data_PRD_000200
# 
_pdbx_reference_molecule.prd_id                       PRD_000200 
_pdbx_reference_molecule.name                         "Nisin A" 
_pdbx_reference_molecule.represent_as                 polymer 
_pdbx_reference_molecule.type                         Polypeptide 
_pdbx_reference_molecule.type_evidence_code           ? 
_pdbx_reference_molecule.class                        Lantibiotic 
_pdbx_reference_molecule.class_evidence_code          ? 
_pdbx_reference_molecule.formula                      "C141 H233 N41 O38 S7" 
_pdbx_reference_molecule.formula_weight               3335.066 
_pdbx_reference_molecule.chem_comp_id                 ? 
_pdbx_reference_molecule.release_status               REL 
_pdbx_reference_molecule.replaces                     ? 
_pdbx_reference_molecule.replaced_by                  ? 
_pdbx_reference_molecule.compound_details             
;NISIN Z IS A LINEAR TYPE A LANTIBIOTIC, A CLASS OF ANTIBIOTICS
CHARACTERIZED BY THIOETHER AMINO ACIDS LANTHIONINE AND/OR
METHYLLANTHIONINE.
HERE, NISIN Z IS REPRESENTED BY THE SEQUENCE (SEQRES)
;
_pdbx_reference_molecule.description                  
;Nisin Z is a heptacyclic peptide. Post Translational maturation of
lantibiotics involves the enzymic conversion of Thr, and Ser into
dehydrated AA and the formation of thioether bonds with cysteine.
Thioether bonds with cysteine result in five cyclic structures along
the peptide chain.  This is followed by membrane translocation and
cleavage of the modified precursor.
;
_pdbx_reference_molecule.representative_PDB_id_code   1wco 
# 
_pdbx_reference_entity_list.prd_id          PRD_000200 
_pdbx_reference_entity_list.ref_entity_id   1 
_pdbx_reference_entity_list.component_id    1 
_pdbx_reference_entity_list.type            polymer 
_pdbx_reference_entity_list.details         "PEPTIDE LIKE SEQUENCE RESIDUES 1 TO 34" 
# 
loop_
_pdbx_reference_entity_poly_link.prd_id 
_pdbx_reference_entity_poly_link.ref_entity_id 
_pdbx_reference_entity_poly_link.link_id 
_pdbx_reference_entity_poly_link.atom_id_1 
_pdbx_reference_entity_poly_link.comp_id_1 
_pdbx_reference_entity_poly_link.entity_seq_num_1 
_pdbx_reference_entity_poly_link.atom_id_2 
_pdbx_reference_entity_poly_link.comp_id_2 
_pdbx_reference_entity_poly_link.entity_seq_num_2 
_pdbx_reference_entity_poly_link.value_order 
_pdbx_reference_entity_poly_link.component_id 
_pdbx_reference_entity_poly_link.details 
_pdbx_reference_entity_poly_link.insert_code_1 
_pdbx_reference_entity_poly_link.insert_code_2 
PRD_000200 1 1  C  ILE 1  N  DBU 2  sing 1 ? ? ? 
PRD_000200 1 2  C  DBU 2  N  DAL 3  sing 1 ? ? ? 
PRD_000200 1 3  CB DAL 3  SG CYS 7  sing 1 ? ? ? 
PRD_000200 1 4  C  DAL 3  N  ILE 4  sing 1 ? ? ? 
PRD_000200 1 5  C  ILE 4  N  DHA 5  sing 1 ? ? ? 
PRD_000200 1 6  C  DHA 5  N  LEU 6  sing 1 ? ? ? 
PRD_000200 1 7  C  LEU 6  N  CYS 7  sing 1 ? ? ? 
PRD_000200 1 8  C  CYS 7  N  DBB 8  sing 1 ? ? ? 
PRD_000200 1 9  CB DBB 8  SG CYS 11 sing 1 ? ? ? 
PRD_000200 1 10 C  DBB 8  N  PRO 9  sing 1 ? ? ? 
PRD_000200 1 11 C  PRO 9  N  GLY 10 sing 1 ? ? ? 
PRD_000200 1 12 C  GLY 10 N  CYS 11 sing 1 ? ? ? 
PRD_000200 1 13 C  CYS 11 N  LYS 12 sing 1 ? ? ? 
PRD_000200 1 14 C  LYS 12 N  DBB 13 sing 1 ? ? ? 
PRD_000200 1 15 CB DBB 13 SG CYS 19 sing 1 ? ? ? 
PRD_000200 1 16 C  DBB 13 N  GLY 14 sing 1 ? ? ? 
PRD_000200 1 17 C  GLY 14 N  ALA 15 sing 1 ? ? ? 
PRD_000200 1 18 C  ALA 15 N  LEU 16 sing 1 ? ? ? 
PRD_000200 1 19 C  LEU 16 N  MET 17 sing 1 ? ? ? 
PRD_000200 1 20 C  MET 17 N  GLY 18 sing 1 ? ? ? 
PRD_000200 1 21 C  GLY 18 N  CYS 19 sing 1 ? ? ? 
PRD_000200 1 22 C  CYS 19 N  ASN 20 sing 1 ? ? ? 
PRD_000200 1 23 C  ASN 20 N  MET 21 sing 1 ? ? ? 
PRD_000200 1 24 C  MET 21 N  LYS 22 sing 1 ? ? ? 
PRD_000200 1 25 C  LYS 22 N  DBB 23 sing 1 ? ? ? 
PRD_000200 1 26 CB DBB 23 SG CYS 26 sing 1 ? ? ? 
PRD_000200 1 27 C  DBB 23 N  ALA 24 sing 1 ? ? ? 
PRD_000200 1 28 C  ALA 24 N  DBB 25 sing 1 ? ? ? 
PRD_000200 1 29 CB DBB 25 SG CYS 28 sing 1 ? ? ? 
PRD_000200 1 30 C  DBB 25 N  CYS 26 sing 1 ? ? ? 
PRD_000200 1 31 C  CYS 26 N  ASN 27 sing 1 ? ? ? 
PRD_000200 1 32 C  ASN 27 N  CYS 28 sing 1 ? ? ? 
PRD_000200 1 33 C  CYS 28 N  SER 29 sing 1 ? ? ? 
PRD_000200 1 34 C  SER 29 N  ILE 30 sing 1 ? ? ? 
PRD_000200 1 35 C  ILE 30 N  HIS 31 sing 1 ? ? ? 
PRD_000200 1 36 C  HIS 31 N  VAL 32 sing 1 ? ? ? 
PRD_000200 1 37 C  VAL 32 N  DHA 33 sing 1 ? ? ? 
PRD_000200 1 38 C  DHA 33 N  LYS 34 sing 1 ? ? ? 
# 
_pdbx_reference_entity_poly.prd_id          PRD_000200 
_pdbx_reference_entity_poly.ref_entity_id   1 
_pdbx_reference_entity_poly.db_code         P29559 
_pdbx_reference_entity_poly.db_name         UNP 
_pdbx_reference_entity_poly.type            peptide-like 
# 
_pdbx_reference_entity_sequence.prd_id          PRD_000200 
_pdbx_reference_entity_sequence.ref_entity_id   1 
_pdbx_reference_entity_sequence.type            peptide-like 
_pdbx_reference_entity_sequence.NRP_flag        N 
# 
loop_
_pdbx_reference_entity_poly_seq.prd_id 
_pdbx_reference_entity_poly_seq.ref_entity_id 
_pdbx_reference_entity_poly_seq.num 
_pdbx_reference_entity_poly_seq.mon_id 
_pdbx_reference_entity_poly_seq.parent_mon_id 
_pdbx_reference_entity_poly_seq.hetero 
_pdbx_reference_entity_poly_seq.observed 
PRD_000200 1 1  ILE ILE N Y 
PRD_000200 1 2  DBU THR N Y 
PRD_000200 1 3  DAL SER N Y 
PRD_000200 1 4  ILE ILE N Y 
PRD_000200 1 5  DHA SER N Y 
PRD_000200 1 6  LEU LEU N Y 
PRD_000200 1 7  CYS CYS N Y 
PRD_000200 1 8  DBB THR N Y 
PRD_000200 1 9  PRO PRO N Y 
PRD_000200 1 10 GLY GLY N Y 
PRD_000200 1 11 CYS CYS N Y 
PRD_000200 1 12 LYS LYS N Y 
PRD_000200 1 13 DBB THR N Y 
PRD_000200 1 14 GLY GLY N Y 
PRD_000200 1 15 ALA ALA N Y 
PRD_000200 1 16 LEU LEU N Y 
PRD_000200 1 17 MET MET N Y 
PRD_000200 1 18 GLY GLY N Y 
PRD_000200 1 19 CYS CYS N Y 
PRD_000200 1 20 ASN ASN N Y 
PRD_000200 1 21 MET MET N Y 
PRD_000200 1 22 LYS LYS N Y 
PRD_000200 1 23 DBB THR N Y 
PRD_000200 1 24 ALA ALA N Y 
PRD_000200 1 25 DBB THR N Y 
PRD_000200 1 26 CYS CYS N Y 
PRD_000200 1 27 ASN ASN N Y 
PRD_000200 1 28 CYS CYS N Y 
PRD_000200 1 29 SER SER N Y 
PRD_000200 1 30 ILE ILE N Y 
PRD_000200 1 31 HIS HIS N Y 
PRD_000200 1 32 VAL VAL N Y 
PRD_000200 1 33 DHA SER N Y 
PRD_000200 1 34 LYS LYS N Y 
# 
_pdbx_reference_entity_src_nat.prd_id                PRD_000200 
_pdbx_reference_entity_src_nat.ref_entity_id         1 
_pdbx_reference_entity_src_nat.ordinal               1 
_pdbx_reference_entity_src_nat.taxid                 1360 
_pdbx_reference_entity_src_nat.organism_scientific   "Lactococcus lactis NIZO 22186" 
_pdbx_reference_entity_src_nat.source                UniProt 
_pdbx_reference_entity_src_nat.db_code               P13068 
_pdbx_reference_entity_src_nat.db_name               UniProtKB 
_pdbx_reference_entity_src_nat.strain                ? 
# 
loop_
_pdbx_prd_audit.prd_id 
_pdbx_prd_audit.date 
_pdbx_prd_audit.processing_site 
_pdbx_prd_audit.action_type 
PRD_000200 2012-02-03 RCSB "Create molecule"    
PRD_000200 2012-07-09 PDBE "Other modification" 
PRD_000200 2012-12-12 RCSB "Initial release"    
PRD_000200 2013-06-03 RCSB "Other modification" 
PRD_000200 2017-05-04 RCSB "Other modification" 
PRD_000200 2023-09-20 PDBE "Modify audit"       
# 
