data_A1APF
# 
_chem_comp.id                                    A1APF 
_chem_comp.name                                  "(5P)-2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-{(1R,2S)-2-[(4'-{2-[4-(2-oxoethyl)piperazin-1-yl]propan-2-yl}[1,1'-biphenyl]-4-yl)methoxy]cyclopentyl}pyridine-3-carboxamide" 
_chem_comp.type                                  non-polymer 
_chem_comp.pdbx_type                             HETAIN 
_chem_comp.formula                               "C37 H45 N7 O3" 
_chem_comp.mon_nstd_parent_comp_id               ? 
_chem_comp.pdbx_synonyms                         ? 
_chem_comp.pdbx_formal_charge                    0 
_chem_comp.pdbx_initial_date                     2024-04-22 
_chem_comp.pdbx_modified_date                    2024-10-04 
_chem_comp.pdbx_ambiguous_flag                   N 
_chem_comp.pdbx_release_status                   REL 
_chem_comp.pdbx_replaced_by                      ? 
_chem_comp.pdbx_replaces                         ? 
_chem_comp.formula_weight                        635.798 
_chem_comp.one_letter_code                       ? 
_chem_comp.three_letter_code                     A1APF 
_chem_comp.pdbx_model_coordinates_details        ? 
_chem_comp.pdbx_model_coordinates_missing_flag   N 
_chem_comp.pdbx_ideal_coordinates_details        Corina 
_chem_comp.pdbx_ideal_coordinates_missing_flag   N 
_chem_comp.pdbx_model_coordinates_db_code        9BHI 
_chem_comp.pdbx_subcomponent_list                ? 
_chem_comp.pdbx_processing_site                  RCSB 
_chem_comp.pdbx_pcm                              ? 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.alt_atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.charge 
_chem_comp_atom.pdbx_align 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_leaving_atom_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_n_terminal_atom_flag 
_chem_comp_atom.pdbx_backbone_atom_flag 
_chem_comp_atom.pdbx_c_terminal_atom_flag 
_chem_comp_atom.model_Cartn_x 
_chem_comp_atom.model_Cartn_y 
_chem_comp_atom.model_Cartn_z 
_chem_comp_atom.pdbx_model_Cartn_x_ideal 
_chem_comp_atom.pdbx_model_Cartn_y_ideal 
_chem_comp_atom.pdbx_model_Cartn_z_ideal 
_chem_comp_atom.pdbx_component_atom_id 
_chem_comp_atom.pdbx_component_comp_id 
_chem_comp_atom.pdbx_ordinal 
A1APF N1   N1  N 0 1 Y N N N N N -34.386 -10.944 -9.309  -7.981 -3.602 2.696  N1   A1APF 1  
A1APF N3   N2  N 0 1 N N N N N N -40.056 -8.641  -4.618  -6.372 -0.245 -4.078 N3   A1APF 2  
A1APF C4   C1  C 0 1 Y N N N N N -37.297 -10.396 -7.099  -7.325 -2.283 -0.626 C4   A1APF 3  
A1APF C5   C2  C 0 1 Y N N N N N -37.725 -9.082  -7.222  -7.526 -2.817 -1.897 C5   A1APF 4  
A1APF C6   C3  C 0 1 Y N N N N N -39.184 -9.251  -5.428  -6.688 -0.920 -2.913 C6   A1APF 5  
A1APF C7   C4  C 0 1 Y N N N N N -38.806 -10.610 -5.240  -6.454 -0.309 -1.669 C7   A1APF 6  
A1APF C8   C5  C 0 1 Y N N N N N -37.862 -11.180 -6.097  -6.780 -1.006 -0.502 C8   A1APF 7  
A1APF C10  C6  C 0 1 N N S N N N -39.029 -13.100 -2.367  -4.977 2.922  -0.328 C10  A1APF 8  
A1APF C13  C7  C 0 1 N N N N N N -37.578 -13.003 -0.422  -4.446 4.544  1.415  C13  A1APF 9  
A1APF C15  C8  C 0 1 N N N N N N -40.960 -11.465 -0.609  -2.065 2.352  1.854  C15  A1APF 10 
A1APF C17  C9  C 0 1 Y N N N N N -42.707 -13.128 0.086   0.277  3.222  1.709  C17  A1APF 11 
A1APF C20  C10 C 0 1 Y N N N N N -43.990 -11.249 1.642   1.158  0.835  0.608  C20  A1APF 12 
A1APF C21  C11 C 0 1 Y N N N N N -42.846 -10.910 0.946   -0.173 0.997  0.935  C21  A1APF 13 
A1APF C22  C12 C 0 1 Y N N N N N -45.776 -12.874 2.270   3.487  1.714  0.463  C22  A1APF 14 
A1APF C24  C13 C 0 1 Y N N N N N -47.368 -14.506 3.061   5.266  0.372  -0.430 C24  A1APF 15 
A1APF C26  C14 C 0 1 Y N N N N N -47.798 -12.186 3.394   5.713  2.603  0.330  C26  A1APF 16 
A1APF C28  C15 C 0 1 N N N N N N -49.523 -13.857 4.235   7.604  1.249  -0.592 C28  A1APF 17 
A1APF N    N3  N 0 1 Y N N N N N -34.709 -12.197 -8.910  -8.422 -4.660 1.892  N    A1APF 18 
A1APF C    C16 C 0 1 N N N N N N -33.969 -13.342 -9.429  -8.984 -5.926 2.369  C    A1APF 19 
A1APF O    O1  O 0 1 N N N N N N -40.547 -11.255 -3.767  -5.683 1.680  -2.615 O    A1APF 20 
A1APF C1   C17 C 0 1 Y N N N N N -35.764 -12.208 -8.086  -8.239 -4.313 0.601  C1   A1APF 21 
A1APF C11  C18 C 0 1 N N N N N N -38.330 -14.457 -2.208  -6.098 3.975  -0.288 C11  A1APF 22 
A1APF C12  C19 C 0 1 N N N N N N -37.797 -14.461 -0.784  -5.937 4.740  1.043  C12  A1APF 23 
A1APF C14  C20 C 0 1 N N S N N N -38.767 -12.301 -1.070  -4.173 3.083  0.979  C14  A1APF 24 
A1APF C16  C21 C 0 1 Y N N N N N -42.191 -11.841 0.156   -0.613 2.185  1.489  C16  A1APF 25 
A1APF C18  C22 C 0 1 Y N N N N N -43.851 -13.471 0.784   1.608  3.075  1.377  C18  A1APF 26 
A1APF C19  C23 C 0 1 Y N N N N N -44.515 -12.535 1.574   2.057  1.878  0.823  C19  A1APF 27 
A1APF C2   C24 C 0 1 Y N N N N N -36.177 -10.904 -7.923  -7.694 -3.062 0.584  C2   A1APF 28 
A1APF C23  C25 C 0 1 Y N N N N N -46.178 -14.195 2.430   3.936  0.517  -0.091 C23  A1APF 29 
A1APF C25  C26 C 0 1 Y N N N N N -48.199 -13.506 3.555   6.153  1.412  -0.220 C25  A1APF 30 
A1APF C27  C27 C 0 1 Y N N N N N -46.608 -11.876 2.764   4.385  2.759  0.672  C27  A1APF 31 
A1APF C29  C28 C 0 1 N N N N N N -50.384 -14.329 3.131   7.845  1.848  -1.980 C29  A1APF 32 
A1APF C3   C29 C 0 1 Y N N N N N -35.276 -10.169 -8.712  -7.545 -2.645 1.920  C3   A1APF 33 
A1APF C30  C30 C 0 1 N N N N N N -50.164 -12.732 4.983   8.479  1.971  0.434  C30  A1APF 34 
A1APF C31  C31 C 0 1 N N N N N N -50.421 -15.847 5.608   7.846  -0.762 0.736  C31  A1APF 35 
A1APF C32  C32 C 0 1 N N N N N N -49.991 -17.065 6.401   8.133  -2.263 0.662  C32  A1APF 36 
A1APF C33  C33 C 0 1 N N N N N N -48.926 -17.784 8.511   9.816  -3.905 0.081  C33  A1APF 37 
A1APF C34  C34 C 0 1 N N N N N N -47.893 -17.505 9.526   11.273 -4.068 -0.269 C34  A1APF 38 
A1APF C35  C35 C 0 1 N N N N N N -48.005 -15.839 7.239   9.574  -1.895 -1.248 C35  A1APF 39 
A1APF C36  C36 C 0 1 N N N N N N -48.404 -14.617 6.428   9.287  -0.393 -1.174 C36  A1APF 40 
A1APF C9   C37 C 0 1 N N N N N N -39.382 -11.420 -4.113  -5.873 1.045  -1.596 C9   A1APF 41 
A1APF N2   N4  N 0 1 Y N N N N N -38.631 -8.514  -6.418  -7.208 -2.136 -2.979 N2   A1APF 42 
A1APF N4   N5  N 0 1 N N N N N N -38.604 -12.353 -3.548  -5.553 1.577  -0.400 N4   A1APF 43 
A1APF N5   N6  N 0 1 N N N N N N -49.228 -15.014 5.228   7.947  -0.180 -0.610 N5   A1APF 44 
A1APF N6   N7  N 0 1 N N N N N N -49.241 -16.610 7.621   9.473  -2.476 0.098  N6   A1APF 45 
A1APF O1   O2  O 0 1 N N N N N N -39.923 -12.363 -0.233  -2.779 2.886  0.737  O1   A1APF 46 
A1APF O2   O3  O 0 1 N N N N N N -47.273 -18.334 10.121  12.004 -4.689 0.464  O2   A1APF 47 
A1APF H33  H1  H 0 1 N N N N N N -40.159 -7.686  -4.897  -6.344 0.724  -4.085 H33  A1APF 48 
A1APF H32  H2  H 0 1 N N N N N N -40.942 -9.102  -4.674  -6.178 -0.742 -4.889 H32  A1APF 49 
A1APF H51  H3  H 0 1 N N N N N N -37.302 -8.482  -8.014  -7.949 -3.806 -1.997 H51  A1APF 50 
A1APF H81  H4  H 0 1 N N N N N N -37.574 -12.215 -5.984  -6.613 -0.566 0.471  H81  A1APF 51 
A1APF H101 H5  H 0 0 N N N N N N -40.111 -13.284 -2.434  -4.330 3.098  -1.188 H101 A1APF 52 
A1APF H131 H6  H 0 0 N N N N N N -37.583 -12.862 0.669   -3.815 5.238  0.859  H131 A1APF 53 
A1APF H132 H7  H 0 0 N N N N N N -36.628 -12.632 -0.835  -4.294 4.662  2.488  H132 A1APF 54 
A1APF H151 H8  H 0 0 N N N N N N -41.151 -11.546 -1.689  -2.485 1.383  2.125  H151 A1APF 55 
A1APF H152 H9  H 0 0 N N N N N N -40.668 -10.433 -0.365  -2.151 3.034  2.700  H152 A1APF 56 
A1APF H171 H10 H 0 0 N N N N N N -42.209 -13.870 -0.521  -0.072 4.149  2.139  H171 A1APF 57 
A1APF H201 H11 H 0 0 N N N N N N -44.484 -10.504 2.248   1.500  -0.093 0.175  H201 A1APF 58 
A1APF H211 H12 H 0 0 N N N N N N -42.457 -9.905  1.019   -0.873 0.194  0.757  H211 A1APF 59 
A1APF H241 H13 H 0 0 N N N N N N -47.657 -15.541 3.172   5.615  -0.555 -0.860 H241 A1APF 60 
A1APF H261 H14 H 0 0 N N N N N N -48.426 -11.390 3.767   6.410  3.412  0.492  H261 A1APF 61 
A1APF HC3  H15 H 0 1 N N N N N N -33.193 -12.992 -10.126 -8.182 -6.650 2.511  HC3  A1APF 62 
A1APF HC1  H16 H 0 1 N N N N N N -33.497 -13.882 -8.595  -9.496 -5.761 3.317  HC1  A1APF 63 
A1APF HC2  H17 H 0 1 N N N N N N -34.660 -14.016 -9.957  -9.693 -6.308 1.635  HC2  A1APF 64 
A1APF H11  H18 H 0 1 N N N N N N -36.210 -13.080 -7.632  -8.480 -4.915 -0.262 H11  A1APF 65 
A1APF H111 H19 H 0 0 N N N N N N -39.045 -15.280 -2.355  -5.995 4.662  -1.128 H111 A1APF 66 
A1APF H112 H20 H 0 0 N N N N N N -37.505 -14.554 -2.930  -7.071 3.486  -0.322 H112 A1APF 67 
A1APF H121 H21 H 0 0 N N N N N N -38.528 -14.920 -0.102  -6.581 4.310  1.810  H121 A1APF 68 
A1APF H122 H22 H 0 0 N N N N N N -36.849 -15.016 -0.731  -6.160 5.797  0.904  H122 A1APF 69 
A1APF H141 H23 H 0 0 N N N N N N -38.504 -11.262 -1.318  -4.533 2.386  1.736  H141 A1APF 70 
A1APF H181 H24 H 0 0 N N N N N N -44.235 -14.478 0.716   2.301  3.886  1.545  H181 A1APF 71 
A1APF H231 H25 H 0 0 N N N N N N -45.551 -14.991 2.056   3.244  -0.296 -0.256 H231 A1APF 72 
A1APF H271 H26 H 0 0 N N N N N N -46.319 -10.841 2.654   4.042  3.689  1.101  H271 A1APF 73 
A1APF H292 H27 H 0 0 N N N N N N -51.371 -14.608 3.529   8.895  1.729  -2.249 H292 A1APF 74 
A1APF H293 H28 H 0 0 N N N N N N -50.501 -13.526 2.389   7.222  1.333  -2.711 H293 A1APF 75 
A1APF H291 H29 H 0 0 N N N N N N -49.920 -15.205 2.653   7.591  2.908  -1.967 H291 A1APF 76 
A1APF H31  H30 H 0 1 N N N N N N -35.307 -9.095  -8.819  -7.142 -1.698 2.247  H31  A1APF 77 
A1APF H302 H31 H 0 0 N N N N N N -51.105 -13.080 5.434   8.224  3.031  0.447  H302 A1APF 78 
A1APF H301 H32 H 0 0 N N N N N N -49.484 -12.384 5.775   8.307  1.544  1.422  H301 A1APF 79 
A1APF H303 H33 H 0 0 N N N N N N -50.374 -11.904 4.290   9.528  1.852  0.165  H303 A1APF 80 
A1APF H312 H34 H 0 0 N N N N N N -50.939 -16.175 4.694   6.842  -0.602 1.127  H312 A1APF 81 
A1APF H311 H35 H 0 0 N N N N N N -51.105 -15.241 6.220   8.573  -0.285 1.394  H311 A1APF 82 
A1APF H321 H36 H 0 0 N N N N N N -50.878 -17.640 6.706   8.088  -2.692 1.663  H321 A1APF 83 
A1APF H322 H37 H 0 0 N N N N N N -49.339 -17.698 5.781   7.390  -2.744 0.026  H322 A1APF 84 
A1APF H332 H38 H 0 0 N N N N N N -48.575 -18.613 7.879   9.205  -4.416 -0.663 H332 A1APF 85 
A1APF H331 H39 H 0 0 N N N N N N -49.849 -18.083 9.029   9.628  -4.335 1.064  H331 A1APF 86 
A1APF H341 H40 H 0 0 N N N N N N -47.681 -16.470 9.749   11.663 -3.628 -1.175 H341 A1APF 87 
A1APF H352 H41 H 0 0 N N N N N N -47.344 -16.480 6.637   8.847  -2.372 -1.905 H352 A1APF 88 
A1APF H351 H42 H 0 0 N N N N N N -47.476 -15.519 8.149   10.578 -2.054 -1.639 H351 A1APF 89 
A1APF H361 H43 H 0 0 N N N N N N -48.995 -13.940 7.063   10.030 0.088  -0.538 H361 A1APF 90 
A1APF H362 H44 H 0 0 N N N N N N -47.496 -14.099 6.086   9.333  0.036  -2.175 H362 A1APF 91 
A1APF H41  H45 H 0 1 N N N N N N -37.707 -12.543 -3.946  -5.705 1.071  0.413  H41  A1APF 92 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1APF N   C    SING N N 1  
A1APF N   C1   SING Y N 2  
A1APF N   N1   SING Y N 3  
A1APF O   C9   DOUB N N 4  
A1APF C1  C2   DOUB Y N 5  
A1APF C10 C11  SING N N 6  
A1APF C10 C14  SING N N 7  
A1APF C10 N4   SING N N 8  
A1APF C11 C12  SING N N 9  
A1APF C12 C13  SING N N 10 
A1APF C13 C14  SING N N 11 
A1APF C14 O1   SING N N 12 
A1APF C15 C16  SING N N 13 
A1APF C15 O1   SING N N 14 
A1APF C16 C17  DOUB Y N 15 
A1APF C16 C21  SING Y N 16 
A1APF C17 C18  SING Y N 17 
A1APF C18 C19  DOUB Y N 18 
A1APF C19 C20  SING Y N 19 
A1APF C19 C22  SING N N 20 
A1APF C2  C3   SING Y N 21 
A1APF C2  C4   SING N N 22 
A1APF C20 C21  DOUB Y N 23 
A1APF C22 C23  DOUB Y N 24 
A1APF C22 C27  SING Y N 25 
A1APF C23 C24  SING Y N 26 
A1APF C24 C25  DOUB Y N 27 
A1APF C25 C26  SING Y N 28 
A1APF C25 C28  SING N N 29 
A1APF C26 C27  DOUB Y N 30 
A1APF C28 C29  SING N N 31 
A1APF C28 C30  SING N N 32 
A1APF C28 N5   SING N N 33 
A1APF C3  N1   DOUB Y N 34 
A1APF C31 C32  SING N N 35 
A1APF C31 N5   SING N N 36 
A1APF C32 N6   SING N N 37 
A1APF C33 C34  SING N N 38 
A1APF C33 N6   SING N N 39 
A1APF C34 O2   DOUB N N 40 
A1APF C35 C36  SING N N 41 
A1APF C35 N6   SING N N 42 
A1APF C36 N5   SING N N 43 
A1APF C4  C5   DOUB Y N 44 
A1APF C4  C8   SING Y N 45 
A1APF C5  N2   SING Y N 46 
A1APF C6  C7   SING Y N 47 
A1APF C6  N2   DOUB Y N 48 
A1APF C6  N3   SING N N 49 
A1APF C7  C8   DOUB Y N 50 
A1APF C7  C9   SING N N 51 
A1APF C9  N4   SING N N 52 
A1APF N3  H33  SING N N 53 
A1APF N3  H32  SING N N 54 
A1APF C5  H51  SING N N 55 
A1APF C8  H81  SING N N 56 
A1APF C10 H101 SING N N 57 
A1APF C13 H131 SING N N 58 
A1APF C13 H132 SING N N 59 
A1APF C15 H151 SING N N 60 
A1APF C15 H152 SING N N 61 
A1APF C17 H171 SING N N 62 
A1APF C20 H201 SING N N 63 
A1APF C21 H211 SING N N 64 
A1APF C24 H241 SING N N 65 
A1APF C26 H261 SING N N 66 
A1APF C   HC3  SING N N 67 
A1APF C   HC1  SING N N 68 
A1APF C   HC2  SING N N 69 
A1APF C1  H11  SING N N 70 
A1APF C11 H111 SING N N 71 
A1APF C11 H112 SING N N 72 
A1APF C12 H121 SING N N 73 
A1APF C12 H122 SING N N 74 
A1APF C14 H141 SING N N 75 
A1APF C18 H181 SING N N 76 
A1APF C23 H231 SING N N 77 
A1APF C27 H271 SING N N 78 
A1APF C29 H292 SING N N 79 
A1APF C29 H293 SING N N 80 
A1APF C29 H291 SING N N 81 
A1APF C3  H31  SING N N 82 
A1APF C30 H302 SING N N 83 
A1APF C30 H301 SING N N 84 
A1APF C30 H303 SING N N 85 
A1APF C31 H312 SING N N 86 
A1APF C31 H311 SING N N 87 
A1APF C32 H321 SING N N 88 
A1APF C32 H322 SING N N 89 
A1APF C33 H332 SING N N 90 
A1APF C33 H331 SING N N 91 
A1APF C34 H341 SING N N 92 
A1APF C35 H352 SING N N 93 
A1APF C35 H351 SING N N 94 
A1APF C36 H361 SING N N 95 
A1APF C36 H362 SING N N 96 
A1APF N4  H41  SING N N 97 
# 
loop_
_pdbx_chem_comp_descriptor.comp_id 
_pdbx_chem_comp_descriptor.type 
_pdbx_chem_comp_descriptor.program 
_pdbx_chem_comp_descriptor.program_version 
_pdbx_chem_comp_descriptor.descriptor 
A1APF SMILES           ACDLabs              12.01 "Cn1cc(cn1)c1cnc(N)c(c1)C(=O)NC1CCCC1OCc1ccc(cc1)c1ccc(cc1)C(C)(C)N1CCN(CC=O)CC1"                                                                                                                                                                       
A1APF InChI            InChI                1.06  "InChI=1S/C37H45N7O3/c1-37(2,44-17-15-43(16-18-44)19-20-45)31-13-11-28(12-14-31)27-9-7-26(8-10-27)25-47-34-6-4-5-33(34)41-36(46)32-21-29(22-39-35(32)38)30-23-40-42(3)24-30/h7-14,20-24,33-34H,4-6,15-19,25H2,1-3H3,(H2,38,39)(H,41,46)/t33-,34+/m1/s1" 
A1APF InChIKey         InChI                1.06  YAMLXCAIPJCCJF-NOCHOARKSA-N                                                                                                                                                                                                                             
A1APF SMILES_CANONICAL CACTVS               3.385 "Cn1cc(cn1)c2cnc(N)c(c2)C(=O)N[C@H]3CCC[C@@H]3OCc4ccc(cc4)c5ccc(cc5)C(C)(C)N6CCN(CC6)CC=O"                                                                                                                                                              
A1APF SMILES           CACTVS               3.385 "Cn1cc(cn1)c2cnc(N)c(c2)C(=O)N[CH]3CCC[CH]3OCc4ccc(cc4)c5ccc(cc5)C(C)(C)N6CCN(CC6)CC=O"                                                                                                                                                                 
A1APF SMILES_CANONICAL "OpenEye OEToolkits" 2.0.7 "CC(C)(c1ccc(cc1)c2ccc(cc2)CO[C@H]3CCC[C@@H]3NC(=O)c4cc(cnc4N)c5cnn(c5)C)N6CCN(CC6)CC=O"                                                                                                                                                                
A1APF SMILES           "OpenEye OEToolkits" 2.0.7 "CC(C)(c1ccc(cc1)c2ccc(cc2)COC3CCCC3NC(=O)c4cc(cnc4N)c5cnn(c5)C)N6CCN(CC6)CC=O"                                                                                                                                                                         
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
A1APF "SYSTEMATIC NAME" ACDLabs              12.01 "(5P)-2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-{(1R,2S)-2-[(4'-{2-[4-(2-oxoethyl)piperazin-1-yl]propan-2-yl}[1,1'-biphenyl]-4-yl)methoxy]cyclopentyl}pyridine-3-carboxamide"       
A1APF "SYSTEMATIC NAME" "OpenEye OEToolkits" 2.0.7 "2-azanyl-5-(1-methylpyrazol-4-yl)-~{N}-[(1~{S},2~{S})-2-[[4-[4-[2-[4-(2-oxidanylideneethyl)piperazin-1-yl]propan-2-yl]phenyl]phenyl]methoxy]cyclopentyl]pyridine-3-carboxamide" 
# 
loop_
_pdbx_chem_comp_audit.comp_id 
_pdbx_chem_comp_audit.action_type 
_pdbx_chem_comp_audit.date 
_pdbx_chem_comp_audit.processing_site 
A1APF "Create component" 2024-04-22 RCSB 
A1APF "Initial release"  2024-10-09 RCSB 
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