data_PRDCC_001068
# 
_chem_comp.id                                    PRD_001068 
_chem_comp.name                                  "beta-Hairpin Peptidomimetic Antibiotic TWLKKRRWKKAK(DPR)P" 
_chem_comp.formula                               "C87 H148 N27 O15" 
_chem_comp.formula_weight                        1812.278 
_chem_comp.pdbx_release_status                   REF_ONLY 
_chem_comp.type                                  peptide-like 
_chem_comp.pdbx_type                             ? 
_chem_comp.mon_nstd_parent_comp_id               ? 
_chem_comp.pdbx_synonyms                         ? 
_chem_comp.pdbx_formal_charge                    ? 
_chem_comp.pdbx_initial_date                     ? 
_chem_comp.pdbx_modified_date                    ? 
_chem_comp.pdbx_ambiguous_flag                   ? 
_chem_comp.pdbx_replaced_by                      ? 
_chem_comp.pdbx_replaces                         ? 
_chem_comp.one_letter_code                       ? 
_chem_comp.three_letter_code                     ? 
_chem_comp.pdbx_model_coordinates_details        ? 
_chem_comp.pdbx_model_coordinates_missing_flag   ? 
_chem_comp.pdbx_ideal_coordinates_details        ? 
_chem_comp.pdbx_ideal_coordinates_missing_flag   ? 
_chem_comp.pdbx_model_coordinates_db_code        ? 
_chem_comp.pdbx_subcomponent_list                ? 
_chem_comp.pdbx_pcm                              ? 
_chem_comp.pdbx_processing_site                  ? 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.alt_atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.charge 
_chem_comp_atom.pdbx_align 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_leaving_atom_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.model_Cartn_x 
_chem_comp_atom.model_Cartn_y 
_chem_comp_atom.model_Cartn_z 
_chem_comp_atom.pdbx_model_Cartn_x_ideal 
_chem_comp_atom.pdbx_model_Cartn_y_ideal 
_chem_comp_atom.pdbx_model_Cartn_z_ideal 
_chem_comp_atom.pdbx_component_comp_id 
_chem_comp_atom.pdbx_residue_numbering 
_chem_comp_atom.pdbx_component_atom_id 
_chem_comp_atom.pdbx_polymer_type 
_chem_comp_atom.pdbx_ref_id 
_chem_comp_atom.pdbx_component_id 
_chem_comp_atom.pdbx_ordinal 
_chem_comp_atom.pdbx_backbone_atom_flag 
_chem_comp_atom.pdbx_n_terminal_atom_flag 
_chem_comp_atom.pdbx_c_terminal_atom_flag 
PRD_001068 N1   N1   N 0 1 N N N 7.405   -2.590 1.209   7.328   3.364   0.289  THR 1  N    polymer 1 1 1   ? ? ? 
PRD_001068 C1   C1   C 0 1 N N S 6.897   -3.169 -0.023  6.227   3.932   -0.511 THR 1  CA   polymer 1 1 2   ? ? ? 
PRD_001068 C2   C2   C 0 1 N N N 5.461   -2.707 -0.277  5.434   4.896   0.337  THR 1  C    polymer 1 1 3   ? ? ? 
PRD_001068 O1   O1   O 0 1 N N N 4.590   -2.878 0.574   5.458   4.820   1.547  THR 1  O    polymer 1 1 4   ? ? ? 
PRD_001068 C3   C3   C 0 1 N N R 7.039   -4.690 0.075   5.306   2.810   -0.993 THR 1  CB   polymer 1 1 5   ? ? ? 
PRD_001068 O2   O2   O 0 1 N N N 8.245   -4.972 -0.628  4.674   2.196   0.132  THR 1  OG1  polymer 1 1 6   ? ? ? 
PRD_001068 C4   C4   C 0 1 N N N 5.961   -5.430 -0.720  6.129   1.765   -1.749 THR 1  CG2  polymer 1 1 7   ? ? ? 
PRD_001068 N2   N2   N 0 1 N N N 5.257   -2.131 -1.453  4.689   5.845   -0.297 TRP 2  N    polymer 1 1 8   ? ? ? 
PRD_001068 C5   C5   C 0 1 N N S 3.942   -1.643 -1.830  3.882   6.751   0.543  TRP 2  CA   polymer 1 1 9   ? ? ? 
PRD_001068 C6   C6   C 0 1 N N N 2.943   -2.786 -1.641  2.632   7.118   -0.218 TRP 2  C    polymer 1 1 10  ? ? ? 
PRD_001068 O3   O3   O 0 1 N N N 3.311   -3.870 -1.190  2.704   7.839   -1.189 TRP 2  O    polymer 1 1 11  ? ? ? 
PRD_001068 C7   C7   C 0 1 N N N 3.951   -1.087 -3.255  4.681   8.019   0.856  TRP 2  CB   polymer 1 1 12  ? ? ? 
PRD_001068 C8   C8   C 0 1 Y N N 3.170   -1.935 -4.260  5.878   7.662   1.699  TRP 2  CG   polymer 1 1 13  ? ? ? 
PRD_001068 C9   C9   C 0 1 Y N N 3.421   -3.193 -4.650  5.955   7.711   3.039  TRP 2  CD1  polymer 1 1 14  ? ? ? 
PRD_001068 C10  C10  C 0 1 Y N N 1.992   -1.535 -4.991  7.177   7.191   1.213  TRP 2  CD2  polymer 1 1 15  ? ? ? 
PRD_001068 N3   N3   N 0 1 Y N N 2.496   -3.630 -5.575  7.198   7.314   3.450  TRP 2  NE1  polymer 1 1 16  ? ? ? 
PRD_001068 C11  C11  C 0 1 Y N N 1.599   -2.590 -5.790  7.971   6.990   2.357  TRP 2  CE2  polymer 1 1 17  ? ? ? 
PRD_001068 C12  C12  C 0 1 Y N N 1.282   -0.322 -4.979  7.705   6.935   -0.054 TRP 2  CE3  polymer 1 1 18  ? ? ? 
PRD_001068 C13  C13  C 0 1 Y N N 0.484   -2.539 -6.635  9.278   6.536   2.209  TRP 2  CZ2  polymer 1 1 19  ? ? ? 
PRD_001068 C14  C14  C 0 1 Y N N 0.171   -0.286 -5.829  8.991   6.491   -0.177 TRP 2  CZ3  polymer 1 1 20  ? ? ? 
PRD_001068 C15  C15  C 0 1 Y N N -0.238  -1.339 -6.639  9.778   6.290   0.949  TRP 2  CH2  polymer 1 1 21  ? ? ? 
PRD_001068 N4   N4   N 0 1 N N N 1.697   -2.504 -1.996  1.430   6.634   0.200  LEU 3  N    polymer 1 1 22  ? ? ? 
PRD_001068 C16  C16  C 0 1 N N S 0.641   -3.495 -1.871  0.255   6.982   -0.624 LEU 3  CA   polymer 1 1 23  ? ? ? 
PRD_001068 C17  C17  C 0 1 N N N -0.694  -2.865 -2.271  -0.984  6.910   0.229  LEU 3  C    polymer 1 1 24  ? ? ? 
PRD_001068 O4   O4   O 0 1 N N N -1.374  -3.362 -3.167  -0.904  6.595   1.398  LEU 3  O    polymer 1 1 25  ? ? ? 
PRD_001068 C18  C18  C 0 1 N N N 0.638   -4.100 -0.465  0.133   5.992   -1.784 LEU 3  CB   polymer 1 1 26  ? ? ? 
PRD_001068 C19  C19  C 0 1 N N N 0.708   -5.626 -0.391  0.128   4.563   -1.236 LEU 3  CG   polymer 1 1 27  ? ? ? 
PRD_001068 C20  C20  C 0 1 N N N 2.061   -6.137 -0.891  -1.161  4.324   -0.448 LEU 3  CD1  polymer 1 1 28  ? ? ? 
PRD_001068 C21  C21  C 0 1 N N N 0.394   -6.123 1.021   0.207   3.571   -2.398 LEU 3  CD2  polymer 1 1 29  ? ? ? 
PRD_001068 N5   N5   N 0 1 N N N -1.028  -1.779 -1.588  -2.191  7.203   -0.326 LYS 4  N    polymer 1 1 30  ? ? ? 
PRD_001068 C22  C22  C 0 1 N N S -2.270  -1.076 -1.862  -3.385  7.050   0.526  LYS 4  CA   polymer 1 1 31  ? ? ? 
PRD_001068 C23  C23  C 0 1 N N N -3.451  -2.012 -1.598  -4.410  6.225   -0.215 LYS 4  C    polymer 1 1 32  ? ? ? 
PRD_001068 O5   O5   O 0 1 N N N -3.743  -2.893 -2.408  -5.005  6.697   -1.159 LYS 4  O    polymer 1 1 33  ? ? ? 
PRD_001068 C24  C24  C 0 1 N N N -2.253  -0.491 -3.276  -3.973  8.429   0.835  LYS 4  CB   polymer 1 1 34  ? ? ? 
PRD_001068 C25  C25  C 0 1 N N N -3.574  0.212  -3.593  -2.977  9.231   1.674  LYS 4  CG   polymer 1 1 35  ? ? ? 
PRD_001068 C26  C26  C 0 1 N N N -3.494  0.953  -4.930  -3.565  10.610  1.983  LYS 4  CD   polymer 1 1 36  ? ? ? 
PRD_001068 C27  C27  C 0 1 N N N -4.442  0.334  -5.959  -2.569  11.412  2.823  LYS 4  CE   polymer 1 1 37  ? ? ? 
PRD_001068 N6   N6   N 1 1 N N N -5.013  1.381  -6.834  -3.133  12.736  3.120  LYS 4  NZ   polymer 1 1 38  ? ? ? 
PRD_001068 N7   N7   N 0 1 N N N -4.098  -1.793 -0.464  -4.650  4.950   0.200  LYS 5  N    polymer 1 1 39  ? ? ? 
PRD_001068 C28  C28  C 0 1 N N S -5.240  -2.606 -0.083  -5.609  4.160   -0.599 LYS 5  CA   polymer 1 1 40  ? ? ? 
PRD_001068 C29  C29  C 0 1 N N N -6.131  -1.810 0.873   -6.203  3.086   0.277  LYS 5  C    polymer 1 1 41  ? ? ? 
PRD_001068 O6   O6   O 0 1 N N N -7.324  -1.644 0.623   -5.874  2.999   1.442  LYS 5  O    polymer 1 1 42  ? ? ? 
PRD_001068 C30  C30  C 0 1 N N N -4.776  -3.950 0.483   -4.881  3.512   -1.779 LYS 5  CB   polymer 1 1 43  ? ? ? 
PRD_001068 C31  C31  C 0 1 N N N -5.818  -5.040 0.229   -4.369  4.601   -2.724 LYS 5  CG   polymer 1 1 44  ? ? ? 
PRD_001068 C32  C32  C 0 1 N N N -5.153  -6.409 0.070   -3.641  3.953   -3.903 LYS 5  CD   polymer 1 1 45  ? ? ? 
PRD_001068 C33  C33  C 0 1 N N N -5.217  -7.205 1.374   -3.128  5.042   -4.847 LYS 5  CE   polymer 1 1 46  ? ? ? 
PRD_001068 N8   N8   N 1 1 N N N -5.629  -8.602 1.109   -2.429  4.419   -5.979 LYS 5  NZ   polymer 1 1 47  ? ? ? 
PRD_001068 N9   N9   N 0 1 N N N -5.517  -1.340 1.949   -7.105  2.218   -0.254 ARG 6  N    polymer 1 1 48  ? ? ? 
PRD_001068 C34  C34  C 0 1 N N S -6.240  -0.566 2.945   -7.615  1.150   0.628  ARG 6  CA   polymer 1 1 49  ? ? ? 
PRD_001068 C35  C35  C 0 1 N N N -5.383  0.606  3.430   -7.549  -0.159  -0.119 ARG 6  C    polymer 1 1 50  ? ? ? 
PRD_001068 O7   O7   O 0 1 N N N -4.586  0.455  4.354   -8.261  -0.348  -1.082 ARG 6  O    polymer 1 1 51  ? ? ? 
PRD_001068 C36  C36  C 0 1 N N N -6.628  -1.435 4.142   -9.067  1.444   1.008  ARG 6  CB   polymer 1 1 52  ? ? ? 
PRD_001068 C37  C37  C 0 1 N N N -8.036  -1.094 4.634   -9.126  2.721   1.849  ARG 6  CG   polymer 1 1 53  ? ? ? 
PRD_001068 C38  C38  C 0 1 N N N -9.017  -2.223 4.314   -10.578 3.015   2.229  ARG 6  CD   polymer 1 1 54  ? ? ? 
PRD_001068 N10  N10  N 0 1 N N N -10.392 -1.683 4.205   -10.634 4.238   3.034  ARG 6  NE   polymer 1 1 55  ? ? ? 
PRD_001068 C39  C39  C 0 1 N N N -11.454 -2.407 3.828   -11.837 4.701   3.492  ARG 6  CZ   polymer 1 1 56  ? ? ? 
PRD_001068 N11  N11  N 0 1 N N N -11.309 -3.703 3.522   -12.957 4.040   3.206  ARG 6  NH1  polymer 1 1 57  ? ? ? 
PRD_001068 N12  N12  N 1 1 N N N -12.664 -1.833 3.757   -11.887 5.813   4.224  ARG 6  NH2  polymer 1 1 58  ? ? ? 
PRD_001068 N13  N13  N 0 1 N N N -5.578  1.746  2.785   -6.679  -1.117  0.305  ARG 7  N    polymer 1 1 59  ? ? ? 
PRD_001068 C40  C40  C 0 1 N N S -4.834  2.943  3.139   -6.621  -2.358  -0.496 ARG 7  CA   polymer 1 1 60  ? ? ? 
PRD_001068 C41  C41  C 0 1 N N N -3.475  2.950  2.436   -6.151  -3.482  0.390  ARG 7  C    polymer 1 1 61  ? ? ? 
PRD_001068 O8   O8   O 0 1 N N N -2.828  3.992  2.339   -5.896  -3.272  1.557  ARG 7  O    polymer 1 1 62  ? ? ? 
PRD_001068 C42  C42  C 0 1 N N N -4.619  3.031  4.651   -5.640  -2.174  -1.657 ARG 7  CB   polymer 1 1 63  ? ? ? 
PRD_001068 C43  C43  C 0 1 N N N -4.890  4.447  5.162   -6.171  -1.103  -2.611 ARG 7  CG   polymer 1 1 64  ? ? ? 
PRD_001068 C44  C44  C 0 1 N N N -3.748  4.934  6.058   -5.190  -0.920  -3.771 ARG 7  CD   polymer 1 1 65  ? ? ? 
PRD_001068 N14  N14  N 0 1 N N N -4.297  5.599  7.260   -5.700  0.106   -4.684 ARG 7  NE   polymer 1 1 66  ? ? ? 
PRD_001068 C45  C45  C 0 1 N N N -3.558  6.286  8.143   -4.986  0.442   -5.802 ARG 7  CZ   polymer 1 1 67  ? ? ? 
PRD_001068 N15  N15  N 0 1 N N N -2.234  6.399  7.963   -3.829  -0.164  -6.060 ARG 7  NH1  polymer 1 1 68  ? ? ? 
PRD_001068 N16  N16  N 1 1 N N N -4.142  6.857  9.205   -5.449  1.374   -6.632 ARG 7  NH2  polymer 1 1 69  ? ? ? 
PRD_001068 N17  N17  N 0 1 N N N -3.081  1.776  1.967   -6.016  -4.732  -0.131 TRP 8  N    polymer 1 1 70  ? ? ? 
PRD_001068 C46  C46  C 0 1 N N S -1.810  1.633  1.276   -5.507  -5.782  0.771  TRP 8  CA   polymer 1 1 71  ? ? ? 
PRD_001068 C47  C47  C 0 1 N N N -1.999  2.111  -0.164  -4.443  -6.571  0.049  TRP 8  C    polymer 1 1 72  ? ? ? 
PRD_001068 O9   O9   O 0 1 N N N -3.091  2.003  -0.720  -4.746  -7.310  -0.864 TRP 8  O    polymer 1 1 73  ? ? ? 
PRD_001068 C48  C48  C 0 1 N N N -1.295  0.196  1.367   -6.650  -6.716  1.168  TRP 8  CB   polymer 1 1 74  ? ? ? 
PRD_001068 C49  C49  C 0 1 Y N N -0.569  -0.124 2.676   -7.665  -5.952  1.980  TRP 8  CG   polymer 1 1 75  ? ? ? 
PRD_001068 C50  C50  C 0 1 Y N N 0.491   0.501  3.205   -7.729  -5.884  3.319  TRP 8  CD1  polymer 1 1 76  ? ? ? 
PRD_001068 C51  C51  C 0 1 Y N N -0.895  -1.179 3.604   -8.763  -5.136  1.457  TRP 8  CD2  polymer 1 1 77  ? ? ? 
PRD_001068 N18  N18  N 0 1 Y N N 0.871   -0.071 4.402   -8.782  -5.097  3.697  TRP 8  NE1  polymer 1 1 78  ? ? ? 
PRD_001068 C52  C52  C 0 1 Y N N 0.000   -1.125 4.652   -9.436  -4.624  2.581  TRP 8  CE2  polymer 1 1 79  ? ? ? 
PRD_001068 C53  C53  C 0 1 Y N N -1.915  -2.146 3.561   -9.209  -4.816  0.173  TRP 8  CE3  polymer 1 1 80  ? ? ? 
PRD_001068 C54  C54  C 0 1 Y N N -0.032  -2.012 5.735   -10.542 -3.800  2.397  TRP 8  CZ2  polymer 1 1 81  ? ? ? 
PRD_001068 C55  C55  C 0 1 Y N N -1.933  -3.026 4.651   -10.297 -4.006  0.015  TRP 8  CZ3  polymer 1 1 82  ? ? ? 
PRD_001068 C56  C56  C 0 1 Y N N -1.038  -2.985 5.713   -10.964 -3.496  1.121  TRP 8  CH2  polymer 1 1 83  ? ? ? 
PRD_001068 N19  N19  N 0 1 N N N -0.918  2.629  -0.729  -3.146  -6.434  0.441  LYS 9  N    polymer 1 1 84  ? ? ? 
PRD_001068 C57  C57  C 0 1 N N S -0.951  3.124  -2.094  -2.137  -7.185  -0.332 LYS 9  CA   polymer 1 1 85  ? ? ? 
PRD_001068 C58  C58  C 0 1 N N N 0.306   2.656  -2.832  -0.893  -7.336  0.507  LYS 9  C    polymer 1 1 86  ? ? ? 
PRD_001068 O10  O10  O 0 1 N N N 0.811   1.565  -2.574  -0.839  -6.847  1.616  LYS 9  O    polymer 1 1 87  ? ? ? 
PRD_001068 C59  C59  C 0 1 N N N -1.144  4.642  -2.110  -1.794  -6.416  -1.612 LYS 9  CB   polymer 1 1 88  ? ? ? 
PRD_001068 C60  C60  C 0 1 N N N -2.065  5.065  -3.257  -3.028  -6.353  -2.514 LYS 9  CG   polymer 1 1 89  ? ? ? 
PRD_001068 C61  C61  C 0 1 N N N -3.417  5.543  -2.726  -2.686  -5.586  -3.793 LYS 9  CD   polymer 1 1 90  ? ? ? 
PRD_001068 C62  C62  C 0 1 N N N -4.421  4.390  -2.663  -3.920  -5.522  -4.695 LYS 9  CE   polymer 1 1 91  ? ? ? 
PRD_001068 N20  N20  N 1 1 N N N -5.407  4.501  -3.761  -3.591  -4.786  -5.923 LYS 9  NZ   polymer 1 1 92  ? ? ? 
PRD_001068 N21  N21  N 0 1 N N N 0.773   3.505  -3.735  0.161   -8.032  0.003  LYS 10 N    polymer 1 1 93  ? ? ? 
PRD_001068 C63  C63  C 0 1 N N S 1.961   3.193  -4.511  1.406   -8.049  0.795  LYS 10 CA   polymer 1 1 94  ? ? ? 
PRD_001068 C64  C64  C 0 1 N N N 3.085   2.760  -3.567  2.493   -7.411  -0.033 LYS 10 C    polymer 1 1 95  ? ? ? 
PRD_001068 O11  O11  O 0 1 N N N 2.897   2.719  -2.352  2.631   -7.732  -1.193 LYS 10 O    polymer 1 1 96  ? ? ? 
PRD_001068 C65  C65  C 0 1 N N N 2.337   4.370  -5.414  1.792   -9.491  1.123  LYS 10 CB   polymer 1 1 97  ? ? ? 
PRD_001068 C66  C66  C 0 1 N N N 2.696   3.890  -6.821  0.729   -10.108 2.034  LYS 10 CG   polymer 1 1 98  ? ? ? 
PRD_001068 C67  C67  C 0 1 N N N 1.583   4.226  -7.815  1.114   -11.552 2.362  LYS 10 CD   polymer 1 1 99  ? ? ? 
PRD_001068 C68  C68  C 0 1 N N N 2.010   3.902  -9.248  0.051   -12.170 3.273  LYS 10 CE   polymer 1 1 100 ? ? ? 
PRD_001068 N22  N22  N 1 1 N N N 0.947   3.147  -9.948  0.421   -13.556 3.588  LYS 10 NZ   polymer 1 1 101 ? ? ? 
PRD_001068 N23  N23  N 0 1 N N N 4.226   2.447  -4.160  3.312   -6.479  0.530  ALA 11 N    polymer 1 1 102 ? ? ? 
PRD_001068 C69  C69  C 0 1 N N S 5.379   2.019  -3.387  4.225   -5.786  -0.399 ALA 11 CA   polymer 1 1 103 ? ? ? 
PRD_001068 C70  C70  C 0 1 N N N 5.476   2.862  -2.114  5.510   -5.444  0.310  ALA 11 C    polymer 1 1 104 ? ? ? 
PRD_001068 O12  O12  O 0 1 N N N 5.498   4.090  -2.178  5.660   -5.704  1.483  ALA 11 O    polymer 1 1 105 ? ? ? 
PRD_001068 C71  C71  C 0 1 N N N 6.639   2.118  -4.248  3.563   -4.502  -0.905 ALA 11 CB   polymer 1 1 106 ? ? ? 
PRD_001068 N24  N24  N 0 1 N N N 5.530   2.169  -0.986  6.489   -4.833  -0.408 LYS 12 N    polymer 1 1 107 ? ? ? 
PRD_001068 C72  C72  C 0 1 N N S 5.624   2.839  0.300   7.773   -4.548  0.263  LYS 12 CA   polymer 1 1 108 ? ? ? 
PRD_001068 C73  C73  C 0 1 N N N 6.424   1.965  1.269   8.303   -3.248  -0.286 LYS 12 C    polymer 1 1 109 ? ? ? 
PRD_001068 O13  O13  O 0 1 N N N 5.922   1.091  1.976   7.737   -2.736  -1.236 LYS 12 O    polymer 1 1 110 ? ? ? 
PRD_001068 C74  C74  C 0 1 N N N 4.232   3.210  0.814   8.753   -5.681  -0.049 LYS 12 CB   polymer 1 1 111 ? ? ? 
PRD_001068 C75  C75  C 0 1 N N N 4.323   4.160  2.010   8.242   -6.983  0.572  LYS 12 CG   polymer 1 1 112 ? ? ? 
PRD_001068 C76  C76  C 0 1 N N N 4.360   3.382  3.327   9.222   -8.116  0.260  LYS 12 CD   polymer 1 1 113 ? ? ? 
PRD_001068 C77  C77  C 0 1 N N N 4.389   4.333  4.525   8.711   -9.417  0.881  LYS 12 CE   polymer 1 1 114 ? ? ? 
PRD_001068 N25  N25  N 1 1 N N N 3.720   3.716  5.693   9.651   -10.505 0.581  LYS 12 NZ   polymer 1 1 115 ? ? ? 
PRD_001068 N26  N26  N 0 1 N N N 7.760   2.219  1.302   9.376   -2.641  0.243  DPR 13 N    polymer 1 1 116 ? ? ? 
PRD_001068 C78  C78  C 0 1 N N R 8.668   1.586  2.305   10.058  -1.474  -0.333 DPR 13 CA   polymer 1 1 117 ? ? ? 
PRD_001068 C79  C79  C 0 1 N N N 9.905   2.502  2.174   11.530  -1.587  0.093  DPR 13 CB   polymer 1 1 118 ? ? ? 
PRD_001068 C80  C80  C 0 1 N N N 9.930   2.928  0.703   11.559  -2.612  1.243  DPR 13 CG   polymer 1 1 119 ? ? ? 
PRD_001068 C81  C81  C 0 1 N N N 8.456   3.102  0.342   10.086  -2.998  1.474  DPR 13 CD   polymer 1 1 120 ? ? ? 
PRD_001068 C82  C82  C 0 1 N N N 8.940   0.053  2.088   9.465   -0.200  0.212  DPR 13 C    polymer 1 1 121 ? ? ? 
PRD_001068 O14  O14  O 0 1 N N N 9.500   -0.375 1.078   8.564   -0.252  1.023  DPR 13 O    polymer 1 1 122 ? ? ? 
PRD_001068 N27  N27  N 0 1 N N N 8.552   -0.771 3.082   9.929   0.993   -0.199 PRO 14 N    polymer 1 1 123 ? ? ? 
PRD_001068 C83  C83  C 0 1 N N S 8.914   -2.213 3.096   9.564   2.307   0.349  PRO 14 CA   polymer 1 1 124 ? ? ? 
PRD_001068 C84  C84  C 0 1 N N N 8.445   -3.090 1.884   8.400   2.888   -0.407 PRO 14 C    polymer 1 1 125 ? ? ? 
PRD_001068 O15  O15  O 0 1 N N N 9.102   -4.055 1.507   8.423   2.938   -1.618 PRO 14 O    polymer 1 1 126 ? ? ? 
PRD_001068 C85  C85  C 0 1 N N N 8.344   -2.641 4.467   10.794  3.214   0.145  PRO 14 CB   polymer 1 1 127 ? ? ? 
PRD_001068 C86  C86  C 0 1 N N N 7.196   -1.669 4.767   11.576  2.564   -1.009 PRO 14 CG   polymer 1 1 128 ? ? ? 
PRD_001068 C87  C87  C 0 1 N N N 7.654   -0.338 4.166   10.896  1.214   -1.283 PRO 14 CD   polymer 1 1 129 ? ? ? 
PRD_001068 H1   H1   H 0 1 N N N 6.953   -1.775 1.571   7.296   3.332   1.260  THR 1  H    polymer 1 1 130 ? ? ? 
PRD_001068 H2   H2   H 0 1 N N N 7.518   -2.824 -0.863  6.638   4.462   -1.370 THR 1  HA   polymer 1 1 131 ? ? ? 
PRD_001068 H3   H3   H 0 1 N N N 7.064   -5.023 1.123   4.546   3.223   -1.656 THR 1  HB   polymer 1 1 132 ? ? ? 
PRD_001068 H4   H4   H 0 1 N N N 8.990   -4.733 -0.089  4.135   2.801   0.659  THR 1  HG1  polymer 1 1 133 ? ? ? 
PRD_001068 H5   H5   H 0 0 N N N 6.108   -6.515 -0.616  6.889   1.351   -1.086 THR 1  HG21 polymer 1 1 134 ? ? ? 
PRD_001068 H6   H6   H 0 0 N N N 4.968   -5.156 -0.334  5.473   0.965   -2.092 THR 1  HG22 polymer 1 1 135 ? ? ? 
PRD_001068 H7   H7   H 0 0 N N N 6.032   -5.150 -1.782  6.611   2.233   -2.607 THR 1  HG23 polymer 1 1 136 ? ? ? 
PRD_001068 H8   H8   H 0 1 N N N 6.021   -2.031 -2.091  4.688   5.920   -1.264 TRP 2  H    polymer 1 1 137 ? ? ? 
PRD_001068 H9   H9   H 0 1 N N N 3.656   -0.827 -1.150  3.609   6.250   1.471  TRP 2  HA   polymer 1 1 138 ? ? ? 
PRD_001068 H10  H10  H 0 1 N N N 3.509   -0.080 -3.236  5.016   8.477   -0.075 TRP 2  HB2  polymer 1 1 139 ? ? ? 
PRD_001068 H11  H11  H 0 1 N N N 4.995   -1.023 -3.594  4.050   8.721   1.400  TRP 2  HB3  polymer 1 1 140 ? ? ? 
PRD_001068 H12  H12  H 0 1 N N N 4.244   -3.789 -4.286  5.153   8.018   3.695  TRP 2  HD1  polymer 1 1 141 ? ? ? 
PRD_001068 H13  H13  H 0 1 N N N 2.475   -4.530 -6.011  7.491   7.267   4.373  TRP 2  HE1  polymer 1 1 142 ? ? ? 
PRD_001068 H14  H14  H 0 1 N N N 1.571   0.516  -4.362  7.098   7.089   -0.935 TRP 2  HE3  polymer 1 1 143 ? ? ? 
PRD_001068 H15  H15  H 0 1 N N N 0.196   -3.379 -7.250  9.898   6.377   3.079  TRP 2  HZ2  polymer 1 1 144 ? ? ? 
PRD_001068 H16  H16  H 0 1 N N N -0.410  0.624  -5.858  9.398   6.293   -1.157 TRP 2  HZ3  polymer 1 1 145 ? ? ? 
PRD_001068 H17  H17  H 0 1 N N N -1.109  -1.232 -7.269  10.792  5.937   0.837  TRP 2  HH2  polymer 1 1 146 ? ? ? 
PRD_001068 H18  H18  H 0 1 N N N 1.481   -1.596 -2.355  1.356   6.086   0.999  LEU 3  H    polymer 1 1 147 ? ? ? 
PRD_001068 H19  H19  H 0 1 N N N 0.846   -4.311 -2.580  0.367   7.993   -1.016 LEU 3  HA   polymer 1 1 148 ? ? ? 
PRD_001068 H20  H20  H 0 1 N N N 1.506   -3.697 0.077   -0.795  6.177   -2.324 LEU 3  HB2  polymer 1 1 149 ? ? ? 
PRD_001068 H21  H21  H 0 1 N N N -0.288  -3.781 0.037   0.979   6.118   -2.461 LEU 3  HB3  polymer 1 1 150 ? ? ? 
PRD_001068 H22  H22  H 0 1 N N N -0.066  -6.026 -1.063  0.987   4.423   -0.580 LEU 3  HG   polymer 1 1 151 ? ? ? 
PRD_001068 H23  H23  H 0 0 N N N 2.085   -7.235 -0.827  -2.006  4.737   -0.999 LEU 3  HD11 polymer 1 1 152 ? ? ? 
PRD_001068 H24  H24  H 0 0 N N N 2.206   -5.827 -1.936  -1.308  3.253   -0.308 LEU 3  HD12 polymer 1 1 153 ? ? ? 
PRD_001068 H25  H25  H 0 0 N N N 2.864   -5.716 -0.269  -1.088  4.811   0.524  LEU 3  HD13 polymer 1 1 154 ? ? ? 
PRD_001068 H26  H26  H 0 0 N N N 0.451   -7.221 1.045   1.126   3.741   -2.960 LEU 3  HD21 polymer 1 1 155 ? ? ? 
PRD_001068 H27  H27  H 0 0 N N N 1.124   -5.702 1.728   0.203   2.553   -2.008 LEU 3  HD22 polymer 1 1 156 ? ? ? 
PRD_001068 H28  H28  H 0 0 N N N -0.619  -5.803 1.305   -0.652  3.711   -3.055 LEU 3  HD23 polymer 1 1 157 ? ? ? 
PRD_001068 H29  H29  H 0 1 N N N -0.416  -1.439 -0.874  -2.268  7.504   -1.247 LYS 4  H    polymer 1 1 158 ? ? ? 
PRD_001068 H30  H30  H 0 1 N N N -2.354  -0.234 -1.159  -3.119  6.549   1.455  LYS 4  HA   polymer 1 1 159 ? ? ? 
PRD_001068 H31  H31  H 0 1 N N N -1.431  0.235  -3.355  -4.170  8.957   -0.098 LYS 4  HB2  polymer 1 1 160 ? ? ? 
PRD_001068 H32  H32  H 0 1 N N N -2.095  -1.304 -4.000  -4.904  8.311   1.389  LYS 4  HB3  polymer 1 1 161 ? ? ? 
PRD_001068 H33  H33  H 0 1 N N N -4.377  -0.538 -3.645  -2.780  8.703   2.607  LYS 4  HG2  polymer 1 1 162 ? ? ? 
PRD_001068 H34  H34  H 0 1 N N N -3.798  0.934  -2.794  -2.046  9.349   1.120  LYS 4  HG3  polymer 1 1 163 ? ? ? 
PRD_001068 H35  H35  H 0 1 N N N -3.771  2.006  -4.774  -3.762  11.138  1.051  LYS 4  HD2  polymer 1 1 164 ? ? ? 
PRD_001068 H36  H36  H 0 1 N N N -2.464  0.897  -5.311  -4.496  10.492  2.538  LYS 4  HD3  polymer 1 1 165 ? ? ? 
PRD_001068 H37  H37  H 0 1 N N N -3.886  -0.388 -6.575  -2.372  10.884  3.756  LYS 4  HE2  polymer 1 1 166 ? ? ? 
PRD_001068 H38  H38  H 0 1 N N N -5.258  -0.183 -5.434  -1.638  11.530  2.269  LYS 4  HE3  polymer 1 1 167 ? ? ? 
PRD_001068 H39  H39  H 0 1 N N N -5.629  0.960  -7.500  -3.315  13.225  2.256  LYS 4  HZ1  polymer 1 1 168 ? ? ? 
PRD_001068 H40  H40  H 0 1 N N N -5.522  2.039  -6.278  -3.995  12.627  3.633  LYS 4  HZ2  polymer 1 1 169 ? ? ? 
PRD_001068 H41  H41  H 0 1 N N N -4.274  1.852  -7.316  -2.476  13.265  3.674  LYS 4  HZ3  polymer 1 1 170 ? ? ? 
PRD_001068 H42  H42  H 0 1 N N N -3.796  -1.056 0.140   -4.211  4.579   0.983  LYS 5  H    polymer 1 1 171 ? ? ? 
PRD_001068 H43  H43  H 0 1 N N N -5.832  -2.816 -0.986  -6.403  4.808   -0.969 LYS 5  HA   polymer 1 1 172 ? ? ? 
PRD_001068 H44  H44  H 0 1 N N N -3.830  -4.237 -0.000  -4.039  2.926   -1.409 LYS 5  HB2  polymer 1 1 173 ? ? ? 
PRD_001068 H45  H45  H 0 1 N N N -4.618  -3.849 1.567   -5.569  2.859   -2.317 LYS 5  HB3  polymer 1 1 174 ? ? ? 
PRD_001068 H46  H46  H 0 1 N N N -6.516  -5.076 1.079   -5.210  5.186   -3.093 LYS 5  HG2  polymer 1 1 175 ? ? ? 
PRD_001068 H47  H47  H 0 1 N N N -6.372  -4.800 -0.691  -3.680  5.253   -2.186 LYS 5  HG3  polymer 1 1 176 ? ? ? 
PRD_001068 H48  H48  H 0 1 N N N -5.672  -6.971 -0.720  -2.799  3.367   -3.533 LYS 5  HD2  polymer 1 1 177 ? ? ? 
PRD_001068 H49  H49  H 0 1 N N N -4.100  -6.266 -0.213  -4.329  3.300   -4.440 LYS 5  HD3  polymer 1 1 178 ? ? ? 
PRD_001068 H50  H50  H 0 1 N N N -4.224  -7.204 1.848   -3.970  5.627   -5.217 LYS 5  HE2  polymer 1 1 179 ? ? ? 
PRD_001068 H51  H51  H 0 1 N N N -5.946  -6.735 2.050   -2.440  5.694   -4.310 LYS 5  HE3  polymer 1 1 180 ? ? ? 
PRD_001068 H52  H52  H 0 1 N N N -5.666  -9.108 1.971   -2.092  5.138   -6.602 LYS 5  HZ1  polymer 1 1 181 ? ? ? 
PRD_001068 H53  H53  H 0 1 N N N -6.532  -8.607 0.680   -1.650  3.877   -5.637 LYS 5  HZ2  polymer 1 1 182 ? ? ? 
PRD_001068 H54  H54  H 0 1 N N N -4.967  -9.034 0.497   -3.066  3.815   -6.477 LYS 5  HZ3  polymer 1 1 183 ? ? ? 
PRD_001068 H55  H55  H 0 1 N N N -4.542  -1.520 2.078   -7.408  2.295   -1.174 ARG 6  H    polymer 1 1 184 ? ? ? 
PRD_001068 H56  H56  H 0 1 N N N -7.159  -0.162 2.497   -7.005  1.086   1.527  ARG 6  HA   polymer 1 1 185 ? ? ? 
PRD_001068 H57  H57  H 0 1 N N N -6.598  -2.493 3.843   -9.660  1.578   0.103  ARG 6  HB2  polymer 1 1 186 ? ? ? 
PRD_001068 H58  H58  H 0 1 N N N -5.911  -1.264 4.958   -9.468  0.610   1.585  ARG 6  HB3  polymer 1 1 187 ? ? ? 
PRD_001068 H59  H59  H 0 1 N N N -8.009  -0.939 5.723   -8.533  2.587   2.754  ARG 6  HG2  polymer 1 1 188 ? ? ? 
PRD_001068 H60  H60  H 0 1 N N N -8.376  -0.172 4.141   -8.725  3.555   1.272  ARG 6  HG3  polymer 1 1 189 ? ? ? 
PRD_001068 H61  H61  H 0 1 N N N -8.733  -2.693 3.361   -11.171 3.149   1.324  ARG 6  HD2  polymer 1 1 190 ? ? ? 
PRD_001068 H62  H62  H 0 1 N N N -8.983  -2.974 5.117   -10.979 2.182   2.806  ARG 6  HD3  polymer 1 1 191 ? ? ? 
PRD_001068 H63  H63  H 0 1 N N N -10.536 -0.719 4.427   -9.818  4.719   3.243  ARG 6  HE   polymer 1 1 192 ? ? ? 
PRD_001068 H64  H64  H 0 0 N N N -12.103 -4.242 3.241   -12.920 3.231   2.673  ARG 6  HH11 polymer 1 1 193 ? ? ? 
PRD_001068 H65  H65  H 0 0 N N N -10.407 -4.131 3.575   -13.810 4.368   3.531  ARG 6  HH12 polymer 1 1 194 ? ? ? 
PRD_001068 H66  H66  H 0 0 N N N -13.458 -2.372 3.476   -12.741 6.141   4.549  ARG 6  HH21 polymer 1 1 195 ? ? ? 
PRD_001068 H67  H67  H 0 0 N N N -12.773 -0.866 3.985   -11.071 6.294   4.433  ARG 6  HH22 polymer 1 1 196 ? ? ? 
PRD_001068 H68  H68  H 0 1 N N N -6.247  1.784  2.043   -6.124  -0.989  1.091  ARG 7  H    polymer 1 1 197 ? ? ? 
PRD_001068 H69  H69  H 0 1 N N N -5.396  3.832  2.816   -7.612  -2.589  -0.885 ARG 7  HA   polymer 1 1 198 ? ? ? 
PRD_001068 H70  H70  H 0 1 N N N -5.303  2.331  5.153   -4.670  -1.865  -1.267 ARG 7  HB2  polymer 1 1 199 ? ? ? 
PRD_001068 H71  H71  H 0 1 N N N -3.579  2.758  4.883   -5.531  -3.117  -2.194 ARG 7  HB3  polymer 1 1 200 ? ? ? 
PRD_001068 H72  H72  H 0 1 N N N -4.988  5.127  4.303   -7.141  -1.413  -3.001 ARG 7  HG2  polymer 1 1 201 ? ? ? 
PRD_001068 H73  H73  H 0 1 N N N -5.826  4.448  5.740   -6.280  -0.160  -2.075 ARG 7  HG3  polymer 1 1 202 ? ? ? 
PRD_001068 H74  H74  H 0 1 N N N -3.134  4.075  6.365   -4.221  -0.611  -3.381 ARG 7  HD2  polymer 1 1 203 ? ? ? 
PRD_001068 H75  H75  H 0 1 N N N -3.125  5.648  5.499   -5.082  -1.863  -4.307 ARG 7  HD3  polymer 1 1 204 ? ? ? 
PRD_001068 H76  H76  H 0 1 N N N -5.281  5.532  7.424   -6.543  0.547   -4.496 ARG 7  HE   polymer 1 1 205 ? ? ? 
PRD_001068 H77  H77  H 0 0 N N N -1.682  6.910  8.622   -3.491  -0.844  -5.455 ARG 7  HH11 polymer 1 1 206 ? ? ? 
PRD_001068 H78  H78  H 0 0 N N N -1.799  5.972  7.170   -3.322  0.074   -6.852 ARG 7  HH12 polymer 1 1 207 ? ? ? 
PRD_001068 H79  H79  H 0 0 N N N -3.590  7.368  9.864   -6.293  1.816   -6.444 ARG 7  HH21 polymer 1 1 208 ? ? ? 
PRD_001068 H80  H80  H 0 0 N N N -5.129  6.772  9.338   -4.943  1.612   -7.425 ARG 7  HH22 polymer 1 1 209 ? ? ? 
PRD_001068 H81  H81  H 0 1 N N N -3.667  0.975  2.090   -6.242  -4.929  -1.054 TRP 8  H    polymer 1 1 210 ? ? ? 
PRD_001068 H82  H82  H 0 1 N N N -1.069  2.289  1.756   -5.078  -5.328  1.663  TRP 8  HA   polymer 1 1 211 ? ? ? 
PRD_001068 H83  H83  H 0 1 N N N -2.153  -0.486 1.272   -7.126  -7.109  0.270  TRP 8  HB2  polymer 1 1 212 ? ? ? 
PRD_001068 H84  H84  H 0 1 N N N -0.597  0.025  0.534   -6.257  -7.541  1.762  TRP 8  HB3  polymer 1 1 213 ? ? ? 
PRD_001068 H85  H85  H 0 1 N N N 0.986   1.347  2.751   -7.050  -6.379  3.998  TRP 8  HD1  polymer 1 1 214 ? ? ? 
PRD_001068 H86  H86  H 0 1 N N N 1.632   0.219  4.982   -9.030  -4.900  4.614  TRP 8  HE1  polymer 1 1 215 ? ? ? 
PRD_001068 H87  H87  H 0 1 N N N -2.628  -2.206 2.752   -8.694  -5.207  -0.692 TRP 8  HE3  polymer 1 1 216 ? ? ? 
PRD_001068 H88  H88  H 0 1 N N N 0.681   -1.949 6.544   -11.068 -3.400  3.251  TRP 8  HZ2  polymer 1 1 217 ? ? ? 
PRD_001068 H89  H89  H 0 1 N N N -2.696  -3.790 4.667   -10.641 -3.758  -0.978 TRP 8  HZ3  polymer 1 1 218 ? ? ? 
PRD_001068 H90  H90  H 0 1 N N N -1.118  -3.701 6.518   -11.823 -2.857  0.980  TRP 8  HH2  polymer 1 1 219 ? ? ? 
PRD_001068 H91  H91  H 0 1 N N N -0.066  2.680  -0.207  -2.899  -5.869  1.191  LYS 9  H    polymer 1 1 220 ? ? ? 
PRD_001068 H92  H92  H 0 1 N N N -1.817  2.677  -2.604  -2.527  -8.169  -0.588 LYS 9  HA   polymer 1 1 221 ? ? ? 
PRD_001068 H93  H93  H 0 1 N N N -1.590  4.958  -1.155  -1.479  -5.405  -1.355 LYS 9  HB2  polymer 1 1 222 ? ? ? 
PRD_001068 H94  H94  H 0 1 N N N -0.165  5.128  -2.236  -0.986  -6.926  -2.136 LYS 9  HB3  polymer 1 1 223 ? ? ? 
PRD_001068 H95  H95  H 0 1 N N N -1.589  5.883  -3.818  -3.343  -7.365  -2.771 LYS 9  HG2  polymer 1 1 224 ? ? ? 
PRD_001068 H96  H96  H 0 1 N N N -2.224  4.206  -3.926  -3.836  -5.843  -1.990 LYS 9  HG3  polymer 1 1 225 ? ? ? 
PRD_001068 H97  H97  H 0 1 N N N -3.281  5.957  -1.716  -2.371  -4.574  -3.536 LYS 9  HD2  polymer 1 1 226 ? ? ? 
PRD_001068 H98  H98  H 0 1 N N N -3.809  6.325  -3.393  -1.878  -6.096  -4.318 LYS 9  HD3  polymer 1 1 227 ? ? ? 
PRD_001068 H99  H99  H 0 1 N N N -3.882  3.435  -2.755  -4.235  -6.534  -4.952 LYS 9  HE2  polymer 1 1 228 ? ? ? 
PRD_001068 H100 H100 H 0 1 N N N -4.948  4.422  -1.698  -4.728  -5.012  -4.171 LYS 9  HE3  polymer 1 1 229 ? ? ? 
PRD_001068 H101 H101 H 0 1 N N N -6.055  3.741  -3.706  -4.405  -4.744  -6.518 LYS 9  HZ1  polymer 1 1 230 ? ? ? 
PRD_001068 H102 H102 H 0 1 N N N -5.901  5.367  -3.679  -3.300  -3.849  -5.686 LYS 9  HZ2  polymer 1 1 231 ? ? ? 
PRD_001068 H103 H103 H 0 1 N N N -4.932  4.470  -4.640  -2.844  -5.258  -6.409 LYS 9  HZ3  polymer 1 1 232 ? ? ? 
PRD_001068 H104 H104 H 0 1 N N N 0.301   4.374  -3.885  0.103   -8.499  -0.846 LYS 10 H    polymer 1 1 233 ? ? ? 
PRD_001068 H105 H105 H 0 1 N N N 1.733   2.338  -5.164  1.272   -7.484  1.716  LYS 10 HA   polymer 1 1 234 ? ? ? 
PRD_001068 H106 H106 H 0 1 N N N 1.484   5.062  -5.477  1.859   -10.068 0.200  LYS 10 HB2  polymer 1 1 235 ? ? ? 
PRD_001068 H107 H107 H 0 1 N N N 3.202   4.893  -4.981  2.756   -9.503  1.630  LYS 10 HB3  polymer 1 1 236 ? ? ? 
PRD_001068 H108 H108 H 0 1 N N N 3.626   4.382  -7.143  0.661   -9.532  2.956  LYS 10 HG2  polymer 1 1 237 ? ? ? 
PRD_001068 H109 H109 H 0 1 N N N 2.845   2.800  -6.802  -0.236  -10.096 1.527  LYS 10 HG3  polymer 1 1 238 ? ? ? 
PRD_001068 H110 H110 H 0 1 N N N 0.688   3.638  -7.565  1.182   -12.129 1.439  LYS 10 HD2  polymer 1 1 239 ? ? ? 
PRD_001068 H111 H111 H 0 1 N N N 1.349   5.298  -7.743  2.079   -11.564 2.869  LYS 10 HD3  polymer 1 1 240 ? ? ? 
PRD_001068 H112 H112 H 0 1 N N N 2.204   4.840  -9.789  -0.016  -11.593 4.195  LYS 10 HE2  polymer 1 1 241 ? ? ? 
PRD_001068 H113 H113 H 0 1 N N N 2.928   3.296  -9.224  -0.913  -12.157 2.766  LYS 10 HE3  polymer 1 1 242 ? ? ? 
PRD_001068 H114 H114 H 0 1 N N N 1.242   2.944  -10.882 0.484   -14.090 2.734  LYS 10 HZ1  polymer 1 1 243 ? ? ? 
PRD_001068 H115 H115 H 0 1 N N N 0.770   2.292  -9.461  1.314   -13.567 4.057  LYS 10 HZ2  polymer 1 1 244 ? ? ? 
PRD_001068 H116 H116 H 0 1 N N N 0.111   3.695  -9.974  -0.280  -13.963 4.189  LYS 10 HZ3  polymer 1 1 245 ? ? ? 
PRD_001068 H117 H117 H 0 1 N N N 4.296   2.506  -5.156  3.292   -6.288  1.479  ALA 11 H    polymer 1 1 246 ? ? ? 
PRD_001068 H118 H118 H 0 1 N N N 5.246   0.967  -3.093  4.448   -6.437  -1.246 ALA 11 HA   polymer 1 1 247 ? ? ? 
PRD_001068 H119 H119 H 0 1 N N N 7.511   1.794  -3.661  3.342   -3.850  -0.061 ALA 11 HB1  polymer 1 1 248 ? ? ? 
PRD_001068 H120 H120 H 0 1 N N N 6.531   1.472  -5.132  4.238   -3.991  -1.592 ALA 11 HB2  polymer 1 1 249 ? ? ? 
PRD_001068 H121 H121 H 0 1 N N N 6.781   3.160  -4.571  2.637   -4.751  -1.425 ALA 11 HB3  polymer 1 1 250 ? ? ? 
PRD_001068 H122 H122 H 0 1 N N N 5.506   1.170  -1.020  6.357   -4.589  -1.339 LYS 12 H    polymer 1 1 251 ? ? ? 
PRD_001068 H123 H123 H 0 1 N N N 6.184   3.775  0.163   7.627   -4.465  1.337  LYS 12 HA   polymer 1 1 252 ? ? ? 
PRD_001068 H124 H124 H 0 1 N N N 3.670   3.702  0.006   8.836   -5.802  -1.130 LYS 12 HB2  polymer 1 1 253 ? ? ? 
PRD_001068 H125 H125 H 0 1 N N N 3.706   2.294  1.122   9.732   -5.440  0.365  LYS 12 HB3  polymer 1 1 254 ? ? ? 
PRD_001068 H126 H126 H 0 1 N N N 5.239   4.762  1.922   8.159   -6.861  1.652  LYS 12 HG2  polymer 1 1 255 ? ? ? 
PRD_001068 H127 H127 H 0 1 N N N 3.446   4.824  2.009   7.264   -7.224  0.157  LYS 12 HG3  polymer 1 1 256 ? ? ? 
PRD_001068 H128 H128 H 0 1 N N N 3.465   2.746  3.394   9.305   -8.237  -0.820 LYS 12 HD2  polymer 1 1 257 ? ? ? 
PRD_001068 H129 H129 H 0 1 N N N 5.261   2.751  3.347   10.200  -7.875  0.674  LYS 12 HD3  polymer 1 1 258 ? ? ? 
PRD_001068 H130 H130 H 0 1 N N N 5.434   4.558  4.784   8.628   -9.296  1.961  LYS 12 HE2  polymer 1 1 259 ? ? ? 
PRD_001068 H131 H131 H 0 1 N N N 3.868   5.265  4.260   7.732   -9.658  0.466  LYS 12 HE3  polymer 1 1 260 ? ? ? 
PRD_001068 H132 H132 H 0 1 N N N 3.747   4.349  6.466   9.728   -10.617 -0.419 LYS 12 HZ1  polymer 1 1 261 ? ? ? 
PRD_001068 H133 H133 H 0 1 N N N 2.768   3.512  5.463   10.557  -10.282 0.965  LYS 12 HZ2  polymer 1 1 262 ? ? ? 
PRD_001068 H134 H134 H 0 1 N N N 4.192   2.869  5.939   9.314   -11.363 0.991  LYS 12 HZ3  polymer 1 1 263 ? ? ? 
PRD_001068 H135 H135 H 0 1 N N N 8.242   1.719  3.310   9.983   -1.495  -1.416 DPR 13 HA   polymer 1 1 264 ? ? ? 
PRD_001068 H136 H136 H 0 1 N N N 9.807   3.380  2.829   12.130  -1.947  -0.741 DPR 13 HB2  polymer 1 1 265 ? ? ? 
PRD_001068 H137 H137 H 0 1 N N N 10.822  1.952  2.433   11.898  -0.625  0.442  DPR 13 HB3  polymer 1 1 266 ? ? ? 
PRD_001068 H138 H138 H 0 1 N N N 10.477  3.874  0.580   12.127  -3.493  0.945  DPR 13 HG2  polymer 1 1 267 ? ? ? 
PRD_001068 H139 H139 H 0 1 N N N 10.396  2.151  0.079   11.978  -2.166  2.140  DPR 13 HG3  polymer 1 1 268 ? ? ? 
PRD_001068 H140 H140 H 0 1 N N N 8.265   2.785  -0.694  9.684   -2.436  2.312  DPR 13 HD2  polymer 1 1 269 ? ? ? 
PRD_001068 H141 H141 H 0 1 N N N 8.141   4.148  0.470   10.014  -4.063  1.666  DPR 13 HD3  polymer 1 1 270 ? ? ? 
PRD_001068 H142 H142 H 0 1 N N N 10.010  -2.293 3.153   9.336   2.221   1.408  PRO 14 HA   polymer 1 1 271 ? ? ? 
PRD_001068 H143 H143 H 0 1 N N N 7.968   -3.674 4.420   10.477  4.220   -0.127 PRO 14 HB2  polymer 1 1 272 ? ? ? 
PRD_001068 H144 H144 H 0 1 N N N 9.120   -2.568 5.243   11.400  3.234   1.051  PRO 14 HB3  polymer 1 1 273 ? ? ? 
PRD_001068 H145 H145 H 0 1 N N N 6.264   -2.010 4.292   11.528  3.196   -1.895 PRO 14 HG2  polymer 1 1 274 ? ? ? 
PRD_001068 H146 H146 H 0 1 N N N 7.041   -1.573 5.852   12.614  2.406   -0.713 PRO 14 HG3  polymer 1 1 275 ? ? ? 
PRD_001068 H147 H147 H 0 1 N N N 8.191   0.270  4.909   11.643  0.420   -1.287 PRO 14 HD2  polymer 1 1 276 ? ? ? 
PRD_001068 H148 H148 H 0 1 N N N 6.802   0.234  3.771   10.380  1.248   -2.242 PRO 14 HD3  polymer 1 1 277 ? ? ? 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
PRD_001068 N1  C1   SING N N 1   
PRD_001068 N1  H1   SING N N 2   
PRD_001068 C1  C2   SING N N 3   
PRD_001068 C1  C3   SING N N 4   
PRD_001068 C1  H2   SING N N 5   
PRD_001068 C2  O1   DOUB N N 6   
PRD_001068 C3  O2   SING N N 7   
PRD_001068 C3  C4   SING N N 8   
PRD_001068 C3  H3   SING N N 9   
PRD_001068 O2  H4   SING N N 10  
PRD_001068 C4  H5   SING N N 11  
PRD_001068 C4  H6   SING N N 12  
PRD_001068 C4  H7   SING N N 13  
PRD_001068 N2  C5   SING N N 14  
PRD_001068 N2  H8   SING N N 15  
PRD_001068 C5  C6   SING N N 16  
PRD_001068 C5  C7   SING N N 17  
PRD_001068 C5  H9   SING N N 18  
PRD_001068 C6  O3   DOUB N N 19  
PRD_001068 C7  C8   SING N N 20  
PRD_001068 C7  H10  SING N N 21  
PRD_001068 C7  H11  SING N N 22  
PRD_001068 C8  C9   DOUB Y N 23  
PRD_001068 C8  C10  SING Y N 24  
PRD_001068 C9  N3   SING Y N 25  
PRD_001068 C9  H12  SING N N 26  
PRD_001068 C10 C11  DOUB Y N 27  
PRD_001068 C10 C12  SING Y N 28  
PRD_001068 N3  C11  SING Y N 29  
PRD_001068 N3  H13  SING N N 30  
PRD_001068 C11 C13  SING Y N 31  
PRD_001068 C12 C14  DOUB Y N 32  
PRD_001068 C12 H14  SING N N 33  
PRD_001068 C13 C15  DOUB Y N 34  
PRD_001068 C13 H15  SING N N 35  
PRD_001068 C14 C15  SING Y N 36  
PRD_001068 C14 H16  SING N N 37  
PRD_001068 C15 H17  SING N N 38  
PRD_001068 N4  C16  SING N N 39  
PRD_001068 N4  H18  SING N N 40  
PRD_001068 C16 C17  SING N N 41  
PRD_001068 C16 C18  SING N N 42  
PRD_001068 C16 H19  SING N N 43  
PRD_001068 C17 O4   DOUB N N 44  
PRD_001068 C18 C19  SING N N 45  
PRD_001068 C18 H20  SING N N 46  
PRD_001068 C18 H21  SING N N 47  
PRD_001068 C19 C20  SING N N 48  
PRD_001068 C19 C21  SING N N 49  
PRD_001068 C19 H22  SING N N 50  
PRD_001068 C20 H23  SING N N 51  
PRD_001068 C20 H24  SING N N 52  
PRD_001068 C20 H25  SING N N 53  
PRD_001068 C21 H26  SING N N 54  
PRD_001068 C21 H27  SING N N 55  
PRD_001068 C21 H28  SING N N 56  
PRD_001068 N5  C22  SING N N 57  
PRD_001068 N5  H29  SING N N 58  
PRD_001068 C22 C23  SING N N 59  
PRD_001068 C22 C24  SING N N 60  
PRD_001068 C22 H30  SING N N 61  
PRD_001068 C23 O5   DOUB N N 62  
PRD_001068 C24 C25  SING N N 63  
PRD_001068 C24 H31  SING N N 64  
PRD_001068 C24 H32  SING N N 65  
PRD_001068 C25 C26  SING N N 66  
PRD_001068 C25 H33  SING N N 67  
PRD_001068 C25 H34  SING N N 68  
PRD_001068 C26 C27  SING N N 69  
PRD_001068 C26 H35  SING N N 70  
PRD_001068 C26 H36  SING N N 71  
PRD_001068 C27 N6   SING N N 72  
PRD_001068 C27 H37  SING N N 73  
PRD_001068 C27 H38  SING N N 74  
PRD_001068 N6  H39  SING N N 75  
PRD_001068 N6  H40  SING N N 76  
PRD_001068 N6  H41  SING N N 77  
PRD_001068 N7  C28  SING N N 78  
PRD_001068 N7  H42  SING N N 79  
PRD_001068 C28 C29  SING N N 80  
PRD_001068 C28 C30  SING N N 81  
PRD_001068 C28 H43  SING N N 82  
PRD_001068 C29 O6   DOUB N N 83  
PRD_001068 C30 C31  SING N N 84  
PRD_001068 C30 H44  SING N N 85  
PRD_001068 C30 H45  SING N N 86  
PRD_001068 C31 C32  SING N N 87  
PRD_001068 C31 H46  SING N N 88  
PRD_001068 C31 H47  SING N N 89  
PRD_001068 C32 C33  SING N N 90  
PRD_001068 C32 H48  SING N N 91  
PRD_001068 C32 H49  SING N N 92  
PRD_001068 C33 N8   SING N N 93  
PRD_001068 C33 H50  SING N N 94  
PRD_001068 C33 H51  SING N N 95  
PRD_001068 N8  H52  SING N N 96  
PRD_001068 N8  H53  SING N N 97  
PRD_001068 N8  H54  SING N N 98  
PRD_001068 N9  C34  SING N N 99  
PRD_001068 N9  H55  SING N N 100 
PRD_001068 C34 C35  SING N N 101 
PRD_001068 C34 C36  SING N N 102 
PRD_001068 C34 H56  SING N N 103 
PRD_001068 C35 O7   DOUB N N 104 
PRD_001068 C36 C37  SING N N 105 
PRD_001068 C36 H57  SING N N 106 
PRD_001068 C36 H58  SING N N 107 
PRD_001068 C37 C38  SING N N 108 
PRD_001068 C37 H59  SING N N 109 
PRD_001068 C37 H60  SING N N 110 
PRD_001068 C38 N10  SING N N 111 
PRD_001068 C38 H61  SING N N 112 
PRD_001068 C38 H62  SING N N 113 
PRD_001068 N10 C39  SING N N 114 
PRD_001068 N10 H63  SING N N 115 
PRD_001068 C39 N11  SING N N 116 
PRD_001068 C39 N12  DOUB N N 117 
PRD_001068 N11 H64  SING N N 118 
PRD_001068 N11 H65  SING N N 119 
PRD_001068 N12 H66  SING N N 120 
PRD_001068 N12 H67  SING N N 121 
PRD_001068 N13 C40  SING N N 122 
PRD_001068 N13 H68  SING N N 123 
PRD_001068 C40 C41  SING N N 124 
PRD_001068 C40 C42  SING N N 125 
PRD_001068 C40 H69  SING N N 126 
PRD_001068 C41 O8   DOUB N N 127 
PRD_001068 C42 C43  SING N N 128 
PRD_001068 C42 H70  SING N N 129 
PRD_001068 C42 H71  SING N N 130 
PRD_001068 C43 C44  SING N N 131 
PRD_001068 C43 H72  SING N N 132 
PRD_001068 C43 H73  SING N N 133 
PRD_001068 C44 N14  SING N N 134 
PRD_001068 C44 H74  SING N N 135 
PRD_001068 C44 H75  SING N N 136 
PRD_001068 N14 C45  SING N N 137 
PRD_001068 N14 H76  SING N N 138 
PRD_001068 C45 N15  SING N N 139 
PRD_001068 C45 N16  DOUB N N 140 
PRD_001068 N15 H77  SING N N 141 
PRD_001068 N15 H78  SING N N 142 
PRD_001068 N16 H79  SING N N 143 
PRD_001068 N16 H80  SING N N 144 
PRD_001068 N17 C46  SING N N 145 
PRD_001068 N17 H81  SING N N 146 
PRD_001068 C46 C47  SING N N 147 
PRD_001068 C46 C48  SING N N 148 
PRD_001068 C46 H82  SING N N 149 
PRD_001068 C47 O9   DOUB N N 150 
PRD_001068 C48 C49  SING N N 151 
PRD_001068 C48 H83  SING N N 152 
PRD_001068 C48 H84  SING N N 153 
PRD_001068 C49 C50  DOUB Y N 154 
PRD_001068 C49 C51  SING Y N 155 
PRD_001068 C50 N18  SING Y N 156 
PRD_001068 C50 H85  SING N N 157 
PRD_001068 C51 C52  DOUB Y N 158 
PRD_001068 C51 C53  SING Y N 159 
PRD_001068 N18 C52  SING Y N 160 
PRD_001068 N18 H86  SING N N 161 
PRD_001068 C52 C54  SING Y N 162 
PRD_001068 C53 C55  DOUB Y N 163 
PRD_001068 C53 H87  SING N N 164 
PRD_001068 C54 C56  DOUB Y N 165 
PRD_001068 C54 H88  SING N N 166 
PRD_001068 C55 C56  SING Y N 167 
PRD_001068 C55 H89  SING N N 168 
PRD_001068 C56 H90  SING N N 169 
PRD_001068 N19 C57  SING N N 170 
PRD_001068 N19 H91  SING N N 171 
PRD_001068 C57 C58  SING N N 172 
PRD_001068 C57 C59  SING N N 173 
PRD_001068 C57 H92  SING N N 174 
PRD_001068 C58 O10  DOUB N N 175 
PRD_001068 C59 C60  SING N N 176 
PRD_001068 C59 H93  SING N N 177 
PRD_001068 C59 H94  SING N N 178 
PRD_001068 C60 C61  SING N N 179 
PRD_001068 C60 H95  SING N N 180 
PRD_001068 C60 H96  SING N N 181 
PRD_001068 C61 C62  SING N N 182 
PRD_001068 C61 H97  SING N N 183 
PRD_001068 C61 H98  SING N N 184 
PRD_001068 C62 N20  SING N N 185 
PRD_001068 C62 H99  SING N N 186 
PRD_001068 C62 H100 SING N N 187 
PRD_001068 N20 H101 SING N N 188 
PRD_001068 N20 H102 SING N N 189 
PRD_001068 N20 H103 SING N N 190 
PRD_001068 N21 C63  SING N N 191 
PRD_001068 N21 H104 SING N N 192 
PRD_001068 C63 C64  SING N N 193 
PRD_001068 C63 C65  SING N N 194 
PRD_001068 C63 H105 SING N N 195 
PRD_001068 C64 O11  DOUB N N 196 
PRD_001068 C65 C66  SING N N 197 
PRD_001068 C65 H106 SING N N 198 
PRD_001068 C65 H107 SING N N 199 
PRD_001068 C66 C67  SING N N 200 
PRD_001068 C66 H108 SING N N 201 
PRD_001068 C66 H109 SING N N 202 
PRD_001068 C67 C68  SING N N 203 
PRD_001068 C67 H110 SING N N 204 
PRD_001068 C67 H111 SING N N 205 
PRD_001068 C68 N22  SING N N 206 
PRD_001068 C68 H112 SING N N 207 
PRD_001068 C68 H113 SING N N 208 
PRD_001068 N22 H114 SING N N 209 
PRD_001068 N22 H115 SING N N 210 
PRD_001068 N22 H116 SING N N 211 
PRD_001068 N23 C69  SING N N 212 
PRD_001068 N23 H117 SING N N 213 
PRD_001068 C69 C70  SING N N 214 
PRD_001068 C69 C71  SING N N 215 
PRD_001068 C69 H118 SING N N 216 
PRD_001068 C70 O12  DOUB N N 217 
PRD_001068 C71 H119 SING N N 218 
PRD_001068 C71 H120 SING N N 219 
PRD_001068 C71 H121 SING N N 220 
PRD_001068 N24 C72  SING N N 221 
PRD_001068 N24 H122 SING N N 222 
PRD_001068 C72 C73  SING N N 223 
PRD_001068 C72 C74  SING N N 224 
PRD_001068 C72 H123 SING N N 225 
PRD_001068 C73 O13  DOUB N N 226 
PRD_001068 C74 C75  SING N N 227 
PRD_001068 C74 H124 SING N N 228 
PRD_001068 C74 H125 SING N N 229 
PRD_001068 C75 C76  SING N N 230 
PRD_001068 C75 H126 SING N N 231 
PRD_001068 C75 H127 SING N N 232 
PRD_001068 C76 C77  SING N N 233 
PRD_001068 C76 H128 SING N N 234 
PRD_001068 C76 H129 SING N N 235 
PRD_001068 C77 N25  SING N N 236 
PRD_001068 C77 H130 SING N N 237 
PRD_001068 C77 H131 SING N N 238 
PRD_001068 N25 H132 SING N N 239 
PRD_001068 N25 H133 SING N N 240 
PRD_001068 N25 H134 SING N N 241 
PRD_001068 N26 C78  SING N N 242 
PRD_001068 N26 C81  SING N N 243 
PRD_001068 C78 C79  SING N N 244 
PRD_001068 C78 C82  SING N N 245 
PRD_001068 C78 H135 SING N N 246 
PRD_001068 C79 C80  SING N N 247 
PRD_001068 C79 H136 SING N N 248 
PRD_001068 C79 H137 SING N N 249 
PRD_001068 C80 C81  SING N N 250 
PRD_001068 C80 H138 SING N N 251 
PRD_001068 C80 H139 SING N N 252 
PRD_001068 C81 H140 SING N N 253 
PRD_001068 C81 H141 SING N N 254 
PRD_001068 C82 O14  DOUB N N 255 
PRD_001068 N27 C83  SING N N 256 
PRD_001068 N27 C87  SING N N 257 
PRD_001068 C83 C84  SING N N 258 
PRD_001068 C83 C85  SING N N 259 
PRD_001068 C83 H142 SING N N 260 
PRD_001068 C84 O15  DOUB N N 261 
PRD_001068 C85 C86  SING N N 262 
PRD_001068 C85 H143 SING N N 263 
PRD_001068 C85 H144 SING N N 264 
PRD_001068 C86 C87  SING N N 265 
PRD_001068 C86 H145 SING N N 266 
PRD_001068 C86 H146 SING N N 267 
PRD_001068 C87 H147 SING N N 268 
PRD_001068 C87 H148 SING N N 269 
PRD_001068 N1  C84  SING N N 270 
PRD_001068 C2  N2   SING N N 271 
PRD_001068 C6  N4   SING N N 272 
PRD_001068 C17 N5   SING N N 273 
PRD_001068 C23 N7   SING N N 274 
PRD_001068 C29 N9   SING N N 275 
PRD_001068 C35 N13  SING N N 276 
PRD_001068 C41 N17  SING N N 277 
PRD_001068 C47 N19  SING N N 278 
PRD_001068 C58 N21  SING N N 279 
PRD_001068 C64 N23  SING N N 280 
PRD_001068 C70 N24  SING N N 281 
PRD_001068 C73 N26  SING N N 282 
PRD_001068 C82 N27  SING N N 283 
# 
loop_
_pdbx_chem_comp_descriptor.comp_id 
_pdbx_chem_comp_descriptor.type 
_pdbx_chem_comp_descriptor.program 
_pdbx_chem_comp_descriptor.program_version 
_pdbx_chem_comp_descriptor.descriptor 
PRD_001068 InChI            InChI                1.03  "InChI=1S/C87H141N27O15/c1-50(2)45-66-79(123)106-61(29-11-16-38-90)76(120)103-60(28-10-15-37-89)74(118)104-63(32-19-41-97-86(93)94)77(121)105-64(33-20-42-98-87(95)96)78(122)110-67(46-53-48-99-57-25-7-5-23-55(53)57)80(124)107-62(30-12-17-39-91)75(119)102-59(27-9-14-36-88)73(117)101-51(3)72(116)108-65(31-13-18-40-92)84(128)114-44-22-35-70(114)85(129)113-43-21-34-69(113)82(126)112-71(52(4)115)83(127)111-68(81(125)109-66)47-54-49-100-58-26-8-6-24-56(54)58/h5-8,23-26,48-52,59-71,99-100,115H,9-22,27-47,88-92H2,1-4H3,(H,101,117)(H,102,119)(H,103,120)(H,104,118)(H,105,121)(H,106,123)(H,107,124)(H,108,116)(H,109,125)(H,110,122)(H,111,127)(H,112,126)(H4,93,94,97)(H4,95,96,98)/p+7/t51-,52+,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70+,71-/m0/s1" 
PRD_001068 InChIKey         InChI                1.03  NGDPXIDFYKFHOM-PWANQUNESA-U                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
PRD_001068 SMILES_CANONICAL CACTVS               3.370 "CC(C)C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@H]5CCCN5C(=O)[C@H](CCCC[NH3+])NC(=O)[C@H](C)NC(=O)[C@H](CCCC[NH3+])NC(=O)[C@H](CCCC[NH3+])NC(=O)[C@H](Cc6c[nH]c7ccccc67)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](CCCC[NH3+])NC(=O)[C@H](CCCC[NH3+])NC1=O)[C@@H](C)O"                                                                                                                                                                                                                                                                                                                                                                                                                                         
PRD_001068 SMILES           CACTVS               3.370 "CC(C)C[CH]1NC(=O)[CH](Cc2c[nH]c3ccccc23)NC(=O)[CH](NC(=O)[CH]4CCCN4C(=O)[CH]5CCCN5C(=O)[CH](CCCC[NH3+])NC(=O)[CH](C)NC(=O)[CH](CCCC[NH3+])NC(=O)[CH](CCCC[NH3+])NC(=O)[CH](Cc6c[nH]c7ccccc67)NC(=O)[CH](CCCNC(N)=[NH2+])NC(=O)[CH](CCCNC(N)=[NH2+])NC(=O)[CH](CCCC[NH3+])NC(=O)[CH](CCCC[NH3+])NC1=O)[CH](C)O"                                                                                                                                                                                                                                                                                                                                                                                                                                                            
PRD_001068 SMILES_CANONICAL "OpenEye OEToolkits" 1.7.6 "C[C@H]1C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCC[NH3+])CCCC[NH3+])Cc4c[nH]c5c4cccc5)CCCNC(=[NH2+])N)CCCNC(=[NH2+])N)CCCC[NH3+])CCCC[NH3+])CC(C)C)Cc6c[nH]c7c6cccc7)[C@@H](C)O)CCCC[NH3+]"                                                                                                                                                                                                                                                                                                                                                                                                                                         
PRD_001068 SMILES           "OpenEye OEToolkits" 1.7.6 "CC1C(=O)NC(C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCC[NH3+])CCCC[NH3+])Cc4c[nH]c5c4cccc5)CCCNC(=[NH2+])N)CCCNC(=[NH2+])N)CCCC[NH3+])CCCC[NH3+])CC(C)C)Cc6c[nH]c7c6cccc7)C(C)O)CCCC[NH3+]"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
# 
