 tgaagataac cgcactcact tgtctgaaaa acacgatcca tatacacaac gtggttggaa
     6241 tggtaagaaa gtcgatgatg ttatcgaagg aaattggtca ctcaagacaa atggactagt
     6301 gagccgtcgt aacttggttt accaaactat tccgcaaaac ttccgttttg aagcaggtaa
     6361 gacctaccgt gtaacctttg aatacgaagc aggttcagac aatacctatg cttttgtagt
     6421 cggtaaggga gaattccagt caggtcgtcg tggtactcaa gcaagcaact tggaaatgca
     6481 tgaattgcca aatacttgga cagattctaa gaaagccaag aaggtaacct tccttgtgac
     6541 aggtgcagaa acaggggata cttgggtagg tatctactca actggcaatg caagtaatac
     6601 tcgtagtgat tctggtggaa atgccaactt ccgtggttat aacgacttca tgatggataa
     6661 tcttcaaatc gaagaaatta ccctaacagg taagatgttg acagaaaatg ctctgaagaa
     6721 ctacttgcca acggttgcca tgactaacta caccaaagag tctatggatg ctttgaaaga
     6781 ggcggtcttt aacctcagtc aggccgatga tgatatcagt gtggaagaag cgcgtgcaga
     6841 gattgccaag attgaagcct tgaagaatgc tttggttcag aagaaaacgg ctttggtagc
     6901 agaagacttt gcaagtctta cagctcctgc tcaggctcaa gaaggtcttg caaatgcctt
     6961 tgatggaaac ttatctagtt tatggcatac atcatggggc ggaggagatg taggcaagcc
     7021 tgcaaccatg gtcttgaaag aagcaactga aatcactgga cttcgttatg ttccacgtgg
     7081 atcaggttca aatggtaact tgcgtgatgt gaaacttgtt gtgacagatg agtctggcaa
     7141 ggagcatacc tttactgcaa ctgattggcc agataacaat aagccaaaag acattgattt
     7201 tggtaagaca attaaggcta agaaaattgt ccttacaggt actaagactt acggagatgg
     7261 tggcgataaa taccaatctg cagcggaact tatctttact cgtccacagg tagcagaaac
     7321 acctcttgac ttgtcaggct atgaagcagc tttggctaag gctcagaaat taacagacaa
     7381 agacaatcaa gaggaagtag ctagcgttca ggcaagcatg aaatatgcga cggataacca
     7441 tctcttgacg gaaagaatgg tggaatactt tgcagattat ctcaaccaat taaaagattc
     7501 tgctacgaaa ccagatgctc caactgtaga gaaacctgag tttaaactta gctctttagt
     7561 ttccaatcaa ggtaagacgc cagattataa gcaagaaata gatagaccag aaacacctga
     7621 acaaatcttg ccagcaacag gtgagagtca atctgacaca gccctcttcc tagcaagtgt
     7681 tagtctagcc ctatctgctc tctttgtagt aaaaacgaag aaagactagt atttagtaaa
     7741 acctcttaac aagattacgg aagcagtctc tatcttttcc aatgaggttt atagtacaga
     7801 aaaagcctga gaagatgtct tctcaggctt ttgttaagca cataaataca atagtgctat
     7861 gacaaaa
//
LOCUS       DBMVGT010000073         7670 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.073, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000073 DBMVGT010000000
VERSION     DBMVGT010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7670)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7670)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7670
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.073"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..866)
                     /locus_tag="AC0DU4_001790"
                     /pseudo
     CDS             complement(1..866)
                     /locus_tag="AC0DU4_001790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
     gene            1075..2844
                     /locus_tag="AC0DU4_001791"
     CDS             1075..2844
                     /locus_tag="AC0DU4_001791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannitol-specific transporter subunit IIBC"
                     /protein_id="HIN4237714.1"
                     /translation="MEEKVSLKVRVQKLGTSLSNMVMPNIGAFIAWGVLTALFIADGY
                     LPNEQLATVVGPMLTYLLPILIGYTGGYMIHGQRGAVVGAIATVGAITGSSVPMFIGA
                     MVMGPLGGWTIKKFDEKFQEKIRPGFEMLVNNFSAGLVGFALLLLAFYAIGPVVSTLT
                     VAVGNGVEAIVNARLLPMANIIIEPAKVLFLNNALNHGIFTPLGVEQVAQAGKSILFL
                     LEANPGPGLGILLAYAVFGKGSAKSSSWGAMVIHFFGGIHEIYFPYVMMKPTLFLAAM
                     AGGISGTFTFQLLDAGLKSPASPGSIIAIMATAPKGVWPHLNVLLGVLVAAVVSFLVA
                     ALILHADKSTEDSLEAAQAATQAAKAQSKGQLVSTSVDAVVSTDSVEKIIFACDAGMG
                     SSAMGASILRDKVKKAGLEIPVSNQAISNLLDTPKTLIVTQEELTPRAKDKSPSAIHV
                     SVDNFLASPRYDEIVASLTGAFPIAEIEGDIPTSAPVDSQEIDLNHIDAVVVAYGKAQ
                     GTATMGCETIRAIFRNKNIRIPVSTAKISELGEFNSKNIMIVTTISLQAEVQQAAPNS
                     QFLIVDSLVTTPEYDKMAARMYK"
     gene            2868..4823
                     /locus_tag="AC0DU4_001792"
     CDS             2868..4823
                     /locus_tag="AC0DU4_001792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HIN4237715.1"
                     /translation="MLLTKREEQLLKAFLHVGKLSMQDMTEILQVSSRTIYRTLSDLT
                     DSMEQYGIEITKHGKYYILTGELDDLPTELEVLVEYSPQERQELITYRLLTESGFVTN
                     EALQECTKVSNVTIIQDISDIDKRLLDFDLKIERQKGYRISGDSVGKRRFLAILLTNC
                     ISVADFSTGNFGSFDILEADRTRLASQIVNKQLSGFPDMDARMKMFFAILLSLIGQEQ
                     NIENSPNTSKQALEISQKIFQAYSKQTAQFYSIQEIIYFASILDELIIKRQDNPLFTE
                     KFDGEFFYNISNLIDTVSMYTKIDFFKDKVLFNFLFHHIRLSLGVPILFQGENLPESI
                     QILVERNKFLYTVISLLVNDIFPKYLHTEYEYGMIALHFISSLGRSPEIYPVRVLLLT
                     DERRVTRDLLVSKIKSVAPFVELIDIQSLVDYHSIDLSQYDYILSTKPLTNQEIDVIS
                     SFPTVKELLELQERLQYVQAHRTIVARDAIAPEKSYDLQDYLISSSQLLSQFELVQLE
                     NNQSFEHTVEQIIQYQKNVSDRDYLTRKLLSHFQNSPMAIPNTGLVLLHSQSSKVTTN
                     SFTMFELKLPISALSMKREEEEVKRCLLMLMSKEASEEARDLMTAISQSIIENHLYTE
                     IYKTGNQSIIYQMLNTIFNEKIKKLEN"
     gene            4825..5262
                     /locus_tag="AC0DU4_001793"
     CDS             4825..5262
                     /locus_tag="AC0DU4_001793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HIN4237716.1"
                     /translation="MKLEKHLIKLNKQFSNKEEAICYCGQVLYEGGYVNEDYIEAMIE
                     RDKELSVYMGNFIAIPHGTDAAKKDVLKSGITVVQVPRGVDFGNVSNPQVATVLFGIA
                     GIGNEHLEIIQKISIFCADVDNVLKLADAQSKEEVLRLFDAVE"
     gene            5324..6460
                     /locus_tag="AC0DU4_001794"
     CDS             5324..6460
                     /locus_tag="AC0DU4_001794"
                     /EC_number="1.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannitol-1-phosphate 5-dehydrogenase"
                     /protein_id="HIN4237717.1"
                     /translation="MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEK
                     GKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELL
                     AKGIEARRVAGNTQALDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
                     DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVN
                     SGHATSAYIGAHYGAKTILEALQNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHK
                     VIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSLSYKNLLKTVGYAFD
                     YRDVNDEESIRLGELLAKQSVKDVVIQVTGLDDQELIEQIVEYI"
     gene            7246..>7670
                     /locus_tag="AC0DU4_001795"
     CDS             7246..>7670
                     /locus_tag="AC0DU4_001795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397742.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor family protein"
                     /protein_id="HIN4237718.1"
                     /translation="MSVSFENKETNRGVLTFTISQDQIKPELDRVFKSVKKSLNVPGF
                     RKGHLPRPIFDKKFGEESLYQDVMNALLPNAYEAAVKEAGLEVVAQPKIDVTSMEKGQ
                     DWVIAAEVVTKPEVKLGDYKNLEVSVDVEKEVTDADVEER"
BASE COUNT         2338 a         1300 c         1512 g         2520 t
ORIGIN      
        1 ttccattgtt ttagagcctt caaattggcc ttgaatgaga ttctctgctt tcttaccaac
       61 gtctccttta tgagaagaat attttcgttt ctgtcgcatt ttagcttgta aattgagtac
      121 ttttatcaag ccttgaactc ttttatgatt taccagataa gcacgatttc ttagttctaa
      181 ataaatccga cgataagcat aatttccttt gtgttcgata aagatggatt gaatttcagc
      241 tttaagctct tggtccttat ctgttttgtc tagctgtttc aagtgatagt agtaggtcca
      301 acgagctagt ttaatggatt ttagaagaag aactaacgaa aactcagtca ttaattcttg
      361 aacaatttct gtccttcttc tttctctttt tcctccttca atcggagttc tcttaacttt
      421 tttaggatgg cattctccgc tctcaggtac tcattttctg cttgaagata ttctaattct
      481 gtcctctctt caggtctcgt ttttggctta cgtcccattt taggtactct ccctcttgtt
      541 ttctcaacaa tagtataccc gtttttcctg tattgtgcta gccagttaag aagtatcgta
      601 cgacttggga ggccgtattc aagagaaact ctatctttag tccagccttc atgtcagact
      661 ttattaatca tttcttgttt taaatcagga gaatagtaac gatttttccc ttttttgacg
      721 aactctattc cgtaacgatc aatcaattta atcatgtacc taagattaga attatttatc
      781 ccaaatttat ttgaaagctt ctctaagcta tatccttgct ttctaagttc atagatctga
      841 actttatcat cataagttaa tttcataata aaaacacccc aaaagttaga ttttttctgt
      901 ctaacttttg gggtgtagtt catgtacacc tgatatgatg cgttttataa tttttaagcc
      961 tttttgccca gcctcgtcaa aagtaatgtt ttgacacaaa atctgtgaca aaactttagt
     1021 tttaaaggtt tttaactttg tatatactag ttttaagaaa aggaggatga tctaatggaa
     1081 gaaaaagtat cattgaaggt cagggttcaa aaactaggga catcgctttc aaatatggtt
     1141 atgcccaata ttggagcatt tattgcttgg ggagtattga ctgccctctt tatcgctgat
     1201 ggctatctgc caaatgaaca gttagctact gttgttggtc ctatgttaac gtatttattg
     1261 ccaatcctga ttggttacac aggtggatat atgatccatg gccaacgtgg tgccgttgta
     1321 ggagctattg ctactgttgg tgcaatcaca ggttctagtg ttcctatgtt tatcggagct
     1381 atggtaatgg gcccactggg aggatggact atcaagaaat ttgatgagaa gttccaggaa
     1441 aaaattcgtc ccggatttga aatgttagtt aataacttct cagctggtct cgttggtttt
     1501 gcattattgc ttttggcttt ctacgcaatc ggtccagtcg tatcgactct tactgtagct
     1561 gttgggaatg gtgttgaggc tattgtcaat gctcgcctcc ttcctatggc taatattatc
     1621 atcgaaccgg ctaaagtcct ttttctcaat aatgccctca atcatggcat ttttactcct
     1681 ctgggagtag aacaggtagc tcaagctggt aagtcaattc tcttcctatt ggaagctaat
     1741 cctggaccag gcctgggaat tctattagct tatgctgtat tcggtaaagg ttctgctaaa
     1801 tcttcttctt ggggggcaat ggttattcat ttcttcggag ggattcatga aatttacttt
     1861 ccttatgtta tgatgaagcc tactctattt ttagctgcta tggcaggagg tatctctgga
     1921 acttttactt ttcaactctt agacgctggt cttaaatctc cagcttcacc aggttctatt
     1981 attgcgatta tggctacggc gccaaaaggt gtttggcctc atctaaatgt tcttttaggt
     2041 gttttagtgg cagcagttgt ttctttcctt gtagcagccc ttattcttca tgcagacaag
     2101 tcaactgagg attcgctcga agctgctcag gcggctaccc aagcagctaa ggctcagtct
     2161 aaaggtcagt tagtatcaac ttctgttgat gcagttgttt cgacagactc agtggaaaaa
     2221 atcattttcg cctgcgatgc tggtatggga agctctgcta tgggagctag tattcttcga
     2281 gataaggtta aaaaagcagg tctagagatt ccagtatcta atcaggcaat ctcaaatttg
     2341 cttgatacac caaaaacatt aattgttact caggaagaac tgacaccaag agctaaagac
     2401 aagagtccaa gtgctattca tgtttctgtt gataatttct tagcgtcccc tcgttatgat
     2461 gaaattgtag cttcattaac aggagctttt ccaatagcag aaattgaagg agatatacca
     2521 acttcagcac cagtagatag tcaggaaatt gaccttaacc atattgatgc tgtagtagtt
     2581 gcttatggta aagcacaggg aactgcaact atgggctgtg aaacgattcg ggctatcttt
     2641 agaaacaaga atattcgtat tccagtttct actgccaaaa tttcagaatt aggtgaattt
     2701 aattctaaaa acataatgat tgtaacaact atttctttac aggcagaagt gcagcaagca
     2761 gcaccgaatt ctcaatttct tattgtggat agtttagtaa caacaccaga atatgacaaa
     2821 atggctgcta gaatgtacaa atagaactag aggtttctaa attacgaatg ctattaacca
     2881 aacgagaaga acaattattg aaggctttcc tacatgtagg gaagctttca atgcaagata
     2941 tgactgaaat cttacaggtt tcatctagaa caatttatcg aactttatca gatttgacag
     3001 atagcatgga gcaatatgga atcgaaataa cgaagcatgg gaaatactat attttgactg
     3061 gagagttgga tgatttgccg acagaacttg aagtgttagt tgagtatagt ccccaagaaa
     3121 gacaagagtt gattacctat cgccttctga ctgagagcgg ttttgtcacc aatgaagcat
     3181 tgcaagagtg cacgaaagtc agtaatgtaa ctattattca ggatatttca gatattgata
     3241 agcgtctttt agactttgat ctgaaaattg aacgacaaaa aggttatcgg atttctggtg
     3301 attcagttgg taagagaaga tttttggcta ttttactgac aaactgtatc tcagtagcag
     3361 atttttcaac cggtaatttt gggagctttg atattttaga agcagataga actaggctgg
     3421 ccagtcagat tgttaataag caactgtcag gttttccaga tatggatgct aggatgaaga
     3481 tgttttttgc gatcttgtta tctcttatag gtcaggagca aaacattgaa aattcaccta
     3541 atactagtaa gcaggctttg gaaatttctc aaaaaatttt tcaagcttac tctaagcaga
     3601 ctgcacaatt ttatagtatt caggaaatta tctattttgc gagcatcttg gatgaattaa
     3661 tcattaaacg tcaggacaat ccgctcttta cggagaaatt tgatggtgaa tttttctaca
     3721 atatttcaaa tctgattgat acggtttcca tgtataccaa gattgacttt tttaaggaca
     3781 aggttttatt caattttctt ttccatcata ttcggctcag tttaggcgtc cctatccttt
     3841 ttcagggtga aaatttgcca gaatctatcc agattttagt tgaaaggaat aaatttcttt
     3901 atacagtcat cagtctttta gtgaatgata tttttccgaa atatcttcat acagagtatg
     3961 agtatggcat gattgcccta cattttatct ctagcttagg ccgtagtcca gagatttatc
     4021 cagtccgtgt tttgctttta acggatgaac gtcgggtcac tagagattta ttagtcagta
     4081 aaattaagag tgttgctcct tttgtagagt tgatagatat tcagtctcta gtagattacc
     4141 acagtattga tctcagtcag tatgattata ttttatctac caagccgctg actaatcagg
     4201 aaatcgatgt aatttctagt tttccaaccg tcaaagaatt gcttgaatta caggaacgac
     4261 ttcagtatgt acaggcacat cgtacaattg tcgcgcgtga tgctatcgct ccagagaaaa
     4321 gttatgactt gcaagattat ttaatatcta gtagtcagct tttgagtcaa tttgagttgg
     4381 ttcaattgga gaataatcaa tcatttgagc acacggtaga acaaatcatc caatatcaga
     4441 agaatgtgag tgacagagat tacctaacaa gaaaattgtt atctcacttc cagaatagtc
     4501 ctatggctat tcctaatact ggtctggtgc ttttacatag tcagtctagc aaagtaacaa
     4561 caaatagttt tactatgttt gaactcaaac tacctatctc cgcattgtca atgaaacgag
     4621 aggaagaaga ggtcaaaagg tgtctgctaa tgctaatgtc taaagaagct agcgaggaag
     4681 cgagagattt aatgacagct attagtcagt cgattattga aaatcatctt tatacagaga
     4741 tttacaagac gggaaatcaa tccattattt atcagatgct aaatactatt tttaacgaaa
     4801 aaattaagaa attggagaac taatatgaaa cttgaaaaac atttgattaa gcttaataaa
     4861 caattttcta acaaggagga agctatttgt tattgtgggc aagttcttta tgagggtgga
     4921 tatgttaatg aagactatat tgaagccatg attgagcgag ataaagagct atctgtttac
     4981 atgggtaact ttatcgccat accgcatgga acagatgcag caaaaaagga tgtactcaag
     5041 tctggtatta cagtcgttca agtccctaga ggggttgatt ttgggaatgt atctaaccct
     5101 caagtggcaa cggttctttt tggtattgct ggtattggta atgaacactt agaaattatt
     5161 cagaaaattt ctatcttctg tgcagatgta gataatgttc ttaaactagc agatgctcag
     5221 tcaaaagagg aagtattgcg cttatttgat gctgttgaat aattgaattt cgtcatttgt
     5281 catctagtat atatgtccct caaataggaa aaggagaaat tgaatgaaac attctgttca
     5341 ttttggtgcc ggtaatatcg gtcgtggttt tataggtgaa attctattta aaaatggttt
     5401 ccatattgat tttgtggatg tcaataatca gataattcat gctctaaatg aaaagggcaa
     5461 gtatgaaatt gaaattgcac agaaaggaca gtctcgtata gaagtaacta atgtggctgg
     5521 cattaatagc aaagaacatc ctgagcaagt cattgaagcg attcaaaaga cggatattat
     5581 tactactgca atcggaccta atatactccc ttttatcgcc gaacttctag ccaaaggaat
     5641 cgaagctcgc cgagttgcag gaaatacaca ggcattggat gttatggcct gtgaaaatat
     5701 gattggcggg tctcaatttc tttatcaaga agtcaagaaa tatttaagtc cggaaggttt
     5761 gacatttgct gataactaca taggttttcc aaatgctgca gtagacagga ttgttccagc
     5821 acaaagtcac gaagattccc tttttgttgt ggtcgagccc tttaatgaat gggtcgtgga
     5881 aaccaagcgt cttaaaaatc cagatttacg tctaaaagat gtgcattatg aagaagattt
     5941 agaacccttt attgagcgaa aacttttttc agtcaattct ggacatgcaa cttcagctta
     6001 cattggtgcg cattatggtg ccaagacaat tttggaagct cttcaaaatc ctaatattaa
     6061 atctcggatt gaatctgtat tagctgaaat tcggagtctc ttgattgcca aatggaactt
     6121 tgataaaaaa gaattggaga attatcacaa agtcattata gaacggtttg aaaacccttt
     6181 catagtggac gaggttagtc gcgtagctcg tactccaatc cgaaaattag gctataatga
     6241 acgattcatc cggccgatac gtgaattgaa agaactcagt ttgtcatata aaaacctact
     6301 taaaacagtt ggctatgcct ttgactatcg cgatgtaaat gatgaagaaa gtattcgatt
     6361 aggtgaattg ttggctaaac aatcagtcaa agatgttgtt atacaagtta caggtttaga
     6421 cgaccaagaa ttgattgagc aaattgtaga gtatatttaa tctttttcga aaatctcttc
     6481 aaatcaggtt agcatcgctt tgtcttaggc atatgttgtt ctatctacaa cctcaaagca
     6541 gtgctttgag ctgactccgt cagtcttgtc tgcaacctca aaacactgtt tgagttatct
     6601 gcggtaatct ttctagcttg tctttgattt ttgttgttat ttataaggta aaagaagctg
     6661 gacaaaaagt cttcaaaatc ggaaaaaggc agcctatcgg gtgttcaaaa atcttgatag
     6721 gatgtccttt attatggaaa gccttattgg attttctcct cagattgagt ttttgatcag
     6781 ctttatgaga taggttttgc tagagatgta gcccatcatg ttatttttat ggacggtggg
     6841 aaaattgttg aaaaaaataa tgcccatcaa ttctttagtc gtccaagaga agaacgaacc
     6901 aagcaatttt ggaacgaatt ctttcgaatg cgatctatat agtaaaatga aacaagaaca
     6961 ggacaaatcg atcaggacag tcaaatcgat ttctaacaat gttttagaag tagaggtgta
     7021 ctattctagt ttcaatctac tatataactg aaaaattaga taaattagtt ttggaaaatg
     7081 actaaccaaa agatatccaa agtagtctaa aattgtctat actttatgag tgttttagtt
     7141 aggaaaaagg cttgttgtct ataattggct gcattagtct agattttatt tatagaaaat
     7201 gttataatag actgtattta aaaaatttta aggagaaatg acagaatgtc tgtatcattt
     7261 gaaaacaaag aaacaaaccg tggtgtcttg actttcacta tctctcaaga ccaaatcaaa
     7321 ccagaattgg accgtgtctt caagtcagtg aagaaatctc ttaatgttcc aggtttccgt
     7381 aaaggtcacc ttccacgtcc tatcttcgac aaaaaatttg gtgaagaatc actttaccaa
     7441 gacgttatga acgctctttt gccaaacgct tatgaagcag ctgtaaaaga agctggtctt
     7501 gaagtggttg cccaaccaaa aattgacgta acttcaatgg aaaaaggtca agactgggtt
     7561 atcgctgctg aagtcgttac aaaacctgaa gtaaaattgg gtgactacaa aaaccttgaa
     7621 gtatcagttg atgtagaaaa agaagtaact gacgctgatg ttgaagagcg
//
LOCUS       DBMVGT010000074         7176 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.074, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000074 DBMVGT010000000
VERSION     DBMVGT010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7176)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7176)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7176
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.074"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..995)
                     /locus_tag="AC0DU4_001796"
     CDS             complement(<1..995)
                     /locus_tag="AC0DU4_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HIN4237719.1"
                     /translation="MKKFYVSPIFPILVGLIAFGVLSTFIIFVNNNLLTVLILFLFVG
                     GYVFLFKKLRVHYTRSDVEQIQYVNHQAEESLTALLEQMPVGVMKLNLSSGEVEWFNP
                     YAELILTKEDGDFDLEAVQTIIKASVGNPSTYAKLGEKRYAVHMDASSGVLYFVDVSR
                     EQAITDELVTSRPVIGIVSVDNYDDLEDATSESDISQINSFVANFISEFSEKYMMFSR
                     RVSMDRFYLFTDYTVLEGLMNDKFSVIDAFREESKQRQLPLTLSMGFSYGDGNHDEIG
                     KVALLNLNLAEVRGGDQVVVKENDETKNPVYFGGGSAASIKRTRTRTRAMMTAIS"
     gene            complement(1131..1679)
                     /gene="hpf"
                     /locus_tag="AC0DU4_001797"
     CDS             complement(1131..1679)
                     /gene="hpf"
                     /locus_tag="AC0DU4_001797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000599099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0045182 - translation regulator activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome hibernation-promoting factor, HPF/YfiA
                     family"
                     /protein_id="HIN4237720.1"
                     /translation="MIKYSIRGENLEVTEAIRDYVVSKLEKIEKYFQPEQELDARINL
                     KVYREKTAKVEVTIPLGSITLRAEDVSQDMYGSIDLVTDKIERQIRKNKTKIERKNKN
                     KVATGQLFTDALVEDSNIVQSKVVRSKQIDLKPMDLEEAILQMDLLGHDFFIYVDVED
                     QTTNVIYRREDGEIGLLEVKES"
     gene            complement(1759..2421)
                     /locus_tag="AC0DU4_001798"
     CDS             complement(1759..2421)
                     /locus_tag="AC0DU4_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0030420 - establishment of competence for
                     transformation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HIN4237721.1"
                     /translation="MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEEN
                     CPNCMKTELSTKCQDCQLWCKEGVEVSHRAIFTYNQAMKDFFSRYKFDGDFLLRKVFA
                     SFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
                     KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSL
                     VR"
     gene            complement(2418..3716)
                     /locus_tag="AC0DU4_001799"
     CDS             complement(2418..3716)
                     /locus_tag="AC0DU4_001799"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HIN4237722.1"
                     /translation="MKVNLDYLGRLFTENELTEEERQLAEKLPAMRKEKGKLFCQRCN
                     STILEEWYLPIGAYYCRECLLMKRVRSDQTLYYFPQEDFPKQDVLKWRGQLTPFQEKV
                     SEGLLQAVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKR
                     LQQDFSCGIALLHGESEPYFRTPLVVATTHQLLKFYQAFDLLIVDEVDAFPYVDNPTL
                     YHAVKNSVKENGLRIFLTATSTNELDKKVRLGELKRLSLPRRFHGNPLIIPKPIWLSD
                     FNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLEEILQEQFPNEKIGFVS
                     SVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGG
                     RVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQMMNKEAGL"
     gene            3772..4407
                     /locus_tag="AC0DU4_001800"
     CDS             3772..4407
                     /locus_tag="AC0DU4_001800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HIN4237723.1"
                     /translation="MEFRTIKEDGQVQEEIKKSRFICHAKRVYSEEEARDFITAIKKE
                     HYKATHNCSAFIIGERSEIKRTSDDGEPSGTAGVPMLGVLENHNLTNVCVVVTRYFGG
                     IKLGAGGLIRAYAGSVALAVKEIGIIEIKEQAGIAIQMSYAQYQEYSNFLKEHDLMEL
                     DTNFTDQVDTMIYVDKEEKETIKAALVEFFNGKVTLTDQGLREVEVPVNLV"
     gene            4692..5612
                     /gene="cysK"
                     /locus_tag="AC0DU4_001801"
     CDS             4692..5612
                     /gene="cysK"
                     /locus_tag="AC0DU4_001801"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004124 - cysteine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HIN4237724.1"
                     /translation="MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVK
                     DRIALSMIEKAEQDGILKPGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVER
                     RKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
                     ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPH
                     KIQGISAGFIPDTLDTKAYDGIVRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIE
                     VAKKLGTGKKVLVLAPDNGERYLSTALYEL"
     gene            complement(5851..6225)
                     /locus_tag="AC0DU4_001802"
                     /pseudo
     CDS             complement(5851..6225)
                     /locus_tag="AC0DU4_001802"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_050084071.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family transposase"
     gene            6198..6485
                     /locus_tag="AC0DU4_001803"
                     /pseudo
     CDS             6198..6485
                     /locus_tag="AC0DU4_001803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(6626..6841)
                     /gene="tnpB"
                     /locus_tag="AC0DU4_001804"
     CDS             complement(6626..6841)
                     /gene="tnpB"
                     /locus_tag="AC0DU4_001804"
                     /inference="COORDINATES: protein motif:HMM:NF017528.6"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HIN4237725.1"
                     /translation="MDSFSGQVFLFCGGRKDRFKALYWDGQGFWLLYKRFENGKLTWL
                     STEKDVKALAPEQVDWLMKGFSITPKI"
BASE COUNT         2285 a         1480 c         1218 g         2193 t
ORIGIN      
        1 tctgaaatag ctgtcatcat agcgcgcgta cgagtccgtg tacgcttgat tgaagcagca
       61 gacccaccac caaaataaac tggatttttc gtttcgtcgt tttccttaac aaccacctgg
      121 tcgccaccac gtacttcagc caagttcaaa ttgagcaaag caactttccc tatctcatca
      181 tgatttccat cgccataaga aaatcccata cttaaggtca agggcaactg tctctgtttc
      241 gactcttctc tgaaagcatc aataacagaa aatttatcat tcatcaagcc ctcaagcacc
      301 gtgtagtcag taaatagata aaatcgatcc atacttaccc gacgagaaaa catcatgtat
      361 ttttctgaaa actctgatat aaaattagct acaaaactat tgatttgact aatatctgac
      421 tcagaagttg catcctccaa atcatcataa ttatccacag agacaatccc aatcactggt
      481 cgacttgtta ccaattcatc tgttatggct tgttccctgg atacatctac aaaatacaaa
      541 acaccggaag aagcatccat atgaacagca taacgcttct caccaagctt ggcataagta
      601 gacggatttc ctactgaagc cttgataatc gtttgaacag cttctaaatc aaaatcacca
      661 tcttccttgg tcaaaatcaa ttcagcatag ggattaaacc actcaacctc tccagaagat
      721 aaattcaatt tcataacacc tacaggcatc tgttccaata gagctgtcaa actttcttcc
      781 gcttggtggt ttacatactg tatctgttct acatcactcc ttgtataatg cactctcagt
      841 ttcttaaata aaaaaacata gcctcctaca aaaagaaaca aaattaaaac cgtcaacaga
      901 ttattattaa caaaaataat gaaagtggat aagactccaa acgcaatcaa tcctactaga
      961 ataggaaaaa ttggacttac ataaaatttt ttcattcaaa acctcttggc acccattata
     1021 ccataatacc cctcaaaaag cgacttttta aaagtgtaat cagtaattct atcaattata
     1081 agaaaaaggt agtttacaat tcagtaaacc tacctttaca catattgaaa ttaagattct
     1141 ttaacctcta acaaaccaat ttcgccatcc tcacgacgat aaatcacatt ggttgtctga
     1201 tcttcaacat ccacatagat aaagaaatca tgccccaata aatccatttg tagaattgct
     1261 tcttccaaat ccattggttt taaatcaatt tgttttgaac gaacaacttt agactggaca
     1321 atatttgaat cttccaccaa agcatctgta aataattgac cagttgctac cttattttta
     1381 tttttacgct cgatttttgt tttattttta cgaatctgac gttcaatttt atcagttaca
     1441 aggtcaattg aaccatacat atcttgagat acatcttctg cgcggagagt aatagatcca
     1501 agcggaatcg ttacttccac tttagccgtt ttttcacgat aaacttttaa gttaattcgg
     1561 gcatccaact cttgttctgg ttggaagtac ttttcgatct tttcgagttt agaaactaca
     1621 taatcacgaa ttgcttctgt tacttctagg ttttcaccac ggatactata tttaatcata
     1681 tgagtacctt ctttctaaac atttttgttt ttatgatttt attataacgc tttcattcta
     1741 tttttgcaaa ttttttcctc atcttacaag ggaaaatgtt tttacatcct tagcaccagc
     1801 ttcttccaac agtttcttaa cacgatttat agttgctcct gtagtataga tatcatctat
     1861 aagtaggatt tttttaggaa tagtgactcc acttttaata aagaaaggaa gttctgtccc
     1921 caagcgctct gaacgatttt tagaagaact ggctctctct tctcttttct ctaataaatc
     1981 cagatactca aagcctgctg cctctaccaa gccctcaacc tgattaaatc ctctgttagc
     2041 atatctatca ggacttaggg gaattacaac aaattgatac tctttgtact ttttcaactc
     2101 ctcacttaaa aatgaagcga aaacttttct taacaggaag tctccatcaa acttataccg
     2161 actgaaaaaa tccttcatag cttgattgta agtaaaaatc gctctatgac tgacttcaac
     2221 tccttcttta caccaaagtt gacagtcttg acactttgtt gacaactctg ttttcataca
     2281 atttggacag ttctcttccc caattctttc aaaagtagaa tcacagtctg aacaaagaca
     2341 agagtcatca ttcctcagaa gtaagagact actaaaagtt aaaacagtct tcatagtctg
     2401 cccacataac aagcacttca tagaccagcc tccttattca tcatctgaat ttccttaatc
     2461 gccttcttga ttgaagcatt taacccatca tggaagaaaa gcaaatctcc tgtcggtcta
     2521 tccatgcttc gtccaactcg tccaccaatc tgaatcaaac tagacttggt aaacaaacga
     2581 tgattggcct ctactacgaa aacatccaca caagggaagg taactccacg ctccaagatt
     2641 gtcgtactga taagtattgt cagttctcca tctcgaaaag cttgtacttg ctctaatcga
     2701 tcctctgtta cagaagatac aaagccaatt ttctcatttg gaaattgctc ctgtaagatt
     2761 tcttctaact gctccccttt cttaatttct gaagcaaaaa tgagtaacgg ataagctgtc
     2821 tttctctgct tctcaatata ggactttaac tttggtgaca aacgattctt gtctaagtag
     2881 cgattaaaat ccgataacca aattggtttt ggaataatca acggatttcc atgaaaccgt
     2941 ctcggtaaac tcagtctttt tagttctcct aaacggacct ttttatctaa ctcattggtc
     3001 gaagtcgctg ttaaaaagat tctcaatcca ttctccttta cactattctt gacagcgtgg
     3061 taaagcgtgg gattatcaac ataaggaaaa gcatctactt catccactat cagcaaatca
     3121 aaagcttgat aaaacttcaa taactgatgg gttgttgcaa caactagtgg tgttcgaaaa
     3181 taaggttccg attctccatg tagcaaagct atcccgcaag aaaaatcctg ttgcaggcgc
     3241 ttgtacagct ccaaacaaac atctatgcga ggactagcca aacacactgc accacccgca
     3301 ttgatcactt tagccactac ttgataaatc atttctgtct ttccagctcc tgttaccgca
     3361 tgaactaagg ttggcttttg cttgtctact gcttgaagca gtccctctga caccttctct
     3421 tgaaaaggag ttaattggcc gcgccatttg agaacatctt gcttcggaaa atcctcctgc
     3481 ggaaaatagt ataaagtttg atcacttctg actcgcttca tcagcaagca ctctcgacaa
     3541 tagtaagcac cgatgggcaa ataccattct tctagaatag tactattaca acgttgacag
     3601 aaaagtttcc ccttctcctt tctcattgct ggaagtttct ccgccaactg acgttcttct
     3661 tctgttaatt cattctcagt aaataaacga ccgagataat ctaaatttac tttcatactt
     3721 ctttattcgt aaaaactagc actttagatt attttttagt acaattaaat catggaattt
     3781 aggacaatta aagaggacgg ccaagtccaa gaagaaatca aaaaatctcg ctttatctgc
     3841 catgccaagc gtgtttatag cgaagaagag gctcgtgact tcattactgc catcaaaaaa
     3901 gaacactaca aagcgacaca taactgctct gcctttatta ttggagaacg tagtgaaatt
     3961 aaacgtacaa gtgatgatgg tgagcctagt ggtactgctg gtgttcccat gcttggggta
     4021 ctagaaaatc acaatctcac caatgtctgt gtggtcgtga cacgctactt tggtggtatt
     4081 aaactaggcg ctggaggact aattcgtgct tacgccggca gtgtcgcctt agctgtcaaa
     4141 gaaattggta ttattgaaat aaaagaacag gctggcattg ctattcaaat gtcttatgct
     4201 cagtaccaag agtacagtaa cttccttaaa gaacatgatc tcatggagct ggatacaaac
     4261 tttacagatc aagtcgatac gatgatttat gttgataaag aagaaaaaga aactattaaa
     4321 gctgcacttg tggagttttt taatggaaaa gtcactttaa ctgaccaagg tttacgagag
     4381 gttgaagttc ctgtaaactt agtgtaaaca atgaataata cagcgtttcg ttgacattct
     4441 cacaactact ttagcgagca aaataaaaag atgcgtacca aaatatacta gaaaatgaag
     4501 caattcaaac gaaacctgat atcgttttcc ttcacaccta tttactagaa ttaactgaac
     4561 gcaatcactt gaaaattaat gactttgatc tatgatatat agaaatccta tcgcttcgat
     4621 aggatttcta tattttacaa atggtatgga tagcgttata ctaaagatat cttatacaaa
     4681 gaggtattca tatgtctatt tataacaaca ttactgaatt aatcggtcaa acaccgattg
     4741 ttaaacttaa caacatcgtg ccagaaggtg ctgcagacgt ctatataaag cttgaagcat
     4801 ttaatcctgg ttcatctgta aaagaccgta ttgcccttag catgattgaa aaagctgaac
     4861 aagatggtat tctgaaacct ggttctacta ttgttgaagc aacaagtgga aacactggta
     4921 ttggactttc atgggtaggt gctgctaaag ggtataaagt cgtcatcgtt atgcctgaaa
     4981 ctatgagtgt agaacgacgt aaaattatcc aagcttatgg tgctgaactc gtcctaactc
     5041 ctggtagcga gggaatgaaa ggtgctattg ctaaggctca agaaatcgct gctgaacgtg
     5101 atggtttcct tcctcttcaa tttgacaatc cagctaatcc agaagtacac gaaagaacaa
     5161 caggagctga gatactagct gctttcggta aagatggatt agatgccttt gttgctggag
     5221 taggtaccgg tggaacgatt tctggtgttt ctcatgcact caaatcagaa aattctaaca
     5281 ttcaagtttt tgcagtagaa gcagatgaat ctgctattct atctggtgaa aaacctggtc
     5341 ctcacaaaat tcaaggtatc tcagctggat ttattcctga tacacttgat actaaagcct
     5401 atgatggtat cgttcgtgta acatcagatg acgctcttgc actcggacgt gaaattggtg
     5461 gaaaagaagg cttccttgta gggatttcct cagctgcagc tatctacgga gccatcgagg
     5521 ttgccaaaaa attaggtaca ggtaaaaaag tccttgtcct agcaccagat aacggtgaac
     5581 gttatctctc tacagcactt tatgaattgt aaccgtccaa taacgaagta tattgaaaaa
     5641 tctccagact agagaactca cggatagttc ctaatctgga gatttcttat ttgcactttt
     5701 cttgtacaac tttagtccat ggtaaataag cctctaaaac ctctttgttt acgagagttt
     5761 ccacgtttgg aagacattct agaagatagg atagatattt ctcactattt ataatggatt
     5821 gaaataagat atgaacaaat cgattaggac atgatggtaa agcgtaatcc cttgtttctc
     5881 agctttccca gacaaaaaag tccaatagta agtcagctga ctatcactct ctagcaccct
     5941 ataagaagtt tcatccgcat gaagtaaggg ctgagtcaat agtctctctc gcaagaggtt
     6001 atagaggggc tccaaatagt attgactcgt cttgatatgc caattagaga tttccttgcg
     6061 tgtgattggt aaacccatct tagcccaatc ttcttcttgg cgataattgg gtaccttcag
     6121 attaaacttc tgatggatgg tgtgagcgat aatagaagct gagccaaagc tatgcgctaa
     6181 aggggcttta ggaataggag ctttcacaag cttatccaga tgattatctt ttactcgtta
     6241 tggacaatgc tatatggcat aaatcaagta ccttaaagat tccgactaat attggctttg
     6301 catttattcc tccatacaca ccagagatga accccattga acaagtgtgg aaagagattc
     6361 gtaaacgtgg atttaagaat aaagcctttc gaactttgga agatgtcata caaggactgg
     6421 agaaggaggt gataaagtcc atcgttaatc ggagatggac tagaatgctt tttgaaagca
     6481 gatgagtgta aaaagaaagt cctcatttca atagaaatca caactttctg atggatttat
     6541 agtaaaatga aataagaaca ggacaatcaa atcgatttct aacaatgttt tagaagcaga
     6601 ggtgtactat tctagtttca atctactata tttttggagt gatagaaaag cccttcataa
     6661 gccaatctac ttgttcaggt gcgagagctt tgacatcctt ttctgtactt agccaagtca
     6721 gttttccgtt ctcaaagcgt ttatatagta gccaaaatcc ttgaccatcc cagtaaaggg
     6781 ctttaaagcg gtctttacgt ccaccacaaa agagaaagac ttgaccggag aaagaatcca
     6841 attcaaagtg ggttttaact acataggcta atgagtctat tccctacctc atatctgtct
     6901 tgccacaaac aaggtgaact tgacctaaat cacttagttg aattatcata gtacaatacc
     6961 tttcctccga taattatttt ttatctagta tactggaagt tggggaatta ggatagatac
     7021 cttgttatga cgcgcttact atgaatttga agtatagtct cctaaatgca cttagccctt
     7081 attatagggc tttttgtttt aattattcta atcgagtgag actggggaaa aaacaatttc
     7141 aggaaaaatc taagccctat acaaaaaagg aagcaa
//
LOCUS       DBMVGT010000075         7166 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.075, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000075 DBMVGT010000000
VERSION     DBMVGT010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 7166)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7166)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7166
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.075"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..476
                     /locus_tag="AC0DU4_001805"
     CDS             <1..476
                     /locus_tag="AC0DU4_001805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="uridine kinase"
                     /protein_id="HIN4237726.1"
                     /translation="NLLETDPYITSGRYLVVPKDAPNQKVTASLPVAHELESLQRDIL
                     ALQAGMDVLTIEEPWKASEVLSGAKPILIVEGMSVGFLPKELFEKTICFYTDEETELK
                     RRLARDTTVRNRYASFILASHQMRREQYLRYYKETESKADILVDQSEDKFDVKRT"
     gene            742..1050
                     /gene="rpsJ"
                     /locus_tag="AC0DU4_001806"
     CDS             742..1050
                     /gene="rpsJ"
                     /locus_tag="AC0DU4_001806"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HIN4237727.1"
                     /translation="MANKKIRIRLKAYEHRTLDTAAAKIVESATRTGAQVAGPIPLPT
                     ERSLYTIIRATHKYKDSREQFEMRTHKRLIDIVNPTQKTVDALMKLDLPSGVNVEIKL
                     "
     gene            1267..1893
                     /gene="rplC"
                     /locus_tag="AC0DU4_001807"
     CDS             1267..1893
                     /gene="rplC"
                     /locus_tag="AC0DU4_001807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HIN4237728.1"
                     /translation="MTKGILGKKVGMTQIFTEAGELIPVTVIEATPNVVLQVKTVETD
                     GYNAIQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNVEGLEVGAEITVETFAA
                     GDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKGKNLAG
                     RMGGDRVTIQNLEVVQVVPEKNVILIKGNVPGAKKSLITIKSAVKAGK"
     gene            1918..2541
                     /gene="rplD"
                     /locus_tag="AC0DU4_001808"
     CDS             1918..2541
                     /gene="rplD"
                     /locus_tag="AC0DU4_001808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HIN4237729.1"
                     /translation="MANVTLFDQTGKEAGQVVLNDAVFGIEPNESVVFDVIISQRASL
                     RQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLP
                     QKVRRLALKLVYSEKVAENKFVAVDALSFTAPKTAEFAKVLAALSIDSKVLVILEEGN
                     EFAALSARNLPNVKVATATTASVLDIANSDKLLVTQAAISKIEEVLA"
     gene            2541..2837
                     /locus_tag="AC0DU4_001809"
     CDS             2541..2837
                     /locus_tag="AC0DU4_001809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HIN4237730.1"
                     /translation="MNLYDVIKKPVITESSMAQLEAGKYVFEVDTRAHKLLIKQAVEA
                     AFEGVKVANVNTINVKPKAKRVGRYTGFTNKTKKAIITLTADSKAIELFAAEAE"
     gene            2855..3688
                     /gene="rplB"
                     /locus_tag="AC0DU4_001810"
     CDS             2855..3688
                     /gene="rplB"
                     /locus_tag="AC0DU4_001810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019790357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_function: GO:0016740 - transferase activity [Evidence
                     IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HIN4237731.1"
                     /translation="MGIRVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVALKSKAGRN
                     NNGRITVRHQGGGHKRFYRLVDFKRNKDNVEAVVKTIEYDPNRSANIALVHYTDGVKA
                     YIIAPKGLEVGQRIVSGPEADIKVGNALPLANIPVGTLIHNIELKPGRGGELVRAAGA
                     SAQVLGSEGKYVLVRLQSGEVRMILGTCRATVGVVGNEQHGLVNLGKAGRSRWKGIRP
                     TVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNE
                     K"
     gene            3792..4073
                     /gene="rpsS"
                     /locus_tag="AC0DU4_001811"
     CDS             3792..4073
                     /gene="rpsS"
                     /locus_tag="AC0DU4_001811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000533767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HIN4237732.1"
                     /translation="MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSF
                     IGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRRK"
     gene            4085..4429
                     /gene="rplV"
                     /locus_tag="AC0DU4_001812"
     CDS             4085..4429
                     /gene="rplV"
                     /locus_tag="AC0DU4_001812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HIN4237733.1"
                     /translation="MAEITSAKAMARTVRVSPRKSRLVLDNIRGKSVADAIAILTFTP
                     NKAAEIILKVLNSAVANAENNFGLDKANLVVSEAFANEGPTMKRFRPRAKGSASPINK
                     RTAHITVAVAEK"
     gene            4442..5095
                     /gene="rpsC"
                     /locus_tag="AC0DU4_001813"
     CDS             4442..5095
                     /gene="rpsC"
                     /locus_tag="AC0DU4_001813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HIN4237734.1"
                     /translation="MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFVQK
                     ELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAKLNKLTGKQVHINI
                     IEIKQPDLDAHLVGEGIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGAD
                     IARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK"
     gene            5099..5512
                     /gene="rplP"
                     /locus_tag="AC0DU4_001814"
     CDS             5099..5512
                     /gene="rplP"
                     /locus_tag="AC0DU4_001814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003029477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_function: GO:0019843 - rRNA binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HIN4237735.1"
                     /translation="MLVPKRVKHRREFRGKMRGEAKGGKEVAFGEYGLQATTSHWITN
                     RQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKV
                     MFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE"
     gene            5522..5728
                     /gene="rpmC"
                     /locus_tag="AC0DU4_001815"
     CDS             5522..5728
                     /gene="rpmC"
                     /locus_tag="AC0DU4_001815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006739716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HIN4237736.1"
                     /translation="MKLNEVKEFVKELRGLSQEELAKRENELKKELFELRFQAATGQL
                     EQTARLKEVKKQIARIKTVQSEAK"
     gene            5753..6013
                     /gene="rpsQ"
                     /locus_tag="AC0DU4_001816"
     CDS             5753..6013
                     /gene="rpsQ"
                     /locus_tag="AC0DU4_001816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HIN4237737.1"
                     /translation="MERNNRKVLVGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKK
                     YKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEEAVII"
     gene            6039..6407
                     /gene="rplN"
                     /locus_tag="AC0DU4_001817"
     CDS             6039..6407
                     /gene="rplN"
                     /locus_tag="AC0DU4_001817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012727667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HIN4237738.1"
                     /translation="MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVK
                     QATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIREDKTPRGTRIFGPV
                     ARELREGGFMKIVSLAPEVL"
     gene            6485..6790
                     /gene="rplX"
                     /locus_tag="AC0DU4_001818"
     CDS             6485..6790
                     /gene="rplX"
                     /locus_tag="AC0DU4_001818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011921687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HIN4237739.1"
                     /translation="MFVKKGDKVRVIAGKDKGTEAVVLTALPKVNKVIVEGVNIVKKH
                     QRPTNELPQGGIIEKEAAIHVSNVQVLDKNGVAGRVGYKFVDGKKVRYNKKSGEVLD"
     gene            6814..>7166
                     /gene="rplE"
                     /locus_tag="AC0DU4_001819"
     CDS             6814..>7166
                     /gene="rplE"
                     /locus_tag="AC0DU4_001819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HIN4237740.1"
                     /translation="MANRLKEKYLNEVVPALTEQFNYSSVMAVPKVDKIVLNMGVGEA
                     VSNAKSLEKAAEELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLD
                     KLVSVSLPRVRDFHGV"
BASE COUNT         2335 a         1432 c         1561 g         1838 t
ORIGIN      
        1 taaatttgct agaaacagat ccctatatca cctccggacg ctatttggta gtacccaagg
       61 acgcgccgaa tcaaaaggtg acagccagtc tgccagtggc gcatgaactg gagagtttgc
      121 agagagatat ccttgccttg caggcgggta tggatgtctt gacaattgaa gaaccttgga
      181 aggctagtga ggtcttgtct ggagccaaac caattttgat tgtcgaaggg atgtctgttg
      241 gttttctacc caaggaactc tttgaaaaaa ccatctgttt ctacacggat gaggagaccg
      301 aattaaagcg acgccttgct agagatacga ctgtgagaaa tcgctatgca tcctttatat
      361 tggctagcca tcagatgaga cgggagcagt atctgcgata ctataaagaa actgagtcta
      421 aggcggatat cttagtggac caatcagaag ataaatttga tgtcaagagg acttaactta
      481 tgtatagaag aaatatagaa gaaaatccct aattttagaa agaaaaagta ggaaaacagt
      541 ttcatcccaa aaaaacgaaa aaacctaaca aatcccttgc aatcgcaggg gatttgtgtt
      601 attctattat ggtgctgtaa attacagcct tagttttgat gcaagaggtt gcgacacgct
      661 cggttgcatt gccacgcaac accgcgtcgg ttttcttgtg gagctagcct attatcttaa
      721 atagacgaaa aggagaaaaa gatggcaaac aaaaaaatcc gtatccgttt gaaagcttac
      781 gaacaccgta cgcttgacac agcggctgca aaaatcgtag aatcagctac tcgtacaggt
      841 gcacaagttg cgggtccaat cccacttcca actgaacgta gcctctacac aatcattcgt
      901 gcgactcaca aatacaaaga ctctcgcgaa caatttgaaa tgcgtacaca caaacgtttg
      961 atcgatatcg ttaacccaac tcaaaaaaca gttgatgcct tgatgaaatt ggatcttcca
     1021 agtggtgtaa acgtagaaat caaactttaa tctaaaatat aaaagagcag aggctggtgt
     1081 ttcaatctaa ttgaacacgg gctaaactcg gtgtgaaaaa gataaacttc ctattgtccg
     1141 ctagacactg cgttagtttc ctattttcac tttgagtttg acgccctttg tatcttagac
     1201 ttgagcataa aaaacgctcg ttaaaaactt tttgaataaa aaatatagaa aaggaactat
     1261 tttctcatga caaaaggaat cttagggaaa aaagtgggaa tgactcaaat cttcactgaa
     1321 gctggcgaat tgatccctgt aacagttatt gaagcaactc caaacgttgt tcttcaagtt
     1381 aaaactgttg aaacagacgg atacaacgct atccaagttg gtttcgatga caaacgcgaa
     1441 gtattgagca acaaacctgc taaaggacat gtagcgaaag ctaacacggc tcctaagcgc
     1501 ttcattcgtg aattcaaaaa cgttgaaggc ttggaagttg gcgctgaaat cacagttgaa
     1561 acattcgcag ctggagatgt tgttgatgta actggtactt ctaaaggtaa aggtttccaa
     1621 ggtgttatca aacgccacgg acaatcacgt ggaccaatgg ctcacggttc tcgttaccac
     1681 cgtcgtccag gttctatggg gcctgttgca cctaaccgcg tattcaaagg taaaaacctt
     1741 gcaggacgta tgggtggcga ccgcgtaaca attcaaaacc ttgaagttgt acaagttgtt
     1801 ccagaaaaga acgttatcct tatcaaaggt aacgtaccag gtgctaagaa atctcttatc
     1861 actatcaaat cagcagttaa agctggtaaa taataaagaa aggggaaatc agtcacaatg
     1921 gcaaacgtaa cattatttga ccaaactggt aaagaagctg gccaagttgt tcttaacgat
     1981 gcagtatttg gtatcgaacc aaatgaatca gttgtgtttg atgtaatcat cagccaacgc
     2041 gcaagccttc gtcaaggaac acacgctgtt aaaaaccgct ctgcagtatc aggtggtgga
     2101 cgcaaaccat ggcgtcaaaa aggaactgga cgtgctcgtc aaggttctat ccgctcacca
     2161 caatggcgtg gtggtggtgt tgtcttcgga ccaactccac gttcatacgg ctacaaactt
     2221 ccacaaaaag ttcgtcgcct agctcttaaa ttagtttact ctgaaaaagt tgctgaaaac
     2281 aaattcgtag ctgtagacgc tctttcattt acagctccaa aaactgctga atttgcaaaa
     2341 gttcttgcag cattgagcat cgattctaaa gttcttgtta tccttgaaga aggaaatgaa
     2401 ttcgcagctc tttcagctcg taaccttcca aacgtgaaag ttgcaactgc tacaactgca
     2461 agtgttcttg acatcgcaaa tagcgacaaa cttcttgtca cacaagcagc tatctctaaa
     2521 atcgaggagg ttcttgcata atgaatttgt atgatgttat caaaaaacct gtcatcactg
     2581 aaagctcaat ggctcaactt gaagcaggga aatatgtatt tgaagttgac actcgtgcac
     2641 acaaactttt gatcaagcaa gctgttgaag ctgctttcga aggtgttaaa gttgccaatg
     2701 ttaacacaat caacgtaaaa ccaaaagcta aacgtgttgg acgttacact ggttttacta
     2761 acaaaactaa aaaagctatc atcacactta cagctgattc taaagcaatc gagttgtttg
     2821 ctgctgaagc tgaataatct aaggaggaaa tatcgtggga attcgtgttt ataaaccaac
     2881 aacaaacggt cgccgtaata tgacttcttt ggatttcgct gaaatcacaa caagcactcc
     2941 tgaaaaatca ttgcttgttg cattgaagag caaggctggt cgtaacaaca acggtcgtat
     3001 cacagttcgt caccaaggtg gtggacacaa acgtttctac cgtttggttg acttcaaacg
     3061 taataaagac aacgttgaag cagttgttaa aacaatcgag tacgatccaa accgttctgc
     3121 aaacatcgct cttgtacact acactgacgg tgtgaaagca tacatcatcg ctccaaaagg
     3181 tcttgaagta ggtcaacgta tcgtttcagg tccagaagca gatatcaaag tcggaaacgc
     3241 tcttccactt gctaacatcc cagttggtac tttgattcac aacatcgagt tgaaaccagg
     3301 tcgtggtggt gaattggtac gtgctgctgg tgcatctgct caagtattgg gttctgaagg
     3361 taaatatgtt cttgttcgtc ttcaatcagg tgaagttcgt atgattcttg gaacttgccg
     3421 tgctacagtt ggtgttgtcg gaaacgaaca acatggactt gtaaaccttg gtaaagcagg
     3481 acgtagccgt tggaaaggta tccgcccaac agttcgtggt tctgtaatga accctaacga
     3541 tcacccacac ggtggtggtg aaggtaaagc accagttggt cgtaaagcac catctactcc
     3601 atggggcaaa cctgctcttg gtcttaaaac tcgtaacaag aaagcgaaat ctgacaaact
     3661 tatcgttcgt cgtcgcaacg agaaataata ttaaactagt cgcttaagca actagtaaat
     3721 ccgccagctc ggtagcgctc cataggagtg caagccgctg tggtacaaca tttaaaggag
     3781 aaaatataaa aatgggacgc agtcttaaaa aaggaccttt cgtcgatgag catttgatga
     3841 aaaaagttga agctcaagct aacgacgaaa agaaaaaagt tattaaaact tggtcacgtc
     3901 gttcaacgat cttcccaagt ttcattggtt acactattgc agtttatgac ggacgtaaac
     3961 acgtacctgt ttacatccaa gaagacatgg taggccacaa acttggtgaa tttgcaccaa
     4021 ctcgtactta caaaggtcac gctgcagacg acaagaaaac acgtagaaaa taaggagaac
     4081 ataaatggca gaaattactt cagctaaagc aatggctcgt acagtacgtg tttcacctcg
     4141 taaatcacgt cttgttcttg ataacatccg tggtaaaagc gtagccgatg caatcgcaat
     4201 cttgacattc actccaaaca aagctgctga aatcatcttg aaagttttga actcagctgt
     4261 agctaacgct gaaaacaact ttggtttgga taaagctaac ttggtagtat ctgaagcatt
     4321 cgcaaacgaa ggaccaacta tgaaacgttt ccgtccacgt gcgaaaggtt cagcttcacc
     4381 aatcaacaaa cgtacagctc acatcactgt agctgttgca gaaaaataag gaggtaaaat
     4441 cgtgggtcaa aaagtacatc caattggtat gcgtgtcggc atcatccgtg attgggatgc
     4501 caaatggtat gctgaaaaag aatacgcgga ttaccttcat gaagatcttg caatccgtaa
     4561 attcgttcaa aaagaacttg ctgacgcagc agtttcaact attgaaatcg aacgcgcagt
     4621 aaacaaagtt aacgtttcac ttcacactgc taaaccaggt atggttatcg gtaaaggtgg
     4681 tgctaacgtt gatgcactcc gtgcaaaact taacaaattg actggaaaac aagtacacat
     4741 caacatcatc gaaatcaaac aacctgattt ggatgctcac cttgtaggtg aaggaattgc
     4801 tcgtcaattg gagcaacgtg ttgctttccg tcgtgcacaa aaacaagcaa tccaacgtgc
     4861 aatgcgtgct ggagctaaag gaatcaaaac tcaagtatca ggtcgtttga acggtgcaga
     4921 tatcgcccgt gctgaaggat actctgaagg aactgttccg cttcacacac ttcgtgcaga
     4981 tatcgattac gcttgggaag aagcagatac tacatacggt aaacttggtg ttaaagtatg
     5041 gatctaccgt ggtgaagttc ttccagctcg taaaaacact aaaggaggta aataaccaat
     5101 gttagtacct aaacgtgtta aacaccgtcg tgagttccgt ggaaaaatgc gcggtgaagc
     5161 aaaaggtgga aaagaagtag cattcggtga atacggtctt caagctacaa ctagccactg
     5221 gatcactaac cgccaaatcg aagctgctcg tatcgccatg actcgttaca tgaaacgtgg
     5281 tggtaaagtt tggattaaaa tcttcccaca caaatcatac actgctaaag ctatcggtgt
     5341 gcgtatggga tctggtaaag gggcacctga aggttgggta gcaccagtta aacgtggtaa
     5401 agtgatgttc gaaatcgctg gtgtatctga agagattgca cgtgaagcgc ttcgacttgc
     5461 tagccacaaa ttgccagtta aatgtaaatt cgtaaaacgt gaagcagaat aaggagaagg
     5521 catgaaactt aatgaagtaa aagaatttgt taaagaactt cgtggtcttt ctcaagaaga
     5581 actcgcgaag cgcgaaaacg aattgaaaaa agaattgttt gaacttcgtt tccaagctgc
     5641 tactggtcaa ttggaacaaa cagctcgctt gaaagaagtt aaaaaacaaa tcgctcgtat
     5701 caaaacagtt caatctgaag cgaaataata gactagggaa ggagaaattt caatggaacg
     5761 caataatcgt aaagttcttg ttggacgtgt tgtatctgac aaaatggaca agacaatcac
     5821 agttgtagtt gaaacaaaac gtaaccaccc agtctatggt aaacgtatta actactctaa
     5881 aaaatacaaa gctcatgatg aaaacaatgt tgccaaagaa ggcgatatcg tacgtatcat
     5941 ggaaactcgc ccgctttcag ctacaaaacg tttccgtctt gtagaagttg ttgaagaagc
     6001 ggtcatcatc taatcaaacc tgaaaggaga aaactgaaat gattcaaaca gaaactcgtt
     6061 tgaaagtcgc agacaacagc ggtgctcgcg aaatcttgac tatcaaagtt cttggtggtt
     6121 caggacgtaa atttgcaaac atcggtgatg ttatcgtggc atctgtaaaa caagctactc
     6181 ctggtggtgc ggttaaaaaa ggtgacgttg ttaaagcagt tatcgttcgt actaaatcag
     6241 gtgctcgtcg tgctgatggt tcatacatca aatttgacga aaacgcagca gttatcatcc
     6301 gtgaagacaa aactcctcgc ggaacacgta tctttggccc agttgcacgt gaattgcgtg
     6361 aaggtggttt catgaagatc gtgtcacttg ctccagaagt actttaattt ttaggaacaa
     6421 actagtcccc tagcttcaag ctagggtgcc cttatgggcg taagaaaaat caaggagaaa
     6481 cctaatgttt gtaaaaaaag gcgacaaagt tcgcgtaatc gctggtaaag ataagggaac
     6541 agaagctgtt gtccttactg cccttccaaa agtaaacaaa gttatcgttg aaggtgttaa
     6601 cattgttaag aaacaccaac gtccaactaa cgagcttcct caaggtggta tcatcgagaa
     6661 agaagcagct atccacgtat caaatgttca agttttggac aaaaatggtg tagctggtcg
     6721 tgttggttac aaatttgtag acggtaaaaa agttcgctac aacaaaaaat caggcgaagt
     6781 gcttgattaa tcacgaagga aaggagaagt ataatggcaa atcgtttaaa agaaaaatat
     6841 cttaatgaag tagttcctgc tttgacagaa caattcaact actcatcagt gatggctgtg
     6901 cctaaagtag ataagattgt tttgaacatg ggtgttggtg aagctgtatc aaacgctaaa
     6961 agccttgaaa aagctgctga agaattggca cttatctcag gtcaaaaacc acttatcact
     7021 aaagctaaaa aatcaatcgc cggcttccgt cttcgtgaag gtgttgcgat cggtgcaaaa
     7081 gttacccttc gtggtgaacg tatgtacgaa ttcttggata aattggtatc agtttcactt
     7141 ccacgtgtac gtgacttcca cggtgt
//
LOCUS       DBMVGT010000076         6948 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.076, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000076 DBMVGT010000000
VERSION     DBMVGT010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6948)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6948)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6948
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.076"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..566)
                     /locus_tag="AC0DU4_001820"
     CDS             complement(<1..566)
                     /locus_tag="AC0DU4_001820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237741.1"
                     /translation="MLEIKNLTGGYVHVPVLKDVSFTVESGQLVGLIGLNGAGKSTTI
                     NEIIGLLAPYSGSININGLTLQGDATSYRKQIGYIPETPSLYEELTLREHIETVAMAY
                     GIEQKVAFERVEPLLKMFRLEQKLDWFPVHFSKGMKQKVMIICAFVVDPSLFIVDEPF
                     LGLDPLAISDLIQLLEVEKQKGKSILMST"
     gene            634..1044
                     /locus_tag="AC0DU4_001821"
     CDS             634..1044
                     /locus_tag="AC0DU4_001821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HIN4237742.1"
                     /translation="MSDCIFCKIIAGEIPASKVYEDEQVLAFLDISQVTLGHTLVVPK
                     EHYRNLLEMNATSASQLFAQVPKVAQKVMKVTKAAGMNIISNCEEVAGQTVFHTHVHL
                     VPRYSADDDLKIDFIAHEPDFDKLAQVAETIKNA"
     gene            1054..1341
                     /locus_tag="AC0DU4_001822"
     CDS             1054..1341
                     /locus_tag="AC0DU4_001822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237743.1"
                     /translation="MKLSNLLLFAGAAAGSYLVTKNRQTITDEVLNTTDRVQAIKDDV
                     DIIQNSLQIIDQQKELIKEYQEDLTYKFKVLEKDIQTRLAVIKEMQGTEDK"
     gene            complement(1707..2843)
                     /gene="dnaJ"
                     /locus_tag="AC0DU4_001823"
     CDS             complement(1707..2843)
                     /gene="dnaJ"
                     /locus_tag="AC0DU4_001823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001066288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0051082 - unfolded protein binding
                     [Evidence IEA];
                     GO_process: GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HIN4237744.1"
                     /translation="MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAED
                     KYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGAGGFGGFNGAGGFGGFEDIFSSF
                     FGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGT
                     SPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAH
                     SVHVKIPAGVETGQQIRLAGQGEAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLN
                     LNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPSLRGGAVGDQYVTVN
                     VVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE"
     gene            complement(3048..3401)
                     /locus_tag="AC0DU4_001824"
     CDS             complement(3048..3401)
                     /locus_tag="AC0DU4_001824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000115730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237745.1"
                     /translation="MSVNKNNLSDIADYHEKIKFFEELFNLDYNPTEMLVTVERNGNV
                     IYKEFTEVAVGKSKYDYTSVFKDVMIYFSDHICQELHLYKTQDPHYNKFEFDLAKRSL
                     KITTRDNTTIFISNE"
     gene            complement(3414..5237)
                     /gene="dnaK"
                     /locus_tag="AC0DU4_001825"
     CDS             complement(3414..5237)
                     /gene="dnaK"
                     /locus_tag="AC0DU4_001825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HIN4237746.1"
                     /translation="MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKN
                     GEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAE
                     DYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDK
                     EEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKEN
                     GIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFD
                     DLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKS
                     VNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK
                     SQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDK
                     NGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNE
                     VDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQ
                     GLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK"
     gene            complement(5717..6241)
                     /gene="grpE"
                     /locus_tag="AC0DU4_001826"
     CDS             complement(5717..6241)
                     /gene="grpE"
                     /locus_tag="AC0DU4_001826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000046028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HIN4237747.1"
                     /translation="MAQDIKNEEVEEVQEEEVVETAEETTPEKSELDLANERADEFEN
                     KYLRAHAEMQNIQRRANEERQNLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKG
                     LGMVQESLIHALKEEGIEEIAADGEFDHNYHMAIQTLPADDEHPVDTIAQVFQKGYKL
                     HDRILRPAMVVVYN"
     gene            complement(6268..>6948)
                     /locus_tag="AC0DU4_001827"
     CDS             complement(6268..>6948)
                     /locus_tag="AC0DU4_001827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcriptional repressor HrcA"
                     /protein_id="HIN4237748.1"
                     /translation="TVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQFL
                     IPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHI
                     FKEMFNENIVMAGKVNLLNFANLAAYQFFDQPQKVALEIREGLREDQMQNVRIADGQE
                     SCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQINVVNRVLTMKLTDFYRYL
                     SSNHYEVH"
BASE COUNT         1893 a         1573 c         1352 g         2130 t
ORIGIN      
        1 gtactcatga gaatagactt gcccttttgc ttctccactt ccaaaagctg aatcaaatca
       61 gaaatagcca gcggatcaag accaaggaaa ggctcatcca cgatgaaaag acttggatcc
      121 accacaaaag cacagataat catgaccttc tgcttcatcc cttttgaaaa atgaacaggg
      181 aaccagtcta atttctgttc caaacggaac atttttaaca agggctctac tcgttcgaaa
      241 gccacttttt gctcaatacc gtaagccata gcaaccgttt cgatatgctc tctgagggtc
      301 aattcctcat acagactagg cgtctcagga atgtagccaa tctgcttgcg gtagctagtc
      361 gcatctcctt gcagagtcag gccattgata ttgatggagc cactataagg tgccaacaga
      421 ccgataatct cattgatcgt cgttgatttc ccagcaccat tgagaccaat caaaccgacc
      481 aactgcccac tttcaacagt aaaggacaca tctttcaaaa caggaacatg aacatagcca
      541 cctgtcaggt ttttaatttc taacatattt tctccaaatc tggtataatg tagctatatt
      601 atatcaaaat tcagtacagt agaggtagat tttatgtcag attgcatttt ttgtaaaatc
      661 atcgcagggg aaattcctgc ttcaaaagta tatgaagatg agcaggtcct tgcctttctt
      721 gatatctctc aagtaacact aggacacacc ttggtcgtgc caaaagaaca ctatcgcaat
      781 cttttggaga tgaatgctac gagcgccagc caactctttg cccaagtacc aaaagtagct
      841 caaaaagtca tgaaagtcac taaggctgct ggtatgaata tcatttccaa ctgtgaagaa
      901 gtcgctggtc aaacagtttt tcatactcac gttcaccttg tgcctcgcta cagtgctgac
      961 gatgacctca agattgattt tatcgcccac gaaccagact ttgacaaact tgctcaagtc
     1021 gctgaaacca tcaaaaacgc ttaaggagtt gctatgaaat tatccaacct actgctattt
     1081 gcaggagctg cagccggaag ttatctggtt acaaaaaatc gccaaaccat cacagatgaa
     1141 gtcttaaata ccactgaccg cgttcaagct atcaaagacg atgtggatat tatccaaaat
     1201 agcctgcaaa tcatcgacca gcaaaaagaa cttatcaagg aataccaaga agacttgact
     1261 tacaagttta aggtcttgga aaaggatatc cagactagac tagctgtgat aaaagaaatg
     1321 cagggaactg aagataagta aaaagagccc ccggctcttt tttaaaacgt aaacaagtta
     1381 tagtgaattg aatttagaat agcacatcat agtttctaaa gcattgttag agattacttt
     1441 aaaatcctct tatcaatttg ttcatattct atttcaatct actatatata tcccatcaac
     1501 tatgcatcat aatttaggta actcatactc aataaaaatc aaaaagcaaa ctagaaagct
     1561 aggcacagac tgctcaaaac accgttttaa ggttgtggat agaactgacg aagtcagctc
     1621 aaaacactgt tttgaggttg tagatacgac tcacatatat acggcaagcc gacgctgacg
     1681 tggtttgaag agattttcga agagtattat tctccatcaa aggcatcttt aatatggtca
     1741 aagaagcctt ttttctttgg atttactttc aagtcaccag cagccgcgaa ttctttcaag
     1801 gctacttttt ggcggtcgtt caagcctgtc ggtgttacga cattaacagt aacgtattgg
     1861 tcaccaactg caccgccacg aaggctcggt gcccccttac tacgtaggcg gaatttctta
     1921 ccagtctgag ttccctctgg aataaccaat tcaacatcac cgtgaacagt tggaatatct
     1981 actgtatcac caagagccgc ttggacaaag ttgaggttga gattgtagaa gatagtcgtt
     2041 ccttcacgtt caaacttgtc gctagcttct acagaaacta ctacatacaa gtcaccataa
     2101 ggtccaccgt taaagcctgc ttcaccttga ccagcgaggc gaatttgttg acctgtttcc
     2161 acaccagcag ggattttcac atgtacgcta tgagcttgtt tctcatgacc tgttccatga
     2221 caggttgtac atggatattt gatttctttt cctcgaccgt gacagacatc acaggttact
     2281 tggcgacgca tcataccaag aggagtctgc gtatcgacgt taatgacacc agcgccatga
     2341 cagcgtccac aagtgactgg acttgtccct ggcttagcac cagagccatt acatgtacga
     2401 cagccagctt cacgatgata cttaacttcc ttctcagttc cgaagatagc ttcttcaaag
     2461 gtcaaattga cacgatactg gagatcatct ccttggcgag gagcgtttgg attgcgcgaa
     2521 gaaccgcctc cgccgaagaa acttgagaaa atatcctcaa aaccaccgaa gccacctgcc
     2581 ccattgaaac cgccgaaacc accagctcca ccaaaaccac cattggcgcc tgcagcacca
     2641 tactggtcat aggcagcacg tttttggtcg tcactcaaag tctcataggc ttcttgaact
     2701 tccttgtact tgtcctcagc accaggctcc ttgttgatat ctgggtgata ttttttggaa
     2761 agcttacgat aagccttttt gatctcgtct gccgaagcgt tttttgacac ccccagacga
     2821 tcataaaatt cagtattgtt catacaagat accaagaccg taaaattcga ctgaaaaata
     2881 ggaaatctga cgctggagcg acgctcctag acagatttct cttttttccg agaatttagg
     2941 tcgggttcaa ttcctttctt ttatattgat gagataatac tccagccact cggccctatc
     3001 cctttttacc gaaaaacaga ggctgggttg caacctctgt ggttagatta ttcatttgaa
     3061 ataaaaatgg ttgtattatc tctagtagta atcttcaaag accttttagc taaatcaaac
     3121 tcaaatttat tatagtgtgg gtcttgtgtt ttatataggt gtaactcctg acatatatga
     3181 tccgaaaagt aaatcataac atctttaaac acagaagtgt agtcatattt actcttacca
     3241 acagctactt ctgtaaattc tttataaatg acatttccat ttctttccac agtcaccagc
     3301 atttctgttg gattataatc caaattaaat aattcttcaa aaaactttat cttttcatga
     3361 taatctgcaa tgtcagaaag attattttta ttaacactca taacactagc cccttacttt
     3421 tccgtaaact ctccgtctac gacgtcatcg cctgcgtttc ctgttgcttg tgcgccttct
     3481 gctccttctt gagcttgttg cgctgctgcg gcttgttcgt agagtttaac agcaagtcct
     3541 tgagcttttt cgttcaatgc ttcaagtttt gctttcatgt cgtccaagtt gttgtcttct
     3601 tgagctttct taaggtcatc aagggcagct tgggcagcgt cacgttctgc gtcgaagcct
     3661 ttaccttcag tttccttgat tgtcttttca gtcgcaaaga ttgcttggtc tacttcatta
     3721 cgaaggtcta cttcttcttt acgtttctta tcggcttcag cgtttgcttc tgcatctttc
     3781 atcatgcggt cgatttcttc gtcagtcaaa cctgagttcg attggatgac aatagtttgt
     3841 tctttttgag ttccaaggtc tttggcctta acagacacga taccgttctt gtcgatatca
     3901 aatgttactt cgatttgagg aattccacga ggtgcagctg ggatatcagt caattggaag
     3961 cgtccaagag tcttgttatc tgctgccatt gggcgttcac cttgaagaac gtggatatca
     4021 acggctggtt ggttgtctgc tgctgttgag aagacttgtg atttagatgt tgggattgta
     4081 gtgttgcgat cgataagttt tgtaaatact ccacccattg tttcgatacc aagtgacaat
     4141 ggcgttacat caagaaggac aacatccttg acatcaccag taatcacacc accttggata
     4201 gccgcaccca tagcaactac ttcatcaggg tttactgatt tgtttggttc tttaccagtt
     4261 tcagctttaa cagcttcaac aacggcaggg atacgagttg aaccaccaac aaggataact
     4321 tcgtcgattt ctgacaagct caaacctgca tctgaaaggg cttgacgaac tggaactttt
     4381 gtacgttcaa caaggtcacg agtcaaatca tcaaatttcg cacgagttaa agtcatttcc
     4441 aagtgaagag gtccagcctc acctgcagtg ataaatggca agctgatttg tgttgaagtt
     4501 acaccagaaa ggtctttctt cgctttttca gccgcatctt tcaaacgttg cattgccatc
     4561 ttgtcagtag acaagtcgat accgttttct ttcttgaatt ctgctaccaa gtggtcaatg
     4621 attttttggt caaagtcgtc accaccaagt ttgttgtccc ctgcagttga caatacgtcg
     4681 aagacaccgt cacccaattc aaggatagag acgtcgaatg taccaccacc aaggtcaaat
     4741 accaagattt tttcttcttt gtcagtcttg tccaaaccat aagcaagagc tgctgcagtt
     4801 ggttcgttaa caatacgttc tacttcaaga ccagcaattt taccagcgtc ttttgttgct
     4861 tgacgttgag cgtcgttgaa gtaagccgga actgtgataa cagctttggt tactttctca
     4921 ccaaggtagt cttcagcgta gcctttcaag tattgaagga tcatagctga gatttcttgt
     4981 ggagtgtatt cttttccatt tgcagaaact ttttcagaag ttcccatctt agatttgata
     5041 gagataactg tatctgggtt tgtgactgct tgacgttttg cagcatcacc aacgatgatt
     5101 tctccgtttt tgaatgagac tacagatgga gttgtgcggt ttccttctgg gtttgcgatg
     5161 attttgcttt cagttccttc aagaactgca actgctgagt ttgttgtacc taagtcaata
     5221 ccgataattt tagacatgtg tttttctcct tgttagttaa ttttctattt ttctttttga
     5281 tactcttctt aagtggcgac gccgtcagag cttgacttcg tcaatctctt tgactaaact
     5341 ttgagcctaa ggtctcaaaa tttgcgcaaa tagcgccacg gcgaagagta tcgtgtttgg
     5401 ttcgcttcgc tcactattac aaagccaaac atattttatc tttcttcata gtttattgtc
     5461 gtttcggaca agttttctat tatgtaaatt gcgacacgaa gagtcgaaat cgattttatt
     5521 tcgacgacga gttagtaagg aagctaggca aacgccatag cgattgccgt tttctgacga
     5581 gttgctttag ctaccgtcag aattgccgaa tcgaacacgc cctaagctct gagtaaaaaa
     5641 gatagatttt cttgtgttca tcgaacactt cgtcaatctc ctatttttac tgcgagcttt
     5701 ttacgggctt tgtatcttag ttatacacca ctaccattgc tgggcgtagg atgcggtcat
     5761 ggagtttgta gcctttttga aagacttgag cgatggtatc tactgggtgt tcatcgtctg
     5821 ctgggagagt ttggatggcc atatggtagt tatggtcaaa ttcgccatct gctgcgattt
     5881 cttcaattcc ttcttctttc aaagcgtgaa tcaagctttc ttgcaccatc cccaagccct
     5941 tcttcacatc atctgtcaaa ccttcaactg caagtgcacg ctcaaggttg tcaagagatg
     6001 gtaagattgc ttttgccaag tcctggctac gataacgttg caagttttga cgttcttcat
     6061 tggcacggcg ttggatattt tgcatttctg catgagcgcg aagatatttg ttttcgaact
     6121 catctgcacg ttcatttgcc aagtccaact cagacttttc aggagttgtt tcttcagctg
     6181 tttccacaac ttcctcttct tgaacttctt ctacttcttc attttttata tcttgggcca
     6241 tgttcgcctc ctttaatgat ttcaatctta atgtacttcg taatgattac tgctgaggta
     6301 gcggtaaaaa tctgtcaact tcatggtcaa aacacggttg accacattga tttgattgat
     6361 tagctgttgg taatccagat taactggacc gataatggct agaattccaa ctccccgata
     6421 aggaatgagg aacttactac taatcaccgc taggtcagct aaacaggact cttgaccgtc
     6481 tgcaatacga acattttgca tctgatcctc acgcaacccc tcacgaatct ccaaggccac
     6541 cttttgcggt tggtcaaaga actgataggc tgctagattg gcaaaattca agagattgac
     6601 cttgcccgcc atcacaatgt tttcgttgaa catttcctta aagatgtgtt caaagagatc
     6661 gatgacatta tccgttgttg taaagtaacg ctggataatc tgcggaatct ccgtccgaat
     6721 cttgtagtga atatctaaaa cggtgtgacc gaggaaacgt tcctgaatga tgctcttcag
     6781 tttcagcaaa tcctcctgca agaagttcct tggaatcaga aactgactag taaccgttcg
     6841 cgactcgtct agggtaaata ccgccaaggc tgtatgttgc cccaaaacaa cgatatcaaa
     6901 ggctgtcaaa cgttgcctgc tcggctcaac atccagtgcc actaccgt
//
LOCUS       DBMVGT010000077         6840 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.077, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000077 DBMVGT010000000
VERSION     DBMVGT010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6840)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6840)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6840
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.077"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..346)
                     /locus_tag="AC0DU4_001828"
     CDS             complement(<1..346)
                     /locus_tag="AC0DU4_001828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HIN4237749.1"
                     /translation="MIFDTHTHLNVEEFAGREAEEIALAAEMGVIQMNIVGFDKPMIE
                     RALELVDEYEQLYATIGWHPTEAGTYTEEVEAYLLDKLKHPKVVALGEIGLDYHWMTA
                     PKEVQEQVFRRQI"
     gene            complement(651..1622)
                     /locus_tag="AC0DU4_001829"
                     /pseudo
     CDS             complement(651..1622)
                     /locus_tag="AC0DU4_001829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_367670414.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1542 domain-containing protein"
     gene            complement(1828..1962)
                     /gene="rpmH"
                     /locus_tag="AC0DU4_001830"
     CDS             complement(1828..1962)
                     /gene="rpmH"
                     /locus_tag="AC0DU4_001830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA];
                     GO_component: GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HIN4237750.1"
                     /translation="MKRTYQPSKLRRARKHGFRNRMSTKNGRRVLAARRRKGRKVLAA
                     "
     gene            complement(2107..3321)
                     /locus_tag="AC0DU4_001831"
     CDS             complement(2107..3321)
                     /locus_tag="AC0DU4_001831"
                     /EC_number="2.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HIN4237751.1"
                     /translation="MKEYNKSSKLEHVAYDIRGPVLEEAMRMRANGEKILRLNTGNPA
                     EFGFTAPDEVIHDLIMNARDSEGYSDSKGIFSARKAIMQYCQMKKFPNVDIDDIYLGN
                     GVSELIVMSMQGLLDNGDEVLVPMPDYPLWTAAVSLAGGNAVHYICDEAVEWYPDIDD
                     IKSKITSNTKAIVLINPNNPTGALYPKELLLEIIEIARQNDLIIFADEIYDRMVMDGH
                     VHTPVASLAPDVFCVSMNGLSKSHRIAGFRVGWMVLSGPKTHVKGYIEGLNMLSNMRL
                     CSNVLAQQVVQTSLGGHQSVDELLLPGGRIYEQRNFIYNAIQDIPGLSAVKPKAGLYI
                     FPKIDRNMYRIDDDEQFVLDFLKQEKVLLVHGRGFNWQEPDHFRIVYLPRVDELAQIQ
                     EKMTRFLKQYRR"
     gene            complement(3477..3770)
                     /locus_tag="AC0DU4_001832"
     CDS             complement(3477..3770)
                     /locus_tag="AC0DU4_001832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237752.1"
                     /translation="MMKNSFQKSNFLYYGIILVSVLVKVIMICQLESLVPLLYPSFIG
                     FLVFHVLYHLILFLVAKRSGRWDYLMIWGLFLMFNLLYDSFLGLLFLGLSFGM"
     gene            3919..4371
                     /locus_tag="AC0DU4_001833"
     CDS             3919..4371
                     /locus_tag="AC0DU4_001833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042802 - identical protein binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HIN4237753.1"
                     /translation="MAQRYQNIMVAIDGSKEADLAFVKGVHSALRNDAKLTIAHVIDT
                     RALQSVSTFDAEVYEELQVDAESLMKEYEKRAKDAGVADVHIVIEMGNPKTLLARTIP
                     DAEEVDLILVGATGLNAFERLLVGSSSEYILRHAKVDLLVVREQEKTL"
     gene            complement(4406..5794)
                     /locus_tag="AC0DU4_001834"
     CDS             complement(4406..5794)
                     /locus_tag="AC0DU4_001834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000453140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HIN4237754.1"
                     /translation="MEVKAVFFDIDGTLVNNRKSVLKSTKDAIKIVKEQGVLVGVATG
                     RGPFFVKELMDDLDLDFAVTYNGQYIFSKDRVLFTSPISKLHLRHLISYAKKEGTEIA
                     LGTKDAMLGSKIMSFGLGSFSQRISRFVPSVLTRTVSQSFNRMVSKVVPQKEEDLLHL
                     MNQPIYQVLMLMTPEESEKAAADFEDLKLTRSNPFASDVINQGNSKLEGIRRVGKEYG
                     FDLNQVMAFGDSDNDLEMLAGVGMSVAMGNGSSSVKEAAKHITTSNQQDGIHKALEHF
                     GVLSSEKVFVSRDYHFNKVKTFHHMMDERTQEEPRAWDLEGATHRAGFKIEELVEFVR
                     AASPSEEDFGQAVSQLHQALDKAAGKVAKKTPAQQDLIGQVDALIDTLYFTYGSFVLM
                     GVDPERIFDIVHQANMGKIFPDGKAHFDPVTHKILKPDNWEEKYAPEPAIKKELHRQL
                     KAYERHKERNKS"
     gene            5860..6822
                     /locus_tag="AC0DU4_001835"
     CDS             5860..6822
                     /locus_tag="AC0DU4_001835"
                     /EC_number="3.5.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004067 - asparaginase activity [Evidence
                     IEA];
                     GO_process: GO:0006528 - asparagine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HIN4237755.1"
                     /translation="MPKKILVLHTGGTISMQADASGAVVTSSDNPMNHVSNPLEGIQV
                     HALDFFNLPSPHIKPKHMLVLYQKIKEEADNYDGVVITHGTDTLEETAYFLDTMEVPH
                     MPIVLTGAMRSSNELGSDGVYNYLSALRVASDDRAADKGVLVVMNDEIHAAKYVTKTH
                     TTNVSTFQTPTHGPLGLTMKQEILYFKTAEPRVRFDLDHIQGLVPIISAYAGMTDELI
                     DMLDLEHLDGLIIQAFGAGNIPKETAQKLESLLQKGIPVALVSRCFNGIAEPVYAYQG
                     GGVQLQKAGVFFVKELNAQKARLKLLIALNAGLTGQALKDYMEG"
BASE COUNT         1920 a         1585 c         1301 g         2034 t
ORIGIN      
        1 gaatctgacg gcgaaaaacc tgctcctgca cctctttggg cgctgtcatc caatggtaat
       61 ctaagccaat ttcacctaaa gccacaacct tgggatgttt taacttatcc aacaagtaag
      121 cctcaacttc ctctgtataa gtaccagctt ctgtaggatg ccaaccaata gtcgcataga
      181 gctgctcata ctcatctacc aactccaagg cacgctcaat catcggttta tcaaaaccaa
      241 caatattcat ctgtatcaca cccatctcag cagccaaggc aatttcttct gcctcacgac
      301 ctgcaaattc ttctacattc aagtgtgtat gtgtatcaaa aatcatctct tctaacctcg
      361 ttttctatct tctattatac caaaaaagag gaggggcacc taatttttcg gtttcccctc
      421 ctctcttcaa tagagagcta ttctgctatc ttttctatcc gatattgccc atctcctatt
      481 ccacagttag agacagaaga gattggctac attgatagaa tattcctatt cagctaaagt
      541 atgtgattat cttgggttct cacttttctc acccatcact aggattgatg acttctcaaa
      601 atccccctta taatctaact ttaagtagag aatagaattt tctagctgtt ctattttcta
      661 cgtctagtct ttcttcctag caaagcaaaa ccacttgttg ccaccactag accaagacta
      721 gcaagtgctg cacttgatgc tgaacctgtg ttaggtaatt gtttgccagc aggtgactgg
      781 taggtaacat cttgcattgt tcctgcagtt gcttgcggtg cacttgttgt cttaggagca
      841 gcattaggag ccactagtct cttaggaact gtaaccatgg caatggcttg cactccaatc
      901 gtttctgctt ccttcacatc ttccatagtt ttcgcatttt caatctcttt gagagctgct
      961 tgtttttctg cttccactct tgctaaaagt tctgcttttt ctttatcaga aagcggtgcg
     1021 cctttgattt catcctgctt gtccttggct gctttttcaa tggcattttt agctgattct
     1081 ttttcagtag ctaattgctt agaagcttgt gattgagctg agttttgtga acctgtgtga
     1141 gctgatccac ccgcctggct accaccgcct tcattcgcat tagcatctga gcttccaata
     1201 ttgcctccct tatctccacc tggtgtagtt tctagcttat actctggtgt aacttcttga
     1261 gttacagatt cacctttcgc agattgttga actgtatctt ttcctagaat cgtcactact
     1321 gaaccatctg ggaatgtgat tgttgctgta ccatctccag ctacattgat tgtcgctccg
     1381 tctaatgctg aaccatttgc ttgtaaaata gcaaccttaa ctttttcttc atctgttaaa
     1441 tgagttatat cttttacatc tactctttga gcaggtgctt taacagttga tttttcagca
     1501 gtcggtttag tgctatcttg tgcttttgga tcttgtgcta ccaattgatt tcctggaatt
     1561 gtaatagctg aaccatcttt aaagacgatt gttgctgtac catctccacc tacttcaact
     1621 ttatagtaaa ataaaataat aacaggacaa atcgatcagg acagtcaaat cgatttctaa
     1681 caatgtttta gaaacagagg tgtactattc tagtttcaat ctactataac atcgcttccg
     1741 aatccatttg catctactga acttttttac aaaaataaaa atcagtagac tcgagttcct
     1801 actgattttt gatagaattc gtttggatta tgcagccaaa actttgcgtc ctttacgacg
     1861 acgagctgcc aatacgcgac gaccattttt agttgacata cggttacgga atccgtgttt
     1921 gcgcgcacga cgaagtttac ttggttgata agtacgtttc acgatgaata cctcctcata
     1981 gattttgtat tcgtttagcc ggctataaag tgatcagtta ctaaacatac tttactattc
     2041 tatctgattc tttcactttt gtcaatagct ctaggcaaat gtttccagct ttttcgaatg
     2101 caagccctat ctacgatact gtttcaagaa acgagtcatc ttttcttgga tttgggctaa
     2161 ctcatcaaca cgaggaaggt aaacgatacg gaagtggtct ggttcctgcc agttaaagcc
     2221 tcgaccatga accaagagaa ccttttcctg cttcaagaaa tcaaggacaa actgctcatc
     2281 atcatcgata cggtacatat tgcggtcgat ttttgggaag atatagagcc ccgccttggg
     2341 tttaacggca gacaaacctg gaatatcttg aatggcatta tagatgaaat ttctttgctc
     2401 gtagattcgt ccaccaggaa gaagtaattc atcgactgat tggtgacccc ccaaggaagt
     2461 ttgtacgact tgttgggcca aaacgttaga gcaaaggcgc atattggaca gcatattgag
     2521 cccttcgata tagcccttaa catgagtctt agggccagac aagaccatcc aacccacacg
     2581 gaaacctgct atgcggtggg attttgacag accattcatg ctgacacaga agacatctgg
     2641 tgccaagctc gccacaggcg tatgcacatg tccgtccatt accatgcggt catagatttc
     2701 atccgcaaag ataatcaaat cgttttgacg ggcaatctca ataatctcca gcaagagttc
     2761 cttaggataa agggctccag ttgggttatt tggattgata aggacgattg ccttggtatt
     2821 ggaagtgatt tttgacttga tatcgtcaat atctgggtac cattcaacag cttcatcaca
     2881 gatatagtga acggcatttc ctccagctag gctgacagcc gccgtccata gaggatagtc
     2941 tggcattggc actaagacct catccccatt gtccaaaagc ccctgcatgg acatgacaat
     3001 caactcactg acaccatttc caaggtaaat atcatcaata tctacgtttg ggaatttctt
     3061 catctggcaa tactgcatga tggccttacg ggctgagaaa atccctttgg agtcagaata
     3121 gccttcacta tcacgcgcat tcataatcaa gtcatgaatg acctcgtctg gcgctgtaaa
     3181 gccaaattct gctggatttc ctgtattcag acgtaaaatc ttttctccat tcgctcgcat
     3241 ccgcatggct tcttccaata caggaccacg gatatcataa gcaacatgct ctaacttact
     3301 agacttgtta tattctttca tcttgtttcc tcaattcatc aggatagtaa cattatacca
     3361 ctagaaagag aatgcgacaa gtttactgaa atgtgttact agtttcgtat agaagaaaaa
     3421 ccttgctaaa ggcgaggtta agaacgtaga gatagcaggt attttgcaaa gacacatcac
     3481 ataccaaaag ataaacctag aaaaagcaag cctagaaagg agtcataaag aagattaaac
     3541 atgaggaaaa gcccccatat catcaagtaa tcccaacgcc cacttcgttt tgcaactaga
     3601 aataagatta gatggtagag tacatgaaag actaaaaatc caataaaact tggataaaga
     3661 agcggtacca gactctctaa ttgacagatc atgatcactt ttaccaagac tgaaactagg
     3721 ataattccat aataaaggaa atttgatttt tgaaaagagt ttttcatcat tctcctttcc
     3781 tcctatcctt tcttttattt tatcatatat ttatatagag tttaagccct aatattcttt
     3841 tgaaaaatac tttttttgct ttacttctat agtgaaaagg tttacaatta tagtaagaaa
     3901 atttcaggag gtttcattat ggcacaacgt taccaaaata tcatggtcgc aatcgatggt
     3961 tctaaggaag cggacttggc ttttgtcaag ggagttcatt ctgctctacg aaacgacgct
     4021 aaactcacca tcgcacatgt cattgacaca cgcgctctcc aaagcgtatc cacctttgat
     4081 gctgaagttt acgaagaact ccaagtcgac gctgaaagtc tgatgaaaga gtacgaaaaa
     4141 cgtgctaaag atgctggggt agcagatgtt catatcgtca ttgaaatggg aaatccaaag
     4201 accctgctag cacgtactat tccagatgcc gaggaagtgg acctcatcct cgtgggcgca
     4261 actggtctca acgcctttga acgcctcttg gtcggctctt catctgaata catactccgc
     4321 catgctaagg tcgatttgct ggttgtgaga gaacaagaaa aaaccttata atcacaaaga
     4381 aaaggagccc ctagctcctt tttgtttacg atttatttct ctctttatgg cgttcgtaag
     4441 ccttgagctg gcgatgcagt tcctttttaa tagcaggttc tggagcatat ttttcttccc
     4501 aattatctgg ttttaagatt ttatgggtca ctggatcaaa atgagccttg ccatctggaa
     4561 aaattttccc catattggcc tgatggacaa tatcaaaaat acgttctggg tccaccccca
     4621 tcaagacaaa actgccgtag gtgaagtaaa gcgtgtcaat caaggcatcc acttgcccta
     4681 tcaaatcttg ctgagcaggt gtcttcttgg ctactttacc tgctgcctta tcaagggcct
     4741 gatgaagttg cgatacagct tgaccaaaat cttcttcaga aggactggct gctcgaacaa
     4801 actccaccaa ttcttctatt ttaaaaccag ccctatgggt tgcaccctct aaatcccaag
     4861 ctcgaggttc ttcttgggtt cgttcatcca tcatgtggtg gaaggtcttg accttattga
     4921 aatgatagtc acggctgaca aagacttttt ctgaagacaa aacaccaaaa tgttccaagg
     4981 ccttgtggat cccatcttgt tgattgctag tggtaatgtg cttggcagct tccttgacac
     5041 tgctactacc atttcccata gcgaccgaca taccgacgcc agccagcatt tcaaggtcat
     5101 tatctgagtc accaaaagcc atgacttggt tgaggtcaaa gccatattct ttcccaactc
     5161 ggcgaatgcc ttctaattta gaatttccct gattgatgac atccgatgca aaaggattgc
     5221 tacgtgtcaa tttcaagtct tcaaaatcag ctgccgcctt ctcagattct tctggtgtca
     5281 tcagcatcaa aacttggtag ataggctgat tcatcaggtg aagcaggtcc tcttcctttt
     5341 ggggaacaac cttgctgacc atgcgattaa aagactgact caccgtccga gttaaaacag
     5401 agggaacgaa gcgactaatt cgttgggaaa aagaacccag accaaaggac atgattttag
     5461 aacccaacat ggcatccttg gtccctagag caatctccgt gccctctttt ttagcatagc
     5521 taattagatg gcgcaaatgt aacttggaaa tagggctcgt gaacaagact ctgtctttac
     5581 taaagatata ctggccatta taggttaccg caaaatccag atccaaatcg tccatcaatt
     5641 ccttaacaaa aaaaggtcct cgccctgtcg ctacgccaac tagtacccct tgttctttga
     5701 caatcttaat cgcgtcctta gtggatttca aaacactctt gcgattgttg accaaggttc
     5761 catcgatatc aaaaaaaaca gctttgactt ccatcctatt ccaatctccc cttttgtgat
     5821 acaatgatta taccacattt cagaaagagt gagtaaatca tgcctaagaa aatccttgtt
     5881 ttacatacgg gtggaactat ttccatgcag gccgatgctt ctggcgctgt tgtgacgagt
     5941 tcagataatc ccatgaacca tgtgtccaac ccacttgaag gaatccaagt ccacgccttg
     6001 gactttttta accttccaag tccccatatc aaacccaaac atatgctggt cctctaccag
     6061 aaaattaaag aggaagcaga taactacgat ggagtggtga tcacacacgg aaccgatact
     6121 ttagaggaaa cagcctattt ccttgatacc atggaagttc cccatatgcc tatcgttcta
     6181 acaggagcca tgcgtagctc caatgagctc ggtagtgatg gtgtttataa ttacctaagt
     6241 gctttacgag tggccagcga tgacagggct gctgacaaag gagttttggt cgttatgaac
     6301 gatgaaatcc acgctgccaa gtatgtcacc aaaacacata cgactaatgt cagcaccttc
     6361 cagactccaa cacatggccc cctcggtctc accatgaaac aggaaatcct ctacttcaaa
     6421 acagctgaac ctcgtgttcg ctttgacctt gatcacatac aaggtttagt ccctatcatc
     6481 tcggcttatg ctggtatgac agatgagctg attgatatgc tggatttaga acacttggac
     6541 ggtttgatta tccaagcctt cggagctggt aatattccca aagaaacggc tcaaaaatta
     6601 gaaagccttc tgcaaaaagg aattccagtc gctctggtat cacgatgctt taacggtatt
     6661 gccgagcctg tttatgccta ccagggtggg ggcgtacagt tgcaaaaagc aggcgttttc
     6721 tttgttaaag aactcaacgc ccaaaaagct cgcttgaaac tcctcatcgc cctcaatgcc
     6781 ggactaacag gacaggcttt gaaagactat atggaaggct aatactcttc gaaaatctct
//
LOCUS       DBMVGT010000078         6781 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.078, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000078 DBMVGT010000000
VERSION     DBMVGT010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6781)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6781)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6781
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.078"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..372
                     /locus_tag="AC0DU4_001836"
     CDS             <1..372
                     /locus_tag="AC0DU4_001836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IS630-like element IS630-Spn1 family
                     transposase"
                     /protein_id="HIN4237756.1"
                     /translation="KVSGRRYQRISLVAGLTNGELIAPMTYEETMTSDFFEAWFQNFL
                     LPTLTTPSVIIMDNVRFHRMGKLELLCEEFGHKLLPLPPYSPEYNPIEKTWAHIKKHL
                     KKVLPSCNTFYEALLSCSCFN"
     gene            433..1395
                     /locus_tag="AC0DU4_001837"
     CDS             433..1395
                     /locus_tag="AC0DU4_001837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237757.1"
                     /translation="MNMSNITIDGQEMDLSQTMPSYAQVVSLYEDTSISVSSNETDKV
                     LAGSLYTDTNEQGLMIPSSLLKNWNEQTGKNLTANDLIGKSVSASIVESAAEASKIAQ
                     FQTKIVRVINDEDDMEDSNSFMLSHQMETILKEAGFTKAVSYFILELKDPSQTKVVTE
                     ELQKNKKYTVLSQQRVLDIVITFIRVIQGLLIVLSSQAIVVAAVMIGIIIYINIMQRS
                     KEIGVMKAVGYQNRGVKGIFIYEAIWIVGIALLLAFLVAQGVGSLANAIVSHFYPSIT
                     KVFELNLLSVLGTLVFALLLGYVSAYFPARKISKMDPVESLRYE"
     gene            1572..2579
                     /gene="gap"
                     /locus_tag="AC0DU4_001838"
     CDS             1572..2579
                     /gene="gap"
                     /locus_tag="AC0DU4_001838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008090210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA];
                     GO_function: GO:0050661 - NADP binding [Evidence IEA];
                     GO_function: GO:0051287 - NAD binding [Evidence IEA];
                     GO_process: GO:0006006 - glucose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HIN4237758.1"
                     /translation="MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHL
                     LKYDTTQGRFDGTVEVKEGGFEVNGKFIKVSAERDPEQIDWATDGVEIVLEATGFFAK
                     KEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
                     KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIG
                     LVIPELNGKLDGSAQRVPTPTGSVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDP
                     IVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIA
                     K"
     gene            complement(2647..3522)
                     /locus_tag="AC0DU4_001839"
     CDS             complement(2647..3522)
                     /locus_tag="AC0DU4_001839"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HIN4237759.1"
                     /translation="MQFTFTLPASLPQMTVKQLLEEQLLIPRKIRHFLRIKKHILINQ
                     EEVRWNEIVNPGDVCQLTFDEEDYPQKTIPWGNPDLVQEVYQDQHLIIVNKPEGMKTH
                     GNQPNEIALLNHVSTYVGQTCYVVHRLDMETSGLVLFAKNPFILPILNRLLEKKEISR
                     EYWALVDGNINRKELVFRDKIGRDRHDRRKRIVDAKNGQYAETHVSRLKQFSNKTSLA
                     HCKLKTGRTHQIRVHLLHHNLPILGDPLYNSKSKTSRLMLHAFRLSFTHPLTLERLTF
                     TTLSNTFEKELKKNG"
     gene            3609..5804
                     /gene="pbp2a"
                     /locus_tag="AC0DU4_001840"
     CDS             3609..5804
                     /gene="pbp2a"
                     /locus_tag="AC0DU4_001840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein PBP2A"
                     /protein_id="HIN4237760.1"
                     /translation="MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGP
                     IRKFWRRYHLTKIILILGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKE
                     AGALSGQKGTYVELTDISKNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGS
                     TITQQLAKNAYLSQDQTVERKAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVE
                     DASKKYFGVSASEVSLDQAATLAGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYI
                     DKNQETEAAEVDMTSQLHDKYEGKISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYR
                     IYTELDQNYQANMQIVYENTSLFPRAEDGTFAQSGSVALEPKTGGVRGVVGQVADNDK
                     TGFRNFNYATQSKRSPGSTIKPLVVYTPAVEAGWALNKQLDNHTMQYDSYKVDNYAGI
                     KTSREVPMYQALAESLNLPAVATVNDLGVDKAFEAGEKFGLNMEKVDRVLGVALGSGV
                     ETNPLQMAQAYAAFANEGLMPEAHFISRIENASGQVIANHKNSQKRVIDKSVADKMTS
                     MMLGTFTNGTGISSSPADYVMAGKTGTTEAVFNPEYTSDQWVIGYTPDVVISHWLGFP
                     TTDENHYLAGSTSNGAAHVFRNIANTILPYTPGSTFTVENAYKQNGIAPANTKRQVQT
                     NDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQTIWDSIVNLFR"
     gene            5857..6009
                     /gene="rpmG"
                     /locus_tag="AC0DU4_001841"
     CDS             5857..6009
                     /gene="rpmG"
                     /locus_tag="AC0DU4_001841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HIN4237761.1"
                     /translation="MALKKASLACAVCGSRNYSIKISGNPKPTRLEVNKFCKHCGKYT
                     THRETR"
     gene            6019..6195
                     /gene="secE"
                     /locus_tag="AC0DU4_001842"
     CDS             6019..6195
                     /gene="secE"
                     /locus_tag="AC0DU4_001842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_function: GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA];
                     GO_process: GO:0009306 - protein secretion [Evidence IEA];
                     GO_process: GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HIN4237762.1"
                     /translation="MRFIGDIFRLLKDTTWPTRKESWRDFRSIMEYTAFFVVIIYIFD
                     QLIVSGLIRFINIF"
     gene            6250..>6781
                     /gene="nusG"
                     /locus_tag="AC0DU4_001843"
     CDS             6250..>6781
                     /gene="nusG"
                     /locus_tag="AC0DU4_001843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0032784 - regulation of DNA-templated
                     transcription elongation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusG"
                     /protein_id="HIN4237763.1"
                     /translation="MDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIP
                     TQTVQVEKNGKRKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPT
                     PLLEQEIRDILVSMGQTVQEFDFDVEIGQTVRIIDGAFADYTGKITEIDNNKVKMIIS
                     MFGNDTVAEVNLNQIAE"
BASE COUNT         2103 a         1191 c         1469 g         2018 t
ORIGIN      
        1 aaagtatctg gaagaagata tcagaggatt tctttggttg caggtctaac aaatggtgaa
       61 ttaatcgctc caatgactta cgaagagacg atgacgagcg acttttttga agcttggttt
      121 cagaattttc tcttaccaac attaaccaca ccatcggtta ttattatgga taatgtaaga
      181 ttccatagaa tggggaagct agaactttta tgcgaagagt ttgggcataa actgttacct
      241 cttcctccct actcgcctga gtacaatcct attgagaaaa catgggctca tatcaaaaag
      301 cacctcaaaa aggtattacc aagttgcaat accttttacg aggctctttt gtcttgttct
      361 tgtttcaatt gactatagtt cacggataca gttgggaaag aagctattaa ttatttggag
      421 agtccttttg ggatgaacat gtcaaatatt actatagatg ggcaagaaat ggatctgagt
      481 caaacgatgc cttcttatgc tcaagtagtg agtctttatg aggatacaag catctctgtt
      541 agtagtaatg agacggacaa agtgttggct ggatccctct atactgatac aaatgaacag
      601 ggattaatga ttccaagcag tttactaaaa aattggaatg aacagacagg aaaaaatttg
      661 acagctaatg atcttattgg caaatcagtc tcagccagca ttgtagaaag tgctgccgaa
      721 gctagtaaga ttgctcaatt tcaaacgaag attgtacgtg taatcaatga tgaagatgac
      781 atggaggaca gcaacagttt catgctgtct catcaaatgg aaacgatttt gaaagaggct
      841 ggatttacga aagctgtatc ttattttatc ttggaactca aagatccatc acagacaaaa
      901 gtagtaacag aagaattaca gaaaaataag aagtatactg tgctttctca acagagagtt
      961 cttgatattg tgattacctt tattcgtgtt attcagggat tattgattgt gctttcatca
     1021 caagctattg tggtagcagc ggttatgatt ggtatcatta tttacatcaa tatcatgcaa
     1081 cgttccaagg aaataggtgt catgaaagca gttggttatc agaatcgtgg tgtcaaagga
     1141 atttttattt acgaggctat ctggattgta ggcatcgcct tgctgctggc atttttggtt
     1201 gcacaagggg tgggaagttt ggcgaatgcg attgtaagtc acttttaccc atccatcact
     1261 aaggtttttg aattaaatct tttatctgtt ttaggaactc tagttttcgc tctattactt
     1321 ggttatgtct cagcctactt cccggcgcgt aagattagta aaatggatcc tgtagaatcg
     1381 ttacgctatg aataataagg gattccttga tttacagtct taaaaagaaa ctcacataga
     1441 aaaacaatgg ccatacttgc aattcaactc aaatagttgt ataataggtt tgttgaaagg
     1501 tgatttgtag tgattcaagt tactcttttc acaataaaaa tttcatgatt ttcataagga
     1561 ggaaatcact aatggtagtt aaagttggta ttaacggttt cggacgtatc ggtcgtcttg
     1621 ctttccgtcg tatccaaaac gtagaaggtg ttgaagttac acgcatcaac gaccttacag
     1681 atccagttat gcttgcacac ttgttgaaat acgacacaac tcaaggtcgt ttcgacggta
     1741 ctgttgaagt taaagaaggt ggatttgaag ttaacggtaa attcatcaaa gtttctgctg
     1801 aacgtgatcc agaacaaatc gactgggcta ctgacggtgt agaaatcgtt cttgaagcta
     1861 ctggtttctt tgctaagaaa gaagcagctg aaaaacacct taaaggtgga gctaaaaaag
     1921 ttgttatcac tgctcctggt ggaaacgacg ttaaaacagt tgtattcaac actaaccacg
     1981 acgttcttga cggtactgaa acagttatct caggtgcttc atgtactaca aactgcttgg
     2041 ctccaatggc taaagctctt caagacaact ttggtgttgt tgaaggattg atgactacta
     2101 tccacgctta cactggtgac caaatgatcc ttgacggacc acaccgtggt ggtgaccttc
     2161 gccgtgctcg cgctggtgct gcaaacatcg ttcctaactc aactggtgct gcaaaagcta
     2221 tcggtcttgt aatcccagaa ttgaatggta aacttgatgg atctgcacaa cgcgttccaa
     2281 ctccaactgg atcagttact gaattggtag cagttcttga aaagaacgtt actgttgatg
     2341 aagtgaacgc agctatgaaa gcagcttcaa acgaatcata cggttacaca gaagatccaa
     2401 tcgtatcttc agatatcgta ggtatgtctt acggttcatt atttgacgca actcaaacta
     2461 aagttcttga cgttgacggt aaacaattgg ttaaagttgt atcatggtac gacaacgaaa
     2521 tgtcatacac tgcacaactt gttcgtactc ttgaatactt cgcaaagatt gctaaataat
     2581 tcttgagttg atagaaagca aggctttgtg gtcttgcttt tttatatgga aaaatggatg
     2641 acacgatcat ccattctttt ttaattcttt ttcaaatgta tttgaaaggg tagtgaaagt
     2701 tagcctctct aaagtaagtg ggtgggtaaa ggaaagtcgg aaggcatgaa gcataagccg
     2761 gcttgtcttt gatttactat tatagagagg gtctcccagg ataggaagat tatgatgcaa
     2821 aaggtgcaca cgaatctgat gggttcgccc tgtctttagc ttgcaatgag ccaaggaagt
     2881 cttgtttgag aattgcttta atctgcttac atgcgtttca gcatattgcc cattttttgc
     2941 atcaactatt ctttttctac gatcatggcg atcacgtcca attttgtctc tgaaaacaag
     3001 ttcttttctg ttgatatttc catcaactag agcccaatat tctctagaaa tctctttttt
     3061 ctccaataag cgattgagaa tgggcaggat aaaaggattt ttggcaaaga gaactaagcc
     3121 actggtttcc atgtccagac gatgaacgac atagcaggtt tggccaacat aggtactgac
     3181 atggttaaga agggcaattt cgtttggttg attaccatgc gttttcatcc cctctggttt
     3241 gtttacaata atcaagtgtt gatcttgata aacttcctgc actaagtctg ggttgcccca
     3301 agggatcgtc ttttggggat aatcttcctc gtcaaaagtc aactggcaaa catctccagg
     3361 atttacgatt tcgttccagc ggacttcttc ttgatttatc aaaatatgtt tcttgattct
     3421 caaaaaatga cggatttttc tagggatgag gagttgttcc tcaagtaatt gctttaccgt
     3481 catttgaggt agagaggcgg gtaatgtaaa tgtgaattgc atacagatat tgtaacaaaa
     3541 aaagccctat ttggatagga aatagctaaa ttcttgtctt cctatgatga agatgataaa
     3601 ataaacgcat gaaattagat aaattatttg agaaatttct ttctcttttt aaaaaagaaa
     3661 caagtgaact agaggactct gattctacta tcttacgtcg ctctcgtagt gatcgaaaaa
     3721 aattagccca agtaggtccg attcgaaaat tctggcgtcg ttatcatcta acaaagatta
     3781 tccttatact aggtttgagt gcaggcttgc tagttggaat ctatttgttt gctgtagcca
     3841 agtcgaccaa tgtcaatgat ttgcaaaatg ccttgaaaac tcggactctt atttttgacc
     3901 gtgaagaaaa agaggctggt gccttgtctg gtcaaaaggg aacctatgtt gagctgactg
     3961 acatcagtaa aaacttgcag aatgctgtta ttgcgacaga agaccgttct ttctataaaa
     4021 atgacgggat taactatggc cgtttcttct tggctattgt cactgctgga cgttcaggtg
     4081 gtggctctac cattacccaa cagctggcta aaaacgccta tttatcgcag gatcaaactg
     4141 ttgagagaaa agcgaaagaa tttttccttg ccttagaatt aagcaaaaaa tatagtaagg
     4201 agcaaattct aaccatgtac cttaacaacg cttattttgg aaatggtgtg tggggtgtag
     4261 aagatgcgag taagaaatac tttggagttt ctgcatcaga agtgagtctg gatcaagctg
     4321 cgactctggc agggatgctc aaggggccgg aactgtataa tcccttgaat tccgtagaag
     4381 attctactaa tcggcgcgat actgtcttgc agaatatggt tgcagcagga tatattgata
     4441 aaaaccaaga aaccgaagct gctgaagttg atatgacttc gcaattgcac gataagtatg
     4501 aaggaaaaat ctcagattac cgttacccct cttattttga tgcggtggtt aatgaagctg
     4561 tttccaagta taatctaaca gaggaagaga ttgtcaataa tggctaccgc atttacacag
     4621 agctggacca aaactaccaa gcaaatatgc agattgttta tgaaaacaca tcgctatttc
     4681 cgagggcaga ggatggaacg tttgctcaat caggaagtgt agctctcgaa ccgaaaacag
     4741 ggggagttcg tggagttgtc ggtcaagttg ctgacaatga taaaactgga ttccggaatt
     4801 tcaactatgc aacccaatca aagcgtagtc ctggttctac aattaagcct ttagttgttt
     4861 atacgccagc agttgaagca ggctgggctt tgaataagca gttggataac cataccatgc
     4921 agtatgacag ctataaggtt gataactatg cagggatcaa aacgagtcga gaagttccta
     4981 tgtatcaagc cttggcagaa tcgcttaatc tacctgctgt tgccactgtt aatgatttgg
     5041 gtgtcgacaa ggcttttgag gcaggcgaaa aattcggact caacatggaa aaggtcgacc
     5101 gtgttcttgg tgtcgccttg ggaagcggtg ttgaaaccaa ccctcttcaa atggctcaag
     5161 catacgctgc ctttgcaaat gaaggtttaa tgcctgaagc tcattttatt agtagaattg
     5221 aaaatgctag tggacaagtt attgcgaatc ataaaaattc acaaaaacgg gtgattgata
     5281 agtctgtagc tgacaagatg accagtatga tgttggggac tttcaccaac ggtaccggta
     5341 ttagttcatc gcctgcagac tatgtcatgg cagggaaaac tggaacaact gaagcagttt
     5401 tcaatccgga gtacacaagt gaccagtggg taattggtta tactccggat gtagtgatta
     5461 gccactggct tggctttccg accactgatg aaaatcacta tctagctggc tctacttcaa
     5521 acggtgcagc tcatgtcttt agaaacattg ccaataccat tttaccttat acgccaggaa
     5581 gtacctttac ggttgaaaat gcttataagc aaaatggaat tgcaccagcc aatacaaaaa
     5641 gacaagtaca aaccaatgat aatagccaga cagatgataa tttgtctgat attcgagggc
     5701 gtgcgcaaag tctagtagat gaggctagcc gggctatctc agatgcgaag attaaggaaa
     5761 aggctcaaac aatatgggat tcgatagtca atctatttcg ctaagatgct tgtcaaagcc
     5821 tagctttctt gttataatgg ataagatgga ggcgttatgg cactaaaaaa agcaagccta
     5881 gcttgtgcgg tttgtggttc gagaaactat tcaatcaaga tcagcggaaa ccccaagcct
     5941 acacgactag aagtaaataa attttgtaag cattgtggca agtacactac acacagagaa
     6001 acgagatagg agagagcgat gcgttttatt ggagatattt ttagacttct taaagacaca
     6061 acatggccaa ctcgcaagga aagctggaga gattttcgtt ctatcatgga atacacagct
     6121 ttctttgtag taattattta catttttgac cagttgattg tttcaggttt gattcgattt
     6181 attaacattt tttagaagat tagtggagtt aattacacta gaaatcttct atttatgaaa
     6241 ggaaatatca tggatagttt tgataaagga tggtttgttt tacaaactta ttctggttat
     6301 gaaaataagg tgaaagaaaa tctattacaa cgtgcacaaa cctacaatat gttggataat
     6361 attctacgcg ttgaaattcc aacacaaaca gtgcaagttg aaaaaaatgg aaagagaaaa
     6421 gaagtagaag aaaatcgctt tccaggttat gttcttgtag aaatggtcat gacagatgaa
     6481 gcttggtttg ttgttcgaaa cacaccaaat gttacaggat ttgtcggatc acacgggaac
     6541 agatcaaaac caactccatt attggaacaa gaaattcgtg acattttggt atctatggga
     6601 caaactgttc aagaatttga tttcgatgtt gagattggtc aaactgtacg tattattgat
     6661 ggtgcttttg cagactacac tggtaagatt acagaaattg ataataacaa agtgaaaatg
     6721 attatctcta tgtttggtaa tgacacagtt gcagaagtaa acctaaacca aatcgcagaa
     6781 t
//
LOCUS       DBMVGT010000079         6766 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.079, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000079 DBMVGT010000000
VERSION     DBMVGT010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6766)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6766)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6766
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.079"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            20..883
                     /locus_tag="AC0DU4_001844"
     CDS             20..883
                     /locus_tag="AC0DU4_001844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237764.1"
                     /translation="MRYDFGKVYKEIRESKGLTQEEVCGGVLSRTSLSKIESGKTTPK
                     YENMEFLLRQINMSFEEFEYICQLYQPSQRTEIMQTYLNMRSIIGTSDLVNLFQKCQD
                     YLKTHHDLPIEEIRDMLEVVIYIRQHGAGELSDHAEQVVKKLWRKIEKQDTWYESDLK
                     ILNTILFSFPIEYLHLITGKILQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMC
                     KQICYTLLEDAKNKKSYDRLAICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKK
                     EVEIYYQAKER"
     gene            complement(1096..1488)
                     /locus_tag="AC0DU4_001845"
                     /pseudo
     CDS             complement(1096..1488)
                     /locus_tag="AC0DU4_001845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269502.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004055 - argininosuccinate synthase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006526 - L-arginine biosynthetic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate synthase domain-containing
                     protein"
     gene            complement(1505..2311)
                     /locus_tag="AC0DU4_001846"
     CDS             complement(1505..2311)
                     /locus_tag="AC0DU4_001846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4237765.1"
                     /translation="MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVAL
                     NPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKAD
                     LAISGVSKTDERSKVFDFSIPYYTAKNKLIVKKSDLTTYQSVNDLAQKKVGAQKGSIQ
                     ETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVSKGFVENNPDLAIADLNF
                     EKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK"
     gene            complement(2518..3159)
                     /locus_tag="AC0DU4_001847"
     CDS             complement(2518..3159)
                     /locus_tag="AC0DU4_001847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237766.1"
                     /translation="MIELKNITKTIGGKVILDNLSLRIDQGDLVAIVGKSGSGKSTLL
                     NLLGLIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLML
                     ALKYVKLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLIL
                     ADEPTGSLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRVIELGEGK"
     gene            complement(3156..5264)
                     /locus_tag="AC0DU4_001848"
     CDS             complement(3156..5264)
                     /locus_tag="AC0DU4_001848"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000723955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HIN4237767.1"
                     /translation="MKKISNFCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDL
                     YLKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLD
                     FTTDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEM
                     DKDRIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQP
                     MMEMKRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPML
                     WLSHFLLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLIFNYVMKIGTTILLTAL
                     LIGVGRSLEQENKELAYQQQWVSQGNYLTLETFKLNDNLWQEELAGSGKSTDYFYRFY
                     QDLVEKTQAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTG
                     IKKVILMPASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFP
                     YSDKRKENLSNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKL
                     SDGNYLKFSSIQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRD
                     IITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVL
                     GLASRMEKRSLVELLKGGIL"
     gene            complement(5316..5603)
                     /locus_tag="AC0DU4_001849"
     CDS             complement(5316..5603)
                     /locus_tag="AC0DU4_001849"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001230165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HIN4237768.1"
                     /translation="MRKLVKIGVASLMVCGILATTNALAVWVEGGQWNYGVGWTGTFG
                     YSDYLHSTRYHTATVRHGGRTSKDYAKPEAWARASLTKIPPTGMEYFYGFE"
     gene            6021..6347
                     /locus_tag="AC0DU4_001850"
                     /pseudo
     CDS             6021..6347
                     /locus_tag="AC0DU4_001850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268160.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
     gene            complement(6399..>6766)
                     /locus_tag="AC0DU4_001851"
     CDS             complement(6399..>6766)
                     /locus_tag="AC0DU4_001851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="peptidoglycan-binding protein LysM"
                     /protein_id="HIN4237769.1"
                     /translation="LVIDGPVAPVATPAPATYAAPAAQDETVSAPVAETPVVSETVVS
                     TVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNGDYSAENQERVADAYVA
                     GRYGSWTAAKNFWLNNGWY"
BASE COUNT         2126 a         1480 c         1129 g         2031 t
ORIGIN      
        1 tcacagaaag gagaaaatca tgcgttatga tttcggaaag gtctataaag aaatacgtga
       61 gtcaaagggg ctgacccaag aagaggtctg tgggggtgtt ctctcaagaa ccagcttatc
      121 aaaaatcgaa agtggcaaga caaccccaaa atatgaaaat atggaatttc ttctccgtca
      181 aatcaatatg agttttgaag agtttgaata tatctgtcaa ctttatcaac caagtcaacg
      241 cacagagatt atgcaaacct atctcaatat gcgttccatt atcgggacca gcgatcttgt
      301 caatttattt caaaaatgcc aagactacct caagacccac cacgatctcc ctatagaaga
      361 aatcagagat atgcttgaag ttgtcattta tatccgtcaa cacggggcag gggaactatc
      421 agatcacgca gaacaggttg tcaaaaaact ttggagaaaa attgaaaaac aagatacatg
      481 gtatgagagt gatctaaaaa tcctcaatac cattcttttc agttttccca ttgaatacct
      541 ccatctcatc actggaaaaa tattgcaacg cctagaagtc tataaaaact atcaacattt
      601 atatgacttg cgaatagcaa tcctgctcaa cctttccaca ctctatctat acaatcaaga
      661 taaaaacatg tgtaagcaaa tctgctacac tttactggag gacgccaaga ataagaaaag
      721 ctacgatagg ctggctatct gctatgtccg cattgggatt tgtacagacg attctaaact
      781 tatccaaaaa ggtttctcac tcctagagct gaccgaggaa acttctatgc tgtctcatct
      841 caaaaaagaa gtagagatct attaccaagc gaaggaaaga taaaaaagcc gagggagctc
      901 ctcgaccttt tcatagaatc gccgaacgat ttaacgagaa agtatgactt ttacgtttat
      961 cccaactcaa ttatgacatt tttttcaaaa gtcaatatat ctcacttttt caacgacaag
     1021 aaagaggctg ataatctacc aacctcttat tctgaaccca tcactccatc actttttagc
     1081 ttcattcgct ttcttagcga ctgcaatctg gtattcgact tggtcattcc ccttaccggt
     1141 acaaccatga gcaattgtag tcgctcctat ctgatgcgct atttcaacca attttttaga
     1201 aatcagaggg cggctcaagg cagataccaa gggatacttt tgttcataat aggcatgtga
     1261 ctgaagagcc actagcacat aatctgtagc aaattcgtcc ttaacatcaa tgacataaga
     1321 ttctactgcc ccaaccttaa gagccttatc atggatgaaa tctaagtctt tcccttcacc
     1381 cacatccata caaactgaaa caacatcata gtctttcttt aaccaggtaa tagcaactga
     1441 tgtgtccaaa ccgccagaat aggccaaaat tactttttct ttactcatgt tcttttcctt
     1501 ctttctattt ttcaatggat gctttaaagg catcctcaat gagtttgtct aattccccag
     1561 actccttcaa cttttgaatg gttttatcga ctgcctcttt caattccttg ctatcttttt
     1621 tcatggctac cgcgtaggaa tcatcttgct ctttttcaaa attgaggtct gcgattgcta
     1681 aatcaggatt attttccaca aatcccttgg aaacaggttc ttcaaagata acggcatcca
     1741 cttgtcctga ttttaaatct gtgattaaat tcccattttt aggcagagat acgagggaag
     1801 aattttgtag caaatctttc gccatcgtct cttgaatcga acctttctgc gctccaacct
     1861 ttttctgcgc caagtcgttt acagactgat aagtagtcaa gtcagatttt ttgacaatga
     1921 gtttattttt tgcagtatag tagggaatgg aaaagtcaaa caccttgctc cgttcatctg
     1981 tcttagaaac acctgatatg gcaaggtcgg cttttcctga ttgaacacta gccagtacat
     2041 tatcaaaact catgggagat agttccaatt cgacacctag ttctgttgcg atagccttgg
     2101 ctaattcgat atctgaaccc acaatctgat ttttcccatc aaccactttt tggtattcaa
     2161 atggagcaaa atccggattg agggctacaa ccaattttcc tttggacttg atggcttcaa
     2221 ttccagccga ttgattgttg ctacaagcaa atagtagggg gagcatcact aaaccaaaca
     2281 tcgtcatcaa caccttcttc atcttattca taataaagcc tactttatgt ttattccttt
     2341 tgtttgtata aacaatacat ctatattcat cctttgtcaa gcctaaattg aaaaaatttt
     2401 caatttgaaa caaaaaaaac ctagaaatac tacataaaat gtcattccta ggcgtattta
     2461 tgctattttt ctctggaaaa catgagtatt cagccagtca aaaggagctg aatgaactca
     2521 ttttccctcg cccaattcaa tgacacgatg acattgttgg gctacataag catcgtgggt
     2581 cacaataatg actgttttcc cttctcgatt catctctaag agaaacttca agaccaaatc
     2641 tctattttca ggatccagcg aacctgtagg ttcatcggct aaaatcagct ggctgggttt
     2701 taagatggct ctagcaactg caattcgttg ttgttcgcca ccagacaact cggagaccct
     2761 ttgatgcaaa gtagctgaca aacctactct ctctaaaatc tcttccacct ttttgagctt
     2821 gtctttctta ggcaatttca catatttcag cgccagcatg agattgtact cgaccgtttc
     2881 atcatcaatc agggcaaaat tttgaaacag ataagagata tgttcacgga ttattgtttg
     2941 cgacttagca gaattaaccg ctagatttgt ctgaccaaaa atctcatacc gtccgctata
     3001 atcaccatct atcaaaccca ataaatttaa caaggtcgac ttcccactac cactcttacc
     3061 aacaatagct accaaatccc cctgatcaat cctgagagat aagttatcca aaatcacttt
     3121 tcccccaatg gttttggtaa tatttttcaa ctcaatcata agatgccccc tttcaataac
     3181 tctactagac ttcttttctc catcctagaa gctaagccta gcacaaatag tatatccaga
     3241 catgtaaaac ctgcaaacag tagaagtggt aagaacgcat gggcaaagaa aatcaagact
     3301 agaagaggga aactatagcc cagcaagagc agaacgagga gaggacggta gcgatcgacc
     3361 agtttccacc ccataaactt cttggtaatg atatccctgc gcttcaataa gaaagttgtt
     3421 actagtaaga agtaggaaat catcatgcta aggagaccaa acaaagcaaa gagtaggtta
     3481 aaattccgaa cagcatctct ataagaatcc actttctctt gttgaatggc ttgaatagat
     3541 gaaaatttta aataatttcc atctgacaat ttctcaacta actctgtaat ctctttttga
     3601 tgttgaaccg tattttcaat tttaatcgga ttatttaagc cagttgttga cagggaggct
     3661 ttctcatccc acatcatatc agaatcattg accaagctaa taattggatt ggagagattt
     3721 tcctttcgct tatcactata tgggaaaaat gaccaatctc cttcataata ggcaatctcg
     3781 acatccatct cctctatcgt tcgtttttgc tgctcttcat acttcatcga atgaaaggca
     3841 attaacttcc ccaagagctg atttttatct tcttcacctt tcgtacttgc tggcatcaaa
     3901 ataacttttt taataccggt atctggtagc ttgaatccct tgctctttag aaaattgcga
     3961 ttggcatagt aaacatccac cgtatctgtt aactgatatt gctgaatctg ttctgattgg
     4021 acaaaatttt ttacaggaag actgctactc tgcacatagc ccgcctgcgt tttttctacc
     4081 aaatcctgat aaaatcgata gaaataatct gtagatttcc ctgaccctgc tagctcttct
     4141 tgccacagat tatcattgag tttgaaggtt tctaaggtca ggtaattacc ttgacttacc
     4201 cactgttgct gataagcaag ttctttgttt tcttgttcta aacttctgcc caccccaatc
     4261 agtaaggccg tcagtaaaat agttgtccct attttcatca cataattgaa gataagacca
     4321 aatttgaaag atgaaaaacc tttcagcaga gagctgattg tcattttttg gattaagagg
     4381 taagtcaacc aactgataaa gagataaagc tgcaacagca aaaaatgaga caaccacagc
     4441 ataggaaaca aatcttttgg cttataatca agcaagaaaa acacgcctag attgatcaca
     4501 agagccccac ctaggaggag gtaaaggttg ccttttacaa catcagctaa aacagcccta
     4561 tcttgaaaac caagtaattt ttgtacccca actcttttca tctccatcat cggttgatac
     4621 actgtcacta acacaagaag caaaatagcc aagacaaaaa caatggcaga taaaagcaaa
     4681 tctcgattta tgacttccac tgcacttttg taggtcggct ctagcaaggt agcctggtct
     4741 atcttgaaaa aatcgctcca tttctgtaca atcctatcct tgtccatctc ttgtgtagaa
     4801 gttatcgtat agcgaccatt taaactacga gatgtatcct tgatataggt ttgaaaagtc
     4861 ataagctgaa taggtttggc ttttagaaag gtcggaatcg taccaagttt attggaaatt
     4921 tctttattac tatagactcc ttcaccatct gtggtaaaat caagagaaga aatcccaaac
     4981 tcttggtagg ggaaggtatc tttatcaaaa acaccagact tgaccacctc atcaccactg
     5041 tctgttttga tgatggagac tttatactcc tttgatacat cctcaaaaaa tcgaagaaca
     5101 gacgctgcag gttcgttaat atctttcaaa tacaaatcca aagaatctac agtctttccc
     5161 atttcttgaa tccgaaccac ttctcgtgta tagtttacat taaaaacaaa aaaagtggta
     5221 cacagaagca ggagtaacat acagaaatta ctgatttttt tcataaaagt gcctccacta
     5281 cagttttccc tctccaaata ggagagggaa gaattttact caaatccata gaaatattcc
     5341 attcctgttg gcggaatctt ggtgagggaa gctctagccc atgcctcagg ttttgcataa
     5401 tccttagagg ttctaccccc atgtctaaca gttgctgtat gatatcgagt agaatgtaag
     5461 taatcagaat atccaaaagt tcctgtccaa cctactccat agttccattg accaccctca
     5521 acccatactg ctaaagcatt tgtagtagca agtataccac ataccattaa agatgcaaca
     5581 ccaattttaa ctaattttct catgatttat ttctcctatt atcgagagct gttccgtaaa
     5641 aacagctata gtaatttatc aacaagtatc gtagtccatt ggactcacct tccttctatc
     5701 tcatttcatt tttaacaacg aacttactct taaccgggag aatggtgcgc ttctgtatca
     5761 ggtccttgaa caaccagagt agtattaagc acactctaac tattactcaa gaatcagtcc
     5821 aataaacaat atggatagcg ctttcaaatt tttaaactcc tatcccatcc ttttatctat
     5881 ataataagtg aaaatataat aactgtcaag taactgaagt gaattttata aaaaaattac
     5941 aagccaaatt tgtaaagttt acactaagcc gctagggcaa tcgtctatca gaatatccgt
     6001 ttatttgtca ataatccgag aaaatcttgc aacgcttaga agtctataaa aactatcaac
     6061 atttatatga cttgcgaata gcaatcctgc taaacctttc cacactctat ctatacaatc
     6121 aagataaaaa catgtgtaag caaatctgct acactttact ggaggacgcc aagaataaga
     6181 aaagctacga taggctggct atctgctatg tccctattgg gatttgtagg gatgatgcga
     6241 aacttatcca aaaaggtttc tcactcctag agctaaccga ggaaacttct atgctgtctc
     6301 atctcaaaaa agaagtagag atctattacc aagcgaagga aagataaaaa agccgaggga
     6361 tttcctcgac tctttacata ttatttgttc gttagttctt aataccagcc attgttaagc
     6421 cagaagtttt tagcagctgt ccatgaaccg taacgtcctg caacgtaggc atctgctaca
     6481 cgttcttggt tttcagctga gtagtcaccg ttcaggtatg aatctgttaa ttggtaacgt
     6541 ccgatataac gtccatttgt agctgtatag ctaccacctg attctttttg agcgatccat
     6601 tctttggctt ctgcttcaga tccgcttaca gttgaaacaa ctgtttcact tactactgga
     6661 gtttctgcca ctggagctga aacagtttca tcttgagcgg ctggtgccgc ataagtagct
     6721 ggcgctggtg ttgcaacagg cgctacaggg ccatcgataa ccaact
//
LOCUS       DBMVGT010000080         6336 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.080, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000080 DBMVGT010000000
VERSION     DBMVGT010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6336)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6336)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6336
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.080"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..764
                     /locus_tag="AC0DU4_001852"
     CDS             <1..764
                     /locus_tag="AC0DU4_001852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="lyase family protein"
                     /protein_id="HIN4237770.1"
                     /translation="ISGAVGNFANIPPFVEEYVCDKLGIRAQEISTQVLPRDLHAEYF
                     AVLASIATSIERMATEIRGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSENMTGLA
                     RVIRGHMITAYENVALWHERDISHSSAERIITPDTTILIDYMLNRFGNIVKNLTVFPE
                     NMIRNMNSTFGLIFSQRAMLTLIEKGMTREQAYDLVQPKTAYSWDNQVDFKPLLEADS
                     EVTSRLTQEEIDEIFNPVYYTKRVDDIFERLGLGD"
     gene            complement(819..4757)
                     /gene="strH"
                     /locus_tag="AC0DU4_001853"
     CDS             complement(819..4757)
                     /gene="strH"
                     /locus_tag="AC0DU4_001853"
                     /EC_number="3.2.1.52"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored beta-N-acetylhexosaminidase StrH"
                     /protein_id="HIN4237771.1"
                     /translation="MKHEKQQRFSIRKYAVGAASVLIGFAFQAQTVAADGVTPTTTEN
                     QPTIHTVSDSPQSSENRTEETPKAELQPEAPKTVETETPATDKVASLPKTEEKPQEEV
                     SSTPSDKADVVTPTSAEKETANKKAEEASPKKEEAKEVDSKESNTDKTDKDKPAKKDE
                     AKAEADKPETEAGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTD
                     LHLLVGNDGLRFMLDDMSITANGKTYASDDVKRAIEKGTNDYYDDPNGNHLTESQMTD
                     LINYAKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKESARTVDLDNEQAV
                     AFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQADKYYPNEGYPVKGYE
                     KFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGGWGGYDVAS
                     SKLLAEKGHQILNTNDAWYYVLGRNADGQGWYNLDQGLNGIKNTPITSVPKTEGADIP
                     IIGGMVAAWADTPSARYSPSRLFKLMRHFANANAEYFAADYESAEQALNEVPKDLNRY
                     TAESVTAVKEAEKAIRSLDSNLSRAQQDTIDQAIAKLQETVNNLTLTPEAQKEEEAKR
                     EVEKLAKNKIISIDAGRKYFTLNQLKRIVDKASELGYSDVHLLLGNDGLRFLLDDMTI
                     TANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIGLIPAINSP
                     GHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDLKNEEAMNFVKALIGKYMDFFAGKTKI
                     FNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGLQPMAFNDGFYYE
                     DKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYILGQKPEDGGG
                     FLKKAIENTGKTPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFA
                     DHNKDYFRANYNALREELAKIPTNLEGYSKESLEALDAAKTALNYNLNRNKQAELDTL
                     VANLKAALQGLKPAVTHSGSLDENEVAANVETRPELITRTEEIPFEVIKKENPNLPAG
                     QENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGAPVTHKGDESG
                     LAPTTEVKPRLDIQEEDIPFTTVTRENPLLLKGKTQVITKGVNGHRSNFYSVSTSADG
                     KEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDENGQAAIAEEKPKLEIPSQPAPSTAPA
                     EESKVLPQDPAPVVTEKKLPETGTHDSAGLVVAGLMSTLAAYGLTKRKED"
     gene            complement(5070..5786)
                     /locus_tag="AC0DU4_001854"
     CDS             complement(5070..5786)
                     /locus_tag="AC0DU4_001854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001007200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HIN4237772.1"
                     /translation="MAIPKYQYIKDELKNKIISGQFSSGDKFYTEAELISMYDVSSIT
                     VVRALNDLAKDGYIVRQQGKGTFVSRARKHKLVEFSDIELFNAKDDKVTVLSIERGNK
                     LVYLEKLGLRGDQFYYKIERIRESNGVVYIYHTSYIPEQYINANYPNLEYYSSIYNRF
                     KLDYHIHMNDEHFEEINEIVFPTPEHAASVLGVDEQFPTVLQTKITKLESTGQVLEYS
                     ETYKRSDYYKIEFISCDRDH"
     gene            6134..>6336
                     /locus_tag="AC0DU4_001855"
     CDS             6134..>6336
                     /locus_tag="AC0DU4_001855"
                     /EC_number="3.2.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-galactosidase"
                     /protein_id="HIN4237773.1"
                     /translation="MTRFEIRDDFYLDGKSFKILSGAIHYFRVPPEDWYHSLYNLKAL
                     GFNTVETYIAWNLHEPREGEFHF"
BASE COUNT         1638 a         1209 c         1342 g         2147 t
ORIGIN      
        1 agatttctgg tgcggttggg aactttgcca atatcccacc atttgtagag gagtatgtct
       61 gcgataaact tggcatccgt gcccaagaaa tctctacaca agtccttcct cgtgaccttc
      121 acgctgagta ctttgcggtt cttgccagca ttgcgacttc aatcgaacgt atggcgactg
      181 agattcgtgg tctacaaaaa tctgagcaac gcgaagtaga agagttcttt gctaaagggc
      241 aaaaagggtc ttcagcaatg cctcacaaac gcaacccaat cggttctgaa aatatgactg
      301 gtctggcgcg tgtcattcgt ggtcacatga ttacggctta tgaaaacgtc gctctctggc
      361 acgaacgcga tatttctcac tcatcagctg agcgtatcat cacaccagat acgaccattt
      421 tgattgacta catgctcaac cgttttggaa atatcgtcaa gaacttgaca gtcttcccag
      481 aaaatatgat ccgaaacatg aactcgactt ttggtcttat ctttagccaa cgggctatgt
      541 tgacattgat tgaaaaaggc atgacccgtg agcaagccta tgacttggtg caaccaaaaa
      601 cagcctactc ttgggacaac caagtagact ttaaaccact tcttgaggca gattcagaag
      661 taacatcacg tctcacacaa gaagaaatcg atgaaatctt caacccagtt tattacacca
      721 aacgagtgga tgatatcttt gaacgtcttg gactaggtga ttaattaaaa aataaacagc
      781 gagcttcaat ctcgctgttt attttttatc gaaaagactt agtcttcttt tcttttagtg
      841 agtccatagg ctgctagtgt ggacatgagt cctgcgacta ctagtcctgc agaatcgtga
      901 gttcctgttt caggaagttt tttctctgtt accacaggag ctggatcttg aggaagaact
      961 ttgctttcct cagcaggagc agttgatgga gctggttggc ttgggatttc tagttttggt
     1021 ttttcttcag caatagcggc ttgtccgttt tcatcgccta catgtgttac catagttccg
     1081 acttcgacta tttgagtaac ggcttcctgt gctacgacac tatttacaag tgttttcact
     1141 tccttaccat cggcagaagt gctcacagag tagaagttgc tacgatgtcc attgacgccc
     1201 ttagtaatga cttgtgtttt tcctttgagt aagagtggat tttcacgagt cactgtggta
     1261 aatggaatgt cttcttcttg gatatccagt ctaggtttta cctcagtagt tggtgcaaga
     1321 ccactttcat cacccttgtg agttacagga gcgccaactt caaccacttg gtttataact
     1381 tctttggtta cctggctatc aaggactgtt tctgttgttt ttccattttc agtgagtaca
     1441 gagatgtaat gagttcgttc acctttgact cctgctgtga taatattttc ctgaccggct
     1501 gggaggttag gattttcttt cttgataact tcaaatggaa tttcttcagt tcttgtgatg
     1561 agttctggtc tggtttcaac attggcagcc acttcatttt catctaggct tcctgaatga
     1621 gttacagctg gtttgaggcc ttgaagagcg gcttttaggt tggctacaag tgtgtcaagc
     1681 tcagcttgtt tattacggtt gaggttgtaa tttagagctg ttttagctgc gtcaagggcc
     1741 tcaagacttt ctttactata tccttctaag tttgtaggaa ttttagctaa ttcttcgcgg
     1801 agagcattat aattagcacg gaagtagtct ttgttgtggt ctgcaaaggc agtcatgagt
     1861 tcaaagattt cctcttcctt gtattcagcg cttggtctat ctgcccagat tgaaagcata
     1921 cttccgactg ttggaagatc tacttcagga tatttggtag aagctagttg attgaatggt
     1981 gtttttccag tattctcaat agctttcttg aggaaaccac caccatcttc tggtttttga
     2041 ccaagaatgt agtaccagtc accgttggta ttcaagaatt tatagccttt gcttgctagg
     2101 tattgaggtg atgcgaggtt atatccccac cagcctttag accagtaaga aatcaagaca
     2161 tctttgtcaa actgaacatc gtccttgtct tcatagtaga agccatcgtt gaaggccatt
     2221 ggttgaagcc ctctttcttt ggccatagct gcgagggtgt tggcatattc ggcaaatttg
     2281 ccatagagtt gataccactt gaggtagtac cagccttggg cactagtcgc atcgttggcg
     2341 tattcgtcag taccaaagtt gaaaatcttt gttttacctg caaagaagtc catgtattta
     2401 ccgatgaggg cttttacaaa gttcatcgct tcttcgtttt tcaagtccat agttgttttt
     2461 gaaactttat caaagtgggc ttgaggattt ttaataccta atttttccat ggcaaccagc
     2521 atagcatcca tgtgacctgg actgttaata gctgggatga gacctatgtc cttagattta
     2581 gcgtattcaa ttagctctgt cacttctgcc tgtgttagtg cagtaccgtt tggatcgtcg
     2641 tagtaagctt tagttccttc gataatagct tttttaacgt catcactagc ataggttttt
     2701 ccgttggcag taatggtcat atcatcgagt agaaagcgaa gtccgtcatt tcctagaagg
     2761 agatggacat cagaatatcc gagctcactg gccttgtcta cgatgcgttt gagctggttc
     2821 agagtaaagt atttgcgtcc agcatcgatt gagattatct tgtttttggc aagtttttca
     2881 acctcacgtt tagcttcttc ttctttttga gcttcaggcg tgagggtcaa gttgttgaca
     2941 gtttcttgaa gtttagcaat ggcttgatca atcgtatctt gttgggcacg gctaaggttg
     3001 ctatcgagag agcgaatagc tttttcagct tcttttacgg ccgtgacgct ttctgcagta
     3061 taacggttca ggtcttttgg tacctcgtta agtgcttgct ctgcagattc ataatcagct
     3121 gcgaagtatt cagcgttggc atttgcaaaa tgacgcatga gtttgaagag gcgtgatggt
     3181 gaataacgtg cagatggagt gtcagcccaa gcagctacca taccaccgat gattgggata
     3241 tcagctcctt ctgtttttgg tacagaagtg attggtgtgt ttttaatacc attgagcccc
     3301 tgatcgagat tgtaccagcc ttggccatca gcgtttcgtc caagaacgta gtaccaagca
     3361 tcattggtat taaggatttg gtgacctttt tcagctagta gtttagaaga agcgacatcg
     3421 tagcctcccc aaccaccagt ccacatagaa acgatgatgt ctttgtcaaa actaccaaag
     3481 cttgtgtcgc tattgtagta gataccgtcg ttaaaggcca ttggtttgag accgtgcgat
     3541 tttacaatac gagcgaggtc attggcgtag gcaataaatt tttcatagcc ttttacaggg
     3601 tagccttcgt ttggatagta tttatcagct tgaagcacac tccaaccttt agcatctgtc
     3661 gcatcattgg catattcatc aagtccgatg ttgaagattt cagtcttttt cgcgaaataa
     3721 gcagcatact tgtcgataag ggcttttgta aaagcgacag cttgttcgtt gtcaagatcg
     3781 acagtacggg ctgattcctt cccaaaatag ctaaagttag ggttttggat tcccaattct
     3841 ttcatggcat tgagaatcgc atccatgtgc ccaggactat ttactgtcgg aatgagaccg
     3901 atacctttat ctttggcata gttaatcaga tctgtcattt gactttctgt taagtgattg
     3961 ccgtttggat cgtcgtaata atcatttgta cctttttcaa tggcgcgttt gacatcgtca
     4021 ctggcatagg tcttgccgtt agctgtgatg ctcatatcgt ccaacatgaa acggagtcca
     4081 tcatttccga ctaataggtg taaatcagtg tagccataat gtttcgcttt atcgatgatt
     4141 tccttgagct gttctggtga gaaatattta cgtccagcat caatagaaac aattttcttt
     4201 ttcgctagtt tttcatttac agttgcagca cgttcctttc ctgcctctgt ttccggtttg
     4261 tcagcctctg ctttcgcttc atctttttta gctggtttat ccttgtcagt cttgtctgta
     4321 tttgactctt tagaatcaac ctctttcgct tcttcctttt tagggctagc ttcttctgcc
     4381 tttttattag cagtttcttt ttcagcagaa gttggagtta ccacgtctgc tttatcacta
     4441 ggagttgaac taacttcctc ttgtggtttt tcttctgttt ttggaagact agctacctta
     4501 tcagtagctg gagtttctgt ttctacagtt tttggagctt ctggttgaag ctctgcttta
     4561 ggtgtttcct cagtccgatt ttcggatgat tgaggggaat cagaaaccgt atggatggtc
     4621 ggttggtttt ctgtagtagt aggagtaact ccatcggctg caacagtctg tgcttggaag
     4681 gcaaatccaa ttagaacaga agctgctcct acagcgtatt tacgaataga aaaacgctgt
     4741 tgtttttcat gtttcattgc aaaacctcct gattgcattg ttatattgat agcgattata
     4801 taaatcaacg cctttatttt atttcttata ttaacgagag tcaagaggag atgacaaaaa
     4861 actataataa gtataaaaaa atataaaatt taaacttaag atttcagatt ggtcgaaaat
     4921 acatatatat atctagtata atttttggtt ctatttctat aaaatattcc acaaattata
     4981 gaatcttcca aaaataggta agcgctacct ttttggtgtg gtataataag catagaaaaa
     5041 gcccgagcga ttaggctcag gctttcttct tagtgatcac ggtcacatga gatgaattca
     5101 atcttgtagt aatcagatcg tttgtaagtt tcactgtatt ctaaaacttg gccagttgat
     5161 tcgagtttgg tgattttagt ttgtaggaca gtagggaatt gttcatcgac tccgaggact
     5221 gaagccgcat gttctggagt tggaaagact atttcgttga tttcttcaaa gtgttcatca
     5281 ttcatgtgaa tgtggtagtc taacttgaaa cgattataga tagaactata gtattcaagg
     5341 tttggataat ttgcgttgat atattgttct gggatgtagg atgtatggta gatataaacg
     5401 acaccgtttg attcgcggat acgttcaatc ttgtagtaga attgatcgcc gcgtagaccc
     5461 aatttttcca agtaaacaag cttgtttccg cgttcaattg aaagaacagt taccttatca
     5521 tctttagcat tgaagagttc aatatctgaa aactctacaa gcttgtgttt gcgtgcacgt
     5581 gaaacgaagg ttccttttcc ttgttggcgg acaatatagc catctttggc aaggtcgttt
     5641 aaggcgcgaa caactgtgat agagctgaca tcgtacattg aaatgagttc tgcttcagtg
     5701 taaaatttat ctccactgct aaactgccca gagatgattt tattttttaa ttcgtctttt
     5761 atgtattgat atttgggaat tgccatattt ttacctctat tttccttctc catagaaaat
     5821 tttaccataa aagcgaaaaa aatagtagtc ttttgaataa aaaattagaa taatagtttg
     5881 aaaaattaag cgatataggg attgctcata ttttatcaat gtattctata caaaattatt
     5941 ttaggtccta tattccgaat ttaaagagcg tttgaaatgg gtctaaaaat gtttgaaact
     6001 aattgaatgt gtgtataata gtaaaaatgc agtaaatatc ccgacaattt ctattgacaa
     6061 ttcaaacaga ttggtttata attaatataa caacaaatga aagcgcaaac tttcgcggtc
     6121 ggaaggtagt tttatgacac gatttgagat acgagatgat ttctatctcg atggaaaatc
     6181 atttaagatt ttatctggtg ccattcatta ttttagggtt cctccagagg attggtatca
     6241 ttcgctctat aacttgaagg ctcttggttt taatacggta gagacttata ttgcttggaa
     6301 tttacacgag cctcgtgaag gtgagtttca ttttga
//
LOCUS       DBMVGT010000081         6229 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.081, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000081 DBMVGT010000000
VERSION     DBMVGT010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6229)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6229)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6229
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.081"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..423
                     /locus_tag="AC0DU4_001856"
     CDS             <1..423
                     /locus_tag="AC0DU4_001856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AMP-binding enzyme"
                     /protein_id="HIN4237774.1"
                     /translation="FEFEGLPAYHTGDVGTITDEGLLLYGGRMDFQIKFNGYRIELED
                     VSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDSVREQFERDIDITKAIKEDLT
                     DIMMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR"
     gene            420..1664
                     /gene="dltB"
                     /locus_tag="AC0DU4_001857"
     CDS             420..1664
                     /gene="dltB"
                     /locus_tag="AC0DU4_001857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0070395 - lipoteichoic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HIN4237775.1"
                     /translation="MMEFFQQLPHLEPYGNPQYFVYVIAATLPIFIGLFFKKRFAWYE
                     VLVSLFFIVTMLVGGKTNQLAALGIYLCWEILLLLFYKHYRKSKDGKWVFYLVSFLSL
                     LPIIFVKVQPAINGTQSLLGFLGISYLTFRSVGIIIELRDGVIKDFTLWEFLRFLLFM
                     PTFSSGPIDRFKRFNENYQAIPERDELMDMLDESVRYIMWGFLYKFILAHVLGETLLP
                     PLKNLALQSGGFFNLYALAVMYTFGLELFFDFAGYSMFALAISNLMGIRSPINFNKPF
                     LSRDLKEFWNRWHMSLSFWFRDFVFMRMVMVLTRKKVFKNRNVTSSMAYIVNMLIMGF
                     WHGVTWYYIAYGLFHGLGLVINDAWVRKKKTLNKERKKAGKAALPENRWIQLLGMVVT
                     FHVVMLSFLIFSGFLNNLWFKK"
     gene            1678..1917
                     /gene="dltC"
                     /locus_tag="AC0DU4_001858"
     CDS             1678..1917
                     /gene="dltC"
                     /locus_tag="AC0DU4_001858"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005591431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0036370 - D-alanyl carrier activity
                     [Evidence IEA];
                     GO_process: GO:0019350 - teichoic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HIN4237776.1"
                     /translation="MDIKSEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVE
                     IENRFDIRVPVTEFGRDDWNTANKIIAGIVELQNA"
     gene            1910..3178
                     /gene="dltD"
                     /locus_tag="AC0DU4_001859"
     CDS             1910..3178
                     /gene="dltD"
                     /locus_tag="AC0DU4_001859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000919885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0070394 - lipoteichoic acid metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HIN4237777.1"
                     /translation="MLKRLWMIFGPVLIAGLLVFLLIFFYPTEMHHNLGAEKRSAVAT
                     TIDSFKERSQKVRALSDPNVRFVPFFGSSEWLRFDGAHPAVLAEKYNRSYRPYLLGQG
                     GAASLNQYFGMQQMLPQLENKQVVYVISPQWFSKNGYDPAAFQQYFNGDQLTSFLKHQ
                     SGDQASQYAATRLLQQFPNVAMKDLVQKLASKGELSTADNEMIELLARFNERQASFFG
                     QFSVRGYVNYDKHVAKYLKILPDQFSYQAIEDVVKADAEKNTSNNEMGMENYFYNEQI
                     KKDLKKLKDSQKSFTYLKSPEYNDLQLVLTQFSKSKVNPIFIIPPVNKKWMDYAGLRE
                     DMYQQTVQKIRYQLESQGFTNIADFSKDGGEPFFMKDTIHLGWLGWLAFDKAVDPFLS
                     NPTPAPTYHLNERFFSKDWATYDGDVKEFQ"
     gene            3333..3773
                     /gene="adcR"
                     /locus_tag="AC0DU4_001860"
     CDS             3333..3773
                     /gene="adcR"
                     /locus_tag="AC0DU4_001860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent transcriptional regulator AdcR"
                     /protein_id="HIN4237778.1"
                     /translation="MRQLAKDINAFLNEVILQAENHHEILIGHCTSEVALTNTQEHIL
                     MLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVIFYQLTDLAR
                     PIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEIK"
     gene            3773..4477
                     /locus_tag="AC0DU4_001861"
     CDS             3773..4477
                     /locus_tag="AC0DU4_001861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HIN4237779.1"
                     /translation="MRYITVEDLSFYYDKEPVLEHINYSVDSGEFVTLTGENGAAKTT
                     LIKASLGILQPRIGKVAISKTNTQGKKLRIAYLPQQIASFNAGFPSTVYEFVKSGRYP
                     RKGWFRRLNAHDEEHIKASLDSVGMWEHRDKRLGSLSGGQKQRAVIARMFASDPDVFI
                     LDEPTTGMDAGSKNEFYELMHHSAHHHGKAVLMITHDPEEVKDYADRNIHLVRNQDSP
                     WRCFNVHENGQEVSHA"
     gene            4470..5276
                     /locus_tag="AC0DU4_001862"
     CDS             4470..5276
                     /locus_tag="AC0DU4_001862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HIN4237780.1"
                     /translation="MLSLLSYDFIQRAFLAVIAMSLFSPVLGTFLILRRQSLMSDTLS
                     HVSLSGVAFGLVLGISPTVSTIAIVLIAAVFLEYLRTVYKSFMEIGTAILMSTGLAVS
                     LIVMSKGKSSSSMSLDQYLFGSIVTISEEQVISLFVIAAVVLILTFLFLRPMYILTFD
                     EDTAFVDGLPVRTMSILFNMVTGVAIALMIPAAGALLVSTIMVLPASIALRLGKNFKS
                     VMLLASAIGFLGMVAGLYISYYAETPASASITIIFVTVFILISLVRRFIK"
     gene            5286..>6229
                     /gene="adcA"
                     /locus_tag="AC0DU4_001863"
     CDS             5286..>6229
                     /gene="adcA"
                     /locus_tag="AC0DU4_001863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter substrate-binding
                     lipoprotein AdcA"
                     /protein_id="HIN4237781.1"
                     /translation="MKKISLLLASLCALFLVACSNQKQADGKLNIVTTFYPVYEFTKQ
                     VAGDTANVELLIGAGTEPHEYEPSAKAVTKIQDADTFVYENENMETWVPKLLDTLDKK
                     KVKTIKATGDMLLLPGGEEEEGDHDHGEEGHHHEFDPHVWLSPVRAIKLVEHIRDSLS
                     ADYPDKKETFEKNAAAYIEKLQALDKAYVEGLSQAKQKSFVTQHAAFNYLALDYGLKQ
                     VAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLN
                     PLESLTEEDTKAGENYISIMEKNLKALKQTTDQEGPAI"
BASE COUNT         1745 a         1201 c         1399 g         1884 t
ORIGIN      
        1 tttgagtttg aaggtctgcc agcctatcac acaggcgatg tgggaaccat aacagatgag
       61 ggcttgcttc tctacggcgg acgcatggac ttccagatta agttcaacgg ttaccgcatt
      121 gagttagaag atgtctctca aaacctcaac aagtctcgct ttatcgaatc tgctgtcgca
      181 gtaccgcgct ataacaagga ccacaaggta caaaatctat tggcttatgt catcttaaaa
      241 gacagtgttc gtgagcagtt tgagcgagat atcgatatta ccaaggccat caaggaagac
      301 ctgacagaca tcatgatgtc ctacatgatg ccatctaaat tcctttaccg agacagtttg
      361 ccactgactc caaatggaaa gattgacatc aaaggattga ttaacgaggt gaataagaga
      421 tgatggagtt ttttcaacag cttcctcatt tagagccata tggcaatcct cagtattttg
      481 tttatgtgat tgctgcaacc ttgcccatct ttataggcct ctttttcaag aaacgctttg
      541 cctggtatga agtgttggta agtctcttct ttattgtcac catgttggtg ggtggaaaga
      601 ccaatcaact agctgccttg ggtatttacc tttgctggga aatattgctc ctgcttttct
      661 acaagcatta tcgaaaaagc aaggatggca agtgggtctt ctacttagtt agttttctgt
      721 ccctacttcc gattatcttt gtcaaggtgc aaccagctat caatggaacg cagtctttgc
      781 ttgggttctt gggaatttct tacctgacct ttcgttcggt tgggattatc atcgagctga
      841 gagatggagt gattaaggat tttaccctct gggaattcct ccgtttcctt ctcttcatgc
      901 caactttctc gagtggtcca atcgatcgct ttaagcgatt taatgaaaat tatcaggcta
      961 ttcctgagcg agatgagttg atggatatgc tggatgaatc tgtccgctat atcatgtggg
     1021 gctttttgta taagtttatc ctagctcatg ttttaggaga gaccttacta cctcctctga
     1081 agaatttagc cttgcagtca ggtggcttct ttaatctcta tgccttggca gttatgtata
     1141 cttttggtct ggagctcttc tttgactttg caggttattc tatgtttgct ttggccatct
     1201 caaacttgat gggaatccgt agccctatca actttaacaa gcccttttta tcaagggatt
     1261 taaaggagtt ttggaatcgc tggcatatga gtctgtcctt ctggttccgt gactttgtct
     1321 ttatgcgaat ggtgatggtg ttaaccagaa agaaagtctt taaaaatcgt aatgtaacct
     1381 caagcatggc ctacattgta aatatgctga ttatgggatt ttggcatggt gtgacctggt
     1441 actatatcgc ctatggactc tttcatggac taggcttggt catcaatgat gcctgggttc
     1501 gcaagaaaaa aacgctcaat aaggaacgga aaaaagcagg gaaggctgcc ctacctgaga
     1561 atcgctggat tcagttgctt ggcatggttg tcactttcca tgttgtcatg ttgtcattct
     1621 taatcttttc tggattcttg aataatctat ggtttaaaaa ataaaaggaa ataaaatatg
     1681 gatatcaaat cagaagttat tgaaattatt gatgagttgt ttatggaaga tgtttctgac
     1741 atgatggatg aagatctttt tgatgcaggt gtcttggata gtatgggaac ggttgagttg
     1801 attgtggaga ttgagaaccg ttttgacatt cgtgtccctg taacagagtt tggtcgtgac
     1861 gactggaata cagctaataa aatcatagct ggtattgtgg agctacaaaa tgcttaaacg
     1921 cttatggatg atcttcggac cggtcttgat cgctggtttg ttggtttttc tgctcatttt
     1981 cttttatcct actgagatgc atcataatct aggagctgaa aagcgttcag cagtggctac
     2041 tactatcgat agttttaagg agcgaagtca aaaagtcaga gcactatctg atccaaatgt
     2101 gcgttttgtt cccttctttg gctctagtga atggcttcgt tttgacggtg ctcatcctgc
     2161 ggtattagct gagaaataca atcgttccta ccgtccttat cttttaggac aggggggagc
     2221 tgcatcgctt aaccaatatt ttggaatgca acagatgtta ccacagctgg agaataaaca
     2281 agttgtgtat gttatctcac ctcagtggtt cagtaaaaat ggctatgatc cagcagcctt
     2341 ccagcagtat tttaatggag accagttgac tagttttctg aaacatcaat ctggggatca
     2401 ggctagtcaa tatgcagcga ctcgcttact gcaacagttc ccaaacgtag ctatgaagga
     2461 cctggttcag aagttggcaa gtaaaggaga attgtcgaca gcagacaatg aaatgattga
     2521 attattggct cgttttaatg aacgccaagc ctcctttttt ggtcagtttt cggttagagg
     2581 ctatgttaac tacgataagc atgtagctaa gtatttaaaa atcttgccag accagttttc
     2641 ttatcaagca atagaagatg ttgtcaaagc agatgctgaa aaaaatactt ccaataatga
     2701 gatgggaatg gaaaattatt tctataatga gcagatcaag aaggatttga agaaattaaa
     2761 ggattctcag aaaagcttta cctatctcaa gtcgccagag tataatgact tgcagttggt
     2821 tttaacacag ttttctaaat ctaaggtaaa cccgattttt atcattccac ctgttaataa
     2881 aaaatggatg gactatgctg gtctacgaga ggatatgtac caacaaacgg tgcagaagat
     2941 tcgctaccag ttagaaagtc aaggttttac caatatagca gatttttcta aggacggtgg
     3001 ggagcctttc tttatgaagg acaccattca ccttggttgg ttgggttggt tggcttttga
     3061 caaggcagtt gatcctttcc tatccaatcc cacaccagct ccgacttacc atctgaatga
     3121 gcgctttttc agcaaagatt gggcgactta tgatggagat gtcaaagaat ttcaatagat
     3181 aatataatat agaagagttc aagaatgaaa ctagttttca cgttttttct tgactctttt
     3241 tttgcttgtg atataattaa ctggtaaaca aaatgtcaaa gaatagtatt tttctcttaa
     3301 aaaagagaag tctaaaagga aaggagtcag atatgagaca gctagcaaag gatatcaatg
     3361 cttttttgaa tgaggtgatt ttgcaggcgg aaaatcatca tgaaatccta ataggtcatt
     3421 gcactagcga ggtggccctg accaatactc aggagcatat ccttatgctc ttgtcagagg
     3481 aatctttaac aaattcagaa ttggcccgtc gtctcaatgt cagtcaggcg gcagttacca
     3541 aggccattaa gtctttggtc aaggaaggga tgttggaaac atctaaagat tctaaagatg
     3601 cgcgtgtgat tttttatcag ttgactgact tggctcgtcc aatcgctgag gagcaccacc
     3661 atcaccatga gcatacactt ttaacctatg aacaagtggc gactcagttt actccaaatg
     3721 aacaaaaagt gattcagcgg tttttgactg ctttagtagg agaaatcaaa taatgagata
     3781 tattacggta gaggatttgt ccttctatta tgataaggag cctgttcttg aacatatcaa
     3841 ttatagtgtt gatagtgggg aatttgttac cttgactggg gaaaatggag cggctaagac
     3901 gacgctcatc aaggccagtc ttggaattct gcaaccacgc attggaaagg tggctatttc
     3961 aaagacaaat acgcaaggta agaaattgag aatagcctat cttcctcaac aaattgccag
     4021 ttttaatgct ggttttccaa gtacggtcta tgaatttgtc aagtcgggtc gctatccgag
     4081 aaaaggctgg ttccgtcgtt tgaatgctca tgatgaggag catatcaagg ccagtctgga
     4141 ctcagttggc atgtgggaac atcgagacaa acgcttgggg tctctatctg ggggacaaaa
     4201 gcagcgagcg gtaattgcgc gtatgtttgc ttctgaccct gatgtgttta tcctagacga
     4261 gccgacaacg gggatggatg caggaagtaa aaatgaattt tacgaactca tgcaccacag
     4321 cgcccatcat catggcaagg ctgttttgat gattacccat gaccctgaag aagttaagga
     4381 ttatgcggat cgcaatattc atctagtccg taaccaagac tcgccatggc gttgtttcaa
     4441 cgttcatgag aatggccagg aggtgagcca tgcttagttt attatcttac gactttatac
     4501 aacgcgcctt tttggcggtt attgctatga gtcttttctc accggtattg ggaaccttcc
     4561 tcatcttgcg tcgtcagagt ttgatgagtg atacccttag ccacgtctca ctttcaggtg
     4621 tagcctttgg tctggttttg gggatttctc caactgtttc tactattgcc attgtcttga
     4681 ttgcggcggt ctttctggag tatctccgta cggtttacaa gagctttatg gaaatcggga
     4741 cagctatcct catgtcaaca ggtctggctg tttctctgat tgtcatgagc aagggtaaaa
     4801 gctcgagttc aatgagtttg gaccaatatc tctttggttc gatcgtgact atcagtgaag
     4861 aacaggtcat ttccctcttt gtcattgcgg cggttgtttt gattttgacc tttctctttc
     4921 ttcgtcctat gtatatctta acttttgatg aagatacggc ctttgtggat ggcttgccag
     4981 ttcgtaccat gtccattctt tttaacatgg tgacaggggt ggctattgcc cttatgattc
     5041 ctgcagcagg agctcttctg gtatcgacca ttatggtctt gccagctagt attgccctgc
     5101 gtctggggaa aaactttaaa tcggttatgc tgcttgccag tgcgattggc tttttgggaa
     5161 tggtagcagg actttacatt tcctactatg cagaaacacc tgcaagtgca agtattacca
     5221 ttatttttgt aactgtcttt atactaatca gtttagtaag acgttttatc aaataggaga
     5281 cgaacgtgaa aaaaattagc ttattactag ccagtctatg tgccttgttt ttagtggctt
     5341 gttccaatca aaaacaggca gatggtaaac tcaatatcgt gacaaccttt taccctgtct
     5401 atgaatttac caagcaagtc gcaggagata cggctaatgt agaactccta atcggtgctg
     5461 ggacagaacc tcatgaatac gaaccatctg ccaaggcagt taccaaaatc caagatgcag
     5521 ataccttcgt ttatgaaaat gaaaacatgg aaacatgggt acctaaattg ctagatacct
     5581 tggataagaa aaaagtgaaa accatcaagg cgacaggcga tatgttgctc ttgccaggtg
     5641 gcgaggaaga agagggggac catgaccatg gagaagaagg tcatcaccat gagtttgacc
     5701 cccatgtttg gttatcacca gttcgtgcca ttaaactagt agagcacatc cgcgacagct
     5761 tgtcagcaga ttatcctgat aaaaaagaga cctttgagaa gaatgcagct gcctatatcg
     5821 aaaaattgca agccttggat aaggcttacg tagaaggctt gtctcaagca aaacaaaaga
     5881 gctttgtgac tcaacacgca gcctttaact atcttgcctt ggactatgga ctcaaacaag
     5941 tcgcaatctc aggactttct ccagatgcag agccatcagc tgctcgcttg gcagaattga
     6001 cagagtatgt caagaaaaat aaaatcgcct atatctattt tgaagaaaat gcctcacaag
     6061 cccttgctaa cacactttca aaagaagcag gtgtcaaaac tgatgtcctc aatcctttag
     6121 aaagtctgac agaagaggac accaaggctg gagaaaatta catctctatc atggagaaaa
     6181 acctcaaggc tttgaaacaa acaacagacc aagaaggccc agcaatcga
//
LOCUS       DBMVGT010000082         6112 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.082, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000082 DBMVGT010000000
VERSION     DBMVGT010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 6112)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6112)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6112
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.082"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(7..1362)
                     /gene="rlmD"
                     /locus_tag="AC0DU4_001864"
     CDS             complement(7..1362)
                     /gene="rlmD"
                     /locus_tag="AC0DU4_001864"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HIN4237782.1"
                     /translation="MNLKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYC
                     QITSIRRNFVEAKLLKVNKKSKFRIVPSCTIYNECGGCQIMHLHYDKQLEFKTDLLHQ
                     ALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELK
                     DCLVQDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNR
                     QLNLTQLVKELVKDFPEVVTVAVNTNTAKTSEIYGEKTEIIWGQESIQEGVLNYEFSL
                     SPRAFYQLNPEQTEVLYSEAVKALDVDKEDHLIDAYCGVGTIGFAFAKKVKTLRGMDI
                     IPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIVDPPRTGLDDKLL
                     DTILTYVPEKMVYISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKK
                     V"
     gene            1400..2176
                     /gene="recX"
                     /locus_tag="AC0DU4_001865"
     CDS             1400..2176
                     /gene="recX"
                     /locus_tag="AC0DU4_001865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000705102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006282 - regulation of DNA repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HIN4237783.1"
                     /translation="MKITKLEKKKRLYLMELDNGDKCYITEDTIVRFMLSRDKVISEE
                     ELKEIQDFAQFSYGKNLALYHLSFKARTEKEVREYLKKYDIDKNIVSQVIANLKEDKW
                     INDGQYAYAIINANQVSGDKGPYVLTQKLAQKGISKSTIEEILNDFDFSEVAQRVANK
                     LLKKYEGKLPARALQDKIIQNLTNKGFSYFDAKIAFDELDSQVDQETTQELIFKELDK
                     QYTKYARKYEGYELKQRLTQVLARKGYDFSDIASALREYL"
     gene            2265..2798
                     /gene="ntdP"
                     /locus_tag="AC0DU4_001866"
     CDS             2265..2798
                     /gene="ntdP"
                     /locus_tag="AC0DU4_001866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0017110 - nucleoside diphosphate
                     phosphatase activity [Evidence IEA];
                     GO_function: GO:0017111 - ribonucleoside triphosphate
                     phosphatase activity [Evidence IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside tri-diphosphate phosphatase"
                     /protein_id="HIN4237784.1"
                     /translation="MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDH
                     TLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNMASPYYLDEEALKYI
                     DYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFS
                     EAYVNIWYKRYVELKNR"
     gene            complement(3156..3587)
                     /locus_tag="AC0DU4_001867"
                     /pseudo
     CDS             complement(3156..3587)
                     /locus_tag="AC0DU4_001867"
                     /inference="COORDINATES: protein motif:HMM:TIGR01716.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Rgg/GadR/MutR family transcriptional regulator"
     gene            complement(3679..4011)
                     /locus_tag="AC0DU4_001868"
     CDS             complement(3679..4011)
                     /locus_tag="AC0DU4_001868"
                     /inference="COORDINATES: protein motif:HMM:NF013540.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237785.1"
                     /translation="MKNYGEAFRYFRKLNGYSLEYAAADSISKSQLSRFERGENEISL
                     STFFELLSNINVSIENFCNHLEHYKRSERDDFLVNLSPNFYSLNIKGLEVIKNKQQKL
                     FEKSGKNS"
     gene            complement(4024..4797)
                     /locus_tag="AC0DU4_001869"
     CDS             complement(4024..4797)
                     /locus_tag="AC0DU4_001869"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HIN4237786.1"
                     /translation="MIDKVIEQYKSHDNLDIRVELHKKYSKNKLGFNNWIFSNYQITD
                     EVKVLELGCGTGELWKSNSDSIDKMKQLIVTDFSKDMVKSTKSVIGNRNNVNYEIMDI
                     QKISFENETFDIVIANMLLHHVNDIPKALSEVNRVLKTGGIFYCATFGENGVVNYLAN
                     LFKDEVNQDLENRTFTLQNGKRYLSRYFNSVDTLLYDDELQVTSIDDLVKYIQSFKGI
                     SEIGSLEEEIIRKRLESEFNNGMLIIPKEYGMFIARKES"
     gene            complement(5244..5999)
                     /locus_tag="AC0DU4_001870"
                     /pseudo
     CDS             complement(5244..5999)
                     /locus_tag="AC0DU4_001870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000567550.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA];
                     GO_function: GO:0052693 - epoxyqueuosine reductase
                     activity [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA];
                     GO_process: GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase QueH"
BASE COUNT         1977 a         1110 c          944 g         2081 t
ORIGIN      
        1 ccttttttaa acttttttta ttaattttac aacagcttca gttcgagctg tatgtgggaa
       61 catatcgacc gactggatat aatgaagatc atagacttct actaagcgta ccaaatcacg
      121 agccaaggtc gaaacattac aagaaatata aaccattttt tctggtacat aagtaagaat
      181 agtatctaat aacttatcat ccagacctgt acgtggtggg tcaacaatca aagcatctgc
      241 tcggtagcct tccttgtacc aacgaggaat aatctcttct gccgttccag cttcataatg
      301 agtattgtca aatcccattc ttttagcatt tcgcttggca tcttcaatag cttctggaat
      361 aatatccata cctctgagtg tttttacttt ctttgcaaag gcaaatccaa tcgttccaac
      421 tccacaataa gcgtcaatca aatggtcttc tttatcaaca tccagcgctt ttactgcttc
      481 gctatagagg acttctgttt gctcaggatt tagttgataa aaagctcgag gggatagtga
      541 aaattcataa ttgagtacac cttcttgaat actctcttgc ccccagataa tctctgtctt
      601 ttcaccatat atctcactgg ttttagctgt atttgtatta acagctactg tcacaacttc
      661 tgggaaatct ttaaccaact cttttaccaa ttgagttaaa ttaagctggc ggtttgtaac
      721 aataataatc tgaacctgtc cggtctttct cgcgcgtcgg accataatag tacggacacc
      781 tagaactttt ctctcatccg tgattggaat ctggtgataa gtaagtaatt ctgctaagcg
      841 attagcaatc acttgggttt ccttatcttg taccaggcag tctttcaact ctactaaata
      901 gtgagagttt tgtgcatata agcccgcctt gacctgattt ttaaattttc gagtctgaaa
      961 ttgtaactta gctctgtaat attttggttc ctgcattcca atagttggac gaatttcata
     1021 attttcatat cctgcaggag caaatttttt cagcgcttga tgaagtaagt ccgtcttgaa
     1081 ctccagctgc ttatcataat gcaggtgcat gatttggcag cctccgcatt cattataaat
     1141 agtacaagat ggcacaattc gaaatttaga cttcttgttg accttcagta attttgcttc
     1201 aacaaagttg cgtctaatag aagtaatctg acaatagata tcttcgcctt tgagagctcc
     1261 aggtacaaag actaatgttt tttggtaaaa gccgattccc tcaccgttaa ttcccatgcg
     1321 cttgattttt aatggtattt tttgtttcac tttcagattc atacccctat cttatcacat
     1381 tttgagttat aatagagcta tgaaaatcac aaaacttgaa aagaaaaaaa gactctatct
     1441 gatggagctt gataatggcg acaaatgcta tatcaccgaa gatacaattg ttcgttttat
     1501 gttatcgaga gataaggtga taagcgaaga ggaattgaaa gagattcaag actttgctca
     1561 attttcttat ggtaagaatc tggccctcta ccacttatcc tttaaagcac gcactgaaaa
     1621 agaagtcaga gaatatctga aaaaatacga tattgataaa aacatcgttt ctcaagttat
     1681 tgctaatctt aaagaagata agtggattaa tgatggtcag tacgcttatg ctatcatcaa
     1741 tgccaatcaa gtttcaggag acaagggacc ttatgtactg actcagaaat tagcacaaaa
     1801 aggaatttca aaatctacta tagaagaaat cttgaatgat tttgattttt cggaagttgc
     1861 tcaacgtgta gccaataaac tattgaaaaa atatgaggga aaacttccag ctcgtgccct
     1921 gcaagataag attatccaga acttgactaa caagggcttc tcttattttg atgctaaaat
     1981 tgcctttgac gaattggata gtcaagttga ccaagaaacg actcaggaac tcatcttcaa
     2041 ggaacttgat aagcaatata ctaagtatgc ccgaaagtat gaaggatacg aactgaagca
     2101 gcgtttaact caagttttag cacgaaaggg ctacgatttt tcggatatag caagcgctct
     2161 tagagaatat ctttaatatt tccaagtgaa attcacagat tttaggtaat tttatggtac
     2221 aatagtaaat gataaactta taaattgtag aaagttggtt agttatgaag cttccaaaag
     2281 aaggcgactt tattacaatt caaagttata agcatgatgg gagtctccac cgaacttggc
     2341 gggacaccat ggtactaaaa acaacagaaa acgccattat tggtgtcaac gatcatacac
     2401 ttgttaccga aagtgatggt cgtcgttggg tcactcgaga accggctatt gtttactttc
     2461 acaagaaata ttggtttaat atcattgcca tgattcgtga taatggaact tcttactatt
     2521 gcaatatggc tagcccctac tatctggatg aagaagcact gaagtatatt gattacgatt
     2581 tggatgttaa aatttttaca gatggggaaa aacgtctctt ggacgttgaa gaatacgagc
     2641 gtcacaaacg caaaatgaat tattctgatg acttggacta tattttaaaa gaacatgtca
     2701 aaattcttgt tgattggatt aacaatggac gtggtccttt ctcagaagcc tatgtaaaca
     2761 tttggtacaa gcgctatgta gaactaaaga atcggtaaag ttgtcaaagg tcaggaacaa
     2821 aatcctgacc ttgttttttt ggtagtataa aataaattgt gtaaacacaa aaaggaataa
     2881 atccattata gcagagttac aacacattac tagaaagaga tttatgcaga attcgtaaaa
     2941 tatataaaac aaatagatat actattattt tttaatgtct ttattcctag taagtttaca
     3001 acaaacttat atcgtttaat acaaaaaata cgaaaatgat tagtataaaa aatacaggtc
     3061 aacttcgtat caaaaacatt tttttgtatt tccacatagc atcaatcatt tagtacaata
     3121 ttttaaaaac aatatcttaa cagagaaaat gatatttaat ctatcagctc atttaatcgt
     3181 ttttgaaaat ataaagcaat acttttagat tcaataaact caaaatattt tatgacattg
     3241 tccatttgtt taattccaga ttctttagat tctgtcaggt atattttata tccttctaca
     3301 aatttgaatg tagatttttc aaaaactttt gtgtcatctt ttaataattt ttgtaatttc
     3361 atttcaaagt agtctgcata tattagatgt gaattttcaa ggcaacagaa ccaaaaattt
     3421 aaacaagctg acacaactaa atgtctattc ttgccgattt tttcgtaata atgtgtacgc
     3481 tctagtattt cttttccgac catgtaaata taatctattt caaaaagatg atataaatta
     3541 ccaatcagcg ttatctcata ggacttccat cgttccttct ggaataaata gtcatatact
     3601 aaatttagat catctctact aactacatga ttacaatcta gctgatttca taatccctga
     3661 accataattg tatttatttt atgagttttt cccactcttc tcaaaaagtt tttgttgctt
     3721 attttttatt acctccaatc ctttaatatt caaactataa aaatttggag ataaattaac
     3781 caaaaaatca tcacgctccg atcttttata atgttctaag tgattacaaa aattctctat
     3841 cgaaacattg atatttgata ataattcaaa aaatgttgaa agagaaattt cattttctcc
     3901 cctttcaaat ctagaaagtt gagattttga tatagaatca gctgcagcat actctaaaga
     3961 atatccgttt aattttctaa aatatcgaaa agcttctccg taatttttca cactttcatt
     4021 cccttaactt tcttttcgag cgataaacat accatattct ttaggaatga tcaacatacc
     4081 attattaaac tcactttcca atcttttacg tattatttcc tcttctagtg aacctatttc
     4141 tgaaattcct ttaaacgatt ggatgtattt aactaggtca tctatactag ttacctgtaa
     4201 ctcatcatca tagagtaatg tatcgacaga gttaaaatac ctactcaggt accttttacc
     4261 attttgtaaa gtaaacgttc tattttctaa atcttgatta acctcatctt taaataaatt
     4321 tgccaaataa tttacaactc cattttcacc aaatgtagca cagtaaaaaa ttcctccggt
     4381 ttttaagacc ctattcacct cagagagagc tttaggaata tcattcacat gatgtagaag
     4441 catattagca ataacaatat caaaagtttc attctcaaaa gaaatctttt gaatatccat
     4501 tatctcataa ttgacattgt ttctatttcc aatcactgac ttcgttgatt ttaccatatc
     4561 tttagaaaaa tctgtaacaa tcaactgctt cattttatct atagaatcac tattactttt
     4621 ccacaattct cctgtaccac atcccaattc tagaaccttt acttcatcag tgatttggta
     4681 gttagaaaat atccaattat taaatcccaa tttatttttt gaatacttct tatgcaattc
     4741 tactcgaata tcaagattat catgactttt atattgttca attactttat caatcatttt
     4801 aaatgacctc cactctataa tttggcatta tatcacaaga ataaagatag tgttaaataa
     4861 gttgtataaa tgcaaaaaag gaatattccg ttatagcaga gttgtaacac atttctataa
     4921 agaaatttat tcctacgact cagtttggca tgcttaactt cctaactcaa aaacaaagca
     4981 tcgattaatt tatccgttct tcttttgaaa cagatttgaa ctgataattg ctcgttttaa
     5041 tttaagaagc tcttttgagc aaaacttcat ttttttaaga gtccaacaat ttctgtctat
     5101 cgcttttcta ctagcaaaaa aaactacctt gaggcaagtt ttcatttata tatctaattt
     5161 cgtaatagta tagtaaaatg aaataaggac agtcaaatcg atttctaaca atgttttaga
     5221 agtaaaggtg tactattcta gtttcaatct actataaatt tgatatgaga atagtctttc
     5281 tcaacatcct tacccaacaa gaatgctgta gcgtccttct taacttgaac caggtcaata
     5341 ttctgggctt gggctgcata gacgcagcca caataacatt gacgatagat atcatactcc
     5401 tcacacatct ctactgaacg tttgtagcct tgatttttct tgaaatcgtt gggaagatag
     5461 tgggtcgtgt aaattttttg cacatcgatt ccgatgctgt tgatggtttg agaattctta
     5521 tgaggactga tggtcaaggc tgaaccaaag tagtcaaagc ccaagtccat agccacttgc
     5581 gctgttttat ccagtcggta gtcaaaacaa accttgcaac ggtcgccacc ttcgggctcc
     5641 tcctctagtc ccctaactag ttttcggtat taattgggtt cgtagggagc ttctaggtac
     5701 tgaaccgtat ttcctgtccg ctcattaaaa tcactaacaa atttcttgat gacatagacc
     5761 cgcttatggt attctacctt gggatggata ttagaattgg caaaatagat ggtcacatct
     5821 gcatacttgg tcaaatattc tagtgtatag gtactacaag gggcacagca aacatgcacg
     5881 agaatggttg gccgctgctc atttttctcc catgcttgta ccattttctg catgacacgg
     5941 tcataattaa tcttctgatt ggggggcatc ttgcacagaa tttcttctac atcgatcatg
     6001 ttcttctcct ttttctagtc ttattttatc atataagtta ggagagctca aatcaattta
     6061 gaagtgaata ttataaaaag aagggttagt cattccctcc ttttgtgttt tt
//
LOCUS       DBMVGT010000083         5994 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.083, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000083 DBMVGT010000000
VERSION     DBMVGT010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5994)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5994)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5994
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.083"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            56..423
                     /locus_tag="AC0DU4_001871"
                     /pseudo
     CDS             56..423
                     /locus_tag="AC0DU4_001871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865040.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            531..1532
                     /locus_tag="AC0DU4_001872"
     CDS             531..1532
                     /locus_tag="AC0DU4_001872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000789954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HIN4237787.1"
                     /translation="MKNINGKKVTIYDIARLSGFSPKTVSRVINGGVNVKEETYQAIQ
                     KVIEELSYIPNAYAKNLTKKEAINILISVKKIDSFPLIWFHTLLDKVLRTCKEFGVNA
                     IVEYFGEEDTISNSIISSTGSLVDGVIVFYESVDDIRIQYLKKNHMPFLVFGESQTSG
                     VVYVSNNNFQATYDMMKAVTEEKFKNMWLLMGGESHVNKDRERGVRSFLNDKNYFMDL
                     KVIYGLSTIDSVYSYAMQHLTTQNYPDIIFVSGDEKVQGLIRACYEKGILIPDDISII
                     GFDNIPISQYYTPALSTIAPNYVKLAKEMIEGVLAIIKGESVTSVEVSPKFVRRQSF"
     misc_binding    1744..1973
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            2203..2346
                     /locus_tag="AC0DU4_001873"
     CDS             2203..2346
                     /locus_tag="AC0DU4_001873"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237788.1"
                     /translation="MDRTDEVSSKYCFEVVDRTDEVSNHTYGKATLTRFEELFEEYKD
                     VPR"
     misc_binding    2421..2646
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            2718..4079
                     /gene="trpE"
                     /locus_tag="AC0DU4_001874"
     CDS             2718..4079
                     /gene="trpE"
                     /locus_tag="AC0DU4_001874"
                     /EC_number="4.1.3.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004049 - anthranilate synthase activity
                     [Evidence IEA];
                     GO_process: GO:0000162 - L-tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate synthase component I"
                     /protein_id="HIN4237789.1"
                     /translation="MERIIHGDVLSPILAYMRLKGQHKVILESIPRDKETARFSILAY
                     NPVFEIKFENGVLYQNGQVIDRDPLDFLYEVIHKSQHHSELPFGGGAIGFVGYDMISL
                     YEEIGQIPEDTIGTPDMHFFVYESYMVFDHKKEKIHVIEDALYSERSQEALEKSLNQV
                     LEELRIPAPNEFEDLDLSPLDFKPHIAPHKFEEMVETARDLIRNGDMFQCVLSQRFSA
                     EVTGNPFDFYRNLRVTNPSNYLYLYDFGDYQIIGASPESLVSVKNGIVTTNPIAGTRP
                     RGATDEEDKALATDLLSDEKETAEHRMLVDLGRNDIGRISETTSVQVTKYMEVELFRY
                     VMHLTSVVKGRLLPELTAMDALKATLPAGTVSGAPKIRAMRRIYELETEKRGVYAGAI
                     GYLSATGDMDLAIAIRTMILKNQRAYVQAGAGIVYDSIAQNEYQETINKTKSMTRIGE
                     LRP"
     gene            4076..4642
                     /locus_tag="AC0DU4_001875"
     CDS             4076..4642
                     /locus_tag="AC0DU4_001875"
                     /EC_number="4.1.3.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004049 - anthranilate synthase activity
                     [Evidence IEA];
                     GO_function: GO:0046820 - 4-amino-4-deoxychorismate
                     synthase activity [Evidence IEA];
                     GO_process: GO:0000162 - L-tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HIN4237790.1"
                     /translation="MILLIDNYDSFTYNLAQYIGNFAEVQVLRNDDSKLYEEAEKADG
                     LVFSPGPGWPVDAGKMEDMIRDFAGKKPILGICLGHQAIAEVFGGKLGLAPKVMHGKQ
                     SNINFEAPSVLYQGIEEGRAVMRYHSILIEEMPEDFEVTARSTDDQAIMGIQHKNLPI
                     YGFQYHPESIGTPDGLSSIRNFIEKVVK"
     gene            4653..5657
                     /gene="trpD"
                     /locus_tag="AC0DU4_001876"
     CDS             4653..5657
                     /gene="trpD"
                     /locus_tag="AC0DU4_001876"
                     /EC_number="2.4.2.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004048 - anthranilate
                     phosphoribosyltransferase activity [Evidence IEA];
                     GO_process: GO:0000162 - L-tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="HIN4237791.1"
                     /translation="MKEIIEKLAKFENLSGVEMTDVIERIVTGRVTEAQIASLLLALK
                     MKGETPEERTAIAQVMRGHAQHIPTEIHDAMDNCGTGGDKSFSFNISTTAAFVLAGGG
                     IHMAKHGNRSISSKSGSADVLEALGINLDLKPAELGKVFDKTGIVFLFAKNMHPAMKY
                     IMPARLELGIPTIMNLTGPLIHPMALETQLLGISRPELLESTAQVLKNMGRKRAIVVA
                     GPEGLDEAGLNGTTKIALLENGEISLSSFTPEDLGMEGYAMEDIRGGNAQENAEILLS
                     VLKNEASPFLETTVLNAGLGFYANGKIDSIKEGVALARQVIARGKALEKLRLLQEYQK
                     "
     gene            5654..>5994
                     /locus_tag="AC0DU4_001877"
     CDS             5654..>5994
                     /locus_tag="AC0DU4_001877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011227478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indole-3-glycerol phosphate synthase TrpC"
                     /protein_id="HIN4237792.1"
                     /translation="MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDR
                     LQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREIS
                     SQVEIPTLNKD"
BASE COUNT         1866 a         1002 c         1345 g         1781 t
ORIGIN      
        1 tttttagatg ttttaatcat ctaatttttg agtagatttt tgctcagagg tttttatgaa
       61 agattataaa atcaattttg atttaggtaa aatagaatat ttgataataa ttgtttgata
      121 caagtataca aatttatttc tttttatgat atttgtgaaa tggtgtttgc ctttcattta
      181 cctcttgatg agttgataac aaatgttatc tttaaagaaa aaattaactc tatgttaaaa
      241 tgttacattg acaggctatt atatgttttt ataaatccta cacattttac tgaaaaagtt
      301 aatctacaat tttatggcag ttttttctca tatgaattta tttgtcgtga agttggaaac
      361 attcttaaaa ataaaggtgt gaaatgcaat ttaaactttt ttgaagggaa agaatatttg
      421 taaaattaat tttgtgaatt tgtggatctt aaataattta ctaaattctc ttgttaaaaa
      481 aaattaaata ttgtatagta atattagaat gttcgtaatg gaggactgaa atgaaaaata
      541 taaatgggaa aaaggtaact atttatgata ttgcacgttt atcaggtttt tctccaaaaa
      601 cagtttcacg agttattaat ggtggagtaa atgttaaaga agaaacttat caagcgattc
      661 aaaaagttat agaggaattg tcgtatattc caaatgcgta tgcaaaaaat ttaactaaaa
      721 aagaagctat aaatatattg atttctgtaa aaaaaatcga ctcttttcct ttaatttggt
      781 ttcatacgct gttagataaa gtgttacgga cgtgtaaaga atttggtgtt aatgctatag
      841 ttgagtactt tggagaggag gatacaatta gtaattcaat tatatcaagc acaggtagcc
      901 tagtagatgg tgttattgtt ttttatgaaa gtgtagatga tatcagaatt cagtatttaa
      961 agaagaacca tatgcctttt cttgttttcg gtgaatctca aacgtctgga gtagtctatg
     1021 tatctaataa taattttcaa gctacttatg atatgatgaa agctgtaact gaagaaaaat
     1081 ttaaaaatat gtggttgctt atgggaggag aatcccatgt taataaggat cgtgaaagag
     1141 gtgtgcgttc ttttctgaat gataaaaatt actttatgga tttaaaagtc atttatggct
     1201 tatctacaat tgattcagtt tattcttatg caatgcagca cttgactacc caaaattatc
     1261 cggacattat ttttgtttca ggagatgaaa aggttcaggg cttgattcgt gcgtgctatg
     1321 agaaaggaat tcttattcca gatgatattt ctatcattgg atttgataat attcctattt
     1381 ctcagtatta tactccagct ttgtctacaa ttgctcccaa ttatgttaaa ttggctaaag
     1441 aaatgataga aggtgtttta gcaattatta aaggggaaag tgtcacatct gttgaagttt
     1501 ctcctaaatt tgttaggaga cagagtttct agtattgttt aattcttgaa aatcctagtg
     1561 gaaaagatgg agtgttctaa aataagttct gtttagcctc cattcagttt ctattgagtt
     1621 ggatccaatt tctaacaagt gggacatgtt catgttcgat ctaaggaaga catggtcata
     1681 ttcgaatgat attttcaaaa aaatcgtaaa aaagtcttga caaagaaaaa acaaagtatt
     1741 aaaataagtt caacaaatca gaaaagtaac tatttttgat cttcagggag cctgtggtga
     1801 ttgtgaatag gtggttggaa gtagtgaaag tgggctgatt ttgaaaatga atttgaaaca
     1861 atgaaaattc ggtgcgcaca ccttacagtg cagcttgttg ttaaacaagg cagagatgta
     1921 aagggatagt ccctttataa ttgaggtggc accgcgttac caacgccctc acacggaagt
     1981 atattctgtg tgtgggcttt tttctatccg tcgtttggtt tatcttttat tagggcctta
     2041 agtcgctttg atgaacttga gttctatcta cagctccttg cctactacta aaagcaaaca
     2101 aaaaggctgg actaatacga aaaaagctag taatactcaa tgaaaatcaa agagtaaact
     2161 aggaaactag ccgcaggttg ctcaaaacac tgttttgagg ttgtggatag aactgacgaa
     2221 gtcagctcaa aatactgttt tgaggttgtg gatagaactg acgaagtcag taaccatacc
     2281 tacggcaagg cgacgttgac gcggtttgaa gagttgttcg aagagtataa agatgtaccg
     2341 agatgaacat ctcttcatca atgtctctgg tcgtggaggc aaggacctag ctgcgattgc
     2401 agactactag aagctaaaaa ataatagatg gaaaaattac agttctttct ctcacagaga
     2461 gcttgtggtt gctgaaaaca agcagagaaa gctgtaaagt tgggttcatc tgaaacgaga
     2521 gaagaaaaca tcattctcaa gggagtgccc tttatcgcac agcctgttac aggagatatc
     2581 tgagacagga atgagagata ggagaaatcc tataattgag gtggcaccgc gaatttcgtc
     2641 ctcacgcaag ttattttgcg tggggatttt tcatacagtc accactgact agaagtagaa
     2701 ctgaaaggga aattacaatg gaacgaatca ttcatggaga tgtcttatca ccaatcttgg
     2761 cttatatgcg cttaaagggg caacataagg ttattttaga gagtattccg agagacaagg
     2821 aaacagctcg tttttctatc ctagcctata atccagtttt tgagattaag tttgaaaatg
     2881 gagttctcta tcaaaatggt caagtgattg atcgggatcc cttggatttc ctttatgaag
     2941 tgattcataa gagtcagcac cactcagagc taccttttgg tggtggagcc attggttttg
     3001 tgggttacga tatgatttcg ctttatgaag aaattggtca aatccctgag gatacaattg
     3061 ggacgccaga catgcatttc tttgtctatg agagctatat ggtctttgac cacaagaagg
     3121 aaaaaatcca tgtcatagag gatgcacttt atagtgagcg cagtcaagag gccttggaaa
     3181 aatccttgaa ccaagtgctt gaggaattac gcattcctgc tccaaatgaa tttgaagact
     3241 tggatctatc tccgttagac ttcaaaccgc atatcgctcc acataaattt gaggaaatgg
     3301 tggaaaccgc tcgcgacttg attcgtaatg gcgatatgtt ccaatgtgta ctcagtcagc
     3361 gcttctcagc agaagttact ggaaatccat ttgacttcta cagaaatctc cgcgtgacca
     3421 atccatccaa ttacctctat ttatatgact ttggggatta tcaaatcatc ggagccagtc
     3481 cagaaagttt ggtttctgtc aaaaatggca tcgtgacaac caatccgatt gcagggacgc
     3541 gaccaagagg ggctacggat gaagaagaca aggccttggc gactgacctc ctctctgatg
     3601 agaaggaaac agcagaacat cgaatgttgg tagacttggg gcgtaacgat attggccgca
     3661 tctctgaaac gaccagtgtc caagtcacta agtatatgga agtggagctc ttccgctacg
     3721 tcatgcattt gaccagcgtg gtcaaggggc gtttgcttcc agaactcact gctatggatg
     3781 ccttgaaagc aacgcttcct gctggaaccg tttctggagc gccaaagatt cgagctatga
     3841 gacgtatcta tgaactggaa acagaaaaac ggggcgtata cgcaggagca atcggctact
     3901 tgtctgcgac gggtgatatg gatttggcca tcgccatccg aaccatgatt ctcaaaaatc
     3961 aaagagctta tgtgcaggct ggggcaggga ttgtctacga ctctatcgcc caaaacgaat
     4021 accaagaaac cattaacaaa acaaaatcta tgactagaat tggagaacta agaccatgat
     4081 tttattgatt gacaactatg attcttttac ctataacttg gcccaataca ttgggaattt
     4141 tgcagaagtt caggttctga gaaatgatga ttccaagctg tatgaagaag ctgaaaaagc
     4201 agatggtctg gtcttttctc ctggtcctgg ttggccagtt gatgctggaa agatggaaga
     4261 catgattcgt gattttgcag gcaagaagcc gattctaggg atttgtttgg gccaccaagc
     4321 cattgcagaa gtctttggtg gtaagctagg tttggctcca aaagtcatgc atgggaaaca
     4381 gagcaatatc aactttgaag cgccatctgt tttgtatcaa ggtattgagg aaggacgtgc
     4441 ggtcatgcgt tatcacagta ttttgattga ggaaatgcca gaagactttg aagtgacagc
     4501 tcgttcgact gatgaccaag ccatcatggg gattcaacat aaaaacctac cgatttatgg
     4561 cttccagtac catccagaga gcattggaac gccagacggc ttgtcttcta ttcggaattt
     4621 tatcgagaag gttgtaaagt gaggaaacta ggatgaaaga gattattgaa aaactagcaa
     4681 aatttgaaaa tttatcaggt gtggaaatga cggatgtcat tgagcgtatc gtaactgggc
     4741 gtgtaactga agcgcagatt gcttctctcc tcttagctct taagatgaag ggggaaacac
     4801 ctgaagaacg cacagccatt gcccaagtca tgagaggaca tgcccagcat attccaactg
     4861 agattcatga tgccatggac aactgtggta caggtgggga caagtctttc agttttaata
     4921 tttccacaac tgcagccttt gtcttggctg gtggcggtat tcacatggcc aagcatggta
     4981 accgctcgat ttcttctaaa tctggttccg cagatgtcct cgaagccttg ggaatcaatc
     5041 ttgacctcaa accagctgaa ctaggtaagg tctttgataa aactggaatc gtctttctct
     5101 tcgctaaaaa tatgcaccca gctatgaaat acatcatgcc agctcgtttg gaattgggaa
     5161 ttccaacgat tatgaacttg actggtccac tgattcatcc aatggcttta gaaacacagc
     5221 ttcttggaat tagtcgtcca gaactcctag aaagtacagc tcaggttttg aaaaatatgg
     5281 gtcgcaaacg tgccatcgtg gttgctggac cagaagggtt ggatgaagct ggcttgaacg
     5341 gaacaaccaa gattgcactt cttgaaaatg gcgaaatcag cttgtcaagc tttactccag
     5401 aggatttggg aatggaaggc tatgctatgg aagatattcg tggtgggaat gctcaggaaa
     5461 atgcagaaat tttgcttagc gttctgaaaa acgaagcaag tccattcttg gaaacgacag
     5521 tcttgaatgc tggtcttggt ttctatgcta atggtaagat tgatagcatc aaggaaggag
     5581 ttgccttggc ccgtcaagtg attgctagag gcaaggccct tgaaaaactc agactgttac
     5641 aggagtacca aaaatgagtc aggaattttt agcacgaatc ttagagcaga aggcgcgtga
     5701 ggtggagcag atgaagctgg agcaaatcca gcctctgcgc cagacctatc gcttggcaga
     5761 atttttgaag aatcatcagg accgcttgca ggtaatcgct gaggtcaaga aagctagccc
     5821 tagtttggga gatatcaatc tcgatgtgga tattgtgcaa caggcccaga cttatgaaga
     5881 aaacggagca gtgatgattt cggtgttgac agatgaggtt ttctttaaag ggcatttgga
     5941 ttatctacgg gaaatttcca gtcaggtaga gattccgacg ctcaacaaag actt
//
LOCUS       DBMVGT010000084         5987 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.084, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000084 DBMVGT010000000
VERSION     DBMVGT010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5987)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5987)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5987
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.084"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..216)
                     /locus_tag="AC0DU4_001878"
     CDS             complement(<1..216)
                     /locus_tag="AC0DU4_001878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR family transcriptional regulator"
                     /protein_id="HIN4237793.1"
                     /translation="MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDM
                     AELEKQGLLEKAHTSSGRMPSVAGFQYY"
     gene            complement(380..889)
                     /locus_tag="AC0DU4_001879"
     CDS             complement(380..889)
                     /locus_tag="AC0DU4_001879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001088691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2812 domain-containing protein"
                     /protein_id="HIN4237794.1"
                     /translation="MNSRVEFRIFTIVDLDKEEEYLHEMHLKGWRYRTSRFGLFYFDQ
                     CQPDDVIYRIYDSRFLKKYKHELQDFRDRGWELIGAGSCSILRKSSSDLLPEDQVYMS
                     KGLKWEVMRSRLRSCTTTFLGGLVVCTSLFREDLSMSFFLIFVLYAFLISYLIHGYFR
                     LKRKYRVDE"
     gene            1496..3829
                     /gene="hsdR"
                     /locus_tag="AC0DU4_001880"
     CDS             1496..3829
                     /gene="hsdR"
                     /locus_tag="AC0DU4_001880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0015666 - restriction
                     endodeoxyribonuclease activity [Evidence IEA];
                     GO_process: GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="EcoAI/FtnUII family type I restriction enzme
                     subunit R"
                     /protein_id="HIN4237795.1"
                     /translation="MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTD
                     GRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAKDNKHSVRAGLQQAIEYGEILDV
                     PFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYY
                     TDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLA
                     KRVLFLADRNILVDQTMAEDFRPFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGE
                     DGTETHYQKFDKDFFDLIVIDEAHRGSAKENSNWRKIIDYFSSATQIGMTATPKETKN
                     ASNTEYFGEPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDANGQLIED
                     RYYGRKDFDKTIVIDDRTQRVAKFVSDYMKQNNARFDKTIVFCVDIDHAERMRAALVK
                     ENLDLVQEDYRYVMQVTGDNAEGKAQLDNFMDVNSNFPAMVTTSKLLTTGVNAKTCRL
                     IVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFFTIIDFRNVTNLFADPDFDGDPVKVLE
                     TGAKTVSGSTPGFVDKEGDPVEKYIVTDKQVTILNSTVQVLDENGKLITESLTDYTRK
                     NILGSYATLNDFITVWHTADKKKLILDELYKKGVYLDAIRESEGISEQEIDDFDLLLK
                     LAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILLNKYMDKGIGELESIETLKLP
                     EFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA"
     gene            3842..5305
                     /locus_tag="AC0DU4_001881"
     CDS             3842..5305
                     /locus_tag="AC0DU4_001881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0008170 - N-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-6 DNA methylase"
                     /protein_id="HIN4237796.1"
                     /translation="MSITSFVKRIQDITRNDAGVNGDAQRIEQMSWLLFLKIYDSREM
                     VWELEEDEYESIIPEELKWRNWAHAQNGERVLTGDELLDFVNNKLFKELKELEITSNM
                     PIRKTIVKSAFEDANNYMKNGVLLRQVINVIDEVDFNSPEDRHSFNDIYEKILKDIQN
                     AGNSGEFYTPRAATDFIAEVLDPKLGESMADLACGTGGFLTSTLNRLSSQRKTSEDTK
                     KYNTAVFGIEKKAFPHLLAVTNLFLHEIDDPKIVHGNTLEKNVREYTNDEKFDIIMMN
                     PPFGGSELETIKNNFPAELRSSETADLFMAVIMYRLKENGRVGVILPDGFLFGEGVKT
                     RLKQKLVDEFNLHTIIRLPHSVFAPYTGIHTNILFFDKTKKTEETWFYRLDMPDGYKN
                     FSKTKPMKSEHFNPVRDWWENREEILEGKFYKSKSFTPSELAELNYNLDQCGFPKEEE
                     EILNPFELIQNYQAERATLNHKIDNVLADILQLLEDK"
     gene            5305..>5987
                     /locus_tag="AC0DU4_001882"
     CDS             5305..>5987
                     /locus_tag="AC0DU4_001882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187262.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HIN4237797.1"
                     /translation="MTPEQLKASILQRAMEGKLVPQNPNDEPASELLKRIKAEKEKLI
                     SEGKIKRDKKETEIFRGDDGKHYGKFADGSTQEIDVPYDIPDTWEWVRIKSIYWNFGQ
                     NKPEKSFRYIDTSSIDRKKNIINYKNLQYLSPEQAPSRARKLVSQNSVLFSTVRPYLK
                     NIAVVRELKEYLIASTAFIVLDTLLNETYLKYYLLSDNFINRVNNKSTGTSYPAINDY
                     NFNLLLIALP"
BASE COUNT         2113 a          967 c         1142 g         1765 t
ORIGIN      
        1 atagtactga aaaccagcaa cacttggcat ccgaccgctt gaagtatgag ccttctcaag
       61 caacccttgt ttttctagtt ccgccatgtc attacgaatg gttgcactgc tagagttaat
      121 agactcttgc aaggcttttg atccgacagg ttcgtgcgtt ttggtaaaga tgtcaataat
      181 cagatttaaa atatcctgct gacgctctgt aaccatctca tcactcctct ctgtctgatc
      241 aattagcact caatgcatcc aagtgctaac ttatgattct attatacacc cttagaagag
      301 aatgtcaaga caaaaactca aaaaattagc actcttttat caagagtgct aaaaatcaat
      361 ctgaagacct agaaccttgc tattcatcta ctcggtattt cctttttagt ctgaaataac
      421 catgaattag ataagaaatc agaaaagcat ataaaacaaa aataagaaag aaagacatag
      481 aaagatcctc tctaaacaaa ctcgtacaaa caacaagacc acctaagaaa gtagttgtac
      541 aggaacgaag tctagatcgc ataacttccc atttgagccc cttactcata tagacttgat
      601 cctctggaag taaatcagaa gacgatttac gaagaatcga acaagaacct gctcctatca
      661 attcccaacc tctatctcta aaatcttgca gttcatgctt atatttttta agaaatctag
      721 aatcatagat acggtagatg acatcgtctg gttgacattg gtcaaaatag aacaaaccaa
      781 aacgactcgt tctatacctc caacctttca aatgcatctc atgtaaatat tcttcttcct
      841 tgtccaaatc aacaatagtg aaaatccgaa attctactct gctattcatt gtcttacccc
      901 aaaattagaa aacatgcctg gcgttattta ttagataatt ctttccgctt ttgactcaat
      961 ctccaaaaaa tataagaaat ctgaatcgca aaaactatca ataaaaccca atctattatg
     1021 aaagtcaaaa acacttccca actgaaagaa ctacctccag tgacaaactt tgagaaaaac
     1081 ggtagtagag ctaaaaagag aagcaaaata ggaagcatcc gcattgttaa aatccttttg
     1141 gcataaaaaa atctttattt aaacgaaaat attatggcaa aatttacgcc agtttttgaa
     1201 cggctgatgt agatatttta tactttcaaa atgtttaaat gtgattattt atttttgaaa
     1261 aatagctcac cagcccgact gaaagtgctt ataaatgata ataagtcgcc tgccgaaaac
     1321 agcgaaaaat agcggtgtta tgcggagata atctgacgcg atgcgaaagt atattgcata
     1381 cttattttca acaatttagc agagtatttt tataagtgtg atataataga agtataattt
     1441 gttctgatag tttattttat ggagaagtag atttttagaa tgcggagggt tcaatatggt
     1501 tgagtttata aagtctaaga aagaaatgag tgaggaggat attaaagcaa atttcatcac
     1561 tcctgctatt gtatccaaag gatggaaaaa tggtgagcat atcgcttacg aagaatactt
     1621 cactgatggt cgaattgagg ttagaggaga taaggctcgt cgtaaagaag gaaaaaaatc
     1681 agactattca ctgtattacc aatttggaac tcgaattgca attgttgagg caaaggataa
     1741 taaacacagc gttcgagcag gattacaaca agctattgaa tatggagaga ttttagatgt
     1801 tccatttgtt tattcttcga atggtgatgg ctttattgaa cacgaccgta tcacgagaga
     1861 agaacgtgag ctggagttag acgaattccc tactcgtgaa gaattatttt ctcgtatgac
     1921 gaaggaaaaa ggattgacgt acgaaattac agaagctatc tcaactccat actatacaga
     1981 cgccttctca atgaaaacgc cacgctatta tcagcaaata gctatcaacc gtactattga
     2041 aacagttgcc agaggacaaa aacgagtaat gtttgtgatg gcaacaggaa cggggaaaac
     2101 gttcatggct tttcaaatta ttcatcgcct tcgaaaagct ggtttggcta aacgagtttt
     2161 attcttagcg gatagaaaca tcttagtaga ccaaacgatg gctgaagact ttaggccatt
     2221 cgaaaaggta atgacgaaaa ttacaccaaa acttttgact gctcctgaaa aattaaattc
     2281 ttttgaaatt tatctagggc tttatcagca actaactggt gaagatggaa ctgaaacaca
     2341 ttatcaaaaa tttgacaaag acttctttga tttaatcgta attgatgaag cgcaccgtgg
     2401 ttcagctaag gaaaacagta actggcgtaa gataattgat tatttcagtt ctgcgacaca
     2461 gattgggatg accgctactc ctaaagaaac caagaatgct tccaatacgg aatactttgg
     2521 tgagccaatc tatacttata gtttaaaaca gggaatcgag gatggttttt tggctccata
     2581 tcgtgttatg agggttaatt tagatgtgga tgtggatggt tatcgtccag aaactggaaa
     2641 agttgatgct aacggacaat taatagaaga taggtactac ggcaggaaag attttgataa
     2701 aaccattgtc attgatgata gaacgcaaag agttgccaag tttgtttctg attatatgaa
     2761 gcaaaacaat gcacgatttg ataaaacaat tgttttttgt gttgatattg accatgccga
     2821 gcgaatgcgt gctgcacttg taaaagagaa tctagactta gtccaagaag actatcgtta
     2881 tgtcatgcaa gtaactggtg acaacgctga aggaaaagct caactggata actttatgga
     2941 tgtcaattct aattttcccg ctatggtaac aacgtctaaa ttattaacga caggagttaa
     3001 tgctaaaaca tgtcgtttga ttgttttaga ctctaatatc caatccatga ctgaatttaa
     3061 acaaattatt ggtcgtggca cacgtcttta tcctcaaaag gggaaagaat tttttacgat
     3121 tattgatttt cgaaatgtta ccaatttgtt tgctgaccct gattttgatg gtgatcctgt
     3181 gaaggtgctg gaaacaggtg cgaaaacagt cagtggttct acgcccggtt tcgtagataa
     3241 ggaaggtgac ccagtagaaa aatatatcgt tacagacaag caggttacca ttcttaattc
     3301 tactgttcaa gtattggatg aaaacgggaa actgattacc gaaagcctga ccgactacac
     3361 tcggaagaat atcttaggta gctacgccac tttgaacgat tttatcacag tttggcatac
     3421 ggcggataaa aagaagctta tcttagacga actttataaa aaaggagttt atctagatgc
     3481 tattcgagag tcggagggaa tatcagaaca agaaatcgat gattttgatt tactcctaaa
     3541 acttgcctat ggtcaaaaag aattaaccaa aacggaacgt atcaataaac tcaaacaaag
     3601 cggatattta tataaatata gtgaggaagc gcgtgctgtt ttggaaattt tactgaacaa
     3661 atacatggat aaaggtattg gagaactcga aagcattgaa acattaaaac ttccagaatt
     3721 tcagatatat ggtggaacct tcaaaatcat caatacttat tttggagata aaaaacgata
     3781 tttacaagca attaaagaat tggagcaaga gctatttaca gtagcttaat gaaaggaaag
     3841 tatgtcaatt acatcatttg taaaaagaat tcaagatatc actcgaaacg atgctggtgt
     3901 taatggtgat gctcaacgta ttgagcaaat gtcttggtta ttattcttaa aaatttatga
     3961 tagccgtgaa atggtttggg aattagaaga agacgagtat gagtcaatta tcccagagga
     4021 attaaaatgg cgaaattggg ctcatgctca aaatggggaa cgggtattga caggcgatga
     4081 attacttgat tttgtcaata acaagttatt caaagagttg aaagagcttg aaataacttc
     4141 aaatatgcct attcgaaaaa cgattgttaa atcagctttt gaagatgcga acaactatat
     4201 gaaaaatggc gtcttgttac gccaagtcat caatgttatt gatgaagttg atttcaatag
     4261 ccctgaagat cgtcattcgt ttaatgatat ttacgaaaaa attcttaaag atattcaaaa
     4321 tgctgggaac tcaggagaat tttatacgcc acgtgcagcg actgatttta ttgccgaagt
     4381 tcttgaccca aaacttggag aatcaatggc agaccttgct tgcggaacag gaggcttctt
     4441 gacttcgact ctgaaccgtt taagtagtca acgtaaaact agtgaagata ccaaaaaata
     4501 taatacagct gtttttggta ttgaaaagaa agcatttcct catcttttag cagttacaaa
     4561 tctgtttctt cacgaaattg atgaccctaa aattgttcat ggaaatactt tggagaaaaa
     4621 tgttcgtgaa tatacgaatg atgaaaaatt tgacattatt atgatgaatc caccttttgg
     4681 agggtcagaa ttagaaacaa taaaaaataa ctttccagca gaattacgga gttctgaaac
     4741 agctgattta tttatggctg tcattatgta tcgtttgaaa gaaaatggtc gtgttggagt
     4801 tattttacct gatggttttc tatttggtga aggtgtaaaa actcgcttga aacaaaaact
     4861 ggtagatgag ttcaacttgc atacgattat taggttgcct catagtgtct ttgcaccgta
     4921 tacaggaatc catacgaaca ttcttttctt tgataaaaca aagaaaacag aagaaacttg
     4981 gttttatcgt ttagatatgc cagatggtta taaaaatttc tcgaaaacta agccgatgaa
     5041 gtcagaacac ttcaatcctg ttcgtgactg gtgggaaaat cgtgaagaga ttctggaagg
     5101 taagttctac aaatctaaat catttacacc tagtgaattg gctgagttga attataattt
     5161 agaccagtgt ggttttccaa aagaggaaga ggaaatctta aatccctttg agttgattca
     5221 gaattatcaa gcggaaagag caactttaaa tcataagatt gataatgtat tagctgatat
     5281 tttgcagttg ttggaggaca aataatgaca ccagaacaac ttaaagcaag tattctccaa
     5341 agagcgatgg aagggaaatt agtgccgcaa aatcccaatg acgaacctgc aagtgaatta
     5401 ttaaagagaa ttaaagctga aaaagaaaaa cttatcagtg aaggaaaaat caaacgagat
     5461 aaaaaggaaa ctgagatatt tcgtggtgat gatgggaaac attatgggaa gtttgctgat
     5521 ggaagcactc aagaaattga tgttccttat gatattcctg atacttggga gtgggtgagg
     5581 ataaaatcaa tttattggaa ttttgggcaa aataagccag agaaatcctt taggtatata
     5641 gatacgtcta gtattgatag aaaaaagaac ataatcaact acaaaaatct acaatatctt
     5701 tcacctgaac aagcgccttc ccgtgctaga aaattagttt cgcagaatag tgtcttattt
     5761 tcaacagtta gaccatatct aaaaaatatt gctgtagtta gagaacttaa agagtatttg
     5821 atagctagta cagcatttat tgttttggat actttactta acgaaacata tttgaaatat
     5881 tatttattat cagataattt tatcaatcgt gttaataata aatctactgg aacaagttat
     5941 cctgcaatca atgattataa ttttaatcta ttattaattg ctctccc
//
LOCUS       DBMVGT010000085         5875 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.085, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000085 DBMVGT010000000
VERSION     DBMVGT010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5875)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5875)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5875
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.085"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1563
                     /locus_tag="AC0DU4_001883"
     CDS             <1..1563
                     /locus_tag="AC0DU4_001883"
                     /EC_number="3.2.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-galactosidase"
                     /protein_id="HIN4237798.1"
                     /translation="FLQIAQDLGLYAIVRPSPFICAEWEFGGLPAWLLTKNMRIRSSD
                     PAYIEAVGRYYDQLLPRLVPRLLDNGGNILMMQVENEYGSYGEDKAYLRAIRQLMEER
                     GVTCPLFTSDGPWRATLKAGTLIEEDLFVTGNFGSKAPYNFSQMQEFFDEHGKKWPLM
                     CMEFWDGWFNRWKEPIITRDPKELADAVREVLEQGSINLYMFHGGTNFGFMNGCSARG
                     TLDLPQVTSYDYDALLDEEGNPTAKYLAVKKMMATHFSEYPQLEPLYKESMELDAIPL
                     VEKVSLFETLDSLSSPVESLYPQKMEELGQSYGYLLYRTETNWDAEEERLRIIDGRDR
                     AQLYVDGQWVKTQYQTEIGEDIFYQGKKKGLSRLDILIENMGRVNYGHKFLADTQRKG
                     IRTGVCKDLHFLLNWKHYPLPLDNPEKIDFSKGWTQGQPAFYAYDFTVEEPKDTYLDL
                     SEFGKGVAFVNGQNLGRFWNVGPTLSLYIPHSYLKEGANRIIIFETEGQYKEEIHLTR
                     KPTLKHIKGENL"
     gene            1560..2036
                     /locus_tag="AC0DU4_001884"
     CDS             1560..2036
                     /locus_tag="AC0DU4_001884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HIN4237799.1"
                     /translation="MTIVGCRIDGRLIHGQVANLWAGKLNVSRIMVVDDEVVNNDIEK
                     SGLKLATPPGVKLSILPVEKAAANILAGKYDSQRLFIVARKPDRFLGLVEAGVPLETL
                     NVGNMSQTPETRSITRSINVVDKDVEDFHKLAEKGVKLTAQMVPNDPISDFLSLLK"
     gene            2064..2969
                     /locus_tag="AC0DU4_001885"
     CDS             2064..2969
                     /locus_tag="AC0DU4_001885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HIN4237800.1"
                     /translation="MIQWWQILLLTLYSAYQICDELTIVSSAGSPVFAGFITGLIMGD
                     VTTGLLIGGNLQLFVLGVGTFGGASRIDATSGAVLATAFSVSQGIDAPLAITTIAVPV
                     AALLTYFDVLGRMTTTFFAHRVDAAIERFDYKGIERNYLLGAIPWALSRALPVFFALA
                     FGGAFVQSVVDFVEAYKWVADGLTLAGRMLPGLGFAILLRYLPVKRNLHYLAMGFGLT
                     AMLTVLYSYVTGLGGAVAGIVGTLPAEVAEKIGFVNNFKGLSMIGISIVGIFLAVLHF
                     KNSQKVAVAAPSTPSESGEIEDDEF"
     gene            2956..3771
                     /locus_tag="AC0DU4_001886"
     CDS             2956..3771
                     /locus_tag="AC0DU4_001886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HIN4237801.1"
                     /translation="MTNSNYKLTKEDFNQINKRSLFTFQLGWNYERMQASGYLYMILP
                     QLRKMYGDGTPELKEMMKVHTQFFNTSPFFHTIIAGFDLAMEEKDGVGSKDAVNGIKT
                     GLMGPFAPLGDTIFGSLVPAIMGSVAATMAIAGQPWGIFLWIAVAVAYDIFRWKQLEF
                     AYKEGVNLINNMQSTLTALIDAASVLGVFMMGALVATVINFEISYKLPIGEKMIDFQD
                     ILNQIFPRLLPAIFTAFIFWLLGKKGMNSTKAIGIIIVLALALSALGHFALGM"
     gene            3778..4182
                     /locus_tag="AC0DU4_001887"
     CDS             3778..4182
                     /locus_tag="AC0DU4_001887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007284837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HIN4237802.1"
                     /translation="MTKSLILVSHGRFCEELRGSTEMIMGPQDNIYTVALLPEDGPEE
                     FTAKFEAVIEGLDDFLVFADLLGGTPCNVVSRLIMEGRDIDLYAGMNLPMVIEFINAS
                     LTGADADYKSRAAESIVKVNDLLAGFDDDEDE"
     gene            4481..5641
                     /locus_tag="AC0DU4_001888"
     CDS             4481..5641
                     /locus_tag="AC0DU4_001888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000903564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA];
                     GO_process: GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HIN4237803.1"
                     /translation="MLHYTKEDLLELGAEITTREIYQQPDVWREAFEFYQAKREEIAA
                     FLQEIADKHDYIKVILTGAGTSAYVGDTLLPYFKEVYDERKWNFNAIATTDIVANPAT
                     YLKKDVATILVSFARSGNSPESVATVDLAKSLVDELYQVTITCATDGKLALQAHGDDR
                     NLLLLQPAVSNDAGFAMTSSFTSMMLTALLVFDPTEFAVKSERFEVVSSLARKVLDKA
                     EDVKELVDLDFNRVIYLGAGPFFGLAHEAQLKILELTAGQVATMYESPVGFRHGPKSL
                     INDNTVVLVFGTTTDYTRKYDLDLVREVAGDQIARRVVLLSDQAFGLENVKEVALGCG
                     GVLNDIYRVFPYIVYAQLFALLTSLKVENKPDTPSPTGTVNRVVQGVIIHEY"
     gene            5763..>5875
                     /locus_tag="AC0DU4_001889"
     CDS             5763..>5875
                     /locus_tag="AC0DU4_001889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose epimerase"
                     /protein_id="HIN4237804.1"
                     /translation="MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGAT"
BASE COUNT         1601 a         1150 c         1331 g         1793 t
ORIGIN      
        1 tttctccaaa tagcgcagga tttgggtctc tacgcaattg tgcgtccgtc tccatttatc
       61 tgtgcggaat gggaattcgg tggcttacca gcttggctct tgaccaagaa catgcgaatt
      121 cgctcatccg acccagcata tatcgaggca gttggtcgct actatgatca gttattgcca
      181 agactggtgc ctcgtttgtt ggacaatggt ggcaatattc tcatgatgca ggttgaaaat
      241 gagtatggtt cttacggaga agataaggct tacctgagag cgattcgaca gctaatggaa
      301 gagcgtggcg taacctgtcc tctctttaca tcagatggtc catggcgagc tactctgaaa
      361 gctggaacct taattgaaga ggacctcttt gtaacaggaa actttggttc taaggcacct
      421 tacaactttt cgcagatgca ggaattcttt gatgaacatg gtaagaaatg gccactcatg
      481 tgtatggagt tctgggatgg ttggtttaat cgctggaaag aaccgattat cacacgggat
      541 cctaaggaat tggcagatgc agttcgagag gttttggaac aaggctctat caatctttac
      601 atgttccacg gtggtacaaa ctttggtttc atgaatggtt gctcggctcg aggaactttg
      661 gacctgccac aagttacgtc ttatgattac gatgcccttc tggatgaaga aggaaatcca
      721 actgctaaat atcttgcagt caagaagatg atggcaacac atttttcaga gtatccgcag
      781 ttggaaccac tctacaaaga gagtatggag ttggatgcta ttccactagt tgaaaaagtt
      841 tctttgtttg aaaccttaga tagcttgtca agtcctgtag aaagtctcta tcctcaaaag
      901 atggaggagc tgggacaaag ttatggctac ctactttatc gaacagaaac aaactgggat
      961 gcagaagaag aaagacttcg tatcattgat ggtcgagata gggcccagct gtatgtcgat
     1021 ggtcagtggg ttaaaactca atatcagaca gagattgggg aagatatttt ttatcaaggt
     1081 aaaaagaaag ggctatctag gttagatatc ttgatagaaa atatggggcg tgtcaactat
     1141 gggcataagt tcttagcgga tacgcaacgt aagggaattc ggacaggggt ctgtaaggat
     1201 ctgcatttct tactaaactg gaaacactat ccacttccac tagacaatcc tgagaaaatt
     1261 gatttttcaa aaggatggac tcaaggacaa ccagcctttt acgcttatga ctttacagtc
     1321 gaagagccaa aagatactta cctagacttg tctgagtttg gtaagggagt tgcctttgtc
     1381 aatgggcaga atctaggacg tttttggaac gttggcccaa ctctctcact ttatatccct
     1441 catagctatc tcaaggaagg tgccaaccgc atcattatct ttgaaacaga aggtcaatat
     1501 aaagaagaga ttcatttaac tcgtaaacct acactaaaac atataaaggg ggaaaactta
     1561 tgacaattgt aggatgccgt attgatggac gtttgatcca cggacaagta gccaatcttt
     1621 gggctggaaa actaaatgtt tcacgcatta tggttgtaga cgacgaagtt gtcaacaacg
     1681 atattgaaaa gagtggtttg aaacttgcga caccaccagg tgtgaaattg agtattttgc
     1741 cagttgagaa agctgcagcc aatattcttg ctggtaaata cgatagccaa cgtctcttta
     1801 tcgtggctcg taaaccagac cgcttccttg gcttggtaga agcaggtgta ccacttgaaa
     1861 cccttaatgt tgggaatatg tctcaaacac cagaaactcg ttctattaca cgttctatca
     1921 acgtagtaga caaggatgtg gaagacttcc acaaactggc agaaaaaggt gttaaactta
     1981 ctgctcagat ggttccaaat gatccaattt cagacttttt gagcttatta aaataggaaa
     2041 aaaattttta ggaggtcatt gttatgatac aatggtggca aattttactt ctcactttgt
     2101 actcagctta tcaaatctgt gatgagttga cgatcgtttc atctgcaggt tcccctgtat
     2161 ttgctggttt cattactggt ttaatcatgg gagatgtgac tactggttta cttatcggtg
     2221 gtaacttgca actgttcgtt cttggggttg gtaccttcgg tggtgcttct cgtatcgacg
     2281 caacttctgg tgcggttctt gcgacagcct tctctgtttc acaaggaatt gatgcaccgc
     2341 ttgccattac tacaatcgct gtaccagtag cagctctctt gacttacttc gacgttcttg
     2401 gtcgtatgac tactaccttc ttcgctcacc gtgtggatgc tgcaatcgaa cgctttgact
     2461 ataaaggtat tgaacgcaac tacttgcttg gtgcgattcc gtgggctcta tctcgtgccc
     2521 ttccagtctt ctttgccctt gcttttggtg gtgcctttgt acaatcagta gtagacttcg
     2581 ttgaagccta caaatgggtt gcagatggct tgacacttgc aggacgtatg cttccaggtc
     2641 ttggatttgc aatcttgctt cgttaccttc cagttaaacg taaccttcac taccttgcta
     2701 tgggatttgg tttgacagct atgttgactg ttctttactc atatgtaaca ggtcttggtg
     2761 gcgctgttgc tggtatcgta ggtactcttc ctgctgaagt tgctgaaaaa attggtttcg
     2821 tgaacaactt caaaggtttg tctatgattg gtatttctat cgtaggtatt ttccttgcag
     2881 tgcttcactt caaaaatagc caaaaagtag ctgtagcagc accttctaca ccatcagaaa
     2941 gtggggaaat cgaagatgac gaattctaat tacaaactta caaaagaaga ttttaatcaa
     3001 atcaacaaac gtagcttgtt tactttccaa ttaggttgga actacgaacg tatgcaagct
     3061 tctggttacc tttacatgat cttgcctcag ttgcgtaaaa tgtatggtga tggaactcct
     3121 gaattgaaag aaatgatgaa agttcatact caattcttca atacttcacc attcttccat
     3181 accattatcg ctggttttga ccttgccatg gaagaaaaag atggtgtagg ttcaaaagac
     3241 gctgttaacg gtatcaagac aggtttgatg ggaccattcg ctcctcttgg ggatacaatc
     3301 tttggttcac ttgtacctgc tatcatgggg tcagtcgcag caactatggc tatcgctggc
     3361 caaccttggg ggatcttcct ttggattgca gttgcagtag cgtatgacat cttccgttgg
     3421 aaacagttgg aatttgctta caaagaaggg gttaacctta tcaacaacat gcaaagtacc
     3481 ttgacagctt tgattgacgc tgcatctgta cttggtgtct tcatgatggg tgctcttgta
     3541 gcaacagtga ttaactttga aatttcttac aagttgccaa tcggtgaaaa gatgattgat
     3601 ttccaagaca tcttgaacca aatcttccca cgtttgcttc cagcaatctt tactgccttt
     3661 atcttctggt tgcttggtaa gaaaggtatg aactctacta aagctatcgg tattattatc
     3721 gtacttgctt tggctctttc tgcccttggt cactttgcac ttggaatgta attccttatg
     3781 actaaatcat taattttggt gagccatggt cgcttctgtg aggagcttag aggtagcaca
     3841 gaaatgatta tgggcccaca agacaacatt tacacagtag ctcttcttcc agaagatggc
     3901 ccagaagaat ttactgctaa atttgaagct gttattgaag gattggatga tttcctagtt
     3961 tttgcggatc ttctcggtgg gacaccttgt aatgtggtga gtcgcttgat catggaaggt
     4021 cgtgatattg acctttacgc agggatgaat cttccaatgg tgattgaatt tatcaatgcg
     4081 agccttacag gcgcagatgc ggactacaag agccgtgctg cagaaagcat tgtgaaagtt
     4141 aatgacctgt tagcgggctt cgatgatgac gaagatgaat aatactcttc gaaaatctct
     4201 tcaaactacg tcaacgtcgc cttaccgtag gtatatgtta ctgacttcgt cagtcttatc
     4261 cggcaacctc aaaacggtgt tttgagctga cttcgtcagt cttatccggc aacctcaaag
     4321 cagtgctttg agcagcctgc ggctagtttc ctacagattt tagttggaac tcgattcaat
     4381 tcatgtgaca acgtgaaaat cgttagagca ttttatatag aatatacatg ggaatggagc
     4441 ttactcccat tcctatattt aatagaaaaa gaggaactca atgctacatt atacaaaaga
     4501 agacttgctc gaattgggtg cagaaatcac tacgcgtgaa atctaccaac agcctgatgt
     4561 atggagagaa gcttttgaat tttatcaagc aaaacgtgaa gaaattgcag ccttcctaca
     4621 agaaatcgct gataaacatg actatattaa ggttatcttg acaggtgctg ggacttctgc
     4681 ttatgtggga gacaccttgc taccttactt taaggaagtc tatgacgaac gcaaatggaa
     4741 tttcaatgct attgcgacaa cagatatcgt tgccaatcca gcaacctatt tgaaaaaaga
     4801 tgtggcaact atccttgtgt cttttgctcg tagtgggaac tcgcctgaaa gtgtggcgac
     4861 tgttgatttg gccaaatcct tggtggatga gctttatcaa gtgacgatta cttgtgcaac
     4921 agatggtaaa ttggctcttc aagctcacgg tgatgaccgt aatctcttgc tcttgcaacc
     4981 agctgtctct aatgatgctg gatttgccat gacttctagc tttacgtcta tgatgttgac
     5041 agctctcttg gtctttgatc ctacagaatt tgctgttaag tctgaacgtt ttgaagttgt
     5101 atctagtctt gcccgtaaag ttttagacaa ggcagaagat gtcaaagagc tcgttgattt
     5161 agactttaac cgtgtcatct atctaggcgc tggtcctttc tttggacttg ctcatgaagc
     5221 tcagctcaag attttggaat taactgctgg tcaagttgcg accatgtatg aaagcccagt
     5281 tggcttccgt cacggtccaa aatctcttat caacgacaat acagttgttt tggtctttgg
     5341 tacaacgaca gactacactc gtaagtacga cttggacttg gttcgtgaag ttgctggtga
     5401 ccagattgct cgtcgtgttg tgcttttgag tgatcaagct tttggtcttg aaaatgtcaa
     5461 agaagtggcc cttggttgtg gcggtgtctt gaatgatatt taccgtgtct tcccttacat
     5521 cgtttatgcc caactctttg ccctattgac ttcactcaag gtagaaaata aaccagatac
     5581 accgtctcct acaggtacag taaaccgtgt agtacaaggt gtcataattc acgaatatta
     5641 aaagtaagac agtgtttatg aattcttgac aagaggattt gtaaattatc agataaacca
     5701 tagattgtca gtacgctttc tatggtttgt ttgcttgaga gaaatagtaa aaggagaaca
     5761 gaatgaaagc atacacagag cgtgtatttg gaaatgttga gggcgaggat gtcttggcct
     5821 atcgatttga gacagacggt ggctaccaac ttgaggttat gacttatggc gcgac
//
LOCUS       DBMVGT010000086         5826 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.086, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000086 DBMVGT010000000
VERSION     DBMVGT010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5826)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5826)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5826
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.086"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..745
                     /locus_tag="AC0DU4_001890"
     CDS             <1..745
                     /locus_tag="AC0DU4_001890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001063457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HIN4237805.1"
                     /translation="GVGKTELAKQLALDMFGTQDAIIRLDMSEYSDRTAVSKLIGTTA
                     GYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVN
                     FKNTVIIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKED
                     LSKIVDLMLAEVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRPLRRVVEQEIRDK
                     VTDFHLDHLDAKHLEADMEDGVLVIREKA"
     gene            complement(1041..1523)
                     /locus_tag="AC0DU4_001891"
     CDS             complement(1041..1523)
                     /locus_tag="AC0DU4_001891"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HIN4237806.1"
                     /translation="MSKEVIVESFELDHTIVKAPYVRLIGEETGPKGDIISNYDIRLV
                     QPNEDSIPTAGLHTIEHLLAKLIRTRIDGMIDCSPFGCRTGFHMIMWGRHTSAKIAAV
                     IKDSLKEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILEQGISDDAFERHVI
                     "
     gene            complement(1618..3102)
                     /locus_tag="AC0DU4_001892"
     CDS             complement(1618..3102)
                     /locus_tag="AC0DU4_001892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HIN4237807.1"
                     /translation="MKKQAFSSEQYLNLQRDHILERINQFDGKLYLEFGGKMLEDFHA
                     ARVLPGYEPDNKIKLLQELKEQVEVVIAINASNIEHSKARGDLGISYDQEVLRLIDKF
                     NELGIFVGSVVITQYAGQPAADAFRNQLEKNGIDSYLHYPIKGYPTDMDHIISPGGMG
                     KNDYIKTSRNLIVVTAPGPGSGKLATCMSNMYHDQINGIKSGYAKFETFPVWNLPLHH
                     PVNLAYEAATADLDDVNMIDPFHLQTYGETTVNYNRDIEIFPVLKRMSERILGKSPYA
                     SPTDMGVNMVGFAITDDEAAVEASKQEIIRRYYQTVLDFKAEKVGEAAVKKIELLMND
                     LGITPADRKVAVVARQKAEETGGPALAFELPNGEIVTGKNSELFGPTAAALINAIKKS
                     ADIAKEVKLIEPEVVKPIQGLKIDHLGSRNPRLHSNEILIALAITATENPDAARAMEE
                     LGNLKGSEAHSTIILTDEDKNVLRKLGINVTFDPYYQYDRLYRK"
     gene            3255..4862
                     /locus_tag="AC0DU4_001893"
     CDS             3255..4862
                     /locus_tag="AC0DU4_001893"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_function: GO:0004556 - alpha-amylase activity [Evidence
                     IEA];
                     GO_function: GO:0004574 - oligo-1,6-glucosidase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0009311 - oligosaccharide metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 13 protein"
                     /protein_id="HIN4237808.1"
                     /translation="MQEKWWHNAVVYQVYPKSFMDSNGDGVGDLPGITSKLDYLAKLG
                     ITAIWLSPVYDSPMDDNGYDIADYQAIAAIFGTMEDMDQLIAEAKKRDIRIIMDLVVN
                     HTSDEHAWFVEACENTDSPERDYYIWRDEPNDLDSIFSGSAWEYDEKSGQYYLHFFSK
                     KQPDLNWENEKLRQKIYEMMNFWIDKGIGGFRMDVIDMIGKIPDEKVVNNGPMLHPYL
                     KEMNQATFGDKELLTVGETWGATPEIAKLYSDPKGQELSMVFQFEHIGLQYQEGQPKW
                     HYQKELNIAKLKEIFNKWQTELGVEDGWNSLFWNNHDLPRIVSIWGNDQEYREKSAKA
                     FAILLHLMRGTPYIYQGEEIGMTNYPFETLDQVEDIESLNYAREALEKGVPIEEIMDS
                     IRVIGRDNARTPMQWDESKNAGFSTGQPWLAVNPNYEMINVQEALANPDSIFYTYQKL
                     VQIRKENSWLIRADFELLDTADKVFAYIRKDGDRRFLVVANLSNEEQDLTVEGKVKSV
                     LIENTLAQEVFEKQILVPWDAFCVELL"
     gene            5027..5194
                     /locus_tag="AC0DU4_001894"
     CDS             5027..5194
                     /locus_tag="AC0DU4_001894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001022221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteinase"
                     /protein_id="HIN4237809.1"
                     /translation="MKKRILSAGLTFTSDLLLAACGQSGSDTKTYSSTFSGNPTTFNY
                     LLDYYADNIVN"
     gene            complement(5187..5826)
                     /locus_tag="AC0DU4_001895"
                     /pseudo
     CDS             complement(5187..5826)
                     /locus_tag="AC0DU4_001895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="IS630 family transposase"
BASE COUNT         1699 a         1110 c         1319 g         1698 t
ORIGIN      
        1 tggggttggt aagacggagc ttgctaagca attggcactc gatatgtttg gaacccagga
       61 tgcgattatc cgtttggata tgtctgaata cagtgaccgc acagctgttt ctaagctaat
      121 tggtacaaca gcaggctatg tgggttatga tgacaatagc aataccttaa cagaacgtgt
      181 tcgtcgcaat ccatactcta tcattctctt ggatgaaatt gaaaaggctg accctcaagt
      241 tattaccctt ctcctccaag ttctagatga tggtcgtttg acagatggtc aaggaaatac
      301 agtaaacttc aagaacactg tcattattgc gacctcaaat gctggatttg gctatgaagc
      361 caacttgaca gaagatgcgg ataaaccaga attgatggac cgtttgaaac ccttcttccg
      421 tccagaattc ctcaaccgct ttaatgcagt catcgagttc tcacacttga ctaaggaaga
      481 cctttctaag attgtagatt tgatgttggc tgaagttaac caaaccttgg ctaagaaaga
      541 cattgacttg gtagtcagtc aagcggctaa agattatatc acagaagaag gttacgacga
      601 agtcatgggg gttcgtcctc tccgtcgagt ggttgaacaa gaaattcgtg ataaggtgac
      661 agacttccac ttagatcatt tagatgctaa acatctggaa gcagatatgg aagatggcgt
      721 tttggttatt cgtgagaaag cctaagatag aattttgagg ataaaaaaga aggagccagc
      781 tgaaaaaaac tggttccttt tgaggtacga cgggcatgtc gtacagtaga agtgtactat
      841 tctagtttca atccactata gtagctcaga agtcggtact taaacgtgct atatcaaaac
      901 cagtccttga aaaacgtgga ttggtttcgt gtttggatta ttaccttgaa cgacatgcgt
      961 taaaagttag ttgaaccgcc gtatgccgaa cggcacgtac ggtggtgtga gaggggctag
     1021 agattatccc ctactcgatt ttaaatcaca tgacgttcaa aggcatcatc tgaaatccct
     1081 tgttccaaga tgagttttgc ccattcttta gcagagaaga ggctgtggtc cttgtagttt
     1141 ccgcaagatt cgatggttgt ccctgggaca tcttcccaag tagtagtttc agcgatttcc
     1201 ttgagcgaat ccttgataac agctgcgatt ttagcactgg tgtgacgtcc ccacataatc
     1261 atgtggaagc ctgtgcggca accaaatggt gaacagtcaa tcatgccgtc aatgcgggta
     1321 cggatgagtt tggctaagag gtgctcgata gtgtgaaggc cggcagtagg gatagagtct
     1381 tcgtttggtt gcaccaagcg aatatcataa ttggagatga tgtctccttt tggtcctgtt
     1441 tcttccccaa tcaagcgaac atagggtgct ttgacaatgg tgtggtcaag ttcaaaactt
     1501 tcgacaataa cttcttttga catggtaaat cctttcagtt ttcttctctc attatatcat
     1561 aaaggttgtt cctgagacag agagaaaacc tctccgaggc tagagaggtt gaaatcttta
     1621 cttacgatat aagcggtcgt attggtagta tgggtcaaag gttacgttga tacccagttt
     1681 acgaaggaca ttcttgtctt catcagtcaa gatgatggtt gagtgggctt cgcttccttt
     1741 gaggttgcct agttcttcca tagcgcgggc agcatcagga ttttctgtag ctgtgatagc
     1801 aagtgcaatc aggatttcat ttgaatgaag gcgtggattg cggctaccga gatgatcgat
     1861 tttaagacct tggattggct taacaacttc aggttcgatt agttttactt ctttagcgat
     1921 gtcagctgat tttttgatgg cgttgatcaa ggcagcggct gtaggaccaa agagttctga
     1981 gttcttacca gtgacgattt ccccatttgg caattcaaag gctagggctg gtccaccagt
     2041 ttcttctgct ttttggcgcg caacgacagc aaccttacgg tctgcaggtg tgataccgag
     2101 gtcgttcatg agcaactcaa ttttcttgac ggcagcttcg ccaacttttt cagctttgaa
     2161 gtcaagaact gtttgatagt aacggcggat gatttcttgt ttagaagctt cgacagcggc
     2221 ctcgtcatct gtaatagcga aaccaaccat gttgacaccc atatctgtcg gtgaagcgta
     2281 tggtgatttt ccgagaatac gttccgacat gcgtttgagc actgggaaga tttcgatatc
     2341 acggttgtag ttgacagtgg tttctccata ggtttgaaga tggaaggggt caatcatgtt
     2401 gacatcatca aggtcagctg tggcagcttc ataagccaag ttaactggat gatgaagggg
     2461 aagattccaa acagggaagg tttcaaattt agcgtagcca gatttgatgc cattgatttg
     2521 gtcgtggtac atattggaca tacacgttgc caattttcca gaaccgggtc caggagcggt
     2581 tacgacaatc aagttgcgac tggttttgat gtagtcgttt ttgcccatgc ctcctgggga
     2641 aatgatgtga tccatatccg taggatatcc tttgattgga taatgaagat aagaatcaat
     2701 tccgtttttc tcaagttggt tgcggaaggc atctgcagcg ggttggccag cgtattgtgt
     2761 aatgacaacg gaaccaacaa aaatccctaa ttcattgaat ttgtcaatca aacgaagaac
     2821 ttcttggtca taagaaatgc ctaagtcgcc acgtgctttg gaatgttcaa tgttgctagc
     2881 attaatggca atcacaacct caacctgctc tttcaattct tgcaagagct tgattttgtt
     2941 gtcaggttca taaccaggaa ggacacgagc agcgtggaaa tcttctaaca ttttaccgcc
     3001 aaactctaag tagagcttgc cgtcaaattg gttaatgcgc tccaaaatat ggtcgcgttg
     3061 taaattcaaa tactgttcag aactaaaagc ttgttttttc atttttttac ctctggactc
     3121 tattataata aaaaattgga agttaggaaa ctacggagct aaaaaagaaa ttaaaaagat
     3181 taagcaaacg cttgcacaaa attttaaaaa gtgctatcat agactataga ttattaaaat
     3241 aatgaggtaa acagatgcaa gaaaaatggt ggcataatgc cgtagtctat caagtctatc
     3301 caaagagttt tatggatagt aatggagatg gagttggtga tttgccaggt attaccagta
     3361 agttggacta tctagctaag ttaggaatca cagcgatttg gctttctccc gtttatgaca
     3421 gccctatgga tgataatggc tacgatattg ctgattatca agcgattgcg gctatttttg
     3481 gaaccatgga ggacatggat cagctgattg cagaagctaa gaagcgtgat atccgtatca
     3541 tcatggactt ggtggtcaat catacctcgg atgagcatgc ttggtttgtc gaagcctgtg
     3601 aaaatactga cagccctgag cgagactact atatctggcg cgatgaaccc aatgacctag
     3661 attctatctt tagtgggtct gcttgggaat acgatgaaaa gtcaggtcaa tactatctcc
     3721 actttttcag caagaaacag ccggatctca actgggaaaa tgaaaaactt cgccagaaaa
     3781 tttatgagat gatgaacttc tggattgata aaggtattgg tggtttccgt atggatgtta
     3841 ttgacatgat tggcaaaatt cctgacgaga aggtagtcaa taatggtcct atgctccatc
     3901 cctatctcaa ggaaatgaat caggcgacct ttggagataa ggagctcttg acagtagggg
     3961 agacttgggg agcaacgcca gagattgcca agctctactc tgatccaaag gggcaagaat
     4021 tgtctatggt cttccagttt gaacatatcg gtcttcagta tcaggaaggt cagcctaaat
     4081 ggcactatca aaaagagctg aatatcgcta agttaaaaga aatcttcaac aaatggcaga
     4141 cagagttagg agttgaggac ggctggaatt ccctcttctg gaacaaccat gacctccctc
     4201 gtattgtctc aatctgggga aatgaccaag aataccgcga aaaatctgcc aaagcctttg
     4261 caatcttact tcatctcatg agaggaactc cttatatcta ccaaggtgag gagattggga
     4321 tgaccaacta tccgtttgaa acactggatc aagtagaaga tattgaatcc ctcaactatg
     4381 cgcgtgaggc tcttgaaaaa ggtgttccga ttgaagaaat catggacagt atccgtgtta
     4441 ttggacgtga caatgcccgt acccctatgc aatgggacga gagcaaaaac gctggtttct
     4501 caacaggtca accttggttg gcggttaatc caaattacga gatgatcaac gtccaagaag
     4561 cgctggcaaa tccagattct attttctata cctatcagaa actggtccaa attcgcaagg
     4621 agaatagctg gctaattcga gctgactttg aattgcttga tacggctgat aaggtctttg
     4681 cttatatacg taaggatggc gaccgtcgct tcctagttgt ggctaacttg tctaatgaag
     4741 agcaagactt gacagtagaa ggaaaagtca aatctgtctt gattgaaaac accctagctc
     4801 aagaagtctt tgaaaaacaa atcttagttc catgggatgc tttctgtgtg gaattactat
     4861 aaatattttt tgcagaaaaa tttaaaattg aaatcgtata aaaacaaggg aggactgtat
     4921 aaaaggcaga aatcctttgt tttttataac caaggtttat aaaccttcat tctcgaaatt
     4981 caattaactt tacaaattcc cactattaag gagaaagaag acgaacataa agaagcgtat
     5041 ccttagtgca ggcctgactt ttacatctga tttgctttta gctgcttgcg gccaatcagg
     5101 ttcagataca aaaacttact catcaacctt tagtggaaat ccaactacat ttaactatct
     5161 attagactat tacgctgata atatagtcaa ttgaaacaag aacaggacaa aagagcctca
     5221 taaaaggtat tgcaacttgg taataccttt ttgaggtgct ttttgatatg agcccatgtt
     5281 ttctcaatag gattgtactc aggcgagtag ggaggaagag gtaaaagttt atgcccaaac
     5341 tcttcacaca agagttctag cttccccatt ctatggaatc ttgcattatc cataataata
     5401 accgatggtg tggttaatgt tggtaagaga aacttctgaa accaagcttc aaaaaagtcg
     5461 ctcgtcatca tctcttcgta agtcattgga gcgattaact caccattcat ttgttagacc
     5521 tgcaaccaaa gaaatcctct gatatcttct tccagatact ttacctcttc ttaactgacc
     5581 ttttaatgag cgaccatatt ctcgatgaaa ataagtatcg aatcctgttt catcaatcta
     5641 aacaggtgct aggtgcttta aactattaaa attcttaaga aataaggcta ctttttctgg
     5701 gtcttgttca tagtaggtgt ggttcttttt ttcgagtgta gcccatagct ttgagcgcat
     5761 agtggatggt agttggatga caggcaaatt cagaagctat ttcagtcaaa taagcgtctg
     5821 gattat
//
LOCUS       DBMVGT010000087         5794 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.087, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000087 DBMVGT010000000
VERSION     DBMVGT010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5794)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5794)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5794
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.087"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1797)
                     /locus_tag="AC0DU4_001896"
     CDS             complement(<1..1797)
                     /locus_tag="AC0DU4_001896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014932012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase"
                     /protein_id="HIN4237810.1"
                     /translation="MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQ
                     LMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDH
                     MGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA
                     EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEG
                     IYENIDGMKTSKMKENLINDKEQAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGK
                     FYDEMGFKQLKQALNMSSADVAEGLDFTIVDQISQDMLSEESIFHFELFGENYHTDNL
                     VGFAWSCGDQLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAF
                     DIRLAKYLLSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKL
                     AVLVETEPILLEKLSENGQLELLYDMEQPLAFVLAKMEIAGIVVKKETLLEMQAENEL
                     VIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVDVLERLA
                     PIAPIVKKILDYRQIAKIQSTYVIGLQDWILAD"
     gene            2050..2960
                     /locus_tag="AC0DU4_001897"
                     /pseudo
     CDS             2050..2960
                     /locus_tag="AC0DU4_001897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000603333.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
     gene            3088..3230
                     /locus_tag="AC0DU4_001898"
                     /pseudo
     CDS             3088..3230
                     /locus_tag="AC0DU4_001898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436461.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(3367..4335)
                     /locus_tag="AC0DU4_001899"
     CDS             complement(3367..4335)
                     /locus_tag="AC0DU4_001899"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004749 - ribose phosphate diphosphokinase
                     activity [Evidence IEA];
                     GO_process: GO:0009156 - ribonucleoside monophosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HIN4237811.1"
                     /translation="MSFSDLKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQV
                     NIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRK
                     ARAREPITSKLVANMLEVAGVDRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERR
                     GMVGSDYVVVSPDHGGVTRARKLAEFLKTSIAIIDKRRSVDKMNTSEVMNIIGKVEGK
                     TCILIDDMIDTAGTICHAADALAEAGAVEVYASCTHPVLSGPATDNIQKSAIKKLVVL
                     DTIYLPEERLIDKIEQISIAHLLGDAIVRIHEKRPLSPLFDIEKKI"
     gene            complement(4480..5294)
                     /locus_tag="AC0DU4_001900"
                     /pseudo
     CDS             complement(4480..5294)
                     /locus_tag="AC0DU4_001900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749763.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family intramembrane metalloprotease"
     gene            complement(5319..>5794)
                     /locus_tag="AC0DU4_001901"
     CDS             complement(5319..>5794)
                     /locus_tag="AC0DU4_001901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004089 - carbonate dehydratase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="beta-class carbonic anhydrase"
                     /protein_id="HIN4237812.1"
                     /translation="QANQAYVALHGQLNLPLKPKTRVAIVTCMDSRLHVAQALGLALG
                     DAHILRNAGGRVTEDMIRSLVISQQQMGTREIVVLHHTDCGAQTFENEPFQEYLKEEL
                     GVDVSDQDFLPFQDIEESVREDMQLLIESPLIPDDVIISGAIYNVDTGSMTVVEL"
BASE COUNT         1881 a         1331 c         1026 g         1556 t
ORIGIN      
        1 atcagccaaa atccagtcct gcaagccaat tacataagta gattgaatct tagcaatttg
       61 acggtaatcc aggattttct taacaatcgg agcaatagga gcgagacgct ccaacacatc
      121 cactgctgtc gaataacctg tcttggtttt cttagtgtat tctagaggaa gtcccaattt
      181 ctcaaagaga agcacgccca actgcttagg cgagttgaca ttaaactcct caccagccag
      241 ctcgtaaatc tcttgagtca gtttttcaat gacaagctca ttttcagcct gcatctcaag
      301 caaggtctct ttcttgacca caatcccagc aatttccatc ttggcaagga caaaagccag
      361 aggttgctcc atatcataaa gaagctctaa ttgcccattt tcgctaagtt tttcaagtaa
      421 aataggctct gtttctacca aaacagcaag tttacaagct aagtgttcca agaatttctc
      481 acgttcagga atggcctttt taacaccctt accgtagaaa gtttcatcat caaccaagta
      541 agtctgacca taaagactag cgatggtcgc aatttcattg tcctccacag tcgaaaggag
      601 gtatttagcc aaacggatgt caaaagcagg cgcctgcaaa tctacaccaa aacgttgcaa
      661 aagaacttta accttcttaa agtcataaac tctcagagat gttttttcta agaaatcctt
      721 gaaaatcggg tcttgcaaca gctcaagctt gtctgtggca tagagctgat ccccacaaga
      781 ccaggcaaat ccaaccaaat tatctgtatg gtaattctca ccaaaaagct caaagtggaa
      841 gatagactct tcactcagca tatcttgact gatttggtca acaatagtaa aatccaaacc
      901 ctcagccaca tcagctgacg acatatttaa agcctgcttg agctgtttga agcccatctc
      961 atcgtagaat ttcccaagat tttcaacatc tggaccacta tagaccaagt cctctaaacc
     1021 aatcgcaatc ggtgccttgg tatcaatggt cgctagtgtt ttagacaaaa aggcctgttc
     1081 cttgtcattg atgagatttt ccttcatctt agaagtcttc attccatcaa tattttcata
     1141 aatcccctca agcgaaccat gctccagcaa gagcttaata cccgtctttt caccgacttt
     1201 ggtcacccca gggatattat ccgacttatc acccatgagc gccttgagat cgataaactg
     1261 agctggtgtg aggcccattt cttccatgag gtaatctggc gtaaaggcct caaactcagc
     1321 cacacctttc ttggaaattt caaccaccgt atgctcatcc gtcagctgaa tcaaatcctt
     1381 gtccccactg acaatggtaa tatcaaaacc atcctgctct gctagcttat ccagcgtccc
     1441 aatgatgtca tccgcctcat actgagccag ctcatagtga cgaatcccca tatgatccag
     1501 caactcacga atgaaaggaa attgctcacg aaactcatca ggagtcttgg cccgaccacc
     1561 cttatagtcc gcatacatct ctgtccggaa ggtcgtcttt cccgcatcaa aagccaccaa
     1621 aatatgactc ggctcaaccc gctccaacaa atgactcaac atcaactgaa aaccataaat
     1681 cgcattggta tgcaaaccag ccgcattctt aaaacggtcc aactgctgat acagcgcaaa
     1741 aaacgcccga aaagctacag aagacccatc aatcaataat aattttttct tatccataca
     1801 cccattataa aggaaagaat caaaaaatac cattgggaag agctagagca agtatttttc
     1861 aaactttttc cgaataaata gatagagcca gagaatttag taaacctaga tttaaaaatg
     1921 tgctataata tagtatattg aatctataat agtacacctt gactgctaaa atatttctat
     1981 aaattaattt gactttcctg atagagttgt tcacatctta tttcaattca ctatagaagg
     2041 aggaaaagga tgattctcag acatctggga attagcccga ccaatgactt ggttgctaag
     2101 aaaattttca gcaacccaga aatcacttgt caatttatcc gcgatatgct ggacttgcca
     2161 gccaaaaatg tgactatttt ggagggaagt aacattcatg tcttgccttc catgccctac
     2221 tcagcgcagg atttttatac cagtatagac gtcttggcgg agttggataa cggtactcaa
     2281 gtaattattg agattcaagt ccatcatcag aattttttca tcaatcactt gtgggcttac
     2341 ctgtgcagtc aggttaatca aaatcttgaa aaaattcgtc agcgagaagg tgatactcac
     2401 tagatctaca aacacatcgc tcctgtttac gtcattgcta tcgtggatag taattatttc
     2461 tcagatgacc tggcttttca tagctttagt atgcgcgaag acacaacagg tgaggtattg
     2521 gcgattacca acaatggaca ggaaaaccat ctggttaaga tggcattctt ggaattaaaa
     2581 aatacagaga aaccagcaaa gacaaggttc gcaagccatg gttggagttt ttcggcaaca
     2641 agccctttac ccagcaaccg caacgagcca ttagccaagc aaatcaactg ctggactaca
     2701 agagctggtc cgaggaggac aggaaaatgt ttagtcaact acatatgcga gaagaacaag
     2761 tcttgttagc acaggactat gccttggaaa ctgctagggc tgaaggcctt gaacaaggac
     2821 tagagcgtgg gaaagttgaa ggaagggcag aaaggaaact ttttgccttc ctagacatag
     2881 tacgccaagg tcttctgact tctgaggttg ccagccagca attaggtatg tcagtatctg
     2941 aatttgaggc actgttgtaa aatggctcca taatatccat agtgggtaaa tcccctatgg
     3001 atattatgga gcctattttg tgtaaaaaaa aaagtcccat atgacctata atgaaaagcg
     3061 acaaaacaac tcattagaaa gaatcatatg gaacaattac attttatcac aaaattacta
     3121 gacattaaag accctaatgt ccagatttta aacatcatca ataaggatac acacaaggaa
     3181 agcgtcgatt caaatgctat cactgttcaa aaatgatggt cgctgaaact tatgatgacg
     3241 tacagtcata tttcttttct ttttattata tcacagtttt aaatctagct ttactagatt
     3301 caccgctact atctatttat tcggaaaaaa gacgaaaaaa cctgagaatc atctcaggct
     3361 tggtcattaa atttttttct caatatcgaa aagtggagaa agtggtcgtt tttcatgaat
     3421 acgtacgata gcatccccta ggagatgagc gattgaaatc tgctcaatct tatcaatcaa
     3481 acgctcttct ggcagataga tggtatccaa aacaaccaat ttcttaatag ctgatttttg
     3541 gatattgtcc gtagcaggac cagaaagaac tgggtgcgta cagcttgcat agacttcaac
     3601 agcaccagct tccgcaagag catctgccgc atgacaaatc gttccagcgg tatcaatcat
     3661 atcatcaatc aagatacaag tcttgccttc aaccttaccg atgatgttca taacttcact
     3721 agtattcatc ttatcaacgc tacgacgttt atcaataata gcgatagatg ttttcaaaaa
     3781 ttctgccaac ttacgagcac gagtcacccc tccatggtcc gggctgacaa ccacatagtc
     3841 agaaccaacc ataccacgac gctcaaaata atctgcaatc agaggagcac ccatcaaatg
     3901 atccacagga atatcaaaga atccttgaat ttgcgcagca tgcaagtcga tggtcaataa
     3961 acgatccact ccagctactt caagcatatt tgcgacaagt tttgaagtga ttggctcacg
     4021 cgctctcgcc tttctatcct gacgtgcata cccatagtaa ggcatgacaa cattgacaga
     4081 ttctgcactc gcacgcttca aagcatctac cataatcaaa atttcaagca gattgtcatt
     4141 tacaggcgaa ctagttgatt gtaagataaa gacgtgtttc ccacggattg attcttcaat
     4201 gttgacctga atctctccat ctgaaaattg gcgaacactt gatttcccca actctatccc
     4261 aatctcctgc gccacacgtt ctgccaattc tttattagaa gaaagggcaa acagctttaa
     4321 atcagaaaaa gacatgattt cctccggtat atatgtatag cttgtgcttt tcacaagatt
     4381 ttccatctac cattgtagcg ctttttgcac tatttttcaa tcaaaaataa aagaagggca
     4441 ccatatttgt acccttgcat cattcttttg aaaaatattc taggtcatca actcattgtg
     4501 tttctcaaca aagcaataag catgataaaa accatagaga gcaatagccg taaccactgg
     4561 aatcgctaaa ggcaactctg tttccaactc cacaaaagga gagttaaaca agaagtgagt
     4621 tcccaaggct aaacctagaa aaataaggcc ctgtttcttg ccaaccttct gtcctttata
     4681 ggctctgtaa agcaagtaaa cacctactac agctagacct gaaaaagtcc agtgagaggc
     4741 aattcctgag atgatacgct ctaaaattcg cgaaatagta aagtcaaagc cctctggcaa
     4801 atccgtacga atataaccaa tatcctcaat catttggaat cccaaaccgg aagcaattcc
     4861 aagtaaaaac aaagatttta attttcgcac aggaatcaaa gccaaaacaa aaacaagtgg
     4921 caataatttc aagggttctt ctaccaaagg agccacaata gcactttcaa aggcatttaa
     4981 aaatggacta tctgggaaaa gaacccccag taaatcatgg atataagtat tagcaaaact
     5041 agacaaccag cctgaaagga acatccctcc caataaagac agaatcaaaa ccttctttgg
     5101 caattcccat ttttcccaat acggaagaga aaataaagag ccggaatcat gtaaaagaga
     5161 gctagaaaga tagaaactcc cattagtcca tattccgcac ctgacctcga accgtccgta
     5221 tagtagatgg tttcatactg taaaccaata catagcaata aaataaaaat aaataaaata
     5281 ctgcttttct tcatacactt tctttctaaa tgaagtattt ataattctac gactgtcata
     5341 cttcctgtat caacattgta aatggcacca gagataatga catcgtctgg tattagggga
     5401 gactcgataa gcagttgcat atcctcgcgt acactctctt ctatatcttg gaagggcaag
     5461 aagtcctggt ctgacacatc tacacctaat tcctctttta aatactcctg aaaaggttca
     5521 ttttcaaagg tctgagcacc acagtctgta tggtgcaata ccacaatctc tcttgtcccc
     5581 atttgttgct gggaaataac tagcgaacga atcatgtctt cagtcactcg accacctgca
     5641 ttccgcaaga tatgagcatc cccaagtgcc aagcccagag cttgcgcaac gtgcagacga
     5701 gagtccatac aggtcacaat agctactctt gttttgggtt taagtggcag atttaactgc
     5761 ccatgtaggg caacataagc ctgattggct tgca
//
LOCUS       DBMVGT010000088         5724 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.088, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000088 DBMVGT010000000
VERSION     DBMVGT010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5724)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5724)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5724
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.088"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            953..2212
                     /locus_tag="AC0DU4_001902"
     CDS             953..2212
                     /locus_tag="AC0DU4_001902"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008760 - UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase activity [Evidence IEA];
                     GO_process: GO:0019277 - UDP-N-acetylgalactosamine
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HIN4237813.1"
                     /translation="MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCV
                     PDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLL
                     GRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGVSIYM
                     DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIID
                     GVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMT
                     VSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVN
                     HVFELAKMDADISTTNGHILYTGGRYLRGTSVKATDLRAGAALVIAGLMAEGKTEITN
                     IEFILRGYSDIIEKLRNLGADIRLVED"
     gene            2228..2779
                     /locus_tag="AC0DU4_001903"
     CDS             2228..2779
                     /locus_tag="AC0DU4_001903"
                     /EC_number="2.3.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4237814.1"
                     /translation="MNIWTKLAMFSFFETDRLYLRPFFFSDSQDFREIASNPENLQFI
                     FPTQASLEESQYALANYFMKSPLGVWAICDQKNQQMIGSIKFEKLDEIKKEAELGYFL
                     RKDAWSQGFMTEVVRKICQLSFEEFGLKQLSIITHLENEASQRVALKSGFSLFRQFKG
                     SDRYTRKMRDYLEFRYVKGEFNE"
     gene            2772..4049
                     /gene="spxR"
                     /locus_tag="AC0DU4_001904"
     CDS             2772..4049
                     /gene="spxR"
                     /locus_tag="AC0DU4_001904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS-HotDog domain-containing transcription
                     factor SpxR"
                     /protein_id="HIN4237815.1"
                     /translation="MSKHQEILSYLEELPVGKRVSVRSISNHLGVSDGTAYRAIKEAE
                     NRGIVETRPRSGTIRVKSQKVAIERLTFAEIAEVTSSEVLAGQEGLEREFSKFSIGAM
                     TEQNILSYLHDGGLLIVGDRTRIQSLALENENAVLVTGGFQVHDDVLKLANQKGIPVL
                     RSKHDTFTVATMINKALSNVQIKTDILTVEKLYRPSHEYGFLRETDTVKDYLDLVRKN
                     RSSRFPVINQHQVVVGVVTMRDAGDKSPSTTIDKVMSRSLFLVGLSTNIANVSQRMIA
                     EDFEMVPVVRSNQTLLGVVTRRDVMEKMSRSQVSALPTFSEQIGQKLSYHHDEVVITV
                     EPFMLEKNGVLANGVLAEILTHMTQDLVVNSGRNLIIEQMLIYFLQAVQIDDILRIQA
                     RIIHHTRRSAIIDYDIYHGHQIVSKANVTVKIN"
     gene            4065..4925
                     /locus_tag="AC0DU4_001905"
     CDS             4065..4925
                     /locus_tag="AC0DU4_001905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HIN4237816.1"
                     /translation="MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYV
                     RRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLG
                     GPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEA
                     MYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAG
                     RGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVI
                     LTSQGEEGTY"
     gene            5305..5724
                     /locus_tag="AC0DU4_001906"
                     /pseudo
     CDS             5305..5724
                     /locus_tag="AC0DU4_001906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
BASE COUNT         1749 a          930 c         1293 g         1752 t
ORIGIN      
        1 actatattgt tataaattga tttgaatttc aaaattaaat tgtttgattc ttatttcaat
       61 ttgttatagt atatctgatg tcaaagttct cggcgagtca aatagcgatt cccaagcctg
      121 actatcgtga ggtagcggat taaaatggtc tggggataga ccgttttaag tctgacgctg
      181 gaaataagaa ttgtcagaag aagggatagc gaactcgtgg ctctacgaac aggaacgtga
      241 taataaggcg tatatagcgg ataagagggc ctcaaactct aaagtccaaa aaggtattcg
      301 taacctatat gcgtaaatta cgagagtaat tgaattcgta ctaagatttt ctattttcac
      361 tgtaagcttt taacgccctt atatcttgta tacacgagga aagatgtacg acttatcccg
      421 tgaggtctat cactataaag agaaaacgac agatagaagt gatcctgagt cacggttatc
      481 tttaaaatag attgtctgat aggacggtat gtataaaacg cttctgtgaa ctgagagaag
      541 ggggagaagt tcttgctaaa atttagttga acagccgtat tccgatactt agataagaga
      601 tctagtctta gctcctactc agttttaggg gataaaaaag gggcaatagc gattcgagaa
      661 agattatact cttcgaaaat ctcttcaaat cacgtcaata tcgccttgcc gtatgtgtag
      721 gatactgact acgtcagttc catctacaat ctcaaaacag tgttttgagc aacctgcggc
      781 tagtttccta gtttgatctt tgatttttat tgagtattag taattcagtt actaactcgt
      841 caactctgat ttatccaata aaattgaaaa ggatggaaaa aaggataaat ttatgatata
      901 ctttattttg aagaccttat tagaaatctt gaaagagtat tgaaaactta gaatgagaaa
      961 aattgttatc aatggtggat taccactgca aggtgaaatt actattagtg gtgctaaaaa
     1021 tagtgttgtg gccttaattc cagctattat attggctgat gatgtggtga ctttggattg
     1081 tgttccagat atttcggatg tagccagtct tgtcgaaatc atggaattga tgggagctac
     1141 tgttaagcgt tatgacgatg tcttggagat tgatccaaga ggtgttcaaa atattccaat
     1201 gccttatggt aaaattaaca gtcttcgtgc atcttactat ttttatggga gcctcttagg
     1261 ccgttttggt gaagcgacag ttggtctacc gggaggatgt gatcttggtc ctcgtccgat
     1321 tgacttacac cttaaggcgt ttgaagctat gggtgccact gctagctacg agggagataa
     1381 catgaagtta tctgctaaag atacaggact tcatggtgta agtatttaca tggatacggt
     1441 tagtgtggga gcaacgatta atacgatgat tgctgcggtt aaagcaaatg gtcgtactat
     1501 tattgaaaat gcagcccgtg aacctgagat tattgatgta gctactctct tgaataatat
     1561 gggtgcccat atccgtgggg caggaactaa tatcatcatt attgatggtg ttgaaagatt
     1621 acatgggaca cgtcatcagg tgattccaga ccgcattgaa gctggaacat atatatcttt
     1681 agctgctgca gttggtaaag gaattcgtat aaataatgtt ctttacgaac acctggaagg
     1741 gtttattgct aagttggaag aaatgggagt gagaatgact gtatctgaag acagcatttt
     1801 tgtcgaggaa cagtctaatt tgaaagcaat caatattaag acagctcctt acccaggctt
     1861 tgcaactgat ttgcaacaac cgcttacccc tcttttacta agagcgaatg gtcgtggtac
     1921 aattgtcgat acgatttacg aaaaacgtgt aaatcatgtt tttgaactag caaagatgga
     1981 tgcggatatt tcgacaacaa atggtcatat tttgtacacg ggtggacgtt atttacgtgg
     2041 gaccagtgtt aaagcgaccg acttaagagc tggggctgca ctagtcattg ctgggcttat
     2101 ggctgaaggt aaaactgaaa ttaccaatat cgagtttatc ttacgtggtt attctgatat
     2161 tatcgaaaaa ttacgtaatt taggagcgga tattagactt gttgaggatt aaaccgtaga
     2221 ggtgtttatg aatatttgga ccaaattagc aatgttttct ttttttgaaa cggatcgctt
     2281 gtatttgcgt cctttctttt ttagtgatag tcaggacttc cgcgagatag cttcaaatcc
     2341 agaaaatctt caatttattt tcccaacgca ggcaagtctg gaagaaagtc aatatgcact
     2401 ggccaattac tttatgaagt cccctttggg agtgtgggca atttgtgacc agaaaaatca
     2461 acaaatgatt ggttctatta aatttgagaa gttagatgaa atcaaaaaag aagctgagct
     2521 tggctatttt ttgagaaaag atgcttggtc gcaaggattt atgacagagg ttgttagaaa
     2581 aatttgtcag ctttcttttg aggaatttgg cttaaaacaa ttatctatca ttacccacct
     2641 tgaaaatgaa gctagccaaa gagttgctct taagtctgga tttagtttgt tccgtcagtt
     2701 taagggaagt gatcgttaca caagaaaaat gcgggattat cttgaatttc ggtatgtaaa
     2761 aggagagttc aatgagtaag catcaggaaa ttctaagcta tttggaggaa ttaccagtag
     2821 gtaaaagggt cagtgttcgt agcatttcga atcatctagg agttagtgat ggaacagcct
     2881 atcgggctat taaagaagct gaaaaccgtg gaattgtgga gacccgtcct agaagtggaa
     2941 caattcgtgt taaatcccag aaagttgcta tagagagatt aacgtttgct gaaattgcag
     3001 aagtgacttc ttctgaggtt ctggctgggc aagaaggttt agagagagaa tttagtaagt
     3061 tttcaattgg tgccatgact gaacaaaata tcttgtctta ccttcatgat ggggggctct
     3121 tgattgtcgg agaccgaacc cgtattcagt cgctagcctt ggaaaatgaa aatgcagttc
     3181 tggttacagg gggatttcag gttcatgatg atgtgcttaa actggccaat caaaaaggga
     3241 tccctgttct aagaagtaag catgatacct ttaccgtcgc gaccatgatc aataaagcct
     3301 tgtcaaatgt ccaaatcaag actgatattc tgacagttga gaaactttat cgccctagtc
     3361 atgagtatgg ttttctgaga gagacagata cagttaaaga ttatttggac ttggttcgta
     3421 agaatcgtag cagccgtttc cctgttatca atcaacatca ggtcgttgtt ggcgttgtaa
     3481 ccatgagaga cgctggtgat aaatcaccaa gcacgacaat tgataaggtt atgtctcgta
     3541 gtctattttt ggttggatta tcgacaaata ttgccaatgt gagtcaacgg atgatcgcag
     3601 aagactttga aatggtacca gttgttcgaa gcaatcaaac tttgcttggc gttgtgacgc
     3661 gacgagatgt catggagaag atgagccgtt cccaagtttc ggctctacca actttttctg
     3721 agcagattgg acaaaagctc tcttatcacc atgatgaagt agtcattaca gtggaaccct
     3781 ttatgctaga aaaaaatgga gttttggcta atggtgtatt ggcagaaatt ctgacccaca
     3841 tgacccaaga tttagttgtt aatagtggtc gcaatctcat tatcgagcag atgctgatct
     3901 actttttgca ggctgttcag atagatgata tattgcgcat tcaggcacgg attattcatc
     3961 atacgagacg gtcagctata attgattacg atatttatca tggtcaccag attgtttcaa
     4021 aagcaaatgt gactgttaaa attaattaga aactaggaga aaagatgata acattaaaat
     4081 cagctcgtga aatcgaagct atggacaagg ctggtgattt tctagcaagt attcatatag
     4141 gcttacgtga tttgattaag ccaggcgtag atatgtggga agttgaagaa tatgtccgcc
     4201 gtcgttgtaa agaagaaaat ttccttccac ttcagattgg ggttgacggt gccatgatgg
     4261 actatcctta tgctacctgt tgctctctta acgatgaagt ggctcacgct ttccctcgtc
     4321 attatatctt gaaagatggt gatttgctca aagttgatat ggttttggga ggtcccattg
     4381 ctaaatccga cctgaatgtc tcaaaattaa acttcaacaa tgttgaacaa atgaaaaaat
     4441 acactcagag ctattctggt ggtttagcag actcatgttg ggcttatgct gttggtacac
     4501 cgtccgaaga agtcaaaaac ttgatggatg taaccaaaga agctatgtac aagggtattg
     4561 agcaagctgt tgttggaaat cgtatcggtg atatcggtgc ggctattcaa gaatacgctg
     4621 aaagtcgtgg ttacggtgta gtgcgtgatt tggttggtca tggtgttggc ccaactatgc
     4681 acgaagaacc aatggttcct aactatggta ttgcaggtcg tggactccgt cttcgtgaag
     4741 gaatggtctt aaccattgaa ccaatgatca atacaggcga ttgggaaatt gatacagata
     4801 tgaaaactgg ttgggcgcat aagaccattg acggtggatt gtcatgtcag tatgaacacc
     4861 aatttgtcat tacgaaagat ggacctgtta tcttgactag ccaaggtgaa gaaggaactt
     4921 attaataaaa agtgaaaaga ctactggaag tttattttga taaaaaatcc agtagatctt
     4981 ttcataataa aacgcattgt atcaagtgtt aggggctgat atcatgcgtt tttctgcttt
     5041 taagattttt tccaactctg tttgtaagcg catcataaca aagggtctag gattcagggc
     5101 tctcctccta tatactatta gtaaagtaaa actaagggag gatattttag tgtcgcagtc
     5161 tattgttcct gtagagattc cacaatattg tcgttttgat tctaaaaaga gaaatggaat
     5221 tctgtttaac gtttgtattg ccaatcttaa atttattttt ttatattata cttcctgcga
     5281 aacaaaatat ggtatagtag ttctatgaat gatgaagcaa gtaaacaact aactgatgca
     5341 cgatttaagc gtcttgttgg tgttcagcgt accacttttg aagagatgtt agctgtatta
     5401 aaaacagctt atcaacttaa acacgcaaaa ggtggacgaa aacctaaatt aagcctagaa
     5461 gaccttctta tggccactct tcaatagtgc gagaatatcg aacttatgaa caaattgcgg
     5521 ctgattttgg tattcacgaa agcaacttac tccgtcggag ccaatgggtt gaagtaactc
     5581 ttgttcaaag tggttttacg atttcaagaa ctcctctcag ttctgaggac acggtaatga
     5641 ttgatgcgac ggaagtaaaa atcaatcgcc ctaaaaaaac aattagcgaa tgattctggt
     5701 aaaaagaaat gccacgctat gaag
//
LOCUS       DBMVGT010000089         5695 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.089, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000089 DBMVGT010000000
VERSION     DBMVGT010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5695)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5695)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5695
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.089"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            461..649
                     /locus_tag="AC0DU4_001907"
     CDS             461..649
                     /locus_tag="AC0DU4_001907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237817.1"
                     /translation="MSVDIEAIRWLLDNATAYAISKNCGMSIQAVDKYKNGVSDIMNM
                     RLKHAISMITYAQELKKQ"
     gene            complement(870..1826)
                     /locus_tag="AC0DU4_001908"
     CDS             complement(870..1826)
                     /locus_tag="AC0DU4_001908"
                     /EC_number="3.5.1.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000350478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA];
                     GO_process: GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="HIN4237818.1"
                     /translation="MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTVQNEADYHYR
                     KDPELGFFSHVVGNGRVMQVGPVNNGSWDVGGGWNTESYAAVELIESHSTKEEFMTDY
                     RLYIELLRNLADEAGLPKTLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLASWGIS
                     REQFKQDIENGLSAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSD
                     RWKKHTDGNWYYFDQSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEG
                     AMVSNAFVQSADGTGWYYLKPDGTLADKPDFTVEPDGLITVK"
     gene            complement(1830..2162)
                     /locus_tag="AC0DU4_001909"
     CDS             complement(1830..2162)
                     /locus_tag="AC0DU4_001909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001186229.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0140911 - pore-forming activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin"
                     /protein_id="HIN4237819.1"
                     /translation="MQQITEIITNGAISILVILAGIAVKAVKEYLVKKGGEKTIKIVE
                     ILAKNAVNAVEQVAAETGYKGDEKLAQARAKVRAELTKYNISMTDKDLDTFVESAVKQ
                     MNDAWKGR"
     gene            complement(2166..2582)
                     /locus_tag="AC0DU4_001910"
     CDS             complement(2166..2582)
                     /locus_tag="AC0DU4_001910"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003038967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phage holin family protein"
                     /protein_id="HIN4237820.1"
                     /translation="MQIEFFNFLRSVVQTEDGLVLYALALIVSMEIIDFVTGTIAAII
                     NPDIEYKSKIGINGLLRKISGVLLLMILIPASVLLPEKTGFVFLHSIYLGYIAFTFQS
                     LIENYRKLKGNVTLFQPIVKVFQRLLEKDDDTKKGE"
     gene            complement(2591..2941)
                     /locus_tag="AC0DU4_001911"
     CDS             complement(2591..2941)
                     /locus_tag="AC0DU4_001911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237821.1"
                     /translation="MAETIQNTDNLLDLTKITEPFDLASALRYMKENGEFIRCKNVSD
                     DFYMYRDVQKRPVIVNGRRQFKDIETVWAFNQWGGTITTINVAVLLNHEFYIMKFDAE
                     GNPDWTNPTVEPKE"
     gene            complement(2944..3147)
                     /locus_tag="AC0DU4_001912"
     CDS             complement(2944..3147)
                     /locus_tag="AC0DU4_001912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001091107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237822.1"
                     /translation="MNTEQLNQALQMTIREMSTTSTNSMITSNILSIQLNEQREENQR
                     LQARVDELEALLDEQTKPADKGE"
     gene            complement(3128..3244)
                     /locus_tag="AC0DU4_001913"
     CDS             complement(3128..3244)
                     /locus_tag="AC0DU4_001913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001063632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate reductase"
                     /protein_id="HIN4237823.1"
                     /translation="MNNNMLTNIALKAIQEFALENRKRTHRLENLENEHRTA"
     gene            complement(3241..>5695)
                     /locus_tag="AC0DU4_001914"
     CDS             complement(3241..>5695)
                     /locus_tag="AC0DU4_001914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000966215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="tail fiber domain-containing protein"
                     /protein_id="HIN4237824.1"
                     /translation="LRFNLEGATSGTAWVTGIKVEIGSVATDWSPAPEDADGLITEAK
                     ATFERTAQGLRTDLSAIQEYVNKDGQRQEALQRYTREESTRQATAVRELVNRDFVGKA
                     TYQEDVKGINQRIEAVKTSANKDIASQIASYRQSVDGKFTDISSQITTYKQDVGGQIS
                     GLSNRLTSSEQGTTTQISNLSNRINSNKQGTDNQISNLKTQVATNKDNAERQMGRISD
                     QVSANKANADSQFANVTNQLARKVETTDFQRVKETSKLYERILGNTENGIADKVARMA
                     LTNQLFQVEVAKNASNGQNLLKGTKDFSGGWKNKGANWKKHAEKYKGVDVLFKNNSWN
                     GVGQEIDAKIGEVYTFSLWMKSDWKNDTVNFYVNRNGSVEKGWGVPSETSVAITSEWK
                     RYSFAFKITVDGFIFPRVERLNQNTNLYIAGLKLEKGSYATPYTEAPEDTDEAIRSVQ
                     SQLTGSWAVQNINSAGDIISGINLGANGHNRFVGKLTHITGETLIDRAVIKSAMVDKL
                     KTANFEAGSVTTTILDAEAVTADKVRFDAAFIRKMTANDAFIDQLTSKRIFSTKVESV
                     ISSSTFLEAYQGRIGGFTIGRFAQGRGRWISGINQFSVGMGNGEGGSYNGENTAFWAN
                     WGHSWNSPGPNAWYVTTSGNMYCRNGADFHGKVDFSNSSRANFYGNTTFSRSPVFSNG
                     IELGSKDVLGDGWNPKGGRNAVVWWNQVGSGSVKYWMEQKSDRRLKENITDTAVKALD
                     KINRLRMVAFDFIENKKHEEIGLIAQEAETIVPRIVSRDPENPDGYLHIDYTALVPYL
                     IKAIQELNQKIEKMEKTIA"
BASE COUNT         1514 a         1285 c         1063 g         1833 t
ORIGIN      
        1 taaaataaaa tcttattaaa tcaacactct tggagggtgt cccctccaac tccccgacct
       61 ctggacaagg tctatttttt tgaaaaaaat ttatcaaaac cattgacttt ctacaactaa
      121 agttgtataa tagatacata aggttaagga ggaaacctta gacaaggaaa ctagtagaaa
      181 ggaacatgaa atgtttaagt tcaaaaagaa accactcaaa gtcaaaacaa ataagctagt
      241 catcaaaata aacttattta taatcagctt tgaatggcac ttagaaattg gatagtgaga
      301 aatcactatc caccccttag gggggtgtac ttaaattata acaggaaaaa caatgaaagt
      361 aaatcttaaa attagaaaaa ccaccaagcg tgaaaaagtt gaattcatta ttggatttgt
      421 tctacttcta tttgcgattt ggtattttac gaggtaatat atgtcagtag atattgaagc
      481 tatccgctgg cttttagaca atgccacagc ctatgctatt agcaaaaact gtggcatgtc
      541 tattcaggcc gtggacaagt ataaaaatgg tgtgtcagat attatgaata tgcgtctaaa
      601 acacgctatc agcatgataa catacgccca ggaacttaaa aagcagtgat ttcggtcact
      661 gtttttattt ttaacaaaac accgtttttg acaataatca aaaaataaaa aggagctatt
      721 attaacaaaa tggcgttttt ggcaataata ccctgccatt cctcctccct attcttcatg
      781 taaacgcttt tttgaagaat cagagcaaac aaaaaaaccg caagcctgag cctgcggtga
      841 aagaacaatt tagaaagttt cctttctatt tatttaactg taatcaagcc atctggctct
      901 actgtgaagt ctggcttatc tgccagtgtt ccgtctggtt tgaggtagta ccagcctgtt
      961 ccgtctgcgg actggacgaa ggcgtttgat accatagcgc cttctttagc gtctaagtag
     1021 taccaagtgt ccttgtactt gacccagcct gtcttcatgg caccttcttc gttgaaatag
     1081 taccacttgt cagcgatttt cttccagcct gtggccattt cgcctgattg gtcaaagtag
     1141 taccaattac cgtctgtgtg cttcttccag cggtctgaaa gcatatagcc tgagccatcg
     1201 aaataatacc aggtaccgtt gattttctca aacttatctt ttggataaga accgtctgag
     1261 tgtacgtacc agtagccagt gccatttttc tgccagcctg ttgcagcgct caagccgttt
     1321 tcgatgtctt gcttaaattg ttcacggcta atgccccaac ttgcaagata tggatatgga
     1381 tccacatggt ctgagtggtt gtttggttgg ttattggtac agtattcatg cgtcttgata
     1441 cctgccaagt cgtctgtatc aagagtcttc ggcaagcctg cttcgtccgc tagattgcgt
     1501 agcaattcga tatagaggcg gtagtccgtc atgaactctt ctttagttga atggctttca
     1561 atcagttcaa ccgctgcgta actctcagta ttccaaccgc ccccaacatc ccaacttccg
     1621 ttgttcacag gacctacttg catgacacgg ccgtttccga caacatgtga aaagaaccct
     1681 agttcagggt cctttctata gtgataatcc gcttcattct gtacggttga gttgcggtta
     1741 cctgttgagt gagcatgtac ttgtcgataa ggctgcaccc caacctgtgg caagcctgta
     1801 cgtagtctgt ttctatcgat atccattccc tatcgtcctt tccatgcgtc attcatctgc
     1861 ttcactgctg actctacgaa ggtgtctaag tctttgtcag tcatgctaat attgtatttt
     1921 gtaagctcag cacggacttt agcgcgagcc tgtgccagtt tttcatctcc cttgtagcca
     1981 gtttcagcag ctacctgctc cacggcatta actgcgttct tggccaagat ttcaacaatc
     2041 ttgatagtct tttctccacc ttttttgacg aggtattcct tgactgcctt gactgcgata
     2101 ccagccaaaa taacaaggat gctgattgct ccattagtaa tgatttcagt aatttgttgc
     2161 atttgttatt ctcctttttt cgtatcatca tctttttcaa gtaatcgctg aaatactttt
     2221 acaatcggct gaaaaagagt aacatttcct tttaatttgc ggtaattttc aatgagagat
     2281 tgaaaagtaa atgcgatgta cccgagatag attgagtgca agaatacaaa acctgtcttt
     2341 tcaggcaaca aaacggacgc cggaatgagg atcatcagta agagaacccc tgaaatctta
     2401 cgaaggagcc cgttaatgcc gattttgctc ttgtactcga tgtcaggatt gataatcgcc
     2461 gcaatcgtcc ctgtcacaaa atcaatgatt tccattgaga caatcagtgc tagagcgtac
     2521 aataccaaac catcttcagt ctgtacgaca cttcttagaa aattgaaaaa ttcaatttgc
     2581 atacaacctc ctattcttta ggttctaccg ttggattcgt ccagtcagga ttgccctctg
     2641 catcaaattt catgatatag aattcatgat tcaacagaac ggctacgttg attgttgtta
     2701 ttgtaccacc ccactggttg aacgcccaaa cggtttcaat atccttgaat tggcgacggc
     2761 catttacgat cacaggacgt ttttgaacgt cacgatacat atagaagtca tcgcttacat
     2821 tcttgcaacg aatgaactct ccattttctt tcatgtagcg caaagcactc gcaagatcaa
     2881 atggttctgt gatttttgta aggtctagta agttatctgt gttttgaatt gtttctgcca
     2941 tgtctattct cctttgtctg ctggtttagt ttgttcatca agcagagctt ccagctcatc
     3001 cactcgtgct tgaagtcttt gattctcttc cctttgctca tttaactgaa tactcaagat
     3061 attacttgta atcatcgaat ttgttgaagt tgttgacatt tcacgaattg tcatttgtaa
     3121 ggcttggtta agctgttctg tgttcatttt ctaagttctc caatctgtgt gttcgttttc
     3181 tattttcaag agcaaactcc tgaattgctt taagtgcgat attggtcaac atgttgttat
     3241 tcatgctatt gttttctcca ttttttctat tttttgattt aattcttgaa tagccttgat
     3301 taagtaagga actaaagcgg tatagtcaat atgcagatag ccatctggat tctcaggatc
     3361 tcgtgagaca attcttggaa cgatggtttc agcctcttga gctattagac caatctcctc
     3421 atgtttctta ttttcgatga aatcaaatgc aaccattctt aatctgttga ttttatccaa
     3481 ggctttcaca gctgtatctg tgatgttctc ttttaagcgt ctgtctgatt tttgttccat
     3541 ccaatacttc acgctaccgc taccgacctg attccaccaa acaaccgcat tccttcctcc
     3601 tttgggattc cagccatcac caagcacatc tttacttcca agttcgatac catttgaaaa
     3661 cacaggagaa cgagaaaaag tagtattccc ataaaagttt gctctcgatg aattcgaaaa
     3721 gtcaaccttc ccgtggaaat ctgctccgtt tcggcaatac atatttcctg atgttgttac
     3781 ataccaagca ttggggccag gagagttcca actgtgaccc cagttcgccc aaaatgcggt
     3841 attttcgcca ttatagcttc ctccttcacc attccccatg ccaactgaga attggttgat
     3901 accagaaatc cagcgacctc ttccttgagc aaaacgccca atagtgaatc caccgattcg
     3961 gccttgatag gcttctagga aggttgaact agaaatgacg gactcaacct tagtagagaa
     4021 gatacgttta gatgtcagtt ggtcaataaa agcgtcattt gcagtcattt ttctaataaa
     4081 cgcagcatca aatctcactt tatcagccgt gaccgcttca gcgtctaata tcgtagtcgt
     4141 gaccgaacca gcttcaaaat tggccgtttt gagcttatca accatggcag acttgatgac
     4201 tgctctgtca atcagggtct ctccagtgat gtgggtcaat ttcccaacaa agcggttatg
     4261 tccattggcg ccaagattga ttccagagat gatatctcca gccgagttga tgttttgaac
     4321 tgcccatgag ccagttagtt ggctttgaac agagcgaatc gcttcgtccg tgtcttcagg
     4381 agcttcggtg tacggtgttg catacgatcc tttttcaagt ttaagacctg caatatatag
     4441 atttgtattt tgattaagtc gttctacacg aggaaagatg aagccgtcca cagtaatttt
     4501 gaaggcaaat gagtaacgtt tccattcact tgttatagcg accgatgttt cagatggaac
     4561 accccaacct ttctcaacag atccatttct atttacatag aaatttactg tatcattctt
     4621 ccagtcgctc ttcatccata agctgaatgt atagacttca ccaatttttg catcaatctc
     4681 ttgtccaacg ccattccacg aattattttt aaataggaca tcaacacctt tgtatttttc
     4741 agcgtgcttt ttccaatttg cacccttgtt tttccaaccc cctgagaagt cttttgtgcc
     4801 tttcaacaaa ttttgaccat tgctggcatt tttagccacc tcaacctgaa acagttgatt
     4861 ggtcagagcc atgcgagcaa ccttatccgc aattccattt tcagtattgc ccaaaatccg
     4921 ctcgtaaagt ttactggttt ccttaacacg ctggaagtca gtagtctcta cttttcgcgc
     4981 tagttgattg gtcacattcg caaattgact atcagcattc gctttgtttg cagaaacctg
     5041 atcagatatt ctacccattt gtcgttcagc attatccttg tttgtagcga cctgagtctt
     5101 taaatttgaa atctgattat ctgtgccttg cttattactg tttatccgat ttgaaagatt
     5161 tgaaatctga gtagtggttc cttgctcact gcttgtaagt ctatttgata gaccactgat
     5221 ttgaccgccc acatcttgct tataagtagt tatctgactt gaaatatccg tgaacttacc
     5281 atctacagat tgacgatagc tagcgatttg actagcgatg tctttattcg cactagtttt
     5341 aacagcttca atcctttgat tgataccctt aacatcttct tgataagtag ccttaccaac
     5401 gaaatcacga ttgaccagct cacggactgc tgtcgcttgt ctcgtgctct cctcacgagt
     5461 atagcgctgt agggcttcct gtcgctgacc gtctttattt acatattcct gaatagctga
     5521 taagtcggtt cgcaagccct gagctgtccg ctcaaaggta gccttagctt cagtgatgag
     5581 accatcagcg tcctcaggcg caggactcca gtccgtcgcc acactaccga tttcaacctt
     5641 gattcctgtt acccaagctg tgccgcttgt agcaccttca agattgaatc gcaat
//
LOCUS       DBMVGT010000090         5694 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.090, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000090 DBMVGT010000000
VERSION     DBMVGT010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5694)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5694)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5694
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.090"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..352
                     /locus_tag="AC0DU4_001915"
     CDS             <1..352
                     /locus_tag="AC0DU4_001915"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0010181 - FMN binding [Evidence IEA];
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="HIN4237825.1"
                     /translation="AHSWGWIAEDGEQAVKDYFHPTKQVVDAISKDRPHWQELRYEQY
                     LEQVGPNGAMFVGNPDQVAEKLIRMIEDLGLDRFMLHIPLGSMPHDQVLRAIELFGTQ
                     VAPKVRAYFAMKEA"
     gene            complement(452..4249)
                     /gene="spuA"
                     /locus_tag="AC0DU4_001916"
     CDS             complement(452..4249)
                     /gene="spuA"
                     /locus_tag="AC0DU4_001916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored pullulanase SpuA"
                     /protein_id="HIN4237826.1"
                     /translation="MRKTPSHTEKKMVYSIRSLKNGTGSVLIGASLVLLAMATPTISS
                     DESTPTTNEPNNRNTTTLAQPLTDTAAGSGKNESDISSPRNANASLEKTEEKPATEPT
                     TSTSPVTTETKAEEPIEDNYFRIHVKKLPEENKDAQGLWTWDDVEKPSENWPNGALSF
                     KDAKKDDYGYYLDVKLKGEQAKKISFLINNTAGKNLTGDKSVEKLVPKMNEAWLDQDY
                     KVFSYEPQPAGTVRVNYYRTDGNYDKKSLWYWGDVKNPSSAQWPDGTDFTATGKYGRY
                     IDIPLNEAAREFGFLLLDESKQGDDVKIRKENYKFTDLKNHSQIFLKDDDESIYTNPY
                     YVHDIRMTGAQHVGTSSIESSFSTLVGAKKEDILKHSNITNHLGNKVTITDVAIDEAG
                     KKVTYSGDFSDTKHPYTVSYNSDQFTTKTSWHLKDETYSYDGKLGADLKEEGKQVDLT
                     LWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDSTNKLGITDFTGYYYQY
                     QIERQGKTVLALDPYAKSLAAWNSDDAKIDDAHKVAKAAFVDPAKLGPQDLTYGKIHN
                     FKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDYLKDLGVTHIQLLPVL
                     SYYFVNELKNHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSDPKNPEKRIAEFKNLI
                     NEIHKRGMGAILDVVYNHTAKVDIFEDLEPNYYHFMDADGTPRTSFGGGRLGTTHHMT
                     KRLLVDSIKYLVDTYKVDGFRFDMMGDHDAASIEEAYKAARALNPNLIMLGEGWRTYA
                     GDENMPTKAADQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPAFITGGKRDVNTIFKN
                     LIAQPTNFEADSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKAENYAEIHRRLRLGNL
                     MVLTAQGTPFIHSGQEYGRTKQFRDPAYKTPVAEDKVPNKSHLLRDKDGNPFDYPYFI
                     HDSYDSSDAVNKFDWTKATDGKAYPENVKSRDYMKGLIALRQSTDAFRLKSLQDIKDR
                     VHLITVPGQNGVEKEDVVIGYQITAPNGDIYAVFVNADEKAREFNLGTAFAHLRNAEV
                     LADENQAGSVGIANPKGLEWTEKGLKLNALTATVLRVSQNGTSHESTAEEKPDSTPSK
                     PEHQNEASHPAHQDLAPEARPDSTKPDAKVADAENKPSQATADSQAEQPAQEAQASSV
                     KEAVRNESVENSSKENIPATPDRQAELPNTGIKNENKLLFAGISLLALLGLGFLLKNK
                     KEN"
     gene            4666..5079
                     /gene="rpsL"
                     /locus_tag="AC0DU4_001917"
     CDS             4666..5079
                     /gene="rpsL"
                     /locus_tag="AC0DU4_001917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002356190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HIN4237827.1"
                     /translation="MPTINQLVRKPRKSKVEKSKSPALNVGYNSHKKVQTNVSSPQKR
                     GVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKD
                     LPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA"
     gene            5099..5569
                     /gene="rpsG"
                     /locus_tag="AC0DU4_001918"
     CDS             5099..5569
                     /gene="rpsG"
                     /locus_tag="AC0DU4_001918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HIN4237828.1"
                     /translation="MSRKNRAPKRDVLPDPLYNSQLVTRLINRVMLDGKRGTAASIVY
                     GAFEQIKEATGNDALEVFETAMENIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLR
                     WLVTIARLRGEHTMQDRLAKEILDAANNTGAAVKKREDTHRMAEANRAFAHFRW"
BASE COUNT         1486 a         1100 c         1315 g         1793 t
ORIGIN      
        1 agcccattct tgggggtgga ttgcggaaga tggtgagcag gcggtgaaag attatttcca
       61 tccgactaag caagtggtgg atgctatttc caaagaccgt ccgcactggc aggaattgcg
      121 ttatgagcaa tatttggagc aggtagggcc aaatggcgcc atgtttgttg gcaatccaga
      181 tcaggtggcc gaaaaattga ttcgcatgat agaggattta ggattggacc gcttcatgct
      241 tcatataccg cttggttcta tgcctcatga ccaggttctg agagctattg aactcttcgg
      301 aacacaagtt gcaccaaaag tacgagctta ttttgctatg aaagaggctt aataaaaaat
      361 cctaatcaag tttattagga caacaaatat tgtacgaaaa ttaatccccc gagctataat
      421 gcttggggga tttttctata ggagggctag tttagttctc ttttttattt tttagtaaga
      481 aaccgagacc aaggagcgca aggaggctga ttcctgcaaa taggagtttg ttttcgtttt
      541 tgattcctgt atttggaagt tcagcttgtc tatctggggt tgcaggtata ttttccttgc
      601 tagagttttc taccgattcg tttcgaaccg cttcttttac agatgatgct tgtgcttctt
      661 gtgctggttg ttcagcttgt gaatcagctg tagcttggct aggtttattt tccgcatcag
      721 ctactttggc atctggttta gtagaatcag gtctagcttc tggagctagg tcttgatgtg
      781 cagggtgaga agcttcattt tgatgttcag gcttggaagg ggttgagtct ggtttctctt
      841 ctgcagttga ctcatggcta gttccatttt gagagactcg aagaacagta gctgtaaggg
      901 cattcaattt caagcctttt tcagtccatt caagtccttt cgggttggca attccgactg
      961 atcctgcttg gttttcatct gccaaaactt ccgcatttct tagatgtgca aaggcagttc
     1021 ccaaattaaa ttcgcgagct ttttcatccg cattgacaaa gactgcgtag atatcgccgt
     1081 ttggagcagt gatttggtag ccaatcacta catcctcttt ttccacacca ttttggcctg
     1141 ggacagtgat gaggtggaca cggtctttga tatcttggag actcttaagt cggaaggcat
     1201 ctgtagattg acgaagggca atcaaacctt tcatatagtc acggctcttg acattttcag
     1261 gataagcttt accatctgta gccttagtcc agtcaaactt gttgactgcg tcgctagaat
     1321 cgtaagaatc atggatgaag taaggatagt caaatgggtt gccgtcctta tcacgcaaca
     1381 agtgagattt gtttggaacc ttatcctctg ctactggagt cttgtaggct gggtcacgga
     1441 attgtttagt acgtccatat tcctgaccgg agtggataaa tggagttcct tgagctgtca
     1501 agaccatgag atttccaagt cgtaaacgac ggtggatttc agcatagttc tcagccttgc
     1561 ttgggtcttt tttgatagac tgggcaatga tgtcaaagag ggtcaagtta tcatgggctg
     1621 ctatgtattg gatgacatct ccagggctgt cagcttcaaa gttagttggt tgagcaatga
     1681 gatttttaaa gatggtgttg acatcacgct tgccacctgt gataaaggca ggttgacctt
     1741 cgtttggata accagatttg aggttgttac ggatgtcatc tgaaaagaca gcgacagtat
     1801 cggtatgttt catccaatct tggtcagcag ctttagtagg catgttttca tcaccggcat
     1861 aggttctcca accttcacca agcatgatga ggtttggatt gagggcgcgt gcagccttgt
     1921 aagcttcttc gatagaagcg gcgtcatggt ctcccatcat atcgaagcgg aagccatcca
     1981 ctttgtaggt atcaactagg tatttgatag agtcaactag gagccgtttg gtcatatggt
     2041 gggttgtccc caagcgtcca ccaccaaagc tagttcgagg tgtgccatcg gcatccataa
     2101 agtggtagta gtttggctct aggtcttcaa agatatcgac tttggctgtg tggttataaa
     2161 cgacatctag gatagctccc ataccacgtt tgtggatttc gttgatgagg tttttaaatt
     2221 ctgcgattcg tttttctgga ttcttaggat cgcttgagta cataccagtc aaggagaagt
     2281 agttttgagg gtcatatccc cagttgtagt tgctgttgct tgaagcatag tcagacaagc
     2341 gttcatggtt tttcaattca ttgacaaagt agtaagacaa gactggaagg agctggatat
     2401 gggttacacc caagtctttg agatagtcta gtttttcaat gaaggcttca aaagtcccaa
     2461 atggtttggt caagtctttt gcaatggcag gatctgaagt gaagtcacgc acatgagctt
     2521 cgtagataac ggcgtcttca cgagtcttga aattgtgaat cttaccataa gtcaagtctt
     2581 gaggtccgag tttagctgga tctacaaagg cggctttagc cactttatgg gcatcgtcaa
     2641 tcttggcatc gtcgctattc caagcagcaa gagatttagc gtaaggatcg agtgcaagaa
     2701 cagttttacc ttgacgctcg atttggtatt gataatagta gccagtgaaa tctgtgattc
     2761 cgagtttgtt tgtgctgtct agagtttgtt tccaagttcc tctttcccct ttttcgagag
     2821 cgacagttcc aactactttg tcagggtcat tcttgtcgta gacaacaaca gaaaccttat
     2881 cagcacttgg tgaccaaagg gtcaaatcaa cttgttttcc ttcttctttt aggtcagctc
     2941 ccagtttgcc atcatagctg tatgtctcat ctttcaggtg ccagcttgtt ttggtagtga
     3001 attggtcgga attgtagcta acagtataag gatgttttgt gtcagagaaa tctccgctgt
     3061 aggtcacttt cttaccagct tcatcgattg caacatcggt aatagttacc ttgtttccta
     3121 ggtgattagt gatgttggag tgtttgagga tatcttcttt tttagcaccg acaagtgttg
     3181 aaaagctact ttcaatgcta gaagtgccta cgtgttgggc tcctgtcata cggatatcat
     3241 ggacatagta tggatttgtg taaatcgatt catcatcgtc ttttaggaaa atttggctat
     3301 gatttttcaa atctgtgaac ttataatttt ctttacggat tttcacgtcg tctccttgtt
     3361 tgctctcatc tagtaataaa aatccaaatt ctcttgcggc ttcattaaga ggaatgtcga
     3421 tatagcggcc atatttgcct gtagccgtaa agtctgttcc gtcaggccat tgagcgctac
     3481 ttggattttt cacatctccc cagtaccaga gagatttctt gtcatagttg ccatctgtgc
     3541 ggtagtagtt gacgcgaaca gttcctgcag gctgtggctc gtaagagaaa accttgtaat
     3601 cttggtctaa ccaagcctcg ttcatttttg gaactagttt ttctacagat ttatcgccgg
     3661 ttagattttt tccagctgta ttgttgatga ggaagctaat tttcttggct tgttctccct
     3721 ttaatttgac atctaggtaa tagccgtagt catctttctt ggcatccttg aaggacaaag
     3781 ctccgtttgg ccagttttca gatggttttt caacatcgtc ccaagtccat agtccttgag
     3841 catccttgtt ttcttcagga agttttttga catggatacg gaagtagtta tcttcgatgg
     3901 gctcttctgc cttagtttca gttgttactg gactagtaga agtagttggc tctgttgcag
     3961 gtttttcttc tgttttctct agggaagcgt ttgcatttct aggtgaagaa atatcacttt
     4021 cgttcttacc agagccagct gctgtatcag taagaggttg ggcaagggtg gttgtatttc
     4081 tgttgttggg ttcgttagtg gttggtgtac tttcgtcgga tgagatagtt ggtgtagcca
     4141 tggcaagcaa gacaaggctt gcgccgataa ggacagaacc agttccattt ttgagggaac
     4201 ggatgctgta gaccattttt ttctcagtgt gagatggtgt ttttctcata atgattctcc
     4261 aatcaataaa tttctatatc agtatagcat gtagtaaaac aatatgcaag cgttttcttt
     4321 gatttgtgaa aaaaattctt acttttgaga agttttctgt actattttat atatcagtat
     4381 aaatgacgga gataaaaatg tcacataagc caagccgtat tattaggaag atgatgtgtt
     4441 cccagctatt tttattcaga aattgatctc taacattacc aataaaaaag aaaaatatct
     4501 tgacaaacaa gggaaaattt tgttacaata atagacggta ctttttactt ttggtctctc
     4561 aagagtgtac agggacgtgc tgacaaatgt tgcaaaagta cacacagatg atatctgtca
     4621 ccaagtgtat catcaccaaa aataaaaaaa cacaggagaa tgtagatgcc tacaattaac
     4681 caattggttc gcaaaccgcg taaatcaaaa gtagaaaaat ctaaatcacc agctttgaac
     4741 gttggttaca atagtcataa aaaagttcaa acaaacgttt cttcaccaca aaaacgtggt
     4801 gttgcaactc gtgttggaac aatgacacct aaaaaaccta actcagccct tcgtaaattc
     4861 gctcgtgtac gtttgagcaa ccttatcgaa gttactgcct acatcccagg tatcggacac
     4921 aacttgcaag agcacagcgt ggtgcttctt cgcggtggac gtgtaaaaga ccttccaggg
     4981 gtacgttacc atatcgtccg tggtgcactt gatactgcag gtgttaacga tcgtaaacaa
     5041 ggtcgttcta aatacggtac taaacgtcca aaagcataag gaaaggggat aaagagaaat
     5101 gagtcgtaaa aatagagctc caaaacgtga cgtattgcca gatccgctat acaattcaca
     5161 actagttact cgtcttatca accgcgttat gcttgatggt aaacgtggta ctgctgcttc
     5221 aatcgtttac ggtgcttttg agcaaatcaa agaagctact ggcaacgatg cacttgaagt
     5281 atttgaaaca gctatggaaa acatcatgcc tgtacttgaa gtacgtgcac gtcgtgttgg
     5341 tggttctaac taccaagtcc cagttgaagt tcgtccagaa cgtcgtacaa cacttggact
     5401 tcgttggttg gtaacaatcg ctcgtcttcg tggtgaacac acaatgcaag accgtcttgc
     5461 aaaagaaatc ttggatgctg ctaacaacac tggtgcagca gttaagaaac gtgaagatac
     5521 tcaccgtatg gctgaagcta accgtgcatt cgcacacttc cgttggtaag ataggatgcg
     5581 aaagcgttaa gaaagtccca gagaaaatag ggaatcgaag caggttgcgg ttgcaaccaa
     5641 tgagattcat ctttttctcc agacttttag cttgagctca actaaatcat gatg
//
LOCUS       DBMVGT010000091         5655 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.091, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000091 DBMVGT010000000
VERSION     DBMVGT010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5655)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5655)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5655
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.091"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            32..292
                     /locus_tag="AC0DU4_001919"
     CDS             32..292
                     /locus_tag="AC0DU4_001919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237829.1"
                     /translation="MRERSATGAQDLSKSIKKHLNDITRLTASLLGDEKLSAIISSSA
                     VKADMHRFVIELEPVKSTILQNDDISLDQNEIFEILKNFLDG"
     gene            complement(1056..1346)
                     /locus_tag="AC0DU4_001920"
                     /pseudo
     CDS             complement(1056..1346)
                     /locus_tag="AC0DU4_001920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(1324..1455)
                     /locus_tag="AC0DU4_001921"
     CDS             complement(1324..1455)
                     /locus_tag="AC0DU4_001921"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237830.1"
                     /translation="MNYEASKQLTDTRFKRLVGVQRTTFEEMLAVLKTAYQKSRTSW"
     gene            1580..2038
                     /locus_tag="AC0DU4_001922"
     CDS             1580..2038
                     /locus_tag="AC0DU4_001922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000186958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4231 domain-containing protein"
                     /protein_id="HIN4237831.1"
                     /translation="MTPEEMYLTERLDVQIAHFLKKSVQHRRRYKVLKITEIVAGFLI
                     AVFCAIPMPGDRYRLISVALSSLGLLCEGIINLYNAKENWISYQKTAQLLEKEKFLYQ
                     CQTEKYAGKTKAFALFVKTCEGLISEEINQWESIQSKEVAASADAPVKKE"
     gene            2051..2659
                     /locus_tag="AC0DU4_001923"
     CDS             2051..2659
                     /locus_tag="AC0DU4_001923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237832.1"
                     /translation="MSQSSYLSPLLWLKKEADKEKMSATQCQIFFFYYQMFELLFARE
                     SDMKDLCLGTKGFYFSQLEKNLLSGVSRFLKNLEGKVTLKANQEVSARKALFLALTTS
                     QSDWQELAPVFDFYQTIGRLENPSLLSSQDRQHLMWIYQSALEKDYIVKVIGDKHFVL
                     KRQDATKLTARQTQTLEILSQSEDLVNPVYVTLGEKGVLLLD"
     gene            2652..3062
                     /locus_tag="AC0DU4_001924"
     CDS             2652..3062
                     /locus_tag="AC0DU4_001924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237833.1"
                     /translation="MIKRGDVVALYLPFPTISSDLAVKNHMYICIDNSMTKNKELVKN
                     QTFKPALLTRRLVKNFMIEEPDLARNPFTRPTLIDLDKVFMLDNTVIPTSYLARRRRN
                     VSEELYEEILDHLVQPRLISLNKSEFMQLNPGTY"
     gene            3073..4488
                     /gene="ply"
                     /locus_tag="AC0DU4_001925"
     CDS             3073..4488
                     /gene="ply"
                     /locus_tag="AC0DU4_001925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cholesterol-dependent cytolysin pneumolysin"
                     /protein_id="HIN4237834.1"
                     /translation="MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFV
                     VIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSID
                     LPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQ
                     LKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTV
                     TVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQT
                     EWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTS
                     FLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWDELSYDHQGKEVL
                     TPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRK
                     RTISIWGTTLYPQVEDKVEND"
     gene            5369..>5655
                     /locus_tag="AC0DU4_001926"
     CDS             5369..>5655
                     /locus_tag="AC0DU4_001926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015604432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HIN4237835.1"
                     /translation="MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPESN
                     SALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFTEGRYEGFGPNGSMLIV"
BASE COUNT         1767 a          965 c         1197 g         1726 t
ORIGIN      
        1 aattattttt aaggctaaag cttggctgga tatgagagag cgctctgcta caggtgctca
       61 agatttaagt aagtccatta aaaagcattt gaatgacatt acccgtttga cagcttcctt
      121 gctaggagat gaaaagttat cggctataat atcaagtagt gcggtaaaag cagacatgca
      181 ccgctttgtg atagaattag agcctgtgaa gtcaactatt cttcaaaatg atgacatttc
      241 attggatcaa aatgaaattt ttgaaattct gaaaaatttt ctcgatggtt aaaataattg
      301 tagcgagatg gctatattga attcgtctat atctggaaac tagaaaaaac ttcaatttca
      361 ggagaaaatg aagtcaatct tcccacaatc aaacgtatag tatcaaggtt tttcaagacc
      421 tgatattatg cgttttttgc ttttcaaaac tttttgccca gtctttgttt ttatcctcta
      481 gtcacttgat ttgtttcagg tggtttttta gtatagtaaa atgaaacgag aacaggacaa
      541 attgatcagg acagtcaaat cgatttctaa caatgtttta gaagcagaag tgtactattc
      601 tagtttcaat ctactatagt taaatctgcg gtcaagtcta ctggtgaatc tatgattgta
      661 atactcttcc aaaatctcat caaccacgtc agtcttgcct tgcagtctgt atcttactga
      721 ccaagctagt gatggactta gaataggtga tttggagcgt cctattggct aggaaatgct
      781 gatcatagtc ctttgctgag gctagggtgt ttcaacattc aacactcaac tggttgatct
      841 agttgatagg aagggaatta ctataaaata ctcaggcttc catcatattt tttgaaacga
      901 ttgtgtaatc aaaatgtacc aatattgtag tattggtaca gaagatgttg tgaatggata
      961 aatatatcat aactgctgtc tctctatgta aaaagaaggc tgtatcaaaa agatttcata
     1021 tgtctgtgca tatatataat agacttcctg caaaactaga atcctagttc atgattgata
     1081 ataccagcac tcaaattcat tcgtaatccg aagcgtttac gatgatttcg acaggttgtt
     1141 gaaaacattt taaacgtttt tactttggca aagatgttct caaccttgct tctctcctta
     1201 gatagcgcat ggttatagac tttatcttca actgttagtg gcttgagttt gctggattta
     1261 cgtggagttt gtgcttgagg atatatcttc atgagccctt gataattact gtcagccaag
     1321 attttaccag cttgtccgac ttttttgata agctgttttt aatacagcta acatctcttc
     1381 aaaagtggta cgctgaacac caacaagacg cttaaatcgt gtatcagtta attgtttact
     1441 tgcttcataa ttcatagaac tactatacca tattttgttt cgcagggagt ctaataagtt
     1501 atagtccagt ttttactata ctttgatatt caaatatgtt atactatggt tatcaaagta
     1561 aatgaaagga gttacgaata tgacgccaga agaaatgtac ctgacagagc gattagacgt
     1621 acagatagct cattttttaa agaaaagcgt tcaacatcgt aggcgctata aggtattaaa
     1681 aataacagaa atcgtggcag gtttcctcat agctgtcttt tgtgctattc ctatgccagg
     1741 tgatcgctac cgtttgattt cggttgcctt atccagtctc ggcttgctgt gtgaggggat
     1801 tatcaatttg tataatgcaa aggaaaattg gatttcttac caaaaaactg cgcaactcct
     1861 ggagaaagaa aaattcctct atcaatgcca aacggagaaa tatgcaggaa agaccaaggc
     1921 ttttgcccta tttgtcaaga catgcgaagg tcttatctca gaggagatta accagtggga
     1981 aagtatccag tcaaaagaag tggcagctag tgcagatgct ccagttaaaa aagagtagga
     2041 ggtagaggaa atgtctcaat ccagctacct gtcgcccttg ctctggttaa aaaaagaagc
     2101 cgataaggaa aagatgagcg cgacccagtg ccagatattt ttcttttact atcaaatgtt
     2161 tgagctctta tttgctagag aaagcgacat gaaagactta tgtctgggaa cgaaaggttt
     2221 ttatttctcg cagttagaga aaaatttgct ttctggagtt tcccgatttc taaaaaactt
     2281 ggaggggaaa gtaactctca aggctaacca agaagtatca gctcgcaaag ccctttttct
     2341 agccttgaca actagccaat cagattggca ggagttagct cctgtttttg atttttatca
     2401 gactatcggg aggcttgaaa atccttctct cttgagttct caggacagac aacatctgat
     2461 gtggatttac cagtcagctt tggagaagga ttatattgtc aaggttattg gcgacaagca
     2521 ttttgtattg aagagacaag atgctactaa attgacagcg cgccaaactc aaactttgga
     2581 aattctgagt caatcagaag acttggtcaa tcctgtctat gttacattag gagaaaaggg
     2641 ggtgctcttg cttgattaag agaggagatg ttgtagctct ttatttgcct tttccgacta
     2701 ttagtagcga tttggctgtg aagaatcata tgtatatctg tattgacaac agcatgacta
     2761 aaaacaaaga gttggttaaa aatcagacct tcaaaccagc tctcttgacc agacgtttgg
     2821 tcaagaactt tatgatagaa gagccggatc tagctcgtaa tccttttaca agaccaacct
     2881 tgattgactt agataaggta tttatgttgg ataatacggt tattccgact tcttatctag
     2941 ccagacggcg acgcaatgtc tcagaagaat tgtacgagga aattttggat cacttagtcc
     3001 aaccacggct gatttcgctg aacaagtctg agtttatgca actcaatcca ggaacttatt
     3061 aggaggtata agatggcaaa taaagcagta aatgacttta tactagctat gaattacgat
     3121 aaaaagaaac tcttgaccca tcagggagaa agtattgaaa atcgtttcat caaagagggt
     3181 aatcagctac ccgatgagtt tgttgttatc gaaagaaaga agcggagctt gtcgacaaat
     3241 acaagtgata tttctgtaac agctaccaac gacagtcgcc tctatcctgg agcacttctc
     3301 gtagtggatg agaccttgtt agagaataat cccactcttc ttgcggtcga tcgtgctccg
     3361 atgacttata gtattgattt gcctggtttg gcaagtagcg atagctttct ccaagtggaa
     3421 gaccccagca attcaagtgt tcgcggagcg gtaaacgatt tgttggctaa gtggcatcaa
     3481 gattatggtc aggtcaataa tgtcccagct agaatgcagt atgaaaaaat cacggctcac
     3541 agcatggaac aactcaaggt caagtttggt tctgactttg aaaagacagg gaattctctt
     3601 gatattgatt ttaactctgt ccattcaggc gaaaagcaga ttcagattgt taattttaag
     3661 cagatttatt atacagtcag cgtagatgct gttaaaaatc caggagatgt gtttcaagat
     3721 actgtaacgg tagaggattt aaaacagaga ggaatttctg cagagcgtcc tttggtctat
     3781 atttcgagtg ttgcttatgg gcgccaagtc tatctcaagt tggaaaccac gagtaagagt
     3841 gatgaagtag aggctgcttt tgaagctttg ataaaaggag tcaaggtagc tcctcagaca
     3901 gagtggaagc agattttgga caatacagaa gtgaaggcgg ttattttagg gggcgaccca
     3961 agttcgggtg cccgagttgt aacaggcaag gtggatatgg tagaggactt gattcaagaa
     4021 ggcagtcgct ttacagcaga tcatccaggc ttgccgattt cctatacaac ttctttttta
     4081 cgtgacaatg tagttgcgac ctttcaaaat agtacagact atgttgagac taaggttaca
     4141 gcttacagaa acggagattt actgctggat catagtggtg cctatgttgc ccaatattat
     4201 attacttggg atgaattatc ctatgatcat caaggtaagg aagtcttgac tcctaaggct
     4261 tgggacagaa atgggcagga tttgacggct cactttacca ctagtattcc tttaaaaggg
     4321 aatgttcgta atctctctgt caaaattaga gagtgtaccg ggcttgcctg ggaatggtgg
     4381 cgtacggttt atgaaaaaac cgatttgcca ctagtgcgta agcggacgat ttctatttgg
     4441 ggaacaactc tctatcctca ggtagaggat aaggtagaaa atgattagga gagaagaatg
     4501 tttgcgacaa aaagaggcga tgagctctct gcgaatatct gaaagtttat ctcttgccta
     4561 gcgatttcca ttggagtatg ctcgtgatgt taaaatgaat ctatcaaaca gaatgtgtaa
     4621 aaaagtaaaa agggtagcca attccttgat atacagggga ttgattatcc tttacttgtt
     4681 ttagatgatt ggaaattcaa gaatgacacg tatcggaaat attttgctgt ttatatctaa
     4741 tacccattta tggaaaaaat gaaattaaat atgaacaaat caattgctag caatggttta
     4801 gaagtgccag tgtactagtc taatttctcc atcttgggaa cacgtaaatt atactcttcg
     4861 aaaatctctt caaaccaggt cagtcctatc cgcaacctca aaacagtgtt ttgagcaacc
     4921 tgcggctagc tttctagttt gctttttgat ttttattgag tattagaggt ttgcttagaa
     4981 actcttctat tgatttctta gaatacaata gcgcctataa gaactgttga atttcaaagt
     5041 atttacttga actatgatat gtctggagta gactgtcaac aaaaggtgca gtatgattgt
     5101 ttttgtcgct tatatctaca aacttcaaac agtaatttga gctgactttg tcaaacttgg
     5161 ctgaaacttt ctatttgcag ataatggtct agtttgtttt ttgaatgtgg atgagtgtct
     5221 gttgataaag atagaaaggc aagaccatct tagcaggtaa agtgctatcc tagcttgatt
     5281 tgctaataaa atccatttcc tctagtgaaa atcaaaaaaa cttgtgttat aataagaaag
     5341 attaaaatgt gaaaaaagga gattcctaat gggacgtaaa tgggccaata tcgtagccaa
     5401 gaaaacggct aaagatggag ctaactctaa agtatatgca aaatttggtg tagaaatcta
     5461 tgtagcagct aaaaaaggtg atccagatcc agaatcaaac tcagctttga aattcgttat
     5521 cgaccgtgct aaacaagccc aagtgccaaa acacattatc gataaagcga ttgataaagc
     5581 caaaggaaac acagacgaaa cctttacaga aggacgttac gaaggttttg ggccaaatgg
     5641 ctctatgcta attgt
//
LOCUS       DBMVGT010000092         5356 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.092, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000092 DBMVGT010000000
VERSION     DBMVGT010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5356)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5356)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5356
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.092"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1037)
                     /gene="recF"
                     /locus_tag="AC0DU4_001927"
     CDS             complement(<1..1037)
                     /gene="recF"
                     /locus_tag="AC0DU4_001927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000266665.1"
                     /note="All proteins in this family for which functions are
                     known are DNA-binding proteins that assist the
                     filamentation of RecA onto DNA for the initiation of
                     recombination or recombinational repair; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology.
                     GO_function: GO:0003697 - single-stranded DNA binding
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA];
                     GO_process: GO:0009432 - SOS response [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HIN4237836.1"
                     /translation="MWLQHLSLKTFRNYKETKIDFNPKLNVFLGRNAQGKTNMLEAIY
                     FLALTRSHRTRTDKNLIHFDEEQLHLSGLVQKKTGSIPLEIELTQKGRVTKVNHLKQA
                     RLSDYVGHMNVVLFAPEDLQLIKGAPSIRRKFIDMELGQIKPIYLSDLTNYNHILKQR
                     NTYLKSDQKIDETFLSVLDDQLVDYGCRVMNHRLDFIKKLESFGRKKHFELSNQIEEL
                     SISYQSSVNITDKQNLSESFKIALEKSKSRDLFKKNTGVGPHRDDISFYINGMDASFG
                     SQGQHRSLVLSIKLAEIELMESITTESPILLLDDVMSELDNTRQLKLLETISQSIQTF
                     ITTTSLDHLQNL"
     gene            complement(1040..1408)
                     /gene="yaaA"
                     /locus_tag="AC0DU4_001928"
     CDS             complement(1040..1408)
                     /gene="yaaA"
                     /locus_tag="AC0DU4_001928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S4 domain-containing protein YaaA"
                     /protein_id="HIN4237837.1"
                     /translation="MEYKLFEEFITLQALLKELGITHSGGAIKSFLSEHSVYFNRELE
                     SRRGKKLRIGDKVDIPDMNIDILLTQPTSEEQDEYQADKVEKERIAKLVKKMNKGVKK
                     DKSKPASSPKSQQAPRFPGR"
     gene            1567..2817
                     /gene="yfmF"
                     /locus_tag="AC0DU4_001929"
     CDS             1567..2817
                     /gene="yfmF"
                     /locus_tag="AC0DU4_001929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EF-P 5-aminopentanol modification-associated
                     protein YfmF"
                     /protein_id="HIN4237838.1"
                     /translation="MELVHGISTHFIQSKKFKTNKITVRFTAPLSLDTIAGHMLSASM
                     LETANQMYPTSQDLRRHLASLYGTDMSTNCFRRGQSHIIELTFTYVRDEFLSRKNVLT
                     SQILELVKETLFSPVVVDNGFDPALFEIEKKQLLASLAADMDDSFYFAHKELDKLFFH
                     DERLQLEYSDLRNRILAETPQSSYSCFQEFLANDRIDFFFLGDFNEVEIQNVLESFGF
                     KGRKGDVKVQYCQPYSNILQEGMVRKNVGQSILELGYHYRSKYGDEQHLPMIVMNGLL
                     GGFAHSKLFTNVRENAGLAYTISSELDLFSGFLRMYAGINRENRNQARKMMNNQLLDL
                     KKGYFTEFELNQTKEMIRWSLLLSQDNQSSLIERAYQNALFGKSSADFKSWIAKLEQI
                     DKDAICRVANNVKLQAIYFMEGIE"
     gene            2814..4097
                     /gene="yfmH"
                     /locus_tag="AC0DU4_001930"
     CDS             2814..4097
                     /gene="yfmH"
                     /locus_tag="AC0DU4_001930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EF-P 5-aminopentanol modification-associated
                     protein YfmH"
                     /protein_id="HIN4237839.1"
                     /translation="MTKVVFEEKYYPAVKEMVYRTRLANGLTVALLPKKEFKEVYGSV
                     TVQFGSVDTFVTEVDGDVKQYPGGIAHFLEHKLFEREDSSDLMSAFTSLGADSNAFTS
                     FTKTNYLFSATDYFLENLDLLDELVTSAHFTEASILTEQDIIQQEREMYQDDPDSCLF
                     FSTLANLYPGTPLATDIVGSEESISQINLTNLQENFTKFYKPVNMSLFLVGNFDVERV
                     QDYFESKELKDSDFQEVAREKLFLQPVKPTDSMRMEVSSPKLAIGVRGKREVSEADCY
                     RHHILLKLLFAMMFGWTSDRFQKCYESGKIDASLSLEVEVTSRFHFVMLTMDTKEPVA
                     LSHQFRKAIRNFTKDLDITEEHLDIIKREMFGEFFSSMNSLEFIATQYDAFENGETIF
                     DLPKILQEITLEDVLDAGHHLIDDGDIVDFTIFPS"
     gene            4139..4960
                     /gene="rodZ"
                     /locus_tag="AC0DU4_001931"
     CDS             4139..4960
                     /gene="rodZ"
                     /locus_tag="AC0DU4_001931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytoskeleton protein RodZ"
                     /protein_id="HIN4237840.1"
                     /translation="MRKKTIGEVLRLARINQGLSLDELQKKTEIQLDMLEAMEADDFD
                     QLPSPFYTRSFLKKYAWAVELDDQIVLDAYDSGSMITYEEVDVDEDELTGRRRSSKKK
                     KKKTSFLPLFYFILFALSILIFVTYYVWNYIQTQPEEPSLSNYSVVQSTSSTSSVPHS
                     SSSSSSSIESAISVSGEGNHVEIAYKTSKETVKLQLAVSDVTSWVSVSESELEGGVTL
                     SPKKKSAEATVATKSPVTITLGVVKGVDLTVDNQTVDLSKLTAQTGQITVTFTKN"
     gene            4971..>5356
                     /gene="pgsA"
                     /locus_tag="AC0DU4_001932"
     CDS             4971..>5356
                     /gene="pgsA"
                     /locus_tag="AC0DU4_001932"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008444 -
                     CDP-diacylglycerol-glycerol-3-phosphate
                     3-phosphatidyltransferase activity [Evidence IEA];
                     GO_process: GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HIN4237841.1"
                     /translation="MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVA
                     SITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRE
                     LAVTGLRLLLVETGGTILAAAMPGKI"
BASE COUNT         1680 a          785 c         1068 g         1823 t
ORIGIN      
        1 agattttgaa gatggtctaa gcttgttgtt gtgataaagg tttggattga ttgagaaatc
       61 gtttctaata attttaattg tctagtgttg tcaagttcac tcatcacatc gtcaagcagt
      121 aatataggag attctgtggt aatgctttcc attaattcga tttctgctaa ttttatcgag
      181 aggacgagac tacgatgttg accttggctt ccgaaactag catccatccc atttatataa
      241 aaagaaatgt catctcgatg aggaccgaca ccagtattct ttttaaataa atctctggat
      301 ttactttttt ctaaagcaat tttgaaagat tcggataagt tttgtttgtc agttatattg
      361 acagaagatt gataggatat tgacaactct tcgatctgat tagagagttc aaaatgtttc
      421 ttacgcccaa atgattctag tttttttatg aaatctaagc ggtgattcat tacacgacat
      481 ccataatcaa ctagctgatc atctaacaca gaaaggaatg tttcatctat tttttgatct
      541 gattttaggt aagtgtttct ttgctttagg atgtggttat aattggttaa gtcagataag
      601 tagattggct taatttgccc aagttccata tcgatgaatt ttcgtcgaat cgaaggtgct
      661 cctttaatta gttgtaaatc ttcaggagca aataagacaa cattcatgtg tcctacataa
      721 tctgaaaggc gtgcctgttt taagtgatta acttttgtta cacggccttt ttgtgttagt
      781 tcgatttcta ggggaatgga tccagttttt ttctgaacga gacctgaaag atgaagttgt
      841 tcctcatcaa aatgaatgag atttttatct gttcgagttc gatgactacg cgttaaggct
      901 aaaaaataga tagcctctaa catgtttgtt tttccttgtg cattacgtcc caaaaagaca
      961 ttcaatttag gattaaagtc tattttcgtt tctttgtaat tacgaaaagt cttgagagat
     1021 agatgttgta gccacatgat tatctaccag ggaatcgtgg agcttgttgg cttttaggtg
     1081 atgaagcagg tttcgatttg tcttttttaa ctcccttatt catctttttg acaagtttag
     1141 cgatccgttc tttttcaact ttatcagctt ggtattcatc ttgttcttca gaagtaggtt
     1201 gtgtcaacaa gatgtcaatg ttcatgtcag ggatgtcaac tttatcgcca atacgaagtt
     1261 tttttccacg acgactctct aattccctat taaagtaaac agaatgttca gagagaaatg
     1321 atttaatagc tcctccgcta tgtgtaattc caagttcttt gagtagtgct tggagggtaa
     1381 taaattcttc aaataatttg tattccataa ttcacctcaa tctttggtat tataccatat
     1441 tttcctaaaa atagtgagag agacagcgag aaatgtaagc gatttttatt tcaaaagtgt
     1501 tacagggaac aagaaaattt caggttttcg tgatataata gaagtctgta tataaggagg
     1561 taaatcatgg agttagtgca tggaatttca acacatttta tccaatcaaa aaagtttaaa
     1621 acaaacaaaa ttaccgtgcg ttttaccgct ccattatccc ttgatacgat tgcaggtcac
     1681 atgttgagtg caagtatgct agagactgct aatcagatgt accccacttc tcaagatttg
     1741 aggagacact tggccagtct atacggtaca gatatgtcaa ccaattgttt cagaagaggg
     1801 caaagccaca ttatagaatt gacatttacc tatgttcgtg atgagttttt aagtaggaaa
     1861 aacgtgctaa cctctcagat tttggaactt gtaaaagaaa ctcttttttc acccgtagta
     1921 gttgataatg ggtttgatcc ggccttattt gaaattgaga aaaaacaatt gctagcaagt
     1981 ttagcagctg atatggatga ttctttttat tttgcacata aagaattgga taaattgttt
     2041 tttcatgatg aacgtcttca attggaatat agtgatttac gaaatcgtat tttagctgaa
     2101 actccacaaa gttcttactc ttgtttccaa gaatttttag ccaatgatcg aatagatttc
     2161 tttttcctag gtgattttaa tgaggttgaa attcaaaatg tattagaatc atttggcttt
     2221 aaaggtcgaa aaggagatgt gaaggttcag tattgtcaac cttattctaa tatccttcag
     2281 gaaggtatgg ttcggaaaaa tgtgggacaa tccattttgg aattaggtta tcattaccgt
     2341 tctaaatatg gtgatgaaca acatttaccc atgattgtaa tgaatggttt acttggtgga
     2401 tttgctcact ctaagctctt tacaaatgtc cgtgaaaatg ctggattagc ttataccatt
     2461 tcaagtgagc ttgatttatt tagtggattc ttgaggatgt atgctggtat caatcgagaa
     2521 aatcgtaacc aggctcgtaa aatgatgaat aatcaactgc ttgatttaaa aaaaggttat
     2581 tttacagagt ttgagttaaa tcagaccaag gaaatgattc gttggtcgtt gttactttct
     2641 caagataatc aatcttcatt gattgaacgt gcttatcaaa atgccttatt tggaaaatct
     2701 tcagcagact ttaaaagttg gattgcaaag cttgaacaaa ttgacaaaga tgctatttgt
     2761 agagtagcta ataatgtgaa actacaagcg atttacttta tggaaggaat agaatgacaa
     2821 aggttgtttt tgaagaaaaa tactatccag ctgtaaaaga aatggtttat cgaactcgtt
     2881 tggccaacgg attgacagtt gctcttttgc ctaaaaagga atttaaagag gtttacggga
     2941 gtgtcactgt acagtttggt tcggtagata cgtttgtcac agaagttgac ggagatgtaa
     3001 aacaatatcc tggaggaatt gctcattttc ttgaacataa attatttgag agagaagatt
     3061 ctagtgattt gatgtcggct tttacgagtc taggtgcaga tagtaatgcc tttacaagct
     3121 ttacaaaaac aaactatctt ttttcagcaa cggattattt tttagaaaat ttagatttac
     3181 ttgatgaatt ggtaacatca gcacacttta ctgaagcttc cattttgaca gagcaggata
     3241 ttattcagca agaacgagaa atgtaccaag atgatccaga ttcgtgttta ttcttttcaa
     3301 ctttagcgaa tttgtatcct ggtacacctt tagcaactga tatagttgga agtgaggagt
     3361 ccatttccca aatcaatcta actaatttgc aagaaaattt tacaaagttt tacaaacctg
     3421 taaacatgtc tctgttttta gttggtaatt ttgatgtgga gcgagtacag gactattttg
     3481 aaagcaaaga actgaaagat tcagattttc aggaagtagc aagagaaaag ttgtttttac
     3541 agcctgtaaa gccaacagat agtatgagaa tggaagtatc ttctcccaaa ctagcgattg
     3601 gagttagagg taagcgagaa gtttctgaag cggattgcta tcgacatcat attttattaa
     3661 aattattgtt tgcaatgatg tttggttgga cttcggatcg ttttcaaaaa tgttatgaat
     3721 caggtaaaat tgatgcatcc ttatctctgg aagttgaagt aacaagtcgc tttcattttg
     3781 tcatgttgac aatggatacg aaagagccag ttgctttgtc tcatcaattt aggaaggcta
     3841 ttcgtaattt tacaaaggat ttagatatta cagaggaaca tttagatatt atcaaaagag
     3901 agatgtttgg cgaatttttc agtagcatga actctcttga atttattgca acgcaatatg
     3961 atgcttttga aaatggtgag acaatttttg atttgccgaa aattttacag gaaattactt
     4021 tagaggatgt ccttgatgct ggacatcatt taatagatga tggtgacata gttgatttta
     4081 caatattccc atcgtagtaa cctattataa tagacactag aaagaaggga tgacaagtat
     4141 gagaaaaaaa acaattggag aggttttacg attagctaga atcaatcagg gattgagttt
     4201 agatgaattg cagaaaaaga cagaaatcca gttagatatg ttggaagcaa tggaagcaga
     4261 cgatttcgat caacttccaa gtccttttta cacgcgttct ttcttgaaaa aatatgcatg
     4321 ggctgttgag ttagatgacc aaattgtttt ggatgcttat gattctggga gtatgattac
     4381 ttatgaggaa gtagatgttg atgaagatga gttgacaggt cgtagacgtt caagtaagaa
     4441 aaagaagaaa aaaacatcat ttttaccttt attttatttt atcctttttg ctttatcgat
     4501 tttaattttt gtgacttatt atgtttggaa ctatattcaa actcaaccag aggagccttc
     4561 tctttctaat tacagtgtgg ttcaatcaac aagttcaact agctctgttc cccactcctc
     4621 aagtagtagt tcttctagta tagaatcagc tataagtgta tcaggcgaag gaaatcatgt
     4681 agaaatcgct tataagacaa gtaaggaaac agttaaattg caattggcag tttcagatgt
     4741 tacaagttgg gtcagtgttt cagaaagcga acttgagggc ggtgtaacct tatcgccaaa
     4801 gaagaaaagt gcagaagcaa cagttgcaac taaaagtcct gtaacaatta cgttaggtgt
     4861 tgtaaaaggt gttgatttga cagtagataa tcagactgtt gatttatcga aattaacagc
     4921 tcagactgga caaatcactg taacctttac taaaaattaa ggaaaaacga atgaaaaaag
     4981 aacaaattcc caatctctta acaataggtc gaattctctt tatacctatt tttatcttta
     5041 ttttaacgat aggaaattcg atagagagtc atatagttgc agctattatc tttgctgttg
     5101 ccagtattac cgactattta gatggatatt tagctcgtaa atggaatgtg gtcagtaatt
     5161 ttggtaaatt tgcagatcct atggcggata agttactagt tatgtcggct tttattatgt
     5221 tgattgagtt aggtatggct ccggcttgga ttgttgcagt gattatctgt cgtgagttag
     5281 ctgtgacagg tttaaggctt ttattggttg aaactggtgg aacaatttta gcagcagcaa
     5341 tgcctggaaa aattaa
//
LOCUS       DBMVGT010000093         5277 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.093, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000093 DBMVGT010000000
VERSION     DBMVGT010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5277)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5277)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5277
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.093"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..375
                     /locus_tag="AC0DU4_001933"
     CDS             <1..375
                     /locus_tag="AC0DU4_001933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269806.1"
                     /note="with CbiNQ forms the ABC transporter for cobalt
                     import; Staphylococcus has two adjacent copies of this
                     gene; Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HIN4237842.1"
                     /translation="AGVVALRPAILILDEATSMLDPEGRRELIGTVKGIRKDYDMTVI
                     SITHDLEEVAMSDRVLVMKKGEIESTSSPRELFSRNDLDQIGLDDPFANQLKKSLSQN
                     GYDLPENYLTESELEDKLWELL"
     gene            360..1199
                     /locus_tag="AC0DU4_001934"
     CDS             360..1199
                     /locus_tag="AC0DU4_001934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000510406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HIN4237843.1"
                     /translation="MGIALENVNFTYQEGTPLASAALSDVSLTIEDGSYTALIGHTGS
                     GKSTILQLLNGLLVPSQGSVRVFDTLITSTSKNKDIRQIRKQVGLVFQFAENQIFEET
                     VLKDVAFGPQNFGVSEEDAVKTAREKLALVGIDESLFDRSPFELSGGQMRRVAIAGIL
                     AMEPAILVLDEPTAGLDPLGRKELMTLFKKLHQSGMTIVLVTHLMDDVAEYANQVYVM
                     EKGRLVKGGKPSDVFQDVVFMEEVQLGVPKITAFCKRLADRGVSFKRLPIKIEEFKES
                     LNG"
     gene            1192..1986
                     /locus_tag="AC0DU4_001935"
     CDS             1192..1986
                     /locus_tag="AC0DU4_001935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000377903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     component T family protein"
                     /protein_id="HIN4237844.1"
                     /translation="MDSMILGRYIPGDSIVHRLDPRSKLLAMMLLILIVFWANNPLTN
                     LILFIATGIFIALSGVSLSFFIQGLKSMFFLIAFTTIFQLFFISNGNVLFEFSFVRIT
                     DYALQQAGIIFCRFVLIIFFSTLLTLTTMPLSLASAVEALLAPLKRVKVPVHEIGLML
                     SMSLRFVPTLMDDTTRIMNAQKARGVDFGEGSIVQKVKAMIPILIPLFATSLKRADSL
                     AIAMEARGYQGGKGRSQYRQLKWTLKDTLTILVILVLGCCLFFLKS"
     gene            2045..2863
                     /gene="mreC"
                     /locus_tag="AC0DU4_001936"
     CDS             2045..2863
                     /gene="mreC"
                     /locus_tag="AC0DU4_001936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreC"
                     /protein_id="HIN4237845.1"
                     /translation="MNRFKKSKYVIIVFVTVLLVSALLATTYSSTIVTKLGDGISLVD
                     RVVQKPFQWFDSVKSDLAHLTRTYNENESLKKQLYQLEVKSNEVESLKTENEQLRQLL
                     DMKSKLQATKTLAADVIMRSPVSWKQELTLDAGRSKGASENMLAIANGGLIGSVSKVE
                     ENSTIVNLLTNTENADKISVKIQHGSTTIYGIIIGYDKENDVLKISQLNSNSDISAGD
                     KVTTGGLGNFNVADIPVGEVVATTHSTDYLTREVTVKLSADTHNVDVIELVGNS"
     gene            2863..3357
                     /gene="mreD"
                     /locus_tag="AC0DU4_001937"
     CDS             2863..3357
                     /gene="mreD"
                     /locus_tag="AC0DU4_001937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreD"
                     /protein_id="HIN4237846.1"
                     /translation="MRQLKRVGVFLLLPFFVLIDAHISQLLGSFFPHVHLASHFLFLF
                     LLFETIEVSEYLYLVYCFVIGLVYDVYFFHLIGITTLLFILLGAFLHKLNSVILLNRW
                     TRMLAMIVLTFLFEMGSYLLAFMVGLTVDSMSIFIVYSLVPTMILNFLWITVFQFIFE
                     KYYL"
     gene            3451..4629
                     /gene="pcsB"
                     /locus_tag="AC0DU4_001938"
     CDS             3451..4629
                     /gene="pcsB"
                     /locus_tag="AC0DU4_001938"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan hydrolase PcsB"
                     /protein_id="HIN4237847.1"
                     /translation="MKKKILASLLLSTVMVSQVAVLTTAHAETTDDKIAAQDNKISNL
                     TAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQ
                     SLEKQARSAQTNGAVTSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKA
                     ISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLL
                     EQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKV
                     RPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIA
                     CWNDGGYGHVAVVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVTYIYAD
                     "
     gene            4853..>5277
                     /gene="rpsB"
                     /locus_tag="AC0DU4_001939"
     CDS             4853..>5277
                     /gene="rpsB"
                     /locus_tag="AC0DU4_001939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HIN4237848.1"
                     /translation="MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQ
                     QTVKYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLT
                     NWGTIQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRA"
BASE COUNT         1654 a          854 c         1148 g         1621 t
ORIGIN      
        1 gcaggtgttg tagccctaag accagctatt ttaatcttag atgaagcaac gagtatgttg
       61 gatcctgagg ggcgtagaga acttattggg acagtaaaag gaattcgaaa agactatgat
      121 atgacggtca tttctattac ccatgatttg gaagaagtcg ccatgagtga tcgcgtattg
      181 gtcatgaaaa aaggggaaat tgaatcaact agtagtccaa gggagctttt ctctcgaaat
      241 gatttagatc aaattggatt agacgatcct tttgctaatc aattaaaaaa atctttgagc
      301 cagaatggct atgatttacc tgaaaattat ttgacagaaa gtgagctaga ggataagcta
      361 tgggaattgc tctagaaaat gtgaatttta catatcaaga aggtactccc ttagcttcag
      421 cagctttgtc ggatgtttct ttgacgattg aagatggctc ttatacagct ttaattgggc
      481 acacaggtag tggtaaatca actattttac aactcttaaa tggtttattg gtgccaagtc
      541 aagggagtgt gagggttttt gataccttaa tcacctcgac ttctaaaaat aaagatattc
      601 gtcaaattag aaaacaggtt ggcttggtat ttcagtttgc tgaaaatcag atttttgaag
      661 aaacggtttt gaaggacgtt gcttttggac cgcaaaattt tggagtttct gaagaagatg
      721 ctgtgaagac tgcgcgtgag aaactggctc tggttggaat tgatgaatca ctttttgatc
      781 gtagtccgtt tgagctgtca gggggacaaa tgagacgtgt tgccattgca ggcatacttg
      841 ccatggagcc agctatatta gtcttagatg agccaacagc tggtctagat cctctaggga
      901 gaaaagagtt gatgaccctg ttcaaaaaac tccaccagtc agggatgacc atcgtcttgg
      961 taacgcattt gatggatgat gttgctgaat atgcaaatca agtctatgta atggaaaagg
     1021 gacgtttagt aaaggggggc aaaccaagtg atgtctttca agacgttgtt tttatggaag
     1081 aagttcagtt gggagtacct aaaattacgg ccttttgtaa acgattggct gatagaggcg
     1141 tgtcatttaa acgattaccg attaagatag aggagttcaa ggagtcgcta aatggatagt
     1201 atgattttgg ggcgttatat cccaggggat tcgattgttc accgattgga tccacgtagc
     1261 aaattgcttg ctatgatgct actgattttg attgtgtttt gggctaataa ccccttgacg
     1321 aatctgattc tttttatagc gacagggata tttattgcct tgtcaggagt atctctttca
     1381 ttttttattc agggcttgaa gtctatgttt ttcttgattg ccttcacaac tatttttcaa
     1441 ctatttttca tttctaatgg gaatgtttta tttgagtttt cgtttgtgag aatcacggat
     1501 tatgctttgc aacaagctgg gattattttt tgtcgctttg tattgattat tttcttttca
     1561 actttgttaa ccttaacaac catgccttta agtttggcat cagctgtcga agctttatta
     1621 gcacctttaa agcgtgtgaa agttccagtt catgaaattg gattgatgct gtctatgagt
     1681 ttgcgttttg tcccaacctt gatggatgat acgactcgga ttatgaatgc acagaaagct
     1741 cgtggagtgg attttggaga aggaagcatc gttcaaaaag taaaggcgat gattcccatt
     1801 ttgattcctc tttttgcgac aagtttaaaa cgtgcagatt ccttggctat cgctatggaa
     1861 gcgcgtggct atcagggtgg aaaaggcaga agtcaatacc gacaattgaa atggactcta
     1921 aaggatacgc tgaccattct tgttattctc gtacttggtt gttgtttatt tttcttaaaa
     1981 tcttagtagc tttcaggaat tgataaaaag ttactgtaac agtttttgat ataaaggtag
     2041 ggatatgaac cgttttaaaa aatcaaaata tgtcattatt gtttttgtca ctgttctgct
     2101 tgtgtcagct ctcttagcga cgacttattc aagtacaatt gtgacaaaat taggagatgg
     2161 aatctcattg gttgatagag ttgtacaaaa accttttcag tggtttgatt ctgtcaaatc
     2221 agatttggct catttgacac gaacatataa tgaaaatgaa agtttgaaga aacagcttta
     2281 ccaattagaa gttaaatcaa atgaggtgga aagtttaaag acagaaaatg aacaactgcg
     2341 ccaattgctt gatatgaagt ctaaattgca agccacaaag actttagcag cagatgttat
     2401 tatgcgttct ccggtatctt ggaagcagga gttgacctta gatgcaggta gatcaaaagg
     2461 tgcttctgag aacatgttag ctattgcaaa tggtggcttg attgggagtg tttcaaaagt
     2521 agaggagaac tctactatag tcaaccttct gacaaatacg gaaaatgctg ataagatttc
     2581 tgttaaaatt caacatggct ctactacaat ttatggaatt attattggct atgacaagga
     2641 aaatgacgtt cttaaaatta gccaattaaa tagtaatagc gatattagtg cgggagataa
     2701 ggtgactact ggtggattag gaaactttaa cgttgctgat attcctgttg gtgaagtggt
     2761 tgccacaacg catagtacag actatttgac acgagaagta actgttaaat tgagtgcaga
     2821 tactcataat gtagatgtga tagaattagt ggggaattca taatgagaca gttgaagcga
     2881 gttggagtat ttttattgct tcctttcttt gttctaattg acgcccatat tagccagctt
     2941 ctgggctcat ttttccccca tgtacatttg gctagtcatt ttctttttct atttctctta
     3001 tttgagacga tagaagtatc agagtatctc tacctagtct attgttttgt tataggcttg
     3061 gtttatgatg tttacttttt ccatctaata gggattacaa ctctcttatt tatcttattg
     3121 ggagccttcc ttcataaatt gaatagtgtt attttgttga atcgttggac aagaatgcta
     3181 gctatgattg tgctgacatt cctgtttgaa atgggtagtt atcttttggc ttttatggta
     3241 gggttgacag tagatagcat gtcgattttt atagtctata gcttggtacc gacgatgatt
     3301 ttaaattttt tatggattac tgtttttcaa tttatttttg aaaaatatta tctataagaa
     3361 cgacatataa atgtaacaaa ggcgtaatat ttattaggcc tttttttggt atactagtat
     3421 tgtctttaaa agaaggagta tctacgtaat atgaagaaaa aaatcttagc gtcactttta
     3481 ttaagtacag taatggtttc tcaagtagct gttttaacaa ctgcgcatgc agaaacgact
     3541 gatgacaaaa ttgctgctca agataataaa attagtaact taacagcaca acaacaagaa
     3601 gcccaaaaac aagttgacca aattcaggag caagtatcag ctattcaagc tgagcagtct
     3661 aacttgcaag ctgaaaatga tagattacaa gcagaatcta agaaactcga gggtgagatt
     3721 acagaacttt ctaaaaacat tgtttctcgt aaccaatcgt tggaaaaaca agctcgtagt
     3781 gctcaaacaa atggagccgt aactagctat atcaatacca ttgtaaactc aaaatcaatt
     3841 acagaagcta tttcacgtgt tgctgcaatg agtgaaatcg tatctgcaaa caacaaaatg
     3901 ttagaacaac aaaaggcaga taaaaaagct atttctgaaa aacaagtagc aaataatgat
     3961 gctatcaata ctgtaattgc taatcaacaa aaattggctg atgatgctca agcattgact
     4021 acgaaacagg cagaactaaa agctgctgaa ttaagtcttg ctgctgagaa agcgacagct
     4081 gaaggggaaa aagcaagtct attagagcaa aaagcagcag ctgaggcaga ggctcgtgca
     4141 gctgcggtag cagaagcagc ttataaagaa aaacgagcta gccaacaaca atcagtactt
     4201 gcttcagcaa acactaactt aacagctcaa gtgcaagcag tatctgaatc tgcagcagca
     4261 cctgtccgtg caaaagttcg tccaacatac agtacaaacg cttcaagtta tccaattgga
     4321 gaatgtacat ggggagtaaa aacattggca ccttgggctg gagactactg gggtaatgga
     4381 gcacagtggg ctacaagtgc agcagcagca ggtttccgta caggttcaac acctcaagtt
     4441 ggagcaattg catgttggaa tgatggtgga tatggtcacg tagcggttgt tacagctgtt
     4501 gaatcaacaa cacgtatcca agtatcagaa tcaaattatg caggtaatcg tacaattgga
     4561 aatcaccgtg gatggttcaa tccaacaaca acttctgaag gttttgttac atatatttat
     4621 gcagattaat ttacagaggg actcgaatag agccctcttt tcaggtttta ccgtgacaat
     4681 ccctattaaa aattatatca aaatagcttg aaaatattgg aaaagtatgg tagaatgaaa
     4741 attgtcgtgt gaacgataat actcattctt gatgaattgt gaagcagttg cccttgggtc
     4801 gttttgcgag ttgaagtcaa gaagaggaaa aaaacaaaaa ggagaaatac tcatggcagt
     4861 aatttcaatg aaacaacttc ttgaggctgg tgtacacttt ggtcaccaaa ctcgtcgctg
     4921 gaatcctaag atggctaagt acatctttac tgaacgtaac ggaatccacg ttatcgactt
     4981 gcaacaaact gtaaaatacg ctgaccaagc atacgacttc atgcgtgatg cagcagctaa
     5041 cgatgcagtt gtattgttcg ttggtactaa gaaacaagca gctgatgcag ttgctgaaga
     5101 agcagtacgt tcaggtcaat acttcatcaa ccaccgttgg ttgggtggaa ctcttacaaa
     5161 ctggggaaca atccaaaaac gtatcgctcg tttgaaagaa attaaacgta tggaagaaga
     5221 tggaactttc gaagttcttc ctaagaaaga agttgcactt cttaacaaac aacgtgc
//
LOCUS       DBMVGT010000094         5246 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.094, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000094 DBMVGT010000000
VERSION     DBMVGT010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5246)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5246)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5246
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.094"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..379
                     /locus_tag="AC0DU4_001940"
     CDS             <1..379
                     /locus_tag="AC0DU4_001940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="U32 family peptidase C-terminal
                     domain-containing protein"
                     /protein_id="HIN4237849.1"
                     /translation="TGFYYGTPSENEQLFGARRKIPEYKFVAEVVSYDDATQTATIRQ
                     RNVINEGDQVEFYGPGFRHFETYIEDLHDAKGNKIDRAPNPMELLTIKVPQPVQAGDM
                     VRALKEGLINLYKEDGTSVTVRA"
     gene            769..1605
                     /locus_tag="AC0DU4_001941"
     CDS             769..1605
                     /locus_tag="AC0DU4_001941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000452046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237850.1"
                     /translation="MNVSKHYGHSIILKDINFALNKGEIVGQVGRNGVGKSTLMKILV
                     QNNQPTSGNIISSDNVGYLIEEPKLFLSKTGLENLKYLSNLYGVDYNQERFRSLIQEL
                     DLTQSINKKVKTYSLGTKQKLALLLTLVTEPDILILDEPTNGLDIESSQIVLSVLKNL
                     ALHENVGILISSHKLEDIEEICERVLFLENGLLTFQKVGKDSHNFLFEIAFSSATDRD
                     IFITKQEFGDIVQEEGLRITMSGNIQSSELFKFFNENSIKVVDFETKKEMLKDIYLNR
                     SK"
     gene            1621..2349
                     /locus_tag="AC0DU4_001942"
     CDS             1621..2349
                     /locus_tag="AC0DU4_001942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237851.1"
                     /translation="MKLNKFNFIKENIRDLYSSGVIYLGLIISFIPPILLTFFILKTQ
                     GTSLGIKHISNFYAMLGMLMAVIHANRIISRDFSHNTISLFYNQQKNRMIYLLSNFLY
                     AISVSIIYALNGIVLLVIVSKLGIPGDLGLDFIVAIVVNTILLVLFYFLLSYIFYLYK
                     LKSGLVFGILVALLLFIPNILNTMMMNTSNDLFIKAIELLPFYSLPVFVTSNTMSISQ
                     YLVVITTIILLYFFTLKKSKKYSF"
     gene            2735..2944
                     /locus_tag="AC0DU4_001943"
     CDS             2735..2944
                     /locus_tag="AC0DU4_001943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HIN4237852.1"
                     /translation="MAKNLKLKLARVERDLTQGQLAEAVGVTRQTIGLIEAGKYNPSL
                     SLCQSICRCLGKTLDQLFWEEEDEK"
     gene            2934..3422
                     /locus_tag="AC0DU4_001944"
     CDS             2934..3422
                     /locus_tag="AC0DU4_001944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000797183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6773 family protein"
                     /protein_id="HIN4237853.1"
                     /translation="MKNRFYYYQLLDEREEQLFNKAGSESFYICIALSLLSYIISVLA
                     PSLFNSNMLLIVIIIGTFYFFNRARYLGVTYYSRFHFTILGCFFLTLAITALLMLQNY
                     QFNIEIYQHNPLNFKYLSAWVITYVIYLPWVFIGNLGLKSYGEWAQKKFEQDMDELES
                     GE"
     gene            3538..4998
                     /locus_tag="AC0DU4_001945"
     CDS             3538..4998
                     /locus_tag="AC0DU4_001945"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004516 - nicotinate
                     phosphoribosyltransferase activity [Evidence IEA];
                     GO_process: GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HIN4237854.1"
                     /translation="MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFK
                     NGYAVFAGLERIVNYLEDLRFSDSDIAYLESLGYHGAFLDYLRNFKLELTVRSAQEGD
                     LVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRR
                     AQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYA
                     ATHKNCVFLVDTYDTLRIGVPAAIQVARELGDQINFMGVRIDSGDIAYISKKVRQQLD
                     EAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALGAVYKIVAIE
                     DETGQMRNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISYMTEIKM
                     FHPTYTYIKKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRV
                     LNPQHYPVDLARDVWQDKMDLIDKMRKEALGEGEEE"
     gene            4995..>5246
                     /locus_tag="AC0DU4_001946"
     CDS             4995..>5246
                     /locus_tag="AC0DU4_001946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ammonia-dependent NAD(+) synthetase"
                     /protein_id="HIN4237855.1"
                     /translation="MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFV
                     LGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLP"
BASE COUNT         1659 a          826 c         1076 g         1685 t
ORIGIN      
        1 tacaggattt tactatggta caccatctga aaatgagcag ttgtttggtg ctcgtcgtaa
       61 aattcctgag tacaagtttg tcgctgaagt ggtttcttat gatgatgcga cacaaacagc
      121 aaccattcgt caacggaacg tcattaacga aggggaccaa gttgagtttt atggtccagg
      181 tttccgtcat tttgaaacct atattgaaga tttgcatgat gccaaaggaa ataaaatcga
      241 ccgcgctcca aatccaatgg aactattgac tattaaagtc ccacaacctg ttcaagctgg
      301 agacatggtt cgagctctta aagaggggct tatcaatctt tataaggaag atggaaccag
      361 cgtcacagtt cgtgcttaat gtagttgttt agttttaaaa aattatgcaa agctccatat
      421 acaacactta aacgagatta aagaatggcg aaatcccctg atgcgcaaga gattagctgt
      481 cttttttatt ttttaagtga taaagtcgga gcttaggtat caaagcctat caaattaaac
      541 aaagaagcga tgtcttagat attttgaaaa aaattaataa gcagaaaact ctctattatt
      601 ttgttgtata gagttttttg ttaataaaat ttcacaaaat gacatttata tattgcatta
      661 agttagatat atgatataat attgttaaaa agaggcgcaa ctttttaaaa ttaatgagaa
      721 tcaaagagaa aaccaataat attaatggag gaataaaaaa tgtaagttat aaatgtaagt
      781 aagcattatg gtcattcaat cattctcaaa gacataaatt ttgcacttaa caagggtgaa
      841 attgttggtc aagtagggag aaatggagtt ggtaagagta cgttgatgaa aattcttgtt
      901 cagaataatc aaccgacttc aggtaatatt ataagcagtg ataatgttgg gtatttaatc
      961 gaagaaccaa aattattttt atctaaaaca ggtttagaga atttaaaata tttgtcaaat
     1021 ttatatggtg ttgactacaa tcaagaaaga tttagaagtt tgatccaaga gttagatttg
     1081 actcagtcta ttaataaaaa agtaaagacc tattctttgg gtacaaaaca aaaattagct
     1141 ttgcttctaa ctctcgttac ggaacctgat atattgattt tagatgaacc gactaatggt
     1201 ttagatattg aatcatcaca aatagtttta tcggttctaa aaaatttagc tttacatgaa
     1261 aatgtgggaa ttttaatatc gagtcataaa ttagaagata ttgaagaaat ttgtgagagg
     1321 gttcttttct tggagaacgg gcttttgaca tttcaaaaag taggaaaaga tagtcataat
     1381 ttcttgtttg agatagcttt ttcatcagct acagatagag acattttcat taccaaacaa
     1441 gaatttgggg atattgttca ggaagaggga ctgagaatta ctatgtctgg gaatattcaa
     1501 agtagtgagc tttttaaatt ttttaacgaa aactctatta aagtagttga ttttgaaact
     1561 aaaaaagaga tgcttaaaga tatttatcta aatcgttcaa aataaaggaa ggttataatc
     1621 atgaaattaa ataaatttaa ttttattaag gaaaatataa gggatttata ttcatcaggc
     1681 gtaatatatc tcggtttgat tatctcgttt ataccgccga tattgcttac attctttatt
     1741 ctaaagactc aagggacatc gcttggtatt aagcatattt caaactttta tgctatgctc
     1801 ggtatgttaa tggctgttat acatgctaac cgaattatta gcagggattt ttcccacaat
     1861 acgatcagtt tattttataa tcaacagaaa aatcggatga tttacctctt gtctaatttt
     1921 ctatatgcca tctcagtttc cattatttat gctttgaatg gcattgtgtt actagtcata
     1981 gtaagtaaat tgggtattcc aggtgattta ggattagatt ttatagtagc tattgtagtc
     2041 aatacaattt tgttagtcct gttttatttt ctattatctt acattttcta tttatacaaa
     2101 ttgaaaagtg gcttggtatt tggtatttta gtagctttac tactctttat ccctaatata
     2161 ttaaatacga tgatgatgaa tactagtaat gatttgttta tcaaagcaat tgaacttctt
     2221 cctttttatt ctttacctgt atttgtgact tcaaatacga tgtctattag tcagtatctt
     2281 gtggtaatca ctacaatcat tttattgtac tttttcactc tcaagaaaag caagaagtat
     2341 tcattttagt ttcatttagt attattttgc atacctaaaa tacaataaaa aaatcagtca
     2401 tcttggtatg ctcctgcttt cactattcaa cacgtttttg acttatacta ggctcatttc
     2461 caaaagcatt atataatagt gatatgaaac caactaaact aaacaagaaa tataagcaat
     2521 aaaaactcgt ttaaaagatt ctactaaagc taatactaaa taaaaataaa agagtaaact
     2581 aggaagttta tttcaaacaa cctaaaatac tgattttcgg ctgaagataa tactggagtg
     2641 caaattaatg gggttataat aaatagctga tagcttgtgt tggttttgga ttttttaaga
     2701 gtagatgagt attaaaacta taaggaggac gaaggtggct aaaaatttaa aattaaaatt
     2761 agctcgggta gagcgtgatt taacacaagg tcaactggca gaggctgtcg gggtgacacg
     2821 ccagactatt ggtttgatag aggcgggaaa atacaatccc agtctctcgc tctgccagtc
     2881 tatttgcaga tgtttaggga aaaccctaga ccaactattt tgggaggaag aagatgaaaa
     2941 atagatttta ttattatcaa ttactagacg aaagagaaga acaactgttc aataaagcgg
     3001 gctctgaaag tttctatatc tgcattgctt tgtcgctcct atcttatatc atttcagtat
     3061 tagcaccaag cctttttaat tctaatatgc tgctaatcgt tatcatcata gggacatttt
     3121 actttttcaa tcgtgcccgt tatctgggag tgacctacta tagtcgtttt cattttacga
     3181 ttttgggttg ttttttccta accttggcta ttacggctct tttgatgttg cagaattatc
     3241 aattcaacat agaaatttat cagcacaatc ctttgaattt taaatacctg tctgcttggg
     3301 tcattactta tgtcatttac cttccgtggg tctttattgg caatcttggt cttaagagct
     3361 atggcgaatg ggctcagaaa aaatttgaac aagatatgga tgaattggag agtggagaat
     3421 agcttgttac tcttttctca atccagctaa aatgtgatat aatagtatta atttattgga
     3481 atacatgaaa gttcttgaaa attttcatgg gtttctagct aaggaagtag gaaaagtatg
     3541 tatccagatg atagtttgac attgcacacg gacttgtacc agatcaacat gatgcaggtt
     3601 tactttgacc aagggattca caataagaag gcggtctttg aggtgtattt ccgccaacag
     3661 ccttttaaga acggctatgc ggtttttgca ggtttggaaa gaattgtgaa ctatcttgaa
     3721 gacttgcgtt tttcagatag tgatatagcc tatttggagt cgcttggtta tcatggggcg
     3781 ttcttggatt accttcgcaa tttcaagttg gagttgaccg ttcgttctgc ccaagaaggg
     3841 gatttggttt ttgctaatga accgattgtg caggtggaag gacctctagc ccaatgtcag
     3901 ttggtcgaaa cggctctttt gaacatcgtc aactaccaga ccttggtggc gacgaaggca
     3961 gctcgtattc gttcggttat cgaagatgaa cccttgatgg agtttgggac acgtcgggct
     4021 caagaaatgg atgcggccat ctggggaaca cgcgcagctg tgattggtgg cgccaatgga
     4081 accagcaacg tgcgtgcggg taagctcttt gacattcctg ttttgggaac ccatgcccat
     4141 gccttggtac aggtttatgg aaatgactat gaagctttca aggcttacgc tgcgacccac
     4201 aaaaattgtg tctttcttgt ggatacctat gacacccttc gcatcggtgt accagctgcc
     4261 attcaggtgg cgcgtgagct gggtgatcag attaacttta tgggtgtgcg gattgactct
     4321 ggggatattg cctacatttc taagaaagtc cgtcagcaac tggacgaggc tggatttaca
     4381 gaggctaaga tttatgcttc taatgatttg gacgaaaata ctatcctcaa cctcaagatg
     4441 caaaaggcca agattgatgt ctggggcgtg ggtaccaagc tgattacagc atatgaccag
     4501 ccagctcttg gggcggttta caagattgtt gcaatcgaag atgaaactgg tcagatgcgc
     4561 aatacgatta agctgtctaa taatgctgaa aaagtctcta cgccaggtaa gaagcaggtg
     4621 tggcgcatta ccagtcgtga aaaaggtaag tcagaaggtg actacatcac ttatgatggt
     4681 gtggatatta gctacatgac agaaatcaag atgttccatc cgacctatac atacatcaag
     4741 aagacggttc gtaattttga tgccgttcct ctcttggtgg atatcttcaa agaaggaata
     4801 ttagtttaca acttgcctag tttgactgac attcaggatt atgcccgtaa agaatttgac
     4861 aagttgtggg atgagtataa gcgtgtgctc aatccgcagc actatccagt ggatttggcg
     4921 cgtgatgtat ggcaagataa gatggacttg attgataaga tgcgcaagga agcccttggt
     4981 gaaggagaag aagaatgagt ttgcaagaaa cgattatcca agagctgggt gtcaaaccag
     5041 tgattgatgc ccaggaagaa atccgtcgtt ctattgattt cttaaaaaga tatctgaaaa
     5101 aacatccctt cctaaaaacc tttgtactag ggatttctgg gggacaagac tcaaccttgg
     5161 cagggcgttt ggcgcaatta gctatggaag aactgcgagc tgaaacggga gacgacagct
     5221 acaaatttat cgctgtccgc ctgcca
//
LOCUS       DBMVGT010000095         5011 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.095, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000095 DBMVGT010000000
VERSION     DBMVGT010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 5011)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5011)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5011
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.095"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(155..775)
                     /locus_tag="AC0DU4_001947"
     CDS             complement(155..775)
                     /locus_tag="AC0DU4_001947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001172828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HIN4237856.1"
                     /translation="MQKTAFIWDLDGTLLDSYEAILSGIEETFAQFSIPYDKEKVREF
                     IFKYSVQNLLVRVAEDRNLDVEVLNQVRAQSLAEKNAQVVLMPGAREVLAWADESGIQ
                     QFIYTHKGNNAFTILKDLGVESYFTEILTSQSGFVRKPSPEAATYLLDKYQLDPEKTY
                     YIGDRTLDVEFAKNSGIQSINFLESSFEGNHRIQALADISRIFETK"
     gene            complement(779..2059)
                     /locus_tag="AC0DU4_001948"
     CDS             complement(779..2059)
                     /locus_tag="AC0DU4_001948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HIN4237857.1"
                     /translation="MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGV
                     SVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFL
                     SIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYV
                     SFLSNALNILFSSLAIFVLDMGIAGVAWGTILSRLVGLVILWSQLKLPYGKPTFGLDK
                     ELLTLALPAAGERLMMRAGDVVIIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATA
                     TVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVE
                     ASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLMGIVL
                     GWGLPGIWAGSLLDNGFRWLFLRYRYQRYMSLKG"
     gene            complement(2120..3604)
                     /gene="thrC"
                     /locus_tag="AC0DU4_001949"
     CDS             complement(2120..3604)
                     /gene="thrC"
                     /locus_tag="AC0DU4_001949"
                     /EC_number="4.2.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004795 - threonine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HIN4237858.1"
                     /translation="MTLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLDF
                     DKLKDASYQEVAKLVLSAFLDDFTAEELDYCINNAYDSKFDTPAIAPLVKLDGQYNLE
                     LFHGSTIAFKDMALSILPYFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFADVPGT
                     EIIVFYPKDGVSKIQELQMTTQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTT
                     NKLQFSSANSMNIGRLVPQIVYYVYAYAQLVKTGETVAGEKVNFTVPTGNFGNILAAF
                     YAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPSMDILVSSNLERLIF
                     HLLGNNAEKTAELMNALNMQGQYKLTDFDAEILDLFAAEYATEEETAAEIKRVYELDS
                     YIEDPHTAVASAVYRKYQAVTDDATKTVIASTASPYKFPVVAVEAVTGKAGLTDFEAL
                     AQLHEISGVAVPPAVDGLETAPVRHKTTVAAADMQVAVEAYLGL"
     gene            complement(3680..4957)
                     /locus_tag="AC0DU4_001950"
     CDS             complement(3680..4957)
                     /locus_tag="AC0DU4_001950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamylcysteine synthetase"
                     /protein_id="HIN4237859.1"
                     /translation="MSCSIDLLKHRYLKNIKENPELFVGIELEYPVASLEGDATDVEV
                     IKDLFHYLVSTLDLTVAKIDDFGNLIQLVDPISQDAILFEVSYTTIEFAFGKAETIQE
                     VENRFNNYMNVIQRKLAESNHAIVGCGIHPNWDKNENCPVAYPRYQMLMDYLNLSRNI
                     IKSDLHHFPEYGTFICGSQVQLDISKTNYLRVINAFTQIEAAKAYLFANSEFSGADWD
                     TKISRDIFWEESMHGIYPENVGVNARLLNDEADFFDYLNHSAIFTAERDGQTYYFYPI
                     QAGDYLATPEIQAFSLNGDEVIIYPQEKDFETHRSYQYQDLTTRGTVEFRSVCTQPLD
                     RTFASAAFHLGLLVNLDKLEAYLETAPFFKVFGYDYKSLRRQFSKKNLTDEEETTIIE
                     FSKDLLLLAEEGLVVRNKEEMTYLQPLREELSL"
BASE COUNT         1594 a         1191 c          825 g         1401 t
ORIGIN      
        1 cctttcaaat gagtacctgt ctatcataac acaaaaaatg tagaaaaaaa gccctctcgg
       61 gcctatttaa cagaactgtc tattccttgt aacaaactag attacttgaa atagtttgtt
      121 aggtctctgt cacaaaactg acacaatctt tttatcactt agtctcaaaa atacgggaaa
      181 tatctgctag tgcttgaatc ctgtgattgc cttcaaaaga agattctaaa aagttgatgc
      241 tttgaatacc gctattcttg gcaaattcca catctaaagt ccggtcccct atataatagg
      301 tcttctcagg atccagctga tacttatcta gcagataggt agccgcttct ggacttggct
      361 tccgcacaaa gccactctga ctggttaaaa tctctgtaaa ataggattcc acccccaagt
      421 ccttgagaat ggtaaaagcg ttgttcccct tatgagtata tataaactgc tgaattcctg
      481 attcgtctgc ccaagctagc acctcacgcg cacctggcat caaaactacc tgagcattct
      541 tctcagccag actctgggca cgcacctgat ttagcacctc aacatccaga tttctatctt
      601 ctgccacccg cacaagcaaa ttttgcaccg aatacttgaa gataaactct ctcaccttct
      661 ccttatcata aggaatagaa aactgagcaa aagtctcctc aatccctgat aaaatcgctt
      721 cgtaagagtc caataaagtc ccgtctaaat cccaaataaa agctgttttt tgcatttcct
      781 atcctttcaa gctcatatag cgctggtaac gatagcgtag aaataaccag cgaaaaccat
      841 tatccaagag agaccctgcc caaataccag gcaagcccca accaagcaca atccccatca
      901 gatatcctgt cccaatgcgg atacaccaca tgcctatact tgtcgcataa aaagggaggc
      961 gtgcatttcc taatccctgc cagactgccg tatagatgac tgttcctgtc gtcatagggg
     1021 tcccaagtag tgaaaacagt gtcactagaa cactagcctc caccgctaga gaatcagtcg
     1081 tatagagatg agttaatggt acacccaaga catatatact aaaggacagg ggcaacatga
     1141 ggaacagaga aagccaaaag gtttgtttac tcaaactagc aactcttttc caatcatcct
     1201 ctccaactgc tcgggccaac agcatgaccg ttgccgtagc gacaccaaag gcaggcatat
     1261 agttaaactg ggtcaagact tctccgattg cattcccagc aactgcctcc gtcccaaaag
     1321 aaacgaccaa ggcaatgatc actacatctc cagccctcat cataagtcgc tctccagctg
     1381 ctggtaaagc caaggtcaac agttccttat ctaaaccaaa agttggcttc ccataaggca
     1441 gttttaattg tgaccacaaa atcacaagac caaccaaacg agacagaatt gtcccccaag
     1501 caacaccagc tatccccata tccagaacaa aaatagctag acttgaaaaa agaatattca
     1561 aggcattgga taaaaaacta acatagagag gcagacgtgg attatgcgtt gcacgaatca
     1621 aggctcccag actagtcatt aaacctaaga gaacaatcga tccgcctacc aaagatagat
     1681 acagtccacc actctcagct acatccctct ccgtccccaa aagtcctatc atctctttcc
     1741 cagcgaagat ggacaaaaat cctaaaagga aacttaatag taaggtaatc ttcaacgcct
     1801 cagtcacatg ataggccaac ttcgactggt ctttctgccc tatgcttttt gaaataacac
     1861 tggaaatagc agctcccaga gcgatgaaaa tcgcctgata aatggtgata atattaccag
     1921 ctaccgaaac ccctgaaata gctatcaatc ctaaatgagc aaccaaataa ctgtccacca
     1981 ttcccattag catctgcaaa aagttttcac ccatagctgg caatgcaata ttaagaatgt
     2041 ctttattttt cttaaacaat ctctcctcct gatgaaaaga aactcagttg gtttcccaac
     2101 cgagtttact ccctctatct taaagtccta aataagcctc aaccgctact tgcatgtcag
     2161 cagctgccac tgttgtcttg tgacgaacag gagctgtctc aagcccatca actgctggtg
     2221 gcactgcaac gcctgagatt tcatgtaatt gagccaaagc ttcaaagtct gttaaacctg
     2281 cttttccagt tacagcttct actgcaacta ctgggaactt gtagggacta gctgttgaag
     2341 caatcactgt cttagtcgca tcatcagtaa ccgcttggta ttttctataa actgctgagg
     2401 caaccgccgt atgtggatcc tcaatataag aatctaactc ataaacacgc ttgatttctg
     2461 ccgctgtttc ttcctcagtc gcatattcag ctgcaaagag gtccaaaatc tctgcatcaa
     2521 agtctgtcaa cttatattgt ccttgcatgt tcaaagcatt catgagttca gctgtctttt
     2581 cagcattatt tcccaaaaga tggaaaatca agcgctccaa gtttgaagat accaagatat
     2641 ccatagatgg gctggttgtt accttaaact cacgtttttt gtcatagaca cgtgttttaa
     2701 agaagtctgt caaaacattg ttgtcatttg aagcacagat caatttacca actggcaaac
     2761 caatttgttt ggcataaaag gcagccaaga tatttccaaa gtttcctgtt ggtactgtga
     2821 agttaacctt ttcaccagct acagtttcac cagtcttaac caattgagcg taagcataaa
     2881 cataataaac aatttgtggc accagacgac caatgttcat agagttagct gatgaaaatt
     2941 gcaacttgtt ggtagtcaat ttttcacgaa gagccacatc gttaaacatg tgcttcacat
     3001 ttgtttgcgc atcgtcaaag ttaccatcaa tagcaataac atgagtattg tcgccagtct
     3061 gagtggtcat ttgtaactct tgaatcttgc tgacaccatc ctttggataa aagacgataa
     3121 tctcagtacc aggcacatcc gcaaaccccg ccatagcagc tttccccgtg tcaccagatg
     3181 tcgctgtcaa gataacaatc ttgttctcca aaccatgttt cttagcagca gtcgtcataa
     3241 agtatggcaa aatagacaag gccatatcct taaaggcaat cgttgaacca tggaaaagtt
     3301 ccaaattgta ttgcccatct aatttcacta atggtgcaat agctggagta tcaaatttgc
     3361 tatcgtaggc attgttgata cagtagtcca actcctcagc tgtaaagtca tctaaaaatg
     3421 ctgacaaaac tagcttagca acttcctggt aagaagcatc tttcaatttg tcaaagtcca
     3481 aatctacctt tggataagta accggtgtaa acaaaccgcc gtccgtcgcc aaaccttgca
     3541 aaattgcttg actggcagtt actgtattgt tggcatcacg cgttgattga taaactaatg
     3601 tcattactct ctatccttta tctatagtct cgtccattat atcatgattt ttcagaaaat
     3661 tctcccttta taagagaaat tataggctca attcttctct caaaggctgt aaataggtca
     3721 tttcttcctt atttctcacc actagtccct cctcagctag taggagtaag tctttggaaa
     3781 attcaataat cgtagtttct tcctcatctg taagattttt cttagaaaat tgtctcctta
     3841 aagacttgta atcataacca aatactttaa agaaaggtgc tgtttctaag taagcttcta
     3901 acttgtctaa attaaccaat aatcccaagt gaaaagctgc agaagcaaaa gttctatcaa
     3961 gtggctgtgt acacacacta cgaaactcaa ctgttcctcg agtcgttaag tcttggtact
     4021 ggtaactacg atgagtttca aaatccttct cttgggggta aataataacc tcatccccat
     4081 tcagagaaaa tgcttggatt tcaggcgtag ccaaatagtc cccagcctga ataggataaa
     4141 aataataggt ctgcccatca cgttccgcag taaaaatcgc agaatgattt agatagtcaa
     4201 aaaaatcagc ttcatcatta aggagtctag cattgacccc aacattctct ggatagatac
     4261 catgcataga ttcttcccag aaaatatccc ttgaaatttt cgtatcccaa tccgcacccg
     4321 aaaactcaga gtttgcaaat aaataagcct tagccgcttc aatttgagta aaagcattaa
     4381 tcacccgtaa gtagttggtt tttgaaatat ccagctgaac ctggctccca cagataaaag
     4441 taccatattc agggaaatga tgtaaatctg atttaataat atttctactc aaattcaaat
     4501 aatccatcaa catctgatag cgtggataag ccactggaca attctcattt ttatcccagt
     4561 tgggatggat accacagcca acaatagcat gatttgattc agctaacttt ctctgaatta
     4621 cattcatata attattgaaa cgattttcga cctcttgaat cgtttcagcc ttaccaaatg
     4681 caaactcaat cgttgtatag gaaacttcaa ataaaatagc atcctgactt atcggatcta
     4741 ctaactggat cagattgcca aaatcatcta tctttgctac ggtgagatcc aaagtagaaa
     4801 ctaaataatg aaatagatcc tttataactt caacatctgt agcatcccct tctaaacttg
     4861 caacaggata ctccaactca attccgacaa acaattcagg attttcttta atatttttca
     4921 aataccgatg ttttaataaa tcgatagaac aagacatact cccctacact ttcttaatct
     4981 aaataaaatt tgaataacta taattatacc a
//
LOCUS       DBMVGT010000096         4979 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.096, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000096 DBMVGT010000000
VERSION     DBMVGT010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4979)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4979)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4979
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.096"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..707)
                     /locus_tag="AC0DU4_001951"
     CDS             complement(<1..707)
                     /locus_tag="AC0DU4_001951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HIN4237860.1"
                     /translation="MENVVVHIISHSHWDREWYLPFESHRMQLVELFDNLFDLFENDP
                     EFKSFHLDGQTIVLDDYLQIRPENRDKVQRYIDEGKLKIGPFYILQDDYLISSEANVR
                     NTLIGQQEAAKWGKSTQIGYFPDTFGNMGQAPQILQKSGIHVAAFGRGVKPIGFDNQV
                     LEDEQFTSQFSEMYWQGVDGSRVLGILFANWYSNGNEIPVDKDEALTFWKQKLSDVRA
                     YASTNQWLMMNGCDHQPV"
     gene            complement(798..2078)
                     /locus_tag="AC0DU4_001952"
     CDS             complement(798..2078)
                     /locus_tag="AC0DU4_001952"
                     /EC_number="3.2.1.163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004559 - alpha-mannosidase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 125 protein"
                     /protein_id="HIN4237861.1"
                     /translation="MIYSKEIVREWLDEVAERAKDHPEWVDVFERCYTDTLDNTVEIL
                     EDGSTFVLTGDIPAMWLRDSTAQLRPYLHVAKRDALLRQTIAGLVKRQMTLVLKDPYA
                     NSFNIEKNWKGHHETDHTDLNGWIWERKYEVDSLCYPLQLAYLLWKETGETGQFDETF
                     VAATKEILHLWTVEQDHKNSPYRFVRDTDRKEDTLVNDGFGPDFAVTGMTWSAFRPSD
                     DCCQYSYLIPSNMFAVVVLGYVQEIFVELDLADSQSVIADAKRLQDEIQEGIENYAYT
                     TNSKGEKIYAFEVDGLGNASIMDDPNVPSLLAAPYLGYCSIDDEVYQATRRTILSSEN
                     PYFYQGEYASGLGSSHTFYRYIWPIALSIQGLTTRDKAEKKFLLDQLVACDGGTGVMH
                     ESFHVDDPTLYSREWFSWANMMFCELVLDYLDIR"
     gene            2249..4333
                     /locus_tag="AC0DU4_001953"
     CDS             2249..4333
                     /locus_tag="AC0DU4_001953"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000803403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GH92 family glycosyl hydrolase"
                     /protein_id="HIN4237862.1"
                     /translation="MKPLLETIDTRLGTTNKHAFSRGNTLPYTGVPFGMNYFVPQTSD
                     QDGSWFFDPHLPIFQGIRLTHQPSPWIGDYSWLLLTPVTGQLGGDSLFHRQSSYDRDK
                     ASFQPHYLKIFSLRYQIETQLTPTCYGASIRLKQKQGKALSLYLHAADELTVEQVDKR
                     TLALRQEGKTETNKNSLTMFTALQMNTDILAISQEAGDWRIDLASSQTEMQLATSFIS
                     PSQALINLPQEDFDSCKASAQADWENLLHRFDVIETGEANRTFFDHCLYRLFLFPQTF
                     YEVDESGQAIHMDLATGTVKPGVLFSNNGFWDTFRTTFPLFALIIPEHYQRFLEGFLN
                     SYRDTGFLPKWLAPDERGMMPGTLLDGIIADSACKDMAPDLEGELFQAMLKTASKADP
                     LGINGRHGLAQYQELGYLSTDHHESVSHTLDYAYSDFCIANCAKKLKNIEIAETYKAA
                     SQNYRQLFDAETGYMRARDNQGNFHPDFSPYSWGRDYAECSAIQATLGVLHDIPGLIQ
                     LMGGKETFSNYLLKACQDAPLFETTGYGYEIHEMSEMATAPFGQIAISNQPSFHIPYL
                     FRYSDYPDYTALLIKTLRQKAFHPSWEAYPGDEDNGSLSAWYIWSALGFYPTCPGKPS
                     YDLGIPLFDHLRVYLAKENKWLDIHTEQNHSHFNFVKECRLDKTLVSTIQHQDLLKAE
                     QLTFTLSWLPNH"
     gene            complement(4373..>4979)
                     /locus_tag="AC0DU4_001954"
     CDS             complement(4373..>4979)
                     /locus_tag="AC0DU4_001954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HIN4237863.1"
                     /translation="DADLPIQLELDLGSPKTFDVIELREDLKLGQRISAFHVQVEVDG
                     VWQEFGRGFTVGHKRLLRGAVVEAQKIRVVITESQALPLLTKISLYKTPRLSQTVAVQ
                     GLAFAEKSLAVAKGETLHFRIERSESSSSLEAKISIQPGTGVHGVAYQDEIQVLQFQA
                     GESKKDLHLPTLYFAGDKTLDFYLNLTVDGQLVDQLQVQVS"
BASE COUNT         1403 a         1253 c          987 g         1336 t
ORIGIN      
        1 acaggctggt ggtcacagcc gttcatcatc aaccattggt tggtcgaagc gtaggcacgc
       61 acatctgaca atttttgttt ccagaaggtc aaggcctcat ctttgtcaac tgggatttca
      121 ttcccattac tgtaccagtt ggcaaagaga atacctaaaa cacgactacc atccacaccc
      181 tgccagtaca tttctgaaaa ctgggatgta aactgctcat cttcaaggac ttggttgtca
      241 aatccaatcg gcttcacacc acgaccaaag gccgccacgt gaatgcctga tttttgaaga
      301 atttgaggcg cttgtcccat atttccaaag gtatctggaa agtagccaat ctgggttgat
      361 ttaccccatt tggcagcttc ttgttgacca atcaaggtat tgcggacatt ggcttcactg
      421 gagatcaagt agtcatcctg caagatgtaa aagggaccaa ttttaagttt gccctcgtca
      481 atgtagcgtt ggaccttgtc gcgattttca gggcgaattt gtaagtagtc atcaaggaca
      541 atagtttgtc catccaagtg gaaactcttg aactcagggt cattttcaaa gagatcaaag
      601 agattgtcaa acaattccac caactgcata cgatggcttt caaaaggcaa gtaccactca
      661 cggtcccagt gactatgtga gataatatgt acaacaacat tttccatgaa gtaaaacctc
      721 attctaaatt taaattttaa cgttttaaat gtaaacttgt gattctgata agaatcggtt
      781 gagctaaagc gagcccctta gcgaatatcc aagtaatcca agaccaactc acagaacatc
      841 atgttagccc aggagaacca ttcacgagag tagagggtcg gatcatctac gtggaagctt
      901 tcgtgcatga cacctgtacc accatcgcag gcaaccagct gatccagcaa gaattttttc
      961 tctgccttat ctcttgttgt caatccttgg atagaaaggg cgattggcca gatatagcga
     1021 tagaaggtat gagaacttcc gagaccgcta gcgtattctc cttggtagaa gtatggattt
     1081 tcagagctca gaatggtacg gcgagtggct tgatacactt catcatcgat cgaacagtag
     1141 cccagatagg gcgcagctag tagacttggt acatttggat catccatgat gctggcattt
     1201 cctaggccat ctacttcaaa agcgtaaatc ttttcgccct tgctgttggt ggtgtaagcg
     1261 tagttttcga ttccttcttg gatttcatcc tgaagacgct tggcatcagc aataacactc
     1321 tggctatcag ctaggtctaa ttcgacaaag atttcttgca cataacccaa gactactacg
     1381 gcaaacatat tagacggaat caagtaacta tactgacagc aatcgtcact cggacgaaaa
     1441 gctgaccaag tcatacctgt cactgcaaag tcaggtccaa agccatcatt taccaaggtg
     1501 tcttccttac ggtccgtatc tcggacaaaa cgataaggag agttcttgtg gtcttgttca
     1561 actgtccata gatggagaat ttccttagtc gctgcgacaa aagtctcatc aaactgacca
     1621 gtctcgccag tctctttcca gaggagataa gccaactgca aaggatagca aagtgaatcc
     1681 acctcatact tgcgctccca gatccagccg ttaaggtctg tgtggtcagt ctcgtggtgc
     1741 cctttccagt tcttctcaat gttgaaggag ttagcatagg gatccttgag taccaaggtc
     1801 atctgacgtt tgaccaaacc tgcaatggtc tgacgcagga gggcatctct tttagctaca
     1861 tgaaggtagg gtctgagttg ggctgtcgaa tctcgaagcc acatggcagg aatatcccca
     1921 gtcaagacaa aagttgaacc atcttctaag atttcaaccg tattgtccaa ggtatcggtg
     1981 tagcaacgct cgaaaacatc cacccactct ggatggtcct tagcccgctc tgctacttca
     2041 tctagccatt ctctaacaat ttctttcgaa taaatcatcg tgcaattccc tctttcaaac
     2101 aagtttcatt ttcagtatat agcttttgag acagaaaata catacacaaa tgatagtcat
     2161 ttttctacaa aatagttatc tttgaaactc cttttctaaa ggccctcttt ttctgatata
     2221 atgtagaaaa acagctaaag gaaagactat gaaaccacta cttgaaacca tcgatacccg
     2281 cttgggaact accaacaagc atgccttttc tcggggaaat accctgccat acacaggcgt
     2341 gccttttggg atgaattact ttgtgcccca gaccagtgac caggatggat cttggttctt
     2401 cgatccgcat ctgcctatct ttcaggggat tcgattaact caccagccca gtccttggat
     2461 tggggactac tcttggctcc ttctgacacc tgtcacaggt cagcttgggg gagacagtct
     2521 ctttcaccgc caatcttcct atgataggga taaggcctct ttccaacctc attatctaaa
     2581 gattttctcc ctgcgctatc aaattgaaac ccagctcaca ccgacttgct acggtgcttc
     2641 tattcgtttg aagcaaaagc aaggcaaagc cctctccctc tatcttcacg cagcagatga
     2701 actgacagta gagcaagtag ataagcgaac tcttgccctg cgacaagaag gtaaaactga
     2761 aaccaacaaa aattcgctaa cgatgttcac tgccctgcaa atgaacacgg atattcttgc
     2821 tatcagccaa gaagctggag actggcgaat tgacttagca agtagtcaaa ccgagatgca
     2881 actagccact tctttcatct ctccttctca agctctaatc aatctacctc aagaagattt
     2941 tgatagctgt aaagcaagtg cccaagcgga ttgggaaaat ctcctccatc gttttgatgt
     3001 tatagagaca ggagaggcta accgaacctt ctttgaccac tgtctctaca gactcttcct
     3061 cttcccacag actttttatg aggttgatga gtcagggcaa gccatccaca tggatctggc
     3121 tactggtact gtcaagcctg gtgtcctctt tagcaacaat ggtttctggg ataccttccg
     3181 caccaccttc cccctctttg cccttatcat accggagcac tatcaacgct ttttagaagg
     3241 tttcctcaat agctaccgcg atactggttt ccttccaaaa tggctggctc cagatgaacg
     3301 gggtatgatg ccaggtacac ttttagacgg tattatcgca gatagcgcct gcaaggacat
     3361 ggcccccgac ctagaaggag aactcttcca agccatgctc aaaacagcca gcaaagccga
     3421 ccctctcggc atcaatggcc gccacggact agcccaatac caagaactag gttacctctc
     3481 taccgaccac cacgaaagtg ttagccatac tctagactat gcctatagtg acttttgtat
     3541 cgccaactgt gccaaaaaac taaaaaacat agaaatcgct gaaacctaca aggctgcttc
     3601 acaaaattac cgccagctat ttgacgctga gacaggttac atgcgagcac gagacaatca
     3661 aggaaacttt caccctgact tctctcctta tagttggggg cgagactacg ctgaatgctc
     3721 tgccattcaa gctactttag gcgttctcca cgacatccct ggcttaatcc aactgatggg
     3781 tggaaaagaa acctttagca actatctttt gaaagcctgt caagatgctc ccctctttga
     3841 aacaacaggc tatggttacg aaattcacga aatgagcgag atggctactg ctccttttgg
     3901 acaaatagcc atttccaacc agcctagttt ccacattcct tatctcttcc gctacagcga
     3961 ttaccctgac tacactgccc ttcttatcaa gacgctccgt cagaaagctt ttcacccaag
     4021 ttgggaagcc tatcctggag atgaagacaa tggtagtctc tctgcttggt acatctggtc
     4081 agctctcgga ttttatccaa cctgtccagg aaaaccaagc tatgatctcg gaattcctct
     4141 ctttgaccat ctacgagtct acctagctaa agaaaataaa tggctagata ttcatactga
     4201 gcaaaaccac agccatttta actttgtcaa agaatgccga ctggacaaaa cactcgtatc
     4261 aactattcaa caccaagacc tcctaaaagc tgaacaacta actttcaccc tcagctggct
     4321 accaaatcac taataaccaa aagaaccttt gcatcgcgca aaggttcttc ttttatgaaa
     4381 cttggacttg aagttgatcc acaagctgac catccaccgt taggttcaga tagaaatcca
     4441 aggttttatc tcctgcgaaa tacagggttg gtagatgcaa atcttttttg ctttcccctg
     4501 cttggaattg aaggacttga atctcatcct gataggcgac accatggaca cctgtccccg
     4561 gttgaatcga aatcttagcc tctaaagagg agctactttc actacgttca atcctaaaat
     4621 gaagagtctc tccctttgcc acagctaggc ttttttctgc aaatgctagc ccctgaacag
     4681 ctactgtttg tgataacctc ggagttttat agagtgaaat cttggtcaac aaaggcaaag
     4741 cctgtgattc tgtaatgact acacgtatct tctgtgcttc aacaactgct cctcgcaaga
     4801 ggcgcttatg accaactgtg aagcccctgc caaattcctg ccagacacca tccacctcta
     4861 cttgcacatg gaaagcagaa atacgttggc ctaacttcaa atcttctctc aactcaatta
     4921 catcaaaagt tttaggagaa cctaagtcga gttctaactg gatgggcaag tctgcatcg
//
LOCUS       DBMVGT010000097         4949 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.097, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000097 DBMVGT010000000
VERSION     DBMVGT010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4949)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4949)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4949
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.097"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            77..439
                     /locus_tag="AC0DU4_001955"
     CDS             77..439
                     /locus_tag="AC0DU4_001955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-export chaperone SecB"
                     /protein_id="HIN4237864.1"
                     /translation="MLEVGLNFLISLFTFTFDILYPIVKVGHTDDYSHGAVKLSVSLV
                     DKDAMKKISVTVIGYFEINIDENITDILYVNGTAILYHYLRSIVSIVSAIDSSEAMLL
                     PTINVLELLDKSQPFEEE"
     gene            838..1083
                     /locus_tag="AC0DU4_001956"
     CDS             838..1083
                     /locus_tag="AC0DU4_001956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007284765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237865.1"
                     /translation="MKAFYITIEKFIRDDESLKCYFIKVISSRSKVTSLDQIEADKTI
                     QRKYSSELKKFIGFYNEIICEENSFLHVRKRWSSWFR"
     gene            1484..2476
                     /locus_tag="AC0DU4_001957"
     CDS             1484..2476
                     /locus_tag="AC0DU4_001957"
                     /EC_number="7.5.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237866.1"
                     /translation="MAMIEVEHLQKNFVKTVKEPGLKGALRSFIHPEKQTFEAVKDLT
                     FEVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGFCRINGKIPQDNRQDYVKDIGVV
                     FGQRTQLWWDLALQETYTVLKEIYDVPNSLFHKRMDFLNEVLDLKDFIKDPVRTLSLG
                     QRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLS
                     DIEQLCDRIFMIDKGQEIFDGTVSQLKETFGKMKTLSFELLPGQSHLVSHYEGLSDMT
                     IDRQGNSLNIEFDSSRYQSADIIKQTLSDFEIRDLKMVDTDIEDIIRRFYRKEL"
     gene            2478..3296
                     /locus_tag="AC0DU4_001958"
     CDS             2478..3296
                     /locus_tag="AC0DU4_001958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237867.1"
                     /translation="MIKLWRRYKPFINAGVQELITYRVNFILYRIGDVMGAFVAFYLW
                     KAVFDSSQESLIQGFSMADITLYIIMSFVTNLLTRSDSSFMIGEEVKDGSIIMRLLRP
                     VHFAASYLFTELGSKWLIFISVGLPFLSVIVLMKIISGQGIVEVLGLTVLYLFSLTLA
                     YLINFFFNICFGFSAFVFKNLWGSNLLKTSIVAFMSGSLIPLAFFPKVVSDILSFLPF
                     SSLIYTPVMIIVGKYDASQILQALLLQFFWLLVMVGLSQLIWKRVQSFITIQGG"
     gene            3298..4083
                     /locus_tag="AC0DU4_001959"
     CDS             3298..4083
                     /locus_tag="AC0DU4_001959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237868.1"
                     /translation="MKKYQRMHLIFIRQYIKQIMEYKVDFVVGVLGVFLAQGLNLLFL
                     NVIFQHIPFLEGWTFQEIAFIYGFSLIPKGMDHLFFDNLWALGQRLVRKGEFDKYLTR
                     PINPLFHILVETFQIDALGELLVGGILLGTTVTSIVWTLPKFLLFLVCIPFATLIYTS
                     LKIATASIAFWTKQSGAMIYIFYMFNDFAKYPISIYNSLLRWLISFIVPFAFTAYYPA
                     SYFLQEKDVFFNVGGLMLISLVFFVISLKLWDKGLDSYESAGS"
     gene            4181..4399
                     /locus_tag="AC0DU4_001960"
     CDS             4181..4399
                     /locus_tag="AC0DU4_001960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family acetyltransferase"
                     /protein_id="HIN4237869.1"
                     /translation="MKDLPEWFGIPESTQAYIEGTTTLQVWTAYQESDLTGFVRLSYS
                     SEDCAEIDCLGVKKLIKVEKLGANCLLL"
     gene            4384..4581
                     /locus_tag="AC0DU4_001961"
     CDS             4384..4581
                     /locus_tag="AC0DU4_001961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4237870.1"
                     /translation="MLATLESEARKKVGYLQVKTVAEASNKDYDRTNDFYRGLGFKKL
                     EIFSQLWNPQNPCQILIKKLE"
BASE COUNT         1418 a          817 c         1038 g         1676 t
ORIGIN      
        1 aacttcaaaa cagtgttttg agcaacctgc ggctagtttc ctagtttgct ctttggtttt
       61 cattgagtat aacagattgt tagaagttgg tttaaatttc ctaatcagtt tgttcacatt
      121 taccttcgat atattatatc ccatagttaa ggttggtcat acagatgatt atagtcatgg
      181 agccgtaaaa cttagtgttt ctttagttga caaagatgcc atgaaaaaaa tatctgtaac
      241 tgtaatagga tattttgaaa taaatataga tgaaaatatc accgatattc tatacgtaaa
      301 tggtactgct attctttatc attatttacg ttctattgtt tcaatagttt cggcaattga
      361 tagcagtgaa gcaatgttgc tacctaccat taatgtttta gagttactag ataaatctca
      421 accttttgaa gaagaataat ttattagctc actaaattga gggtaaggaa aagtaaaatc
      481 agtaagaaaa atgtcttgca ttatacagca accttttggg aatgagtaga tggattgaat
      541 aaaattttat taagagtgga tgatttatct gtagattatt attggacagt tagtcttgaa
      601 gtagtctaag aattaggtta taatcagtag aatccttgct aataatgagg aggttagttt
      661 atgtatagta gactgaatct aaaatagtac gaaacaattg ctaaaacatt tatagaaatt
      721 aattttactt tcccaatcga tttgttctca tcttatttca atccgctata tattatggta
      781 tcgaatcttc atcagaatga taaaattaat caattgatat ctgattacaa acagaatatg
      841 aaagcttttt atatcactat tgaaaaattt atacgagatg atgaaagcct taagtgttat
      901 tttataaagg ttatttcaag tcgttccaag gtaacaagtc tagatcagat tgaagctgat
      961 aaaacgatac aaagaaaata ttcaagtgag ctaaaaaaat ttattggatt ttataatgag
     1021 attatttgtg aggaaaatag tttcctacat gtacgaaaga ggtggtcgag ttggtttagg
     1081 tagtcgatgc gtgagttgat aattctcagg gtatggactt ctttttcatg aatgaggtaa
     1141 aagagcaggt attgtttaga gacaatcatt ctgagcatat tttctggata gagggagtat
     1201 ccgattttat gatcaaagtt aataccgccc tctggtgaga agatgagtag gttggtaatt
     1261 taaactatta aacagaattt ttgattaaaa gtattatttt atgagagaaa tcctaatttc
     1321 acaatccata ggcaaactct tgcatttcgt tttttattgg actataatag gttggtataa
     1381 agccttttgt agtaataaaa tgtagaaggt gtagaaagca aggatttaga atatttgtag
     1441 ttaaaaacac aatgttgcta ttccttacga tagggagata gatatggcaa tgatagaagt
     1501 ggaacatctt cagaaaaatt ttgtgaagac tgttaaggaa ccgggcttga agggggcttt
     1561 gcgctccttt attcatcctg aaaagcagac ctttgaagcg gtcaaggatt tgacctttga
     1621 ggttccaaaa gggcagattt taggatttat cggggcaaat ggtgctggga agtcgacaac
     1681 cattaaaatg ctgacaggaa ttttgaaacc aacatctggt ttttgtcgga ttaacggcaa
     1741 gattccccag gacaatcggc aagattatgt caaagatatt ggcgtagtct ttggacaacg
     1801 cacccagcta tggtgggatt tggctctgca agagacctac actgtcttaa aagagattta
     1861 tgatgtgcca aactcgctct ttcataagcg catggacttt ttgaatgaag tcttggattt
     1921 gaaggacttt atcaaggatc ccgtgcggac tctttcactg ggacaacgga tgcgggcgga
     1981 tattgcggcc tccttgctcc acaatcccaa ggttcttttt ttagatgagc cgaccattgg
     2041 tttggacgtt tcggttaagg ataatattcg tcgggcaatt actcagatca atcaagagga
     2101 agaaactacc attcttttga ccactcacga tttgagtgat attgagcaac tttgtgatcg
     2161 gattttcatg attgacaagg ggcaagagat ttttgatgga acggtgagcc aactcaagga
     2221 gacctttggt aagatgaaga ctctctcttt tgaactgcta ccaggtcaaa gtcatctcgt
     2281 ctctcactat gaaggtctgt ctgatatgac cattgataga caaggaaaca gcctcaacat
     2341 tgaatttgat agttctcgct accagtcagc tgacattatc aagcaaaccc tgtctgattt
     2401 tgaaatccgc gatttgaaga tggtggatac ggatattgag gatattatcc gtcgcttcta
     2461 ccgaaaggag ctctaggatg atcaaattgt ggagacgtta taaacccttt atcaatgcag
     2521 gggttcagga gttgattact taccgagtca actttattct ctatcggatt ggcgatgtca
     2581 tgggggcttt tgtggccttt tatctctgga aggctgtctt tgattcttcg caagagtctt
     2641 tgattcaggg cttcagtatg gcggatatca ccctctacat catcatgagt tttgtgacca
     2701 atcttctgac tagatccgat tcgtccttta tgattgggga ggaggtcaag gatggctcca
     2761 ttatcatgcg tttgttgcga ccagtgcatt ttgcggcctc ctatcttttc accgagcttg
     2821 gttccaagtg gttgattttt atcagcgttg gccttccatt tttaagtgtc attgtcttga
     2881 tgaaaatcat atcgggtcaa ggtattgtag aggtgctagg attaactgtc ctttatcttt
     2941 ttagcttaac gctcgcctat ctgattaact ttttctttaa tatttgcttt ggattttcag
     3001 cctttgtgtt taaaaatctt tggggttcca acctacttaa gacttccata gtggctttta
     3061 tgtcggggag tttgattccc ttggcattct ttccaaaggt tgtttcagat attctttcct
     3121 ttttgccttt ttcatccttg atttatactc cagttatgat cattgttgga aaatacgatg
     3181 ccagtcagat tcttcaggca ctccttttgc agttcttctg gctcttagtg atggtgggat
     3241 tgtctcagtt gatttggaaa cgggtccagt cctttatcac cattcaagga ggttagtatg
     3301 aaaaaatatc aacgaatgca tctgattttt atcagacaat acatcaaaca aatcatggaa
     3361 tataaggtgg attttgtggt tggtgtcttg ggagtctttc tggctcaagg cttgaatctc
     3421 ttgtttctca atgtcatctt tcaacatatt ccattcctag aaggctggac ctttcaagag
     3481 atagctttca tttatggatt ttccttgatt cccaagggaa tggaccatct cttttttgac
     3541 aatctctggg cactagggca acgcctagtc cgaaaagggg agtttgacaa gtatttgact
     3601 cgtcccatca atcctctctt tcacatccta gttgaaacct ttcagattga tgccttgggt
     3661 gaactcttag tcggtggtat tttattggga acaacagtga ccagcattgt ttggactctt
     3721 ccaaaattcc tgcttttcct agtttgtatt ccttttgcga ccttgattta tacttctctt
     3781 aaaatcgcaa cagccagtat cgccttttgg actaagcagt caggcgccat gatttacatc
     3841 ttctatatgt tcaatgactt tgctaagtat ccgatttcta tttacaattc tcttcttcgt
     3901 tggttgatta gctttatcgt gcctttcgcc tttacagcct actatccagc tagctatttc
     3961 ttacaggaaa aggatgtgtt ctttaacgta ggaggtttga tgttgatttc tctggttttc
     4021 tttgttattt cccttaaact ttgggataag ggcttagatt cctacgaaag tgcgggttcg
     4081 taaaagctaa agtaagacta aaatcaagaa aggaacttat gatgtttgta attgaagaag
     4141 tcaaggatga aaatcaaaaa aggcagttgt cgctgaggtt ttgaaggatt tgccagaatg
     4201 gtttggaatc ccagaaagca cacaagccta tatagaagga accacgacac tgcaagtttg
     4261 gaccgcctat caggagagtg atttgactgg atttgtaagg ttatcctatt cgagtgaaga
     4321 ttgtgcagag attgattgtc tcggcgtaaa aaagcttatc aaggtagaaa aattgggagc
     4381 caattgcttg ctactttaga gagtgaagct cgtaaaaaag ttggttatct gcaggtcaaa
     4441 acagtggcag aagcttctaa taaagattat gatcgaacaa atgactttta tcgaggtctt
     4501 ggctttaaaa agttagagat tttttctcag ctatggaatc cgcaaaatcc ttgtcagatt
     4561 ttgattaaaa agcttgaata atattacttg acatctattc tcagagtgcc atactgtaag
     4621 tgtaatcgcc gatttagctc agttggtaga gcaaggcact cgtaaagcct aggttatagg
     4681 tagataaacg actgaggagt tgaaaaaata gataggtaga agataaccgt taagccttat
     4741 tcttagcggt tatttatatt atttaatagc gctgatattt catcaattat gcctgttttc
     4801 gtgtttctgg tagttgttca agtttattgc tactattttt gatggtatga atgtgcttat
     4861 aatgtatccc ggttaacgaa agttttggac ttatactctt cgaaaatctc ttcaaaccac
     4921 gtcaacgtcg ccttgccgtg cgtatggtt
//
LOCUS       DBMVGT010000098         4355 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.098, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000098 DBMVGT010000000
VERSION     DBMVGT010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4355)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4355)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4355
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.098"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..230
                     /locus_tag="AC0DU4_001962"
     CDS             <1..230
                     /locus_tag="AC0DU4_001962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HIN4237871.1"
                     /translation="GNKWYYLRSSGAMVTGWYQDGSTWYYLDAENGDMKIGWTKVNGK
                     WYYLNSSGAMVTGSQTIDGKVYNFASSGEWI"
     gene            249..1247
                     /gene="cbpJ"
                     /locus_tag="AC0DU4_001963"
     CDS             249..1247
                     /gene="cbpJ"
                     /locus_tag="AC0DU4_001963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpJ"
                     /protein_id="HIN4237872.1"
                     /translation="MKLLKKTMQAGLTVIFFGLLATNTVFADNSEGWQFVQENGRTYY
                     KKGDLKETYWRVIDGKYYYFDSLSGEMVVGWQYIPFPSKGSTIGPYPNGMRLEGFPNS
                     EWYYFDKNGVLQEFVGWKTLEIKTKDSVGRKYGEKREDSEDKEEKRYYTNYYFNQNHS
                     LETGWLYDQSNWYYLAKTEINGENYLGGERRAGWINDDLTWYYLDPTTGIMQTGWQYL
                     GNKWYYLRSSGAMATGWYQEGTTWYYLDQPNGDMKTGWQNLGNKWYYLRSSGAMATGW
                     YQDGSTWYYLNAGNGDMKTGWFQVNGNWYYAYSSGALAVNTTVDGYSVNYNGEWVR"
     gene            complement(1365..2597)
                     /locus_tag="AC0DU4_001964"
     CDS             complement(1365..2597)
                     /locus_tag="AC0DU4_001964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HIN4237873.1"
                     /translation="MKLFWTNNIYRQLLLNSCFSSFGDSIFYLAIINYVAQYNFAPLA
                     ILLISISEMVPLLSQLFLGILGDFQENRVKHALWIAKIKILLYAILTVFLVLSPFSLV
                     SVIMIVIINLISDTLSYLSAYMMNALYISVIKDDLHDAMGFRQSLMRVVRIVANLAGA
                     FLINVISIQTISLINTLTFVIAFLGLYVIRHTLYEVEKRIEMSHTALSFKKYFQHLKQ
                     SLAVLLRLKDTVILLFLTTSMIAILDVSPRLIALRFIQQTLAQLSIGQLLALLSIIMS
                     CGAILGNMTSSNLFKNIRFTHLLVFCEISLLTLITSILCQAYIVIFMTSFISSTIIGI
                     LSPRLQAAVFAHIPSDKMGTVGSALSTVDILAPSLLSLLALSIASGVSVQLALIFLYL
                     ILIALIFCQWLVKFNTHN"
     gene            complement(2640..3515)
                     /locus_tag="AC0DU4_001965"
     CDS             complement(2640..3515)
                     /locus_tag="AC0DU4_001965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="HIN4237874.1"
                     /translation="MYPPELDSKILSIIKKAVTIRTTHTYEYQYSLLFGDAGYLWLLL
                     HLFSISKNQYYLQLANVTAKKLIENYDTLEEIDFALGKSGVLLSLIKYYQFTNDNTLK
                     IFIHNSIGEIYHYFLQRDTAKESILDYSFAHGYCGIAYALFAYSKVLEPSMFYNDLHT
                     FHTELKKLLEKVTSNTENLGNLQLSWCKGISGIILYLCMYDCDGNKDIISKYQEFVFN
                     HHLKMMTGYCHGITSLLQTTVYNQNKLLMKKIQQVILACSERDDHGLLMFQGDSGKAD
                     LFDFGIGSMGYIGVY"
     gene            4126..>4355
                     /locus_tag="AC0DU4_001966"
     CDS             4126..>4355
                     /locus_tag="AC0DU4_001966"
                     /inference="COORDINATES: protein motif:HMM:NF024736.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA];
                     GO_process: GO:0015074 - DNA integration [Evidence IEA];
                     GO_process: GO:0032196 - transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HIN4237875.1"
                     /translation="MTRKVYDTDLNDQEWAKIEPYFSKHRTYKWPKRVLVNETLYVTK
                     TGCQWRMLPHDFPLYLMVWSFFRRSMTTGWFQV"
BASE COUNT         1410 a          706 c          911 g         1328 t
ORIGIN      
        1 ttggtaacaa gtggtactac ctccgttcat caggagctat ggtaactggc tggtatcaag
       61 atggttcaac ttggtactat ttagatgctg aaaatggtga tatgaaaata ggttggacaa
      121 aagtaaatgg aaaatggtat tatctcaatt cctctggagc aatggttaca ggtagtcaaa
      181 ctatcgatgg taaagtttat aacttcgctt catctggtga gtggatttaa tgttggagga
      241 tatataaaat gaagcttttg aaaaaaacta tgcaagctgg actaacagta attttctttg
      301 gtttgctagc tacgaataca gtatttgcag ataactctga aggatggcag tttgtccaag
      361 aaaacggtag aacctattac aaaaaggggg acctcaaaga aacctactgg cgagtgattg
      421 atggtaagta ctattatttt gattctctat ctggagagat ggttgtcggc tggcaatata
      481 tcccgtttcc atctaaaggt agtacaattg gtccttaccc aaatggtatg agattagaag
      541 gttttccaaa ttcagagtgg tactacttcg ataaaaatgg agtgctacaa gagtttgttg
      601 gttggaaaac attagagatt aaaactaaag acagtgttgg aagaaagtac ggggaaaaac
      661 gtgaagattc agaagataaa gaagagaaac gttattatac gaactattac tttaatcaaa
      721 atcattcttt agagacaggt tggctttatg atcagtctaa ctggtattat ctagctaaga
      781 cggaaattaa tggagaaaac taccttggtg gtgaaagacg tgcggggtgg ataaacgatg
      841 atttgacttg gtactattta gatccaacaa ctggtattat gcaaacaggt tggcaatatc
      901 taggtaataa gtggtactac ctccgttcct caggagcaat ggccactggc tggtatcagg
      961 aaggtaccac ttggtattat ttagaccagc caaatggcga tatgaaaaca ggttggcaaa
     1021 accttgggaa caaatggtac tatctccgtt cctcaggagc aatggcaact ggttggtatc
     1081 aagatggttc aacttggtac tacctaaatg caggtaatgg agatatgaag acaggttggt
     1141 tccaggtcaa tggcaactgg tactatgctt atagctcagg tgctttggca gtgaatacga
     1201 ccgtagatgg ctattctgtc aactataatg gcgaatgggt tcggtaatga cagggcgctt
     1261 ataattatat tagaacactc gcttaatcaa agaagtgact ttgttgtact tgacctgacg
     1321 attggggaga ttaaaagcat gtgaaatcta cacatgcttt ttcgttagtt atgagtgttg
     1381 aacttgacta accattgaca aaagataaga gcaattaaaa taagatacaa aaatatcaat
     1441 gctaactgca ccgaaacgcc cgatgctatg gatagggcta atagggagag cagggacggg
     1501 gcgagaatgt ccactgtgct cagagcagag cccaccgtcc ccatcttgtc actggggata
     1561 tgggcaaaga cagctgcttg taggcgaggg ctgagaatgc cgataatcgt agaactgatg
     1621 aaactggtca tgaaaattac gatataggct tgacaaagga tactagttat tagagtcaat
     1681 agggaaatct cacagaaaac caagaggtgc gtgaaacgga tatttttaaa tagattactg
     1741 ctggtcatat tgccaaggat agctccacaa gacatgatga tggagagcag ggcgaggagt
     1801 tgcccaatgc tcagttgtgc tagtgtctgt tggatgaagc ggagggcaat cagccgaggg
     1861 gacacatcca agatggcaat catactggtc gtcagaaaca gtagtatgac ggtatctttt
     1921 aacctcagga gcacagccag cgactgttta agatgttgaa aatatttctt aaaactcagt
     1981 gctgtatgtg acatttcaat tcttttttca acctcataca aggtatgtcg aataacatac
     2041 aggcccaaaa aggcaatgac aaaagtcaga gtgttgataa gggaaatagt ttgaatactt
     2101 ataacattga taaggaatgc gccagccaga ttggcgacaa tacggacaac cctcatcaga
     2161 gactgcctga accccatggc atcatgcagg tcgtccttaa ttacactgat gtagagggcg
     2221 ttcatcatgt aggcagacag gtagctcaag gtgtcagaga tgaggttgat gatgacaatc
     2281 ataatgactg aaactaatga aaagggcgac aagacgagaa atactgtcaa aatagcgtag
     2341 agcaggattt tgattttggc aatccagagt gcgtgtttga ctctattttc ttgaaaatct
     2401 cctagaatcc cgagaaagag ttgcgatagt aggggaacca tctctgaaat ggaaatcagt
     2461 aaaatcgcta gcggagcgaa attgtactga gccacataat tgataatggc gaggtagaaa
     2521 atactgtcgc cgaatgatga aaaacagctg tttagcagca actgtctata tatgttgttt
     2581 gtccaaaata atttcatact tttctcctta tgtctgcaca tcgaatggga atttattatt
     2641 taatagacac caatataccc catgcttcct attccgaagt caaacaaatc tgctttacca
     2701 ctatctcctt gaaacatcag taaaccgtga tcatctcgtt cagaacatgc taaaattacc
     2761 tgttggattt ttttcatcag taatttgttt tgattgtaga cagtggtttg tagtaagcta
     2821 gttattccgt ggcaatatcc tgtcatcatt tttagatgat ggttaaaaac aaattcttga
     2881 tatttactaa taatatcttt gtttccgtca caatcgtaca tacaaagata taagattatt
     2941 ccggaaattc ctttgcacca agaaagttgt aaatttccta aattttcagt attagaagta
     3001 actttttcta ataatttttt taattcagta tggaatgtat ggagatcatt atagaacata
     3061 gaaggttcta agactttaga ataggcaaat aaagcatatg caattccaca atatccatga
     3121 gcaaagctat agtctaaaat gctttctttg gctgtatctc tttgtaggaa ataatgataa
     3181 atttccccta tactattgtg gatgaaaatt ttaagagtat tgtcattggt aaattgatag
     3241 tattttatta atgataatag gacaccagat tttcccaatg caaagtctat ttcctctaga
     3301 gtatcataat tctctattaa ttttttagcg gtgacgtttg ctaattgtag atagtattga
     3361 tttttactga tagaaaataa atgtaggagt aaccatagat agcctgcatc accaaatagc
     3421 agtgagtatt gatattcata tgtatgtgtc gttctaattg tcactgcctt cttgatgata
     3481 gagagtattt tagaatccag ttctgggggg tacaatttat ttagaggaaa cagtagtcca
     3541 gctattccgt gttggaatga taaattactt acgaaatttc caaattctgt tgaagaagtg
     3601 atccttcctt cagaatttac agttttatct agtaaaaatt gtagaacact attacattct
     3661 gttttgtaat catatttatg ttcctctatt tttttaattt tgactaaatt atttgtttga
     3721 cttaaattta gtagacattg taaccaaaat agttgctcat ctgtgagctg accttgagta
     3781 tgtgatagtt ctagtaattg aataggatcc tttagttaga ttcaatcaat ctataacaca
     3841 acaacataat aatactttta ggataactta tcaaatatta tagtaaaatg agataataac
     3901 aggataaatc gatcaggaca gtcaaatcga tttctaacaa tattttagaa gtagaggtgt
     3961 actattctag tttcaatcta ctatagtata tatttttaca tcttgaattg tcaaattaag
     4021 tgcataactt tcccgtagca tacttcataa ggcgttttcc acttaagaaa ttttcgtggt
     4081 cgattattta gaacctgtat tcacaaaaaa tgttaaacta gagttatgac acgcaaagta
     4141 tatgatactg atttaaacga tcaagaatgg gctaagattg aaccctattt ctccaaacac
     4201 cgcacctata aatggccgaa acgagtactt gttaatgaga ctttgtacgt cactaaaaca
     4261 ggttgtcaat ggcgcatgct ccctcacgac tttcctcttt acttaatggt atggagtttc
     4321 tttcgtcgtt ctatgacgac aggttggttc caggt
//
LOCUS       DBMVGT010000099         4344 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.099, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000099 DBMVGT010000000
VERSION     DBMVGT010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4344)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4344)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4344
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.099"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..824
                     /locus_tag="AC0DU4_001967"
     CDS             <1..824
                     /locus_tag="AC0DU4_001967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HIN4237876.1"
                     /translation="IEANKACRANQIKEVIVTGWGDNGGETAQFSILPSLQIWAELSY
                     RNDLDSLSAHFKTNTGLTVEDFMQIDLANLLPDLPGNLSGINPNRYVFYQDILCPILD
                     QHMTPEQDKPHFAQAAETLANIKEKAGNYAYLFETQAQLNAILSSKVDVGRRIRHAYQ
                     ADDKESLQQIARQELPELRSQIEDFHALFSHQWLKENKVFGLDTVDIRMGGLLQRIKR
                     AESRIEVYLAGQLDRIDELEVEILPFTDFYADKDFAATTANQWHTIATASTIYTT"
     gene            1214..1540
                     /locus_tag="AC0DU4_001968"
     CDS             1214..1540
                     /locus_tag="AC0DU4_001968"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812968.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1096 element passenger TnpR family protein"
                     /protein_id="HIN4237877.1"
                     /translation="MILWSFDFANDHAHAFFMDNVEWSHADSYFFSFVSDDVEERYTE
                     NVYLDSLSVKQKFKFIFDFGDEWRFECQVLREIETEDEEAYLVRSVGTSPEQYPDYDG
                     FDYEEW"
     gene            complement(1592..2434)
                     /locus_tag="AC0DU4_001969"
                     /pseudo
     CDS             complement(1592..2434)
                     /locus_tag="AC0DU4_001969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            complement(2417..2572)
                     /locus_tag="AC0DU4_001970"
                     /pseudo
     CDS             complement(2417..2572)
                     /locus_tag="AC0DU4_001970"
                     /inference="COORDINATES: protein motif:HMM:NF016232.6"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="AlbA family DNA-binding domain-containing
                     protein"
     gene            2907..>4344
                     /gene="pcpA"
                     /locus_tag="AC0DU4_001971"
     CDS             2907..>4344
                     /gene="pcpA"
                     /locus_tag="AC0DU4_001971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000753909.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein PcpA"
                     /protein_id="HIN4237878.1"
                     /translation="MKKTTILSLTTAAVILAAYVPNEPILADTPSSEVIKETKVGSII
                     QQNNIKYKVLTVEGNIGTVQVGNGVTPVEFEAGQDGKPFTIPTKITVGDKVFTVTEVA
                     SQAFSYYPDETGRIVYYPSSITIPSSIKKIQKKGFHGSKAKTIIFDKGSQLEKIEDRA
                     FDFSELEEIELPASLEYIGTSAFSFSQKLKKLTFSSSSKLELISHEAFANLSNLEKLT
                     LPKSVKTLGSNLFRLTTSLKHVDVEEGNESFASVDGVLFSKDKTQLIYYPSQKNDESY
                     KTPKETKELASYSFNKNSYLKKLELNEGLEKIGTFAFADAIKLEEISLPNSLETIERL
                     AFYGNLELKELILPDNVKNFGKHVMNGLPKLKSLTIGNNINSLPSFFLSGVLDSLKEI
                     HIKNKSTEFSVKKDTFAIPETVKFYVTSEHIKDVLKSNLSTSNDIIVEKVDNIKQETD
                     VAKPKKNSNQGVVGWVKDKGLWYYLNESG"
BASE COUNT         1423 a          753 c          793 g         1375 t
ORIGIN      
        1 ctatcgaggc taataaagcc tgccgtgcca atcagattaa agaagtcatc gtaactggtt
       61 ggggagacaa tggtggtgaa actgcccagt tctctatcct accaagcttg caaatctggg
      121 cagaactcag ctatcgcaat gacctagata gtttgtctgc gcacttcaag accaatactg
      181 gtctaacggt tgaggatttt atgcagattg atcttgccaa cctcttacca gacctaccag
      241 gcaatctcag cggtatcaat cccaaccgct atgtttttta tcaggatatt ctttgtccga
      301 ttcttgatca acacatgaca cctgaacagg acaaaccgca cttcgctcag gctgctgaga
      361 cgcttgctaa cattaaagaa aaagctggaa actatgctta tctctttgaa actcaggccc
      421 agttgaatgc tattttaagt agcaaagtag atgtgggacg acgcattcgt catgcctacc
      481 aagcggatga taaagaaagt ttacaacaaa tcgccagaca agaattacca gaacttagaa
      541 gccaaattga agacttccat gccctcttta gccaccaatg gctgaaagaa aacaaggtct
      601 ttggtttgga tacagttgac atccgtatgg gcggactctt gcaacgcatc aaacgagcag
      661 aaagccgtat cgaggtttat ctggctggtc agcttgaccg catcgacgag ctggaagttg
      721 aaatcctacc atttactgac ttctacgcag acaaggactt cgcagcaact acagctaacc
      781 agtggcatac cattgcgaca gcgtcgacga tttatacgac ttaatactct tcgaaaatct
      841 cttcaaacca cgtcagcttc catctacaac ctcaaaacag tgttttgagc agcctgcagc
      901 tagcttccta gtttgctctt tgattttcat tgagtataaa aacaagaaca ccttgcttgg
      961 cgcagggtgt ttcgcgtgaa acagaagaat tatctggttt caaatgctac agttagacaa
     1021 acttatgata aaatagcaga aagtgaatgt ttcctaagag caattctatc gatgagcaat
     1081 tggaggtatt atgctacact taaaattagt aaaacaagaa atagaagctt gggtcatttc
     1141 cgtcaaattt aaaaaaggtt gctaccgaca tatatagatt ccaaaaacaa aaacgttagc
     1201 gaaactagca gatgtgattt tatggagttt tgattttgca aatgatcatg ctcacgcatt
     1261 tttcatggat aatgttgagt ggagtcatgc agattcttac ttttttagct ttgttagtga
     1321 cgatgttgaa gaacgttaca cagaaaatgt ctatctggat agcctaagtg tcaaacaaaa
     1381 atttaagttt attttcgact tcggtgatga atggcgtttt gaatgccaag tgctgagaga
     1441 aatcgagaca gaggacgaag aagcttatct cgtacgttcg gttggaacgt cgccagaaca
     1501 atatccagat tatgatggtt ttgactatga agaatggtaa aattgaaatc agtctgtgta
     1561 ggcttagtat ttcaatagac ttcctgcaaa actagaatcc tagttcatga ttgataatac
     1621 cagcactcaa attcattcgt aatccgaagc gtttacgatg atttcgatag gttgttgaaa
     1681 ttattttaaa cgtttttact ttggcaaaga tgttctcaac cttgcttctc tccttggata
     1741 gcgcatggtt acaggcttta tcttcaactg ttagcggctt gagtttgctg gatttacgtg
     1801 gagtttgtgc ttgaggatat atcttcatga gcccttgata accactgtca gccaagattt
     1861 taccagcttg tccgatattt ctgcaactca ttttgaacaa cttcatatca tgacaatagt
     1921 tcacagtgat atccaaagaa acaattctcc cttgacttgt gacaatcgct tgagccttca
     1981 tagcgtgaaa tttcttttta ccagaatcat tcgctaattg tttttttagg gcgattgatt
     2041 tttacttccg tcgcatcaat cattaccgtg tcctcagaac tgagaggagt tcttgaaacc
     2101 gtaaaaccac tttgaacaag agttacttca acccattggc tccgacggat aaagttgctt
     2161 tcgtgaatac caaaatcagc cgcaatttct tcataagttc gatattctcg cactattgaa
     2221 gagtgggcat aagaaggtct tctaggctta atttaggttt tcgtccacct tttgcgtgtt
     2281 taagttgata agctgttttt aatacagcta acatctcttc aaaagtcgtg cgttgaacac
     2341 caacaagacg cttaaatcgt gcatcggtta gttgtttact tgcttcataa ttttgtttcg
     2401 cagggagtct attgactctt tggtaggtgt caatgttttt ttcatctatc ccgagaatta
     2461 ttttcccgcc atttgtattt gcaaatgctg agtaggtttc ccagaaagac tctggaagat
     2521 tgtttttagc ttttttgtat tctaaatcaa ccccttcaaa ttttaagtcc atatttttcc
     2581 tttacatctg ttttttgtgg ttctggtatt tgttcaagtt gagtgataat atagcgaatt
     2641 gaatttcgag agtttttact cagttaattt cttttttaac ccactttaat ttctttttta
     2701 acacgggtta aaaaagaaat taaagtgggt taattttcct tgacttaaaa tttaaaaatg
     2761 atatactgtg tttatggaga gatgacaatt tataaaatgt actactctat tctactagat
     2821 aatgattgaa taaaactttt tataacaacg gctagcaaag ttataatttt atatctatta
     2881 gaaaataaat atgtaaggaa atttaaatga aaaaaactac aatattatca ttaactacag
     2941 ctgcggttat tttagcagca tatgtcccta atgaaccaat cctagcagat actcctagtt
     3001 cggaagtaat caaagagact aaagttggaa gtattattca acaaaataat atcaaatata
     3061 aggttctaac tgtagaaggt aacataggaa ctgttcaagt gggtaatgga gttactcctg
     3121 tagagtttga agctggtcaa gatggaaaac cattcacgat tcctacaaaa atcacagtag
     3181 gtgataaagt atttaccgtt actgaagtag ctagtcaagc ttttagttat tatccagatg
     3241 aaacaggtag aattgtctac tatcctagct ctattactat cccatcaagc ataaaaaaaa
     3301 tacaaaaaaa aggcttccat ggaagtaaag ctaaaactat tatttttgac aaaggcagtc
     3361 agctggagaa aattgaagat agagcttttg atttttctga attagaagag attgaattgc
     3421 ctgcatctct agaatatatt ggaacaagtg cattttcttt tagtcaaaaa ttgaaaaagc
     3481 taaccttttc ctcaagttca aaattagaat taatatcaca tgaggctttt gctaatttat
     3541 caaatttaga gaaactaaca ttaccaaaat cggttaaaac attaggaagt aatctattta
     3601 gactcactac tagcttaaaa catgttgatg ttgaagaagg aaatgaatcg tttgcctcag
     3661 ttgatggtgt tttgttttca aaagataaaa ctcaattaat ttattatcca agtcaaaaaa
     3721 atgacgaaag ttataaaacg cctaaggaga caaaagaact tgcatcatat tcgtttaata
     3781 aaaattctta cttgaaaaaa ctcgaattga atgaaggttt agaaaaaatc ggtacttttg
     3841 catttgcgga tgcgattaaa cttgaagaaa ttagcttacc aaatagttta gaaactattg
     3901 aacgtttagc cttttacggt aatttagaat taaaagaact tatattacca gataatgtta
     3961 aaaattttgg taaacacgtt atgaacggtt taccaaaatt aaaaagttta acaattggta
     4021 ataatatcaa ctcattgccg tccttcttcc taagtggcgt cttagattca ttaaaggaaa
     4081 ttcatattaa gaataaaagt acagagtttt ctgtgaaaaa agatacattt gcaattcctg
     4141 aaactgttaa gttctatgta acatcagaac atataaaaga tgttcttaaa tcaaatttat
     4201 ctactagtaa tgatatcatt gttgaaaaag tagataatat aaaacaagaa actgatgtag
     4261 ctaaacctaa aaagaattct aatcagggag tagttggttg ggttaaagac aaaggtttat
     4321 ggtattactt aaacgaatca ggtt
//
LOCUS       DBMVGT010000100         4309 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.100, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000100 DBMVGT010000000
VERSION     DBMVGT010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4309)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4309
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.100"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(153..428)
                     /locus_tag="AC0DU4_001972"
     CDS             complement(153..428)
                     /locus_tag="AC0DU4_001972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HIN4237879.1"
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQ
                     LIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK"
     gene            complement(535..1374)
                     /locus_tag="AC0DU4_001973"
     CDS             complement(535..1374)
                     /locus_tag="AC0DU4_001973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000161411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HIN4237880.1"
                     /translation="MTKIKIVTDSSVTIEPELVKQLDITIVPLSVMIDNVVYSDADLK
                     EEGKFLQLMQESKNLPKTSQPPVGVFAEIFEDLCKDGGQILAIHMSHALSGTVEAARQ
                     GASLSTADVTVVDSSFTDQALKFQVVEAAKLAQEGKDMEAILSHVEEVKNHTELYIGV
                     STLENLVKGGRIGRVTGLLSSLLNIRVVMQMKDHELQPMVKGRGTKTFKKWLDELITS
                     LSERAVAEIGISYSGSDDWAKEMKESLQVYVEKPISVLETGSIIQTHTGENAWAILIR
                     YHS"
     gene            1516..2364
                     /locus_tag="AC0DU4_001974"
     CDS             1516..2364
                     /locus_tag="AC0DU4_001974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000592058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HIN4237881.1"
                     /translation="MIKKIYPIFTILLGAAIYAFGLTYFVVPHHLFEGGATGITLITF
                     YLFKIPVSLMNLLINIPLFILAWKIFGAKSLYSSLLGTLALSAWLAFFEHIPLHIDLQ
                     GDLLITALIAGILLGIGLGIIFNAGGTTGGTDILARILNKYTHISIGKLLFILDFCIL
                     MLILLIFKDLRLVSYTLLFDFIVSRVIDLIGEGGYAGKGFMIITKRPDQLAKAINDDL
                     GRGVTFIFGQGYYSKENLKIIYCIVGRNEIVKTKEMIHRIDPQAFITITEAHEILGEG
                     FTFEKE"
     gene            complement(2457..3374)
                     /locus_tag="AC0DU4_001975"
     CDS             complement(2457..3374)
                     /locus_tag="AC0DU4_001975"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003919 - FMN adenylyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HIN4237882.1"
                     /translation="MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAA
                     RKDLLPIVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSSQF
                     ASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKDYFDGEVIIVPPVEDEKG
                     KISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARGRTIGYPTANLVLLDRTYM
                     PADGVYVVDVEIQRQKYRAMASVGKNVTFDGEEARFEVNIFDFNQDIYGETVMVYWLD
                     RIRDMTKFDSVDQLVDQLKADEEVTRNWS"
     gene            3842..3999
                     /locus_tag="AC0DU4_001976"
                     /pseudo
     CDS             3842..3999
                     /locus_tag="AC0DU4_001976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617844.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03943 family putative permease subunit"
BASE COUNT         1346 a          859 c          705 g         1399 t
ORIGIN      
        1 aaaatctata cacacgttac aaagaagatg gatgacaata tactcaactt gctagataat
       61 ttatagtttt gccccttttt tgccccctat acataaaaaa agcctgtcac acaagctcaa
      121 atgcttgata tgacgggctt tttctaaatt cattatttaa cagcgtcttt aagagcttta
      181 ccagctttga atgctggtac tttagaagct gcaattgtca tttctttacc agtttgtggg
      241 ttgcgacctt tacgttctgc acgctcacga acttcaaagt taccaaaacc gatcaattga
      301 actttttcac cagctgcaag atagtcagct actgctgcaa atacagcttc aactgctgct
      361 gctgagtctt tcttagtcaa ttctgtagct tctgctactt tagcgatcaa atcttgtttg
      421 tttgccatgt taatgattcc tccaaataat ttctaattaa caaatataat catatcctaa
      481 aatccctttt aggtcaagtt aaaaacgcta tttcttccca ttttatttat ttttttagga
      541 gtggtaacgt atcaaaatag cccaagcgtt ctcacccgtg tgagtttgaa taatggaacc
      601 cgtttccaaa acagaaattg gcttttcaac ataaacttgt aagctttctt tcatctcttt
      661 tgcccaatca tcactaccag aatatgaaat tccaatctct gctacagcac gttcagaaag
      721 cgatgttatc aactcatcta accatttttt aaatgtttta gttccacgac ctttaaccat
      781 tggctgcaat tcatggtctt tcatttgcat gacaacacgg atattgagaa gggagctcaa
      841 caagccagtt acacggccaa ttcgtccacc tttgacaaga ttttccaaag ttgaaacacc
      901 aatataaagc tctgtatggt ttttaacctc ttctacatga gataaaattg cctccatatc
      961 tttaccttct tgagctaact tcgcagcctc aacaacttgg aatttcaggg cttggtcagt
     1021 gaaggaacta tcaacaacag tcacatctgc agtagatagg ctagcacctt ggcgtgctgc
     1081 ttctaccgta cccgaaagag catgggacat atgaatagca agaatctggc caccatcttt
     1141 gcataggtct tcaaaaatct cagcaaagac acctacaggt ggctgacttg ttttcggaag
     1201 attcttactt tcttgcatca actgaagaaa tttaccttct tctttcaaat ccgcatcaga
     1261 ataaacaaca ttatcaatca ttacagataa tggaacaatt gtaatatcta attgctttac
     1321 tagttcaggt tcaatagtaa cagatgaatc ggttacaatc ttaatttttg tcatagtatc
     1381 aatctttcta ttttaggatt cagattggtt tccttacttc taattatatc aaaaaaaaga
     1441 ttaaaaatcc taatggagtc aatcaaattt tccgtaaaat ttgatataat caacttataa
     1501 gaaaagaggt gtcctatgat taaaaaaatt taccccattt ttaccatttt actaggtgct
     1561 gctatttatg cttttggact gacttatttt gtagttcccc atcatctctt tgaaggaggg
     1621 gcgacaggca ttaccctcat caccttttat ctttttaaaa tccctgtttc cctcatgaac
     1681 ctgctgatta atattcccct tttcatccta gcttggaaga tctttggagc caaatccctc
     1741 tattctagtt tactaggaac cttagctttg tccgcctggt tagctttttt tgagcatatt
     1801 ccccttcata ttgatcttca aggtgattta ctaatcacag cccttatagc gggaatccta
     1861 ttgggaattg gccttggaat tatttttaat gctggaggta caactggcgg aactgatatt
     1921 ctagctcgta ttctcaacaa atacactcat atatccatag gaaaactgct ctttatctta
     1981 gatttttgta ttctcatgtt gattctccta atcttcaagg atttgagatt ggtttcctac
     2041 acgcttttgt ttgattttat tgtttctcgt gttattgatt tgattggtga aggaggatat
     2101 gccggcaaag gctttatgat tatcacaaaa cgtcctgacc aacttgctaa ggcgattaat
     2161 gatgacctcg gaagaggtgt tacttttatt tttggtcaag gctactatag taaagaaaat
     2221 ttgaaaatca tctactgtat tgtcggaaga aatgaaattg tgaaaacgaa ggaaatgatt
     2281 catcgaatcg atcctcaagc ctttataact attacagaag cccatgaaat cctaggagaa
     2341 ggcttcacct ttgaaaaaga ataaaaagag gtaatgtcgt gacctcaaaa gttagactaa
     2401 atcatctatc ttttgggtta cagacaacct cttttttgtt ttatttactc aagctcttaa
     2461 gaccaattcc gagttacttc ttcatcagcc tttaactgat ccactaattg gtcaactgag
     2521 tcaaatttgg tcatatcacg aatgcgatca agccaataaa ccatgacggt ttccccataa
     2581 atatcttgat taaaatcaaa aatattgact tcaaaacgtg cttcttctcc atcaaaggtc
     2641 acatttttcc cgacactagc catagcacga tacttctgtc tttgaatctc aacatcaacg
     2701 acataaacgc catctgctgg catataagta cggtctaaaa gcactaaatt cgctgtcgga
     2761 taaccaattg tacgaccacg agcattacca tgaactacca tacctcttga tggaagcggt
     2821 gcccccaaaa gttttcctgc ttctttcaca tttccatcta aaatagcttg acggatacga
     2881 gttgaactaa tctttccttt ctcatcttct acaggtggaa caatgataac ttctccatca
     2941 aagtaatcct ttaaatcttc tgctgttttt ttgtcagaac caaatgtata atcaaaacct
     3001 gcaacaataa ttttggcatt catagccttg atataagttg caaagaattc ttgtgcagtg
     3061 agactagcga attgactact aaaatcaagg agatataatt cttctacacc ttcgcgcttt
     3121 agttttcttt cacgttcagc agggttcaaa atatgcaaaa acaaatctgg atgataaggc
     3181 tctaaagcga tctttggaga ttcattaaag gtcataacga cgataggtaa taaatccttt
     3241 ctcgcagcct tgttggcaac acgaaataat tcttgatgcc ccttatgtat gccatcaaaa
     3301 tagccgagaa caacgactga atcagatggt gtgccaatat ctttttggtt ttttatagga
     3361 atagtaataa tcataaaata attatatcat agcgatagct atttctggaa cagaaaatct
     3421 gaaatgttgt ttttttcaca tgaagtgtac ctgttttcaa aaagcacttt attctatcgt
     3481 tgcttaacta tgaactttgc aatattcttc tcaaaaactt gtaggacatc ttcaaaattt
     3541 tgcaaggagt gattagactt gttcggtaac cataaagtgt catactatgc ttatgtatga
     3601 aaaagcaatg caactaactc ctgagaactt taaattacta attggtgccg aaaaggtaga
     3661 atttagaatc gaggtacacc tatggctgta aaatttacaa aatgagacaa cttgggcaag
     3721 atgtttgaag aatttcctaa actccctgat ttgaagcaag tcactttccc tgatgacaaa
     3781 aaaagccaaa gcagtaaaga aaaactagat gactgctttc caacaacttc catctagtgt
     3841 gcttcagact gggctatttt tctctccatc tgttagcttg gattctcaga ccgtttcagc
     3901 taaagaatat cttttccctt atcagaagga acggctcaag ccattcagac aagtgaaggg
     3961 acgacaagcc aatatttgaa accagatagc agttcttata gtcaattgaa ataaaatctg
     4021 aagaaatcga gtaggaaact caaatcaatt tttaacagtg ttctattcca gattcatact
     4081 caatgaaaat taaagtgcaa actaggaagt tagccgcagg ctgtacttga gtacggcaag
     4141 gtgaaactga cgtggtttga atttgatttt cgaagagtat caatccacta tacatattaa
     4201 aaagtatggg tatcaaaata aaaaggctct ataatatttg tagtgggtaa atccactata
     4261 gatattatgg agcctatttt gtgtagaaaa aaagtcccat atgacctat
//
LOCUS       DBMVGT010000101         4303 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.101, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000101 DBMVGT010000000
VERSION     DBMVGT010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4303)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4303)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4303
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.101"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..549
                     /locus_tag="AC0DU4_001977"
     CDS             <1..549
                     /locus_tag="AC0DU4_001977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HIN4237883.1"
                     /translation="DHGYSEAIYLEDLEGNGIELYRDKPVSTWDIREDGRIIGVTEAL
                     AAQDIYELGERVEPFILAEGTRMGHIHLSVKDSRKSSQFYQKVLGLEDKFSVPSASWI
                     AAGDYHHHLAVNEWGGKGLASRKQGLPGLAYYVIEVAHKEELLTIVQRAQEVDAPIKW
                     MTSSQLEITDSDGIVTRIRLAR"
     gene            699..956
                     /locus_tag="AC0DU4_001978"
     CDS             699..956
                     /locus_tag="AC0DU4_001978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="HIN4237884.1"
                     /translation="MTNSKYITCLKRSEGQLCGIQKMIEGDRDCADIVTQLTAVRSSV
                     ERVIEMIITENLTECINQPLDDSEAQKERLEKAIRYLIKRK"
     gene            complement(1124..1360)
                     /locus_tag="AC0DU4_001979"
     CDS             complement(1124..1360)
                     /locus_tag="AC0DU4_001979"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237885.1"
                     /translation="MKIKVQTRKLAAGCSKHCFKVVDGTDEVSSKHCFEVVDRTDEVS
                     NHIYGKVKLMWFEEIFEEYKFLHNKTHITKVLMN"
     gene            complement(1414..1647)
                     /locus_tag="AC0DU4_001980"
     CDS             complement(1414..1647)
                     /locus_tag="AC0DU4_001980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001822109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HIN4237886.1"
                     /translation="MDVREAHEFQAGHAPGAKNLPLSTLEQGYKELKPDHEYYVICQG
                     GVRSASTCQFLSSQGLTVTNVEGGMNTWPGQVE"
     gene            complement(1700..1882)
                     /locus_tag="AC0DU4_001981"
                     /pseudo
     CDS             complement(1700..1882)
                     /locus_tag="AC0DU4_001981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691454.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
     gene            1931..2695
                     /locus_tag="AC0DU4_001982"
     CDS             1931..2695
                     /locus_tag="AC0DU4_001982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside phosphorylase"
                     /protein_id="HIN4237887.1"
                     /translation="MIQKHAIPILEFDDNPQAVIMPNHEGLDLQLPKKCVYAFLGEEI
                     DRYAREVGANCVGEFVSATKTYPVYVINYKGEEVCLAQAPVGSAPAAQFMDWLIGYGV
                     EQIISTGTCGVLADIEENAFLVPVRALRDEGASYHYVAPCRYMEMQPEAIAAIEEVLE
                     DRGIPYEEVMTWTTDGFYRETAEKVAYRKEEGCAVVEMECSALAAVAQLRGVLWGELL
                     FTADSLADLDQYDSRDWGSEAFNKALELSLASVHHL"
     gene            3308..>4303
                     /locus_tag="AC0DU4_001983"
     CDS             3308..>4303
                     /locus_tag="AC0DU4_001983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000897732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0006812 - monoatomic cation transport
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="potassium transporter TrkG"
                     /protein_id="HIN4237888.1"
                     /translation="MLFKLSKEKIELGLSRLSPARRIFLSFALVILLGSLLLSLPFVQ
                     VESSRATYFDHLFTAVSAVCVTGLSTLPVAHTYNIWGQIICLLLIQIGGLGLMTFIGV
                     FYIQSKQKLSLRSRATIQDSFSYGETRSLRKFVYSIFLTTFLVESLGAILLSFRLIPQ
                     LGWGRGLFSSIFLAISAFCNAGFDNLGSTSLFAFQTDLLVNLVIAGLIITGGLGFMVW
                     FDLAGHVGRKKKGRLHFHTKLVLLLTIGLLLFGTATTLFLEWNNAGTIGNLPVADKVL
                     VSFFQTVTMRTAGFSTIDYTQAHPVTLLIYILQMFLGGAPGGTAGGLKITTFFVLL"
BASE COUNT         1131 a          793 c         1007 g         1372 t
ORIGIN      
        1 gaccatggtt acagtgaagc tatttacttg gaagatttgg agggaaatgg cattgaactc
       61 tatcgagata agccagtttc cacatgggat attcgagaag atggacgcat tatcggagtg
      121 acggaggctc ttgcggcgca ggacatttat gagttggggg aaagagtaga gccctttatc
      181 ctggcagaag gtacaagaat ggggcatatt catctttccg tcaaggatag tcgaaagtcc
      241 agccagtttt atcaaaaggt gttagggcta gaggataaat tcagtgtgcc tagcgctagt
      301 tggattgcgg ctggagatta ccatcatcat ttagcagtta acgaatgggg aggaaaaggt
      361 ctggcttcgc gtaagcaagg cttaccaggt ttagcctact atgtcatcga agtcgcacat
      421 aaagaagaac tgttaacgat tgtccaacga gcacaagaag ttgacgcacc aatcaaatgg
      481 atgacatcga gccaattgga aatcacagac tcagatggca tcgtgacccg tattcgttta
      541 gcaaggtaaa attaggaatt tctaataagt tataagtatt gctagtttgc tttttgaacg
      601 gtctttggta acagaactgc gtgagctgga tgggtgagaa ttttgacaaa gaagctgatt
      661 agagatataa tgaagaaaaa tcgagcaagg aaaaagaaat gacaaattca aagtatatta
      721 cttgtttgaa acgttcagag ggccagttgt gtgggattca aaagatgatt gaaggagatc
      781 gtgactgtgc tgatattgtg acgcaactga cagcagtgag atctagtgta gagcgcgtga
      841 ttgagatgat aattaccgaa aatcttactg aatgtatcaa tcagccacta gatgattctg
      901 aagctcaaaa ggaacgccta gaaaaggcta tccgatactt gattaaacgg aaataaatga
      961 atgttttgag acgatatgtg caaaggtcta ttaactatta gaatagttta atgtgagtca
     1021 aaagaagttg taaaaaatct ttaaaattaa aaaaacgcat agtatcaggt gttgaatgta
     1081 ctgaccccca aaagttagat tttttctgtc taacttttgg gggtcagttc ataagaacct
     1141 tggtaatatg cgttttatta tgtagaaact tatactcttc gaaaatctct tcaaaccaca
     1201 tcagcttcac cttgccgtag atatggttac tgacttcgtc agttctatcc acaacctcaa
     1261 aacagtgttt tgagctgact tcgtcagttc catccacaac cttaaaacag tgttttgagc
     1321 agcctgcggc taacttccta gtttgcactt taattttcat tgagtattac ttcatcttct
     1381 catgaaattg agtttttgcc cagctcctct tgattattct acttgaccgg gccaagtatt
     1441 cataccacct tctacgttgg taacggtgag gccttgggag ctgagaaatt ggcaggtaga
     1501 tgcagagcgg actcctcctt gacaaataac atagtattca tggtcaggtt tgagttcttt
     1561 gtagccttgc tctaaggtac ttaatggaag atttttggca cctggtgcat gtcctgcttg
     1621 gaattcatgt gcttcacgga catcgataag ttctagattt tcattttagt attttccata
     1681 aaagtcagcc atgctgatac tagtttccat attctactcc ttctgggtta gccattttgt
     1741 atagtgaata agcgccgtca aggttttgga cggtaaatcc tgcttgcttg aggataggct
     1801 ctgcgatata gctgcgcaaa ccactgtggc agctgacgat gtaggcttgt tttttgtcca
     1861 gttcatcagc ttcctccttg acactttgtc agtttttgat acaatagtac aaaattagag
     1921 gaggtgggct atgattcaga aacatgcgat tcccatttta gagtttgatg ataatcctca
     1981 ggcggttatc atgcccaatc acgaggggtt ggatttgcag ttgccaaaga agtgtgtcta
     2041 tgctttttta ggtgaggaga ttgaccgcta tgcgagggaa gtaggggcga actgtgttgg
     2101 cgaattcgtt tctgctacca agacctatcc agtctatgtc atcaactaca agggtgagga
     2161 ggtctgtctg gctcaggctc ctgttggctc cgctccagca gcccagttta tggattggtt
     2221 gattggctat ggtgtggagc agattatctc tactgggacc tgtggtgtcc tagctgatat
     2281 agaggaaaat gcctttctag tccctgttcg cgctttgcga gatgagggag ccagttacca
     2341 ctatgtggca ccttgtcgtt atatggaaat gcagccagag gctattgctg ctattgagga
     2401 agttttggaa gacagaggga ttccttatga agaagtcatg acctggacga cagacggttt
     2461 ttaccgagaa acggctgaaa aggtggctta tcgtaaggaa gaaggctgtg ctgttgtgga
     2521 gatggagtgt tctgctcttg cggcagtagc tcaattgcgt ggggttctct ggggtgaatt
     2581 gttgttcaca gcagattctc tagcggactt ggaccagtac gacagtcgtg actggggctc
     2641 ggaagctttt aataaggcgc tagaactgag tttagcaagt gttcaccacc tttagttgta
     2701 caggcaaagg atttgtttta tcataaaatg tctagctcat acttttcaaa aatatgttta
     2761 aacgaggtca ccttcctctt gtcctaggca tgttgaggtt gggaaaaatc tttaaaatca
     2821 gaaaaacgta tcatatcagg tgatgaaaat tttgatacta tgcgttttat gttggtaaga
     2881 tttagagtga gatgaaatga tactcttcga aaatctcttc aaaccaggtc agcttcacct
     2941 tgccgtaggt atatgttact gacttcgtca gtcttatccg gcaacctcaa aacggtgttt
     3001 tgagctgact tcgtcagttc tatccacaac ctcaaaacag tgttttgagc aacctgtgac
     3061 tagctttcta agcgatgcct tggttctcat tgcctataat caaaaagaga aattttctcc
     3121 tgaaaagcat atagagtagc tggcgttaaa agctcctgtc ttgctttttt gacctatagt
     3181 cacatctatc aagtattgtt cttgcctaag ctatcaataa aaaggtggca ttttttaggc
     3241 ttggtgttag tgaattttgc cttatcctat ctaagtcatt tcgagctttt tatggtacaa
     3301 tggaaacatg ttattcaaat tatctaagga aaaaatagag ctaggcttat ctcgtttatc
     3361 gccagcccgt cgtatttttt tgagttttgc cttggtcatt ttactaggct ctcttctttt
     3421 gagcttgccc tttgtccaag ttgaaagctc acgagcgact tattttgatc atcttttcac
     3481 tgctgtctct gcagtctgtg tgacaggtct ctcaaccctt ccagtagctc acacctataa
     3541 tatctggggc caaataatct gtttgctctt gattcagatc ggtggtctag ggctcatgac
     3601 ttttattggg gttttctata tccagagcaa gcaaaagctt agtcttcgta gccgtgcaac
     3661 tattcaggat agttttagtt atggagaaac tcgatctttg agaaagtttg tctattctat
     3721 ttttctcacg acctttttgg ttgagagctt gggagctatt ttgcttagtt ttcgccttat
     3781 tcctcaactt ggctggggac gtggtctttt tagttccatt tttctagcga tctcagcctt
     3841 ctgtaatgcc ggttttgata atttagggag caccagttta tttgcttttc agaccgattt
     3901 actggtcaat ctggtgattg caggcttgat tattacaggc ggccttggtt ttatggtctg
     3961 gtttgatttg gctggtcatg taggaagaaa gaaaaaagga cgtctgcact ttcatacgaa
     4021 gcttgtacta ttgttgacta taggtttgtt gttatttgga acggcaacta ctctctttct
     4081 tgagtggaac aatgctggaa cgattggcaa tctccctgtt gccgataagg ttttagttag
     4141 cttttttcaa acagtgacga tgcgaacagc tggcttttct acgatagatt atactcaggc
     4201 tcatcctgtg actcttttga tttatatctt acagatgttt ctaggtgggg cacctggagg
     4261 aacagctggg ggactcaaga ttacgacatt ttttgtcctc ttg
//
LOCUS       DBMVGT010000102         4176 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.102, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000102 DBMVGT010000000
VERSION     DBMVGT010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4176)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4176)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4176
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.102"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..126)
                     /locus_tag="AC0DU4_001984"
     CDS             complement(<1..126)
                     /locus_tag="AC0DU4_001984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 transposase-related protein"
                     /protein_id="HIN4237889.1"
                     /translation="MAYSIDFRKKVLSYCERTGSITEASHVFQISRNTIYGWLKLK"
     gene            194..349
                     /locus_tag="AC0DU4_001985"
                     /pseudo
     CDS             194..349
                     /locus_tag="AC0DU4_001985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol/lipid kinase family protein"
     gene            549..3824
                     /gene="rexB"
                     /locus_tag="AC0DU4_001986"
     CDS             549..3824
                     /gene="rexB"
                     /locus_tag="AC0DU4_001986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004518 - nuclease activity [Evidence
                     IEA];
                     GO_process: GO:0000724 - double-strand break repair via
                     homologous recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent nuclease subunit B"
                     /protein_id="HIN4237890.1"
                     /translation="MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKER
                     AVLECLSQQASFSITVTRFAQMARYLVLNDLPVKTTLDDIGLGLAFYKCLAELDPKDL
                     RVYGAIKQDPQLIQQLIELYHEMTKSQMNFLDLENLTDEDKRADLLLIFEKVTAYLNQ
                     GQLAQGSQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVI
                     GAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLE
                     SSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILL
                     GDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYCFRQEDLINLL
                     RTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQIFTKSHHGKFNLERLNVLRLRILAP
                     LETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVL
                     EQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYA
                     IGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSA
                     RKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSL
                     VAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDQQGLENPAIPISPSSKTLAKDTLQALY
                     PAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQL
                     PNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIE
                     TIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPH
                     FFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKY
                     QGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYT
                     ENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREE
                     LNR"
     gene            3821..>4176
                     /locus_tag="AC0DU4_001987"
     CDS             3821..>4176
                     /locus_tag="AC0DU4_001987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="HIN4237891.1"
                     /translation="MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNIL
                     VSASAGSGKTFVMAERILDQLARGVEISQLFISTFTVKAANELKERLEKKISKKIQET
                     DDVDLKQHLGRQLADLP"
BASE COUNT         1246 a          850 c          896 g         1184 t
ORIGIN      
        1 ttttagcttt aaccagccat aaatggtatt acgtgagatt tggaaaacgt gtgatgcttc
       61 tgttatacta cctgttcgct cacaataaga gagaactttt ttacgaaaat ctattgaata
      121 tgccataaga agattatacc acattgtgtc ctatttttgg ttcattttac tatagttcaa
      181 tcattctatc aagaatattg aatatataaa ggcacgtaat attaaaactt cttctgatat
      241 cgaattagag tccgatgttg atggcgataa atcagacaat ctacccgtcg acattaagac
      301 actgggacaa cacattgaag tgtattccgt acctaagaaa caatcataaa actcaaagcc
      361 ttgttaccga ggctttttta ttatatgatt ttcagtggcc agacttattc tatctaatac
      421 aagtaaagct aagtatttaa gatttagcag atgatgaaga aaagaaagga tggcctaaat
      481 attttaacag atttacgagg ctaatcatgg tataatatag ggtgatgaaa aattccaacg
      541 aggctgagat gaaattactt tatactgata ttcgaacttc tttgacagaa attctaacaa
      601 gagaggcaga agagctagtt gcagctggca agcgggtctt ctacattgcc cccaactctc
      661 tttcttttga aaaggaacgc gccgtgctgg aatgcttgtc ccagcaggct tctttttcga
      721 ttaccgtcac gcgctttgct caaatggctc gttatctggt cttgaatgat ttaccagtta
      781 aaactactct tgatgatatc ggtcttgggt tggcctttta caaatgcctt gccgaactcg
      841 atcccaagga cttgcgtgtt tatggagcta ttaagcagga tcctcaattg atccagcagt
      901 taattgagct ttaccatgag atgaccaaat ctcagatgaa ttttttggac ttggagaatt
      961 taacagatga ggataagagg gcggatttac tcttgatttt tgagaaagta acagcctatc
     1021 ttaatcaagg tcagttagcc cagggaagtc agttgtccca tttgattgag gctattgaga
     1081 atgacaaggt aagtagtgat tttaatcaaa tcgccttggt cattgacggc tttactcgtt
     1141 tttctgctga ggaagagcgg gttgtggact tacttcacgg caaaggtgtt gagattgtta
     1201 tcggggctta tgctagtaag aaagcctata ccagtccttt tagcgagggc aatctctacc
     1261 aagccagcgt aaaatttctc catcatctgg cttctaaata ccaaacgccc gctcaggact
     1321 gttctcaaac tcatgagaag atggatagtt ttgacaaggc ctctcgtttg ttggagtctt
     1381 cttatgactt ttcagaactc gctttggatg tcgatgagaa agaccgtgaa aatttacaaa
     1441 tctggtcttg tttgacgcaa aaggaggagt tggagctagt agcccgtagc attcgtcaga
     1501 aattacatga gaactcagac ctgagctaca agcattttcg tattctcttg ggggatgtag
     1561 cttcttacca gttatctctc aaaaccattt ttgaccagta tcagattcct ttttatcttg
     1621 gtagaagcga agccatggct catcatccct tgactcagtt tgtcgagtct attttagctt
     1681 taaaacgtta ctgttttcgt caggaggatt tgattaatct tcttagaact gacttgtata
     1741 ctgacctcag tcagtctgat attgatgctt ttgagcaata tatccgctat cttggtatca
     1801 atggcttgcc agcctttcag caaatcttca ccaaatccca ccatggaaaa tttaatcttg
     1861 agcgtttgaa tgtcctccgc ctgagaattt tagcacctct tgaaaccctc tttgccagcc
     1921 gaaaacaaaa ggctgaaaac ctcctacaaa aatggagtgt ctttctaaaa gaaggagctg
     1981 tgaccaagca gttacaagat ttgacaacca ctttggaagc tgtagaacag gaaagacaag
     2041 ccgaagtttg gaaggctttc tgccatgttt tagaacaatt tgcgactgtt tttgctggtt
     2101 cacaggttag tctggaagac ttcctagcct tgctccattc tggaatgagt ttgtcccaat
     2161 accgtaccat tccagcaaca gtggacactg ttctggtgca gagttacgat ttgattgcac
     2221 cattgactgc tgactttgtc tatgctattg gactaactca ggacaattta ccaaaaattt
     2281 ctcaaaacac cagtcttctg acagatgaag aaaggcaaaa tctaaaccaa gcgaccgaag
     2341 aaggcgttca attactgatt gccagcagtg aaaatctcaa gaaaaatcgc tacactatgc
     2401 tttccttagt caattctgct cgtaagcagt tgttcttgtc ggctccaagc ctttttaacg
     2461 aaagtgaaag taaggaatct gcctatcttc aagagttgat ccattttgga tttaggcgga
     2521 gagagaagag gatgaatcac aaaggactgt ctaaggagga tatggggtcc tatcacagtc
     2581 ttttgtctag tctggttgcc tatcaccagc agggtgagat gagcgatact gagcaagatt
     2641 tgacttttgt caaggttctg tcgcgtgtca taggtaaaaa actagatcag caaggtctgg
     2701 aaaatccagc catcccaatc agtccaagca gcaagacctt agccaaggac accttgcaag
     2761 ctctctatcc tgccaaacag gagttttacc tgtctacgtc gggtttgaca gagttttatc
     2821 gcaatgaata cagttatttc ctacgctacg ttttaggctt gcaggaggaa ttacgtttgc
     2881 gtcctgatgc ccgtagtcac gggaatttct tgcatcgtat ctttgaacgc gccttgcagt
     2941 tgcctaatga agattccttt gaccaacgtc tagaacaagc tattcaagaa accagtcaag
     3001 aacgcgaatt tgaagctatt tatcaagaaa gtttggaagc ccagtttacc aaggaagttt
     3061 tgcttgatgt tgcacggaca actggacata ttctccgaca caatccagcc atcgaaacaa
     3121 tcaaagaaga agcaaatttt ggtggaaaag accaagcctt tattcaatta gacaatggac
     3181 gcagtgtctt tgtacgaggc aaggtggacc ggattgaccg tttgaaagct aatggagcga
     3241 taggagtagt agactacaaa tccagtctga ctcagttcca gtttcctcat ttctttaatg
     3301 ggctcaattc tcagttacca acctatcttg ctgccctaaa aagagaaggg gagcagaact
     3361 ttttcggcgc catgtacttg gaaatggctg aacctgtcca atctctgatg gcggtaaaaa
     3421 gtctggcagg agcagtggta gaagccagca aatctatgaa ataccaaggg ctcttcttgg
     3481 aaaaagaaag cagttattta ggcgaatttt ataacaaaaa caaggcgaat caactgacag
     3541 atgaggaatt tcagctccta ctggactaca atgcctatct ttacaagaaa gctgctgaga
     3601 agattttagc aggccggttc gccatcaatc cttatactga aaatggcaga agcattgccc
     3661 catacgtcca gcaacatcag gctattacag gctttgaagc caattaccat ctgggccaag
     3721 cccgtttcct agaaaagttg gacctagctg atggcaagcg tctggtcgga gaaaaactca
     3781 agcaagcttg gcttgaaaaa ataagagagg agttgaatcg atgaagctta ttcccttttt
     3841 aagtgaggag gagattcaaa aactgcaaga agcagaagca aattcgagca aggaacagaa
     3901 gaaaactgcc gagcaaatcg aagctatcta cacttctggc cagaatatcc tggtctcagc
     3961 atcggctggt tctggaaaga cctttgtcat ggcagagcgc attctggacc aattggcgcg
     4021 tggtgtcgaa atttctcaac tctttatctc aacctttacc gtcaaggctg caaatgaact
     4081 taaagaacgt ttagagaaaa aaatcagcaa gaaaatccaa gaaacagatg atgtcgacct
     4141 caaacaacac ttgggacgcc agttggcaga cctacc
//
LOCUS       DBMVGT010000103         4134 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.103, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000103 DBMVGT010000000
VERSION     DBMVGT010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4134)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4134)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4134
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.103"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..588
                     /locus_tag="AC0DU4_001988"
     CDS             <1..588
                     /locus_tag="AC0DU4_001988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HIN4237892.1"
                     /translation="EELNPVEEVASAAAAPVAQAAIPEGTVIGDGKLKINLARLDTRL
                     LHGQVATAWTPDSKANRIIVASDNVAKDDLRKELIKQAAPGNVKANVVPIQKLIEISK
                     DPRFGETHALILFETPQDALRAIEGGVPIKTLNVGSMAHSTGKTLVNTVLSMDKEDVA
                     TFEKMRDLGVEFDVRKVPNDSKKDLFDLINKANVK"
     gene            616..1419
                     /locus_tag="AC0DU4_001989"
     CDS             616..1419
                     /locus_tag="AC0DU4_001989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0034219 - carbohydrate transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter subunit
                     IIC"
                     /protein_id="HIN4237893.1"
                     /translation="MSIISMVLVVVVAFFAGLEGILDQFQFHQPLVACTLIGLVTGHL
                     EAGIILGGSLQMIALGWSNIGAAIAPDAALASVAAAIIMVLGGDFTKTGIGVAQAVAI
                     PLAVAGLFLTMIVRTISVGLVHTADAAAKKGDFGAVERAHFIALLFQGLRIALPAALL
                     LMVPTETVQSILSAMPDWLKDGMAIGGGMVVAVGYAMVINMMATREVWPFFALGFVLA
                     AVSDITLIGFGAIGVAIALIYLHLSKTGGNGGGGAATSNDPIGDILEDY"
     gene            1443..2354
                     /locus_tag="AC0DU4_001990"
     CDS             1443..2354
                     /locus_tag="AC0DU4_001990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:1902495 - transmembrane transporter
                     complex [Evidence IEA];
                     GO_function: GO:0016301 - kinase activity [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA];
                     GO_process: GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="HIN4237894.1"
                     /translation="MTEKLQLTKSDRKKVWWRSTFLQGSWNFERMQNLGWAYTLIPAI
                     KKLYTKKEDQIAALERHLEFFNTHPYVAAPVMGVTLALEEERANGVEIDDAAIQGVKI
                     GMMGPLAGIGDPVFWFTVRPILGSLGASLALTGNILGPLLFFVAWNLIRMSFLWYVQE
                     IGYKAGSEITKDMSGGILQDITKGASILGMFILAVLVQRWVNIKFAFDVSKVQLDEKA
                     YIHWDKLPEGSKGIQEAFAQVGQGLSQTPEKVTTFQQNLDMLIPGLSGLLLTLLCMYL
                     LKKKVSPITIILALFAVGIVAHVLHIM"
     gene            complement(2410..3744)
                     /gene="pepC"
                     /locus_tag="AC0DU4_001991"
     CDS             complement(2410..3744)
                     /gene="pepC"
                     /locus_tag="AC0DU4_001991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000991632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase C"
                     /protein_id="HIN4237895.1"
                     /translation="MNAIQESFTDKLFANYEANVKYQAIENAASHNGIFAALERRQSH
                     VDNTPVFSLDLTKDKVTNQKASGRCWMFAALNTFRHKLISQYKLENFELSQAHTFFWD
                     KYEKSNWFLEQVIATSDQELTSRKVSFLLQTPQQDGGQWDMVVSLFEKYGVVPKSVYP
                     ESVSSSSSRELNAILNKLLRQDAQILRDLLVSGADQATVQAKKEDLLQEIFNFLAMSL
                     GLPPRKFDFAYRDKDNNYKSEKGITPQEFYKKYVNLPLEDYVSVINAPTADKPYGKSY
                     TVEMLGNVVGSRAVRYINVPMERLKELAIAQMQAGETVWFGSDVGQLSNRKAGILATD
                     VYDFESSMDIKLTQDKAGRLDYSESLMTHAMVLTGVDLDENGKSTKWKVENSWGDKVG
                     TDGYFVASDAWMDEYTYQIVVRKELLTAEEQAAYGAEPIVLAPWDPMGALAE"
     gene            complement(3961..>4134)
                     /locus_tag="AC0DU4_001992"
     CDS             complement(3961..>4134)
                     /locus_tag="AC0DU4_001992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA pseudouridine(516) synthase"
                     /protein_id="HIN4237896.1"
                     /translation="AEGKFHQIKRMVGYCGKEVVDLQRLTMGTLVLDENLERGEWRRL
                     TKEELEILRANII"
BASE COUNT         1103 a          923 c          851 g         1257 t
ORIGIN      
        1 gaagagctaa atccagttga agaagttgca agcgctgcag ctgctccagt tgcccaagct
       61 gctatcccag aaggaactgt tatcggagac ggtaaattga aaatcaatct tgcccgtctt
      121 gacacacgtc tacttcacgg tcaggttgca actgcttgga ctccagattc aaaagcaaat
      181 cgtatcatcg ttgcttcaga taacgtggct aaagacgacc ttcgtaaaga attgattaaa
      241 caagcagctc caggtaatgt caaggctaac gtggttccaa ttcaaaaact gattgagatt
      301 tcaaaagacc cacgttttgg agaaacacat gcccttatct tgtttgaaac acctcaagat
      361 gcccttcgtg ccatcgaagg cggcgtgcca atcaagactc ttaacgttgg ttctatggct
      421 cactcaacag gtaaaacatt ggtcaatacc gttttgtcta tggacaaaga agatgttgcg
      481 acatttgaaa aaatgcgtga cttgggtgtt gaatttgatg tccgtaaagt accaaatgat
      541 tctaaaaaag atttgtttga cttgattaac aaagccaatg tcaaataagc cattatttat
      601 gaaaggattt taaacatgtc tattatttct atggttttag tagtcgttgt agccttcttt
      661 gcaggtcttg aaggcatcct cgaccagttc caatttcacc aaccacttgt agcctgtacc
      721 cttattgggc ttgtaacagg tcacttggaa gcagggatta tcctcggtgg atcgcttcaa
      781 atgattgccc ttggttggtc aaatatcggt gctgctatcg ctcctgatgc tgcacttgct
      841 tctgtcgctg ctgccattat catggttctt ggtggtgact ttaccaagac tggtatcggt
      901 gttgcccaag cggttgctat ccctcttgcc gtagctggac ttttcttgac aatgattgtt
      961 cgtacaattt cagttggttt ggttcatact gcagatgctg ccgctaaaaa aggtgacttc
     1021 ggcgctgtgg agcgtgcgca tttcattgcg ctactcttcc aaggacttcg tatcgcgctt
     1081 cctgcagctc ttctccttat ggtaccaact gaaactgtac aaagtatcct tagtgccatg
     1141 ccagactggc tcaaagatgg tatggctatc ggtggtggta tggtcgttgc cgttggttac
     1201 gccatggtta tcaacatgat ggcaactcgt gaagtatggc cattcttcgc tcttggtttc
     1261 gttctcgctg ctgtgtcaga tattactcta atcggattcg gtgctatcgg tgttgctatc
     1321 gctcttatct accttcacct ttctaaaact ggtggaaatg gtggcggagg agccgcaact
     1381 tctaacgacc caatcggcga tatcctagaa gactactaag ataagaaagg actgaaaaca
     1441 tcatgactga aaaacttcaa ttaactaaat cagatcgtaa aaaagtttgg tggcgttcaa
     1501 ccttcttaca agggtcttgg aactttgaac ggatgcaaaa cttgggctgg gcttatacac
     1561 tcattccagc tatcaaaaaa ctctatacta aaaaagaaga tcaaatcgct gctcttgagc
     1621 gtcaccttga gttcttcaac actcatccat acgtagctgc tccagtcatg ggggttactc
     1681 ttgcgcttga agaagaacgt gctaacggtg tggaaatcga tgacgctgct atccaagggg
     1741 tcaaaatcgg tatgatggga cctcttgctg gtatcggtga cccagtattc tggtttacag
     1801 tacgcccaat ccttggatct ctcggtgctt cacttgccct tactggcaat atcttgggtc
     1861 cactcctctt ctttgttgca tggaacttga ttcgtatgtc attcttgtgg tatgttcaag
     1921 agattggata caaggctgga tcagaaatca ctaaagatat gtctggtggt atccttcaag
     1981 atatcactaa aggagcttct atccttggga tgttcattct tgctgtcctt gttcaacgct
     2041 gggtaaatat taaatttgct ttcgatgttt ctaaagttca actagatgaa aaggcttata
     2101 tccattggga taaattgcca gaagggtcta aaggtatcca agaagcattc gcacaagtag
     2161 gacaaggatt gtctcaaact cctgaaaaag ttactacttt ccaacaaaac ttggatatgt
     2221 tgattcctgg attatcagga ctactcctta ctttactttg catgtactta cttaagaaaa
     2281 aagtatctcc aatcactatt atccttgccc tcttcgcagt gggtattgtg gcacatgttc
     2341 ttcacatcat gtaatcaagc aactaaaaag gaaccaggtt ctaaaatctg attccttttt
     2401 tctatgcttt tattcagcca aggctcccat tggatcccat ggtgcaagta caattggttc
     2461 tgctccatag gcagcttgtt cttctgctgt cagcaattcc ttacgaacaa cgatttggta
     2521 tgtgtattcg tccatccaag cgtctgaggc aacaaagtaa ccatctgtac cgaccttgtc
     2581 tccccatgag ttttcaacct tccacttggt tgatttacca ttttcgtcca agtcaacacc
     2641 tgtcaagacc atggcgtggg tcatcaagct ttcgctatag tccaaacgtc cagccttgtc
     2701 ttgagtaagt ttaatgtcca tgcttgattc aaagtcataa acatctgtcg caaggatgcc
     2761 agccttacgg ttactgagct ggccgacatc agaaccaaac caaacagtct cacctgcttg
     2821 catttgggca atcgccaatt ctttcaagcg ctccattgga acgttgatgt aacgaactgc
     2881 acggctacca accacattcc ccaacatctc aactgtgtaa gattttccgt aaggtttatc
     2941 agcagttgga gcattgataa cagaaacgta gtcttctaaa ggaagattga catatttctt
     3001 gtaaaactct tgtggtgtga ttcctttttc acttttgtag ttgttatctt tatcgcgata
     3061 agcaaagtca aacttgcgtg gtggaagtcc taatgacata gcaagaaagt taaagatttc
     3121 ttgcaagagg tcttctttct tagcttgaac agtcgcttga tctgcaccag aaacaagcaa
     3181 gtcacgcaag atttgagcat cttgacgaag caatttatta aggatcgcat ttagctcacg
     3241 actgctgcta gatgaaacag actcaggata aactgactta ggcacgacac cgtatttttc
     3301 aaagagggaa acgaccatat cccattgacc accatcttgt tgaggtgttt ggagtaagaa
     3361 gctaaccttg cggctagtca attcttggtc tgaagtcgca atgacttgct ccaagaacca
     3421 gtttgatttc tcatacttat cccagaagaa agtgtgggct tgtgacaact caaagttctc
     3481 caatttgtat tgcgagatga gtttgtggcg gaaggtgttg agagccgcaa acatccagca
     3541 acgaccagac gctttctggt tagtgacctt gtccttggtt aaatccaatg agaaaacagg
     3601 tgtgttgtct acatggcttt ggcgacgttc cagagctgca aaaattccgt tgtggctagc
     3661 agcattttca atcgcttggt attttacatt tgcttcatag ttggcaaata gtttatcagt
     3721 aaatgattct tgaatcgcgt tcatagattc ctccttttat tctacagtct attataactc
     3781 ttttcacaaa ggaagcaact aaaaaacata aaaggtaagg acattctccc tcaccttttt
     3841 cgaatatata ctcttcgaaa atctcttcaa accacgtcaa cgtcgccttg ccgtactcaa
     3901 gtacagcctg cggctagttt cctagtttgc tctttgattt tcattgagta ttaaactaaa
     3961 ttaaataata ttagcgcgga gaatttctaa ttcttccttg gtcaagcgac gccattcccc
     4021 tcgttccagg ttctcatcta atactaaagt tcccatagtc aatcgttgca agtccaccac
     4081 ttccttgcca cagtagccca ccatacgctt gatctgatga aacttccctt ctgc
//
LOCUS       DBMVGT010000104         4044 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.104, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000104 DBMVGT010000000
VERSION     DBMVGT010000104.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 4044)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4044)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4044
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.104"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..746)
                     /gene="comA"
                     /locus_tag="AC0DU4_001993"
     CDS             complement(<1..746)
                     /gene="comA"
                     /locus_tag="AC0DU4_001993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="HIN4237897.1"
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKT
                     TMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTG
                     QDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
                     LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIL
                     QQILSYAQEYLLLVLGQRLSIDVILSYIKHV"
     gene            complement(1333..1458)
                     /locus_tag="AC0DU4_001994"
     CDS             complement(1333..1458)
                     /locus_tag="AC0DU4_001994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="HIN4237898.1"
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSEKKTEKSVKK"
     gene            complement(1461..1691)
                     /gene="blpU"
                     /locus_tag="AC0DU4_001995"
     CDS             complement(1461..1691)
                     /gene="blpU"
                     /locus_tag="AC0DU4_001995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="HIN4237899.1"
                     /translation="MNTKKMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAARGLQ
                     LGIKTRTWQGAATGAAGGAILGGVAYAATCWW"
     gene            complement(1894..2193)
                     /locus_tag="AC0DU4_001996"
                     /pseudo
     CDS             complement(1894..2193)
                     /locus_tag="AC0DU4_001996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            complement(2230..2463)
                     /locus_tag="AC0DU4_001997"
     CDS             complement(2230..2463)
                     /locus_tag="AC0DU4_001997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HIN4237900.1"
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEF
                     ILTLEDEFSIEISDEEIDQLQSVGDVVKIIQGK"
     gene            complement(2469..3461)
                     /gene="plsX"
                     /locus_tag="AC0DU4_001998"
     CDS             complement(2469..3461)
                     /gene="plsX"
                     /locus_tag="AC0DU4_001998"
                     /EC_number="2.3.1.274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA];
                     GO_process: GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HIN4237901.1"
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIK
                     QYLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTG
                     ALLAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSF
                     YAKNVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVA
                     DVVVADGFTGNAVLKSIEGTAMGIVGLLKTAITGGGLRAKLGALLLKDSLSGLKKQLN
                     YSDVGGAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            complement(3458..>4044)
                     /gene="recO"
                     /locus_tag="AC0DU4_001999"
     CDS             complement(3458..>4044)
                     /gene="recO"
                     /locus_tag="AC0DU4_001999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HIN4237902.1"
                     /translation="NDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADASLQDN
                     QQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVGQAFD
                     FSFKYGACLCPEHYHEDKRRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQELRQF
                     MDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
BASE COUNT         1181 a          964 c          696 g         1203 t
ORIGIN      
        1 acatgcttga tataggacaa aatcacgtca atcgacaagc gttgccccaa aacaagcaag
       61 agatactcct gagcgtaaga caagatttgc tggaggatgt agacgatgac tagcccaata
      121 gaaataatcc ctagtgtcga acgcatctga tctggcacat aggtatcaat gatagactgc
      181 agataataag aacccacaat gttaatcacg gttaccaaga gtgttgccaa aacgatattg
      241 gcaatcaagc cacgctgctt cactaatata gggataaaag agagcagacc atttttttgt
      301 tccttataag gcttatagtc tggactaggt gccataaaaa gagtcactcc tgtccattct
      361 tcctcaaaac gctcacgtgg cagtttagtc aacttcaccc cgggatctgg atcggcaata
      421 tgaatgctat ccttatcctg cccagtcacc acatagtagt ggagcaattt cccttcctta
      481 agcacatggg caacaaaagg aaaagtcaaa tccggcaagt caaaaagcgt catatccgcc
      541 ttaatggctc gcgtctcaaa accaatctcc tctgccacct tgaccaagcc caaagccgtc
      601 gtcccatcca tggtcgtctt agccaattct cgcaagtgag ccaaaaaata ataactacca
      661 tagtagccaa aaaccatggc taatgaagct acaccgcagt ccatctgatc cacttgcgga
      721 cgatagtgac gtttcccaaa tttcatattc atctcctttt ccctaatact caatgaaaat
      781 caaagagcaa actaggaaac tagccgcagg ctgctcaaaa cactgttttg aggttgtaga
      841 taggactgac gaagtcagtc acatatatac ggcaaggcga cgttgacgtg gtttgaattt
      901 gattttcgaa gagtataaac tcatctgata acaactatct taccccaatc actaaacaaa
      961 aactggactt ccttcccaaa tgagcctatc tccctcccaa ctgcactttt tggataaaaa
     1021 aataggcaga acaagagtcc tgcccactaa aaatatgcta ttgaaaggaa attgattttt
     1081 tactgtcacc ctaggcaagc ttgaaacaaa taaatcattg atagtaacac ttacgacatc
     1141 ctatttatta cttcaatttc taatgtctct gctatttcta agctacctct ggtatgatct
     1201 attcctagtc agaatagata acaccgttct aaattacgat tcatagttac tccttttttg
     1261 actcgttact ataagactcc tctttacatg cgcaaaataa ttttgattca gattcatcat
     1321 ttatagtttt gattattttt taacagattt ttctgttttc ttctccgaag actttaaaaa
     1381 tttttttcta attaaatcat ccatataagg accaaatata ccaactacta aaccaataat
     1441 aaaactttta aaatccataa ttaccaccaa catgtcgctg cataggccac acctccaagt
     1501 atagctcctc ccgcagcacc agttgctgca ccttgccatg ttcttgtttt aattcctagc
     1561 tgaagacctc gtgctgctcc tcctccaaca cctgctttgg caaaatctcc ccaattgcat
     1621 ccgccacctt caacgcaagc aagcatctca gtatccataa tttcaaattg tgacatcttt
     1681 tttgtattca taacgaatac ctctttttta tttttaatat ttgtcttgtt acaaacttga
     1741 caagtttagt ataacagtat ctattaattt ttttcattca aatcttgaat tggcatcgaa
     1801 acgtcttgaa ttagcttttt tgtttcaaaa tcatctctat ttttaaaaaa gatgttttct
     1861 aatcactttt ttactattag acttcctgca aaactagaat cctagttcat gattgataat
     1921 accagcaatc aaattcattc gtaatccgaa gcgtttacga tgatttcgat aggttgttga
     1981 aaacatttta aacgttttta ctttggcaaa gatgttctca accttgcttc tctccttaga
     2041 tagcgcatgg ttacaggctt tatcttcaac tgttagcggc ttgagtttgc tggatttacg
     2101 tggagtttgt gcttgaggat atatcttcat gagcccttga taaccactgt cagccaagat
     2161 tttaccagct tgtccaatat ttctcatttc taaaaaccat ctacttccgt tgacttggaa
     2221 ctccgattgc tattttcctt gaatgatttt aaccacatct cctacacttt ggagttggtc
     2281 aatttcctca tcgctgattt cgatactaaa ttcatcttcc agagtcaaga taaactccat
     2341 caagtcaaca gaatccgcat ccaaatcgtc tttcagactc aaggattctg tcacgacaaa
     2401 gtcctctccc tgtcgctctt ggataatggt cacaatacgg tcaaaaattt ctttttctgt
     2461 catctctttt attctcctga aaattcacgc gcagtctggg caaccacgtc tgtttctagc
     2521 atggtacgaa tctgacgaat cgtactataa acagccttgg catcgcttga gccatgagtc
     2581 ttgacaacag gtgccttaac accaaacaag accgctccac caacatctga ataattgagc
     2641 tgttttttca aaccactgag gctgtccttg agaaggaggg cacctagttt cgctcgaaga
     2701 ccaccacctg taatagctgt cttgagcaag cccacgattc ccatagctgt cccttcgatg
     2761 gatttgagca cagcgtttcc cgtgaaacca tctgccacaa caacatctgc aacgccattc
     2821 atcaaatcac gcgcttccac gtttccgata aagttcaaac tttcatcagc cgccagtaat
     2881 tcataagttt ccttacgaag cgggtcgccc ttgctactct ctgttccgtt gttgagcaaa
     2941 ccaacgcgtg gttgcgcaat gccacggaca tttttagcat agaaggaacc tagaaccgca
     3001 tattgatgga ggtgctgggc tgtattttct gcattggcac caaggtctag catgtcaaaa
     3061 ccttttccat caacggtagg caaggtagac atgagtccag gacggtcgat attcttgata
     3121 cgacccacga tgaagaatcc tgctgccaac aaggcacctg tattcccagc cgaaaggaca
     3181 gcgtctgctt caccatcttt gacagccttg gctgccaata ccatactggc atttttctta
     3241 ttcctaatag ctctcgtagg ttcatcatcc gaatcaatct tctcatccgt atggataatg
     3301 ctgacgcgct ctgtcgctgt cagatattgc ttgattttag cttcatctcc gtaaagttga
     3361 acctcgatat ctgaaaagtc agatagggct tgattgacac cctcaacaat ggcctgaggt
     3421 gcgtaatcgc cccccatggc atctactgcg atttttttca tttcttttcc tcttttagta
     3481 attgtcccca gtctgctagg gaatcaataa atttctttga ttttaggtga atcccaacgt
     3541 actcttcata taattgatcc ataaattggc gtagctcttg cttgattcca ggcttgagcg
     3601 aaatggtctc caaagtctca aaatcaatag cttgaaattg attgagcaga taggggatat
     3661 tgggattgag atgacaacgt ctcttatcct catgataatg ctctggacag aggcaggctc
     3721 catatttgaa agaaaagtca aaagcctgac caacccgatg gcagaagaca cactcattaa
     3781 aattgaggct gattccaaat cgagtcaaaa tttgaatttc aaaaatattg gtcaaaacct
     3841 gataatccaa gcctgcttcc atcaactcca aagtcttttg caaaaaagca aacaagggag
     3901 catcctgctg attgtcctgc aaactagcat ctgcaagagc tgccacatag gtcgcatagg
     3961 ccatgacaaa gaggtcacta ttaatcttgg gaaaagtcat gacctcatga tagtcttcga
     4021 tgtaactgag tccgtcatca ttga
//
LOCUS       DBMVGT010000105         3862 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.105, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000105 DBMVGT010000000
VERSION     DBMVGT010000105.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3862)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3862)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3862
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.105"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..654
                     /locus_tag="AC0DU4_002000"
     CDS             <1..654
                     /locus_tag="AC0DU4_002000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DnaB-like helicase C-terminal domain-containing
                     protein"
                     /protein_id="HIN4237903.1"
                     /translation="TVAIFSLEMGAESLVDRMLAAEGLVESHSIRTGQLTDEEWQKYT
                     IAQGNLANASIYIDDTPGIRITEIRSRSRKLAQETGNLGLILIDYLQLITGTGRENRQ
                     QEVSEISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVA
                     FLYRDDYYERGGEEEEGIPNNKVEVIIEKNRSGARGTVELIFQKEYNKFSSISKREA"
     gene            656..922
                     /locus_tag="AC0DU4_002001"
     CDS             656..922
                     /locus_tag="AC0DU4_002001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001278167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Veg family protein"
                     /protein_id="HIN4237904.1"
                     /translation="MSDAFTDVAKMKKIKEEIKAHEGQVVEMTLENGRKRQKNRLGKL
                     IEVYPSLFIVEFGDVEGDKQVNVYVESFTYSDILTEKNLIHYLD"
     gene            1011..2357
                     /gene="cbpD"
                     /locus_tag="AC0DU4_002002"
     CDS             1011..2357
                     /gene="cbpD"
                     /locus_tag="AC0DU4_002002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase CbpD"
                     /protein_id="HIN4237905.1"
                     /translation="MKILPFIARGTSYYLKMSVKKLVPFLVVGLMLAAGDSVYAYSGG
                     NGSIARGDDYPAYYKNGSQEIDQWRMYSRQCTSFVAFRLSNVNGFEIPAAYGNANEWG
                     HRARREGYRVDNTPTIGSITWSTAGTYGHVAWVSNVMGDQIEIEEYNYGYTESYNKRV
                     IKANTMTGFIHFKDLDGGSVGNSQSSASTGGTHYFKTKSAIKTEPLASGTVIDYYYPG
                     EKVHYDQILEKDGYKWLSYTAYNGSYRYVQLEAVNKNPLGNSVLSSTGGTHYFKTKSA
                     IKTEPLVSGTVIDYYYPGEKVHYDQILEKDGYKWLSYTAYNGSRRYIQLEGVTSSQNY
                     QNQSGNISSYGSNNSSTVGWKKINGSWYHFKSNGSKSTGWLKDGSSWYYLKLSGEMQT
                     GWLKENGSWYYLGSSGAMKTGWYQVSGKWYYSYSSGALAVNTTVDGYRVNSDGERV"
     gene            2613..2903
                     /locus_tag="AC0DU4_002003"
     CDS             2613..2903
                     /locus_tag="AC0DU4_002003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000647657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine-binding protein"
                     /protein_id="HIN4237906.1"
                     /translation="MKASIALQVLPLAQGIDRIAVIDQVIAYLQTQEVTMVVTPFETV
                     LEGEFDELMRILKEALEVAGQEADNVFANVKINVGEILSIDEKLEKYTETTH"
     gene            2866..3624
                     /locus_tag="AC0DU4_002004"
     CDS             2866..3624
                     /locus_tag="AC0DU4_002004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009013602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237907.1"
                     /translation="MRNLRSILRRHISLLGFLGVLLIWQLAGFLKLLPKFILPTPLEI
                     LQPFVRDREFLWHHSWATLRVALLGLILGVLIACLMAVLMDSLTWLNDLIYPMMVVIQ
                     TIPTIAIAPILVLWLGYGILPKIVLIILTTTFPIIVSILDGFRHCDKDMLTLFSLMRA
                     KPWQILWHFKIPVSLPYFYAGLRVSVSYAFITTVVSEWLGGFEGLGVYMIQSKKLFQY
                     DTMFAIIILVSIISLLGMKLVDISEKYVIKWKRS"
     gene            3663..>3862
                     /locus_tag="AC0DU4_002005"
     CDS             3663..>3862
                     /locus_tag="AC0DU4_002005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HIN4237908.1"
                     /translation="MKKTWKVFLTLVTALVAVVLVACGQGTASKDNKEAELKKVDFIL
                     DWTPNTNHTGLYVAKEKGYFKEA"
BASE COUNT         1126 a          625 c          923 g         1188 t
ORIGIN      
        1 acggttgcta ttttttcact cgaaatgggt gcggaaagct tggtagatcg tatgttagct
       61 gcagaaggct tagtggagtc acattctatc cgtacagggc aattgacaga tgaggagtgg
      121 caaaaatata ctattgctca gggtaatcta gctaacgcca gtatctatat cgatgatacg
      181 ccaggtattc ggattacaga gattcgttct cgttctcgta aattggctca agaaactgga
      241 aatcttggtt tgattttgat agactatttg caacttatca cgggaactgg tcgagaaaat
      301 cgtcaacaag aagtttctga aatttctcgt cagttgaaaa tactagccaa ggaattgaag
      361 gttccagtaa tcgctctgag tcagctttct cgtggtgtag aacaacgtca ggacaagaga
      421 ccggtcttgt ctgatattcg tgaatctggg tctattgagc aggacgctga tatcgtagct
      481 tttctctatc gcgatgacta ctatgaacgt ggtggtgaag aagaggaggg tatcccaaat
      541 aataaggtgg aagttattat cgagaaaaac cgtagtggag ctcgtggaac agtggaattg
      601 attttccaaa aagaatacaa taaattttca agtatctcaa agagggaggc ataagatgtc
      661 agatgcattt acagatgtag ccaagatgaa aaaaatcaaa gaagaaatca aggcacatga
      721 gggacaagtc gtagaaatga ctttggagaa tggtcgtaag cgccaaaaaa atagattggg
      781 taagctaatt gaagtttatc catctctatt tattgtggag tttggggatg tggaaggaga
      841 taaacaagtt aatgtttacg ttgaatcctt tacttactca gatattctta cagaaaagaa
      901 tttgattcat tatcttgact aaagtgagaa attttctcac tttttctttt ttctccgaat
      961 aatttaggtg aaggcaatca tcgctttata ttatttttca aggaggaaga atgaaaattt
     1021 taccgtttat agcaagaggg acaagttatt acttgaagat gtcagttaaa aagcttgttc
     1081 cttttttagt agtaggattg atgctagcag ctggtgatag tgtctatgcc tattccggag
     1141 gaaatggatc gattgcgcgc ggggatgatt atcctgctta ttataaaaat gggagccagg
     1201 agattgatca gtggcgcatg tattctcgtc agtgtacttc ttttgtagcc tttcgtttga
     1261 gtaatgtcaa tggttttgaa attccggcag cttatggaaa tgcgaatgaa tggggacatc
     1321 gtgctcgtcg ggaaggttat cgtgtagata atacaccgac gattggttcc attacttggt
     1381 ctactgcagg aacttatggt catgttgcct gggtgtcaaa tgtaatggga gatcagattg
     1441 agattgagga atataactat ggttatacag aatcctataa taaacgagtt ataaaagcaa
     1501 acacgatgac aggatttatt cattttaaag atttggatgg cggcagtgtt gggaatagtc
     1561 aatcctcagc ttcaacaggc ggaactcatt attttaagac caagtctgct attaaaactg
     1621 aacccctagc tagcggaact gtgattgatt actattatcc tggggagaag gttcattatg
     1681 atcagatact tgaaaaagac ggctataagt ggttgagtta tactgcctat aatggaagct
     1741 atcgttatgt tcaattggag gctgtgaata aaaatcctct aggtaattct gttctttctt
     1801 caacaggtgg aactcattat tttaagacca agtctgctat caaaactgaa cccctagtta
     1861 gcggaactgt gattgattac tattatcctg gagagaaggt tcattatgat cagatacttg
     1921 aaaaagacgg ctacaagtgg ttgagttata ctgcctataa tggaagtcgt cgctatatac
     1981 agctagaggg agtgacttct tcacaaaatt atcagaatca atcaggaaat atctctagct
     2041 atggatccaa taatagttca actgtcggtt ggaagaaaat aaatggtagt tggtatcatt
     2101 tcaaatcaaa tggttctaaa tcaacaggat ggctgaaaga cggttctagc tggtattatt
     2161 tgaaattatc tggtgaaatg cagacaggat ggttaaagga gaatggctcg tggtattatc
     2221 tgggtagttc aggggcaatg aaaacaggct ggtaccaggt ctctggtaag tggtattatt
     2281 cttactcttc aggcgcctta gctgttaata cgacggtgga tggctacaga gtaaacagtg
     2341 atggagaacg agtatagaaa attggagtag gagaaatttc ctgctctttt ctgtaagcag
     2401 tttccttgac atttttctta ttttgcgcta tcatatatac atataatata tgggagtctg
     2461 tgtacagtct gagaggaagt gttaaacttc gaccgcacct gatctgggta atgccagcgg
     2521 agggaacgat acttagtcta attttgcacc ttttccatgt atggtaaagg tttttctttt
     2581 tttaaaaagg aaaacgagaa gaggaggttc ttatgaaagc aagcattgcc ttgcaagttt
     2641 tacccctagc acaggggatt gatcggatag ctgttattga tcaggtcatt gcttatctgc
     2701 aaactcaaga agtgacgatg gtagtgacac catttgaaac ggtcttggaa ggggagtttg
     2761 atgagcttat gcgcattcta aaagaagcgc tggaagtggc agggcaggag gcagacaatg
     2821 tctttgccaa tgtcaaaata aatgtaggag agattttaag tattgatgag aaacttgaga
     2881 agtatactga gacgacacat tagtctattg ggctttctcg gagtcttgtt aatctggcag
     2941 ttagcaggtt ttcttaaact tctccccaag tttatcctgc cgacacctct tgaaattctc
     3001 cagccctttg ttcgtgacag agaatttctc tggcaccata gctgggcgac cttgagagtg
     3061 gctttactgg ggctgatttt gggagttttg attgcctgtc ttatggctgt gctcatggat
     3121 agtttgactt ggctcaatga cctgatttac cctatgatgg tggtcattca gaccattccg
     3181 accattgcca tagctcctat cctggtcttg tggctaggtt atgggatttt gcccaagatt
     3241 gtcttgatta tcttaacgac aacctttccc atcatcgtta gtattttgga cggttttagg
     3301 cattgcgaca aggatatgct gaccttgttt agtctgatgc gggccaagcc ttggcaaatc
     3361 ctgtggcatt ttaaaatccc agttagcctg ccttactttt atgcaggtct gagggtcagt
     3421 gtctcctacg cctttatcac aactgtggta tctgagtggt tgggaggttt tgaaggtctt
     3481 ggtgtttata tgattcagtc taaaaaattg tttcagtatg ataccatgtt tgccattatt
     3541 attctggtgt cgattatcag tcttttgggt atgaagctgg tcgatatcag tgaaaaatat
     3601 gtgattaaat ggaaacgttc gtagaattag aatgtttctg aaaaagaaaa gaggaaatca
     3661 aaatgaagaa aacatggaaa gtgtttttaa cgcttgtaac agctcttgta gctgttgtgc
     3721 ttgtggcctg tggtcaagga actgcttcta aagacaacaa agaggcagaa cttaagaagg
     3781 ttgactttat cctagactgg acaccaaata ccaaccacac agggctttat gttgccaagg
     3841 aaaaaggtta tttcaaagaa gc
//
LOCUS       DBMVGT010000106         3801 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.106, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000106 DBMVGT010000000
VERSION     DBMVGT010000106.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3801)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3801)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3801
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.106"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..211)
                     /locus_tag="AC0DU4_002006"
     CDS             complement(<1..211)
                     /locus_tag="AC0DU4_002006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator"
                     /protein_id="HIN4237909.1"
                     /translation="MKVLVAEDQSMLRDAMCQLLTLQPDVESVLQAKNGQEAIQLLEK
                     ESVDIAILDVEMPVKTGLEVLEWIRS"
     gene            complement(213..1310)
                     /locus_tag="AC0DU4_002007"
     CDS             complement(213..1310)
                     /locus_tag="AC0DU4_002007"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HIN4237910.1"
                     /translation="MLERLKSIHYMFWTSLIFMLFPILPVVIGELPAWHLLVDILFVV
                     TYLGVLITKNQRLSWLFWGLMLVYVAGNTAFVAGNYIWFFFFLSNLLIYHFGVRSLKS
                     LHVWTFLLAQVLVVGRLLIFQRIEVEFLVYMLVILTFVDLMTLGSVRIRLVEDLKEAQ
                     VKQNTQINLLLAENERNRIGQDLHDSLGHTFAMLSVKTDLALQLFQMQAYPQVEKELR
                     EIQQISKESMCEVRTIVENLKSRTLTSELETVKKMLEIAGIEVETDNQLDTASLTQEL
                     DSMASMILLELVTNIIKHAKASKAYLKLERTEKELILTVSDDGCGFAFLKGDELHTVR
                     DRVFPFSGEVSVISQKHPTEVQVRLPYKERN"
     gene            complement(1310..2047)
                     /locus_tag="AC0DU4_002008"
     CDS             complement(1310..2047)
                     /locus_tag="AC0DU4_002008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4237911.1"
                     /translation="MKRWIALSKIEFLLTKRQLIYYLLSVGMPTAFYLFFSGIYQDTP
                     GELANFMRDYLISMTAFSMMSTTILSFPAVLHTDKMNNWQKTLRHSPVNMVEYYLSKI
                     TSMLVDYLVSILVVFTVGHFVRGVDMPLVKWVGAAILLIVGSIAFVALGLTLTLLPTS
                     QLMSVVGNLLYLGLAVLGGLWMPISLFPDWMQAVGKCLPTYQLMELLKTFLNEGDINL
                     SATVYLLVFSAVLFGLTIYLQGHKENA"
     gene            complement(2049..2933)
                     /locus_tag="AC0DU4_002009"
     CDS             complement(2049..2933)
                     /locus_tag="AC0DU4_002009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001055970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4237912.1"
                     /translation="MDMIKVQGLHKNIKGKAILKDISFEVAEGECVALIGPNGAGKTT
                     LLDCLLGDKLVTSGQVSIQGLSVTSSQLDYIRGYLPQENVIVQKLKVKELVAFFQSIY
                     PNPLSNQEIDQLLQFDKQQKEQLAEKLSGGQKRLFSFVLTLIGRPKLVFLDEPTAAMD
                     TSTRQRFWEIVQDLKAQGVTILYSSHYIEEVEHTADRILLLNKGELIRDTTPLAMRSE
                     EIEKHFILPIAYKEVVEQSNLVENWTLKQDSLQVVTREADAFWELLAQAGCRMQEIEV
                     NNRSLLNTIFEETQKGDN"
     gene            complement(2920..3114)
                     /locus_tag="AC0DU4_002010"
     CDS             complement(2920..3114)
                     /locus_tag="AC0DU4_002010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237913.1"
                     /translation="MKKAFLYLFIGLSLVVWLVEMFTGWFDQALLRQFIRGAWGLGFM
                     IFIAFPMGMEWLKGEYHGHD"
     gene            complement(3111..3302)
                     /locus_tag="AC0DU4_002011"
     CDS             complement(3111..3302)
                     /locus_tag="AC0DU4_002011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000791802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237914.1"
                     /translation="MKNKMIVAMSLVAAGVMTYLMFSGLDEDFYHFPWELFAGFGMMS
                     WLIREGLKLVSDVKKEFEK"
BASE COUNT         1249 a          829 c          638 g         1085 t
ORIGIN      
        1 ctgatcgtat ccactccaag acttcaagac ctgtcttaac aggcatttct acgtcaagga
       61 tggcgatatc tacagactcc ttttctaata gttggattgc ttcttgccca ttcttggctt
      121 gaaggacaga ctccacatct ggttgaagcg tgagcaattg acacatggca tctcgcaaca
      181 tactttgatc ttctgcgact aatactttca tcttagtttc tctccttata aggtagtcga
      241 acttgcactt ccgttggatg tttctgactg attacactta cttctcctga aaatggaaaa
      301 acacgatctc ggactgtatg gagctcatct ccttttagaa aagcaaagcc gcagccatca
      361 tcacttactg ttaaaatgag ttccttctct gtccgttcta attttaagta agctttagac
      421 gctttggcat gtttgatgat attggtcacc aactcaagca aaatcataga agccattgaa
      481 tccaattctt gagtaaggct agcagtatct agttggttat ctgtttccac ctcaattcca
      541 gcaatttcta acatcttttt cacagtctct agttcggatg tcaaagttct agacttaaga
      601 ttttccacaa tggttcgaac ttcacacatt gattctttgc taatttgctg tatttctctt
      661 aattcctttt ccacttgtgg ataagcctgc atttgaaata gctgcaaggc tagatctgtc
      721 ttgacactaa gcatagcaaa ggtatgtccc agactatcat gcaaatcctg accgatacga
      781 ttgcgctcat tttctgctag caatagattt atctgggtat tttgcttgac ctgagcttct
      841 ttcaaatcct cgacaaggcg aattcgaacc gagcccaaag tcatcaaatc gacaaaagta
      901 agaattacaa gcatatagac tagaaactca acttcgattc tctgaaaaat caaaagtcgc
      961 cccacaacaa ggacttgagc aaggagaaat gtccatacat gtaaagactt taaactacgt
     1021 acgccaaaat gataaattaa gagattggaa aggaaaaaga aaaaccagat ataattccca
     1081 gcaacaaagg cggtattccc agctacatag accagcatga gcccccagaa aagccaagat
     1141 aggcgctggt tcttagttat taaaacaccc aaatacgtca ctacaaatag aatatcaacc
     1201 aataaatgcc aagcaggaag ctccccaatc actacaggta ggatgggaaa aagcataaaa
     1261 atcaaactgg tccaaaacat atagtgtatg cttttcagtc tttcaagcat taagcattct
     1321 ccttatgacc ttgaaggtaa atagtcaaac caaataaaac tgctgaaaaa acaagtaaat
     1381 aaactgtggc tgatagattg atgtcaccct cgtttaagaa ggtcttgagc aactccatca
     1441 attgataggt cgggagacac ttaccaactg cttgcatcca gtctggaaat aaagaaatgg
     1501 gcatccagag tccgcctaaa acagccaatc ctagataaag aagattgccc acaacagaca
     1561 tcagctgact agttggtaag agagtcaagg tcaagccaag tgctacaaaa gcaatactcc
     1621 ccacaatcag caaaatcgca gctccaaccc attttactag aggcatgtct acacctctta
     1681 caaaatgtcc aactgtaaaa acaaccagaa ttgagaccaa ataatcaacc agcatacttg
     1741 ttatctttga tagataatat tctaccatat ttacagggct atgacgcaat gttttctgcc
     1801 agttgttcat cttatcggta tgtaaaacag ctggaaatga gaggatagtt gtcgacatca
     1861 tggaaaaggc agtcatggag atgaggtaat cacgcataaa attcgcgagt tcacctggtg
     1921 tgtcctgata gataccagaa aaaaataaat agaaagccgt cggcatccct accgacaata
     1981 gataatagat taattgtcgt ttggtcaata aaaattctat cttactaagt gctatccatc
     2041 gtttcatctt agttatctcc cttctgcgtc tcttcaaaga ttgtattcaa caaactacga
     2101 ttattaactt cgatttcttg catcctacat cctgcttggg ctaatagttc ccagaaagca
     2161 tctgcttctc gagtgactac ttgtaaagaa tcttgcttta gggtccagtt ttcaaccaaa
     2221 tttgactgct ctacgacttc cttgtaagct ataggaagga taaagtgctt ttctatttcc
     2281 tcgctacgca tagctagagg cgtcgtatct cgaatcaact ctcccttatt taagagcaaa
     2341 atgcggtctg cagtgtgttc cacttcctca atataatggg acgaatagag aatggtaact
     2401 ccctgcgctt ttagatcctg aacaatttcc caaaaacgtt ggcgggttga ggtatccatg
     2461 gccgcagttg gctcatctaa aaagacaagt tttggtcggc caatcaaggt caagacaaaa
     2521 gagaaaagac gcttttgccc acctgacaat ttttctgcca attgctcttt ctgttgcttg
     2581 tcaaactgca acagttgatc gatttcctgg ttgctcaagg gatttggata aatgctttga
     2641 aagaaagcaa ccaactcttt gacctttaat ttctgaacga tgacattttc ttgaggcaga
     2701 taacctctaa tatagtctaa ctgagaactc gtcactgaca agccttggat ggatacttga
     2761 ccgcttgtga ccagtttatc tccaagcaga cagtccaaga gtgtggtctt cccagcacca
     2821 tttggcccaa tcaaggcgac gcattcacct tcagctacct caaaggaaat atccttcaaa
     2881 atagcctttc ccttgatgtt tttatgtaat ccttgaacct taatcatgtc catgatattc
     2941 tcctttcaac cactccattc ccataggaaa ggcgataaaa atcataaatc ctagtcccca
     3001 ggcaccacgg atgaattggc gaagcaaggc ttgatcaaac caacctgtaa acatttctac
     3061 caaccatacc actagtgata gtccaataaa aagatagaga aacgcttttt tcatttttca
     3121 aactcctttt tcacatctga gactaatttc aaaccttctc ggataagcca ggacatcatt
     3181 ccaaatcctg caaatagctc ccaaggaaaa tgatagaaat cttcatccaa tcctgagaac
     3241 atgagataag tcatgactcc tgctgctact aaactcattg cgacaatcat tttatttttc
     3301 atctcttctt cctccgtttc atacttcaat tatagacttt tgaagttggc ggagctagat
     3361 gcttctgtca ctagaaaata tgacaaatgt cataaaaatt ctgtacaaaa caagcaagat
     3421 acactatata ataaaacaca agtagaaaaa atctaaggca gctttcaaaa gagatatcaa
     3481 acccaattca caccataatg taaactaata cttatttaaa atcaaaaaga gcggaaattt
     3541 ttatcgcaca aacacatata ttataagcag agcgaaaaac tcttcaatta ctttcttaaa
     3601 agtttgtaag aattatacaa tctgttaaat tttaatttat gtacctaaac tacagtattc
     3661 attgaacaaa ttaggaaaca aaaaagtata cgctgctaaa atgaattact gaaattcaaa
     3721 aaagagagaa gcaaactgat tctctcttaa tgtatataat atctagttaa aacaaaaaga
     3781 tacgcttacg tatctctgaa a
//
LOCUS       DBMVGT010000107         3736 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.107, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000107 DBMVGT010000000
VERSION     DBMVGT010000107.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3736)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3736)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3736
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.107"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(74..1582)
                     /gene="glpK"
                     /locus_tag="AC0DU4_002012"
     CDS             complement(74..1582)
                     /gene="glpK"
                     /locus_tag="AC0DU4_002012"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004370 - glycerol kinase activity
                     [Evidence IEA];
                     GO_process: GO:0006072 - glycerol-3-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HIN4237915.1"
                     /translation="MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAG
                     WVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAI
                     VWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGE
                     LLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEV
                     RSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNT
                     GEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYA
                     RDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDI
                     IDTMQVDTQTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGL
                     SVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD"
     gene            complement(1741..3168)
                     /locus_tag="AC0DU4_002013"
     CDS             complement(1741..3168)
                     /locus_tag="AC0DU4_002013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4237916.1"
                     /translation="MYLGDLMEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLT
                     KYVTLLNDKALDSGLELTIHSENENLRLSIGAATKGRDIRSLFLESAVKYQILVYLLY
                     HQQFLAHQLAQELVISEATLGRHLAGLNQILSEFDLSIQNGRWRGPEHQIRYFYFCLF
                     RKVWSSQEWEGHMQKPERKQEIANLEEICGASLSVGQKLDLVLWAHISQQRLRVNACQ
                     FQVIEEKMRGYFDNIFYLRLLRKVPSFFAGQHIPLGVEDGEMMIFFSFLLSHRILPLH
                     TMEYILGFGGQLADLLTQLIQEMKKEELLGDYTEDHVTYELSQLCAQVYLYKGYILQD
                     RYKYQLENRHPYLLMEHDFKETAEEIFHALPTFQQGTDLDKKILWEWLQLIEYMAENG
                     GQHMRIGLDLTSGFLVFSRMAAILKRYLEYNRFITIEAYDPSRHYDLLVTNNPIHKKE
                     QTPVYYLKNDLDMEDLVAIRQLLFT"
     gene            3333..>3736
                     /locus_tag="AC0DU4_002014"
     CDS             3333..>3736
                     /locus_tag="AC0DU4_002014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0051082 - unfolded protein binding
                     [Evidence IEA];
                     GO_process: GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HIN4237917.1"
                     /translation="MNKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGR
                     TLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATG
                     EVLVGPFVGNGQFLVITDYGTGNPYNSITPLIS"
BASE COUNT         1077 a          868 c          699 g         1092 t
ORIGIN      
        1 gacaattcac gtgttttctt tgaaaattcc atatttacac actttctaaa taaatcgctt
       61 tattctgcca gtattagtcg tctacttccg caaagacttg agttgctttc acagccttct
      121 tccagccctt gtagagttgt tccttgcgag attcgttcat agatggctca aagagttctc
      181 ctgtctcgtt caagagtttc aactcgtcca agtctttcca gtaccctact gacaaacctg
      241 ctaggaaggc cgctcctaga gctgttgttt ccaggttttt agcacgtgca atgtcaatgc
      301 ctaaaatatc cgcctggaac tgcatgagga agttgttcat ggctgcacca ccatccacct
      361 tcagtacttg aatggcggtc tgagtatcca cttgcatggt gtcgatgata tcacgcactt
      421 gataagcaat agattgcaaa gtcgccttga taaagtcttc tttgcttgtt ccacgagtca
      481 aaccaaagac ggaaccacga gcattttggt tccagtatgg agcgcctaga cctgtaaagg
      541 ctggaacgac ataaacttca tcgttgttgt gagaatcacg agcgtatttt tcagattctg
      601 gtgaattttc aaccatgcga agaccgtcac gaagccactg aatagcactt cctgcgatga
      661 agatagaacc ttccaaggca taataaacct taccgttgat tccgtaacca atggttgtca
      721 agaggttgtt ttcagacaac tgcatctctt ccccagtatt catgatgatg aaagagcctg
      781 ttccataagt attcttaacc atacctggct caaaagccaa ctgtccaaag agggctgctt
      841 gttggtcccc agccatacct gagattggca cctctccacc gtagaaatgg aatggagctg
      901 tcttgccgta gatttcggag ttagaacgaa cttctggaag tatagccttc ggaatgttaa
      961 ggatttccaa aatctcatca tcccatttga gttctttaat gttataaagc atggtacgag
     1021 ctgcatttga gtagtcagtc acgtgagccg caccgtcagt caatttccaa accaaccaag
     1081 tatcgatagt accaaagagc aattcccctt tttctgctcg ctcttgagca ccttctacat
     1141 gatccaaaat ccaacgaacc ttggtagcag agaagtaagc atcaataatc aaaccagtct
     1201 tttcatggaa tttttccaca taaccttggc tttttagttg ctcagccaaa ggtgctgtct
     1261 ggcgtgactg ccaaacgata gcattgtaga taggaagtcc tgttttctta tcccagacaa
     1321 ccgttgtttc acgttggttg gtaatcccga ttgcctcgat ttgatttggc ttgacaccac
     1381 tttcgatgaa agcacccgca ataactgact gaacagagtt ccaaatttca ttggcattgt
     1441 gctcaaccca acctgcctga gggaaaatct gggtaaactc tttttgactc gagctaacct
     1501 tttccccttt tttgttgaaa atgatggcac gagaacttgt agttccctgg tcaatggcca
     1561 tgatgtattt ttcttgtgac atgtactgtc ctcctgataa agatcttgag gtgtttcctc
     1621 tttacactta ctagtataca aaataaagcg ctttcttgtt tatcaacttt ttttaatttt
     1681 taaaaaaatg tgaggagatt gtgtgaattt cacaaaaaag acctggatta accaagcctt
     1741 ttaagtgaat aataactggc gaatcgctac caaatcctcc atatccaagt cattttttaa
     1801 ataatagact ggtgtctgtt ccttcttatg aatcgggtta ttggtaacca gcaaatcata
     1861 atgccgacta gggtcataag cttcaatggt aataaaacga ttgtattcca aataccgttt
     1921 caaaatggct gccatccttg aaaagacaag aaaaccagat gtcaaatcca gaccaatccg
     1981 catatgctgg ccaccgtttt cagccatata ttcgattaac tggagccatt cccagagaat
     2041 cttcttatct aaatctgtcc cctgttgaaa agtaggtaga gcatgaaaaa tctcctctgc
     2101 tgtctcttta aaatcatgtt ccatcagtaa atatggatga cgattctcta actggtactt
     2161 gtagcgatcc tgtaaaatat agcccttata gagatagact tgagcacaaa gctgactgag
     2221 ttcataggtg acatggtcct ctgtataatc ccccaatagt tcctccttct tcatttcttg
     2281 aatcaattgc gtcagtaaat ctgccaactg ccctccaaaa ccaagaatat actccatagt
     2341 atgaagagga agaatgcgat gagataggag aaaagagaag aatatcatca tctcaccatc
     2401 ctcaactcct agtggaatat gttgcccagc aaaaaaggac ggaacctttc tcagcaaacg
     2461 aagataaaag atattgtcaa aataccctcg cattttctct tctatgactt gaaactgaca
     2521 agcattgacc cgaagacgtt gttgactgat gtgagcccag agaaccaagt ccaatttctg
     2581 ccccacagac aaacttgcac cgcagatttc ctctaaattg gcaatctcct gttttctctc
     2641 tggtttctgc atgtgacctt cccattcctg actcgaccag acctttcgga aaagacagaa
     2701 atagaaatag cgaatctgat gctctggacc tcgccaacgt ccattttgga tggataaatc
     2761 aaattctgac agaatctgat ttaaaccagc caagtgacga ccaagcgtag cctcgctaat
     2821 caccaattct tgagccagct gatgggctaa aaactgttgg tggtagagaa gataaaccaa
     2881 aatctggtat ttaacagcac tctccaaaaa taagctccga atatctctcc ccttggtagc
     2941 tgcaccgata gacagacgca aattttcatt ttctgagtga atagtcagct ctaagccact
     3001 atccaaagcc ttgtcattga gcagggtgac atatttggtt agggttgctt ttgaaaatcc
     3061 tgtttcttcc attacagcct tgacggtcgt ctgagactct tgtaatagaa aggaaaggat
     3121 tgaaaattga ccacactcag ctttctccat caaatctcct aaatacattt gttacccctt
     3181 tcattttcta ccttaagcat agcataaatc ttacaaatgc tgaaataatc tgtttctctt
     3241 tttattttca tgctgatttc ctggtccatt atcctgaaaa tcagtaaaca cacggctccc
     3301 cctctgggca tttttatgct aaaatagtag ctatgaataa aattattaaa actatatcag
     3361 aaagcggagc ctttcgtgct tttgtccttg acagcacgga aaccgtccgc actgctcaag
     3421 aaaaacacca aacccaagct agctcaactg tagcgcttgg tcgaactctt atcgctagcc
     3481 agattctcgc agccaatgaa aaaggaaata ccaaacttac agttaaggtg ttgggatcta
     3541 gctctctagg tgctattatc accgtcgctg ataccaaggg gaacgtcaaa ggctacgttc
     3601 aaaatcctgg tgttgacatc aaaaagactg cgactggtga agtcctagtc ggaccttttg
     3661 ttggaaatgg tcaattcctc gttatcacag actacggtac tggaaatcct tacaactcta
     3721 taactcccct catctc
//
LOCUS       DBMVGT010000108         3721 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.108, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000108 DBMVGT010000000
VERSION     DBMVGT010000108.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3721)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.108"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..362
                     /locus_tag="AC0DU4_002015"
     CDS             <1..362
                     /locus_tag="AC0DU4_002015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000897732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0006812 - monoatomic cation transport
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="potassium transporter TrkG"
                     /protein_id="HIN4237918.1"
                     /translation="GLPHANVARRTIASRTVQKSFSVFIIFLMSFLIGLILLGITAKG
                     NPPFIHLIFETISALSTVGVTANLTPDLGKLALSVIMPLMFMGRIGPLTLFVSLADYH
                     PEKKDMIHYMKADISIG"
     gene            376..1041
                     /locus_tag="AC0DU4_002016"
     CDS             376..1041
                     /locus_tag="AC0DU4_002016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001283913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0030001 - metal ion transport [Evidence
                     IEA];
                     GO_process: GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="potassium channel family protein"
                     /protein_id="HIN4237919.1"
                     /translation="MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEP
                     VLARGVIGDITDEELLRSAGIDTCDTVVVATGENLESSVLAVMHCKSLGVPTVIAKVK
                     SQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMKIPQSWA
                     GQSLSKLDLRGKYNLNILGFREQENSPLDVEFGPDDLLKADTYILAVINNQYLDTLVA
                     LNS"
     gene            1176..1334
                     /locus_tag="AC0DU4_002017"
     CDS             1176..1334
                     /locus_tag="AC0DU4_002017"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237920.1"
                     /translation="MKIKDQTRKLAAGCSKHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     NIYTARRR"
     gene            1396..1935
                     /locus_tag="AC0DU4_002018"
     CDS             1396..1935
                     /locus_tag="AC0DU4_002018"
                     /EC_number="2.4.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HIN4237921.1"
                     /translation="MKLLSIAISSYNAAAYLHYCVESLVIGGEQVGILIINDGSQDQT
                     QEIAECLASKYPNIVRAIYQENKCHGGAVNRGLAEASGRYFKVVDSDDWVDPRAYLKI
                     LETLQELESKGQEVDVFVTNFVYEKEGQSRKKSMSYDSVLPVRQIFGWDQVGNFSKGQ
                     YTMMHSLIYRTDLLRASQF"
     gene            2002..2412
                     /locus_tag="AC0DU4_002019"
     CDS             2002..2412
                     /locus_tag="AC0DU4_002019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 2"
                     /protein_id="HIN4237922.1"
                     /translation="MYYLPVDFYRYLIGREDQSVNEQVMIKCIDQQLKVNRLLIDQLD
                     LSQVSHPKMREYLLNHIELTTVISSTLLNRSGTAEHLAKKRQLWTYIQQKNPEVFQAI
                     RKTMLSRLTKHSVLPDRKLSNVVYQITKSVYGFN"
     gene            2528..>3721
                     /gene="pavB"
                     /locus_tag="AC0DU4_002020"
     CDS             2528..>3721
                     /gene="pavB"
                     /locus_tag="AC0DU4_002020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin-binding SSURE repeat adhesin PavB"
                     /protein_id="HIN4237923.1"
                     /translation="MKFNPNQRYTRWSIRRLSVGVASVVVASGFFVLVGQPSSVRADG
                     LNPTPGQVLPEETPGTKEGDLSEKPGDTVLTQAKPEGVTGNTNSLPTPTERTEVSEET
                     SPSSLDTLFEKDEEAQKNPELTDVLKETVDTADVDGTQASPAETTPEQVKGGVKENTK
                     DSIDVPAAYLEKAEGKGPFTAGVNQVIPYELFAGDGMLTRLLLKASDNAPWSDNGTAK
                     NPALPPLEGLTKGKYFYEVDLNGNTVGKQGQALIDQLRANGTQTYKATVKVYGNKDGK
                     ADLTNLVATKNVDININGLVAKETVQKAVADNVKDSIDVPAAYLEKAKGEGPFTAGVN
                     HVIPYELFAGDGMLTRLLLKASDKAPWSDNGDAKNPALSPLGENVKTKGQYFYQVALD
                     GNVAGK"
BASE COUNT         1120 a          721 c          855 g         1025 t
ORIGIN      
        1 taggcttgcc tcatgccaat gttgcgagac gaacgattgc gtcgcgaacg gttcaaaaat
       61 cctttagtgt ctttattatc tttttgatga gcttcttgat aggattgatt ctgctaggga
      121 taacagccaa aggcaatcct ccctttatcc acctcatatt tgaaaccatt tcagctctta
      181 gtacagttgg tgtaacggca aatctgactc ctgaccttgg gaaattggct ctcagtgtta
      241 tcatgccact tatgtttatg ggacgaattg gtcccttgac cttgtttgtt agcttggcag
      301 attaccatcc agaaaagaaa gatatgattc actatatgaa agcagatatt agtattggtt
      361 aagaaaggaa agagcatgtc agatcgtacg attggaattt tgggcttggg aatttttggg
      421 agcagtgtcc tagctgccct agccaagcag gatatgaata ttatcgctat tgatgaccac
      481 gcagagcgca tcaatcagtt tgagccagtt ttggcgcgtg gagtgattgg tgacatcaca
      541 gatgaagaat tattgagatc agcagggatt gatacctgcg ataccgttgt agtcgcgaca
      601 ggtgaaaatc tggagtcgag tgtgcttgcg gttatgcact gtaagagttt gggggtaccg
      661 actgttattg ctaaggtcaa aagtcagacc gctaagaaag tgctagaaaa gattggagct
      721 gactcggtta tctcgccaga gtatgaaatg gggcagtctc tagcacagac cattcttttc
      781 cataatagtg ttgatgtctt tcagttggat aaaaatgtgt ctatcgtgga gatgaaaatt
      841 cctcagtctt gggcaggtca aagtctgagt aaattagacc tccgtggcaa atacaatctg
      901 aatattttgg gtttccgaga gcaggaaaat tccccattgg atgttgaatt tggaccagat
      961 gacctcttga aagcagatac ctatattttg gcagtcatca acaaccagta tttggatacc
     1021 ctagtagcat tgaattcgta aagagggatg acccctcttt tttgatgccc aagatggcaa
     1081 atagagacag aagccccttg tcttctagta aaagttcttc aaaggctgga ctttatggta
     1141 aaatagaagg aagtgacaag agagagtaat actcaatgaa aatcaaagat caaactagga
     1201 aactagctgc gggctgctca aaacactgtt ttgaggttgt ggatagaact gacgaagtca
     1261 gctcaaaaca ctgttttgag gttgcagata gaactgacga agtcagtaac atctatacgg
     1321 caaggcgacg ttgacgcggt ttgaagagat tttcgaagag tataagaaaa aatcagtccc
     1381 ctaaaggagc agattatgaa gttattgtct atcgccattt ctagctataa tgcagcagcc
     1441 tatcttcatt actgtgtgga gtcgctagtg attggtggtg agcaagttgg gattttgatt
     1501 atcaatgacg ggtctcagga tcagactcag gaaatcgctg agtgtttagc tagcaagtat
     1561 cctaatatcg ttagagccat ctatcaggaa aataaatgcc atggcggtgc ggtcaatcgt
     1621 ggcttggcag aggcttctgg gcgctatttt aaagtagttg acagtgatga ctgggtggat
     1681 cctcgtgcct acttgaaaat tcttgaaacc ttgcaggaac ttgagagcaa aggtcaagag
     1741 gtggatgtct ttgtgaccaa ttttgtctat gaaaaggaag ggcagtctcg taagaagagt
     1801 atgagttacg attcagtctt gcctgttcgg cagatttttg gctgggacca ggtcggaaat
     1861 ttctccaaag gccagtatac catgatgcac tcgctgattt atcggacaga tttgttgcgt
     1921 gctagccagt tctaactgcc tgaacatact ttttatgtcg ataatctctt tgtctttacg
     1981 ccccttcagc aggtcaagac catgtactat ctgcctgtcg atttctatcg ttatttgatt
     2041 gggcgtgagg accagtctgt caatgagcaa gtgatgatta agtgcattga ccagcaactc
     2101 aaggtcaatc gactcttgat agaccaactt gatttgtccc aagtgagtca tcccaaaatg
     2161 cgagaatatc tgctgaatca tattgaactc acgacggtga tttccagtac cctgctcaac
     2221 cgatctggaa cagcggagca tctggcaaaa aaacgccaat tgtggaccta tattcagcag
     2281 aaaaatccag aagtctttca ggctattcgt aagaccatgt tgagccgttt gaccaaacat
     2341 tctgtcttgc cagatcgcaa actgtccaat gtcgtctatc aaatcaccaa atctgtttat
     2401 ggatttaatt aatataagtg ttttataaga gggatttaag aaaaatttta actttttctt
     2461 agtccttttt aatttcagga gattatacta gagtcatcaa ataaagaaag actctaagga
     2521 gaatcctatg aaattcaatc caaatcaaag atatactcgt tggtctattc gccgtctcag
     2581 tgtcggtgtt gcctcagttg ttgtggctag tggcttcttt gtcctagttg gtcagccaag
     2641 ttctgtacgt gccgatgggc tcaatccaac cccaggtcaa gtcttacctg aagagacacc
     2701 gggaacgaaa gagggtgact tatcagaaaa accaggagac accgttctca ctcaagcgaa
     2761 acctgagggc gttactggaa atacgaattc acttccgaca cctacagaaa gaactgaagt
     2821 gagcgaggaa acaagccctt ctagtctgga tacacttttt gaaaaagatg aagaagctca
     2881 aaaaaatcca gagctaacag atgtcttaaa agaaactgta gatacagctg atgtggatgg
     2941 gacacaagca agtccagcag aaactactcc tgaacaagta aaaggtggag tgaaagaaaa
     3001 tacaaaagac agcatcgatg ttcctgctgc ttatcttgaa aaagctgaag ggaaaggtcc
     3061 tttcactgcc ggtgtaaacc aagtaattcc ttatgaacta ttcgctggtg atggtatgtt
     3121 aactcgtcta ttactaaaag cttcggataa tgctccttgg tctgacaatg gtactgctaa
     3181 aaatcctgct ttacctcctc ttgaaggatt aacaaaaggg aaatacttct atgaagtaga
     3241 cttaaatggc aatactgttg gtaaacaagg tcaagcttta attgatcaac ttcgcgctaa
     3301 tggtactcaa acttataaag ctactgttaa agtttacgga aataaagacg gtaaagctga
     3361 cttgactaat ctagttgcta ctaaaaatgt agacatcaac atcaatggat tagttgctaa
     3421 agaaacagtt caaaaagccg ttgcagacaa cgttaaagac agtatcgatg ttccagcagc
     3481 ctacctagaa aaagccaagg gtgaaggtcc attcacagca ggtgtcaacc atgtgattcc
     3541 atacgaactc ttcgcaggtg atggcatgtt gactcgtctc ttgctcaagg catctgacaa
     3601 ggcaccatgg tcagataacg gcgacgctaa aaacccagcc ctatctccac taggcgaaaa
     3661 cgtgaagacc aaaggtcaat acttctatca agtagccttg gacggaaatg tagctggcaa
     3721 a
//
LOCUS       DBMVGT010000109         3715 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.109, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000109 DBMVGT010000000
VERSION     DBMVGT010000109.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3715)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3715)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3715
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.109"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..2580
                     /gene="rpoC"
                     /locus_tag="AC0DU4_002021"
     CDS             <1..2580
                     /gene="rpoC"
                     /locus_tag="AC0DU4_002021"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003899 - DNA-directed RNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HIN4237924.1"
                     /translation="FKPFVMREIVARDIVQNVKAAKRLVERGDERIWDILEEVIKEHP
                     VLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNADFDGDQMAIHVPLSEEAQA
                     EARILMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEEAGREGEGMVFKDRDEAVMA
                     YRNGYVHLHSRVGIATDSLNKPWTEEQRHKVLLTTVGKILFNDIMPEGLPYLQEPNNA
                     NLTEGVPAKYFLPLGGDIKEAISNLELNPPFKKKNLGNIIAEIFKRFRTTETSALLDR
                     MKNLGYHHSTLAGLTVGIADIPVVDDKAEIIEESHKRVEQITKQFRRGMITDDERYNA
                     VTAEWRAAREKLEKRLIANQDPKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRI
                     MELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIRED
                     DCGTDRGLLIRSIAEGKEMIESLEERLNGRYTKKTVKHPETGAVIIGPNELITEDKAR
                     EIVNAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGT
                     QLTMRTFHTGGVASNTDITQGLPRVQEIFEARNPKGEAVITEVKGQVTAIEEDASTRT
                     KKVFVKGETGEGEYVVPFTARMRVEVGGQVARGAALTEGSIQPKRLLAVRDVLSVETY
                     LLGEVQKVYRSQGVEIGDKHIEVMVRQMIRKVRVMDPGDTDLLMGTLMDINDFTDANK
                     DVLIAGGVPATGRPVLMGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLLGLK
                     ENVIIGKIIPAGTGMARYRNLEPHAVNEEEYLNPPVEEEGNEETTEVVVDTAVETVEE
                     TVE"
     gene            2691..3104
                     /gene="ndk"
                     /locus_tag="AC0DU4_002022"
     CDS             2691..3104
                     /gene="ndk"
                     /locus_tag="AC0DU4_002022"
                     /EC_number="2.7.4.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004550 - nucleoside diphosphate kinase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="HIN4237925.1"
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEE
                     LIDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTI
                     RGDFAKAAGENEVIQNVVHGSDSEESAKREIALWF"
BASE COUNT         1087 a          799 c          831 g          998 t
ORIGIN      
        1 tttaaaccat ttgtcatgcg tgaaatcgtt gcccgtgata tcgtgcaaaa cgtcaaagca
       61 gctaaacgct tggtggaacg cggagatgag cgtatctggg atatccttga agaagtgatt
      121 aaagaacacc cagtgctttt gaaccgcgca ccgacccttc accgtttggg tatccaagcc
      181 ttcgagccag tcttgattga tggtaaggct cttcgcttgc acccacttgt ctgtgaagcc
      241 tacaatgctg actttgacgg ggaccaaatg gccatccacg taccactttc agaagaagca
      301 caagcagaag ctcgtatcct catgctagct gctgagcaca tcttgaaccc gaaagatggg
      361 aaaccggtag ttactccatc tcaggacatg gttttgggta actactactt gaccatggaa
      421 gaagctggtc gcgaaggtga aggaatggtc ttcaaagacc gtgacgaagc ggttatggct
      481 taccgcaatg gttatgttca cctccactca cgtgttggta tcgcaacaga cagcctcaac
      541 aagccttgga cagaagagca aagacataag gtcttgctta caacagttgg taaaattctc
      601 ttcaacgata tcatgccaga ggggctacca tacttgcaag aaccaaacaa tgccaacttg
      661 acagaaggtg ttccagctaa atacttcttg ccacttggtg gagatatcaa ggaagctatc
      721 agcaatcttg agctcaaccc tccattcaag aagaaaaacc tcggaaatat catcgctgaa
      781 atcttcaaac gtttccgtac gacagaaact tctgccctac ttgaccgcat gaagaacctc
      841 ggttaccacc actcaactct tgcaggattg acagtgggta ttgccgatat cccagtcgtt
      901 gatgacaagg ctgaaatcat tgaagaatca cacaaacgtg tcgaacaaat caccaaacaa
      961 ttccgtcgtg gtatgatcac agacgacgag cgttacaatg ctgttacagc tgaatggcgt
     1021 gctgcccgtg aaaaacttga gaaacgcttg attgctaatc aagatcctaa gaacccaatc
     1081 gttatgatga tggactctgg agcccgtggt aacatctcaa acttctcaca gcttgccggt
     1141 atgcgtggtc tgatggctgc tccgaatgga cgtatcatgg aattgccaat cctttcaaac
     1201 ttccgcgaag gtttgtcggt attggaaatg ttcttctcaa ctcacggtgc tcgtaaaggt
     1261 atgaccgata cggcccttaa gacagccgac tcaggttact tgactcgtcg tttggtcgac
     1321 gttgcccaag acgttatcat ccgtgaggac gactgtggaa ctgaccgtgg tctcttgatc
     1381 cgttctatcg cagaaggaaa agagatgatc gagtctctcg aagagcgtct caacggtcgt
     1441 tacactaaga aaactgttaa acatccagaa actggtgcag tgattattgg tccaaatgaa
     1501 ttgattacag aagacaaggc gcgtgaaatt gtcaatgctg gtgtggaaga agtgactatc
     1561 cgttctgtat ttacatgtaa cactcgtcac ggtgtctgcc gtcactgtta cggtatcaac
     1621 ttggcgactg gtgatgcggt tgaagttggt gaagcagttg gtacaatcgc tgcccaatct
     1681 atcggggaac ctggtacaca gcttacaatg cgtaccttcc acacaggtgg ggttgcctca
     1741 aataccgata tcactcaggg tcttcctcgt gtccaagaaa tctttgaagc ccgcaatcct
     1801 aaaggggaag cggttatcac agaggttaaa ggacaagtta ctgctatcga agaggatgca
     1861 tcaactcgta ccaagaaagt ctttgttaag ggtgaaactg gcgaaggtga atatgtcgtt
     1921 ccatttacag ctcgtatgcg tgtcgaagtt gggggccaag tagcgcgtgg tgctgctctg
     1981 acagaaggtt ctatccaacc aaaacgtctc cttgcagttc gtgatgtctt gtcagttgaa
     2041 acgtaccttc tcggtgaagt acaaaaagtt taccgtagcc aaggggtaga aatcggtgac
     2101 aaacacatcg aggtaatggt tcgtcaaatg atccgtaaag tccgtgtcat ggatccaggt
     2161 gatacagatc ttctcatggg taccctcatg gatatcaatg actttacaga tgccaacaaa
     2221 gatgtcctta tcgcaggtgg agttccagcg acaggtcgcc cagtccttat gggaattacc
     2281 aaagcctcac ttgaaacaaa cagtttcttg tcagcggctt ccttccagga aacaactcgt
     2341 gtccttactg acgcagctat ccgtggtaag aaagaccatc tccttggact taaagaaaat
     2401 gttatcatcg gtaagatcat cccagctggt actggtatgg cccgttaccg taaccttgaa
     2461 ccacatgctg tcaacgaaga agaatacctt aatcctccag tagaggaaga aggaaatgaa
     2521 gaaacaacag aagtagttgt ggatactgcc gttgaaactg tggaagaaac agtagaataa
     2581 gagagaatga gagaaccctc gggttctctc attctctctt ctgaaaactt tctccatttt
     2641 tccacgaaat gtggtaaaat aaaagaaaga agctgacaaa ggagacgggt atggaacaaa
     2701 cattctttat catcaaacca gatggtgtaa aaagagggct agtgggtgaa gtgttaaagc
     2761 gcatcgaaca acgtggattt acaatcgaaa aattggagtt tcgttcacag gtttcagaag
     2821 agttgattga ccagcactat caggacttgg ttggtcagag tttttaccca ccgattcgtg
     2881 aattcatgac ttcaggtcca gttcttgtgg gtgtcatttc tggtcccaaa gtaatcgaaa
     2941 cttggcggac catgatgggt gcaactcgtc cagaagaagc tttaccaggc actattcgag
     3001 gtgactttgc aaaagctgct ggagaaaatg aggttatcca aaatgttgta catggttcag
     3061 attcagaaga gtcagctaag cgagaaattg ctctttggtt ttaagagtgg attggctcaa
     3121 tcaattggtt aaaagctcat ttgaatagaa agtatagtca attagtttaa gacatgacgc
     3181 atgatatcaa actttttagt ttttgatatg gtgcgttttt tgattaagtg actattagtt
     3241 cgtctcgctc cgttaggtgc gagacaaaaa aacacccgct atgcgggtgc gcgtcgaagg
     3301 ttataccaaa aaaactccaa acgcgataca ataaaggtgt tcaatccaat tgtaaagcga
     3361 aaggagaaaa atatggcaca aaaggttctt ttatcctgtt cttgtttcaa ttgactatat
     3421 ttctatactt tttcttcctt tctctgtgaa aatcgcaagt ttttcccacc ttttctcaat
     3481 actgaaacaa catctttcca gaacttcaat aatttctttt tgtgttaaat cattatttaa
     3541 ctaaatcttt ggaggcaata cgttttcaaa gttacttttt taccataggt tttgagcctt
     3601 caacacagat tactaagtca aaaatgctct aaatttttga aattctaaca aattccactc
     3661 aactttatca tcatctttga ctttcacaat atcttcctca aaataacatg gaata
//
LOCUS       DBMVGT010000110         3656 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.110, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000110 DBMVGT010000000
VERSION     DBMVGT010000110.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3656)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3656)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3656
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.110"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1527
                     /gene="fusA"
                     /locus_tag="AC0DU4_002023"
     CDS             <1..1527
                     /gene="fusA"
                     /locus_tag="AC0DU4_002023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HIN4237926.1"
                     /translation="YTNDLGTDILEEDIPAEYLDQAQEYREKLIEAVAETDEELMMKY
                     LEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVIDYLPSPLDIPAI
                     KGINPDTDAEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLQSGSYVLNTSK
                     GKRERIGRILQMHANSRQEIDTVYSGDIAAAVGLKDTTTGDSLTDEKSKIILESINVP
                     EPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLV
                     DRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGK
                     GFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLYDGSYHDVDSSE
                     TAFKIAASLSLKEAAKSAQPAILEPMMLVTITVPEENLGDVMGHVTARRGRVDGMEAH
                     GNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQEEIIKKNKGED
                     "
     gene            1631..>3656
                     /locus_tag="AC0DU4_002024"
     CDS             1631..>3656
                     /locus_tag="AC0DU4_002024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004527 - exonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="exonuclease domain-containing protein"
                     /protein_id="HIN4237927.1"
                     /translation="MSNSFEILMNQLGMPAEMRQAPALAQANIERVVVHKISKVWEFH
                     FVFSNILPIEIFLELKKGLSEEFSKTGNKAVFEIKARSQEFSNQLLQSYYREAFSEGP
                     CASQGFKSLYQNLQVRAEGNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPTFNCQ
                     VDKNDVLTQEQEEAFHAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPVFDFQAKKA
                     AAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSM
                     QKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDLQEVVHYERKDLMPE
                     GERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKA
                     GIQLIYGMEANIVEDRVPIVYNEVEMDLSEATYVVFDVETTGLSAIYNDLIQVAASKM
                     YKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVA
                     HNATFDVGFMNANYERHGLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEH
                     HHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKN
                     QVGLKNIFKLVSLSNTKYFEGVPRIPRTVLDAHREGLILGSACSEGEVFDV"
BASE COUNT         1087 a          702 c          847 g         1020 t
ORIGIN      
        1 tatactaacg accttggtac ggatatcctt gaagaagaca tcccagctga ataccttgac
       61 caagctcaag aataccgtga aaaattgatt gaagcagttg ctgaaactga cgaagaattg
      121 atgatgaaat acctcgaagg tgaagaaatc actaacgaag aattgaaagc tggtatccgt
      181 aaagcgacta tcaacgttga attcttccca gtattgtgtg gttcagcctt caaaaacaaa
      241 ggtgttcaat tgatgcttga tgcggttatc gactaccttc caagtccact tgacatccca
      301 gcaatcaaag gtattaaccc agatacagac gctgaagaaa ctcgtccagc atctgacgaa
      361 gagccatttg cagctcttgc cttcaagatc atgactgacc cattcgtagg tcgtttgaca
      421 ttcttccgtg tttactcagg tgttcttcaa tcaggttcat acgtattgaa tacttctaaa
      481 ggtaaacgtg aacgtatcgg acgtatcctt caaatgcacg ctaacagccg tcaagaaatc
      541 gacactgttt actcaggtga tatcgctgct gccgttggtt tgaaagatac tacaactggt
      601 gactcattga cagatgaaaa atctaaaatc atccttgagt caatcaacgt tccagaacca
      661 gttatccaat tgatggttga gccaaaatct aaagctgacc aagacaagat gggtatcgcc
      721 cttcaaaaat tggctgaaga agatccaaca tttcgcgttg aaacaaacgt tgaaactggt
      781 gaaacagtta tctcaggtat gggtgaactt caccttgacg tccttgttga tcgtatgcgt
      841 cgtgagttca aagttgaagc gaacgtaggt gcgcctcaag tatcttaccg tgaaacattc
      901 cgcgcttcta ctcaagcacg tggattcttc aaacgtcagt ctggtggtaa aggtcaattc
      961 ggtgatgtgt ggattgaatt tactccaaac gaagaaggta aaggattcga attcgaaaac
     1021 gcaatcgtcg gtggtgtggt tcctcgtgaa tttatcccag cggttgaaaa aggtttggta
     1081 gaatctatgg ctaacggtgt tcttgcaggt tacccaatgg ttgacgttaa agctaagctt
     1141 tatgatggtt catatcacga tgtcgactca tctgaaactg ccttcaagat tgcggcttca
     1201 ctttccctta aagaagctgc taaatcagca caaccagcta tccttgaacc aatgatgctt
     1261 gtaacaatca ctgttccaga agaaaacctt ggtgatgtta tgggtcacgt aactgctcgt
     1321 cgtggacgtg tagatggtat ggaagcacac ggtaacagcc aaatcgttcg tgcttacgtt
     1381 ccacttgctg aaatgttcgg ttacgcaaca gttcttcgtt ctgcatctca aggacgtggt
     1441 acattcatga tggtatttga ccactacgaa gatgtaccta agtcagtaca agaagaaatt
     1501 attaagaaaa ataaaggtga agactaatcc gtcctcactc tagaaggaag tcacttagtg
     1561 gcttcctttt gtctttagaa aatacctcta aatatggtaa aatagtagaa gaataatgtg
     1621 aggaaaatga atgtcaaata gttttgaaat tttgatgaat caattgggga tgcctgctga
     1681 aatgagacag gctcctgctt tagcacaggc caatattgag cgagttgtgg ttcataaaat
     1741 tagtaaggta tgggagtttc atttcgtatt ttctaatatt ttaccgattg aaatcttttt
     1801 agaattaaag aaaggtttga gcgaagaatt ttctaagaca ggcaataaag ctgtttttga
     1861 aattaaggct cggtctcaag aattttcaaa tcagctcttg cagtcctact atagggaggc
     1921 tttctctgaa ggtccatgtg ctagtcaagg ttttaagtcc ctttatcaaa atttgcaagt
     1981 tcgtgctgag ggtaatcagc tatttattga aggatctgag gcgattgata aggaacattt
     2041 taagaagaat catcttccta atttagccaa acaacttgaa aagtttggtt ttccaacttt
     2101 taactgtcaa gtcgataaga atgatgtcct gacccaagag caggaagagg cctttcatgc
     2161 tgaaaatgag cagattgttc aagctgccaa tgaggaagcg ctccgtgcta tggaacaact
     2221 ggagcagatg gcacctcctc cagcggaaga gaaaccagtc tttgattttc aagcgaaaaa
     2281 agctgcagct aaacccaagc tggataaggc ggagattact cctatgatcg aagtgacgac
     2341 agaggaaaat cgtctggtat ttgaaggggt tgtttttgat gtggagcaaa aagtgactag
     2401 aacaggtcgt gttttaatca actttaaaat gacggactac acttcaagtt tttctatgca
     2461 aaagtgggtt aaaaacgagg aagaggccca gaagtttgat ctcatcaaga agaattcttg
     2521 gctccgagtt cgagggaatg tggagatgaa taacttcaca cgcgatttga ctatgaacgt
     2581 acaggatctg caggaagttg ttcactatga gcggaaggat ttgatgccag aaggtgagcg
     2641 tcgggttgag tttcatgctc atactaacat gtcgactatg gatgctttgc cagaggtcga
     2701 agagattgtt gcaacagctg ctaagtgggg acacaaggcg gttgctatca cggaccatgg
     2761 gaatgtccag tcctttccac atggctataa ggcggctaag aaagcgggaa tccagctgat
     2821 ctatgggatg gaagccaata tcgtggagga ccgtgtccct atcgtctata acgaagtgga
     2881 gatggacttg tcagaagcaa cctacgtggt ctttgacgtg gaaacgacgg gactttcagc
     2941 tatctataat gacttgattc aggttgcggc ctctaagatg tacaagggga atgttattgc
     3001 tgaatttgat gaatttatca atcctgggca tcccttgtca gcctttacta cagagttaac
     3061 tggaattaca gatgatcatg tcaaaaatgc caaaccacta gaacaagttt tgcaagaatt
     3121 ccaagaattt tgcaaggata cggtcctagt tgcccacaat gctacctttg acgttggctt
     3181 tatgaatgct aattatgagc gtcatggtct tccaaagatt agtcagccag ttattgatac
     3241 gctggagttt gctagaaacc tctatcctga gtataaacgc catggtttgg ggcctttgac
     3301 caagcgtttt ggtgtggcct tggaacatca ccacatggcc aattacgatg cggaagcgac
     3361 tggtcgtctg cttttcatct ttatcaaaga ggtagcagaa aaacatggtg tgaccgattt
     3421 agctagactc aacattgatc taatcagtcc agattcttac aaaaaagctc ggatcaagca
     3481 tgcgaccatc tatgtcaaga atcaggtagg tctaaaaaat atctttaagc tggtttcctt
     3541 gtctaatacc aagtattttg aaggagtgcc acggattccg agaacggttc tagatgccca
     3601 tcgagagggc ttgattttag gttcagcctg ttcagagggt gaagtttttg acgtgg
//
LOCUS       DBMVGT010000111         3637 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.111, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000111 DBMVGT010000000
VERSION     DBMVGT010000111.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3637)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3637)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3637
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.111"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..599
                     /locus_tag="AC0DU4_002025"
     CDS             <1..599
                     /locus_tag="AC0DU4_002025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HIN4237928.1"
                     /translation="DKAVNPPNVMGATKRVAELIVTGFNQRSQSTYCAVRFGNVLGSR
                     GSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAKDGEVFILDMGKP
                     VKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVDNQVMDKIFVGKV
                     NVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE"
     gene            complement(685..942)
                     /locus_tag="AC0DU4_002026"
     CDS             complement(685..942)
                     /locus_tag="AC0DU4_002026"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237929.1"
                     /translation="MKIKEQTRKLAAGCSKHCFKIVDGTDEVSSKHCFKVVDGTDEVS
                     SKHCFEVADRTDEVSSKHCFKVVDGTDEVSNHIRQGDVDVI"
     gene            complement(992..1624)
                     /locus_tag="AC0DU4_002027"
     CDS             complement(992..1624)
                     /locus_tag="AC0DU4_002027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HIN4237930.1"
                     /translation="MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIR
                     GFMGPPLESSFATCLSKDQISEAMQIYRSYYKAKGIYEAQLFPQIIDLLEELSSSYPL
                     YITTTKNTSTAQDMAKNLEIHHFFDGIYGSSPEAPHKADVIHQALQTHQLAPEQAIII
                     GDTKFDMLGARETGIQKLAVTWGFGEQADLLNYQPDYIAHKPLEVLAYFQ"
     gene            complement(1646..2518)
                     /gene="sdaAA"
                     /locus_tag="AC0DU4_002028"
     CDS             complement(1646..2518)
                     /gene="sdaAA"
                     /locus_tag="AC0DU4_002028"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0006094 - gluconeogenesis [Evidence IEA];
                     GO_process: GO:0006565 - L-serine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent,
                     subunit alpha"
                     /protein_id="HIN4237931.1"
                     /translation="MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLME
                     RNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIENGKTLSDYTILSAARNAIAVNE
                     HNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASI
                     SGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEV
                     PCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLAT
                     TPTGRRLQKEIFGE"
     gene            complement(2527..3198)
                     /gene="sdaAB"
                     /locus_tag="AC0DU4_002029"
     CDS             complement(2527..3198)
                     /gene="sdaAB"
                     /locus_tag="AC0DU4_002029"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA];
                     GO_process: GO:0006094 - gluconeogenesis [Evidence IEA];
                     GO_process: GO:0006565 - L-serine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent
                     subunit beta"
                     /protein_id="HIN4237932.1"
                     /translation="MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPT
                     EVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKD
                     SNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDI
                     PGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHN
                     VNFFK"
     gene            3440..>3637
                     /locus_tag="AC0DU4_002030"
     CDS             3440..>3637
                     /locus_tag="AC0DU4_002030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HIN4237933.1"
                     /translation="MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLS
                     EIAETHNTTVEKLAENNHIDNI"
BASE COUNT         1052 a          745 c          786 g         1054 t
ORIGIN      
        1 cagataaggc agttaatcca ccaaatgtta tgggagcaac caagcgcgtg gcggagttga
       61 ttgtcactgg ctttaaccaa cgtagccaat caacctactg tgcagttcgt tttgggaatg
      121 ttcttggtag ccgtggtagt gtcattccag tctttgaacg tcagattgct gaaggtgggc
      181 ctgtaacggt gacagacttc cgcatgaccc gttactttat gaccattcca gaagctagtc
      241 gtctggttat ccatgctggt gcttatgcca aagatgggga agtctttatc cttgatatgg
      301 gcaaaccagt caagatttat gacttggcca agaagatggt gcttctaagt ggccacactg
      361 agagtgaaat tccaatcgtt gaagttggaa tccgcccagg tgaaaaactc tacgaagaac
      421 tcttggtatc aaccgaactc gttgacaatc aagttatgga taagattttc gttggtaagg
      481 ttaatgtcat gcctttagaa tccatcaatc aaaagattgg agagttccgc actctcagtg
      541 gagatgagtt gaagcaagct attatcgcct ttgctaatca aacaacccac attgaataaa
      601 aaagaaaaac gcatattatc aagttaaaca accttggtaa tatgcgtttt attatgtaga
      661 gacttatact cttcgaaaat ctcttcaaat cacgtcaacg tcgccttgcc gtatatggtt
      721 actgacttcg tcagttccat ctacaacctt aaaacagtgt tttgagctga cttcgtcagt
      781 tctatctgca acctcaaaac agtgttttga gctgacttcg tcagttccat ccacaacctt
      841 aaaacagtgt tttgagctga cttcgtcagt tccatctaca atcttaaaac agtgttttga
      901 gcagcccgca gctagtttcc tagtttgctc tttgattttc attgagtatt acttcatttt
      961 cttctgaaat ggagttgtta cccagtctat gctattgaaa atacgccaaa acttctaagg
     1021 gtttgtgagc gatataatca ggttgatagt ttagtagatc tgcttgctct ccaaatcccc
     1081 aagtgacggc caatttctga atacctgttt ctcgagctcc cagcatatca aacttggtat
     1141 ctccgatgat gatggcttgt tctggtgcta gttgatgtgt ctgtaaggct tggtgaatga
     1201 catctgcctt atggggtgct tcagggctag aaccataaat accatcaaag aaatgatgga
     1261 tttccaagtt tttggccatg tcttgagcag tagatgtatt ctttgtcgtg gtgatgtaga
     1321 gtggataact gctcgataac tcctcaagca agtctataat ctgaggaaag agttgagctt
     1381 catagatgcc ttttgcctta tagtaagaac gatatatctg catggcttca gaaatttggt
     1441 ctttggacag gcaggtcgca aaactacttt cgagaggtgg tcccataaaa ccacgaatag
     1501 ttttggcatc agggctaggc acccccagct ctttaaaggt ataggtaaag gcattgtgaa
     1561 tcccgataga actatcaacg agggttccat ccaaatcgaa aaaaatcgct gtgatagagg
     1621 tcatggtttc tcctatttga taagcttatt ctccgaaaat ctctttttgg aggcgacgac
     1681 cagtaggggt ggtagcgagt ccaccttcag ctgtttcacg aaaggcagtt ggcatgcttg
     1741 ctcctacttg gtacatggca tcgatcactt catccacagg gattttagat tcgatacctg
     1801 ccaaggccat gtctgctgcg atgaaagcaa agctagctcc catggcatta cgtttgacac
     1861 agggaacttc gaccaaacct gcaacagggt cacagatgag gcctagcata tttttaatga
     1921 caaaggcaat agcttgactg gcctgataag gtgttccacc tgcagccaga gtcaaggcgg
     1981 cagcactcat agcagaggct gaaccaactt cagcttgaca cccaccctca gcacctgaga
     2041 tggaggcatt gtttgcgatg actagtccaa aggcaccagc agcaaagagg aaatccaatt
     2101 gttgctcgtg gctgaggtct aatttttcaa tagcagcagt gagaacggat ggcagacagc
     2161 cagcacttcc agcggttgga gtggcacaga ccaagcccat tttggcattg tgttcattga
     2221 ctgcgatggc atttcgggca gccgagagaa tcgtataatc tgacagagtt tttccgtttt
     2281 cgatgtagtg atccaatttg gcagcatctc cacctgtcag gccactacga gatttatttt
     2341 cattgaggcc aagttggaca gaggctttca taacttccag attgcgttcc atgagaagga
     2401 agacttcttc acgttcgcga ccggtcaatt caaactctgt tgtaatcatg agttctgcga
     2461 catttccttg aaagtccaga tctgcttgct cgaccaattc tttgatagaa taaaacatgc
     2521 ttcctcctat ttaaagaaat tgacattgtg gagatgaggg atttttcgaa tttcttcgat
     2581 agcctcatca cagttgcgac tgtcaacttc gataatcata atggcttttt caccagcttt
     2641 ttcacgagtg acattcatct gggcgatatt gataccatag cgggaaagcg cctctgtaac
     2701 aagggcaatc atacctggaa tatcttgatg aacgatgatg atagtcggtg tattcatatt
     2761 gagagagacg gcaaaaccat tgagttcggt tacctgaata tttcctccac cgatagaaat
     2821 accagtcacg ctgatggtct tgtgggcatt tttaacagta attttagtgg tgttagggtg
     2881 aggggcattg ctgtctttct gaatggtcca gacaatcttg ataccacgct tgtgggcaat
     2941 ttccagacta tttggaattt caggatcatc tgtatccatt cctaaaatac ctgcaacaag
     3001 ggctaggtct gttccgtgac cacgataggt cttggcaaat gagttaaaaa gttggaattc
     3061 aacttctgtc ggagtatcat caaaaatgga agagacaatc ttcccaatac gaacagcacc
     3121 agcggtatgg ctactagatg ggccaatcat aactggtccg atgatatcaa agacagattg
     3181 aaaacgaagt gatttcatca gtttcccctt ataaaaattc ttatctctat tatatcaaag
     3241 aatgaggggc ttggctttaa ttgtggatga aaacctttct aatacctcaa atagcataaa
     3301 aatagtatct tttatgacaa aaaacacctt atttagggaa ataaaaaata attttgtaat
     3361 atttctacat aaaagtgtca agaaacggta atatttaaag ggtatgatag aactatagaa
     3421 agaaggagaa ttttcgaata tgaaatcaat aactaaaaag attaaagcaa ctcttgcagg
     3481 agtagctgcc ttgtttgcag tatttgctcc atcatttgta tctgctcaag aatcatcaac
     3541 ttacactgtt aaagaaggtg atacactttc agaaatcgct gaaactcaca acacaacagt
     3601 tgaaaaattg gcagaaaaca accacattga taacatt
//
LOCUS       DBMVGT010000112         3470 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.112, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000112 DBMVGT010000000
VERSION     DBMVGT010000112.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3470)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3470)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3470
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.112"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            505..1776
                     /locus_tag="AC0DU4_002031"
     CDS             505..1776
                     /locus_tag="AC0DU4_002031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000095461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HIN4237934.1"
                     /translation="MSSKFMKSTAVLGTATLASLLLVACGSKTADKPADSGSSEVKEL
                     TVYVDEGYKSYIEEVAKAYEKEAGVKVTLKTGDALGGLDKLSLDNQSGNVPDVMMAPY
                     DRVGSLGSDGQLSEVKLSDGAKTDDTTKSLVTAANGKVYGAPAVIESLVMYYNKDLVK
                     DAPKTFADLENLAKDSKYAFAGEDGKTTAFLADWTNFYYTYGLLAGNGAYVFGQNGKD
                     AKDIGLANDGSIAGINYAKSWYEKWPKGMQDTEGAGNLIQTQFQEGKTAAIIDGPWKA
                     QAFKDAKVNYGVATIPTLPNGKEYAAFGGGKAWVIPQAVKNLEASQKFVDFLVATEQQ
                     KVLYDKTNEIPANTEARSYAEGKNDELTTAVIKQFKNTQPLPNISQMSAVWDPAKNML
                     FDAVSGQKDAKTAANDAVTLIKETIKQKFGE"
     gene            1887..3179
                     /locus_tag="AC0DU4_002032"
     CDS             1887..3179
                     /locus_tag="AC0DU4_002032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000414940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HIN4237935.1"
                     /translation="MEKQQPSKAALLSIIPGLGQIYNKQKAKGFIFLGVTIVFVLYFL
                     ALATPELSNLITLGDKPGRDNSLFMLIRGAFHLIFVIVYVLFYFSNIKDAHTIAKRIN
                     NGIPVPRTLKDMIKGIYENGFPYLLIIPSYVAMTFAIIFPVIVTLMIAFTNYDFQHLP
                     PNKLLDWVGLTNFTNIWSLSTFRSAFGSVLSWTIIWALAASTLQIVIGIFTAIIANQP
                     FIKGKRIFGVIFLLPWAVPAFITILTFSNMFNDSVGAINTQVLPILAKFLPFLDGALI
                     PWKTDPTWTKIALIMMQGWLGFPYIYVLTLGILQSIPNDLYEAAYIDGANAWQKFRNI
                     TFPMILAVAAPTLISQYTFNFNNFSIMYLFNGGGPGSVGGGAGSTDILISWIYRLTTG
                     TSPQYSMAAAVTLIISIIVISISMIAFKKLHAFDMEDV"
     gene            3181..>3470
                     /locus_tag="AC0DU4_002033"
     CDS             3181..>3470
                     /locus_tag="AC0DU4_002033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001065636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="maltose ABC transporter permease"
                     /protein_id="HIN4237936.1"
                     /translation="MNNSIKLKRRLTQSLTYLYLIGLSIVIIYPLLITIMSAFKAGNV
                     SAFKLDTNIDLNFDNFKGLFTETLYGTWYLNTLIIALITMAVQTSIIVLAGYA"
BASE COUNT         1060 a          733 c          610 g         1067 t
ORIGIN      
        1 cagacgcaaa cgtttgcgtt acttataagt atactccttt tcaagcataa ttgcaagcgt
       61 ttttaaaaaa cttttttgat tatttttaag gagactaact cattttagca aagataactt
      121 aaaactatct aatcctaaag tttgactctc acgagacagt atacaaagta caaaacctcc
      181 ttagggagct tgaatttata tgcaacaaag cacaaacgtc tatagaaaat agatatagat
      241 tagaaacagg gaggtacccc tcctgatttc cctctttaga cagattccat atatttttat
      301 taaaaatact gtattcttat ctatttcata cttttcttct attaaaatgc aaaattatac
      361 tatcaaatca agcttaaaaa ttttttaaaa tttttacaaa aaatacttgc aaccgttttc
      421 tatttgtgct atactaagct cataaaggaa aacgtttgcg tttccttatc aataaaactt
      481 gctattcttt aggaggaata cactatgtca tctaaattta tgaagagcac tgcggtgctt
      541 ggaactgcta cacttgctag cttgcttttg gtagcttgcg gaagcaaaac tgctgataag
      601 cctgctgatt ctggttcatc tgaagtcaaa gaactcactg tatatgtaga cgagggatat
      661 aagagctata ttgaagaggt tgctaaagct tatgaaaaag aagctggagt aaaagtcact
      721 cttaaaactg gtgatgctct aggaggtctt gataaacttt ctcttgacaa ccaatctggt
      781 aatgtccctg atgttatgat ggctccatac gaccgtgtag gtagccttgg ttctgacgga
      841 caactttcag aagtgaaatt gagcgatggt gctaaaacag acgacacaac taaatctctt
      901 gtaacagctg ctaatggtaa agtttacggt gctcctgccg ttatcgagtc acttgttatg
      961 tactacaaca aagacttggt gaaagatgct ccaaaaacat ttgctgactt ggaaaacctt
     1021 gctaaagata gcaaatacgc attcgctggt gaagatggta aaactactgc cttcctagct
     1081 gactggacaa acttctacta tacatatgga cttcttgccg gtaacggtgc ttacgtcttt
     1141 ggccaaaacg gtaaagacgc taaagacatc ggtcttgcaa acgacggttc tatcgcaggt
     1201 atcaactacg ctaaatcttg gtacgaaaaa tggcctaaag gtatgcaaga tacagaaggt
     1261 gctggaaact taatccaaac tcaattccaa gaaggtaaaa cagctgctat catcgacgga
     1321 ccttggaaag ctcaagcctt taaagatgct aaagtaaact acggagttgc aactatccca
     1381 actcttccaa atggaaaaga atatgctgca ttcggtggtg gtaaagcttg ggtcattcct
     1441 caagccgtta agaaccttga agcttctcaa aaatttgtag acttccttgt tgcaactgaa
     1501 caacaaaaag tattatatga taagactaac gaaatcccag ctaatactga ggctcgttca
     1561 tacgctgaag gtaaaaacga tgagttgaca acagctgtta tcaaacagtt caagaacact
     1621 caaccactgc caaacatctc tcaaatgtct gcagtttggg atccagcgaa aaatatgctc
     1681 tttgatgctg taagtggtca aaaagatgct aaaacagctg ctaacgatgc tgtaacattg
     1741 atcaaagaaa caatcaaaca aaaatttggt gaataaaaaa tttgttcaag gggggtggaa
     1801 atcaaatccc cctttgaatt tatcaataga gacacaaata atttagcttt cttataaaaa
     1861 agtagtatcc tatgaaagga gttaatatgg aaaagcaaca acctagtaaa gcagccctgc
     1921 tgtctatcat tcctgggtta ggacagattt acaataaaca aaaagccaaa ggttttatct
     1981 tccttggtgt aaccatcgta tttgtccttt acttcctagc acttgcaacc cctgaattga
     2041 gcaacctcat cactcttggt gacaaaccag gtcgtgataa ttccctcttt atgctgattc
     2101 gtggtgcctt ccatctaatc tttgtaatcg tttatgtact cttttatttc tcaaatatca
     2161 aagatgcaca tacgattgca aaacgcatta acaatggaat tccagttcca cgcacactca
     2221 aagacatgat caaagggatt tatgaaaatg gcttccctta cctcttgatc attccatctt
     2281 atgttgccat gaccttcgcg attatcttcc cagttatcgt aaccttgatg atcgccttta
     2341 ccaactacga cttccaacac ttgccaccaa acaagttgtt ggactgggtt ggtttgacca
     2401 actttacaaa catttggagc ttgagtacct tccgttctgc ctttggttct gttctttctt
     2461 ggactatcat ttgggctttg gcagcttcta ctttacaaat cgtaattggt atcttcacag
     2521 ctatcattgc caaccaacca tttatcaaag gaaaacgtat ctttggtgtt attttccttc
     2581 ttccttgggc tgtcccagcc ttcatcacta tcttgacatt ctcaaacatg tttaacgata
     2641 gtgtcggtgc tatcaacact caagtattgc caatcttggc taaattcctt cctttccttg
     2701 atggagctct tattccttgg aaaacagacc caacttggac taagattgcc ttgattatga
     2761 tgcaaggttg gctcggattc ccatacatct acgttttgac tttgggtatc ttgcaatcta
     2821 ttcctaacga cctttacgaa gcagcttata ttgacggtgc caacgcttgg caaaaattcc
     2881 gcaacatcac tttcccaatg attttggctg ttgcggcacc tactttgatt agccaataca
     2941 ccttcaactt taacaacttc tctatcatgt acctcttcaa tggtggagga cctggtagtg
     3001 tcggaggtgg agctggttca accgatatct tgatctcatg gatctaccgt ttgacaacag
     3061 gtacatctcc tcaatactca atggcggcag ctgttacctt gattatctct atcattgtca
     3121 tctcaatctc tatgatcgca ttcaagaaac tacacgcatt tgatatggag gacgtctaag
     3181 atgaataact caattaaact caaacgtaga ctgactcaaa gccttactta cctttacctg
     3241 attggtctat caattgtaat tatctatcca ctgttgatta ccattatgtc agcctttaaa
     3301 gcaggtaacg tctcagcctt taaactagat actaatatcg acctcaattt tgataacttt
     3361 aaaggcctct tcactgaaac cttgtacggt acttggtacc tcaacacttt gattatcgcc
     3421 ttaattacca tggctgttca aacaagtatc atcgtacttg ctggttatgc
//
LOCUS       DBMVGT010000113         3450 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.113, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000113 DBMVGT010000000
VERSION     DBMVGT010000113.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3450)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3450)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3450
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.113"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            610..1956
                     /gene="gdhA"
                     /locus_tag="AC0DU4_002034"
     CDS             610..1956
                     /gene="gdhA"
                     /locus_tag="AC0DU4_002034"
                     /EC_number="1.4.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016639 - oxidoreductase activity, acting
                     on the CH-NH2 group of donors, NAD or NADP as acceptor
                     [Evidence IEA];
                     GO_process: GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="HIN4237937.1"
                     /translation="MTSAKEYIQSVFETVKARNGHEAEFLQAVEEFFNTLEPVFEKHP
                     EYIEENILARITEPERVISFRVPWVDRDGKVQVNRGYRVQFNSAVGPYKGGLRFHPTV
                     NQGILKFLGFEQIFKNVLTGLPIGGGKGGSDFDPKGKTDAEVMRFCQSFMTELQKHIG
                     PSLDVPAGDIGVGGREIGYLYGQYKRLNQFDAGVLTGKPLGFGGSLIRPEATGYGLVY
                     YTEEMLKANGNSFAGKKVVISGSGNVAQYALQKATELGATVISVSDSNGYVIDENGID
                     FDLLVDVKEKRRARLTEYAAEKATATYHEGTVWTYAGNYDIALPCATQNEINGEAAKR
                     LVAQGVICVSEGANMPSDLDAIKVYKENGIFYGPAKAANAGGVAVSALEMSQNSLRLS
                     WTREEVDGHLKDIMTNIFNTAKTTSETYGLDKDYLAGANIAAFENVANAMIAQGIV"
     gene            complement(2462..2632)
                     /locus_tag="AC0DU4_002035"
     CDS             complement(2462..2632)
                     /locus_tag="AC0DU4_002035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237938.1"
                     /translation="MKKENEYVILTTASLGVMIGIVFAIFLDFPVEYGISLGLLNGIV
                     LGSLIVYKNNKN"
     gene            complement(2645..3217)
                     /locus_tag="AC0DU4_002036"
                     /pseudo
     CDS             complement(2645..3217)
                     /locus_tag="AC0DU4_002036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082046.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
     gene            complement(3240..>3450)
                     /locus_tag="AC0DU4_002037"
     CDS             complement(3240..>3450)
                     /locus_tag="AC0DU4_002037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="transposase family protein"
                     /protein_id="HIN4237939.1"
                     /translation="PRKSSKLKPLTVEDKTYNHALSKDRSKVENIFAKVKTFKMFSTT
                     YRNHRKRFGLRMNLSAGIINHELGF"
BASE COUNT         1079 a          632 c          575 g         1164 t
ORIGIN      
        1 gctaaatcgt tgtttgatta cagtctaaaa gctctataat ctctttataa gatttgccca
       61 tcagacgaaa tatagtagat tgaaactaga atagtacacc tctacttcta aaacattgtt
      121 agaaatcgat ttgactgtcc tgatcgattt gccctgttct tgtttcgttt tactatagaa
      181 cgatttgaag gcgtttatga tatttagctg tacgagagtc ttttaaaagt gttttgatgg
      241 cttggatttc ttctttagtt gatttcatat cactattata taatgctttt tgattttagt
      301 ctggtataaa tattgctttc ctccaaaatg gtcataattt tactagcaaa tctaacatat
      361 cacggataaa ttaacaagtg atttctgaat tgctaaacat tttcttttct tatagcatac
      421 catactttaa gattttgtct ttgagaaaga tatttccaag aaaaacgttc gtttttttat
      481 ctattttcaa aaaaaaccaa aaactgaatt gaaagaattt ttagaaaatt tctgtttttt
      541 ctttacagtg aaaaaaaatt ctgctataat gtcttatgta ataaaatatg acaataaaag
      601 gagaacgata tgacatctgc taaagaatat atccaaagcg tgtttgaaac tgtaaaagct
      661 cgtaacgggc acgaggctga attcctccaa gctgttgaag aatttttcaa cactttggaa
      721 cctgtatttg aaaaacaccc tgagtatatc gaagaaaata tcttggcacg tattactgag
      781 cctgagcgcg tgatttcttt ccgtgttcct tgggttgacc gtgatggaaa agttcaagta
      841 aaccgcggct accgtgttca attcaactca gctgttggac catataaagg cggacttcgt
      901 ttccacccaa ctgtaaacca agggattttg aaattcctcg gatttgaaca aatctttaaa
      961 aacgtcttga ctggacttcc tatcggtgga ggtaaaggtg gatcagactt cgatcctaaa
     1021 ggtaaaacag atgctgaagt gatgcgcttc tgccaaagct tcatgactga attgcaaaaa
     1081 cacatcggac catcacttga cgtacctgct ggtgatatcg gtgttggtgg acgtgaaatt
     1141 ggttaccttt acggtcaata caaacgtctt aaccaatttg atgctggtgt cttgactggt
     1201 aaacctcttg gatttggtgg tagcttgatt cgtccagaag caactggtta cggtttggtt
     1261 tactatactg aagaaatgct caaagctaac ggtaacagct ttgctggtaa gaaagtcgtt
     1321 atttcaggtt ctggtaacgt tgctcaatat gctcttcaaa aagcaactga actcggtgca
     1381 actgttattt ctgtttctga ctcaaatggt tatgtcatcg atgaaaatgg tatcgacttc
     1441 gatcttttgg ttgatgttaa agaaaaacgt cgtgctcgtt tgactgagta tgcagctgaa
     1501 aaagcaactg caacctacca cgaaggtact gtatggactt acgctggaaa ctatgacatt
     1561 gctcttccat gtgccactca aaacgaaatc aacggtgaag cagctaaacg tttggttgct
     1621 caaggcgtta tctgtgtatc tgaaggtgcc aacatgccga gcgaccttga tgccatcaaa
     1681 gtttacaaag aaaatggtat cttctacgga cctgcaaaag ctgccaacgc tggtggtgta
     1741 gccgtttcag ctcttgaaat gagccaaaac agtcttcgcc tctcatggac tcgtgaagaa
     1801 gttgatggcc atctcaaaga catcatgaca aacatcttca acacagctaa aacgacttca
     1861 gaaacatacg gtcttgataa agactacctt gcaggagcta acattgctgc ctttgaaaat
     1921 gtagcaaatg ccatgattgc acaaggtatt gtttaagatt tatttactca atcctcaatc
     1981 actacgattg gggattttta gcttgaatta aaaaattgga aaatctaatt aaataaaatg
     2041 aaatgaaata aaaactgaac aaattgattg cggaattcaa accaatttct aacatacttc
     2101 tagaaattaa tttgactttt ctaatcgatt tgttcatatc ttatttcaat ttactatact
     2161 tacttaaccc tttttatact caatgaaaat caaagagcaa actaggaagc gagccgcagg
     2221 ctgtacttga gtacggcaag gcaaagctga cgtggtttga agagattttc aaagagtatt
     2281 aaacaaaaag aaaaaccgct actcctaaga atagcgattt aatcatgttt ttaagctact
     2341 actgtagttg ctctattatt taagtgttat gaataacttc aatatcttta aagctttttg
     2401 ttagatttat aatttcaact atagccatct ctactcctta gtttacagca aaaaattatg
     2461 cttaattctt attgtttttg taaacaatca gcgaacccaa tactattcca ttcaacaagc
     2521 ctaaagaaat accatattca actggaaaat ctaaaaaaat tgcaaacact attccaatca
     2581 tcacccctag tgaggctgtt gttaaaatta catattcatt ttctttcttc attttcttta
     2641 cacctcattt cctttttgta tataagctgt agtactctcc accaagctcc attaagtact
     2701 tatgatttcc tgactcaaca atcttaccac ctttcattac aaaaataata tccgcatcct
     2761 taatcgttga caatctatga gctacaatta tttgagtaca gccctgactt tttatatact
     2821 ttgttattct ttcctcatta atagtgtcta aagcactagt tgcttcatct aaaattacaa
     2881 tactaggatt atttattaat gcacgtgcca gtgctatccg ttgtctttga ccacctgaaa
     2941 tatttgaacc catctctgag atgatagtat taaatttcat cggcatagcc atgatttcat
     3001 catagatttg aactgcttta caaacttcct ctatcttttg tgaagtaact tcgttcttta
     3061 aagttatatt atcaagaata cttcggttca ataaaaatga atcctgtgga actactccta
     3121 aattttgact taatattttt ttatctattt gattaatatt tataccatca aataaaactt
     3181 ttcctgtatc aatcttatat aatcctgatg gtatttttga taatagactt cctgcaaaac
     3241 tagaatccta gttcatgatt gataatacca gcactcaaat tcattcgtaa tccaaagcgt
     3301 ttacgatgat ttcgataggt tgttgaaaac attttaaacg tttttacttt ggcaaagatg
     3361 ttctcaacct tgcttctatc cttagatagt gcatggttat aggttttatc ttcaactgtt
     3421 agcggcttga gtttgctgga tttacgtgga
//
LOCUS       DBMVGT010000114         3418 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.114, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000114 DBMVGT010000000
VERSION     DBMVGT010000114.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3418)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3418)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3418
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.114"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1252
                     /locus_tag="AC0DU4_002038"
     CDS             join(<1..342,342..1252)
                     /locus_tag="AC0DU4_002038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611513.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HIN4237940.1"
                     /translation="LKYMVKLIDRYGIEIVKKGKNRHYSSKLKQEMMDKALLEGCSQR
                     SISLDYALPNQGMLSFWPAQYKKNGYTIVEKTRGRPAKMGRKRKKTWEEMTELERLQE
                     ENERLRTEVAYPKKVKRVRGKGRSPRARKAETVREMVSGGFRLDFLLETARLARSTYY
                     YQLKQLDGVDKDKEIKTEIQGIDNEHKGNYGYRRIHLELRNRGFVVNHKKVQRLMRIL
                     GLTARIRRKRKYSSYQGEIGKKAENLIQRQFEASRPMEKCYTDVTEFAIPNSTQKLYL
                     SPVLDGFNSEIIAYHLSTSPNLEQVKSMLEQAFTEKYYENTILHSDQGWQYQHDSYHR
                     FLESKEIQASMSRKGNSPDNGMMESFFGILKSEMFYGYEKNFRSLENLEQAIVDYIDY
                     YNNKRIKVKLKGLSSVQYRTKSFG"
     gene            complement(1487..2095)
                     /locus_tag="AC0DU4_002039"
     CDS             complement(1487..2095)
                     /locus_tag="AC0DU4_002039"
                     /inference="COORDINATES: protein motif:HMM:NF016726.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF624 domain-containing protein"
                     /protein_id="HIN4237941.1"
                     /translation="MQIKFIDKVSNLIMLNLLYVASVVTVIAIGSGESALIATLIKIV
                     RHEESYPYRDFANSFFKDYWKNLGAALISNLPILILLFSLFFLPYIPLPIYIISILRH
                     IGVIYIILHLIATTFLIPLIGRYNNTLKNSLHNSIMLAYKHFFIAVLIRIIEIIPVLL
                     FFILQNQLLVWITLMIFILPSITKYANAFLYNFIFSKYEKLN"
     gene            2273..3031
                     /locus_tag="AC0DU4_002040"
     CDS             2273..3031
                     /locus_tag="AC0DU4_002040"
                     /inference="COORDINATES: protein motif:HMM:NF013539.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HIN4237942.1"
                     /translation="MADYILVRDSEIVYETSSEIVSKVKVGEGTLNRFCKKIGYSGFQ
                     ELKLKMTKDILELESQKMSSDTFIDEIKNNYLSIVESTRKLIDGRQIELAIKLIREAN
                     QILMIGVGSSGNAAREFESSLLRIGIISKTVIDTHFQLMHTALLKDNDLIIAFSLSGS
                     TKEVEETLLNAKRKNVKIISITNYSSRNIAKLSDCVLLTSKKESYLEGGSLMAKASQL
                     FIIDVICTRLSLINYEDTICKKEEIASLLSNKVE"
BASE COUNT         1295 a          434 c          605 g         1084 t
ORIGIN      
        1 gtctaaagta catggtgaaa ttaattgacc gttatggcat agaaatcgtt aaaaaaggga
       61 agaatcgtca ctattcttct aaattgaaac aagaaatgat ggataaagcc ttactggaag
      121 gttgttcaca aagaagtatt agtcttgatt atgccctccc aaaccaagga atgctttcat
      181 tttggccggc acaatacaag aaaaacgggt atactattgt tgagaaaaca agagggagac
      241 cagctaaaat gggacgtaaa cggaagaaga cttgggaaga aatgacagaa ctagaacgac
      301 tccaggagga gaatgaacgc ttacggactg aggtggccta cctaaaaaag ttaaaagagt
      361 tagaggaaag ggacgaagcc ctagagcgag aaaggcagag acagttagag aaatggtttc
      421 aggaggattt cgactagatt ttcttcttga aacagcacgt ttagctcgct cgacttacta
      481 ttatcagttg aaacaactgg atggggttga taaagataaa gagattaaaa ccgaaattca
      541 gggcattgat aatgaacata aaggcaacta tggctatcgt cgaatccatt tagaactaag
      601 gaatcgtggt tttgtggtca atcataagaa agttcaacgg ttgatgagaa ttcttggttt
      661 aacggctcga attcgccgta aacggaagta ttcttcctac caaggagaga ttggcaagaa
      721 agcagagaat ctcattcaac gccagttcga agcatcgagg ccaatggaaa agtgctatac
      781 agatgtgaca gagtttgcca ttccaaatag cacacagaaa ctctatttat caccagtttt
      841 agatggtttt aacagtgaaa tcattgctta tcatctttct acttcgccaa acttagaaca
      901 agtgaagagt atgttagaac aggcctttac agagaaatac tatgagaata cgattctcca
      961 tagtgaccaa ggctggcaat accaacacga ttcttatcat cggttcctag agagtaagga
     1021 aattcaagca tccatgtcac gcaagggcaa cagcccagac aacggcatga tggaatcttt
     1081 ctttggcatt ttaaaatccg aaatgtttta tggctatgag aagaacttta gatctttaga
     1141 aaaccttgaa caagctattg tggactacat tgattactac aacaacaaac gaattaaggt
     1201 aaaactaaaa ggacttagtt ctgtgcagta cagaactaaa tcctttggat aaattatttg
     1261 tctaattttt tggggtcagt acagtattaa ataccatgat cttatgcgtt ttataataaa
     1321 aaatctgttc ttgttttatt tttagaaaat ttactaaaga ctaaaaatat tatgaataat
     1381 ttaaaaaata gtcaggttat atagtttttt gaaattaaaa ttattttatc gttgaaatta
     1441 gttaaaaatt tttataaaat caagatgcaa ggctatgaga tgttctctag tttaattttt
     1501 catacttcga gaatataaag ttatataaaa atgcattagc atattttgtt attgagggaa
     1561 gtataaaaat cattaaagtt atccaaacta gtaattgatt ctgtaatata aagaagagta
     1621 gaactgggat aatttcaata attctaataa gaacggcaat aaaaaaatgt ttataggcta
     1681 acatgattga attgtgtaga gaatttttta aagtgttatt atatctaccg attaaaggaa
     1741 ttagaaatgt tgttgctatt aaatgaagta tgatatatat tactccaata tgtcgtaaga
     1801 tagaaatgat atatataggt aatggtatgt agggtaggaa gaacaaactg aataataaga
     1861 ttaaaattgg taaattagat attaatgctg ctcctaaatt tttccaataa tctttaaaaa
     1921 aactgtttgc gaagtctcta tagggatagg attcctcgtg tcgtacaatt tttattagag
     1981 ttgctattag ggcactttca cctgatccga tagcaataac tgttactact gacgctacat
     2041 agagtagatt taacattata agatttgaaa ctttatcaat aaattttatc tgcatcttta
     2101 actcctgctg tttttatact tataatatca catcatttga gtttcatcaa ctttgaatac
     2161 attaagaaag aatataacta tgaggaaagg aaaaaattat tatgaataaa tccaaaaaat
     2221 ataaagaaag aattcattat gaatacgata atcttactaa atcagagaaa aaattgctga
     2281 ctatatttta gttagagata gtgaaatagt ttatgaaacg tcttcagaaa ttgttagtaa
     2341 agtaaaagtt ggagagggaa ctcttaatcg attttgcaaa aagattggat actctggttt
     2401 tcaggaacta aaattaaaaa tgacgaaaga tatattagag ttagaatctc aaaaaatgag
     2461 tagtgacaca tttattgatg aaataaaaaa taattattta tctattgtgg aaagtacaag
     2521 aaaattaatt gatggtagac aaatagaatt agctataaaa ttaataagag aagcaaacca
     2581 gattttaatg attggtgtgg gttctagtgg aaatgcggct agagaatttg agagtagttt
     2641 gttaagaatt ggaataataa gtaagacggt aattgatacc cattttcaac tcatgcatac
     2701 tgcgttattg aaagataatg atttgataat agcgtttagt ttatctggtt ccacaaaaga
     2761 agttgaggaa actttattaa acgcaaaaag aaaaaatgtt aaaattattt caataacaaa
     2821 ttattcgtcc agaaatatag caaaattatc tgactgcgtt cttttgacat caaaaaaaga
     2881 atcttattta gagggtggta gtttaatggc taaggcttct caactattca taattgatgt
     2941 aatatgcact agactctctt taataaatta tgaagatact atatgtaaaa aagaagagat
     3001 tgcttctttg ctgtcaaata aagtggaata aatcaataat ttttaaattt taataaaaat
     3061 tttttaaaat aaattaaaaa acgatcctaa aagggtcgtt tttttgctaa agttttaaaa
     3121 ataaacaata attaagatta tagtgcgttg aatctatatt aggacataac aattcttaaa
     3181 tcattgttag aaattagttt gaatttccca atcaatttgt tcgattttta catcattgca
     3241 ttatatcatg tgactattaa ccttgttttc tcctaaaatt gattttcttc ttttcttatc
     3301 ttgtccactc gaaacaagta ttgtaagaat ttgattattt ttgaaagtac ttttaatata
     3361 tttgagatag ttaaaaaaga tttgaaacta aattccaaat tagaaaaaga cttgaaat
//
LOCUS       DBMVGT010000115         3384 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.115, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000115 DBMVGT010000000
VERSION     DBMVGT010000115.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3384)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.115"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..97)
                     /locus_tag="AC0DU4_002041"
     CDS             complement(<1..97)
                     /locus_tag="AC0DU4_002041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
                     /protein_id="HIN4237943.1"
                     /translation="MNYEASKQLTDARFKRLVGVQRTTFEKILAVL"
     gene            240..551
                     /locus_tag="AC0DU4_002042"
     CDS             240..551
                     /locus_tag="AC0DU4_002042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237944.1"
                     /translation="MELKDFTEKEQEMIKKRLTMSNISDKETTEKILALVPQDLIKRI
                     PFFVRKHATTRTIKRISIEYPELYAVAQTSGEIPEKKREELRQIITTIFEQKMNKHSI
                     K"
     gene            555..1271
                     /locus_tag="AC0DU4_002043"
     CDS             555..1271
                     /locus_tag="AC0DU4_002043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HIN4237945.1"
                     /translation="MKKYFIGGLGSNAYHSKDFLQELDSQVYFLNPYEKHLRDETELK
                     SWFKNEIVEEESICLIGHSLGGDLARYFASEFEEVKKLILLDGGYLDLDKILPLDTEL
                     EETKNYIKSQIVSDLDVLTSKEKSEAKHWSENMEKAVRQSYHWNVEYNRYELAINYEN
                     IEAILRLRRKIQAFKREVGDTLFISPRYPNEATWREEALKELPDYFDTIFLENFGHEL
                     YTQAPKEIASLMNEWLAYFL"
     gene            complement(1400..2215)
                     /locus_tag="AC0DU4_002044"
     CDS             complement(1400..2215)
                     /locus_tag="AC0DU4_002044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03943 family putative permease subunit"
                     /protein_id="HIN4237946.1"
                     /translation="MIRFLVLAGYFELTIYLHLSGKLNQYINMHYSYLAYISMVLSFI
                     LAIVQLYIWMKQVKTHSHLNSRLAKMTSISLLAIPLVIGLTFPTVSLDSQTVSAKGYH
                     FPLSEGTDLAIQTSEGTTSQYLKPDTSSYFSKSAYEKEMRTAADKYLSQDSIQITNEN
                     YMEVMEAIYDYPDEFEGKTIQFTGFVYNDPSHANSQFLFRFGIIHCIADSGVYGLLTK
                     GNTRQYENNTWITAKGKLVNHYHKELKQNLPTLEIDSFTKVDKPENPYVYRAF"
     gene            complement(2212..3117)
                     /locus_tag="AC0DU4_002045"
     CDS             complement(2212..3117)
                     /locus_tag="AC0DU4_002045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HIN4237947.1"
                     /translation="MTAFQQLPSSVLQTGAIFLSIIIEALPFVLIGSIVSGLIEVYIT
                     PDKVYHFLPRNRWGRIFFGTFVGMFFPSCECGIVPIINRFLEKKVPSYTAVPFLVTAP
                     VINPIVLFATYSAFGNSFHVALLRALGSILVAVILGIFLGFFWQEPIQKENRLACHEH
                     DFSYLSSAKKVFQVFVQAIDEFFDTGRYLVFGCLFASIIQVYVPTRILTSISATPLFA
                     ILLLMILAFLLSLCSEADAFIGASLLSSFGLAPVLAFLVIGPMLDIKNILMMKNYLKA
                     RFISHFITIVTLVVLVYSLLIGVIL"
     gene            complement(3118..3249)
                     /locus_tag="AC0DU4_002046"
     CDS             complement(3118..3249)
                     /locus_tag="AC0DU4_002046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245481.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPJ_0845 family protein"
                     /protein_id="HIN4237948.1"
                     /translation="MAVKFTKRDDLDKMFEEFAKLPDLKQVTFPDDKEKKAKAEKKN"
BASE COUNT         1129 a          580 c          695 g          980 t
ORIGIN      
        1 ttaatacagc taatatcttt tcaaaagtcg tgcgctgaac accaacaaga cgtttaaatc
       61 gtgcatcagt tagttgttta cttgcttcat aattcataga actactatac catattttgt
      121 ttcgcaggaa gtctaatgct aaaatcttat cagtgagaag atttcttaaa gtttattctt
      181 tgtagtttca tctgtattag tacataattt aacttagaga aaataggagg actaatcgaa
      241 tggaattaaa agattttaca gaaaaagaac aggaaatgat taagaaaagg cttacaatgt
      301 ctaatattag tgacaaagaa actactgaga agattctggc gctagtccca caagacttga
      361 ttaagcgaat cccgtttttt gtcagaaaac atgctacaac acgtacgatt aaacgcattt
      421 caattgaata ccctgaactc tacgctgtag ctcaaacaag tggtgagatt ccagaaaaaa
      481 aacgcgaaga attgcgtcag attatcacaa ctatctttga acaaaagatg aataagcata
      541 gtattaagta gagaatgaaa aaatatttta ttggcggttt gggaagcaat gcctatcata
      601 gcaaggattt tcttcaagaa ctagattcgc aggtctattt tctaaatcca tatgaaaagc
      661 atcttcgaga tgaaacagaa ttgaaatcat ggtttaaaaa tgaaattgta gaggaagaat
      721 ctatctgtct gataggccat tctcttggag gagatttagc tcgttatttc gcatcggaat
      781 ttgaagaagt aaagaaactg attcttttgg atggtggcta tctagattta gataagattt
      841 tacctttgga tacagagtta gaggaaacta aaaattatat caaatctcaa attgtttcgg
      901 acttagatgt tcttacttct aaagaaaaat ctgaagcaaa gcattggtca gaaaatatgg
      961 agaaagctgt aagacagtct tatcactgga atgttgagta taatagatat gagttggcta
     1021 taaattatga aaatatagaa gcgatactcc gcctacggag aaaaatacaa gcttttaaga
     1081 gagaagtggg agataccttg tttattagtc ctcgctatcc taatgaagct acatggagag
     1141 aggaagccct aaaagaattg ccagactatt ttgatactat ttttttagaa aactttggcc
     1201 atgagcttta tactcaagca cctaaagaaa tcgctagtct aatgaatgag tggctcgctt
     1261 attttctatg agctacttgt attgctggga atggtataag atgaaaatct acaagtcact
     1321 aattttcata taacaaaaaa cgaacaggct ctttttctgt tattcagaag agaacttgtt
     1381 cgtttttatc ttgattttct taaaaagctc tatatacata gggattttct ggtttatcga
     1441 ctttggtaaa gctgtcgatt tccaaggttg gaaggttttg tttgagttct ttatggtagt
     1501 gattgaccag ttttcctttg gctgttatcc aagtgttgtt ttcatactgc cgggtattgc
     1561 ccttggtcag caatccatag acaccagaat ctgcgataca gtggataatg ccgaatcgga
     1621 acagaaattg actattggca tgactggggt cgttatagac aaagcctgta aactggattg
     1681 tcttgccctc aaactcatct ggatagtcgt agatagcctc catgacttcc atatagtttt
     1741 cattagtgat ctgaatacta tcttgggata agtatttatc cgccgccgtt cgcatttcct
     1801 tttcataggc tgattttgaa aaataagaac tggtatctgg tttcaaatat tggcttgtcg
     1861 tcccttcgct tgtctgaatg gctagatccg ttccttccga tagggggaaa tgataacctt
     1921 tagcagaaac agtctgagaa tccaagctaa cagttgggaa agttaagccg atgacaagtg
     1981 gaatagccag aagagaaata ctcgtcatct tggctaatcg gctgttcaga tgactgtggg
     2041 ttttgacttg cttcatccag atatacaatt gaacgatagc caagataaaa gaaagcacca
     2101 tggagatata ggccagatag gaatagtgca tgttgatgta ctggtttagt ttgcccgaca
     2161 gatggaggta aatagtcagt tcaaaatagc cagctaaaac taaaaatcga atcataggat
     2221 gactccaatc aagagagaat agactaagac gacaagagtt acaattgtta tgaagtgact
     2281 gataaatcgt gctttcaagt aatttttcat catgagaata tttttgatat ccagcattgg
     2341 accaatgacg agaaaggcca gaactggtgc caaaccgaaa ctcgagagaa gagaagcacc
     2401 tataaaggca tccgcctcac tacagagcga aagaagaaag gctaaaatca tcaagagcag
     2461 gatggcaaaa agaggggtcg cactgataga ggtcagaatc cgagtcggaa cgtagacctg
     2521 tattatagaa gcaaagaggc agccaaatac caaataacgc cccgtatcaa aaaattcatc
     2581 aatggcctgc acaaagactt gaaaaacttt ttttgcagaa ctcaagtaag aaaaatcatg
     2641 ctcatgacaa gccagacgat tttctttctg aatcggttct tgccagaaaa atcctagaaa
     2701 aattcctagt attacagcca caagaatgga acccagagct cgtaataggg cgacatggaa
     2761 ggagttgcca aaggcagaat aggtcgcaaa aagaacaatg ggattgataa caggtgctgt
     2821 cacaagaaaa ggaacggccg tgtaacttgg aacctttttt tccagaaaac gattgatgat
     2881 ggggacgatt ccacattcac aagaagggaa aaacataccg acgaaggtcc caaaaaagat
     2941 tctcccccaa cgatttcgag ggagaaaatg ataaaccttg tcaggtgtga tataaacttc
     3001 aatcagccct gagacaatgc ttcctatcag aacgaaggga agggcttcaa tgataatgga
     3061 gagaaaaatg gctccagttt gaagtacact agatgggagt tgttgaaaag cagtcatcta
     3121 gtttttcttt tctgctttgg cttttttctc tttgtcatca gggaaagtaa cttgtttcaa
     3181 atcagggagt ttagcaaact cttcaaacat cttgtccaag tcgtctcgtt ttgtaaattt
     3241 tacagccata ggtgtacctc gattctaaat tctacctcta ttatactatt attttgcgga
     3301 aaagggagtt ttttaatttg ttttcgatag ttgatactct tcgaaaatct cttcaaacca
     3361 cgtcagcttc gccttaccgt agta
//
LOCUS       DBMVGT010000116         3322 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.116, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000116 DBMVGT010000000
VERSION     DBMVGT010000116.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3322)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.116"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(189..800)
                     /gene="rpsD"
                     /locus_tag="AC0DU4_002047"
     CDS             complement(189..800)
                     /gene="rpsD"
                     /locus_tag="AC0DU4_002047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_function: GO:0019843 - rRNA binding [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HIN4237949.1"
                     /translation="MSRYTGPSWKQARRLGLSLTGTGKELARRNYVPGQHGPNNRSKL
                     SEYGLQLAEKQKLRFTYGVGEKQFRNLFVQATKIKGGILGFNFMLLLERRLDNVVYRL
                     GLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSLKVPAILEAVEATL
                     GRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML"
     gene            complement(995..2047)
                     /locus_tag="AC0DU4_002048"
     CDS             complement(995..2047)
                     /locus_tag="AC0DU4_002048"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000769768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="HIN4237950.1"
                     /translation="MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTI
                     VASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDFPSNLEVQGPVEFQQLGQTFNEM
                     SHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLA
                     TIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERR
                     DVHLQVIPESARIEGDYAKLSRILVNLVDNAFKYSAPGTKLEVVAKLEKGQLSISVTD
                     EGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQLGGEITVSSQYGLG
                     STFTLVLNLSGSENKA"
     gene            complement(2044..2742)
                     /locus_tag="AC0DU4_002049"
     CDS             complement(2044..2742)
                     /locus_tag="AC0DU4_002049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000520636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HIN4237951.1"
                     /translation="MGKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKK
                     KPIDLIITDVMMPRMDGYDLISEVQYLSPEQPFLFITAKTSEQDKIYGLSLGADDFIA
                     KPFSPRELVLRVHNILRRLHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFEL
                     LWILASNPERVFSKTDLYEKIWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTV
                     WGLGYKIEKPRGQT"
     gene            complement(2909..>3322)
                     /locus_tag="AC0DU4_002050"
     CDS             complement(2909..>3322)
                     /locus_tag="AC0DU4_002050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SSURE domain-containing protein"
                     /protein_id="HIN4237952.1"
                     /translation="ATVNVYGNKDGKPDLDNIVATKKVTIKINVKETSDTANGSLSPS
                     NSGSGVTPMNHNHATGTTDSMPADTMTSSTNTMAGENMAASANKMSDTMMSEDKAMLP
                     NTGETQTSMASIGFLGLALAGLLGGLGLKNKKEEN"
BASE COUNT          925 a          746 c          633 g         1018 t
ORIGIN      
        1 ccataaaaga ttataccaca ttgtgtacta tttttggttc attttactat atcactttgg
       61 actatatcgg tctagttatg tctaaacgat tatagctgga tactaagaga aatcaaaaaa
      121 gcactaaggg agaacgtccc aaagtgctta gtttcaaggc tttacagcct atcttattta
      181 ataaaatatt acaacatttt gttgtagaat tcaacgacaa gtgcttcgtt gatttctggg
      241 ttgatttcgt cgcgttctgg caagcgagtc aatgaacctt ccaatttttc agcgtcgaat
      301 gatacgaatg ctggacgtcc aagagtagct tctactgctt caaggattgc tggaactttc
      361 aatgattttt cacgaactga gatcacttga cctggagtta cgcggtatga tgggatatca
      421 acgcgtttcc cgtcaacaag gatgtgaccg tggtttacaa attgacgagc ttgacgacga
      481 gtagtcgcga gaccaagacg gtaaacaacg ttatccaaac gacgttccaa aagaagcata
      541 aagttgaaac ctaggattcc gcctttgatt tttgtagctt gtacaaacaa gttacggaat
      601 tgtttttcac ctacaccgta agtgaaacga agtttttgtt tttcagccaa ttgcaaaccg
      661 tattctgaca atttagaacg gttgtttggt ccgtgttgtc ctggtacgta gttacgacgt
      721 gccaattctt tacctgtacc tgtaagtgaa aggccaaggc gacgagcttg tttccaagat
      781 ggtcctgtat aacgtgacat atgaatgtcc tcctgatata aataatattt cggtggaaat
      841 agtcacttag aaagccctga ttcgtgcaga tgcccttcgc ctaaacagcc aaggttactt
      901 atcataagac acctgttgac gagcttcatg ctttcctgct gatatttcac acaaaattca
      961 ttctaccatg aatagctgga tttgtaaagg ggttttaggc tttattttca ctaccagaga
     1021 ggttgagaac gagagtaaag gtacttccta gaccgtactg gctgctgact gtgatttccc
     1081 cacccaattg atgggccaat tcacgcgcaa tcgcaagtcc taatccatga ccacctgtct
     1141 tcatgttacg cgaagtttcg acacgataaa ggcgtttgaa aatattttcc aaatcctctg
     1201 gggcaatgcc ctgcccttca tcggtcacac tgattgaaag ctggcccttc tccagcttag
     1261 ccaccacttc cagcttggtt cctggagcag aatatttaaa agcgttatcg accagattca
     1321 ccaagatacg agaaagctta gcataatctc cctcaatccg ggcagactct gggattacct
     1381 gcaagtggac atctcttctc tcctgctcaa tcaaaaactg aaattcactc atgcactcaa
     1441 ttaagagctt gtccagaaaa atactgtctt tactggtagt ttccacctga tttctagctg
     1501 tgtttagggt caaaaaattc aactcctcaa ccagtttatt gagcctctcc gtctggcgtc
     1561 caatggttgc tagataatga gcttgctccg actccttgat aatcccatcc aaaatccctt
     1621 ctaccgtcgc ttggatcgaa gtgataggag tcttaatatc atgcgacaac tgagcaatca
     1681 tcaagccctt ttctcgttcg ctttcttcca aggaatcaaa gcttacctgc aaatcatggg
     1741 acatctcatt aaaagtttgc cctaattgct gaaattctac aggaccttga acctccaaat
     1801 ttgaaggaaa atccttggcc gctacccgct tggcatgctc cttgagtttg cccaacgacg
     1861 taaagactgg caataggaga aagagactaa tcccagcacc gacaaggctg gcaacgatgg
     1921 tcatcccaag caaaaagtaa atctcgcctt tcgcaatcag cattttttga acagcccaaa
     1981 aaacaaccaa aatggttaag agggttgaaa taatatatcc aaccaaaata taacttttta
     2041 gtttcatgtt tgtcctctcg gtttctctat cttatatccc aacccccaaa ctgtcttaat
     2101 agtgggcgtt tggtcactac tatattttgc cagctcctgt cgaagagcat ggatatgcac
     2161 attcaaggta ttggtgtcat ccacgtagtc ttctttccag atcttttcat agaggtctgt
     2221 cttggagaaa actcgctctg gattgctagc taaaatccac agcaattcaa atgatttaac
     2281 agttaaatcc agcatttctt ctcctatttg aacttcatga ctactatgat tcatttttag
     2341 attgccaagg gaaatcagct ctgtttcgcc cccacgatga aggcggcgca aaatattgtg
     2401 gacacgcaaa actagctcac gtgggctaaa aggcttagca ataaaatcat ctgctcccaa
     2461 gctcaggccg taaatcttgt cctgctcact ggtcttagca gtaataaata ggaaaggctg
     2521 ctctggtgat aagtattgaa cctcactgat taaatcataa ccatccatcc gaggcatcat
     2581 gacatctgtg ataatcaaat caatcggttt tttcttgaac agctctagcg cttccagtcc
     2641 atcatgggct accaagacct gataacctgc ctgaattaag tatctctgat gaatatctgt
     2701 gatttctacc tcgtcgtcaa cgagtaaaat tgtctttccc atctgtctct cctttgataa
     2761 aaacagtgct atactgcttt aagtataaca ctatttttat tgttttacga tgattttaat
     2821 ctgctattga aagaaagtcc tgattgctga ttgagttgtt aaactaatct tagtcagccc
     2881 actatccatc atttatttcc ttagctgatt agttttcttc ttttttgttt ttcaaaccta
     2941 gaccaccgag taaacctgca agcgcaagcc caaggaaacc aatacttgcc attgatgttt
     3001 gagtctcacc agtatttggt agcatagctt tatcctctga catcatcgta tcagacatct
     3061 tgttagcaga agcagccata ttttcacctg ccatcgtgtt ggtagaactt gtcatggtgt
     3121 cagcaggcat gctatctgta gtacctgtag catgattgtg attcatcgga gtcacgccag
     3181 aaccagagtt agaaggtgat aatgaaccat ttgctgtgtc tgatgtttct ttaacattta
     3241 tcttaatagt gactttttta gttgctacga tgttgtccaa gtctggttta ccgtctttgt
     3301 taccatagac attgactgta gc
//
LOCUS       DBMVGT010000117         3304 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.117, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000117 DBMVGT010000000
VERSION     DBMVGT010000117.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3304)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3304)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3304
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.117"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..2037
                     /locus_tag="AC0DU4_002051"
     CDS             <1..2037
                     /locus_tag="AC0DU4_002051"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HIN4237953.1"
                     /translation="RTTNEMLDEFAFLGEELARKLVIENTNALAEIFEPVEVVKGDLY
                     TPFIDKAEETVAELTYKKAFEIYGNPLPDIVDLRIEKELTSILGNGFAVIYLASQMLV
                     QRSNERGYLVGSRGSVGSSFVATMIGITEVNPLSPHYVCGQCQYSEFITDGSYGSGFD
                     MPHKDCPNCGHKLSKNGQDIPFETFLGFDGDKVPDIDLNFSGEDQPSAHLDVRDIFGE
                     EYAFRAGTVGTVAAKTAYGFVKGYERDYGKFYRDAEVERLAQGAAGVKRTTGQHPGGI
                     VVIPNYMDVYDFTPVQYPADDVTAEWQTTHFNFHDIDENVLKLDVLGHDDPTMIRKLQ
                     DLSGIDPNEIPMDDEGVMALFSGTDVLGVTPEQIGTPTGMLGIPEFGTNFVRGMVDET
                     HPTTFAELLQLSGLSHGTDVWLGNAQDLIKQGIADLSTVIGCRDDIMVYLMHAGLEPK
                     MAFTIMERVRKGLWLKISEEERNGYIEAMKANKVPEWYIESCGKIKYMFPKAHAAAYV
                     MMALRVAYFKVHHPIYYYCAYFSIRAKAFDIKTMGAGLEAIKRRMEEISEKRKNNEAS
                     NVEIDLYTTLEIVNEMWERGFKFGKLDLYRSQATEFLIDGDTLIPPFVAMDGLGENVA
                     KQLVRAREEGEFLSKTELRKRGGLSSTLVEKMDEMGILGNMPEDNQLSLFDELF"
     gene            2139..2402
                     /locus_tag="AC0DU4_002052"
     CDS             2139..2402
                     /locus_tag="AC0DU4_002052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB/DinJ family
                     antitoxin"
                     /protein_id="HIN4237954.1"
                     /translation="MSKMSMSIRLDSEVKEQAQQVFSNLGMDMTTAINIFLRQAIQYQ
                     GLPFDVRLDENRKLLQVLTDLDQNRNMSQSFESVSDLMEDLRA"
     gene            2395..2673
                     /locus_tag="AC0DU4_002053"
     CDS             2395..2673
                     /locus_tag="AC0DU4_002053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013904578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system YafQ family
                     toxin"
                     /protein_id="HIN4237955.1"
                     /translation="MLKIRYHKQFKKDFKLAMKRGLKAELLEEVLNFLVQEKEHPARY
                     RDHSLTASKHFQGVRECHTQPDWLLVYKVDKSELILNLLRTGSHSDLF"
     gene            2694..2846
                     /locus_tag="AC0DU4_002054"
     CDS             2694..2846
                     /locus_tag="AC0DU4_002054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237956.1"
                     /translation="MKLRIFAEDKPAKKVFEYQLELADRTILLSTALLSGAIALAGIF
                     SALKEK"
     gene            2868..>3304
                     /locus_tag="AC0DU4_002055"
     CDS             2868..>3304
                     /locus_tag="AC0DU4_002055"
                     /EC_number="3.4.11.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004177 - aminopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HIN4237957.1"
                     /translation="MVLPNFKENLEKYAKLLVANGINVQPGHTLALSIDVEQRELAHL
                     IVKEAYALGAHEVIVQWTDDVINREKFLHAPMERLDNVPEYKIAEMNYLLENKASRLG
                     VRSSDPGALNGVDADKLSASAKAMGLAMKPMRIATQSNKVSWTV"
BASE COUNT          927 a          599 c          837 g          941 t
ORIGIN      
        1 cgaacgacta atgagatgtt ggatgaattt gcctttttgg gagaggaact ggctcgtaaa
       61 ctggttattg aaaacactaa tgccttggca gaaatatttg aacccgttga agtcgttaag
      121 ggtgacttgt atacgccttt catcgacaag gctgaagaaa cagttgctga gttgacctat
      181 aagaaagctt ttgagattta tggaaatccg ctgccagata ttgttgattt gcggattgaa
      241 aaagaattaa catccatact ggggaatgga tttgctgtga tttatctggc atcgcagatg
      301 ctggtgcaac gttctaatga acggggttat ttggttggtt ctcgtgggtc tgtcggatct
      361 agtttcgttg cgaccatgat tgggattacg gaggtcaatc ctctctctcc tcactatgtc
      421 tgtggtcagt gtcagtacag tgagtttatc acagatggtt cgtacggttc aggatttgat
      481 atgccccata aggactgtcc aaactgtggt cacaaactca gtaaaaacgg acaggatatt
      541 ccgtttgaga ccttccttgg ctttgatggg gataaggttc ctgatattga cttgaacttc
      601 tcgggagaag atcagcctag cgcccacttg gatgtgcgtg atatctttgg tgaagaatat
      661 gccttccgtg cgggaacggt tggtacggta gctgccaaga ctgcctatgg atttgtcaag
      721 ggttacgagc gagattatgg caagttttat cgtgatgcag aagtagaacg cctcgctcaa
      781 ggagcggcgg gtgtcaagcg gacaacaggc caacacccgg ggggaatcgt tgttattccg
      841 aactacatgg atgtctacga ttttacgcct gtccagtatc cagcagatga tgtcacggct
      901 gaatggcaga ccactcactt taacttccac gatatcgatg agaacgtcct caaactcgat
      961 gtactgggac atgatgatcc gaccatgatt cgaaaacttc aggatttgtc tggtattgac
     1021 cctaatgaaa ttcctatgga tgacgaaggc gtgatggcac tcttttctgg gactgatgtg
     1081 ctaggggtaa cacctgaaca aattggaacg cctacgggta tgttggggat tccagagttt
     1141 ggaacaaatt tcgtacgtgg aatggtagac gaaacccatc cgacaacctt tgcggaattg
     1201 cttcagctgt ctggtctgtc ccacggtact gacgtttggt tggggaatgc tcaggatctg
     1261 attaagcaag gaatagcgga cctatcgact gttatcggtt gtcgggacga catcatggtt
     1321 tacctcatgc atgcgggtct ggaacctaag atggccttta ccattatgga acgggtacgt
     1381 aagggtttgt ggctaaagat ttcagaagag gagagaaatg gctatatcga agccatgaag
     1441 gctaataagg tgccagagtg gtatatcgaa tcctgtggga aaattaagta catgttccct
     1501 aaggcccatg cggcagccta cgttatgatg gccttgcgtg tagcttactt caaggttcac
     1561 catcctattt attactactg tgcttacttc tccattcgtg ctaaggcttt tgatatcaag
     1621 accatgggtg cgggcttgga ggccatcaag cgcagaatgg aagaaatctc tgaaaaacgg
     1681 aagaacaatg aagcctctaa tgtggaaatc gatctctata caactcttga gattgtcaat
     1741 gagatgtggg aacgaggttt caagtttggc aaattagatc tctaccgtag tcaggcgaca
     1801 gagttcctca tcgacgggga tacccttatc ccaccatttg tagcaatgga tggtctggga
     1861 gagaacgttg ccaagcaact ggtgcgggcg cgtgaagagg gagaattcct ctctaaaaca
     1921 gaactacgca agcgtggtgg actctcatca accttggttg aaaagatgga tgagatgggt
     1981 attcttggaa atatgccaga ggataaccag ttgagtttgt ttgatgagtt gttttaaaaa
     2041 attgcttaat aatctattag aagaggctaa cgtatatcca atagatttac attagctttc
     2101 ttttttgtta aaatagtcta tggaaagagg gtgagagtat gtcaaagatg agtatgagca
     2161 tccgtctgga tagtgaggtt aaggagcagg cccaacaggt gtttagtaat ctgggaatgg
     2221 atatgacaac agctattaat attttccttc gtcaggcaat tcaatatcag ggattacctt
     2281 ttgatgttag actagacgaa aatcggaagt tgctccaagt gttaacggat ttagaccaaa
     2341 atcgtaatat gagccagtct tttgaatcag tctcagattt gatggaggac ttacgtgctt
     2401 aagattcgtt atcataaaca gtttaaaaaa gattttaagt tggctatgaa gcgtggtttg
     2461 aaggcagaat tattagaaga agttttgaat tttctggttc aagaaaaaga acatcctgcc
     2521 agatatcgtg atcattcatt gacggcatcc aagcattttc aaggagttcg tgaatgccat
     2581 acccagccag attggctttt ggtttataaa gtagataagt cggaattgat tttaaatttg
     2641 ctgaggacag gcagtcacag tgatttattt taatctattt taagggggtt ctcatgaaac
     2701 taagaatatt tgcggaagat aagccggcta agaaggtatt tgaatatcaa ttagaacttg
     2761 ctgatcgtac aattctttta tcgacagcac tcttgtcagg tgctattgct ttagcaggaa
     2821 tcttttctgc tttgaaagaa aaataaaaat agaaaagaga aaacaggatg gttttaccaa
     2881 attttaaaga aaatctagaa aaatatgcga aattgttggt tgcgaacgga attaacgtgc
     2941 aacctggtca cactttggct ctctctattg atgtggagca acgtgaattg gcacatctaa
     3001 tcgtgaaaga agcttatgcc ttgggtgcgc atgaggtcat cgttcagtgg acagatgatg
     3061 tgattaaccg tgagaaattc ctccatgccc cgatggagcg tttggacaat gtgccagaat
     3121 acaagattgc tgagatgaac tatctcttgg agaacaaggc tagccgtctt ggagttcgtt
     3181 catctgatcc aggtgccttg aacggagtgg acgctgacaa gctttcagct tctgctaaag
     3241 ctatgggact tgccatgaag ccaatgcgaa tcgcaactca atctaacaag gttagctgga
     3301 ctgt
//
LOCUS       DBMVGT010000118         3266 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.118, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000118 DBMVGT010000000
VERSION     DBMVGT010000118.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3266)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3266)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3266
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.118"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..204
                     /locus_tag="AC0DU4_002056"
     CDS             <1..204
                     /locus_tag="AC0DU4_002056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0015267 - channel activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin"
                     /protein_id="HIN4237958.1"
                     /translation="TLIVGIGLSLGGTTGYALNPARDLGPRIMHSILPIPNKGDGDWS
                     YAWIPVVGPVIGAALAVLVFSLF"
     gene            395..598
                     /locus_tag="AC0DU4_002057"
     CDS             395..598
                     /locus_tag="AC0DU4_002057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237959.1"
                     /translation="MPKWSNPDYVNELDPKIVDMLVEFHKSQGTLETPEAQAEIAQKR
                     EEIEQRRAELEDKKQELLNRLNK"
     gene            complement(685..1293)
                     /locus_tag="AC0DU4_002058"
     CDS             complement(685..1293)
                     /locus_tag="AC0DU4_002058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237960.1"
                     /translation="MSSISPSLVVFADDSLSANSKVVSGEAQFENGSSVRFGDTQVNI
                     LSDEVLEVVNPDGSVDTIERRADGVYINGAFYMAYQKNEIDLNISFRSYDPNVWNYVN
                     TIHGNKQANTFANFMTGAGISYMIGRIGALLGGPWGAIIGGAYFGIQAYQSYLDSQSP
                     YPYYITSTYIHVAQRKWKFITEYYRNSDYTGYVKTVTTYVNF"
     gene            1425..1622
                     /locus_tag="AC0DU4_002059"
     CDS             1425..1622
                     /locus_tag="AC0DU4_002059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000930586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237961.1"
                     /translation="MLNAKIFYIFLCLIVIETTGLLLLKRGLEMGYLDTEAIILAVFS
                     FAFYNLCSFAWVCSTIKNNKK"
     gene            2324..>3266
                     /gene="ltrA"
                     /locus_tag="AC0DU4_002060"
     CDS             2324..>3266
                     /gene="ltrA"
                     /locus_tag="AC0DU4_002060"
                     /EC_number="2.7.7.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="HIN4237962.1"
                     /translation="MSKLLDKILSRENMLEAYNQVKSNKGSAGIDGMTIEEMDNYLRQ
                     NWRLTKELIKQRKYKPQPVLRVEIPKPDGGIRQLGIPTVMDRMIQQAIVQVISPICEP
                     HFSDTSYGFRPNRSCEKAIMKFLEYLNDGYEWIVDIDLEKFFDTVPQDRLMSLVHNII
                     EDGDTESLIRKYLHSGIIINGQRHKTLVGTPQGGNLSPLLSNVMLNELDKELEKRGLR
                     FVRYADDCVITVGSEAAAKRVMYSASRFIEKRLGLKVNMTKAKITRPGELKYLGFGFW
                     KSSDGWKSRPHQDSVRRFKLKLKKLTQRKWSIDLTRRI"
BASE COUNT         1082 a          619 c          675 g          890 t
ORIGIN      
        1 actttgattg tcggtatcgg tctatcacta ggtgggacaa caggttatgc cttgaaccca
       61 gctcgtgacc ttggacctcg tatcatgcac agcatcttgc caattccaaa caagggagac
      121 ggagactggt cttacgcttg gattcctgtt gtaggccctg ttatcggagc agccttggcc
      181 gtgcttgtat tctcactttt ctaatctaga aaacaattat gttgatagag cttgggcaag
      241 agcccaattt cagcaaaaaa tgaagtaaat cttctcataa taaaacgcat catatcaagc
      301 acgaaaattc cacgaggtca actacagtca gaaagctgaa caacaagcca aaacgcccaa
      361 aaaaggcggc aaaaagcaag cacctgcaag caacgtgccg aaatggtcaa atcctgatta
      421 tgtcaacgaa ttagacccaa aaatcgttga tatgctagta gaatttcaca agtcacaagg
      481 cactttggaa actcccgagg cgcaagcaga aatcgcccaa aaacgtgaag aaatcgagca
      541 aaggagagct gagcttgagg ataaaaaaca agagcttttg aaccgcttga acaaatagag
      601 tttcgcaagt attatgctta caaattactt gagcaattaa ctaaaatata aaccatgcct
      661 ttatatctag gcagggttta tattttagaa attcacgtag gttgttacgg tttttacata
      721 cccagtatag tctgagtttc tatagtattc agtgataaac ttccattttc tttgagcaac
      781 atggatataa gtacttgtta tgtagtatgg atatgggctt tgtgaatcca agtaagactg
      841 ataagcttgt ataccaaaat atgctccacc aattattgca ccccatggac cccccaataa
      901 agcacctatc ctaccaatca tataactgat tccagcacca gtcatgaagt tagcgaatgt
      961 gttagcttgt ttattcccat gtattgtgtt gacgtaattc caaacattag gatcgtatga
     1021 tctaaaagat atatttaggt caatttcatt cttttgataa gccatataaa atgccccatt
     1081 gatatagacg ccgtcagcac gtcgttcaat agtgtctaca cttccatctg gattgacaac
     1141 ctcaagaact tcatcgctta aaatatttac ttgcgtatct ccgaaccgca ctgatgagcc
     1201 attctcaaac tgagcctcac cagatacaac tttagagttt gccgataagc tatcatcagc
     1261 aaaaacaaca agcgacgggg aaatgctaga catacagaaa acagacataa ctagcaaaca
     1321 catgcattta agcatcttag acataacgga aactcctttg tatttttgat ttttttcaac
     1381 ttttattata caataaaacc aaataaaaag aaagcggtaa caatatgctt aatgcgaaaa
     1441 ttttttatat atttttatgt ttgatcgtta tcgaaactac aggcttgttg ttgttgaaaa
     1501 gaggtctcga aatgggttat ttagacacag aagctattat cctcgcagtt ttttcatttg
     1561 ctttttacaa cctatgttca ttcgcttggg tctgctctac aataaaaaac aataaaaaat
     1621 aaatagacgt attttcaaaa aaaaatgcat atttatctta gcagaacgac gatttaaatc
     1681 gtcgtttttt tgtagtacga cgggcatgtc gtatatctga ggtgtaagtc ctcggtgggc
     1741 acctgctacc ggtgaaccca atagcgattc tcaagcctga ctatcgtgag gtagcaggga
     1801 gaggaaggga tagcgaaatc gtggctctac gaacaggaac gtgatagtaa ggcgtatata
     1861 gcggataagg gggcctcaaa ctctaaagtc caaaaaggta gtcgtaacct atatgcgtaa
     1921 atcacgagag taattgaatt cggactaagg tttgtgtgaa aaagataaat ctttctagcg
     1981 tctaaagact ctgcgtcaga tttcctattt tcactgtaac cttttaacgt cctcatatct
     2041 tgtataaacg aggaaagatg tacgacttat cccgtgaggt ctcatgagcg ctgaaagcgt
     2101 agtaacaacg aatcatgaga agtcagccga acccatagta gtgaggaaac ttctgtaatg
     2161 gaagtggagc gaaggggtga acaactaatt gaagtaatcc tacttcactt gtgtctgtaa
     2221 aacgagaggt ctgatagaac tggagtctgt cacgtattga ctagatgaag gctcaccaat
     2281 ataagatgtc cctcaggcac caaaacaaga aaggaatacg cacatgtcaa aattgctaga
     2341 taagatatta tcacgcgaaa atatgctgga agcctacaat caagtaaaat ccaataaagg
     2401 ctcagctggg attgatggaa tgactatcga agagatggat aattatctca gacaaaactg
     2461 gcgcttgact aaggaactga taaaacagag aaaatataag cctcaaccag ttcttagagt
     2521 tgagatacct aaaccagacg gaggcatccg tcaactagga attccaacag ttatggatag
     2581 aatgattcaa caggccattg tccaagttat tagtcccatt tgtgaacccc atttctcaga
     2641 tacgagttat ggcttcagac caaataggtc atgtgaaaaa gccatcatga agttcttaga
     2701 gtacttaaat gacggctatg agtggatagt ggatatagac ctagagaaat ttttcgatac
     2761 ggttcctcaa gatagattga tgtccttggt acataacatt atcgaagacg gagatacgga
     2821 atccctgatt cgtaagtatc ttcattcagg tattatcatt aatggtcagc gtcataaaac
     2881 gctagttggc acaccacagg gaggaaattt atctcctctc ttatccaatg tcatgcttaa
     2941 tgaattggac aaggaattag aaaagagggg acttcgattt gtgcgctacg cagatgattg
     3001 tgtgattacg gtcggaagcg aggcagccgc taagcgtgtg atgtattcag ccagtcgttt
     3061 tattgagaag cgactaggtt tgaaagtaaa tatgaccaag gctaagatta ccagaccagg
     3121 agagctgaaa tacttaggtt ttgggttctg gaaatcatca gatggttgga aaagtcgtcc
     3181 ccatcaagat agtgttcgga gatttaagct taaattgaag aaactaacac agaggaaatg
     3241 gagtatagac ttaacaagac gtattg
//
LOCUS       DBMVGT010000119         3151 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.119, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000119 DBMVGT010000000
VERSION     DBMVGT010000119.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3151)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.119"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..306
                     /locus_tag="AC0DU4_002061"
     CDS             <1..306
                     /locus_tag="AC0DU4_002061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
                     /protein_id="HIN4237963.1"
                     /translation="FKMSCRNIGQAGKILADSGYQGLMKIYPQAQTPRKSSKLKPLTA
                     EDKACNHALSKERSKVENIFAKVKTFKMFSTTYRNHRKRFGLRMNLIAGIINHELGF"
     gene            387..1103
                     /gene="ldcB"
                     /locus_tag="AC0DU4_002062"
     CDS             387..1103
                     /gene="ldcB"
                     /locus_tag="AC0DU4_002062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase LdcB/DacB"
                     /protein_id="HIN4237964.1"
                     /translation="MKKRYLVLTALLALSLAACSQEKAKNEDGAAKTEQTAKADGTVG
                     SKAQGAAQKKAEVVNKGDYYSIQGKYDEIIVANKHYPLSKDYNPGENPTAKAELLKLI
                     KAMQEAGFPISDHYSGFRSYETQTKLYQDYVNQDGKAAADRYSARPGYSEHQTGLAFD
                     VIGTDGDLVTEEKAAQWLLDHAADYGFVVRYLKGKEKETGYMAEEWHLRYVGKEAKEI
                     AASGLSLEEYYGFEGGDYVD"
     gene            complement(1143..1280)
                     /locus_tag="AC0DU4_002063"
     CDS             complement(1143..1280)
                     /locus_tag="AC0DU4_002063"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237965.1"
                     /translation="MKIKEQTRKLAAGCSKYSFEIADKTDEVSSKHCFEVVNRTDAVS
                     R"
     gene            1412..1837
                     /gene="rplK"
                     /locus_tag="AC0DU4_002064"
     CDS             1412..1837
                     /gene="rplK"
                     /locus_tag="AC0DU4_002064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004226069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HIN4237966.1"
                     /translation="MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNA
                     RTADQAGMIIPVVISVYEDKSFTFVTKTPPAAVLLKKAAGVEKGSGTPNKTKVATVTR
                     AQVQEIAETKMPDLNAANVESAMRMIEGTARSMGFTVVD"
     gene            2045..2734
                     /gene="rplA"
                     /locus_tag="AC0DU4_002065"
     CDS             2045..2734
                     /gene="rplA"
                     /locus_tag="AC0DU4_002065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HIN4237967.1"
                     /translation="MAKKSKQLRAALEKIDSTKAYSVEEAVALAKETNFAKFDATVEV
                     AYNLNIDVKKADQQIRGAMVLPNGTGKTSRVLVFARGAKAEEAKAAGADFVGEDDLVA
                     KINDGWLDFDVVIATPDMMALVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGK
                     ITYRADRAGNVQAIIGKVSFEAEKLVENFKAFNETIQKAKPATAKGTYVTNLTITTTQ
                     GVGIKVDVNSL"
BASE COUNT         1068 a          592 c          695 g          796 t
ORIGIN      
        1 ttcaaaatga gttgcagaaa tatcggacaa gctggtaaaa tcttggccga cagtggttat
       61 caagggctca tgaagatata tcctcaagca caaactccac gtaaatccag caaactcaag
      121 ccgctaacag ctgaagataa agcctgtaac catgcgctat ctaaggagag aagcaaggtt
      181 gagaacatct ttgccaaagt aaaaacgttt aaaatgtttt caacaaccta tcgaaatcat
      241 cgtaaacgct tcggattacg aatgaatttg attgctggta ttatcaatca tgaactagga
      301 ttctagtttt gcaggaagtc tattaaaaga ttagtcaaac gtttatcgtt agaagtagat
      361 aaactattag aaataaagga gtagaaatga aaaaaagata cctagtcttg acagctttgc
      421 tagccttgag tctagcagct tgttcacaag aaaaagcaaa aaatgaagat ggagcagcta
      481 aaacagaaca aacagctaaa gctgatggaa cagtaggaag taaggctcaa ggagctgccc
      541 agaaaaaagc agaagtggtt aacaaaggag actactacag catccaaggg aaatacgatg
      601 aaatcatcgt agccaataaa cactatccat tgtctaaaga ctacaatcca ggtgaaaatc
      661 cgacagccaa ggcagaattg ctcaaactca tcaaagcaat gcaagaggca ggtttcccga
      721 ttagcgatca ttacagtggt tttagaagtt atgaaactca gaccaagctc tatcaagatt
      781 atgttaacca agatgggaag gcagcagctg accgttactc tgcccgacct ggctatagtg
      841 agcaccagac aggcttggcc tttgatgtga ttgggactga tggtgatttg gtgacagaag
      901 aaaaagcagc ccaatggctc ttggatcatg cagctgatta tggctttgtt gtccgttatc
      961 tcaaaggcaa ggaaaaggaa acaggctata tggctgagga atggcacctg cgttatgtag
     1021 gaaaagaagc taaagaaatt gctgcaagtg gtctcagttt ggaagaatac tatggctttg
     1081 aaggcggaga ctacgtcgat taatactctt cgaaaatctc ttcaaaccac gtcagcgtcg
     1141 ccttacctac tgactgcgtc ggttctattc acaacctcaa aacagtgttt tgagctgact
     1201 tcgtcagttt tatctgcaat ctcaaagctg tactttgagc agcctgcggc tagcttccta
     1261 gtttgctctt tgattttcat tgagtataaa aaataaactt ttctcttgca attccagata
     1321 aatagtgtat aatggatggg tatgtgaaaa acatacttgt gggaggtaaa aatctctaat
     1381 taccgccaaa accacaaagg aggatttaaa aatggctaaa aaagtcgaaa aacttgtaaa
     1441 attgcaaatc cctgctggta aagctacacc agctccaccg gttggacctg ctcttggtca
     1501 agctggtatc aacatcatgg gattcacaaa agagttcaac gctcgtacag ctgaccaagc
     1561 tggtatgatc attccagttg ttatctcagt ttacgaagac aaatcattta ctttcgttac
     1621 aaaaacacca ccagctgctg ttcttttgaa aaaagctgca ggtgttgaaa aaggatcagg
     1681 tacacctaat aaaactaaag ttgctacagt tactcgtgca caagtacaag aaattgcaga
     1741 aactaagatg ccagatttga acgcagcaaa cgtagagtct gcaatgcgta tgatcgaagg
     1801 tactgctcgt tctatgggat tcactgttgt tgactaatca ataacacagt agaaaatctc
     1861 acagcagtct attagttgct tttcatacta ggcaagtgac tgagccttgt acttgggtac
     1921 agcaagggag cttaaggccg taggaagaga aaaatagtag actgaaaacc cgcaagactt
     1981 catcatttcg agaagtgacg tgggagatga aaatcgattg aaccacttac aaggagaata
     2041 gaaaatggct aaaaaaagca aacaacttcg tgctgctctt gagaaaatcg acagcacaaa
     2101 agcatacagt gtagaagaag ctgtagcact tgcaaaagaa actaactttg caaaatttga
     2161 cgcaactgta gaagttgctt acaacttgaa catcgacgtt aaaaaagctg accaacaaat
     2221 ccgtggagca atggtattgc caaacggtac tggtaaaact tcacgtgttc ttgttttcgc
     2281 acgtggtgca aaagctgaag aagcaaaagc tgctggtgca gactttgttg gtgaagatga
     2341 ccttgttgct aaaatcaacg acggttggtt ggacttcgac gtagttatcg ctacacctga
     2401 tatgatggct cttgttggac gtcttggacg tgtccttgga ccacgtaact tgatgccaaa
     2461 ccctaaaact ggtactgtaa caatggatgt tgctaaagca gttgaagagt ctaaaggtgg
     2521 taaaatcact taccgtgctg accgtgcagg taacgttcaa gcaatcatcg gtaaagtatc
     2581 atttgaagct gaaaaattgg ttgaaaactt taaagctttc aacgaaacaa tccaaaaagc
     2641 aaaaccagct acagctaaag gaacttacgt aacaaacttg actatcacaa ctactcaagg
     2701 tgttggtatc aaagttgacg taaactcact ttaatcagta gttaaagtaa tgtaaaaaag
     2761 ttgaagacac tatgtctcaa ctttttttga tgtacgacgg gcatgtcgta tatctgaggt
     2821 gtaagtcctc ggtgggcacc tactaccggt gaacccaata gcgattccca agtctgacta
     2881 tcgtgaggta gcggattaaa acggtctggg gatagaccgt tttaagtctg acgctggaaa
     2941 taagaatcgt cagaggaagg gatagcgaaa tcgtggctct acgaacagga acgtgataat
     3001 aaggcgtata tagcggataa ggtatctggc tggggcgacc actatcaatt ataataaaat
     3061 gaaataagaa taggacgaat cgttcaggac agtcaaatcg atttctaaca atgttttaga
     3121 agtagaggtg tactattcta gtttcaatct a
//
LOCUS       DBMVGT010000120         3135 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.120, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000120 DBMVGT010000000
VERSION     DBMVGT010000120.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3135)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3135)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3135
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.120"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            42..497
                     /locus_tag="AC0DU4_002066"
     CDS             42..497
                     /locus_tag="AC0DU4_002066"
                     /EC_number="3.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016817 - hydrolase activity, acting on
                     acid anhydrides [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0009132 - nucleoside diphosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HIN4237968.1"
                     /translation="MTQQDFRTKVDNTVFGVRATALIVQNHKLLVTKDKGKYYIIGGA
                     IQVNEKTEDAVVREVKEELGVKAQAGQLAFVVENRFEVDGVSYHNIEFHYLVDLLEDA
                     PLTMQEDEKRQPCEWIDLDKLEDIQLVPAFLKTALPDWEGQLRHIHLEE"
     gene            507..2420
                     /gene="mnmG"
                     /locus_tag="AC0DU4_002067"
     CDS             507..2420
                     /gene="mnmG"
                     /locus_tag="AC0DU4_002067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002098 - tRNA wobble uridine modification
                     [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HIN4237969.1"
                     /translation="MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEML
                     AFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQAD
                     KELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVTTGTA
                     LRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTE
                     IQPGDEAPNHFSYTSRDEDYVKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVG
                     PRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLSTSLPEDVQRDLVHSIKGL
                     ENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGI
                     NAALKIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMR
                     LTEMGREIGLVDDERWASFEIKKNQFDNEMKRLDSIKLKPVKETNAKVEEMGFKPLTD
                     AVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISKAMDQVAKMK
                     RMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEG
                     KNRSISKTLQKSK"
     gene            complement(2615..>3135)
                     /locus_tag="AC0DU4_002068"
     CDS             complement(2615..>3135)
                     /locus_tag="AC0DU4_002068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HIN4237970.1"
                     /translation="MPVHGEYRMQKVHAGLAVDTGVEKDNIFIMSNGDVLALTADSAR
                     IAGHFNAQDIYVDGNRIGEIGAAVLKDRRDLSEDGVVLAVATVDFKSQMILSGPDILS
                     RGFVYMRESGDLIRQSQRILFNAIRIALKNKDASVQSVNGAIVNAIRPFLYENTEREP
                     IIIPMILTPDEE"
BASE COUNT          879 a          667 c          782 g          807 t
ORIGIN      
        1 agttttgact gtttttgtgt cgtttaaggg aaaggacaag aatgactcaa caagactttc
       61 ggacaaaagt agacaatacg gtttttggtg ttcgggcgac agccttgatt gtccaaaatc
      121 acaagcttct agtcaccaaa gacaagggca agtattacat tatcggcggt gcgattcaag
      181 ttaacgaaaa aacggaagac gcggtagtcc gtgaagtgaa ggaagaactg ggtgttaaag
      241 ctcaagctgg gcagctagct tttgtggttg aaaatcgttt tgaagtggac ggcgtttcct
      301 atcacaatat cgagtttcat tatctggtgg atttgcttga agatgccccg ttgaccatgc
      361 aggaagatga gaaaaggcag ccctgtgagt ggattgactt ggataagctt gaggatatcc
      421 agctagttcc agccttttta aaaacagccc taccagattg ggaaggccaa ctaagacaca
      481 ttcatcttga ggaataggag agaaacatga cttatcattt tactgaagaa tacgatatta
      541 ttgtaattgg tgcgggacac gctggggttg aggcttcctt ggccgctagc cgtatgggct
      601 gtaaggtcct gcttgcgacc atcaatattg aaatgctggc tttcatgcct tgtaatccct
      661 ctatcggtgg ttctgccaag gggattgtcg tgcgtgaagt cgatgccctc ggtggcgaga
      721 tggccaagac tattgacaag acttacatcc agatgaagat gctcaacaca gggaaggggc
      781 cagctgttcg tgctcttcgt gcgcaggctg acaaggaact ttactctaag gaaatgcgca
      841 agacagttga aaatcaagaa aatctgaccc ttcgtcaaac catgattgat gagattttgg
      901 tggaagatgg taaggttgtc ggtgtgcgta cagccaccca tcaagaatat gctgctaagg
      961 ctgttattgt gacgacaggg actgctctcc gtggggaaat tatcatcgga gacctcaagt
     1021 actcatcagg tcctaaccac agcttggctt ctattaacct agctgacaat ctcaaggaac
     1081 tgggtctcga aatcggtcgt ttcaagacag gaacccctcc acgtgtcaag gcctcttcta
     1141 tcaactacga cgtgacagaa atccaaccag gagatgaagc acctaatcac ttctcataca
     1201 cttcacgtga tgaggattat gtcaaggacc aagtaccatg ctggttgacc tacaccaatg
     1261 gtaccagtca tgagattatc caaaacaacc tccaccgtgc gcctatgttt acaggtgtgg
     1321 tcaagggagt ggggcctcgt tactgtccgt cgattgaaga caagattgtg cgctttgcgg
     1381 acaaggaacg tcaccaactc ttccttgagc cagaagggcg caatactgag gaagtctatg
     1441 ttcaaggact ttcaaccagt ctgcctgagg atgtccagcg tgacttggtt cattccatca
     1501 aaggtttgga aaatgcagag atgatgcgga caggttatgc tattgagtat gatatggtct
     1561 tgcctcatca gttgcgtgcg actttggaaa ccaagaaaat ctcaggtctc ttcactgctg
     1621 gtcagacaaa tggaacatca ggttatgaag aagctgctgg ccaagggatt atcgcgggta
     1681 tcaatgcggc tctgaaaatc caaggcaagc ctgagttgat tttgaagcgc agtgacggtt
     1741 atatcggggt gatgatcgac gacttggtga ccaagggaac cattgaaccc taccgtctct
     1801 tgacaagtcg tgctgaatac cgtctcattc ttcgtcatga caatgctgat atgcgcttga
     1861 ctgagatggg acgcgagatt ggccttgtgg atgatgaacg ctgggctagt tttgaaatca
     1921 agaaaaatca atttgataat gagatgaaac gcctagacag tatcaaactc aagccagtca
     1981 aggaaaccaa tgctaaggtt gaggaaatgg gcttcaagcc gttgacagat gcggtgacag
     2041 ccaaggaatt ccttcgccgt ccagaagttt cttaccaaga tgtggtggcc ttcatcggac
     2101 cagctgcaga agacttggat gacaagatta tcgaattgat tgaaacagaa atcaagtacg
     2161 aaggctatat ttccaaagcc atggatcagg ttgccaagat gaaacgtatg gaagaaaaac
     2221 gcattccagc caatatcgac tgggatgaca tcgattctat tgcgacggaa gctcgtcaga
     2281 agttcaaact catcaatcca gaaaccatcg gccaagccag ccgtatttcg ggagtaaacc
     2341 cagcagatat ttctattttg atggtgtatc tggaaggtaa aaatcgtagt atttctaaaa
     2401 ctcttcaaaa atcaaaatga tacgtcgtcg gcttcttacg aatgagttca aagcttggct
     2461 ttgattcatc tccaacctcc catagttccc cgaactatgg gagctaactc aagttatgca
     2521 ttttcctagc cttctggtct gattttcatt gagttttaat ctcaaaagaa agcatagaga
     2581 aaaacagctc cgaagacggg gctgttttct tgctttattc ttcatctggt gtgaggatca
     2641 tcgggatgat gatcggttca cgttcggtat tttcatagag gaaggggcga atagcgttga
     2701 caatggcacc attgacagat tgcacgctag catccttatt tttcagtgcg atacgaatgg
     2761 cattgaagag gatacgctgg ctttggcgaa tcaagtcgcc agactctctc atgtagacaa
     2821 agcctcggct gaggatgtct ggaccagata gaatcatctg cgatttgaag tcaacagttg
     2881 cgactgccag aacgacaccg tcttcagata gatcgcgacg atctttgagg acagctgcgc
     2941 caatttcacc gatacgattt ccatcgacat agatatcttg ggcgttgaaa tgacctgcga
     3001 tacgagctga gtcagcagta agggcaagca catcgccatt gctcatgata aagatattgt
     3061 ccttctcaac accagtatcc actgctagtc cagcgtggac tttttgcatg cggtattcac
     3121 cgtggacagg catga
//
LOCUS       DBMVGT010000121         3134 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.121, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000121 DBMVGT010000000
VERSION     DBMVGT010000121.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3134)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3134)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3134
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.121"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..819
                     /locus_tag="AC0DU4_002069"
     CDS             <1..819
                     /locus_tag="AC0DU4_002069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4237971.1"
                     /translation="VARFSANASKSRQATSRKKMLDKIELEEIVPSSRKYPFINFKAE
                     REIGNDLLTVENLTVKIDGETILDNISFILRPDDKTALIGQNDIQTTALIRAIMGDID
                     YEGTVKWGVTTSQSYLPKDNSADFAGGESILDWLRQFASKEEDDNTFLRGFLGRMLFS
                     GDEVNKPVNVLSGGEKVRVMLSKLMLLKSNVLVLDDPTNHLDLESISSLNDGLKNFKE
                     SIIFASHDHEFIQTLANHIIVLSKNGVIDRIDETYDEFLENAEVQAKVKELWKD"
     gene            881..>3134
                     /locus_tag="AC0DU4_002070"
     CDS             881..>3134
                     /locus_tag="AC0DU4_002070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfhO family protein"
                     /protein_id="HIN4237972.1"
                     /translation="MKSFLKTYRTYFISFIIPVVIMSGVYLSQGIYWNSDNSPLLGDG
                     FHQYVIFDVALRNILHGNSSLFYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMP
                     DAIYLTTLLKFGLIGLSTFFSLNKLFQSIPQALKLALSTSYALMSFTVSQLEIKTWLD
                     VFILIPLIITGLHLLITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDF
                     KTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAK
                     QFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIE
                     ALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFL
                     ATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSL
                     NASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNY
                     NGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSLFGIQYNISDSPIDK
                     YGFKDIYQKDNLTLYENQYSLPIAVASQSVYNDVKFNEHTLDNQASFLNQLANVNFDY
                     FSPIPYEKTEKIENTNDLISITSSSNEDAAIQYQIEVPENSQVYLSFINLHFSNDKQK
                     KVDILVNGEKKTFTTDNVFSFFNLGYTKEKKTFNINVSFPGNSQVSFESPTFYRLDTK
                     TFTEAIQKIKE"
BASE COUNT          978 a          563 c          496 g         1097 t
ORIGIN      
        1 gttgctcgtt tctctgccaa tgcttctaag tcaaggcagg caacatcacg taagaaaatg
       61 cttgataaga ttgagctaga agagattgta ccatctagtc gtaaatatcc atttatcaac
      121 tttaaagcgg aacgtgagat tggtaatgat ctcttgacag tagaaaatct aactgtaaag
      181 attgatggtg aaactatctt ggataatatt agtttcatct tgcgtccaga tgataagaca
      241 gcacttattg gacaaaatga tattcaaacg actgcattaa ttcgtgcaat catgggagat
      301 attgactatg aaggaactgt caagtgggga gttacaacta gtcaatctta cctaccaaaa
      361 gataactcag ctgattttgc aggaggagaa tcaattcttg actggttgcg tcaattcgca
      421 agtaaagaag aagatgacaa tactttccta cgtggcttcc tcggccgtat gctcttctct
      481 ggagatgaag ttaacaaacc tgtaaatgtc ttgtcagggg gagaaaaagt tcgtgtcatg
      541 ctttcaaaac tcatgctctt aaaatcaaat gtccttgtac ttgatgatcc aacaaatcac
      601 ttggacttgg aatctatctc aagcttgaat gatggattga aaaactttaa agaatcaatc
      661 atctttgcca gccatgacca cgaatttatt caaactttgg ctaaccatat cattgtctta
      721 tctaaaaatg gcgtcattga ccgtatcgat gaaacctacg atgaattcct agaaaatgca
      781 gaagtacaag caaaagttaa agaactttgg aaagactaaa taaaacttca aaactcagtt
      841 gggttaacca actgagtttt ctatcattct acgaggtaac atgaaatcat ttttaaaaac
      901 atatcgaacc tattttattt ctttcatcat tcctgtagtg attatgtctg gagtatatct
      961 atctcaaggt atctactgga atagcgacaa ctctcctcta ttaggagatg gctttcatca
     1021 atacgttatt tttgatgtag ccttacgaaa tatcctacat ggaaatagta gtctgtttta
     1081 cacctttaca agtggtctag ggctaaactt ctatgcccta tctagttatt acttgggtag
     1141 ttttctcgcg cctctggttt acttttttga tctaacgaat atgccagatg ctatctatct
     1201 gacaactctc ttaaaatttg gattgattgg tctgtcaacc ttttttagtt tgaataaatt
     1261 gtttcaatct atccctcagg ctttaaaact agccttatct acttcctatg ctctgatgag
     1321 tttcactgtc agtcaattag agataaaaac ctggctagat gtttttatct tgattccttt
     1381 aattataact ggtttacatc tactgataac tgaaaagaaa ctcctattgt actttacaag
     1441 tctgtcaatc ttatttattc aaaattatta ttttggatat atgacagtat tgtttcttat
     1501 tttctggtat ctctgtcaaa tttcgtggga ctttaagact cgaaaatcat ctgttcttga
     1561 tttcatagtt atctcctttt tagctggtat ggctagtttg attatgactc ttcccactct
     1621 atttgattta cagacacatg gggaaaaatt gactgaagtt acaaagtttc aaactgaaag
     1681 tagctggtat cttgatctct ttgctaagca attcattggt tcctttgaca caacaaagta
     1741 tggggccatc ccaatgattt ttgttggact atttcccttt attttgacca ttttattttt
     1801 tacgctgaaa tctattaagt ttcacgtgaa actcatatat gtaatattct ttgcatttct
     1861 aattgcaagc ttttacatag aagctcttga cttattttgg caaggcatgc atactccaaa
     1921 catgttttta catcgctatg cttggatttt ctctaccttg ttaatttaca cagcagcaga
     1981 agtcttaaag cgtctgaaag aacttaaagt ctggaatttt ttagtttcgc tttttcttgt
     2041 agtagcagga tttttagcta ccatctatct aaaatcgcat tattcttttt taacagattt
     2101 gaatattctg cttactcttg aatttttggt tgtctattct cttttactcc ttgcagttat
     2161 caaaaagttt atatctgtga atctatttgc cattctaatc tctttattta tactggttga
     2221 aatgagttta aatgcttcat ctcaaatgga cggaattgct aaggaatggg gatttgcttc
     2281 tcgaagtgct tatagtcgag atatcccagc tatggaatct ttctcaacat atattggaaa
     2341 tcaatttact cgtactgaaa aactacaaac tcagacagga aatgacagta tgaaattcaa
     2401 ctacaatgga atctctcaat tttcatctgt tcgaaatcgt tcatcaagct ctactttaga
     2461 taaacttggt tttaaatcct ctgggactaa tctcaatctc cgatatgcaa ataatagtat
     2521 tttggctgat agtttatttg gtatccagta caatatctca gacagtccta ttgataagta
     2581 tggctttaaa gatatctatc aaaaagataa tcttacccta tatgaaaatc aatactctct
     2641 tccgattgca gttgctagtc aatctgttta caatgatgtc aagttcaatg aacatacctt
     2701 ggataatcag gcctcatttt taaatcaact tgctaacgtc aattttgatt atttttctcc
     2761 aataccttat gaaaaaacag aaaaaataga aaatactaat gatttgatta gtatcacaag
     2821 ttcttcaaat gaagatgcag caatccagta tcaaattgaa gttccagaaa acagccaagt
     2881 ttatctctct ttcataaacc ttcacttttc taacgataaa caaaagaagg ttgacatcct
     2941 tgtaaatggt gaaaaaaaga cttttacaac tgataatgtc ttctccttct ttaatctagg
     3001 atatactaaa gagaaaaaaa ctttcaatat caatgttagt ttccctggaa attcacaagt
     3061 atcatttgaa tctcctacct tctatcgttt agataccaaa actttcaccg aggcaattca
     3121 aaaaattaaa gaac
//
LOCUS       DBMVGT010000122         3067 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.122, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000122 DBMVGT010000000
VERSION     DBMVGT010000122.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3067)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.122"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..2082
                     /locus_tag="AC0DU4_002071"
     CDS             <1..2082
                     /locus_tag="AC0DU4_002071"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000907130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003899 - DNA-directed RNA polymerase
                     activity [Evidence IEA];
                     GO_function: GO:0032549 - ribonucleoside binding [Evidence
                     IEA];
                     GO_process: GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HIN4237973.1"
                     /translation="HYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFVQTPYRKV
                     DRETGVVTNEIVWLTADEEDEYTVAQANSRLNEDGTFAEKIVMGRHQGVNQEYPANIV
                     DYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLINPQAPYVGTGMEYQA
                     AHDSGAAVIAQYDGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKV
                     GDVVEKGDFIADGPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSV
                     HLEEYESETRDTKLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTP
                     KGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRVNGDELQSGVN
                     MLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPS
                     RMNIGQVMELHLGMAARTLGIHIATPVFDGASSEDLWSTVKEAGMDSDAKTILYDGRT
                     GEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSTVTQQPLGGKAQFGGQRFGEMEV
                     WALEAYGASNVLQEILTYKSDDINGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSL
                     GLDMRVLDEDDQEVELRDLDEGMDEDVIHVDDLEKAREKAAQEAKAAFEAEEAEKATK
                     AEATEEAAEQE"
     gene            2115..>3067
                     /locus_tag="AC0DU4_002072"
     CDS             2115..>3067
                     /locus_tag="AC0DU4_002072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HIN4237974.1"
                     /translation="MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPERE
                     GLFDEVIFGPTKDWECACGKYKRIRYRGIVCDRCGVEVTRTKVRRERMGHIELKAPVS
                     HIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEHKSIMTEREYRERLR
                     EYGYGSFVAKMGAEAIQDLLKQVDLEKEIAELKEELKTATGQKRVKAIRRLDVLDAFY
                     KSGNKPEWMILNILPVIPPDLRPMLQLDGGRFASSDLNDLYRRVINRNNRLARLLELN
                     APGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSL"
BASE COUNT          886 a          632 c          746 g          803 t
ORIGIN      
        1 cactacactc actatggtcg tatgtgtcca atcgagacac ctgaaggacc taacatcggt
       61 ttgatcaata acttgtcatc ttacggacac ttgaacaaat atggttttgt tcaaacacca
      121 taccgtaagg ttgaccgtga aacaggtgtt gtcacgaacg aaattgtttg gttgacagct
      181 gatgaagaag atgaatatac tgtagctcag gctaactctc gtctgaatga agatggaacc
      241 tttgctgaga agattgtcat gggacgtcac caaggggtca accaagagta tccagctaat
      301 attgttgact acatggacgt ttcaccaaaa caggtagttg ccgttgcgac agcatgtatt
      361 cctttcttgg aaaacgatga ctccaaccgt gccctcatgg gagccaatat gcaacgtcag
      421 gctgtgccat tgattaatcc tcaggcacct tacgttggta ctggtatgga ataccaagca
      481 gcccacgatt ctggtgcggc tgtgattgct cagtatgatg gtaaagttac ttacgcagat
      541 gctgacaagg tagaagttcg tcgtgaagat ggttcattgg atgtttacca catccaaaaa
      601 ttccgtcgtt caaactcagg tactgcttac aaccaacgca ctctcgtaaa agttggtgat
      661 gtcgttgaaa aaggcgattt catcgctgac ggaccttcta tggaaaatgg agaaatggcg
      721 cttggacaaa acccaatcgt tgcctacatg acttgggaag gttacaactt cgaggatgcc
      781 gttatcatga gcgaacgctt ggtgaaggac gatgtctaca catctgttca ccttgaagaa
      841 tacgaatcag aaacgcgcga tacaaagctt gggcctgaag aaatcactcg cgaaattcca
      901 aacgttggtg aagatgccct caaagacctt gacgaaatgg ggattatccg tattggtgct
      961 gaggttaaag aaggtgatat tcttgtaggt aaagtaacac ctaagggtga gaaagatctt
     1021 tcagctgaag aacgtctctt gcacgctatc tttggagaca agtctcgtga agtgcgtgat
     1081 acttctcttc gtgtaccaca cggtgccgat ggtgtcgttc gtgatgttaa gatctttaca
     1141 cgtgtaaatg gagatgagtt gcaatcaggt gttaacatgt tggttcgtgt ttacatcgct
     1201 caaaaacgta agattaaggt cggagataaa atggccggac gtcacggaaa caaaggggtt
     1261 gtctctcgta tcgttcctgt agaagacatg ccttaccttc cagacggaac tccagtcgac
     1321 atcatgttga acccacttgg ggtgccatca cgtatgaata tcggtcaggt tatggagctt
     1381 caccttggta tggcagctcg tactcttggt attcacattg cgacaccagt ctttgatgga
     1441 gcaagctctg aagatctttg gtcaactgtt aaagaagcag gtatggatag cgatgccaag
     1501 acaatccttt acgatggacg tacaggtgaa ccatttgata accgtgtttc tgttggagtc
     1561 atgtacatga ttaaactcca ccacatggtt gacgataaat tgcatgcgcg ttcagtcgga
     1621 ccttactcaa ctgttaccca acaaccactc ggaggtaaag ctcagtttgg tggacaacgt
     1681 ttcggtgaga tggaggtttg ggctcttgaa gcctacggtg cgtcaaatgt ccttcaagaa
     1741 atcttgactt acaagtcgga cgatatcaac ggacgtttga aagcctatga agctattaca
     1801 aaaggcaaac caattccaaa accaggtgtt ccagaatcct tccgagttct tgtcaaagaa
     1861 ttgcaatctc ttggtcttga catgcgtgtc ctagacgaag atgaccaaga agtggaactt
     1921 cgcgacttgg atgaaggaat ggacgaagat gtcatccacg tagatgacct tgaaaaagcc
     1981 cgcgaaaaag cagcccaaga ggctaaagca gcctttgaag ctgaagaagc tgagaaagca
     2041 acaaaagcgg aagcaacaga agaagctgct gaacaagaat aagcagttca cttagaatag
     2101 aaagggaaga aatagtggtt gatgtaaatc gttttaaaag tatgcaaatc accctagctt
     2161 ctccaagtaa agtccgttca tggtcttatg gagaagtcaa aaaacctgaa acaatcaatt
     2221 atcggacctt gaaaccagaa cgtgaaggac tctttgatga agtgatcttt ggtcctacaa
     2281 aagactggga atgtgcttgt ggtaagtaca aacgcattcg ttacagagga attgtttgtg
     2341 accgctgtgg ggttgaagta acgcgtacga aagttcgtcg tgagcgtatg ggacatatcg
     2401 aattgaaagc tcctgtatct cacatctggt acttcaaggg gattccaagc cgtatgggct
     2461 tgacccttga tatgagccct cgtgccctcg aggaagttat ctactttgcg gcttatgtgg
     2521 tgattgatcc taaggataca ccacttgagc acaagtctat catgacagag cgcgaatacc
     2581 gagagcgctt gcgtgaatat ggttatggtt catttgttgc caagatgggt gcggaagcca
     2641 tccaagacct tttgaagcaa gtagatcttg aaaaagaaat tgctgaactc aaagaagaat
     2701 tgaaaacagc tactggacaa aaacgtgtca aagccatccg tcgtttggat gttttggatg
     2761 ccttttacaa gtctggaaac aaacctgaat ggatgattct taacatcctt ccggttatcc
     2821 caccagatct tcgtccaatg ttgcagttgg atggtggccg ttttgcctca tctgacttga
     2881 atgaccttta ccgccgtgtt atcaaccgta acaaccgttt ggctcgtttg cttgagttaa
     2941 atgcaccagg tatcatcgtt caaaatgaga agcgtatgct tcaagaagca gttgacgctt
     3001 tgattgacaa tggtcgtcgt ggtcgtccaa tcacaggacc aggtagccgt ccattgaaat
     3061 cattgag
//
LOCUS       DBMVGT010000123         3058 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.123, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000123 DBMVGT010000000
VERSION     DBMVGT010000123.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3058)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3058)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3058
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.123"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..782)
                     /locus_tag="AC0DU4_002073"
     CDS             complement(<1..782)
                     /locus_tag="AC0DU4_002073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4237975.1"
                     /translation="MLTVSDVSLRFSDRKLFDDVNIKFTEGNTYGLIGANGAGKSTFL
                     KILAGDIEPTTGHISLGPDERLSVLRQNHFDYEDERAIDVVIMGNEKLYSIMKEKDAI
                     YMKEDFSDEDGVRAAELEGEFAELGGWEAESEASQLLQNLNIPEELHYQNMSELANGE
                     KVKVLLAKALFGKPDVLLLDEPTNGLDIQSITWLEDFLIDFDNTVIVVSHDRHFLNKV
                     CTHMADLDFGKIKLYVGNYDFWKESSELAAKLLADRNAKAEE"
     gene            988..2013
                     /gene="trpS"
                     /locus_tag="AC0DU4_002074"
     CDS             988..2013
                     /gene="trpS"
                     /locus_tag="AC0DU4_002074"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004830 - tryptophan-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006436 - tryptophanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HIN4237976.1"
                     /translation="MTKPIILTGDRPTGKLHIGHYVGSLKNRVLLQEEDKYDMFVFLA
                     DQQALTDHAKDPQTIVESIGNVALDYLAVGLDPNKSTIFIQSQIPELAELSMYYMNLV
                     SLARLERNPTVKTEISQKGFGESIPTGFLVYPIAQAADITAFKANYVPVGTDQKPMIE
                     QTREIVRSFNNAYNCDVLVEPEGIYPENERAGRLPGLDGNAKMSKSLNNGIYLADDAD
                     TLRKKVMSMYTDPDHIRVEDPGKIEGNMVFHYLDVFGRPEDAQEIADMKERYQRGGLG
                     DVKTKRYLLEILERELGPIRERRIEFAKDMGEVYNMIQKGSERAREVAGQTLSEVKGA
                     MGLHYFN"
     gene            2165..>3058
                     /gene="guaB"
                     /locus_tag="AC0DU4_002075"
     CDS             2165..>3058
                     /gene="guaB"
                     /locus_tag="AC0DU4_002075"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003085743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0003938 - IMP dehydrogenase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006177 - GMP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HIN4237977.1"
                     /translation="MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTL
                     NIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPF
                     FLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMT
                     SENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKD
                     EFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDR
                     TLIAGNIATAEGARALYEAGVD"
BASE COUNT          935 a          516 c          645 g          962 t
ORIGIN      
        1 ttttcttctg ctttagcatt acggtctgct agcaatttag cagcaagctc agaagattcc
       61 ttccagaagt cgtagtttcc gacatagagt ttgatttttc caaagtcaag gtcggccatg
      121 tgagtacaaa ctttgtttaa gaagtgacgg tcgtgggata ctacgataac tgtgttatca
      181 aagtcaatca agaagtcttc taaccaagta atcgattgga tatccaaacc gttagtaggc
      241 tcgtccaaga gaagaacatc tggtttacca aaaagtgctt tggcgaggag aacctttact
      301 ttttcaccgt tggccaattc gctcatgttt tggtagtgta attcttctgg aatgtttagg
      361 ttttgaagta gttgagaggc ttcactctct gcttcccaac ctccaagttc ggcaaactct
      421 ccttcgagtt cggcagcacg aaccccgtcc tcgtctgaga aatcttcctt catgtagata
      481 gcatctttct ctttcatgat gctataaagt ttttcatttc ccatgataac gacatcaatg
      541 gcacgttcat cttcgtagtc aaagtgattt tgacgaagaa cagagagacg ttcatctgga
      601 ccaagagaga tgtgaccagt agtaggttcg atatctccag ctaaaatttt taaaaaggtt
      661 gattttccgg caccattagc accgattaat ccgtaagtat ttccttctgt aaatttgata
      721 ttgacatcat caaaaagttt gcgatcacta aaacgtagtg aaacatcaga tactgtaagc
      781 aatatttttc tcctatatgt gtaatatatt tattctacta gaaaatacag aaatattcaa
      841 atttttattt gtcaattttg tgtaaattat atttacagta tcctttacac aaatctgtaa
      901 aaagcaaggc tgatttattt tgataaatta cggttatttc attaaaaaaa tgctataatt
      961 gaaaggacta tatcgaagga gaacaaaatg actaaaccca ttattttaac aggagaccgt
     1021 ccaacaggaa aattgcatat tggacattat gttggaagtc tcaaaaatcg agtattatta
     1081 caggaagagg ataagtatga tatgtttgtg ttcttggctg accaacaagc cttgacagat
     1141 catgccaaag atcctcaaac cattgtagag tctatcggaa atgtggcttt ggattatctt
     1201 gcagttggat tggatccaaa taagtcaact atttttattc aaagccagat tccagagttg
     1261 gctgagttgt ctatgtatta tatgaatcta gtttcgttag cacgtttgga gcgaaatcca
     1321 acagtcaaga cagagatttc tcagaaagga tttggagaaa gcattccgac aggattcttg
     1381 gtctatccaa tcgctcaagc agctgatatc acagctttca aggctaatta tgttcctgtt
     1441 gggacagatc agaaaccaat gattgagcaa actcgtgaaa ttgttcgttc ttttaacaat
     1501 gcatataact gtgatgtctt ggtagagccg gaaggtattt atccagaaaa tgagagagca
     1561 gggcgtttgc ctggtttaga tggaaatgct aaaatgtcta aatcactaaa taatggtatt
     1621 tatttagctg atgatgcgga tactttgcgt aaaaaagtaa tgagtatgta tacagatcca
     1681 gatcatatcc gcgttgagga tccaggtaag attgagggaa atatggtttt ccattatcta
     1741 gatgtttttg gtcgtccaga agatgctcaa gaaattgctg atatgaaaga acgttatcaa
     1801 cgaggtggtc ttggtgatgt gaagaccaag cgttatctac ttgaaatatt agaacgtgaa
     1861 ctgggtccta ttcgtgagcg ccgtattgaa tttgctaagg atatgggaga agtttataat
     1921 atgattcaaa aaggtagtga aagagcgcgt gaagttgcgg gtcaaaccct atctgaggta
     1981 aaaggggcaa tgggacttca ttactttaat taagtttatt ttacaagaaa ctatcatttc
     2041 tatctcgaag aaaagatagt tttttattta cccctgtaac atttgacaaa tttttataga
     2101 atggtatgat agatacaata taaaaagagt caagctcaaa aagaaagaaa agaggaaact
     2161 tcgaatgtct aattgggaca ctaaattttt gaaaaaaggt tttacctttg atgatgtatt
     2221 gcttattcca gctgaaagtc atgtgttgcc taacgatgca gatttaacaa ctaaattggc
     2281 agataatttg actttaaata tcccaattat taccgctgcc atggacacag ttacagagag
     2341 tcaaatggcc attgctattg ctcgtgcagg tggtctcgga gttatccata aaaacatgtc
     2401 aattgctcaa caagcagacg aggttcgtaa ggtaaaacgt tctgaaaatg gagttattat
     2461 tgatccgttc ttcttgacgc ctgaacatac aattgctgaa gcagatgagc ttatgggtcg
     2521 ttaccgcatc agtggtgttc cagttgttga aacacttgaa aatcgtaaat tggttggtat
     2581 tttgacaaac cgagatcttc gttttatttc agattataat caaccaattt caaaccatat
     2641 gactagtgaa aatcttgtta ctgctcctgt gggtacggat cttgcaacgg ctgagagtat
     2701 tcttcaagag catcgtattg aaaaacttcc gttggtcgat gaagaaggca gtctttctgg
     2761 tttgatcact atcaaagata ttgaaaaagt tattgagttt ccaaatgcgg ctaaagatga
     2821 atttggtcgt cttctagttg caggtgcagt aggtgttact tcagatacat ttgaacgtgc
     2881 agaggctctt tttgaggcag gagcggatgc gattgttatt gatactgcac atggtcattc
     2941 tgcaggtgtc ttgcgtaaaa ttgccgagat tcgtgctcat ttcccagatc ggactttgat
     3001 tgctggaaat attgctactg ctgaaggtgc acgtgccctt tatgaagcgg gtgtagac
//
LOCUS       DBMVGT010000124         3016 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.124, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000124 DBMVGT010000000
VERSION     DBMVGT010000124.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3016)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3016)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3016
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.124"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..2993
                     /gene="mfd"
                     /locus_tag="AC0DU4_002076"
     CDS             <1..2993
                     /gene="mfd"
                     /locus_tag="AC0DU4_002076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000258090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003684 - damaged DNA binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HIN4237978.1"
                     /translation="SLRGDILDIFEISQLEPCRIEFFGDEIDGIRSFEVETQLSKENK
                     TELTIFPASDMLLREKDYQRGQSALEKQISKTLSPILKSYLEEILSSFHQKQSHADSR
                     KFLSLCYDKTWTVFDYIEKDTPIFFDDYQKLMNQYEVFERDLAQYFTEELQNSKAFSD
                     MQYFSDIEQIYKKQSPVTFFSNLQKGLGNLKFDKIYQFNQYPMQEFFNQFSFLKEEIE
                     RYKKMDYTIILQSSNSMGSKTLEDMLEEYQIKLDSRDKTNICKESVNLIEGNLRHGFH
                     FVDEKILLITEHEIFQKKLKRRFRRQHVSNAERLKDYNELEKGDYVVHHIHGIGQYLG
                     IETIEIKGIHRDYVSVQYQNGDQISIPVEQIHLLSKYISSDGKAPKLNKLNDGHFKKA
                     KQKVKNQVEDIADDLIKLYSERSQLKGFAFSADDDDQDAFDDAFPYVETDDQLRSIEE
                     IKRDMQASQPMDRLLVGDVGFGKTEVAMRAAFKAVNDHKQVVILVPTTVLAQQHYTNF
                     KERFQNFAVNVDVLSRFRSKKEQTATLEKLKNGQVDILIGTHRVLSKDVVFADLGLMI
                     IDEEQRFGVKHKETLKELKKQVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYP
                     VQTYVLEKNDSVIRDAVLREMERGGQVYYLYNKVDTIVQKVSELQELIPEASIGYVHG
                     RMSEVQLENTLLDFIEGQYDILVTTTIIETGVDIPNANTLFIENADHMGLSTLYQLRG
                     RVGRSNRIAYAYLMYRPEKSISEVSEKRLEAIKGFTELGSGFKIAMRDLSIRGAGNLL
                     GKSQSGFIDSVGFELYSQLLEEAIAKRNGNANANTRTKGNAELILQIDAYLPDTYISD
                     QRHKIEIYKKIRQIDNRVNYEELQEELIDRFGEYPDVVAYLLEIGLVKSYLDKVFVQR
                     VERKDNKITIQFEKVTQRLFLAQDYFKALSVTNLKAGIAENKGLMELVFDVQNKKDYE
                     ILEGLLIFGESLLEIKEFKEENSI"
BASE COUNT         1020 a          441 c          611 g          944 t
ORIGIN      
        1 ttagtcttcg aggagatatt ttagatattt ttgaaatatc ccagttagaa ccttgtcgaa
       61 ttgagttttt tggtgatgaa attgatggta tcaggtcatt tgaagtagaa acacaattat
      121 cgaaagaaaa taagacagaa ctcactatct ttccagctag tgatatgctt ttgagagaaa
      181 aggattatca acgaggacag tcagctttag aaaaacaaat ttcaaaaact ttatcaccta
      241 ttttgaaatc atacctagaa gaaattcttt caagttttca ccaaaaacaa agtcatgcag
      301 actctcggaa gtttttatct ttgtgctatg ataagacatg gactgtcttt gattatattg
      361 aaaaagatac tccaatattc tttgatgatt atcaaaaatt gatgaatcag tatgaagtct
      421 ttgaaagaga cttagcgcag tactttacag aagaattaca gaatagtaaa gcattttctg
      481 atatgcagta tttttctgat attgaacaaa tctataaaaa acaaagtcca gtgacctttt
      541 tctctaatct tcaaaagggt ttaggaaatc tcaaatttga caaaatttat caattcaatc
      601 aatatcctat gcaggaattt ttcaatcagt tttcttttct aaaagaagaa attgaacgat
      661 ataaaaaaat ggattacacc attattctgc agtctagcaa ttcaatggga agtaaaacat
      721 tggaggatat gttagaggaa tatcagatta aattggattc tagagataag acaaatatct
      781 gtaaagaatc tgtaaactta atagagggta atctcagaca tggttttcat tttgtagatg
      841 aaaagatttt attgataact gaacatgaga tttttcaaaa gaaattaaag cgtcgttttc
      901 gaagacaaca tgtttcaaat gcagagagat taaaagatta caatgaactt gaaaaagggg
      961 actatgttgt ccatcatatc catgggattg gtcaatatct aggaattgaa accattgaaa
     1021 tcaagggaat tcatcgcgat tatgtcagtg tccaatacca aaatggtgat caaatttcta
     1081 tccccgtgga acagattcat ctactgtcca aatatatttc aagtgatggt aaagctccaa
     1141 aactcaataa attaaatgac ggtcatttta aaaaggccaa gcaaaaggtt aagaaccagg
     1201 tagaggatat agctgatgat ttaatcaaac tctactctga acgtagtcag ttgaagggtt
     1261 ttgctttctc agctgatgat gatgatcaag atgcctttga tgatgctttc ccttatgttg
     1321 aaacggatga tcaacttcgt agtattgagg aaatcaaaag ggatatgcag gcttctcagc
     1381 caatggatcg acttttagtt ggggatgttg gttttggaaa gactgaagtt gctatgcgtg
     1441 cagcctttaa agcagtcaat gatcacaaac aggttgtcat tctagttccg acgacggttt
     1501 tagcgcaaca gcactatacg aattttaagg aacgattcca aaattttgca gttaatgttg
     1561 atgtgttgag tcgctttaga agtaaaaaag agcagactgc aacacttgaa aaattgaaaa
     1621 acggtcaagt cgatattttg attggaacac atcgtgtttt gtcaaaagat gttgtgtttg
     1681 ctgatttggg cttgatgatt attgatgagg aacagcgatt tggtgtcaag cataaggaaa
     1741 ctttgaaaga actgaagaaa caagtggatg tcctaacctt gaccgctacg ccaatccctc
     1801 gtaccctcca tatgtctatg ctgggaatca gagatttgtc tgttattgaa actccgccga
     1861 ctaatcgcta tcctgttcag acctatgttt tggaaaagaa tgatagtgtc attcgtgatg
     1921 ctgtcttgcg tgaaatggag cgtggaggtc aagtttacta tctttacaac aaagttgaca
     1981 caattgttca gaaggtttca gaattacagg agttgattcc ggaggcttcg attggatatg
     2041 ttcatggtcg aatgagtgaa gtccagttgg aaaatactct attagacttt attgagggac
     2101 aatacgatat cttggtgacg actactatta ttgagacagg ggtggacatt ccaaatgcta
     2161 atactttatt tattgaaaat gcggaccata tgggcttgtc aaccttatat cagttaagag
     2221 gaagagtcgg tcgtagtaat cgtattgctt atgcttatct catgtatcgt ccagaaaaat
     2281 caatcagtga agtctctgaa aagagattag aagcgattaa aggatttaca gaattgggct
     2341 ctggctttaa gattgcaatg cgagatcttt cgattcgtgg agcaggaaat cttttaggaa
     2401 aatcccagtc tggtttcatt gattctgttg gttttgaatt gtattcgcag ttattagagg
     2461 aagctattgc taaacgaaac ggtaatgcta acgctaacac aagaaccaaa gggaatgctg
     2521 agttgatttt gcaaattgat gcctatcttc ctgatactta tatttctgat caacgacata
     2581 agattgaaat ttacaagaaa attcgtcaaa ttgacaaccg tgtcaattat gaagagttac
     2641 aagaggagtt gatagaccgt tttggagaat acccagatgt agtagcctat cttttagaga
     2701 ttggtttggt caaatcatac ttggacaagg tctttgttca acgtgtggaa agaaaagata
     2761 ataaaattac aattcaattt gaaaaagtca ctcaacgact gtttttagct caagattatt
     2821 ttaaagcttt atccgtaacg aacttaaaag caggcatcgc tgagaataag ggattaatgg
     2881 agcttgtatt tgatgtccaa aataagaaag attatgaaat tttagaaggt ctgctgattt
     2941 ttggagaaag tttattagag ataaaagagt ttaaggaaga aaattccatt tgatattttt
     3001 cttctataaa atagat
//
LOCUS       DBMVGT010000125         3001 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.125, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000125 DBMVGT010000000
VERSION     DBMVGT010000125.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3001)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.125"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..429
                     /locus_tag="AC0DU4_002077"
     CDS             <1..429
                     /locus_tag="AC0DU4_002077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HIN4237979.1"
                     /translation="NISFYTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSMERARL
                     LSSATQNGTVKLEIKDGVVSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYLIDSL
                     KALNSEKVTISFISAVRPFTLVPADTDEDFMQLITPVRTN"
     gene            494..688
                     /locus_tag="AC0DU4_002078"
     CDS             494..688
                     /locus_tag="AC0DU4_002078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 domain-containing protein"
                     /protein_id="HIN4237980.1"
                     /translation="MYQVGNFVEMKKSHACTIKSTGKKANRWEITRVGADIKIKCSNC
                     EHVVMMGRYDFERKMNKIID"
     gene            772..1887
                     /gene="ychF"
                     /locus_tag="AC0DU4_002079"
     CDS             772..1887
                     /gene="ychF"
                     /locus_tag="AC0DU4_002079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HIN4237981.1"
                     /translation="MALTAGIVGLPNVGKSTLFNAITKAGAEAANYPFATIDPNVGMV
                     EVPDERLQKLTEMITPKKTVPTTFEFTDIAGIVKGASKGEGLGNKFLANIREVDAIVH
                     VVRAFDDENVMREQGREDAFVDPLADIDTINLELILADLESVNKRYARVEKMARTQKD
                     KESVAEFNVLQKIKPVLEDGKSARTIEFTDEEQKVVKGLFLLTTKPVLYVANVDEDVV
                     SEPDSIDYVKQIREFAATENAEVVVISARAEEEISELDDEDKKEFLEAIGLIESGVDK
                     LTRAAYHLLGLGTYFTAGEKEVRAWTFKRGMKAPQAAGIIHSDFEKGFIRAVTMSYED
                     LVKYESEKAVKEAGRLREEGKEYIVQDGDIMEFRFNV"
     gene            1958..2527
                     /gene="pth"
                     /locus_tag="AC0DU4_002080"
     CDS             1958..2527
                     /gene="pth"
                     /locus_tag="AC0DU4_002080"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004045 - peptidyl-tRNA hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HIN4237982.1"
                     /translation="MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIF
                     KADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKI
                     RLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
                     LQSVDKVDDSVNYYLQEKNFEKTMQRYNG"
     gene            2528..>3001
                     /locus_tag="AC0DU4_002081"
     CDS             2528..>3001
                     /locus_tag="AC0DU4_002081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000258090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4237983.1"
                     /translation="MVTLLDLFSENDQIKKWHQNLTDKKRQLILGLSTSTKALAIASS
                     LEKEDRIVLLTSTYGEAEGLVSDLISILGEELVYPFLVDDAPMVEFLMSSQEKIISRV
                     EALRFLTDSSKKGILVCNIAASRLILPSPNAFKDSIVKISVGEEYDQHAFIHQLKE"
BASE COUNT         1002 a          465 c          647 g          887 t
ORIGIN      
        1 aatattagct tctatactcg tctcctagaa ggaaactatc ctgatacaga tcgcttgatt
       61 ccaacagact ttaacactac tattactttt aatgtggtaa acttacgcca gtcaatggag
      121 cgtgcccgtc ttttatcaag tgcgactcaa aatggtactg tgaaacttga aattaaggat
      181 ggggttgtta gcgcccatgt tcactctcca gaagttggta aagtaaacga agaaatcgat
      241 actgatcagg ttactggtga agatttgacc attagtttca acccaactta cttgattgat
      301 tctcttaaag ctttaaatag cgaaaaggtg actattagct ttatctcagc tgttcgtcca
      361 tttactcttg tgccagcaga tactgacgaa gacttcatgc agctcattac accagttcgt
      421 acaaattaag tgaaagaggt tgagcctggc tcgcctcttt tatgatataa tcgaaaaaga
      481 aaaggagagt agtatgtatc aagttggaaa ttttgttgag atgaaaaaat cacacgcttg
      541 tacaatcaag tcgactggta aaaaggctaa tcgttgggaa attacacgtg taggagcaga
      601 tatcaaaata aaatgcagta attgtgagca tgttgtcatg atggggcgat atgattttga
      661 gcgaaaaatg aataaaatta ttgactgaga acccttagtt agagggttag cactttatcc
      721 ctttttgtgt tataatatta gggattgaaa tgaaaacgga gaatgagaaa tatggctttg
      781 acagcaggta tcgttggttt gccaaacgtt ggtaaatcaa cactatttaa tgcaattaca
      841 aaagcaggag cagaggcagc aaactaccca tttgcgacta ttgatccaaa tgttggaatg
      901 gtggaagttc cagatgaacg cctacaaaaa ctaactgaaa tgataactcc taaaaagaca
      961 gttcccacaa catttgaatt tacggatatt gcagggattg taaaaggagc ttcaaaagga
     1021 gaagggctag ggaataaatt cttggccaat attcgtgaag tagatgcgat tgttcacgta
     1081 gttcgtgctt ttgatgatga aaatgtgatg cgcgagcaag gacgtgaaga cgcctttgtg
     1141 gatccacttg cagatattga caccattaac ctagaattga ttcttgcaga cttagaatca
     1201 gtcaataaac gatatgcgcg tgtagaaaag atggcacgta cgcaaaaaga taaagaatca
     1261 gtagcagaat tcaatgttct tcaaaagatt aaaccagtcc tagaagacgg gaaatcagct
     1321 cgtaccattg aatttacaga tgaggaacaa aaggttgtca aaggtctttt ccttttgacg
     1381 actaaaccag ttctttatgt agctaatgtg gacgaggatg tggtttcaga acctgactct
     1441 atcgactatg tcaaacaaat tcgtgaattt gcagcgacag aaaatgctga agtagtcgtt
     1501 atttctgcgc gtgctgagga agaaatttct gaattggatg atgaagataa aaaagagttt
     1561 cttgaagcca ttggtttgat agaatcaggt gtagataagt tgacgcgtgc agcttaccac
     1621 ttgcttggat tgggaactta cttcacagct ggtgaaaaag aagttcgcgc ttggactttc
     1681 aaacgtggta tgaaggctcc tcaagcagct ggtattatcc actcagactt tgaaaaaggc
     1741 tttattcgtg cagtaaccat gtcatatgag gatctagtga aatacgaatc tgaaaaggcc
     1801 gtaaaagaag ctggacgctt gcgtgaagaa ggaaaagaat atatcgttca agatggcgat
     1861 atcatggaat tccgctttaa tgtctaaaaa ttaataaatg gtgtcaatta ggttggaaaa
     1921 aaattccaac ccttttggct tttgaaagga aaaataaatg accaaattac ttgtaggctt
     1981 gggaaatcca ggggataaat attttgaaac aaaacacaat gttggtttta tgttgattga
     2041 tcaactagcg aagaaacaga atgtcacttt tacacacgat aagatattta aagctgacct
     2101 agcatccttt ttcctaaatg gagaaaaaat ttatctggtt aaaccaacga cctttatgaa
     2161 tgaaagtgga aaagcagttc atgctttatt aacttactat ggtttggata ttgacgattt
     2221 acttatcatt tacgatgatc ttgacatgga agttgggaaa attcgtttaa gagcaaaagg
     2281 ctcagcaggt ggtcataatg gtatcaagtc tattattcaa catataggaa ctcaggtctt
     2341 taaccgtgtt aagattggaa ttggaagacc taaaaatggt atgtcagttg ttcatcatgt
     2401 tttgagtaag tttgacaggg atgattatat cggtatttta cagtctgttg acaaagttga
     2461 cgattctgta aactactatt tacaagagaa aaattttgag aaaacaatgc agaggtataa
     2521 cggataaatg gtgaccttat tagatttatt ctcagaaaat gatcagatta aaaaatggca
     2581 tcaaaattta actgataaga aaagacaact aatacttggt ttatcaacat ctactaaggc
     2641 tcttgcaatt gcaagcagtt tagaaaaaga agataggatt gtgttattga cgtcaactta
     2701 tggagaagca gaaggacttg ttagtgatct tatatctatc ttgggtgagg aactcgtcta
     2761 tccatttttg gtagatgatg ctcctatggt ggagtttttg atgtcttcac aggaaaaaat
     2821 tatttcacgg gttgaagcct tgcgtttttt gactgattca tctaagaaag ggattttagt
     2881 ttgtaatatc gcagcaagtc gattgatttt accgtctccc aatgcattca aagatagtat
     2941 tgtaaaaatc tcagttggtg aagaatatga tcaacacgcg tttatccatc agttaaagga
     3001 a
//
LOCUS       DBMVGT010000126         2994 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.126, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000126 DBMVGT010000000
VERSION     DBMVGT010000126.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2994)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2994)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2994
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.126"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            49..1317
                     /locus_tag="AC0DU4_002082"
     CDS             49..1317
                     /locus_tag="AC0DU4_002082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydrolase"
                     /protein_id="HIN4237984.1"
                     /translation="MRKFLIILLLPSFLTISKVVSTEKEVVYTSKEIYYLSQSDFGIY
                     FREKLSSPMVYGEVPVYANEDLVVESGKLTPKTSFQITEWRLNKQGIPVFKLSNHQFI
                     AADKRFLYDQSEVTPTIKKAWLESDFKLYNSPYDLKEVKSSLSAYSQVSIDKTMFVEG
                     REFLHIDQAGWVAKESTSEEDNRMSKVQEMLSEKYQKDSFSIYVKQLTTGKEAGINQD
                     EKMYAASVLKLSYLYYTQEKINEGLYQLDTTVKYVSAVNDFPGSYKPEGSGSLPKKED
                     NKEYSLKDLITKVSKESDNVAHNLLGYYISNQSDATFKSKMSAIMGDDWDPKEKLISS
                     KMAGKFMEAIYNQNGFVLESLTKTDFDSQRIAKGVSVKVAHKIGDADEFKHDTGVVYA
                     DSPFILSIFTKNSDYDTISKIAKDVYEVLK"
     gene            1314..2591
                     /gene="tilS"
                     /locus_tag="AC0DU4_002083"
     CDS             1314..2591
                     /gene="tilS"
                     /locus_tag="AC0DU4_002083"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016879 - ligase activity, forming
                     carbon-nitrogen bonds [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HIN4237985.1"
                     /translation="MREPDFLNHFLKKGYFKKHAKAVLALSGGLDSMFLFKVLSTYQK
                     ELEIELILAHVNHKQRIESDWEEKELRKLAAEAELPIYISNFSGEFSEARARNFRYDF
                     FQEVMKKTGATALVTAHHADDQVETILMRLIRGTRLRYLSGIKEKQVVGEIEIIRPFL
                     HFQKKDFPSIFHFEDTSNQENHYFRNRIRNSYLPKLEKENPRFRDAILGIGNEILDYD
                     LAIAELSNNINVEDLQQLFSYSESTQRVLLQTYLNRFPDLNLTKTQFAEVQQILKSKS
                     QYRHPIKNGYELIKEYQQFQICKISPQADEKEDELVLHYQNQVAYQGYLFSFGLPLEG
                     ELIQQIPVSRETSIHIRHRKTGDVLIQNGHRKKLRRLFIDLKIPMEKRNSALIIEQFG
                     EIVSILGIATNNLSKKTKNDIMNTVLYIEKIDR"
     gene            2595..>2994
                     /locus_tag="AC0DU4_002084"
     CDS             2595..>2994
                     /locus_tag="AC0DU4_002084"
                     /EC_number="2.4.2.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0016763 - pentosyltransferase activity
                     [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0043174 - nucleoside salvage [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosyltransferase"
                     /protein_id="HIN4237986.1"
                     /translation="MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKG
                     SIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDII
                     DTGQTLKNLRDMFKEREAASVKIATLLDKPE"
BASE COUNT         1067 a          433 c          564 g          930 t
ORIGIN      
        1 ctgataaaaa tcaattattg cgtttacaag aagaaaagga aaggaagaat gcgtaaattc
       61 ttaattattt tgttgctacc aagttttttg accatttcaa aagtcgttag cacagaaaaa
      121 gaagtcgtct atacttcgaa agaaatttat tacctttcac aatctgactt tggtatttat
      181 tttagagaaa aattaagttc tcccatggtt tatggagagg ttcctgttta tgcgaatgaa
      241 gatttagtag tggaatctgg gaaattgact cccaaaacaa gttttcaaat aaccgagtgg
      301 cgcttaaata aacaaggaat tccagtattt aagctatcaa atcatcaatt tatagctgcg
      361 gacaaacgat ttttatatga tcaatcagag gtaactccaa caataaaaaa agcatggtta
      421 gaatctgact ttaaactgta caatagtcct tatgatttaa aagaagtgaa atcatcctta
      481 tcagcttatt cgcaagtatc aatcgacaag accatgtttg tagaaggaag agaatttcta
      541 catattgatc aggctggatg ggtagctaaa gaatcaactt ctgaagaaga taatcggatg
      601 agtaaagttc aagaaatgtt atctgaaaaa tatcagaaag attctttctc tatttatgtt
      661 aagcaactga ctactggaaa agaagctggt atcaatcaag atgaaaagat gtatgcagcc
      721 agcgttttga aactctccta tctctattat acgcaagaaa aaataaatga gggtctttat
      781 cagttagata cgactgtaaa atacgtatct gcagtcaatg attttccagg ttcttataaa
      841 ccagagggaa gtggtagtct tcctaaaaaa gaagataata aagaatattc tttaaaggat
      901 ttaattacga aagtatcaaa agaatctgat aatgtagctc ataatctatt gggatattac
      961 atttcaaacc aatctgatgc cacattcaaa tccaagatgt ctgccattat gggagatgat
     1021 tgggatccaa aagaaaaatt gatttcttct aagatggccg ggaagtttat ggaagctatt
     1081 tataatcaaa atggatttgt gctagagtct ttgactaaaa cagattttga tagtcagcga
     1141 attgccaaag gtgtttctgt taaagtagct cataaaattg gagatgcgga tgaatttaag
     1201 catgatacgg gtgttgtcta tgcagattct ccatttattc tttctatttt cactaagaat
     1261 tctgattatg atacgatttc taagatagcc aaggatgttt atgaggttct aaaatgaggg
     1321 aaccagattt tttaaatcat tttctcaaga agggatattt caaaaagcat gctaaggcgg
     1381 ttctagctct ttctggtgga ttagattcta tgtttctatt taaggtattg tctacttatc
     1441 aaaaagagtt agagattgaa ttgattctgg ctcatgtgaa tcataagcag agaattgaat
     1501 cagattggga agaaaaggaa ttaaggaagt tggctgctga agcagagctt cctatttata
     1561 tcagcaattt ttcaggagaa ttttcagaag cgcgtgcacg aaattttcgt tatgattttt
     1621 ttcaagaggt catgaaaaag acaggtgcga cagctttagt cactgcccac catgctgatg
     1681 atcaggtgga aacgattttg atgcgcttga ttcgaggaac tcgcttgcgc tatctatcag
     1741 gaattaagga gaagcaagta gtcggagaga tagaaatcat tcgtcccttc ttgcattttc
     1801 agaaaaaaga ctttccatca atttttcact ttgaagatac atcaaatcag gagaatcatt
     1861 attttcgaaa tcgtattcga aattcttact taccaaaatt ggaaaaagaa aatcctcgat
     1921 ttagggatgc aatcttaggc attggcaatg aaattttaga ttatgatttg gcaatagctg
     1981 aattatctaa caatattaat gtggaagatt tacagcagtt attttcttac tctgagtcta
     2041 cacaaagagt tttacttcaa acttatctga atcgttttcc agatttgaat cttacaaaaa
     2101 ctcagtttgc tgaagttcag cagattttaa aatctaaaag ccagtatcgt catccgatta
     2161 aaaatggcta tgaattgata aaagagtacc aacagtttca gatttgtaaa atcagtccgc
     2221 aggctgatga aaaggaagat gaacttgtgt tacactatca aaatcaggta gcttatcaag
     2281 gatatttatt ttcctttgga cttccattag aaggtgaatt aattcaacaa atacctgttt
     2341 cacgtgaaac atccatacac attcgtcatc gaaaaacagg agatgttttg attcaaaatg
     2401 ggcatagaaa aaaactcaga cgtttattta ttgatttgaa aatccctatg gaaaagagaa
     2461 actctgctct tattattgag caatttggtg aaattgtctc aattttggga attgcgacca
     2521 ataatttgag taaaaaaacg aaaaatgata taatgaacac tgtactttat atagaaaaaa
     2581 tagataggta aaaaatgtta gaaaacgata ttaaaaaagt cctcgtttca cacgatgaaa
     2641 ttacagaagc agctaaaaaa ctaggtgctc aattaactaa agactatgca ggaaaaaatc
     2701 caatcttagt tgggatttta aaaggatcta ttccttttat ggctgaattg gtcaaacata
     2761 ttgatacaca tattgaaatg gacttcatga tggtttctag ctaccatggt ggaacagcaa
     2821 gtagtggtgt tatcaatatt aaacaagatg tgactcaaga tatcaaagga agacatgttc
     2881 tatttgtaga agatatcatt gatacaggtc aaactttgaa gaatttgcga gatatgttta
     2941 aagaaagaga agcagcttct gttaaaattg caaccttgtt ggataaacca gaag
//
LOCUS       DBMVGT010000127         2993 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.127, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000127 DBMVGT010000000
VERSION     DBMVGT010000127.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2993)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.127"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1861
                     /locus_tag="AC0DU4_002085"
     CDS             <1..1861
                     /locus_tag="AC0DU4_002085"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurQ"
                     /protein_id="HIN4237987.1"
                     /translation="KLPEERQTSAETLESDTLTVLSDLNHASQKGLQTIFDCSVGRST
                     VNHPLGGRYQLTPTEASVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAYAVIEA
                     TARLVAAGANWSKARFSYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKD
                     SMSGTFEELTVPPTLVAFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLIK
                     KNFTQFEAIQADHKVTSASAVKYGGVVESLALATFGNYIGAEVTLPELKTALTAQLGG
                     FVFTSPEEIAGVEKVGQTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKEL
                     EEVPAVASDVVIKAKEKVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNE
                     EAIVKSVETMVDNIDKTNILFFAGGFSAADEPDGSAKFIVNILLNEKVCVAIDSFIAR
                     GGLIIGICNGFQALVKSGLLPYGNFEAANSTSPTLFYNDANQHVAKMVETRIANTNSP
                     WLAGVQVGDIHAIPVSHGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPN
                     GSVHAIEGITSKNGQIIGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK"
     gene            1954..>2993
                     /gene="purF"
                     /locus_tag="AC0DU4_002086"
     CDS             1954..>2993
                     /gene="purF"
                     /locus_tag="AC0DU4_002086"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004044 - amidophosphoribosyltransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HIN4237988.1"
                     /translation="MTYEVKSLNEECGVFGIWGHPDAAKLTYFGLHSLQHRGQEGAGI
                     LSNDQGQLKRHRDMGLLSEVFRNPANLDKLTGAGAIGHVRYATAGEASVDNIQPFLFR
                     FHDMQFGLAHNGNLTNAASLKKELEQRGAIFSATSDSEILAHLIRRSHNPSLMGKIKE
                     ALSLVKGGFAYILLFEDKLIAALDPNGFRPLSIGKMANGAVVVSSETCAFEVIGAEWI
                     RDLKPGEIVIIDDEGIQYDSYTDDTQLAICSMEYIYFARPDSNIHGVNVHTARKRMGA
                     QLAREFKHEADIVVGVPNSSLSAAMGFAEESGLPNEMGLIKNQYTQRTFIQPTQELRE
                     QGVRMKLSAVSGV"
BASE COUNT          827 a          637 c          711 g          818 t
ORIGIN      
        1 caaactccca gaagagcgtc aaacatctgc tgaaacactg gaatcagata cccttacggt
       61 tctatctgac ctcaaccatg caagtcaaaa aggattacag actatctttg actgctctgt
      121 tggacgctca acggttaatc acccacttgg tggtcgttac caactcacac caactgaggc
      181 atctgtgcag aaattgccag ttcaacacgg tgtgactcat actgcgtcgg tcattgctca
      241 aggtttcaac ccatatgtag ctgaatggtc tccataccac ggtgctgctt atgcggttat
      301 cgaagcaact gctcgtttgg tggctgctgg tgccaactgg tccaaggctc gtttctctta
      361 ccaagagtat ttcgagcgta tggataaaca agcagagcgt ttcggtcagc cagtagctgc
      421 tcttctaggt tctattgaag cacaaattca gcttggcttg ccatctatcg gtggtaagga
      481 ctccatgtct ggtacctttg aagaattgac cgttccgcca accttggttg cctttggggt
      541 gacgacggca gatagccgta aggtgctctc tccagaattt aaagctgttg gggaaaatat
      601 ctactacatc ccaggtcaag ccctctctgc agagattgat tttgacttga ttaagaaaaa
      661 ttttactcag tttgaagcca tccaagctga ccataaagtg acatctgcat cagctgtcaa
      721 atacggtggt gtagttgaaa gtttggctct tgctaccttt ggaaactata ttggtgcaga
      781 ggtgaccttg cctgaactta aaacagcttt gacagctcaa ttaggcggct ttgtcttcac
      841 atctcctgaa gaaattgctg gagtagagaa ggttggacaa acgaaagcag actttacact
      901 gactgtcaac ggtgtgaagc tagatggaca caagcttgac agtgcatttc aagggacatt
      961 ggaagaagtt tacccaacag aatttaccca agcgaaagaa ctagaagaag taccagctgt
     1021 ggcatcagat gttgtgatta aagccaaaga aaaggttgaa aaacctgtgg tttacatccc
     1081 agtctttcca ggaaccaact cagaatatga ttcagctaag gccttcgaaa aagaaggtgc
     1141 agaggtcaat ttggtgccat tcgtgacctt gaatgaagaa gctattgtca agtcagttga
     1201 aactatggtt gacaatatcg acaagactaa tattctcttc tttgctggtg gattctcggc
     1261 tgcggatgaa ccagatggtt cagctaagtt tatcgtcaat atcctgctta atgaaaaagt
     1321 gtgtgtggct attgatagct ttatcgcccg tggtggtttg attatcggta tttgtaatgg
     1381 attccaagcc ttagtcaaat cgggtctcct accctacgga aactttgaag ctgctaacag
     1441 tactagccca accctcttct acaatgatgc caaccaacac gtggccaaga tggtggaaac
     1501 tcgcattgcc aataccaact caccatggtt ggctggtgtg caagtgggcg atatccacgc
     1561 tattcctgtt tcgcacggtg aagggaagtt tgtcgtgacg gctgaggaat ttgcagagct
     1621 ccgtgacaat ggacaaattt tcagccaata cgttgacttt aacggtaaac caagtatgga
     1681 ttctaagtac aatccgaatg gttctgtcca tgccatcgaa ggaattacca gcaagaatgg
     1741 tcaaatcatc ggtaagatgg gccactcaga acgttatgag gatggtcttt tccaaaatat
     1801 cccaggcaat aaagaccaac acctgttcgc atcagcggtt aaacatttca ctggaaaata
     1861 agacttacag attttctaat agatagtatc agtaatgtaa aagtcatgta aatctagctc
     1921 ttgatgatta caaatgaaaa ttaggtataa aaaatgacat acgaagtaaa atctcttaat
     1981 gaagaatgtg gtgttttcgg tatttgggga catccagatg ctgctaagtt gacctatttt
     2041 ggactccaca gtcttcaaca ccgtggtcag gagggggcag gaatcctctc caatgatcaa
     2101 ggacaactga agcgccatcg tgacatgggg cttttatcag aagttttcag aaatccagcc
     2161 aatttggata aattgacagg agctggtgcg attgggcatg tgcgttatgc gactgctggc
     2221 gaagcttctg ttgataacat ccaacccttc ctcttccgtt ttcacgatat gcagtttggt
     2281 ttggctcata atggaaatct gaccaatgca gcctctctca agaaagaact ggaacaaaga
     2341 ggagcaattt tcagcgcgac ttcggactct gaaatcttgg ctcacctcat tcgtcgcagt
     2401 cataatccta gcctgatggg caaaatcaag gaagcgctca gccttgtcaa aggtggtttt
     2461 gcctatatct tgctgtttga ggacaagttg attgcggctc ttgaccctaa tggctttcgt
     2521 ccgctttcta tcgggaaaat ggccaacgga gcggtggttg tttcctctga aacctgtgct
     2581 tttgaggtca ttggtgccga gtggattcgt gatttgaagc caggtgagat tgtgatcatt
     2641 gatgacgagg gcattcagta tgacagctat acagatgata cccagttggc gatttgttct
     2701 atggagtata tctactttgc ccgccctgat tctaatatcc acggtgtcaa tgtccatacg
     2761 gcacgtaaga gaatgggagc gcaattggcg cgagaattta agcatgaggc agatattgta
     2821 gttggtgtgc ccaattcttc cctaagcgcg gctatgggat ttgcggaaga atcaggctta
     2881 ccaaatgaaa tgggtctgat caaaaaccaa tacacccagc gaacttttat ccaaccgact
     2941 caagaattgc gggagcaagg agtgcggatg aaactgtctg ctgtttcggg tgt
//
LOCUS       DBMVGT010000128         2956 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.128, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000128 DBMVGT010000000
VERSION     DBMVGT010000128.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2956)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2956)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2956
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.128"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1152
                     /gene="bglA"
                     /locus_tag="AC0DU4_002087"
     CDS             <1..1152
                     /gene="bglA"
                     /locus_tag="AC0DU4_002087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000943526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HIN4237989.1"
                     /translation="TSIQWSRIFPQGCGKVNPQGVDFYRKVFEAIKAKGIRLLVNLYH
                     FDLPFALQEDGDGWENKATVSAYEDYARFCFETYGDLVDQWITFNEPIVPVEFGYFYD
                     AHYPHKVDAEAAVKVAYHTQLASSRAVKACHELLPDSKIGIVLNLTPAYPRSQHPADV
                     KAARIAALFQAQSFLDPSVLGTYPQELVEILHEHGLLPDATEEELELIRDNTVDFLGV
                     NYYQPLRVMAPRFAKHPDSPLLPEHFYEPYVMPGRKINSHRGWEIYEQGIYDIAQNIK
                     ENYGNIEWMLTENGMGVEGEEKFRQDGMIQDDYRIDFVKGHLRELHRAIEDGANCKGY
                     LIWTFIDCWSWLNSYKNRYGLVELDLETQERRLKKSGHWFKELSDNNGF"
     gene            1345..>2956
                     /gene="glmS"
                     /locus_tag="AC0DU4_002088"
     CDS             1345..>2956
                     /gene="glmS"
                     /locus_tag="AC0DU4_002088"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014621492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004360 - glutamine-fructose-6-phosphate
                     transaminase (isomerizing) activity [Evidence IEA];
                     GO_process: GO:1901137 - carbohydrate derivative
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HIN4237990.1"
                     /translation="MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHL
                     VKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIE
                     NYFEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFAL
                     VDSQDPEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADS
                     VEVQDYDGNRRERASYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDEAGQ
                     VVVDPDIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPVELGISSEWGYGMPL
                     LSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGP
                     EIAVASTKAYTAQIAALAFLAKAVGEANGNAKAQAFDLVHELSIVAQSIESTLSEKET
                     IEAKVRELLETTRNAFYIGRGQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTIALI
                     EEGTPVLALLSDPVLANHTRGNIQEVAAR"
BASE COUNT          837 a          601 c          678 g          840 t
ORIGIN      
        1 acttctattc agtggtcacg gatttttcca caaggctgtg ggaaagtcaa ccctcaaggt
       61 gtggattttt atcgtaaggt ctttgaggct attaaggcta aaggaattcg tctgttagtc
      121 aatctctatc attttgattt accttttgcc cttcaagagg atggtgatgg ttgggaaaat
      181 aaggcgacag tctcagccta tgaagactat gctcgttttt gttttgagac ttatggagat
      241 ttagtggatc aatggattac ctttaacgag cccatcgttc ctgtagaatt tggttatttt
      301 tatgatgccc attatccaca taaggtggat gcagaggcag ctgttaaggt agcctatcat
      361 acacaattgg ccagcagccg ggctgttaag gcttgccatg aacttttgcc tgattccaag
      421 attgggattg tcctcaactt gacaccggct tatccacgta gccagcatcc tgctgatgtc
      481 aaggcagctc gtattgcggc cctttttcag gcccaatctt tcttagatcc atctgtcttg
      541 gggacttatc cacaggagtt ggtagaaatc ttgcatgaac acggtctttt acctgatgct
      601 acagaggaag agttggaact cattcgtgat aatacggtgg acttccttgg tgtgaactac
      661 tatcaacctt tgcgtgttat ggctcctcga tttgctaagc atccagatag tccactctta
      721 ccagaacatt tttacgagcc ttatgtgatg cctggacgta aaatcaattc tcaccgtggt
      781 tgggagattt atgagcaagg gatttatgac atcgcccaaa atatcaagga aaattatggc
      841 aatattgagt ggatgttgac tgagaatggt atgggtgttg aaggggaaga aaaattccgt
      901 caagatggaa tgattcaaga tgattaccgt attgactttg taaaaggtca tcttcgtgaa
      961 cttcaccgtg ccattgaaga tggtgccaac tgtaagggct acttgatttg gacctttatt
     1021 gactgctggt catggctcaa cagctataaa aatcgctatg gtttggtcga attagacttg
     1081 gaaacgcaag aacgtcgtct gaagaaatca ggccactggt tcaaagaatt aagcgataat
     1141 aatggatttt aaaaaggact ctgactgatt atcccaatcg gtcagagttt ttatgcttac
     1201 aggagcttaa tttgaactat accaattttt actcttgaca agtgaaagaa acaagtatat
     1261 actgtttttg ctgattctat aaaagatgaa ttagactata ccaattttaa ggagaaagca
     1321 cagcttgcct gtgtcgtata tactatgtgt ggaattgttg gtgttgttgg aaacacaaat
     1381 gcaactgata ttttgattca agggcttgaa aagcttgaat accgtggcta tgattctgcg
     1441 ggaatttttg tcctagatgg tgctgataac catttggtga aggctgttgg tcgtattgca
     1501 gaattgtctg ccaagacagc tggtgttgag ggaacaactg gtatcggaca tactcgttgg
     1561 gctactcacg gaaaaccaac tgaggacaat gctcacccac accgctctga gacagaacgt
     1621 tttgtcttgg tgcataatgg ggtgattgag aactactttg aaatcaagga agaatacctt
     1681 gcaggtcacc acttcaaggg gcagacagat actgaaatag ccgttcattt gattggaaaa
     1741 tttgcggaag aagaagggct ctcagttctt gaagccttca aaaaagccct tcacatcatc
     1801 cgtggttctt atgcctttgc cttggttgac tcacaagatc ctgaagtcat ctacgtagct
     1861 aaaaataaat caccactttt gattggtctt ggagaaggct ataacatggt ctgctcagac
     1921 gccatggcta tgattcgtga aactaaccaa tacatggaaa tccatgacca agagttggta
     1981 atcgtcaagg ctgatagtgt ggaagttcaa gactatgatg gaaatcgtcg tgagcgtgct
     2041 agctacactg ctgaacttga cttgtcagat atcggtaagg gaacttaccc ttactatatg
     2101 ctcaaggaaa ttgacgagca accaactgtt atgcggaaac tcatccaagc ctacacagat
     2161 gaggctggtc aagttgtcgt agacccagat atcattaagg ctgttcaaga cgcagaccgc
     2221 atctacatcc ttgcagctgg aacatcttac catgcaggat ttgcttctaa gaaaatgttg
     2281 gaagaattga cagatacacc agttgaactt ggaatctcat ctgagtgggg ctacggtatg
     2341 ccacttctca gcaagaaacc actcttcatc tttatcagcc aatctggtga aacagcggat
     2401 agtcgtcaag ttttggtcaa ggctaatgaa atgggaattc caagcttaac agtgacaaac
     2461 gttccaggtt caaccctctc acgtgaagcc aactatacca tgctccttca cgcaggtcct
     2521 gaaattgccg tggcatcaac taaagcctat acagcgcaaa tcgcagccct tgccttcctt
     2581 gcaaaagcag tcggagaagc aaatggtaat gctaaagcgc aagcctttga cctggttcat
     2641 gaattgtcaa tcgtagctca gtctatcgaa tcaactcttt cagagaaaga aaccattgaa
     2701 gccaaggttc gtgaacttct tgaaacaact cgtaacgcct tttacatcgg acgtggtcaa
     2761 gattactacg tagccatgga agcaagtctc aaactcaaag agatttctta tatccagtgt
     2821 gaaggttttg cggcaggaga actcaagcac ggaaccattg ccttgattga agaaggaacg
     2881 cctgttttgg ctctcttgtc agatccagtt cttgccaacc atactcgtgg aaatatccaa
     2941 gaggtcgcag cccgtg
//
LOCUS       DBMVGT010000129         2852 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.129, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000129 DBMVGT010000000
VERSION     DBMVGT010000129.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2852)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2852)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2852
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.129"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..590
                     /locus_tag="AC0DU4_002089"
     CDS             <1..590
                     /locus_tag="AC0DU4_002089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="glycerol-3-phosphate dehydrogenase C-terminal
                     domain-containing protein"
                     /protein_id="HIN4237991.1"
                     /translation="RGSSLDRDDNGLLTLAGGKITDYRKMAEGAMERVVDILKAEFDR
                     SFKLINSKTYPVSGGELNPANVDSEIEAFAQLGVSRGLDSKEAHYLANLYGSNAPKVF
                     ALAHSLEQAPGLSLADTLSLHYAMRNELALSPVDFLLRRTNHMLFMRDSLDSIVEPVL
                     DEMGRFYDWTEEEKATYRADVEAALANNDLAELKN"
     gene            660..1364
                     /locus_tag="AC0DU4_002090"
     CDS             660..1364
                     /locus_tag="AC0DU4_002090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015267 - channel activity [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MIP/aquaporin family protein"
                     /protein_id="HIN4237992.1"
                     /translation="MMNELFGEFLGTLILILLGNGVVAGVVLPKTKSNSSGWIVITMG
                     WGIAVAVAVFVSGKLSPAHLNPAVTIGVALKGDLPWASVLPYILAQFAGAMLGQILVW
                     LQFKPHYEAEENAGNILATFSTGPAIKDTVSNLISEILGTFVLVLTIFALGLYDFQAG
                     IGTFAVGTLIVGIGLSLGGTTGYALNPARDLGPRIMHSILPISNKGDGDWSYAWIPVV
                     GPVIGAALAVLVFSLF"
     gene            1595..1726
                     /locus_tag="AC0DU4_002091"
     CDS             1595..1726
                     /locus_tag="AC0DU4_002091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="teichoic acid D-Ala incorporation-associated
                     protein DltX"
                     /protein_id="HIN4237993.1"
                     /translation="MKQRKELYLFLGRTALYFLIFLGLLYFFSYLGQGQGSFIYNEF"
     gene            1747..>2852
                     /gene="dltA"
                     /locus_tag="AC0DU4_002092"
     CDS             1747..>2852
                     /gene="dltA"
                     /locus_tag="AC0DU4_002092"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0047473 - D-alanine [D-alanyl carrier
                     protein] ligase activity [Evidence IEA];
                     GO_process: GO:0019350 - teichoic acid biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltA"
                     /protein_id="HIN4237994.1"
                     /translation="MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKSDSDS
                     LAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEV
                     AEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
                     GKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGT
                     LFTLPSVITQDFKQLFAAIFSLPIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDG
                     EELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLATLKRLPIGYTKADS
                     PTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNP"
BASE COUNT          782 a          580 c          641 g          849 t
ORIGIN      
        1 ctcgtgggtc tagcttggac cgtgatgaca atggtctttt gactcttgct ggcggtaaaa
       61 tcacagacta ccgtaagatg gctgaaggag ctatggagcg cgtggttgac atcctcaaag
      121 cagaatttga ccgtagcttt aaattgatca attctaaaac ttaccctgtt tcaggtggag
      181 aattgaaccc agcaaatgtg gattcagaaa tcgaagcctt tgcgcaactt ggagtatcac
      241 gtggtttgga tagcaaggaa gctcactatc tggcaaatct ttacggttca aatgcaccga
      301 aagtctttgc acttgctcac agcttggaac aagcgccagg actcagcttg gcagatactt
      361 tgtcccttca ctatgcaatg cgcaacgagt tggctcttag cccagttgac ttccttcttc
      421 gtcgtaccaa ccatatgctc tttatgcgtg atagcttgga tagcatcgtt gagccagttt
      481 tggatgaaat gggacgattc tatgactgga cagaagaaga aaaagcaact taccgtgctg
      541 atgtcgaagc agctctcgct aacaacgatt tagcagaatt aaaaaattaa gaaaaaataa
      601 aagaggtgga gggcagcatt ccttgtcgct cgtcccttct ttttaatgga gacagaaaga
      661 tgatgaatga attatttgga gaatttctag ggactttaat cctgattctt ctaggaaatg
      721 gtgttgttgc aggtgtggtt cttcctaaaa ccaagagcaa tagctcaggt tggattgtga
      781 ttactatggg ttgggggatt gcagttgcgg ttgcagtatt tgtatctggc aagctcagtc
      841 cagctcattt aaatccagct gtgacaattg gtgtagcttt aaaaggtgac ttgccttggg
      901 cttccgtttt gccttatatc ttagcccagt tcgcaggggc tatgctgggt cagattttgg
      961 tttggttgca attcaaacct cactatgagg cagaagaaaa tgcaggcaat atcctggcaa
     1021 ccttcagtac tggaccagcc atcaaggata ctgtatcaaa cttgattagc gaaatccttg
     1081 gaacctttgt tttggtgttg acaatctttg ctttgggtct ttacgatttt caggcaggta
     1141 tcggaacctt tgcagtgggt accttgattg tcggtatcgg tctatcgcta ggtgggacaa
     1201 caggttatgc cttgaatcct gcgcgtgacc ttggacctcg tatcatgcac agtatccttc
     1261 caatttcaaa caagggagac ggagactggt cttatgcttg gattcctgtt gtgggacctg
     1321 ttatcggtgc agccttggcc gtgcttgtat tctcactttt ttagtttaga aaataactat
     1381 tattgctaga gcttgagatg aaaatctcag gcttttttct tttgaaatag atatagaaaa
     1441 accgcataat ccttaaaata agctgaaatc tattggaaac atacggtaaa caattgaaaa
     1501 gatactatat aaagtggtac aatggtagaa aaataagcta gtaagaatca ctcttatttt
     1561 agcgaaaaat tacagaaatg aatggttttt cttgatgaaa cagagaaaag aattgtacct
     1621 ctttcttggt cggacagcct tgtattttct tatctttcta gggctgcttt acttctttag
     1681 ctatcttggt cagggtcaag gaagctttat ctataatgaa ttttaacttg aaggagaatc
     1741 cctattgtgt caaataaacc aatagcagat atgattgaaa ccattgagca ttttgctcag
     1801 acacagccta gctatcctgt ctataatgtt ttggggcagg aacacactta tggcgattta
     1861 aagtctgatt cggatagttt ggctgcagtc attgaccaac taggcttgcc tgagaagtct
     1921 cctgtggttg tttttggtgg ccaagaatat gaaatgttgg caacctttgt agcgctgact
     1981 aagtcaggtc atgcctacat tccaattgat agccattcgg ccttggagcg agtttcagct
     2041 attttagaag tagcagagcc aagcttgatt attgccattt cagcctttcc cttggagcag
     2101 gtttctacac caatgataaa tctagctcag gttcaagaag cctttgccca agggaacaac
     2161 tatgaaatca cgcatccagt caagggagat gataattact acattatctt tacttctggt
     2221 acgactggta agcctaaggg agtgcagatt tcacatgata atctcctcag ctttacaaac
     2281 tggatgatta cggataagga atttgcgaca ccgagtcgtc cgcaaatgct ggcacagcca
     2341 ccttattctt ttgacttgtc tgtcatgtat tgggcaccga ccttggcact tggtggtacg
     2401 cttttcactc ttccttcagt catcactcag gactttaagc aactctttgc ggctatcttt
     2461 tcattgccaa tcgctatctg gacatcaaca ccatcctttg cagatatggc catgttgtct
     2521 gaatacttca acagtgaaaa aatgcctgga atcacgcatt tctactttga tggtgaagaa
     2581 ttgacggtca aaacagctca aaaactgcgc gagcgtttcc caaatgcccg tatcatcaat
     2641 gcttacggcc caacagaagc gacagtagct ctgtcagcag ttgccgtgac agacgagatg
     2701 ttagcgactc tcaaacgcct accaatcggc tataccaagg ctgattctcc aacctttatc
     2761 attgacgagg aaggaaataa actgccaaat ggcgaacagg gagaaatcat tgtttctggg
     2821 ccagctgttt caaaaggtta tatgaacaat cc
//
LOCUS       DBMVGT010000130         2845 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.130, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000130 DBMVGT010000000
VERSION     DBMVGT010000130.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2845)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2845)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2845
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.130"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..531
                     /locus_tag="AC0DU4_002093"
     CDS             <1..531
                     /locus_tag="AC0DU4_002093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001065636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_component: GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA];
                     GO_process: GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HIN4237995.1"
                     /translation="ARKQSLVFFLIIQMVPTMAALTAFFVMALMLNALNHNWFLIFLY
                     VGGGIPMNAWLMKGYFDTVPMSLDESAKLDGAGHFRRFWQIVLPLVRPMVAVQALWAF
                     MGPFGDYILSSFLLREKEYFTVAVGLQTFVNNAKNLKIAYFSAGAILIALPICILFFF
                     LQKNFVSGLTSGGDKG"
     gene            784..1584
                     /locus_tag="AC0DU4_002094"
     CDS             784..1584
                     /locus_tag="AC0DU4_002094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000938258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1189 domain-containing protein"
                     /protein_id="HIN4237996.1"
                     /translation="MLPYPFSYFSSIWGFRKPLSKRFELNWFQLLFTSIFLISLSMVP
                     IAIQNSSQETYPLETFIDNVYEPLTNEVVQDLSEHATIVDGTLTYTGTASQAPSVVIG
                     PSQIKELPKDLQLHFDTNELVISKESKELTRISYRAIQTESFKSKDSLTQAISKDWYQ
                     QNRVYISLFLVLGASFLFGLNFFIVSLGASLLLYITKKSRLFSFRTFKECYHFILNCL
                     GLPTLITLILGLFGQNMTTLITVQNILFVLYLVTIFYKTHFRDPNYHK"
     gene            1594..2580
                     /locus_tag="AC0DU4_002095"
     CDS             1594..2580
                     /locus_tag="AC0DU4_002095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HIN4237997.1"
                     /translation="MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKEL
                     NYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIAT
                     GKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
                     VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNR
                     IYFADEFLEEKGYKFSKRLFKHDPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDS
                     VNPKLNLAAYVDINSLELGRVSLETILQIINDNKNNKQICYRQLIAHKIIEK"
BASE COUNT          812 a          661 c          508 g          864 t
ORIGIN      
        1 gctcgtaaac aaagtttggt cttcttcttg atcatccaaa tggtgccaac tatggccgct
       61 ttgacagcct tcttcgttat ggcgcttatg ttgaacgccc ttaaccacaa ctggttcctc
      121 atcttcctct acgttggtgg tggtatcccg atgaatgctt ggctcatgaa aggctacttc
      181 gatacagtgc caatgtcttt agacgaatct gcaaaactag acggtgcagg acacttccgc
      241 cgcttctggc aaattgttct accacttgtt cgcccaatgg ttgccgtaca agctctctgg
      301 gccttcatgg gacctttcgg ggactacatc ctctctagtt tcttgcttcg tgagaaagaa
      361 tactttactg ttgccgtagg tctccaaacc ttcgttaaca atgcgaaaaa cttgaagatt
      421 gcctacttct cagcaggtgc tatcctcatc gcccttccaa tctgtattct cttcttcttc
      481 ctacaaaaga actttgtttc aggacttaca agtggtggcg acaagggata atttatcccc
      541 gccacccttt ttcattttat actcttcgaa aatctcttca aaccacgtca gctttatctc
      601 caacctcaaa gttgtgcttt gagcaacctg tggctagttt gcactttgat tttcattgat
      661 tattagcaat tgtcactgta aataatatcc ttgtagcaag caatttttct cctagacttg
      721 aaataaagag catttctcta tataataata ctcatataga aaacaccttt tagaaagata
      781 cctatgcttc catatccatt ttcctatttt tcaagtattt gggggtttcg taagcccctg
      841 tccaaacgtt tcgagctcaa ctggtttcaa cttctcttta ccagtatctt ccttatcagc
      901 ttgtctatgg tacccattgc tatccaaaac agctcccagg agacctatcc gctagaaact
      961 tttatcgata atgtctatga acctctgaca aatgaggttg tccaggatct ctctgaacat
     1021 gctacaattg tcgatggcac attaacttat actggaacag ctagtcaagc cccttctgtt
     1081 gtgattggtc caagtcaaat caaggaatta cctaaggact tgcaactgca tttcgataca
     1141 aatgagctag tcatcagcaa ggaaagcaag gaactgaccc gcatctctta ccgagccatt
     1201 cagactgaga gtttcaaaag caaagacagc ttgacccaag caatttctaa agactggtac
     1261 caacaaaatc gtgtctatat cagcctcttc ctagttctcg gtgcgagctt cctctttggt
     1321 ttgaatttct ttatcgtctc tctaggagct agtcttctcc tttatatcac taagaaatca
     1381 cgcctctttt catttagaac ctttaaagag tgctatcact ttatcttgaa ctgtttagga
     1441 ttgccgactc tgattacact tattttggga ttatttggcc aaaatatgac aaccctgatt
     1501 actgtacaaa atattctttt tgttctgtat ctggtcacta tcttttataa aacacatttc
     1561 cgtgatccaa attaccataa ataggagatt tttatgcccg ttacgattaa agacgtggcc
     1621 aaggctgctg gtgtttcgcc ttcaaccgta acccgtgtta ttcaaaataa atcaaccatt
     1681 agcgacgaaa caaaaaaacg cgttcgcaaa gctatgaagg aactcaacta ccacccaaac
     1741 ctcaacgctc gtagcttggt aagcagctat actcaggtta tcggattagt tcttcctgat
     1801 gactcagacg ccttctacca gaatcctttc tttccatcgg ttctacgtgg catctctcaa
     1861 gtcgcatctg aaaaccacta tgccattcag atagcaacag ggaaagatga gaaggagcgt
     1921 ctcaacgcta tttcacaaat ggtctacggc aagcgtgtag atgggctaat ctttctctat
     1981 gcccaagaag aagaccctct cgtaaaactc gtcgcagaag aacagttccc cttccttatc
     2041 ttaggtaaat ctctatctcc tttcatccca cttgtcgaca acgacaatgt tcaagctggt
     2101 tttgatgcga ctgaatattt catcaaaaaa ggctgcaaac gcattgcctt tatcggagga
     2161 agtaaaaagc tcttcgtgac caaagaccgt ttaacaggct atgaacaggc gcttaaacat
     2221 tacaaactta ccactgacaa caatcgcatc tactttgccg acgagtttct ggaagaaaag
     2281 ggctataaat ttagcaagcg attattcaag cacgatccac aaattgatgc tatcatcaca
     2341 accgatagcc tcctagctga aggtgtttgt aactatattg ccaaacacca gctggatgtc
     2401 cctgttctca gctttgactc ggttaatccc aagctcaact tggcagccta tgtcgatatc
     2461 aatagtttag agcttggtcg tgtttccctt gaaactattc tccagattat taatgataat
     2521 aaaaacaata aacaaatttg ttaccgtcaa ttgatcgccc acaaaattat cgaaaaataa
     2581 gagactgggc aaaaagtcgt taaaagcaaa aacgcatagt atcaggtatt gaaaaaactt
     2641 gatactatgc gttttattgt gggaagattt acttcctttt ctactgaaat tgagttgtta
     2701 cccaagatct ttttatactc aatgaaaatc aaagtgcaaa ctaggaagct agccacaggt
     2761 tgctcaaaac actgttttga ggttgtggat agaactgacg aagtcagctc aaaacatggt
     2821 tttgaggttg tagatgaaac tgacg
//
LOCUS       DBMVGT010000131         2687 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.131, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000131 DBMVGT010000000
VERSION     DBMVGT010000131.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2687)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2687)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2687
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.131"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            50..1138
                     /locus_tag="AC0DU4_002096"
     CDS             50..1138
                     /locus_tag="AC0DU4_002096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="site-2 protease family protein"
                     /protein_id="HIN4237998.1"
                     /translation="MKKIGTYLVYVLAVVFIMLAFACGTIAFAELGYSAVLAFTFGYA
                     FALLSMYLIFILHELGHAFCGYLTGYRLVAFGLGHFILTKKSGRFHLSRTAILKNVGA
                     QYIGLKEDESDQRIILMLSGGLMVHLGLILLAILFGFLTRSWYFAGTWIFLNLSFFLN
                     NILPVDITDGAKIWELLQHPENTKYAYLVLRHSAQTLLAPQEYDLKDFVQAVPEDARG
                     SFADGVLGMQGEVSILEGKEEVAKQQFQALLERTTTPMMQTVAQLSLLHIALLEGDFE
                     QAEQYASIRQVKSFLSLKLSNLQVIQAWYQLKVKKDVDRTRKALKIARQKMDSSRMLR
                     DEKRYYENLLAELEKEMLEGTEDGTRNF"
     gene            1119..1547
                     /locus_tag="AC0DU4_002097"
     CDS             1119..1547
                     /locus_tag="AC0DU4_002097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HIN4237999.1"
                     /translation="MELEISDFPGCKIALFCEDKLLTILRDDKASIPWANMWELPGGG
                     REGDESPFECAAREVYEELGIHLTEDCLLWSKVYPSMLFADKQSVFLVGQLTQNQFDS
                     IVFGDEGQGYQLMNVEEFLSSSQVVPQLQERLKDYLKVSD"
     gene            1685..2635
                     /gene="prmA"
                     /locus_tag="AC0DU4_002098"
     CDS             1685..2635
                     /gene="prmA"
                     /locus_tag="AC0DU4_002098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000451122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HIN4238000.1"
                     /translation="METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSMDYVGNVD
                     RFGEIFPEVEQQEEIVVTAYYPETVDVAAVEADLQARLAELTDFMDLGEVKMGTTALA
                     EEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMS
                     LFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNPG
                     MENIHVAAGDLLKGVEIEADVIVANILADILIHLIDDAYRLVKDEGYLIMSGIIKDKW
                     DMVRESAESAGFFLETHMVQGEWNTCVFKKTKDISGVIGG"
BASE COUNT          738 a          464 c          699 g          786 t
ORIGIN      
        1 gggagaattt tatccttatc caaaatacta ggagttggtt ggaggtgtta tgaagaaaat
       61 tgggacttat ttggtttatg tgctagctgt tgtctttatt atgctagctt ttgcttgtgg
      121 aacaatcgca tttgcagagt tggggtattc cgcagtttta gcctttactt ttggttatgc
      181 cttcgctctt ctaagcatgt atttaatctt tattcttcat gagctgggtc atgctttttg
      241 tggctacttg acaggctatc ggctggtggc ttttggatta ggacatttta ttttgaccaa
      301 aaagtcaggc aggtttcatc ttagtagaac agccattctg aaaaatgttg gtgctcaata
      361 cattggttta aaagaggatg aaagcgatca aagaatcatc ctgatgcttt caggaggctt
      421 gatggttcat ctcggcttga tattattggc gatattgttt ggatttttga caagaagctg
      481 gtattttgca gggacttgga tttttcttaa tttatctttc ttcctaaata acattttgcc
      541 agtcgacatc accgatggag caaaaatttg ggaattacta caacaccctg aaaataccaa
      601 atacgcctac ctggtattga gacattctgc tcaaactttg ctggctcctc aagaatatga
      661 tttgaaagac tttgttcaag cagttcctga ggatgcacga gggagttttg cggatggtgt
      721 attaggtatg caaggtgaag tttccatttt ggaagggaag gaagaagtag ctaaacagca
      781 gtttcaagca ttacttgaga ggacaactac tccgatgatg cagacagttg cccaactatc
      841 cctgcttcat atcgccttgt tggaaggaga ttttgagcaa gcggagcaat atgctagtat
      901 tcgacaggtc aaatcgtttc tgtctctcaa actgtccaat cttcaagtga tacaagcctg
      961 gtatcaatta aaggtgaaga aagatgtaga tcgaactcgt aaggctctca agattgctag
     1021 acagaaaatg gatagtagtc gaatgttgag ggacgagaaa cgctattatg aaaacttgtt
     1081 agcagagctg gaaaaggaaa tgttagaagg aactgaagat ggaactagaa atttctgatt
     1141 tcccaggctg taagattgct ttgttttgtg aggataagct cttgactatc ttacgtgatg
     1201 ataaggcaag cattccctgg gccaatatgt gggaactgcc aggtggggga cgtgaaggtg
     1261 atgaaagtcc ttttgagtgc gcggcgcgtg aagtttatga agaactgggc attcatctga
     1321 ctgaagattg tctgctttgg agtaaggttt atccaagtat gctttttgcg gataaacaat
     1381 ctgtatttct agttggtcag ttgacacaga accagtttga cagtatcgta tttggagatg
     1441 aaggacaggg ctatcagctg atgaatgttg aggaatttct tagttccagt caagttgtcc
     1501 ctcagttgca agagagatta aaagattatt taaaagtaag tgattagaaa ggatggttcg
     1561 gttaaatttc taaactgaac ccgccctaaa cacggtgcca aaaagataaa cttctcttag
     1621 acacaaacgt cttcagagag ttacctattt tggctttgtg ttttacgggc ttggtatctt
     1681 aataatggaa acatggcaag agttaaaagt tacagtgaag cgtgagggag aggagttggt
     1741 ttccaatctc ttgattgagt taggtgccca aggggtagca attgaagaca gcatggacta
     1801 tgtgggaaat gtggaccgat tcggtgaaat tttcccagag gtggagcaac aggaagaaat
     1861 cgtagtgacc gcctactacc ctgaaacggt tgatgtagca gcagttgaag cggatttgca
     1921 ggctcgtctg gcagaattga ccgactttat ggacctagga gaagtcaaga tgggcacgac
     1981 tgccttggct gaggaagact gggctgacaa ctggaagaag tattatgaac cggcacgcat
     2041 cacccatgac ctgaccatcg taccgtcatg gacggactat gaggcaacag caggagaaaa
     2101 aattatcaag ctggatcctg gcatggcttt tggtactgga acccacccaa ctaccaagat
     2161 gagccttttt gccttggaac aggttcttcg tggtggcgaa acggtgctag atgtggggac
     2221 tggttcaggg gttctctcta ttgccagctc gcttctgggg gctaaagaaa ttttcgccta
     2281 tgacctggat gatgtggcgg ttcgtgtggc tcaggaaaat attgagctca accctggcat
     2341 ggaaaatatc catgtagcgg ctggagattt gcttaagggt gtggaaattg aggcagatgt
     2401 gattgtggct aatatcttgg cggatatcct cattcatcta atagacgatg cctatcgttt
     2461 ggttaaggac gaaggctacc tgatcatgag tggcattatc aaggataagt gggacatggt
     2521 gcgcgagtcg gctgaatcag ctggattttt cctcgaaact cacatggttc aaggggaatg
     2581 gaatacctgt gtctttaaga aaaccaagga tatctctggt gtgattggag gctagcatgc
     2641 agcagtattt tgtaaaaggc agtgctatct ctcctgtcac tatcgag
//
LOCUS       DBMVGT010000132         2558 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.132, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000132 DBMVGT010000000
VERSION     DBMVGT010000132.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2558)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2558)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2558
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.132"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..141)
                     /locus_tag="AC0DU4_002099"
     CDS             complement(<1..141)
                     /locus_tag="AC0DU4_002099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002920493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination protein O N-terminal
                     domain-containing protein"
                     /protein_id="HIN4238001.1"
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQS
                     KLA"
     gene            complement(138..1307)
                     /locus_tag="AC0DU4_002100"
     CDS             complement(138..1307)
                     /locus_tag="AC0DU4_002100"
                     /EC_number="2.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HIN4238002.1"
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTT
                     PDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATE
                     ALSATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAI
                     LEQGDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAH
                     VSLGTMLKDQAIIINGLSKSHAMTGWRLGLIFAPAAFTAQLIKSHQYLVTAANTMAQH
                     AAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQD
                     SFAFLKDFAQKKAVAFIPGAAFGRYGEGYVRLSYAASMETIKEAMKRLEEYMREA"
     gene            1456..2466
                     /locus_tag="AC0DU4_002101"
     CDS             1456..2466
                     /locus_tag="AC0DU4_002101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YeiH family protein"
                     /protein_id="HIN4238003.1"
                     /translation="MSFLSKNGAGILACLLISIVSWYLGGFFPVIGAPVFAIFIGMLL
                     HPFLSSYKQLDAGLTFSSKKLLQYAVVLLGFGLNISQVFAVGQSSLPVILSTISIALI
                     IAYLFQRFFALDTKLATLVGVGSSICGGSAIAATAPVINAKEKEVAQAISVIFFFNVL
                     AALIFPTLGTWLHLSNEGFALFAGTAVNDTSSVTAAASAWDSLYQSNTLESATIVKLT
                     RTLAIIPITLFLSYWQSRQQENKQSLQLKKVFPLFILYFILASLLTTLLTSLGVSSSF
                     FTPLKELSKFLIVMAMSAIGLKTNLVAMVKSSGKSILLGAICWIAIILTTLGMQTLIG
                     IF"
BASE COUNT          646 a          673 c          480 g          759 t
ORIGIN      
        1 cgccagctta gactgaccag cgtgtttgac aaaaaacatg cgtttgccaa cctgctctgt
       61 aaaaattttg acgagcttgt catcctcacg aaaattgcga ttgtaaagca ccaagccttg
      121 actcgtgata gactgaatca tgcttctctc atgtactcct caagtcgttt catggcttct
      181 ttgatagtct ccatgctggc tgcataagat aggcggacgt agccttcccc gtaacgtcca
      241 aaggctgcac cagggataaa ggcaacggcc ttcttctgag caaaatcctt cagaaaagca
      301 aaggagtctt gattgtagcc cgctggaatt ttagcaaaaa tatagaaggc accgtctggt
      361 ttgataatct caaaaccaag agcagtcatt ttttcgatga tatagtcccg acgctggata
      421 tattccttct tcatgggctc cgcatcattt ttaccagccg tcaaggcttc taccgcagca
      481 tgttgcgcca tggtatttgc ggcagtgacc aagtattggt gactcttgat taactgggct
      541 gtgaaggccg caggagcgaa aatcagcccc aaacgccaac ctgtcatggc atgcgattta
      601 gacaaaccat tgataataat agcctggtct ttcaacatcg ttcctagaga cacatgggct
      661 tcgcctgtgt aggtcaattc tgagtaaacc tcatcacaga caacaaaaat ttcgtacttg
      721 cgtaaaacag ctgccaaggc ctctaactgc tctcgactgt aggtaattcc tgtcggattg
      781 gctggatagt tgagaataac cgctttgagc ttatcaccct gctccaaaat ggccttctcc
      841 aacatctcag gagtcaagac aaaaccattt tcagtcgtat caatctcaac aatttctgcc
      901 ccaactaagt taacaatcgg ttcatagcct ggataagcag gagctggcaa aagtaccttg
      961 tctccctctt ccaaaatagc cgtcaaagtc gcagataaag cctctgtcgc cccaattgta
     1021 accaagattt cattttcagg agcatagtcc agttggtact tttccttaac aaagtcacta
     1081 gctgcctgac gtagagtcag cagaccactc atccctgtat agtaggattg gttctgatca
     1141 atcgctcgct tggccgcctc cttgacatgg tctggcgttg taaaatcagg ttcccccaag
     1201 gtcaaacgca agaccccagg aatctccgaa atagcctggt caaactgacg aatcaacgaa
     1261 acttgaatct tatctaactg tttattaaag cgcttagtta agtccataga tacctcctac
     1321 tttcaaaacg tatctctatt atactacaaa agcctcccga ccgcaaaaat acattagaga
     1381 atagctttcc actttctatt ttacttttcc tgtttatagg tctataatgg taatagattt
     1441 tatttggagg tttttatgtc atttctatca aaaaatggag caggtatctt ggcctgcctt
     1501 ctcatttcta tcgtatcttg gtacttagga ggattcttcc ctgtgattgg cgcgcccgtt
     1561 tttgccattt tcataggcat gctcctacat ccctttctct cgtcctataa acaactggat
     1621 gctggtttga cctttagttc caagaagttg ctccaatatg ccgttgtctt gcttggtttt
     1681 ggtctcaata tctcgcaggt cttcgcagtt ggccaatctt cactccctgt catcctgtcc
     1741 actatctcaa tagctctgat tattgcctac ctcttccagc gtttctttgc actggataca
     1801 aaactggcta ccttggttgg agtaggttct tctatctgtg ggggttctgc cattgcagcg
     1861 acagcgcccg ttattaatgc taaggaaaag gaagtagccc aagccatttc cgttatcttt
     1921 ttcttcaatg tcttggctgc gctcatcttt ccaaccctcg gcacctggct tcatctatcc
     1981 aatgaaggct tcgccctctt tgcagggact gcggtcaacg acacttcctc tgtaacggct
     2041 gccgccagcg cttgggacag tctttaccaa agcaataccc tcgagtctgc aaccattgtt
     2101 aaactcacac gtactttggc cattatccct atcacgctct ttctatccta ctggcaaagt
     2161 cgccaacaag aaaacaagca aagcctacaa ctgaaaaaag tcttcccact ttttatcctt
     2221 tactttatcc ttgcctctct cctcactaca ctactcacct ctctaggtgt gtccagtagt
     2281 ttctttaccc ctctcaaaga actctctaaa ttccttattg tcatggccat gagtgctatc
     2341 ggtctcaaaa ccaatctggt cgctatggtc aaatccagtg gaaaatccat tcttcttgga
     2401 gccatctgct ggattgccat catcctcacc actcttggta tgcagaccct tatcggcatt
     2461 ttctaacact cttcgaaaat ctcttcaaac cacgtcaacg tcgccttgcc gtaggtatat
     2521 gttactgact tcgtcagttc tatctgcaac ctcaaaac
//
LOCUS       DBMVGT010000133         2527 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.133, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000133 DBMVGT010000000
VERSION     DBMVGT010000133.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2527)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2527)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2527
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.133"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..546
                     /locus_tag="AC0DU4_002102"
     CDS             <1..546
                     /locus_tag="AC0DU4_002102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl hydrolase-related protein"
                     /protein_id="HIN4238004.1"
                     /translation="QAFVSLYDDEKGVTVSNKGLNEYEILGDNTIAVTILRASGELGD
                     WGYFPTPEAQCLREFEVEFALECHQAQERFSAYRRAKALQTPFTSLQLARQEGSVVAT
                     GSLLSHSVLSIPQVCPTAFKVAENEEGYVLRYYNMSQENVRISEHQQTILDLLERPYP
                     VHSGLLAPQEIRTEFIKKEEI"
     gene            630..1499
                     /locus_tag="AC0DU4_002103"
     CDS             630..1499
                     /locus_tag="AC0DU4_002103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HIN4238005.1"
                     /translation="MTIATIDIGGTGIKFASLTPDGKILYKTSISTPENLEDLLAWLD
                     QRLSEQDYSGIAMSVPGAVNQETGVIDGFSAVPYIHGFSWYEALSSYQLPVHLENDAN
                     CVGLSELLAHPELENAACVVIGTGIGGAMIINGRLHRGRHGLGGEFGYMTTLAPAEKL
                     NNWSQLASTGNMVRYVIEKSGHTDWDGRKIYQEAAAGNALCQEAIERMNRNLTQGLLN
                     IQYLIDPDVISLGGSISQNPDFIQGVKKAVEDFVDAYEEYTVAPVIQTCTYHADANLY
                     GALVNWLQEEKQW"
     gene            1493..>2527
                     /locus_tag="AC0DU4_002104"
     CDS             1493..>2527
                     /locus_tag="AC0DU4_002104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HIN4238006.1"
                     /translation="MVRFTGLSPKQTQAIEVLKGHISLPDVEVAVTQSDQASISIEGE
                     EGHYQLTYRKPHQLYRALSLLVTVLAEADKVEIEEQAAYEDLAYMVDCSRNAVLNVAS
                     AKQMIEVLALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEAYAQQFDMTF
                     VPCIQTLAHLSAFVKWGVKEVQELRDVEDILLIGEEKVYDLIDGMFATLSKLKTRKVN
                     IGMDEAHLVGLGRYLILNGVVDRSLLMCQHLERVLDIADKYGFHCQMWSDMFFKLMSA
                     DGQYDRDVEIPEETRVYLDRLKDRVTLVYWDYYQDSEEKYNRNFRNHHKISHDLAFAG
                     GAWKWIGFTPH"
BASE COUNT          698 a          546 c          620 g          663 t
ORIGIN      
        1 caagcttttg tcagtctgta tgacgatgaa aaaggggtga ctgtatccaa taagggattg
       61 aatgaatacg aaatccttgg ggataacacc attgccgtga ccattttgcg tgcatcaggt
      121 gagctaggtg actggggcta cttcccaacg ccagaagcac aatgcttgcg tgagtttgaa
      181 gtcgagtttg cacttgaatg ccaccaagcc caagaacgct tctcagccta tcgtcgtgcc
      241 aaagccttgc agacaccgtt taccagcctt cagcttgcta gacaggaagg aagcgtggtt
      301 gcgactggta gcctcttgag ccattctgtt ctcagcatac cgcaagtttg tccaacagcc
      361 tttaaagtgg cggaaaatga agaaggctat gtcctccgtt actataatat gagtcaagaa
      421 aatgtgcgca tatcagaaca tcaacaaacc attcttgact tacttgagcg accatatcca
      481 gttcattcag gactattggc tccacaagag attcgtacag aattcatcaa aaaagaagaa
      541 atttaatttc aaaaagtaaa catcaaaaga aaggaggggc gaaaaagtaa gaactaactg
      601 ctgattcgcc cctttttatg gtaaaaacaa tgaccattgc aacgattgat atcggaggga
      661 ctgggattaa gtttgccagt ctgactcctg atgggaaaat actgtataag acaagtattt
      721 caacgcctga aaacttggag gatttactag cgtggctaga tcaacgcttg tcagaacagg
      781 attacagtgg gattgctatg agcgttccag gtgcggtcaa tcaagagaca ggtgtgattg
      841 atggcttcag tgcggtgccc tacatccatg gcttttcttg gtatgaggcg cttagctctt
      901 atcagctacc tgtccattta gaaaatgatg ccaactgcgt tggactcagt gaactactag
      961 ctcatccaga gcttgaaaat gcagcctgtg tcgtgattgg gacagggatt ggcggagcca
     1021 tgattatcaa tggtagactt catcgaggtc gccacggtct gggtggagaa tttggctaca
     1081 tgacaaccct tgcccctgct gaaaaactta ataactggtc gcaactagca tcaactggga
     1141 atatggtacg atacgtgatt gaaaaatctg gtcatactga ttgggacggt cgcaagattt
     1201 accaagaggc cgcagctggt aatgctcttt gtcaagaagc cattgagcgc atgaaccgca
     1261 atctgacgca aggcttgctc aatatccagt atctgatcga tccagatgtc atcagtctgg
     1321 gtggctctat cagtcaaaat ccagatttta tccaaggtgt taagaaggct gttgaagact
     1381 ttgtcgatgc ctacgaagaa tacacggtcg caccagttat ccagacctgc acctatcacg
     1441 cagatgccaa tctctacggt gcccttgtca actggctaca ggaggaaaag caatggtaag
     1501 atttacagga cttagtccca aacaaacgca agctattgag gttttaaaag gtcatatttc
     1561 tctaccagat gtggaagtgg ctgtcactca gtctgaccaa gcctctatct ctatcgaggg
     1621 tgaggaaggt cactatcaat tgacctaccg caaacctcac caactttatc gtgccttatc
     1681 cttgttggta acagttctag cagaagctga taaagtagag attgaggaac aagcagctta
     1741 cgaagatttg gcttacatgg ttgactgttc tcgaaatgcg gtgctgaatg tggcttctgc
     1801 caagcagatg attgaggtct tggctctcat gggctactca acctttgagc tttacatgga
     1861 agacacttac cagattgaag gacagcctta ctttggctat ttccgtggag cttattcagc
     1921 agaggagttg caggaaatcg aagcctatgc ccaacagttt gacatgacct ttgtaccatg
     1981 catccagacc ttggcccact tgtcggcctt tgtcaaatgg ggtgtcaagg aagtccagga
     2041 gctccgtgat gtagaggaca ttcttctcat tggcgaagaa aaggtttatg acctgattga
     2101 tggcatgttt gccacgttgt ctaaactgaa gactcgcaag gtcaatatcg ggatggacga
     2161 agcccacttg gttggtttgg gacgctacct gattttgaac ggtgttgtgg atcgtagtct
     2221 cctcatgtgc caacacttgg agcgcgtgct ggatattgct gacaaatatg gtttccactg
     2281 ccagatgtgg agtgatatgt tcttcaaact catgtcagcg gatggccagt acgaccgtga
     2341 tgtggaaatt ccagaggaaa ctcgtgtcta cctagaccgt ctcaaagacc gtgtgactct
     2401 ggtttactgg gattattatc aggatagcga ggaaaaatac aaccgtaatt tccgcaatca
     2461 tcacaagatt agccatgacc ttgcatttgc agggggagct tggaagtgga ttggctttac
     2521 acctcac
//
LOCUS       DBMVGT010000134         2496 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.134, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000134 DBMVGT010000000
VERSION     DBMVGT010000134.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2496)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2496)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2496
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.134"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..125
                     /locus_tag="AC0DU4_002105"
     CDS             <1..125
                     /locus_tag="AC0DU4_002105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HIN4238007.1"
                     /translation="QLRKLLGLDVEIKLSKKDSGKIIISFSNQEEYSRIINSLK"
     gene            338..1699
                     /gene="dnaA"
                     /locus_tag="AC0DU4_002106"
     CDS             338..1699
                     /gene="dnaA"
                     /locus_tag="AC0DU4_002106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003688 - DNA replication origin binding
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006270 - DNA replication initiation
                     [Evidence IEA];
                     GO_process: GO:0006275 - regulation of DNA replication
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HIN4238008.1"
                     /translation="MKEKQFWNRILEFAQERLTRSMYDFYAIQAELIKVEENVATIFL
                     PRSEMEMVWEKQLKDIIVVAGFEIYDAEITPHYIFTKPQDTTSSQVEEATNLTLYDYS
                     PKLVSIPYSDTGLKEKYTFDNFIQGDGNVWAVSAALAVSEDLALTYNPLFIYGGPGLG
                     KTHLLNAIGNEILKNIPNARVKYIPAESFINDFLDHLRLGEMEKFKKTYRSLDLLLID
                     DIQSLSGKKVATQEEFFNTFNALHDKQKQIVLTSDRSPKHLEGLEERLVTRFSWGLTQ
                     TITPPDFETRIAILQSKTEHLGYNFQSDTLEYLAGQFDSNVRDLEGAINDITLIARVK
                     KIKDITIDIAAEAIRARKQDVSQMLVIPIDKIQTEVGNFYGVSIKEMKGSRRLQNIVL
                     ARQVAMYLSRELTDNSLPKIGKEFGGKDHTTVIHAHAKIKSLIDQDDNLRLEIESIKK
                     KIK"
     gene            1858..>2496
                     /gene="dnaN"
                     /locus_tag="AC0DU4_002107"
     CDS             1858..>2496
                     /gene="dnaN"
                     /locus_tag="AC0DU4_002107"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009360 - DNA polymerase III complex
                     [Evidence IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HIN4238009.1"
                     /translation="MIHFSINKNLFLQALNTTKRAISSKNAIPILSTVKIDVTNEGIT
                     LIGSNGQISIENFISQKNEDAGLLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQN
                     QIVLTSGKSEITLKGKDSEQYPRIQEISASTPLILETKLLKKIINETAFAASTQESRP
                     ILTGVHFVLSQHKELKTVATDSHRLSQKKLTLEKNSDDFDVVIPSRSLREFSA"
BASE COUNT          886 a          422 c          406 g          782 t
ORIGIN      
        1 aacagttaag aaaactactc ggattagatg tagaaattaa actatctaaa aaagacagtg
       61 gaaaaatcat tatttctttt tcaaatcaag aagaatatag tagaattatc aacagcctga
      121 aataaggctg ttcttttatt tttttatctc acaaggttat ccactatgtt tttcgataaa
      181 aagcttaata aatcaataat ttcttctttt atccccaacc tgtggataaa gtttagtaac
      241 attgtggatt atttttcaca gcttgtggaa aattcttgct atctatggta aaatatctct
      301 agtattaaac ttttaaatag taaaggagga gaaaggattg aaagaaaaac aattttggaa
      361 tcgtatatta gaatttgcac aagaaagact gactcgatcc atgtatgatt tctatgctat
      421 tcaagctgaa ctcatcaagg tagaggaaaa tgttgccact atatttctac ctcgctctga
      481 aatggaaatg gtctgggaaa aacaactaaa agatattatt gtagtagctg gttttgaaat
      541 ttatgacgct gaaataactc cccactatat tttcaccaaa cctcaagata cgactagctc
      601 acaagttgaa gaagctacaa atttaactct ttatgactat agtccaaagt tagtatctat
      661 tccttattca gatacgggat taaaagaaaa gtataccttt gataacttta ttcaagggga
      721 tggaaatgtt tgggctgtat cagccgcttt agctgtctct gaagatttgg ctctgaccta
      781 taaccctctt tttatctatg gaggaccagg ccttggtaag actcacttat taaacgctat
      841 tggaaatgaa attctaaaaa atattcctaa tgcgcgtgtt aaatatatcc ctgccgaaag
      901 ctttattaat gactttcttg atcacctaag acttggggaa atggaaaagt ttaaaaagac
      961 ctatcgtagt cttgatcttt tgttaatcga tgatatccag tcactcagcg gaaaaaaagt
     1021 cgcaactcag gaagaatttt tcaatacctt taacgccctt catgacaagc aaaaacagat
     1081 tgtcctaacg agtgatcgta gtccaaaaca tctagaaggg ctcgaggaga ggcttgtcac
     1141 gcgttttagt tggggattga cacaaactat cacaccccct gactttgaaa cacgtattgc
     1201 cattttacaa agtaaaacgg aacatttagg ctacaatttc caaagtgata ctctagaata
     1261 cctagctggg caatttgatt caaatgttcg agatcttgag ggagccatca acgacatcac
     1321 tttaattgcc agagtaaaaa aaatcaagga tatcactatt gatattgctg cagaagccat
     1381 tagagcccgc aaacaagatg ttagccaaat gctcgtcatc ccaattgata aaatccaaac
     1441 tgaagttggt aacttttatg gtgttagtat caaagaaatg aagggaagta gacgccttca
     1501 aaatattgtt ttggcccgtc aagtagccat gtatttatct agagaactaa cagataatag
     1561 tcttccaaaa attgggaagg aatttggggg aaaagatcat accacagtca ttcatgccca
     1621 tgccaaaata aaatctttga ttgatcaaga cgataattta cgtttagaaa ttgaatcaat
     1681 caaaaagaaa atcaaataat ttgtggataa cttttagttt tttatctttt ttatccacat
     1741 tttttaaaca agctaaaaaa cttgatatga cttgtttaaa ggctgttttc cacagatttc
     1801 acagactcta ttattactat tatctttcta atactaaaaa taaataaagg agaatccatg
     1861 attcattttt caattaataa aaatttattt ctacaagcat taaatactac taagagagct
     1921 attagttcta aaaatgccat tcctatttta tcaacagtaa aaattgacgt gaccaatgaa
     1981 ggtattactt taattggttc aaatggtcaa atttcaattg aaaattttat ttctcaaaaa
     2041 aatgaagatg ctggtttgtt aattacttct ttaggttcga tccttcttga agcttctttc
     2101 tttatcaatg tagtatctag tttacctgat gtaactcttg attttaaaga aattgaacaa
     2161 aatcaaattg ttttaaccag tggcaaatca gaaattaccc taaaaggaaa agatagcgaa
     2221 caatatccac gaatccaaga aatttcagca agcactcctt taatacttga aacaaaatta
     2281 ctcaagaaaa ttattaatga aacagccttt gctgcaagta cacaagagag tcgtccgatt
     2341 ttaacaggtg tccacttcgt attgagtcaa cacaaagagt taaaaacagt tgcaacagac
     2401 tctcatcgcc taagccagaa aaaattgact cttgaaaaaa atagtgatga ttttgatgtc
     2461 gtaattccta gccgttctct acgcgaattt tcagcg
//
LOCUS       DBMVGT010000135         2428 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.135, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000135 DBMVGT010000000
VERSION     DBMVGT010000135.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2428)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.135"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            23..1540
                     /gene="malQ"
                     /locus_tag="AC0DU4_002108"
     CDS             23..1540
                     /gene="malQ"
                     /locus_tag="AC0DU4_002108"
                     /EC_number="2.4.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004134 - 4-alpha-glucanotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0005980 - glycogen catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="4-alpha-glucanotransferase"
                     /protein_id="HIN4238010.1"
                     /translation="MKKRQSGVLMHISSLPGAYGIGSFGQSAYDFVDFLVRTKQRYWQ
                     ILPLGATSYGDSPYQSFSAFAGNTHFIDLDILVEQGLLEASDLEGVDFGSDASEVDYA
                     KIYYARRPLLEKAVKRFFEVGDVKDFEKFAQDNQSWLELFAEYMAIKEYFDNLAWTEW
                     PDADARARKASALESYREQLADKLVYHRVTQYFFFQQWLKLKAYANDNHIEIVGDMPI
                     YVAEDSSDMWANPHLFKTDVNGKATCIAGCPPDEFSVTGQLWGNPIYDWEAMDKDGYK
                     WWIERLRESFKIYDIVRIDHFRGFESYWEIPAGSDTAAPGEWVKGPGYKLFAAVKEEL
                     GELNIIAEDLGFMTDEVIELRERTGFPGMKILQFAFNPEDESIDSPHLAPANSVMYTG
                     THDNNTVLGWYRNEIDDATREYMARYTNRKEYETVVHAMLRTVFSSVSFMAIATMQDL
                     LELDEAARMNFPSTLGGNWSWRMTEDQLTPAVEEGLLDLTTIYRRINENLVDLKK"
     gene            1566..>2428
                     /locus_tag="AC0DU4_002109"
     CDS             1566..>2428
                     /locus_tag="AC0DU4_002109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000950172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008184 - glycogen phosphorylase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan phosphorylase"
                     /protein_id="HIN4238011.1"
                     /translation="MLSLQEFVQNRYNKTIAECSNEELYLALLNYSKLASSQKPVNTG
                     KKKVYYISAEFLIGKLLSNNLINLGLYDDVKKELAAAGKDLIEVEEVELEPSLGNGGL
                     GRLAACFIDSIATLGLNGDGVGLNYHFGLFQQVLKNNQQETIPNAWLTEQNWLVRSSR
                     SYKVPFADFTLTSTLYDIDVTGYETATKNRLRLFDLDSVDSSIIKDGINFDKTDIARN
                     LTLFLYPDDSDRQGELLRIFQQYFMVSNGAQLIIDEAIEKGSNLHDLADYAVVQINDT
                     HPSMVIPELIRL"
BASE COUNT          716 a          494 c          523 g          695 t
ORIGIN      
        1 ttttaacaca cgaggtgcta ttatgaaaaa acgtcaaagt ggtgtgttga tgcacatctc
       61 ttctcttcca ggagcttacg gaatcggatc atttggtcaa agtgcttacg acttcgttga
      121 tttcttggtc cgtacaaaac aacgttactg gcaaatcctt ccattaggag caactagtta
      181 cggggattct ccttaccaat ctttctcagc cttcgcagga aacactcatt ttatcgattt
      241 agatatcttg gtggagcaag gtttgttgga agcaagtgac cttgaaggag ttgactttgg
      301 tagcgatgcg tctgaagttg actatgctaa aatctactat gcacgtcgtc ctcttttaga
      361 aaaagcggtg aaacgtttct ttgaagtcgg agatgttaaa gattttgaga aatttgctca
      421 agacaaccaa tcatggcttg agctctttgc tgagtatatg gctatcaaag agtattttga
      481 caatcttgct tggactgaat ggccagatgc agatgctcgt gctcgtaaag cttcagcact
      541 tgaaagctat cgtgagcaat tggcagacaa gttggtttac caccgtgtga ctcaatactt
      601 cttcttccaa caatggttga aattgaaagc ttacgctaac gacaaccaca tcgaaatcgt
      661 tggggacatg ccaatctacg tagcggaaga ttcaagtgat atgtgggcaa atccacatct
      721 cttcaaaaca gatgtcaatg gtaaggctac ttgtatcgca ggatgcccac cagatgagtt
      781 ttctgtaact ggtcagcttt ggggtaatcc aatctatgac tgggaagcaa tggacaaaga
      841 cggctacaaa tggtggattg aacgcttgcg tgaaagcttc aaaatctacg atatcgttcg
      901 tatcgaccac ttccgtggct tcgaatctta ctgggaaatc cctgctggtt ccgatacagc
      961 agcacctggt gagtgggtga aaggtccagg ctacaagctt tttgcagccg ttaaggaaga
     1021 acttggtgag ctaaacatca tcgcagaaga ccttggcttc atgacagatg aagtgatcga
     1081 attgcgtgaa cgtactggct tcccaggaat gaagattctt caatttgcct tcaacccaga
     1141 agacgaaagc attgatagcc cacacttggc acctgctaac tcagttatgt acacaggaac
     1201 acacgataac aatacggttc ttggttggta ccgtaatgag attgatgatg cgactcgtga
     1261 gtacatggct cgttacacga accgtaaaga atacgaaaca gtggtacacg ctatgcttcg
     1321 tacagtattt tcatcagtta gctttatggc aattgcaact atgcaagatt tactagaatt
     1381 ggatgaggca gctcgtatga acttcccatc tacccttggt ggaaactggt cttggcgtat
     1441 gactgaagat caattgacac cagctgtcga ggaaggtttg cttgacttga caacaattta
     1501 tcgccgaatt aatgaaaatt tggtagattt aaagaaataa gacaataatc aggagacaac
     1561 taaacatgtt atcactacaa gaatttgtac aaaatcgtta caataaaacc attgcagaat
     1621 gtagcaatga agagctttac cttgctcttc ttaactacag caagcttgca agcagccaaa
     1681 aaccagtcaa cactggtaag aaaaaagttt actacatctc agctgagttc ttgattggta
     1741 aactcttgtc aaacaacttg attaaccttg gtctttacga cgatgttaaa aaagaacttg
     1801 cagctgcagg taaagacttg atcgaagttg aagaagttga attggaacca tctcttggta
     1861 atggtggttt gggacgtttg gctgcctgct ttatcgactc aattgctact cttggtttga
     1921 atggtgacgg tgttggtctt aactaccact ttggtctttt ccaacaagtt cttaaaaaca
     1981 accaacaaga aacaattcca aatgcatggt tgacagagca aaactggttg gttcgctcaa
     2041 gccgtagcta caaagtacca tttgcagact ttactttgac atcaactctt tacgatattg
     2101 atgttactgg ttatgaaaca gcgactaaaa accgcttgcg tttgtttgac ttggattcag
     2161 ttgattcttc tattattaaa gatggtatca actttgacaa gacagatatc gctcgcaact
     2221 tgactctctt cctttaccca gatgatagtg accgtcaagg tgaattgctc cgtatcttcc
     2281 aacaatactt catggtttca aacggtgcgc aattgatcat cgacgaagca atcgaaaaag
     2341 gaagcaactt gcatgacctt gctgactacg cagttgtcca aatcaacgat actcacccat
     2401 caatggtgat tcctgaattg attcgtct
//
LOCUS       DBMVGT010000136         2343 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.136, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000136 DBMVGT010000000
VERSION     DBMVGT010000136.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2343)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.136"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            51..494
                     /locus_tag="AC0DU4_002110"
     CDS             51..494
                     /locus_tag="AC0DU4_002110"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HIN4238012.1"
                     /translation="MKIRGFELVSSFTDENLLPKRETAHAAGYDLKVAVRTVVAPGEI
                     VLVPTGVKAYMQPTEVLYLYDRSSNPRKKGLVLINSVGVIDGDYYGNPGNEGHIFAQM
                     KNITDQEVVLEVGERIVQAVFATFLIADGDAADGVRTGGFGSTGH"
     gene            496..1011
                     /locus_tag="AC0DU4_002111"
     CDS             496..1011
                     /locus_tag="AC0DU4_002111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HIN4238013.1"
                     /translation="MKIIFVRHGEPDYRELEERSYIGFGIDLAPLSEMGRQQVQKLSK
                     NPLLSSAEIIVSSAVTRALETASYVVCATGLPLRVEPLLHEWQVYKTGIENFETARRL
                     FLENKGELLPNSPIQYETATEMKSRFLECMSKYREHQTVVVVAHRMLMRQFVPNEKID
                     FCQVIECELEI"
     gene            1025..>2343
                     /gene="radA"
                     /locus_tag="AC0DU4_002112"
     CDS             1025..>2343
                     /gene="radA"
                     /locus_tag="AC0DU4_002112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003039163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003684 - damaged DNA binding [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HIN4238014.1"
                     /translation="MAKKKATFVCQNCGYNSPKYLGRCPNCGSWSSFVEEVEVAEVKN
                     ARVSLTGEKTKPMKLAEVTSINVNRTKTEMEEFNRVLGGGVVPGSLVLIGGDPGIGKS
                     TLLLQVSTQLSQVGTVLYVSGEESAQQIKLRAERLGDIDSEFYLYAETNMQSVRAEVE
                     RIQPDFLIIDSIQTIMSPEISGVQGSVSQVREVTAELMQLAKTNNIAIFIVGHVTKEG
                     TLAGPRMLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEIGIFEMQSGGLVEVLNP
                     SQVFLEERLDGATGSSIVVTMEGTRPILAEVQALVTPTMFGNAKRTTTGLDFNRASLI
                     MAVLEKRAGLLLQNQDAYLKSAGGVKLDEPAIDLAVAVAIASSYKDKPTNPQECFVGE
                     LGLTGEIRRVNRIEQRINEAAKLGFTKIYVPKNSLTGITLPKEIQVIG"
BASE COUNT          623 a          421 c          628 g          671 t
ORIGIN      
        1 taaataagat agaataatct agaataaatg ataatagaaa agagaaaatt atgaaaattc
       61 gtggttttga attggtttcg agttttacag atgaaaattt attgcccaag cgtgagacag
      121 cgcatgcggc tggttacgac ttaaaggttg ctgtgcgtac agttgttgcg ccaggagaga
      181 ttgtcttggt tccgacaggg gttaaggctt atatgcagcc gactgaggtt ctctacctct
      241 atgatcgttc ttcaaatcct cgtaagaagg gcttggtttt aattaactca gttggggtca
      301 ttgatgggga ttattatgga aatcctggaa atgaagggca tatttttgcg cagatgaaga
      361 atatcacaga tcaagaggtt gttcttgaag ttggggaacg tattgtccag gctgtttttg
      421 ctactttctt aattgcagat ggagatgcag ctgatggcgt tcgaactggt ggatttggat
      481 cgacagggca ctagaatgaa gattatcttt gtacgtcatg gggagccaga ttaccgtgag
      541 ttagaggagc gttcttatat aggatttggg atagatttgg cacccttgtc tgagatggga
      601 cggcagcaag tccagaaatt gagcaaaaat cctttactct cgtcagctga aataatcgta
      661 tcttctgcag tcacaagagc tttagaaacg gcttcgtatg tggtctgtgc tacgggtctt
      721 cctttaagag tagagccttt attacatgaa tggcaggtct ataaaacagg aatagaaaat
      781 tttgaaacag ctagaagact gtttttagaa aacaaggggg agttgcttcc taatagtcct
      841 attcaatatg agacagctac ggaaatgaag tctcggtttc tagaatgtat gtctaagtat
      901 cgagaacatc agactgtggt agttgttgct catcgaatgc tcatgcgcca gtttgtgcca
      961 aatgagaaga ttgatttttg ccaagtgatt gagtgtgagt tagagatata gaaagaggtt
     1021 tgtcatcgca aagaaaaaag cgacatttgt atgtcaaaat tgtgggtata attcccctaa
     1081 atatctggga cgttgcccca actgtgggtc ttggtcttct tttgtggaag aggttgaggt
     1141 tgccgaggtc aagaatgcgc gtgtgtcctt gacaggtgag aaaaccaagc ccatgaaact
     1201 agctgaggtg acttccatca atgtcaatcg aaccaagacg gagatggagg aattcaaccg
     1261 tgtgcttgga ggcggagtgg taccaggaag tctcgtcctc atcggtgggg atcctgggat
     1321 tgggaaatca actcttctcc tacaagtctc aacccagttg tcccaagtgg ggacagttct
     1381 ctatgtcagt ggggaggagt ctgcccagca gattaaacta cgtgcagagc gcttaggtga
     1441 tattgatagt gagttttatc tctatgcaga gaccaatatg cagagtgttc gtgcagaagt
     1501 ggagcgtatc cagccagact ttctcattat tgattccatc cagaccatca tgtctcctga
     1561 gatttcaggg gtgcaggggt ctgtttctca ggtgcgtgaa gtgaccgctg aactcatgca
     1621 gttggccaag accaataaca ttgccatctt tatcgtaggt catgtgacca aagaaggaac
     1681 cttggctggg cctcgtatgt tggagcatat ggtggatacg gtgctttact ttgaagggga
     1741 gcgtcaccac acctttcgta ttttgagagc ggtcaaaaat cgttttggtt ccactaatga
     1801 gattgggatt tttgagatgc agtcgggcgg cttggttgag gtactcaatc cgagtcaagt
     1861 tttcctagaa gagcgtttgg atggggcgac tggttcctcc atcgttgtaa ccatggaagg
     1921 gacgcgtccg attttggcgg aggttcaggc tttggtaaca ccgaccatgt ttggaaatgc
     1981 caagcgtact acgacaggac ttgattttaa ccgtgctagc ttgattatgg ctgttttgga
     2041 aaaacgggca gggcttctct tgcaaaatca ggatgcctat ctcaaatctg ctggtggtgt
     2101 taaattggat gaacctgcga ttgacttggc tgttgcagtt gctattgctt cgagctacaa
     2161 agacaagcca actaatcctc aggaatgttt tgtcggagaa ctgggcttga caggagagat
     2221 tcggcgcgtg aatcgtattg agcaacgcat caacgaagct gctaaactgg gctttactaa
     2281 gatttatgta cctaagaatt ccttgacagg aatcactctg cctaaggaaa ttcaggtcat
     2341 tgg
//
LOCUS       DBMVGT010000137         2124 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.137, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000137 DBMVGT010000000
VERSION     DBMVGT010000137.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2124)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.137"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1249
                     /gene="comD"
                     /locus_tag="AC0DU4_002113"
     CDS             <1..1249
                     /gene="comD"
                     /locus_tag="AC0DU4_002113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000362880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="competence system sensor histidine kinase ComD"
                     /protein_id="HIN4238015.1"
                     /translation="QINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIATFLFPLGL
                     YSYFRWIKQYERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVT
                     VLTYFVTLKIIYYFHLELAYFDKDYLYPFLKKVFFALLLLHIVSFVSDMVSTIKHLNS
                     FGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLYNEIR
                     GFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSAL
                     RSLVAQSIVYARNNGVEFTLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQ
                     MEVAVIKMETETVIVIQNSCKMTMTPSGDLFSLGFSTKGRNRGVGLNNVKELLDKYNN
                     IILETEMEGSTFRQIIRFKREFE"
     gene            1246..1998
                     /gene="comE"
                     /locus_tag="AC0DU4_002114"
     CDS             1246..1998
                     /gene="comE"
                     /locus_tag="AC0DU4_002114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence system response regulator
                     transcription factor ComE"
                     /protein_id="HIN4238016.1"
                     /translation="MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEE
                     YIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNPYAIIVFITSRSEFATLTYKYQV
                     SALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
                     IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRK
                     NLEIVFYEDHRCPISRLKIRKLKDILEKKSQK"
     gene            2050..2121
                     /locus_tag="AC0DU4_002115"
     tRNA            2050..2121
                     /locus_tag="AC0DU4_002115"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:2083..2085,aa:Glu,seq:ttc)
BASE COUNT          723 a          300 c          391 g          710 t
ORIGIN      
        1 tcaaataaat agaaaagaat tattcgtttt tggtgcttat acattactaa cagaaatagt
       61 atttgatttt cccttatata ttctatattt agatgggtta gggattgcaa catttttatt
      121 tcctttgggc ctatattcct attttcgatg gataaaacag tatgagaggg atagaggact
      181 attcctaagt ttactactat ctcttttata tgagagcact cataactttc tgtccgtaac
      241 tttctcctct ataacaggag ataattttgt tttacaatat catttcccat tctttttcgt
      301 tgtgacggtg ttaacctatt ttgttacatt aaaaatcatt tactatttcc atttggaact
      361 agcctatttt gacaaggact acctttatcc tttcttgaaa aaagtatttt ttgctttact
      421 attgctacat attgtatctt tcgtttcaga tatggtaagt acgattaaac atttgaatag
      481 ttttggaagt attttgtcat ctattgtctt tatctctctc cttttgacct tctttgcaat
      541 gaattctcat aaagttcaaa tggagaaaga gattgctttg aagcagaaga aatttgaaca
      601 gaaacattta cagaattaca cagatgaaat tgttggtctg tataatgaaa tccgtggttt
      661 tcgacatgat tatgctggaa tgcttgtcag catgcagatg gcaattgaca gtggtaattt
      721 acaggaaatt gacagaattt acaatgaagt tttagtcaaa gcaaatcata aattgcgttc
      781 agataagtac acttactttg atttgaacaa catagaagac tcagctttac gaagtttggt
      841 tgctcagtca attgtctatg ctcgaaataa tggtgtagag tttacactgg aagtaaaaga
      901 tacgattacc aagcttccaa ttgaactatt ggatttggtt cgtatcatga gcgttttatt
      961 gaataatgct gtcgaaggat cggctgatag ctataaaaag cagatggaag tagcagttat
     1021 taagatggaa actgaaacag ttattgtgat tcagaattca tgtaaaatga cgatgactcc
     1081 ttcaggagat ctattttcct taggattctc cactaaggga agaaatcgcg gagtcggatt
     1141 aaataatgtg aaagaactac tagataagta caacaatatt attttagaaa cagagatgga
     1201 aggcagtaca tttagacaaa tcattagatt taagagggaa tttgaatgaa agttttaatt
     1261 ttagaagatg ttattgaaca tcaagtgaga ctagagagaa tattggatga aatttcgaaa
     1321 gaatcgaata ttccaatatc atacaagaca acgggaaaag tccgtgaatt tgaagaatac
     1381 attgaaaatg atgaagtaaa tcagctttat ttcctagata tcgatattca tggaattgag
     1441 aaaaagggat ttgaagtggc tcagctcatt cgtcattaca atccttacgc tattatcgtc
     1501 tttatcacta gtcgatcaga gtttgcgact ctaacctata aataccaggt atcagcccta
     1561 gattttgttg ataaggatat caatgatgag atgtttaaga agagaattga gcaaaatatc
     1621 ttctacacga agagtatgtt acttgaaaat gaagatgttg tagattattt cgactacaat
     1681 tacaagggaa atgatttaaa aattccttac catgatattt tgtatattga aacaacaggg
     1741 gtatctcata aattgcgcat tattggtaag aattttgcaa aagagtttta tggtaccatg
     1801 acagatattc aggaaaagga caaacatact cagcgatttt attctcctca caagtcattt
     1861 ttggtaaata taggcaatat cagagaaatt gatcgaaaaa acttagaaat tgttttctat
     1921 gaagaccatc gttgtcctat ttcaagatta aaaattagaa aattaaaaga tattttagag
     1981 aaaaaatctc aaaagtgatt gacaattagc aagaaattga tataatggtt atatctgcta
     2041 cagatagaag gtccgttggt caaggggtta agacaccgcc ttttcacggc ggtaacacgg
     2101 gttcgaatcc cgtacggact attt
//
LOCUS       DBMVGT010000138         2107 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.138, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000138 DBMVGT010000000
VERSION     DBMVGT010000138.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2107)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.138"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..893)
                     /locus_tag="AC0DU4_002116"
     CDS             complement(<1..893)
                     /locus_tag="AC0DU4_002116"
                     /EC_number="2.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HIN4238017.1"
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQAISEIPGVLRLTLGEPDFTT
                     PDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATE
                     ALSATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAI
                     LEQGDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAH
                     VSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPATFTAQLIKSHQYLVTAANTMAQH
                     AAVEALTAGKNDAEPMKKEYI"
     gene            1042..2052
                     /locus_tag="AC0DU4_002117"
     CDS             1042..2052
                     /locus_tag="AC0DU4_002117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="YeiH family protein"
                     /protein_id="HIN4238018.1"
                     /translation="MSFLSKNGAGILVCLLISILSWYLGGFFPVIGAPVFAIFMGMLL
                     HPFLSSYKQLDVGLTFSSKKLLQYAVILLGFGLNISQVFAVGQSSLPVILSTISIALI
                     VAYLFQRFFALDTKLATLIGVGSSICGGSAIAATAPVIHAKEKEVAQAISVIFFFNVL
                     AALIFPTLGTWLHLSNDGFALFAGTAVNDTSSVTATASAWDSLYQTNTLESATIVKLT
                     RTLAIIPITLFLSYWQSREQKNKQGLQLKKVFPLFILYFILASLLTTLLTSLGVSSSF
                     FTPLKQLSKFLIIMAMSAIGLKTNLVAMVKSSGKSIVLGAVCWIAIILTSLGMQTLIG
                     IF"
BASE COUNT          517 a          576 c          385 g          629 t
ORIGIN      
        1 tggatatatt ccttcttcat gggctccgca tcgtttttac cagccgtcaa ggcttctacc
       61 gcagcatgtt gcgccatggt atttgcggca gtgaccaagt actggtgact cttgattaac
      121 tgggctgtga aggtcgcagg agcaaaaatc agccccaaac gccaacctgt catggcatgc
      181 gatttagaca aaccattgat aataatagcc tggtctctca acatcgttcc tagagacaca
      241 tgggcttcgc ccgtgtaggt caattctgag taaacctcat cacagacaac aaaaatttcg
      301 tacttgcgta aaacagctgc caaggcctct aactgctctc gactgtaggt aattcctgtc
      361 ggattggctg gatagttgag aataaccgcc ttgagcttat caccctgctc caaaatggcc
      421 ttctccaaca tctcaggagt caagacaaaa ccattttcag tcgtatcaat ctcaacaatt
      481 tctgccccaa ctagattgac gatcggttca taacccggat aagcaggagc tggcaagagc
      541 accttgtctc cctcttccaa aatagccgtc aaagtcgcag ataaagcctc tgtcgctccg
      601 atagtgacca agatttcatt ttcaggagca tagtccagtt ggtacttttc cttaacaaaa
      661 tcactggccg cctgacgtag agtcagcaga ccactcatcc ctgtatagta ggattggttc
      721 tgatcaatcg ctcgcttggc cgcctccttg acatggtctg gcgttgtaaa atcaggttcc
      781 cccaaggtca aacgcaagac cccaggaatc tccgaaatag cctggtcaaa ctgacgaatc
      841 aacgaaactt gaattttatc taactgttta ttaaagcgct tagttaagtc catagatacc
      901 tcctactttc aaaacgtatc tctattatac tacaaaagcc tcccgaccgc aaaaatacat
      961 tagagaatag ctttccactt tctattttac ttttcctgtt tacaggtcta taatggtaac
     1021 agattctatt tggaggtttt tatgtcattt ctatcaaaaa atggagcagg catcttggtc
     1081 tgccttctca tttccatcct atcttggtac ttaggaggat tcttccctgt tattggcgca
     1141 cccgtttttg cgatttttat gggcatgctc ctacatccct ttctctcgtc ttataaacaa
     1201 ctggatgttg gtttgacctt tagttccaag aaattgctcc agtatgccgt tatcttactt
     1261 ggttttggtc tcaatatctc tcaagtcttc gcagttgggc aatcttcact ccctgtcatc
     1321 ctttccacca tttcaatagc cttgattgtt gcctacctct tccagcgctt ctttgccctg
     1381 gatacaaaac tggctacctt gattggagta ggttcttcta tctgtggggg ttctgccatt
     1441 gcagcgacag cgcctgttat ccatgctaag gaaaaggaag tagcccaagc catctccgtt
     1501 atctttttct tcaatgtctt ggctgcgctc atctttccaa ccctcggcac ctggcttcat
     1561 ctatccaatg acggcttcgc cctctttgca ggaactgcgg tcaatgatac ttcctctgta
     1621 accgccacag ctagcgcttg ggacagtctc taccagacca ataccctcga atccgcaacc
     1681 attgtcaaac tcacgcgcac cctagctatc atccccatca ctctctttct ctcctactgg
     1741 caaagtcgcg agcaaaaaaa taagcaaggc ttacaactga aaaaagtctt cccacttttt
     1801 atcctttact tcatccttgc atcgctccta accacccttc tgacctctct cggtgtgtct
     1861 agtagtttct ttacccctct caaacaactc tctaaattcc tcattatcat ggccatgagt
     1921 gccatcggtc tcaaaactaa tctggtcgct atggtcaaat ccagtggaaa atccattgtt
     1981 ctcggagccg tctgctggat tgccatcatc ctcaccagcc ttggtatgca gacccttatc
     2041 ggcattttct aatactcttc gaaaatctct tcaaaccacg tcaacgtcgc cttgccgtat
     2101 atatgtt
//
LOCUS       DBMVGT010000139         2083 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.139, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000139 DBMVGT010000000
VERSION     DBMVGT010000139.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2083)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2083)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2083
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.139"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..656)
                     /locus_tag="AC0DU4_002118"
     CDS             complement(<1..656)
                     /locus_tag="AC0DU4_002118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003678 - DNA helicase activity [Evidence
                     IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="DnaB-like helicase N-terminal domain-containing
                     protein"
                     /protein_id="HIN4238019.1"
                     /translation="MAEVEELRVQPQDILAEQSVLGAIFIDESKLVFVREYIESRDFF
                     KYAHRLIFQAMVDLSDRGDAIDATTVRTILDNQGDLQNIGGLSYLVEIVNSVPTSANA
                     EYYAKIVAEKAMLRRLIAKLTESVNQAYEASQPADEIIAQAEKGLIDVSENANRSGFK
                     NIRDVLNLNFGNLEARSQQTTDITGIATGYRDLDHMTTGLHEEELIILAARPAVGKTA
                     "
     gene            complement(699..1151)
                     /gene="rplI"
                     /locus_tag="AC0DU4_002119"
     CDS             complement(699..1151)
                     /gene="rplI"
                     /locus_tag="AC0DU4_002119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HIN4238020.1"
                     /translation="MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATAQAV
                     GELRGKQKSEEKAHAEMIAEGKAIKAQLEAEETVVEFVEKVGPDGRTFGSITNKKIAE
                     ELQKQFGIKIDKRHIQVQAPIRAVGLIDVPVKIYQDITSVINLRVKEG"
     gene            complement(1148..>2083)
                     /locus_tag="AC0DU4_002120"
     CDS             complement(1148..>2083)
                     /locus_tag="AC0DU4_002120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HIN4238021.1"
                     /translation="NLDMDALGSAVGMQLFASNVIENSYALYDEEQMSPDIERAVSFI
                     EKEGVTKLLSVKDAMGMVTNRSLLILVDHSKTALTLSKEFYDLFTQIIVIDHHRRDQD
                     FPDNAVITYIESGASSASELVTELIQFQNSKKNRLSRMQASVLMAGMMLDTKNFTSRV
                     TSRTFDVASYLRTRGSDSIAIQEIAATDFEEYREVNELILQGCKLGSDVLIAEAKDTK
                     CYDTVVISKAADAMLAMSGIEASFVLAKNTQGFISISARSRSKLNVQRIMEELGGGGH
                     FNLAAAQIKDVTLSEAGEKLTEIVLNEIKEKEKEE"
BASE COUNT          597 a          493 c          316 g          677 t
ORIGIN      
        1 aatgctgtct taccaactgc tggacgagct gctaagataa tcaactcctc ctcatgaagt
       61 cctgttgtca tatgatccaa atcacgataa cctgtcgcaa tacctgtaat atcggtcgtt
      121 tgttgcgagc gagcttccag atttccaaag ttgagattca acacatctcg aatgttctta
      181 aacccgcttc gatttgcatt ttcactgaca tcaatcaacc ctttttctgc ctgagcaata
      241 atttcatcag ctggttgtga cgcttcgtaa gcttggttga cagactctgt caacttggca
      301 attaaacgac gtagcattgc tttttctgca acaatcttag cataatactc cgcattagca
      361 gaagttggca cagaattaac aatctcaacc aagtaagaca agccaccaat attctgtaaa
      421 tcaccttgat tatcaaggat agtacgaacc gttgttgcat ctatggcatc accacgatcg
      481 gataaatcga ccatggcttg gaaaatcaaa cgatgggcat acttaaaaaa gtcccgagac
      541 tcaatgtatt ctcgcacaaa aacaagttta ctctcatcaa taaagatagc ccctaaaacg
      601 gattgctcag ctaagatatc ttgaggttgt actcgtaact cttctacttc tgccatcaga
      661 cttcccttct tttacaatct tgtcaagaaa gtgtaaactt atccttcttt cacacgaaga
      721 ttgattacac ttgtgatatc ttgatagatt ttcactggca catcaatcaa accaaccgct
      781 cgaatcggag cttgtacttg aatatgacgt ttatcaatct taattccaaa ttgcttttgc
      841 aattcttctg caatcttctt attggtaata gaaccaaagg tacgaccatc tggaccaact
      901 ttttcaacaa attctacaac agtttcttct gcttcaagtt gtgctttaat tgcttttcct
      961 tctgcaatca tctcagcgtg agctttttct tccgattttt gtttaccacg aagttcacct
     1021 acagcttgag cagtcgcttc tttggctaga ttctttttga taagaaagtt ttgcgcatac
     1081 cctgttggta cttccttaat ttcgcctttt ttaccttttc ctttaacatc tgctaaaaag
     1141 attactttca ttcttctttc tccttttcct ttatttcatt taatacaatt tctgtcagtt
     1201 tttcacctgc ttctgacaag gttacatctt taatttgagc tgctgccaaa ttaaagtggc
     1261 ctccaccgcc taactcttcc ataatccgtt gtacattcag tttactacga cttcgagctg
     1321 agatagagat aaatccttgt gtattcttcg caagaacaaa actcgcttca atacctgaca
     1381 tggctaacat ggcatctgct gccttactaa taacaactgt atcatagcat ttcgtgtcct
     1441 tagcctctgc tattagtaca tctgaaccta atttacaccc ctgtaaaata agttcattga
     1501 cctcacgata ttcttcaaaa tctgtcgcag cgatttcctg gatagcaata ctatcacttc
     1561 cgcgcgttct gagatagcta gcaacatcaa atgtccgact agttactcgc gaggtgaaat
     1621 ttttagtatc caacatcata ccagccatca aaacacttgc ttgcatacga ctcaaacgat
     1681 ttttcttaga attctggaac tgaatcaatt ccgttaccaa ctcactggca ctacttgcac
     1741 cactttcgat ataagtaata accgcattat ctggaaaatc ctgatccctt ctatggtggt
     1801 caataacaat gatttgggta aataaatcat aaaattcttt tgataatgtt aaggctgtct
     1861 ttgaatggtc tacaagaatc aacaaagaac gattggtcac catccccatt gcatccttaa
     1921 cagacaacaa cttcgtaact ccttcttttt ctatgaatga aacagctcgt tcaatatctg
     1981 gagacatttg ttcttcatca taaagagcat agctattttc aatcacattg ctggcgaaca
     2041 actgcatacc tacagcagag cccaaagcat ccatgtctaa att
//
LOCUS       DBMVGT010000140         2069 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.140, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000140 DBMVGT010000000
VERSION     DBMVGT010000140.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2069)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2069)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2069
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.140"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..100
                     /locus_tag="AC0DU4_002121"
     CDS             <1..100
                     /locus_tag="AC0DU4_002121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HIN4238022.1"
                     /translation="PNEFVVGYGLDYKENYRNLPYIGVLKEEVYSN"
     gene            116..>2069
                     /gene="ftsH"
                     /locus_tag="AC0DU4_002122"
     CDS             116..>2069
                     /gene="ftsH"
                     /locus_tag="AC0DU4_002122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA];
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HIN4238023.1"
                     /translation="MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYT
                     ELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSKEGTGIQFFTPSVTKVEKFTSTI
                     LPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGG
                     GNGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGAR
                     IPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAK
                     KAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDGFEGNEGIIVIAATNR
                     SDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFV
                     GADLENVLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHE
                     AGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDMKEQLAGLMGGR
                     VAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEGNHAMFGAQNPQKS
                     ISEQTAYEIDEEVRSLLNKARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYE
                     TGKMPEAVEEESHALSYDEVKSKMNDE"
BASE COUNT          681 a          335 c          462 g          591 t
ORIGIN      
        1 cccaaatgag tttgtagtag gttatggttt agactacaaa gaaaattatc gtaatcttcc
       61 ttatattgga gtattgaaag aggaagtgta ttcaaattag aaagaataat ctttaatgaa
      121 aaaacaaaat aatggtttaa ttaaaaatcc ttttctatgg ttattattta tctttttcct
      181 tgtgacagga ttccagtatt tctattctgg gaataactca ggaggaagtc agcaaatcaa
      241 ctatactgag ttggtacaag aaattaccga tggtaatgta aaagaattaa cttaccaacc
      301 aaatggtagt gttatcgaag tttctggtgt ctataaaaat cctaaaacaa gtaaagaagg
      361 aacaggtatt cagtttttca cgccatctgt tactaaggta gagaaattta ccagcactat
      421 tcttcctgca gatactaccg tatcagaatt gcaaaaactt gctactgacc ataaagcaga
      481 agtaactgtt aagcatgaaa gttcaagtgg tatatggatt aatctactcg tatccattgt
      541 gccatttgga attctattct tcttcctatt ctctatgatg ggaaatatgg gaggaggcaa
      601 tggccgtaat ccaatgagtt ttggacgtag taaggctaaa gcagcaaata aagaagatat
      661 taaagtaaga ttttcagatg ttgctggagc tgaggaagaa aaacaagaac tagttgaagt
      721 tgttgagttc ttaaaagatc caaaacgatt cacaaaactt ggagcccgta ttccagcagg
      781 tgttcttttg gagggacctc cggggacagg taagactttg cttgctaagg cagtcgctgg
      841 agaagcaggt gttccattct ttagtatctc aggttctgac tttgtagaaa tgtttgtcgg
      901 agttggagct agtcgtgttc gctctctttt tgaggatgcc aaaaaagcag caccagctat
      961 catctttatc gatgaaattg atgctgttgg acgtcaacgt ggagttggtc tcggcggagg
     1021 taatgacgaa cgtgaacaaa ccttgaacca acttttgatt gagatggatg gttttgaggg
     1081 aaatgaaggg attatcgtca tcgctgcgac aaaccgttca gatgtacttg atcctgccct
     1141 tttgcgtcca ggacgttttg atagaaaagt attggttggc cgtcctgatg ttaaaggtcg
     1201 tgaagcaatc ttgaaagttc acgctaagaa caagccttta gcagaagatg ttgatttgaa
     1261 attagtggct caacaaactc caggctttgt tggtgctgat ttagagaatg tcttgaatga
     1321 agcagcttta gttgctgctc gtcgcaataa atcgataatt gatgcttcag atattgatga
     1381 agcagaagat agagttattg ctggaccttc taagaaagat aagacagttt cacaaaaaga
     1441 acgagaattg gttgcttacc atgaggcagg acataccatt gttggtctag tcttgtcgaa
     1501 tgctcgcgtt gtccataagg ttacaattgt accacgcggc cgtgcaggcg gatacatgat
     1561 tgcacttcct aaagaggatc aaatgcttct atctaaagaa gatatgaaag agcaattggc
     1621 tggcttaatg ggtggacgtg tagctgaaga aattatcttt aatgtccaaa ctacaggagc
     1681 ttcaaacgac tttgaacaag cgacacaaat ggcacgtgca atggttacag agtacggtat
     1741 gagtgaaaaa cttggcccag tacaatatga aggaaaccat gctatgtttg gtgcacagaa
     1801 tcctcaaaaa tcaatttcag aacaaacagc ttatgaaatt gatgaagagg ttcgttcatt
     1861 attaaataag gcacgaaata aagctgctga aattattcag tcaaatcgtg aaactcacaa
     1921 gttaattgca gaagcattat tgaaatacga aacattggat agtacacaaa ttaaagctct
     1981 ttacgaaaca ggaaagatgc ctgaagcagt agaagaggaa tctcatgcac tatcctatga
     2041 tgaagtaaag tcaaaaatga atgacgaaa
//
LOCUS       DBMVGT010000141         2054 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.141, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000141 DBMVGT010000000
VERSION     DBMVGT010000141.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2054)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.141"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..992)
                     /gene="tsaD"
                     /locus_tag="AC0DU4_002123"
     CDS             complement(<1..992)
                     /gene="tsaD"
                     /locus_tag="AC0DU4_002123"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HIN4238024.1"
                     /translation="MKDRYILAFETSCDETSVAVLKNDDELLSNVIASQIESHKRFGG
                     VVPEVASRHHVEVITACIEEALAEAGITEEDVTAVAVTYGPGLVGALLVGLSAAKAFA
                     WAHGLPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSEAGDYKIVGETR
                     DDAVGEAYDKVGRVMGLTYPAGREIDELAHQGQDIYDFPRAMIKEDNLEFSFSGLKSA
                     FINLHHNAEQKGESLSTEDLCASFQAAVLDILMAKTKKALEKYPVKTLVVAGGVAANK
                     GLRERLAAEVTDVKVIIPPLRLCGDNAGMIAYASVSEWNKENFANLDLNAKPSLA"
     gene            complement(982..1419)
                     /gene="rimI"
                     /locus_tag="AC0DU4_002124"
     CDS             complement(982..1419)
                     /gene="rimI"
                     /locus_tag="AC0DU4_002124"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008999 - protein-N-terminal-alanine
                     acetyltransferase activity [Evidence IEA];
                     GO_process: GO:0036211 - protein modification process
                     [Evidence IEA];
                     GO_process: GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HIN4238025.1"
                     /translation="MIEIKRIQQQPDLAKAIYAVMIAVYPVSPWTLEQIQADLFQDQT
                     WYALAYDGAEVIGFLAVQETLFEAEVLQIAVKGAYQGKGIASALFAQLPTDKEIFLEV
                     RQSNQRAQAFYKKEKMAVIAERKAYYHDPVEDAIIMKREIDEG"
     gene            complement(1416..2051)
                     /gene="tsaB"
                     /locus_tag="AC0DU4_002125"
     CDS             complement(1416..2051)
                     /gene="tsaB"
                     /locus_tag="AC0DU4_002125"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HIN4238026.1"
                     /translation="MLEDKQVLAETTINIKKNHSITLMPAIDFLMASLDWTPKDLDRI
                     VVAEGPGSYTGLRIAVATAKTLAHTLNIELVGMSSLLALVPRQQEGLVVPIMDARRNN
                     VYAGFYENAKPVMAEAHLSFEEVLEKVKGTSQVTFVGEVGPFVEQIQEYLPRTNFKET
                     LPNAANLALWAWDKEADSLHDFVPNYLKRVEAEENWLKNHTESGESYIKRL"
BASE COUNT          525 a          534 c          447 g          548 t
ORIGIN      
        1 gcgaggcttg gtttggcatt gaggtccaag tttgcaaagt tttctttgtt ccactcgctg
       61 acactggcat aagcaatcat acctgcattg tctccgcaga ggcgcagagg tggaatgatg
      121 accttgacat ctgtaacctc ggctgctagg cgttctctga gacctttatt ggctgccaca
      181 ccacctgcca caaccagggt tttaacagga tatttctcca aagccttctt ggtttttgcc
      241 atgagaatat ccagtacagc tgcttggaag gaagcacaca aatcctctgt agacagactt
      301 tctccctttt gctcggcatt gtggtgaaga ttgataaagg cagatttcaa accagagaat
      361 gaaaactcca gattatcttc cttaatcata gcacgaggga aatcataaat atcctgcccc
      421 tgatgagcca gctcgtcaat ctcacgacct gcaggatagg tcaagcccat gacacgaccg
      481 accttgtcat aagcctcccc aactgcatcg tctcgtgtct ctccaacaat cttgtaatcg
      541 ccagcctcag aaacatagac caactctgtg tgcccaccac tgactaaaag ggctagcaag
      601 ggaaactcca aaggctccac actctgagct gccatgaggt gcccagccat gtgattaaca
      661 ggaatcagtg gaagtccgtg agcccaagca aaggccttgg cggctgacaa accaactagc
      721 aaggctccga ccaagcctgg tccgtaggta accgcaacag ctgtcacgtc ctcttcggta
      781 atccctgctt ctgccaatgc ctcctcgata caggctgtaa tgacctcgac atggtgacga
      841 ctggctactt cgggcactac gccaccaaaa cgtttgtgac tctcaatttg actagcaatg
      901 acattggaca agagctcatc gtcgtttttc aagacggcga cactggtctc atcacaggat
      961 gtctcaaatg ctaaaatata tctatccttc atctatttct ctcttcatga taatggcgtc
     1021 ctcgactggg tcatggtagt aggcctttcg ctcagcgata actgccatct tttctttctt
     1081 gtaaaatgct tgcgctcgtt gatttgactg tctgacttcg aggaaaattt ccttgtctgt
     1141 cggcaattga gcaaacaagg ctgacgcaat gcccttaccc tgataggctc ctttgacagc
     1201 gatttgcagg acttctgctt caaagagagt ctcctgaaca gctagaaagc caatcacttc
     1261 tgccccatca taagccagag cataccaagt ctggtcttgg aacaggtcag cttggatttg
     1321 ttccagcgtc caaggactga ctgggtaaac agctatcata acagcgtaga tggctttagc
     1381 tagatcaggc tgctgttgga ttcgtttgat ttctatcata ggcgtttaat gtaagactcg
     1441 ccagactcgg tatggttctt gagccagttt tcctcagcct cgacacgctt gaggtaattt
     1501 ggcacaaagt cgtgcaagga gtctgcttct ttgtcccagg cccaaagagc tagattagct
     1561 gcatttggca aggtttcttt gaaattagtc cttggcaagt attcttgaat ctgctcaaca
     1621 aaggggccaa cttctccgac aaaggttacc tgactagtac ccttgacttt ttctagcacc
     1681 tcttcaaaag ataggtgcgc ttctgccatg acaggtttgg cattttcata aaagcctgca
     1741 tagacattgt tgcgacgcgc atccatgata ggaaccacca agccttcttg ttggcgtggc
     1801 accagagcca atagactaga catcccaact aactcaatgt tcagggtatg agccaaggtc
     1861 ttggcagttg ctaccgcaat tcgcaagcct gtatagctac ccggcccttc agctaccacg
     1921 attcggtcca aatccttggg tgtccaatcc aaacttgcca tcaaaaaatc gatggcaggc
     1981 ataagggtaa tactgtgatt tttcttaata ttaatcgtcg tctcggcaag aacctgctta
     2041 tcctctaaaa taac
//
LOCUS       DBMVGT010000142         1990 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.142, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000142 DBMVGT010000000
VERSION     DBMVGT010000142.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1990)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.142"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..842)
                     /locus_tag="AC0DU4_002126"
     CDS             complement(<1..842)
                     /locus_tag="AC0DU4_002126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000803403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase domain-containing protein"
                     /protein_id="HIN4238027.1"
                     /translation="MKPLLETIDTRFGTASKHAFSRGNTLPYTGVPFGMNYFVPQTSD
                     QDGSWFFDPHLPIFQGIRLTHQPSPWIGDYSWLLLTPVTSQLGGDSLFHRQSSYDIDK
                     ACFQPHYLKLFSLRYQIETQLTPTCYGASIRLKQKQGKALSLYLHAADELTVEQVDKR
                     TLALRQEGKTETNKNPLMLFTALQMNTDILAISQEAGDWRIDLASSQTEMQLATSFIS
                     PSQALLNLPQEDFDSCKSSAQADWENLLHRFDIIEIGEADRTFFDHCLYRLFLFPQTF
                     YEIN"
     gene            1014..>1990
                     /locus_tag="AC0DU4_002127"
     CDS             1014..>1990
                     /locus_tag="AC0DU4_002127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 125 protein"
                     /protein_id="HIN4238028.1"
                     /translation="MVYSKEIVREWLDEVAERAKDHPEWVDVFERCYTDTLDNTVEIL
                     EDGSTFVLTGDIPAMWLRDSTAQLRPYLHVAKRDALLRQTIAGLVKRQMTLVLKDPYA
                     NSFNIEENWKGHHETDHTDLNGWIWERKYEVDSLCYPLQLAYLLWKETGETSQFDEIF
                     VAATKEILHLWTVEQDHKNSPYRFVRDTDRKEDTLVNDGFGPDFAVTGMTWSAFRPSD
                     DCCQYSYLIPSNMFAVVVLGYVQEIFAALNLADSQSVIADAKRLQDEIQEGIENYAYT
                     INSKGEKIYAFEVDGLGNASIMDDPNVPSLLAAPYLGYCSVDDEVYQATR"
BASE COUNT          554 a          391 c          497 g          548 t
ORIGIN      
        1 tcattaatct cataaaaagt ctgtgggaag aggaagagtc tgtagaggca gtggtcaaag
       61 aaggttcggt cagcctctcc tatctctata atgtcaaaac gatggaggag attttcccaa
      121 tccgcttggg cacttgattt acagctatca aaatcttctt gaggtagatt aagcagtgct
      181 tgagaaggag agatgaaaga agtggctagt tgcatctcgg tttgactact tgctaagtca
      241 attcgccagt ctccagcttc ttggctgata gcaagaatat ccgtgttcat ttgcagggca
      301 gtgaagagca tcagtggatt tttattggtc tctgttttgc cttcttgtct gagagccaga
      361 gtccgcttat ctacctgctc aactgttagt tcatctgctg cgtgaagata gagggagagg
      421 gctttgcctt gcttttgctt caaacgaata gaagcaccat agcaagtcgg tgtgagctgg
      481 gtttcaattt gatagcgcag ggaaaagagc ttcaaatagt gaggctggaa gcaagcttta
      541 tctatatcat aagaagactg gcggtgaaag aggctgtctc cacccagttg actggtgaca
      601 ggtgtcagaa ggagccaaga gtagtcccca atccaaggac tgggctggtg agttaatcga
      661 atcccctgaa agataggcag atgcggatca aaaaaccaag atccatcctg gtcactggtc
      721 tggggcacaa aataattcat cccaaaaggc acgcctgtgt atggcagggt atttccccga
      781 gagaaggcat gcttgctagc agtaccaaag cgggtatcga tggtttcaag tagtggtttc
      841 atagtctttc ctttagctgt ttttctacat tatatcagaa aaagagggcc tttagaaaag
      901 gagttttaaa gataactatt ttgtagaaaa atgactatca tttgtgtatg tattttctgt
      961 ctcaaaagct atatactgaa aatgaaactt gtttgaaaga ggtaaaattt aaaatggttt
     1021 attcgaaaga aattgttaga gaatggctag atgaagtagc agagcgggcc aaggaccatc
     1081 cagagtgggt ggatgtcttt gagcgttgct acaccgatac cttggacaat acggttgaaa
     1141 tcttagaaga tggttcaact tttgtcttga ctggggatat tcctgccatg tggcttcgag
     1201 attcgacagc ccaactcaga ccctaccttc atgtagctaa aagagatgcc ctcctgcgtc
     1261 agaccattgc aggtttggtc aaacgtcaga tgaccttggt actcaaggat ccctatgcta
     1321 actccttcaa cattgaggag aactggaaag ggcaccacga gactgaccac acagacctta
     1381 acggctggat ctgggagcgc aagtatgagg tggattcgct ttgctatcct ttgcagttgg
     1441 cttatctcct ctggaaagag actggcgaga ctagtcagtt tgatgagatt tttgtcgcag
     1501 cgactaagga aattctccat ctatggacag ttgaacaaga ccacaagaac tctccttatc
     1561 gttttgtccg agatacggac cgtaaggaag ataccttggt aaatgatggc tttggacctg
     1621 actttgcagt gacaggtatg acttggtcag cctttcgtcc gagtgatgac tgttgccagt
     1681 atagttactt gattccgtca aatatgtttg ctgtagtagt cttgggttat gtgcaagaaa
     1741 tcttcgcagc attaaaccta gctgatagcc agagtgttat tgctgatgcc aagcgtcttc
     1801 aggatgaaat ccaagaagga atcgaaaact acgcttacac catcaacagc aagggcgaaa
     1861 agatttacgc ttttgaagtg gatggcctag gaaatgccag catcatggat gatccaaatg
     1921 taccaagtct actagctgcg ccctatctgg gctactgttc ggtcgatgat gaagtgtatc
     1981 aagctactcg
//
LOCUS       DBMVGT010000143         1971 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.143, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000143 DBMVGT010000000
VERSION     DBMVGT010000143.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1971)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.143"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..206
                     /locus_tag="AC0DU4_002128"
     CDS             <1..206
                     /locus_tag="AC0DU4_002128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="competence protein ComB"
                     /protein_id="HIN4238029.1"
                     /translation="FLDSTITSIDATATKTEKGNFFKIEAETNLTSEQAEKLRYGVEG
                     RLQMITGKKSYLRYYLDQFLNKE"
     gene            376..1083
                     /gene="purC"
                     /locus_tag="AC0DU4_002129"
     CDS             376..1083
                     /gene="purC"
                     /locus_tag="AC0DU4_002129"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002312208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004639 -
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase
                     activity [Evidence IEA];
                     GO_process: GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HIN4238030.1"
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIVG
                     KGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSK
                     RFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIAGDQQIAYLKEETRRINEL
                     LKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLG
                     ELTDVYEIVWEKLQELK"
     gene            1085..1228
                     /locus_tag="AC0DU4_002130"
     CDS             1085..1228
                     /locus_tag="AC0DU4_002130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015605805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HIN4238031.1"
                     /translation="MFATENLRLSTKRTQAEKVPQTFSLCRELGELTDVYEIVWEKLQ
                     GLK"
     gene            1285..>1971
                     /locus_tag="AC0DU4_002131"
     CDS             1285..>1971
                     /locus_tag="AC0DU4_002131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HIN4238032.1"
                     /translation="MDKRIFVEKKADFQVKSESLVRELQHNLGLSSLKSIRIVQVYDV
                     FDLAEDLFAPAEKHIFSEQGTDHVLDEVSVQADLANYAFFAIESLPGQFDQRAASSQE
                     ALLLLGSSSDVTVNTAQLYLVNKDIDATELEAVKNYLLNPVDSRFKDITTGIAKQEFS
                     ESDKTIPKLTFFESYTAEDFARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVL
                     DTYWSDHCRHT"
BASE COUNT          589 a          331 c          464 g          587 t
ORIGIN      
        1 tttttctaga ttctactatt acaagtattg atgcgacagc tactaagact gagaaaggga
       61 atttctttaa aatcgaggcg gagactaatc taacttcgga gcaggctgaa aaacttaggt
      121 acggggtgga aggccgtcta cagatgatta cgggcaagaa aagttatcta cgttattatt
      181 tggatcaatt tttgaacaaa gagtaatgtt cgtgttttta gagttaaata atttttaaac
      241 tgtgagaaag attcttcttg cagttttttc tttacaattt ttgaaaaaca tatgctattt
      301 attcggttaa attcttgtgt tttttggttt tttgtggtaa aatgtgctca agtaatacga
      361 aaggcgaact ttaaaatgtc aaaacaattg atctattcgg gaaaagctaa agatatctat
      421 acaactgagg atgaaaatct tattatttca acttacaagg accaggcgac tgctttcaac
      481 ggtgtcaaga aggagcagat tgtaggtaag ggagtcttga ataatcagat ctcatctttt
      541 atttttgaga aattaaatgc ggctggtgtg gcgactcact ttgtggagaa actttcagac
      601 acggaacaac tcaataaaaa ggttaagatt attcctttgg aagtcgtgct ccgcaactat
      661 actgctggtt ccttttcaaa acgttttggt gtggatgagg gaatcgcctt ggagactccg
      721 attgtcgaat tttactacaa aaatgatgat ttggatgatc catttatcaa tgatgagcat
      781 gtgaaattcc tacagattgc gggtgaccag cagattgcct acttgaagga agaaacgcgt
      841 cgtatcaatg aactattgaa agtctggttt gctgagattg ggcttaaatt gattgacttt
      901 aagctagagt tcggttttga caaggatggc aagattatct tggcagacga attttcacca
      961 gataactgcc gcttgtggga cgctgatggc aaccacatgg ataaggatgt tttccgtaga
     1021 ggattgggag aactaaccga cgtttatgag attgtttggg aaaagttgca ggaattgaaa
     1081 taatctgttt gcaacggaaa accttcgtct ctcaactaaa aggactcagg ctgaaaaggt
     1141 cccccagacc ttttcactct gtagagaact aggtgaacta acagatgttt acgaaattgt
     1201 ctgggaaaag ttgcagggtt taaaataaca acctcaaggc tgtttgggaa tattgcaaga
     1261 gctgaaataa aggaataaga attgatggat aaacgtattt ttgttgaaaa aaaggctgat
     1321 tttcaggtca agtcagagag tttggttaga gagctccagc acaacttggg actgtcaagc
     1381 ttgaaaagta ttcgtattgt gcaagtatat gatgtatttg acttggctga ggacttgttt
     1441 gcacctgcag agaagcacat tttctctgag cagggaaccg accatgtttt agatgaagta
     1501 tctgtgcagg cggatcttgc taactatgct ttctttgcca ttgaaagtct gccagggcag
     1561 tttgaccagc gtgcagcttc gtcacaggaa gccttgcttt tgttgggaag ttcgagtgac
     1621 gtgacagtca acacagccca actttacttg gtgaataaag atattgatgc gactgagttg
     1681 gaagctgtca aaaactacct gctcaatcca gttgattctc gtttcaagga tatcacgaca
     1741 gggattgcca agcaggagtt ttcagagtca gacaagacca ttccaaaatt gactttcttt
     1801 gaaagctata cagcagaaga ctttgctcgc tacaaggccg agcaagggat ggccatggaa
     1861 gtggatgatt tgctctttat ccaagactac tttaagtcaa tcgggcgcgt gccaactgag
     1921 actgaactca aggttttgga cacttactgg tctgaccact gccgtcatac g
//
LOCUS       DBMVGT010000144         1890 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.144, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000144 DBMVGT010000000
VERSION     DBMVGT010000144.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1890)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.144"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..346
                     /locus_tag="AC0DU4_002132"
     CDS             <1..346
                     /locus_tag="AC0DU4_002132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="DNA-binding response regulator"
                     /protein_id="HIN4238033.1"
                     /translation="AGYFERAVKAGVDAYVLKERSIADLMQTLHTVLEGRKEYSPELM
                     EVVMTRPNPLTEQEIAVLKGIARGLSNQEIADQLYLSNGTIRNYVTNILSKLDAGNRT
                     EAANIAKESGWL"
     gene            771..1781
                     /gene="ccpA"
                     /locus_tag="AC0DU4_002133"
     CDS             771..1781
                     /gene="ccpA"
                     /locus_tag="AC0DU4_002133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000990602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0001228 - DNA-binding transcription
                     activator activity, RNA polymerase II-specific [Evidence
                     IEA];
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="catabolite control protein A"
                     /protein_id="HIN4238034.1"
                     /translation="MNADDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEV
                     IDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFSSLAKGIDDIAEMYKYNIVLANS
                     DEDNEKEVSVVNTLFSKQVDGIIYMGYHLTDKIRSEFSRSRTPIVLAGTVDVEHQLPS
                     VNIDYKQATIDAVSYLAKENERIAFVSGPLVDDINGKVRLVGYKETLKKAGITYSEGL
                     VFESKYSYDDGYALAERLISSNATAAVVTGDELAAGVLNGLADKGVSVPEDFEIITSD
                     DSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREVLLPHGLTERSSTRK
                     RK"
BASE COUNT          590 a          322 c          429 g          549 t
ORIGIN      
        1 tgctgggtat tttgaacgtg cggtcaaggc tggagtggat gcttatgtat taaaggaacg
       61 aagcattgca gacctcatgc aaaccttgca caccgtcctc gaaggacgca aggagtattc
      121 gcctgaattg atggaagtgg tgatgacccg tcccaatccg ttgacagaac aagagattgc
      181 tgtcttaaag ggaatcgccc ggggcttatc caaccaagaa atcgcagatc agctttacct
      241 ctcaaacgga actattcgaa actatgtcac caatattctt tcaaaactgg atgctggtaa
      301 tcgaacagag gcagctaata tcgcaaaaga atctggttgg ttatgatgat ataatatttt
      361 catgaagact atgtgctaaa attgacggta gtgaatggaa caatacctat agtagatgga
      421 aactagaata gtacacctct acttctaaaa cattgttaga aatcgatttg actgtcctga
      481 tcgatttatc ctgttcttat ttcattttac tataacttta ggagggctta gtttcctcct
      541 ttttgtttag tctaaggtgg tagcaaggag ctaaacctag gttttctatg aaattttttc
      601 aatcaatctt caaaaaacac ttgaaagtgt ttacaattag tgatagaatg gaataagtag
      661 aaatatgaaa acgaaatttt cacatcttca cttttgtaag tagatataga gcttcaatca
      721 gtacctctac ttgtaaaaga atgtgtgaga tagaaaggac aggaaaagga atgaatgcag
      781 atgatacagt aaccatttat gatgtcgctc gtgaagcagg tgtttccatg gcgacggtca
      841 gccgtgtggt caatggcaat aaaaatgtaa aagagaatac ccgtaaaaaa gtgctagagg
      901 taattgatcg tttggattat cgtccaaatg cagttgcgcg tggtcttgca agtaaaaaga
      961 caaccactgt cggtgtcgtg attccaaata ttaccaatgg ttatttttcg agtttggcta
     1021 aggggattga tgatattgca gaaatgtaca agtacaatat tgtcctagct aatagcgatg
     1081 aagataacga gaaagaagtt tctgttgtca ataccctctt ttcaaagcag gtagatggca
     1141 ttatctatat gggttatcac ttgacagata aaattcgctc agaattttcg cgttcacgta
     1201 ctccgattgt tctcgcagga actgtcgatg ttgagcacca gttgccaagt gtcaatattg
     1261 actataagca agcaacaatt gatgcagtga gttaccttgc taaagaaaat gagcgtattg
     1321 ctttcgttag cggtccgcta gtggatgaca tcaatggtaa ggttcgttta gttggctaca
     1381 aggaaacctt gaaaaaagca ggaatcactt atagtgaggg tttggtattt gaatctaaat
     1441 atagctatga tgatggttac gccttagcag agcgtttgat ttcatcaaat gcaactgcag
     1501 cagttgtgac aggtgatgag ttggcagcag gagtcttgaa cggtttggct gataagggtg
     1561 tttctgtgcc agaagatttt gaaattatta ctagtgatga ttcacaaatc tcacgcttta
     1621 cccgtccaaa cttgacaacg attgcccaac ctctttatga ccttggtgcc attagtatgc
     1681 gtatgttgac caagattatg cataaggaag agttggaaga acgtgaagtt ctcttacctc
     1741 atggtttgac agaacgtagc tcaacacgaa aacgtaaata gaaaaaatca gggaatcgag
     1801 aagatttcct gattttgtgc tcttaaacaa gagatgttga cttaatgaat accatagagc
     1861 ggactaggcg gctggttaaa ggctgcgcaa
//
LOCUS       DBMVGT010000145         1840 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.145, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000145 DBMVGT010000000
VERSION     DBMVGT010000145.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1840)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.145"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(47..481)
                     /locus_tag="AC0DU4_002134"
     CDS             complement(47..481)
                     /locus_tag="AC0DU4_002134"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004126 - cytidine deaminase activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0009972 - cytidine deamination [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase family protein"
                     /protein_id="HIN4238035.1"
                     /translation="MDIWEKMYEEAQKLYNPHEVSDFVYANHVVAAVEAEDGQIFTGF
                     CMEGTCGVFHLCAERAALFNMYQFSGQTKVKKVLAFRDKPPYGGSSAMPCGACREFLL
                     ELNAENKDAEFMMDYNIRKTVKVAELIPYWWGEERASKFNER"
     gene            complement(495..>1840)
                     /gene="gltX"
                     /locus_tag="AC0DU4_002135"
     CDS             complement(495..>1840)
                     /gene="gltX"
                     /locus_tag="AC0DU4_002135"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000166 - nucleotide binding [Evidence
                     IEA];
                     GO_function: GO:0004818 - glutamate-tRNA ligase activity
                     [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HIN4238036.1"
                     /translation="LIRIEDTDRKRHVEDGERSQLENLRWLGMDWDESPESHENYRQS
                     ERLDLYQKYIDQLLAEGKAYKSYVTEEELAAERERQEVAGETPRYINEYLGMSEEEKA
                     AYIAEREAAGIIPTVRLAVNESGIYKWHDMVKGDIEFEGGNIGGDWIIQKKDGYPTYN
                     FAVAIDDHDMQISHVIRGDDHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLS
                     KRDTNTLQFIEDYRKKGYLPEAVFNFIALLGWNPGGEDEIFSREELIKLFDENRLSKS
                     PAAFDQKKLDWMSNDYIKNADLETIFEMAKPFLEEAGRLTDKAEKLVELYKPQMKSVD
                     EIIPLTDLFFSDFPELTEAEREVMTGETVPTVLEAFKAKLEAMTDDKFVTENIFPQIK
                     AVQKETGIKGKNLFMPIRIAVSGEMHGPELPDTIFLLGREKSIQHIENMLKEISK"
BASE COUNT          479 a          395 c          341 g          625 t
ORIGIN      
        1 attttttcaa cttatagtaa aaaaagccag aattatactg actcttctat cgctcattaa
       61 acttagaagc acgttcttct ccccaccaat aagggattag ttctgcgact ttaactgttt
      121 ttcttatatt atagtccatc atgaattctg catctttatt ttcagcatta agctctaaaa
      181 ggaattctct acaagcaccg caaggcatgg ctgaacttcc accataaggt ggtttgtctc
      241 gaaaggctaa tactttctta accttagttt gtcctgaaaa ttggtacata ttgaagaggg
      301 ccgcccgttc tgcgcagaga tggaaaacac cacaggttcc ctccatacag aatcctgtaa
      361 atatttgtcc atcttctgct tctactgcag ctacaacatg attggcataa acaaagtctg
      421 atacttcatg tggattgtat agtttctgtg cttcttcgta catcttttcc cagatgtcca
      481 ttattgtatc ctctttattt agagatttct tttagcatgt tttcgatatg ctgaattgat
      541 ttttcacgtc caagcaagaa aattgtatct ggtaattctg gcccatgcat ttcgcctgaa
      601 actgcgatac gaataggcat gaaaagattt ttccctttaa tacctgtttc tttttgaact
      661 gctttaattt gtgggaagat attttctgtc acaaatttat catctgtcat cgcttcaagt
      721 tttgctttga atgcttcaag aactgttgga actgtttcac ccgtcatgac ttcgcgctct
      781 gcttctgtca attctgggaa atctgagaag aaaagatctg tcaatgggat aatctcatct
      841 actgatttca tttgtggttt atagagctca actaattttt cagccttgtc agtcaaacgg
      901 cctgcttcct ctaagaatgg ttttgccatt tcaaagatgg tttcaaggtc tgcattcttg
      961 atataatcat tgctcatcca gtctagtttt ttctgatcaa aggctgctgg tgacttgctg
     1021 aggcggtttt catcaaaaag tttaatgagt tcttcacgag agaaaatctc atcttcacca
     1081 cctgggttcc aaccaagaag agcaataaag ttaaagactg cttctggaag gtaacctttc
     1141 tttcggtaat cttcgataaa ttgaagtgta ttagtatcac gtttagataa cttcttacca
     1201 gtctcagagt tgataatcaa ggtcatgtga ccaaactctg gagcttccca accaagtgct
     1261 tcataaacca tgagctgttt tggtgtgtta gcaatatggt cgtctccacg gataacatga
     1321 gagatttgca tatcatggtc atcgatggca acggcaaagt tgtaagttgg gtaaccgtct
     1381 ttcttttgga taatccagtc accaccgata ttgccacctt caaattcgat atcgcctttg
     1441 accatatcat gccacttgta gatacctgac tcattgacag ccaaacgaac agttgggatg
     1501 atccctgctg cttcacgttc tgcgatgtaa gctgcttttt cttcttcact cataccaagg
     1561 tattcattga tgtagcgtgg tgtttcgcca gctacttctt ggcgttcgcg ttcagctgcc
     1621 aactcttctt ctgtaacgta agatttatag gcttttcctt cagctaatag ttggtcaatg
     1681 tatttttgat acaagtccaa acgctcagac tggcgataat tctcatgtga ttctggactt
     1741 tcatcccaat ccatgcctaa ccagcgaagg ttttcaagtt gtgaacgttc accatcctcg
     1801 acatggcgtt tacggtcagt atcttcgata cggatgagaa
//
LOCUS       DBMVGT010000146         1823 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.146, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000146 DBMVGT010000000
VERSION     DBMVGT010000146.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1823)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1823)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1823
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.146"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..1608)
                     /locus_tag="AC0DU4_002136"
     CDS             complement(<1..1608)
                     /locus_tag="AC0DU4_002136"
                     /EC_number="2.7.1.211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose-specific PTS transporter subunit IIBC"
                     /protein_id="HIN4238037.1"
                     /translation="MDYSKVAAEVIEAVGKDNLVAAAHCATRLRLVLKDEAKVNQAAL
                     DNNADVKGTFSTNGQYQIIIGPGDVNFVYAEIIKKTGLKEVSTDDLKEIANKDKKFNP
                     LMDLIKLLSDIFVPIIPALVAGGLLMALRNFLTSPDLFGPQSIEDMYPAIKGFSAMIQ
                     LMSAAPFMFLPVLVGISAAKRFGANQFLGAAIGMIMTTPDLGGKEAFWDILGFHVTQT
                     NYAYQVIPVLVAVWLLANLEKFFHKKLPSAVDFTFTPLLSVMITGFLTFTVIGPVMLV
                     VSDAITNAIVWLYNTTGAFGMGLFGGTYSLIVMTGLHQSFPAIETQLLSAYNNNGTGF
                     GDYIFVVASMANVAQGAATLAVYFLTKNAKTKGLSSSAAVSAFLGITEPALFGVNLKY
                     KFPFFCALAGSAIGAFVAGLTHVIAVSLGAAGFIGFLSIKAGSIPMYIIAEIMSFVAA
                     FAFTYFYGKTKAASVFADEAATATAETVTEPTVEAPVVEETDTLQNETLVTPIVGDVV
                     ALADVNDPVFSSGAMGQGIAVKPSQGVV"
BASE COUNT          583 a          379 c          352 g          509 t
ORIGIN      
        1 gaccacgcct tggcttggtt tcacagcgat accttgtccc atagctccac ttgagaagac
       61 tgggtcattg acatcagcaa gagcgacaac atcaccaacg ataggagtta caagtgtttc
      121 attttgaaga gtatcagtct cttccactac tggtgcttct actgtaggtt ctgtaactgt
      181 ttctgcggtt gctgtggcag cttcatcagc aaagacacta gctgcttttg ttttcccgta
      241 gaaataagtg aaagcaaagg cggcaacaaa ggacataatt tccgcaatta tatacatagg
      301 gattgaacca gccttaatag aaaggaatcc aataaatcca gccgctccca atgaaactgc
      361 aataacgtga gttaaacctg ctacaaaggc accaattgct gaaccagcaa gggcgcagaa
      421 gaatgggaat ttgtatttca agtttacccc aaagagagca ggttctgtaa taccaaggaa
      481 ggcagaaaca gcagccgaac tggacaatcc ttttgtttta gcattttttg tcaagaagta
      541 gactgcaaga gtagccgcac cttgtgctac gtttgccatt gaagcaacaa caaagatgta
      601 gtctccaaat ccagtaccgt tattattgta tgcagacaac aattgtgttt cgattgctgg
      661 gaatgattgg tgaagacccg tcataacgat taatgagtaa gttccaccaa atagccccat
      721 accaaaggca cctgttgtgt tgtacaacca tacaatcgca tttgtaatcg catcagacac
      781 aaccaacata acaggaccga taactgtaaa ggtaaggaat cctgtaatca tcactgataa
      841 aagcggtgta aaagtgaagt caactgcaga tggcaatttc ttgtggaaga atttttctaa
      901 attagctaac aaccagactg caacaaggac tggaataacc tgataagcat agtttgtttg
      961 tgtaacatgg aaacctaaga tgtcccagaa ggcttcttta ccacccaaat ctggagtggt
     1021 cataatcata ccgattgccg caccaaggaa ttggtttgct ccaaagcgct tggctgctga
     1081 aataccaacc aaaacaggga ggaacataaa tggagcagca gacatcaatt gaatcatagc
     1141 tgagaagcct ttgatagcag gatacatatc ttcaattgat tgaggtccaa acaaatctgg
     1201 tgatgtcaag aagttccgta aagccatcaa gagaccacct gcaactaagg cagggataat
     1261 aggaacaaaa atgtctgaca aaagtttaat caagtccatc aatggattga actttttgtc
     1321 tttattagca atctctttca aatcatctgt cgaaacttct ttcaaaccag ttttcttaat
     1381 aatttccgca tatacgaagt taacatcacc aggaccaatg ataatttgat attgtccgtt
     1441 agtgctaaaa gtccccttga catccgcatt attatccaga gctgcttgat tcacttttgc
     1501 ttcgtctttc aataccaagc gaagacgtgt cgcacagtga gctgcagcta caagattatc
     1561 cttaccgaca gcctcaatga cctcggcagc aactttacta taatccatag caaaaatctc
     1621 cttatataac attttgttct tgtttgaaag cgattttatt cgcccttacg actattattt
     1681 tatcatgttt taaaaatatg tcaagcgttt tgcagaaaaa atattctatc tacttagtgg
     1741 gcaagcttta gattgattgt ttttgactgt ttcatcagga attccttgaa aaataagttt
     1801 gaaaccttgg ttaaaaagtc ttt
//
LOCUS       DBMVGT010000147         1696 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.147, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000147 DBMVGT010000000
VERSION     DBMVGT010000147.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1696)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.147"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            20..1336
                     /locus_tag="AC0DU4_002137"
     CDS             20..1336
                     /locus_tag="AC0DU4_002137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000958936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016668 - oxidoreductase activity, acting
                     on a sulfur group of donors, NAD(P) as acceptor [Evidence
                     IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-containing oxidoreductase"
                     /protein_id="HIN4238038.1"
                     /translation="MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCI
                     NIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNGKNYTTVAGTGVDIFDAEAHFLS
                     NKVIEIQAGDEKQELTAETIVINTGAVSNVLPIPGLATSKNVFDSTGIQSLDKLPEKL
                     GVLGGGNIGLEFAGLYNKLGSKVTVLDALDTFLPRAEPSIAALAKQYLEEDGIELLQN
                     IHTTEIKNDGDQVLVVTEDETYRFDALLYATGRKPNVEPLQLENTDIELTERGAIKVD
                     KHCQTNVPGVFAVGDVNGGLQFTYISLDDFRVVYSYLAGDGSYTLEDRLNVPNTMFIT
                     PALSQVGLTESQAADLKLPYAVKEIPVAAMPRGHVNGDLRGAFKAVVNTETKEILGAS
                     IFSEGSQEIINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI"
     gene            1435..>1696
                     /locus_tag="AC0DU4_002138"
     CDS             1435..>1696
                     /locus_tag="AC0DU4_002138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1727 domain-containing protein"
                     /protein_id="HIN4238039.1"
                     /translation="MNLKTTLGLLAGRSSHFVLSRLGRGSTLPGKVALQFDKDILQNL
                     AKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMI"
BASE COUNT          510 a          377 c          329 g          480 t
ORIGIN      
        1 cgaataggag gaactctaaa tgttaactta tgatttaatc gttatcggat ttggtaaagc
       61 tggtaaaaca ctagcaggta aattggcttc agctggcaaa aaagttgccc tcgttgaacg
      121 tagcaaagct atgtacggtg gaacttgtat caacatcggt tgtatcccaa ctaaaacttt
      181 gctggttgct gctgagaaag acttgtcttt tgaagaagtc attgctacca aaaacacgat
      241 cactggtcgc ctcaacggta aaaactatac gactgttgct ggtactggcg tcgatatctt
      301 tgatgctgaa gctcacttcc tttcaaataa agtcatcgaa atccaagctg gtgatgaaaa
      361 acaagaattg actgctgaaa ctatcgtcat caacactggt gctgtttcaa acgtcttgcc
      421 aatccctgga cttgctacaa gcaaaaacgt ctttgactca acaggtatcc aaagcttgga
      481 taaattgcct gaaaaacttg gagtccttgg tggcggaaat atcggtcttg aatttgctgg
      541 cctttacaat aaactaggaa gcaaggttac agtcctagat gccttggata cattcctacc
      601 tcgtgcagaa ccttccatcg cagctcttgc taaacaatac ctggaagaag acggtattga
      661 attgcttcaa aatatccata ctactgaaat taaaaacgac ggtgaccaag tgcttgtcgt
      721 aactgaagac gaaacttacc gtttcgacgc ccttctctac gcaactggac gcaaaccaaa
      781 tgtagaacca cttcaacttg aaaatacaga tattgaacta actgaacgtg gcgctattaa
      841 agtagataaa cactgtcaaa caaacgttcc tggtgtcttt gcagttggag atgtcaacgg
      901 tggtcttcaa tttacttaca tttcacttga tgacttccgt gttgtttaca gctaccttgc
      961 tggagatggc agctacacac ttgaggaccg tctcaatgta ccaaatacta tgttcatcac
     1021 acctgcactt tcacaagttg gtttgactga aagccaagca gctgatttga aacttccata
     1081 cgcagtgaaa gaaatccctg ttgcagccat gcctcgtggt cacgtaaatg gagaccttcg
     1141 cggagctttc aaagctgttg ttaatactga aacaaaagaa attcttggtg caagcatctt
     1201 ctcagaaggt tctcaagaaa tcatcaacat cattactgtt gctatggaca acaagattcc
     1261 ttacacttac ttcacaaaac aaatcttcac tcacccaacc ttggctgaga acttgaatga
     1321 cttgtttgcg atttaagttg aaatctcatc ttaactgaca gccctctttg ggctgttttt
     1381 acttctacga aacaccaaat ctgtcttttc cctcttttgt gatataatag aaacatgaac
     1441 ttaaaaacta ctttgggcct tcttgctggg cgttcttccc acttcgtttt aagccgtctt
     1501 ggacgtggaa gtacgctccc agggaaagtc gcccttcaat ttgataaaga tattttacaa
     1561 aacctagcta agaactacga gattgtcgtt gtcactggaa caaatggaaa aaccctgaca
     1621 actgccctca ctgtcggcat tttaaaagag gtttatggtc aagttctaac caacccaagc
     1681 ggtgccaaca tgatta
//
LOCUS       DBMVGT010000148         1662 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.148, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000148 DBMVGT010000000
VERSION     DBMVGT010000148.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1662)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1662)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1662
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.148"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..437)
                     /locus_tag="AC0DU4_002139"
     CDS             complement(<1..437)
                     /locus_tag="AC0DU4_002139"
                     /EC_number="3.4.21.-"
                     /EC_number="3.4.21.105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="HIN4238040.1"
                     /translation="MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFG
                     AMYGPAIRLFPEQVWRLLSAIFVHIGWEHFIVNMLSLYYLGRQVEEIFGSKQFFFLYL
                     LSGMMGNLFVFVFSPKSLAAGASTSLYGLFAAIIVLRYATRNP"
     gene            complement(421..960)
                     /locus_tag="AC0DU4_002140"
     CDS             complement(421..960)
                     /locus_tag="AC0DU4_002140"
                     /EC_number="6.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030272 - 5-formyltetrahydrofolate
                     cyclo-ligase activity [Evidence IEA];
                     GO_process: GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="HIN4238041.1"
                     /translation="MKSELRKQVLHEMKAISQEQKQAIDQALTERLLHHPFYQEAKVI
                     ATYLSFSHEFQTRELIEQALKDGKKVLIPKTYPKGRMEFVAYDPQQLVKTSFALLEPQ
                     GDVEVVDASQIDLIHVPGLAFTTKGYRIGYGGGYYDRYLEHFSGRTLSTIYPCQIQDF
                     IPENHDIPVQEVLIDEGNL"
     gene            complement(972..>1662)
                     /locus_tag="AC0DU4_002141"
     CDS             complement(972..>1662)
                     /locus_tag="AC0DU4_002141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004180 - carboxypeptidase activity
                     [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="amidohydrolase"
                     /protein_id="HIN4238042.1"
                     /translation="DQFYGLHVRPDLKVGQIATNTHTLFAGTCEVKIRFKGKGGHAAF
                     PHEANDALVAASYFVTQVQSVVSRNVNPIEGAVVTFGVFQAGTTNNVITDTAFLHGTI
                     RALTQDMSLLVQKRVKTVAEGVAAAFDMEVEVELKQGGYLPVENNPALARELMDFFDE
                     KDGIELIDIEPAMTGEDFGYLLSKVDGVMFWLGIDSPYALHHPQMSPKEEVLAIGVAA
                     VSSFLKKKAAE"
BASE COUNT          496 a          401 c          345 g          420 t
ORIGIN      
        1 taaggattgc gagttgcata gcgaagaaca ataatcgcgg caaatagccc ataaagagag
       61 gtagaggcgc ctgctgctaa ggatttagga ctaaatacaa aaacaaagag attgcccatc
      121 attcctgata aaagatagag aaagaaaaac tgcttagaac cgaaaatctc ctctacctgc
      181 cttccaagat aataaagtga aagcatatta acaatgaaat gttcccaccc aatatgaaca
      241 aaaatggcag acaagagacg ccaaacctgc tcgggaaaga ggcgaatagc tggcccatac
      301 atggctccaa atcgaaataa tgtatctgcc ctgtcaaagt ttccgcctgc agtgaccaac
      361 attagtaaaa ataccaaggc cgtcactaag aggaagaaac tcgtcacagg gtaacgtcta
      421 tcaaagattt ccttcatcaa ttaatacctc ctgaacagga atatcatggt tttcaggtat
      481 aaagtcctga atttgacaag gatatatcgt actcaaagta cgaccagaaa aatgttccag
      541 atagcggtca taatagcctc caccgtatcc tatccgatat cctttcgtcg taaaagccag
      601 accaggaaca tgaatcaaat caatctgaga tgcatccacc acttccacat ctccctgtgg
      661 ctccagtaag gcaaaggaag tttttaccaa ctgttgcgga tcataggcca caaactccat
      721 gcgccccttg ggataagttt tgggtattaa aaccttcttg ccgtccttca gcgcctgctc
      781 aatcagttcc cgcgtttgaa actcatgaga aaaagagagg taggttgcga tgaccttggc
      841 ttcttggtag aagggatggt gtaaaagccg ctcggttaaa gcttggtcta tagcctgttt
      901 ttgctcttga gatatagcct tcatttcatg caagacttgc ttgcgtaatt ccgatttcat
      961 agacaagccc tctattctgc tgccttcttt ttcaggaaac tagacaccgc agccacccca
     1021 atagctaaga cttcttcctt aggactcatt tgagggtgat gaagagcgta gggactatcg
     1081 atacctagcc aaaacatcac gccatcaacc tttgaaagga gataaccaaa gtcctcgcct
     1141 gtcatagcag gttcgatatc aatcaactcg attccgtctt tctcgtcaaa gaagtccatc
     1201 agttcacgcg ccaaggctgg attgttctca acaggtaggt atccaccttg tttgagttcc
     1261 acttcgactt ccatatcaaa ggcagctgca accccttctg caactgtttt taccctcttt
     1321 tgcaccaaga gactcatgtc ctgtgtcaag gcacgaatag ttccatgtaa aaaagctgtg
     1381 tctgtgatga cattgttggt ggttccagct tgaaaaacgc cgaaggtcac cactgctccc
     1441 tcgattgggt tgacattgcg gctaacaact gactgcactt gggtcacaaa gtaactagcc
     1501 gccaccaagg cgtcattggc ttcatgagga aaagctgcgt ggccaccttt gcctttgaaa
     1561 cggatcttca cctcgcaagt tcctgcaaag agtgtatgag tattagtcgc aatctggccg
     1621 actttcaaat ctggacgaac atggagacca tagaattgat ct
//
LOCUS       DBMVGT010000149         1572 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.149, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000149 DBMVGT010000000
VERSION     DBMVGT010000149.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1572)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1572
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.149"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..969
                     /locus_tag="AC0DU4_002142"
     CDS             <1..969
                     /locus_tag="AC0DU4_002142"
                     /EC_number="3.4.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA];
                     GO_function: GO:0005515 - protein binding [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="S1C family serine protease"
                     /protein_id="HIN4238043.1"
                     /translation="VVSVITYSANRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEA
                     YIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISSEKVTTVAEFGDSS
                     KLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINP
                     GNSGGPLINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRP
                     ALGIQMVNLSNVSTSDIRRLNIPSNVTSGVIVRSVQSNMPANGHLEKYDVITKVDDKE
                     IASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES"
     gene            1027..>1572
                     /locus_tag="AC0DU4_002143"
     CDS             1027..>1572
                     /locus_tag="AC0DU4_002143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HIN4238044.1"
                     /translation="MEKFEMISITDIQKNPYQPRKEFDREKLDELAQSIKENGVIQPI
                     IVRQSPVIGYEILAGERRYRASLLAGLRSIPAVVKQISDQEMMVQSIIENLQRENLNP
                     IEEARAYESLVEKGFTHAEIADKMGKSRPYISNSIRLLSLPEQILSEVENGKLSQAHA
                     RSLVGLNKEQQDYFFQRIIEED"
BASE COUNT          545 a          290 c          306 g          431 t
ORIGIN      
        1 gttgtttctg ttattactta ttcggcaaac agacaaaata gcgtatttgg caatgatgat
       61 actgacacag attctcagcg aatctctagt gaaggatctg gagttattta taaaaagaat
      121 gataaagaag cttacatcgt caccaacaat cacgttataa atggcgccag caaagtagat
      181 attcgattgt cagatgggac taaagtacct ggagaaattg tcggagctga cactttctct
      241 gatattgctg tcgtcaaaat ctcttcagaa aaagtgacaa cagtagctga gtttggtgat
      301 tctagtaagt taactgtagg agaaactgct attgccatcg gtagcccgtt aggttctgaa
      361 tatgcaaata ctgtcactca aggtatcgta tccagtctca atagaaatgt atccttaaaa
      421 tcggaagatg gacaagctat ttctacaaaa gccatccaaa ctgatactgc tattaaccca
      481 ggtaactctg gcggcccact gatcaatatt caagggcagg ttatcggaat tacctcaagt
      541 aaaattgcta caaatggagg aacatctgta gaaggtcttg gtttcgcaat tcctgcaaat
      601 gatgctatca atattattga acagttagaa aaaaacggaa aagtgacgcg tccagctttg
      661 ggaatccaga tggttaattt atctaatgtg agtacaagcg acatcagaag actcaatatt
      721 ccaagtaatg ttacatctgg tgtaattgtt cgttcggtac aaagtaatat gcctgccaat
      781 ggtcaccttg aaaaatacga tgtaattaca aaagtagatg acaaagagat tgcttcatca
      841 acagacttac aaagtgctct ttacaaccat tctatcggag acaccattaa gataacctac
      901 tatcgtaacg ggaaagaaga aactacctct atcaaactta acaagagttc aggtgattta
      961 gaatcttaat tgacatctat gtaaagaaag ctttacataa gagaaaagat gtgttagtgt
     1021 agaatcatgg aaaaatttga aatgatttct atcacagata tacaaaaaaa tccctatcaa
     1081 ccccgaaaag aatttgatag agaaaaacta gatgaactag cacagtctat caaagaaaat
     1141 ggggtcattc aaccgattat tgttcgtcaa tctcctgtta ttggttatga aatccttgca
     1201 ggagagagac gctatcgggc ttcactttta gctggtctac ggtctatccc agctgttgtt
     1261 aaacagattt cagaccaaga gatgatggtc cagtccatta ttgaaaattt acagagagaa
     1321 aatttaaacc caatagaaga agcacgcgcc tatgaatctc tcgtagagaa aggattcacc
     1381 catgctgaaa ttgcagataa gatgggcaag tctcgtccat atatcagcaa ctccattcgt
     1441 ttactttcct tgccagaaca gattctctca gaagtagaaa atggcaaact atcacaagcc
     1501 catgcgcgtt ccctagttgg gttaaataag gaacaacaag actatttctt tcaacggatt
     1561 atagaagaag at
//
LOCUS       DBMVGT010000150         1562 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.150, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000150 DBMVGT010000000
VERSION     DBMVGT010000150.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1562)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1562)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.150"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1386
                     /gene="comA"
                     /locus_tag="AC0DU4_002144"
     CDS             <1..1386
                     /gene="comA"
                     /locus_tag="AC0DU4_002144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="HIN4238045.1"
                     /translation="FATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVL
                     FSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEANAVLFSSIIEDINGIETIK
                     SLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHLLLNVGILWMGAVLVMD
                     GKMSLGQLITYNTLLVYFTNSLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTV
                     EDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVN
                     FYDPSQGEISLGSVNLNQIDKKALRQYINYLPQQPYVFNGTILENLLLGAKEGTTQED
                     ILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEA
                     TSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLA
                     QGGFYAHLVNS"
     gene            1399..>1562
                     /locus_tag="AC0DU4_002145"
     CDS             1399..>1562
                     /locus_tag="AC0DU4_002145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComB"
                     /protein_id="HIN4238046.1"
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKE
                     MSLSTRATVEP"
BASE COUNT          411 a          296 c          393 g          462 t
ORIGIN      
        1 tttgcgacac gcaggacagg ggagatcgtg tctcgtttta cagatgctaa cagtatcatc
       61 gatgcgctgg cttcgaccat cctttcgatt ttcctagatg tgtcaacggt tgtcattatt
      121 tcccttgttc tattttcaca aaataccaat ctctttttca tgactttatt ggcgcttcct
      181 atctacacag tgattatctt tgcctttatg aagccgtttg aaaagatgaa tcgggatacc
      241 atggaagcca atgcggttct gttttcttct atcattgagg acatcaacgg tattgagact
      301 atcaagtcct tgaccagtga aagtcagcgt taccaaaaaa ttgacaagga atttgtggat
      361 tatctgaaga aatcctttac ctatagtcga gcagagagtc agcaaaaggc tctgaaaaag
      421 gttgcccatc tcttgcttaa tgtcggcatt ctctggatgg gggctgttct ggtcatggat
      481 ggcaagatga gtttggggca gttgattacc tataatacct tgctggttta ctttaccaat
      541 tctttggaaa atatcatcaa tctgcaaacc aagcttcaga cagcgcaggt tgccaataac
      601 cgtctaaatg aagtgtatct agtagcttct gagtttgagg agaagaaaac agttgaggat
      661 ttgagcttga tgaagggaga tatgaccttc aagcaggttc attacaagta tggctatggt
      721 cgagacgtct tgtcggatat caatttaacc gttccccaag ggtctaaggt ggcttttgtg
      781 gggatttcag ggtcaggtaa gacgactttg gccaagatga tggttaattt ttacgaccca
      841 agtcaagggg agattagtct gggtagtgtc aatctcaatc agattgataa aaaagccctg
      901 cgccagtaca tcaactatct gcctcaacag ccctatgtct ttaacggaac gattttggag
      961 aatcttcttt tgggagccaa ggaggggacg acacaggaag atatcttacg ggcggtcgaa
     1021 ttggcagaga ttcgagagga tatcgagcgc atgccactga attatcagac agaattgact
     1081 tcggatgggg cagggatttc aggtggtcaa cgtcagagaa tcgctttggc gcgtgctctc
     1141 ttgacagatg cgccggtctt gattttggat gaggcgacta gcagtttgga tattttgaca
     1201 gagaagcgga ttgtcgataa tctcatagct ttggacaaga ccttgatttt cattgctcac
     1261 cgcttgacta ttgctgagcg gacagagaag gtagttgtct tggatcaggg caagattgtc
     1321 gaagaaggaa agcatgctga tttgcttgca cagggtggct tttacgccca tttggtcaat
     1381 agctagaaag aggagaggat gaaaccagaa tttttagaaa gtgcggagtt ttataatcgt
     1441 cgttaccata atttttccag tagtgtgatt gtacccatgg cccttctgct cgtgttttta
     1501 cttggctttg caactgttgc agagaaggag atgagtttgt ccactagagc tactgtcgaa
     1561 cc
//
LOCUS       DBMVGT010000151         1551 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.151, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000151 DBMVGT010000000
VERSION     DBMVGT010000151.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1551)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1551)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.151"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..339
                     /locus_tag="AC0DU4_002146"
     CDS             <1..339
                     /locus_tag="AC0DU4_002146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000772208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004637 - phosphoribosylamine-glycine
                     ligase activity [Evidence IEA];
                     GO_process: GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide synthetase C
                     domain-containing protein"
                     /protein_id="HIN4238047.1"
                     /translation="ITDILDSKEPNIMWTDKGVTLGVVVASKGYPLDYERGVELPAKT
                     EGDVITYYAGAKFAENSRALLSNGGRVYMLVTTADTVKEAQASIYQELSQQKIEGLFY
                     RTDIGSKAIK"
     gene            530..1021
                     /gene="purE"
                     /locus_tag="AC0DU4_002147"
     CDS             530..1021
                     /gene="purE"
                     /locus_tag="AC0DU4_002147"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009320 - phosphoribosylaminoimidazole
                     carboxylase complex [Evidence IEA];
                     GO_function: GO:0004638 - phosphoribosylaminoimidazole
                     carboxylase activity [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HIN4238048.1"
                     /translation="MTKPIISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTP
                     DLMFKHAEEAYSRGIKVIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGVDSLYS
                     IVQMPGGVPVATMAIGEAGATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSN
                     ELI"
     gene            1008..>1551
                     /locus_tag="AC0DU4_002148"
     CDS             1008..>1551
                     /locus_tag="AC0DU4_002148"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HIN4238049.1"
                     /translation="MSSSKTIGIIGGGQLGQMMAISAIYMGHKVIALDPAADCPVSRV
                     AEIIVAPYNDVDALRQLADRCDVLTYEFENVDADGLDAVIKDGQLPQGTDLLRISQNR
                     IFEKDFLSNKAQVTVAPYKVVTSSLDLADIDLSKNYVLKTATGGYDGHGQKVIRSEVD
                     LEAAYALAESADCVLEEFVNF"
BASE COUNT          441 a          357 c          389 g          364 t
ORIGIN      
        1 atcacagata tcctggatag caaggagcca aatatcatgt ggacggacaa gggtgtgact
       61 ctgggtgtgg ttgtcgcatc caagggctac ccgctagact atgaaagggg cgttgagttg
      121 ccagccaaga cagaaggcga tgtcatcacc tactatgcag gggctaagtt tgcggaaaat
      181 agcagagcac tgctctcaaa cggcggacga gtttatatgc tcgttaccac agcagatacc
      241 gtcaaagaag cccaagccag catctaccaa gaactatccc aacaaaaaat agaaggactc
      301 ttctaccgaa cagatatcgg aagcaaggca attaagtaaa gatataagaa taacgcgccg
      361 tagtcgccaa acacgataat ggtcgtcgtg gtgaaaagac cagaacagtg aatgttctgg
      421 tcagggggaa atttggagac cgtaggctca aagtttagga atgaaaccga aggtttgctt
      481 ccgcctccat cacctaagat cattattaaa aaagaagaaa aggaaaatta tgaccaaacc
      541 aattatttcc atcatcatgg gctcaaaatc cgattgggca accatgcaaa aaacagcaga
      601 agtcttagac cgcttcggtg tagcctacga aaagaaagtt gtttctgccc accgtacacc
      661 tgatctcatg ttcaaacatg cagaagaagc atatagccgt ggtattaagg tcatcatcgc
      721 aggtgctgga ggcgcagccc acttgccagg aatggtagct gccaaaacaa cccttcctgt
      781 cataggggta cctgtcaagt ctcgtgctct tagtggagtg gattcactct attctatcgt
      841 tcagatgccg ggtggggtgc ctgttgcgac catggctatc ggtgaagctg gagcgactaa
      901 cgcagctctc tttgccctcc gtctcctctc tgtagaagat aagtccattg cggatgcact
      961 tgccaacttt gctgaagaac aaggaaaaat cgcagaggag tcgtcaaatg agctcatcta
     1021 aaacaatcgg aattatcggt ggcggtcaac tgggtcagat gatggccatt tctgctatct
     1081 acatgggcca caaggttatc gcgctggatc ctgcggcgga ttgcccggtc tctcgtgtgg
     1141 cggaaatcat tgtggcacct tataacgatg tagacgccct ccgtcagttg gcagaccgtt
     1201 gcgatgtcct cacttacgag tttgaaaatg tcgacgctga cggtttggat gccgttatca
     1261 aggatggaca actccctcaa gggacagacc tgctccgcat ttcgcaaaat cgtatttttg
     1321 aaaaggactt tttgtcaaac aaggctcaag tcactgtggc accctacaag gtcgtgactt
     1381 ctagcctaga cttggcagat atcgacttgt cgaaaaacta tgtcctcaag actgcgactg
     1441 gtggctacga tggtcatgga caaaaggtta ttcgttcaga agtagacttg gaagcagcct
     1501 atgcgctagc agaatcagca gactgcgtct tggaagaatt tgtcaacttt g
//
LOCUS       DBMVGT010000152         1547 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.152, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000152 DBMVGT010000000
VERSION     DBMVGT010000152.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1547)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1547)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1547
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.152"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..117
                     /locus_tag="AC0DU4_002149"
     CDS             <1..117
                     /locus_tag="AC0DU4_002149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000772208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HIN4238050.1"
                     /translation="VTTVATVKEAQASIYQELSQQKIEGLFYRTDIGSKASK"
     gene            374..490
                     /locus_tag="AC0DU4_002150"
     CDS             374..490
                     /locus_tag="AC0DU4_002150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazole carboxylase"
                     /protein_id="HIN4238051.1"
                     /translation="MKERLDDNPIVQGNWKTLGFQFRHETPLVAAAVPHKLR"
     gene            520..1008
                     /gene="purE"
                     /locus_tag="AC0DU4_002151"
     CDS             520..1008
                     /gene="purE"
                     /locus_tag="AC0DU4_002151"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009567721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009320 - phosphoribosylaminoimidazole
                     carboxylase complex [Evidence IEA];
                     GO_function: GO:0004638 - phosphoribosylaminoimidazole
                     carboxylase activity [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HIN4238052.1"
                     /translation="MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPD
                     LMFKHAEEARSRGIKIIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGVDSLYSI
                     VQMPGGVPVATMAIGEAGATNAALFALRILSVEDKSIADALANFAEEQGKITEESSNE
                     LI"
     gene            995..>1547
                     /locus_tag="AC0DU4_002152"
     CDS             995..>1547
                     /locus_tag="AC0DU4_002152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HIN4238053.1"
                     /translation="MSSSKTIGIIGGGQLGQMMAISAIYMGHKVIALDPAADCPASRV
                     AEIIVAPYNDVDALRQLADRCDVLTYEFENVDADGLDAVIKDGQLPQGTDLLRISQNR
                     IFEKDFLSNKAQVTVAPYKVVTSSLDLADIDLSKNYVLKTATGGYDGHGQKVIRSEVD
                     LEAAYALADSADSADCVLEEFVNF"
BASE COUNT          450 a          356 c          379 g          362 t
ORIGIN      
        1 gttaccacag tagccaccgt caaagaagcc caagccagca tctaccaaga actatcccaa
       61 caaaaaatag aaggactctt ctaccgaaca gatatcggaa gcaaggcaag taagtaaaga
      121 tataagaata acgcgacgca gtcgccaaac acgataatgg tcgtcgtggt gaaaagacca
      181 gaacagtgaa tgttctggtc agggggaaac tttgagacct taggctcaaa gtttaggaat
      241 gaaaccgaag gtttgcttcc gcctccatca cctaagacca ttatcaaaaa gaaaaataaa
      301 aattcacaaa atacgttaat ggtcgtatgg tttgcgagcg ttagcgagct aatatagaat
      361 aatcaccgcc gttgtgaaag aacgattgga tgataatcca atcgttcagg gaaattggaa
      421 gaccttgggt ttccaattta ggcatgagac acctttggtg gctgctgccg tccctcacaa
      481 gctaaggtga ttgttgaaaa agaggaaaaa ggagaagaaa tgaaaccagt aatttccatc
      541 atcatgggct caaaatccga ctgggcaacc atgcaaaaaa cagcagaagt cctagaccgc
      601 ttcggtgtag cctacgaaaa gaaagttgtt tccgcacacc gtacaccaga cctcatgttc
      661 aaacatgcag aagaagcccg tagtcgtggc atcaagatca tcatcgcagg tgctggtggc
      721 gcagcgcatt tgccaggcat ggtagctgcc aaaacaaccc ttccagtcat tggtgtgcca
      781 gtcaagtctc gtgctcttag tggagtggat tcactctatt ctatcgttca gatgccgggt
      841 ggggtgcctg ttgcgaccat ggctatcggt gaagctggag cgactaacgc agctctcttt
      901 gccctccgta tcctctctgt agaagataag tccattgcgg atgcacttgc caactttgct
      961 gaagaacaag gaaaaatcac agaggagtcg tcaaatgagc tcatctaaaa caatcggaat
     1021 tatcggtggc ggtcaactgg gtcagatgat ggccatttct gctatctaca tgggccacaa
     1081 ggttatcgcg ctggatcctg cggcggattg cccggcctct cgcgtggcgg aaatcattgt
     1141 ggcaccttat aacgatgtgg acgccctccg tcagttggca gaccgttgcg atgtcctcac
     1201 ttacgagttt gaaaatgtcg acgctgacgg tttggatgcc gttatcaagg atggacaact
     1261 ccctcaagga acagatctgc tccgcatttc gcaaaatcgt atttttgaaa aggacttttt
     1321 gtcaaacaag gctcaagtca ctgtggcacc ctacaaggtc gtgacttcta gcctagactt
     1381 ggcagatatc gacttgtcga aaaactatgt cctcaagact gcgactggtg gctacgatgg
     1441 tcatggacaa aaggttattc gttcagaagt agacttggaa gcagcctatg cgctagcaga
     1501 ctcagcagac tcagcagact gcgtcttgga agaatttgtc aactttg
//
LOCUS       DBMVGT010000153         1483 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.153, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000153 DBMVGT010000000
VERSION     DBMVGT010000153.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1483)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.153"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..189
                     /locus_tag="AC0DU4_002153"
     CDS             <1..189
                     /locus_tag="AC0DU4_002153"
                     /EC_number="1.8.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin family protein"
                     /protein_id="HIN4238054.1"
                     /translation="ETNPEFTFIRMDRDQYMDLTKLWDVYGIPSLVVLEKDKEIGRFV
                     NRDRKSKQQINDFLAGLK"
     gene            205..831
                     /gene="ytpR"
                     /locus_tag="AC0DU4_002154"
     CDS             205..831
                     /gene="ytpR"
                     /locus_tag="AC0DU4_002154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtpR family tRNA-binding protein"
                     /protein_id="HIN4238055.1"
                     /translation="MIFTYNKEHVGDVLMVIVKNSGDAKLDVERKGKVARVFLKDNGE
                     TVAWNIFEVSSLFEIAERGQVFLTDEQVARLNQELQAEGFTEEIVNDKEPKFVVGEIV
                     EMVAHPDSDHLNICQVAVASDKTVQIVAGAPNARVGLKTIVALPGAMMPKGNLIFPGE
                     LRGEKSFGMMCSPRELHLPNAPQKRGVLELSEDQVVGTPFDSAKHWTA"
     gene            873..>1483
                     /locus_tag="AC0DU4_002155"
     CDS             873..>1483
                     /locus_tag="AC0DU4_002155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HIN4238056.1"
                     /translation="MAKNVVITGATSGIGEAIARAYLEQGEDVVLTGRRIDRLEALKA
                     EFAETFPNQTVWTFLLDVTDMVMVKTVCSDILETIGQIDILVNNAGLALDLAPYQDYE
                     ELDMLTMLDTNVKGLMAVTRCFLPAMVKANQGHIINMGSTAGIYAYAGAAVYSATKAA
                     VKTFSDGLRIDTIATDIKVTTIQPGIVETDFSTVRFHGDKERAA"
BASE COUNT          443 a          275 c          371 g          394 t
ORIGIN      
        1 gagaccaatc cagagttcac ctttattcga atggaccgag atcagtatat ggatttgacc
       61 aaactctggg atgtttacgg aattcctagc cttgttgttc tagaaaagga caaggaaatc
      121 ggtcgttttg tcaatcgcga ccgtaaaagc aagcaacaaa tcaatgactt tttagcagga
      181 ctgaaatagg agaaaaagga aacaatgatt tttacatata ataaagaaca tgtcggtgat
      241 gtccttatgg tcatcgtgaa aaatagcgga gatgccaaac tggatgtgga gcgcaaaggc
      301 aaggtagccc gtgtttttct caaagataat ggggaaacag tggcttggaa tattttcgaa
      361 gtttcaagtt tatttgaaat tgcagagcgc ggtcaagtct ttttgacaga tgagcaagtc
      421 gctcgtttga accaagagtt gcaggcggaa ggttttacag aagaaattgt taatgataag
      481 gaacctaagt ttgttgtcgg tgaaattgtt gagatggtag cccatccaga tagtgaccac
      541 ctcaacatct gccaagttgc agtcgcaagt gataagactg tacaaatcgt tgcaggagct
      601 cccaatgcgc gtgtggggtt gaaaaccatt gtcgcgcttc ctggagctat gatgccaaaa
      661 gggaatctca ttttcccagg tgaacttcgt ggtgaaaaga gttttggtat gatgtgcagt
      721 cctcgtgaat tgcatctgcc aaatgctcca caaaaacgtg gggtgcttga attatcagaa
      781 gaccaagttg tcggaacacc atttgactca gctaaacact ggactgccta agaagttgtt
      841 aatatctgat agaccagcta gaaggaaata agatggcaaa aaatgttgtg attacaggag
      901 cgacatcagg aatcggtgaa gcgattgcgc gtgcttatct ggagcagggt gaggatgtcg
      961 ttctaacagg acgacggata gacagactag aagctcttaa ggcggagttt gcagaaactt
     1021 ttccaaatca aacagtttgg acttttctcc tagatgtcac ggatatggtc atggtaaaga
     1081 ctgtctgctc tgatatttta gaaacgatag gtcagattga catcctggtc aataacgcag
     1141 gactggctct tgacttagct ccctatcaag actatgaaga gttggatatg ctgaccatgt
     1201 tggataccaa tgtcaaaggt ttgatggcag tcactcgctg tttcttgcca gcaatggtaa
     1261 aagccaatca aggtcatatt atcaatatgg ggtcaaccgc aggaatttat gcctatgctg
     1321 gtgcagctgt ttactcagcc accaaggcgg cagttaagac cttttcagat ggactgcgaa
     1381 ttgataccat cgcaacggat atcaaggtga cgaccattca gcctggaatt gtcgaaacag
     1441 atttttctac agtgcgtttt catggtgata aagaacgagc tgc
//
LOCUS       DBMVGT010000154         1483 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.154, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000154 DBMVGT010000000
VERSION     DBMVGT010000154.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1483)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.154"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..755)
                     /gene="rmuC"
                     /locus_tag="AC0DU4_002156"
     CDS             complement(<1..755)
                     /gene="rmuC"
                     /locus_tag="AC0DU4_002156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombination protein RmuC"
                     /protein_id="HIN4238057.1"
                     /translation="MESLLILLLIANLAGLFLIWQRQDRQEKHLSKSLEDQADHLSDQ
                     LDYRFDQARQASQLDQKDLEVAVSDRLQEVRIELHQGLTQVRQEMTDNLLQTRDKTDQ
                     RLQALQESNEQRLEQMRQTVEEKLEKTLQTRLQASFETVSKQLESVNRGLGEMQTVAR
                     DVGALNKVLSGTKTRGILGELQLGQIIEDIMTPAQYEREYATVENSSERVEYAIKLPG
                     QGDQEYVYLPIDSKFPLADYYRLEEAYEVGDKD"
     gene            complement(757..1419)
                     /locus_tag="AC0DU4_002157"
     CDS             complement(757..1419)
                     /locus_tag="AC0DU4_002157"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000006147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004788 - thiamine diphosphokinase
                     activity [Evidence IEA];
                     GO_process: GO:0006772 - thiamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HIN4238058.1"
                     /translation="MSEYKLSENNWTRVAVFAGGDRGHYRTDFDAFVGVDRGSLWVLE
                     EDLLLALAVGDFDSVTEEERQVIQKRAQHFVQARPEKDDTDLELALLTIFEQNPQAEV
                     TIFGALGGRIDHMLANVFLPSNPKLAPYMRQIEIEDGQNLIAYCSEGTSQLEPRSDYD
                     YLAFMPVRDSQLTILGAKYELTEENFFFKKVYASNEYIDREVSVTCPDGYVVVLHSKD
                     RR"
     gene            complement(1382..>1483)
                     /locus_tag="AC0DU4_002158"
     CDS             complement(1382..>1483)
                     /locus_tag="AC0DU4_002158"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522408.1"
                     /note="catalyzes the interconversion of D-ribulose
                     5-phosphate to xylulose 5-phosphate; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HIN4238059.1"
                     /translation="QAKEAGATVFVAGSYVFKGDVNERVQTLRKQLD"
BASE COUNT          372 a          377 c          303 g          431 t
ORIGIN      
        1 tcatccttgt cacctacttc ataggcttct tctaagcggt aataatctgc cagtggaaac
       61 ttagagtcaa ttggtaggta gacgtattct tggtcgcctt gtccgggtaa cttgatggca
      121 tactccactc gttcactaga gttttcaacc gttgcgtatt ctcgttcgta ctgggcaggt
      181 gtcatgatgt cttcaataat ttgccccagt tgcaattctc ccagaatccc tcgcgtcttg
      241 gttccagaga gaaccttgtt aagagctccg acatcacggg caactgtctg catttctcca
      301 agaccacgat tgacagactc cagttgttta gaaactgtct caaaggaagc ctgtaagcgt
      361 gtctgcaagg tcttttctag tttttcctcg accgtctggc gcatttgttc caaacgttgc
      421 tcatttgatt cctgcaaggc ttggagacgt tggtctgtct tgtctctagt ttggaggaga
      481 ttatctgtca tttcttgacg gacttgggtc aggccttggt gcaattcaat ccgcacttct
      541 tgcaaacggt cgctgacagc cacttccaaa tctttttggt ctaactggct ggcttgtctg
      601 gcttggtcaa agcggtaatc caactggtct gacaaatgat ctgcctgatc ctccaagctc
      661 ttacttaagt gtttctcctg cctatcctgt ctttgccaaa tcagaaagag accagctagg
      721 ttggcaatta ataatagaat aagtaaactt tccatcctac ctcctgtcct tgctatgcag
      781 tacgaccaca taaccatctg ggcaagtcac cgacacttcc ctatctatat attcgttaga
      841 agcgtacact tttttaaaga aaaaattctc ctctgtcaac tcatacttag ctccaagaat
      901 agtcagctgg ctatcccgaa ctggcataaa ggctagatag tcgtagtctg aacgaggttc
      961 tagctgactg gtcccttctg aacaataggc aatcaaattt tgcccatcct caatttctat
     1021 ttgacgcata tagggtgcca acttaggatt gctaggtaga aagacattgg ccaacatatg
     1081 gtcaatacgg ccacccaagg caccgaaaat agtgacctca gcctgaggat tttgttcaaa
     1141 gatggttaag agagccaatt ccagatctgt atcatccttt tctggtcggg cttggacaaa
     1201 atgctgggca cgtttttgaa tcacctgtcg ctcttcttcc gtcacagaat caaaatcccc
     1261 aactgctaga gcaagaagca agtcttcttc caagacccag agcgagcctc gatccacccc
     1321 aacaaaagca tcaaaatctg tccgataatg accgcggtct ccgcctgcaa aaacggcaac
     1381 cctagtccag ttgttttctg agagtttgta ctcgctcatt gacatctccc ttaaagacat
     1441 aggaacctgc tacaaaaacg gtcgcaccag cttctttagc ttg
//
LOCUS       DBMVGT010000155         1481 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.155, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000155 DBMVGT010000000
VERSION     DBMVGT010000155.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1481)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.155"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..402
                     /locus_tag="AC0DU4_002159"
     CDS             <1..402
                     /locus_tag="AC0DU4_002159"
                     /EC_number="3.4.11.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004177 - aminopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HIN4238060.1"
                     /translation="EGIKVIFKDGQIVDITAEKGDQVMKDLVFENAGARALGECALVP
                     DPSPISQSGITFFNTLFDENASNHLAIGAAYATSLVDGAEMSEEELEAAGLNRSDVHV
                     DFMIGSNQMDIDGIREDGTRVPLFRNGNWAN"
     gene            412..642
                     /locus_tag="AC0DU4_002160"
     CDS             412..642
                     /locus_tag="AC0DU4_002160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000901571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HIN4238061.1"
                     /translation="MLGSMFVGLLVGFLAGAMTNRGERMGCFGKMFLGWIGAFLGHLL
                     FGTWGPVLSGTAIIPAVLGAMIVLAIFWRRGS"
     gene            955..>1481
                     /locus_tag="AC0DU4_002161"
     CDS             955..>1481
                     /locus_tag="AC0DU4_002161"
                     /EC_number="5.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_function: GO:0140098 - catalytic activity, acting on
                     RNA [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="pseudouridine synthase"
                     /protein_id="HIN4238062.1"
                     /translation="MRLDKFLVACAVGSRTEVKNLLKAGRVTVNGKKEKSAKLQIDEK
                     IDEIRFDGQVLEYEEFVYYMMNKPKGVISATEDPKHRTVLDLLDDLARSKEVFPVGRL
                     DINTHGLLLLTNDGQLAHVLLSPKRHVDKTYLAQVKGIMTQEDVETFAEGIPLKDFTC
                     KPAILELVSIDTEKN"
BASE COUNT          422 a          257 c          388 g          414 t
ORIGIN      
        1 gaaggcatta aggtgatctt taaggatgga caaatcgtag atatcactgc tgagaagggt
       61 gatcaggtta tgaaagacct tgtctttgaa aatgcgggtg cgcgtgcctt gggtgaatgt
      121 gccttggtac cagatccaag tccaatttct cagtcaggca ttaccttctt taacaccctt
      181 ttcgatgaaa atgcgtcaaa ccacttggct atcggtgcag cctatgcgac tagccttgtt
      241 gatggagcgg agatgagcga agaggagctt gaagctgcag ggcttaaccg ttcagatgtt
      301 cacgtagact ttatgattgg ttctaaccaa atggatatcg atggtattcg tgaggatgga
      361 acgcgggtac ctcttttccg taatgggaat tgggcaaatt aaggagataa tatgttagga
      421 agtatgttcg ttggtctcct agtgggattt ttagcaggtg ctatgaccaa tcgtggagag
      481 cgaatgggat gttttggaaa aatgtttctc ggttggatcg gagcctttct aggtcacttg
      541 ctctttggaa cttgggggcc agttttatca ggaacagcta ttatcccagc tgttttaggt
      601 gccatgattg tcttagctat tttttggaga cgaggaagtt aatttcctaa atctgatact
      661 caatgaaaat caaagagcaa actaggaaac tagccgcagg ttgctcaaag cactgctttg
      721 aggttgcaga tagaactgac gaagtcagct aaaaacactg ttttgaggtt gcagatagaa
      781 ctgacgaagt cagctaaaaa cactgttttg aggttgcaga tagaactgac gaagtcagta
      841 acatatatac ggcaaggcga cgttgacgcg gtttgaagag atttttgaag agtatgaaac
      901 gaaaaggagg ttggtcattg taccagcctc cttttgatat gatataatag ttctatgaga
      961 ttagataaat ttttagttgc ctgtgcggtg ggaagtcgga ctgaggtcaa aaacttgctc
     1021 aaggctgggc gcgtgactgt aaatggtaaa aaagaaaaat cagctaaatt gcagattgat
     1081 gaaaaaatag atgagattcg ctttgatggg caagtgttgg agtatgaaga gtttgtctac
     1141 tacatgatga acaagcccaa aggagttatc tcagcgactg aggatcccaa gcacagaacc
     1201 gttctggact tgttggatga cttggcgcgg agtaaggaag ttttcccagt aggacgcttg
     1261 gatattaaca cgcatggtct tttgctcttg accaatgatg gtcagctggc tcatgttctt
     1321 ctttcgccca agcgtcatgt ggacaagact tatctggcac aagtcaaggg aatcatgacc
     1381 caagaagatg tggagacatt tgctgagggt attcctctca aagactttac ctgtaaaccc
     1441 gctatactgg agcttgtatc catagataca gaaaagaatc a
//
LOCUS       DBMVGT010000156         1464 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.156, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000156 DBMVGT010000000
VERSION     DBMVGT010000156.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1464)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1464)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.156"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            33..484
                     /locus_tag="AC0DU4_002162"
                     /pseudo
     CDS             33..484
                     /locus_tag="AC0DU4_002162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000013080.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
     gene            649..948
                     /locus_tag="AC0DU4_002163"
     CDS             649..948
                     /locus_tag="AC0DU4_002163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1827 family protein"
                     /protein_id="HIN4238063.1"
                     /translation="MKLINTTNSHSQLVKSQLESTDATLVEVYSAGNTDVIFTQAPLH
                     YEILISNKHRAIREPEIETIQEFFLKRKIDKASVDEANIKTLYSEKLIGISIPIK"
     gene            1209..>1464
                     /gene="tnpB"
                     /locus_tag="AC0DU4_002164"
     CDS             1209..>1464
                     /gene="tnpB"
                     /locus_tag="AC0DU4_002164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849103.1"
                     /note="TnpB, as the term is used for proteins encoded by
                     IS66 family insertion elements, is considered an accessory
                     protein, since TnpC, encoded by a neighboring gene, is a
                     DDE family transposase; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HIN4238064.1"
                     /translation="MIIQLSDLGQVHLVCSKIDMRQGIDSLAYVVKTHFELDPFSGQV
                     FLFCGGRKDRFKALYWDGQGFWLLYKRFENGRLTWPSTEKD"
BASE COUNT          504 a          289 c          263 g          408 t
ORIGIN      
        1 taataacgat actagataat gaggaaaatg caatggcaaa cccaactctc ggagaaaaaa
       61 agcgaataca gactatattg ctcgctatgg cgtatatgca gttatcccta atcctgaaca
      121 aaaacaaatt gttcttgttc aagaaccaaa tggtgcttgg ttcctaccat gtggagaaat
      181 tgaagcaggt gaaaatcatc aggaagccct aaagcgtgag ttgattgaag agcttggttt
      241 cacagcagaa attggtacct attacggaca aactgacgaa tatttctatt ctcgtcatcg
      301 tgatacctac tactacaatc ctgcctacct ctatgaagca acttctttca aagaagtaca
      361 aaagccacta gaaaacttta atcatattgc ctggttccct attgacgagg ctatccaaaa
      421 ccttaaacgt ggtagccata aatgggccat tgaatcttgg aaaaaacagc ataagattgg
      481 ctaatactct tcgaaaataa aattcaaacc acgtcagcgt cgccttaccg tactcaagta
      541 tagcctgcgg ctagcttcct agtttgctct ttgattttca ttgagtataa atcaagcgac
      601 tttattcaaa aagtgctata atagaattag aaaatcggag gaaatattat gaagcttatc
      661 aatacgacaa actcacactc gcaacttgta aaaagtcaac tagaaagtac cgatgcaacc
      721 cttgttgagg tttattctgc agggaataca gatgttattt ttacccaagc tccgcttcac
      781 tatgaaatcc tcatctcaaa caaacaccgt gctattcgtg agcctgaaat cgaaaccatt
      841 caagaatttt tcttgaaacg taaaattgat aaggcctctg ttgatgaagc caatatcaag
      901 acactctact cagagaaatt aattggaatt tcaatcccaa tcaagtaaga aaattgagta
      961 aaaactcgat ttgagagaaa gtccaataag tctttccata acaaaacgca tagtaacaag
     1021 agtttctaca cccactatta tacgttttta tcattttgaa atctgctgct aatcaatgaa
     1081 gaagcaaaga tcaaactaag cagctagtta caagttacgt aagcgcgtca taacaaggta
     1141 tctatcctaa ttccccaact tccagtatac tagataaaaa ataattatcg gaggaaaggt
     1201 attgtactat gataattcaa ctaagtgatt taggtcaagt tcaccttgtt tgtagcaaga
     1261 tagatatgag gcagggaata gactcattag cctatgtagt taaaacccac tttgaattgg
     1321 atcctttctc cggtcaagtc tttctctttt gtggtggacg taaagaccgc tttaaagccc
     1381 tttactggga tggtcaagga ttttggctac tatataaacg ctttgagaac ggcagactga
     1441 cttggcccag tacagaaaag gatg
//
LOCUS       DBMVGT010000157         1453 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.157, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000157 DBMVGT010000000
VERSION     DBMVGT010000157.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1453)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.157"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..375)
                     /locus_tag="AC0DU4_002165"
                     /pseudo
     CDS             complement(1..375)
                     /locus_tag="AC0DU4_002165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001098890.1"
                     /note="internal stop; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase family protein"
     gene            complement(356..1354)
                     /gene="ruvB"
                     /locus_tag="AC0DU4_002166"
     CDS             complement(356..1354)
                     /gene="ruvB"
                     /locus_tag="AC0DU4_002166"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0009378 - four-way junction helicase
                     activity [Evidence IEA];
                     GO_process: GO:0006281 - DNA repair [Evidence IEA];
                     GO_process: GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HIN4238065.1"
                     /translation="MSRILDNEIMGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEA
                     AKMRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELE
                     PGDVLFIDEIHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTR
                     AGMLSNPLRARFGITGHMEYYAHADLTEIVERTADIFEMEITHEAASELALRSRGTPR
                     IANRLLKRVRDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGG
                     PVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK"
BASE COUNT          427 a          376 c          260 g          390 t
ORIGIN      
        1 cgtacaccgt tctggatact tactcatagc atcacgagaa ctggtatagg aagcagtgtg
       61 aggactgtgc tgatgcatat agacctgatt tttcaattcc cactggtact gaggaaaatc
      121 ctctcacagc tttttctcca gtaataaggt ttcctcataa gaaaaatctg gatcaaagaa
      181 aatcacatct atatctgttt catgatcaaa aggggatttg tctgacaaaa gattccaaat
      241 gaaatttctg acagaacctg ctgccaacca cgagtctttc agaccaaggt ctcggatgat
      301 cgtcagaatg gccatcatat ctggattttc tctaaaagcc tctaagattt cttgcttatt
      361 tttcactgta ttcataacct aagtgctcat atgccttagc agtcgccacc cgtccagacc
      421 gtgtccgcat gataaaacct ttttgaatca agtaaggctc atacatatct tcaactgtct
      481 cacgctcttc ggcgatattc acagaaagag ttcctagacc aacaggtcct ccactgtaca
      541 tctcaatcat ggtacgaagg attttttgat ccacatagtc caaaccttca tggtcaacat
      601 ccagcatagt caaagcctta tcggtaataa tatcatcaat taccccattc cccattatct
      661 gggcaaaatc gcgcacgcgc ttgaggagac gattggcaat acgaggggtc ccacgactac
      721 gtagggccaa ctcagatgct gcctcatgag tgatttccat ctcaaaaata tctgccgtcc
      781 gctcgacaat ttctgtcaag tcagcatggg cataatactc catatggcct gtaatcccaa
      841 aacgtgcccg tagcggattg gagagcatac cagcccgagt cgtcgcacca atcaaggtaa
      901 aaggtggtaa ctccaaatga acactacgac taccctcacc agccccaatc ataatatcta
      961 tgtagaagtc ctccatagca ctataaagca cctcttccac tgacattggc aaacgatgga
     1021 tctcatcaat aaaaagtaca tccccaggct ctaactcatt caaaatagct accagatctc
     1081 cggctttttc aatgactgga cccgacgtct gcttaagatt gactcccagt tcgttggcaa
     1141 taacaaaggc catggtcgtt ttcccgagac ctggaggccc aaataagagc acatgatcca
     1201 gcgcttcatc ccgcattttg gcagcttcaa taaagatttg tagctggtcc ttgaccttat
     1261 cctgtccgat atattcacgt aaatactgag gacggagcgt gcgttctact aactcctcat
     1321 cccccattat ctcattatct aaaattctac tcatggctct attatatcaa aaaaccaagc
     1381 cacaaacaaa aaagccacct gattgggtga ctcctaagtt tagcacttat gtggtataat
     1441 attctacgac act
//
LOCUS       DBMVGT010000158         1443 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.158, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000158 DBMVGT010000000
VERSION     DBMVGT010000158.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1443)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.158"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..514
                     /locus_tag="AC0DU4_002167"
     CDS             <1..514
                     /locus_tag="AC0DU4_002167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="glycosyl hydrolase family 98 C-terminal
                     domain-containing protein"
                     /protein_id="HIN4238066.1"
                     /translation="LYPMNYEGDIFAQKLDNRWFVYNYKVNENVKQTGKLKFNSLEMN
                     VEFEPHTYGIFERISNGLKVNLNNFRTNKDSLWSNAQDANQAKKLPQLTKKGAIKWIE
                     EHYIKDTQFGEKRVTKIVLRGIDKLPTIHSLSGTNNSYDQPSLNFDQKNHMVTITINS
                     NGNLEFELHF"
     gene            529..1257
                     /locus_tag="AC0DU4_002168"
     CDS             529..1257
                     /locus_tag="AC0DU4_002168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class II aldolase/adducin family protein"
                     /protein_id="HIN4238067.1"
                     /translation="MSQDEKLIREQICDVCHKMWQLGWVAANDGNVSVRLDEDTILAT
                     PTGISKSFITPEKLVKLNLKGEILEAEGDYCPSSEIKMHIRCYEEREDVRSVVHAHPP
                     IATGFALAHIPLDTYSLIESAIVVGAIPITPFGVPSTMEVPEAITPYLPDHDVMLLEN
                     HGALTVGSDVITAYYRMETLELVAKTTFHGRMLLSTKGIEEQEIARPTLERLFSMREN
                     YKVTGRHPGYRKYNGDGSMKETEK"
     gene            1270..>1443
                     /gene="fucI"
                     /locus_tag="AC0DU4_002169"
     CDS             1270..>1443
                     /gene="fucI"
                     /locus_tag="AC0DU4_002169"
                     /EC_number="5.3.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935191.1"
                     /note="catalyzes the conversion of the aldose L-fucose
                     into the corresponding ketose L-fuculose; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-fucose isomerase"
                     /protein_id="HIN4238068.1"
                     /translation="MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLK
                     YPDGEPVECVISPS"
BASE COUNT          494 a          229 c          300 g          420 t
ORIGIN      
        1 gctgtatcct atgaattatg aaggagatat ctttgctcag aaattagata atagatggtt
       61 tgtctataat tacaaggtaa atgagaatgt taaacagact gggaaattaa aatttaattc
      121 tttagaaatg aatgttgaat ttgaacctca tacctatggt atttttgaga gaataagtaa
      181 tggattgaaa gtgaatttaa ataattttag aacaaataaa gattcactat ggtctaatgc
      241 tcaagatgca aatcaggcaa agaaactacc acaattgacc aagaaaggtg cgattaagtg
      301 gattgaagaa cattatatca aagatactca gtttggagag aaaagggtta caaagatagt
      361 attaagaggt atagataaac ttcctactat tcattcatta tcaggaacaa ataattccta
      421 tgatcagcca tctctcaatt ttgatcagaa aaatcatatg gttactatta ccattaacag
      481 taacggaaat cttgaattcg aacttcattt ttagaaagga gtgagtttat gtctcaagat
      541 gaaaaattaa ttcgtgaaca gatttgtgat gtttgtcata agatgtggca acttggttgg
      601 gttgctgcta acgatgggaa tgtatctgtt cgattagatg aggataccat tcttgcaaca
      661 cctactggta tcagcaaaag ttttattaca ccagaaaagc tggtgaagtt aaatcttaaa
      721 ggagagattt tagaagcaga aggtgattac tgtccttcta gtgaaattaa aatgcacatt
      781 cggtgctacg aagaacgtga ggatgtccgt tcagttgttc acgcgcatcc accgattgca
      841 acaggatttg ctcttgcaca cattccttta gatacttatt cactaattga gagcgcgatt
      901 gtggtaggag caattcctat aacgccattt ggagttccgt ctacaatgga agtgccagaa
      961 gcaattacac cttatctgcc cgatcatgat gtcatgctat tagaaaatca tggagctctg
     1021 actgtcggaa gcgatgtaat tacagcatac taccgtatgg aaactttaga attagtcgca
     1081 aagacaacct tccacggaag aatgttactt tctacaaagg gcattgagga gcaagaaatt
     1141 gctcgtccga ctttagaacg tctattctca atgcgagaaa attataaggt tacaggtcgt
     1201 cacccaggct accgtaaata taatggcgat ggtagtatga aagaaacaga aaaataagag
     1261 gaaaatagta tgattcaaca tccacgtatt ggtattcgtc cgactattga tggtcgtcgt
     1321 caaggtgtac gcgaatcact tgaagtgcaa acaatgaaca tggctaaaag tgtggcagat
     1381 ttgatttcaa gcacattgaa atatccagat ggagaacctg tggaatgcgt gatttctcca
     1441 tct
//
LOCUS       DBMVGT010000159         1441 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.159, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000159 DBMVGT010000000
VERSION     DBMVGT010000159.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1441)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.159"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            201..707
                     /locus_tag="AC0DU4_002170"
     CDS             201..707
                     /locus_tag="AC0DU4_002170"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000423398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HIN4238069.1"
                     /translation="MELRRPRLADKKAVLDMMTEFEKFQSPHDGGFWDTENFVYEDWL
                     ESNQEQEMGINLPEGWVPAIQLVAFSEKGQAVGFLNLRLRLSNFLLEEGGHIGYSIRP
                     SERGKGYAKETLRQGLQVAKEKNIKKALVTCSVNNPASRAVILANGGIFEDARNGVER
                     YWIEVANE"
     gene            700..1290
                     /gene="nrdG"
                     /locus_tag="AC0DU4_002171"
     CDS             700..1290
                     /gene="nrdG"
                     /locus_tag="AC0DU4_002171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001064213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA];
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HIN4238070.1"
                     /translation="MNNPKPQEWKSEELSQGRIIDYKAFNFVDGEGVRNSLYVSGCMF
                     HCEGCYNVATWSFNAGIPYTAELEEQIMADLAQPYVQGLTLLGGEPFLNTGILLPLVK
                     RIRKELPDKDIWSWTGYTWEEMMLETPDKLEFLSLIDILVDGRYDRTKRNLMLQFRGS
                     SNQRIIDVQKSLKSGQVVIWDKLNDGKESYEQVKRE"
BASE COUNT          462 a          249 c          368 g          362 t
ORIGIN      
        1 attagaaaga aatgaaatgg gaaaatatca actagacgat aaggggtgcg cacaagtgac
       61 ccgttatcac gagaaacact ctaaaggtgg agctggtaag aaagaacgct tgcttagctt
      121 cagagaacaa tttttaaaca agaacaagaa aaaataaaag tgagagccag ctctcgcttt
      181 tctcatagtg ggaggtaagg atggaattac gcagaccaag attagcggat aagaaagctg
      241 ttttagatat gatgacagag tttgaaaaat ttcagtcgcc tcacgacggc ggtttctggg
      301 atacagagaa ctttgtgtat gaagactggt tagaaagcaa tcaggaacag gaaatgggga
      361 ttaatctgcc tgaaggatgg gttcctgcaa ttcagttagt ggctttttct gagaaaggtc
      421 aagcagttgg atttcttaat ctccggttgc gcctcagtaa ctttctacta gaagaaggtg
      481 gccacattgg ctactccatt cgtccatctg aaagaggcaa gggttatgca aaagagactc
      541 tccgtcaggg cttgcaagtt gctaaggaaa agaacatcaa gaaagctctg gtgacctgta
      601 gcgtgaataa tcctgctagc agagcagtca ttctagcaaa tggtggaata tttgaggatg
      661 ctcgcaatgg agtcgagcgt tattggatag aggtagcgaa tgaataatcc aaaaccacaa
      721 gaatggaaaa gcgaggaact tagtcaaggt cgtatcattg actacaaggc ctttaacttt
      781 gtggacggcg aaggcgtgcg taactctctc tatgtatcag gctgtatgtt tcactgcgag
      841 ggatgttata atgttgcgac ttggtctttt aatgctggca ttccctatac agcagaatta
      901 gaagagcaga tcatggcaga tcttgctcag ccctatgttc aaggtttgac tttgttggga
      961 ggggagcctt ttcttaatac tgggattctc ttgccacttg ttaagcggat tcggaaggaa
     1021 ttgccagaca aggacatctg gtcctggacc ggctacactt gggaagaaat gatgttggaa
     1081 actccagata aactggaatt cttgtcactg attgacattc ttgtcgatgg aagatatgat
     1141 cgaactaaga gaaatcttat gctccagttt cgaggttcat ctaaccaacg aattatcgat
     1201 gtgcaaaaat cgctcaaaag tgggcaagta gtgatttggg acaagctcaa tgacggaaaa
     1261 gaaagctatg aacaggtgaa gagagaatga agaaaaaatg aagaaaaaag acttagtaga
     1321 ccaactagtc tcagagatcg agacggggaa agtcaggaca ctgggaatat acggtcatgg
     1381 agcttcaggt aaatcaacct ttgcacagga attgtaccaa gctttagatt ctactacagt
     1441 a
//
LOCUS       DBMVGT010000160         1398 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.160, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000160 DBMVGT010000000
VERSION     DBMVGT010000160.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1398)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1398)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1398
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.160"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..559
                     /locus_tag="AC0DU4_002172"
     CDS             <1..559
                     /locus_tag="AC0DU4_002172"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HIN4238071.1"
                     /translation="EVPCEIPESWEWVRLNDITSYIQRGKSPKYSNIPIYPVIAQKCN
                     QWSGFSIDLARFIDPETVHSYQKERLLRDGDLMWNSTGLGTLGRLAIYHENKNPYGWA
                     VADSHVTVIRVLSGVINCHFIYNFLSSPIVQSVIEEKASGSTKQKELLTKTIKEYLIP
                     LPPLPEQSRIVDKIEQFFAHIDALI"
     gene            616..>1398
                     /gene="psrA"
                     /locus_tag="AC0DU4_002173"
     CDS             616..>1398
                     /gene="psrA"
                     /locus_tag="AC0DU4_002173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type DNA invertase PsrA"
                     /protein_id="HIN4238072.1"
                     /translation="MKDFELHLKKAGLAENTVRSYLYGVRFFLENYELKMEDLFEYKG
                     YLLDNFKPKTVNLRLQGVNKYLAFIGHDDLKLKFVKVQQKPFLEDVISHADYLFLKRS
                     LKKDGILKWHFVVWFLGATGARVSELIKLKVEHVEIGYFDIYSKGGKIRRLYIPKKLR
                     NSCLSWLESENRRSGYLFLNKFNEPITARGVAQQLKNYADKYKMNPKVIYPHSFRHLF
                     AKNFLAKYNDIALLADLMGHESIETTRIYLRKTATEQQNIVDK"
BASE COUNT          487 a          201 c          254 g          456 t
ORIGIN      
        1 ggaagtacct tgtgaaatac cagaaagttg ggagtgggtg aggttaaacg atataacctc
       61 ctacattcaa agagggaagt ctccaaaata ttcaaatatt cctatatacc ctgtgattgc
      121 tcagaaatgt aatcaatggt ctggcttttc tattgactta gcaagattta ttgatcccga
      181 aacagttcat agttaccaga aagaaagatt actaagagat ggtgatttaa tgtggaattc
      241 aacaggtcta ggtacgttag gacgattagc tatttaccat gaaaataaaa atccttatgg
      301 ctgggctgtt gcagatagcc atgttacagt tataagagtc ttatcgggag ttattaattg
      361 ccatttcatc tataattttc tttcctctcc tattgttcag tcagttattg aagaaaaagc
      421 gtcgggtagt acaaaacaaa aagaattatt aacgaaaact ataaaagaat atttaatccc
      481 cctcccaccc cttcctgaac aatccagaat cgttgataaa atcgaacaat ttttcgccca
      541 tattgacgca ctaatttagt ataatagttt tacgtgcggt ggaatttcta tcaaacataa
      601 gataggagtt ttacgttgaa agattttgaa ttacatttga agaaagctgg tttagctgaa
      661 aatactgtgc gttcgtacct ttatggtgtt cgatttttct tggagaatta cgaactcaaa
      721 atggaagatt tatttgaata caaaggatat ttattagaca attttaaacc taaaactgtc
      781 aatttgcgac tacaaggagt aaataaatat ctggctttta ttggtcatga tgatttgaaa
      841 ttaaaatttg tcaaagtaca gcaaaaaccg tttttagaag atgtcattag ccatgctgat
      901 tacctttttc ttaaacgtag tttgaaaaaa gatggtattt taaaatggca ttttgtcgtt
      961 tggtttttag gtgcaactgg ggctcgtgta agtgaactta ttaaactaaa agtagagcat
     1021 gtagaaatcg gttattttga catttactca aaaggtggta aaattcgtag actgtacatt
     1081 cctaaaaaat taagaaatag ttgtcttagt tggttagaat cagaaaatcg ccgaagtggt
     1141 tatttatttt tgaataaatt taacgaacca attacagcaa gaggagttgc tcaacagtta
     1201 aaaaattatg ctgataaata caaaatgaat cctaaagtaa tttaccctca ttcttttaga
     1261 catttatttg ctaagaattt tttagcgaag tataatgata ttgccttgct tgcagatttg
     1321 atgggacacg aaagtataga aactactcga atttatctaa ggaaaacagc tactgaacaa
     1381 caaaatattg tagataaa
//
LOCUS       DBMVGT010000161         1385 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.161, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000161 DBMVGT010000000
VERSION     DBMVGT010000161.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1385)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.161"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            75..1361
                     /locus_tag="AC0DU4_002174"
     CDS             75..1361
                     /locus_tag="AC0DU4_002174"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000205044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004019 - adenylosuccinate synthase
                     activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA];
                     GO_process: GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HIN4238073.1"
                     /translation="MTSVVVVGTQWGDEGKGKITDFLSANAEVIARYQGGDNAGHTIV
                     IDGKKFKLHLIPSGIFFPEKISVIGNGMVVNPKSLVKELSYLHEEGVTTDNLRISDRA
                     HVILPYHIELDRLQEEAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFRERL
                     ERNLAEKNRLFEKLYDSKAIVFDDIFEEYYEYGQQIKKYVIDTSVILNDALDNGKRVL
                     FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKIDKVVGVCKAYTSRVGDGP
                     FPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVL
                     SGLDTVKICVAYDLDGQRIDYYPASLEQLKRCKPIYEELPGWSEDITGVRNLEDLPEN
                     ARNYVRRVSELVGVRISTFSVGPGREQTNILESVWS"
BASE COUNT          377 a          211 c          351 g          446 t
ORIGIN      
        1 tgtaagatat aattgcaggt gagagtcctg ccatgtatgt gagaaaggaa gagcctgagg
       61 gctcagacaa gattatgact tcagttgttg ttgtaggtac ccaatggggt gatgaaggta
      121 aagggaagat tacagacttc ctttcagcga atgcagaagt gattgcacgt taccaaggtg
      181 gtgataatgc tggtcacacg attgtgattg acggtaagaa atttaagttg cacttgattc
      241 catctgggat tttcttccct gaaaaaatat ctgtcattgg gaatggtatg gttgtaaatc
      301 ctaaatctct tgtaaaagag ttgagctatc ttcatgagga aggtgtaaca actgataact
      361 tgcgtatttc tgatcgtgcg catgttattt tgccttatca tatcgagttg gatcgcttgc
      421 aagaagaagc taagggcgac aataagattg gtacgacaat taagggaatt ggtccagctt
      481 atatggacaa ggctgctcgt gttggaattc gtattgcaga tcttttagat aaagatattt
      541 tccgtgagcg tttagaacgt aaccttgctg aaaagaatcg tctttttgaa aaattgtatg
      601 acagtaaagc gattgttttc gatgatattt ttgaagaata ttacgaatat ggtcaacaaa
      661 tcaagaaata cgtgatagat acatctgtta tcttgaatga tgcgcttgat aatggcaaac
      721 gtgtgctttt tgaaggtgca caaggtgtta tgctagatat cgaccaaggt acttatccat
      781 ttgttacgtc atcaaaccct gtagctggtg gtgtgacaat tggttctggt gtcggtccaa
      841 gcaagattga caaggttgta ggtgtatgta aagcttatac gagtcgtgta ggagatggtc
      901 ctttcccaac tgagttgttt gatgaagtgg gagaacgtat ccgtgaagtg ggtcatgagt
      961 atggtacaac aactggtcgt ccacgtcgtg taggttggtt tgactcagtt gtgatgcgtc
     1021 atagccgtcg tgtttctggt attactaacc tttctttgaa ctctattgat gttttgagcg
     1081 gtttggatac tgtgaaaatc tgtgtggcct atgatcttga cggtcaacgt attgactact
     1141 atccagctag tcttgagcaa ttgaaacgtt gcaagcctat ctatgaagag ttgccaggtt
     1201 ggtcagaaga tattaccgga gttcgcaatt tggaagatct tcctgagaat gcgcgtaact
     1261 atgttcgtcg tgtgagtgaa ttggttggcg ttcgtatttc tactttctca gtaggtcctg
     1321 gtcgtgaaca aacaaatatt ttagaaagtg tttggtccta agagattttt aagatttgtt
     1381 taaga
//
LOCUS       DBMVGT010000162         1355 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.162, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000162 DBMVGT010000000
VERSION     DBMVGT010000162.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1355)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.162"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            15..>1355
                     /gene="uvrC"
                     /locus_tag="AC0DU4_002175"
     CDS             15..>1355
                     /gene="uvrC"
                     /locus_tag="AC0DU4_002175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009380 - excinuclease repair complex
                     [Evidence IEA];
                     GO_function: GO:0009381 - excinuclease ABC activity
                     [Evidence IEA];
                     GO_process: GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HIN4238074.1"
                     /translation="MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSY
                     FRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEINLIKENKPKYNIMLKDDKSYPFI
                     KITNERYPRLIITRQVKKDGGLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCF
                     YYHIGQCMAHTICKKDETYFKSMAQEVSDFLKGQDNKIIDDLKSKMAVAAQSMEFERA
                     AEYRDLIQAIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNL
                     FPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKALVDSKILKPQRGEKK
                     QLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGT
                     SPVSAMVIFVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPP"
BASE COUNT          402 a          282 c          312 g          359 t
ORIGIN      
        1 gctataatgg aactatgaac aacttgatta aatcaaaact agagctcttg ccgaccagcc
       61 ctggttgcta cattcataag gataaaaatg gcaccattat ctatgtagga aaggctaaaa
      121 atctgcgtaa tcgagtacgg tcctattttc gtggaagtca tgataccaag acagaggctc
      181 tggtgtctga aattgtggat tttgaattta ttgttacgga gtctaatatt gaggcacttc
      241 tcctagaaat caacctgatc aaggaaaaca agcccaagta caatatcatg ctcaaggatg
      301 acaagtccta tcctttcatc aaaatcacca atgagcgcta tccacgcttg attatcactc
      361 gtcaggtcaa aaaggacgga ggtctttatt ttggacccta tcccgatgtg ggggcagcca
      421 atgaaatcaa gcggttgctg gatcggatat tcccttttcg taagtgtacc aacccgccct
      481 ctaaggtctg tttttattac catatcggtc aatgcatggc ccacaccatc tgtaagaagg
      541 atgagactta tttcaagtct atggcccagg aggtttctga ttttctgaaa gggcaggata
      601 acaaaatcat cgatgatctc aagagtaaaa tggcagtagc agcacaaagt atggagtttg
      661 aacgtgcggc ggaataccgt gacctgattc aggctattgg aacgcttcga accaagcaac
      721 gggtcatggc gaaagatttg caaaatcgcg atgtctttgg ctactatgtg gataagggct
      781 ggatgtgtgt gcaggttttc tttgtccgtc agggtaagct tatcgagcgc gatgtcaatc
      841 tcttccccta cttcaatgat ccagatgagg attttttgac ctatgtagga caattctatc
      901 aagaaaaatc tcatctagtt cccaatgagg tactgattcc gcaggatatt gacgaagagg
      961 ctgtcaaggc cttggtggat tccaagattc ttaagcctca acgtggagag aaaaaacaac
     1021 tggtcaatct agccataaaa aatgcacgtg ttagtctgga gcagaaattt aacctgctag
     1081 aaaaatctgt cgaaaagact caaggagcta ttgaaaatct agggcgtttg ctccaaatcc
     1141 cgaccccagt acgtatcgag tccttcgata actctaatat catgggaact agccctgttt
     1201 cggctatggt gatctttgtc aacggtaaac cgagtaagaa ggattaccgt aagtacaaga
     1261 taaaaacggt tgttggacca gacgactatg ccagcatgag agaggtcatt cgcagacgct
     1321 atggtcgagt acagcgtgag gctttgactc ctcca
//
LOCUS       DBMVGT010000163         1338 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.163, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000163 DBMVGT010000000
VERSION     DBMVGT010000163.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1338)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1338)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1338
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.163"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..513)
                     /locus_tag="AC0DU4_002176"
     CDS             complement(<1..513)
                     /locus_tag="AC0DU4_002176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lyase family protein"
                     /protein_id="HIN4238075.1"
                     /translation="MINRYSRPEMANIWSEENKYRAWLEVEILSDEAWAELGEIPKED
                     VALIRKKADFDIDRILEIEQETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAY
                     GYLYKQANDIIRRDLENFTNIIADKAKEHKFTIMMGRTHGVHAEPTTFGLKLATWYSE
                     MKRNIERFEHA"
     gene            complement(576..803)
                     /locus_tag="AC0DU4_002177"
     CDS             complement(576..803)
                     /locus_tag="AC0DU4_002177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazole carboxylase"
                     /protein_id="HIN4238076.1"
                     /translation="MIQIIVNTFIEKDKTGAVVEVLYASADQDKVQAKYEELAAQYPE
                     NYLAIYDVPLDTDLNTLDHYPSVFIGKEEFE"
     gene            complement(813..>1338)
                     /locus_tag="AC0DU4_002178"
     CDS             complement(813..>1338)
                     /locus_tag="AC0DU4_002178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HIN4238077.1"
                     /translation="SGNGKEVTFFPVQENIHRNNILSKTIVPARISESLVDKAKAMAV
                     RIAEQLNLSGTLCVEMFATDDDVIVNEIAPRPHNSGHYSIEACDFSQFDTHILGVLGA
                     PLPVIKLHAPAVMLNVLGQHVEAAEKYVAENPSAHLHMYGKIEAKHNRKMGHVTLFSD
                     VPDSVDELGEGIDF"
BASE COUNT          347 a          326 c          278 g          387 t
ORIGIN      
        1 cgcatgctcg aagcgctcga tattgcgttt catttcgctg taccaagttg ccaatttaag
       61 accaaaggtt gtcggctcag cgtgcacacc atgagtacgc cccatcatga tggtgaactt
      121 gtgctccttg gccttgtcag cgatgatatt agtgaagttt tcaaggtcac gacggatgat
      181 gtcgttggcc tgcttgtaga ggtaaccata agcagtatcc accacgtcgg tagaagttaa
      241 cccatagtga acccacttgc gctcttcacc aagagtctca gaaaccgcac gcgtgaaagc
      301 caccacatcg tggcgcgtct cctgctcaat ttccaaaata cggtcgatgt caaagtccgc
      361 cttcttgcga atcaaagcca catcttcctt agggatttcc cccaactcag cccatgcctc
      421 gtcagagagg atttccacct caagccaagc acggtattta ttttcttcac tccaaatatt
      481 cgccatctca gggcgagagt aacggttgat catgtgttaa tttttccttt cttcttaagc
      541 tgttgggaat aagctatcta ggtaaaccaa gatttctact caaactcctc ttttccaata
      601 aacacagacg ggtaatgatc tagtgtattc aaatccgtat ccagcggtac atcatagata
      661 gctaaataat tttcggggta ttgtgcagct agttcttcat atttagcttg taccttatct
      721 tggtcagcac tggcatacaa cacttcaaca actgctccag tcttatcctt ttcaataaat
      781 gtattaacga taatttgtat catagacttg tcctaaaaat caatcccttc cccaagctca
      841 tccacactat ccggtacatc actaaacaag gtcacatgtc ccatcttacg attatgcttt
      901 gcttctattt taccatacat gtggaggtgg gcgcttggat tttctgcgac atacttttca
      961 gcagcctcga cgtgttgacc taggacattg agcataacgg ctggcgcatg gagtttgatg
     1021 actggtaatg gtgctccgag aacaccgaga atatgggtgt caaactgaga gaaatcacag
     1081 gcttcaatag aatagtgccc agagttatgt ggtcgtgggg cgatttcatt gacaataacg
     1141 tcatcatcag tcgcaaacat ttccacacag agagttccag acaagttgag ttgttctgcg
     1201 attcgcactg ccatagcttt agccttgtct actagacttt cagaaatgcg ggctggtacg
     1261 atggtcttag acaggatatt gttgcggtgg atattttcct gaactgggaa aaacgtcacc
     1321 tccttgccat ttcctgac
//
LOCUS       DBMVGT010000164         1304 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.164, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000164 DBMVGT010000000
VERSION     DBMVGT010000164.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1304)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1304)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.164"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..121
                     /locus_tag="AC0DU4_002179"
     CDS             <1..121
                     /locus_tag="AC0DU4_002179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000153012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HIN4238078.1"
                     /translation="QVVGHPVAPENARPEILELAKTVIGHHKDQSVIAYMEGL"
     gene            121..939
                     /locus_tag="AC0DU4_002180"
     CDS             121..939
                     /locus_tag="AC0DU4_002180"
                     /EC_number="3.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HIN4238079.1"
                     /translation="MADIKLIALDLDGTLLTTDKRLTDRTKATLKAARDRGIKVVLTT
                     GRPLKAMDFFLHELGTDGQEDEYTITFNGGLVQKNTGEILDKTVFSYADVARLYEKTE
                     KLSLPLDAISEGTVYQIQSDQESLYAKFNPALTFVPVDFEDLSSQMTYNKCVTAFAQE
                     PLDAAIQKISPELFDQYEIFKSREMLLEWSPKNVHKATGLAKLISHLGINQSQVMACG
                     DEANDLSMIEWAGLGVAMQNAVPEVKAAANVVTPMTNDEEAVAWAIEEYVLKEN"
     gene            943..>1304
                     /locus_tag="AC0DU4_002181"
     CDS             943..>1304
                     /locus_tag="AC0DU4_002181"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HIN4238080.1"
                     /translation="MGLFDRLFGKKEEPKIEEVVKEALENLDLSEDVDPTFTEVEEVP
                     QEEAEVEIVEQAVFQEEEIQDTVEESQDSEPAVGVSQEEIEELPNSEELPEEEKLEHE
                     GTIEENNSEVLEPERPQT"
BASE COUNT          428 a          238 c          308 g          330 t
ORIGIN      
        1 gcaggttgtg ggacatcctg tagctcctga aaatgcacga ccagagattt tagaattagc
       61 aaagactgtg attggtcacc ataaggacca gtcggttata gcttatatgg agggcttata
      121 atggcagata taaaattaat cgcattggac ttggacggta ccttgctgac tactgataaa
      181 aggctgacgg atcgcaccaa ggcaactttg aaagctgcgc gtgatcgtgg tatcaaggtc
      241 gtattgacaa ctggtcgtcc cttaaaagcc atggacttct ttctccatga gttagggact
      301 gacggtcagg aagatgagta taccattact tttaatggtg gtttggttca gaaaaataca
      361 ggtgaaatcc ttgataaaac agtcttttca tatgctgatg tggcacgctt gtatgagaaa
      421 acagagaaat tatcactgcc acttgatgcc atctcagaag gaacagttta tcaaatccaa
      481 tcggaccaag aaagtcttta tgccaaattc aatccagctt tgacttttgt tccagttgac
      541 tttgaagacc tgtctagtca aatgacctac aacaaatgcg tgactgcctt tgctcaagaa
      601 cccttggatg cagccattca gaagatttct ccagaattgt ttgaccaata tgaaatcttt
      661 aaatcacgtg aaatgttgct agagtggtca ccaaagaatg ttcataaagc aacaggtttg
      721 gcaaaactaa tcagccatct tggaatcaac caaagccaag ttatggcctg tggtgacgag
      781 gccaatgacc tttctatgat tgaatgggca ggtcttggtg ttgctatgca aaacgctgtt
      841 cctgaagtaa aggcagccgc aaatgtagta acgccgatga ccaacgatga ggaagctgtc
      901 gcctgggcta tcgaagaata tgtgctaaag gagaactaag atatgggatt gtttgaccgt
      961 ctattcggaa aaaaagaaga acctaaaatc gaagaagttg taaaagaagc tctggaaaat
     1021 cttgatttgt ctgaagatgt tgatcctacc ttcacagaag ttgaggaagt tcctcaggaa
     1081 gaagcagagg ttgaaattgt tgaacaagct gtgttccaag aggaggaaat ccaagacaca
     1141 gttgaagaaa gtcaggattc agagccagct gtaggggttt ctcaagaaga aatagaagaa
     1201 ttaccaaact cagaagaatt accagaggaa gagaagcttg agcacgaagg aactatagaa
     1261 gaaaataatt ctgaagttct tgaaccagaa aggcctcaaa caga
//
LOCUS       DBMVGT010000165         1294 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.165, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000165 DBMVGT010000000
VERSION     DBMVGT010000165.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1294)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1294)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1294
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.165"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..170)
                     /locus_tag="AC0DU4_002182"
     CDS             complement(<1..170)
                     /locus_tag="AC0DU4_002182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1C family serine protease"
                     /protein_id="HIN4238081.1"
                     /translation="MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNS
                     NNNSTITQTAYK"
     gene            353..832
                     /gene="rlmH"
                     /locus_tag="AC0DU4_002183"
     CDS             353..832
                     /gene="rlmH"
                     /locus_tag="AC0DU4_002183"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695929.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008168 - methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HIN4238082.1"
                     /translation="MKIKVVTVGKLKEKYLKDGIAEYSKRISRFAKFEMIELSDEKTP
                     DKASESENQKILEIEGQRILSKIADRDFVIVLAIEGKTFFSEELSKQLEETSIKGFST
                     LTFIIGGSLGLSSSVKNRANLSVSFGRLTLPHQLMRLVLVEQIYRAFTIQQGFPYHK"
     gene            876..949
                     /locus_tag="AC0DU4_002184"
     tRNA            876..949
                     /locus_tag="AC0DU4_002184"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:910..912,aa:Arg,seq:tct)
     gene            1115..1240
                     /gene="comC"
                     /locus_tag="AC0DU4_002185"
     CDS             1115..1240
                     /gene="comC"
                     /locus_tag="AC0DU4_002185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence-stimulating peptide ComC"
                     /protein_id="HIN4238083.1"
                     /translation="MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK"
BASE COUNT          454 a          160 c          246 g          434 t
ORIGIN      
        1 ttcttatagg cagtttgtgt aatagtacta ttgttgttag agttgtttac actacttttt
       61 tgagttagtt gagttattga aaaactaccc aaggctccac taaaaaagct aatgacgata
      121 acgactaata attgaaacca ttttttgtaa aatgttttta gatgtttcat atttgcctcc
      181 atatgtttga attactgaaa gtataaactg actagcttaa ttataactta aacacaaaag
      241 ttttacacaa actgtggata actcttttga aactgtgatt ttcttaattg aaatctattt
      301 tttattttgt gaataagatg tgaaaaaata gagaatatgt tagaatagag tcatgaaaat
      361 taaagttgta acagttggga aactgaaaga aaagtattta aaagatggta tcgcagagta
      421 ttcaaaacga atttctagat ttgctaagtt tgaaatgatt gagttatcag atgaaaaaac
      481 accagataag gccagtgaat cagaaaatca aaagatttta gaaatagaag gtcagagaat
      541 tttatcaaaa attgctgacc gtgatttcgt tattgtgtta gccattgaag ggaaaacttt
      601 cttctcagaa gaattgagta agcagttaga agaaacttct ataaaaggat tttctactct
      661 tacttttatt attgggggaa gtttaggatt gtcatcatct gtaaaaaata gagccaatct
      721 ttctgtcagt tttggtcgcc taaccttgcc tcatcagtta atgagactag ttcttgttga
      781 acaaatctat cgcgctttta cgattcagca gggattcccc taccataaat agaaaattga
      841 cttttaattg aatttttggt agaataattg tgttaggtct catagctcag ctggatagag
      901 cattcgcctt ctaagcgaac ggtcgcaggt tcgaatcctg ctgggatcaa tataatagca
      961 aagctgggaa ttttcccggc ttttttctta aaaaagtaca ctttgggaga aaaaaatgac
     1021 agttgagaga attttatcta aaacgaaatt ccattttgta taatggtttt tgtaagttag
     1081 cttacaagaa aaaaacattt taggagattt tattatgaaa aacacagtta aattggaaca
     1141 gtttgtagct ttgaaggaaa aagacttaca aaagattaaa ggtggggaga tgaggctgtc
     1201 aaaattcttc cgtgatttta ttttacaaag aaaaaagtaa tgaaataagg ggaaagagta
     1261 atggatttat ttggatttgg gacagttatt gttc
//
LOCUS       DBMVGT010000166         1288 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.166, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000166 DBMVGT010000000
VERSION     DBMVGT010000166.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1288)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1288)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.166"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..806
                     /gene="purM"
                     /locus_tag="AC0DU4_002186"
     CDS             <1..806
                     /gene="purM"
                     /locus_tag="AC0DU4_002186"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004641 -
                     phosphoribosylformylglycinamidine cyclo-ligase activity
                     [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HIN4238084.1"
                     /translation="IKYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYVATGKNEPAK
                     LEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAVGVAEKSQIIDGSKVV
                     EGDVLLGLASSGIHSNGYSLVRRVFADYTGEEVLPELEGKKLKEVLLEPTRIYVKAVL
                     PLIKEELVNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVLPIFKALEKYGQIKHE
                     EMFEIFNMGVGLMLAVSPENVERVKELLDEAVYEIGRIVKKENESVIIK"
     gene            803..>1288
                     /gene="purN"
                     /locus_tag="AC0DU4_002187"
     CDS             803..>1288
                     /gene="purN"
                     /locus_tag="AC0DU4_002187"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004644 - phosphoribosylglycinamide
                     formyltransferase activity [Evidence IEA];
                     GO_process: GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HIN4238085.1"
                     /translation="MKKIAVFASGNGSNFQVIAEEFPVEFVFSDHRDAYVLERAKQLG
                     VLSYAFELKEFESKADYEAALVELLEEHQIDLVCLAGYMKIVGPTLLSAYEGRIVNIH
                     PAYLPEFPGAHGIEDAWNAGVGQSGVTIHWVDSGVDTGQVIKQVRVPRLADDTIDRFE
                     AR"
BASE COUNT          336 a          255 c          352 g          345 t
ORIGIN      
        1 ctatcaagta cgacaagcac gataccatcg ggcaggactg tgtggccatg tgtgtcaacg
       61 acatcattgc tgcaggtgcg gaacccctct attttctcga ctacgtagcg acagggaaga
      121 atgaaccagc taagctagaa caagtggttg ctggtgtggc agaaggttgt gtgcaggctg
      181 gtgctgccct catcggtggg gaaacggctg aaatgccggg catgtacggc gaagacgact
      241 atgacttggc tggttttgcg gtcggtgtgg ctgaaaaatc tcaaatcatt gacggttcaa
      301 aggtggtaga gggagatgtt cttctcggac ttgcttcaag tgggattcac tcaaatggtt
      361 actctttggt tcgtcgtgtc tttgcggatt acacaggtga ggaagtccta ccagaattgg
      421 aaggcaagaa acttaaggaa gttctacttg agccgactcg tatctatgtc aaggctgtct
      481 tgccgctcat caaagaagag ttggtcaacg gcattgccca catcacaggt ggtggcttta
      541 tcgaaaatgt ccctcgtatg tttgcagatg acctagctgc tgaaattgat gaaagcaaag
      601 ttccagtgct tccaattttc aaagcccttg aaaaatatgg tcagattaaa cacgaagaaa
      661 tgtttgaaat cttcaatatg ggtgtgggac ttatgttggc ggtcagccct gaaaatgtag
      721 agcgtgtaaa agaattgttg gatgaagcag tctatgaaat tggtcgcatc gtcaagaaag
      781 aaaacgaaag tgtcattatc aaatgaaaaa aatagcggtt tttgcctctg gtaatggctc
      841 aaattttcag gtgattgccg aagaatttcc agtggagttt gtcttttcag accatcgtga
      901 tgcctatgtg cttgagcgtg caaagcagct cggcgttctg tcctatgctt ttgaactcaa
      961 ggagtttgag agcaaggcag actacgaagc agcccttgtc gaactcttgg aagaacacca
     1021 gattgacttg gtttgcctag caggctacat gaaaatcgtt ggaccaacct tattgtcggc
     1081 ttatgaaggt cggattgtca acattcatcc agcctacttg ccagaatttc caggagctca
     1141 tgggattgag gatgcttgga atgctggcgt gggtcagtct ggtgtgacca ttcactgggt
     1201 ggattcgggt gtggatacag gccaggtcat caaacaggtt cgtgtgccac gactagctga
     1261 tgataccatt gacagatttg aagctcgc
//
LOCUS       DBMVGT010000167         1288 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.167, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000167 DBMVGT010000000
VERSION     DBMVGT010000167.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1288)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1288)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.167"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            156..1288
                     /locus_tag="AC0DU4_002188"
                     /pseudo
     CDS             156..1288
                     /locus_tag="AC0DU4_002188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000472064.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip domain-containing protein"
BASE COUNT          454 a          198 c          233 g          403 t
ORIGIN      
        1 tttttaagcg tttgttactt tcttgcatat ttcctccttg taaataaatt agactatatg
       61 tctaaaaata gattttttat cttgtaattt agatttttta atgtataatc tattatatca
      121 aaattttaga caatatgttt aaaaaaggag aaactatgtt taaagaatgg aaagcaattt
      181 aaaaaaaaca acctttatta ttgtcatgat cgggatttct cttattccag ctctgtacaa
      241 tatcatattt ttgtcatcaa tgtgggatcc atatgggcaa ttgtctgact tatctgtggc
      301 agttgtaaat aatgataaag aggcttccta taatggtaat actatggcaa taggaaaaga
      361 catggtgtcc aatttaaaag aaaataaaac cttggatttt cattttgtag atgaagagga
      421 aggaaagaag ggattggaag atggcgatta ctatatggta gtgactttac caagtgattt
      481 atctaaaaaa acaactacat tatccaatat tcaatcgaca gcagcttatc aatcattgac
      541 aagtgagcaa caaactggga taagtgattc tgtatctcaa aattcaactg atagtattca
      601 atcggctcag tcaattgtag ctttagtaca aggtttacag ggaagtttag aaaacttaca
      661 aaatcaatct tctaatcttt cgactttaaa aaatcaagct aatcaagtat tacctattac
      721 ttctacttct ttgataggat tgtcaagtgg attaacagag atacaaggag ctgttactag
      781 caaattagtt cctgccagtc agttgattgc atcaggtgta aacgcatata ctacaggtgt
      841 tgataaagtt tctcagggcg caagtcaact aagtgaaaaa aatgccacct tgacaggtag
      901 tttggataaa ctagtttcag gctcaaacac cttgacacaa aaatcttcta gattgacagc
      961 aggagttggt taattacaat caggatctgg gcaattagca gacaaatcca gtcagttact
     1021 ttcaggtgct tctccattag agaatagagc taataaattg gcagatggat ctgggaaact
     1081 agcagaaggt ggaacaaagt taacttctgg attggaagat ttacagacag gacttgcttc
     1141 tttaggacaa ggactaggta atgctagtga tcaactcaaa tcagtatcaa cagaatctaa
     1201 aaatgcagag attttgtcaa atccactcaa tctttcaaaa acagacaatg atcaagttcc
     1261 tgtaaatgga atcgcaatag ctccttat
//
LOCUS       DBMVGT010000168         1242 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.168, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000168 DBMVGT010000000
VERSION     DBMVGT010000168.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1242)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1242)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.168"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            35..544
                     /locus_tag="AC0DU4_002189"
     CDS             35..544
                     /locus_tag="AC0DU4_002189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000894002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005576 - extracellular region [Evidence
                     IEA];
                     GO_process: GO:0046677 - response to antibiotic [Evidence
                     IEA];
                     GO_process: GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HIN4238086.1"
                     /translation="MLESKKTTRYVFYVYLMLLTWGILFKFETNPEFIAFFLAPRYIN
                     WIPFSEPLIVDGKIVFAEMLFNLISFIPLGVCFPLIKTNLSSLRIVGTGFLISLLFEC
                     LQYILAIGITDITDLTLNTLGVCVGLLIYQIFIRVFKSQTRKWINILGMLSLGFAYLV
                     LLLLHLIGV"
     gene            569..>1242
                     /locus_tag="AC0DU4_002190"
     CDS             569..>1242
                     /locus_tag="AC0DU4_002190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HIN4238087.1"
                     /translation="MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGV
                     DTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNL
                     YPFKETILKPDATYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAAN
                     GETSYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQPMRYGENP
                     QQDADF"
BASE COUNT          361 a          220 c          262 g          399 t
ORIGIN      
        1 ttgttgaaga cggcttcaaa cggaggtatt tgtaatatta gaatctaaaa aaacaactcg
       61 atatgtattt tatgtctatc tgatgttatt aacttgggga atcttattta agtttgaaac
      121 aaatcctgaa tttatagcat ttttcttagc tccaaggtat atcaattgga ttccattttc
      181 agaaccacta atagtcgatg gaaaaattgt ttttgctgaa atgttattta atctgatttc
      241 ctttattcca ttaggtgttt gtttcccttt gataaaaact aatttatcta gtttaagaat
      301 agtcgggaca ggtttcttga ttagtttatt gtttgagtgc ttacagtata ttttagcaat
      361 aggtataaca gatataacgg atttgacttt aaatacgcta ggtgtctgtg taggcttact
      421 gatttatcaa atttttataa gagtgttcaa atcacagact agaaaatgga tcaatatctt
      481 aggtatgctt agccttggtt ttgcttatct tgttttactg ttactgcatt taattggtgt
      541 ttaactaatg attaaaaagg agaatataat gactaaacgc gtcttaatca gcgtctcaga
      601 caaagcgggc attgttgaat ttgcccaaga actcaaaaaa cttggttggg agattatctc
      661 gacaggtgga actaaggttg cccttgataa tgctggggtg gataccattg ctatcgatga
      721 tgtgactggt ttcccagaaa tgatggacgg tcgtgtgaag accctccacc caaatatcca
      781 cggggggctt ctcgctcgtc gtgacttgga tagccacttg gaagcggcta aggacaacaa
      841 gattgagctc attgaccttg tggtggtcaa cctttaccca tttaaggaaa ctatccttaa
      901 accagatgcg acttatgctg atgcagttga aaatatcgat attggtgggc catctatgct
      961 tcgttcagca gcgaaaaatc atgccagtgt tacagttgtg gtagatcctg ctgactacgc
     1021 tgtggttttg gacgaattgg cagcaaacgg cgaaacctct tatgaaactc gccaacgttt
     1081 agcagccaaa gtatttcgtc acacagcggc ttatgacgcc ttgattgcag aatacttcac
     1141 agctcaagtg ggtgaaagca agcctgaaaa actcactttg acttatgacc tcaagcaacc
     1201 aatgcgttac ggtgagaatc ctcaacaaga cgcggacttt ta
//
LOCUS       DBMVGT010000169         1225 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.169, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000169 DBMVGT010000000
VERSION     DBMVGT010000169.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1225)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.169"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..815
                     /locus_tag="AC0DU4_002191"
     CDS             <1..815
                     /locus_tag="AC0DU4_002191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019314525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_function: GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA];
                     GO_process: GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="DNA polymerase"
                     /protein_id="HIN4238088.1"
                     /translation="QDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAFVPEWEDSVLLS
                     SDYSQIELRVLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDNVTANDRRNAKAV
                     NFGVVYGISDFGLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKGYVETL
                     FKRRRELPDINSRNFNIRGFAERTAINSPIQGSAADILKIAMIQLDKALVAGGYQTKM
                     LLQVHDEIVLEVPKSELVEIKKLVKQTMEEAIQLSVPLIADENEGATWYEAK"
     gene            900..>1225
                     /locus_tag="AC0DU4_002192"
     CDS             900..>1225
                     /locus_tag="AC0DU4_002192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0120225 - coenzyme A binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HIN4238089.1"
                     /translation="MSQEFINPSDGVIRQYLATSKTLAVVGLSDREETTSNRVTKEMQ
                     ARGYKIIPVNPKAAGGEILGEKAYASLAEIPFPVDIVNVYRRSEFLPDVARDFLKADA
                     KIFWAQL"
BASE COUNT          333 a          240 c          313 g          339 t
ORIGIN      
        1 tgcaggattt gacccagacc gggcgtttgt ctagtgtgga tccaaacttg caaaatattc
       61 ctgcccgatt ggaacaaggg cgcttgattc ggaaggcttt tgtgccagag tgggaggata
      121 gtgtgctact cagctctgac tattcacaga ttgaattgcg cgttttggcg catatttcta
      181 aggatgagca cttgattaag gccttccaag agggggcaga tatccatact tcgacagcca
      241 tgcgggtctt tggcattgag cgtcctgata atgtgactgc aaatgaccgt cgcaatgcca
      301 aggcagttaa ctttggagtg gtttatggga tttcagactt tggcttgtct aataatttgg
      361 gaattagtcg taaggaagcc aaagcctaca ttgataccta ctttgaacgt tttccaggta
      421 ttaaaaacta catggatgaa gtggtgcggg aggcgcgtga taagggctat gtagagaccc
      481 tctttaagcg tcgccgtgag ttgccagata tcaattcgcg caacttcaat attcgtggtt
      541 ttgcggagcg aactgctatc aactcaccta tccagggttc ggcagcagat attctcaaga
      601 ttgccatgat tcagctggat aaagccttgg ttgcaggtgg ttatcagact aagatgctgt
      661 tacaagtgca cgatgaaatc gtccttgaag tgcctaaatc tgaattggta gagataaaaa
      721 aattggtgaa acaaaccatg gaagaagcca ttcaactcag tgttcctctt atcgcagatg
      781 agaatgaagg ggcaacctgg tacgaggcta aataaaaagg gggctagtcc tccttttttg
      841 tagtagaatt ctgcaaacct tttcaaaatg tgctatactg atgaaaaagg aggatttcta
      901 tgagtcaaga atttatcaat ccaagtgatg gcgtgattcg tcagtatctc gcaacgagta
      961 aaacccttgc tgtggtgggt ttgtctgacc gtgaagaaac aaccagcaat cgagtaacaa
     1021 aggaaatgca ggctcggggc tataaaatca tcccagtcaa tcccaaggcg gcaggtggcg
     1081 aaatcttggg tgaaaaggct tatgctagcc tcgctgaaat tccttttcct gtagatattg
     1141 tcaatgttta tcgtcgcagt gaatttctgc ccgatgtggc gcgtgatttt ctcaaagctg
     1201 atgccaagat tttttgggca cagct
//
LOCUS       DBMVGT010000170         1204 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.170, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000170 DBMVGT010000000
VERSION     DBMVGT010000170.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1204)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1204)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.170"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>1204
                     /locus_tag="AC0DU4_002193"
     rRNA            <1..>1204
                     /locus_tag="AC0DU4_002193"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          362 a          234 c          355 g          253 t
ORIGIN      
        1 aaggatgtga ggaggaagac gcagtgaact gaaacatcta agtagctgca ggaagagaaa
       61 gcaaaagcga ttgccttagt agcggcgagc gaaacggcag aagggcaaac cgaagagttt
      121 actcttcggg gttgtaggac tgcaatgtgg actcaaagat tatagaagaa tgatttggga
      181 agatcagcca aagagagtaa tagcctcgta tttaaaatag tctttgtacc tagcagtatc
      241 ctgagtacgg cgggacacgt gaaatcccgt cggaatctgg gaggaccatc tcccaaccct
      301 aaatactccc tagtgaccga tagtgaacca gtaccgtgag ggaaaggtga aaagcacccc
      361 gggaggggag tgaaatagaa cctgaaaccg tgtgcctaca acaagttcga gcccgttaat
      421 gggtgagagc gtgccttttg tagaatgaac cggcgagtta cgttatgatg cgaggttaag
      481 ttgaagagac ggagccgtag ggaaaccgag tctgaatagg gcgccttagt atcatgacgt
      541 agacccgaaa ccatgtgacc tacccatgag caggttgaag gtgcggtaag acgcactgga
      601 ggaccgaacc agggcacgtt gaaaagtgct tggatgactt gtgggtagcg gagaaattcc
      661 aaacgaactt ggagatagct ggttctctcc gaaatagctt tagggctagc gtcgacatta
      721 gagattcttg gaggtagagc actgtttggg tgaggggtcc atcccggatt accaatctca
      781 gataaactcc gaatgccaat gaattatggt cggcagtcag actgcgagtg ctaagatccg
      841 tagtcgaaag ggaaacagcc cagaccacca gctaaggtcc caaaataatt gttaagtgga
      901 aaaggatgtg gggttgcaca gacaactagg atgttagctt agaagcagct attcattcaa
      961 agagtgcgta atagctcact agtcgagtga ccctgcgccg aaaatgtacc ggggctaaaa
     1021 caatttaccg aagctgtgga tacctttata ggtatggtag gagagcgttc tatgtgtgat
     1081 gaaggtatac cgtgaggagt gctggaacgc atagaagtga gaatgccggt atgagtagcg
     1141 aaagacaggt gagaatcctg tccaccgtaa gactaaggtt tccaggggaa ggctcgtccg
     1201 ccct
//
LOCUS       DBMVGT010000171         1178 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.171, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000171 DBMVGT010000000
VERSION     DBMVGT010000171.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1178)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.171"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..672)
                     /locus_tag="AC0DU4_002194"
     CDS             complement(<1..672)
                     /locus_tag="AC0DU4_002194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HIN4238090.1"
                     /translation="MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEML
                     AFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQAD
                     KELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVTTGTA
                     LRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTE
                     IQPGDE"
     gene            complement(682..1137)
                     /locus_tag="AC0DU4_002195"
     CDS             complement(682..1137)
                     /locus_tag="AC0DU4_002195"
                     /EC_number="3.6.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016817 - hydrolase activity, acting on
                     acid anhydrides [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0009132 - nucleoside diphosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HIN4238091.1"
                     /translation="MTQQDFRTKVDNTVFGVRATALILQNHKLLVTKDKGKYYTIGGA
                     IQVNESTEDAVVREVKEELGVKAQAGQLAFVVENRFEQDGVSYHNIEFHYLVDLLEDA
                     PLTMQEDEKRQPCEWIDLDKLEDIQLVPAFLKTALPDWEGQLRHIHLEE"
BASE COUNT          301 a          305 c          245 g          327 t
ORIGIN      
        1 ttcgtctcct ggctgaattt ccgtcacatc gtaattgata gaagaagcct tgacacgtgg
       61 aggggttcct gtcttgaaac gaccgatttc gagacccagt tccttgagat tgtcagctag
      121 gttaatagaa gccaagctgt ggttaggacc tgatgagtac ttgaggtctc cgatgataat
      181 ttccccacgg agagcagtcc ctgtcgtcac aataacagcc ttagcagcat attcttgatg
      241 ggtggctgta cgcacaccga caaccttgcc atcttccacc aaaatctcat caatcatggt
      301 ttgacgaagg gtcagatttt cttgattttc aactgtcttg cgcatttcct tagagtaaag
      361 ttccttatca gcctgcgcac gaagggcacg aacggctggg cccttccctg tgttgagcat
      421 cttcatctgg atgtaagtct tgtcaatggt cttggccatc tcgccaccga gggcatcgac
      481 ttcacgtacg acaatcccct tagcagaacc accgatagag ggattacaag gcatgaaagc
      541 cagcatttca atattgatgg tcgcaagcag gaccttacag cccatacggc tagcggccaa
      601 ggaagcctca accccagcgt gtcccgcacc aattacaata atatcgtatt cttcagtaaa
      661 atgataagtc atgtttctct cctattcctc aagatgaatg tgtcttagtt ggccttccca
      721 atctggtagg gccgttttta aaaaggctgg aactagctgg atatcctcaa gcttatccaa
      781 gtcaatccac tcacagggct gccttttctc atcttcctgc atggtcaatg gggcatcctc
      841 aagtaagtcc accagataat gaaactcgat attgtgatag gaaacaccgt cctgttcaaa
      901 acgattttca accacaaaag ctagctgccc agcttgagct ttgacaccca gttcttcctt
      961 cacttcacgg actaccgcgt cttccgtgct ttcattgact tgaatcgcac cgccgatagt
     1021 gtaatacttg cccttgtctt tggtgactag aagcttgtga ttttgaagaa tcaaagctgt
     1081 cgcccgaaca ccaaaaaccg tattgtctac ttttgtccga aagtcttgtt gagtcattct
     1141 tgtcctttcc cttaaacgac acaaaaacag tcaaaact
//
LOCUS       DBMVGT010000172         1164 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.172, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000172 DBMVGT010000000
VERSION     DBMVGT010000172.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1164)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1164)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.172"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(135..371)
                     /gene="comW"
                     /locus_tag="AC0DU4_002196"
     CDS             complement(135..371)
                     /gene="comW"
                     /locus_tag="AC0DU4_002196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma(X)-activator ComW"
                     /protein_id="HIN4238092.1"
                     /translation="MLQKIYEQMANFYDSIEEEYGPTFGDNFDWEHVHFKFLIYYLVR
                     YGIGCRKDFIVYHYRVAYRLYLEKLVMNRGFISC"
     gene            636..1164
                     /locus_tag="AC0DU4_002197"
                     /pseudo
     CDS             636..1164
                     /locus_tag="AC0DU4_002197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558202.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
BASE COUNT          438 a          212 c          152 g          362 t
ORIGIN      
        1 ctttttatca agaagaaaca atagaaagat ttgctatttc caactattaa aaaatgattt
       61 agaaaaatta ctagctattt actatcatct ttccataaaa gagtaaatta gttcggaaat
      121 ttactaaaat tacctcaaca agaaataaaa ccccgattca ttaccaattt ttcaagatac
      181 aaacgataag caacacgata atggtaaaca ataaaatcct tacgacaacc aatgccatat
      241 ctcactaaat aataaattaa aaatttaaaa tgaacatgtt cccagtcaaa attatcacca
      301 aatgtaggac catactcttc ttcaatacta tcatagaaat tagccatctg ctcataaatt
      361 ttttgtaaca taatcaaata ctccttttct tttttataaa cttattctaa caaaaaattt
      421 tacacattca ctatcaattc ctgaattgtt aaaataccag cctcaacaag ataaaaatag
      481 gaaaagttga cagaatagaa acaaatttgc tacctaaatt tcaaacgatt aaagttctaa
      541 aaagaccgcc ttaaaacttt tgggtaaatc ctattagaac tataatattt ttatataggt
      601 attatggttc tgattttcta gtataaaaaa ttcaaactag aattcttctt agaaaaggcc
      661 gttttaagtg ctatcactgt tcaaaaatga gggtcgctga aacttctatc gtcaagaaga
      721 atcatcaaat tccttgtatc atcaaccaaa agattgctca gaagctaatt aaaaagactt
      781 ctatgaccga cattgatcat cagttgtcta tttcaacttc aactgtcatt cgcaagatca
      841 atgattttca ctttgagcat gatttttcgc gtcttcctga gattatgtcc taggacgttg
      901 aaacagtccg gggagtgact gtttcaatcg ggagatggag atgagcttta ttgctcaaga
      961 ctttgataag ctcaatatca taactgttct tgagagcaga acacaagcca tcatccgaaa
     1021 tcccatgaat acaaggctat caagcgatac tgaaagctca ttcaacaaga tagtcagaaa
     1081 ctgagtgata aacgatttta tcgccctact tttcgtatgc acttgactaa taaagaaatt
     1141 ctagataaac ttttgagcta ttcc
//
LOCUS       DBMVGT010000173         1157 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.173, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000173 DBMVGT010000000
VERSION     DBMVGT010000173.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1157)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1157)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.173"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            188..370
                     /gene="rpmF"
                     /locus_tag="AC0DU4_002198"
     CDS             188..370
                     /gene="rpmF"
                     /locus_tag="AC0DU4_002198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015934 - large ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HIN4238093.1"
                     /translation="MAVPARRTSKAKKNKRRTHYKVTAPSVNFDETTGDYSRSHRVSL
                     KGYYKGRKIAKAASAE"
     gene            386..535
                     /gene="rpmG"
                     /locus_tag="AC0DU4_002199"
     CDS             386..535
                     /gene="rpmG"
                     /locus_tag="AC0DU4_002199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001265622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005840 - ribosome [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HIN4238094.1"
                     /translation="MRVNITLEHKESGERLYLTSKNKRNTPDRLQLKKYSPKLRKHVV
                     FTEVK"
     gene            complement(1015..>1157)
                     /locus_tag="AC0DU4_002200"
     CDS             complement(1015..>1157)
                     /locus_tag="AC0DU4_002200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000753868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4238095.1"
                     /translation="NESGSMATGWFTVSGKWYYTYNSGDLLVNTTTPDGYRVNANGEW
                     VG"
BASE COUNT          413 a          215 c          183 g          346 t
ORIGIN      
        1 gaaaccattg acgaaccatt tgagattgat atttaacacc ttctcctgtc tgccgtgtcg
       61 gataggagaa ttttttcatc tttttttgtc aagtaacttt actttacaaa aaaaatgtgt
      121 tatcctagta tggttgatga aaatcagtag attgaatcga atataaatac ctaaaggaga
      181 aatcaaaatg gcagtacctg cacgtcgcac ttcaaaagcg aagaaaaaca aacgtcgtac
      241 acactacaaa gtaacagctc catctgtaaa ctttgacgaa actactggag attactcacg
      301 ttctcaccgt gtatcactta aaggatacta caaaggacgt aaaatcgcta aagctgcatc
      361 agctgaataa tagaagggag ataccatgcg cgtaaatatt acacttgaac acaaagaatc
      421 tggtgaacgc ttgtacctta cttctaaaaa caaacgtaac actccagacc gccttcaatt
      481 gaagaaatac tcaccaaaac ttcgcaaaca cgttgtgttt acagaagtga agtaagcatt
      541 caatacgaat caatacagaa gaaaaacgct tgatcagcgt tttttctttt tgttaatttc
      601 actatattgc aagagaaatc attcgaatga ctacattttt tgaaataaga atacggattc
      661 ggacgattaa aagtaagaga aactcaaatg taagttgggg ttcctttttt gtatattttt
      721 caaataacgc ctctacacta tttgtagcaa attcaccaac tacagttgca tcttagttaa
      781 aataagttag aatatgtaag tgagtaccag atataccaag acatcgtcac catctaaggt
      841 atattcaaaa tacaaaagtt gaccaactag atttctgaat atccttatat atccattctt
      901 aaaattggtt taaatagcgt agtcttttaa actagttttg agaatccaaa aaatcttcct
      961 acatatgtaa gaagattttt tagttcagaa tgattagatt tagctaatgg atacctatcc
     1021 tacccactca ccgttagcat tgactcgata gccatcgggt gtagtcgtgt ttactaataa
     1081 atctcctgaa ttataggtat agtaccattt accagaaact gtaaaccaac cagtagccat
     1141 tgaacctgat tcattta
//
LOCUS       DBMVGT010000174         1149 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.174, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000174 DBMVGT010000000
VERSION     DBMVGT010000174.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1149)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.174"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..1136
                     /locus_tag="AC0DU4_002201"
     rRNA            <1..1136
                     /locus_tag="AC0DU4_002201"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          303 a          247 c          341 g          258 t
ORIGIN      
        1 cccaagcaac tgtttatcaa aaacacagct ctctgctaaa tcgtaagatg atgtataggg
       61 ggtgacgcct gcccggtgct ggaaggttaa gaggagtgct tagcgtaagc gaaggtatga
      121 attgaagccc cagtaaacgg cggccgtaac tataacggtc ctaaggtagc gaaattcctt
      181 gtcgggtaag ttccgacccg cacgaaaggc gtaatgattt gggcactgtc tcaacgagag
      241 actcggtgaa attttagtac ctgtgaagat gcaggttacc cgcgacagga cggaaagacc
      301 ccatggagct ttactgcagt ttgatattga gtgtctgtac cacatgtaca ggataggtag
      361 gagtctaaga gatcgggacg ccagtttcga aggagacgct gttgggatac tacccttgtg
      421 ttatggccac tctaacccag ataggtgatc cctatcggag acagtgtctg acgggcagtt
      481 tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg
      541 ttggaaatca ttcgcagagt gtaaaggtat aagggagctt gactgcgaga gctacaactc
      601 gagcagggac gaaagtcggg cttagtgatc cggtggttcc gtatggaagg gccatcgctc
      661 aacggataaa agctaccctg gggataacag gcttatctcc cccaagagtt cacatcgacg
      721 gggaggtttg gcacctcgat gtcggctcgt cgcatcctgg ggctgtagtc ggtcccaagg
      781 gttgggctgt tcgcccatta aagcggcacg cgagctgggt tcagaacgtc gtgagacagt
      841 tcggtcccta tccgtcgcgg gcgtaggaaa tttgagagga tctgctccta gtacgagagg
      901 accagagtgg acttaccgct ggtgtaccag ttgtcttgcc aaaggcatcg ctgggtagct
      961 atgtagggaa gggataaacg ctgaaagcat ctaagtgtga aacccacctc aagatgagat
     1021 ttcccatgat tatatatcag taagagccct gagagatgat caggtagata ggttagaagt
     1081 ggaagtgtgg cgacacatgt agcggactaa tactaatagc tcgaggactt atccaaagta
     1141 actgagaat
//
LOCUS       DBMVGT010000175         1138 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.175, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000175 DBMVGT010000000
VERSION     DBMVGT010000175.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1138)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1138)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1138
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.175"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..603
                     /locus_tag="AC0DU4_002202"
     CDS             <1..603
                     /locus_tag="AC0DU4_002202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HIN4238096.1"
                     /translation="SYQLPVHLENDANCVGLSELLAHSELENAACVVIGTGIGGAMII
                     NGRLHRGRHGLGGEFGYMTTLAPAEKLNNWSQLASTGNMVRYVIEKSGHTDWDGRKIY
                     QEAAAGNALCQEAIERMNRNLAQGLLNIQYLIDPDVISLGGSISQNPDFIQDVKKAVD
                     NFVDTYEEYTVAPVIQACTYHADANLYGALVNWLQEEKQW"
     gene            597..>1138
                     /locus_tag="AC0DU4_002203"
     CDS             597..>1138
                     /locus_tag="AC0DU4_002203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HIN4238097.1"
                     /translation="MVRFTGLSPKQTQAIEVLKGHISLPDVEVAVTQSDQASISIEGE
                     EGHYQLTYRKPHQLYRALSLLVTVLAEADKVEIEEQAAYEDLAYMVDCSRNAVLNVAS
                     AKQMIEVLALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEAYAQQFDMTF
                     VPCIQTLAHLSAFVKWGVKEV"
BASE COUNT          305 a          257 c          275 g          301 t
ORIGIN      
        1 tcttatcagc tacctgtcca tttagaaaat gatgccaact gcgttggact cagtgaacta
       61 ctagctcatt cagagcttga aaatgcagcc tgtgtcgtga ttgggacagg gattggcgga
      121 gccatgatta tcaatggtag acttcatcga ggtcgccacg gcttgggtgg agaatttggc
      181 tacatgacaa cccttgcccc tgctgaaaaa cttaataact ggtcgcaact agcgtcaact
      241 gggaatatgg tacgatacgt gattgaaaaa tctggtcata ctgattggga cggtcgcaag
      301 atttaccaag aggccgcagc tggtaatgct ctttgtcaag aagccattga gcgcatgaac
      361 cgcaatctgg cgcaaggctt gctcaatatc cagtatctca tcgatccaga tgtcatcagt
      421 ctgggtggct ctatcagtca aaatccagat tttatccaag atgtcaagaa ggctgttgat
      481 aactttgtcg atacctacga agaatacacg gtcgcaccag ttatccaggc ctgcacctat
      541 cacgcagatg ccaatctcta cggtgctctt gtcaactggc tacaggagga aaagcaatgg
      601 taagatttac aggacttagt cccaaacaaa cgcaagctat tgaggtttta aaaggtcaca
      661 tttctctacc agatgtggaa gtggctgtca ctcagtctga ccaagcctct atctctatcg
      721 agggtgagga aggtcactat caattgacct accgcaaacc tcaccaactc tatcgtgcct
      781 tgtccttgtt ggtaacagtt ctagcagaag ctgataaagt agagattgag gaacaagcag
      841 cttacgaaga tttggcttac atggttgact gttctcgaaa tgcggtgctg aatgtggctt
      901 ctgccaagca gatgattgag gtcttggctc tcatgggcta ctcaaccttt gagctttaca
      961 tggaagacac ttaccagatt gaagggcagc cttactttgg ctatttccgt ggagcttatt
     1021 cagcagagga gttgcaggaa atcgaagcct atgctcaaca gtttgacatg acctttgtac
     1081 catgcatcca gaccttggcc cacttgtcgg cctttgtcaa atggggtgtc aaggaagt
//
LOCUS       DBMVGT010000176         1134 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.176, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000176 DBMVGT010000000
VERSION     DBMVGT010000176.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1134)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.176"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>1134
                     /locus_tag="AC0DU4_002204"
     CDS             <1..>1134
                     /locus_tag="AC0DU4_002204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="AIR synthase-related protein"
                     /protein_id="HIN4238098.1"
                     /translation="IDFSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMATIFGR
                     YERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAAT
                     CIGGAIRDPLSGRSYVYQAMRISGAGDITAPISETRAGKLPQQVISKTAAHGYSSYGN
                     QIGLATTYVREYFHPGFVAKRMELGAVVGAAPKGNVVREKPEAGDVIILLGGKTGRDG
                     VGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDFGAGGV
                     CVAIGELADGLEIDLNKVPLKYQGLNGTEIAISESQERMAVVVRPEDVDTFVAECNKE
                     NIDAVVVATVTEKPNLVMHWNGETIVDLERRFLDTNGVRVVVD"
BASE COUNT          296 a          235 c          298 g          305 t
ORIGIN      
        1 acatcgactt ttcagcttct aaatttcaaa agcaattgca gtcaacctat gacaagtata
       61 ttgccatgcg cgaggagtta ggtcggtctg aaaaaccaca aaccttgatg gatatggcga
      121 ctattttcgg tcgttatgag cgtgctaatg gacgattgga tgatatggaa gtctctgacg
      181 aaatcaatgc ctgctcagtt gaaattgaag tggatgttga tggtgtcaag gaaccttggc
      241 tcctcatgtt taaaaatgaa acccacaacc atccaacaga aattgagcca tttggtggag
      301 cggctacctg tatcggtgga gctattcgtg atccgttgtc aggccgttcc tatgtttacc
      361 aagccatgcg tatttcaggt gctggtgata ttacagcacc gatttcggaa actcgtgctg
      421 ggaaattgcc acaacaagtc atttctaaaa cagcagctca tggttattct tcatatggta
      481 accagattgg gcttgccaca acctacgttc gtgaatactt ccacccaggc tttgtagcta
      541 aacgtatgga acttggtgcc gttgttggtg cggctcccaa gggcaatgtt gtccgtgaaa
      601 aacctgaagc aggtgatgtg atcatccttc tcggaggcaa aacaggtcgt gatggtgtcg
      661 gtggtgcgac gggctcttct aaggttcaaa cagttgagtc tgtagagact gctggtgctg
      721 aggttcaaaa aggaaatgcc atcgaagaac gcaagattca gcgcctcttc cgtaatggca
      781 atgtcactcg tctgatcaag aagtccaatg actttggggc aggcggcgtc tgtgtggcta
      841 tcggtgaatt ggcagacggt cttgaaatcg acctcaacaa ggtgcctctt aaataccagg
      901 gcttgaatgg tacagaaatt gccatctctg aatcacaaga acggatggcg gtcgtggttc
      961 gtcctgaaga tgtggatacc ttcgttgccg aatgtaacaa agaaaatatt gatgctgttg
     1021 tggtggcgac agtaactgaa aaaccaaatc ttgtcatgca ctggaatggt gagacaatcg
     1081 ttgacttgga gcgtcgtttc cttgacacca atggtgtgcg cgtggttgtc gatg
//
LOCUS       DBMVGT010000177         1121 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.177, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000177 DBMVGT010000000
VERSION     DBMVGT010000177.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1121)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1121)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.177"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..175
                     /locus_tag="AC0DU4_002205"
     CDS             <1..175
                     /locus_tag="AC0DU4_002205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014621492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="SIS domain protein"
                     /protein_id="HIN4238099.1"
                     /translation="EENVAKDTDDIVLTTVHPYLSPISMVVPTQLVAYFATLHRGLDV
                     DKPRNLAKSVTVE"
     gene            complement(252..389)
                     /locus_tag="AC0DU4_002206"
     CDS             complement(252..389)
                     /locus_tag="AC0DU4_002206"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4238100.1"
                     /translation="MKIKEQTRKLAAGCSKQCFEVVDRTNEVSNHTYGKATLTWFEEI
                     F"
     gene            446..>1121
                     /locus_tag="AC0DU4_002207"
     CDS             446..>1121
                     /locus_tag="AC0DU4_002207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="HIN4238101.1"
                     /translation="MVELGISTFGEITELEGTGQTYSHAERIRQLVAEIELADKVGLD
                     VYGIGEHHRADFAVSAPEIVLAAGAVNTKKIRLTSAVSILSSMDPIRLFQQYATIDAL
                     SDGRSEIMAGRGSFTESFPLFGYDLKDYDSLFDEKLDLLQLVNEKTKLDWQGRLTQTI
                     AGKEVYPRPVQDKLPLWIATGGHVESTVKIAQAGLPIVYAIIGGNPRYFKKLIQAYRE
                     IGSEAGH"
BASE COUNT          305 a          231 c          264 g          321 t
ORIGIN      
        1 agaagagaat gtagccaaag ataccgacga tatcgtcctt acgaccgtac atccatacct
       61 ctcaccaatt tcaatggtcg taccgacgca attagtcgct tactttgcaa ccctccaccg
      121 tggcctcgat gtggacaaac cacgtaacct tgccaagtca gtaacggtag aataagctaa
      181 aaaagtctag ttatctaggc tttttcttgt gagcaaattg gttgcttgta ctcaagattc
      241 gtgttatact cttagaaaat ctcttcaaac cacgtcaacg tcgccttgcc gtaggtatgg
      301 ttactgactt cgttagttct atccacaacc tcaaaacact gttttgagca acctgcggct
      361 agcttcctag tttgctcttt gattttcatt gagtattaga ataatttttc aaattgaagt
      421 acagagatag acaaggagaa tcacaatggt agaattggga atttcaacat ttggggaaat
      481 aacggagctt gaagggactg gacaaactta cagtcatgct gaacgcattc gccagttggt
      541 ggcagagatt gagctggctg acaaggttgg tttggacgta tatgggattg gcgagcacca
      601 tcgggcggat tttgcagtat cagccccaga gattgtcctg gccgctgggg cagtcaatac
      661 caagaaaatc cgtttgacca gtgcagtcag cattctgtca agcatggacc cgattcgttt
      721 gttccaacag tatgccacta tcgatgcttt gtcagatgga cgatcggaga ttatggctgg
      781 aaggggctct ttcacggaat ctttccctct gtttggttat gacttgaaag actacgactc
      841 tctttttgat gagaaattag acttgcttca gttagtcaat gaaaagacca agttagactg
      901 gcaaggtcga ttgactcaaa cgattgctgg taaagaagtt tatcctcgtc cagttcagga
      961 caaattgccc ttgtggatag ctacaggtgg tcatgtcgaa tcaacagtga agattgctca
     1021 ggctggtcta ccgattgtat atgctattat tggtggtaat ccacgttatt ttaaaaagtt
     1081 gattcaggct tatcgtgaga ttggaagcga agcgggccat g
//
LOCUS       DBMVGT010000178         1120 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.178, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000178 DBMVGT010000000
VERSION     DBMVGT010000178.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1120)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1120)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.178"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..463)
                     /locus_tag="AC0DU4_002208"
     CDS             complement(<1..463)
                     /locus_tag="AC0DU4_002208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HIN4238102.1"
                     /translation="MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVAL
                     NPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKAD
                     LAISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQSVNDLAQKKVGA"
     gene            complement(670..>1120)
                     /locus_tag="AC0DU4_002209"
     CDS             complement(670..>1120)
                     /locus_tag="AC0DU4_002209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4238103.1"
                     /translation="NLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLMLALKYVK
                     LSKKDKLKKVEEILERVGLSATLHQKVSELSGGEQQRIAVARAILKPSQLILADEPTG
                     SLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRIIELGEGK"
BASE COUNT          327 a          243 c          191 g          359 t
ORIGIN      
        1 gtgctccgac ctttttctgc gctaagtcgt tgacagactg ataagtggcc aagtcagatt
       61 ttttgacaat gagtttattt tttgcagtat agtagggagt tgaaaaatcg aacaccttgc
      121 tccgttcatc tgtcttagaa acaccagata tggcaagatc ggcttttcct gattgaacac
      181 tagccagtac attgtcaaaa ctcatgggag atagttccaa ttcgacacct agttctgttg
      241 cgatagcttt ggctaattcg atatctgaac ccacaatctg atttttccca tctaccactt
      301 tttgatattc aaatggagca aaatctggat tgagagctac aaccaatttt cctttggact
      361 tgatggcttc aattccagcc gattgattgt tgctacaagc aaatagtagg gggagcatca
      421 ctaaaccaaa catcgtcatc aacaccttct tcatcttatt cataacaaag cctcctttat
      481 gtttattctt tttgcttgta taaataatac tcctatactc atcctttgtc aagtctaaat
      541 tgaaaaaatt ttcaatttga aacaaaaaaa cctagaaata ctacataaaa atgtcatttc
      601 taggcgtatt tatgctattt ctctctggaa aatatgagta ttcagtcagt caaaaggagc
      661 tgaacgaact catttcccct cgcccaattc aatgatccga tgacattgtt gggctacata
      721 agcatcgtgg gtcacaataa tgactgtttt cccctctcga ttcatctcta agagaaactt
      781 caagaccaaa tctctatttt cagggtccag agaacctgtt ggttcatcgg ctaaaatcag
      841 ctggctgggt tttaagatgg ctctagcaac tgcaattcgt tgttgctccc caccagataa
      901 ctcggaaacc ttttggtgca aagtagctga caaacctacc ctctctaaaa tctcttccac
      961 ctttttgagc ttgtctttct tagacaattt cacatatttc agcgccagca taagattgta
     1021 ctcgaccgtt tcatcatcaa tcagggcaaa attttgaaac agataagaga tatgttcacg
     1081 gattattgtt tgcgacttag cagaattaac tgctagattt
//
LOCUS       DBMVGT010000179         1090 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.179, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000179 DBMVGT010000000
VERSION     DBMVGT010000179.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1090)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1090)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.179"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..939
                     /gene="plsX"
                     /locus_tag="AC0DU4_002210"
     CDS             <1..939
                     /gene="plsX"
                     /locus_tag="AC0DU4_002210"
                     /EC_number="2.3.1.274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043811 - phosphate:acyl-[acyl carrier
                     protein] acyltransferase activity [Evidence IEA];
                     GO_process: GO:0008610 - lipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HIN4238104.1"
                     /translation="VEGVNQALSDFSDIEVQLYGDEAKIKQYLTATERVSIIHTDEKI
                     DSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTGALLAAGFFIVGRIKNIDR
                     PGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSFYAKNVRGIAQPRVGLLNN
                     GTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVADVVVADGFTGNAVLKSIE
                     GTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLNYSDVGGAVLFGVKAPVVK
                     THGSSDAKAVYSTIRQIRTMLETEVVAQTAREFSGE"
     gene            945..>1090
                     /locus_tag="AC0DU4_002211"
     CDS             945..>1090
                     /locus_tag="AC0DU4_002211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HIN4238105.1"
                     /translation="MKEKEIFDSIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEF
                     ILTL"
BASE COUNT          301 a          212 c          294 g          283 t
ORIGIN      
        1 gttgagggtg tcaatcaagc cctatctgac ttttcagata tcgaggttca actctacgga
       61 gatgaagcta aaatcaagca atatctgaca gcgacagagc gcgtcagcat tatccatacg
      121 gatgagaaga ttgattcgga tgatgaacct acgagagcta ttcggaataa gaaaaatgcc
      181 agtatggtat tggcagccaa ggctgtcaaa gatggtgaag cagacgctgt cctttcggct
      241 gggaatacag gtgctttgtt ggctgctgga ttcttcatcg tgggtcgtat caagaatatc
      301 gaccgtcctg gacttatgtc aacattgccg actgtagatg ggaaaggttt tgacatgctt
      361 gacctcggtg ctaatgcaga aaatacagcc cagcacctcc atcaatacgc tgtcctaggt
      421 tctttctatg ccaagaatgt tcgtggcatt gcgcaaccac gtgttggttt gctcaacaac
      481 ggaacagaga gtagcaaggg cgacccgctt cgtaaggaaa cttatgaatt actggcggct
      541 gatgaaagtt tgaactttat cggaaacgtg gaagcgcgtg atttgatgaa tggcgttgca
      601 gatgttgttg tggcagatgg tttcacggga aacgctgtgc tcaaatccat cgaagggaca
      661 gctatgggaa tcatgggctt gctcaagaca gctattacag gtggtggtct tcgagcgaaa
      721 ctaggtgccc tccttctcaa ggacagcctc agaggtttga aaaaacagct caattattca
      781 gatgttggtg gagcggtctt gtttggtgtc aaggcacctg ttgtcaagac tcatggctca
      841 agcgatgcca aggctgttta tagtacgatt cgccagattc gtaccatgct agaaacagaa
      901 gtagttgccc agactgcgcg tgaattttca ggagaataaa agagatgaaa gaaaaagaaa
      961 tttttgacag tattgtgacc attatccaag agcgacaggg agaggacttt gtcgtgacag
     1021 aatccttgag tctgaaagac gacttggatg ctgactcagt tgatttgatg gagtttatct
     1081 tgacgctgga
//
LOCUS       DBMVGT010000180         1061 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.180, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000180 DBMVGT010000000
VERSION     DBMVGT010000180.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1061)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.180"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>1061
                     /locus_tag="AC0DU4_002212"
     CDS             <1..>1061
                     /locus_tag="AC0DU4_002212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_process: GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 3"
                     /protein_id="HIN4238106.1"
                     /translation="KKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILGIASY
                     PMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDDIELL
                     NEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLEIFLKFAPEPHGHKKTDGEIVDP
                     YDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNVTQFM
                     AESRENVTNAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVSAKNV
                     MKQKSFHKGIEQLVQEGAVQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAEVVMS
                     PMGKKTVRWIKPEDLDERMS"
BASE COUNT          291 a          204 c          268 g          298 t
ORIGIN      
        1 aagaaattgt ttgaggttgt gaaacatcgt ggcattccag tctttacctt tatgaacaag
       61 ttggatcgtg acggtcgtga gcctttggat ctcttgcaag aattggaaga aatcttgggc
      121 attgctagct accctatgaa ctggcctatc gggatgggga aagcctttga gggcttgtat
      181 gacctctata accaacgttt agagctttac aaaggggatg agcgttttgc tagcctagaa
      241 gatggagaca aactttttgg tagcaatcct ttctacgagc aagtcaagga tgacattgag
      301 cttttaaatg aagctgggaa tgagttttca gaggaagcta ttctggctgg agaattgacg
      361 cctgtctttt tcggttcagc cctgacaaac tttggtgtgc agaccttcct tgaaatcttc
      421 ctcaagtttg ctccagaacc acatggtcac aagaaaacag acggtgaaat tgtggatcct
      481 tatgacaagg atttctcagg ctttgtcttt aaaatccaag ccaacatgga tcctcgtcac
      541 cgtgaccgta ttgcctttgt ccgtatcgta tcaggcgaat ttgagcgtgg catgagtgtc
      601 aatctccctc gtactggtaa gggtgccaaa ctatctaatg ttacccagtt tatggcggag
      661 agtcgtgaga atgtgaccaa tgccgtagca ggtgatatta tcggggttta cgataccggt
      721 acttatcagg ttggggatac cttgacggtt ggaaaaaaca agtttgaatt tgaaccactg
      781 ccaaccttta ctcctgaaat tttcatgaaa gtttctgcta agaatgttat gaagcaaaaa
      841 tccttccaca aggggattga gcaattggtg caagaaggag ccgttcagct ttataagaat
      901 taccaaacag gtgagtacat gctgggagct gttggtcaac tccagtttga agtctttaaa
      961 caccgtatgg aaggcgaata caatgcggaa gtggtcatga gcccaatggg taaaaagacc
     1021 gttcgttgga tcaagcctga ggacttggat gaacggatgt c
//
LOCUS       DBMVGT010000181         1050 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.181, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000181 DBMVGT010000000
VERSION     DBMVGT010000181.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1050)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1050)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.181"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..480
                     /gene="rmuC"
                     /locus_tag="AC0DU4_002213"
     CDS             <1..480
                     /gene="rmuC"
                     /locus_tag="AC0DU4_002213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombination protein RmuC"
                     /protein_id="HIN4238107.1"
                     /translation="LLASVKRFARDIRNKYIAPPRTTNFGVLFVPTEGLYSEIVRNPV
                     FFDDLRREEQIIVAGPSTLSALLNSLSVGFKTLNIQKSADHISKTLASVKTEFGKFGG
                     ILVKAQKHLQHASGNIDELLNRRTIAIERTLRHIELSEGEPALDLLHFQENEEEYED"
     gene            470..>1050
                     /locus_tag="AC0DU4_002214"
     CDS             470..>1050
                     /locus_tag="AC0DU4_002214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260511.1"
                     /note="catalyzes the exonucleic cleavage of mRNA yielding
                     nucleioside 5'-phosphates; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HIN4238108.1"
                     /translation="MKISHMKKDELFEGFYLIKSADLRQTRAGKNYLAFTFQDDSGEI
                     DGKLWDAQPHNIEAFTAGKVVHMKGRREVYNNTPQVNQITLRLPQAGEPNDPADFKVK
                     SPVDVKEIRDYMSQMIFKIENPVWQRIVRNLYTKYDKEFYSYPAAKTNHHAFETGLAY
                     HTATMVRLADAISEVYPQLNKSLLYAGIMLHDLA"
BASE COUNT          304 a          246 c          228 g          272 t
ORIGIN      
        1 ctcctagcaa gtgtcaagcg ttttgctagg gatattagga acaagtacat agcaccacct
       61 cggacgacca attttggagt tttgtttgtt ccgacagaag gtctctactc agaaatcgtc
      121 cgcaatccgg tcttctttga tgatttgaga cgggaagaac agattattgt tgcaggacca
      181 agtaccctat cagcccttct taactcccta tcagttggtt tcaagaccct taatatccaa
      241 aagagtgccg accatatcag caagactctt gccagtgtca agaccgagtt tggcaagttt
      301 ggtggtattc tggtcaaggc acaaaaacat ctccaacatg cctctggcaa tattgatgaa
      361 ttattaaacc gtcgtaccat agctatcgag cggacgctcc gtcacattga gttgtcagaa
      421 ggcgagcctg cgcttgatct actccatttt caagaaaatg aggaagaata tgaagattag
      481 tcacatgaaa aaagatgagc tatttgaagg cttttaccta atcaaatcag ctgacctgag
      541 gcaaactcga gctgggaaaa actacctagc ctttaccttc caagatgata gtggcgagat
      601 tgatgggaag ctctgggatg cccaacctca taacattgag gcctttaccg caggtaaggt
      661 tgtccacatg aaaggacgcc gagaagttta taacaatacc cctcaagtca atcaaattac
      721 tctccgcctg cctcaagctg gtgaacccaa tgacccagcc gatttcaagg tcaagtcacc
      781 agttgatgtc aaggaaattc gtgactacat gtcgcaaatg attttcaaaa ttgaaaatcc
      841 tgtctggcaa cggattgtcc gaaatctcta caccaagtat gataaggaat tctactccta
      901 tccagctgcc aagaccaacc accatgcctt tgaaacgggg ttggcttatc atacggcgac
      961 catggtacgt ttggcagacg ctattagcga agtttatcct cagctcaata agagtctgct
     1021 ctatgcgggg attatgttgc acgacttggc
//
LOCUS       DBMVGT010000182         1047 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.182, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000182 DBMVGT010000000
VERSION     DBMVGT010000182.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1047)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.182"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..138
                     /locus_tag="AC0DU4_002215"
     CDS             <1..138
                     /locus_tag="AC0DU4_002215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase"
                     /protein_id="HIN4238109.1"
                     /translation="LAGQGQLTVDGKNYPIQKGSHFILPSDVEAWTLEGQGLELIVSH
                     P"
     gene            complement(159..>1047)
                     /locus_tag="AC0DU4_002216"
     CDS             complement(159..>1047)
                     /locus_tag="AC0DU4_002216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001821651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005886 - plasma membrane [Evidence IEA];
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="sodium-dependent transporter"
                     /protein_id="HIN4238110.1"
                     /translation="FIVSRGVQKGIERASKVMMPLLFIIFVVIIGHSLSLSNAMEGVL
                     YFLKPDFSKLTSADLLYALGQSFFALSLGVTVMLTYASYLDKKTNLVQSGISIVAMNI
                     SISIMAGLAIFPAMSAFNIQSEGGPSLLFIVLPQLFDKMPFGTIFYVLFLFATVTSSV
                     VMLEINVGNVTNQDNSKRAKWSVILGILTFVFGIPSALSYGVMADVHIFGKTFFDAMD
                     FLVSNLLMPFGALYLSLFTGYIFKKALAMEELHLDERAWKQGLFQVWLFLLRFFVSSF
                     QSSSLWSSLPNLCNQKELE"
BASE COUNT          346 a          197 c          259 g          245 t
ORIGIN      
        1 ttagctggtc aaggtcagct aactgttgac gggaaaaatt atccaattca aaaaggcagc
       61 cactttatcc taccaagtga tgttgaagct tggactctgg aagggcaagg tttggaattg
      121 attgttagcc atccataaaa agaaagggcc tgagttcact actcaagttc tttttgatta
      181 cataaattgg gcaatgaaga ccacaatgat gatgattgga atgacgaaac gaagaaacga
      241 agaaggaaga gccagacttg gaacagtcct tgtttccatg ctctttcatc gagatggagt
      301 tcctccattg caagagcctt tttaaagata tagcctgtaa aaagtgaaag gtagagagct
      361 ccaaatggca tgaggagatt ggaaaccaag aagtccatag cgtcaaagaa ggtcttacca
      421 aaaatgtgaa catccgccat gacaccgtaa gatagggctg aaggaatgcc aaagacaaag
      481 gtcaaaattc ctaaaataac actccatttg gcacgtttgc tgttatcctg gttggtgaca
      541 ttgcccacat tgatctccag catcacgaca gaagaagtga cagtcgcaaa gaggaagagg
      601 acgtagaaaa tggttccaaa aggcatcttg tcaaagagtt gaggcaagac gataaagagc
      661 aggctgggtc ccccttcaga ctggatattg aaggctgaca tggctgggaa aatggctaga
      721 cctgccatga tggatatcga gatattcatg gctacgatgg agattcctga ctggactaga
      781 ttggttttct tgtccaagta agaagcatag gtcaacatga ctgtaacccc tagtgagagg
      841 gcaaagaaag attgtcccag agcatagagg agatcagcgc tagtcagttt tgaaaagtct
      901 ggtttgagga agtaaagaac cccttccatg gcatttgaca agctgagaga gtgaccgatg
      961 ataacaacaa agatgataaa gagcaggggc atcatgactt tcgaagctct ttcaatccct
     1021 ttttgaaccc cacgtgatac aatgaag
//
LOCUS       DBMVGT010000183         1042 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.183, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000183 DBMVGT010000000
VERSION     DBMVGT010000183.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1042)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.183"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>1042
                     /locus_tag="AC0DU4_002217"
     CDS             <1..>1042
                     /locus_tag="AC0DU4_002217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HIN4238111.1"
                     /translation="NSLISVVKVNGKKIYLGGDLDNVHGAEDKYGPLIGKVDLMKFNH
                     HLDTKNSNTKNFIKNLSPEIIVQTSSSPIGSYDSGQEINREYISWLESMGIQHINAAS
                     KDYDATVFDIRQDGLVNISTSYKPIPSFQAGWHKSSYGNWWYQAPDSTGEYAVGWNEI
                     KGEWYYFNQTGILLQNQWKKWNNRWFYLTDSGVAAKNWKKIAGIWYYFNKENQMEIGW
                     IQDKEQWYYLDVDGSMKTGWLQYKGQWYYFAPSGEMKTGWVKDKEAWYYMDSTGIMKT
                     GEIEVAGHHYYLEESGAMKQGWLKKANDWYFYKTDGSRAIGWIKDKDKWYFLKENGQL
                     LVNGKTPEGYTVD"
BASE COUNT          360 a          142 c          239 g          301 t
ORIGIN      
        1 aattccttga ttagtgtggt aaaagtcaat ggcaagaaaa tttaccttgg gggcgactta
       61 gataatgttc atggagcaga agacaagtat ggtcctctca ttggaaaagt tgatttgatg
      121 aagtttaatc atcatttaga tacaaaaaat tctaatacaa aaaattttat aaaaaatttg
      181 tctcctgaga taattgttca aacttcctcc tcaccaattg gttcgtatga tagcggtcaa
      241 gaaataaata gggaatatat tagttggctt gaatcaatgg gaattcaaca tataaatgca
      301 gccagcaaag actatgatgc aacagttttt gatattcgac aagacggttt agtaaacatt
      361 tcaacttcct acaagccgat tccaagtttt caagctggtt ggcataagag ttcatatgga
      421 aactggtggt atcaagcgcc tgattctaca ggagaatatg ctgtcggttg gaatgaaatt
      481 aagggtgaat ggtattactt taaccaaacg ggtatcttat tacagaatca atggaaaaaa
      541 tggaacaatc gttggttcta tttgacagac tctggtgttg ctgctaaaaa ttggaagaaa
      601 atcgctggaa tctggtatta ttttaacaaa gaaaaccaga tggaaattgg ttggattcaa
      661 gataaagagc agtggtatta tttggatgtt gatggctcta tgaagacagg ttggcttcaa
      721 tataaggggc aatggtatta ctttgctcca tcaggggaaa tgaaaacggg ctgggtaaaa
      781 gataaagaag cctggtacta tatggattct actggtatca tgaagacagg tgagatagaa
      841 gttgctggac atcattacta tctagaagaa tcaggagcta tgaagcaagg ctggcttaaa
      901 aaggcaaatg attggtattt ctacaagaca gatggttcac gagctatagg ttggattaaa
      961 gacaaggata aatggtactt cttgaaagaa aatggtcaat tacttgtgaa tggtaagaca
     1021 ccagaaggct atactgtgga tt
//
LOCUS       DBMVGT010000184         1041 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.184, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000184 DBMVGT010000000
VERSION     DBMVGT010000184.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1041)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1041)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1041
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.184"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..550
                     /locus_tag="AC0DU4_002218"
     CDS             <1..550
                     /locus_tag="AC0DU4_002218"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HIN4238112.1"
                     /translation="ETTSYPIYEIPKAWRYIKFASLVNFRIGKTPPRSEATFWGTEIP
                     WVSISDMPISGYVTNTRESISKLALKSKKIDISPKGTLLMSFKLSIGKVAILDIPATH
                     NEAIISIFPYANKENIIRDYLMIFLPLISTLGDSKDAIKGKTLNSTSISELLIPISNH
                     EEMKRIISKVDLLFQKVSQLFE"
     gene            complement(498..>1041)
                     /locus_tag="AC0DU4_002219"
     CDS             complement(498..>1041)
                     /locus_tag="AC0DU4_002219"
                     /EC_number="3.1.21.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HIN4238113.1"
                     /translation="MNWVVIKIKDIFSINTGLSYKKGDLSINKGVRIIRGGNIKPLEF
                     SLLDNDYYIDTQFISSEQVYLKHNQLITPVSTSLEHIGKFARIDKDYDGVVAGGFIFQ
                     LTPFESSEIISKFLLFNLSSPLFYKQLKAITKLSGQALYNIPKTTLSELLIPLAPFEE
                     QELITQKVEKLFEKVNQLWK"
BASE COUNT          373 a          167 c          150 g          351 t
ORIGIN      
        1 cgaaacaacc tcttatccta tatatgaaat cccaaaagca tggagatata ttaaatttgc
       61 tagcctagtt aacttcagaa taggaaaaac tcctccacgc agtgaagcta ctttttgggg
      121 aactgaaata ccctgggtat ctatatcaga tatgcctata tctggttatg taactaatac
      181 gagagaatct atttctaaat tagcattaaa atcaaagaaa atagacattt cacctaaagg
      241 aactttatta atgagtttta aattatctat tggaaaagtt gccatattgg atattcctgc
      301 cactcataat gaagccatta tatcgatatt cccctatgct aataaagaaa atattatcag
      361 agattactta atgatatttt tgccacttat ctctacttta ggtgattcaa aagatgctat
      421 caaagggaaa acattaaata gtaccagtat ctccgaatta ttaatcccta tttctaatca
      481 tgaagagatg aaaagaatca tttccaaagt tgatttactt tttcaaaaag tttctcaact
      541 ttttgagtaa taagttcctg ttcctcaaaa ggagctaacg gaattaatag ctcgcttagt
      601 gtagttttag gaatattata taaagcttga cctgatagtt tagttattgc tttcaattgt
      661 ttataaaata acggagagga caagttaaat aatagaaatt ttgaaataat ctctgaactt
      721 tcgaatggtg ttaattggaa aataaatcca ccagccacaa caccatcata gtctttatcg
      781 attcttgcaa actttccaat atgttctaaa gaggttgata caggtgttat tagctgatta
      841 tgttttaaat aaacttgctc agaggagatg aattgtgtgt caatgtagta atcattatcc
      901 aacagagaaa attctaaagg cttaatatta ccaccacgta taattctaac acctttatta
      961 atgcttaaat cgcccttctt gtaagaaaga cctgtattta ttgaaaaaat atcttttatt
     1021 tttataacaa cccaattcat a
//
LOCUS       DBMVGT010000185         1038 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.185, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000185 DBMVGT010000000
VERSION     DBMVGT010000185.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1038)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.185"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>1038
                     /locus_tag="AC0DU4_002220"
     CDS             <1..>1038
                     /locus_tag="AC0DU4_002220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004803 - transposase activity [Evidence
                     IEA];
                     GO_process: GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element IS1167A family transposase"
                     /protein_id="HIN4238114.1"
                     /translation="RILLRKRRFKCYHCSKMMVAETPLVKKNHQIPRIINQKIAQKLI
                     EKISMTDIAHQLAISTSTVIRKLNDFHFEHDFSRLPKIMSWDEYAFTKGKMSFIAQDF
                     DNLNIITVLEGRTQAVIRNHFLRYDRAVRCQVKIITMDMFSPYYDLAKQLFPCAKIVL
                     DRFHIIQHLSRAMSRFRVQIMNQFERKSHEYKAIKRYWKLIQQDSRKLSDKRFYRPTF
                     RIHLTNKEILDKILSYSEDLKHHYQIYQLLLFHFQNKDPEKFFGLIEDNLKQVHPIFQ
                     TVFKTFLKNKEKIVNALQLPYSNAKLEATNNLIKLIKRNAFGFRNFENFKKRIFIALN
                     IKKERTKFVLSQ"
BASE COUNT          340 a          218 c          161 g          319 t
ORIGIN      
        1 agaattctcc ttagaaaacg ccgtttcaag tgctatcact gttcaaaaat gatggttgct
       61 gagactcccc tggtaaagaa aaatcaccaa atccctcgta tcatcaacca aaaaattgct
      121 caaaagttaa ttgaaaaaat ttctatgact gatattgccc atcagctggc catttcaact
      181 tcaactgtca ttcgcaagct caatgacttt cactttgagc atgatttttc tcggcttcca
      241 aagattatgt cttgggatga gtatgccttc actaagggaa agatgagttt cattgcgcaa
      301 gattttgata atcttaatat tatcactgtt cttgaaggca gaacacaagc tgtcatccga
      361 aatcactttc ttcgctacga tagagccgtt cgttgtcaag tgaaaatcat tacgatggat
      421 atgtttagtc cttactatga cttggctaaa cagctttttc cgtgtgctaa aatcgttcta
      481 gatcgtttcc atattatcca acatctcagc cgtgccatga gtcgttttcg tgttcaaatt
      541 atgaatcagt ttgaacgaaa atctcatgaa tacaaggcta tcaagcgtta ctggaaactc
      601 atccaacagg atagtcgtaa actcagcgat aaacgttttt atcgccctac ttttcgcata
      661 cacttaacaa ataaagaaat tcttgacaag attttaagct attcagaaga cttgaaacac
      721 cactatcaga tctatcaact cttacttttt cactttcaga acaaagaccc tgagaaattt
      781 ttcggactca ttgaggacaa tctgaagcag gttcatccta tttttcagac tgtctttaaa
      841 acctttctaa agaacaaaga aaaaatcgtc aatgctcttc aattacctta ttccaatgca
      901 aaattggaag cgaccaataa tctcatcaaa cttatcaaac gaaacgcctt tggatttcgg
      961 aactttgaaa acttcaaaaa aaggattttt atcgctctga acatcaaaaa agaaaggacg
     1021 aaatttgtcc tttctcaa
//
LOCUS       DBMVGT010000186         1036 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.186, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000186 DBMVGT010000000
VERSION     DBMVGT010000186.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1036)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1036)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.186"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>1036
                     /gene="spuA"
                     /locus_tag="AC0DU4_002221"
     CDS             <1..>1036
                     /gene="spuA"
                     /locus_tag="AC0DU4_002221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="LPXTG-anchored pullulanase SpuA"
                     /protein_id="HIN4238115.1"
                     /translation="FEDLEPNYYHFMDADGTPRTSFGGGRLGTTHHMTKRLLVDSIKY
                     LVDTYKVDGFRFDMMGDHDAASIEEAYKAARALNPNLIMLGEGWRTYAGDENMPTKAA
                     DQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPAFITGGKRDINTIFKNLIAQPTNFEA
                     DSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKAENYAEIHRRLRLGNLMVLTAQGTPF
                     IHSGQEYGRTKQFRDPAYRTPVAEDKVPNKSHLLRDKDGNPFDYPYFIHDSYDSSDAV
                     NKFDWTKATDGKAYPENVKSRDYMKGLIALRQSTDAFRLKSLQDIKDRVHLITVPGQN
                     GVEKEDVVIG"
BASE COUNT          305 a          255 c          214 g          262 t
ORIGIN      
        1 tctttgaaga tttggaacca aactactacc actttatgga tgccgatggc acacctcgaa
       61 ctagctttgg tggtggacgt ttggggacaa cccaccatat gaccaaacgg ctcctagttg
      121 actctatcaa atatctagtt gatacctaca aagtggatgg cttccgcttc gatatgatgg
      181 gagaccatga tgcggcttct atcgaagaag cttacaaggc tgcacgcgcc ctcaatccaa
      241 acctcatcat gctgggtgaa ggttggagaa cctatgctgg tgatgaaaat atgcctacta
      301 aggctgctga ccaagattgg atgaaacata ccgatactgt tgctgtcttc tcagatgaca
      361 tccgtaacaa cctcaagtct ggttatccaa acgaaggtca acctgccttt atcacaggtg
      421 gcaagcgtga tatcaacact atcttcaaaa acctcattgc tcaaccaacc aactttgaag
      481 cagacagtcc tggagatgtc atccaataca tcgcagccca tgataacttg accctctttg
      541 acatcattgc ccagtctatc aaaaaagacc caagcaaagc tgagaactat gctgaaatcc
      601 accgtcgttt acgacttgga aatctcatgg tcttgacagc tcaaggaact ccgtttatcc
      661 actctggcca ggaatatgga cgtaccaaac aattccgtga cccagcctac agaactcctg
      721 tagcagagga taaggttcca aacaaatctc acttgttgcg tgataaggac ggcaacccat
      781 ttgactatcc ttacttcatc catgactctt acgattctag tgatgcagtc aacaagtttg
      841 actggactaa ggctacagat ggtaaagctt atcctgaaaa tgtcaagagc cgtgactata
      901 tgaaaggttt gattgccctt cgtcaatcta cagatgcctt ccgacttaag agtcttcaag
      961 atatcaaaga ccgtgtccac ctcatcactg tcccaggcca aaatggtgtg gaaaaagagg
     1021 atgtagtgat tggcta
//
LOCUS       DBMVGT010000187         1008 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.187, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000187 DBMVGT010000000
VERSION     DBMVGT010000187.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 1008)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1008)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.187"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..69)
                     /locus_tag="AC0DU4_002222"
                     /pseudo
     CDS             complement(1..69)
                     /locus_tag="AC0DU4_002222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
     gene            complement(304..615)
                     /locus_tag="AC0DU4_002223"
     CDS             complement(304..615)
                     /locus_tag="AC0DU4_002223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="CHY zinc finger protein"
                     /protein_id="HIN4238116.1"
                     /translation="MIEAQGFLVDKQTRCIHYHSKLDIIALQCYDCKKYYACYRCHDS
                     LENHPFEPYPLSLIQDKPILCGVCLKLLTYKQYKESLSCPFCFSRFNPGCQNHKERYF
                     K"
     gene            complement(630..>1008)
                     /locus_tag="AC0DU4_002224"
     CDS             complement(630..>1008)
                     /locus_tag="AC0DU4_002224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="U32 family peptidase C-terminal
                     domain-containing protein"
                     /protein_id="HIN4238117.1"
                     /translation="TGFYYGTPSENEQLFGARRKIPEYKFVAEVVSYDDAAQTATIRQ
                     RNVINEGDQVEFYGPGFRHFETYIEDLHDAKGNKIDRAPNPMELLTIKVPQPVQSGDM
                     VRALKEGLINLYKEDGTSVTVRA"
BASE COUNT          315 a          196 c          173 g          324 t
ORIGIN      
        1 catatcgtaa aggtcgtatt tccaacggca tgactgagaa catccaccac ggttggcatc
       61 acgcatactc tagacgcaat tctaatcttt tagactttgc ataataactg ttaaacagtt
      121 gaaaattaac ccagttttaa caagtagtca aaataccaga taaaggaaaa aagtctttaa
      181 aatcttaaaa acgcatagta tcaggtattg aacaatcttg atattatgcg ttttattgtg
      241 ggaagattta cttcattttc tcttggaatt gagttttctc ctacttcaaa actagatgat
      301 ttgctattta aaatagcgtt ccttatgatt ttggcaacct ggattaaagc gagaaaaaca
      361 aaaggggcaa cttaagcttt ctttatattg cttatatgtt agtagtttta gacaaacacc
      421 acataaaata ggcttatcct gtatcaaaga taagggatac ggctcaaaag ggtgattttc
      481 taatgaatca tgacaccgat aacaagcata atacttttta caatcatagc attgtaaagc
      541 aataatatcc agcttgctat ggtaatgaat gcatcttgtt tgcttatcca ctaagaaacc
      601 ctgtgcctct atcatttcct tttcctttct taagctcgaa ctgtgacgct ggttccatct
      661 tccttataaa gattgatgag tccttctttt aatgcacgaa ccatgtctcc tgattgaacg
      721 ggttgaggca ccttaatagt caatagttcc attggatttg gagcgcggtc gattttattg
      781 cctttggcat catgcaaatc ttcaatatag gtttcaaaat gacggaaacc tggaccataa
      841 aactcaactt ggtccccttc gttaatgaca tttcgttgac gaattgttgc tgtttgtgcc
      901 gcatcatcat aagaaaccac ttcagcgaca aacttgtact caggaatttt acggcgagca
      961 ccaaacaact gctcattttc agatggtgta ccatagtaaa atcctgta
//
LOCUS       DBMVGT010000188          985 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.188, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000188 DBMVGT010000000
VERSION     DBMVGT010000188.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 985)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 985)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..985
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.188"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..985)
                     /locus_tag="AC0DU4_002225"
                     /pseudo
     CDS             complement(1..985)
                     /locus_tag="AC0DU4_002225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_050084071.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family transposase"
BASE COUNT          269 a          233 c          195 g          288 t
ORIGIN      
        1 agctcttgct ttagctcctt caaaactttg agaaaaaacc accctcgctt ttttaaactg
       61 agcttaggct aaaagagtcc agtggactct tttactccgt cccataacca atgatttaat
      121 ggcgcgttca gctagattat tggaaaggac cagatgtccg tcttttaaaa tggtcttaaa
      181 ggtttcttca tacttgaggc tgtattcaat tgcccttcct ggttttgaac ctgctaaaac
      241 tgactgacgg cggcaccaag caaagaagtc ttccattaag ggctggacgt ttctgtagtc
      301 gttcatcagc tggcaaagcc tcccagtctc tttccaaggc aaataactgg tcacgatagg
      361 ctaaaccttt agctcctaag gatgatttat ctgcttgctt gggggtcgct tcaaaaaatt
      421 tccttctcac atgcgcccaa catccaacaa gttcagcttc ttccagttga cgataagctt
      481 ctagcggttc gcagtttacc aagcttagcg tcgccttgct cctaaacctt agactgctat
      541 cgcataggca gaactagagg actaaagttc taagttactg ccgcaacata tcacaatgca
      601 tatagccaga ataatttcct aggaattctt gcactaccga accactccga cgctgatcat
      661 ggtggtacag cgtaatccct tgtttctcag ctttcccaga caaaaaagtc caatagtaag
      721 tcagctgact atcactttct aagacccgat aagaggtttc atctgcatga agaagagctt
      781 gttctaacaa cttttctcgt aaaaggttat aaaggggctc caaatagtat tgactcgtct
      841 tgatatgcca attagagatt tccttacgtg tgattggtaa acccatccta gcccaatctt
      901 cttcttggcg ataattgggt accttcagat taaacttctg atggatggtg tgagcgataa
      961 tagaagctga gccaaggcta tgcgc
//
LOCUS       DBMVGT010000189          964 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.189, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000189 DBMVGT010000000
VERSION     DBMVGT010000189.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 964)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.189"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..396)
                     /locus_tag="AC0DU4_002226"
     CDS             complement(<1..396)
                     /locus_tag="AC0DU4_002226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HIN4238118.1"
                     /translation="MYLGDLMEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLT
                     KYVTLLNDKALDSGLELAIHSEDENLRLSIGAATKGRDIRSLFLESAVKYQILVYLLY
                     HQQFLAHQLAQELVISEATLGRHLAGLNQI"
     gene            561..>964
                     /locus_tag="AC0DU4_002227"
     CDS             561..>964
                     /locus_tag="AC0DU4_002227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0051082 - unfolded protein binding
                     [Evidence IEA];
                     GO_process: GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HIN4238119.1"
                     /translation="MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGR
                     TLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATG
                     EVLVGPFVGNGQFLVITDYGTGNPYNSITPLIS"
BASE COUNT          283 a          228 c          177 g          276 t
ORIGIN      
        1 aatctgattt aaaccagcca agtgacgacc aagcgtagcc tcgctaatca ccaattcttg
       61 agccagctga tgggctaaaa actgttggtg gtagagaaga taaaccaaaa tctggtattt
      121 aacagcactc tccaaaaaca agctccgaat atctctcccc ttggtagctg caccgataga
      181 cagacgcaga ttttcatctt ctgagtgaat agccagctct aagccactat ccaaagcctt
      241 gtcattgagc agggtgacat atttggttag ggttgctttt gaaaatcctg tttcttccat
      301 tacagccttg acggtcgtct gagactcttg taatagaaag gaaaggattg aaaattgacc
      361 acactcggct ttctccatca aatctcctaa atacatttgt tacccctttc attttctacc
      421 ttaagcatag cataaatctt acaaatgcta aaataatctg tttctctttt tattttcatg
      481 ctgatttcct ggtccattat cctgaaaatc agtaaacaca cggctccccc tttgggcatt
      541 tttatgctaa aatagtagct atggataaaa ttattaaaac tatatcagaa agcggagcct
      601 ttcgtgcttt tgtccttgat agcacggaaa ccgtccgcac tgctcaagaa aaacatcaaa
      661 cccaagctag ctcaactgta gcgcttggtc gaactcttat cgccagccag attctcgcag
      721 ccaatgaaaa aggaaatacc aaacttacag ttaaggtgtt gggctctagc tctctaggtg
      781 ctattatcac cgtcgctgat accaagggga acgtcaaagg ctatgttcaa aatcctggtg
      841 ttgacatcaa aaagactgcg actggtgaag tcctagtcgg accttttgtt ggaaatggtc
      901 aattcctcgt tatcacagac tacggtactg gaaatcctta caactctata actcccctca
      961 tctc
//
LOCUS       DBMVGT010000190          964 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.190, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000190 DBMVGT010000000
VERSION     DBMVGT010000190.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 964)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.190"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..889)
                     /gene="folP"
                     /locus_tag="AC0DU4_002228"
     CDS             complement(<1..889)
                     /gene="folP"
                     /locus_tag="AC0DU4_002228"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004156 - dihydropteroate synthase
                     activity [Evidence IEA];
                     GO_process: GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HIN4238120.1"
                     /translation="MMKSLEGVTDMSSKANHAKTAICGIINVTPDSFSDGGQFFALEQ
                     ALQQARKLITEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDT
                     WKSQVAEAALAAGANLVNDITGLMGDEKMAHVVAKAGAKVVIMFNPVMARPQHPSSLI
                     FPHFGFNQTFTVEELADFETLPIEDLMVAFFERALARAAEAGIAPENILLDPGIGFGL
                     TKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFEVNPETELGFRNRDTAS
                     AHVTSIAARQGVEVVRVHDV"
BASE COUNT          261 a          245 c          187 g          271 t
ORIGIN      
        1 ctacgtcatg cacgcgcacc acttctacac cctgtctcgc agcgatacta gttacatgag
       61 ccgaagccgt gtcccgattt cggaaaccaa gctctgtctc aggattgact tcaaaaccat
      121 tctcctctag gatattgatg acaaatcgct tgcgcgacac tccgagaaag attggatagc
      181 ccttctgatg tagtttatcc aggtcccgta aaaggaggag attttctttc ttggtcagac
      241 caaagccaat tcctggatcc aacaggatat tttctggtgc aataccagct tctgccgctc
      301 tcgctagtgc tcgttcaaag aaagccacca tcaagtcttc gattggcaat gtttcaaagt
      361 cagctaactc ttctactgta aaagtttgat taaatccaaa atgagggaat atgagcgagc
      421 tagggtgttg aggtcgagcc atgactggat taaacatgat gactactttc gctccagctt
      481 tagcaaccac atgagccatt ttttcatcgc ccatgagacc agtgatatca ttaactagat
      541 tggcaccagc agccaaagca gcctctgcca cctgactttt ccaagtatcg atagaaatga
      601 gtacatcact ttccttgcga atcgctttga tcactggaac aacacgctgg atttcctctt
      661 ctatctcaac atagctactt cccggccgag tcgattctcc gccgatatcg agcatactgg
      721 ctccttctgt tatcaattta cgagcctgct ggagcgcctg ctcaagagca aaaaattgac
      781 caccgtccga aaaggagtct ggggttacat tgataattcc gcaaatagct gtctttgcat
      841 gattggcttt acttgacata tcggtcactc cctcaaggct tttcatcata ttatttctct
      901 attttaccat aaaaagaaaa agatggacac gatttcattc atctttctcc cagtagaaac
      961 aagt
//
LOCUS       DBMVGT010000191          938 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.191, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000191 DBMVGT010000000
VERSION     DBMVGT010000191.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 938)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 938)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..938
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.191"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>938
                     /locus_tag="AC0DU4_002229"
     CDS             <1..>938
                     /locus_tag="AC0DU4_002229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HIN4238121.1"
                     /translation="GSYAGGANRQNNSIFIKPELEQLQKEIAEEEASLGSEEVALKTL
                     QDEMARLTESLEAIKSQGEQARIQEQGLSLAYQQTSQQVEELETLWKLQEEEIDRLSE
                     GDWQADKEKCQERLAAIASDKQNLEAEIEEIKSNKNAIQERYQNLQEELAQARLLKTE
                     LQGQKRYEVADIERLGKELDNLDFEQEEIQRLLQEKVDNLEKVDTELLSQQAEESKTQ
                     KTNLQQGLIRKQFELDDIEGQLDDIASHLDQARQQNEEWIRKQTRAEAKKEKVSERLR
                     HLQSQLTDQYQISYTEALEKAHELENLNLAEQEVKD"
BASE COUNT          331 a          175 c          233 g          199 t
ORIGIN      
        1 tggttcctat gcaggtggag ccaatcgtca gaacaacagc atcttcatca agccagaact
       61 ggagcaatta caaaaagaaa ttgctgaaga agaagcaagc ttgggttcag aagaagtggc
      121 tttgaagacc ttgcaagatg agatggccag attgaccgag tcattagaag ctattaaatc
      181 tcaaggagag caggcacgta ttcaggagca aggcttgtcc ctcgcttatc agcaaactag
      241 tcagcaagtt gaagaactgg aaactctttg gaaactccaa gaagaggaaa tagatcgtct
      301 ttccgaggga gattggcaag cggataagga aaaatgccaa gagcgtcttg ctgcaatcgc
      361 cagtgacaag caaaatctgg aagctgagat tgaagagatt aagtctaata aaaatgccat
      421 ccaagaacgc tatcaaaact tgcaggaaga gctagcgcaa gctcgtttgc ttaagacaga
      481 actgcaaggg caaaaacgtt atgaagttgc tgatattgaa cgcttaggca aggaattgga
      541 caatcttgat tttgaacaag aggaaatcca gcgccttctt caagaaaagg ttgacaatct
      601 tgagaaggtt gatacagaat tgctcagtca acaggcggaa gaatccaaaa ctcagaaaac
      661 gaacctccaa caaggtttga ttcgcaaaca gtttgagttg gatgatatag aaggtcagct
      721 ggatgatatt gctagtcatt tggatcaggc tcgccagcag aatgaggagt ggattcgcaa
      781 gcaaacacgt gctgaagcta agaaagaaaa ggtcagcgag cgcttgcgcc atctacaaag
      841 tcaattaaca gaccagtacc agattagcta tactgaagct ctagaaaaag cgcatgaatt
      901 ggaaaacctc aatctggcag agcaagaagt taaggatt
//
LOCUS       DBMVGT010000192          936 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.192, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000192 DBMVGT010000000
VERSION     DBMVGT010000192.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 936)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 936)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..936
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.192"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..760
                     /gene="comA"
                     /locus_tag="AC0DU4_002230"
     CDS             <1..760
                     /gene="comA"
                     /locus_tag="AC0DU4_002230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter ComA"
                     /protein_id="HIN4238122.1"
                     /translation="SEFEEKKTVEDLSLMKGEMTFKQVHYKYGYGRDVLSDINLTVPQ
                     GSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYINYLPQQP
                     YVFNGTILENLLLGAKEGTTQEDILRAVELVEIREDIERMPLNYQTELTSDGAGISGG
                     QRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAER
                     TEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS"
     gene            773..>936
                     /locus_tag="AC0DU4_002231"
     CDS             773..>936
                     /locus_tag="AC0DU4_002231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComB"
                     /protein_id="HIN4238123.1"
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKE
                     MSLSTRATVEP"
BASE COUNT          244 a          167 c          261 g          264 t
ORIGIN      
        1 ttctgagttt gaggagaaga aaacagttga ggatttgagc ttgatgaagg gagagatgac
       61 tttcaagcag gttcattaca agtatggcta tggtcgagac gtcttgtcgg atatcaattt
      121 aaccgttccc caagggtcta aggtggcttt tgtggggatt tcagggtcag gtaagacgac
      181 tttggccaag atgatggtta atttttacga cccaagtcaa ggggagatta gtctgggtgg
      241 tgtcaatctc aatcagattg ataaaaaagc cctacgccag tacatcaact atctgcctca
      301 acagccctat gtctttaacg gaacgatttt ggagaatctt cttttgggag ccaaggaggg
      361 gacgacacag gaagatatct tacgggcggt cgaattggta gagattcgag aggatatcga
      421 gcgcatgcca ctgaattacc agacagaatt gacttcggat ggggcaggga tttcaggtgg
      481 tcaacgtcag agaatcgctt tggcgcgtgc tctcttgaca gatgcgccgg tcttgatttt
      541 ggatgaggcg actagcagtt tggatatttt gacagagaag cggattgtcg ataatctcat
      601 ggctttggac aagaccttga ttttcattgc tcaccgcttg actattgctg agcggacaga
      661 gaaggtggtt gtcttggatc agggcaagat tgtcgaagaa ggaaagcatg ctgatttgct
      721 tgcacagggt ggcttttacg cccatttggt caatagctag aaagaggaga ggatgaaacc
      781 agaattttta gaaagtgcgg agttttataa tcgtcgttac cataattttt ccagtagtgt
      841 gattgtaccc atggcccttc tgctcgtgtt tttacttggc tttgcaactg ttgcagaaaa
      901 ggagatgagt ttgtccacta gagctactgt cgaacc
//
LOCUS       DBMVGT010000193          930 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.193, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000193 DBMVGT010000000
VERSION     DBMVGT010000193.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 930)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.193"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..447
                     /locus_tag="AC0DU4_002232"
     CDS             <1..447
                     /locus_tag="AC0DU4_002232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0051082 - unfolded protein binding
                     [Evidence IEA];
                     GO_process: GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HIN4238124.1"
                     /translation="AFYLTESQQTPSAVGLNVLLDEEDKVKVAGGFLVQVLPGAKKEE
                     IARFEKRIQEMPAISTLLESDDHIEALLKAIYGDEAYKRLSEEEIRFQCDCSHERFMN
                     ALASLPSSDLQEMKEEDHGAEITCQFCQTTYNFDEKDLEELIRDKS"
     gene            434..>930
                     /locus_tag="AC0DU4_002233"
     CDS             434..>930
                     /locus_tag="AC0DU4_002233"
                     /EC_number="1.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0017150 - tRNA dihydrouridine synthase
                     activity [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase"
                     /protein_id="HIN4238125.1"
                     /translation="MTNLNTPFMIGNVEIPNRTVLAPMAGVTNSAFRTIAKELGAGLV
                     VMEMVSDKGIQYNNEKTLHMLHIDEGENPVSIQLFGSDEDSLARAAEFIQENTKTDIV
                     DINMGCPVNKIVKNEAGAMWLKDPDKIYSIINKVQSVLDIPLTVKMRTGWADPSLAVE
                     NALAA"
BASE COUNT          276 a          236 c          202 g          216 t
ORIGIN      
        1 gccttttacc ttactgaaag ccaacaaacg ccttcagcgg tcggcctcaa tgtccttttg
       61 gacgaggaag acaaggtcaa ggttgcaggt ggtttcctag ttcaagtctt gccaggagcc
      121 aagaaagaag agattgctcg ctttgaaaaa cgcatccaag aaatgccagc tatctctact
      181 cttctcgaaa gcgacgacca tatcgaagcc ctcctcaagg ctatctacgg ggacgaagcc
      241 tacaagcgtc tttctgaaga agaaatccgt ttccaatgtg actgtagcca tgaacgcttt
      301 atgaacgctc ttgccagcct tccaagctca gacttacagg aaatgaaaga agaagaccac
      361 ggggcagaaa tcacttgtca attctgccaa actacttaca actttgatga aaaggacctg
      421 gaggaactca ttcgtgacaa atcttaatac accttttatg attggcaatg ttgagattcc
      481 caatcgtacc gttttagcgc ctatggctgg cgtgaccaac tcagcctttc gtaccatcgc
      541 aaaagagctc ggagctggac tcgttgtaat ggaaatggtc tctgacaaag gaatccaata
      601 caacaacgaa aaaaccctgc acatgcttca tatcgatgag ggcgaaaacc ctgtctctat
      661 ccaacttttt ggtagcgatg aagacagcct agcacgcgca gcagaattca tccaagaaaa
      721 caccaagacc gatatcgtcg atatcaacat gggctgccct gtcaacaaaa tcgtgaagaa
      781 cgaagctgga gctatgtggc tcaaggatcc tgacaagatc tactctatca tcaacaaggt
      841 tcagtctgtc cttgatatcc cccttactgt caaaatgcgt accggatggg cggacccatc
      901 tctggcagta gaaaatgccc tcgctgctga
//
LOCUS       DBMVGT010000194          918 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.194, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000194 DBMVGT010000000
VERSION     DBMVGT010000194.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 918)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.194"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..668
                     /locus_tag="AC0DU4_002234"
     CDS             <1..668
                     /locus_tag="AC0DU4_002234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001108652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HIN4238126.1"
                     /translation="TEDDINHFKQEWDHSTLYFFEKFVTSSEICTFDGLVNKDGKIVF
                     STTFDYAYTPLDLMIYKMDNSYYVLKDMVPKLRKYGEAIVKEFGMKERFFHIEFFREG
                     DDYITIEYNNRPAGGFTIDVYNFAHSLDLYRGYAAIVAGEEFPASEFEPQYCLATSRR
                     ANAHYVYSEENLLAKYSQQFKVKKIMPEAFAELQGDYFYMLTTPSRQEMDQMIADFGQ
                     RQE"
BASE COUNT          281 a          176 c          184 g          277 t
ORIGIN      
        1 agacagaaga cgatatcaat cacttcaagc aagaatggga ccattcaacc ctttatttct
       61 ttgaaaaatt tgtcacttcc agcgaaatct gtacctttga cgggctcgtg aacaaggatg
      121 gaaagattgt tttctcaaca acctttgact acgcctatac accgcttgat ctcatgattt
      181 ataagatgga caattcctac tatgtgctca aggatatggt tcccaaacta cgcaagtatg
      241 gggaagcgat tgttaaggaa tttggtatga aagaacggtt tttccatatt gagttcttcc
      301 gtgaggggga cgattatatt accattgagt acaataaccg ccctgcaggt ggtttcacca
      361 ttgatgttta taactttgct cattccttgg acctctatcg tggatatgca gccattgtcg
      421 caggagaaga gttcccagcg tcagagtttg aacctcagta ttgtttggct acatcacgtc
      481 gtgcaaatgc tcactatgtc tattctgagg agaacttact tgccaaatat agccagcagt
      541 tcaaggttaa aaaaatcatg ccagaggctt ttgcggaact tcaaggagat tacttttata
      601 tgctgacaac tccgagtcga caagaaatgg atcagatgat tgctgatttc ggacaacgtc
      661 aagaataaga actatcggat taaggaaatt cactccctta atccttttgt tttgtctggt
      721 aaaaaataag agcatcctaa caaggtagct atcataaaac ttgttcgata actatttgaa
      781 gcaggattag gtggctagaa attgaatttt aacatttcaa ttgagtcata gtattgtgtt
      841 ttcgtatcct taaatcagct aaaaggatcc atgacgacac ctatacgata tagttttcag
      901 gataccaaac aagtctat
//
LOCUS       DBMVGT010000195          917 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.195, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000195 DBMVGT010000000
VERSION     DBMVGT010000195.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 917)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 917)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..917
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.195"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..299
                     /locus_tag="AC0DU4_002235"
     CDS             <1..299
                     /locus_tag="AC0DU4_002235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015604466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA];
                     GO_process: GO:0019346 - transsulfuration [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="PLP-dependent transferase"
                     /protein_id="HIN4238127.1"
                     /translation="ALAEKYLPKGVGSIFTFHVKGGEAEARKVIDNLEIFSDLANVAD
                     AKSLVVHPATTTHGQLSDKDLEAAGVTPNQIRLSIGLENVEDLIEDLRLALEKI"
     gene            395..>917
                     /locus_tag="AC0DU4_002236"
     CDS             395..>917
                     /locus_tag="AC0DU4_002236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2130 domain-containing protein"
                     /protein_id="HIN4238128.1"
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMRQEL
                     ALAEQKAMNEQQTKLAQKDQEIAQLQSQIENFDTEKELAKKEVEQTSHQALLAKDKEV
                     QALENQLATLRLEHENQLQKTLSDLEKEHDQVKNQLLLQEKENELSLASVKQNYEAQL
                     KAASEQVEFYKNFK"
BASE COUNT          311 a          169 c          214 g          223 t
ORIGIN      
        1 atgccttggc tgagaaatac ttaccaaaag gtgtgggctc aatctttacc ttccatgtca
       61 aaggtgggga ggccgaagcc cgcaaggtca ttgataattt ggaaatcttc tcagaccttg
      121 ctaacgtggc agatgccaag tctcttgttg ttcatccagc aacaaccact cacggtcaat
      181 tgtcagacaa agacctagaa gccgcaggtg ttacaccaaa ccaaatccgc ttgtcgatcg
      241 gacttgaaaa tgtagaggat ttgattgaag atttgcgctt ggccttggaa aaaatttaaa
      301 gtaaaagaag ataaacagtg gttttcgact cgctgttttt gattttcctt catgcatgat
      361 ataatggtta cagaagtcta gaaagaggaa tgtaatgaac gaaatcaaat gtcccaactg
      421 tggggaagtc tttacagtaa atgaaagcca gtatgctgaa cttttgtccc aagtgagaac
      481 ggcagagttt gataaggaac tacacgatag gatgaggcag gaactggcct tggctgagca
      541 aaaggctatg aatgagcaac agactaaact ggctcagaag gatcaagaaa ttgcgcaatt
      601 acagagtcag atcgaaaact ttgatacaga aaaagaattg gccaagaaag aagttgaaca
      661 gacaagccat caggccttat tggctaagga caaggaagta caggctttgg agaaccaatt
      721 ggccactttg cgtttggagc atgaaaatca actgcaaaag accctttctg acctagaaaa
      781 agaacatgat caggtcaaaa atcagctcct cttgcaagaa aaggaaaatg agttgtcttt
      841 ggcttctgtt aagcaaaact atgaagccca gcttaaagca gctagtgaac aagtcgagtt
      901 ttataagaat tttaagg
//
LOCUS       DBMVGT010000196          914 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.196, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000196 DBMVGT010000000
VERSION     DBMVGT010000196.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 914)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 914)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.196"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>914)
                     /locus_tag="AC0DU4_002237"
     rRNA            complement(<1..>914)
                     /locus_tag="AC0DU4_002237"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          196 a          291 c          194 g          233 t
ORIGIN      
        1 gggttgcgct cgttgcggga cttaacccaa catctcacga cacgagctga cgacaaccat
       61 gcaccacctg tcacctctgt cccgaaggaa aactctatct ctagagcggt cagagggatg
      121 tcaagacctg gtaaggttct tcgcgttgct tcgaattaaa ccacatgctc caccgcttgt
      181 gcgggccccc gtcaattcct ttgagtttca accttgcggt cgtactcccc aggcggagtg
      241 cttaatgcgt tagctacggc actaaacccc ggaaagggtc taacacctag cactcatcgt
      301 ttacagcgtg gactaccagg gtatctaatc ctgtttgctc cccacgcttt cgagcctcag
      361 cgtcagttac aagccagaga gccgctttcg ccaccggtgt tcctccatat atctacgcat
      421 ttcaccgcta cacatggaat tccactctcc cctcttgcac tcaagttaaa cagtttccaa
      481 agcctactat ggttaagcca cagcctttaa cttcagactt atctaaccgc ctgcgctcgc
      541 tttacgccca ataaatccgg acaacgctcg ggacctacgt attaccgcgg ctgctggcac
      601 gtagttagcc gtccctttct ggtaagatac cgtcacagtg tgaactttcc actctcacac
      661 tcgttcttct cttacaacag agctttacga tccgaaaacc ttcttcactc acgcggcgtt
      721 gctcggtcag acttccgtcc attgccgaag attccctact gctgcctccc gtaggagtct
      781 gggccgtgtc tcagtcccag tgtggccgat caccctctca ggtcggctat gtatcgtcgc
      841 cttggtgagc cgttacccca ccaactagct aatacaacgc aggtccatct ggtagtgatg
      901 caagtgcacc tttt
//
LOCUS       DBMVGT010000197          901 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.197, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000197 DBMVGT010000000
VERSION     DBMVGT010000197.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 901)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 901)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..901
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.197"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..333
                     /gene="rpsB"
                     /locus_tag="AC0DU4_002238"
     CDS             <1..333
                     /gene="rpsB"
                     /locus_tag="AC0DU4_002238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0015935 - small ribosomal subunit
                     [Evidence IEA];
                     GO_function: GO:0003735 - structural constituent of
                     ribosome [Evidence IEA];
                     GO_process: GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HIN4238129.1"
                     /translation="GIEDMPRIPDVMYVVDPHKEQIAVKEAKKLGIPVVAMVDTNTDP
                     DDIDVIIPANDDAIRAVKLITAKLADAIIEGHQGEDAVAVEAEFAASETQADSIEEIV
                     EVVEGDNA"
     gene            412..>901
                     /gene="tsf"
                     /locus_tag="AC0DU4_002239"
     CDS             412..>901
                     /gene="tsf"
                     /locus_tag="AC0DU4_002239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="translation elongation factor Ts"
                     /protein_id="HIN4238130.1"
                     /translation="MAEITAKLVKELREKSGAGVMDAKKALVETDGDIEKAIELLREK
                     GMAKAAKKADRVAAEGLTGVYVNGNVAAVIEVNAETDFVAKNAQFVELVNTTAKVIAE
                     GKPANNEEALALIMPSGETLEAAYVSATATIGEKISFRRFALIEKTDAQHFGAYQHNG
                     GRI"
BASE COUNT          301 a          161 c          210 g          229 t
ORIGIN      
        1 ggtatcgaag atatgcctcg tatcccagat gtgatgtacg tagttgaccc acataaagag
       61 caaatcgctg ttaaagaagc taaaaaattg ggaatcccag ttgtagcgat ggttgacacc
      121 aatactgatc cagatgatat cgatgtaatc atcccagcta acgatgacgc tatccgtgct
      181 gttaaattga tcacagctaa attggctgac gctattatcg aaggacatca aggtgaggat
      241 gcagtagcag ttgaagcaga atttgcagct tcagaaactc aagcagattc aattgaagaa
      301 atcgttgaag ttgtagaagg tgacaacgct taatttatac aaatagtaat tacctaggag
      361 ggcggggctt agcccggctc tcctattttc aaaaaatata ggagaattaa aatggcagaa
      421 attacagcta aacttgtaaa agagttgcgt gaaaaatctg gtgccggtgt tatggacgct
      481 aaaaaagcgc ttgtagaaac agacggtgac atcgaaaaag cgattgaatt gcttcgtgaa
      541 aaaggtatgg ctaaggcagc taagaaagct gaccgtgttg ctgcagaagg tttgactggt
      601 gtttatgtta acggtaatgt tgcagcagtt attgaagtaa acgctgaaac tgacttcgtt
      661 gcaaaaaacg ctcaattcgt tgaattggta aatactacag ctaaagtcat tgctgaagga
      721 aaacctgcta acaatgaaga agctcttgct ttgataatgc cttcaggtga aactcttgaa
      781 gctgcatacg tatctgcaac agcaactatc ggagagaaaa tctcattccg tcgctttgca
      841 ttgattgaaa aaacagacgc acaacacttt ggagcatacc aacataacgg tggacgtatc
      901 g
//
LOCUS       DBMVGT010000198          891 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.198, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000198 DBMVGT010000000
VERSION     DBMVGT010000198.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 891)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 891)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.198"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..780)
                     /gene="dnaI"
                     /locus_tag="AC0DU4_002240"
     CDS             complement(<1..780)
                     /gene="dnaI"
                     /locus_tag="AC0DU4_002240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein DnaI"
                     /protein_id="HIN4238131.1"
                     /translation="MESVGDVLKRQPSRFYYQDLVQKIMKDPDVAAFIQQESLTPEEL
                     NRSISKFNQYITERDKFLRGDTDYIAKGYKPILVKNHGYADVSYEETPELIAAEKEAA
                     IKNRLKLINLPASLKKASLAQVDLDDLGRLPVFEKLLAFVEQYPAIRKGLYLYGDFGV
                     GKSFMVAALAHDLSEKRGVSSTLLHYPSFVIDVKNAISDGNVKTLVDEIKFSEVLILD
                     DIGAEQSTAWVRDEILQVILQYRMQENLPTFFTSNFNFEDLE"
BASE COUNT          252 a          202 c          171 g          266 t
ORIGIN      
        1 ctccaaatct tcaaagttga agttagaggt gaaaaaggtc ggtaaatttt cctgcatccg
       61 atattggaga atgacctgca ggatttcatc acgcacccaa gcggtggatt gctcggcacc
      121 aatatcatct aaaatcagga cttcagaaaa cttaatctca tccaccaagg tcttaacatt
      181 gccatcactg atagcatttt tgacatcaat gacaaagcta ggatagtgga ggagagttga
      241 tgaaacacca cgtttttctg ataaatcatg agctaaggcc gccaccatga aacttttacc
      301 cacaccaaag tctccatata agtaaagacc ttttcgaata gctggatatt gctccacgaa
      361 ggctagtagc ttttcaaaaa ctggtaagcg ccccaaatca tccaagtcaa cttgagccaa
      421 actagctttc ttgagactgg ctggtagatt gattaacttg agacggttct taatagccgc
      481 ttctttttca gccgcgatta gctcaggagt ttcttcatat gaaacatctg catagccatg
      541 attcttaacc aaaatcggct tgtagccttt ggcaatataa tccgtatccc cacggagaaa
      601 cttgtcacgc tcggtgatgt actgattaaa cttggagata ctgcgattta attcctctgg
      661 agtcaaggat tcttgctgga taaaagccgc aacatcaggg tccttcatga ttttctggac
      721 caaatcttga taataaaaac ggctgggttg acgtttgagt acgtctccga cactttccat
      781 ctaatctcct cctttttcta atcgagctaa tagttcttgc ttcttacgtt ctagttccag
      841 acgagtttcc tcgctggttt cattcttata ttcaggatta ctccatttag g
//
LOCUS       DBMVGT010000199          886 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.199, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000199 DBMVGT010000000
VERSION     DBMVGT010000199.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 886)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 886)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.199"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..654)
                     /locus_tag="AC0DU4_002241"
                     /pseudo
     CDS             complement(1..654)
                     /locus_tag="AC0DU4_002241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572848.1"
                     /note="internal stop; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
BASE COUNT          256 a          190 c          172 g          268 t
ORIGIN      
        1 ttcgaagatt gggatgtagg agaaaagttt tcgctccatg agttctgata agatatttaa
       61 gagtccttgc ttcatataca atcgattgtg tactaactct ttaaattctt tggatttttc
      121 gagtaaggag gttgataaaa aaatcagatc ttgattgctc aagaagggca tggtattgca
      181 aaagagatag agttcaaacc aggtccaaga ctcgatagca tagagatagg tggtcaaaaa
      241 ctcgctatcc tcctctgcta gtgggtagct tttatttagt gaatggatgg catctttaat
      301 cacgatggca ttcaaacgac gataggtctg cgccatctgt tcttgatcga cttcctccaa
      361 tagctgctct aaagcagcta tatcctgatg ggcaaagcga ttcacaacct ttcgaccgat
      421 tcgcatatgt ggagattctt gatagttgtt gagcttgtgc ccaaactcat ccaaggtcac
      481 atttatacct tggatagcta gaatcaactt atccgcagac agcatagact accctagttc
      541 aaacttggac aactgagaag ctgttagacc ctcacaagcc acatctgtct gcttaagctt
      601 tctcgccaaa cgtaattcct tgtaaaattc ccccagttcc attttttcaa tcatcctacc
      661 acctcctagc ttttgcatat tatatcatta tttgtgttca tttgtcaaaa cattctgaca
      721 ctttggtgat tgaaaaagcc agccttaagc tgactctaaa aggaccgagc cttgtacaat
      781 acagaactca atcctcgttc taaatagaat gtctaacttt tttgggcagt acacgagctt
      841 ggggaacatc cactggaacg atgaggtgtg agctcaaaat atcctc
//
LOCUS       DBMVGT010000200          862 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.200, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000200 DBMVGT010000000
VERSION     DBMVGT010000200.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 862)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.200"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>862
                     /gene="trmFO"
                     /locus_tag="AC0DU4_002242"
     CDS             <1..>862
                     /gene="trmFO"
                     /locus_tag="AC0DU4_002242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate--tRNA-(uracil(54)-
                     C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO"
                     /protein_id="HIN4238132.1"
                     /translation="GGALAVDRDGFSQMVTEKVVNHPLIEVVRDEITELPTDVITVVA
                     TGPLTSDALAEKIHALNNGDGFYFYDAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNA
                     PMTKQEFMDFHEALVNAEEAPLNSFEKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGL
                     EYPDDYTGPRDGEFKTPYAVVQLRQDNAAGSLYNIVGFQTHLKWGEQKRVFQMIPGLE
                     NAEFVRYGVMHRNSYMDSPNLLEQTYRSKKQPNLFFAGQMTGVEGYVESAASGLVAGI
                     NAARLFKEESE"
BASE COUNT          235 a          180 c          214 g          233 t
ORIGIN      
        1 ggtggagccc ttgcggtgga tcgtgatggt ttctctcaaa tggtgaccga aaaagtggtc
       61 aaccacccct tgattgaagt ggtgcgtgat gaaattacag aattgccaac agatgttatt
      121 acagttgtgg cgactggtcc cttgactagc gatgccctgg ctgaaaagat tcatgccctt
      181 aataatggcg atggcttcta tttctacgat gcagcagcgc ctattatcga tgtcaacact
      241 atcgatatga gtaaggtcta tctcaaatct cgttatgata agggagaagc agcctatctc
      301 aatgctccaa tgaccaagca agagtttatg gatttccatg aagccttggt caatgcggaa
      361 gaagcaccgc tcaattcttt tgaaaaagaa aagtactttg aaggatgtat gccaatcgaa
      421 gttatggcca aacgtggcat taaaactatg ctttatggcc ctatgaagcc agtcggtctt
      481 gagtatccgg acgactacac aggacctcgt gatggagaat ttaaaacacc ttatgcggtt
      541 gtgcaacttc gtcaggataa tgcagctggt agcctataca atattgttgg tttccagacc
      601 cacctcaaat ggggagaaca aaagcgtgtc ttccaaatga ttccgggtct tgaaaatgcg
      661 gagtttgtcc gttatggtgt catgcatcgc aattcttaca tggattcacc aaatcttctt
      721 gagcagactt accgttccaa gaaacaacca aatctcttct ttgctggtca gatgacgggg
      781 gtggaaggct atgttgagtc ggcggcttcg ggcttagttg cgggaattaa cgcagctcgt
      841 ctcttcaagg aagaaagcga gg
//
LOCUS       DBMVGT010000201          843 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.201, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000201 DBMVGT010000000
VERSION     DBMVGT010000201.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 843)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 843)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.201"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..599)
                     /locus_tag="AC0DU4_002243"
     CDS             complement(<1..599)
                     /locus_tag="AC0DU4_002243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000772208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004637 - phosphoribosylamine-glycine
                     ligase activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HIN4238133.1"
                     /translation="MKLLVVGSGGREHAIAKKLLESKDVEKVFVAPGNDGMTLDGLEL
                     VNISISEHSKLIDFAKTNDVAWTFIGPDDALAAGIVDDFNQAGLKTFGPTRAAAELEW
                     SKDFAKEIMVKYGVSTAAYGTFSDFEEAKAYIEKHGAPIVVKADGLALGKGVVVAETV
                     EQAVEAAHEMLLDNKFGDSGARVVIEEFLEGEEFSLFAFV"
     gene            complement(721..>843)
                     /locus_tag="AC0DU4_002244"
     CDS             complement(721..>843)
                     /locus_tag="AC0DU4_002244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP cyclohydrolase"
                     /protein_id="HIN4238134.1"
                     /translation="KAGIKAIIQPGGSVRDQESIEAADKYGLTMVFTGVRHFRH"
BASE COUNT          242 a          227 c          144 g          230 t
ORIGIN      
        1 acaaaggcaa agagtgaaaa ttcctctcct tcaaggaatt cctcaataac cacgcgcgca
       61 cctgagtcac caaatttatt gtccaaaagc atctcatgag cggcttcgac cgcttgctca
      121 accgtctcag caacgacgac acccttccca agcgccaagc catccgcctt gactacgata
      181 ggcgcaccat gcttttcgat ataagccttt gcttcctcga aatctgaaaa tgtgccatag
      241 gctgctgtcg aaacaccata tttgaccatg atttccttgg caaaatcctt ggaccactcc
      301 agctccgctg cagccctagt cggaccaaag gtcttaagcc cagcttggtt aaaatcatcc
      361 acgataccag cagcaagggc atcatctgga ccgataaagg tccaagcaac atcattggtc
      421 tttgcgaagt caatcaattt agaatgttcg gaaatagaga tatttaccaa ttccaaacca
      481 tccagagtca tcccatcatt cccaggagct acaaagactt tttccacatc ttttgattca
      541 agtaactttt tagcaatcgc atgctcacga ccacccgaac cgacaacaag cagtttcatt
      601 cctcaacctc ttttgcgaat tatttaccaa tattatatca aaaaagttcg ttttaatctt
      661 gtttcagtta gcattttaag ccaaaaaagg aaagaaactg ttttcttccc ttttatcttc
      721 ttaatgtcta aaatgtctca cacctgtaaa gaccatagtc aagccgtatt tatccgctgc
      781 ttcgatggat tcttggtcac ggacagagcc accgggctgg atgatggcct taattcctgc
      841 ttt
//
LOCUS       DBMVGT010000202          843 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.202, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000202 DBMVGT010000000
VERSION     DBMVGT010000202.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 843)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 843)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.202"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..599)
                     /locus_tag="AC0DU4_002245"
     CDS             complement(<1..599)
                     /locus_tag="AC0DU4_002245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000772208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004637 - phosphoribosylamine-glycine
                     ligase activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA];
                     GO_process: GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HIN4238135.1"
                     /translation="MKLLVVGSGGREHAIAKKLLESKDVEKVFVAPGNDGMTLDGLEL
                     VNISISEHSKLIDFAKTNDVAWTFIGPDDALAAGIVDDFNQAGLKAFGPTRTAAELEW
                     SKDFAKEIMVKYGVSTAAYGTFSDFEEAKAYIEKHGAPIVVKADGLALGKGVVVAETV
                     EQAVEAAHEMLLDNKFGDSGARVVIEEFLEGEEFSLFAFV"
     gene            complement(721..>843)
                     /locus_tag="AC0DU4_002246"
     CDS             complement(721..>843)
                     /locus_tag="AC0DU4_002246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP cyclohydrolase"
                     /protein_id="HIN4238136.1"
                     /translation="KAGIKAIIQPGGSVRDQESIEAANKYGLTMVFTGVRHFRH"
BASE COUNT          241 a          226 c          146 g          230 t
ORIGIN      
        1 acaaaggcaa agagtgaaaa ttcctctcct tcaaggaatt cctcaataac cacgcgcgca
       61 cctgagtcac caaatttatt gtccaaaagc atctcatgag cggcttcgac cgcttgctca
      121 accgtctcag caacgacgac acccttccca agcgccaagc catccgcctt gactacgata
      181 ggcgcaccat gcttttcgat ataggccttt gcttcctcga aatctgaaaa tgtgccatag
      241 gctgctgtcg aaacaccata tttgaccatg atttccttgg caaaatcctt ggaccactcc
      301 agctccgctg cagtcctagt cggaccaaag gccttaagcc cagcttggtt aaaatcatcc
      361 acgataccag cagcaagggc atcatctgga ccgataaagg tccaagcaac atcattggtc
      421 tttgcgaagt caatcaattt agaatgttcg gaaatagaga tatttaccaa ttccaaacca
      481 tccagagtca tcccatcatt cccaggagct acaaagactt tttccacgtc ttttgattca
      541 agtaactttt tagcaatcgc atgctcacga ccaccagaac cgacaacaag cagtttcatt
      601 cctcaacctc ttttgcgaat tatttaccaa cattatatca aaaaagttcg ttttaatctt
      661 gtttcagtta gcattttaag ccaaaaaagg aaagaaactg ttttcttccc ttttatcttc
      721 ttaatgtcta aaatgtctca cacctgtaaa gaccatagtc aagccgtatt tattcgctgc
      781 ttcgatggat tcttggtcac ggacagagcc accgggctgg atgatggcct taattcctgc
      841 ttt
//
LOCUS       DBMVGT010000203          812 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.203, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000203 DBMVGT010000000
VERSION     DBMVGT010000203.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 812)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.203"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..164
                     /locus_tag="AC0DU4_002247"
     CDS             <1..164
                     /locus_tag="AC0DU4_002247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="SAM-dependent methyltransferase"
                     /protein_id="HIN4238137.1"
                     /translation="EANHHGFDLAELENKLIEHGFSSVHSQILYSAEDLFQGNHSEFF
                     LIVAQKSLA"
     gene            225..>812
                     /locus_tag="AC0DU4_002248"
     CDS             225..>812
                     /locus_tag="AC0DU4_002248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000345081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HIN4238138.1"
                     /translation="MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGET
                     ELEQVKDNNQTLKRLALRKEEWLKTYQFLLMKAGQTEPLQANHQFTPDAIALLLVFIV
                     EELFKEEEITILEMGSGMGILGATFLTSLTKKVDYLGMEVDDLLIDLAASMADVIGLQ
                     AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVAS"
BASE COUNT          240 a          144 c          195 g          233 t
ORIGIN      
        1 cagaagctaa tcatcatgga tttgatttag ctgaactgga aaacaagcta attgagcatg
       61 gtttttcatc tgtgcatagt cagattctct atagcgctga agacctgttt caaggaaatc
      121 actcagaatt ctttttaata gtagcccaaa aatcactcgc ctagtcaggg agtgattttt
      181 ctataagaat ggaaaaaaga agggaaattt gataagatag gaatatggat tttgaaaaaa
      241 ttgaacaagc ttatacctat ttactagaga atgtccaagt catccaaagt gatttggcga
      301 ccaactttta tgacgccttg gtggagcaaa acagcatcta tctggatggt gagactgagc
      361 tagaacaggt caaagacaac aatcagaccc ttaagcgttt agcactacgc aaagaagaat
      421 ggctcaagac ctaccagttt ctcttgatga aggctgggca aacagaaccc ttgcaggcca
      481 atcaccagtt tacaccggat gctattgctt tacttttggt gtttattgtg gaagagctgt
      541 ttaaagagga ggaaattact atcctcgaaa tgggttctgg gatgggaatt ttgggcgcta
      601 ctttcttgac ctcgcttact aaaaaggtgg attatttggg aatggaagtg gatgatttgc
      661 tgattgatct ggcagctagc atggcagatg taattggttt gcaggctggc tttgtccaag
      721 gagatgccgt tcgtccacaa atgctcaaag aaagcgatgt ggtcatcagt gacttgcctg
      781 ttggctatta tcctgatgat gccgttgcgt cg
//
LOCUS       DBMVGT010000204          810 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.204, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000204 DBMVGT010000000
VERSION     DBMVGT010000204.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 810)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 810)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.204"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            278..>810
                     /locus_tag="AC0DU4_002249"
     CDS             278..>810
                     /locus_tag="AC0DU4_002249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000090325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003924 - GTPase activity [Evidence IEA];
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-binding protein"
                     /protein_id="HIN4238139.1"
                     /translation="MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETH
                     EGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGA
                     VTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAH
                     PIQLPIGSEDDFRGIID"
BASE COUNT          261 a          187 c          159 g          203 t
ORIGIN      
        1 gtgaaaatag gaaactgacg cagtattcga cgaatacaag gagttttatc tttttcacgc
       61 agcatcccgt tccagctcac atcggctaac taactttagc ccgggttcaa attagctaaa
      121 tcgattagta ttagctataa ctcagcttac catctcgtaa gttgaaacca acaatagcat
      181 gaaaacattg agaacgggta ggtcctgcct atccgttttt attaaaatcg tgttataata
      241 gaatagaaat caaaaataaa taggagaaac aaacctcatg gcacgcgaat tttcacttga
      301 aaaaactcgt aatatcggta tcatggctca cgtcgatgcc ggtaaaacaa caactactga
      361 gcgtattctt tactacactg gtaaaatcca caaaatcggt gaaactcacg aaggtgcgtc
      421 acaaatggac tggatggagc aagagcaaga acgtggtatc acgatcacat ctgctgcgac
      481 aacagctcaa tggaacaacc accgcgtaaa catcatcgac acaccaggac acgtggactt
      541 cacaatcgaa gtacaacgtt ctcttcgtgt attggatggt gcggttaccg ttcttgactc
      601 acaatcaggt gttgagcctc aaactgaaac agtttggcgt caagcaactg agtacggagt
      661 tccacgtatc gtatttgcca acaaaatgga caaaatcggt gctgacttcc tttactctgt
      721 aagcacactt cacgatcgcc ttcaagcaaa tgcacaccca atccaattgc caatcggttc
      781 tgaagatgac ttccgtggta tcattgactt
//
LOCUS       DBMVGT010000205          803 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.205, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000205 DBMVGT010000000
VERSION     DBMVGT010000205.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 803)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 803)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.205"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            135..803
                     /locus_tag="AC0DU4_002250"
                     /pseudo
     CDS             135..803
                     /locus_tag="AC0DU4_002250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000472064.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip domain-containing protein"
BASE COUNT          288 a          113 c          131 g          271 t
ORIGIN      
        1 tttttaagcg tttgttactt tcttgcatat ttcctccttg taaacaaatt agactatatg
       61 tctaaaaata gattttttat cttgtaattt agatttttta atgtataatc tattatatca
      121 aaattttaga caatatgttt aaaaaaggag aaactaagtt taaagaatgg aaagcaattt
      181 aaaaaaaaca acctttatta ttgtcatgat cgggatttct cttattccag atctgtacaa
      241 tatcatattt ttgtcatcaa tgtgggatcc atatgggcaa ttgtctgact tacctgtggc
      301 agttgtaaat aatgataaag aggcttccta taatggtaat actatggcaa taggaaaaga
      361 catggtgtcc aatttaaaag aaaataaaac cttggatttt cattttgtag atgaagagga
      421 aggaaagaag ggattggaag atggcgatta ctatatggta gtgactttac caagtgattt
      481 atctgaaaaa acaactacat tatccaatat tcaatcgaca gcagcttatc aatcattgac
      541 aagtgagcaa caaactgaga taagtgattc tgtatctcaa aattcaactg atagtattca
      601 atcggctcag tcaattgtag ctttagtaca agatttacag ggaagtttag aaaacttaca
      661 aaatcaatct tctaatcttt cgactttaaa aaatcaatct aatcaagtat cacctattac
      721 ttctacttct ttgataggat tgtcaagtgg attaacagag atacaaggag atgttactag
      781 caaattagtt cctgccagtc agt
//
LOCUS       DBMVGT010000206          766 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.206, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000206 DBMVGT010000000
VERSION     DBMVGT010000206.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 766)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 766)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.206"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>766
                     /locus_tag="AC0DU4_002251"
     CDS             <1..>766
                     /locus_tag="AC0DU4_002251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA];
                     GO_process: GO:0006418 - tRNA aminoacylation for protein
                     translation [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="class I tRNA ligase family protein"
                     /protein_id="HIN4238140.1"
                     /translation="LHNLNETIGKATANFDKFEFGVAGHILYNFIWEEFANWYVELTK
                     EVLYSDNEDDKVITRSVLLYTLDKILRLLHPIMPFVTEEIFGQYAEGSIVTAAYPTVN
                     PAFEDLAAHTGVESLKDLIRAVRNARAEVNVAPSKPITILVKTSDSDLEAFFNSNVNY
                     IKRFTNPEHLEIASTIPAPELAMSSVITGAEIFLPLVDLLNVEEELARLEKELAKWQK
                     ELDMVGKKLSNERFVANAKPEVVQKEKDKQADYQAKY"
BASE COUNT          239 a          189 c          155 g          183 t
ORIGIN      
        1 tctccacaac ctcaatgaaa cgattggaaa agcaactgct aactttgata agtttgagtt
       61 tggtgttgct ggccacatcc tctacaactt catttgggaa gaatttgcca actggtatgt
      121 tgagttgacc aaggaagttc tttacagcga caatgaagac gataaggtca ttactcgatc
      181 tgttctcctc tatacgctgg ataaaatcct ccgtcttctt cacccaatca tgccattcgt
      241 gacagaagaa atctttggtc agtacgctga aggctctatc gtgacagcag catacccaac
      301 tgtcaaccca gcctttgagg accttgctgc ccacactggt gtggaaagtc tcaaagactt
      361 gatccgtgcc gttcgtaatg cgcgtgcgga agtaaatgta gcaccaagca aacctatcac
      421 catccttgtt aagacaagcg atagcgactt ggaagccttc tttaacagca atgtcaacta
      481 tatcaaacgc tttacaaatc cagaacactt ggaaatcgca tcaaccatcc ctgcacctga
      541 actggctatg tcaagcgtta ttacaggagc cgaaatcttc ttgccactgg tagacctctt
      601 gaatgtcgaa gaagaattgg cacgtctgga aaaagaactt gccaaatggc agaaagaact
      661 cgacatggtt ggcaaaaaac tcagcaacga acgcttcgtc gccaacgcta aaccagaagt
      721 tgtccaaaaa gaaaaagaca aacaagccga ctaccaagcc aagtat
//
LOCUS       DBMVGT010000207          761 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.207, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000207 DBMVGT010000000
VERSION     DBMVGT010000207.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 761)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 761)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..761
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.207"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>761
                     /locus_tag="AC0DU4_002252"
     CDS             <1..>761
                     /locus_tag="AC0DU4_002252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HIN4238141.1"
                     /translation="DQVLERQPNLKKEGLVGGGVYLDFRNNDARLVIENIKRANQDGA
                     LIANHVKAEGFLFDESGKITGVVARDLLTDQVFEIKARLVINTTGPWSDKVRNLSNKG
                     TQFSQMRPTKGVHLVVDSSKIKVSQPVYFDTGLGDGRMVFVLPRENKTYFGTTDTDYT
                     GDLEHPKVTQEDVDYLLGIVNNRFPESNITIDDIESSWAGLRPLIAGNSASDYNGGNN
                     GTISDESFDNLIATVESYLSKEKTREDVESAVSKL"
BASE COUNT          228 a          158 c          179 g          196 t
ORIGIN      
        1 aggatcaagt cttggaacgc cagccaaact tgaagaagga aggcttggta ggaggtggag
       61 tgtatcttga cttccgtaac aacgatgcgc gtctcgtgat tgaaaacatc aaacgtgcca
      121 accaagacgg tgccctcatt gccaaccacg tgaaggcaga aggcttcctc tttgacgaaa
      181 gtggcaagat tacaggtgtt gtagctcgtg atctcttgac agaccaagta tttgaaatca
      241 aggcccgtct ggttattaat acaacaggtc cttggagtga taaagtacgt aatttgtcta
      301 ataagggaac gcaattctca caaatgcgcc caactaaggg agttcacttg gtagtggatt
      361 caagcaaaat caaggtttca cagccagttt acttcgacac aggtttgggt gacggtcgta
      421 tggtctttgt tctcccacgt gaaaacaaga cttactttgg tacaactgat acagactaca
      481 caggtgattt ggagcatcca aaagtaactc aagaagatgt agattatcta cttggcattg
      541 tcaacaaccg ctttccagaa tccaacatca ccattgatga tatcgaaagc agctgggcag
      601 gtcttcgtcc attgattgca gggaacagtg cctctgacta taatggtgga aataacggta
      661 ccatcagtga tgaaagcttt gacaacttga ttgcgactgt tgaatcttat ctctccaaag
      721 aaaaaacacg tgaagatgtt gagtctgctg tcagcaagct t
//
LOCUS       DBMVGT010000208          761 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.208, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000208 DBMVGT010000000
VERSION     DBMVGT010000208.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 761)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 761)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..761
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.208"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..278
                     /locus_tag="AC0DU4_002253"
     CDS             <1..278
                     /locus_tag="AC0DU4_002253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA];
                     GO_process: GO:0001522 - pseudouridine synthesis [Evidence
                     IEA];
                     GO_process: GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="pseudouridine synthase"
                     /protein_id="HIN4238142.1"
                     /translation="GLEIDGKKTKPAVYEILKVDPVKNRSVVQLTIHEGRNHQVKKMF
                     EAVGLQVDKLSRTRFGHLDLTGLRPGESRRLNKKEISQLHTMAVTKK"
     gene            278..520
                     /gene="yidD"
                     /locus_tag="AC0DU4_002254"
     CDS             278..520
                     /gene="yidD"
                     /locus_tag="AC0DU4_002254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HIN4238143.1"
                     /translation="MKRILIAPVRFYQRFISPVFPPSCRFELTCSNYMIQAIEKHGFK
                     GVLMGLARILRCHPWSKTGKDPVPDRFSLKRNQEGE"
BASE COUNT          217 a          152 c          162 g          230 t
ORIGIN      
        1 gtggtcttga gattgatggt aagaaaacca agccagctgt ttatgaaatt ctcaaagtgg
       61 acccagtcaa aaatcgctct gtggtgcagt tgaccatcca tgaagggcgt aaccatcagg
      121 ttaaaaagat gtttgaagct gttggtctcc aagtagataa gttgtctcgg actcgtttcg
      181 gacacctaga cttgacagga ctccgtccag gagaatcccg tcgtcttaat aaaaaagaaa
      241 tcagccaact acacaccatg gctgtaacta agaaataatg aaacgaattt taatagcgcc
      301 tgtgcgcttt taccaacgtt ttatctcacc agtctttcca ccctcttgtc gctttgagct
      361 gacttgttcc aactacatga ttcaggctat tgaaaaacat ggttttaagg gggtattgat
      421 gggcttggct cggattttac gttgtcatcc ctggtcgaaa acaggtaagg accccgttcc
      481 agaccgcttt tcccttaaac gaaatcaaga aggggaatga ggtggggtaa atagatttca
      541 aaatgataaa aacgcatcct atcaggtttg agtgaacttg ataggatgcg ttttagaatg
      601 tcaaaatttt atactcttcg aaaatctctt caaaccgcgt cagctttcat ctgcaacctc
      661 aaaacagtgt tttgagcaac ctgcggctag ttttctagtt tgctctttga ttttcattga
      721 gtattaaatt gagtttgaag tggcttattt caaagctttt t
//
LOCUS       DBMVGT010000209          750 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.209, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000209 DBMVGT010000000
VERSION     DBMVGT010000209.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 750)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 750)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.209"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..178
                     /locus_tag="AC0DU4_002255"
     CDS             <1..178
                     /locus_tag="AC0DU4_002255"
                     /EC_number="2.7.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189889.1"
                     /note="catalyzes the formation of alpha-D-galactose
                     1-phosphate from D-galactose in galactose metabolism;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="galactokinase"
                     /protein_id="HIN4238144.1"
                     /translation="VLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYKEVVGYAPS
                     FYIAEVAGGTRVLD"
     gene            197..>750
                     /locus_tag="AC0DU4_002256"
     CDS             197..>750
                     /locus_tag="AC0DU4_002256"
                     /EC_number="2.7.7.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861845.1"
                     /note="catalyzes the formation of alpha-D-glucose
                     1-phosphate and UDP-galactose from UDP-glucose and
                     alpha-D-galactose 1-phosphate in galactose metabolism;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose--hexose-1-phosphate
                     uridylyltransferase"
                     /protein_id="HIN4238145.1"
                     /translation="MTLVDKFVTHVISESSFEEMDRIYLTNRVLARVGEGVLEVETNL
                     DKLIDLKDQLVEEAVRLETIEDSQTAREILGTELMDLVTPCPSQVNRDFWEAYVHSPE
                     QAIEDFYQLSQKNDYIKLKAIAKNIAYRVPSDYGELEITINLSKPEKDPKEIAAAKLV
                     QASNYPQCQLCLENEGYHGRVNHPA"
BASE COUNT          208 a          146 c          189 g          207 t
ORIGIN      
        1 agttctcggt gctcgtatga caggggctgg ttttggtggc tgtgccattg ccttggttca
       61 aaaagatact gttgaggcct ttaaggaagc tgtaggcaaa cactacaagg aagtagttgg
      121 atacgctcca agcttctata tcgctgaagt tgcaggtggc actcgcgtcc ttgactagtc
      181 aaaaggaggc tctatagtga ccttagtaga taaatttgta acacatgtca tttctgaaag
      241 ttcatttgag gaaatggatc gaatctacct gaccaatcgt gttttggcac gagtgggaga
      301 aggtgttttg gaagttgaga ccaatctgga taaattgatt gacctcaagg accagctagt
      361 tgaggaagcc gttcgattag agacgattga ggatagtcag actgcgcgtg aaatccttgg
      421 tactgaattg atggacttgg tgactccttg tccgagtcag gtcaatcgtg acttctggga
      481 agcctatgtc cactctcctg agcaagcgat agaggatttt tatcaactca gtcagaaaaa
      541 tgactacatc aaactcaagg ccattgctaa aaatatcgct tatcgtgttc catctgatta
      601 tggagaactt gaaattacca tcaatctctc taagcctgaa aaggatccga aagagattgc
      661 ggcagccaag ttggtgcaag ctagtaatta tcctcagtgt caactttgtt tagagaatga
      721 gggttaccat ggtcgggtca accacccagc
//
LOCUS       DBMVGT010000210          748 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.210, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000210 DBMVGT010000000
VERSION     DBMVGT010000210.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 748)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 748)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.210"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..384
                     /locus_tag="AC0DU4_002257"
     rRNA            <1..384
                     /locus_tag="AC0DU4_002257"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
     gene            436..508
                     /locus_tag="AC0DU4_002258"
     tRNA            436..508
                     /locus_tag="AC0DU4_002258"
                     /product="tRNA-Ala"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:469..471,aa:Ala,seq:tgc)
     gene            633..>748
                     /locus_tag="AC0DU4_002259"
     rRNA            633..>748
                     /locus_tag="AC0DU4_002259"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT          206 a          163 c          214 g          165 t
ORIGIN      
        1 tgccggtaat aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc
       61 tgggctacac acgtgctaca atggctggta caacgagtcg caagccggtg acggcaagct
      121 aatctcttaa agccagtctc agttcggatt gtaggctgca actcgcctac atgaagtcgg
      181 aatcgctagt aatcgcggat cagcacgccg cggtgaatac gttcccgggc cttgtacaca
      241 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cgtaaggagc
      301 cagccgccta aggtgggata gatgattggg gtgaagtcgt aacaaggtag ccgtatcgga
      361 aggtgcggct ggatcacctc ctttctaagg ataaggaact gcgcattggt cttgtttagt
      421 cttgagaggt cttgtggggc cttagctcag ctgggagagc gcctgctttg cacgcaggag
      481 gtcagcggtt cgatcccgct aggctccatt ggtgagagat caccaagtaa tgcacattga
      541 aaattgaata tctatatcaa atagtaacaa gaaaataaac cgaaaacgct gtagtattaa
      601 taagagttta tgactgaaag gtcagaaaat aaggttaagt taataagggc gcacggtgga
      661 tgccttggca ctaggagccg acgaaggacg tgacaaacga cgatatgcct tgggtagctg
      721 taagtaagcg atgatccagg gatttccg
//
LOCUS       DBMVGT010000211          746 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.211, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000211 DBMVGT010000000
VERSION     DBMVGT010000211.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 746)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 746)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.211"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>746
                     /locus_tag="AC0DU4_002260"
     CDS             <1..>746
                     /locus_tag="AC0DU4_002260"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HIN4238146.1"
                     /translation="WYKMARLGADFYVDLLADLEKSGQKIDFYQRSGVFLLKKDESKL
                     EELYQLALQRREESPLIGQLAILDQASANELFPGLQGFDRLLYASGGARVDGHLLVTR
                     LLEASQVKLVKEKVTLTPLASGYQIGEEEFEQVILATGAWLGDMLEPLGYEVDVRPQK
                     GQLRDYQLVQDMEAYPVVMPEGEWDLIPFAGGKLSLGATHENDMGFDLTVDETLLQQM
                     EEATLTHYLILAEATSKSERVGIRAYTSDFS"
BASE COUNT          194 a          148 c          200 g          204 t
ORIGIN      
        1 tggtacaaga tggcgcgctt gggggctgat ttttatgtgg atttattagc tgatttagag
       61 aaatcaggac aaaaaatcga cttttaccag cgttcgggag tctttctctt gaaaaaggat
      121 gaatctaagt tggaagaact ttatcaactg gccctccagc gcagagaaga atctcccttg
      181 atagggcaat tagccattct ggaccaagcc tcagctaatg aattattccc tggtttgcag
      241 ggatttgacc gcctgctcta tgcttctggt ggagcgagag tagatggcca cctcttagtg
      301 actcgtttgc tggaagccag tcaggtcaag ctggtcaaag aaaaagtgac tctgacaccg
      361 ttagcatcag gctaccagat tggtgaagag gagtttgagc aggttatttt ggcgacggga
      421 gcttggttgg gggacatgtt agaacccttg ggttatgaag tagatgttcg tcctcaaaaa
      481 ggacaactac gagattatca gctggtccaa gacatggaag cttaccctgt tgtcatgcca
      541 gaaggggagt gggatttgat tccttttgca ggtgggaaat tgtccttagg cgctacccac
      601 gaaaatgaca tgggatttga tttgacggta gatgaaacct tgctccaaca aatggaggag
      661 gccaccttga ctcactatct gattttggct gaagctactt caaaatctga gcgtgttgga
      721 atccgtgcct acaccagtga tttctc
//
LOCUS       DBMVGT010000212          744 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.212, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000212 DBMVGT010000000
VERSION     DBMVGT010000212.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 744)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 744)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.212"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            269..>744
                     /gene="galR"
                     /locus_tag="AC0DU4_002261"
     CDS             269..>744
                     /gene="galR"
                     /locus_tag="AC0DU4_002261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000212522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding transcriptional regulator GalR"
                     /protein_id="HIN4238147.1"
                     /translation="MATLKDIAQLASVSIATVSRVLNRDQSLSVTEETRHRILTVAEE
                     LGYTKHLKTGESHKPKQKIAIIQWVSEQGELDDLYYYQIRLGIEKRAQELDYDILRYF
                     NDHPFTLSEEVIGILCIGKFSRAQISAFEEYQKPLVFLDSDTLSLGHTCIITDFYTA"
BASE COUNT          227 a          168 c          147 g          202 t
ORIGIN      
        1 atcaaattaa tgcggcctgg tgaaaagaag gtttggtctg cttcttgacc aaaaacagca
       61 agaaagtctt tgcgaagggc ttcagtagta agatgttgtg ccatatgaat tctcctttga
      121 ctgtccgtta agccatctta acgtgtaatc gttttctttc tattgtatcc aaggaatttt
      181 ccaaggtcaa tcctttttac taaaatttta gtaaaatatc agtaaaaaga agaaaaacat
      241 gatatactaa cctaatcaag gaggatttat ggctacctta aaagacattg cacagctagc
      301 ctctgtctct atcgcgaccg tatcccgcgt cctcaatcgc gaccagagcc tatctgttac
      361 agaagaaacc agacaccgta ttttaaccgt tgctgaagag ctgggctaca ccaagcacct
      421 caagacaggc gagtcccaca aacccaagca aaagattgcc attatccaat gggtcagcga
      481 acaaggggag ctggacgacc tctactacta ccagattcgc ctaggaatag aaaaaagagc
      541 ccaagagttg gactatgata tcttgcgcta ttttaatgac caccctttta ccctaagcga
      601 ggaagtgatt gggattctct gcatcggaaa gtttagtcga gctcagattt ctgcctttga
      661 agaataccaa aagcctcttg tatttctaga cagcgataca ctttccctgg gacatacctg
      721 tattatcacg gatttttaca ctgc
//
LOCUS       DBMVGT010000213          729 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.213, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000213 DBMVGT010000000
VERSION     DBMVGT010000213.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 729)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 729)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..729
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.213"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>729
                     /locus_tag="AC0DU4_002262"
     CDS             <1..>729
                     /locus_tag="AC0DU4_002262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001063457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HIN4238148.1"
                     /translation="GDSGSKGLADILKPALSRGELTVIGATTQDEYRNTILKNAALAR
                     RFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDK
                     AIDLVDVTAAHLAAQHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELE
                     RKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGASDIERLKDMAHRLQDKVIGQDK
                     AVEAVARAIRRNRAGFDEGNRPIG"
BASE COUNT          230 a          151 c          175 g          173 t
ORIGIN      
        1 gtggagacag tggttctaaa gggcttgcgg atattctcaa gccagctctc tctcgtggag
       61 aattgacagt gattggggca acaactcaag acgaataccg taacaccatc ttgaagaatg
      121 ctgctcttgc tcgtcgtttc aacgaagtga aggtcaatgc tccttcagca gagaatactt
      181 ttaaaattct tcaaggcatt cgtgacctct atcaacaaca ccacaatgtc atcttgccag
      241 acgaagtctt gaaagcagcg gtggattatt ctgttcaata cattcctcaa cgtagcttgc
      301 cagataaggc tattgacctt gtcgatgtaa cggctgctca cttggcggct caacatccag
      361 taacagatgt gcatgctgtt gaacgagaaa tcgaaacgga aaaagacaag caagaaaaag
      421 cagttgaagc agaagatttt gaagcagctc taaactataa aacacgcatt gcagaattgg
      481 aaaggaaaat cgaaaaccac acagaagata tgaaagtgac tgcaagtgtc aacgatgtgg
      541 ctgaatctgt ggaacgaatg acaggtatcc cagtatcgca aatgggagct tcagatatcg
      601 aacgtttgaa agatatggct catcgcttgc aagacaaggt gattggtcaa gataaggccg
      661 tagaagctgt agctcgtgct atccgtcgta accgtgctgg ttttgatgaa ggaaatcgcc
      721 caatcggca
//
LOCUS       DBMVGT010000214          724 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.214, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000214 DBMVGT010000000
VERSION     DBMVGT010000214.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 724)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.214"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(150..494)
                     /locus_tag="AC0DU4_002263"
     CDS             complement(150..494)
                     /locus_tag="AC0DU4_002263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4238149.1"
                     /translation="MVSSKHAARASFLDGQGITVDEMSWIIRGIVTGLIGGHIKLGAY
                     AAKYGISIARSILSRAAATAAARVGLLTKISGRILQIAVNVADVYGNFAYNIAAAWDA
                     HDKIPNNGRINF"
     gene            complement(591..>724)
                     /locus_tag="AC0DU4_002264"
     CDS             complement(591..>724)
                     /locus_tag="AC0DU4_002264"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HIN4238150.1"
                     /translation="EHYPLLLGYHNFAIFFPGEPHQPTGYAGMEEKVRKYLFKILID"
BASE COUNT          233 a          162 c          104 g          225 t
ORIGIN      
        1 atgtatatat agcgaggaca acgcactagc taaaatatta cgccaagtgt gttcatcaaa
       61 tccatttatt cctccacgga ttatcattgc aagcactgtc caagctaaca tatacaataa
      121 aaaatacaaa gtgctttcat tctcgcattt taaaagttta tacgaccatt gttagggatt
      181 ttatcatgtg catcccaagc tgcagcaata ttgtaggcaa aattaccata tacatcagct
      241 acattcacag ctatttgtaa aatccttcca gaaatcttgg tcagtaatcc tactcttgct
      301 gctgcagttg cagctgccct acttaagatc gatcgtgcta tactaatacc atacttagct
      361 gcataagcac ctaattttat gtgtccgcca atcaatccag tcacaatgcc cctaattatc
      421 caggacatct catcaactgt aattccctgt ccatctaaga aactagctct tgcagcatgc
      481 ttagaagata ccaattttta aatattttat tctcatttct ctacctcaca aagatcaatt
      541 tcatggtaga gtattgtcaa agctttacaa aaaaacaatt catcctattt ttaatcaatc
      601 aaaattttaa agagatattt ccgaaccttt tcttccatgc ctgcataacc agttggctga
      661 tgtggctcac ctgggaagaa aatcgcaaaa ttgtgataac ccaacaagag tgggtagtgt
      721 tcat
//
LOCUS       DBMVGT010000215          724 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.215, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000215 DBMVGT010000000
VERSION     DBMVGT010000215.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 724)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.215"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..432
                     /locus_tag="AC0DU4_002265"
     CDS             <1..432
                     /locus_tag="AC0DU4_002265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HIN4238151.1"
                     /translation="MSKYLMNREVGFGRKVLQILEELNIGWEHMPTGIDDLSIILRSR
                     ELTPIKEEEILRQLVQKTKVDHAEIEHDLSIIMIVGEKMKSHIGVTATATRALSENKI
                     NIQMMSQGSSEVSIMFVVNKDQEKAAIKALYNAFFGKSKED"
     gene            435..>724
                     /locus_tag="AC0DU4_002266"
     CDS             435..>724
                     /locus_tag="AC0DU4_002266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF956 family protein"
                     /protein_id="HIN4238152.1"
                     /translation="MAQSLNKTVLLSTTGTSYLSIAGKVGKFLVGDQALEFYPDVNVE
                     QFIQIPWSHINQIGANVTGRKISRHFEVFTDKGKFLFASKDSGAILKIAREKL"
BASE COUNT          232 a          163 c          144 g          185 t
ORIGIN      
        1 atgtcgaaat acctcatgaa ccgtgaggtt ggatttggcc gcaaggttct gcaaatcctg
       61 gaagaactta acatcggttg ggaacatatg ccaacaggta tcgacgatct ttctatcatt
      121 ctccgttctc gcgaactaac tcccatcaag gaagaagaaa tcctgcgtca gttggttcaa
      181 aagactaaag tagatcatgc agaaatcgaa cacgaccttt ctatcattat gattgttggt
      241 gaaaaaatga agagccacat cggagtgact gctactgcga cacgcgctct atctgaaaac
      301 aaaatcaaca tccagatgat gtctcaaggt tctagtgaag tttctatcat gtttgttgtc
      361 aataaagacc aagagaaagc agcaattaaa gccctctaca atgccttttt tggaaaaagt
      421 aaggaagact aagcatggcc caatcactta acaaaacagt actcctcagt acgacaggca
      481 cttcctacct ctctatcgct gggaaagttg ggaaattcct tgtcggagat caggctttgg
      541 aattttaccc agatgtcaat gtcgaacaat ttatccagat tccttggagc catatcaatc
      601 agattggagc caatgtcact ggacgcaaaa tcagccgcca cttcgaagtc tttacagaca
      661 aaggaaaatt cctctttgct tcaaaagact caggtgccat tctcaaaatt gcacgcgaaa
      721 aact
//
LOCUS       DBMVGT010000216          722 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.216, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000216 DBMVGT010000000
VERSION     DBMVGT010000216.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 722)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 722)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.216"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..507
                     /gene="nrdG"
                     /locus_tag="AC0DU4_002267"
     CDS             <1..507
                     /gene="nrdG"
                     /locus_tag="AC0DU4_002267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001064213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA];
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HIN4238153.1"
                     /translation="DGEGVRNSLYVSGCMFHCEGCYNVATWSFNAGILYTAELEEQIM
                     ADLAQPYVQGLTLLGGEPFLNTGILLPLVKRIRKELPDKDIWSWTGYTWEEMMLETPD
                     KLELLSLIDILVDGRYDRTKRNLMLQFRGSSNQRIIDVQKSLKSGQVVIWDKLNDGKE
                     SYEQVKRE"
     gene            504..>722
                     /locus_tag="AC0DU4_002268"
     CDS             504..>722
                     /locus_tag="AC0DU4_002268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4238154.1"
                     /translation="MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTFAQELYQALD
                     STTVNLLETDPYITSGRHLVVPKDAPNQK"
BASE COUNT          220 a          141 c          177 g          184 t
ORIGIN      
        1 gatggcgaag gcgtgcgtaa ctctctctat gtatcaggct gtatgtttca ctgcgaggga
       61 tgttataatg ttgcgacttg gtcttttaat gctggcattc tctatacagc agaattagaa
      121 gagcagatta tggcagacct tgcccaaccc tatgttcaag gcttgacttt gctgggaggg
      181 gagccttttc ttaatactgg cattctcttg cctctagtta aacgcatccg aaaggaattg
      241 ccagacaagg acatttggtc ctggaccggc tacacttggg aagaaatgat gttggaaact
      301 ccagataaac tggaactctt gtcactgatt gacattcttg tcgatggaag atatgatcga
      361 actaagagaa atcttatgct ccagtttcga ggttcgtcta accaacgaat tatcgatgtg
      421 caaaaatcgc tcaaaagtgg gcaagtagtg atttgggaca agctcaatga cggaaaagaa
      481 agctatgaac aggtgaagag agaatgaaga aaaaggactt agtagaccaa ctagtctcag
      541 agatcgagac ggggaaagtc aggacactgg gaatatacgg tcatggagct tcaggtaaat
      601 caacctttgc acaggaattg taccaagctt tagattctac tacagtaaat ttgctagaga
      661 cagatcctta tatcacctca ggacgccatc tggtagtacc caaggacgcg ccgaatcaaa
      721 ag
//
LOCUS       DBMVGT010000217          720 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.217, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000217 DBMVGT010000000
VERSION     DBMVGT010000217.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 720)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 720)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.217"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            23..289
                     /locus_tag="AC0DU4_002269"
     CDS             23..289
                     /locus_tag="AC0DU4_002269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001234972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HIN4238155.1"
                     /translation="MRLDKYLKVSRIIKRRTVAKEVADKGRIKVNGILAKSSTDLKVN
                     DQVEIRFGNKLLLVKVLEMKDSTKKEDAAGMYEIISETRVEENV"
     gene            282..650
                     /locus_tag="AC0DU4_002270"
     CDS             282..650
                     /locus_tag="AC0DU4_002270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HIN4238156.1"
                     /translation="MSKNIVQLNNSFIQNEYQRRRYLMKERQKRNRFMGGVLILIMLL
                     FILPTFNLAQSYQQLLQRRQQLADLQTQYQTLSDEKDKETAFATKLKDEDYAAKYTRA
                     KYYYSKSREKVYTIPDLLQR"
     gene            655..>720
                     /locus_tag="AC0DU4_002271"
     CDS             655..>720
                     /locus_tag="AC0DU4_002271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0009 family protein"
                     /protein_id="HIN4238157.1"
                     /translation="MENLLDVIEQFLSLSDEKLEEL"
BASE COUNT          275 a           91 c          154 g          200 t
ORIGIN      
        1 ataataaatt gaggtaataa ggatgagatt agataaatat ttaaaagtat cgcgaattat
       61 caagcgtcgt acagtcgcaa aggaagtagc agataaaggt agaatcaagg ttaatggaat
      121 cttggccaaa agttcaacgg acttgaaagt taatgaccaa gttgaaattc gctttggcaa
      181 taagttgctg cttgtaaaag tactagagat gaaagatagt acaaaaaaag aagatgcagc
      241 aggaatgtat gaaattatca gtgaaacacg ggtagaagaa aatgtctaaa aatattgtac
      301 aattgaataa ttcttttatt caaaatgaat accaacgtcg tcgctacctg atgaaagaac
      361 gacaaaaacg gaatcgtttt atgggggggg tattgatttt gattatgcta ttatttatct
      421 tgccaacttt taatttggcg cagagttatc agcaattact ccaaagacgt cagcaattag
      481 cagacttgca aactcagtat caaactttga gtgatgaaaa ggataaggaa acagcatttg
      541 ctaccaagtt gaaagatgaa gattatgctg ctaaatatac acgagcgaag tactattatt
      601 ctaagtcgag ggaaaaagtt tatacgattc ctgacttgct tcaaaggtga taaaatggaa
      661 aatttattag acgtaataga gcaatttttg agtttgtcag atgaaaagct ggaagaattg
//
LOCUS       DBMVGT010000218          720 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.218, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000218 DBMVGT010000000
VERSION     DBMVGT010000218.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 720)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 720)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.218"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            166..>720
                     /locus_tag="AC0DU4_002272"
     CDS             166..>720
                     /locus_tag="AC0DU4_002272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-amylase family glycosyl hydrolase"
                     /protein_id="HIN4238158.1"
                     /translation="MQNQTLMQYFEWYLPHDGQHWTRLAEDAPHLAHLGISHVWMPPA
                     FKATNEKDVGYGVYDLFDLGEFNQKGTVRTKYGFKEDYLQAIQALKAQGIQPMADVVL
                     NHKAAADHMEAFQVIEVDPVDRTVKLGEPFTINGWTSFTFDGRQDTYNDFHWHWYHFT
                     GTDYDAKRRKSGIYLIQGDNKGWAN"
BASE COUNT          225 a          166 c          145 g          184 t
ORIGIN      
        1 ctttatctat attaaatact attatactag cactttgata caaaaaaatc aacactttat
       61 tttaagtaga tacaatagtt tccttctatt cttacgcaaa cgtttgcgct aaccaatact
      121 ttatgataga ataaagaaca agattgacaa gtaagaggaa aaatcatgca aaatcaaacg
      181 ctcatgcaat actttgaatg gtatctgccc cacgacggtc agcactggac gcgtctggct
      241 gaagatgctc cacacctagc tcatctgggg attagccacg tctggatgcc accagctttt
      301 aaggcaacca atgaaaaaga tgtcggctat ggtgtctatg acttatttga cctaggagag
      361 tttaaccaaa aagggactgt ccgcaccaag tatggtttca aagaagacta tcttcaagcc
      421 attcaagccc taaaagcaca gggaattcaa cctatggccg atgtggttct caatcacaag
      481 gctgcagccg atcacatgga agcctttcag gttatcgaag tggatcctgt agaccgtacg
      541 gttaaacttg gagaaccctt caccatcaat ggctggacta gctttacctt cgatggtcgc
      601 caagatacct acaatgactt ccactggcat tggtaccact tcaccggtac agactacgat
      661 gcaaaacgcc gtaagtctgg gatttatctc atccaagggg acaacaaggg ctgggctaac
//
LOCUS       DBMVGT010000219          714 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.219, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000219 DBMVGT010000000
VERSION     DBMVGT010000219.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 714)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 714)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.219"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>714)
                     /locus_tag="AC0DU4_002273"
     CDS             complement(<1..>714)
                     /locus_tag="AC0DU4_002273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="HIN4238159.1"
                     /translation="DFFNPSFREAYFKDVHYELEKQGVDFWWIDWQQGTQGMLDSLWL
                     LNHYHYQDSCKNAEGGLTLSRYAGPGSHRYPVGFSGDTIISWNSLRFQPYFTATASNI
                     GYSWWSHDIGGHMLGDYDEELQTRWLQFGVFSPITRLHSSRSPFNSKEPWFFSETTSK
                     IMKKYLRLRHQMIPYLYTMNVQTHEEGAPLISPIYYFYPENDESYNVPNQYFFGTELM
                     VAPIVEKMDLTFQSAKVDV"
BASE COUNT          232 a          150 c          116 g          216 t
ORIGIN      
        1 catacatcta cttttgcaga ttggaatgtc aaatccatct tttctacaat gggagccacc
       61 atcagttctg ttccaaaaaa gtattggttt ggaacattat agctctcatc attctctgga
      121 tagaaataat agattggact gattaatggg gcaccttcct catgtgtctg tacattcatg
      181 gtatatagat agggaatcat ctgatgtctc aaacgaaggt atttcttcat aatcttagat
      241 gttgtttctg aaaaaaacca aggttcttta ctattaaaag gacttctaga actatgtaat
      301 cgagtaatcg gactaaaaac accaaactgt agccatctag tttgtagctc ttcgtcataa
      361 tcccccaaca tatgtccacc gatatcatga ctccaccaac tataaccgat attagatgct
      421 gtcgctgtaa aatagggttg aaatcttaag gaattccaac taataatagt atcccctgaa
      481 aaaccaacag ggtagcggtg actaccagga cctgcatatc ttgataaagt caaaccacct
      541 tctgcatttt tacaactatc ctgatagtga taatggttta aaagccaaag tgaatctagc
      601 ataccttgtg tcccttgttg ccagtcaatc caccaaaaat ctactccctg cttttctagc
      661 tcataatgaa catctttaaa gtaggcttcc ctaaaagagg gattaaaaaa atca
//
LOCUS       DBMVGT010000220          707 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.220, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000220 DBMVGT010000000
VERSION     DBMVGT010000220.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 707)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 707)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.220"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>707
                     /locus_tag="AC0DU4_002274"
     CDS             <1..>707
                     /locus_tag="AC0DU4_002274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HIN4238160.1"
                     /translation="YSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHM
                     NPCGIGQADDIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSY
                     TDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQV
                     VTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQA
                     KDRLDGAVLASDAFFPFA"
BASE COUNT          188 a          169 c          172 g          178 t
ORIGIN      
        1 tactccattg cttcagccaa acagctcaac gggaaagaat tgtcatttaa taatatccgt
       61 gatgcagatg ctgctatccg tatcatccgt gacttcaaag atagtccaac cgttgtggct
      121 ctcaaacaca tgaatccatg tggaattggt caagctgatg acatcgagac tgcttgggac
      181 tacgcttatg agtctgaccc agtgtctatc tttggtggga ttgtcgtcct caaccgtgag
      241 gtggatgctg cgacagctga gaagatgcac ggcgttttcc tcgaaatcat cattgcacca
      301 agctatacgg atgaagcgct agccattttg atcaataaaa agaaaaactt gcgtatcctt
      361 gccttgccat ttaatgctca agaggctagc gaagtggaag cagaatacac aggtgtagtc
      421 ggtggacttc tcgtgcaaaa tcaagacgtg gtcaaggaaa gcccagctga ctggcaagtg
      481 gtgaccaaac gtcagccaac cgagacagaa gcgactgctc ttgagttcgc ttggaaggct
      541 atcaagtacg tcaaatcaaa tggtattatc gtgaccaacg accacatgac acttggtgtt
      601 ggtccaggtc aaaccaaccg tgtggcttct gttcgccttg ccattgacca agccaaagat
      661 cgtctggacg gggcggtcct tgcttcagat gccttcttcc catttgc
//
LOCUS       DBMVGT010000221          704 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.221, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000221 DBMVGT010000000
VERSION     DBMVGT010000221.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 704)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 704)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.221"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..250
                     /locus_tag="AC0DU4_002275"
     CDS             <1..250
                     /locus_tag="AC0DU4_002275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="aldose epimerase"
                     /protein_id="HIN4238161.1"
                     /translation="LYDQNSGRFLLFKTEAPCFVVYTANFVDESVIIGGQPMLQHNGI
                     ALEAQALPDAIHSDLKGQVILKAGQTFTSKTRYELVVK"
     gene            457..>704
                     /locus_tag="AC0DU4_002276"
     CDS             457..>704
                     /locus_tag="AC0DU4_002276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HIN4238162.1"
                     /translation="MTYEYKSHIYLAETVLNVKDLASQTAFYQQVIGLEILSQTETES
                     ILGLGGKVLVQLIQAQESGEVREHYGLYHLAILLPTRKA"
BASE COUNT          223 a          125 c          142 g          214 t
ORIGIN      
        1 cctttatgac caaaattcag gtcgcttcct gcttttcaag acagaagctc cttgctttgt
       61 ggtctacaca gcaaactttg tggatgaaag tgtcatcata ggaggtcagc caatgctaca
      121 gcacaatggg attgctcttg aagcgcaagc tttaccagat gccattcaca gtgaccttaa
      181 aggccaagtc attcttaaag ctggtcaaac cttcaccagt aagacacgtt atgaacttgt
      241 tgtgaaataa aaaagctggt caaaaagtct ttaaaattaa aataacgcat attgtcaggt
      301 gatgaaaagt ttgatactat gcgttttatt atgaaatgat ttactttatc ttatcctgaa
      361 atggtgttat ttttgagtta tctggcttga ctttcttgat ggaaattata taatagttgt
      421 aataacaata attacaacga gaaaagagga ccatttatga cctatgaata caagagtcac
      481 atttatttgg cagagacagt tttaaatgta aaggatttgg ccagtcaaac agccttttat
      541 cagcaagtta ttggtttaga aatcttatct caaactgaga cagagtccat tctaggcctt
      601 ggtggaaaag tcttggtaca gctgattcaa gcacaagaga gcggagaagt gagggaacat
      661 tatggtcttt accatttggc cattctcttg cccacacgca aggc
//
LOCUS       DBMVGT010000222          699 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.222, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000222 DBMVGT010000000
VERSION     DBMVGT010000222.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 699)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 699)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.222"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>699
                     /locus_tag="AC0DU4_002277"
     CDS             <1..>699
                     /locus_tag="AC0DU4_002277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HIN4238163.1"
                     /translation="DLGANFEYDLPKDKFRQARIARQVRVTIPVHLAPLSWTTFQLLE
                     GKQEHREGIYQNGVIDTPFVTVSVDDNITVYDKTTHEAYEDFIRFEDRGDIGNEYIYF
                     QPKGTEPIFAELKGHEVLENTACYAKILLKHELTVPVSADEKLEEEQQGIIEFMKREA
                     GRSEELTNIPLETELTVFVDNPQIRFKTRFTNTAKDHRIRLLVKTHNTRPSNDSESIY
                     EVVTRPNKPAASWE"
BASE COUNT          220 a          162 c          156 g          161 t
ORIGIN      
        1 agacctcgga gctaattttg agtatgattt accaaaagac aagttccgcc aagctcgtat
       61 tgctcgtcaa gtgcgcgtga ccattccagt tcacctagcg ccgctttctt ggacaacctt
      121 ccaattgctg gaaggaaaac aagaacaccg tgagggtatt taccaaaacg gagtgattga
      181 tacaccattc gtaacggtga gtgtggatga caacatcaca gtctatgaca agacaactca
      241 cgaagcctat gaagacttta tccgctttga agaccgtggg gacatcggaa acgagtatat
      301 ctatttccaa ccaaaaggaa cagagccaat ctttgcagaa cttaagggcc acgaggtctt
      361 ggaaaacaca gcttgctatg ctaaaatctt gctcaaacat gaattgaccg tgcctgtcag
      421 cgcggatgaa aagctagaag aagagcaaca aggtatcatc gagtttatga agcgtgaggc
      481 tggacggtca gaagaattga caaacattcc tctggaaact gagttgactg tcttcgttga
      541 caatccacaa atccgcttca agactcgctt tactaacact gccaaggatc accgtatccg
      601 tctcttggtc aagactcata acacgcgtcc aagcaatgat tctgaaagta tctatgaggt
      661 ggtgacacga ccaaacaaac cagctgcttc atgggaaaa
//
LOCUS       DBMVGT010000223          696 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.223, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000223 DBMVGT010000000
VERSION     DBMVGT010000223.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 696)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 696)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.223"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>696
                     /locus_tag="AC0DU4_002278"
     CDS             <1..>696
                     /locus_tag="AC0DU4_002278"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002310842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004521 - RNA endonuclease activity
                     [Evidence IEA];
                     GO_function: GO:0004534 - 5'-3' RNA exonuclease activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HIN4238164.1"
                     /translation="PLGIVIHTPQGKIICTGDFKFDFTPVGEPADLHRMAALGEDGVL
                     CLLSDSTNAEVPTFTNSEKVVGQSIMKIIQGIEGRIIFASFASNIFRLQQATEAAVKT
                     GRKIAVFGRSMEKAIVNGIDLGYIKAPKGTFIEPNEIKDYPAGEILILCTGSQGEPMA
                     ALSRIANGTHRQVQLQPGDTVIFSSSPIPGNTTSVNKLINIISEAGVEVIHGKVNNIH
                     TSGHGGQQEQKLML"
BASE COUNT          188 a          178 c          151 g          179 t
ORIGIN      
        1 cctttgggaa ttgtcatcca tactcctcaa gggaaaatca tctgtacagg tgactttaag
       61 ttcgacttta ctccagttgg agaacctgcg gacttgcacc gtatggcagc cctaggtgaa
      121 gatggagtgc tttgcttgct ctctgactcg accaatgctg aggttccaac ctttacaaac
      181 tctgaaaagg ttgtcggcca gtccatcatg aagattatcc aaggtatcga gggacgtatc
      241 atctttgcat ccttcgcctc aaatatcttc cgtctccaac aagcaacgga agctgctgtt
      301 aagactgggc gcaagattgc ggtctttggt cgctctatgg aaaaggccat tgtcaacgga
      361 atcgatcttg gctacatcaa agctcctaag ggaaccttta ttgagccaaa tgaaatcaaa
      421 gactatcctg caggtgagat tctgatcctc tgtacaggta gtcaaggtga acctatggca
      481 gccctctctc gtatcgccaa cggaacccac cgtcaggtac aactccaacc aggcgatacc
      541 gttatcttct cttctagtcc catccctgga aacactacta gcgtcaacaa gctgattaac
      601 atcatttctg aagctggtgt cgaagttatc cacggtaaag tgaacaatat ccatacatct
      661 ggacacggtg gtcagcaaga gcaaaaactc atgctc
//
LOCUS       DBMVGT010000224          696 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.224, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000224 DBMVGT010000000
VERSION     DBMVGT010000224.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 696)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 696)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.224"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>696
                     /locus_tag="AC0DU4_002279"
     CDS             <1..>696
                     /locus_tag="AC0DU4_002279"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002310842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0004521 - RNA endonuclease activity
                     [Evidence IEA];
                     GO_function: GO:0004534 - 5'-3' RNA exonuclease activity
                     [Evidence IEA];
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA];
                     GO_process: GO:0006364 - rRNA processing [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HIN4238165.1"
                     /translation="PLGIVIHTPQGKIVCTGDFKFDFTPVGEPADLHRMAALGEEGVL
                     CLLSDSTNAEVPTFTNSEKVVGQSIMKIIQGIEGRIIFASFASNIFRLQQATEAAVKT
                     GRKIAVFGRSMEKAIVNGIDLGYIKAPKGTFIEPNEIKDYPAGEVLILCTGSQGEPMA
                     ALSRIANGTHRQVQLQPGDTVIFSSSPIPGNTTSVNKLINIISEAGVEVIHGKVNNIH
                     TSGHGGQQEQKLML"
BASE COUNT          188 a          169 c          153 g          186 t
ORIGIN      
        1 cctttgggga ttgtcattca tactcctcaa gggaaaatcg tctgtacggg tgactttaag
       61 ttcgacttta ctccagttgg agaacctgcg gacttgcatc gtatggctgc gcttggtgaa
      121 gaaggcgtgc tctgtctcct gtctgactcg acaaatgcgg aagtaccaac ctttaccaac
      181 tctgaaaaag tcgttggtca gtccattatg aagattatcc aaggtattga aggacgtatc
      241 atctttgcat cctttgcctc aaatatcttc cgtctccagc aggcaacaga agctgctgtt
      301 aagactggac gcaagattgc ggtctttggt cgttctatgg aaaaggccat tgtcaacgga
      361 atcgatcttg gctacatcaa agctcctaag ggaaccttta tcgagccaaa tgaaatcaaa
      421 gattatcctg caggagaagt tcttatcctc tgtacaggta gtcagggtga gcctatggca
      481 gccctctctc gtatcgccaa cggaacccac cgtcaagtac aattacaacc aggtgatacc
      541 gttatcttct cttctagtcc catccctgga aacactacta gcgtcaacaa gctgattaac
      601 atcatttctg aagctggtgt cgaagttatc cacggtaaag tgaacaatat ccatacatct
      661 ggacacggtg gtcagcaaga gcaaaaactc atgctc
//
LOCUS       DBMVGT010000225          691 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.225, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000225 DBMVGT010000000
VERSION     DBMVGT010000225.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 691)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 691)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.225"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..673
                     /gene="pyrH"
                     /locus_tag="AC0DU4_002280"
     CDS             <1..673
                     /gene="pyrH"
                     /locus_tag="AC0DU4_002280"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000013002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0005737 - cytoplasm [Evidence IEA];
                     GO_function: GO:0033862 - UMP kinase activity [Evidence
                     IEA];
                     GO_process: GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA];
                     GO_process: GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HIN4238166.1"
                     /translation="GVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRGEPAAEA
                     GMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRALRHLE
                     KGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILMAKNGVDGVYNADPKKDKTAVKF
                     EELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQSGNIKRVVFGENIGTTVSNN
                     IEEKE"
BASE COUNT          210 a          141 c          167 g          173 t
ORIGIN      
        1 tggcgtaggg attgatatcc aaacagttca aacaatcgca aaagagattc aagaagttca
       61 tagcttaggt atcgaaattg cccttgttat tggtggagga aatctctggc gtggagaacc
      121 tgcagcagaa gcaggtatgg accgtgttca ggcagattac actggaatgc ttgggactgt
      181 tatgaatgct cttgtgatgg cagattcatt gcaacaagtt ggggttgata cgcgtgtaca
      241 aacagctatt gctatgcaac aagtggcaga gccttatgtc cgtggacgtg cccttcgtca
      301 ccttgaaaaa ggccgtatcg ttatctttgg tgctggaatt ggttcaccat acttctcgac
      361 agatacaaca gcggcccttc gtgcagctga aatcgaagca gatgccatcc tcatggctaa
      421 aaatggcgtc gatggtgtgt acaatgccga tcctaagaag gacaagacag ccgttaagtt
      481 tgaagaattg acccaccgtg atgttatcaa caaaggtctt cgtatcatgg actcaacagc
      541 ctcaaccctc tcaatggaca acgacattga cttggttgtc ttcaacatga accaatcagg
      601 caacatcaaa cgtgtcgtat ttggtgaaaa tatcggaaca acagtttcaa ataatatcga
      661 agaaaaggaa taagaaagaa tatggctaac g
//
LOCUS       DBMVGT010000226          690 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.226, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000226 DBMVGT010000000
VERSION     DBMVGT010000226.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 690)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 690)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.226"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..196)
                     /locus_tag="AC0DU4_002281"
     CDS             complement(<1..196)
                     /locus_tag="AC0DU4_002281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1304 domain-containing protein"
                     /protein_id="HIN4238167.1"
                     /translation="MSIILTTIVALEHFYIFYLESIATQSDATSRVFNMEKEELAHPS
                     VSSLFKNQGIYKALLGVFLLY"
     gene            complement(207..632)
                     /locus_tag="AC0DU4_002282"
     CDS             complement(207..632)
                     /locus_tag="AC0DU4_002282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000890080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="HIN4238168.1"
                     /translation="MLEIQDLLYQLRLSEQASTQLFEKRLGISLTRYQILLFLLEHSP
                     CNQMAVQERLKIDQAALTRHFKILETEGLVERHRNPENQREVLVEAAKYAKEQLVVNP
                     PLQHIRVKEEIESILTEFERTELSRLLNKLVLGIENIEI"
BASE COUNT          212 a          161 c           97 g          220 t
ORIGIN      
        1 catacaagag aaagactcct agcagagcct tataaattcc ttgatttttg aacaatgaac
       61 ttactgacgg atgagccaat tcttcctttt ccatattaaa tacacgacta gtcgcatctg
      121 attgcgtggc aatactttcc aaataaaaaa tgtaaaaatg ctccaaagca acgatcgttg
      181 ttaaaataat tgacatctat ttctccttaa atttctatat tttcaatacc caaaaccaat
      241 ttatttaata aacggctgag ttctgttctc tcaaactctg ttaagatact ttctatctct
      301 tccttaaccc tgatatgttg cagaggggga ttcaccacta actgctcctt ggcatacttc
      361 gcagcctcta ccaacacttc ccgctgattt tcaggattac gatgacgctc caccaaacct
      421 tccgtttcca aaattttgaa atgccgtgtc aaagcagcct gatcaatttt caaacgctcc
      481 tgaaccgcca tttggttaca aggagaatgc tccagcaaaa acagtaaaat ctgataccgt
      541 gtcaaactaa tcccaagcct tttttcaaac aattgcgtac tcgcttgctc agacaagcgg
      601 agttgataca gtaaatcttg aatctctagc atttcttccc ctctcttttt attgatttat
      661 caatatttga ctaattaatt gtgatataaa
//
LOCUS       DBMVGT010000227          671 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.227, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000227 DBMVGT010000000
VERSION     DBMVGT010000227.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 671)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 671)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.227"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..515
                     /locus_tag="AC0DU4_002283"
     CDS             <1..515
                     /locus_tag="AC0DU4_002283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="NIL domain-containing protein"
                     /protein_id="HIN4238169.1"
                     /translation="TKQILALLQDLNQKLGLTVVLITHEMQIVKDIANRVAVMQDGHL
                     IEESSVLEIFSDPKQPLTQDFISTATGIDEAMVKIEKQEIVEHLSENSLLVQLKYAGS
                     STDEPLLNELYKHYQVMANILYGNIEILDGTPVGELVVVLSGEKAALAGAQEAIRQAG
                     VQLKVLKGGQ"
     gene            517..>671
                     /locus_tag="AC0DU4_002284"
     CDS             517..>671
                     /locus_tag="AC0DU4_002284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4238170.1"
                     /translation="MESLIQTYLPNVYKMGWSGQAGWGTAIYLTLYMTVLSFIIGGFL
                     GLVAGLFL"
BASE COUNT          194 a          130 c          160 g          187 t
ORIGIN      
        1 caaccaagca gattttggcc ttgttgcaag atttgaacca aaaattaggc ttgactgttg
       61 tcctgattac gcatgaaatg cagattgtca aagacattgc caaccgtgtt gcagttatgc
      121 aggatgggca tttgattgaa gagagtagtg tgcttgaaat cttctcagac cctaaacaac
      181 ctttgactca agactttatc tcaacagcta caggtattga cgaagccatg gtcaaaatcg
      241 agaagcaaga aatcgtggaa cacttgtctg aaaacagtct cttggtgcaa ctcaagtacg
      301 ctggatcttc aacagacgag ccacttttga atgaattgta caagcattat caagtaatgg
      361 ctaatattct ctatgggaat atcgaaatcc tcgatggtac tcctgttgga gaattggtgg
      421 tggtcttgtc aggtgaaaaa gcagcgctgg caggtgctca agaagccatt cgtcaagcag
      481 gcgtacagtt aaaagtattg aagggaggac agtaagatgg aatcattgat tcaaacctat
      541 ttaccaaatg tctataagat gggttggtct ggtcaggcag gctggggaac agctatctac
      601 ctaaccctct atatgacagt tctttccttc attatcggag gcttcttggg gctagtggca
      661 ggtctctttc t
//
LOCUS       DBMVGT010000228          668 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.228, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000228 DBMVGT010000000
VERSION     DBMVGT010000228.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 668)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 668)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.228"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>668
                     /locus_tag="AC0DU4_002285"
     CDS             <1..>668
                     /locus_tag="AC0DU4_002285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HIN4238171.1"
                     /translation="RHLRLMEEELDVVIHARTEIVQVLGEESACEEARQVIQALMVLV
                     NRGMTVGTPDVVTAISMVKNDEIDKFVALYEEEIIKDNTGKPIRVKTLGQKLYVDSVK
                     QHDVTFGIGPAGTGKTFLAVTLAVTALKRGQVKRIILTRPAVEAGESLGFLPGDLKEK
                     VDPYLRPVYDALYQILGKDQTTRLMEREIIEIAPLAYMRGRTLDDAFVILDEAQNTTI
                     MQMK"
BASE COUNT          177 a          130 c          184 g          177 t
ORIGIN      
        1 cgccatcttc gtttgatgga agaagagctg gatgtggtga ttcatgctcg tacggagatt
       61 gtccaggttt tgggagaaga gtctgcttgt gaggaagccc gtcaggttat tcaagctctc
      121 atggtcttgg tgaaccgtgg gatgaccgtt ggtacgccag atgtggtaac tgcaattagc
      181 atggtcaaaa acgatgaaat tgataagttt gtcgcccttt acgaagaaga aattatcaaa
      241 gataatactg ggaaaccgat ccgcgtcaaa accttaggtc aaaaacttta tgtggacagt
      301 gtcaaacagc atgatgtgac ctttggaatt gggcctgcag ggacggggaa gacctttctt
      361 gcagttactt tggcagtgac tgcccttaaa cgtgggcaag tcaagcggat tatcttgaca
      421 cgtccagcgg tggaagcagg agagagtcta ggttttcttc cgggtgatct taaggagaag
      481 gtagatcctt accttagacc tgtttatgat gccttgtatc agattctggg gaaagaccaa
      541 acaactcgac tcatggagcg tgaaattatc gagattgcgc cccttgccta tatgcgtgga
      601 cggaccttgg atgatgcctt tgtcattctc gatgaggcgc aaaatacgac catcatgcag
      661 atgaagat
//
LOCUS       DBMVGT010000229          667 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.229, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000229 DBMVGT010000000
VERSION     DBMVGT010000229.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 667)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 667)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.229"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            57..>667
                     /locus_tag="AC0DU4_002286"
     CDS             57..>667
                     /locus_tag="AC0DU4_002286"
                     /inference="COORDINATES: protein motif:HMM:NF012235.6"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4238172.1"
                     /translation="MTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMSRQP
                     QARATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQDVSFAYENKPI
                     LQDFNLLVQAKDRIGIVGDNGVGKSTLLNLIAGSLEPTAGQVVIGETVRIAYFSQQIE
                     GLDESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHG"
BASE COUNT          192 a          139 c          169 g          167 t
ORIGIN      
        1 atcgttattt cttagacgct ttgtcaacac ggattttcga gttggagcga gcaggcttga
       61 cagaatatca gggcaattac caggactatg ttcgccttaa ggcagaacag gacgagcgcg
      121 atgcagctct acttcataaa aaagaacaac tctacaaaca agaactggcc tggatgagca
      181 gacaaccgca ggcgcgtgcg accaagcaac aagctcgtat caatcgtttc catgatctga
      241 aaaaggaagt ttcaggcagt agtgctgaga cagacttgac catgaacttt gaaaccagtc
      301 ggattgggaa gaaagtcatc gagtttcagg atgtttcctt tgcctatgaa aataagccca
      361 ttttgcaaga ttttaatctc ttagttcagg ctaaagaccg tattggaatt gttggggaca
      421 atggtgttgg aaaatcaacc ctacttaacc tgattgcagg aagtcttgag ccgacagcag
      481 gacaagttgt gattggggaa actgttcgca tcgcctattt ctctcaacaa attgagggtt
      541 tggatgaaag caagcgtgtg atcaattacc tgcaggaagt ggcagaggag gtcaagacca
      601 gtggtggttc tacgacttcc atcgctgagt tgctggagca attcctcttc ccacgttcga
      661 cgcatgg
//
LOCUS       DBMVGT010000230          662 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.230, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000230 DBMVGT010000000
VERSION     DBMVGT010000230.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 662)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 662)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..662
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.230"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..380
                     /locus_tag="AC0DU4_002287"
     CDS             <1..380
                     /locus_tag="AC0DU4_002287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000560280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HIN4238173.1"
                     /translation="ADNTIALNIRYPKGTSPEQIKSILENLPVVSVSLSEHGHTPHYV
                     PMEDPLVQTLLNVYEKQTGLKGHEQVIGGGTFGRLLERGVAYGAMFPDSIDTMHQANE
                     FIALDDLFRAAAIYAEAIYELIK"
     gene            434..>662
                     /locus_tag="AC0DU4_002288"
     CDS             434..>662
                     /locus_tag="AC0DU4_002288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HIN4238174.1"
                     /translation="MSQIERIKQAIMADSQNASYTERGIEPLFAAPKTARINIIGQAP
                     GLKTQEAGLYWKDKSGDRLRDWLGVDEDTFYN"
BASE COUNT          196 a          146 c          148 g          172 t
ORIGIN      
        1 gtgctgataa taccattgcc ctcaacatcc gctatccaaa aggaacaagt ccagaacaaa
       61 tcaagtcaat ccttgaaaac ttgccagttg tttctgttag cctgtctgaa cacggtcaca
      121 cgcctcacta tgtgccaatg gaagatccac ttgtgcaaac cttgttgaat gtctatgaaa
      181 aacaaacagg ccttaaaggt catgaacaag tcatcggtgg tggaaccttt ggtcgcttgt
      241 tagagcgcgg agttgcctat ggtgctatgt tcccagactc aattgatacc atgcaccaag
      301 ccaatgaatt tattgccttg gatgatctct tccgagcagc agcaatttat gccgaagcta
      361 tttacgaatt gatcaaataa aacgatagaa gtctgagatc ttatgcttgg acttcttttt
      421 ggagggaaag tagatgtctc aaatcgaaag aatcaaacag gctatcatgg cggattcaca
      481 gaatgccagc tatacagagc gtggcattga gcctctcttt gcagcgccaa aaactgctcg
      541 catcaatatc atcggtcagg ctccgggact taaaactcaa gaagcaggcc tttactggaa
      601 agataaaagt ggtgaccgct tgcgggactg gctaggtgtg gatgaagata ccttttacaa
      661 tt
//
LOCUS       DBMVGT010000231          652 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.231, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000231 DBMVGT010000000
VERSION     DBMVGT010000231.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 652)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 652)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.231"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..563
                     /locus_tag="AC0DU4_002289"
     CDS             <1..563
                     /locus_tag="AC0DU4_002289"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003085743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HIN4238175.1"
                     /translation="GSICTTRVIAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSG
                     DIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKKGSSDRYF
                     QGSINEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGYCGAANLKELHDNAQFI
                     EMSGAGLKESHPHDVQITNEAPNYSM"
BASE COUNT          189 a          114 c          154 g          195 t
ORIGIN      
        1 caggttctat ctgtactact cgtgtgattg ctggtgttgg tgttccgcaa gtaacagcta
       61 tctacgatgc tgcagctgtt gcgcgcgaat atggtaaaac gattattgct gacggtggga
      121 tcaagtattc tggagatatt gtaaaagcac ttgctgcagg tggaaatgct gttatgcttg
      181 gatctatgtt tgctggaact gatgaagctc caggcgaaac tgaaatcttc caaggacgta
      241 aattcaagac ttaccgtggt atgggatcaa ttgctgctat gaagaaaggt tcaagcgacc
      301 gttatttcca aggttctatc aatgaagcaa acaagctcgt tccagaagga attgaaggtc
      361 gtgttgctta taaaggagcg gcagctgata ttgttttcca aatgattggt ggtattcgct
      421 ctggtatggg ttactgtggt gcagctaacc ttaaagaact acacgataat gctcaattta
      481 ttgaaatgtc tggtgctggt ttgaaagaaa gccatcctca tgatgtgcaa attactaatg
      541 aggcaccaaa ttattctatg taaaaaacaa tgaaaagaac tccagtgaaa acaggagttc
      601 ttttacaatg ttgtcaattt ccatttacag cagctttacc atcctgaata gt
//
LOCUS       DBMVGT010000232          644 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.232, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000232 DBMVGT010000000
VERSION     DBMVGT010000232.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 644)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 644)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.232"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>644
                     /locus_tag="AC0DU4_002290"
     CDS             <1..>644
                     /locus_tag="AC0DU4_002290"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003983 - UTP:glucose-1-phosphate
                     uridylyltransferase activity [Evidence IEA];
                     GO_process: GO:0009225 - nucleotide-sugar metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase"
                     /protein_id="HIN4238176.1"
                     /translation="IPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVEEALKSGIED
                     ILVVTGKSKRSIEDHFDSNFELEYNLKEKGKTDLLKLVDETTGMRLHFIRQTHPRGLG
                     DAVLQAKAFVGNEPFVVMLGDDLMDITDEKAVPLTKQLMNDYEKTHASTIAVMPVPHE
                     DVSSYGVIAPQGEGSNGLYSVETFVEKPAPEETPSDLAIIGRYLLTPEIFEILE"
BASE COUNT          198 a          144 c          133 g          169 t
ORIGIN      
        1 atccctgctg ctggactagg aactcgattt ttaccagcaa ccaaggccct tgccaaagaa
       61 atgttgccaa tcgtagacaa accaactatc cagtttatcg tggaagaagc tctcaaatca
      121 ggtattgaag atattctagt tgtcactggt aaatcaaaac gttctattga ggaccacttt
      181 gattcaaact ttgagcttga atacaatctt aaggaaaaag gcaaaacgga tttgttaaaa
      241 ttggtagatg aaacaactgg catgcgcctt catttcatcc gccaaactca tccacgcggt
      301 ctcggagatg ctgttttgca agccaaggct ttcgtcggaa atgaaccttt tgtcgttatg
      361 cttggtgatg acttgatgga tatcacagac gagaaggccg ttcctttgac aaaacaactg
      421 atgaatgatt acgaaaagac acacgcatca accattgctg tcatgcccgt accacacgaa
      481 gacgtttcat catatggagt cattgctcct caaggcgaag gaagcaatgg actctatagc
      541 gttgaaactt tcgttgaaaa accagctccc gaggagactc caagtgattt ggcaatcatc
      601 ggtcgctatc tactcacacc agaaattttt gagattctcg aaaa
//
LOCUS       DBMVGT010000233          640 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.233, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000233 DBMVGT010000000
VERSION     DBMVGT010000233.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 640)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 640)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.233"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..640)
                     /locus_tag="AC0DU4_002291"
                     /pseudo
     CDS             complement(1..640)
                     /locus_tag="AC0DU4_002291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862319.1"
                     /note="frameshifted; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA];
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
BASE COUNT          179 a          181 c          126 g          154 t
ORIGIN      
        1 ggaagtctca ggtctttagc cagctgcaat tcagctgcca catcgtagtc tacccgtcgg
       61 aagtccatat ctaccaggcc cttgtcatca aactccaaaa tcatatactg ggcccgcaag
      121 tccttccgta gctgagcgtc caaaaagaaa ggttggccaa tcgaacccgg attgacaatc
      181 aattgcccac cagtcccgta acgaagcaac tgctggtgaa tatgtccata aacagcaata
      241 tcacagggag gatgagtcac caagcggtca aactcctctt gtttgccagt atgaatcaac
      301 tctcgccccc agttcttatc aggcagatga tggctaattc ccaccgtcaa atccccaaac
      361 tgacgatgaa tttgaagagg ttgattgtgg agcacttcaa tttcttctag ggaaatttcc
      421 tctaaaacat actggcactg gcgcaagaga tagcgttgac tggggcgagt actatccaat
      481 tccttacgga caccatgcca aagactgtct tcccagtttc ccaaaactct agccgtaatc
      541 ggtagttgat ccaacaagtc caaaatcctt ctacgccctg tccctggcat gagaatatct
      601 cccaaaacca gtattcatcc actcctatct gccgagcatc
//
LOCUS       DBMVGT010000234          638 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.234, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000234 DBMVGT010000000
VERSION     DBMVGT010000234.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 638)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 638)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.234"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..152
                     /locus_tag="AC0DU4_002292"
     CDS             <1..152
                     /locus_tag="AC0DU4_002292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HIN4238177.1"
                     /translation="YSNAKLEATNNLIKLIKYNAFGFRNFENFKKERTKFVLSRSSLS
                     STHYS"
     gene            complement(187..396)
                     /locus_tag="AC0DU4_002293"
                     /pseudo
     CDS             complement(187..396)
                     /locus_tag="AC0DU4_002293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(562..635)
                     /locus_tag="AC0DU4_002294"
     tRNA            complement(562..635)
                     /locus_tag="AC0DU4_002294"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(599..601),aa:Asn,seq:gtt)
BASE COUNT          216 a          131 c           98 g          193 t
ORIGIN      
        1 cttattccaa cgccaaactg gaagccacca ataatctcat caaacttatc aagtacaatg
       61 cctttggttt taggaacttt gaaaacttca aaaaagaaag gacgaaattt gtcctttcta
      121 gatcttcgct ttcttcaacc cactacagtt gacaaagaac cgaaaaatgt ctcgcctcta
      181 atatagtcaa ttgaaacaag aacaagacaa aagagcctca taaaaggtat tgcaacttgc
      241 taataccttt ttggggttct ttttgatatg aacccatgtt ttctcaatag gattgtactc
      301 aggtgagtag ggaggaagag gtaaaagttt atgcccaaac tcttcacaca agagttctag
      361 cttacccatt ctatggaatc ttgcattgtc cataatatag tagattgaaa ctagaatagt
      421 acacctctac ttctaaaaca ttgttagaat tcgattttac tgtcctgatc gatttgtcct
      481 attcttattt cattttacta taacacgaaa tagattatta ttacataaca aaaaagaggt
      541 ctaaacctct taactaaatt actccgccag taggactcga acctacgaca tcatgattaa
      601 cagtcatgcg ctactaccaa ctgagctatg gcggatta
//
LOCUS       DBMVGT010000235          631 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.235, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000235 DBMVGT010000000
VERSION     DBMVGT010000235.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 631)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 631)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..631
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.235"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>631
                     /locus_tag="AC0DU4_002295"
     CDS             <1..>631
                     /locus_tag="AC0DU4_002295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose epimerase family protein"
                     /protein_id="HIN4238178.1"
                     /translation="DKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAGRIAGATFEL
                     NGKTYDLEVNNASNCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIW
                     ISYHLEETGAYEISYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSI
                     TPDGVPAKTPEANRDVVKHIYNGTLLKDIFAEEDEQIQLASGLDHPFALP"
BASE COUNT          177 a          134 c          151 g          169 t
ORIGIN      
        1 gacaaggctg gaaattttgc caatgttatc ttgggatttg atgactttga tagttatgta
       61 ggcaatagtc ccaagcatgg agcaagtgta ggtcctgtag cgggtcgtat tgcaggtgcg
      121 acctttgagc tcaatggtaa gacctatgac cttgaggtta ataatgctag caactgtaat
      181 cacagtggtt caactggttg ggattccagc ttgtttgaag ttgaagaagt aagcgatcat
      241 ggcttgactc tctacacaga acgtacagat gggacaggag ggttccctgg aaatctcaag
      301 atttggatca gttatcactt ggaagaaact ggtgcctatg aaattagcta caaggtaacg
      361 accgatcagg atacgctggt caatccaacc aaccacagct atttcaactt gtctggtgat
      421 ttcacgcaga cgattgaccg tcatgtcttc caactaaaca cagagggcat ttactcaatc
      481 actcctgacg gtgttcctgc caaaactcca gaagccaacc gtgatgtggt caaacacatc
      541 tacaatggta ccttgttgaa ggatatcttt gcagaagaag atgagcaaat ccagctggca
      601 tcaggtttgg atcacccatt tgcccttcct g
//
LOCUS       DBMVGT010000236          629 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.236, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000236 DBMVGT010000000
VERSION     DBMVGT010000236.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 629)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 629)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.236"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>629
                     /locus_tag="AC0DU4_002296"
     CDS             <1..>629
                     /locus_tag="AC0DU4_002296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014639013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004812 - aminoacyl-tRNA ligase activity
                     [Evidence IEA];
                     GO_process: GO:0006418 - tRNA aminoacylation for protein
                     translation [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="class I tRNA ligase family protein"
                     /protein_id="HIN4238179.1"
                     /translation="ETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGP
                     LDASIAWSEEGLEGSRKFLDRVYRLITSKEILAENNGALDKAYNETVKAVTEQIESLK
                     FNTAIAQLMVFVNAANKEDKLYVDYAKGFIQLIAPFAPHLAEELWQTVAETGESISYV
                     AWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDISREELQEIALADEK"
BASE COUNT          202 a          121 c          144 g          162 t
ORIGIN      
        1 tagaaacagg ggaagagttg gagcaagcgc cagccaagat gtctaaatcg ctcaagaacg
       61 ttgttaaccc agatgatgtg gtggaacaat acggtgccga tacccttcgt gtttatgaaa
      121 tgtttatggg accactcgat gcttcgattg cttggtcaga agaaggtttg gaaggaagcc
      181 gtaagttcct tgaccgagtt taccgtttga ttacaagtaa agaaatcctt gcggaaaaca
      241 atggtgctct tgacaaggct tacaacgaaa cagtcaaagc tgttactgag caaattgagt
      301 ctctcaaatt caacacagct attgcccaac ttatggtctt tgtcaatgct gctaacaagg
      361 aagataagct ttatgttgac tatgccaaag gctttattca attgattgca ccatttgcac
      421 ctcacttggc agaagaactc tggcaaacag tcgcagaaac aggtgagtca atctcttatg
      481 tagcttggcc aacttgggac gaaagtaaac tggttgaaga cgaaatcgaa atcgttgtcc
      541 aaatcaaagg taaagtccgt gccaaactca tggttgctaa agatatatca cgtgaagaat
      601 tacaagaaat cgctttagct gatgaaaaa
//
LOCUS       DBMVGT010000237          626 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.237, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000237 DBMVGT010000000
VERSION     DBMVGT010000237.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 626)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 626)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..626
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.237"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>626
                     /locus_tag="AC0DU4_002297"
     CDS             <1..>626
                     /locus_tag="AC0DU4_002297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0015424 - ABC-type amino acid transporter
                     activity [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HIN4238180.1"
                     /translation="LTVHKGEVISIIGSSGSGKSTFLRSINLLETPTDGQILYHGQNV
                     LEKGYDLTQYREKLGMVFQSFNLFENLNVLENTIVAQTTVLKRERTEAEKIAKENLEK
                     VGMGERYWQAKPKQLSGGQKQRVAIARALSMNPDAILFDEPTSALDPEMVGEVLKIMQ
                     DLAQEGLTMIVVTHEMEFARDVSHRVIFMDKGVIAEEGKPEDLFTNPK"
BASE COUNT          196 a          158 c          131 g          141 t
ORIGIN      
        1 ctcactgtcc acaagggaga ggtcatctct atcatcggaa gctctggaag cggaaaatcg
       61 accttcctac gctccattaa cctacttgaa acaccaactg atggacaaat cctttatcat
      121 ggacaaaacg tcctcgaaaa aggctatgac ctcacgcaat accgtgaaaa gttggggatg
      181 gttttccaat cctttaacct ctttgaaaat ctcaatgttc ttgaaaacac aatcgtcgct
      241 cagacaactg tcctaaaacg cgaacgcaca gaagctgaaa agattgccaa agaaaacctg
      301 gaaaaggtcg gcatgggaga acgctactgg caagccaaac caaaacaact ctcaggtggt
      361 caaaaacaac gtgtggccat cgctcgtgcc ctctccatga atccggacgc tattctcttt
      421 gatgaaccaa catcagctct cgatccagaa atggttggag aagtcctcaa aatcatgcag
      481 gacctggctc aggaaggctt gaccatgatt gtcgtaaccc atgaaatgga atttgcccgt
      541 gatgtctctc accgtgttat ctttatggat aagggcgtga tcgctgaaga aggtaaacca
      601 gaagacctct tcaccaatcc taaaga
//
LOCUS       DBMVGT010000238          624 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.238, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000238 DBMVGT010000000
VERSION     DBMVGT010000238.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 624)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 624)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.238"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>624
                     /locus_tag="AC0DU4_002298"
     CDS             <1..>624
                     /locus_tag="AC0DU4_002298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001032503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0033926 -
                     endo-alpha-N-acetylgalactosaminidase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="endo-alpha-N-acetylgalactosaminidase family
                     protein"
                     /protein_id="HIN4238181.1"
                     /translation="KEINKQGWRFAIEWGHGGEYDSTFHHWAADLTYGGYTNKGINSA
                     ITRFIRNHQKDAWVGDYRSYGGAANYPLLGGYSMKDFEGWQGRSDYNGYVTNLFAHDV
                     MTKYFQHFTVSKWENGTPVTMTDNGSTYKWTPEMRVELVDADNNKVVVTRKSNDVNSP
                     QYRERTVTLNGRVIQDGSAYLTPWNWDANGKKLSTEKEKMYYFNTQAG"
BASE COUNT          192 a          136 c          151 g          145 t
ORIGIN      
        1 aaagaaatta acaaacaagg ctggcgcttt gcgatcgagt ggggccatgg tggtgagtac
       61 gactctacct tccatcactg ggcagctgac ttgacctacg gtggctacac caataaaggt
      121 atcaacagtg ccatcacccg ctttatccgt aaccaccaaa aagatgcttg ggttggggac
      181 tacagaagtt atggtggtgc agccaactat ccactgctag gtggctacag catgaaagac
      241 tttgaaggct ggcaaggacg gagcgactac aatggctacg tgactaacct ctttgcccat
      301 gatgtcatga ccaagtattt ccaacacttc actgtaagta aatgggaaaa tggtacaccg
      361 gtgactatga ccgataacgg tagcacctat aaatggactc cagaaatgcg agtggaattg
      421 gtagatgctg acaataataa agtagttgta actcgtaagt caaatgatgt caatagccca
      481 caatatcgcg aacgtacagt aactctcaac ggacgtgtca tccaagatgg ttcagcttac
      541 ttgactcctt ggaactggga tgcaaatggt aagaaacttt ctactgagaa ggaaaagatg
      601 tactacttca atacgcaggc cggt
//
LOCUS       DBMVGT010000239          624 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.239, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000239 DBMVGT010000000
VERSION     DBMVGT010000239.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 624)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 624)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.239"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>624
                     /locus_tag="AC0DU4_002299"
     CDS             <1..>624
                     /locus_tag="AC0DU4_002299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="cell surface protein"
                     /protein_id="HIN4238182.1"
                     /translation="EKEISNLEILLGGADSEDDTAALQNKLATKKAELEKTQKELDAA
                     LNELGPDGDEEETPAPAPQPEQPAPAPKPEQPAPAPKPEQPAPAPKPEQPAKPEKPAE
                     EPTQPEKPATPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNANGSMATGWVKD
                     GDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYRVNA"
BASE COUNT          226 a          140 c          134 g          124 t
ORIGIN      
        1 agaaaaagaa attagtaacc ttgaaatatt acttggaggg gctgattctg aagatgatac
       61 tgctgctctt caaaataaat tagctactaa aaaagctgaa ttggaaaaaa ctcaaaaaga
      121 attagatgca gctcttaatg agttaggccc tgatggagat gaagaagaaa ctccagcgcc
      181 ggctcctcaa ccagagcaac cagctcctgc accaaaacca gagcaaccag ctcctgcacc
      241 aaaaccagag caaccagctc ctgcaccaaa accagagcaa ccagctaagc cggagaaacc
      301 agctgaagag cctactcaac cagaaaaacc agccactcca aaaacaggct ggaaacaaga
      361 aaacggtatg tggtatttct acaatactga tggttcaatg gcaacaggtt ggctccaaaa
      421 caacggttca tggtactacc taaacgctaa cggttcaatg gcaacaggtt gggtgaaaga
      481 tggagatacc tggtactatc ttgaagcatc aggtgctatg aaagcaagcc aatggttcaa
      541 agtatcagat aaatggtact atgtcaatgg cttaggtgcc cttgcagtca acacaactgt
      601 agatggctat agagtcaatg ccaa
//
LOCUS       DBMVGT010000240          618 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.240, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000240 DBMVGT010000000
VERSION     DBMVGT010000240.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 618)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 618)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..618
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.240"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..288
                     /locus_tag="AC0DU4_002300"
     CDS             <1..288
                     /locus_tag="AC0DU4_002300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DapH/DapD/GlmU-related protein"
                     /protein_id="HIN4238183.1"
                     /translation="VGKNSHVGAGAVLAGVIEPASAEPVRVGDNVLIGANAVVIEGVQ
                     IGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQTQQKTALEDALRTL"
     gene            356..>618
                     /locus_tag="AC0DU4_002301"
     CDS             356..>618
                     /locus_tag="AC0DU4_002301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyldiaminopimelate deacetylase"
                     /protein_id="HIN4238184.1"
                     /translation="MLDLIQTRRDLHQIPEIGLEEFKTQAYLLDVIEKLTTGKDFVQI
                     RTWRTGILVYLQGSQPERTIGWRTDIDGLPIVEQTGLPFASQH"
BASE COUNT          168 a          121 c          166 g          163 t
ORIGIN      
        1 gttggaaaaa atagccacgt tggtgcaggt gcagttttgg caggtgtgat tgagccagct
       61 agtgctgaac cagtccgtgt cggagacaat gttctcatcg gggctaatgc agtggttatc
      121 gaaggagtcc aaatcggtag tggttcagtt gtcgcagcag gagctattgt tacccaagat
      181 gtcccagaaa acgtggtagt agcaggtgtt ccagctcgta ttatcaaaga aattgatgcc
      241 caaactcaac aaaaaacagc gctagaggat gcgcttcgta ccttgtaatt gtaaaagtaa
      301 aaaagaggcg gaaccctttt tccagcctct ttctgctata tcggaggaca gatagatgtt
      361 agatttgatt cagactagac gagatttaca ccagattcca gagattggct tggaggagtt
      421 caagactcag gcttatttgc tggatgtgat tgagaaattg actacgggca aggattttgt
      481 tcaaattcgt acttggcgga cagggatttt ggtctacctg cagggaagtc agccggagcg
      541 aaccattggt tggcggacag atattgatgg cctgcctatc gtcgaacaaa caggtctacc
      601 ttttgcttct caacacca
//
LOCUS       DBMVGT010000241          610 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.241, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000241 DBMVGT010000000
VERSION     DBMVGT010000241.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 610)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 610)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.241"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..132
                     /locus_tag="AC0DU4_002302"
     CDS             <1..132
                     /locus_tag="AC0DU4_002302"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HIN4238185.1"
                     /translation="VREFRGLAPHYLRGTSGAAKLRGAISQASTLAEIEALLQLEKV"
     gene            complement(352..>610)
                     /locus_tag="AC0DU4_002303"
     CDS             complement(352..>610)
                     /locus_tag="AC0DU4_002303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HIN4238186.1"
                     /translation="PKPEVKPDNSKPQADDKKPSTPNNLSKDKQSSNQASTNENKKQG
                     PATNKPKKSLPSTGSISNLALEIAGLLTLAGATILAKKRMK"
BASE COUNT          168 a          120 c          107 g          215 t
ORIGIN      
        1 gttcgtgaat tccgcggcct cgctcctcac tatctccgtg gaacatctgg cgctgccaaa
       61 ctccgtggag ccatttcgca agctagcacc ctagcagaga ttgaagccct cttgcaatta
      121 gaaaaagtat aatgcaaaaa agagcctagg acaaaagtat aatattaaat ataaaaagca
      181 aacaaaatca gttatctgac actcagaatt ctgtcttgtt cgcttttttg tctaatctat
      241 cgattttaaa aatttataat aaagaattcc taaaatcaaa atctttttat cccagactct
      301 tttctttcta agccgaatac tttttacaaa catttttgaa tgaatcaatc actatttcat
      361 tcttttctta gcaagaatgg ttgcccccgc caaggtaaga agacctgcaa tttcaagtgc
      421 tagatttgaa atagatccag ttgatggcaa tgacttcttc ggtttatttg ttgctggacc
      481 ttgcttcttg ttttcgtttg ttgaagcttg gttagaagat tgcttgtcct tgcttaaatt
      541 atttggagtt gatggcttct tatcatctgc ttgtggcttg ctattatctg gtttaacctc
      601 tggttttggt
//
LOCUS       DBMVGT010000242          609 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.242, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000242 DBMVGT010000000
VERSION     DBMVGT010000242.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 609)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 609)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.242"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..89
                     /locus_tag="AC0DU4_002304"
     CDS             <1..89
                     /locus_tag="AC0DU4_002304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="HIN4238187.1"
                     /translation="EVSLFLASGKASAMQGQILTIDGGWSLK"
     gene            100..579
                     /locus_tag="AC0DU4_002305"
     CDS             100..579
                     /locus_tag="AC0DU4_002305"
                     /EC_number="3.6.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HIN4238188.1"
                     /translation="MEIKNHFGVYCVCFENGKLLCIEKTRGPYQHRYDLPGGSQQLGE
                     GLTETLTREVMEETGFTVRSYSNPRIYDVFVREELKNFMVHHVIALYDVEMNESAPQV
                     TISEAVSDGANDSLGYIWMDIQEITEENASPLVLKVKSELLGLPELDKTSYMNWKVK"
BASE COUNT          190 a           89 c          158 g          172 t
ORIGIN      
        1 cagaagtcag tctctttttg gccagtggaa aggcatctgc catgcaggga caaattctga
       61 caatagatgg tggctggtct ttgaagtagg aggagttgga tggaaatcaa aaatcacttt
      121 ggggtctact gtgtttgctt tgaaaatgga aagttacttt gcattgaaaa aacgagaggc
      181 ccttatcaac atcggtatga tctacctgga ggcagtcagc aacttggtga aggactgacg
      241 gaaacgctga ctagagaagt tatggaagag acgggattta ctgttagaag ctactctaat
      301 cctcgaatct acgatgtttt cgtcagggaa gagttaaaaa attttatggt tcaccatgtc
      361 atagccttgt atgatgttga aatgaatgag agtgcacctc aagttacgat ttcggaagct
      421 gtgtctgatg gtgcgaatga ttcacttgga tatatttgga tggatattca agagattaca
      481 gaagaaaatg catcgccatt agtcttgaag gttaagtctg aattattagg attgccagaa
      541 ctggacaaga cttcttacat gaattggaag gtgaagtaga gggataatgg aactatttaa
      601 aacatggaa
//
LOCUS       DBMVGT010000243          607 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.243, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000243 DBMVGT010000000
VERSION     DBMVGT010000243.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 607)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.243"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..324
                     /locus_tag="AC0DU4_002306"
     CDS             <1..324
                     /locus_tag="AC0DU4_002306"
                     /EC_number="5.4.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006703946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004619 - phosphoglycerate mutase activity
                     [Evidence IEA];
                     GO_function: GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA];
                     GO_process: GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="2,3-bisphosphoglycerate-dependent
                     phosphoglycerate mutase"
                     /protein_id="HIN4238189.1"
                     /translation="MDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERALPFWEDKI
                     APALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDEKLNVVSE
                     YYLGK"
     gene            377..>607
                     /locus_tag="AC0DU4_002307"
     CDS             377..>607
                     /locus_tag="AC0DU4_002307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000620712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase N-terminal domain-containing
                     protein"
                     /protein_id="HIN4238190.1"
                     /translation="MIRNKKQDYVLAYKQPASTTYMGWEEEALPIGNGSLGAKVFGLI
                     GAERIQFNEKSLWSGGPLPDSSDYQGGNLQDQY"
BASE COUNT          191 a          115 c          133 g          168 t
ORIGIN      
        1 atggaccgtg atgatgagca ctcagctcac acagaccgtc gttacgcttc acttgacgac
       61 tcagttatcc cagatgctga aaacttgaaa gtgactttgg aacgtgctct tccattctgg
      121 gaagataaaa tcgctccagc tcttaaagat ggtaaaaacg tattcgtagg agctcacggt
      181 aactcaatcc gtgcccttgt aaaacacatc aaaggtttgt cagatgacga gatcatggac
      241 gtggaaatcc ctaacttccc accattggta ttcgaattcg acgaaaaatt gaacgtcgtt
      301 tctgaatact accttggaaa ataaaaaatt gtaagtctag aattgatttc taggcttttt
      361 atgttagtat ggaagtatga taaggaataa aaaacaagat tatgtactgg cctacaagca
      421 accagcttca accacttaca tgggttggga agaagaagct ttaccgatag gcaatggttc
      481 tttaggagca aaagtatttg gccttatagg ggctgaacgg attcaattta atgaaaaaag
      541 tctctggtct ggaggtccac ttcctgatag ttcagattat cagggtggaa atcttcagga
      601 tcagtat
//
LOCUS       DBMVGT010000244          603 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.244, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000244 DBMVGT010000000
VERSION     DBMVGT010000244.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 603)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 603)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.244"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>603)
                     /locus_tag="AC0DU4_002308"
     CDS             complement(<1..>603)
                     /locus_tag="AC0DU4_002308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004560 - alpha-L-fucosidase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HIN4238191.1"
                     /translation="KEILSNPAYGNGGKFAEVWMDGARGEGAQKVNYEFEKWFETIRD
                     LQGNCLIFSTEGTSIRWIGNERGYAGDPLWQKVNPDKLGTEAELDYLQHGDPSGTIFS
                     IGEADVSIRPGWFYHEDQDPKSLEELVEIYFHSVGRGTPLLLNIPPNQAGLFDAKDIE
                     RLYEFATYRNELYKEDLALGAEVSGPALSADFACRHLTDG"
BASE COUNT          159 a          162 c          121 g          161 t
ORIGIN      
        1 ggccgtctgt caaatggcga caagcaaagt ctgcggaaag agctggacca gatacctcag
       61 ctcccagagc caaatcttct ttatagagct cattgcgata ggtcgcaaat tcataaagtc
      121 gttcaatatc ctttgcatca aagagcccag cttgattcgg cggaatatta agcaagagtg
      181 gagttcctcg ccctactgag tgaaagtaga tttcgaccaa ctcctcgaga gacttaggat
      241 cctgatcctc atggtagaac cagcctggac ggatggaaac atctgcctct ccgattgaaa
      301 aaatcgtgcc cgagggatcc ccgtgctgaa gatagtccag ctctgcttct gttcctagtt
      361 tatcaggatt caccttttgc cacagtggat cacctgcata ccctcgttca ttgccaatcc
      421 atcggatact ggtgccttct gttgaaaaaa tcaagcaatt gccctgcagg tcacgaatgg
      481 tttcaaacca tttttcaaat tcataattaa ccttttgcgc gccctctcct ctggcaccat
      541 ccatccaaac ctcagcaaat ttccctccat ttccataggc aggatttgat aagatttcct
      601 tca
//
LOCUS       DBMVGT010000245          601 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.245, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000245 DBMVGT010000000
VERSION     DBMVGT010000245.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 601)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 601)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..601
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.245"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..601)
                     /locus_tag="AC0DU4_002309"
                     /pseudo
     CDS             complement(1..601)
                     /locus_tag="AC0DU4_002309"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237556.1"
                     /note="frameshifted; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
BASE COUNT          224 a          113 c          130 g          134 t
ORIGIN      
        1 ccaattacaa gggccatcag gattgcacta taaataaaca ataaaactat ggcgactatg
       61 ccatttgaac gattcaccag gtccgtaatg ctactccaat tggttgacag atttttcaca
      121 tccttaaaat aatggtgaca agaaaggatg acactggcaa ggatccatgc cacaataagg
      181 taaatcatcg aaaggatggg caagcctaga tatagagaaa gaccaagtaa agtcagaact
      241 ggtaaaaagg actgaacagc aaagataatc caaaatttca ctttcacata acgagcaaag
      301 tcaaagggta aactcttcag aaaatcaaca ttttccctct ccaaggacaa ggcaattgaa
      361 ggcaggctgg tgatattgtt attgacaact gctataaaga gagctataaa aaaaagggta
      421 accagtatgg aggatgaatg tctggaacta tctgagaatc tcggattttg gaaatcagac
      481 cgatcatcat gagataagga aggaaagcac ttgtaaaaag cactgtaacc acgccagtcc
      541 cctgtcccaa gagggtgagg tggtagcgta aaaccatgcg gaaaaatccc tttttagtgg
      601 t
//
LOCUS       DBMVGT010000246          599 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.246, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000246 DBMVGT010000000
VERSION     DBMVGT010000246.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 599)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 599)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.246"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>599
                     /gene="comB"
                     /locus_tag="AC0DU4_002310"
     CDS             <1..>599
                     /gene="comB"
                     /locus_tag="AC0DU4_002310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="competence pheromone export protein ComB"
                     /protein_id="HIN4238192.1"
                     /translation="EIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKS
                     QGEENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQH
                     LAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEGA
                     LLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTT"
BASE COUNT          178 a          136 c          142 g          143 t
ORIGIN      
        1 ccgaaatcgg caacctcatc agtcaaacag aggctaaaat tcgcgattac cagacagcta
       61 agtcagctat tgaaacaggt gcttccttgg ccggtcagaa tctagcctac tctctttacc
      121 agtcctacaa gtctcagggc gaggaaaatc cccaaactaa ggttcaggca gttgcacagg
      181 ttgaagcaca gatttctcag ttagaatcta gtcttgctac ttaccgtgtc cagtatgcag
      241 gttcaggtac ccagcaagcc tatgcgtcag ggttaagcag tcaattggaa tcccttaaat
      301 cccaacactt ggcaaaggtt ggtcaggaat tgacccttct agcccagaaa atcttggagg
      361 cagagtcagg taagaaggta cagggaaatc ttttagacaa ggggaaaatt acggcgagtg
      421 aggatggggt gcttcatctt aatcctgaga ccagtgattc tagcatggtt gcagaaggtg
      481 ccctactagc ccaactttat ccatctttgg aaagagaagg gaaagccaaa ctcacagcct
      541 atctaagttc aaaagatgta gcaagaatca aggtcggtga ttctgttcgc tatactacg
//
LOCUS       DBMVGT010000247          597 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.247, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000247 DBMVGT010000000
VERSION     DBMVGT010000247.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 597)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 597)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.247"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>597)
                     /locus_tag="AC0DU4_002311"
     CDS             complement(<1..>597)
                     /locus_tag="AC0DU4_002311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HIN4238193.1"
                     /translation="GVSKVQELQMTTQNGDNTHVIAIDGNFDDAQTNVKHMFNDVALR
                     ERLAANKLQFSSANSMNIGRLVPQIVYYVYAYAQLVKTGEIVAGDKINFTVPTGNFGN
                     ILAAFYAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPSMDILVSSNL
                     ERLIFHLLGNDAVKTAELMNALNTQGQYELTDFDVEIL"
BASE COUNT          180 a          134 c          110 g          173 t
ORIGIN      
        1 tccagaatct ctacatcaaa atcagtcagt tcatattgtc cttgtgtatt caaggcattc
       61 atgagttcag ccgtcttaac cgcatcattc cccaaaagat ggaaaatcaa acgctccaag
      121 tttgaagata ccaagatatc catagatggg ctggttgtta ccttaaactc acgtttcttg
      181 tcgtaaacac gtgtcttgaa gaagtctgtc aaaacattgt tatcatttga agcacagatc
      241 aatttaccaa ctgggagacc gatttgtttg gcataaaagg cagccaagat atttccaaag
      301 tttcctgttg gtactgtgaa gttaatctta tcaccagcca cgatctcacc agtcttgacc
      361 aactgagcat aggcataaac ataataaaca atctgtggca ccaaacgacc gatattcata
      421 gagttagcag atgaaaattg caacttgttg gccgctaatc tttcacgaag agccacgtcg
      481 ttaaacatgt gcttcacgtt ggtttgcgca tcgtcaaagt taccatctat agcgataaca
      541 tgagtattgt caccattctg agtggtcatt tgcaactctt gtaccttgct gacacca
//
LOCUS       DBMVGT010000248          593 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.248, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000248 DBMVGT010000000
VERSION     DBMVGT010000248.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 593)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 593)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.248"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>593)
                     /locus_tag="AC0DU4_002312"
     CDS             complement(<1..>593)
                     /locus_tag="AC0DU4_002312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA];
                     GO_process: GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HIN4238194.1"
                     /translation="ALDLLARHFVGASVAESIGKFFAPLFSAADGYLGITIIFGAFAF
                     FWFVGIHGPSIVEPAIAAITYANAEVNLNLLQQGMHADKILTSGTQMFIVTMGGTGAT
                     LVVPFMFMWLTKSKRNRAIGRASVVPTFFGVNEPILFGAPLVLNPIFFIPFIFAPIAN
                     VWIFKFFIETLGMNSFTANLPWTTPAPLGLVLGTNFQV"
BASE COUNT          206 a          109 c          138 g          140 t
ORIGIN      
        1 acttggaagt tagtaccaag aactagacct agtggagctg gggttgtcca tggtagatta
       61 gcagtgaatg agttcattcc aagagtttca ataaagaatt taaagatcca tacgtttgca
      121 attggagcaa agataaatgg aatgaagaag attggattca aaacaagagg tgcaccaaac
      181 aagattggct catttacacc gaagaaggta ggaactactg aagcacgtcc gattgcacgg
      241 ttacgttttg attttgttaa ccacatgaac atgaatggaa caaccagtgt cgcaccagta
      301 ccacccatgg taacgataaa catttgtgta ccagaagtaa gaatcttgtc agcgtgcata
      361 ccttgttgga gaaggttcaa gttgacttca gcatttgcat aggtaattgc tgcgatagca
      421 ggttcaacaa tagatggacc atgaataccc acaaaccaga agaaggcaaa ggcaccaaag
      481 ataatggtaa taccaaggta tccgtctgct gctgagaaga gtggtgcaaa gaatttaccg
      541 attgattcag ctacgcttgc accaacaaaa tgacgagcta gtaaatcaag agc
//
LOCUS       DBMVGT010000249          574 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.250, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000249 DBMVGT010000000
VERSION     DBMVGT010000249.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 574)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 574)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.250"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>574
                     /locus_tag="AC0DU4_002313"
     CDS             <1..>574
                     /locus_tag="AC0DU4_002313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA];
                     GO_process: GO:0006812 - monoatomic cation transport
                     [Evidence IEA];
                     GO_process: GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="potassium transporter TrkG"
                     /protein_id="HIN4238195.1"
                     /translation="IDAFFEISSGFTTTGASILNDISVLSRSLLFWRSFTHLIGGMGV
                     LVFALAIMDNAKNSHLEVMKAEVPGPVFGKVVSKLKNTAQILYLLYIALFSLFVIIYY
                     LAGMPLYDSFVIAMGTAGTGGFTVYNDGIAHYGSSLITYLVSIGVLVFGVNFNLYYYL
                     MLRRVKAFFGDEELRAYLVIVLVSTGLISL"
BASE COUNT          126 a          121 c          126 g          201 t
ORIGIN      
        1 ttattgatgc cttttttgaa attagttctg ggtttacaac tactggagca agtattttga
       61 acgacatttc ggttctcagc cgttccctcc tcttctggcg aagttttacc cacttgattg
      121 gagggatggg agtgcttgtt tttgcacttg ctattatgga caatgccaaa aatagtcacc
      181 tagaagtaat gaaggctgag gttcctggtc ctgtctttgg taaggttgta tccaaattaa
      241 aaaacactgc ccagatcctc tatctccttt acatagccct cttttccctc tttgtcatca
      301 tctattatct agccggtatg cctctctacg atagttttgt cattgctatg gggacagcgg
      361 gaactggagg atttaccgtc tataacgatg gaattgccca ctatggtagc tcactgatta
      421 cctatctggt tagtatagga gttttggttt ttggggtaaa tttcaatctc tactactacc
      481 ttatgctccg tcgggttaag gccttctttg gagatgaaga gcttcgggct tacttggtca
      541 tcgtgctggt ttctacaggc ttgattagcc tcaa
//
LOCUS       DBMVGT010000250          569 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.251, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000250 DBMVGT010000000
VERSION     DBMVGT010000250.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 569)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 569)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.251"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>569
                     /locus_tag="AC0DU4_002314"
     CDS             <1..>569
                     /locus_tag="AC0DU4_002314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="HIN4238196.1"
                     /translation="AKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQVWLAKRMGKK
                     KIIAETGAGQHGVATATAAALFNMECTIYMGEEDVKRQALNVFRMELLGAKVEAVTDG
                     SRVLKDAVNAALRSWVANIDDTHYILGSALGPHPFPEIVRDFQSVIGREAKQQYRDMT
                     GQNLPDALVACVGGGSNAIGLFHPFVEDES"
BASE COUNT          150 a          134 c          146 g          139 t
ORIGIN      
        1 gcaaaaaact tgacccagca tatcggcgga gccaagattt atctcaaacg ggaagacctt
       61 aaccatacag gagcccacaa gattaacaat gccttaggac aagtttggct tgccaaacgc
      121 atgggtaaaa agaaaattat cgcagaaacg ggtgctggtc agcacggtgt ggcaactgca
      181 actgctgcgg ccctctttaa catggaatgt accatctaca tgggtgagga agatgtcaaa
      241 cgccaagccc tcaatgtgtt ccgtatggag cttttgggag ctaaggttga ggcagtgaca
      301 gatggttcgc gcgtgctcaa ggatgcggtc aatgcagccc ttcgttcatg ggtggctaat
      361 atcgacgata cccactatat ccttggttct gccttggggc ctcatccatt tccagaaatc
      421 gttcgtgact tccaaagtgt catcggtcgc gaagctaaac aacagtatcg cgatatgaca
      481 ggtcaaaatc tgcccgatgc cctagtagcc tgtgttggtg gtggatctaa tgctattggg
      541 ctcttccatc cctttgtaga agatgagtc
//
LOCUS       DBMVGT010000251          567 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.252, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000251 DBMVGT010000000
VERSION     DBMVGT010000251.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 567)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.252"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>567
                     /locus_tag="AC0DU4_002315"
     CDS             <1..>567
                     /locus_tag="AC0DU4_002315"
                     /EC_number="2.7.13.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA];
                     GO_function: GO:0004673 - protein histidine kinase
                     activity [Evidence IEA];
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_process: GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HIN4238197.1"
                     /translation="WRGIEELSLRKMQANLKRLLAGQEVVQVADPDLDASFKSLSGKL
                     NLLTEALQKAENHSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQQALKL
                     DREKMQIQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELEDKSDLR
                     VSLKQNMTKLPKKIEEHIFRILQELISNT"
BASE COUNT          174 a           99 c          147 g          147 t
ORIGIN      
        1 ttggcgaggg atcgaagagc tttctctaag aaaaatgcag gctaatctca agcgtttatt
       61 ggcagggcaa gaagtggttc aggttgcaga tccagatttg gatgccagtt tcaagtcctt
      121 atcaggtaaa cttaaccttt tgacagaagc tcttcaaaaa gctgaaaatc atagccttgc
      181 tcaggaagag gaaatcatcg agaaagaacg gaagcgaatt gctcgggatt tgcacgatac
      241 agtcagtcag gagttgtttg cggcccacat gattttatcg ggtatcagtc agcaggcttt
      301 gaaattggat agagaaaaga tgcagatcca gttgcagagt gtcacagcta ttttagaaac
      361 tgcccagaag gatttgcggg ttttgctctt gcatttgcga ccagttgaac tggagcagaa
      421 gagcttgata gaagggattc agattctctt aaaagagctt gaggacaaga gtgatcttag
      481 ggttagtctc aagcagaata tgacgaaatt gcctaagaaa atcgaggagc atatcttccg
      541 tatcctgcaa gagttgatta gcaatac
//
LOCUS       DBMVGT010000252          564 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.253, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000252 DBMVGT010000000
VERSION     DBMVGT010000252.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 564)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 564)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.253"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>564
                     /locus_tag="AC0DU4_002316"
     CDS             <1..>564
                     /locus_tag="AC0DU4_002316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="peptidase M42"
                     /protein_id="HIN4238198.1"
                     /translation="TREISNYLVKTLEGFGYQPVRTAKGGVNVTIKGQNDGQHRYVTA
                     HVDTLGAIVRAVKPDGRLKLDRIGGFPWNMIEGENCTVHVASTGQKVSGTILIHQTSC
                     HVYKDAGTAERTQDNMEVRLDVKVSNEKETRALGIEVGDFISFDPRTVVTDTGFIKSR
                     HLDDKVSAAILLNLLRIYKKEKIELPVT"
BASE COUNT          159 a          111 c          140 g          154 t
ORIGIN      
        1 cactcgtgaa atttcgaatt atttagtcaa gactctagaa ggttttggtt accagccagt
       61 tcgcacagcc aagggtggtg tcaatgtgac catcaaaggt caaaatgatg ggcaacatcg
      121 ctatgtgact gcccatgtgg acacgctggg tgctattgtt cgtgctgtca aaccagatgg
      181 tcgtcttaaa ttggaccgta tcggtggttt tccttggaac atgattgaag gtgaaaactg
      241 taccgttcat gtggctagca caggtcaaaa ggtatcagga accatcctca tccaccaaac
      301 ttcttgccat gtctacaagg atgcaggaac tgcagaacgc acgcaggaca atatggaagt
      361 gcgtttggat gtaaaagtaa gcaatgaaaa agaaactcgt gctcttggga ttgaggtcgg
      421 tgattttatc agcttcgatc cacgaactgt tgtgactgat acaggtttta tcaagtctcg
      481 tcatttggat gataaggtca gcgcagcgat tttgctcaac ctgcttcgta tttataagaa
      541 agagaagatt gaattgccag taac
//
LOCUS       DBMVGT010000253          563 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.254, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000253 DBMVGT010000000
VERSION     DBMVGT010000253.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 563)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 563)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.254"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..177)
                     /locus_tag="AC0DU4_002317"
     CDS             complement(<1..177)
                     /locus_tag="AC0DU4_002317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine ABC transporter substrate-binding
                     protein"
                     /protein_id="HIN4238199.1"
                     /translation="MRKIYLSIFTSLLLMLGLINVAQADEYLRIGMEAAYAPFNWTQD
                     DDSNGAIKIDGTNQY"
     gene            316..>563
                     /locus_tag="AC0DU4_002318"
     CDS             316..>563
                     /locus_tag="AC0DU4_002318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2207 domain-containing protein"
                     /protein_id="HIN4238200.1"
                     /translation="MKKTFFLLMFGLFCLLPLSVFAIDFKINSYQGDLYIHADNTAEF
                     RQKIVYQFEEDFKGQIVGLGRAGKMPSGFDIDPHPKVQA"
BASE COUNT          169 a           96 c          109 g          189 t
ORIGIN      
        1 gtactggttg gttccatcga ttttgatagc tccattgcta tcatcatctt gggtccagtt
       61 aaagggagca tatgctgctt ccatcccgat gcgtaaatat tcatcggctt gagcaacatt
      121 gataagtcct agcatcagca agagacttgt gaaaatagat aagtatattt ttctcatgat
      181 ttctcctatt tctaatctat taaaaaataa ctgtctccta ttttatcgaa aaatgcgtaa
      241 tttttcaaca taagtaagcc tttacttacg aaaaaatgct ataatgataa gaaagataaa
      301 aagggggctt aattgatgaa aaaaactttt ttcttactga tgtttggctt gttttgcctt
      361 ctgccacttt ctgttttcgc cattgatttt aagataaact cttatcaagg tgatttgtat
      421 attcatgcag acaatacggc agaatttaga caaaagatag tttatcagtt tgaggaggac
      481 tttaagggac aaatcgtggg acttggacgt gctggtaaga tgcctagcgg gtttgacatt
      541 gaccctcatc caaaggttca ggc
//
LOCUS       DBMVGT010000254          559 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.255, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000254 DBMVGT010000000
VERSION     DBMVGT010000254.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 559)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 559)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.255"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            65..>559
                     /locus_tag="AC0DU4_002319"
     CDS             65..>559
                     /locus_tag="AC0DU4_002319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RICH domain-containing protein"
                     /protein_id="HIN4238201.1"
                     /translation="MFASKSERKVHYSIRKFSIGVASVAVASLVMGSVVHATENEGST
                     QAATFSNMANKSQTEQGEINIERDKAKTAVSEYKEKKVSEIYTKLERDRHKDTVDLVN
                     KLQEIKNEYLNKIVESTSKIEIQGLITTSRSKLDEAVSKYKKAPSSSSSSGSSTKPET
                     PQPET"
BASE COUNT          230 a           81 c          114 g          134 t
ORIGIN      
        1 ttatatacag ttcatattga agtgatatag taaggttaaa gaaaaaatat agaaggaaat
       61 aattatgttt gcatcaaaaa gcgaaagaaa agtacattat tcaattcgta aatttagtat
      121 tggagtagct agtgtagctg ttgccagtct tgttatggga agtgtggttc atgcgacaga
      181 gaacgaggga agtacccaag cagccacttt ttctaatatg gcaaataaaa gtcagacaga
      241 acaaggagaa atcaatatag aacgagataa ggcaaagaca gcggtcagtg aatataaaga
      301 aaaaaaagtg agtgagatct atacaaaatt agagagagat agacataaag atactgtaga
      361 tctagttaac aagttgcaag agattaagaa cgagtatttg aataaaatag ttgaatcaac
      421 ctcaaaaatc gaaatacagg gacttattac aacaagtcga tcaaaactag atgaagctgt
      481 gtctaaatat aaaaaggccc catcttcttc gtcaagttca ggctcctcca ctaaaccaga
      541 aactccgcag ccggaaaca
//
LOCUS       DBMVGT010000255          558 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.256, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000255 DBMVGT010000000
VERSION     DBMVGT010000255.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 558)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 558)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.256"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..253
                     /locus_tag="AC0DU4_002320"
     CDS             <1..253
                     /locus_tag="AC0DU4_002320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HIN4238202.1"
                     /translation="LPQAFRIILPPLTNQIVNLIKNTSTVAIISGVDLMFVTKSWSAL
                     NGNYIPAFLGAALLYFALCFPVAQFGRKMEQANKKAYSL"
     gene            263..>558
                     /locus_tag="AC0DU4_002321"
     CDS             263..>558
                     /locus_tag="AC0DU4_002321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443867.1"
                     /note="The N-terminal region of this protein, as described
                     by TIGR01726, is a three transmembrane segment that
                     identifies a subfamily of ABC transporter permease
                     subunits, which specificities that include histidine,
                     arginine, glutamine, glutamate, L-cystine (sic), the
                     opines (in Agrobacterium) octopine and nopaline, etc;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA];
                     GO_function: GO:0022857 - transmembrane transporter
                     activity [Evidence IEA];
                     GO_process: GO:0015837 - amine transport [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit"
                     /protein_id="HIN4238203.1"
                     /translation="MESILEILTPDNLVFIFKGFGLTLYISLIAIILSTIIGTVLAVM
                     RNGKNPILRIISSIYIEFVRNVPNLLWIFTIFLVFKMKSTPAGITAFTLFTSAA"
BASE COUNT          136 a          143 c           89 g          190 t
ORIGIN      
        1 cttgcctcag gccttccgca tcattctccc tccattgacc aaccaaattg ttaacctcat
       61 caagaacaca tctactgtag ctatcatctc tggagtagac ttgatgtttg tgactaagtc
      121 ttggtcggct ctcaacggaa actatatccc agccttttta ggtgctgctc ttctctactt
      181 tgccctatgc ttccctgttg cccagtttgg tcgcaagatg gagcaagcca ataaaaaagc
      241 ctattcactt taggaggtta ctatggaatc tattttagaa attttaaccc cagataacct
      301 agtctttatc tttaaaggat ttggcttgac cctctatatt tctctgattg ccatcatcct
      361 ctctactatc atcggtaccg tgcttgccgt catgcgaaat ggaaaaaatc ctatcttacg
      421 cattatttcc agtatttata tcgagtttgt gcgcaacgtt cccaaccttc tctggatttt
      481 tactatcttt ttggtgttca aaatgaaatc cacaccagca ggtattacag cctttactct
      541 ctttacatca gcagcctt
//
LOCUS       DBMVGT010000256          547 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.257, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000256 DBMVGT010000000
VERSION     DBMVGT010000256.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 547)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 547)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..547
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.257"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..306
                     /locus_tag="AC0DU4_002322"
     CDS             <1..306
                     /locus_tag="AC0DU4_002322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000062217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA];
                     GO_function: GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA];
                     GO_function: GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA];
                     GO_function: GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HIN4238204.1"
                     /translation="TLSGGEQQMLAMGRALMSTPKLLLLDEPSMGLAPIFIQEIFDII
                     QDIQKQGTTVLLIEQNANKALAISDRGYVLETGKIVLSGTGKELASSEEVRKAYLGG"
BASE COUNT          186 a          106 c          103 g          152 t
ORIGIN      
        1 actctttcag ggggggaaca acaaatgctt gccatgggac gcgccctcat gtcaacacca
       61 aaacttcttc ttttagatga accatcaatg ggacttgccc caatctttat ccaagaaatt
      121 tttgatatca ttcaagatat tcagaagcaa ggaacaacgg tcctcttgat tgaacaaaat
      181 gccaataaag cacttgcaat ctctgaccga ggatatgtac tggaaacagg gaaaatcgtc
      241 ctatcaggaa caggaaaaga actcgcttca tcagaagaag tcagaaaagc atatctaggt
      301 ggctaaaaca atccagtgga ttgttttagt cggcagatgg agattacgaa gtaatcatca
      361 atatagtccg ggggaccttt ttagtcggta gattgagatt gcaaacaaat ctgcatctac
      421 attgaaagct taatttctaa taattgaaaa aatcgaatga aaaatttctt accttcattc
      481 acagagctcg atttcagagc tctttttgct agcttattca tacttttctg aatttcgaaa
      541 aagaaat
//
LOCUS       DBMVGT010000257          540 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.258, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000257 DBMVGT010000000
VERSION     DBMVGT010000257.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 540)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 540)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.258"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>540
                     /locus_tag="AC0DU4_002323"
     CDS             <1..>540
                     /locus_tag="AC0DU4_002323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000950172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008184 - glycogen phosphorylase activity
                     [Evidence IEA];
                     GO_process: GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan phosphorylase"
                     /protein_id="HIN4238205.1"
                     /translation="LDEAISIVRSMTAYTNHTILAEALEKWPLEFLQEVVPHLVPIIE
                     ELDRRVKAEYKDPAVQIIDESGRVHMAHMDIHYGYSVNGVAALHTEILKNSELKAFYD
                     LYPEKFNNKTNGITFRRWLMHANPRLSHYLDEILGDGWHHEADELEKLLSYEDKAAVK
                     EKLESIKAHNKRKLARHLKE"
BASE COUNT          172 a          117 c          114 g          137 t
ORIGIN      
        1 cttgacgaag caatttcaat tgttcgtagc atgactgcct acactaacca cacaatcctt
       61 gctgaagcgc ttgaaaaatg gcctcttgaa ttcttgcaag aagtggttcc tcacttggta
      121 ccaatcatcg aagaattgga ccgtcgtgtg aaggcagagt acaaagatcc agctgttcaa
      181 atcatcgatg agagcggacg tgttcacatg gctcacatgg atatccacta cggatacagt
      241 gttaacgggg ttgcagcact ccatactgaa atcttgaaaa attctgagtt gaaagccttc
      301 tacgaccttt acccagaaaa gttcaacaac aaaacaaacg gtatcacttt ccgtcgttgg
      361 cttatgcatg ctaacccaag attgtctcac tacttggatg agattcttgg agatggttgg
      421 caccatgaag cagatgagct tgaaaaactt ttgtcttatg aagacaaagc agctgtcaaa
      481 gaaaaattgg aaagcatcaa ggctcacaac aaacgtaaat tggctcgtca cttgaaagaa
//
LOCUS       DBMVGT010000258          530 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.259, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000258 DBMVGT010000000
VERSION     DBMVGT010000258.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 530)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 530)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.259"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>530
                     /locus_tag="AC0DU4_002324"
     CDS             <1..>530
                     /locus_tag="AC0DU4_002324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HIN4238206.1"
                     /translation="KPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRH
                     DNADMRLTEMGREIGLVDDERWARFEIKKNQFDNEMKRLDSIKLKPVKETNAKVEEMG
                     FKPLTDAVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISKAMD
                     QVAKMKRMEEKRIPAN"
BASE COUNT          167 a          105 c          131 g          127 t
ORIGIN      
        1 aaacctgagt tgattctaaa acgaagtgac ggttatatcg gggtgatgat cgacgacttg
       61 gtgaccaagg gaaccattga accttaccgt ctcttgacca gtcgtgctga ataccgtctc
      121 attcttcgtc atgacaatgc tgatatgcgc ttgactgaga tgggacgcga gattggcctt
      181 gtggatgatg aacgctgggc tcgttttgaa atcaagaaaa atcaatttga taatgagatg
      241 aaacgcctag acagtatcaa actcaagcca gtcaaggaaa ccaatgctaa ggttgaggaa
      301 atgggcttca agccgttgac agatgcggtg acagccaaag aattccttcg ccgtccagaa
      361 gtttcttacc aagatgtggt ggccttcatc ggaccagctg cagaagactt ggatgacaag
      421 attatcgaat tgattgaaac agaaatcaag tacgaaggct atatttcaaa agccatggat
      481 caggttgcca agatgaaacg tatggaagaa aaacgcattc cagccaatat
//
LOCUS       DBMVGT010000259          526 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.260, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000259 DBMVGT010000000
VERSION     DBMVGT010000259.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 526)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 526)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.260"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>526)
                     /locus_tag="AC0DU4_002325"
     CDS             complement(<1..>526)
                     /locus_tag="AC0DU4_002325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_process: GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HIN4238207.1"
                     /translation="GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLK
                     LIDLLDGIDVYNDQEFTAHTNGKYYPEGNVHLDSEQALGFVRERYSLADGDRDRGRNQ
                     QKVIVAILQKLTSTEELKNYSTIIDSLQDSIQTNMPIETMIDLVNTQLESGGNYKVNS
                     QDLKGTGRMDLPSYA"
BASE COUNT          159 a          113 c           86 g          168 t
ORIGIN      
        1 gcataagaag gaagatccat ccgacctgtc ccttttaaat cttgagaatt tactttataa
       61 ttccctccac tttccaactg agtattcact aaatctatca tagtctcaat cggcatattt
      121 gtttggatag aatcttgcaa gctatcaatg atcgtactat aatttttcag ttcttcggtt
      181 gacgttaatt tttgaaggat agccacaatc accttttgtt gattgcgccc gcggtcacga
      241 tcgccatctg ctagggagta gcgctcacga acaaaaccga gagcctgttc tgaatcaaga
      301 tgaacattgc cttcagggta atactttcca ttcgtatggg cagtaaattc ttgatcatta
      361 taaacatcaa ttccatccaa caaatcaatc aatttcaaaa acgaagtgaa gttcaatcgt
      421 acatagtaat tgatatccac tccatagaga ttttctaagg tgtgaatgga cgaatcaact
      481 ccataaatgc ccgcatgagt caatttatct ttttgattat ttccac
//
LOCUS       DBMVGT010000260          524 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.261, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000260 DBMVGT010000000
VERSION     DBMVGT010000260.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 524)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.261"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            2..493
                     /locus_tag="AC0DU4_002326"
     CDS             2..493
                     /locus_tag="AC0DU4_002326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003677 - DNA binding [Evidence IEA];
                     GO_process: GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HIN4238208.1"
                     /translation="MVQLLMEQPFDKISTVKLVEKAGISRSSFYTHYKDKYDMIEHYQ
                     SKLFHTFEYIFQKHAHHKRDAILEVFEYLESEPLLAALLSENGTKEIQNFLRNKLHIM
                     LSTDLQKRFMQLNLNTTELEYSSIYLTHALFGVCQTWIAHGKKESSQEITDFLMKMLG
                     DTN"
BASE COUNT          192 a           92 c           82 g          158 t
ORIGIN      
        1 tatggtacaa ttactgatgg aacagccatt tgataaaatt tctactgtca aattagtaga
       61 aaaagccgga attagtcgtt ccagcttcta tactcactat aaggataagt atgatatgat
      121 tgagcactat caaagcaagc tattccatac atttgaatat atttttcaaa aacatgctca
      181 tcacaaaaga gacgctattt tagaagtttt tgaatatcta gagtcagaac cacttctggc
      241 tgcccttctt tctgaaaatg ggactaaaga aatccaaaat ttcttacgaa ataaacttca
      301 tatcatgctt agtacagatt tacaaaagcg atttatgcaa ctgaatctaa ataccactga
      361 attagaatat agtagcatct atctaactca tgcacttttt ggtgtctgcc aaacttggat
      421 tgcacatgga aaaaaagaaa gttctcaaga aataacagac ttccttatga aaatgcttgg
      481 tgatacaaat tgatacaaaa agaggaacac agctgtgttc cctt
//
LOCUS       DBMVGT010000261          523 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.262, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000261 DBMVGT010000000
VERSION     DBMVGT010000261.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 523)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.262"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..117
                     /locus_tag="AC0DU4_002327"
     CDS             <1..117
                     /locus_tag="AC0DU4_002327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HIN4238209.1"
                     /translation="WTLLGQVLLYVALFFTIYSGYDYFKGSAYVFKGTFGSK"
     gene            114..>523
                     /locus_tag="AC0DU4_002328"
     CDS             114..>523
                     /locus_tag="AC0DU4_002328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HIN4238210.1"
                     /translation="MKSIIDVKNLSFRYKENQNYYDVKDITFHVKRGEWLSIVGHNGS
                     GKSTTVRLIDGLLEAESGEIVIDGQRLTEENVWNIRRQIGMVFQNPDNQFVGATVEDD
                     VAFGLENQGLSRQEMKKRVEEALALVGMLDFKKR"
BASE COUNT          159 a           70 c          125 g          169 t
ORIGIN      
        1 tggactttgc ttggtcaagt tctactttat gtagccttat ttttcactat ctactctggc
       61 tatgactatt tcaagggtag tgcctatgta tttaaaggga catttggttc gaaatgaaat
      121 caataattga tgtaaaaaat ctttcttttc gctataaaga aaatcagaac tactacgatg
      181 tgaaggatat tacgtttcac gtgaaacgtg gagaatggct ttcgattgta gggcataatg
      241 gtagtggtaa atcaactacg gttcgattaa ttgatggctt actggaagca gaatccggag
      301 agattgtaat tgatggccaa cgtttgactg aggaaaatgt ttggaatata cgtcgtcaaa
      361 tcggtatggt ttttcaaaat ccagacaatc aatttgttgg agcgactgtt gaagatgatg
      421 ttgcttttgg tttggaaaat cagggacttt ctcgtcaaga aatgaaaaag agagtggaag
      481 aagctctggc tttagttggc atgttggact ttaaaaagag aga
//
LOCUS       DBMVGT010000262          519 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.263, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000262 DBMVGT010000000
VERSION     DBMVGT010000262.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 519)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.263"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..167
                     /locus_tag="AC0DU4_002329"
     CDS             <1..167
                     /locus_tag="AC0DU4_002329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003723 - RNA binding [Evidence IEA];
                     GO_function: GO:0008173 - RNA methyltransferase activity
                     [Evidence IEA];
                     GO_process: GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="TrmH family RNA methyltransferase"
                     /protein_id="HIN4238211.1"
                     /translation="KIALIIGNEGKGISSNIKKQVDEMITIPMNGHVQSLNASVAAAI
                     LMYEVFRNRL"
     gene            complement(205..>519)
                     /locus_tag="AC0DU4_002330"
     CDS             complement(205..>519)
                     /locus_tag="AC0DU4_002330"
                     /EC_number="1.-.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HIN4238212.1"
                     /translation="REIKGENRVESVVFENVKTGQVTEQVFGGVFIYVGLDPLSDFVK
                     ELNIQDQAGWIVTDNHMKTAVDGIFAVGDVRLKDLRQVTTAVGDGAIAGQEAYKFITE
                     HS"
BASE COUNT          152 a          117 c           90 g          160 t
ORIGIN      
        1 ggaaaatcgc cctcatcatt ggaaatgaag gaaaaggtat ctctagcaac atcaaaaaac
       61 aagtcgatga gatgattacc attccgatga atggacatgt tcaaagcctt aatgccagtg
      121 ttgctgcggc cattctcatg tacgaagttt tccgaaatag actataaaaa gtttccagtc
      181 atctgattgg aaactttttt ataattaact atgttctgta atgaatttat aggcttcttg
      241 accagcgata gctccatctc caaccgctgt tgttacttgg cgaaggtctt tcaagcgaac
      301 atctccaact gcaaagatac cgtcgactgc agttttcatg tggttatctg tcacaatcca
      361 tcctgcctga tcttggatat tcaattcttt aacaaaatcg ctaagagggt ccaatccaac
      421 atagataaag acaccaccga agacttgttc tgtcacttga cctgttttca cattttcaaa
      481 tacgactgat tctactcggt tttcaccctt gatttccct
//
LOCUS       DBMVGT010000263          514 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.264, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000263 DBMVGT010000000
VERSION     DBMVGT010000263.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 514)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.264"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>514
                     /locus_tag="AC0DU4_002331"
     CDS             <1..>514
                     /locus_tag="AC0DU4_002331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HIN4238213.1"
                     /translation="DADLPIQLELDLGSPKTFDVIELREDLKLGQRIAAFHVQVEVDG
                     VWQEFGRGFTVGHKRLLRGPLVEAQKVRVMITEAQSIPVLIKISLYKTPGLSKKEVVQ
                     ELAFAEKSLAVAKGETLHFRIERSESSSSLEAKISIQPGTGVHGVAYQDEIYVLAFQA
                     GETEKRLTLPT"
BASE COUNT          144 a           99 c          133 g          138 t
ORIGIN      
        1 cgatgcagac ttgcccatcc agttagaact cgacttaggt tctcctaaaa cttttgatgt
       61 aattgagtta agagaagatt tgaagctagg gcaacgaatc gctgcttttc atgtgcaagt
      121 agaggtggat ggtgtctggc aggaatttgg caggggcttc acagttggtc ataagcgcct
      181 cttgcgaggt ccgctagtag aggcacaaaa ggtgcgcgtg atgattaccg aggcacaatc
      241 tattcctgta ttgatcaaga tttcccttta taaaactcct ggattatcaa aaaaagaagt
      301 tgttcaggaa ctagcatttg cagaaaaaag cctagctgtg gcaaagggag agactcttca
      361 ttttaggatt gaacgtagtg aaagtagctc ctctttagag gctaagattt cgattcaacc
      421 ggggacaggt gtccatggtg tcgcctatca ggacgagatt tatgtccttg cgtttcaagc
      481 tggtgagact gaaaaaaggc tgacgctacc aacc
//
LOCUS       DBMVGT010000264          504 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.265, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000264 DBMVGT010000000
VERSION     DBMVGT010000264.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 504)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.265"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>504
                     /gene="tsf"
                     /locus_tag="AC0DU4_002332"
     CDS             <1..>504
                     /gene="tsf"
                     /locus_tag="AC0DU4_002332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003746 - translation elongation factor
                     activity [Evidence IEA];
                     GO_process: GO:0006414 - translational elongation
                     [Evidence IEA]"
                     /codon_start=2
                     /transl_table=11
                     /product="translation elongation factor Ts"
                     /protein_id="HIN4238214.1"
                     /translation="QLSMHIAAMKPTVLSYKELDEQFVKDELAQLNHVIDQDNESRAM
                     VNKPALPHLKYGSKAQLTDDVIAQAEADIKAELAAEGKPEKIWDKIIPGKMDRFMLDN
                     TKVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKAANDFEAEVAA
                     TMAAALN"
BASE COUNT          172 a           99 c          107 g          126 t
ORIGIN      
        1 acaattgtca atgcacatcg cagcgatgaa accaacagtt ctttcttaca aagaattgga
       61 tgagcaattc gttaaagatg agttggcaca attgaatcac gttatcgacc aagacaacga
      121 aagccgtgca atggttaata aaccagctct tccacacttg aagtatggat caaaagctca
      181 attaactgat gatgttattg ctcaagctga agctgacatc aaagctgaat tggctgcaga
      241 aggcaaacca gaaaaaatct gggacaaaat tattccaggt aaaatggatc gcttcatgct
      301 tgataacact aaagttgacc aagcttacac acttcttgca caagtttaca tcatggatga
      361 cagcaagaca gttgaagcat accttgaatc agttaacgct tcggtagttg agtttgctcg
      421 ctttgaagtt ggtgaaggta tcgagaaagc tgcaaacgac ttcgaagctg aagttgcagc
      481 tacaatggca gcagccttga ataa
//
LOCUS       DBMVGT010000265          499 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.266, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000265 DBMVGT010000000
VERSION     DBMVGT010000265.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 499)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.266"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>499
                     /locus_tag="AC0DU4_002333"
     CDS             <1..>499
                     /locus_tag="AC0DU4_002333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="HIN4238215.1"
                     /translation="EIQVAKLAGKYTTEDGYIFDPRDITSDEGDAYVTPHMTHSHWIK
                     KDSLSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKGAEAIYNRVKAAKKVPLDRMP
                     YNLQYTVEVKNGSLIIPHYDHYHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPN
                     ERPHS"
BASE COUNT          161 a          104 c          113 g          121 t
ORIGIN      
        1 atgagattca agtagccaag ttggcaggca agtacacaac agaagacggt tatatctttg
       61 atcctcgtga tataaccagt gatgaggggg atgcctatgt aactccacat atgacccata
      121 gccactggat taaaaaagat agtttgtctg aagctgagag agcggcagcc caggcttatg
      181 ctaaagagaa aggtttgacc cctccttcga cagaccatca ggattcagga aatactgagg
      241 caaaaggagc agaagctatc tacaaccgcg tgaaagcagc taagaaggtg ccacttgatc
      301 gtatgcctta caatcttcaa tatactgtag aagtcaaaaa cggtagttta atcatacctc
      361 attatgacca ttaccataac atcaaatttg agtggtttga cgaaggcctt tatgaggcac
      421 ctaaggggta tactcttgag gatcttttgg cgactgtcaa gtactatgtc gaacatccaa
      481 acgaacgtcc gcattcaga
//
LOCUS       DBMVGT010000266          493 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.268, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000266 DBMVGT010000000
VERSION     DBMVGT010000266.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 493)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.268"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            39..>493
                     /locus_tag="AC0DU4_002334"
     CDS             39..>493
                     /locus_tag="AC0DU4_002334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008233 - peptidase activity [Evidence
                     IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="HIN4238216.1"
                     /translation="MKKRYLVVTALLALSLAACSQEKAKNEDGTAKTEQTAKADGTVG
                     SKSQGAAQKKAEVVNKGDYYSIQGKYDEIIVANKHYPLSKDYNPGENPTAKAELVKLI
                     KAMQEAGFPISDHYSGFRSYETQTKLYQDYVNQDGKAAADRYSARPGYS"
BASE COUNT          180 a           98 c          113 g          102 t
ORIGIN      
        1 tcagaagtag ataaactatt agaaataaag gagtagaaat gaagaaaaga taccttgtcg
       61 tgacagcctt gctagccttg agtctagcag cttgttcaca agaaaaagca aaaaatgaag
      121 atggcacagc taagacagaa cagacagcca aagctgatgg gacagtcggc agtaagtctc
      181 aaggggctgc ccagaaaaaa gcagaagtgg tcaataaagg tgattactac agcatccaag
      241 gaaaatacga cgaaatcatc gtagccaata aacattatcc tttgtcgaaa gactataatc
      301 ccggggaaaa tccaacagcc aaggctgagt tggtcaaact catcaaagcg atgcaagagg
      361 caggtttccc tattagtgat cattacagtg gttttagaag ttatgaaact cagaccaagc
      421 tctatcaaga ttatgtcaac caagatggaa aggcagcagc tgaccgttac tctgcccgtc
      481 ctggctatag cga
//
LOCUS       DBMVGT010000267          492 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.269, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000267 DBMVGT010000000
VERSION     DBMVGT010000267.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 492)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.269"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..360
                     /locus_tag="AC0DU4_002335"
     CDS             <1..360
                     /locus_tag="AC0DU4_002335"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220605.1"
                     /note="Catalyzes first step of the de novo purine
                     nucleotide biosynthetic pathway; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HIN4238217.1"
                     /translation="RGTTSRRIVQLLKEAGATEVHVAIGSPALAYPCFYGIDIQTRQE
                     LIAANHTVEETRQIIGADSLTYLSIDSLIESIGIETDAPNGGLCVAYFDGDYPTPLYD
                     YEEDYRRSLEEKTSFYK"
BASE COUNT          142 a          101 c          126 g          123 t
ORIGIN      
        1 cgtggaacaa cctctcgtcg tatcgttcag ctcttgaaag aagcgggtgc gactgaggtt
       61 cacgttgcca ttggaagtcc tgcactagcg tatccatgtt tctacgggat tgatatccag
      121 acccgtcagg agctgattgc agccaatcat acggtcgaag aaactcgcca aatcattggt
      181 gcggacagtc tgacttatct ttcaattgat agcttgattg agtcgattgg tatcgaaaca
      241 gatgcgccga acggtggtct ctgtgtcgct tactttgacg gtgactaccc aacgcctctc
      301 tatgactacg aagaagacta tcgtagaagt ttggaagaaa agaccagttt ttacaagtag
      361 gcgacagatt ctccattaaa gaaaaggaaa aaacaaatga caaataaaaa tgcatatgcc
      421 cagtcgggtg tggatgttga agcgggttat gaagttgttg aacggattaa aaagcacgtg
      481 gcccgtacgg ag
//
LOCUS       DBMVGT010000268          478 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.270, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000268 DBMVGT010000000
VERSION     DBMVGT010000268.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 478)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.270"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            1..478
                     /locus_tag="AC0DU4_002336"
                     /pseudo
     CDS             1..478
                     /locus_tag="AC0DU4_002336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002881980.1"
                     /note="internal stop; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="radical SAM protein"
BASE COUNT          135 a           91 c          116 g          136 t
ORIGIN      
        1 cagactgttt accagacgaa accatcgaat atttggctga gttatcggag tgcatgcatg
       61 tgacggttga attgggcttg cagacaactt atgaagcaac ctctgacctg attaaccgtg
      121 tgcattctta tgaattgtag gtggaaacgg tcaagcgttt gagaaagtat cccaagattg
      181 agattgtttc ccatttgatc aatggtttgc ctggtgaaac ccatgagatg atggttgaaa
      241 atgtccgccg ttgtgtcacg gataacgata ttcaagggat taaactgcat ttgctccatc
      301 ttatgacaaa tactcgtatg caacgagatt accatgaggg acgtttacaa ttgatgagtc
      361 aggacgaata tgtcagggtc atctgtgacc aactggaaat tattcccaaa catatcgtca
      421 tccatcgaat tacaggagat gcgcctaggg atatgctgat tggtcctatg tggagcct
//
LOCUS       DBMVGT010000269          476 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.271, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000269 DBMVGT010000000
VERSION     DBMVGT010000269.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 476)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.271"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(400..>476)
                     /locus_tag="AC0DU4_002337"
     CDS             complement(400..>476)
                     /locus_tag="AC0DU4_002337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001066288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="DnaJ C-terminal domain-containing protein"
                     /protein_id="HIN4238218.1"
                     /translation="AGDLKVNPKKKGFFDHIKDAFDGE"
BASE COUNT          155 a           94 c           93 g          134 t
ORIGIN      
        1 aaccataccc atgacaagcc gacgctgacg tggtttgaag aaatttttga agagtatcat
       61 tcaccatttc acaactaaat cgaagacttt ctgccgtaat gaaaacacct gaaacagctt
      121 ggtttcagct gtccggaaac tttaagactt aggttcaaag tttaggtatg gaacttcgaa
      181 ggaggtcgct accgtccgtc attacttagg aaagtcttaa aaaatctata aagtaaaaag
      241 agcccgacag ctctttttgt ttatactcaa tgaaaatcaa aaagcaaact aggaaactag
      301 ccacgggctg ctcaaaacac tgttttgagg ttgtagatac gactcacata tatacggcaa
      361 ggcaacgctg acgtggtttg aagagatttt cgaagagtat tattctccat caaaggcatc
      421 ttttatatgg tcaaagaagc cttttttctt tggatttact ttcaagtcac cagcag
//
LOCUS       DBMVGT010000270          466 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.272, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000270 DBMVGT010000000
VERSION     DBMVGT010000270.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 466)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.272"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>466
                     /locus_tag="AC0DU4_002338"
     CDS             <1..>466
                     /locus_tag="AC0DU4_002338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=3
                     /transl_table=11
                     /product="GTPase"
                     /protein_id="HIN4238219.1"
                     /translation="NDIYDFYALGLGEPLPISSVHGIGTGDVLDAIVENLPNEYEEEN
                     PDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFTDTDGQEFTMID
                     TAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDKRIAGFA"
BASE COUNT          127 a           85 c          116 g          138 t
ORIGIN      
        1 gaaatgatat ctatgatttc tatgccctcg gtttgggtga accactgcct atctcatctg
       61 tccatggtat cggtacaggg gatgtactag atgcgattgt ggaaaacctt ccaaatgaat
      121 atgaagaaga aaatccagat gtcattaagt ttagcttgat tggtcgtcct aacgttggaa
      181 aatcaagctt gattaatgct atcttgggag aagaccgtgt cattgccagt cctgttgctg
      241 gaacaactcg tgacgctatt gatacccact ttacagatac agatggtcaa gagtttacca
      301 tgattgatac ggctggtatg cgtaagtctg gtaaggttta tgaaaatact gagaagtact
      361 ctgtcatgcg tgccatgcgt gctattgacc gttcagatgt ggtcttaatg gtcatcaatg
      421 cggaagaggg gattcgtgaa tacgacaaac gtatcgctgg atttgc
//
LOCUS       DBMVGT010000271          465 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.273, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000271 DBMVGT010000000
VERSION     DBMVGT010000271.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 465)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.273"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..438
                     /locus_tag="AC0DU4_002339"
     CDS             <1..438
                     /locus_tag="AC0DU4_002339"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0003824 - catalytic activity [Evidence
                     IEA];
                     GO_function: GO:0016836 - hydro-lyase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HIN4238220.1"
                     /translation="LTDEIIDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVA
                     LLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEK
                     RKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNMDKSGKK"
BASE COUNT          123 a          102 c          114 g          126 t
ORIGIN      
        1 ctgacagatg aaatcattga tggcgatgta gtcgttgttc gttttgttgg acctaaaggt
       61 ggtcctggta tgcctgagat gctgtcactt tcttcaatga ttgttggtaa aggtcaggga
      121 gataaggtgg ccctcttgac ggacggacgt ttctctggtg gtacttatgg tctggttgtt
      181 ggacatatcg ctcctgaagc tcaggatggt ggaccaattg cctatctccg taccggcgat
      241 atcgttacgg ttgaccaaga taccaaagaa atttccatgg ccgtatccga agaagaactt
      301 gaaaaacgca aggcagaaac aaccttgcca ccactttaca gccgtggtgt cctcggtaaa
      361 tatgcccaca tcgtatcatc tgcttcacgc ggagccgtga cagacttctg gaatatggac
      421 aagtcaggta aaaaataaac tcatactcga aaatctcttc aaatc
//
LOCUS       DBMVGT010000272          447 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.274, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000272 DBMVGT010000000
VERSION     DBMVGT010000272.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 447)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.274"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(62..147)
                     /locus_tag="AC0DU4_002340"
     tRNA            complement(62..147)
                     /locus_tag="AC0DU4_002340"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(111..113),aa:Leu,seq:taa)
     gene            complement(155..226)
                     /locus_tag="AC0DU4_002341"
     tRNA            complement(155..226)
                     /locus_tag="AC0DU4_002341"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(192..194),aa:Gly,seq:gcc)
     gene            complement(249..321)
                     /locus_tag="AC0DU4_002342"
     tRNA            complement(249..321)
                     /locus_tag="AC0DU4_002342"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(286..288),aa:Thr,seq:tgt)
     gene            complement(340..421)
                     /locus_tag="AC0DU4_002343"
     tRNA            complement(340..421)
                     /locus_tag="AC0DU4_002343"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(385..387),aa:Leu,seq:tag)
BASE COUNT          105 a          134 c           98 g          110 t
ORIGIN      
        1 tctaaccgcc tgattcgtag tcaggtactc tatccagttg agctaagggt gctccatatt
       61 atgccgagga ccggaatcga accggtacga tcgttaccaa tcgcaggatt ttaagtcctg
      121 tgcgtctgcc agttccgcca ccccggcctc tctaagcgaa cgacgggatt cgaacccgcg
      181 acccccacct tggcaaggtg gtgttctacc actgaactac gttcgcactg ttttcttcta
      241 tctaaaaatg ccggctacat gacttgaaca cgcgaccctc tgattacaaa tcagatgctc
      301 taccaactga gctaagccgg ctcatttgtt atatcttaat gcgggttaag ggacttgaac
      361 ccccacgccg ttaagcgcca gatcctaaat ctggtgcgtc tgccaattcc gccaaacccg
      421 catatatgac ccgtactggg ctcgaac
//
LOCUS       DBMVGT010000273          445 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.275, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000273 DBMVGT010000000
VERSION     DBMVGT010000273.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 445)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.275"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>445
                     /locus_tag="AC0DU4_002344"
     CDS             <1..>445
                     /locus_tag="AC0DU4_002344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HIN4238221.1"
                     /translation="LPEHLSTVTGELTSQETDGWYTLANTSSSRIYLKQAFQENSNLL
                     EQVVEPLTIITGGHNHKDQLTYAWKTLLQNAPHDSICGCSVDEVHREMETRFAKVNQV
                     GNFVKSNLLNEWKGKIATDKAQSDYLFTVINTGLHDKVDTVSTVID"
BASE COUNT          137 a          101 c           98 g          109 t
ORIGIN      
        1 cttcctgaac acttatcaac tgttacaggc gagttgacca gtcaggaaac agatggctgg
       61 tacacacttg ccaacacttc ttcatcccgc atttacctaa aacaagcctt ccaagaaaat
      121 agcaacctcc tagagcaagt ggtagaaccc ttgactatta tcactggtgg acacaaccac
      181 aaggaccagt tgacctatgc ttggaaaaca cttttgcaga atgcgccaca tgatagtatc
      241 tgtggctgta gcgtggacga agttcaccgc gagatggaaa cgcgttttgc caaggtcaac
      301 caagtaggaa actttgttaa aagtaacttg ctcaacgagt ggaagggtaa aattgctacg
      361 gataaggctc aaagtgacta tctctttact gtcattaaca caggcttgca tgataaggtc
      421 gatactgtca gcacagtgat tgatg
//
LOCUS       DBMVGT010000274          442 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.276, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000274 DBMVGT010000000
VERSION     DBMVGT010000274.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 442)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 442)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.276"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..234
                     /locus_tag="AC0DU4_002345"
     CDS             <1..234
                     /locus_tag="AC0DU4_002345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4238222.1"
                     /translation="FLPKELFEKTICFYTDEETELKRRLARDTTVRNRDASFILASHQ
                     MRREQYLRYYKETESKADILVDQSEDKFDVKRT"
BASE COUNT          154 a           80 c           94 g          114 t
ORIGIN      
        1 tttctaccca aggaactctt tgaaaaaacc atctgtttct acacggatga ggagaccgaa
       61 ttaaagcgac gccttgctag agatacgact gtgagaaatc gtgatgcatc ctttatattg
      121 gctagccatc agatgagacg ggagcagtat ctgcgatact ataaagaaac tgagtctaag
      181 gcggatatct tagtggatca atcagaagat aaatttgatg tcaagaggac ttaacttatg
      241 tatagaagaa atatagaaga aaatccctaa ttttaggaag aaaaagtagg aaaacagttt
      301 catcccaaaa aaacgaaaaa acctaacaaa tcccttgcaa tcgcagggga tttgtgttat
      361 tctattatgg tgctgtaaat tacagcctta gttttgatac aagaggttgc gacacgctcg
      421 gttgcattgc cacgcaacac cg
//
LOCUS       DBMVGT010000275          438 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.277, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000275 DBMVGT010000000
VERSION     DBMVGT010000275.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 438)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.277"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>438)
                     /locus_tag="AC0DU4_002346"
     CDS             complement(<1..>438)
                     /locus_tag="AC0DU4_002346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_component: GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HIN4238223.1"
                     /translation="GISLVFWIFVQTLFLLLFAPLFLVMGYGLPVFLVYVLLLGVGKY
                     FLFRQKASKFFTETGLDWDYVISQESKRKQVLLRFFALFTQVKGISNSVKRRAYLDFI
                     LKVVQKVSGKIWQNLYLRSYLRNGDLFALSLRLLLLSLLAQVFI"
BASE COUNT          165 a           98 c           92 g           83 t
ORIGIN      
        1 gataaagacc tgcgccagca aagaaagcaa gagcagacgg agactaaggg caaaaaggtc
       61 tccatttcgc aaataagaac gcagatagag attttgccaa atcttcccag acaccttctg
      121 aacaaccttt agaataaagt ccagataggc acgacgcttg acgctgtttg aaattccctt
      181 gacctgcgta aagagggcaa agaaacgaag caagacttgc ttacgcttgc tttcttggga
      241 aatgacatag tcccaatcca gtccagtttc agtgaaaaat ttgctggcct tttgacgaaa
      301 gaggaaatat tttcctaccc ccaataaaag cacatagacc agaaaaacag gcaagccata
      361 acccatgact aaaaacaagg gcgcaaataa cagcaagaag agggtctgaa caaaaatcca
      421 aaagactagg gaaatgcc
//
LOCUS       DBMVGT010000276          436 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.279, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000276 DBMVGT010000000
VERSION     DBMVGT010000276.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 436)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.279"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>436)
                     /locus_tag="AC0DU4_002347"
     CDS             complement(<1..>436)
                     /locus_tag="AC0DU4_002347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HIN4238224.1"
                     /translation="NTVLSRLGDLSLPCPQDEDLTILPHSAYSETLYQAGSWSHKRRV
                     CQFSERKEGNLFYDVISLVTNMTSGTSQDQFQLYRGRGQAENFIKEMKEGFFGDKTDS
                     STLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLF"
BASE COUNT          123 a           87 c          105 g          121 t
ORIGIN      
        1 aaaaagatgg cggaagcgtt tgattgttaa agtttggaag tcacctccag ctagatgttt
       61 gagaaaaaga tagagattgt aggcgataca gctcatcatc atacgaactt cgtttttgat
      121 taaggttgaa ctatccgttt tatcgccaaa aaatccctcc ttcatctcct tgatgaaatt
      181 ctcggcttga ccacgtccac gataaagctg aaactggtct tggcttgttc cactcgtcat
      241 atttgtaacg agagaaataa catcgtagaa caagtttcct tcttttcgtt cagagaactg
      301 gcagacacga cgcttgtgcg accaagatcc tgcttgatag agagtttctg agtaggcgga
      361 gtggggcaag atggttaagt cctcatcctg tgggcaaggg agggaaaggt ctccaagacg
      421 gctcagaaca gtattt
//
LOCUS       DBMVGT010000277          429 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.280, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000277 DBMVGT010000000
VERSION     DBMVGT010000277.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 429)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 429)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.280"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..167)
                     /locus_tag="AC0DU4_002348"
     CDS             complement(<1..167)
                     /locus_tag="AC0DU4_002348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside phosphorylase"
                     /protein_id="HIN4238225.1"
                     /translation="MIQKHAIPILEFDDNPQAVIMPNHEGLDLQLPKKCVYAFLGEEI
                     DRYAREVGADCV"
     gene            216..398
                     /locus_tag="AC0DU4_002349"
                     /pseudo
     CDS             216..398
                     /locus_tag="AC0DU4_002349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691454.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-disulfide reductase"
BASE COUNT          136 a          108 c           80 g          105 t
ORIGIN      
        1 acacaatccg cccctacttc ccttgcatag cggtcaatct cctcacctaa aaatgcataa
       61 acacacttct ttggcaactg caagtccagc ccctcgtgat tgggcatgat aaccgcctga
      121 ggattgtcat caaactctaa aataggaatc gcatgtttct gaatcatagc ctgcctcctc
      181 taattttgta ctattgtatc aaaaactgac aaagtgtcaa ggaggaaact gatgaactgg
      241 acaaaaaaca agcctacatc gtcagctgcc acagtggttt gcgcagctat atcgcagagc
      301 ctatcctcaa gcaagcagga tttaccgccc aaaaccttga cggcgcttat tcactataca
      361 aaatggttaa cccagaagga gtagaatatg gaaactagta tcagcatggc tgacttttat
      421 ggaaaatac
//
LOCUS       DBMVGT010000278          408 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.281, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000278 DBMVGT010000000
VERSION     DBMVGT010000278.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 408)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 408)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.281"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..254)
                     /locus_tag="AC0DU4_002350"
     CDS             complement(<1..254)
                     /locus_tag="AC0DU4_002350"
                     /EC_number="3.5.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0019239 - deaminase activity [Evidence
                     IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HIN4238226.1"
                     /translation="MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRG
                     HNAREELQRAVMHAEIMAIEDANLSEESWRLLDCTLFVTI"
BASE COUNT          122 a          105 c           58 g          123 t
ORIGIN      
        1 tcaatggtca caaaaagtgt gcaatccagc aagcgccagc tctcctcact caagttcgca
       61 tcctctatag ccataatttc cgcatgcata accgctcgct gtaattcctc acgcgcatta
      121 tgcccacgac caatgatttc cccatctttg acaatcacac aaccaattgg aatttcatcg
      181 tgttcaagag caatctcagc ctctctcaaa gcctccctca taaagacttc tttttcttca
      241 agcgtataat acatctcttt tctcttttcc tacttatcga ttttattatt atatcatgaa
      301 tcccaacaca aaaaaagcca ccgaatgcgg tgactctata gggagattat tatgaaaaag
      361 aaaagtttag gatatttgtt acaacaagtt aggaggtctt cttgtaac
//
LOCUS       DBMVGT010000279          401 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.282, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000279 DBMVGT010000000
VERSION     DBMVGT010000279.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 401)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 401)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.282"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(146..>401)
                     /locus_tag="AC0DU4_002351"
     CDS             complement(146..>401)
                     /locus_tag="AC0DU4_002351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="YfhO family protein"
                     /protein_id="HIN4238227.1"
                     /translation="YDVQQDTSIFFTIPYDKGWSAYQDGKKIEIKQAQTGFMKVDIPK
                     GKGTITLSFIPNGFITGAICSFTSLLLFGIYNHRRKSSKA"
BASE COUNT          131 a           66 c           75 g          129 t
ORIGIN      
        1 tcgggattac gacaaacaat ctctatcaac aagtcatttt cctagctgtc atactagctc
       61 tatttactgg tttaggtatg ctagcctatc aacataagaa aatggaagaa gattaaaaaa
      121 atcgaccgat taactggtcg attttttatg ccttagatga ctttcgtctg tgattataga
      181 ttccaaatag taagagagaa gtaaaggaac agattgctcc agtaataaaa ccattgggaa
      241 tgaaggaaag tgtaatagtt cctttcccct tgggaatgtc aactttcata aatccagttt
      301 gagcttgttt aatttctatt ttcttaccat cttggtaggc agaccaacct ttgtcataag
      361 gaatggtgaa gaaaatagat gtatcttgtt ggacatcata t
//
LOCUS       DBMVGT010000280          392 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.284, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000280 DBMVGT010000000
VERSION     DBMVGT010000280.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 392)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 392)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.284"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>392
                     /locus_tag="AC0DU4_002352"
     CDS             <1..>392
                     /locus_tag="AC0DU4_002352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="HIN4238228.1"
                     /translation="CEHVVNNMRHTKTVGVIEEDDVTGLTLIAEPVGVVCGITPTTNP
                     TSTAIFKSLISLKTRNPIVFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQWITQPS
                     MEATSALMNHEGVATILATGGNAMVKAA"
BASE COUNT          115 a           95 c           82 g          100 t
ORIGIN      
        1 tgtgaacacg tagtaaacaa catgcgccac actaagacag ttggcgttat cgaagaagac
       61 gatgtaacag gattgactct tattgctgaa ccagttggtg ttgtttgtgg tattactcca
      121 acaacaaacc caacatcaac agcaatcttc aaatcattga tttcattgaa gacacgtaac
      181 ccaatcgtct ttgccttcca tccatcagca caagaatcat ctgctcatgc agctcgtatc
      241 gtccgcgatg cagctatcgc agctggtgct cctgaaaact gtgtgcaatg gattactcaa
      301 ccatctatgg aagcaacaag tgcccttatg aaccacgaag gtgttgcgac aatccttgca
      361 acaggtggta atgccatggt taaggcggct ta
//
LOCUS       DBMVGT010000281          384 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.285, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000281 DBMVGT010000000
VERSION     DBMVGT010000281.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 384)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 384)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.285"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>384
                     /locus_tag="AC0DU4_002353"
     CDS             <1..>384
                     /locus_tag="AC0DU4_002353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
                     /protein_id="HIN4238229.1"
                     /translation="KLLDIKDPNIKILDIINMDTHKEIIAKLDYEAPSCPDCGSLMKK
                     YDFQKPSKIPYLETTGMPTRILLRKRRKRRFKCYHCSKMMVAETSIVKKNHQIPRIIN
                     QKIAQKLIEKISMTDIAHQLAISTST"
BASE COUNT          131 a           84 c           62 g          107 t
ORIGIN      
        1 aaactgctcg atattaaaga cccaaacatc aagattctag acatcatcaa tatggatacc
       61 cacaaagaaa ttatcgctaa gctggattat gaggctccat cttgccctga ttgtggaagt
      121 ctaatgaaga aatatgactt tcaaaaaccg tctaagatcc cttacctcga aacaactggt
      181 atgcctacta gaattctcct tagaaagcgt cgaaagcgtc gtttcaagtg ctatcattgt
      241 tctaaaatga tggtcgctga aacttctatc gtcaagaaaa atcaccaaat tcctcgtatt
      301 atcaaccaaa aaattgcgca aaagttgatt gagaagattt ctatgaccga tattgctcat
      361 cagctggcca tttcaacttc aact
//
LOCUS       DBMVGT010000282          361 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.286, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000282 DBMVGT010000000
VERSION     DBMVGT010000282.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 361)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 361)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.286"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..361)
                     /locus_tag="AC0DU4_002354"
                     /pseudo
     CDS             complement(1..361)
                     /locus_tag="AC0DU4_002354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518194.1"
                     /note="internal stop; incomplete; missing N-terminus and
                     C-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="YhgE/Pip family protein"
BASE COUNT          130 a           72 c           60 g           99 t
ORIGIN      
        1 cagggattaa tagatctaaa gaaatcattt gtcaaagcaa gtggataagt acctgcactt
       61 gatgctaact gtagtaaaag caaaataagt gagaaaaaag ctcctatacg gctattccac
      121 gttgctaaag tggtcaccat agacatgaat actaaacttg ttaggatgat gagaataaat
      181 attctcatct catgattagc agttaaacca ataagctgaa ctcctccata taccaaaatt
      241 cctgccaaaa cagctataat accatttatt tcagctcaag atttcaacca agcccaacgg
      301 ctctctggat gacgtcctga aggcaatttc gcaaatatca tatttgttga tattgctgca
      361 a
//
LOCUS       DBMVGT010000283          359 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.287, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000283 DBMVGT010000000
VERSION     DBMVGT010000283.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 359)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 359)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.287"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>359
                     /locus_tag="AC0DU4_002355"
     CDS             <1..>359
                     /locus_tag="AC0DU4_002355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HIN4238230.1"
                     /translation="LKGHEVLENTARYAKILLKHELTVPVSADEKLEEEQKGIIEFMK
                     REAGRSEELTNIPLETELTVFVDNPQIRFKTRFTNTAKDHRIRLLVKTHNTRPSNDSE
                     SIYEVVTRPNKPAASWE"
BASE COUNT          116 a           83 c           79 g           81 t
ORIGIN      
        1 cttaagggcc acgaggtctt ggaaaacaca gctcgctacg ctaaaatctt gctcaaacat
       61 gaattgaccg tgcctgtcag tgcagatgaa aagctagaag aagagcaaaa aggtatcatc
      121 gagttcatga agcgtgaagc tggacggtca gaagaattga caaacattcc tctggaaact
      181 gagttgactg tctttgttga caatccacaa atccgcttca agactcgctt tactaacact
      241 gccaaggatc accgtatccg tctcttggtc aagactcata acacgcgtcc aagcaatgat
      301 tctgaaagta tctatgaggt ggtgacacga ccaaacaaac cagctgcttc atgggaaaa
//
LOCUS       DBMVGT010000284          359 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.288, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000284 DBMVGT010000000
VERSION     DBMVGT010000284.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 359)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 359)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.288"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>359
                     /locus_tag="AC0DU4_002356"
     CDS             <1..>359
                     /locus_tag="AC0DU4_002356"
                     /EC_number="3.4.11.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0004177 - aminopeptidase activity
                     [Evidence IEA];
                     GO_process: GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HIN4238231.1"
                     /translation="WAKKVFPNAASDEEAVDLLWDQIFKTCRVYEADPVKAWEEHAAI
                     LKSKADMLNKEQFSALHYTAPGTDLTLGLPKNHVWESAGAVNAQGEGFLPNMPTEEVF
                     TAPDFRRADGYVTSTKPL"
BASE COUNT          101 a           89 c           87 g           82 t
ORIGIN      
        1 tgggctaaga aagtcttccc aaatgctgcg agcgacgaag aagcagtcga tctcctttgg
       61 gaccaaatct tcaaaacttg ccgtgtctac gaagcagatc ctgttaaggc ctgggaagag
      121 catgcagcca ttctcaagag caaggccgat atgcttaata aggagcaatt ttcagccctt
      181 cactacacag cgccaggaac agatttaaca cttggtttgc caaagaacca cgtttgggaa
      241 tcagctggtg ctgtcaatgc acagggcgaa ggattcttgc caaatatgcc gacagaagag
      301 gtcttcacag cgcctgactt ccgtcgtgca gatggttatg tcacttctac aaaaccgct
//
LOCUS       DBMVGT010000285          357 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.289, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000285 DBMVGT010000000
VERSION     DBMVGT010000285.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 357)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 357)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.289"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>357
                     /locus_tag="AC0DU4_002357"
     CDS             <1..>357
                     /locus_tag="AC0DU4_002357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HIN4238232.1"
                     /translation="TLDLLIIGGGITGAGVALQAAASGLETGLIEMQDFAEGTSSRST
                     KLVHGGLRYLKQFDVEVVSDTVSERAVVQQIAPHIPKSDPMLLPVYDEDGATFSLFRL
                     KVAMDLYDLLAGVSNTS"
BASE COUNT           97 a           80 c           86 g           94 t
ORIGIN      
        1 accctggacc tcttgattat cggtggagga atcacaggag ctggtgtagc cttgcaggcg
       61 gcagctagcg gtcttgagac tggtttgatt gaaatgcaag actttgcaga aggaacatct
      121 agtcgttcaa caaaattggt tcacggagga cttcgttacc tcaaacaatt tgacgtagaa
      181 gtggtctcag atacggtttc tgaacgtgca gtggttcaac aaatcgctcc acacattcca
      241 aaatcagatc caatgctctt accagtttac gatgaagatg gagcaacctt tagcctcttc
      301 cgtcttaaag tagccatgga cttgtacgac cttttagcag gtgtgagcaa cacgtca
//
LOCUS       DBMVGT010000286          357 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.290, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000286 DBMVGT010000000
VERSION     DBMVGT010000286.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 357)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 357)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.290"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(1..357)
                     /locus_tag="AC0DU4_002358"
                     /pseudo
     CDS             complement(1..357)
                     /locus_tag="AC0DU4_002358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518194.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
BASE COUNT          128 a           69 c           60 g          100 t
ORIGIN      
        1 cagggattaa tagatctaaa gaaatcattt gtcaaagcaa gtggataagt acctgcactt
       61 gatgctaact atagtaaaag caaaataagt gagaaaaaag ctcctatacg gctattccac
      121 gttgctaaag tggtcaccat agacatgaat actaaacttg tttggatgat gagaataaat
      181 attctcatct catgattagc agttaaacca atagaactcc tccatatacc aaaattcctg
      241 ccaaaacagc tataatacca tttatttcag ctcgagattt caaccaaggc caacggctct
      301 ctggatgacg tcctgaaggc aatttcgcaa atattatatt tgttgatatt gctgcaa
//
LOCUS       DBMVGT010000287          327 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.291, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000287 DBMVGT010000000
VERSION     DBMVGT010000287.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 327)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.291"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>327
                     /locus_tag="AC0DU4_002359"
     CDS             <1..>327
                     /locus_tag="AC0DU4_002359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000966215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4238233.1"
                     /translation="LRFNLEGATSGTAWVTGIKVEIGSVATDWSPAPEDADGLITEAK
                     ATFERTAQGLRTDLSAITEGLRTKVDISALNVTAENIRQSVKSLETDTQNKLNQKLSQ
                     AEFEVRA"
BASE COUNT           95 a           67 c           92 g           73 t
ORIGIN      
        1 attgcgattc aatcttgaag gtgctacaag cggtacagct tgggtaacag gaatcaaggt
       61 tgaaatcggt agtgtggcga cggactggag tcctgcgcct gaggacgctg atggtctcat
      121 tactgaagct aaggctacct ttgagcggac agctcagggc ttgcgaaccg acttatcagc
      181 tattactgaa gggcttagaa ccaaagtgga tatcagcgca ctcaacgtga ctgctgaaaa
      241 tatccggcaa tctgtaaaga gtcttgagac agacacgcag aacaaactaa atcagaagtt
      301 gagtcaggct gaatttgagg tgcgagc
//
LOCUS       DBMVGT010000288          317 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.292, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000288 DBMVGT010000000
VERSION     DBMVGT010000288.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 317)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 317)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.292"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>317
                     /locus_tag="AC0DU4_002360"
     rRNA            <1..>317
                     /locus_tag="AC0DU4_002360"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
BASE COUNT           97 a           60 c           87 g           73 t
ORIGIN      
        1 ggacaacagg ttgatattcc tgtactagag tatgtagtga tggagggacg cagtaggcta
       61 actaaagcag acgattggaa gagtctgtct aagcagtgag gtgtgaattg agtcaaatgc
      121 ttaattctat aacattgagc tgtgatgggg agcgaagttt agtagcgaag ttagtgacgt
      181 cacactgcca agaaaagctt ctagcgttta aacatactct acccgtaccg caaaccgaca
      241 caggtagtcg aggcgagtag cctcaggtga gcgagagaac tctcgttaag gaactcggca
      301 aaatgacccc gtaactt
//
LOCUS       DBMVGT010000289          315 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.293, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000289 DBMVGT010000000
VERSION     DBMVGT010000289.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 315)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 315)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.293"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>315
                     /locus_tag="AC0DU4_002361"
     CDS             <1..>315
                     /locus_tag="AC0DU4_002361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComB"
                     /protein_id="HIN4238234.1"
                     /translation="QSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYASQL
                     DMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETIA
                     SQN"
BASE COUNT          104 a           65 c           80 g           66 t
ORIGIN      
        1 cagtcaacta gcaacaatcg tattcttgtc aatcatttgg aagaaaataa gctggttaag
       61 aagggggatc ttttggttca ataccaagaa ggggcagagg gtgtccaagc ggagtcctat
      121 gccagtcagt tggacatgct aaaggatcaa aaaaagcaat tggagtatct gcaaaagagc
      181 ctgcaagaag gggagaacca ctttccagag gaggataagt ttggctacca agccaccttt
      241 cgcgactaca tcagtcaagc aggcagtctt agggctagta catcgcaaca aaatgagacc
      301 atcgcgtccc agaat
//
LOCUS       DBMVGT010000290          308 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.294, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000290 DBMVGT010000000
VERSION     DBMVGT010000290.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 308)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 308)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.294"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>308
                     /locus_tag="AC0DU4_002362"
     CDS             <1..>308
                     /locus_tag="AC0DU4_002362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0017150 - tRNA dihydrouridine synthase
                     activity [Evidence IEA];
                     GO_function: GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA];
                     GO_process: GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA-dihydrouridine synthase"
                     /protein_id="HIN4238235.1"
                     /translation="AMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEA
                     KQRIEEVGADAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLI
                     "
BASE COUNT           95 a           81 c           63 g           69 t
ORIGIN      
        1 gccatgcatg gccgtacccg tgaacaaatg tatactggcc acgcagacct tgagaccctt
       61 tacaaggttg cccaagctct aaccaagatt ccattcatcg ccaacggtga tatccgtact
      121 gtccaagaag ccaagcaacg catcgaagaa gttggtgctg acgcagtcat gattggccga
      181 gctgccatgg gaaatcctta cctcttcaac caaatcaacc attactttga aacaggagaa
      241 atcctacctg atttgacctt tgaagacaag atgaagatcg cctacgaaca cttgaaacga
      301 ttgattaa
//
LOCUS       DBMVGT010000291          307 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.295, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000291 DBMVGT010000000
VERSION     DBMVGT010000291.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 307)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 307)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.295"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            146..>307
                     /locus_tag="AC0DU4_002363"
     rRNA            146..>307
                     /locus_tag="AC0DU4_002363"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          104 a           55 c           84 g           64 t
ORIGIN      
        1 tcgcttgaga gaagcaagtg acaaagacct ttgaaaactg aacaagacga accaatgtgc
       61 agggcgctac aacataagtt gtagtactga acaatgaaaa aaacaataaa tctgtcagtg
      121 acagaaatga gtaagaactc aaacttttaa tgagagtttg atcctggctc aggacgaacg
      181 ctggcggcgt gcctaataca tgcaagtaga acgctgaagg aggagcttgc ttctctggat
      241 gagttgcgaa cgggtgagta acgcgtaggt aacctgcctg gtagcggggg ataactattg
      301 gaaacga
//
LOCUS       DBMVGT010000292          306 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.296, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000292 DBMVGT010000000
VERSION     DBMVGT010000292.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 306)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 306)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.296"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..82)
                     /gene="ffs"
                     /locus_tag="AC0DU4_002364"
     ncRNA           complement(<1..82)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="AC0DU4_002364"
                     /product="signal recognition particle sRNA small type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:15.0:RF00169"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00169"
     gene            complement(115..>306)
                     /locus_tag="AC0DU4_002365"
     CDS             complement(115..>306)
                     /locus_tag="AC0DU4_002365"
                     /EC_number="3.5.4.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology.
                     GO_function: GO:0008270 - zinc ion binding [Evidence IEA];
                     GO_function: GO:0019239 - deaminase activity [Evidence
                     IEA];
                     GO_process: GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HIN4238236.1"
                     /translation="AIGLARIPNVVYGAKNQKFGAAGSLYNILTDERLNHRVEVEIGI
                     LEDECAAIMQDFFRNRRKK"
BASE COUNT           85 a           84 c           45 g           92 t
ORIGIN      
        1 gagcacacaa ttcaaatcgc ttagggctgc tggattcctc ccctgacccg cttcacgcag
       61 aactgttgct ccactattta ttatatcaca ttcctattca ttttaaaagc aaaattattt
      121 tttccgtcta tttctaaaaa aatcctgcat gatagctgcg cattcatctt ccaaaattcc
      181 tatttcaacc tccacacgat gattgagacg ctcatctgtc aagatattgt acaaactccc
      241 agcagcgcca aatttctggt ttttagcccc atagaccaca tttggaatgc gggcaagccc
      301 aatcgc
//
LOCUS       DBMVGT010000293          298 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.297, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000293 DBMVGT010000000
VERSION     DBMVGT010000293.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 298)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.297"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>298)
                     /locus_tag="AC0DU4_002366"
     CDS             complement(<1..>298)
                     /locus_tag="AC0DU4_002366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HIN4238237.1"
                     /translation="EFFLQFHQLNQLIVDIDSTHFTTYGKQEGVAYNAHYRAHGYHPL
                     YAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFRMDSGFATPKLYD"
BASE COUNT           99 a           55 c           67 g           77 t
ORIGIN      
        1 aatcgtataa ttttggggtc gcaaagccac tatccattcg aaagagaagt tgattaaacc
       61 gttctaaaac aggtgtgata aagctgtctg cctcttcaga acaataacga ttaccaggac
      121 gaagctgggc attgaaacaa taacctgtct tcccctcgaa agcataaaga ggatgatagc
      181 catgagcacg atagtgggcg ttataagcaa caccttcttg cttgccataa gttgtgaaat
      241 gggtagaatc gatatctaca atgagttggt ttagctggtg aaactgtaaa aagaattc
//
LOCUS       DBMVGT010000294          295 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.298, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000294 DBMVGT010000000
VERSION     DBMVGT010000294.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 295)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 295)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.298"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            124..>295
                     /locus_tag="AC0DU4_002367"
     CDS             124..>295
                     /locus_tag="AC0DU4_002367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000603347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="HIN4238238.1"
                     /translation="MLRHPGISPTNDLIAKKIFSNPEITCQFIRDMLDLPAKNVTILE
                     GSDIHVLLSMPYS"
BASE COUNT           98 a           56 c           48 g           93 t
ORIGIN      
        1 ataatatatt gaatctataa tagtacacct tgactgctaa aatatttcta taaattaatt
       61 tgactttcct gatagagtta ttcacatctt atttcaactc actatagaag gaggaatagg
      121 aggattctca gacatccggg catcagccca actaatgatt tgattgctaa gaaaatattc
      181 agcaatccag aaatcacttg tcaatttatt cgcgatatgc tggacttgcc agcaaaaaat
      241 gtgaccattt tggagggaag cgatattcac gtattactct ccatgcctta ctcag
//
LOCUS       DBMVGT010000295          278 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.299, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000295 DBMVGT010000000
VERSION     DBMVGT010000295.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 278)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 278)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.299"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>278
                     /locus_tag="AC0DU4_002368"
     CDS             <1..>278
                     /locus_tag="AC0DU4_002368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001821980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HIN4238239.1"
                     /translation="LNATKDKADKTLVVSEAGKLREEFSKMKVGGRNLWIKSKTVGAV
                     IEKLPENHVTGQKECYRLENNSTLTFNLEPDFSSRLYQKVTFSAWIKY"
BASE COUNT          101 a           46 c           62 g           69 t
ORIGIN      
        1 ctgaacgcaa ccaaggataa agcagataag actttagttg tatctgaagc cgggaaattg
       61 cgtgaagaat tttcaaaaat gaaggtggga ggccggaatc tatggataaa atccaagacg
      121 gttggagctg taattgaaaa attacctgaa aaccacgtca caggtcaaaa agaatgttat
      181 aggttagaga acaactctac tttaacgttc aaccttgaac cagatttcag ctcaaggttg
      241 tatcaaaaag ttacttttag cgcttggatc aagtacga
//
LOCUS       DBMVGT010000296          266 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.300, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000296 DBMVGT010000000
VERSION     DBMVGT010000296.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 266)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 266)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.300"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            complement(<1..>266)
                     /locus_tag="AC0DU4_002369"
     CDS             complement(<1..>266)
                     /locus_tag="AC0DU4_002369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HIN4238240.1"
                     /translation="KEILSNPNYGNAGKFAEVWMDGARGEGVQKVNYEFEKWFETIRD
                     LQGACLIFSTEGTSIRWIGNERGYAGDPLWQKVNPDKLGTEAEL"
BASE COUNT           66 a           78 c           42 g           80 t
ORIGIN      
        1 cagctctgct tctgttccta gtttatcagg attcaccttt tgccacagtg gatcacctgc
       61 ataccctcgt tcattgccaa tccagcggat actggtgcct tctgttgaaa aaatcaagca
      121 agcgccctgc aggtcacgaa tggtttcaaa ccatttttca aattcataat taaccttttg
      181 cacgccctct cctctggcac catccatcca aacctcagcg aacttaccag cattcccata
      241 gttaggattt gataagattt ccttca
//
LOCUS       DBMVGT010000297          265 bp    DNA     linear   BCT 02-MAR-2026
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 23GB001438
            SAMEA120841144-rid29148973.denovo.301, whole genome shotgun
            sequence.
ACCESSION   DBMVGT010000297 DBMVGT010000000
VERSION     DBMVGT010000297.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMEA120841144
            Sequence Read Archive: ERR16049385
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 265)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 265)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2026) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using the SAUTE guided assembler with
            antimicrobial resistance genes and Stx operons as baits to increase
            sensitivity and specificity for those genes. Note, contigs derived
            from the SAUTE guided assembly may overlap de-novo contigs from
            SKESA, and/or other SAUTE contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names, which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 28-FEB-2026
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT003120308.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT003120308.1
            Genome Coverage       :: 356x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 03/01/2026 02:19:38
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Annotation Software revision      :: 2025-05-06.build7983
            Genes (total)                     :: 2,370
            CDSs (total)                      :: 2,335
            Genes (coding)                    :: 2,187
            CDSs (with protein)               :: 2,187
            Genes (RNA)                       :: 35
            rRNAs                             :: 3, 4 (16S, 23S)
            partial rRNAs                     :: 3, 4 (16S, 23S)
            tRNAs                             :: 25
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 73 of 148
            Pseudo Genes (incomplete)         :: 75 of 148
            Pseudo Genes (internal stop)      :: 45 of 148
            Pseudo Genes (multiple problems)  :: 38 of 148
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMEA120841144-rid29148973.denovo.301"
                     /isolate="23GB001438"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /geo_loc_name="Norway"
                     /collection_date="2023-06-24"
     gene            <1..>265
                     /locus_tag="AC0DU4_002370"
     CDS             <1..>265
                     /locus_tag="AC0DU4_002370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187211.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HIN4238241.1"
                     /translation="IVEAIESALEKVDEYAESYNRLEQLDKEFPDKLKKSILQYAMQG
                     KLVEQDPNDESVEVLLEKIRAEKQKLFEEGKIKKKDLDISIVSQ"
BASE COUNT          119 a           34 c           45 g           67 t
ORIGIN      
        1 atagtagaag caatcgaatc agctttagaa aaagtagatg aatatgctga aagttataat
       61 agactagaac agctagataa agaatttcca gataaactaa aaaaatctat tcttcaatat
      121 gctatgcaag gaaaattagt tgaacaagac ccaaatgatg aatcagtcga agttttactt
      181 gaaaaaatac gagcagaaaa acaaaaactc tttgaagaag gcaagattaa aaagaaagat
      241 ttggacattt ctattgtttc ccaag
//
