data_PRD_000487
# 
_pdbx_reference_molecule.prd_id                       PRD_000487 
_pdbx_reference_molecule.name                         Tsushimycin 
_pdbx_reference_molecule.represent_as                 polymer 
_pdbx_reference_molecule.type                         Lipopeptide 
_pdbx_reference_molecule.type_evidence_code           ? 
_pdbx_reference_molecule.class                        Antibiotic 
_pdbx_reference_molecule.class_evidence_code          ? 
_pdbx_reference_molecule.formula                      "C59 H93 N13 O20" 
_pdbx_reference_molecule.formula_weight               1304.65 
_pdbx_reference_molecule.chem_comp_id                 ? 
_pdbx_reference_molecule.release_status               REL 
_pdbx_reference_molecule.replaces                     ? 
_pdbx_reference_molecule.replaced_by                  ? 
_pdbx_reference_molecule.compound_details             
;TSUSHIMYCIN IS A CYCLIC DODEDECAMER LIPOPETIDE.
HERE, TSUSHIMYCIN IS REPRESENTED BY GROUPING TOGETHER THE SEQUENCE
(SEQRES) AND ONE LIGAND (HET) LNG.
;
_pdbx_reference_molecule.description                  
;TSUSHIMYCIN IS A CYCLIC LIPOPEPTIDE.
THE SCAFFOLD IS MADE OF TWO PARTS:
(1) ASP1 N-TERM EXOCYCLIC PART
(2) A DECAPEPTIDE RING. RESIDUE 2 AND 11 FORM
A PEPTIDE BOND.
A TETRADECENOIC FATTY ACID  IS LINKED TO THE
RESIDUE 1
;
_pdbx_reference_molecule.representative_PDB_id_code   1w3m 
# 
loop_
_pdbx_reference_entity_list.prd_id 
_pdbx_reference_entity_list.ref_entity_id 
_pdbx_reference_entity_list.component_id 
_pdbx_reference_entity_list.type 
_pdbx_reference_entity_list.details 
PRD_000487 1 1 polymer     "PEPTIDE LIKE SEQUENCE RESIDUES 1 TO 11" 
PRD_000487 2 2 non-polymer "FATTY ACID RESIDUE"                     
# 
_pdbx_reference_entity_nonpoly.prd_id          PRD_000487 
_pdbx_reference_entity_nonpoly.ref_entity_id   2 
_pdbx_reference_entity_nonpoly.name            "DELTA-3ISOTETRADECENOIC ACID" 
_pdbx_reference_entity_nonpoly.chem_comp_id    LNG 
_pdbx_reference_entity_nonpoly.details         ? 
# 
_pdbx_reference_entity_link.prd_id              PRD_000487 
_pdbx_reference_entity_link.link_id             1 
_pdbx_reference_entity_link.link_class          PN 
_pdbx_reference_entity_link.ref_entity_id_1     1 
_pdbx_reference_entity_link.entity_seq_num_1    1 
_pdbx_reference_entity_link.comp_id_1           ASP 
_pdbx_reference_entity_link.atom_id_1           N 
_pdbx_reference_entity_link.ref_entity_id_2     2 
_pdbx_reference_entity_link.entity_seq_num_2    ? 
_pdbx_reference_entity_link.comp_id_2           LNG 
_pdbx_reference_entity_link.atom_id_2           C1 
_pdbx_reference_entity_link.value_order         sing 
_pdbx_reference_entity_link.component_1         1 
_pdbx_reference_entity_link.component_2         2 
_pdbx_reference_entity_link.details             ? 
_pdbx_reference_entity_link.nonpoly_res_num_1   ? 
_pdbx_reference_entity_link.nonpoly_res_num_2   ? 
# 
loop_
_pdbx_reference_entity_poly_link.prd_id 
_pdbx_reference_entity_poly_link.ref_entity_id 
_pdbx_reference_entity_poly_link.link_id 
_pdbx_reference_entity_poly_link.atom_id_1 
_pdbx_reference_entity_poly_link.comp_id_1 
_pdbx_reference_entity_poly_link.entity_seq_num_1 
_pdbx_reference_entity_poly_link.atom_id_2 
_pdbx_reference_entity_poly_link.comp_id_2 
_pdbx_reference_entity_poly_link.entity_seq_num_2 
_pdbx_reference_entity_poly_link.value_order 
_pdbx_reference_entity_poly_link.component_id 
_pdbx_reference_entity_poly_link.details 
_pdbx_reference_entity_poly_link.insert_code_1 
_pdbx_reference_entity_poly_link.insert_code_2 
PRD_000487 1 1  C   ASP 1  N VLL 2  sing 1 ? ? ? 
PRD_000487 1 2  C   VLL 2  N CPI 3  sing 1 ? ? ? 
PRD_000487 1 3  NG2 VLL 2  C PRO 11 sing 1 ? ? ? 
PRD_000487 1 4  C   CPI 3  N 2AS 4  sing 1 ? ? ? 
PRD_000487 1 5  C   2AS 4  N ASP 5  sing 1 ? ? ? 
PRD_000487 1 6  C   ASP 5  N GLY 6  sing 1 ? ? ? 
PRD_000487 1 7  C   GLY 6  N ASP 7  sing 1 ? ? ? 
PRD_000487 1 8  C   ASP 7  N GLY 8  sing 1 ? ? ? 
PRD_000487 1 9  C   GLY 8  N VDL 9  sing 1 ? ? ? 
PRD_000487 1 10 C   VDL 9  N VAL 10 sing 1 ? ? ? 
PRD_000487 1 11 C   VAL 10 N PRO 11 sing 1 ? ? ? 
# 
_pdbx_reference_entity_poly.prd_id          PRD_000487 
_pdbx_reference_entity_poly.ref_entity_id   1 
_pdbx_reference_entity_poly.db_code         NOR00763 
_pdbx_reference_entity_poly.db_name         NOR 
_pdbx_reference_entity_poly.type            peptide-like 
# 
_pdbx_reference_entity_sequence.prd_id          PRD_000487 
_pdbx_reference_entity_sequence.ref_entity_id   1 
_pdbx_reference_entity_sequence.type            peptide-like 
_pdbx_reference_entity_sequence.NRP_flag        Y 
# 
loop_
_pdbx_reference_entity_poly_seq.prd_id 
_pdbx_reference_entity_poly_seq.ref_entity_id 
_pdbx_reference_entity_poly_seq.num 
_pdbx_reference_entity_poly_seq.mon_id 
_pdbx_reference_entity_poly_seq.parent_mon_id 
_pdbx_reference_entity_poly_seq.hetero 
_pdbx_reference_entity_poly_seq.observed 
PRD_000487 1 1  ASP ASP N Y 
PRD_000487 1 2  VLL THR N Y 
PRD_000487 1 3  CPI ?   N Y 
PRD_000487 1 4  2AS ASP N Y 
PRD_000487 1 5  ASP ASP N Y 
PRD_000487 1 6  GLY GLY N Y 
PRD_000487 1 7  ASP ASP N Y 
PRD_000487 1 8  GLY GLY N Y 
PRD_000487 1 9  VDL THR N Y 
PRD_000487 1 10 VAL VAL N Y 
PRD_000487 1 11 PRO PRO N Y 
# 
loop_
_pdbx_reference_entity_src_nat.prd_id 
_pdbx_reference_entity_src_nat.ref_entity_id 
_pdbx_reference_entity_src_nat.ordinal 
_pdbx_reference_entity_src_nat.taxid 
_pdbx_reference_entity_src_nat.organism_scientific 
_pdbx_reference_entity_src_nat.source 
_pdbx_reference_entity_src_nat.db_code 
_pdbx_reference_entity_src_nat.db_name 
_pdbx_reference_entity_src_nat.strain 
PRD_000487 1 1 ?      "Streptomyces strain Z-237" ? 210110   NADB   ? 
PRD_000487 1 2 196914 "ACTINOPLANES FRIULIENSIS"  ? NOR00763 Norine ? 
# 
loop_
_pdbx_prd_audit.prd_id 
_pdbx_prd_audit.date 
_pdbx_prd_audit.processing_site 
_pdbx_prd_audit.action_type 
PRD_000487 2012-02-01 RCSB "Create molecule"    
PRD_000487 2012-07-09 PDBE "Other modification" 
PRD_000487 2012-12-12 RCSB "Initial release"    
PRD_000487 2013-06-03 RCSB "Other modification" 
PRD_000487 2017-05-04 RCSB "Other modification" 
PRD_000487 2023-09-20 PDBE "Modify audit"       
# 
