data_PRD_000507
# 
_pdbx_reference_molecule.prd_id                       PRD_000507 
_pdbx_reference_molecule.name                         "PYOVERDIN C-E CHROMOPHORE" 
_pdbx_reference_molecule.represent_as                 polymer 
_pdbx_reference_molecule.type                         Polypeptide 
_pdbx_reference_molecule.type_evidence_code           ? 
_pdbx_reference_molecule.class                        "Metal Transport" 
_pdbx_reference_molecule.class_evidence_code          ? 
_pdbx_reference_molecule.formula                      "C55 H86 N17 O22" 
_pdbx_reference_molecule.formula_weight               1337.372 
_pdbx_reference_molecule.chem_comp_id                 ? 
_pdbx_reference_molecule.release_status               REL 
_pdbx_reference_molecule.replaces                     ? 
_pdbx_reference_molecule.replaced_by                  ? 
_pdbx_reference_molecule.compound_details             
;PYOVERDINES ARE A GROUP OF STRUCTURALLY RELATED SIDEROPHORES PRODUCED BY FLUORESCENT PSEUDOMONAS SPECIES. PYOVERDINE
IS NECESSARY FOR INFECTION IN SEVERAL DIFFERENT DISEASE MODELS. THE OCCURRENCE OF PYOVERDINE-DEFECTIVE STRAINS IN
CHRONIC INFECTIONS OF PATIENTS WITH CYSTIC FIBROSIS AND THE EXTREMELY HIGH SEQUENCE DIVERSITY OF GENES INVOLVED IN
PYOVERDINE SYNTHESIS AND UPTAKE INDICATE THAT PYOVERDINE PRODUCTION IS SUBJECT TO HIGH EVOLUTIONARY PRESSURE.
PYOVERDINE-DEPENDENT IRON TRANSPORT IS ALSO CRUCIAL FOR BIOFILM DEVELOPMENT, FURTHER EXPANDING THE IMPORTANCE OF THESE
SIDEROPHORES IN PSEUDOMONAS BIOLOGY.
;
_pdbx_reference_molecule.description                  
;IN IRON-DEFICIENT CONDITIONS, PSEUDOMONAS AERUGINOSA SECRETES A MAJOR FLUORESCENT SIDEROPHORE NAMED PYOVERDIN (PVD),
WHICH AFTER CHELATING IRON(III) IS TRANSPORTED BACK INTO THE CELL VIA ITS OUTER MEMBRANE RECEPTOR FPVA. FPVA IS A
TONB-DEPENDENT TRANSPORT PROTEIN AND HAS THE ABILITY TO BIND PVD IN ITS APO- OR IRON-LOADED FORM.
;
_pdbx_reference_molecule.representative_PDB_id_code   1xkh 
# 
loop_
_pdbx_reference_entity_list.prd_id 
_pdbx_reference_entity_list.ref_entity_id 
_pdbx_reference_entity_list.component_id 
_pdbx_reference_entity_list.type 
_pdbx_reference_entity_list.details 
PRD_000507 1 1 polymer     PYOVERDINE 
PRD_000507 2 2 non-polymer PVE        
# 
_pdbx_reference_entity_nonpoly.prd_id          PRD_000507 
_pdbx_reference_entity_nonpoly.ref_entity_id   2 
_pdbx_reference_entity_nonpoly.name            "(1S)-1-CARBOXY-5-[(3-CARBOXYPROPANOYL)AMINO]-8,9-DIHYDROXY-1,2,3,4-TETRAHYDROPYRIMIDO[1,2-A]QUINOLIN-11-IUM" 
_pdbx_reference_entity_nonpoly.chem_comp_id    PVE 
_pdbx_reference_entity_nonpoly.details         ? 
# 
_pdbx_reference_entity_link.prd_id              PRD_000507 
_pdbx_reference_entity_link.link_id             1 
_pdbx_reference_entity_link.link_class          PN 
_pdbx_reference_entity_link.ref_entity_id_1     1 
_pdbx_reference_entity_link.entity_seq_num_1    1 
_pdbx_reference_entity_link.comp_id_1           DSN 
_pdbx_reference_entity_link.atom_id_1           N 
_pdbx_reference_entity_link.ref_entity_id_2     2 
_pdbx_reference_entity_link.entity_seq_num_2    ? 
_pdbx_reference_entity_link.comp_id_2           PVE 
_pdbx_reference_entity_link.atom_id_2           C15 
_pdbx_reference_entity_link.value_order         sing 
_pdbx_reference_entity_link.component_1         1 
_pdbx_reference_entity_link.component_2         2 
_pdbx_reference_entity_link.details             ? 
_pdbx_reference_entity_link.nonpoly_res_num_1   ? 
_pdbx_reference_entity_link.nonpoly_res_num_2   ? 
# 
loop_
_pdbx_reference_entity_poly_link.prd_id 
_pdbx_reference_entity_poly_link.ref_entity_id 
_pdbx_reference_entity_poly_link.link_id 
_pdbx_reference_entity_poly_link.atom_id_1 
_pdbx_reference_entity_poly_link.comp_id_1 
_pdbx_reference_entity_poly_link.entity_seq_num_1 
_pdbx_reference_entity_poly_link.atom_id_2 
_pdbx_reference_entity_poly_link.comp_id_2 
_pdbx_reference_entity_poly_link.entity_seq_num_2 
_pdbx_reference_entity_poly_link.value_order 
_pdbx_reference_entity_poly_link.component_id 
_pdbx_reference_entity_poly_link.details 
_pdbx_reference_entity_poly_link.insert_code_1 
_pdbx_reference_entity_poly_link.insert_code_2 
PRD_000507 1 1 C  DSN 1 N ARG 2 sing 1 ? ? ? 
PRD_000507 1 2 C  ARG 2 N DSN 3 sing 1 ? ? ? 
PRD_000507 1 3 C  DSN 3 N FHO 4 sing 1 ? ? ? 
PRD_000507 1 4 C  FHO 4 N LYS 5 sing 1 ? ? ? 
PRD_000507 1 5 C  LYS 5 N FHO 6 sing 1 ? ? ? 
PRD_000507 1 6 NZ LYS 5 C THR 8 sing 1 ? ? ? 
PRD_000507 1 7 C  FHO 6 N THR 7 sing 1 ? ? ? 
PRD_000507 1 8 C  THR 7 N THR 8 sing 1 ? ? ? 
# 
_pdbx_reference_entity_poly.prd_id          PRD_000507 
_pdbx_reference_entity_poly.ref_entity_id   1 
_pdbx_reference_entity_poly.db_code         NOR00190 
_pdbx_reference_entity_poly.db_name         NOR 
_pdbx_reference_entity_poly.type            peptide-like 
# 
_pdbx_reference_entity_sequence.prd_id          PRD_000507 
_pdbx_reference_entity_sequence.ref_entity_id   1 
_pdbx_reference_entity_sequence.type            peptide-like 
_pdbx_reference_entity_sequence.NRP_flag        Y 
# 
loop_
_pdbx_reference_entity_poly_seq.prd_id 
_pdbx_reference_entity_poly_seq.ref_entity_id 
_pdbx_reference_entity_poly_seq.num 
_pdbx_reference_entity_poly_seq.mon_id 
_pdbx_reference_entity_poly_seq.parent_mon_id 
_pdbx_reference_entity_poly_seq.hetero 
_pdbx_reference_entity_poly_seq.observed 
PRD_000507 1 1 DSN SER N Y 
PRD_000507 1 2 ARG ARG N Y 
PRD_000507 1 3 DSN SER N Y 
PRD_000507 1 4 FHO LYS N Y 
PRD_000507 1 5 LYS LYS N Y 
PRD_000507 1 6 FHO LYS N Y 
PRD_000507 1 7 THR THR N Y 
PRD_000507 1 8 THR THR N Y 
# 
_pdbx_reference_entity_src_nat.prd_id                PRD_000507 
_pdbx_reference_entity_src_nat.ref_entity_id         1 
_pdbx_reference_entity_src_nat.ordinal               1 
_pdbx_reference_entity_src_nat.taxid                 287 
_pdbx_reference_entity_src_nat.organism_scientific   "Pseudomonas aeruginosa" 
_pdbx_reference_entity_src_nat.source                ? 
_pdbx_reference_entity_src_nat.db_code               NOR00190 
_pdbx_reference_entity_src_nat.db_name               Norine 
_pdbx_reference_entity_src_nat.strain                ? 
# 
loop_
_pdbx_prd_audit.prd_id 
_pdbx_prd_audit.date 
_pdbx_prd_audit.processing_site 
_pdbx_prd_audit.action_type 
PRD_000507 2012-02-03 RCSB "Create molecule"    
PRD_000507 2012-07-09 PDBE "Other modification" 
PRD_000507 2012-12-12 RCSB "Initial release"    
PRD_000507 2013-06-03 RCSB "Other modification" 
PRD_000507 2017-05-04 RCSB "Other modification" 
PRD_000507 2020-07-29 RCSB "Other modification" 
PRD_000507 2023-09-20 PDBE "Modify audit"       
# 
