Universal Protein Resource (UniProt)
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The Universal Protein Resource (UniProt), a collaboration between the European
Bioinformatics Institute (EBI), the SIB Swiss Institute of Bioinformatics, and
the Protein Information Resource (PIR), is comprised of three databases, each
optimized for different uses. The UniProt Knowledgebase (UniProtKB) is the
central access point for extensively curated protein information, including
function, classification and cross-references. The UniProt Reference Clusters
(UniRef) combine closely related sequences into a single record to speed up
sequence similarity searches. The UniProt Archive (UniParc) is a comprehensive
repository of all protein sequences, consisting only of unique identifiers and
sequences.

The UniProt Knowledgebase (UniProtKB) has been created from Swiss-Prot, TrEMBL
and PIR-PSD. It consists of two parts, one containing fully manually annotated
records and another one with computationally analysed records awaiting full
manual annotation. The two sections will be referred to as the Swiss-Prot
section of the UniProt Knowledgebase (UniProtKB/Swiss-Prot) and TrEMBL section
of the UniProt Knowledgebase (UniProtKB/TrEMBL), respectively. PIR-PSD release
80.0 of 31-Dec-2004 has been fully integrated into these sections. This was the
last release of PIR-PSD.

This directory contains the following subdirectories:

1) Directory /knowledgebase

subdirectory /complete:
This directory contains the eight-weekly updates of the UniProt Knowledgebase,
consisting of UniProtKB/Swiss-Prot (fully annotated curated entries) and
UniProtKB/TrEMBL (computer-generated entries enriched with automated
classification and annotation). Both, UniProtKB/Swiss-Prot and UniProtKB/TrEMBL,
are available separately in flat file, XML and FASTA format.

subdirectory /complete/docs:
This directory contains various UniProt documents.

subdirectory /embeddings:
This directory contains raw embeddings for UniProtKB/Swiss-Prot and some 
reference proteomes of model organisms.

subdirectory /genome_annotation_tracks:
This directory contains the genome annotation tracks files which are updated in
conjunction with UniProtKB.

subdirectory /idmapping:
This directory contains the idmapping data files which are updated in
conjunction with UniProtKB.

subdirectory /pan_proteomes:
This directory contains the pan proteomes data files which are updated in
conjunction with UniProtKB.

subdirectory /proteomics_mapping:
This directory contains the proteomics mapping files which are updated in
conjunction with UniProtKB.

subdirectory /reference_proteomes:
This directory contains the reference proteomes data files which are updated in
conjunction with UniProtKB.

subdirectory /taxonomic_divisions:
This directory contains the same data as provided in the /complete subdirectory,
split into taxonomic divisions.

subdirectory /variants:
This directory contains the variants data files which are updated in conjunction
with UniProtKB.

2) Directory /rdf

This directory contains UniProt data sets in RDF format.

3) Directory /uniparc

This directory contains the eight-weekly update of UniParc, the UniProt Archive
of sequences from UniProtKB and many other databases.

4) Directory /uniref

This directory contains the eight-weekly updates of the UniProt Reference
Clusters (UniRef). There is a subdirectory for each of the three UniRef
databases (which are based on different sequence identity cut-offs): uniref100
(100%), uniref90 (90%) and uniref50 (50%).


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  LICENSE
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We have chosen to apply the Creative Commons Attribution 4.0 International 
(CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) to all 
copyrightable parts of our databases.

(c) 2002-2024 UniProt Consortium

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  DISCLAIMER
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We make no warranties regarding the correctness of the data, and disclaim
liability for damages resulting from its use. We cannot provide unrestricted
permission regarding the use of the data, as some data may be covered by patents
or other rights.

Any medical or genetic information is provided for research, educational and
informational purposes only. It is not in any way intended to be used as a
substitute for professional medical advice, diagnosis, treatment or care.