data_PRD_002603
# 
_pdbx_reference_molecule.prd_id                       PRD_002603 
_pdbx_reference_molecule.name                         "manikomycin (MKM)" 
_pdbx_reference_molecule.represent_as                 polymer 
_pdbx_reference_molecule.type                         "Cyclic depsipeptide" 
_pdbx_reference_molecule.type_evidence_code           ? 
_pdbx_reference_molecule.class                        Antimicrobial 
_pdbx_reference_molecule.class_evidence_code          ? 
_pdbx_reference_molecule.formula                      "C50 H86 N22 O12" 
_pdbx_reference_molecule.formula_weight               1187.358 
_pdbx_reference_molecule.chem_comp_id                 ? 
_pdbx_reference_molecule.release_status               REL 
_pdbx_reference_molecule.replaces                     ? 
_pdbx_reference_molecule.replaced_by                  ? 
_pdbx_reference_molecule.compound_details             "It can kill multi-drug-resistant Enterobacteriaceae and is not susceptible to resistance associated with clinically used antibiotics. Manikomycin binds the E site of the bacterial ribosome, blocking tRNA exit and halting translation in a sequence-specific manner." 
_pdbx_reference_molecule.description                  "Cyclic depsipeptide" 
_pdbx_reference_molecule.representative_PDB_id_code   pdb_00009rja 
# 
_pdbx_reference_entity_list.prd_id          PRD_002603 
_pdbx_reference_entity_list.ref_entity_id   1 
_pdbx_reference_entity_list.component_id    1 
_pdbx_reference_entity_list.type            polymer 
_pdbx_reference_entity_list.details         . 
# 
loop_
_pdbx_reference_entity_poly_link.prd_id 
_pdbx_reference_entity_poly_link.ref_entity_id 
_pdbx_reference_entity_poly_link.link_id 
_pdbx_reference_entity_poly_link.atom_id_1 
_pdbx_reference_entity_poly_link.comp_id_1 
_pdbx_reference_entity_poly_link.entity_seq_num_1 
_pdbx_reference_entity_poly_link.atom_id_2 
_pdbx_reference_entity_poly_link.comp_id_2 
_pdbx_reference_entity_poly_link.entity_seq_num_2 
_pdbx_reference_entity_poly_link.value_order 
_pdbx_reference_entity_poly_link.component_id 
_pdbx_reference_entity_poly_link.details 
_pdbx_reference_entity_poly_link.insert_code_1 
_pdbx_reference_entity_poly_link.insert_code_2 
PRD_002603 1 1 C   DAR 1 N ORD 2 sing 1 . . . 
PRD_002603 1 2 C   ORD 2 N DPN 3 sing 1 . . . 
PRD_002603 1 3 C   DPN 3 N THR 4 sing 1 . . . 
PRD_002603 1 4 C   THR 4 N DSG 5 sing 1 . . . 
PRD_002603 1 5 OG1 THR 4 C HIS 9 sing 1 . . . 
PRD_002603 1 6 C   DSG 5 N DAR 6 sing 1 . . . 
PRD_002603 1 7 C   DAR 6 N DAR 7 sing 1 . . . 
PRD_002603 1 8 C   DAR 7 N THR 8 sing 1 . . . 
PRD_002603 1 9 C   THR 8 N HIS 9 sing 1 . . . 
# 
_pdbx_reference_entity_poly.prd_id          PRD_002603 
_pdbx_reference_entity_poly.ref_entity_id   1 
_pdbx_reference_entity_poly.db_code         . 
_pdbx_reference_entity_poly.db_name         . 
_pdbx_reference_entity_poly.type            peptide-like 
# 
_pdbx_reference_entity_sequence.prd_id          PRD_002603 
_pdbx_reference_entity_sequence.ref_entity_id   1 
_pdbx_reference_entity_sequence.type            peptide-like 
_pdbx_reference_entity_sequence.NRP_flag        N 
# 
loop_
_pdbx_reference_entity_poly_seq.prd_id 
_pdbx_reference_entity_poly_seq.ref_entity_id 
_pdbx_reference_entity_poly_seq.num 
_pdbx_reference_entity_poly_seq.mon_id 
_pdbx_reference_entity_poly_seq.parent_mon_id 
_pdbx_reference_entity_poly_seq.hetero 
_pdbx_reference_entity_poly_seq.observed 
PRD_002603 1 1 DAR .   N Y 
PRD_002603 1 2 ORD .   N Y 
PRD_002603 1 3 DPN .   N Y 
PRD_002603 1 4 THR THR N Y 
PRD_002603 1 5 DSG .   N Y 
PRD_002603 1 6 DAR .   N Y 
PRD_002603 1 7 DAR .   N Y 
PRD_002603 1 8 THR THR N Y 
PRD_002603 1 9 HIS HIS N Y 
# 
_pdbx_reference_entity_src_nat.prd_id                PRD_002603 
_pdbx_reference_entity_src_nat.ref_entity_id         1 
_pdbx_reference_entity_src_nat.ordinal               1 
_pdbx_reference_entity_src_nat.taxid                 1927 
_pdbx_reference_entity_src_nat.organism_scientific   "Streptomyces rimosus" 
_pdbx_reference_entity_src_nat.source                . 
_pdbx_reference_entity_src_nat.db_code               . 
_pdbx_reference_entity_src_nat.db_name               . 
_pdbx_reference_entity_src_nat.strain                . 
# 
loop_
_pdbx_prd_audit.prd_id 
_pdbx_prd_audit.date 
_pdbx_prd_audit.processing_site 
_pdbx_prd_audit.action_type 
PRD_002603 2026-05-21 PDBE "Create molecule" 
PRD_002603 2026-05-27 RCSB "Initial release" 
# 
