data_PRD_000222
# 
_pdbx_reference_molecule.prd_id                       PRD_000222 
_pdbx_reference_molecule.name                         "RAMOPLANIN A2" 
_pdbx_reference_molecule.represent_as                 polymer 
_pdbx_reference_molecule.type                         Lipoglycopeptide 
_pdbx_reference_molecule.type_evidence_code           ? 
_pdbx_reference_molecule.class                        Antibiotic 
_pdbx_reference_molecule.class_evidence_code          ? 
_pdbx_reference_molecule.formula                      "C119 H154 Cl N21 O40" 
_pdbx_reference_molecule.formula_weight               2554.066 
_pdbx_reference_molecule.chem_comp_id                 ? 
_pdbx_reference_molecule.release_status               REL 
_pdbx_reference_molecule.replaces                     ? 
_pdbx_reference_molecule.replaced_by                  ? 
_pdbx_reference_molecule.compound_details             
;RAMOPLANIN IS A CYCLIC LIPOGLYCOPEPTIDE.
HERE, RAMOPLANIN IS REPRESENTED BY GROUPING TOGETHER THE
SEQUENCE (SEQRES) A FATTY ACID (FA7) AND TWO LIGANDS (HET) MAN.
;
_pdbx_reference_molecule.description                  
;RAMOPLANIN A2 IS A CYCLIC HEPTADECAMER
LIPOGLYCODEPSIPEPTIDE.
THE SCAFFOLD IS A HEPTA CYCLIC PEPTIDE
GLYCOSYLATED BY ONE DISACCHARIDE AND A FATTY ACID
AT THE N-TERM.
;
_pdbx_reference_molecule.representative_PDB_id_code   1dsr 
# 
loop_
_pdbx_reference_entity_list.prd_id 
_pdbx_reference_entity_list.ref_entity_id 
_pdbx_reference_entity_list.component_id 
_pdbx_reference_entity_list.type 
_pdbx_reference_entity_list.details 
PRD_000222 1 1 polymer     "PEPTIDE LIKE SEQUENCE RESIDUES 1 TO 17" 
PRD_000222 2 2 non-polymer "SUGAR RESIDUES MAN"                     
PRD_000222 2 3 non-polymer "SUGAR RESIDUES MAN"                     
PRD_000222 3 4 non-polymer "FATTY ACID RESIDUE FA7"                 
# 
loop_
_pdbx_reference_entity_nonpoly.prd_id 
_pdbx_reference_entity_nonpoly.ref_entity_id 
_pdbx_reference_entity_nonpoly.name 
_pdbx_reference_entity_nonpoly.chem_comp_id 
_pdbx_reference_entity_nonpoly.details 
PRD_000222 2 ALPHA-D-MANNOSE                         MAN ? 
PRD_000222 3 "(2Z,4E)-7-methylocta-2,4-dienoic acid" FA7 ? 
# 
loop_
_pdbx_reference_entity_link.prd_id 
_pdbx_reference_entity_link.link_id 
_pdbx_reference_entity_link.link_class 
_pdbx_reference_entity_link.ref_entity_id_1 
_pdbx_reference_entity_link.entity_seq_num_1 
_pdbx_reference_entity_link.comp_id_1 
_pdbx_reference_entity_link.atom_id_1 
_pdbx_reference_entity_link.ref_entity_id_2 
_pdbx_reference_entity_link.entity_seq_num_2 
_pdbx_reference_entity_link.comp_id_2 
_pdbx_reference_entity_link.atom_id_2 
_pdbx_reference_entity_link.value_order 
_pdbx_reference_entity_link.component_1 
_pdbx_reference_entity_link.component_2 
_pdbx_reference_entity_link.details 
_pdbx_reference_entity_link.nonpoly_res_num_1 
_pdbx_reference_entity_link.nonpoly_res_num_2 
PRD_000222 1 PN 1 1  ASN N  3 ? FA7 C1 sing 1 4 ? ? ? 
PRD_000222 2 PN 1 11 D4P O4 2 ? MAN C1 sing 1 2 ? ? ? 
PRD_000222 3 NN 2 ?  MAN O2 2 ? MAN C1 sing 2 3 ? ? ? 
# 
loop_
_pdbx_reference_entity_poly_link.prd_id 
_pdbx_reference_entity_poly_link.ref_entity_id 
_pdbx_reference_entity_poly_link.link_id 
_pdbx_reference_entity_poly_link.atom_id_1 
_pdbx_reference_entity_poly_link.comp_id_1 
_pdbx_reference_entity_poly_link.entity_seq_num_1 
_pdbx_reference_entity_poly_link.atom_id_2 
_pdbx_reference_entity_poly_link.comp_id_2 
_pdbx_reference_entity_poly_link.entity_seq_num_2 
_pdbx_reference_entity_poly_link.value_order 
_pdbx_reference_entity_poly_link.component_id 
_pdbx_reference_entity_poly_link.details 
_pdbx_reference_entity_poly_link.insert_code_1 
_pdbx_reference_entity_poly_link.insert_code_2 
PRD_000222 1 1  C  ASN 1  N AHB 2  sing 1 ? ? ? 
PRD_000222 1 2  OB AHB 2  C CHP 17 sing 1 ? ? ? 
PRD_000222 1 3  C  AHB 2  N GHP 3  sing 1 ? ? ? 
PRD_000222 1 4  C  GHP 3  N ORD 4  sing 1 ? ? ? 
PRD_000222 1 5  C  ORD 4  N 2TL 5  sing 1 ? ? ? 
PRD_000222 1 6  C  2TL 5  N D4P 6  sing 1 ? ? ? 
PRD_000222 1 7  C  D4P 6  N GHP 7  sing 1 ? ? ? 
PRD_000222 1 8  C  GHP 7  N ALO 8  sing 1 ? ? ? 
PRD_000222 1 9  C  ALO 8  N PHE 9  sing 1 ? ? ? 
PRD_000222 1 10 C  PHE 9  N ORD 10 sing 1 ? ? ? 
PRD_000222 1 11 C  ORD 10 N D4P 11 sing 1 ? ? ? 
PRD_000222 1 12 C  D4P 11 N 2TL 12 sing 1 ? ? ? 
PRD_000222 1 13 C  2TL 12 N D4P 13 sing 1 ? ? ? 
PRD_000222 1 14 C  D4P 13 N GLY 14 sing 1 ? ? ? 
PRD_000222 1 15 C  GLY 14 N LEU 15 sing 1 ? ? ? 
PRD_000222 1 16 C  LEU 15 N DAL 16 sing 1 ? ? ? 
PRD_000222 1 17 C  DAL 16 N CHP 17 sing 1 ? ? ? 
# 
_pdbx_reference_entity_poly.prd_id          PRD_000222 
_pdbx_reference_entity_poly.ref_entity_id   1 
_pdbx_reference_entity_poly.db_code         NOR00844 
_pdbx_reference_entity_poly.db_name         NOR 
_pdbx_reference_entity_poly.type            peptide-like 
# 
_pdbx_reference_entity_sequence.prd_id          PRD_000222 
_pdbx_reference_entity_sequence.ref_entity_id   1 
_pdbx_reference_entity_sequence.type            peptide-like 
_pdbx_reference_entity_sequence.NRP_flag        Y 
# 
loop_
_pdbx_reference_entity_poly_seq.prd_id 
_pdbx_reference_entity_poly_seq.ref_entity_id 
_pdbx_reference_entity_poly_seq.num 
_pdbx_reference_entity_poly_seq.mon_id 
_pdbx_reference_entity_poly_seq.parent_mon_id 
_pdbx_reference_entity_poly_seq.hetero 
_pdbx_reference_entity_poly_seq.observed 
PRD_000222 1 1  ASN ASN N Y 
PRD_000222 1 2  AHB ASN N Y 
PRD_000222 1 3  GHP GLY N Y 
PRD_000222 1 4  ORD ARG N Y 
PRD_000222 1 5  2TL THR N Y 
PRD_000222 1 6  D4P GLY N Y 
PRD_000222 1 7  GHP GLY N Y 
PRD_000222 1 8  ALO THR N Y 
PRD_000222 1 9  PHE PHE N Y 
PRD_000222 1 10 ORD ARG N Y 
PRD_000222 1 11 D4P GLY N Y 
PRD_000222 1 12 2TL THR N Y 
PRD_000222 1 13 D4P GLY N Y 
PRD_000222 1 14 GLY GLY N Y 
PRD_000222 1 15 LEU LEU N Y 
PRD_000222 1 16 DAL ALA N Y 
PRD_000222 1 17 CHP GLY N Y 
# 
_pdbx_reference_entity_src_nat.prd_id                PRD_000222 
_pdbx_reference_entity_src_nat.ref_entity_id         1 
_pdbx_reference_entity_src_nat.ordinal               1 
_pdbx_reference_entity_src_nat.taxid                 1971 
_pdbx_reference_entity_src_nat.organism_scientific   "Actinoplanes strain ATCC 33076" 
_pdbx_reference_entity_src_nat.source                ? 
_pdbx_reference_entity_src_nat.db_code               NOR00844 
_pdbx_reference_entity_src_nat.db_name               Norine 
_pdbx_reference_entity_src_nat.strain                ? 
# 
loop_
_pdbx_prd_audit.prd_id 
_pdbx_prd_audit.date 
_pdbx_prd_audit.processing_site 
_pdbx_prd_audit.action_type 
PRD_000222 2012-02-03 RCSB "Create molecule"    
PRD_000222 2012-07-09 PDBE "Other modification" 
PRD_000222 2012-07-31 RCSB "Other modification" 
PRD_000222 2012-12-12 RCSB "Initial release"    
PRD_000222 2013-06-03 RCSB "Other modification" 
PRD_000222 2017-05-04 RCSB "Other modification" 
PRD_000222 2023-09-20 PDBE "Modify audit"       
# 
