data_PRD_000767
# 
_pdbx_reference_molecule.prd_id                       PRD_000767 
_pdbx_reference_molecule.name                         "CYCLOSPORIN A, 7 mutation" 
_pdbx_reference_molecule.represent_as                 polymer 
_pdbx_reference_molecule.type                         "Cyclic peptide" 
_pdbx_reference_molecule.type_evidence_code           ? 
_pdbx_reference_molecule.class                        Immunosuppressant 
_pdbx_reference_molecule.class_evidence_code          ? 
_pdbx_reference_molecule.formula                      "C63 H113 N11 O13" 
_pdbx_reference_molecule.formula_weight               1232.637 
_pdbx_reference_molecule.chem_comp_id                 ? 
_pdbx_reference_molecule.release_status               REL 
_pdbx_reference_molecule.replaces                     ? 
_pdbx_reference_molecule.replaced_by                  ? 
_pdbx_reference_molecule.compound_details             
;CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
HERE, CYCLOSPORIN A  IS REPRESENTED BY THE SEQUENCE (SEQRES)
;
_pdbx_reference_molecule.description                  
;CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
THE CYCLOSPORIN A WAS MODIFIED AT POSITION 7
TO BE N-METHYL-D-SERINE
;
_pdbx_reference_molecule.representative_PDB_id_code   1cwh 
# 
_pdbx_reference_entity_list.prd_id          PRD_000767 
_pdbx_reference_entity_list.ref_entity_id   1 
_pdbx_reference_entity_list.component_id    1 
_pdbx_reference_entity_list.type            polymer 
_pdbx_reference_entity_list.details         "PEPTIDE LIKE SEQUENCE RESIDUES 1 TO 11" 
# 
loop_
_pdbx_reference_entity_poly_link.prd_id 
_pdbx_reference_entity_poly_link.ref_entity_id 
_pdbx_reference_entity_poly_link.link_id 
_pdbx_reference_entity_poly_link.atom_id_1 
_pdbx_reference_entity_poly_link.comp_id_1 
_pdbx_reference_entity_poly_link.entity_seq_num_1 
_pdbx_reference_entity_poly_link.atom_id_2 
_pdbx_reference_entity_poly_link.comp_id_2 
_pdbx_reference_entity_poly_link.entity_seq_num_2 
_pdbx_reference_entity_poly_link.value_order 
_pdbx_reference_entity_poly_link.component_id 
_pdbx_reference_entity_poly_link.details 
_pdbx_reference_entity_poly_link.insert_code_1 
_pdbx_reference_entity_poly_link.insert_code_2 
PRD_000767 1 1  C DAL 1  N MLE 2  sing 1 ? ? ? 
PRD_000767 1 2  N DAL 1  C ALA 11 sing 1 ? ? ? 
PRD_000767 1 3  C MLE 2  N MLE 3  sing 1 ? ? ? 
PRD_000767 1 4  C MLE 3  N MVA 4  sing 1 ? ? ? 
PRD_000767 1 5  C MVA 4  N BMT 5  sing 1 ? ? ? 
PRD_000767 1 6  C BMT 5  N ABA 6  sing 1 ? ? ? 
PRD_000767 1 7  C ABA 6  N DSE 7  sing 1 ? ? ? 
PRD_000767 1 8  C DSE 7  N MLE 8  sing 1 ? ? ? 
PRD_000767 1 9  C MLE 8  N VAL 9  sing 1 ? ? ? 
PRD_000767 1 10 C VAL 9  N MLE 10 sing 1 ? ? ? 
PRD_000767 1 11 C MLE 10 N ALA 11 sing 1 ? ? ? 
# 
_pdbx_reference_entity_poly.prd_id          PRD_000767 
_pdbx_reference_entity_poly.ref_entity_id   1 
_pdbx_reference_entity_poly.db_code         NOR00033 
_pdbx_reference_entity_poly.db_name         NOR 
_pdbx_reference_entity_poly.type            peptide-like 
# 
_pdbx_reference_entity_sequence.prd_id          PRD_000767 
_pdbx_reference_entity_sequence.ref_entity_id   1 
_pdbx_reference_entity_sequence.type            peptide-like 
_pdbx_reference_entity_sequence.NRP_flag        Y 
# 
loop_
_pdbx_reference_entity_poly_seq.prd_id 
_pdbx_reference_entity_poly_seq.ref_entity_id 
_pdbx_reference_entity_poly_seq.num 
_pdbx_reference_entity_poly_seq.mon_id 
_pdbx_reference_entity_poly_seq.parent_mon_id 
_pdbx_reference_entity_poly_seq.hetero 
_pdbx_reference_entity_poly_seq.observed 
PRD_000767 1 1  DAL ALA N Y 
PRD_000767 1 2  MLE LEU N Y 
PRD_000767 1 3  MLE LEU N Y 
PRD_000767 1 4  MVA VAL N Y 
PRD_000767 1 5  BMT THR N Y 
PRD_000767 1 6  ABA THR N Y 
PRD_000767 1 7  DSE SER N Y 
PRD_000767 1 8  MLE LEU N Y 
PRD_000767 1 9  VAL VAL N Y 
PRD_000767 1 10 MLE LEU N Y 
PRD_000767 1 11 ALA ALA N Y 
# 
loop_
_pdbx_prd_audit.prd_id 
_pdbx_prd_audit.date 
_pdbx_prd_audit.processing_site 
_pdbx_prd_audit.action_type 
PRD_000767 2012-02-03 RCSB "Create molecule"    
PRD_000767 2012-07-09 PDBE "Other modification" 
PRD_000767 2012-12-12 RCSB "Initial release"    
PRD_000767 2013-06-03 RCSB "Other modification" 
PRD_000767 2017-05-04 RCSB "Other modification" 
PRD_000767 2023-09-20 PDBE "Modify audit"       
# 
